WO2000044900A3 - Nucleic-acid binding proteins - Google Patents

Nucleic-acid binding proteins Download PDF

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Publication number
WO2000044900A3
WO2000044900A3 PCT/US2000/002237 US0002237W WO0044900A3 WO 2000044900 A3 WO2000044900 A3 WO 2000044900A3 US 0002237 W US0002237 W US 0002237W WO 0044900 A3 WO0044900 A3 WO 0044900A3
Authority
WO
WIPO (PCT)
Prior art keywords
binding proteins
acid binding
nucleic
nuabp
provides
Prior art date
Application number
PCT/US2000/002237
Other languages
French (fr)
Other versions
WO2000044900A2 (en
Inventor
Y Tom Tang
Pretti Lal
Jennifer L Hillman
Henry Yue
Yalda Azimzai
Aina M D Lu
Mariah R Baughn
Bao Tran
Leo L Shih
Janice L Au-Young
Original Assignee
Incyte Pharma Inc
Y Tom Tang
Pretti Lal
Jennifer L Hillman
Henry Yue
Yalda Azimzai
Aina M D Lu
Mariah R Baughn
Bao Tran
Leo L Shih
Au Young Janice L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Pharma Inc, Y Tom Tang, Pretti Lal, Jennifer L Hillman, Henry Yue, Yalda Azimzai, Aina M D Lu, Mariah R Baughn, Bao Tran, Leo L Shih, Au Young Janice L filed Critical Incyte Pharma Inc
Priority to AU27434/00A priority Critical patent/AU2743400A/en
Priority to JP2000596142A priority patent/JP2003521231A/en
Priority to CA002359701A priority patent/CA2359701A1/en
Priority to EP00905810A priority patent/EP1144625A2/en
Publication of WO2000044900A2 publication Critical patent/WO2000044900A2/en
Publication of WO2000044900A3 publication Critical patent/WO2000044900A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention provides human nucleic-acid binding proteins (NuABP) and polynucleotides which identify and encode NuABP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of NuABP.
PCT/US2000/002237 1999-01-29 2000-01-28 Nucleic-acid binding proteins WO2000044900A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU27434/00A AU2743400A (en) 1999-01-29 2000-01-28 Nucleic-acid binding proteins
JP2000596142A JP2003521231A (en) 1999-01-29 2000-01-28 Nucleic acid binding protein
CA002359701A CA2359701A1 (en) 1999-01-29 2000-01-28 Nucleic-acid binding proteins
EP00905810A EP1144625A2 (en) 1999-01-29 2000-01-28 Nucleic-acid binding proteins

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11790499P 1999-01-29 1999-01-29
US11790599P 1999-01-29 1999-01-29
US60/117,905 1999-01-29
US60/117,904 1999-01-29

Publications (2)

Publication Number Publication Date
WO2000044900A2 WO2000044900A2 (en) 2000-08-03
WO2000044900A3 true WO2000044900A3 (en) 2000-11-30

Family

ID=26815777

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/002237 WO2000044900A2 (en) 1999-01-29 2000-01-28 Nucleic-acid binding proteins

Country Status (5)

Country Link
EP (1) EP1144625A2 (en)
JP (1) JP2003521231A (en)
AU (1) AU2743400A (en)
CA (1) CA2359701A1 (en)
WO (1) WO2000044900A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020151696A1 (en) * 2000-11-29 2002-10-17 Millennium Pharmaceuticals, Inc. 84242,8035, 55304, 52999, and 21999, novel human proteins and methods of use thereof
AU2002243750A1 (en) * 2001-01-30 2002-08-12 Regeneron Pharmaceuticals, Inc. Novel nucleic acid and polypeptide molecules
WO2002072612A2 (en) * 2001-03-12 2002-09-19 Praecis Pharmaceuticals Incorporated Peptidic modulators of the androgen receptor
WO2003000279A1 (en) * 2001-06-21 2003-01-03 The Brigham And Women's Hospital, Inc. GEMININ AND orc3N INHIBIT REPLICATION OF HERPESVIRUSES, PAPILLOMAVIRUSES, AND POLYOMAVIRUSES
CA2399569A1 (en) 2001-09-25 2003-03-25 Yusuke Nakamura Diagnostic markers and drug targets for treatment of cancer
JP4353798B2 (en) * 2001-09-25 2009-10-28 オンコセラピー・サイエンス株式会社 Genes and proteins associated with hepatocellular carcinoma
DE10212397A1 (en) 2002-03-20 2003-10-16 Universitaetsklinikum Freiburg Repressor of skeletal muscle differentiation, nucleic acid coding for it and its use in diagnostics and therapy
WO2004072269A2 (en) * 2003-02-12 2004-08-26 Mayo Foundation For Medical Education And Research Bex4 nucleic acids, polypeptides, and method of using
CN102172408A (en) * 2003-02-28 2011-09-07 肿瘤疗法科学股份有限公司 Compositions and methods of inhibiting cell growth
TWI350373B (en) 2004-01-23 2011-10-11 Oncotherapy Science Inc Methods of detecting methyl transferase activity and methods of screening formethyl transferase activity modulators
EP1866436A1 (en) 2005-02-28 2007-12-19 Oncotherapy Science, Inc. Breast cancer related gene znfn3a1
TW200741009A (en) 2005-07-01 2007-11-01 Oncotherapy Science Inc Methods of modulating SMYD3 for treatment of cancer
TW200909587A (en) 2007-06-14 2009-03-01 Oncotherapy Science Inc Methods of identifying agents that modulate methylation of VEGFR1 by SMYD3

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5206152A (en) * 1988-04-08 1993-04-27 Arch Development Corporation Cloning and expression of early growth regulatory protein genes
WO1995014772A1 (en) * 1993-11-12 1995-06-01 Kenichi Matsubara Gene signature
US5856128A (en) * 1996-08-15 1999-01-05 Incyte Pharmaceuticals, Inc. Human nucleic acid binding protein
WO1999033982A2 (en) * 1997-12-23 1999-07-08 Chiron Corporation Human genes and gene expression products i

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5206152A (en) * 1988-04-08 1993-04-27 Arch Development Corporation Cloning and expression of early growth regulatory protein genes
WO1995014772A1 (en) * 1993-11-12 1995-06-01 Kenichi Matsubara Gene signature
US5856128A (en) * 1996-08-15 1999-01-05 Incyte Pharmaceuticals, Inc. Human nucleic acid binding protein
WO1999033982A2 (en) * 1997-12-23 1999-07-08 Chiron Corporation Human genes and gene expression products i

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
GRISHIN N V: "The R3H motif: a domain that binds single-stranded nucleic acids", TIBS TRENDS IN BIOCHEMICAL SCIENCES,EN,ELSEVIER PUBLICATION, CAMBRIDGE, vol. 23, no. 9, 1 September 1998 (1998-09-01), pages 329 - 330, XP004146825, ISSN: 0968-0004 *
HILLIER ET AL.: "The WashU-Merck EST project", EMBL DATABASE ACC NO: R73178, 29 June 1995 (1995-06-29), XP002139426 *
JANSEN ET AL.: "Preferential binding of yeast Rad4.Rad23 complex to damaged DNA", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 50, 11 December 1998 (1998-12-11), pages 33111 - 33114, XP002139427 *
MOROZOV V ET AL: "A putative nucleic acid-binding domain in Bloom's and Werner's syndrome helicases", TIBS TRENDS IN BIOCHEMICAL SCIENCES,EN,ELSEVIER PUBLICATION, CAMBRIDGE, vol. 22, no. 11, 1 November 1997 (1997-11-01), pages 417 - 418, XP004094961, ISSN: 0968-0004 *

Also Published As

Publication number Publication date
WO2000044900A2 (en) 2000-08-03
JP2003521231A (en) 2003-07-15
EP1144625A2 (en) 2001-10-17
CA2359701A1 (en) 2000-08-03
AU2743400A (en) 2000-08-18

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