WO2001012668A1 - Peptides derives de la cathelicidine ayant une activite antimicrobienne a large spectre - Google Patents

Peptides derives de la cathelicidine ayant une activite antimicrobienne a large spectre Download PDF

Info

Publication number
WO2001012668A1
WO2001012668A1 PCT/US2000/022781 US0022781W WO0112668A1 WO 2001012668 A1 WO2001012668 A1 WO 2001012668A1 US 0022781 W US0022781 W US 0022781W WO 0112668 A1 WO0112668 A1 WO 0112668A1
Authority
WO
WIPO (PCT)
Prior art keywords
seq
antimicrobial
peptide
lrriirkiihiikk
knirriirkiihiikkyg
Prior art date
Application number
PCT/US2000/022781
Other languages
English (en)
Other versions
WO2001012668A9 (fr
Inventor
Brian F. Tack
Paul B. Mccray, Jr.
Michael Welsh
Sue M. Travis
Robert Lehrer
Original Assignee
University Of Iowa Research Foundation
The Regents Of The University Of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Of Iowa Research Foundation, The Regents Of The University Of California filed Critical University Of Iowa Research Foundation
Priority to AU74704/00A priority Critical patent/AU7470400A/en
Publication of WO2001012668A1 publication Critical patent/WO2001012668A1/fr
Publication of WO2001012668A9 publication Critical patent/WO2001012668A9/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne: l'utilisation de peptides antimicrobiens pour l'inhibition de la croissance et de la prolifération microbienne; des peptides tronqués antimicrobiens se basant sur SMAP 29 et RCAP 18 mais contenant une quantité moindre de résidus d'acides aminés tout en conservant une activité bactéricide; des peptides de synthèse se basant sur la protéine SMAP 29 qui possèdent moins de résidus d'acides aminés et comprennent des substitutions tout en conservant une activité importante; un procédé d'inhibition de la croissance microbienne par administration d'une quantité appropriée d'un peptide de l'invention, ou par combinaison des peptides avec d'autres agents antimicrobiens ou antibiotiques.
PCT/US2000/022781 1999-08-18 2000-08-18 Peptides derives de la cathelicidine ayant une activite antimicrobienne a large spectre WO2001012668A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU74704/00A AU7470400A (en) 1999-08-18 2000-08-18 Cathelicidin-derived peptides with broad spectrum antimicrobial activity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14988699P 1999-08-18 1999-08-18
US60/149,886 1999-08-18

Publications (2)

Publication Number Publication Date
WO2001012668A1 true WO2001012668A1 (fr) 2001-02-22
WO2001012668A9 WO2001012668A9 (fr) 2002-07-18

Family

ID=22532214

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/022781 WO2001012668A1 (fr) 1999-08-18 2000-08-18 Peptides derives de la cathelicidine ayant une activite antimicrobienne a large spectre

Country Status (2)

Country Link
AU (1) AU7470400A (fr)
WO (1) WO2001012668A1 (fr)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002000839A2 (fr) * 2000-06-28 2002-01-03 The Regents Of The University Of California Novispirines: peptides antimicrobiens
WO2002060468A2 (fr) * 2001-01-30 2002-08-08 University Of Iowa Research Foundation Nouvelles activites antivirales de defensines theta de primates et mammaliennes
EP1358888A1 (fr) * 2002-02-28 2003-11-05 Robert Bals L'Antibiotique peptidique humain LL-37/hCAP-18 est un inducteur de l'angiogénèse
WO2004108752A1 (fr) 2003-06-11 2004-12-16 Novozymes A/S Polypeptides antimicrobiens
WO2005105831A1 (fr) * 2004-05-04 2005-11-10 Novozymes A/S Polypeptides antimicrobiens
US7351693B2 (en) 2002-01-25 2008-04-01 University Court Of The University Of Aberdeen Peptides and nucleic acids of the cathelicidin family, derived from fish, and uses thereof
EP2404932A1 (fr) * 2009-03-06 2012-01-11 AnGes MG, Inc. Polypeptides et utilisation antibactérienne ou antiseptique de ceux-ci
US8969311B2 (en) 2009-05-25 2015-03-03 Anges Mg, Inc. Polypeptide having antibacterial activity and angiogenesis-inducing activity and wound-healing drug containing said polypeptide
US9376470B2 (en) 2008-11-28 2016-06-28 Funpep Inc. Polypeptide having angiogenesis-inducing activity and antibacterial activity, and use thereof for medical purposes
US9745348B2 (en) 2011-09-14 2017-08-29 The University Of Manchester Short designed peptides possessing selective actions against bacteria and cancer cells

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BALS ROBERT ET AL: "The peptide antibiotic LL-37/hCAP-18 is expressed in epthelia of the human lung where it has broad antimicrobial activity at the airway surface.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 95, no. 16, 4 August 1998 (1998-08-04), Aug. 4, 1998, pages 9541 - 9546, XP002157167, ISSN: 0027-8424 *
HUTTNER K M ET AL: "Localization and genomic organization of sheep antimicrobial peptide genes", GENE: AN INTERNATIONAL JOURNAL ON GENES AND GENOMES,GB,ELSEVIER SCIENCE PUBLISHERS, BARKING, vol. 206, no. 1, 5 January 1998 (1998-01-05), pages 85 - 91, XP004102876, ISSN: 0378-1119 *
MERLUZZI, LAURA ET AL.: "BIOLOGICAL ACTIVITY OF A NOVEL CATHELICIDIN-DERIVED ANTIMICROBIAL PEPTIDE FROM SHEEP", PEPT 1996 PROC EUR PEPT SYMP 24TH (1998) MEETING DATE 1996 639-640 EDITOR(S) RAMAGE ROBERT EPTON ROGER PUBLISHER MAYFLOWER SCIENTIFIC KINGSWINFORD UK, XP002157166 *
TOSSI ALESSANDRO ET AL: "Design of synthetic antimicrobial peptides based on sequence analogy and amphipathicity.", EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 250, no. 2, December 1997 (1997-12-01), pages 549 - 558, XP000978718, ISSN: 0014-2956 *
TOSSI ET AL: "Identification and characterization of a primary antibacterial domain in CAP18, a lipopolysaccharide binding protein from rabbit leukocytes", FEBS LETTERS,NL,ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, vol. 339, no. 1/02, 1994, pages 108 - 112, XP002083170, ISSN: 0014-5793 *
TRAVIS, SUE M. ET AL.: "BACTERICIDAL ACTIVITY OF MAMMALIAN CATHELICIDIN-DERIVED PEPTIDES", INFECT IMMUN (2000) 68(5) 2748-2755, XP002157165 *

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002000839A2 (fr) * 2000-06-28 2002-01-03 The Regents Of The University Of California Novispirines: peptides antimicrobiens
WO2002000839A3 (fr) * 2000-06-28 2003-08-28 Univ California Novispirines: peptides antimicrobiens
EP1359930A2 (fr) * 2000-06-28 2003-11-12 The Regents Of The University Of California Novispirines: peptides antimicrobiens
EP1359930A4 (fr) * 2000-06-28 2004-07-14 Univ California Novispirines: peptides antimicrobiens
WO2002060468A2 (fr) * 2001-01-30 2002-08-08 University Of Iowa Research Foundation Nouvelles activites antivirales de defensines theta de primates et mammaliennes
WO2002060468A3 (fr) * 2001-03-30 2003-01-23 Univ Iowa Res Found Nouvelles activites antivirales de defensines theta de primates et mammaliennes
US7351693B2 (en) 2002-01-25 2008-04-01 University Court Of The University Of Aberdeen Peptides and nucleic acids of the cathelicidin family, derived from fish, and uses thereof
EP1358888A1 (fr) * 2002-02-28 2003-11-05 Robert Bals L'Antibiotique peptidique humain LL-37/hCAP-18 est un inducteur de l'angiogénèse
WO2004108752A1 (fr) 2003-06-11 2004-12-16 Novozymes A/S Polypeptides antimicrobiens
US7829524B2 (en) 2003-06-11 2010-11-09 Novozymes Adenium Biotech A/S Antimicrobial peptides
US7504375B2 (en) 2004-05-04 2009-03-17 Novozymes A/S Antimicrobial polypeptides
WO2005105831A1 (fr) * 2004-05-04 2005-11-10 Novozymes A/S Polypeptides antimicrobiens
EP2267000A3 (fr) * 2004-05-04 2011-07-06 Novozymes Adenium Biotech A/S Polypeptides antimicrobiens
AU2005238127B2 (en) * 2004-05-04 2011-08-18 Novozymes Adenium Biotech A/S Antimicrobial polypeptides
US8080390B2 (en) 2004-05-04 2011-12-20 Novozymes Adenium Biotech A/S Antimicrobial polypeptides
US9376470B2 (en) 2008-11-28 2016-06-28 Funpep Inc. Polypeptide having angiogenesis-inducing activity and antibacterial activity, and use thereof for medical purposes
EP2404932A1 (fr) * 2009-03-06 2012-01-11 AnGes MG, Inc. Polypeptides et utilisation antibactérienne ou antiseptique de ceux-ci
EP2404932A4 (fr) * 2009-03-06 2012-11-07 Anges Mg Inc Polypeptides et utilisation antibactérienne ou antiseptique de ceux-ci
US8470765B2 (en) 2009-03-06 2013-06-25 Anges Mg, Inc. Polypeptides and antibacterial or antiseptic use of same
US8969311B2 (en) 2009-05-25 2015-03-03 Anges Mg, Inc. Polypeptide having antibacterial activity and angiogenesis-inducing activity and wound-healing drug containing said polypeptide
US9695219B2 (en) 2009-05-25 2017-07-04 Funpep Inc. Polypeptide having antibacterial activity and angiogenesis-inducing activity and wound-healing drug containing said polypeptide
US9745348B2 (en) 2011-09-14 2017-08-29 The University Of Manchester Short designed peptides possessing selective actions against bacteria and cancer cells

Also Published As

Publication number Publication date
WO2001012668A9 (fr) 2002-07-18
AU7470400A (en) 2001-03-13

Similar Documents

Publication Publication Date Title
US7390873B2 (en) Antimicrobial cationic peptides
WO2002060468A2 (fr) Nouvelles activites antivirales de defensines theta de primates et mammaliennes
US5804445A (en) High affinity mutants of nuclear factor-interleukin 6 and methods of use therefor
JP2004514644A (ja) 抗菌化合物および処方物
JP4849764B2 (ja) 抗微生物ペプチドおよびそれらの使用法
US7071293B1 (en) Alpha helical peptides with broad spectrum antimicrobial activity that are insensitive to salt
JP2008534686A (ja) 黄色ブドウ球菌感染の処置におけるｒｉｐの使用
WO2001012668A1 (fr) Peptides derives de la cathelicidine ayant une activite antimicrobienne a large spectre
JP4902919B2 (ja) ペプチド作成の方法
CA2200069C (fr) Peptides antifongiques
TW201028154A (en) Antibiotic synergism
JP4651213B2 (ja) インフルエンザウイルス・ヘマグルチニン結合性ペプチド
US20060217306A1 (en) Systemic treatment of infections with defensins
Cárdenas-Martínez et al. Effects of substituting arginine by lysine in bovine lactoferricin derived peptides: pursuing production lower costs, lower hemolysis, and sustained antimicrobial activity
EP2170932A1 (fr) Compositions et leurs utilisations dans le traitement du syndrome de détresse respiratoire aigu (ards) et de troubles cliniques associés à celui-ci
WO2018115877A2 (fr) Compositions et méthodes de traitement
US20050192221A1 (en) Methods and compositions related to plunc polypeptides
US8796323B2 (en) Defensin-like molecules as novel antimicrobial agents
WO2008104777A2 (fr) Peptide
JPH06504260A (ja) 両親媒性ペプチド組成物及びその類似体
AU2001267234B2 (en) Antimicrobial peptides and methods of use thereof
AU2001267234A1 (en) Antimicrobial peptides and methods of use thereof

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: C2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: C2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

COP Corrected version of pamphlet

Free format text: PAGES 3-106, DESCRIPTION, REPLACED BY NEW PAGES 1-100; PAGES 107-117, CLAIMS, REPLACED BY NEW PAGES101-110; PAGES 1/13-13/13, DRAWINGS, REPLACED BY NEW PAGES 1/21-21/21; PAGES 1-7, SEQUENCE LISTING, REPLACED BY NEW PAGES 1-7; DUE TO LATE TRANSMITTAL BY THE RECEIVING OFFICE

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP