WO2000044344A2 - Antioxidative hautpflegemittel - Google Patents
Antioxidative hautpflegemittel Download PDFInfo
- Publication number
- WO2000044344A2 WO2000044344A2 PCT/EP2000/000451 EP0000451W WO0044344A2 WO 2000044344 A2 WO2000044344 A2 WO 2000044344A2 EP 0000451 W EP0000451 W EP 0000451W WO 0044344 A2 WO0044344 A2 WO 0044344A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- tocopherol
- skin
- antioxidant
- tea
- solution
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Definitions
- the invention relates to cosmetic preparations with a synergistic combination of antioxidants, which are used as skin care products.
- the skin As the external organ with the largest surface, the skin is particularly exposed to environmental influences. Since the skin primarily serves to protect the body, it has numerous natural protective barriers and regeneration processes. However, increasing levels of pollutants and UN pollution recently lead to excessive stress on the skin and sensitively disturb the natural regenerative capacity. Excessive exposure to high-energy UV rays both leads to acute damage, such as B. sunburn, as well as chronic changes, such as premature skin aging in the form of structural changes in the connective tissue. As a result of the excessive UV exposure, various reactive oxygen species form in the skin, which trigger or intensify numerous undesirable oxidative processes. In order to control the so-called "oxidative stress", the skin contains various antioxidant substances, for example superoxide dismutase, tocopherols and ascorbic acid.
- antioxidant substances for example superoxide dismutase, tocopherols and ascorbic acid.
- antioxidants prevent free oxygen radicals from attacking the lipid membranes of living cells ( Lipid peroxidation) or even irreversible damage to the genetic material.
- Recent research has shown that the external use of antioxidants can also reduce oxidative stress.
- the efforts of the cosmetics industry have promoted the development of personal care products that are highly effective and especially preventive contain physiologically harmless antioxidants Recently, multi-component systems with a synergistic effect have been used, whereby natural product extracts are being used more and more.
- a synergistic effect in the sense of the invention is understood to mean a cooperative effect of the antioxidants, This means that when the individual components are combined, the antioxidative effect is not additive, but is amplified many times over The antioxidative effect or the so-called antioxidative potential was determined using a chemiluminescence method in analogy to DD 249 618 A3.
- an antioxidant combination with a high synergistic effect has now been found, which is compatible with the physiological carriers and other ingredients of a skin care product and is odorless and color-neutral.
- Preparations containing this combination of antioxidants not only have excellent nourishing properties, but can also prevent skin aging through oxidative processes and / or improve the appearance of aging skin.
- the invention therefore relates to a cosmetic preparation, characterized in that a combination of (a) at least one tocopherol and / or is used as the antioxidant Tocopherol ester, (b) at least one gallic acid ester and (c) an extract of the tea plant is contained in a carrier suitable for topical application on the skin.
- the antioxidant mixture contains tocopherols and / or tocopherol esters as mandatory component (a).
- Organic compounds of different classes of compounds are used as antioxidants or oxidation inhibitors, which partially or completely inhibit changes caused by the action of oxygen or other oxidative processes. Because of their physiological safety and their easy accessibility, tocopherols and their esters are used in many ways as antioxidants in cosmetics and in food. Tocopherols, slightly yellowish to reddish liquids, are 3,4-dihydro-2H-1-benzopyran-6-ols, i.e. chroman-6-ols, which are substituted in the 2-position with a 4,8,12-trimethyltridecyl radical .
- Suitable tocopherols for the purposes of the invention are natural or synthetically accessible tocopherols in enantiomerically pure form or as a mixture of the stereoisomers, including ⁇ -, ⁇ -, ⁇ -, ⁇ - and ⁇ -tocopherols.
- a preferred variant of the preparation according to the invention is characterized in that a natural or synthetic ⁇ -tocopherol is present as component (a) in an amount of 0.005-2.0% by weight of the total composition. An amount of 0.1-1.0% by weight is considered to be particularly suitable.
- esters of tocopherols can be used. Suitable esters for the purposes of the invention are, inter alia, C 1 -C 22 alkyl or aryl esters, but also tocopheryl succinate, tocopheryl poly (oxyethylene) succinate, tocopheryl nicotinate and tocopheryl retinoate.
- ⁇ -tocopheryl acetate is also present in the preparation in an amount of 0.005-5.0% by weight, an amount of 0.1-2, 0% by weight is considered to be particularly preferred.
- the combination of the two components proves has proven to be particularly relevant with regard to the color neutrality of the cosmetic preparation.
- the quantitative ratio of tocopherol: ⁇ -tocopheryl acetate is usually 1: (2-10), a ratio of 1: (2-5) being particularly preferred.
- the preparations according to the invention also contain at least one gallic acid ester as mandatory component (b).
- Gallic acid esters have long been known for their anti-oxidative properties.
- the esters suitable for the purposes of the invention include the esters of gallic acid (3,4,5-trihydroxybenzoic acid) with aliphatic C 1 -C 22 alcohols.
- the most important representatives used in cosmetics, pharmaceuticals and food include methyl, ethyl, propyl, octyl, nonyl, dodecyl, cetyl, and stearyl gallate.
- a preferred variant of the preparations according to the invention is characterized in that propyl gallate is contained as the gallic acid ester in an amount of 0.005-2.0% by weight of the total composition.
- Particularly suitable is a product that is known under the trade name Danox ® 200th
- the third mandatory component (c) of the antioxidant mixture is an extract of the tea plant (Camellia sinensis, Theaceae). Leaves, leaf buds and the delicate stems of the tea bush, which are commercially available as "tea”, are usually used for this. However, other parts of the plant could also be used according to the invention (seeds, fruits, flowers, stems, barks, roots) A distinction is made between green, unfermented tea and black, fermented tea.
- the ingredients in the tea include numerous polyphenol compounds that are responsible for its typical aroma.
- the tea extracts can be obtained by extraction or distillation.
- the solvents usually used for this purpose are suitable for the extraction, the use of water or water / alcohol mixtures being preferred for the purposes of the invention.
- the tannin content increases with the extraction time. High-molecular or polymeric catechin and tannin tannins then dissolve, which give the extracts the characteristic dark color.
- Tea extracts obtained by distillation are almost colorless and are particularly suitable for the production of color-neutral and storage-stable cosmetics.
- the active substance content in the distillates is generally much lower than in the extracts.
- a preferred embodiment of the preparation is characterized in that the extract of the tea plant contains the steam distillate of leaves of green, unfermented tea from Camellia Sinensis in an amount of 1.0-20.0% by weight in the preparation. Quantities of 1.0-5.0% by weight are particularly preferred. These steam distillates are colorless and contain, in addition to the volatile essential oils, theaflavin, the active substance content usually being between 0.01-0.5% by weight. The antioxidative potential of 0.00014 vitamin E units is in the very low range (Table 1).
- the antioxidant combination is contained in the physiologically compatible carriers that are customary for cosmetic formulations.
- the usual care ingredients oils, waxes, fats, lipid-replenishing substances, thickeners, emulsifiers, substances and fragrances suitable as sun protection filters can be included.
- the composition can be in the form of an aqueous or alcoholic solution, as a gel, oil, W / O or O / W emulsifier. or as an aerosol.
- suitable formulation basics reference is made here to the formulations customary in cosmetics (K. Schrader, Basics and Formulations of Cosmetics, 2nd edition, Wegig Buch Verlag, Heidelberg 1989, pages 424-437, 442-451, 456 -465).
- the invention also relates to the use of the preparation according to the invention for the care treatment of the skin.
- the antioxidant combination can prevent the consequences of oxidative stress and have a beneficial effect on skin regeneration processes.
- the emulsions described below are prepared by methods generally used in cosmetics.
- the antioxidative potential characterizes the "radical-catching" properties of a substance or a mixture of substances.
- the method is based on the photo-chemiluminescence of luminol (3-aminophthalic acid hydrazide) induced by oxygen radicals in the absence and in the presence of certain radical scavengers (antioxidants).
- the photochemiluminescence in the absence of antioxidants serves as a blank.
- a decrease in the chemiluminescence of the luminol is observed in the presence of radical scavengers.
- a defined amount of vitamin E is added and the chemiluminescence is determined in the presence of this radical scavenger. This value serves as a reference and is referred to as 1 nitamine E unit.
- the decrease in luminescence caused by the test substance is related to the decrease in luminescence by vitamin E and expressed in vitamin E units.
- the antioxidative potential of numerous substances and substance mixtures can be determined.
- the apparatus basically consists of 2 components, a radical generator and a detector system.
- Standard laboratory material syringe filter, 0.2 ⁇ m, from Millipore
- the analytically precisely weighed amount (approx. 0.5 g) of the sample to be analyzed was made up to the mark with methanol.
- the solution was treated with ultrasound for 10 min and then filtered.
- the calibration was carried out using a vitamin E standard.
- an analytically precisely weighed amount of d, l- ⁇ -tocopherol 80 ⁇ 5 mg was made up to the mark with methanol. This solution was diluted with ethanol to give a content of 12 mg L.
- the chemiluminescence of the blank solution was determined. If the measured values remained stable, the actual measurement could be started. The measurement time was 180 seconds per sample. The software automatically took the empty value (integral under the curve) into account in the subsequent measurements.
- the system was then calibrated to vitamin E standards (see 4.3), i.e. determined the chemiluminescence of the three vitamin E standards.
- the chemiluminescence of the measurement solutions (F) of the samples to be examined was then determined.
- the inhibition of chemiluminescence resulted from the integral of the blank value minus the integral of the measurement solution normalized to the integral of the blank value.
- the curves determined for the measurement solutions were compared to the calibration curves for vitamin E.
- the specific inhibition of chemiluminescence for a substance sample was expressed in vitamin E equivalents per g sample (mg Vit. E Ig sample) and referred to as the so-called antioxidative potential (AOP).
- Table 1 summarizes, by way of example, the results of the active compound combination (5) which is contained in the formulation examples according to the invention and has a particularly pronounced synergism, that is to say a “booster effect”.
- the recipe contains the antioxidant mixture according to the invention.
- Vitamin E acetate 0.50
- the recipe contains the antioxidant mixture according to the invention.
- Cutina ® MD-V INCI Stearyl stearate Manufacturer: Henkel KGaA
- Vitamin E acetate INCI Tocopheryl acetate Manufacturer: BASF 8) Controx ® KS
- Herbasol ® distillate tea green special handle without alcohol INCI: Aqua, camellia sinensis extract, benzoic acid, polysorbate-20 steam distillate: with 0.75% by weight benzoic acid, approx. 2% by weight polysorbate 20 100 kg distillate contain the volatile Components of 100 kg of green tea Active ingredient content: approx. 0.01 - 0.5% by weight
- Danox ® 200 INCI propyl gallate manufacturer: IFSC (Rahn)
- Cegesoft ® C24 INCI Octyl palmitate Manufacturer: Henkel (Grünau)
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE50001610T DE50001610D1 (de) | 1999-01-30 | 2000-01-21 | Antioxidative hautpflegemittel |
JP2000595648A JP2002535348A (ja) | 1999-01-30 | 2000-01-21 | 抗酸化スキンケア生成物 |
AU32762/00A AU3276200A (en) | 1999-01-30 | 2000-01-21 | Antioxidant skin care products |
EP00910599A EP1146853B1 (de) | 1999-01-30 | 2000-01-21 | Antioxidative hautpflegemittel |
AT00910599T ATE235885T1 (de) | 1999-01-30 | 2000-01-21 | Antioxidative hautpflegemittel |
CA002360727A CA2360727A1 (en) | 1999-01-30 | 2000-01-21 | Antioxidant skin care products |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19903716A DE19903716A1 (de) | 1999-01-30 | 1999-01-30 | Antioxidative Hautpflegemittel |
DE19903716.7 | 1999-01-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2000044344A2 true WO2000044344A2 (de) | 2000-08-03 |
WO2000044344A3 WO2000044344A3 (de) | 2001-01-04 |
Family
ID=7895894
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2000/000451 WO2000044344A2 (de) | 1999-01-30 | 2000-01-21 | Antioxidative hautpflegemittel |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP1146853B1 (de) |
JP (1) | JP2002535348A (de) |
CN (1) | CN1345225A (de) |
AT (1) | ATE235885T1 (de) |
AU (1) | AU3276200A (de) |
CA (1) | CA2360727A1 (de) |
DE (2) | DE19903716A1 (de) |
WO (1) | WO2000044344A2 (de) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003095856A (ja) * | 2001-09-26 | 2003-04-03 | Nonogawa Shoji Kk | 皮膚外用剤 |
WO2003035025A1 (de) * | 2001-07-10 | 2003-05-01 | Cognis Japan Ltd. | Zusammensetzung auf ölbasis mit einem gehalt an sterinen |
US7037535B2 (en) | 2002-11-19 | 2006-05-02 | Kimberly-Clark Worldwide, Inc. | Method and composition for neutralizing house dust mite feces |
US7585518B2 (en) | 2002-11-19 | 2009-09-08 | Kimberly-Clark Worldwide, Inc. | Products and methods for maintaining or increasing ceramide levels in skin |
FR3016168A1 (fr) * | 2014-01-07 | 2015-07-10 | Oleos | Composition grasse stable comprenant des antioxydants, son procede de preparation et ses utilisations |
DE102015117981A1 (de) * | 2014-10-22 | 2016-04-28 | Tissma UG (haftungsbeschränkt) | Handhygiene-Kosmetikum |
US10022308B2 (en) | 2003-07-22 | 2018-07-17 | Kimberly-Clark Worldwide, Inc. | Wipe and methods for improving skin health |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1267813A2 (de) * | 2000-03-31 | 2003-01-02 | Henkel Kommanditgesellschaft auf Aktien | Verwendung von protease-inhibitoren in der kosmetik und pharmazie |
DE10064818A1 (de) * | 2000-12-22 | 2002-06-27 | Basf Ag | Verwendung von Chroman-Derivaten in kosmetischen oder dermatologischen Zubreitungen |
EP1297821A1 (de) * | 2001-10-01 | 2003-04-02 | Hive of Beauty (Europe) BVBA | Hautpflegemittel |
DE102007036499A1 (de) * | 2007-08-01 | 2009-02-05 | Henkel Ag & Co. Kgaa | Naturkosmetisches Haarbehandlungsmittel |
CN102579307B (zh) * | 2012-03-31 | 2013-07-31 | 两面针(扬州)酒店用品有限公司 | 中药两面针滋润止痒沐浴露 |
FR3030231B1 (fr) * | 2014-12-23 | 2018-08-24 | L'oreal | Utilisation d'un ester d'acide gras pour matifier la peau et composition comprenant cet ester |
FR3045339B1 (fr) * | 2015-12-22 | 2019-11-01 | L'oreal | Composition photoprotectrice a base d'un ester gras; utilisation dudit compose pour augmenter le facteur de protection solaire |
US10835456B2 (en) | 2016-07-19 | 2020-11-17 | Basf Se | Propyl gallate-containing vitamin preparations |
KR102356657B1 (ko) * | 2019-10-28 | 2022-01-26 | 임정훈 | 녹차수를 함유하는 유아용 화장품 |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4673530A (en) * | 1983-05-30 | 1987-06-16 | Mitsui Norin Co., Ltd. | Process for the production of a natural antioxidant obtained from tea leaves |
EP0440398A1 (de) * | 1990-01-29 | 1991-08-07 | JOHNSON & JOHNSON CONSUMER PRODUCTS, INC. | Hautpflegezusammensetzungen |
EP0659402A2 (de) * | 1993-12-21 | 1995-06-28 | INDENA S.p.A. | Karotenoide und Prokarotenoide enthaltende Zusammensetzungen kombiniert mit Polyphenolen zur Vorbeugung von durch abnormale freie Radikalbildung verursachten Schäden |
WO1999030682A1 (en) * | 1997-12-17 | 1999-06-24 | Color Access, Inc. | Novel antioxidant mixture |
US5972993A (en) * | 1998-03-20 | 1999-10-26 | Avon Products, Inc. | Composition and method for treating rosacea and sensitive skin with free radical scavengers |
DE19827624A1 (de) * | 1998-06-20 | 1999-12-23 | Beiersdorf Ag | Verwendung von einem mit einem Gehalt an Catecinen oder einem Gehalt an Extrakt von grünem Tee in kosmetischen Zubereitungen zur Bräunung der Haut |
WO1999066881A2 (de) * | 1998-06-24 | 1999-12-29 | Coty B.V. | Kosmetische wirkstoffzubereitung mit hohem radikalschutzfaktor |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0292258A (ja) * | 1988-09-26 | 1990-04-03 | Sankyo Co Ltd | 食品の品質保持剤 |
JPH0899827A (ja) * | 1994-09-29 | 1996-04-16 | Shiseido Co Ltd | 皮膚外用剤 |
-
1999
- 1999-01-30 DE DE19903716A patent/DE19903716A1/de not_active Withdrawn
-
2000
- 2000-01-21 EP EP00910599A patent/EP1146853B1/de not_active Expired - Lifetime
- 2000-01-21 JP JP2000595648A patent/JP2002535348A/ja active Pending
- 2000-01-21 CN CN00803125A patent/CN1345225A/zh active Pending
- 2000-01-21 AT AT00910599T patent/ATE235885T1/de not_active IP Right Cessation
- 2000-01-21 AU AU32762/00A patent/AU3276200A/en not_active Abandoned
- 2000-01-21 DE DE50001610T patent/DE50001610D1/de not_active Expired - Lifetime
- 2000-01-21 WO PCT/EP2000/000451 patent/WO2000044344A2/de active IP Right Grant
- 2000-01-21 CA CA002360727A patent/CA2360727A1/en not_active Abandoned
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4673530A (en) * | 1983-05-30 | 1987-06-16 | Mitsui Norin Co., Ltd. | Process for the production of a natural antioxidant obtained from tea leaves |
EP0440398A1 (de) * | 1990-01-29 | 1991-08-07 | JOHNSON & JOHNSON CONSUMER PRODUCTS, INC. | Hautpflegezusammensetzungen |
EP0659402A2 (de) * | 1993-12-21 | 1995-06-28 | INDENA S.p.A. | Karotenoide und Prokarotenoide enthaltende Zusammensetzungen kombiniert mit Polyphenolen zur Vorbeugung von durch abnormale freie Radikalbildung verursachten Schäden |
WO1999030682A1 (en) * | 1997-12-17 | 1999-06-24 | Color Access, Inc. | Novel antioxidant mixture |
US5972993A (en) * | 1998-03-20 | 1999-10-26 | Avon Products, Inc. | Composition and method for treating rosacea and sensitive skin with free radical scavengers |
DE19827624A1 (de) * | 1998-06-20 | 1999-12-23 | Beiersdorf Ag | Verwendung von einem mit einem Gehalt an Catecinen oder einem Gehalt an Extrakt von grünem Tee in kosmetischen Zubereitungen zur Bräunung der Haut |
WO1999066881A2 (de) * | 1998-06-24 | 1999-12-29 | Coty B.V. | Kosmetische wirkstoffzubereitung mit hohem radikalschutzfaktor |
Non-Patent Citations (2)
Title |
---|
DATABASE WPI Week 199625 Derwent Publications Ltd., London, GB; AN 1996-246866 XP002144762 & JP 08 099827 A (SHISEIDO CO) * |
PATENT ABSTRACTS OF JAPAN vol. 014, no. 290 (C-0731) & JP 02 092258 A (SANKYO CO) * |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003035025A1 (de) * | 2001-07-10 | 2003-05-01 | Cognis Japan Ltd. | Zusammensetzung auf ölbasis mit einem gehalt an sterinen |
JP2003095856A (ja) * | 2001-09-26 | 2003-04-03 | Nonogawa Shoji Kk | 皮膚外用剤 |
US7037535B2 (en) | 2002-11-19 | 2006-05-02 | Kimberly-Clark Worldwide, Inc. | Method and composition for neutralizing house dust mite feces |
US7585518B2 (en) | 2002-11-19 | 2009-09-08 | Kimberly-Clark Worldwide, Inc. | Products and methods for maintaining or increasing ceramide levels in skin |
US7838025B2 (en) | 2002-11-19 | 2010-11-23 | Kimberly-Clark Worldwide, Inc. | Products and methods for maintaining or increasing ceramide levels in skin |
US10022308B2 (en) | 2003-07-22 | 2018-07-17 | Kimberly-Clark Worldwide, Inc. | Wipe and methods for improving skin health |
FR3016168A1 (fr) * | 2014-01-07 | 2015-07-10 | Oleos | Composition grasse stable comprenant des antioxydants, son procede de preparation et ses utilisations |
DE102015117981A1 (de) * | 2014-10-22 | 2016-04-28 | Tissma UG (haftungsbeschränkt) | Handhygiene-Kosmetikum |
Also Published As
Publication number | Publication date |
---|---|
EP1146853B1 (de) | 2003-04-02 |
WO2000044344A3 (de) | 2001-01-04 |
AU3276200A (en) | 2000-08-18 |
DE19903716A1 (de) | 2000-08-03 |
EP1146853A2 (de) | 2001-10-24 |
DE50001610D1 (de) | 2003-05-08 |
CN1345225A (zh) | 2002-04-17 |
JP2002535348A (ja) | 2002-10-22 |
CA2360727A1 (en) | 2000-08-03 |
ATE235885T1 (de) | 2003-04-15 |
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