WO2001072289A3 - Medicament for the stimulation of leucopoiesis and treatment of tumour and protozoan diseases acarinosis and arthropod-borne diseases and a method for production thereof - Google Patents

Medicament for the stimulation of leucopoiesis and treatment of tumour and protozoan diseases acarinosis and arthropod-borne diseases and a method for production thereof

Info

Publication number
WO2001072289A3
WO2001072289A3 PCT/EP2001/003609 EP0103609W WO0172289A3 WO 2001072289 A3 WO2001072289 A3 WO 2001072289A3 EP 0103609 W EP0103609 W EP 0103609W WO 0172289 A3 WO0172289 A3 WO 0172289A3
Authority
WO
WIPO (PCT)
Prior art keywords
mol
diseases
leucopoiesis
acarinosis
tumour
Prior art date
Application number
PCT/EP2001/003609
Other languages
German (de)
French (fr)
Other versions
WO2001072289A2 (en
Inventor
Hansjoerg Eibl
Original Assignee
Max Planck Gesellschaft
Hansjoerg Eibl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft, Hansjoerg Eibl filed Critical Max Planck Gesellschaft
Priority to EP01938070A priority Critical patent/EP1267943A2/en
Priority to MXPA02009434A priority patent/MXPA02009434A/en
Priority to AU2001263828A priority patent/AU2001263828A1/en
Priority to US10/240,199 priority patent/US20030199476A1/en
Priority to JP2001570250A priority patent/JP2003528134A/en
Priority to BR0109799-7A priority patent/BR0109799A/en
Priority to CA002404322A priority patent/CA2404322A1/en
Priority to IL15192601A priority patent/IL151926A0/en
Publication of WO2001072289A2 publication Critical patent/WO2001072289A2/en
Publication of WO2001072289A3 publication Critical patent/WO2001072289A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The invention relates to pharmaceutical formulations for the stimulation of leucopoiesis and treatment of tumour and protozoan diseases, acarinosis and diseases caused by arthropods, characterised in that they contain an effective mixture of a) at least one phospholipid compound of formula (I), where R1 = a 16 to 24 C hydrocarbon residue, R?2, R3 and R4¿ = independently, H, C¿1?-C5 alkyl, C3-C6 cycloalkyl or C1-C5 hydroxyalkyl, where two of R?2, R3 and R4¿ together form a C¿2?-C5 alkylene group, optionally substituted with an -O-, -S- or NR?5¿ group, where R5 = H, C¿1?-C5 alkyl, C3-C6 cycloalkyl or C1-C5 hydroxyalkyl and n = a whole number from 2 to 6 as an active ingredient at from 30 to 60 mol %, b) cholesterol, and/or cholesterol derivatives at from 25 to 65 mol %, c) a phosphatidylmono- or phosphatidyloligo-glycerine, containing at least one oleyl group at from 5 to 15 mol %, where a), b) and c) together make 100 mol % and d) a water-miscible physiologically acceptable alcohol with 2 to 4 C atoms, which optionally contains water and optionally conventional pharmaceutical adjuncts, whereby the above components are in the form of a complex dispersed in water. The invention further relates to a method for the production thereof.
PCT/EP2001/003609 2000-03-30 2001-03-29 Medicament for the stimulation of leucopoiesis and treatment of tumour and protozoan diseases acarinosis and arthropod-borne diseases and a method for production thereof WO2001072289A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
EP01938070A EP1267943A2 (en) 2000-03-30 2001-03-29 Medicament for the stimulation of leucopoiesis and treatment of tumour and protozoan diseases acarinosis and arthropod-borne diseases and a method for production thereof
MXPA02009434A MXPA02009434A (en) 2000-03-30 2001-03-29 Medicament for the stimulation of leucopoiesis and treatment of tumour and protozoan diseases acarinosis and arthropod borne diseases and a method for production thereof.
AU2001263828A AU2001263828A1 (en) 2000-03-30 2001-03-29 Medicament for the stimulation of leucopoiesis and treatment of tumour and protozoan diseases acarinosis and arthropod-borne diseases and a method for production thereof
US10/240,199 US20030199476A1 (en) 2000-03-30 2001-03-29 Medicament for the stimulation of leucopoiesis and treatment of tumour and protozoan diseases acarinosis and arthropod-borne diseases and a method for production thereof
JP2001570250A JP2003528134A (en) 2000-03-30 2001-03-29 Pharmaceutical composition for stimulating leukocyte production and for treating tumors and protozoosis and for treating mite and arthropod-borne infections, and process for producing the same
BR0109799-7A BR0109799A (en) 2000-03-30 2001-03-29 Drug to stimulate leukopoesis for treatment of tumor and protozoal diseases, acarinose, arthropodiasis and process for its production
CA002404322A CA2404322A1 (en) 2000-03-30 2001-03-29 Medicament for the stimulation of leucopoiesis and treatment of tumour and protozoan diseases acarinosis and arthropod-borne diseases and a method for production thereof
IL15192601A IL151926A0 (en) 2000-03-30 2001-03-29 Drug for stimulating leucopoiesis and for treating tumour diseases, protozoal diseases, acariasis and arthropodiasis, and process for producing it

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10015814.5 2000-03-30
DE10015814A DE10015814A1 (en) 2000-03-30 2000-03-30 Medicines to stimulate leukopoiesis, treat tumors and protozoan diseases and process for its manufacture

Publications (2)

Publication Number Publication Date
WO2001072289A2 WO2001072289A2 (en) 2001-10-04
WO2001072289A3 true WO2001072289A3 (en) 2002-04-18

Family

ID=7636966

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/003609 WO2001072289A2 (en) 2000-03-30 2001-03-29 Medicament for the stimulation of leucopoiesis and treatment of tumour and protozoan diseases acarinosis and arthropod-borne diseases and a method for production thereof

Country Status (11)

Country Link
US (1) US20030199476A1 (en)
EP (1) EP1267943A2 (en)
JP (1) JP2003528134A (en)
CN (1) CN1426311A (en)
AU (1) AU2001263828A1 (en)
BR (1) BR0109799A (en)
CA (1) CA2404322A1 (en)
DE (1) DE10015814A1 (en)
IL (1) IL151926A0 (en)
MX (1) MXPA02009434A (en)
WO (1) WO2001072289A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10148067A1 (en) * 2001-09-28 2003-04-17 Max Planck Gesellschaft Heat sterilizable alkyl phosphocholine liposomes
DE10148066A1 (en) * 2001-09-28 2003-04-24 Max Planck Gesellschaft Liposomes containing (ether) lysolecithins
ES2184650B1 (en) * 2001-10-10 2004-09-16 Farmaleis, S.L. USE OF CHOLESTEROL AND PHOSPHOLIPIDS IN MEDICINES FOR THE TREATMENT OF LEISHMANIASIS IN LOS CANIDOS.
CA2584537C (en) * 2004-10-19 2013-09-24 Hansjorg Eibl Formulations containing alkylphosphocholines using novel negative charge carriers
EP1745788A1 (en) 2005-07-22 2007-01-24 KTB Tumorforschungsgesellschaft mbH Acyglycerophospholipids for treating cancer and cachexia
EA029363B1 (en) * 2012-08-13 2018-03-30 Адифарм Еад Pharmaceutical formulations containing 3-(4-cinnamyl-1-piperazinyl) amino derivatives of 3-formyl rifamycin sv and 3-formyl rifamycin s and a process of their preparation
EP3895709A1 (en) 2020-04-17 2021-10-20 Andreas Hettich GmbH & Co. KG Phospholipids and phospholipid metabolites for the treatment of viral and bacterial lung inflammation and sepsis

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0319136A1 (en) * 1987-10-28 1989-06-07 K & V LICENCING OY Novel liposomes and a process for their preparation
DE19835611A1 (en) * 1998-08-06 2000-02-10 Max Planck Gesellschaft Novel phospholipids with synthetic, unsaturated alkyl and acyl chains

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU201567B (en) * 1988-07-21 1990-11-28 Gyogyszerkutato Intezet Process for production of intravenous medical compositions containing cyclosphorin
DE4111105A1 (en) * 1991-04-05 1992-10-08 Max Planck Gesellschaft NEW ERUCYL, BRASSIDYL AND NERVONYL DERIVATIVES
DE4132344A1 (en) * 1991-09-27 1993-04-01 Max Planck Gesellschaft METHOD FOR PRODUCING A MEDAL FOR ORAL OR TOPICAL ADMINISTRATION IN THE TREATMENT OF LEISHMANIASIS
WO1997030058A1 (en) * 1996-02-16 1997-08-21 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Phosphatidyl oligoglycerols

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0319136A1 (en) * 1987-10-28 1989-06-07 K & V LICENCING OY Novel liposomes and a process for their preparation
DE19835611A1 (en) * 1998-08-06 2000-02-10 Max Planck Gesellschaft Novel phospholipids with synthetic, unsaturated alkyl and acyl chains

Also Published As

Publication number Publication date
CA2404322A1 (en) 2002-09-24
MXPA02009434A (en) 2003-09-22
WO2001072289A2 (en) 2001-10-04
IL151926A0 (en) 2003-04-10
AU2001263828A1 (en) 2001-10-08
DE10015814A1 (en) 2001-10-11
EP1267943A2 (en) 2003-01-02
CN1426311A (en) 2003-06-25
JP2003528134A (en) 2003-09-24
US20030199476A1 (en) 2003-10-23
BR0109799A (en) 2003-01-21

Similar Documents

Publication Publication Date Title
RU2395500C2 (en) 2,4-pyrimidine diamines used in treating neoplastic diseases, inflammatory and immune disorders
WO2001098277A3 (en) Substituted bicyclic derivatives for the treatment of abnormal cell growth
DE69426331D1 (en) MEDICINE FOR NERVOUS DISEASES
AP1822A (en) Substituted pyridinones as modulators of P38 MAP kinase.
WO2007137030A3 (en) Cns active fused bicycloheterocycle substituted azabicyclic alkane derivatives
WO1999064409A3 (en) Benzothiepine-1,1-dioxide derivatives, method for producing them, medicaments containing these compounds and their use
RU94019334A (en) Inhibitors of steroid sulfatase
ES2053508T3 (en) COMPOUNDS OF 3-PIRROLIDINYL-THIO-1-AZABICICLO (3.2.0) HEPT-2-ENO-2-CARBOXILICOS.
WO2003048164A3 (en) Adenosine a2a receptor antagonists
CA2238875A1 (en) Tri-aryl ethane derivatives as pde iv inhibitors
TR200101711T2 (en) Antihistamine spiro compounds.
NO943895D0 (en) Galantamine derivatives, a method of preparation and their use as medicaments
HUT62454A (en) Stable pharmaceutical composition suitable for parenteral administration and process for producing same
WO2001072289A3 (en) Medicament for the stimulation of leucopoiesis and treatment of tumour and protozoan diseases acarinosis and arthropod-borne diseases and a method for production thereof
HK1055741A1 (en) A pyridine-1-oxide derivative, and process for itstransformation into pharmaceutically effective co mpounds
NO965444L (en) Triterpene derivative as well as drug composition comprising this
BG103426A (en) Derivatives of substituted 4-biphenyl-4-hydroxy-oil acids as inhibitors of matrix metalloproteases
EP0645382A4 (en) Coumarin derivative and use thereof.
HUP0001773A2 (en) Substituted tetrahydropyridin derivatives, method of preparation and pharmaceutical compositions containing them
MA27260A1 (en) New 3- (4-oxo-4H-chromen-2-yl) - (1H) -quinoline-4-ones derivatives, process for their preparation and pharmaceutical compositions containing them
RU2005105693A (en) APPLICATION OF ALKYLPHOSPHOCHOLINS AND MEDICINAL PRODUCT FOR TREATMENT OF TUMOR DISEASES
HUP0202647A2 (en) Arylalkanoyl derivatives, processes for their preparation, their use and pharmaceutical compositions containing them
WO2000008006A3 (en) Piperidine and piperazine derivatives, process for their preparation and pharmaceutical compounds containing them
AU629967B2 (en) Improvements in or relating to organic compounds
ATE131480T1 (en) PYRIMIDOINDOLE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 2404322

Country of ref document: CA

Ref document number: IN/PCT/2002/1206/KOL

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 151926

Country of ref document: IL

WWE Wipo information: entry into national phase

Ref document number: PA/a/2002/009434

Country of ref document: MX

ENP Entry into the national phase

Ref document number: 2001 570250

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: P-742/02

Country of ref document: YU

WWE Wipo information: entry into national phase

Ref document number: 2001263828

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2001938070

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 018086314

Country of ref document: CN

WWP Wipo information: published in national office

Ref document number: 2001938070

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWE Wipo information: entry into national phase

Ref document number: 10240199

Country of ref document: US

WWW Wipo information: withdrawn in national office

Ref document number: 2001938070

Country of ref document: EP