WO2000050451A3 - An der entwicklung des nervensystems beteiligtes protein (tp) - Google Patents

An der entwicklung des nervensystems beteiligtes protein (tp) Download PDF

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Publication number
WO2000050451A3
WO2000050451A3 PCT/DE2000/000583 DE0000583W WO0050451A3 WO 2000050451 A3 WO2000050451 A3 WO 2000050451A3 DE 0000583 W DE0000583 W DE 0000583W WO 0050451 A3 WO0050451 A3 WO 0050451A3
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WO
WIPO (PCT)
Prior art keywords
proteins
development
nervous system
protein
involved
Prior art date
Application number
PCT/DE2000/000583
Other languages
English (en)
French (fr)
Other versions
WO2000050451A2 (de
Inventor
Annemarie Poustka
Johannes Coy
Original Assignee
Deutsches Krebsforsch
Annemarie Poustka
Johannes Coy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deutsches Krebsforsch, Annemarie Poustka, Johannes Coy filed Critical Deutsches Krebsforsch
Priority to EP00916770A priority Critical patent/EP1165607A2/de
Priority to AU38018/00A priority patent/AU3801800A/en
Publication of WO2000050451A2 publication Critical patent/WO2000050451A2/de
Publication of WO2000050451A3 publication Critical patent/WO2000050451A3/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Beschrieben werden ein Protein (TP) und dazu verwandte Proteine, die an der Entwicklung des Nervensystems, insbesondere des ZNS, beteiligt sind und gewebe- und entwicklungsspezifisch exprimiert werden, sowie diese Proteine codierende DNA-Sequenzen. Beschrieben werden ferner gegen diese Proteine gerichtete Antikörper oder Fragmente davon, sowie gegen die Expression dieser Proteine gerichtete Antisense-RNA bzw. Ribozyme. Schliesslich werden Arzneimittel und Diagnoseverfahren beschrieben, bei denen die vorstehenden Verbindungen zur Anwendung kommen. Ausserdem wird ein nicht-menschliches Säugetier beschrieben, dessen für TP codierendes Gen verändert ist.
PCT/DE2000/000583 1999-02-26 2000-02-28 An der entwicklung des nervensystems beteiligtes protein (tp) WO2000050451A2 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP00916770A EP1165607A2 (de) 1999-02-26 2000-02-28 An der entwicklung des nervensystems beteiligtes protein (tp)
AU38018/00A AU3801800A (en) 1999-02-26 2000-02-28 Protein (tp) that is involved in the development of the nervous system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19908423A DE19908423A1 (de) 1999-02-26 1999-02-26 An der Entwicklung des ZNS beteiligtes Protein (TP)
DE19908423.8 1999-02-26

Publications (2)

Publication Number Publication Date
WO2000050451A2 WO2000050451A2 (de) 2000-08-31
WO2000050451A3 true WO2000050451A3 (de) 2001-08-02

Family

ID=7899009

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2000/000583 WO2000050451A2 (de) 1999-02-26 2000-02-28 An der entwicklung des nervensystems beteiligtes protein (tp)

Country Status (4)

Country Link
EP (1) EP1165607A2 (de)
AU (1) AU3801800A (de)
DE (1) DE19908423A1 (de)
WO (1) WO2000050451A2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10042609A1 (de) * 2000-08-30 2002-03-28 Deutsches Krebsforsch Verwendung von T-Proteinen zur differentiellen Charakterisierung und Therapie von Verletzungen und Tumoren des Nervensystems
WO2003085134A2 (en) * 2002-04-05 2003-10-16 The University Of Tokyo Methods of diagnosing and treating colorectal cancer
EP3816934A1 (de) 2019-11-04 2021-05-05 Nathan Vinçon Verfahren und computerisiertes system zur markierung eines bildes von zellen eines patienten

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993016178A2 (en) * 1992-02-12 1993-08-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Sequences characteristic of human gene transcription product
WO1995012677A2 (en) * 1993-11-04 1995-05-11 Innogenetics N.V. Immunodominant human t-cell epitopes of hepatitis c virus
EP0679716A1 (de) * 1993-11-12 1995-11-02 Kenichi Matsubara Genetische Signaturen
WO1996038555A2 (en) * 1995-05-31 1996-12-05 Thierry Bogaert Unc-53 from c. elegans and its uses in testing compounds involved in the control fo cell behaviour and pharmaceutical compositions
WO1998007748A2 (en) * 1996-08-22 1998-02-26 Vlaams Interuniversitair Instituut Voor Biotechnologie Plag gene family and tumorigenesis
WO1998024810A2 (en) * 1996-12-04 1998-06-11 Janssen Pharmaceutica N.V. Vertebrate homologues of unc-53 protein of c. elegans
WO1998046747A2 (en) * 1997-04-11 1998-10-22 Whitehead Institute For Biomedical Research Genes in the non-recombining region of the y chromosome
WO1999063080A1 (en) * 1998-06-03 1999-12-09 Janssen Pharmaceutica N.V. HUMAN HOMOLOGUE OF UNC-53 PROTEIN OF $i(C. ELEGANS)

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993016178A2 (en) * 1992-02-12 1993-08-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Sequences characteristic of human gene transcription product
WO1995012677A2 (en) * 1993-11-04 1995-05-11 Innogenetics N.V. Immunodominant human t-cell epitopes of hepatitis c virus
EP0679716A1 (de) * 1993-11-12 1995-11-02 Kenichi Matsubara Genetische Signaturen
WO1996038555A2 (en) * 1995-05-31 1996-12-05 Thierry Bogaert Unc-53 from c. elegans and its uses in testing compounds involved in the control fo cell behaviour and pharmaceutical compositions
WO1998007748A2 (en) * 1996-08-22 1998-02-26 Vlaams Interuniversitair Instituut Voor Biotechnologie Plag gene family and tumorigenesis
WO1998024810A2 (en) * 1996-12-04 1998-06-11 Janssen Pharmaceutica N.V. Vertebrate homologues of unc-53 protein of c. elegans
WO1998046747A2 (en) * 1997-04-11 1998-10-22 Whitehead Institute For Biomedical Research Genes in the non-recombining region of the y chromosome
WO1999063080A1 (en) * 1998-06-03 1999-12-09 Janssen Pharmaceutica N.V. HUMAN HOMOLOGUE OF UNC-53 PROTEIN OF $i(C. ELEGANS)

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
BIRREN B. ET AL.: "Homo sapiens chromosome 11, clone RP11-808N1, map11, WORKING DRAFT SEQUENCE, 18 unordered pieces", EMBL DATABASE ENRTY AC023950; ACCESSION NO. AC023950, 21 February 2000 (2000-02-21), XP002157899 *
HILLIER L. ET AL.: "Generation and analysis of 280,000 human expressed sequence tags", GENOME RESEARCH, vol. 6, no. 9, September 1996 (1996-09-01), pages 807 - 828, XP002140684, ISSN: 1054-9803 *
HILLIER L. ET AL.: "ye32e03.r1 Stratagene lung (#937210) Homo sapiens cDNA clone IMAGE:119452 5', mRNA sequence", EMBL DATABASE ENTRY HS91170; ACCESSION NO. T94911, 14 April 1995 (1995-04-14), XP002157904 *
HILLIER L. ET AL.: "z141a05.r1 Soares_pregnant_uterus_NbHPU Homo sapiens cDNA clone IMAGE:504464 5' mRNA sequence", EMBL DATABASE ENTRY HSAA50056; ACCESSION NO. AA150056, 15 December 1996 (1996-12-15), XP002157903 *
MARRA M. ET AL.: "The WashU-HHMI Mouse EST Project; mu51c03.r1 Soares mouse lymph node NbMLN Mus musculus cDNA clone IMAGE:642916 5', mRNA sequence", EMBL DATABASE ENTRY MMAA85349; AA185349, 21 February 1997 (1997-02-21), XP002157898 *
MARRA M. ET AL.: "The WashU-HHMI Mouse EST Project; mw75e12.r1 Soares mouse NML Mus musculus cDNA clone IMAGE:676558 5', mRNA sequence", EMBL DATABASE ENTRY MMAA81408; ACCESSION NO. AA208994, 1 February 1997 (1997-02-01), XP002157902 *
MARRA M. ET AL.: "The WashU-HHMI Mouse EST Project; uj15c04.y1 Sugano mouse kidney mkia Mus musculus cDNA clone IMAGE:1908102 5' similar to SW:GELA_DICDI P13466 GELATION FACTOR; mRNA sequence.", EMBL DATABASE ENTRY AI226752; ACCESSION NO. AI226752, 31 October 1998 (1998-10-31), XP002157901 *
MARRA M. ET AL.: "The WashU-HHMI Mouse EST Project; vd71a09.r1 Beddington mouse embryonic region Mus musculus cDNA clone IMAGE:806008 5', mRNA sequence", EMBL DATABASE ENTRY MMAA99795; AA399795, 29 April 1997 (1997-04-29), XP002157897 *
MUZNY D.M. ET AL.: "Homo sapiens chromosome 12 clone RP3-454B23, WORKING DRAFT SEQUENCE, 8 unordered pieces", EMBL DATABASE ENTRY AC005845; ACCESSION NO. AC005845, 23 October 1998 (1998-10-23), XP002157900 *
NCI-CGAP: "National Cancer Institute, Cancer Genome Anatomy Project (CGAP), Tumor Gene Index http://www.ncbi.nlm.nih.gov/ncicgap; qb18e07.x1 Soares_pregnant_uterus_NbHPU Homo sapiens cDNA clone IMAGE:1696644 3',mRNA sequence", EMBL DATABASE ENTRY AI090184; ACCESSION NO. AI090184, 18 August 1998 (1998-08-18), XP002149581 *
VERHASSELT P.K. ET AL.: "Nucleotide sequence of BAC 585E09, containing the putative promoter region and 5' end of the human Steerin-1 gene which is homologous to the C. elegans UNC53 gene; Homo sapiens partial steerin-1 gene", EMBL DATABASE ENTRY HSA251973; ACCESSION NO. AJ251973, 14 January 2000 (2000-01-14), XP002157896 *
WOESSNER J. ET AL.: "Full Clone Sequencing of the Longest Available Member from Each Unigene Cluster", EMBL DATABASE ENTRY AF086348; ACCESSION NO. AF086348, 3 September 1998 (1998-09-03), XP002157895 *

Also Published As

Publication number Publication date
WO2000050451A2 (de) 2000-08-31
AU3801800A (en) 2000-09-14
EP1165607A2 (de) 2002-01-02
DE19908423A1 (de) 2000-08-31

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