WO2001066243A3 - Matrix-reaktor und verfahren zur herstellung von produkten in diesem reaktor - Google Patents

Matrix-reaktor und verfahren zur herstellung von produkten in diesem reaktor Download PDF

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Publication number
WO2001066243A3
WO2001066243A3 PCT/EP2001/002548 EP0102548W WO0166243A3 WO 2001066243 A3 WO2001066243 A3 WO 2001066243A3 EP 0102548 W EP0102548 W EP 0102548W WO 0166243 A3 WO0166243 A3 WO 0166243A3
Authority
WO
WIPO (PCT)
Prior art keywords
matrix
reactor
reaction
compartment
molecular
Prior art date
Application number
PCT/EP2001/002548
Other languages
English (en)
French (fr)
Other versions
WO2001066243A2 (de
Inventor
Bernd Buchberger
Wolfgang Mutter
Albert Roeder
Original Assignee
Roche Diagnostics Gmbh
Bernd Buchberger
Wolfgang Mutter
Albert Roeder
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics Gmbh, Bernd Buchberger, Wolfgang Mutter, Albert Roeder filed Critical Roche Diagnostics Gmbh
Priority to EP01911745A priority Critical patent/EP1263981A2/de
Priority to JP2001564887A priority patent/JP2003525616A/ja
Priority to AU40683/01A priority patent/AU4068301A/en
Priority to US10/221,124 priority patent/US7192767B2/en
Priority to CA002401839A priority patent/CA2401839A1/en
Publication of WO2001066243A2 publication Critical patent/WO2001066243A2/de
Publication of WO2001066243A3 publication Critical patent/WO2001066243A3/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43595—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from coelenteratae, e.g. medusae
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/005—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

Gegenstand der vorliegenden Erfindung ist ein Matrix-Reaktor für Reaktionen, an denen niedermolekulare und hochmolekulare Reaktionsteilnehmer beteiligt sind, wobei der Reaktorraum VR eine Matrix enthält und sowohl Reaktionskompartiment als auch Versorgungskompartiment umfasst, die Matrix aus einem porösen Material besteht, welches niedermolekulare Reaktionsteilnehmer aufnehmen kann, und als Reaktionskompartiment das Ausschlussvolumen VO der Matrix und als Versorgungskompartiment das Matrixvolumen VM zur Verfügung stehen. Der Matrix-Reaktor kann für enzymatische Verfahren verwendet werden, insbesondere für die gekoppelte in vitro Transkription-/Translationsreaktion zur Herstellung von Proteinen.
PCT/EP2001/002548 2000-03-08 2001-03-07 Matrix-reaktor und verfahren zur herstellung von produkten in diesem reaktor WO2001066243A2 (de)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP01911745A EP1263981A2 (de) 2000-03-08 2001-03-07 Matrix-reaktor und verfahren zur herstellung von produkten in diesem reaktor
JP2001564887A JP2003525616A (ja) 2000-03-08 2001-03-07 マトリックス反応器および該反応器内での産物の製造方法
AU40683/01A AU4068301A (en) 2000-03-08 2001-03-07 Matrix reactor and a method for producing products in said reactor
US10/221,124 US7192767B2 (en) 2000-03-08 2001-03-07 Matrix reactor and a method for producing products in said reactor
CA002401839A CA2401839A1 (en) 2000-03-08 2001-03-07 Matrix reactor and a method for producing products in said reactor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10011209A DE10011209A1 (de) 2000-03-08 2000-03-08 Matrix-Reaktor und Verfahren zur Herstellung von Produkten in diesem Reaktor
DE10011209.9 2000-03-08

Publications (2)

Publication Number Publication Date
WO2001066243A2 WO2001066243A2 (de) 2001-09-13
WO2001066243A3 true WO2001066243A3 (de) 2001-12-27

Family

ID=7633922

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/002548 WO2001066243A2 (de) 2000-03-08 2001-03-07 Matrix-reaktor und verfahren zur herstellung von produkten in diesem reaktor

Country Status (9)

Country Link
US (1) US7192767B2 (de)
EP (1) EP1263981A2 (de)
JP (1) JP2003525616A (de)
CN (1) CN1429275A (de)
AR (1) AR027973A1 (de)
AU (1) AU4068301A (de)
CA (1) CA2401839A1 (de)
DE (1) DE10011209A1 (de)
WO (1) WO2001066243A2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ519011A (en) * 2002-09-01 2005-01-28 Univ Waikato Reaction process
US8277650B2 (en) 2009-03-13 2012-10-02 Terrasep, Llc Methods and apparatus for centrifugal liquid chromatography
CN102703433B (zh) * 2012-06-12 2014-10-08 中国水产科学研究院黄海水产研究所 基于多孔材料的核酸等温扩增试剂的保存方法及试剂

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5478730A (en) * 1988-12-21 1995-12-26 Institute Of Protein Research Method of preparing polypeptides in cell-free translation system
EP0695760A1 (de) * 1994-08-05 1996-02-07 F. Hoffmann-La Roche Ag Tumormarker für Lungenkrebs
US5593856A (en) * 1994-05-04 1997-01-14 Cha-yong Choi Method for producing protein in a cell-free system
US5851907A (en) * 1993-12-20 1998-12-22 Mohan; Subburaman Method for removal of binding proteins from ligands
WO2000058493A1 (en) * 1999-03-25 2000-10-05 Roche Diagnostics Gmbh Method for synthesis of polypeptides in cell-free systems

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1618761A1 (ru) 1987-04-29 1991-01-07 Институт Белка Ан Ссср Способ получени пептидов и белков в бесклеточной системе трансл ции
EP0593757B1 (de) 1989-07-31 1997-01-15 Institute Of Protein Research, Russian Academy Of Sciences Verfahren zur herstellung von polypeptiden in einem zellfreien system
US6033868A (en) * 1994-11-14 2000-03-07 Utah State University In Vitro biosynthesis of proteins in native conformation
JP4021529B2 (ja) 1997-10-28 2007-12-12 株式会社タダノ 作業機の制御装置
AU765632B2 (en) * 1999-05-11 2003-09-25 Cellfree Sciences Co., Ltd. Preparation containing cell extract for synthesizing cell-free protein and means for synthesizing cell-free protein

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5478730A (en) * 1988-12-21 1995-12-26 Institute Of Protein Research Method of preparing polypeptides in cell-free translation system
US5851907A (en) * 1993-12-20 1998-12-22 Mohan; Subburaman Method for removal of binding proteins from ligands
US5593856A (en) * 1994-05-04 1997-01-14 Cha-yong Choi Method for producing protein in a cell-free system
EP0695760A1 (de) * 1994-08-05 1996-02-07 F. Hoffmann-La Roche Ag Tumormarker für Lungenkrebs
WO2000058493A1 (en) * 1999-03-25 2000-10-05 Roche Diagnostics Gmbh Method for synthesis of polypeptides in cell-free systems

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BARKER P E: "Chromatographic Reactor Separator", RESEARCH DISCLOSURE, vol. 277, no. 57, 1987, pages 328, XP002175277 *
SPIRIN, A S: "Cell-Free Protein Synthesis Bioreactor", 1992, FRONTIERS IN BIOPROCESSING II; AMERICAN CHEMICAL SOCIETY, TODD, P ET AL. (ED.), WASHINGTON DC, USA, XP001023126 *

Also Published As

Publication number Publication date
EP1263981A2 (de) 2002-12-11
CA2401839A1 (en) 2001-09-13
US20040053405A1 (en) 2004-03-18
WO2001066243A2 (de) 2001-09-13
DE10011209A1 (de) 2001-09-13
JP2003525616A (ja) 2003-09-02
US7192767B2 (en) 2007-03-20
CN1429275A (zh) 2003-07-09
AU4068301A (en) 2001-09-17
AR027973A1 (es) 2003-04-23

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