WO2001027311A3 - Drug target isogenes: polymorphisms in the 5-hydroxytryptamine (serotonin) receptor 1d gene - Google Patents

Drug target isogenes: polymorphisms in the 5-hydroxytryptamine (serotonin) receptor 1d gene Download PDF

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Publication number
WO2001027311A3
WO2001027311A3 PCT/US2000/028115 US0028115W WO0127311A3 WO 2001027311 A3 WO2001027311 A3 WO 2001027311A3 US 0028115 W US0028115 W US 0028115W WO 0127311 A3 WO0127311 A3 WO 0127311A3
Authority
WO
WIPO (PCT)
Prior art keywords
gene
polymorphisms
hydroxytryptamine
serotonin
receptor
Prior art date
Application number
PCT/US2000/028115
Other languages
French (fr)
Other versions
WO2001027311A2 (en
Inventor
Julie Y Choi
R Rex Denton
Krishnan Nandabalan
J Claiborne Stephens
Original Assignee
Genaissance Pharmaceuticals
Julie Y Choi
R Rex Denton
Krishnan Nandabalan
J Claiborne Stephens
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genaissance Pharmaceuticals, Julie Y Choi, R Rex Denton, Krishnan Nandabalan, J Claiborne Stephens filed Critical Genaissance Pharmaceuticals
Priority to PCT/US2000/028115 priority Critical patent/WO2001027311A2/en
Priority to AU2001213316A priority patent/AU2001213316A1/en
Publication of WO2001027311A2 publication Critical patent/WO2001027311A2/en
Publication of WO2001027311A3 publication Critical patent/WO2001027311A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Abstract

Polynucleotides comprising one or both of 2 novel single nucleotide polymorphisms in the human 5-hydroxytryptamine (serotonin) receptor 1D (HTR1D) gene are described. Compositions and methods for detecting one or more of these polymorphisms are also disclosed. In addition, various genotypes and haplotypes for the HTR1D gene that exist in the population are described.
PCT/US2000/028115 1999-10-13 2000-10-12 Drug target isogenes: polymorphisms in the 5-hydroxytryptamine (serotonin) receptor 1d gene WO2001027311A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/US2000/028115 WO2001027311A2 (en) 1999-10-13 2000-10-12 Drug target isogenes: polymorphisms in the 5-hydroxytryptamine (serotonin) receptor 1d gene
AU2001213316A AU2001213316A1 (en) 2000-10-12 2000-10-12 Drug target isogenes: polymorphisms in the 5-hydroxytryptamine (serotonin) receptor 1d gene

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60/159,257 1999-10-13
PCT/US2000/028115 WO2001027311A2 (en) 1999-10-13 2000-10-12 Drug target isogenes: polymorphisms in the 5-hydroxytryptamine (serotonin) receptor 1d gene

Publications (2)

Publication Number Publication Date
WO2001027311A2 WO2001027311A2 (en) 2001-04-19
WO2001027311A3 true WO2001027311A3 (en) 2008-03-06

Family

ID=21741878

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/028115 WO2001027311A2 (en) 1999-10-13 2000-10-12 Drug target isogenes: polymorphisms in the 5-hydroxytryptamine (serotonin) receptor 1d gene

Country Status (2)

Country Link
AU (1) AU2001213316A1 (en)
WO (1) WO2001027311A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004537311A (en) * 2001-07-16 2004-12-16 プライス ファンデーション リミテッド Genes and SNPs associated with eating disorders

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
REBECK G.W. ET AL.: "Selective 5-HT1Dalpha serotonin receptor gene expression in trigeminal ganglia: implications for antimigraine drug development", PROC. NATL. ACAD. SCI. USA, vol. 91, April 1994 (1994-04-01), pages 3666 - 3669, XP000604666 *

Also Published As

Publication number Publication date
AU2001213316A1 (en) 2001-04-23
WO2001027311A2 (en) 2001-04-19

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