WO2001034102A1 - Compositions de soin pour les cheveux et le cuir chevelu - Google Patents

Compositions de soin pour les cheveux et le cuir chevelu Download PDF

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Publication number
WO2001034102A1
WO2001034102A1 PCT/JP2000/000923 JP0000923W WO0134102A1 WO 2001034102 A1 WO2001034102 A1 WO 2001034102A1 JP 0000923 W JP0000923 W JP 0000923W WO 0134102 A1 WO0134102 A1 WO 0134102A1
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WIPO (PCT)
Prior art keywords
extract
hair
scalp
composition
scientific name
Prior art date
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PCT/JP2000/000923
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English (en)
Japanese (ja)
Inventor
Yuki Shibata
Yoshiharu Tsuji
Nao Kojima
Ohji Ifuku
Ritsuro Ideta
Tsutomu Soma
Masahiro Ota
Naomi Ohta
Daigo Mizumoto
Masaaki Uemura
Yoshiki Moriya
Original Assignee
Shiseido Company, Ltd.
MORIYA, Tamotsu
MORIYA, Nakako
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Priority claimed from JP31755099A external-priority patent/JP2001131032A/ja
Priority claimed from JP31661199A external-priority patent/JP2001131026A/ja
Application filed by Shiseido Company, Ltd., MORIYA, Tamotsu, MORIYA, Nakako filed Critical Shiseido Company, Ltd.
Priority to KR1020027005929A priority Critical patent/KR20020050261A/ko
Publication of WO2001034102A1 publication Critical patent/WO2001034102A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/006—Antidandruff preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9755—Gymnosperms [Coniferophyta]
    • A61K8/9767—Pinaceae [Pine family], e.g. pine or cedar
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/70—Biological properties of the composition as a whole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782—Enzyme inhibitors; Enzyme antagonists

Definitions

  • the present invention relates to a composition for scalp hair which can be used as an anti-grey hair cosmetic or the like.
  • Tyrosinase is a black pigment that plays a major role in absorbing excess light
  • tyrosinase is deeply involved in scalp darkening of the hair (blackening), and it has been shown that a decrease in tyrosinase activity in the scalp is one of the causes of hair graying. .
  • Japanese Patent Application Laid-Open No. H07-112129 describes the invention described in Japanese Patent Application Laid-Open Nos. 7-831 and 7-316020 and can exert both the effect of growing hair and the effect of preventing gray hair.
  • the inventions described in JP-A-78-718 and JP-A-7-126129 are proposed. Due to the excellent tyrosinase activity promoting effect, blackening of gray hair can also be expected according to the invention capable of promoting the activity of tyrosinase.
  • the removal of gray hair makes it less noticeable, and only an effect comparable to that expected for blackening of the white hair is obtained.
  • it is not necessarily effective for improving gray hair It was a bad thing.
  • An object of the present invention is to provide a scalp / head hair composition which can exhibit an anti-grey-hair effect beyond the already proposed invention by combining a tyrosinase activity promoter as a key component and various elements.
  • the composition for scalp and hair has an anti-greyness effect, a hair loss preventing effect and a hair nourishing effect on the scalp, and also a dandruff and power yumi prevention effect on the scalp and a softening effect, thereby improving the scalp and hair.
  • the goal was to be able to comprehensively improve the condition. Disclosure of the invention
  • the present inventor has set forth: (a) one or more tyrosinase activity promoters as essential components; (b) one or more of a penetration enhancer and Z or a blood flow enhancer; c) one or more hair follicle activators, or (d) one or more of five hair reductase inhibitors, in combination with each other or alone, containing the composition for scalp and hair. It has been found that the above problem can be solved by using the component.
  • a composition for scalp hair of the present invention is also referred to as the present composition.
  • a scalp hair composition is a composition capable of improving the condition of the scalp or hair in some way by externally applying the composition to the scalp or hair.
  • the improvement of the scalp and hair's proneness is, as described above, the effect of preventing scalp hair loss and hair growth, as well as the effect of preventing scalp dandruff and power blemishes and softening effect. It also means suppressing gray hair.
  • An anti-grey-hair cosmetic having a main effect of inhibiting gray hair is one of the most suitably envisaged product embodiments in the present composition.
  • a plant extract that may be contained in the present composition can be obtained from a desired plant material by an ordinary solvent extraction method.
  • a desired plant extract can be obtained by subjecting the plant material to freshness or, if necessary, drying and then subjecting it to solvent extraction as it is or after grinding.
  • the solvent used can be selected from those generally used when extracting plant components from plants, and is not particularly limited.
  • n Lower alcohols such as butyl alcohol
  • polyhydric alcohols such as propylene glycol and 1,3-butylene glycol
  • hydrates of these alcohols and hydrocarbon solvents such as n-hexane and toluene.
  • a lower alcohol such as methanol ethanol as an extraction solvent.
  • the extraction solvent is once distilled off and dried if necessary. It is also possible to mix.
  • the tyrosinase activity promoter is an essential component in all aspects of the present composition.
  • the tyrosinase activity promoter that can be included in the present composition is a component that has an effect of promoting tyrosinase activity and is recognized as safe enough to be incorporated into an external composition. There is no particular limitation.
  • Sansho (scientific name: Zanthoxylum piperi tumCL.) DC).
  • Power Yura ⁇ (alias: no ⁇ 0 Lameria-Laeviga)
  • Kayu rapet ⁇ Scientific name: Parameria laev igata): Guaco misto (scientific name) : Mykania Glomerata)
  • Pinguia Pinguia (Pinguica ⁇ Scientific name: Arctostaphylos Pugens) ⁇ Aritaso ⁇ (Epazota ⁇ Scientific name: Che Lord odium Arabrosioides), Sahote (Zapote, Scientific name: Poterium Zapote) or Axcopa que Extracts of such plants can be used as a tyrosinase activity promoter as a component of the present composition.
  • the salamander extract is an extract from salamander (Zanthoxylu m piperi tuma.) DC) belonging to the genus Citrus genus Citrus, and the fruit (peel), flowers, leaves, and trees of this plant Skin or the like can be used as a raw material for this extract.
  • salamander Zanthoxylu m piperi tuma.
  • the fruit peel
  • Sansho extract is also commercially available.
  • Harvest's Sansho extract Korean Kogyo
  • Huarco Rex Sansha Huarco Rex Sansha
  • Sansho II extract Maruzen Pharmaceutical
  • the power yurabe extract is an extract from a power plant of the Indonesian family belonging to the genus Parameria belonging to the genus Paramecia, which is an extract from the power plant Yurabe (also known as: Parameria 'Raebiga, Kayu rapet, scientific name: Parameria laevi gata). It is possible to use leaves, stems, flowers, bark, seeds or fruits of this plant, or even whole plants as raw materials.
  • Guacomist extract is an extract from Guaco mist (Guanomist, scientific name: Mykania Glomerata), a Brazilian medicinal plant belonging to the genus Asteraceae, which belongs to the genus Asteraceae.
  • the Pingui power extract is an extract from the medicinal plant Pinguica (Pinguica, scientific name: Arctostaphylos Pugens) belonging to the genus Urushi, belonging to the family Ledgeaceae.
  • the leaves, stems, flowers, bark, seeds or fruits of this plant In addition, whole plants can be used as raw materials.
  • the extract of Aritaso ⁇ ⁇ ⁇ ⁇ ⁇ is an extract from the medicinal plant belonging to the genus Akaza, belonging to the genus Akaza (Epazota, scientific name: Chenopodi um Ambrosi oi des), and its leaves, stems, flowers, bark, seeds Alternatively, fruits, or even whole plants, can be used as raw materials.
  • Zapote extract is an extract from the medicinal plant belonging to the genus Poterium, Zapote (Za P0te, scientific name: Poterium Zapote).
  • the leaves, stems, flowers, bark, seeds or fruits of this plant, and even plants Whole grass can be used as a raw material.
  • Agguscopaque extract is an extract from Axcopaque (Gautheria Acuminata), a medicinal medicinal plant belonging to the genus Singulariaceae, which belongs to the genus Lingidae.
  • the leaves, stems, flowers, bark, seeds or seeds of this plant are Fruits and even whole plants can be used as raw materials.
  • the amount of the tyrosinase activity promoter as described above in the present composition should be appropriately selected according to the dosage form and product form of the present composition, and is not particularly limited. However, it is preferably 0.001 to 10.0% by weight, and particularly preferably 0.0005 to 5.0% by weight, based on the whole composition. If the amount of the tyrosinase activity promoter is less than 0.0001% by weight based on the whole composition, the desired effect of preventing gray hair is not sufficiently exhibited, and if it exceeds 10.0% by weight, Formulation problems may occur.
  • the content of the plant extract (not limited to the tyrosinase activity promoter) in the present composition is expressed in terms of% by weight as a dried product or a liquid extract after removing the extraction solvent, unless otherwise specified.
  • the penetration enhancer that can be included in the composition promotes penetration of other essential components of the composition, such as tyrosinase activity enhancer, into the skin, and as long as there is no safety problem as a component of the external preparation
  • the penetration enhancer can be used alone in the present composition, or can be used in combination of two or more.
  • Such a penetration enhancer include, for example, aminoxide, sodium dodecyl sulfate, and hydrogenated castor oil ethylene oxide (40 mol) adduct.
  • aminoxide is exemplified. It is preferred to select and incorporate into the composition.
  • Aminoxide is not particularly limited, but may be, for example, a compound represented by the general formula (II)
  • R 1 R 2 R 3 NO (II) (wherein R ⁇ R 2 and R 3 may be the same or different, and represent, for example, a linear or branched alkyl group having 1 to 25 carbon atoms. . ]
  • dimethylamine oxide represented by the following formula (I) be selected and contained in the present composition. . C3 ⁇ 4 (CH 2 ) CH 3
  • dimethylamoxide (I) dimethylamoxide (hereinafter abbreviated as dimethylamoxide (I)) represented by the above formula (I)
  • dimethylamoxide (I) represented by the above formula (I)
  • the dimethylamine oxide (I) thus produced can be usually contained in the present composition through a purification step by a known purification method such as recrystallization, etc.
  • the amount to be blended should be appropriately selected according to the specific dosage form and form of the present composition, and is not particularly limited. It is preferably 20.0% by weight, and particularly preferably 0.05 to 5.0% by weight. If the blending amount of the penetration enhancer is less than 0.001% by weight based on the whole composition, it is difficult to exert a sufficient penetration promoting effect of the tyrosinase activity enhancer and the like, and the amount is 20.0% by weight. Over the formulation Problems and skin irritation may occur.
  • the blood flow enhancer that can be contained in the present composition is not particularly limited, as long as it is applied to the skin, blood flow is promoted, and there is no safety problem as a component of the external preparation. The mechanism of action should not be questioned.
  • the blood flow enhancer can be used alone in the composition, but can also be used in combination of two or more.
  • the blood flow promoting agent examples include nicotinic acid and its derivatives (in the present application, these are defined as nicotinic acids), minoxidil and its derivatives and analogs thereof (in the present application, these are referred to as nicotinic acid and derivatives thereof).
  • Minoxidil sempuri extract, cepharanthin, vitamin E and its derivatives (in the present application, these are defined as vitamin Es), 7-oryzanol, alkoxycarbonyl pyridine n-oxide, chloride chloride, acetylcholine And derivatives thereof (in the present application, these are defined as acetylcholines) and the like, which are blended as a blood flow promoter in general hair cosmetics such as hair restorer.
  • nicotinic acid derivative examples include benzyl nicotinate, tocopherol nicotinate, 5-butoxyshethyl nicotinate, amide nicotinate and the like.
  • nicotinic acids are currently commercially available and can be produced by a known production method.
  • Minoxidil has a peripheral vasodilatory effect and has been used for the treatment of intractable hypertension, but since its hairy side effect was recognized as a side effect, it has been used as a topical topical agent.
  • Yes U.S. Pat. Nos. 4,139,619 and 4,596,812
  • minoxidil derivative examples include a salt of minoxidil, and examples of the analog include an conjugate of minoxidil. These minoxidils are currently commercially available and can be produced by a known production method.
  • the assembly extract is an extract containing the bitter glycoside of the gentian family (Swertia japoni ca akino) (the main component is swertiamarin.
  • this extract is also included in the extract. It is a blood flow enhancer that is said to promote blood flow by expanding the capillaries of the skin.
  • Sempuli extract is currently commercially available [Havex Sempuli Extract (Koei Kogyo), Sempuli Extract A (Alps Pharmaceutical), Sempuli Extract Liquid (Maruzen Pharmaceutical), etc.], and by known methods. Can be obtained by extraction.
  • biminamine E derivative examples include tocopherol acetate and tocopherol nicotinate.
  • Oryzanol is contained in the seed coat of rice (Oryza sat iva L. (Gramineae)), and is mainly composed of a fureric acid ester of triterpene alcohol, and has an effect of promoting blood flow in capillaries. is there.
  • the amount of the blood flow enhancer in the composition is preferably 0.01 to 5.0% by weight, and more preferably 0.01 to 2.0% by weight based on the total amount of the composition. Is particularly preferred. If the amount of the blood flow promoting agent is less than 0.01% by weight based on the total amount of the composition, it is difficult to exhibit a sufficient blood flow promoting effect and realize a synergistic gray hair preventing effect. If the content is more than 5.0% by weight, a problem may occur from the viewpoint of safety, such as skin irritation.
  • the prevention or suppression of the generation of gray hair is superior to the case where the tyrosinase activity promoter is blended alone.
  • the present composition having an effect is provided.
  • the hair follicle activator that can be contained in the present composition exerts a hair nourishing effect (a hair loss suppressing effect, a hair growth promoting effect, an anti-dandruff / power-stain prevention effect, etc.) by activating the hair follicles of human hair.
  • a hair nourishing effect a hair loss suppressing effect, a hair growth promoting effect, an anti-dandruff / power-stain prevention effect, etc.
  • the hair follicle activator can be used alone in the composition, but can be used in combination of two or more.
  • the hair follicle activator specifically, for example, nicotinic acid Ami de, vitamin B e include, Piochin, pantothenic acid, cepharanthine, mononitroguayacol acids, 6-benzyl ⁇ amino purine, diisopropylamine di chloroacetic acid, Hinokichio And pentadecanoic acid monoglyceride.
  • the hair follicle activator overlaps with the blood flow enhancer described above.
  • the agent of the present invention is used as an agent of any concept that can be contained in the present composition.
  • the present composition in such an embodiment is also an invention within the technical scope of the present invention.
  • the content of the hair follicle activator of the present composition is preferably from 0.01 to 5.0% by weight, preferably from 0.01 to 2.0% by weight, based on the total amount of the composition. It is especially preferred. If the amount of the hair follicle activator is less than 0.001% by weight based on the total amount of the composition, the desired effect of preventing hair loss and hair growth, as well as the effect of preventing dandruff and scalp on the scalp, is synergistic. It is also difficult to achieve a typical gray hair prevention effect, and if it exceeds 5.0% by weight, it may be inconvenient in terms of formulation and the scalp tends to cause discomfort.
  • the present composition having a preventive or inhibitory effect of the present invention is provided. Further, the present composition is provided which has a hair-growth effect as well as a gray-hair suppression effect.
  • the 5-hair reductase inhibitor that can be contained in the present composition exerts the effect of preventing hair loss by inhibiting the action of 5-reductase in human hair follicles, and is a safety problem as a component of an external preparation. As long as there is no particular limitation, no particular limitation is imposed on the mechanism of action. Also, 5—reductase inhibitors While it is possible for the composition to be used alone, it may also be used in combination of two or more.
  • 5-reductase inhibitor examples include, for example, assenja extract, Achicolia (scientific name: Taraxacam of ficinales) extract, yervaluiza extract, yichii (Taxus cuspidata) extract, and inchinazu (Coronopus didymus).
  • aurant icus extract scallop (Schizonepeta tenui fol ia) extract, squirrel extract, geranium Siebold et Zuccarini (Geraniaceae) extract, Cuachalalate (scientific name: Juliana ana adtri ngens) extract, Kusanoo (Chel idonium majus subsp.
  • Asiat icum) extract Kumaseba extract (Swartzia polyphyl la) extract , Burdock extract, Korean oil, honey locust (Gledi tsia (Gledi tschia) japonica) extract, Psycho extract, Sanshishi extract, Peony extract, Shazenshi extract, Jang Kang, Scientific name: Stercul ia foetida) extract, Japanese fir (Dichroa febri fuga) extract, Sedro (Cedrela odorata L.) extract, Cedron extract, Senso ⁇ (Rubia c ordifol ia var.
  • Mimj ista) extract Senso extract, Soybean extract, Daio extract, Downtrath (Daun traws, Scientific name: Liteseapdorifera Val) extract, Chanca pidra, Scientific name: Phyllanth Niruri L.) extract, clove extract, nigaki (Picrasma quassioides) extract, areca (Areca catechu L.) extract, Machiko (Matico, scientific name: Piper angusl ifolum) extract, Yakumo somaha extract bicolor Turcz.) extract, koninin extract, Regulo (Reglo, scientific name: Abelmoschus ffloschatus) extract, rosin, ivy extract, Altea (A lt aea off i cinal is L.
  • Roeraen (Cue urbi taceae)) extract, Kikyoyo (Platycodon grandi florum) extract, pine extract, kujin extract, safflower extract, barberry extract, eucalyptus extract, mokku extract, gossip extract, cinnamon extract, hop extract Extract, chrysanthemum extract, senega extract, senki yu extract, katsuko extract, button (Paeonia suffruticosa Andrews (Poeonia montan Sims) (Paeoniaceae)) extract, Maikai power extract, saffron extract , Di O ⁇ extracts, Pepami Ntooiru, Kashuu extract, Japanese angelica root extract, a plant-derived component such as Gurichirure Chin acids;
  • 5 ⁇ -reductase inhibitors such as estrone, estradiol, oxendrone, finasteride and the like can be widely used.
  • Asenyaku (Asenyaku) extract is obtained by extracting water from the leaves and shoots of Uncaria gambir Roxburgh (Rubiaceae) with water, and then extracting it from the dried liquid (Asenyaku) with an ethanol solution or the like. Extract.
  • Atticola is a plant belonging to the family Asteraceae and the genus Dandelion.
  • the first leaf of yew contains al power-loid taxine and flavonoid sciadopi tysin.
  • Butterfly is a young bud or fruit of the Japanese sagebrush (Artemisia capi l laris).
  • a fennel extract is an extract obtained by extracting fennel fruit with water, ethanol and the like.
  • Usenaiaoi is also known as Zeniaoi, and the extract can be obtained by extracting the flowers and or leaves thereof with water, ethanol, or the like.
  • Eiji (fruitful) extract is an extract obtained by extracting water, ethanol, or the like from the fruit of wild rose (Rosa mul tif lora Thungerg) or other closely related plants (Rosaceae).
  • Onji (Enshi) is the root of human finfish (Polygala tenui fol ia), whisker (Polygal a japonica) and the like.
  • Asagotica (summer hay) is the spike after the flower of the turtle (Prunel la vulgaris subsp. Asiatica).
  • Kansuko Thistle is native to tropical America, has a peculiar aroma of whole plants, and is medicated as a private medicine in various places, and its extract is used for sublimation, diuresis, eye drops, and the like.
  • Kanokoso extract is an extract obtained from the roots and rhizomes of Kanokoso (Valeriana fauriei Briquest) and Z or other closely related plants (Valerianaceae), usually by extraction with water.
  • Guarana extract is an extract of Paul linia cupana Kunth seeds.
  • Caldosanto is a plant belonging to the genus Poppyceae and the genus Azamigeshi.
  • the extract of licorice can be produced by extracting the root of licorice (Glycyrrhiza uralensis Fisher, Glycyrrhiza g labra L.) and / or its congener (Leguminosae) with water and Z or ethanol.
  • Catalpa extract can be obtained mainly by solvent extraction of catalpa fruit and or bark.
  • Gay mussel extract is a solvent extract of the whole plant of Schi zonepeta tenuifol ia.
  • Gengosi extract is a solvent extract of morning glory (Pharbi tis nil) seeds.
  • Geno ginger extract is an extract obtained mainly by extracting an aerial part of geno ginger with an ethanol solution or the like.
  • Kusanoo extract is usually a solvent extract of the whole plant.
  • Burdock (burdock) extract is a solvent extract of burdock (Arctium lappa) fruit.
  • Coriander oil is an essential oil obtained from the fruits of Coriander (Coriandrum sativum L.).
  • the honey locust extract is mainly a solvent extract of honey locust fruit and Z or seed.
  • Sanshin extract is a solvent extract of the fruits of gardenia (Gardenia jasminoides var. Grandi flora).
  • Peony extract is an extract obtained by solvent extraction from roots of Paeonia (Paeonia lactif lora Pal las (Paeonia albi flora P; al las var. Trichocarpa Bunge)) or its closely related plant (Paeoniaceae) ⁇ It is.
  • Shazenshi extract is a solvent extract of seeds such as planta asiatica.
  • Daio extract is a solvent extract of roots such as Xining Daihuang (Rheum palmatum), Sichuan Daihuang (Rheum tanguticum), Yunnan Daihuang (Rheum off icinale).
  • the extract of clover is a solvent extract obtained by drying buds of crab (Syzygium aromat icum Merri l l et Perr y (Eugenia caryophyl lata Thungerg) (Myrtaceae)), but using ethanol or the like.
  • Areca extract is a solvent extract of areca fruit and Z or seeds (Acacia: areca).
  • the extract of Yakmo-so (mother grass) is a solvent extract of the whole plant of swordfish (Leonurus sibiri cus).
  • a yamahagi extract is a solvent extract of yamahagi leaves and grape or stem.
  • the kuinin extract is an extract obtained by extracting the seed of the wheat (Coix lacryma-jobi L. var.ma-yuen Stapf (Gramineae)) from the seed coat with an extraction solvent such as water or ethanol. .
  • Rosin is a solid resin obtained by removing the essential oil from the secretion of Pinus plants (eg, Pinus densif lora) and black pine (Pinus thiinbergii).
  • the ivy extract is a solvent for the roots and stems of G. nanking, G. hirsutum, G. arboreum, and G. Herbaceum, for example, G. nanking. It is an extract.
  • Altea extract is derived from roots and leaves or leaves of the piloa mallow (Al thaea off icinal is L. (Malvaceae)), containing water, ethanol, propylene glycol and 1% urea. It is an extract obtained by extraction with an extraction solvent such as an ethanol-containing solution.
  • Youti (Yotei) extract is a solvent extract of the roots of Rumex japonicus Hout t.
  • Aloe extract 1 Aloe ferox Mi ler, or a hybrid of this with Aloe africana Mi ler or Aloe spicata Baker (Li liaceae), and some are Aloe barbadens is Mi ler (Aloe vera) or Extracts obtained by extracting leaves or leaf sap of Kidoe aloe (Aloe arborescens Miller) and also a variety of Kidachiaroe (Li 1 iaceae) with an extraction solvent such as water or ethanol; Aloe barbadens is Mil ler (Aloe vera L.) or Kidachi aloe (Aloe arborescens Mil ler), and the sap obtained from the leaves of the varieties of Kidachi aloe (Li Liaceae) is obtained after removing the aloin. It is an extract obtained by extracting or dissolving the obtained powder with water, ethanol or the like.
  • Wolfberry extract is a solvent extract of the roots, fruits or leaves of wolfberry.
  • the extract of Artemisia princeps Pampanini, Artemisia mongol ia Fischer or Artemisia montana Pampanini is extracted from leaves of Artemisia montana Pampanini (Composi tae). It is.
  • the mansilium extract is a solvent extract of the fruit of Egg (Vitex rotundifolia L. fil.).
  • Mannenwax (Rosemari I) extract is extracted from leaves and / or flowers of Mannenwax with an extraction solvent such as water, ethanol or ethanol containing 1% urea. Extracts obtained by the extraction, or (3) powdered leaves of Mannenwax, (2) essential oil obtained by steam distillation of fresh leaves, stem tips, and flowers of Mannenwax.
  • Kossaiho (bone crushing) extract can be obtained with a solvent extract of rhizomes, such as Hakamauraboshi (Drynaria fortunei), Drynaria sinica, and Ograsedonda (Agraomorpha coronans).
  • Enishida extract is a solvent extract of the technical leaves of Enishida.
  • Gentian extract is a solvent extract of gentian rhizomes and roots (Ryutan). Tanjin extract is a solvent extract of the roots of Salvia mi lti orrhi za.
  • the extract of luffa is: (1) an extract obtained by extracting the aerial part of luffa with an extraction solvent such as water and ethanol; and (2) after removing methanol eluate from the water-extracted extract of the whole plant of luffa.
  • Kikyoyou extract is a solvent extract of the root of Kikyo.
  • the pine extract is an extract obtained by extracting the cone of Pinus sylvestris (Pinaceae) with an extraction solvent such as water, propylene glycol, and ethanol containing 1% urea.
  • the extract of kujin (bitter ginseng) is obtained as a solvent extract of the root of Clara (Sophora angust ifol ia).
  • the safflower extract is obtained by extracting the flower of safflower (Carthamus t inctorius L. (Composi tae)) as it is, or removing most of the yellow pigment, and pressing it into a plate to extract anhydrous ethanol, ethanol solution, etc.
  • An extract obtained by extraction with a solvent and (2) an extract obtained by extracting the whole plant of safflower with an extraction solvent such as an ethanol solution.
  • Barberry extract is a plant belonging to the genus Berberis, such as barberry (B. thunbergi i), hebinoboraz (B. sieboldi i), and Hironohebinoboraz (B. amurensis var. Japonica) It is an extract obtained by extraction with an extraction solvent or the like such as a stem (including berberine).
  • Eucalyptus extract is extracted from the leaves of Eucalyptus (Eucalyptus globulus L) or other closely related plants (Myrtaceae) using water, ethanol, or other extraction solvents, and 2
  • the leaves of Eucalyptus or other closely related plants (Myrtaceae) O essential oil obtained by steam distillation
  • the extract of mokudtsu is a solvent extraction of xylem such as Akebia quinata, A. trifol iata, A. quinata var. Polyphyl la, etc. 0
  • Gossip (cow knee) extract is a solvent extract of roots such as Achyranthes fauriei and A. bid entata.
  • the tea extract is (1) an extract obtained by extracting from the leaves of the tree (Thea sinensis L (Theaceae)) (green tea) with an extraction solvent such as water and ethanol. (2) The defatted seeds of the tree 3 Extracts obtained by extracting with water from water, 3 Fatty oil obtained from the seeds of cypress, Thea sinens is L. (Theaceae).
  • a hop extract is an extract obtained by extracting hop (Humulus lupulus (Moraceae)) female ears with an extraction solvent such as water or ethanol.
  • the chrysanthemum extract is a plant belonging to the genus Chrysanthemum, for example, chrysanthemum (boaleale), oak (C. indicum). martschallii), etc., and is obtained by extraction with an extraction solvent for each part of the plant body.
  • the Senega extract is an extract obtained by extracting a plant belonging to the genus Polygala, for example, roots of Senega (Polygala senega), Hirono senega (Polygala senega var. Latifolia), etc. with an extraction solvent.
  • the extract of Senkiyu is obtained by extracting from the rhizome of (Cnidium officinale akino (Umbel lifer ae)) with an extraction solvent such as water and ethanol, and (2) extracting from the rhizome of Senkiyu with water. It is a liquid obtained by steam distillation from an extract.
  • the katsukon extract is an extract obtained by extracting the pericut root of kudzu (Pueraria lobata Ohwi (Leg inosae)) with an extraction solvent such as anhydrous ethanol.
  • the button extract is an extract obtained by extracting the rhizome of a button (Paeonia suffruticosa Andrews (Poeonia montan Sims) (Paeoniaceae)) with an extraction solvent such as an ethanol solution.
  • a button Paeonia suffruticosa Andrews (Poeonia montan Sims) (Paeoniaceae)
  • an extraction solvent such as an ethanol solution.
  • button extracts include extracts of buttonpi (peony), the root bark of buttons.
  • the Maikai strength extract is an extract obtained by extracting the herb of Maikai (Rosa maikai (R. rugosa var. Plena)) or button rose (Rosa odorata (Andr.) Sweet) with an extraction solvent. .
  • the saffron extract is an extract obtained by extracting the stigma of saffron (Crocus sativus L. (Iridaceae)) with an extraction solvent such as water.
  • the dio extract was prepared from acadia (Rehmaimia glutinosa Libschitz var. PT / JP00 092 ea Makino). Or an extract obtained from roots of other congener plants (Scrophulariaceae) with an extraction solvent such as water or ethanol.
  • Peppermint oil is an essential oil obtained from the stems and leaves of peppermint (Mentha piperita L.) in the Labiatae family.
  • Kashui (Head of Bird) extract is an extract obtained by extracting root nodules of Polygonum multiflorum with an extraction solvent.
  • the extract of Touki is an extract obtained by extracting the root of Touki (Angelica acuti lobaCLigusticum acutilobu m) with an extraction solvent.
  • the content of the 5-hydroxylase inhibitor in the present composition is preferably from 0.001 to 10.0% by weight based on the total amount of the composition, and from 0.01 to 5.0% by weight. Particularly preferred is 0% by weight.
  • the amount of the hair reductase inhibitor is less than 0.01% by weight based on the total amount of the composition, the desired hair loss preventing effect is exhibited, and it is difficult to realize a synergistic white hair preventing effect. If it exceeds 10.0% by weight, it may be inconvenient for the preparation.
  • the present composition having an effect of preventing or inhibiting the development of gray hair is provided.
  • the present composition is provided which has an effect of preventing hair loss as well as an effect of inhibiting gray hair.
  • tyrosinase activity promoters are essential components, and (b) one or two or more penetration enhancers and Z or blood flow promoters, (C) one or more hair follicle activators, or (d) one or more 5-heale reductase inhibitors, in combination with each other or alone, as components of the composition for scalp hair.
  • a scalp hair composition (the present composition) capable of synergistically exhibiting an excellent white hair preventing effect and also exhibiting various hair restoring effects.
  • This composition contains general base ingredients and medicinal ingredients that can be blended with ordinary external compositions (including hair compositions) according to the formulation type and form of the specific composition.
  • Type and It can be blended as long as the desired effect is not impaired in the form.
  • Various drugs, coloring agents, fragrances, and the like can be appropriately selected and blended according to the desired dosage form and form.
  • diluent examples include water, ethanol, isopropyl alcohol, and glycols.
  • examples of the anionic surfactant include alkyl benzene sulfonate, polyoxyalkylene alkyl sulfate, alkyl sulfate ester, olefin sulfonate, alkyl phosphate, and polyoxyalkylene alkyl ether phosphorus. Acid salts, dialkyl sulfosuccinates, fatty acid salts and the like.
  • nonionic surfactants include polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyhydric alcohol fatty acid partial ester, polyoxyethylene polyhydric alcohol fatty acid partial ester, polyglycerin fatty acid ester, and polyoxyethylene cured. Castor oil derivatives, fatty acid diethanolamide and the like.
  • cationic surfactant examples include a tertiary aliphatic amine salt, an alkyltrimethylammonium halide, a dialkyldimethylammonium halide, and the like.
  • amphoteric surfactant examples include amidbetaine type, imidazolinium betaine type, and sulfobetaine type amphoteric surfactants.
  • higher alcohols examples include cetyl alcohol, stearyl alcohol, behenyl alcohol and the like.
  • oil component examples include higher fatty acids, solid paraffin, liquid paraffin, silicone oil, polymeric silicone and its derivatives, squalane, petrolatum, and ester oil.
  • humectant examples include glycerin, propylene glycol, 1,3-butylene glycol, dipropylene glycol, sorbitol and the like. You.
  • thickener examples include methylcellulose, hydroxyshethylcellulose, carrageenan, carboxymethylcellulose, and cationized cellulose.
  • Examples of the solvent include water, ethanol, isopropyl alcohol, benzyl alcohol and the like.
  • Usability improvers include, for example, methylpolysiloxane, methylaminopropylsiloxane and the like.
  • preservative examples include benzoic acid, dehydroacetic acid, para-hydroxybenzoic acid ester (methyl para-oxybenzoate, butyl para-oxybenzoate, etc.), phenoxy ethanol and the like.
  • antioxidant examples include ascorbic acid and BHA.
  • sequestering agent examples include ethylenediaminetetraacetic acid (edetic acid), tripolyphosphate and the like.
  • ultraviolet ray protective agent examples include oxybenzone and butyl methoxy benzoyl methyl.
  • powder component examples include powder resins such as silica, nylon powder, and polyethylene powder.
  • drugs other than vitamins and plant extracts that can be used as essential components in the present invention can be used.
  • anti-inflammatory agents for example, anti-inflammatory agents, antibacterial agents, organic acids, and the like can also be incorporated in the present composition (these various agents can be used in combination as needed). Of course).
  • the dosage form of the composition may be any liquid, emulsion, ointment, or any other form that can be applied to the skin or scalp.
  • lotions, creams, oils, gels, hair tonics, hair liquids It can take the form of treatments, aerosol mousses, aerosol sprays and the like.
  • the composition is applicable in various fields such as pharmaceuticals, quasi-drugs, and cosmetics.
  • the present composition is, as described above, an anti-grey-hair cosmetic having a main effect of inhibiting gray hair is one of the most suitable product embodiments of the present composition.
  • composition is generally used by transdermal administration such as directly applying or spraying on the skin.
  • the amount of the composition to be used should be appropriately determined according to individual differences such as age and degree of gray hair, and the dosage form and form.
  • the blending amount in these examples and the like is% by weight based on the entire system in which the component is blended, unless otherwise specified.
  • a total of 50 Og of Arita soybean was immersed in ethanol at room temperature for 1 week, and ethanol in this extract was distilled off to obtain 9.3 g of Arisa soybean extract.
  • this extract was used as “aritaso ⁇ extract”.
  • a total of 500 g of Axcopaque was immersed in ethanol at room temperature for one week, and ethanol in the extract was distilled off to obtain 9.3 g of an Axcopaque extract.
  • the other plant extracts used in this example specifically, peanut extract, cashew extract, kanzo extract, quayaralarte extract, cilantro extract, janyank extract, toukiki extract, peony extract
  • the extract, the peony extract, the jinxin extract, etc. were produced according to a conventional method for producing the extract.
  • the number of gray hairs after application is less than the number of gray hairs before application
  • the number of gray hairs after application is less than the number of gray hairs before application
  • a tricogram test was also performed to examine the hair growth effect of the test article.
  • the subject was a male, and in each of the comparative examples and examples, there were no subjects.
  • the test period was 4 months, and during the sample application period, the samples were applied to the scalp twice a day, 2 to 4 mL each time.
  • 50 hairs were randomly removed from the crown of each subject, and the roots of the removed hairs were observed under a microscope.
  • the follicle resting rate () was calculated. The percentage of increase / decrease in the rate of rest period before and after sample application was determined based on the following criteria.
  • the change in the number of hair removal due to hair washing before and after use of the sample was used as an index.
  • the subjects were male, and each group consisted of 10 persons in each of the comparative example and the example.
  • the test period was six months, the first two months were the period of no sample application, and the last four months were the sample application period.
  • the hair was washed every other day to collect the hair loss, and one week was counted and the number of the end hairs was counted.
  • the number of hair loss was evaluated using the number of hair loss per hair wash during the sample application period as an index, and the average value in the last week of the first semester and the average value of the last week in the second semester were compared.
  • the results were judged according to the following criteria. The results were evaluated as valid when the percentage of subjects with a score of + or more was 50% or more, and invalid with respect to the others.
  • Soil The number of hair loss decreased by 10 or more, and a slight effect was recognized.
  • dandruff was collected from the head using a suction device, and the amount of protein in the dandruff was measured.
  • each subject was examined for scalp force Yumi, and the degree was evaluated according to the following criteria.
  • test articles corresponding to Examples and Comparative Examples are prepared, and an appropriate one of the above test methods is selected.
  • the present invention was evaluated.
  • prescription examples of each embodiment are listed as g in Examples.
  • Embodiment A An embodiment in which (a) a tyrosinase activity enhancer is combined with (b) a penetration enhancer and / or a blood flow enhancer.
  • Embodiment B Embodiment in which (a) tyrosinase activity promoter and (c) hair follicle activator are combined and combined
  • Embodiment C An embodiment in which (a) a tyrosinase activity promoter is combined with (d) a 5-reductase inhibitor
  • the lotion related to the present composition of embodiment A the lotion having the formulation shown in Table A1 was prepared and subjected to the above-mentioned whitening prevention test.
  • Each lotion was manufactured according to the following manufacturing method.
  • Dimethylamine oxide (I) Dimethylamine oxide (I), nicotinic acid, polyvinylpyrrolidone Z-vinyl acetate copolymer, preservative and fragrance were added to ethanol and uniformly dissolved. To this, the previously dissolved aqueous phase (salmon extract, purified water, silicone derivative and glycerin) was added and dissolved.
  • Comparative Lotion A containing only the ginger extract used as a tyrosinase activity enhancer has the effect of preventing or inhibiting the development of gray hair, but the ginger extract and the permeation enhancement A of the present invention comprising a combination of the lotion A of the present invention, a combination of the extract of Sanshisa, dimethylamine oxide (I), and nicotinic acid, a blood flow promoter, which are combined with the dimethylamine oxide (I) of the present invention.
  • Preparation C of the present invention which is a combination of Shillon B or a combination of salmon extract and nicotinic acid, is superior to Comparative Preparation A in preventing gray hair development. It has also been found to have an inhibitory effect. In addition, it was also found that even if dimethylamine oxide (I) and nicotinic acid alone were used in combination without using the salmon extract, no preventive or inhibitory effect on the generation of gray hair was observed (comparison) Lotion B).
  • the lotions A, B, and C of the present invention in which a permeation enhancer and / or a blood flow enhancer are combined with a salmon extract, which is a tyrosinase activity enhancer, the synergistic prevention or suppression of gray hair development It was clear that the effect was noticeable. This indicates that the desired effect can be obtained only by using a small amount of salamander extract and a penetration enhancer and Z or a blood flow enhancer.
  • Blend amount Weight
  • Blend amount Weight
  • Blend amount Weight
  • phase A (1) to (9) were mixed and dissolved by heating to prepare phase A. Separately, (10) to (15) were mixed and dissolved by heating to prepare phase B. Thereafter, phase B was added to phase A and emulsified with a homomixer to obtain a hair cream.
  • (1) was dispersed in (3) and a part of purified water.
  • the other components were dissolved in the remaining purified water, and this was added to the above-mentioned dispersion while stirring, to obtain Haziel.
  • (1) was dispersed in (2) and a part of purified water.
  • the other components were dissolved in the remaining purified water, and this was added to the above-mentioned dispersion while stirring, to obtain Haziel.
  • (1), (2) and (3) were uniformly emulsified with a homomixer. This was added to (4), (5) to (8), and added to the stirred and dissolved solution to prepare a stock solution (9).
  • the undiluted solution (9) was filled in a can, and after fitting the valve, (10) and (11) were filled to obtain a hair spray.
  • Table B1 (Example) and Table B2 (Comparative Example) show the results of the above-described white hair prevention test for the present composition of Embodiment B, together with the formulation of the test article used.
  • the lotion (Example B1B14) of the present composition in which a hair follicle activator was combined with a tyrosinase activity promoter, showed excellent hair growth. It was clear that the effect and the effect of preventing hair loss were recognized.
  • Table B5 shows the results of the above-mentioned dandruff / force wrinkle prevention effect test on the composition of Embodiment B (Example B1B14 / Comparative Example B1B14). Table B5
  • Blend amount Weight
  • Blend amount Weight
  • Blend amount Weight
  • phase A (1) to (9) were mixed and dissolved by heating to prepare phase A. Separately, (10) to (15) were mixed and dissolved by heating to prepare phase B. Thereafter, phase B was added to phase A and emulsified with a homomixer to obtain a hair cream.
  • Lotions related to the present composition of embodiment C were prepared as shown in Tables C1 and C2 and subjected to the above-mentioned gray hair prevention test.
  • Each lotion was manufactured according to the following manufacturing method.
  • the aqueous extract was prepared by adding the plant extract and succinic acid to the purified water and uniformly dissolving the same.
  • the other raw materials were dissolved in ethanol, and this was added to the aqueous extract and further dissolved. .
  • a lotion of the present composition comprising a combination of a tyrosinase activity promoter and a 5 ⁇ -reductase inhibitor (Examples C1 to (: 12) shows a synergistic effect of white hair development or prevention). This indicates that the use of a small amount of a tyrosinase activity promoter and a 5-hi reductase inhibitor can exert a sufficient gray hair development or prevention effect. It shows.
  • Blend amount Weight
  • Phase A was prepared mixed, heated and dissolved to B phase (10) (15). Thereafter, phase B was added to phase A and emulsified with a homomixer to obtain a hair cream.
  • (1) and (3) were dispersed in a part of purified water.
  • the other components were dissolved in the remaining purified water, and added to the above-mentioned dispersion with stirring to obtain Haziel.
  • (1) and (2) were dispersed in a part of purified water.
  • the other components were dissolved in the remaining purified water, and added to the above-mentioned dispersion with stirring to obtain Haziel.
  • (1), (2) and (3) were uniformly emulsified with a homomixer. This emulsion was added to the solution obtained by adding (5) to (7) to (4) and stirred and dissolved to prepare a stock solution (8).
  • the can was filled with the stock solution (8), and after fitting the valve, (9) and (10) were filled to obtain a hair spray.
  • the present invention provides a scalp hair composition that is extremely useful for preventing and preventing the occurrence of gray hair and that has excellent safety.

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Abstract

L'invention se rapporte à des compositions de soin pour les cheveux et le cuir chevelu qui contiennent: (a) un ou plusieurs promoteurs d'activité de tyrosinase; (b) un ou plusieurs promoteurs de pénétration et/ou agents favorisant la circulation sanguine; (c) un ou plusieurs activateurs des follicules capillaires; et (d) un ou plusieurs inhibiteurs de 5α-réductase. Ces compositions s'avèrent excellentes s'agissant de prévenir le grisonnement des cheveux et également la chute des cheveux, et elles présentent un effet nourrissant sur les cheveux. Ces compositions s'avèrent en outre efficaces pour prévenir les pellicules et les démangeaisons du cuir chevelu et pour adoucir le cuir chevelu, ce qui se traduit par une amélioration totale des conditions du cuir chevelu et des cheveux.
PCT/JP2000/000923 1999-11-08 2000-02-18 Compositions de soin pour les cheveux et le cuir chevelu WO2001034102A1 (fr)

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JP31755099A JP2001131032A (ja) 1999-11-08 1999-11-08 頭皮頭髪用化粧料
JP31661199A JP2001131026A (ja) 1999-11-08 1999-11-08 頭皮頭髪用化粧料
JP11-316611 1999-11-08
JP11-317550 1999-11-08

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KR100436384B1 (ko) * 2001-08-24 2004-06-18 조천호 천연식물 추출물로 이루어진 피부개선 화장료 조성물
CN114292701A (zh) * 2021-12-31 2022-04-08 河南省商业科学研究所有限责任公司 一种牡丹花精油的提取方法

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KR100509910B1 (ko) * 2002-12-12 2005-08-24 (주)케피로스 화장료 조성물
KR100728813B1 (ko) * 2005-08-18 2007-06-19 한불화장품주식회사 고려엉겅퀴 추출물을 주요 활성성분으로 함유하는피부외용제 조성물
KR100747651B1 (ko) 2006-02-01 2007-08-08 조점화 두발 건강유지 및 모발 생장촉진 원료추출물
KR100761660B1 (ko) 2006-03-08 2007-10-04 한국과학기술연구원 모발 성장 촉진 조성물
KR101017129B1 (ko) * 2008-03-04 2011-02-25 청광화학공업(주) 생약 추출물을 함유하는 탈모방지용 두발 화장료 조성물
WO2014189159A1 (fr) * 2013-05-22 2014-11-27 Kim Kwang Soo Composition comportant de l'extrait de pharbitis nil (l.) choisy pour empêcher la perte des cheveux et pour favoriser la croissance des cheveux
KR102429344B1 (ko) * 2016-05-25 2022-08-05 주식회사 엘지생활건강 원지 또는 지골피 추출물을 유효성분으로 포함하는 항비듬용 화장료 조성물.
KR101929153B1 (ko) * 2018-03-12 2018-12-13 김호청 탈모 방지 및 발모 촉진용 조성물 및 이의 제조방법
CN110974738A (zh) * 2019-11-08 2020-04-10 广东雅倩化妆品有限公司 一种具有育发生发功效的组合物及其制备方法和用途
KR102538135B1 (ko) * 2022-08-24 2023-05-31 브링숨 주식회사 천연 복합 추출물을 포함하는 탈모 예방 또는 발모 촉진용 조성물

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JPH10279437A (ja) * 1997-03-31 1998-10-20 Shiseido Co Ltd 頭髪用化粧料
WO1998052516A1 (fr) * 1997-05-19 1998-11-26 Shiseido Company, Ltd. Compositions de soins du cuir chevelu
JP2000072629A (ja) * 1998-08-28 2000-03-07 Shiseido Co Ltd 頭皮頭髪用組成物

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JPH10279437A (ja) * 1997-03-31 1998-10-20 Shiseido Co Ltd 頭髪用化粧料
WO1998052516A1 (fr) * 1997-05-19 1998-11-26 Shiseido Company, Ltd. Compositions de soins du cuir chevelu
JP2000072629A (ja) * 1998-08-28 2000-03-07 Shiseido Co Ltd 頭皮頭髪用組成物

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KR100436384B1 (ko) * 2001-08-24 2004-06-18 조천호 천연식물 추출물로 이루어진 피부개선 화장료 조성물
CN114292701A (zh) * 2021-12-31 2022-04-08 河南省商业科学研究所有限责任公司 一种牡丹花精油的提取方法
CN114292701B (zh) * 2021-12-31 2023-06-06 河南省商业科学研究所有限责任公司 一种牡丹花精油的提取方法

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