WO2001025194A3 - Drug target isogenes: polymorphisms in the 5-hydroxytryptamine (serotonin) receptor 1b gene - Google Patents

Drug target isogenes: polymorphisms in the 5-hydroxytryptamine (serotonin) receptor 1b gene Download PDF

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Publication number
WO2001025194A3
WO2001025194A3 PCT/US2000/027486 US0027486W WO0125194A3 WO 2001025194 A3 WO2001025194 A3 WO 2001025194A3 US 0027486 W US0027486 W US 0027486W WO 0125194 A3 WO0125194 A3 WO 0125194A3
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WO
WIPO (PCT)
Prior art keywords
gene
polymorphisms
hydroxytryptamine
serotonin
receptor
Prior art date
Application number
PCT/US2000/027486
Other languages
French (fr)
Other versions
WO2001025194A2 (en
Inventor
Julie Y Choi
Richard Rex Denton
Krishnan Nandabalan
Joel Claiborne Stephens
Original Assignee
Genaissance Pharmaceuticals
Julie Y Choi
Richard Rex Denton
Krishnan Nandabalan
Joel Claiborne Stephens
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genaissance Pharmaceuticals, Julie Y Choi, Richard Rex Denton, Krishnan Nandabalan, Joel Claiborne Stephens filed Critical Genaissance Pharmaceuticals
Priority to AU79945/00A priority Critical patent/AU7994500A/en
Publication of WO2001025194A2 publication Critical patent/WO2001025194A2/en
Publication of WO2001025194A3 publication Critical patent/WO2001025194A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2535/00—Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
    • C12Q2535/125—Allele specific primer extension
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Abstract

Polynucleotides comprising one or more of 3 novel single nucleotide polymorphisms in the human 5-hydroxytryptamine (serotonin) receptor 1B (HTR1B) gene are described. Compositions and methods for detecting one or more of these polymorphisms are also disclosed. In addition, various genotypes and haplotypes for the HTR1B gene that exist in the population are described.
PCT/US2000/027486 1999-10-07 2000-10-05 Drug target isogenes: polymorphisms in the 5-hydroxytryptamine (serotonin) receptor 1b gene WO2001025194A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU79945/00A AU7994500A (en) 1999-10-07 2000-10-05 Drug target isogenes: polymorphisms in the 5-hydroxytryptamine (serotonin) receptor 1b gene

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15811499P 1999-10-07 1999-10-07
US60/158,114 1999-10-07

Publications (2)

Publication Number Publication Date
WO2001025194A2 WO2001025194A2 (en) 2001-04-12
WO2001025194A3 true WO2001025194A3 (en) 2001-10-18

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/027486 WO2001025194A2 (en) 1999-10-07 2000-10-05 Drug target isogenes: polymorphisms in the 5-hydroxytryptamine (serotonin) receptor 1b gene

Country Status (2)

Country Link
AU (1) AU7994500A (en)
WO (1) WO2001025194A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004537311A (en) * 2001-07-16 2004-12-16 プライス ファンデーション リミテッド Genes and SNPs associated with eating disorders

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ARCH. GEN. PSYCHIATRY, vol. 55, no. 11, 1998, pages 989 - 994 *
CYTOMETRY, vol. 40, no. 2, 2000, pages 102 - 108 *
DATABASE CAPLUS [online] ARMSTRONG ET AL.: "Suspension arrays for high throughput, multiplexed single nucleotide polymorphism genotyping", XP002938285, accession no. STN Database accession no. 2000:406810 *
DATABASE CAPLUS [online] LAPPALAINEN ET AL.: "Linkage of antisocial alcoholism to the serotonin 5-HT 1B receptor gene in 2 populations", XP002938286, accession no. STN Database accession no. 1998:740528 *
MAROTEAUX ET AL.: "Mouse 5HT1B serotonin receptor. Cloning, functional expression, and localezation, and localization in motor control centers", PROC. NATL. ACAD. SCI. USA, vol. 89, no. 7, 1 April 1992 (1992-04-01), pages 3020 - 3024, XP002938288 *
VINCENT ET AL.: "Genetic association analysis of serotonin system genes in bipolar affective disorder", AM. J. PSYCHIATRY, vol. 156, no. 1, January 1999 (1999-01-01), pages 136 - 138, XP002938287 *

Also Published As

Publication number Publication date
WO2001025194A2 (en) 2001-04-12
AU7994500A (en) 2001-05-10

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