WO1999061640A3 - Vecteur derive par aav - Google Patents

Vecteur derive par aav Download PDF

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Publication number
WO1999061640A3
WO1999061640A3 PCT/GB1999/001633 GB9901633W WO9961640A3 WO 1999061640 A3 WO1999061640 A3 WO 1999061640A3 GB 9901633 W GB9901633 W GB 9901633W WO 9961640 A3 WO9961640 A3 WO 9961640A3
Authority
WO
WIPO (PCT)
Prior art keywords
derived vector
aav derived
aav
vector
encapsidating
Prior art date
Application number
PCT/GB1999/001633
Other languages
English (en)
Other versions
WO1999061640A2 (fr
Inventor
Robert James Anderson
Hugh Grant Prentice
Ian Duncan Macdonald
Original Assignee
Univ London
Robert James Anderson
Hugh Grant Prentice
Ian Duncan Macdonald
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ London, Robert James Anderson, Hugh Grant Prentice, Ian Duncan Macdonald filed Critical Univ London
Publication of WO1999061640A2 publication Critical patent/WO1999061640A2/fr
Publication of WO1999061640A3 publication Critical patent/WO1999061640A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Cette invention a trait à un vecteur viral adéno-associé contenant un transgène et encapsidant une protéine à activité de type adénovirus E4 ORF6.
PCT/GB1999/001633 1998-05-22 1999-05-21 Vecteur derive par aav WO1999061640A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9811171.9A GB9811171D0 (en) 1998-05-22 1998-05-22 Viral vector
GB9811171.9 1998-05-22

Publications (2)

Publication Number Publication Date
WO1999061640A2 WO1999061640A2 (fr) 1999-12-02
WO1999061640A3 true WO1999061640A3 (fr) 2000-01-27

Family

ID=10832634

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1999/001633 WO1999061640A2 (fr) 1998-05-22 1999-05-21 Vecteur derive par aav

Country Status (2)

Country Link
GB (1) GB9811171D0 (fr)
WO (1) WO1999061640A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10056210A1 (de) * 2000-11-13 2002-05-29 Arimedes Biotechnology Gmbh Virales Expressionssystem
ES2335657T3 (es) * 2002-04-25 2010-03-31 Crucell Holland B.V. Medios y metodos para la produccion de vectores de adenovirus.
JP2012522762A (ja) 2009-04-01 2012-09-27 ザ メディカル リサーチ， インフラストラクチャー， アンド ヘルス サーヴィシーズ ファンド オブ ザ テル アヴィヴ メディカル センター ケラチノサイトの増殖および分化を調節する方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996000587A1 (fr) * 1994-06-30 1996-01-11 University Of Pittsburgh Capsides de virus adeno-associe utilises comme vecteurs pour le transfert moleculaire
WO1996022378A1 (fr) * 1995-01-20 1996-07-25 Rhone-Poulenc Rorer S.A. Cellules pour la production d'adenovirus recombinants
WO1996039530A2 (fr) * 1995-06-05 1996-12-12 The Trustees Of The University Of Pennsylvania Adenovirus et virus adeno-associe de recombinaison, lignees cellulaires et leurs procedes de production et d'utilisation
WO1997009441A2 (fr) * 1995-09-08 1997-03-13 Genzyme Corporation Vecteurs aav ameliores pour la therapie genique

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996000587A1 (fr) * 1994-06-30 1996-01-11 University Of Pittsburgh Capsides de virus adeno-associe utilises comme vecteurs pour le transfert moleculaire
WO1996022378A1 (fr) * 1995-01-20 1996-07-25 Rhone-Poulenc Rorer S.A. Cellules pour la production d'adenovirus recombinants
WO1996039530A2 (fr) * 1995-06-05 1996-12-12 The Trustees Of The University Of Pennsylvania Adenovirus et virus adeno-associe de recombinaison, lignees cellulaires et leurs procedes de production et d'utilisation
WO1997009441A2 (fr) * 1995-09-08 1997-03-13 Genzyme Corporation Vecteurs aav ameliores pour la therapie genique

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
FERRARI F. K. ET AL.: "SECOND-STRAND SYNTHESIS IS A RATE-LIMITING STEP FOR EFFICIENT TRANSDUCTION BY RECOMBINANT ADENO-ASSOCIATED VIRUS VECTORS", JOURNAL OF VIROLOGY,US,THE AMERICAN SOCIETY FOR MICROBIOLOGY, vol. 70, no. 5, pages 3227-3234, XP000570467, ISSN: 0022-538X *
FISHER K. J. ET AL.: "TRANSDUCTION WITH RECOMBINANT ADENO-ASSOCIATED VIRUS FOR GENE THERAPY IS LIMITED BY LEADING-STRAND SYNTHESIS", JOURNAL OF VIROLOGY,US,THE AMERICAN SOCIETY FOR MICROBIOLOGY, vol. 70, no. 1, pages 520-532, XP000570468, ISSN: 0022-538X *
LEPPARD K. N.: "E4 gene function in adenovirus, adenovirus vector and adenovirus infections", JOURNAL OF GENERAL VIROLOGY,GB,SOCIETY FOR GENERAL MICROBIOLOGY, READING, vol. 78, pages 2131-2138, XP002086863, ISSN: 0022-1317 *

Also Published As

Publication number Publication date
GB9811171D0 (en) 1998-07-22
WO1999061640A2 (fr) 1999-12-02

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WO1999061640A3 (fr) Vecteur derive par aav

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