WO2000078953A3 - Human transport proteins - Google Patents

Human transport proteins Download PDF

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Publication number
WO2000078953A3
WO2000078953A3 PCT/US2000/016668 US0016668W WO0078953A3 WO 2000078953 A3 WO2000078953 A3 WO 2000078953A3 US 0016668 W US0016668 W US 0016668W WO 0078953 A3 WO0078953 A3 WO 0078953A3
Authority
WO
WIPO (PCT)
Prior art keywords
transport proteins
tppt
human transport
provides
expression
Prior art date
Application number
PCT/US2000/016668
Other languages
French (fr)
Other versions
WO2000078953A2 (en
Inventor
Preeti Lal
Junming Yang
Henry Yue
Jennifer L Hillman
Y Tom Tang
Olga Bandman
Neil Burford
Mariah R Baughn
Yalda Azimzai
Dyung Aina M Lu
Janice Au-Young
Chandra Patterson
Original Assignee
Incyte Genomics Inc
Preeti Lal
Junming Yang
Henry Yue
Jennifer L Hillman
Y Tom Tang
Olga Bandman
Neil Burford
Mariah R Baughn
Yalda Azimzai
Dyung Aina M Lu
Au Young Janice
Chandra Patterson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Genomics Inc, Preeti Lal, Junming Yang, Henry Yue, Jennifer L Hillman, Y Tom Tang, Olga Bandman, Neil Burford, Mariah R Baughn, Yalda Azimzai, Dyung Aina M Lu, Au Young Janice, Chandra Patterson filed Critical Incyte Genomics Inc
Priority to CA002375493A priority Critical patent/CA2375493A1/en
Priority to JP2001505695A priority patent/JP2003529325A/en
Priority to AU57442/00A priority patent/AU5744200A/en
Priority to EP00942880A priority patent/EP1190051A2/en
Publication of WO2000078953A2 publication Critical patent/WO2000078953A2/en
Publication of WO2000078953A3 publication Critical patent/WO2000078953A3/en

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    • C—CHEMISTRY; METALLURGY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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Abstract

The invention provides human transport proteins (TPPT) and polynucleotides which identify and encode TPPT. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of TPPT.
PCT/US2000/016668 1999-06-17 2000-06-16 Human transport proteins WO2000078953A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002375493A CA2375493A1 (en) 1999-06-17 2000-06-16 Human transport proteins
JP2001505695A JP2003529325A (en) 1999-06-17 2000-06-16 Human transport protein
AU57442/00A AU5744200A (en) 1999-06-17 2000-06-16 Human transport proteins
EP00942880A EP1190051A2 (en) 1999-06-17 2000-06-16 Human transport proteins

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US13992399P 1999-06-17 1999-06-17
US60/139,923 1999-06-17
US14817799P 1999-08-10 1999-08-10
US60/148,177 1999-08-10
US14935799P 1999-08-18 1999-08-18
US60/149,357 1999-08-18
US16228799P 1999-10-28 1999-10-28
US60/162,287 1999-10-28

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Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6869592B1 (en) 1998-08-04 2005-03-22 Diadexus, Inc. Method and antibody for imaging lung cancer
WO2001042469A1 (en) * 1999-12-10 2001-06-14 Lexicon Genetics Incorporated Novel human transporter protein and polynucleotides encoding the same
US20020173455A1 (en) * 2000-02-29 2002-11-21 Curtis Rory A. J. 23927, a novel human ion channel
CA2403809A1 (en) * 2000-03-22 2001-09-27 Curagen Corporation Angiogenesis - associated proteins, and nucleic acids encoding the same
AU2001281943A1 (en) * 2000-07-03 2002-01-14 Nalan Utku The t-cell protein (tzon7), peptides and antibodies derived therefrom and uses thereof
WO2002010390A2 (en) * 2000-07-31 2002-02-07 Millennium Pharmaceuticals, Inc. 57250, a human sugar transporter family member and uses thereof
US20020156002A1 (en) * 2000-08-22 2002-10-24 Curtis Rory A.J. 32620, a novel human sodium-sugar symporter family member and uses thereof
WO2002081654A2 (en) * 2001-03-27 2002-10-17 Pe Corporation (Ny) Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins, and uses thereof
US7033790B2 (en) 2001-04-03 2006-04-25 Curagen Corporation Proteins and nucleic acids encoding same
WO2002103015A2 (en) * 2001-06-14 2002-12-27 Active Pass Pharmaceuticals, Inc. Abca10 transporter
EP1513951A4 (en) * 2002-05-16 2005-12-28 Avalon Pharmaceuticals Cancer-linked gene as target for chemotherapy
DK1939288T3 (en) 2005-09-29 2013-03-11 Eisai R&D Man Co Ltd T cell adhesion molecule and antibody directed against the molecule
WO2008113789A1 (en) 2007-03-19 2008-09-25 Basf Se Method for coating water-absorbent polymer particles
JP5759664B2 (en) * 2008-08-29 2015-08-05 花王株式会社 CNG channel inhibitor

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999021885A1 (en) * 1997-10-29 1999-05-06 Shanghai Second Medical University A human abc transporter-7 (habc7) gene
WO2000037643A2 (en) * 1998-12-23 2000-06-29 Corixa Corporation Compounds for immunotherapy and diagnosis of colon cancer and methods for their use
WO2000058473A2 (en) * 1999-03-31 2000-10-05 Curagen Corporation Nucleic acids including open reading frames encoding polypeptides; 'orfx'

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999021885A1 (en) * 1997-10-29 1999-05-06 Shanghai Second Medical University A human abc transporter-7 (habc7) gene
WO2000037643A2 (en) * 1998-12-23 2000-06-29 Corixa Corporation Compounds for immunotherapy and diagnosis of colon cancer and methods for their use
WO2000058473A2 (en) * 1999-03-31 2000-10-05 Curagen Corporation Nucleic acids including open reading frames encoding polypeptides; 'orfx'

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE EM_EST E.B.I., Hinxton, U.K.; 28 October 1997 (1997-10-28), HILLIER L ET AL: "af28g03.s1 Soares_total_fetus_Nb2HF8_9w Homo sapiens cDNA clone IMAGE:1033012 3', mRNA sequence", XP002156358 *
DATABASE EM-HUM E.B.I., Hinxton, U.K.; 1 June 1999 (1999-06-01), LAI C-H ET AL: "Homo sapiens CGI-73 protein mRNA, complete cds", XP002156357 *

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