WO2001022917A2 - Effervescent compositions comprising nimesulide - Google Patents
Effervescent compositions comprising nimesulide Download PDFInfo
- Publication number
- WO2001022917A2 WO2001022917A2 PCT/IN2000/000093 IN0000093W WO0122917A2 WO 2001022917 A2 WO2001022917 A2 WO 2001022917A2 IN 0000093 W IN0000093 W IN 0000093W WO 0122917 A2 WO0122917 A2 WO 0122917A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- pharmaceutical composition
- carbonate
- nimesulide
- acid
- sodium
- Prior art date
Links
- 229960000965 nimesulide Drugs 0.000 title claims abstract description 57
- HYWYRSMBCFDLJT-UHFFFAOYSA-N nimesulide Chemical compound CS(=O)(=O)NC1=CC=C([N+]([O-])=O)C=C1OC1=CC=CC=C1 HYWYRSMBCFDLJT-UHFFFAOYSA-N 0.000 title claims abstract description 57
- 239000000203 mixture Substances 0.000 title claims description 24
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 17
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims abstract description 16
- 229940079593 drug Drugs 0.000 claims abstract description 15
- 239000003814 drug Substances 0.000 claims abstract description 15
- 239000002253 acid Substances 0.000 claims abstract description 11
- 150000007513 acids Chemical class 0.000 claims abstract description 4
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 25
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 22
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 19
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 13
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 13
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 9
- 235000017550 sodium carbonate Nutrition 0.000 claims description 9
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 6
- 235000015165 citric acid Nutrition 0.000 claims description 6
- 239000000796 flavoring agent Substances 0.000 claims description 6
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 4
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 4
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 claims description 4
- 235000003599 food sweetener Nutrition 0.000 claims description 4
- 239000000314 lubricant Substances 0.000 claims description 4
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 4
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 4
- 239000003765 sweetening agent Substances 0.000 claims description 4
- 239000011975 tartaric acid Substances 0.000 claims description 4
- 235000002906 tartaric acid Nutrition 0.000 claims description 4
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- 239000001530 fumaric acid Substances 0.000 claims description 3
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- 239000000546 pharmaceutical excipient Substances 0.000 claims description 3
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 3
- 239000000080 wetting agent Substances 0.000 claims description 3
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 2
- 239000004475 Arginine Substances 0.000 claims description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 2
- 239000004150 EU approved colour Substances 0.000 claims description 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 2
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical group [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 2
- 239000001361 adipic acid Substances 0.000 claims description 2
- 235000011037 adipic acid Nutrition 0.000 claims description 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 2
- OCHFNTLZOZPXFE-JEDNCBNOSA-N carbonic acid;(2s)-2,6-diaminohexanoic acid Chemical compound OC(O)=O.NCCCC[C@H](N)C(O)=O OCHFNTLZOZPXFE-JEDNCBNOSA-N 0.000 claims description 2
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- 239000011736 potassium bicarbonate Substances 0.000 claims description 2
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- 235000015497 potassium bicarbonate Nutrition 0.000 claims description 2
- 229910000027 potassium carbonate Inorganic materials 0.000 claims description 2
- 235000011181 potassium carbonates Nutrition 0.000 claims description 2
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 claims description 2
- 229910000031 sodium sesquicarbonate Inorganic materials 0.000 claims description 2
- 235000018341 sodium sesquicarbonate Nutrition 0.000 claims description 2
- 239000001384 succinic acid Substances 0.000 claims description 2
- 235000011044 succinic acid Nutrition 0.000 claims description 2
- 239000000375 suspending agent Substances 0.000 claims description 2
- WCTAGTRAWPDFQO-UHFFFAOYSA-K trisodium;hydrogen carbonate;carbonate Chemical compound [Na+].[Na+].[Na+].OC([O-])=O.[O-]C([O-])=O WCTAGTRAWPDFQO-UHFFFAOYSA-K 0.000 claims description 2
- 230000006835 compression Effects 0.000 claims 1
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- RRPFCKLVOUENJB-UHFFFAOYSA-L disodium;2-aminoacetic acid;carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O.NCC(O)=O RRPFCKLVOUENJB-UHFFFAOYSA-L 0.000 claims 1
- 238000004806 packaging method and process Methods 0.000 claims 1
- 239000008187 granular material Substances 0.000 description 19
- -1 dicofenac Chemical compound 0.000 description 12
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 12
- 230000000694 effects Effects 0.000 description 10
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- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 8
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- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 6
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- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 5
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU28798/01A AU2879801A (en) | 1999-09-28 | 2000-09-27 | Effervescent compositions comprising nimesulide |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1296DE1999 IN190018B (enrdf_load_html_response) | 1999-09-28 | 1999-09-28 | |
| IN1296/DEL/99 | 1999-09-28 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| WO2001022917A2 true WO2001022917A2 (en) | 2001-04-05 |
| WO2001022917A3 WO2001022917A3 (en) | 2001-12-27 |
| WO2001022917A8 WO2001022917A8 (en) | 2002-06-20 |
Family
ID=11092666
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/IN2000/000093 WO2001022917A2 (en) | 1999-09-28 | 2000-09-27 | Effervescent compositions comprising nimesulide |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU2879801A (enrdf_load_html_response) |
| IN (1) | IN190018B (enrdf_load_html_response) |
| WO (1) | WO2001022917A2 (enrdf_load_html_response) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007010559A3 (en) * | 2005-07-20 | 2007-09-20 | Panacea Biotec Ltd | Novel pharmaceutical modified release dosage form cyclooxygenase enzyme inhibitor |
| EP2015740A4 (en) * | 2006-04-24 | 2009-11-11 | Panacea Biotec Ltd | NEW LOW-DOSED PHARMACEUTICAL COMPOSITIONS WITH NIMESULID, PREPARATION AND USE |
| WO2010029037A1 (fr) * | 2008-09-09 | 2010-03-18 | Europharmaceuticals | Composition de nimesulide orodispersible |
| EP2249776A4 (en) * | 2008-02-08 | 2014-01-08 | Colgate Palmolive Co | SHOWER COMPOSITIONS |
| WO2016116909A3 (en) * | 2015-01-23 | 2016-10-27 | Dr. Reddy's Laboratories Limited | Non-staining topical gel compositions of nimesulide |
| CN114105839A (zh) * | 2020-08-27 | 2022-03-01 | 湖北舒邦药业有限公司 | 一种原料药的前处理方法及其组合物 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1293764B1 (it) * | 1997-07-23 | 1999-03-10 | Chiesi Farma Spa | Composizioni farmaceutiche sotto forma di compresse effervescenti contenenti un principio attivo instabile in presenza di acqua |
| PT1001748E (pt) * | 1997-07-25 | 2006-08-31 | Alpex Pharma Sa | Um processo para a preparacao de um granulado adequado para a preparacao de comprimidos rapidamente desintegraveis na boca |
| IT1298732B1 (it) * | 1998-03-13 | 2000-02-02 | Recordati Chem Pharm | Composizioni farmaceutiche orali assumibili senza liquidi,contenenti complessi di inclusione |
-
1999
- 1999-09-28 IN IN1296DE1999 patent/IN190018B/en unknown
-
2000
- 2000-09-27 AU AU28798/01A patent/AU2879801A/en not_active Abandoned
- 2000-09-27 WO PCT/IN2000/000093 patent/WO2001022917A2/en active Application Filing
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007010559A3 (en) * | 2005-07-20 | 2007-09-20 | Panacea Biotec Ltd | Novel pharmaceutical modified release dosage form cyclooxygenase enzyme inhibitor |
| EP2015740A4 (en) * | 2006-04-24 | 2009-11-11 | Panacea Biotec Ltd | NEW LOW-DOSED PHARMACEUTICAL COMPOSITIONS WITH NIMESULID, PREPARATION AND USE |
| EP2249776A4 (en) * | 2008-02-08 | 2014-01-08 | Colgate Palmolive Co | SHOWER COMPOSITIONS |
| US10959967B2 (en) | 2008-02-08 | 2021-03-30 | Colgate-Palmolive Company | Effervescent compositions |
| WO2010029037A1 (fr) * | 2008-09-09 | 2010-03-18 | Europharmaceuticals | Composition de nimesulide orodispersible |
| BE1018279A3 (fr) * | 2008-09-09 | 2010-08-03 | Squarepoint Pointcarre Sprl | Composition de nimesulide orodispersible. |
| WO2016116909A3 (en) * | 2015-01-23 | 2016-10-27 | Dr. Reddy's Laboratories Limited | Non-staining topical gel compositions of nimesulide |
| CN114105839A (zh) * | 2020-08-27 | 2022-03-01 | 湖北舒邦药业有限公司 | 一种原料药的前处理方法及其组合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2879801A (en) | 2001-04-30 |
| WO2001022917A3 (en) | 2001-12-27 |
| IN190018B (enrdf_load_html_response) | 2003-05-31 |
| WO2001022917A8 (en) | 2002-06-20 |
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