WO2000042060A1 - Bis-amino acid sulfonamides containing n-terminally a substituted benzyl group as hiv protease inhibitors - Google Patents

Bis-amino acid sulfonamides containing n-terminally a substituted benzyl group as hiv protease inhibitors Download PDF

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Publication number
WO2000042060A1
WO2000042060A1 PCT/US2000/000820 US0000820W WO0042060A1 WO 2000042060 A1 WO2000042060 A1 WO 2000042060A1 US 0000820 W US0000820 W US 0000820W WO 0042060 A1 WO0042060 A1 WO 0042060A1
Authority
WO
WIPO (PCT)
Prior art keywords
compound
compound according
mmol
formula
hiv
Prior art date
Application number
PCT/US2000/000820
Other languages
English (en)
French (fr)
Inventor
Robert F. Kaltenbach
George L. Trainor
Original Assignee
Dupont Pharmaceuticals Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to HU0105235A priority Critical patent/HUP0105235A3/hu
Priority to EP00905604A priority patent/EP1140983A1/en
Priority to BR0007854-9A priority patent/BR0007854A/pt
Priority to SK952-2001A priority patent/SK9522001A3/sk
Priority to KR1020017008803A priority patent/KR20010101478A/ko
Priority to JP2000593627A priority patent/JP2002536298A/ja
Application filed by Dupont Pharmaceuticals Company filed Critical Dupont Pharmaceuticals Company
Priority to AU27257/00A priority patent/AU2725700A/en
Priority to CA002353088A priority patent/CA2353088A1/en
Priority to PL00349774A priority patent/PL349774A1/xx
Priority to IL14376300A priority patent/IL143763A0/xx
Publication of WO2000042060A1 publication Critical patent/WO2000042060A1/en
Priority to NO20013338A priority patent/NO20013338L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
PCT/US2000/000820 1999-01-13 2000-01-13 Bis-amino acid sulfonamides containing n-terminally a substituted benzyl group as hiv protease inhibitors WO2000042060A1 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
EP00905604A EP1140983A1 (en) 1999-01-13 2000-01-13 Bis-amino acid sulfonamides containing n-terminally a fluoro-substituted benzyl group as hiv protease inhibitors
BR0007854-9A BR0007854A (pt) 1999-01-13 2000-01-13 Compostos sulfonamidas bis-aminoácidos inibidores de protease de hiv, composição farmacêutica e método de tratamento de infecções por hiv
SK952-2001A SK9522001A3 (en) 1999-01-13 2000-01-13 Bis-amino acid sulfonamides containing n-terminally a substituted benzyl group as hiv protease inhibitors
KR1020017008803A KR20010101478A (ko) 1999-01-13 2000-01-13 Ｈｉｖ 프로테아제 억제제로서 ｎ-말단에 치환된 벤질기를갖는 비스-아미노산 술폰아미드
JP2000593627A JP2002536298A (ja) 1999-01-13 2000-01-13 Ｈｉｖプロテアーゼ阻害剤としてｎ末端置換ベンジル基を含むビス−アミノ酸スルホンアミド
HU0105235A HUP0105235A3 (en) 1999-01-13 2000-01-13 Bis-amino acid sulfonamides containing n-terminally a substituted benzyl group as hiv protease inhibitors, pharmaceutical compositions comprising thereof and their use
AU27257/00A AU2725700A (en) 1999-01-13 2000-01-13 Bis-amino acid sulfonamides containing n-terminally a substituted benzyl group as hiv protease inhibitors
CA002353088A CA2353088A1 (en) 1999-01-13 2000-01-13 Bis-amino acid sulfonamides containing n-terminally a substituted benzyl group as hiv protease inhibitors
PL00349774A PL349774A1 (en) 1999-01-13 2000-01-13 Bis-amino acid sulfonamides containing n-terminally a substituted benzyl group as hiv protease inhibitors
IL14376300A IL143763A0 (en) 1999-01-13 2000-01-13 Bis-amino acid sulfonamides containing n-terminally a substituted benzyl group as hiv protease inhibitors
NO20013338A NO20013338L (no) 1999-01-13 2001-07-05 Bis-aminosyresulfonamider inneholdende N-terminalt en substituert benzylgruppe som HIV-proteaseinhibitorer

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11574699P 1999-01-13 1999-01-13
US60/115,746 1999-01-13

Publications (1)

Publication Number Publication Date
WO2000042060A1 true WO2000042060A1 (en) 2000-07-20

Family

ID=22363180

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/000820 WO2000042060A1 (en) 1999-01-13 2000-01-13 Bis-amino acid sulfonamides containing n-terminally a substituted benzyl group as hiv protease inhibitors

Country Status (15)

Country Link
EP (1) EP1140983A1 (hu)
JP (1) JP2002536298A (hu)
KR (1) KR20010101478A (hu)
CN (1) CN1336934A (hu)
AU (1) AU2725700A (hu)
BR (1) BR0007854A (hu)
CA (1) CA2353088A1 (hu)
CZ (1) CZ20012435A3 (hu)
HU (1) HUP0105235A3 (hu)
IL (1) IL143763A0 (hu)
NO (1) NO20013338L (hu)
PL (1) PL349774A1 (hu)
SK (1) SK9522001A3 (hu)
TR (1) TR200102033T2 (hu)
WO (1) WO2000042060A1 (hu)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002006292A1 (en) * 2000-07-19 2002-01-24 Bristol-Myers Sqibb Company Phosphate esters of bis-amino acid sulfonamides containing substituted benzyl amines
WO2002006190A2 (en) * 2000-07-19 2002-01-24 Bristol-Myers Squibb Pharma Company Crystalline and salt forms of an hiv protease inhibitor
WO2002010124A2 (en) * 2000-07-19 2002-02-07 Dupont Pharmaceuticals Company Salt forms of an hiv protease inhibitor
EP1188766A1 (en) * 1995-03-10 2002-03-20 G.D. Searle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US6861539B1 (en) 1995-03-10 2005-03-01 G. D. Searle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US7339078B2 (en) 1995-03-10 2008-03-04 G.D. Searle Llc Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994004492A1 (en) * 1992-08-25 1994-03-03 G.D. Searle & Co. Hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
WO1995006030A1 (en) * 1993-08-24 1995-03-02 G.D. Searle & Co. Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors
WO1996028464A1 (en) * 1995-03-10 1996-09-19 G.D. Searle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994004492A1 (en) * 1992-08-25 1994-03-03 G.D. Searle & Co. Hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
WO1995006030A1 (en) * 1993-08-24 1995-03-02 G.D. Searle & Co. Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors
WO1996028464A1 (en) * 1995-03-10 1996-09-19 G.D. Searle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1188766A1 (en) * 1995-03-10 2002-03-20 G.D. Searle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US6683210B2 (en) 1995-03-10 2004-01-27 G. D. Searle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US6861539B1 (en) 1995-03-10 2005-03-01 G. D. Searle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US7161033B2 (en) 1995-03-10 2007-01-09 G. D. Searle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US7339078B2 (en) 1995-03-10 2008-03-04 G.D. Searle Llc Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
WO2002006292A1 (en) * 2000-07-19 2002-01-24 Bristol-Myers Sqibb Company Phosphate esters of bis-amino acid sulfonamides containing substituted benzyl amines
WO2002006190A2 (en) * 2000-07-19 2002-01-24 Bristol-Myers Squibb Pharma Company Crystalline and salt forms of an hiv protease inhibitor
WO2002010124A2 (en) * 2000-07-19 2002-02-07 Dupont Pharmaceuticals Company Salt forms of an hiv protease inhibitor
WO2002006190A3 (en) * 2000-07-19 2002-06-20 Bristol Myers Squibb Pharma Co Crystalline and salt forms of an hiv protease inhibitor
WO2002010124A3 (en) * 2000-07-19 2003-05-01 Du Pont Pharm Co Salt forms of an hiv protease inhibitor
US6617310B2 (en) 2000-07-19 2003-09-09 Bristol-Myers Squibb Pharma Company Phosphate esters of bis-amino acid sulfonamides containing substituted benzyl amines

Also Published As

Publication number Publication date
TR200102033T2 (tr) 2001-12-21
NO20013338L (no) 2001-09-13
CN1336934A (zh) 2002-02-20
EP1140983A1 (en) 2001-10-10
JP2002536298A (ja) 2002-10-29
HUP0105235A2 (hu) 2002-04-29
PL349774A1 (en) 2002-09-09
KR20010101478A (ko) 2001-11-14
SK9522001A3 (en) 2002-03-05
NO20013338D0 (no) 2001-07-05
BR0007854A (pt) 2002-01-15
IL143763A0 (en) 2002-04-21
AU2725700A (en) 2000-08-01
HUP0105235A3 (en) 2002-08-28
CA2353088A1 (en) 2000-07-20
CZ20012435A3 (cs) 2002-02-13

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