WO2000049043A3 - Human lipid-associated proteins - Google Patents

Human lipid-associated proteins Download PDF

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Publication number
WO2000049043A3
WO2000049043A3 PCT/US2000/004160 US0004160W WO0049043A3 WO 2000049043 A3 WO2000049043 A3 WO 2000049043A3 US 0004160 W US0004160 W US 0004160W WO 0049043 A3 WO0049043 A3 WO 0049043A3
Authority
WO
WIPO (PCT)
Prior art keywords
associated proteins
lipap
human lipid
provides
lipid
Prior art date
Application number
PCT/US2000/004160
Other languages
French (fr)
Other versions
WO2000049043A2 (en
Inventor
Y Tom Tang
Jennifer L Hillman
Henry Yue
Yalda Azimzai
Mariah R Baughn
Bao Tran
Original Assignee
Incyte Pharma Inc
Y Tom Tang
Jennifer L Hillman
Henry Yue
Yalda Azimzai
Mariah R Baughn
Bao Tran
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Pharma Inc, Y Tom Tang, Jennifer L Hillman, Henry Yue, Yalda Azimzai, Mariah R Baughn, Bao Tran filed Critical Incyte Pharma Inc
Priority to CA002362300A priority Critical patent/CA2362300A1/en
Priority to EP00908718A priority patent/EP1153035A2/en
Priority to JP2000599780A priority patent/JP2002541772A/en
Priority to AU30012/00A priority patent/AU3001200A/en
Publication of WO2000049043A2 publication Critical patent/WO2000049043A2/en
Publication of WO2000049043A3 publication Critical patent/WO2000049043A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The invention provides human lipid-associated proteins (LIPAP) and polynucleotides which identify and encode LIPAP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of LIPAP.
PCT/US2000/004160 1999-02-19 2000-02-18 Human lipid-associated proteins WO2000049043A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002362300A CA2362300A1 (en) 1999-02-19 2000-02-18 Human lipid-associated proteins
EP00908718A EP1153035A2 (en) 1999-02-19 2000-02-18 Human lipid-associated proteins
JP2000599780A JP2002541772A (en) 1999-02-19 2000-02-18 Human lipid-related protein
AU30012/00A AU3001200A (en) 1999-02-19 2000-02-18 Human lipid-associated proteins

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US12070399P 1999-02-19 1999-02-19
US60/120,703 1999-02-19
US14276299P 1999-07-08 1999-07-08
US60/142,762 1999-07-08

Publications (2)

Publication Number Publication Date
WO2000049043A2 WO2000049043A2 (en) 2000-08-24
WO2000049043A3 true WO2000049043A3 (en) 2001-02-01

Family

ID=26818670

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/004160 WO2000049043A2 (en) 1999-02-19 2000-02-18 Human lipid-associated proteins

Country Status (5)

Country Link
EP (1) EP1153035A2 (en)
JP (1) JP2002541772A (en)
AU (1) AU3001200A (en)
CA (1) CA2362300A1 (en)
WO (1) WO2000049043A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7972802B2 (en) 2005-10-31 2011-07-05 University Of Washington Lipoprotein-associated markers for cardiovascular disease
US8241861B1 (en) 2008-07-08 2012-08-14 Insilicos, Llc Methods and compositions for diagnosis or prognosis of cardiovascular disease

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5472858A (en) * 1991-06-04 1995-12-05 Wisconsin Alumni Research Foundation Production of recombinant proteins in insect larvae
CA2200794A1 (en) * 1997-03-24 1998-09-24 The Governing Council Of The University Of Toronto Gene and protein related to alzheimer's disease
WO2000009688A1 (en) * 1998-08-12 2000-02-24 Kazusa Dna Research Institute Foundation Novel gene and protein osbh encoded thereby

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5472858A (en) * 1991-06-04 1995-12-05 Wisconsin Alumni Research Foundation Production of recombinant proteins in insect larvae
CA2200794A1 (en) * 1997-03-24 1998-09-24 The Governing Council Of The University Of Toronto Gene and protein related to alzheimer's disease
WO2000009688A1 (en) * 1998-08-12 2000-02-24 Kazusa Dna Research Institute Foundation Novel gene and protein osbh encoded thereby

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Week 200019, Derwent World Patents Index; AN 2000-224333, XP002144844 *
KOTANI ET AL.: "Homo spiens mRNA for KIAA0772 protein, complete cds.", EMBL SEQUENCE DATABASE, 17 November 1998 (1998-11-17), HEIDELBERG DE, XP002144842 *
KOTANI ET AL.: "KIAA0772 protein", EMBL SEQUENCE DATABASE, 1 November 1999 (1999-11-01), HEIDELBERG DE, XP002144843 *
NAGASE ET AL: "PREDICTION OF THE CODING SEQUENCES OF UNIDENTIFIED HUMAN GENES. XI.THE COMPLETE SEQUENCES OF 100 NEW CDNA CLONES FROM BRAIN WHICH CODEFOR LARGE PROTEINS IN VITRO", DNA RESEARCH, vol. 5, 1998, pages 277 - 286, XP002926060, ISSN: 1340-2838 *

Also Published As

Publication number Publication date
JP2002541772A (en) 2002-12-10
CA2362300A1 (en) 2000-08-24
AU3001200A (en) 2000-09-04
WO2000049043A2 (en) 2000-08-24
EP1153035A2 (en) 2001-11-14

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