WO2000062751A2 - Compositions contenant des extraits de boswellia - Google Patents
Compositions contenant des extraits de boswellia Download PDFInfo
- Publication number
- WO2000062751A2 WO2000062751A2 PCT/GB2000/001396 GB0001396W WO0062751A2 WO 2000062751 A2 WO2000062751 A2 WO 2000062751A2 GB 0001396 W GB0001396 W GB 0001396W WO 0062751 A2 WO0062751 A2 WO 0062751A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- extract
- boswellia
- composition
- product
- derivative
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Definitions
- the invention relates to compositions comprising at least one Boswellia extract, or at least one boswellic acid or derivative thereof.
- Boswellia family of plants including Boswellia Serrata can produce a soothing effect to irritated skin and mucous membranes and that this activity is due to the terpenoid compounds grouped under the general name 'boswellic acids'.
- the different boswellic acids share the same basic pentacyclic triterpene (steroid- like) structure but differ in their side groupings.
- JP 10114671 describes compositions such as a mouthwash comprising a Boswellia extract, where the Boswellia extract is stated to be a cell stimulant.
- Typical extracts of Boswellia plants are solids or powders with a wide melting point range, normally above 80°C.
- an extract of a Boswellia plant containing boswellic acids or derivatives thereof, or the boswellic acids or derivatives thereof themselves need to be formulated in a suitable carrier. Although they can be dissolved in solvents such as ethanol or propylene glycol, high levels of these solvents in oral care compositions are inappropriate because of their potential toxicity or intoxicating effects if the compositions are ingested.
- Surfactants are also unsuitable solvents for Boswellia extracts, or boswellic acids or derivatives thereof, because they can often be irritating to the mouth or produce an unpleasant mouth feel.
- Alkalies can produce aqueous solutions of boswellic acids by forming the respective salts.
- highly alkaline compositions are not suitable for oral care use as they may irritate the mouth and could be dangerous if ingested.
- composition suitable for use in the oral cavity comprising;
- a carrier comprising at least one flavour ingredient.
- a composition suitable for use in the oral cavity comprising forming a mixture of:
- a carrier comprising at least one flavour ingredient.
- a product for use in the oral cavity comprising a composition in accordance with the invention.
- a package comprising a composition or product in accordance with the invention; and instructions for use of the composition or product for oral care.
- compositions and products in accordance with the invention may be used to treat inflammation and/or soothe irritation in the mouth of a subject.
- the invention thus also includes within its scope the use of an extract of a Boswellia plant, or at least one boswellic acid or derivative thereof, in preparing a composition for use in oral care, particularly (but not exclusively) for the treatment of inflammation and/or irritation in a human mouth.
- Boswellia is used in this document to refer to at least one extract of a Boswellia plant, or at least one boswellic acid or derivative thereof.
- carrier is used to mean a substance (including a mixture of materials) in which the "boswellia” can be intimately incorporated, typically by solution or dispersion. It is not essential that the "boswellia” be completely dissolved or dispersed in the carrier provided the materials form a mixture that can form a composition that is stable over an extended period of time, typically of at least 3 months.
- flavour ingredient is used to mean a material having a flavour that is generally regarded as pleasant or at least inoffensive by consumers.
- the present invention is based on the su ⁇ rising discovery that certain flavour ingredients, particularly flavour ingredients known or suitable for use in oral care compositions and products (referred to herein as “oral care flavour ingredients”) function as good carriers for the "boswellia", so enabling the "boswellia” to be readily incorporated into oral care compositions or products without the need for excessive amounts of surfactant in the oral care compositions or products to solubilise or disperse the "boswellia", or the need for other solvents. Further, the dissolution or dispersion of the "boswellia" in the carrier comprising at least one flavour ingredient can enable the preparation of clear oral care compositions or products which are preferably free of particulate matter or precipitated "boswellia” .
- Boswellia Extract or Boswellic Acids or Derivatives thereof (“boswellia")
- compositions of the present invention suitably comprise a safe and effective amount, preferably from 1 % to 50% , more preferably from 3 % to 40% and even more preferably from 5 % to 30% by weight of the composition of at least one extract of a Boswellia plant, or at least one boswellic acid or derivative thereof.
- Suitable extracts for use herein may be derived from the following Boswellia plants including Boswellia Carterii, Boswellia Frereana, Boswellia Bhau-dajaina, Boswellia Serrata and Boswellia Thurifera.
- the preferred plants from which extracts are derived are Boswellia Serrata.
- the extracts derived from Boswellia plants can comprise gums, oleo-gums, resins, essential oils and residues, or mixtures thereof.
- Preferred extracts for use herein are gums.
- Boswellia gum extract useful herein comprises a mixture of active triterpenoid compounds more commonly known as boswellic acids. All boswellic acids have a pentacyclic structure based on 12-ursen-24-oic acid with differing substituents . Many individual boswellic acid compounds have been isolated from a Boswellia extract including ⁇ - and ⁇ -boswellic acids and derivatives thereof. Of these, ⁇ -boswellic acid and derivatives thereof are thought to be the active components.
- a typical extract comprising Boswellia Serrata gum resin will comprise greater than 50% by weight boswellic acids and often more than 60% by weight boswellic acids. The extracts may also undergo further purification to yield greater than 90% by weight boswellic acids.
- a typical extract of a Boswellia plant suitable for use herein comprises a mixture of boswellic acids comprising at least one of 3a-hydroxyurs-12-ene-24-oic acid, 3a- acetoxyurs-12-ene-24-oic acid, 3a-hydroxyurs-12-ene-l l-keto-24-oic acid and 3a- hydroxyurs-9, 12-dien-24-oic acid.
- Boswellia extracts suitable for use herein are commercially available for example from Quest International, Kent, UK.
- compositions of the invention typically comprise from 50% to 99% , preferably from 60% to 97% , and more preferably from 70% to 95 % by weight of the composition of a carrier.
- the flavour ingredient preferably comprises an oral care flavour ingredient. As discussed above these are found to have good carrier properties, and clearly such materials are also well suited to use in compositions and products for use in the oral cavity.
- Suitable oral care flavour ingredients include peppermint oil, spearmint oil, orange oil, lemon oil, L-menthol, menthone, menthyl acetate, and L-carvone, or mixtures thereof.
- the at least one flavour ingredient, preferably oral care flavour ingredient, used as a carrier in the compositions of the invention should desirably be capable of dissolving the at least one Boswellia extract, or boswellic acid or derivative thereof.
- compositions of the invention may optionally additionally comprise other ingredients such as excipients conventionally added to compositions suitable for use in the oral cavity, eg a surfactant, starch, sucrose, a polyol, an abrasive material, a humectant, a binder, a thickener, an antibacterial agent, an anti-inflammatory agent, an anticaries agent, a vitamin, a potassium salt, an enzyme or an anti-calculus agent, and mixtures thereof.
- compositions of the present invention may be used in wide range of products, by which is meant consumer products i.e. for use by a consumer or end-user, particularly, but not exclusively, for use in the oral cavity.
- Suitable products for oral use include a mouthwash, a toothpaste, a gel, a cream, a tooth powder, a gargle, a lozenge which will dissolve in the mouth, chewing gum or dental floss.
- the present invention provides a product for use in the oral cavity, comprising a composition in accordance with the invention.
- the mouthwash may comprise an aqueous suspension of a composition comprising a Boswellia extract, or boswellic acid or derivative thereof dissolved in a flavouring ingredient wherein said composition may be made compatible with water by the use of a compatibilising solvent such as ethanol.
- the product could be a multicomponent mouthwash comprising a plurality of solutions containing a composition of the invention and/or additional desirable mouthwash components. These individual aqueous solutions or suspensions would preferably be mixed together before use by the user.
- compositions or products herein may comprise conventional orally, eg dentally acceptable ingredients normally present in compositions or products for oral use.
- ingredients include active materials such as triclosan, chlorhexidine, copper, stannous and zinc salts, such as copper sulphate, stannous pyrophosphate and zinc citrate, sanguinarine extract, metronidazole, cetylpyridinium chloride, chlorhexidine digluconate, hexetidine, octenidine, alexidine, 2,2'-methylenebis- (4-chloro-6-bromophenol); orally compatible colouring agents such as pigments e.g.
- titanium dioxide or oil soluble colours as are known to be used for aesthetic reasons to produce an attractive coloured product instead of a clear colourless product; starches; sucrose; polyols; abrasive materials such as silicas, aluminas, calcium carbonates, calcium phosphates, hydroxy apatites, calcium pyrophosphates, trimetaphosphates and insoluble hexametaphosphates; humectants such as glycerol, sorbitol, propylene glycol and latitol; binders and thickeners such as sodium carboxymethylcellulose, xanthan gum, gum arabic, polyacrylates and carboxy vinyl polymers; anti-inflammatory agents such as ibuprofen, flurbiprofen, aspirin and indomethacin; anticaries agents such as sodium fluoride, stannous fluoride, amine fluorides, sodium monofluorophosphate, calcium lactate, calcium glycerophosphates, strontium salts
- the toothpaste or gel conveniently may include an anionic surfactant, such as sodium lauryl sulphate, sodium dodecylbenzene sulphonate, sodium mono- and di-octyl phosphate and/or sodium lauroylsarcosinate.
- an anionic surfactant such as sodium lauryl sulphate, sodium dodecylbenzene sulphonate, sodium mono- and di-octyl phosphate and/or sodium lauroylsarcosinate.
- the product may include one or more non-ionic surfactants and/or one or more amphoteric surfactants.
- the product may comprise a mixture of anionic and/or non-ionic and/or amphoteric surfactants.
- Non-ionic surfactants which can be used for this purpose, include, but are not limited to, polyoxyethylene alkyl ethers, polyoxyethylene alkaryl ethers, polyoxyethylene- polyoxypropylene alkyl ethers, polyoxyethylene-polyoxypropylene block copolymers, sucrose fatty acid esters, glycerol fatty acid esters, propylene glycol fatty acid esters, sorbitan fatty acid esters, alkylglycoside fatty acid esters, polyoxyethylene sucrose fatty acid esters, polyoxyethylene glycol fatty acid esters, polyoxyethylene sorbitan fatty acid esters, alkvlglycosides, fatty acid monoethanolamide, polyoxyethylene fatty acid monoethanolamide, polyoxyethylene fatty acid diethanolamide.
- polyoxyethylene castor oils polyoxyethylene hydrogenated castor oils
- polyoxyethylene beeswax derivatives polyoxyethylene beeswax derivatives.
- a suitable example of an amphoteric surfactant which may be useful herein is cocoamidopropyl betaine.
- colouring agents and/or active materials as discussed in the immediately preceding paragraph may also be included.
- compositions suitable for oral care use comprising a composition in accordance with the invention typically comprise from 0.001 % to 5.0% by weight and preferably from 0.05% to 0.5% by weight of the product of at least one extract of a Boswellia plant, or at least one boswellic acid or derivative thereof.
- compositions according to the invention were prepared by mixing ingredients in the amounts listed below. % w/w
- Boswellia Extract 1 [ > 65 % boswellic acids or derivatives] 30.00
- Boswellia Extract 1 [ > 65 % boswellic acids or derivatives] 25.00 Spearmint oil 75.00
- Boswellia Extract 1 [ > 65 % boswellic acids or derivatives] 25.00
- Boswellia Extract 1 [ > 65 % boswellic acids or derivatives] 20.00 L-Carvone 80.00
- Boswellia Extract 1 [ > 75 % boswellic acids or derivatives] 30.00 Peppermint oil 70.00
- Compositions 1 to 7 were prepared by mixing together the Boswellia Extract and flavour ingredient with gentle heating until the Boswellia Extract dissolved to the desired extent.
- compositions according to the invention include:
- composition 8 menthone 3.0 menthyl acetate 5.0
- composition 10 menthone 8.0
- spearmint oil 54.5 orange oil 1.0 menthyl acetate 5.5
- composition 11 lemon oil 0.5 peppermint oil 8.5
- compositions 8 to 11 were prepared according to the method described in Example 1 above, where the Boswellia Extract was added to the combined flavour ingredients and the mixture gently heated until the Boswellia Extract dissolved to the desired extent.
- Comparative mouthwash A using ethanol as a carrier for the Boswellia extract
- mouthwash B using a mixture of flavour ingredients as a carrier for the Boswellia extract in accordance with the invention
- Mouthwash A was prepared by combining the flavour ingredients, to which polysorbate 20 was added. This mixture was then added to water.
- the Boswellia Serrata Extract was added to ethanol with stirring and mixed until dissolved. Following dissolution of the Boswellia Extract in the ethanol, the mixture was added to the water/flavour/poly sorbate 20 mix. The resulting mouthwash was slightly turbid and had an insoluble precipitate.
- Mouthwash B in accordance with the invention was prepared by mixing the flavour ingredients together with the Boswellia Serrata Extract. To this mixture was added polysorbate 20.
- the resulting mouthwash was crystal clear with no precipitate.
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
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Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU39817/00A AU3981700A (en) | 1999-04-16 | 2000-04-12 | Compositions containing boswellia extracts |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9908593.8 | 1999-04-16 | ||
GBGB9908593.8A GB9908593D0 (en) | 1999-04-16 | 1999-04-16 | Dental compositions containing boswellia extracts |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2000062751A2 true WO2000062751A2 (fr) | 2000-10-26 |
WO2000062751A3 WO2000062751A3 (fr) | 2001-01-18 |
Family
ID=10851567
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2000/001396 WO2000062751A2 (fr) | 1999-04-16 | 2000-04-12 | Compositions contenant des extraits de boswellia |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU3981700A (fr) |
GB (1) | GB9908593D0 (fr) |
WO (1) | WO2000062751A2 (fr) |
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003105794A1 (fr) * | 2002-06-18 | 2003-12-24 | Takasago International Corporation | Composition antibacterienne de parfum et de fragrance et composition de parfum et de fragrance inhibant l'halitose et composition de soins buccaux les contenant |
WO2004082643A2 (fr) * | 2003-03-20 | 2004-09-30 | Shiseido International France | Composition cosmetique |
WO2005123037A1 (fr) * | 2004-06-22 | 2005-12-29 | Birken Gmbh | Agent oleogelifiant contenant du triterpene, oleogel contenant du triterpene et procede de fabrication d'un agent oleogelifiant contenant du triterpene |
WO2006054921A3 (fr) * | 2004-11-16 | 2006-08-17 | Koy Tekhn I Ekopitaniya Diod O | Extrait et produit possedant une activite anti-inflammatoire et procede de sa fabrication |
WO2008150197A1 (fr) * | 2007-06-07 | 2008-12-11 | Otkrytoe Aktsionernoe Obschestvo Zavod Ekologicheskoy Tekhniki I Ekopitaniya 'diod' | Additif biologiquement actif servant à la prévention et au traitement de l'asthme et de maladies des voies respiratoires supérieures et procédé de production correspondant |
EP1774955A3 (fr) * | 2005-10-17 | 2010-02-17 | Henkel AG & Co. KGaA | Collutoire prêt-à-l'emploi |
US8003142B2 (en) | 2005-12-23 | 2011-08-23 | Otkrytoe Aktsionernoe Obschestvo Zavod Ekologischeeskoy Tekhniki I Ekopitaniya “DIOD” | Therapeutic and cosmetic balsam |
US8192768B2 (en) | 2007-04-03 | 2012-06-05 | Laila Impex | Synergistic anti-inflammatory and antioxidant dietary supplement compositions |
WO2014003741A1 (fr) * | 2012-06-26 | 2014-01-03 | Young Living Essential Oils, Lc. | Gomme à mâcher à l'oliban |
US9468590B2 (en) | 2009-12-10 | 2016-10-18 | Neubourg Skin Care Gmbh & Co. Kg | Emulsifier-free, polymer-stabilized foam formulations |
KR101752635B1 (ko) * | 2010-02-15 | 2017-07-03 | 라일라 뉴트라슈티칼스 | 신규의 보스웰리아 저-극성 고무 수지 추출물 및 이의 상승적인 조성물 |
WO2018211420A1 (fr) * | 2017-05-15 | 2018-11-22 | Firmenich Sa | Compositions comprenant des huiles essentielles |
US10463590B1 (en) * | 2018-12-20 | 2019-11-05 | Matthias W. Rath | Antiplaque and dental health oral formulation |
US10610474B1 (en) * | 2018-12-20 | 2020-04-07 | Matthias W. Rath | Antibacterial and antifungal dental health formulation |
US11083733B2 (en) | 2018-01-04 | 2021-08-10 | Amryt Research Limited | Betulin-containing birch bark extracts and their formulation |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0552657A1 (fr) * | 1992-01-24 | 1993-07-28 | AMMON, Hermann P.T. | Utilisation de l'acide boswellique pur |
WO1997002040A1 (fr) * | 1995-07-03 | 1997-01-23 | Bevilacqua, Maria | Produit pharmaceutique a base de terpene |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4299374B2 (ja) * | 1996-10-08 | 2009-07-22 | 高砂香料工業株式会社 | 細胞賦活剤及びその応用 |
-
1999
- 1999-04-16 GB GBGB9908593.8A patent/GB9908593D0/en not_active Ceased
-
2000
- 2000-04-12 AU AU39817/00A patent/AU3981700A/en not_active Abandoned
- 2000-04-12 WO PCT/GB2000/001396 patent/WO2000062751A2/fr active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0552657A1 (fr) * | 1992-01-24 | 1993-07-28 | AMMON, Hermann P.T. | Utilisation de l'acide boswellique pur |
WO1997002040A1 (fr) * | 1995-07-03 | 1997-01-23 | Bevilacqua, Maria | Produit pharmaceutique a base de terpene |
Non-Patent Citations (2)
Title |
---|
B CLEMENT ET AL.: "Huiles essentielles et dérivés végétaux en hygiène bucco-dentaire" PARFUMS, COSMETIQUES, AROMES, vol. 83, October 1988 (1988-10) - November 1988 (1988-11), pages 87-94, XP000003315 Paris * |
DATABASE WPI Week 199828 Derwent Publications Ltd., London, GB; AN 1998-316696 XP002144113 & JP 10 114671 A (TAKASAGO PERFUMERY CO) cited in the application * |
Cited By (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003105794A1 (fr) * | 2002-06-18 | 2003-12-24 | Takasago International Corporation | Composition antibacterienne de parfum et de fragrance et composition de parfum et de fragrance inhibant l'halitose et composition de soins buccaux les contenant |
CN100508937C (zh) * | 2002-06-18 | 2009-07-08 | 高砂香料工业株式会社 | 抗菌调味剂和香料组合物、抑制口臭的调味剂和香料组合物以及含有所述组合物的口腔护理组合物 |
WO2004082643A2 (fr) * | 2003-03-20 | 2004-09-30 | Shiseido International France | Composition cosmetique |
WO2004082643A3 (fr) * | 2003-03-20 | 2007-06-14 | Shiseido Int France | Composition cosmetique |
WO2005123037A1 (fr) * | 2004-06-22 | 2005-12-29 | Birken Gmbh | Agent oleogelifiant contenant du triterpene, oleogel contenant du triterpene et procede de fabrication d'un agent oleogelifiant contenant du triterpene |
US8536380B2 (en) | 2004-06-22 | 2013-09-17 | Birken Gmbh | Triterpene-containing oleogel-forming agent, triterpene-containing oleogel and method for producing a triterpene-containing oleogel |
WO2006054921A3 (fr) * | 2004-11-16 | 2006-08-17 | Koy Tekhn I Ekopitaniya Diod O | Extrait et produit possedant une activite anti-inflammatoire et procede de sa fabrication |
JP2008520659A (ja) * | 2004-11-16 | 2008-06-19 | オクトリウイトイエ アクチオネルノイエ オブチェストーヴォ ザヴォート エコロギシェスコイ テクニーキ イー エコピタニーヤ ”ディオド” | 抗炎症性エクストラクトおよび薬剤ならびにその製造方法 |
US8092845B2 (en) | 2004-11-16 | 2012-01-10 | Otkrytoe Aktsionernoe Obschestvo Zavod Ekologicheskoy Tekhniki I Ekopitaniya “Diod” | Anti-inflammatory extract and agent and method for the production thereof |
EP1774955A3 (fr) * | 2005-10-17 | 2010-02-17 | Henkel AG & Co. KGaA | Collutoire prêt-à-l'emploi |
US8003142B2 (en) | 2005-12-23 | 2011-08-23 | Otkrytoe Aktsionernoe Obschestvo Zavod Ekologischeeskoy Tekhniki I Ekopitaniya “DIOD” | Therapeutic and cosmetic balsam |
US8192768B2 (en) | 2007-04-03 | 2012-06-05 | Laila Impex | Synergistic anti-inflammatory and antioxidant dietary supplement compositions |
US8420132B2 (en) | 2007-04-03 | 2013-04-16 | Laila Impex | Synergistic anti-inflammatory and antioxidant dietary supplement compositions |
WO2008150197A1 (fr) * | 2007-06-07 | 2008-12-11 | Otkrytoe Aktsionernoe Obschestvo Zavod Ekologicheskoy Tekhniki I Ekopitaniya 'diod' | Additif biologiquement actif servant à la prévention et au traitement de l'asthme et de maladies des voies respiratoires supérieures et procédé de production correspondant |
US9468590B2 (en) | 2009-12-10 | 2016-10-18 | Neubourg Skin Care Gmbh & Co. Kg | Emulsifier-free, polymer-stabilized foam formulations |
KR101752635B1 (ko) * | 2010-02-15 | 2017-07-03 | 라일라 뉴트라슈티칼스 | 신규의 보스웰리아 저-극성 고무 수지 추출물 및 이의 상승적인 조성물 |
WO2014003741A1 (fr) * | 2012-06-26 | 2014-01-03 | Young Living Essential Oils, Lc. | Gomme à mâcher à l'oliban |
WO2018211420A1 (fr) * | 2017-05-15 | 2018-11-22 | Firmenich Sa | Compositions comprenant des huiles essentielles |
CN110621287A (zh) * | 2017-05-15 | 2019-12-27 | 弗门尼舍有限公司 | 包含精油的组合物 |
US11083733B2 (en) | 2018-01-04 | 2021-08-10 | Amryt Research Limited | Betulin-containing birch bark extracts and their formulation |
US11266660B2 (en) | 2018-01-04 | 2022-03-08 | Amryt Research Limited | Betulin-containing birch bark extracts and their formulation |
US11826374B2 (en) | 2018-01-04 | 2023-11-28 | Amryt Research Limited | Betulin-containing birch bark extracts and their formulation |
US10463590B1 (en) * | 2018-12-20 | 2019-11-05 | Matthias W. Rath | Antiplaque and dental health oral formulation |
US10610474B1 (en) * | 2018-12-20 | 2020-04-07 | Matthias W. Rath | Antibacterial and antifungal dental health formulation |
Also Published As
Publication number | Publication date |
---|---|
AU3981700A (en) | 2000-11-02 |
GB9908593D0 (en) | 1999-06-09 |
WO2000062751A3 (fr) | 2001-01-18 |
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