WO2000067547A2 - Procede de detection de serum et de determination de sa qualite, et dispositifs correspondant - Google Patents

Procede de detection de serum et de determination de sa qualite, et dispositifs correspondant Download PDF

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Publication number
WO2000067547A2
WO2000067547A2 PCT/CH2000/000431 CH0000431W WO0067547A2 WO 2000067547 A2 WO2000067547 A2 WO 2000067547A2 CH 0000431 W CH0000431 W CH 0000431W WO 0067547 A2 WO0067547 A2 WO 0067547A2
Authority
WO
WIPO (PCT)
Prior art keywords
container
serum
spectrum
blood
wavelengths
Prior art date
Application number
PCT/CH2000/000431
Other languages
German (de)
English (en)
Other versions
WO2000067547A3 (fr
Inventor
Heinz Wagner
Martin Labhart
Original Assignee
Optan Ag Mess- U. Analysegeräte
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Optan Ag Mess- U. Analysegeräte filed Critical Optan Ag Mess- U. Analysegeräte
Priority to AU2000264217A priority Critical patent/AU2000264217A1/en
Publication of WO2000067547A2 publication Critical patent/WO2000067547A2/fr
Publication of WO2000067547A3 publication Critical patent/WO2000067547A3/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F23/00—Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm
    • G01F23/22—Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm by measuring physical variables, other than linear dimensions, pressure or weight, dependent on the level to be measured, e.g. by difference of heat transfer of steam or water
    • G01F23/28—Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm by measuring physical variables, other than linear dimensions, pressure or weight, dependent on the level to be measured, e.g. by difference of heat transfer of steam or water by measuring the variations of parameters of electromagnetic or acoustic waves applied directly to the liquid or fluent solid material
    • G01F23/284—Electromagnetic waves
    • G01F23/292—Light, e.g. infrared or ultraviolet
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F23/00—Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm
    • G01F23/22—Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm by measuring physical variables, other than linear dimensions, pressure or weight, dependent on the level to be measured, e.g. by difference of heat transfer of steam or water
    • G01F23/28—Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm by measuring physical variables, other than linear dimensions, pressure or weight, dependent on the level to be measured, e.g. by difference of heat transfer of steam or water by measuring the variations of parameters of electromagnetic or acoustic waves applied directly to the liquid or fluent solid material
    • G01F23/284—Electromagnetic waves
    • G01F23/292—Light, e.g. infrared or ultraviolet
    • G01F23/2921—Light, e.g. infrared or ultraviolet for discrete levels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G01N21/3577—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing liquids, e.g. polluted water
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G01N21/359—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light

Definitions

  • the present invention relates to a method for detecting serum according to the preamble of claim 1, a method for detecting the quality of blood serum according to that of claim 2 and arrangements therefor according to claims 7 and 8 respectively.
  • Blood test tubes are labeled by the manufacturers with a label with information about specified ingredients etc. and provided with a patient code - usually a barcode - by the user.
  • the labels largely obscure the view of the content, often also completely.
  • an automatic analysis by means of an automat requires information about the available amount of the serum in the blood sample tube examined in each case, as well as information regarding the quality of the serum, i.e. Concentration values of fat, blood pigment and bilirubin in order to exclude incorrect results in certain tests in advance.
  • the latter contains light containing at least parts of the spectrum S.
  • the required partial transparency relates in particular to the wavelengths or bands used in the context of the invention and as will be explained below.
  • the intensity of the transmitted or transflected light is also measured at at least two wavelengths, for which the following applies:
  • transflected light as light, which transmits through the container wall, the container contents, i.e. is reflected on the opposite wall of the container, or also by transmission, and reflects back through content and wall: In any case, the light radiation is always transmitted at least once through the contents of the container and at least twice through the walls of the container.
  • the intensities mentioned are recorded at a predetermined or predeterminable location on the container, and it is further concluded that the presence / absence of serum at the examined location of the container is based on these intensity measurements.
  • the intensity of the transmitted or transflected radiation centered in the spectral bands mentioned with respect to ⁇ i and ⁇ 2 , uniquely identifies the presence or absence of serum at the examined container site, regardless of the material the container is therefore independent of whether a blood sample tube preferably used as a container is made of plastic, glass, etc., is further labeled or not or is labeled or not, provided, of course, the wall transmits light at ⁇ x and ⁇ 2 .
  • concentrations of blood pigment and bilirubin can be determined in the visible range of the light spectrum using known methods.
  • the same spectral bands or frequencies are sometimes used for the quality detection of the blood serum and for the detection of blood serum itself in the respective container to investigate, so that the two methods can be ideally combined, especially with a view to the automatic detection of in-line containers or blood test tubes, the significance of the quality detection increases due to the fact that intensity values are recorded on more than two of the specified frequency bands and be evaluated.
  • the intensity detection is shifted relative to the container, and if necessary the quality detection is carried out at the same time, results in an actual level measurement method or serum quantity measurement method or a method that To determine the quality of the serum.
  • measured intensity values at the specific wavelengths ⁇ 1 ⁇ 2 or ⁇ 3 , ⁇ 4 actual state vectors result, depending on the number of measured wavelength-specific intensities, in two or more dimensions.
  • the measured intensity values are preferably weighted in the sense of an axis scaling in the vector spaces mentioned.
  • the spectral ranges measured at the measured areas may also differ
  • Intensity of the incident light is taken into account or differences in the transmission of the filters used.
  • Fig. 6 in the form of a signal flow / functional block diagram, a system according to the invention.
  • FIG. 7 in the form of a signal flow / functional block diagram, a first embodiment of the system according to FIG. 6 with beam splitter;
  • the tube 1 shows a blood sample tube 1 with the phase separation of the blood into serum 3, gel 5 and blood cake 7 which is carried out for analysis.
  • the tube 1 usually consists of transparent material such as glass or plastic and is (not shown) provided with a label .
  • FIG. 2 typical absorpti curves of blood gel (a), blood cake (b) and blood serum (c) are shown.
  • two-dimensional or multidimensional areas can be defined, which identify the serum quality, and the quality of a serum sample can be identified by measuring these intensities, by comparing the measured vector with the vector space areas mentioned. By measuring the intensity at more than two of the wavelengths mentioned, the serum qualities can be analyzed more precisely.
  • FIG. 6 shows a system according to the invention in the form of a function block / signal flow diagram, in a minimal configuration, which is equally suitable for the design of tection of serum or the detection of the serum level in a blood sample tube or the quality of the serum.
  • a blood sample tube 1 to be examined is irradiated with light in the near infrared range, namely containing at least parts of the spectral range from 1000 nm to 1400 nm, from a schematically represented source 9.
  • the radiation emitted by tubes with labels, lettering etc. and the blood phases is collected in at least two measuring channels 10a and 10b.
  • filters preferably interference filters 12a and 12b, for serum detection at least approximated with the center wavelengths ⁇ i and ⁇ 2 , for serum quality detection with the above-defined center wavelengths ⁇ 3 , ⁇ 4 .
  • Filters with a bandwidth of at most 200 nm, preferably even at most 100 nm, are preferably used.
  • the intensity of the light transmitted on the output side of the filters 12a or 12b is converted into electrical signals by means of optoelectric converters 14a or 14b and fed to each weighting or amplification unit 16a or 16b, the weighting being achieved in that either the amplifications are compared or the intensity measurement values are each divided by reference intensity measurement values, which are measured when the optical beam path is empty, for example between the tubes.
  • the electrical signals corresponding to the weighted intensity values are then fed to an evaluation unit with arithmetic unit 18, which feeds the input signals together offset.
  • the computing unit 18 determines the vector I ⁇ m / l 2 / l 3m currently measured on the sample - by comparison with an or several pre- Mean TARGET areas B S0LL are the output of the calculation or. Evaluation unit 18 outputs signals which indicate the presence of serum or which are representative of the quality of the serum present. For the level or serum quantity measurement in the blood sample tube 1, the latter is shifted in the direction y shown in FIG. 6 relative to the light beam transmission and from the output signal of the computing unit 18, which is meaningful for the presence / absence of serum, the level or the level difference and so that the amount of serum in the
  • Blood sample tube 1 determined.
  • the arrangement shown schematically is excellently suited for an automatic in-line examination of filled blood sample tubes which occur in rapid succession.
  • the blood sample tubes 1, as shown schematically at 20 are moved in rapid succession through the detection light barrier on a conveyor, such as a belt conveyor or carousel.
  • the cycle length of individual measuring cycles is very short, so that, of course, clocked, but also continuously, the blood sample tubes can be moved through the measuring light barrier. With a correspondingly fast computing capacity, the cycle length is approx. 1 - 5 seconds.
  • FIG. 7 shows the arrangement analogous to that of FIG. 6, working with a beam splitter 20.
  • the channels on the output side of the beam splitter 20 are provided according to FIGS. 10a and 10b.
  • the filtering functions according to the filter elements 12a and 12b and beam splitting on the beam splitter 20 can at least partially be combined at least in part by appropriate design of thin-film systems.
  • the transmitted light beam T is controlled by a controllable filter Order 12 c sent before it strikes the optoelectric transducer arrangement 14 c .
  • the schematically entered control S sequentially activates one or the other filtering according to the filters 12 a and 1-2 b of FIG. 6 in the illustrated single beam path to the optoelectric converter 14 c .
  • this is achieved by mechanically inserting one or the other of the filter elements 12 a or 12 into the beam path mechanically, as represented by the double arrow F.
  • the double arrow F the filter elements 12 a or 12 into the beam path mechanically
  • Design expenditure for the arrangement according to the invention is reduced by practically half compared to an embodiment with channels operated in parallel.

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  • Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Electromagnetism (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Thermal Sciences (AREA)
  • Fluid Mechanics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

L'invention a pour objet la détection d'un sérum dans un récipient (1) dont la paroi est au moins partiellement transparente dans un domaine spectral donné. Selon l'invention, le récipient est soumis à un rayonnement lumineux (9) et l'intensité du rayonnement transmis est mesurée pour au moins deux longueurs d'onde lambda prédéterminées. Cette mesure d'intensité permet de déterminer la présence ou l'absence de sérum au niveau de la partie du récipient ayant été soumise au rayonnement.
PCT/CH2000/000431 2000-01-31 2000-08-14 Procede de detection de serum et de determination de sa qualite, et dispositifs correspondant WO2000067547A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2000264217A AU2000264217A1 (en) 2000-01-31 2000-08-14 Method for detecting serum and for determining the quality thereof, and corresponding devices

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH00183/00A CH695000A5 (de) 2000-01-31 2000-01-31 Verfahren zur Detektion von Serum und zur Erfassung seiner Qualitaet und Anordnungen hierzu.
CH183/00 2000-01-31

Publications (2)

Publication Number Publication Date
WO2000067547A2 true WO2000067547A2 (fr) 2000-11-16
WO2000067547A3 WO2000067547A3 (fr) 2001-03-15

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CH (1) CH695000A5 (fr)
WO (1) WO2000067547A2 (fr)

Cited By (13)

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Publication number Priority date Publication date Assignee Title
US7473897B2 (en) 2001-09-12 2009-01-06 Tecan Trading Ag System, method, and computer program for conducting optical transmission measurements and evaluating determined measuring variables
US8840848B2 (en) 2010-07-23 2014-09-23 Beckman Coulter, Inc. System and method including analytical units
US8973736B2 (en) 2011-11-07 2015-03-10 Beckman Coulter, Inc. Magnetic damping for specimen transport system
US9046506B2 (en) 2011-11-07 2015-06-02 Beckman Coulter, Inc. Specimen container detection
US9248982B2 (en) 2011-05-13 2016-02-02 Beckman Coulter, Inc. System and method including laboratory product transport element
US9446418B2 (en) 2011-11-07 2016-09-20 Beckman Coulter, Inc. Robotic arm
US9459273B2 (en) 2011-05-13 2016-10-04 Beckman Coulter, Inc. Laboratory product transport element and path arrangement
US9482684B2 (en) 2011-11-07 2016-11-01 Beckman Coulter, Inc. Centrifuge system and workflow
US9506943B2 (en) 2011-11-07 2016-11-29 Beckman Coulter, Inc. Aliquotter system and workflow
US9534885B2 (en) 2013-02-21 2017-01-03 Roche Diagnostics Operations, Inc. Apparatus for determining a vertical position of at least one interface between a first component and at least one second component and laboratory automation system
US9588038B2 (en) 2012-09-14 2017-03-07 Beckman Coulter, Inc. Analytical system with capillary transport
US9910054B2 (en) 2011-11-07 2018-03-06 Beckman Coulter, Inc. System and method for processing samples
US20210309554A1 (en) * 2018-08-21 2021-10-07 Corning Incorporated Apparatus and methods for manufacturing a glass ribbon

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EP0476192A2 (fr) * 1989-09-18 1992-03-25 The Board Of Regents Of The University Of Washington Méthode pour caractériser un matériau d'origine biologique, par utilisation de la spectroscopie dans l'infrarouge proche
EP0631137A2 (fr) * 1993-06-25 1994-12-28 Edward W. Stark Méthode et appareil pour la mesure de substances apparentées au glucose
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US5817007A (en) * 1993-07-30 1998-10-06 Bang & Olufsen Technology A/S Method and an apparatus for determining the content of a constituent of blood of an individual

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Publication number Priority date Publication date Assignee Title
EP0476192A2 (fr) * 1989-09-18 1992-03-25 The Board Of Regents Of The University Of Washington Méthode pour caractériser un matériau d'origine biologique, par utilisation de la spectroscopie dans l'infrarouge proche
US5455177A (en) * 1992-02-05 1995-10-03 Boehringer Mannheim Gmbh Method for analysis of a medical sample
US5792050A (en) * 1992-07-06 1998-08-11 Alam; Mary K. Near-infrared noninvasive spectroscopic determination of pH
EP0631137A2 (fr) * 1993-06-25 1994-12-28 Edward W. Stark Méthode et appareil pour la mesure de substances apparentées au glucose
US5817007A (en) * 1993-07-30 1998-10-06 Bang & Olufsen Technology A/S Method and an apparatus for determining the content of a constituent of blood of an individual
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Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7473897B2 (en) 2001-09-12 2009-01-06 Tecan Trading Ag System, method, and computer program for conducting optical transmission measurements and evaluating determined measuring variables
US9285382B2 (en) 2010-07-23 2016-03-15 Beckman Coulter, Inc. Reaction vessel
US9274132B2 (en) 2010-07-23 2016-03-01 Beckman Coulter, Inc. Assay cartridge with reaction well
US8932541B2 (en) 2010-07-23 2015-01-13 Beckman Coulter, Inc. Pipettor including compliant coupling
US9519000B2 (en) 2010-07-23 2016-12-13 Beckman Coulter, Inc. Reagent cartridge
US8962308B2 (en) 2010-07-23 2015-02-24 Beckman Coulter, Inc. System and method including thermal cycler modules
US8996320B2 (en) 2010-07-23 2015-03-31 Beckman Coulter, Inc. System and method including analytical units
US9046455B2 (en) 2010-07-23 2015-06-02 Beckman Coulter, Inc. System and method including multiple processing lanes executing processing protocols
US8956570B2 (en) 2010-07-23 2015-02-17 Beckman Coulter, Inc. System and method including analytical units
US9140715B2 (en) 2010-07-23 2015-09-22 Beckman Coulter, Inc. System and method for controlling thermal cycler modules
US8840848B2 (en) 2010-07-23 2014-09-23 Beckman Coulter, Inc. System and method including analytical units
US9658239B2 (en) 2011-05-13 2017-05-23 Beckman Coulter, Inc. Laboratory product transport element and path arrangement
US9459273B2 (en) 2011-05-13 2016-10-04 Beckman Coulter, Inc. Laboratory product transport element and path arrangement
US10473676B2 (en) 2011-05-13 2019-11-12 Beckman Coulter, Inc. Laboratory product transport element and path arrangement
US9248982B2 (en) 2011-05-13 2016-02-02 Beckman Coulter, Inc. System and method including laboratory product transport element
US9910054B2 (en) 2011-11-07 2018-03-06 Beckman Coulter, Inc. System and method for processing samples
US9506943B2 (en) 2011-11-07 2016-11-29 Beckman Coulter, Inc. Aliquotter system and workflow
US9482684B2 (en) 2011-11-07 2016-11-01 Beckman Coulter, Inc. Centrifuge system and workflow
US8973736B2 (en) 2011-11-07 2015-03-10 Beckman Coulter, Inc. Magnetic damping for specimen transport system
US9046506B2 (en) 2011-11-07 2015-06-02 Beckman Coulter, Inc. Specimen container detection
US10048284B2 (en) 2011-11-07 2018-08-14 Beckman Coulter, Inc. Sample container cap with centrifugation status indicator device
US10274505B2 (en) 2011-11-07 2019-04-30 Beckman Coulter, Inc. Robotic arm
EP2776845B1 (fr) * 2011-11-07 2020-11-04 Beckman Coulter, Inc. Bras robotique
US9446418B2 (en) 2011-11-07 2016-09-20 Beckman Coulter, Inc. Robotic arm
US9588038B2 (en) 2012-09-14 2017-03-07 Beckman Coulter, Inc. Analytical system with capillary transport
US9534885B2 (en) 2013-02-21 2017-01-03 Roche Diagnostics Operations, Inc. Apparatus for determining a vertical position of at least one interface between a first component and at least one second component and laboratory automation system
US20210309554A1 (en) * 2018-08-21 2021-10-07 Corning Incorporated Apparatus and methods for manufacturing a glass ribbon

Also Published As

Publication number Publication date
AU2000264217A1 (en) 2000-11-21
CH695000A5 (de) 2005-10-31
WO2000067547A3 (fr) 2001-03-15

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