WO2000048986A2 - Sels de choline emettant peu d'odeurs - Google Patents

Sels de choline emettant peu d'odeurs Download PDF

Info

Publication number
WO2000048986A2
WO2000048986A2 PCT/US2000/004016 US0004016W WO0048986A2 WO 2000048986 A2 WO2000048986 A2 WO 2000048986A2 US 0004016 W US0004016 W US 0004016W WO 0048986 A2 WO0048986 A2 WO 0048986A2
Authority
WO
WIPO (PCT)
Prior art keywords
choline
choline salt
tma
salt
odor
Prior art date
Application number
PCT/US2000/004016
Other languages
English (en)
Other versions
WO2000048986A3 (fr
WO2000048986A8 (fr
Inventor
Thomas A. Jerrell
Mark H. Krackov
Original Assignee
Dcv, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dcv, Inc. filed Critical Dcv, Inc.
Priority to MXPA01008354A priority Critical patent/MXPA01008354A/es
Priority to AU40017/00A priority patent/AU4001700A/en
Priority to CA002363680A priority patent/CA2363680A1/fr
Priority to BR0008337-2A priority patent/BR0008337A/pt
Priority to EP00919309A priority patent/EP1154982A2/fr
Priority to KR1020017010516A priority patent/KR20010113698A/ko
Priority to JP2000599727A priority patent/JP2002537281A/ja
Publication of WO2000048986A2 publication Critical patent/WO2000048986A2/fr
Publication of WO2000048986A3 publication Critical patent/WO2000048986A3/fr
Publication of WO2000048986A8 publication Critical patent/WO2000048986A8/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives

Definitions

  • the inv ention is directed to a low odor choline salt product More particularly, the inv ention is directed to a choline salt product which does not release an amine or "fishv-Iike" odor, due to a reduction in the content of total t ⁇ methvlamine in the choline salt by purification
  • choline has a characteristic fishy odor which is deemed offensive to most humans In addition this odor reduces the initial palatabihty of the product, and can be conferred to the consumer, such that, if consumed in sufficient quantity, the consumer acquires a similar odor
  • Example 1 This preferred method is basically a form of crystallization
  • Example 2 sets forth a method of further purification by recrystalhzation
  • Other purification techniques include vacuum stripping (see Example 3), ion exchange and any other purification technique that will remove TMA known to those having skill in the art
  • the purified choline hydroxide was now converted to choline bitartrate by the addition of an equimolar quantity of tartaric acid, resulting in a choline bitartrate product, which did not emit a detectable amine-like odor

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne un sel de choline émettant peu d'odeurs purifié jusqu'à ce que la concentration d'équilibre du triméthylamine dans l'atmosphère au-dessus du sel de choline soit inférieure à 0,2 parties par milliards.
PCT/US2000/004016 1999-02-19 2000-02-17 Sels de choline emettant peu d'odeurs WO2000048986A2 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
MXPA01008354A MXPA01008354A (es) 1999-02-19 2000-02-17 Sales de colina de bajo aroma.
AU40017/00A AU4001700A (en) 1999-02-19 2000-02-17 Low odor choline salts
CA002363680A CA2363680A1 (fr) 1999-02-19 2000-02-17 Sels de choline emettant peu d'odeurs
BR0008337-2A BR0008337A (pt) 1999-02-19 2000-02-17 Produto de sal de colina
EP00919309A EP1154982A2 (fr) 1999-02-19 2000-02-17 Sels de choline emettant peu d'odeurs
KR1020017010516A KR20010113698A (ko) 1999-02-19 2000-02-17 저악취성 콜린염
JP2000599727A JP2002537281A (ja) 1999-02-19 2000-02-17 低臭気コリン塩

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US12067099P 1999-02-19 1999-02-19
US60/120,670 1999-02-19
US50597000A 2000-02-17 2000-02-17
US09/505,970 2000-02-17

Publications (3)

Publication Number Publication Date
WO2000048986A2 true WO2000048986A2 (fr) 2000-08-24
WO2000048986A3 WO2000048986A3 (fr) 2000-12-14
WO2000048986A8 WO2000048986A8 (fr) 2001-04-05

Family

ID=26818627

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/004016 WO2000048986A2 (fr) 1999-02-19 2000-02-17 Sels de choline emettant peu d'odeurs

Country Status (5)

Country Link
JP (1) JP2002537281A (fr)
BR (1) BR0008337A (fr)
CA (1) CA2363680A1 (fr)
MX (1) MXPA01008354A (fr)
WO (1) WO2000048986A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8992898B2 (en) 2010-04-17 2015-03-31 Shannon Elizabeth Klingman Antiperspirants and deodorants
WO2018002888A1 (fr) 2016-06-29 2018-01-04 Halo Life Science, Llc Procédés de fabrication de sels de choline à faible odeur d'un composé organique

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108707082A (zh) * 2018-07-10 2018-10-26 天津辰力工程设计有限公司 一种酒石酸氢胆碱制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5618978A (en) * 1995-02-10 1997-04-08 Japan Hydrazine Co., Ltd. Method of producing choline of a high purity

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1172920A1 (ru) * 1983-02-15 1985-08-15 Институт технической теплофизики АН УССР Способ получени сыпучей формы порошкообразного холинхлорида
RO93559B1 (ro) * 1986-03-29 1988-01-31 îNTREPRINDEREA DE MEDICAMENTE "SINTOFARM" Procedeu de obtinere a bitartratului de colina
RO111761B1 (ro) * 1994-08-09 1997-01-30 Sc Sicomed Sa Procedeu de obținere a bitartratului de colină
JPH1150286A (ja) * 1997-08-05 1999-02-23 Nippon Hidorajin Kogyo Kk 高純度有機カルボン酸・コリン塩及び高純度コリンの製造方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5618978A (en) * 1995-02-10 1997-04-08 Japan Hydrazine Co., Ltd. Method of producing choline of a high purity

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch, Week 198609 Derwent Publications Ltd., London, GB; Class B05, AN 1986-061191 XP002149295 & SU 1 172 920 A (AS UKR THERMOPHYS), 15 August 1985 (1985-08-15) *
DATABASE WPI Section Ch, Week 198828 Derwent Publications Ltd., London, GB; Class B05, AN 1988-196263 XP002149293 & RO 93 559 A (INTR MED COLORANTI SINTOFARM), 30 January 1988 (1988-01-30) *
DATABASE WPI Section Ch, Week 199736 Derwent Publications Ltd., London, GB; Class B05, AN 1997-392056 XP002149292 & RO 111 761 B (SC SICOMED SA), 30 January 1997 (1997-01-30) *
DATABASE WPI Section Ch, Week 199918 Derwent Publications Ltd., London, GB; Class B05, AN 1999-211282 XP002149294 & JP 11 050286 A (NIPPON HYDRAZINE IND LTD), 23 February 1999 (1999-02-23) *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8992898B2 (en) 2010-04-17 2015-03-31 Shannon Elizabeth Klingman Antiperspirants and deodorants
US9566223B2 (en) 2010-04-17 2017-02-14 Shannon Elizabeth Klingman Antiperspirants and deodorants
WO2018002888A1 (fr) 2016-06-29 2018-01-04 Halo Life Science, Llc Procédés de fabrication de sels de choline à faible odeur d'un composé organique
EP3478091A4 (fr) * 2016-06-29 2020-07-29 Halo Life Science, LLC Procédés de fabrication de sels de choline à faible odeur d'un composé organique
US10981928B2 (en) 2016-06-29 2021-04-20 Halo Life Science, Llc Methods of making low odor choline salts of an organic compound

Also Published As

Publication number Publication date
BR0008337A (pt) 2002-02-26
JP2002537281A (ja) 2002-11-05
WO2000048986A3 (fr) 2000-12-14
MXPA01008354A (es) 2003-06-06
WO2000048986A8 (fr) 2001-04-05
CA2363680A1 (fr) 2000-08-24

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