WO1999049841A1 - Compositions pour soins de la peau - Google Patents

Compositions pour soins de la peau Download PDF

Info

Publication number
WO1999049841A1
WO1999049841A1 PCT/US1998/006243 US9806243W WO9949841A1 WO 1999049841 A1 WO1999049841 A1 WO 1999049841A1 US 9806243 W US9806243 W US 9806243W WO 9949841 A1 WO9949841 A1 WO 9949841A1
Authority
WO
WIPO (PCT)
Prior art keywords
skin
composition
skin care
water
glycol
Prior art date
Application number
PCT/US1998/006243
Other languages
English (en)
Inventor
Kiyoaki Mori
Chikako Inobe
Hidekazu Tanaka
Original Assignee
The Procter & Gamble Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Procter & Gamble Company filed Critical The Procter & Gamble Company
Priority to JP52618999A priority Critical patent/JP2002512638A/ja
Priority to AU67879/98A priority patent/AU6787998A/en
Priority to PCT/US1998/006243 priority patent/WO1999049841A1/fr
Publication of WO1999049841A1 publication Critical patent/WO1999049841A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Definitions

  • the present invention relates to a skin care composition.
  • it relates to a skin care composition for moisturizing the skin.
  • Extrinsic factors include ultraviolet radiation (e.g., from sun exposure), environmental pollution, wind, heat, low humidity, harsh surfactants, abrasives, and the like.
  • Intrinsic factors include chronological aging and other biochemical changes from within the skin. Whether extrinsic or intrinsic, these factors result in visible signs of skin aging and environmental damage such as wrinkling and other forms of roughness (including increased pore size, flaking and skin lines), and other histological changes associated with skin aging or damage. Signs of skin aging include, but are not limited to, all outward visibly and tactilely perceptible manifestations as well as any other macro or micro effects due to skin aging.
  • the skin is typically treated with a moisturizing agent.
  • moisturizing agents include, e.g., glycol or glycerin. Increasing the level of moisturizing agent applied to the skin typically provides improved moisturization of the skin.
  • compositions typically have a high water content. Additionally, consumers expect such high water content compositions to have a non-greasy feeling. Unfortunately, as the percentage of moisturizing agent is increased in such compositions, these compositions tend to impart a greasy feeling and result in poor distribution/spreading of the moisturizing agent to the skin.
  • the present invention is directed to a skin care composition having a moisturizing agent, a polyoxyalkylene glycol of 2 to about 3 carbons having an average molecular weight of from about 5,000 to about 500,000, a water-soluble polymeric thickening agent, a nonionic surfactant, and a carrier.
  • the total amount of surfactant in the composition is less than 5% of the composition.
  • topical application means to apply or spread the compositions onto the surface of the skin.
  • compositions or components thereof so described are suitable for use in contact with human skin without undue toxicity, incompatibility, instability, irritation allergic response, and the like, commensurate with a reasonable benefit/risk ratio.
  • cosmetically-acceptable carrier means one or more compatible dermatologically-acceptable solid or liquid filler diluents or encapsulating substances.
  • safety and effective amount means an amount of a compound or composition sufficient to significantly induce a positive benefit, preferably a positive skin appearance or feel benefit, including independently the benefits disclosed herein, but low enough to avoid serious side effects, i.e., to provide a reasonable benefit to risk ratio, within the scope of sound judgment of the skilled artisan.
  • the composition of the present invention includes a moisturizing agent, a polyoxyalkylene glycol, a thickening agent, a nonionic surfactant, and a carrier.
  • the composition is a dermatologically-acceptable topical composition; more preferably a cosmetic composition.
  • composition of the present invention contains a safe and effective amount of a moisturizing agent.
  • the moisturizing agent is hydrophilic and has a high water holding capacity.
  • water holding capacity means components and/or materials which facilitate water/moisture retention in the skin.
  • the moisturizing agent useful herein includes any component which can be typically formulated into skin lotions as a moisturizer and/or humectant.
  • the moisturizing agent useful herein is selected from polyhydric alcohols; glycolic acid and glycolate salts; lactic acid and lactate salts (e.g. sodium lactate); aloe vera in any of its variety of forms (e.g., aloe vera gel); sugar and starch derivatives (e.g., alkoxylated glucose); amino acid and derivatives thereof; amides (e.g., urea); alkanolamides (e.g., lactamide monoethanolamine; acetamide monoethanolamine); and mixtures thereof; preferably polyhydric alcohols, lactic acid and lactate salts, or amides.
  • polyhydric alcohols e.g. sodium lactate
  • aloe vera in any of its variety of forms
  • sugar and starch derivatives e.g., alkoxylated glucose
  • amino acid and derivatives thereof amides (e.g., urea); alkanolamides (e.g., lactamide monoethanolamine; acetamide
  • Preferred polyhydric alcohols useful herein include, but are not limited to, polyalkylene glycols, more preferably alkylene polyols and their derivatives including glycerin, propylene glycol, dipropylene glycol, tripropylene glycol, polyethylene glycol and derivatives thereof, sorbitol, hydroxypropyl sorbitol, erythritol, threitol, pentaerythritol, xylitol, glucitol, mannitol, hexylene glycol, 1 ,3- butylene glycol, 1 ,2,6-hexanetriol, glycerol, ethoxylated glycerol, propoxylated glycerol, sodium 2-pyrrolidone-5-carboxylate, soluble collagen, gelatin, and mixtures thereof.
  • polyalkylene glycols more preferably alkylene polyols and their derivatives including glycerin, propy
  • Preferred moisturizing agents are glycerin, 1 ,3-butylene glycol, glucose, lactic acid, trimethylglycine, urea, or mixtures thereof; more preferably glycerin, trimethylglycine, or urea.
  • the composition of the present invention preferably contains from about
  • the composition of the present invention includes a polyoxyalkylene glycol; preferably a 2 to about 3 carbon-containing polyoxyalkylene glycol.
  • the polyoxyalkylene glycol useful herein has an average molecular weight (hereinafter "M.W.") of from about 5,000 to about 500,000, more preferably from about 10,000 to about 300,000. It is believed that the polyoxyalkylene glycol can also provide moisturization of the skin, but without imparting the greasy feeling typically resulting from relatively high levels of moisturizing agent. Consequently, the composition containing these specific polyethylene glycols can decrease the concentration of moisturizing agent, thereby providing a composition having improved moisturization without any greasy feeling of the skin.
  • M.W. average molecular weight
  • the polyoxyalkylene glycol useful herein includes polyoxyethylene glycol, polyoxypropylene glycol, block copolymers of polyoxyethylene glycol and polyoxypropylene glycol, and mixtures thereof.
  • a preferred polyoxyalkylene glycol is a combination of two or more polyethylene glycols having a lower average M.W. (i.e., about 20,000) and a higher average M.W (e.g., from about 150,000 to about 200,000).
  • the composition has from about 0.1% to about 3% of polyoxyalkylene glycol; more preferably from about 0.5% to about 1 %.
  • composition of the present invention includes a water-soluble polymeric thickening agent.
  • the water-soluble polymeric thickening agent is present from about 0.0001% to about 0.15%, more preferably from about 0.001% to about 0.1 % in the skin care composition.
  • the water-soluble polymeric thickening agent in combination with the polyethylene glycol can facilitate the spreadability of the composition onto the skin. It is also believed that a higher level (i.e., greater than about 0.15%) of the water-soluble polymeric thickening agent in the composition will result in an undesirably tacky feeling composition. It further is believed a lower concentration of the water soluble polymeric thickening agent (i.e., less than about 0.0001%) may result in insufficient moisturization of the skin.
  • Water-soluble polymeric thickening agents useful herein include polysaccharides, gums, mucopolysaccharides (e.g., hyaluronic acid, chondroitin sulfate), carboxylic acid polymers, crosslinked polyacrylate polymers, and mixtures thereof; preferably polysaccharides, gums, or mixtures thereof.
  • Extract materials which are derived from natural sources can be included as water-soluble polymeric thickening agent.
  • Quince Seed is available from Taiyo Kagaku (Mie prefecture, Japan). 1. Polvsaccharide,
  • polysaccharides refers to thickening agents containing a backbone of repeating sugar (e.g., carbohydrate) units.
  • useful polysaccharides include those selected from the group consisting of cellulose, carboxymethyl hydroxyethylcellulose, hydroxyethylcellulose, hydroxyethyl ethylcellulose, hydroxypropylcellulose, hydroxypropyl methylcellulose, methyl hydroxyethylcellulose, microcrystalline cellulose, sodium cellulose sulfate, and mixtures thereof; more preferably hydroxypropylcellulose.
  • the hydroxy groups of the cellulose polymer are preferably hydroxyalkylated (preferably hydroxyethylate or hydroxypropylate), forming a hydroxyalkylated cellulose that is further modified with a straight or branched alkyl group of from about 10 to about 30 carbons through an ether linkage.
  • Preferred polysaccharides are ethers of straight or branched alcohols of from about 10 to about 30 carbons with hydroxyalkylcelluloses.
  • alkyl substituted cellulose examples include alkyl substituted cellulose.
  • alkyl groups useful herein include stearyl, isostearyl, lauryl, myristyl, cetyl, isocetyl, cocoyl (e.g., alkyl groups derived from the alcohols of coconut oil), palmityl, oleyl, linoleyl, linolenyl, ricinoleyl, behenyl, and mixtures thereof.
  • Preferred among the alkyl hydroxyalkyl cellulose ethers herein is the material given the CTFA designation cetyl hydroxyethylcellulose, which is the ether of cetyl alcohol and hydroxyethylcellulose. This material is sold under the tradename Natrosol® CS Plus from Aqualon Corporation (Willmington, U.S.A.).
  • polysaccharides useful herein include scleroglucans containing a linear chain of (1 to less than 3) linked glucose units with a (1 to less than 6) linked glucose every three units.
  • scleroglucans containing a linear chain of (1 to less than 3) linked glucose units with a (1 to less than 6) linked glucose every three units.
  • ClearogelTM CS11 from Michel Mercier Products Inc. (Mountainside, NJ, U.S. A.).
  • water-soluble polymeric thickening agents which can be employed in the composition of the present invention include materials which are primarily derived from natural sources.
  • Nonlimiting examples of such water-soluble polymeric thickening agents include gums selected from the group consisting of acacia, agar, algin, alginic acid, ammonium alginate, amylopectin, calcium alginate, calcium carrageenan, carnitine, carrageenan, dextrin, gelatin, gellan gum, guar gum, guar hydroxypropyltrimonium chloride, sodium hyaluroinate, hydroxypropyl chitosan, hydroxypropyl guar, karaya gum, kelp, locust bean gum, natto gum, potassium alginate, potassium carrageenan, propylene glycol alginate, sclerotium gum, sodium carboxymethyl dextran, sodium carrageenan, tragacanth gum, xanthan gum, and mixtures thereof.
  • Additional thickening gelling agents which are suitable herein as water- soluble polymeric thickening agents include those disclosed in U.S. Patent No., 4,387,107, to Klein et al., issued June 7, 1983 and "Encyclopedia of Polymer and Thickeners for Cosmetics," R.Y. Lochhead and W. R. Fron, eds., Cosmetics & Toiletries, vol. 108, pp. 95-135 (May 1993).
  • P. Nonionic Surfactant are those disclosed in U.S. Patent No., 4,387,107, to Klein et al., issued June 7, 1983 and "Encyclopedia of Polymer and Thickeners for Cosmetics," R.Y. Lochhead and W. R. Fron, eds., Cosmetics & Toiletries, vol. 108, pp. 95-135 (May 1993).
  • composition of the present invention contains a nonionic surfactant.
  • a nonionic surfactant facilitates absorption and/or penetration of any actives (e.g., moisturizing agents, any additional ingredients such as Vitamin C, etc.) into the skin.
  • composition of the present invention contains from about 0.1 % to about 2%, more preferably from about 0.2% to about 1 % of the nonionic surfactant.
  • Nonionic surfactants useful herein preferably include those that can be broadly defined as condensation products of long chain alcohols, (e.g. alcohols of from about 8 to about 30 carbons), with sugar or starch polymers (e.g., glycosides).
  • S is a sugar moiety such as glucose, fructose, mannose, and galactose
  • R is an alkyl of from about 8 to about 30 carbons
  • n is an integer of from about 1 to about 1 ,000.
  • alcohols having a long carbon chain from which the alkyl can be derived include decyl alcohol, cetyl alcohol, stearyl alcohol, lauryl alcohol, myristyl alcohol, oleyl alcohol, and the like.
  • Preferred nonionic surfactants herein include those wherein S is a glucose moiety; R is an alkyl of from about 8 to about 20 carbons; and n is an integer of from about 1 to about 9.
  • surfactants include decyl polyglucoside, available as APG ® 325 CS from Henkel (Ambler, PA, U.S.A.) and lauryl polyglucoside, available as APG ® 600 CS and 625 CS from Henkel (Ambler, PA, U.S.A.).
  • nonionic surfactants useful herein include the condensation products of alkylene oxides with fatty acids (e.g., alkylene oxide esters of fatty acids).
  • R ⁇ CO( ⁇ 1) m OH wherein R1 is an alkyl of from about 10 to about 30 carbons; X 1 is -OCH2CH2- derived from, for example ethylene glycol or oxide or -OCH2CHCH3- derived from, for example propylene glycol or oxide; and m is an integer from about 6 to about 200.
  • R 2 CO(X 2 ) p OOCR 2 wherein R 2 is independently an alkyl of from about 10 to about 30 carbons; X 2 is - OCH2CH2- derived from, for example ethylene glycol or oxide or -OCH2CHCH3- derived from, for example propylene glycol or oxide; and p is an integer from about 6 to about 100.
  • Nonionic surfactants are the condensation products of alkylene oxides with fatty alcohols (e.g., alkylene oxide ethers of fatty alcohols). These materials have the general formula R 3 (X 3 ) q OR 4 wherein R 3 and R 4 are independently H or alkyl of from about 10 to about 30 carbons; X 3 is -OCH2CH2- derived from, for example ethylene glycol or oxide or -OCH2CHCH3- derived from, for example propylene glycol or oxide; and q is an integer from about 6 to about 100.
  • nonionic surfactants useful herein are the condensation products of alkylene oxides with both fatty acids and fatty alcohols (e.g., wherein the polyalkylene oxide portion is esterified on one end with a fatty acid and etherified (e.g., connected via an ether linkage) on the other end with a fatty alcohol).
  • These materials have the general formula R 5 CO(X 4 ) Z OR6 wherein R5 and R ⁇ are independently alkyl of from about 10 to about 30 carbons; X 4 is -OCH2CH2 derived from, for example ethylene glycol or oxide or -OCH2CHCH3- derived from propylene glycol or oxide; and z is an integer from about 6 to about 100.
  • Nonlimiting examples of such alkylene oxide derived nonionic surfactants include ceteth-6, ceteth-10, ceteth-12, ceteareth-6, ceteareth-10, ceteareth-12, ceteareth-20, steareth-6, steareth-10, steareth-12, steareth-20, PEG-100 steareth, PEG-6 stearate, PEG-10 stearate, PEG-12 stearate, PEG-100 stearate, PEG-10 glyceryl stearate, PEG-20 glyceryl stearate, PEG-30 glyceryl cocoate, PEG-80 glyceryl cocoate, PEG-80 glyceryl tallowate, PEG-200 glyceryl tallowate, PEG-8 dilaurate, PEG-10 distearate, and mixtures thereof.
  • nonionic surfactants suitable herein include sugar esters and polyesters, alkoxylated sugar esters and polyesters, C1-C30 fatty acid esters of C1-C30 fatty alcohols, alkoxylated derivatives of C1-C30 fatty acid esters of C1- C30 fatty alcohols, alkoxylated ethers of C1-C30 fatty alcohols, polyglyceryl esters of C1-C30 fatty acids, C1-C30 esters of polyols, C1-C30 ethers of polyols, alkyl phosphates, polyoxyalkylene fatty ether phosphates, fatty acid amides, acyl lactylates, and mixtures thereof.
  • Nonlimiting examples of these nonionic surfactants include: polyethylene glycol 20 sorbitan monolaurate (Polysorbate 20), polyethylene glycol 20 sorbitan monostearate (Polysorbate 60), polyethylene glycol 20 sorbitan monooleate (Polysorbate 80), polyethylene 20 sorbitan trioleate (Polysorbate 85), polyethylene glycol 5 soya sterol, PPG-2 methyl glucose ether distearate, cetyl phosphate, potassium cetyl phosphate, diethanolamine cetyl phosphate, glyceryl stearate, polyoxyethylene 4 lauryl ether sodium stearate, polyglyceryl-4 isostearate, and mixtures thereof.
  • PPG-2 methyl glucose ether distearate cetyl phosphate
  • cetyl phosphate potassium cetyl phosphate
  • diethanolamine cetyl phosphate diethanolamine cetyl phosphate
  • glyceryl stearate polyoxyethylene 4 lauryl
  • composition of the present invention further contains a water-based carrier
  • the carrier also acts as a solvent for one or more of the other components of the composition.
  • the carrier is a dermatologically-acceptable carrier; more preferably a cosmetically-acceptable carrier.
  • the carrier is a water, alcohol, or mixtures thereof; more preferably water.
  • the carrier includes water in combination with: lower alkyl alcohols, polyhydric alcohols, and mixtures thereof.
  • Lower alkyl alcohols useful herein are C ⁇ -CQ alkyl monohydric alcohols, preferably C2-C3 alkyl alcohols.
  • Preferred lower alkyl alcohols include ethyl alcohol, isopropyl alcohol, and mixtures thereof.
  • Polyhydric alcohols useful herein include propylene glycol, hexylene glycol, glycerin, and propane diol, and mixture thereof.
  • composition of the present invention contains from about 80% to about 95.0% of the carrier.
  • composition of the present invention can further include a wide variety of additional dermatologically-acceptable ingredients.
  • the level and species of the additional ingredients are selected according to the compatibility with other components, and desired characteristic of the composition and/or forms of the composition.
  • Additional ingredients can include aesthetic agents and active agents. Such additional ingredients useful herein should be physically and chemically compatible with the essential components described herein, and not unduly impair stability, efficacy or other use benefits associated with the skin care composition of the present invention. Additional ingredients may be dispersed, dissolved or the like in any liquid materials described herein which can be employed as a carrier.
  • a pH adjusting agent can be present as an additional ingredient.
  • the pH adjusting agent tends to prevent decomposition of the ingredients leading to 10
  • Suitable pH adjusting agents herein include acetate, phosphate, citrate, triethanolamine, lactate, and carbonate, preferably lactate.
  • a combination of foregoing agents may be employed to provide a specific optimized pH for the composition.
  • the total level of pH adjusting agent in the composition is from about 0.01% to about 5%, more preferably from about 0.5% to about 2%.
  • the skin care composition may include absorbents (including oil absorbents such as clays and polymeric absorbents), abrasives, anticaking agents, antifoaming agents, antimicrobial agents (e.g., a compound capable of destroying microbes, preventing the development of microbes or preventing the pathogenic action of microbes and useful, for example, in controlling acne and/or preserving the topical composition such as IrgasanTM DP 300 (Ciba Geigy Corp., U.S.A.) and phenoxyethanol, binders, biological additives, bulking agents, chemical additives, skin care biocides, denaturants, skin care astringents, drug astringents, external analgesics, film formers, fragrances and/or perfumes, colorings, essential oils, skin
  • absorbents including oil absorbents such as clays and polymeric absorbents
  • abrasives anticaking agents
  • antifoaming agents e.g., a compound capable of
  • compositions of the present invention are generally prepared by any method conventionally used for providing skin care compositions, particularly for skin lotions, that are known in the art. Such methods typically involve mixing of the ingredients in one or more steps to a relatively uniform state, with or without heating, cooling, and the like. Typical methods are described in, for example are described in Harry's Cosmeticology, 7 th Ed., Harry & Wilkinson (Hill Publishers, London 1982). H. Method for Moisturizing Skin
  • compositions of the present invention are useful for moisturizing the skin, particularly for mammalian skin (especially human skin, more especially human facial skin). Moisturization of the skin is obtained by topically applying to the skin a safe and effective amount of the composition of the present invention.
  • compositions of the present invention can be employed to provide a desirable skin appearance and/or feel benefit.
  • Quantities of the present composition which are typically applied per application are, in mg composition/cm 2 skin, from about 0.1 mg/cm 2 to about 10 mg/cm 2 .
  • a particularly useful application amount is about 2 mg/cm 2 .
  • Moisturizing the skin is generally practiced by applying the composition in the form of a skin lotion, cream, skin care, or the like. These are intended to be left on the skin for some aesthetic, prophylactic, therapeutic or other benefit (e.g., a "leave-on" composition).
  • composition of the present invention preferably has a Hydration Factor of from about 5 to about 17; more preferably from about 6.5 to about 15. 12
  • SMHT Skin Moisturizer Hydration Test
  • the SMHT evaluates and compares in vivo the hydration efficacy of topical compositions.
  • the method of SMHT utilizes a ComeometerTM 820 PC (supplied by Courage and Khazaka; (Kairn, Germany) to measure the electrical capacitance of the skin surface. Without being limited by theory, it is believed that the electrical capacitance of the skin is an indirect measurement of water presence and therefore skin surface hydration.
  • the SMHT is determined by at least 16 subjects in general good health (free of medical conditions, adverse reactions or sensitivities which might affect the skin test results).
  • the products to be tested are applied to the forearms of each subject, in an area not having excessive amounts of hair, dermatitis or scars. More specifically, at least two, 3x4 cm 2 , test regions are identified on the valor region of the same forearm.
  • hydration measurements on treated sites will be baseline subtracted.
  • a multi-factor analysis of variance using Fischer's least significant difference analysis should be applied to compare data between products.
  • a comparatively higher Comeometer value reading indicates higher skin surface capacitance and therefore higher skin surface water content or hydration.
  • Examples 1 - 5 of the composition of the present invention are prepared from the following ingredients by the formulating techniques set forth below.
  • Tween 20 polyethylene glycol 20 sorbitan monolaurate named Polysorbate 20 in CTFA
  • Tween 60 polyethylene glycol 60 sorbitan monostearete named Polysorbate 60 in CTFA
  • Examples 6 - 7 of composition of the present invention are prepared from the following ingredients by the formulating techniques set forth below.
  • Tween 20 polyethylene glycol 20 sorbitan monolaurate as CTFA named Polysorbate 20 Quince Seed: Quince Extra, powder of dried seeds of Cydonia oblonga
  • CarbomerTM (Ohio, U.S.A.): homopolymer of acrylic acid crosslinked with allyl ether of pentaerythritol or sucrose propylene 16
  • the embodiments disclosed and represented by the previous examples have many advantages. For example, they can provide improved moisturization of the skin without imparting a greasy feeling and/or provide good spreadability during use. It is believed high levels of the moisturizing agent contributes to a greasy feeling. However, it is further believed the polyoxyethylene gylcol also provides significant moisturization, without imparting a greasy feeling. Consequently, by including polyoxyethylene glycol in the composition, the levels of the moisturizing agent versus known compositions can be reduced, yet similar or improved moisturization can be obtained while also providing a non-greasy feeling. 17
  • the composition tends to undesirably reduce the spreadability of the composition.
  • the water- soluble polymeric thickening agent is generally believed to have spreadability itself.
  • the combination of water-soluble polymeric thickening agent and the polyoxyethylene glycol improves overall spreadability of the composition to the skin. Consequently, the improved spreadability can be achieved by combining the water-soluble polymeric thickening agent with the polyoxyethylene glycol.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne une composition pour soins de la peau présentant un agent hydratant, un polyoxyalkylène glycol ayant entre 2 et environ 3 carbones dont le poids moléculaire moyen est compris entre 5.000 et environ 500.000, un agent épaississant polymère hydrosoluble, un tensioactif non ionique et un support, la quantité totale de tensioactif dans la composition étant inférieure à 5 % de la composition.
PCT/US1998/006243 1998-03-30 1998-03-30 Compositions pour soins de la peau WO1999049841A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP52618999A JP2002512638A (ja) 1998-03-30 1998-03-30 スキンケア組成物
AU67879/98A AU6787998A (en) 1998-03-30 1998-03-30 Skin care compositions
PCT/US1998/006243 WO1999049841A1 (fr) 1998-03-30 1998-03-30 Compositions pour soins de la peau

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1998/006243 WO1999049841A1 (fr) 1998-03-30 1998-03-30 Compositions pour soins de la peau

Publications (1)

Publication Number Publication Date
WO1999049841A1 true WO1999049841A1 (fr) 1999-10-07

Family

ID=22266713

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/006243 WO1999049841A1 (fr) 1998-03-30 1998-03-30 Compositions pour soins de la peau

Country Status (3)

Country Link
JP (1) JP2002512638A (fr)
AU (1) AU6787998A (fr)
WO (1) WO1999049841A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2859105A1 (fr) * 2003-09-02 2005-03-04 Vegeflore Composition pour le traitement ou la prevention du ronflement
US7001355B2 (en) 2002-01-21 2006-02-21 The Procter & Gamble Company Skin care device
US7618616B2 (en) 2001-04-25 2009-11-17 State of Israel Prime Minister's Office-Israel Institute of Biological Research Skin-protective compositions effective against vesicants and percutaneous chemical agents
WO2015180083A1 (fr) * 2014-05-29 2015-12-03 The Procter & Gamble Company Lotion tonique hydratante non grasse
EP2988830B1 (fr) 2013-04-25 2021-03-17 L'Oréal Composition de lissage des fibres kératiniques comprenant de l'urée et/ou un dérivé d'uréeet un polymère épaississant associatif non-ionique, cationique, amphotérique ou anionique, son procédé et son utilisation.
US11166885B2 (en) 2016-09-22 2021-11-09 Colgate-Palmolive Company Personal care gel and method
WO2023287690A1 (fr) * 2021-07-12 2023-01-19 Ocusoft, Inc. Compositions hydratantes pour la peau

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011070620A1 (fr) * 2009-12-10 2011-06-16 Kawakita Hiromi Cosmétique
JP6219029B2 (ja) * 2012-11-19 2017-10-25 ポーラ化成工業株式会社 Ｏ／ｗ／ｏ型乳化剤型の皮膚外用剤

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1948990A1 (de) * 1968-10-02 1970-05-27 Kolmar Laboratories Mittel zur oertlichen Behandlung der Haut
FR2649718A1 (fr) * 1989-07-17 1991-01-18 Int Research & Dev Co Ltd Formulation de gel nettoyant pour le visage
WO1992019216A1 (fr) * 1991-05-04 1992-11-12 The Procter & Gamble Company Compositions en gel pour le soin de la peau et des cheveux
WO1993016678A1 (fr) * 1992-02-28 1993-09-02 Wella Aktiengesellschaft Utilisation d'une preparation destinee a empecher des colorations de la peau lors de la teinture des cheveux, nouveaux agents de protection de la peau et procede de teinture des cheveux
WO1995033489A1 (fr) * 1994-06-07 1995-12-14 Allergan Composition de gel stable pour le traitement topique de maladies de la peau
EP0689767A2 (fr) * 1994-06-27 1996-01-03 Becton, Dickinson and Company Formulations désinfectantes pour la peau
WO1997025973A1 (fr) * 1996-01-12 1997-07-24 The Procter & Gamble Company Compositions traitantes pour les cheveux ou la peau

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1948990A1 (de) * 1968-10-02 1970-05-27 Kolmar Laboratories Mittel zur oertlichen Behandlung der Haut
FR2649718A1 (fr) * 1989-07-17 1991-01-18 Int Research & Dev Co Ltd Formulation de gel nettoyant pour le visage
WO1992019216A1 (fr) * 1991-05-04 1992-11-12 The Procter & Gamble Company Compositions en gel pour le soin de la peau et des cheveux
WO1993016678A1 (fr) * 1992-02-28 1993-09-02 Wella Aktiengesellschaft Utilisation d'une preparation destinee a empecher des colorations de la peau lors de la teinture des cheveux, nouveaux agents de protection de la peau et procede de teinture des cheveux
WO1995033489A1 (fr) * 1994-06-07 1995-12-14 Allergan Composition de gel stable pour le traitement topique de maladies de la peau
EP0689767A2 (fr) * 1994-06-27 1996-01-03 Becton, Dickinson and Company Formulations désinfectantes pour la peau
WO1997025973A1 (fr) * 1996-01-12 1997-07-24 The Procter & Gamble Company Compositions traitantes pour les cheveux ou la peau

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7618616B2 (en) 2001-04-25 2009-11-17 State of Israel Prime Minister's Office-Israel Institute of Biological Research Skin-protective compositions effective against vesicants and percutaneous chemical agents
US7001355B2 (en) 2002-01-21 2006-02-21 The Procter & Gamble Company Skin care device
FR2859105A1 (fr) * 2003-09-02 2005-03-04 Vegeflore Composition pour le traitement ou la prevention du ronflement
EP2988830B1 (fr) 2013-04-25 2021-03-17 L'Oréal Composition de lissage des fibres kératiniques comprenant de l'urée et/ou un dérivé d'uréeet un polymère épaississant associatif non-ionique, cationique, amphotérique ou anionique, son procédé et son utilisation.
WO2015180083A1 (fr) * 2014-05-29 2015-12-03 The Procter & Gamble Company Lotion tonique hydratante non grasse
US11166885B2 (en) 2016-09-22 2021-11-09 Colgate-Palmolive Company Personal care gel and method
WO2023287690A1 (fr) * 2021-07-12 2023-01-19 Ocusoft, Inc. Compositions hydratantes pour la peau
GB2625649A (en) * 2021-07-12 2024-06-26 Ocusoft Inc Skin moisturizing compositions

Also Published As

Publication number Publication date
JP2002512638A (ja) 2002-04-23
AU6787998A (en) 1999-10-18

Similar Documents

Publication Publication Date Title
EP1032363B1 (fr) Systeme d'apport d'acide linoleique conjugue dans des preparations cosmetiques
KR101964809B1 (ko) No 활성 억제제, 이를 포함하는 항염증 제제, 이를 포함하는 화장품 및 이의 제조방법
CN109010243A (zh) 一种保湿精华液
EP1178772B1 (fr) Micro-emulsion transparente
EP2029089B1 (fr) Émulsion h/e pour le soin de la main
CN108653112A (zh) 一种控油护肤组合物
WO1999049841A1 (fr) Compositions pour soins de la peau
CN104761651A (zh) 一种益母草多糖及其应用
CN110339102A (zh) 海藻提取物组合物及其在化妆品中的用途
CN109998942B (zh) 一种多效美白组合物及其制备方法
JP3172753B2 (ja) 生体ヒアルロン酸合成促進剤
EP1139975B1 (fr) Compositions transparentes de soins pour la peau
JP3534945B2 (ja) 皮膚化粧料
CN109939025A (zh) 一种对手脚皮肤干裂修复功能的润肤霜
JP3667376B2 (ja) ヒアルロニターゼ阻害剤
JP3479048B2 (ja) 化粧料及び不織布含浸化粧料
JP2002145753A (ja) 保湿用組成物及び該組成物を含有する化粧料
CN116940325A (zh) 用于调理角蛋白材料的组合物
WO2013030635A2 (fr) Compositions pour des périodes prolongées d'hydratation de la peau
JP2001278768A (ja) 皮膚外用剤
CN117482028B (zh) 一种长效保湿乳液及其制备方法
JP3615001B2 (ja) 皮膚化粧料
CN116942584B (zh) 一种含铁皮石斛和多肽的面膜及其制备方法
KR102652375B1 (ko) 마그네슘트라이펩타이드-1의 제조방법
JP2001072567A (ja) 皮膚化粧料

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM GW HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
NENP Non-entry into the national phase

Ref country code: KR

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: CA