WO2001012668A9 - Peptides derives de la cathelicidine ayant une activite antimicrobienne a large spectre - Google Patents

Peptides derives de la cathelicidine ayant une activite antimicrobienne a large spectre

Info

Publication number
WO2001012668A9
WO2001012668A9 PCT/US2000/022781 US0022781W WO0112668A9 WO 2001012668 A9 WO2001012668 A9 WO 2001012668A9 US 0022781 W US0022781 W US 0022781W WO 0112668 A9 WO0112668 A9 WO 0112668A9
Authority
WO
WIPO (PCT)
Prior art keywords
peptides
cathelicidin
antimicrobial activity
broad spectrum
derived peptides
Prior art date
Application number
PCT/US2000/022781
Other languages
English (en)
Other versions
WO2001012668A1 (fr
Inventor
Brian F Tack
Paul B Mccray Jr
Michael Welsh
Sue M Travis
Robert Lehrer
Original Assignee
Univ Iowa Res Found
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Iowa Res Found, Univ California filed Critical Univ Iowa Res Found
Priority to AU74704/00A priority Critical patent/AU7470400A/en
Publication of WO2001012668A1 publication Critical patent/WO2001012668A1/fr
Publication of WO2001012668A9 publication Critical patent/WO2001012668A9/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne: l'utilisation de peptides antimicrobiens pour l'inhibition de la croissance et de la prolifération microbienne; des peptides tronqués antimicrobiens se basant sur SMAP 29 et RCAP 18 mais contenant une quantité moindre de résidus d'acides aminés tout en conservant une activité bactéricide; des peptides de synthèse se basant sur la protéine SMAP 29 qui possèdent moins de résidus d'acides aminés et comprennent des substitutions tout en conservant une activité importante; un procédé d'inhibition de la croissance microbienne par administration d'une quantité appropriée d'un peptide de l'invention, ou par combinaison des peptides avec d'autres agents antimicrobiens ou antibiotiques.
PCT/US2000/022781 1999-08-18 2000-08-18 Peptides derives de la cathelicidine ayant une activite antimicrobienne a large spectre WO2001012668A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU74704/00A AU7470400A (en) 1999-08-18 2000-08-18 Cathelicidin-derived peptides with broad spectrum antimicrobial activity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14988699P 1999-08-18 1999-08-18
US60/149,886 1999-08-18

Publications (2)

Publication Number Publication Date
WO2001012668A1 WO2001012668A1 (fr) 2001-02-22
WO2001012668A9 true WO2001012668A9 (fr) 2002-07-18

Family

ID=22532214

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/022781 WO2001012668A1 (fr) 1999-08-18 2000-08-18 Peptides derives de la cathelicidine ayant une activite antimicrobienne a large spectre

Country Status (2)

Country Link
AU (1) AU7470400A (fr)
WO (1) WO2001012668A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0112035A (pt) * 2000-06-28 2006-02-21 Univ California peptìdeos antimicrobianos de novispirin
WO2002060468A2 (fr) * 2001-01-30 2002-08-08 University Of Iowa Research Foundation Nouvelles activites antivirales de defensines theta de primates et mammaliennes
DE60330116D1 (de) 2002-01-25 2009-12-31 Univ Aberdeen Aberdeen Aus fisch gewonnene peptide und nukleinsäuren der cathelicidin familie und deren verwendung
EP1358888A1 (fr) * 2002-02-28 2003-11-05 Robert Bals L'Antibiotique peptidique humain LL-37/hCAP-18 est un inducteur de l'angiogénèse
PT1664096E (pt) 2003-06-11 2010-01-08 Novozymes Adenium Biotech As Polipeptídeos antimicromianos
US7148404B2 (en) 2004-05-04 2006-12-12 Novozymes A/S Antimicrobial polypeptides
EP2371840B1 (fr) 2008-11-28 2014-04-16 AnGes MG, Inc. Nouveau polypeptide avec activités d'induction d'angiogenèse et antibactérienne, et son utilisation à des fins médicales
WO2010101237A1 (fr) 2009-03-06 2010-09-10 アンジェスＭｇ株式会社 Polypeptides et utilisation antibactérienne ou antiseptique de ceux-ci
JP5750766B2 (ja) 2009-05-25 2015-07-22 株式会社ファンペップ 血管新生誘導活性及び抗菌活性を有するポリペプチドおよびそれを含有する創傷治療剤
GB201115910D0 (en) 2011-09-14 2011-10-26 Univ Manchester Peptides

Also Published As

Publication number Publication date
AU7470400A (en) 2001-03-13
WO2001012668A1 (fr) 2001-02-22

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