WO2000017232A3 - Regulatorisches protein aus humanen keratinozyten - Google Patents

Regulatorisches protein aus humanen keratinozyten Download PDF

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Publication number
WO2000017232A3
WO2000017232A3 PCT/DE1999/002865 DE9902865W WO0017232A3 WO 2000017232 A3 WO2000017232 A3 WO 2000017232A3 DE 9902865 W DE9902865 W DE 9902865W WO 0017232 A3 WO0017232 A3 WO 0017232A3
Authority
WO
WIPO (PCT)
Prior art keywords
sequence
seq
protein
amino acid
nucleic acid
Prior art date
Application number
PCT/DE1999/002865
Other languages
English (en)
French (fr)
Other versions
WO2000017232A2 (de
Inventor
Michael Kramer
Michael Bechtel
Jeanette Reinartz
Birgit Schaefer
Reinhard Wallich
Original Assignee
Michael Kramer
Michael Bechtel
Jeanette Reinartz
Birgit Schaefer
Reinhard Wallich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Michael Kramer, Michael Bechtel, Jeanette Reinartz, Birgit Schaefer, Reinhard Wallich filed Critical Michael Kramer
Priority to AU11491/00A priority Critical patent/AU1149100A/en
Priority to DE19981873T priority patent/DE19981873D2/de
Priority to EP99969420A priority patent/EP1114157A2/de
Priority to CA002342957A priority patent/CA2342957A1/en
Priority to JP2000574140A priority patent/JP2002526060A/ja
Publication of WO2000017232A2 publication Critical patent/WO2000017232A2/de
Publication of WO2000017232A3 publication Critical patent/WO2000017232A3/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Die Erfindung betrifft ein isoliertes Polypeptid, das einem natürlicherweise in humanen Keratinozyten vorkommenden und im aktivierten Zustand der Keratinozyten verstärkt exprimierten Protein gleicht oder ähnlich (d.h. in Funktion und Wirkung gleich) ist. Sie betrifft außerdem eine isolierte Nukleinsäure, die ein solches für humane Keratinozyten typisches Polypeptid bzw. Protein kodiert, sowie die Verwendung dieses Polypeptids und dieser Nukleinsäure für nachweisende, insbesondere diagnostische, und/oder für therapeutische Zwecke bzw. die Verwendung von Reagenzien, insbesondere rekombinanten Vektormolekülen und Antikörpern, gegen solche Moleküle. Das erfindungsgemäße Protein weist entweder die im Sequenzprotokoll SEQ ID NO:2 oder die im Sequenzprotokoll SEQ ID NO:3 dargestellte Aminosäuresequenz oder ein durch Aminosäuresubstitution, -deletion, -insertion oder -inversion daraus entstandenes Allel oder Derivat dieser Aminosäuresequenz auf, und die erfindungsgemäße Nukleinsäure weist entweder die im Sequenzprotokoll SEQ ID NO:1 oder die im Sequenzprotokoll SEQ ID NO:4 dargestellte Nukleotidsequenz oder eine hierzu komplementäre Nuleotidsequenz oder eine Teilsequenz einer dieser Nukleotidsequenzen oder eine ganz oder teilweise mit einer der vorgenannten Nukleotidsequenzen hybridisierenden Nukleotidsequenz auf.
PCT/DE1999/002865 1998-09-19 1999-09-06 Regulatorisches protein aus humanen keratinozyten WO2000017232A2 (de)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU11491/00A AU1149100A (en) 1998-09-19 1999-09-06 Regulatory protein from human keratinocytes
DE19981873T DE19981873D2 (de) 1998-09-19 1999-09-06 Regulatorisches Protein aus humanen Keratinozhyten
EP99969420A EP1114157A2 (de) 1998-09-19 1999-09-06 Regulatorisches protein aus humanen keratinozyten
CA002342957A CA2342957A1 (en) 1998-09-19 1999-09-06 Regulatory protein from human keratinocytes
JP2000574140A JP2002526060A (ja) 1998-09-19 1999-09-06 ヒトのケラチノサイトからの調節タンパク質

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19842863.4 1998-09-19
DE19842863A DE19842863A1 (de) 1998-09-19 1998-09-19 Regulatorisches Protein aus humanen Keratinozyten

Publications (2)

Publication Number Publication Date
WO2000017232A2 WO2000017232A2 (de) 2000-03-30
WO2000017232A3 true WO2000017232A3 (de) 2000-10-12

Family

ID=7881448

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1999/002865 WO2000017232A2 (de) 1998-09-19 1999-09-06 Regulatorisches protein aus humanen keratinozyten

Country Status (6)

Country Link
EP (1) EP1114157A2 (de)
JP (1) JP2002526060A (de)
AU (1) AU1149100A (de)
CA (1) CA2342957A1 (de)
DE (2) DE19842863A1 (de)
WO (1) WO2000017232A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1240194A2 (de) * 1999-11-24 2002-09-18 Sugen, Inc. Protein kinasen und protein kinase-ahnliche enzyme identifiziert durch genomisches sequenzieren
EP1272640A2 (de) * 2000-03-24 2003-01-08 Millennium Pharmaceuticals, Inc. 3714, 16742, 23546, and 13887 protein kinase moleküle und deren verwendungen
GB0400122D0 (en) * 2004-01-06 2004-02-11 Badrilla Ltd Method of quantifying binding
US6946028B1 (en) * 2004-09-07 2005-09-20 Kerr-Mcgee Chemical Llc Surface-treated pigments
JP2015072226A (ja) * 2013-10-03 2015-04-16 住友ベークライト株式会社 検査方法

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
EMBL DATABASE; EMROD.MM11494; ACCESSION-NO.: U11494, 12 December 1994 (1994-12-12) *
JAEGER, C.: "Identification of a novel transmembrane-protein (pKe#192/MAP17) expressed by human keratinocytes in the upper stratum granulosum of the epidermis", JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 112, no. 4, April 1999 (1999-04-01), pages 574, XP000909987 *
JIANG, C.-K., ET AL.: "Epidermal growth factor and transforming growth factor alpha specifically induce the activation- and hyperproliferation-associated keratins 6 and 16", PROC.NATL.ACAD.SCI.USA, vol. 90, no. 14, 1993, pages 6786 - 6790, XP000910179 *
KNAPP, B. ET AL.: "Three cDNA sequences of mouse type I keratins", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 262, no. 2, 1987, pages 938 - 945, XP000910011 *
KOMINE, M. ET AL.: "The activated keratinocytes", ACTA DERMATOVENEROLOGICA A.P.A., vol. 4, no. 4, 1995, pages 169 - 173, XP000915531 *
RUIZ, J.C. ET AL.: "Identification of novel protein kinases expressed in the myocardium of the developing mouse heart", MECHANISMS OF DEVELOPMENT, vol. 48, no. 3, 1994, pages 153 - 164, XP000909836 *

Also Published As

Publication number Publication date
DE19842863A1 (de) 2000-04-27
JP2002526060A (ja) 2002-08-20
CA2342957A1 (en) 2000-03-30
WO2000017232A2 (de) 2000-03-30
DE19981873D2 (de) 2002-01-24
EP1114157A2 (de) 2001-07-11
AU1149100A (en) 2000-04-10

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