WO2001023410A3 - Drug target isogenes: polymorphisms in the interleukin 13 gene - Google Patents

Drug target isogenes: polymorphisms in the interleukin 13 gene Download PDF

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Publication number
WO2001023410A3
WO2001023410A3 PCT/US2000/026556 US0026556W WO0123410A3 WO 2001023410 A3 WO2001023410 A3 WO 2001023410A3 US 0026556 W US0026556 W US 0026556W WO 0123410 A3 WO0123410 A3 WO 0123410A3
Authority
WO
WIPO (PCT)
Prior art keywords
gene
polymorphisms
interleukin
drug target
isogenes
Prior art date
Application number
PCT/US2000/026556
Other languages
French (fr)
Other versions
WO2001023410A2 (en
Inventor
Anne Chew
R Rex Denton
Krishnan Nandabalan
Joel Claiborne Stephens
Original Assignee
Genaissance Pharmaceuticals
Anne Chew
R Rex Denton
Krishnan Nandabalan
Joel Claiborne Stephens
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genaissance Pharmaceuticals, Anne Chew, R Rex Denton, Krishnan Nandabalan, Joel Claiborne Stephens filed Critical Genaissance Pharmaceuticals
Publication of WO2001023410A2 publication Critical patent/WO2001023410A2/en
Publication of WO2001023410A3 publication Critical patent/WO2001023410A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Abstract

Polynucleotides comprising one or more of 14 novel single nucleotide polymorphisms in the human interleukin 13 (IL13) gene are described. Compositions and methods for detecting one or more of these polymorphisms are also disclosed. In addition, various genotypes and haplotypes for IL13 gene that exist in the population are described.
PCT/US2000/026556 1999-09-28 2000-09-27 Drug target isogenes: polymorphisms in the interleukin 13 gene WO2001023410A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15648999P 1999-09-28 1999-09-28
US60/156,489 1999-09-28

Publications (2)

Publication Number Publication Date
WO2001023410A2 WO2001023410A2 (en) 2001-04-05
WO2001023410A3 true WO2001023410A3 (en) 2003-03-13

Family

ID=22559792

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/026556 WO2001023410A2 (en) 1999-09-28 2000-09-27 Drug target isogenes: polymorphisms in the interleukin 13 gene

Country Status (2)

Country Link
AU (1) AU2000278349A1 (en)
WO (1) WO2001023410A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA01006006A (en) 1998-12-14 2004-08-12 Genetics Inst Cytokine receptor chain.
US7553487B2 (en) 1998-12-14 2009-06-30 Genetics Institute, Llc Method and compositions for treating asthma
US7205106B1 (en) 2001-07-20 2007-04-17 Roche Molecular Systems, Inc. Association of polymorphisms in IL4-related genes with autoimmune disease
WO2003016346A1 (en) * 2001-08-17 2003-02-27 Hitachi Chemical Co., Ltd. Ligands
CA2441701C (en) * 2002-10-04 2010-07-13 F. Hoffmann-La Roche Ag Detection of il4 and il13 polymorphisms in determination of type 1 diabetes susceptibility
AR049390A1 (en) 2004-06-09 2006-07-26 Wyeth Corp ANTIBODIES AGAINST HUMAN INTERLEUQUINE-13 AND USES OF THE SAME
US7501121B2 (en) 2004-06-17 2009-03-10 Wyeth IL-13 binding agents
US8399630B2 (en) 2008-08-20 2013-03-19 Centocor Ortho Biotech Inc. Engineered anti-IL-13 antibodies, compositions, methods and uses

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5595890A (en) * 1988-03-10 1997-01-21 Zeneca Limited Method of detecting nucleotide sequences

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5595890A (en) * 1988-03-10 1997-01-21 Zeneca Limited Method of detecting nucleotide sequences

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE GENBANK [online] NATIONAL CENTER FOR BIOTECH INFORMATION AT NIH, (BEHESDA, MD, USA); 17 January 1998 (1998-01-17), CONNOLLY K.S. ET AL., XP002954340, Database accession no. (AC004039) *
DATABASE GENBANK [online] NATIONAL CENTER FOR BIOTECH INFORMATION AT NIH, (BETHESDA, MD, USA); 10 May 1995 (1995-05-10), MARTIN CH. ET AL., XP002954341, Database accession no. (L42080) *

Also Published As

Publication number Publication date
WO2001023410A2 (en) 2001-04-05
AU2000278349A8 (en) 2001-06-28
AU2000278349A1 (en) 2001-04-30

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