WO2011070620A1 - Cosmétique - Google Patents

Cosmétique Download PDF

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Publication number
WO2011070620A1
WO2011070620A1 PCT/JP2009/006761 JP2009006761W WO2011070620A1 WO 2011070620 A1 WO2011070620 A1 WO 2011070620A1 JP 2009006761 W JP2009006761 W JP 2009006761W WO 2011070620 A1 WO2011070620 A1 WO 2011070620A1
Authority
WO
WIPO (PCT)
Prior art keywords
component
cosmetic
hyaluronic acid
skin
esters
Prior art date
Application number
PCT/JP2009/006761
Other languages
English (en)
Japanese (ja)
Inventor
川北裕美
宿利正康
井上吉二郎
Original Assignee
Kawakita Hiromi
Syukuri Masayasu
Inoue Kichijiro
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kawakita Hiromi, Syukuri Masayasu, Inoue Kichijiro filed Critical Kawakita Hiromi
Priority to JP2011544982A priority Critical patent/JP5680549B2/ja
Priority to PCT/JP2009/006761 priority patent/WO2011070620A1/fr
Publication of WO2011070620A1 publication Critical patent/WO2011070620A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

Definitions

  • the present invention relates to a cosmetic, and more particularly to a cosmetic in which a salt of hyaluronic acid is highly dispersed and solubilized without using water, that is, under non-aqueous conditions.
  • Examples of cosmetics containing hyaluronic acid salts include a skin external preparation disclosed in Patent Document 1.
  • hyaluronic acid salts are known to have extremely high hydrophilicity and high solubility in water. Further, as described above, since hyaluronic acid salts have a high water retention capacity, when water is dissolved as a solvent, the hyaluronic acid salts expand, that is, increase in volume. Therefore, when water containing hyaluronic acid salts contains water, it does not easily penetrate into the skin's stratum corneum even when the cosmetic is used, and it gives skin tension and elasticity. It was not possible to obtain a sufficient effect of reducing the above. Therefore, there has been a strong demand for cosmetics containing hyaluronic acid salts without using water, that is, under non-aqueous conditions.
  • the skin external preparation disclosed in Patent Document 1 contains phospholipids, glycol ethers and hyaluronic acid, hyaluronic acid derivatives or salts thereof, but without using water, that is, under non-aqueous conditions. It is not a skin external preparation (cosmetics) containing hyaluronic acid salts below.
  • the present invention has been made in view of the above circumstances, and an object of the present invention is a cosmetic in which hyaluronic acid salts are highly dispersed and solubilized without using water, that is, under non-aqueous conditions. Is to provide.
  • the present invention is a cosmetic comprising a liquid component A (polyhydric alcohols) as a solvent and a solid component B (hyaluronic acid salts) as a solute.
  • the cosmetic contains at least an A component (polyhydric alcohol) and a B component (hyaluronic acid salt) as essential components.
  • the cosmetic according to the present invention may contain esters as the C component in addition to the A component and the B component. Furthermore, the cosmetic according to the present invention may contain a nonionic surfactant in addition to the A component, the B component, and the C component. In addition, by adding the nonionic surfactant to the cosmetic, a hydrocarbon nonpolar solvent or a glycerin ester of a fatty acid can be further added.
  • the A component is preferably a diol-based glycol, and the C component is preferably a medium polar ester.
  • hyaluronic acid salts are highly dispersed and solubilized without using water, that is, under non-aqueous conditions.
  • Skin has a structure in which water is difficult to permeate because cells are composed of lipid membranes.
  • alcohols easily pass through the lipid membrane, they penetrate into the stratum corneum from the surface of the skin (skin).
  • the cosmetic according to the present invention contains hyaluronic acid salts and polyhydric alcohol as essential components, the hyaluronic acid salts penetrate into the stratum corneum and fix in the stratum corneum by the action of the alcohols as described above. Then, the hyaluronic acid salts take up the moisture of the skin, etc., and retain the moisture in the stratum corneum.
  • hyaluronic acid salts taken into the stratum corneum are easily adsorbed in deep wrinkles even within the stratum corneum. That is, the tension and moisture are generated from the inside of the skin (skin), and the wrinkles of the skin can be effectively reduced.
  • hyaluronic acid salts and polyhydric alcohols if the cosmetics contain esters and hydrocarbon nonpolar solvents, that is, if a lipophilic substance is contained in the cosmetics, hyaluronic acid In the skin (skin) surface easily penetrates into the stratum corneum.
  • the powder particles are uniformly dispersed, and the usability of the cosmetic is improved. The quality can be stabilized.
  • esters, nonionic surfactants, hydrocarbon nonpolar solvents, glycerin esters of fatty acids are appropriately blended, and It can improve the stretch and give a light touch.
  • FIG. 1 is a flowchart which is an example of the blending procedure of each component in the production example of the present invention.
  • the cosmetic according to the present invention comprises a polyhydric alcohol and a hyaluronic acid salt as essential components, that is, a cosmetic comprising a liquid polyhydric alcohol as a solvent and a solid hyaluronic acid salt as a solute. It is a fee.
  • hyaluronic acid salts can be highly dispersed and solubilized without using water, that is, under non-aqueous conditions. .
  • hyaluronic acid salts are blended as an essential component of the cosmetic according to the present invention for the purpose of skin beautifying effects such as skin gloss, firmness, moisture and moisture retention.
  • Specific examples of the hyaluronic acid salts include sodium hyaluronate and potassium hyaluronate.
  • the average molecular weight of the sodium hyaluronate is not particularly limited, but an average molecular weight of 3000 to 15000 is preferable.
  • dihydric alcohols particularly diol-based glycols are preferable.
  • examples of the polyhydric alcohols include a hydroxyl group and a carbonyl group, such as diacetone alcohol.
  • esters are oily ingredients blended as emollients (substances that soften the skin and stratum corneum) that give the skin flexibility. Specifically, the esters described above prevent evaporation of moisture that covers the skin, while retaining moisture inside the skin, providing moisture and flexibility to the skin, improving the spread of the cosmetic, It is blended to give the feel of it.
  • the esters are preferably those having a relatively low viscosity.
  • esters examples include linear and branched esters.
  • specific examples of the esters include medium-polar esters such as ethylhexyl palmitate, butyl lactate, propyl lactate, isopropyl myristate, and isopropyl palmitate.
  • the particularly polar esters are mentioned because polyhydric alcohols and hyaluronic acid salts, which are essential components of the cosmetics according to the present invention, are polar substances. This is for further promoting solubilization in a monohydric alcohol.
  • low polarity ester can also be mix
  • the esters may be polar esters in addition to medium polarity.
  • Polar esters are soluble in water and volatile. Therefore, it has the characteristics of lipophilic substances (penetration from the skin surface through the stratum corneum) and is also dry, so it is useful for eliminating the sticky feeling in summer, for example, and giving a light touch .
  • Specific examples include methyl lactate, lactate ethyl ester, and acetoacetic acid ethyl ester.
  • esters for example, monotriester produced by ester bonds with branched organic fatty acids and alcohols, such as isotridecyl isononanoate, isononyl isononanoate, hexadecyl isononanoate, oleates, etc.
  • blend with a material.
  • the cosmetic according to the present invention may contain a nonionic surfactant in addition to the essential components and the esters.
  • the nonionic surfactant is blended in order to have an excellent emulsifying power with respect to oil, to uniformly disperse powder particles, to improve usability and to stabilize quality.
  • Nonionic surfactants are classified into ester types, ether types, ester / ether types, and other types, and can be blended respectively.
  • a nonionic surfactant having an HLB (Hydrophile Lipophile Balance) value of 9 to 12, more preferably about 10 to 11, is preferable, for example, a derivative of sugar alcohol, more specifically, sorbes tetraoleate- 30 etc. are suitable.
  • HLB Hydrophile Balance
  • a hydrocarbon nonpolar solvent a glycerin ester of a fatty acid, and the like described below may be appropriately blended in the cosmetic.
  • the hydrocarbon-based nonpolar solvent is an oily component blended to moisturize the skin and to adjust the feel of the cosmetic.
  • the hydrocarbon nonpolar solvent include squalane, liquid paraffin, hydrogenated polyisobutene, ligroin, petroleum ether, and the like.
  • blend the said hydrocarbon type nonpolar solvent with the said cosmetics with the said nonionic surfactant it is preferable to mix
  • esters for example, glycerin esters of fatty acids may be added to the cosmetic.
  • the glycerin esters of fatty acids are oil components that are blended to moisturize the skin.
  • Specific examples of the glycerin esters of fatty acids include, for example, semi-synthetic triglycerides such as triethylhexanoin, triethyl citrate, (caprylic acid / capric acid) glyceryl, glyceryl tricaprate, and glyceryl tricaprylate. Can do.
  • glycerin esters of fatty acids include natural waxes, plant triglycerides, beeswax, carnauba wax, jojoba seed oil, olive oil, coconut oil, and the like.
  • a penetration enhancer may be added to the cosmetic in order to efficiently penetrate each component of the cosmetic into the skin (skin), that is, to promote penetration into the skin (skin).
  • Specific examples of the penetration enhancer include, for example, branched alcohols, more specifically benzyl alcohol, octyldodecanol, and isostearyl alcohol.
  • alkalis and acids may be added to the cosmetics as pH adjusters, and pigments and fragrances may be appropriately blended as necessary. Good.
  • step 1 1,3-butylene glycol is first put in a suitable container so that the ratio shown in Table 1 is included in the total cosmetic.
  • step 2 1,3-butylene glycol placed in the container is stirred.
  • step 3 sodium hyaluronate is added little by little to the container at the rate shown in Table 1.
  • step 4 1,3-butylene glycol and sodium hyaluronate placed in the container are stirred.
  • the number of rotations of stirring in the step 2 and the step 4 is relatively high. That is, by stirring at a high speed, the temperature of each component (solution in the container) placed in the container rises, and dispersion of each component can be promoted.
  • step 5 ethylhexyl palmitate is added to the container at the rate shown in Table 1. Then, in the next step 6, 1,3-butylene glycol, sodium hyaluronate and ethylhexyl palmitate that are put in the container are stirred.
  • lipophilic silicon such as dimethylsilylated silica may be appropriately blended.
  • Step 7 to Step 13 ethyl hexyl palmitate, solves-30 tetraoleate, isotridecyl isononanoate, squalane, isononyl isononanoate, triethylhexanoin, jojoba seed oil are sequentially added.
  • steps 7 to 13 shown in FIG. 1 are merely examples, and the order of addition to the container is not limited to the order of steps 7 to 13 shown in FIG.
  • a stirrer suitable for pulverization of particles is preferable, and in particular, a disper having a turbine-type rotor blade attached to the tip of a rotating rod or A homogenizer is preferred.
  • the rotational speed of the agitator is preferably about 6000 rpm to 10,000 rpm.
  • the cosmetic composition according to the present invention is suitable for a cosmetic composition that produces tension and moisture from the inside of the skin (skin) and can effectively reduce wrinkles on the skin.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Cosmetics (AREA)

Abstract

La présente invention a pour objet un cosmétique comprenant un composant liquide (A) (un polyol) en tant que solvant et un composant solide (B) (un sel d'acide hyaluronique) en tant que soluté, c'est-à-dire un cosmétique comprenant au moins le composant (A) (un polyol) et le composé (B) (un sel d'acide hyaluronique) en tant que composants essentiels. Le cosmétique peut comprendre en outre un ester en tant que composant (C) en plus des composants (A) et (B), et peut comprendre en outre un agent tensioactif non ionique en plus des composants (A), (B) et (C). Lorsque l'agent tensioactif non ionique est contenu dans le cosmétique, un solvant hydrocarboné non polaire et un ester de glycérine et d'acide gras peuvent être ajoutés au cosmétique.
PCT/JP2009/006761 2009-12-10 2009-12-10 Cosmétique WO2011070620A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2011544982A JP5680549B2 (ja) 2009-12-10 2009-12-10 化粧料
PCT/JP2009/006761 WO2011070620A1 (fr) 2009-12-10 2009-12-10 Cosmétique

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2009/006761 WO2011070620A1 (fr) 2009-12-10 2009-12-10 Cosmétique

Publications (1)

Publication Number Publication Date
WO2011070620A1 true WO2011070620A1 (fr) 2011-06-16

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PCT/JP2009/006761 WO2011070620A1 (fr) 2009-12-10 2009-12-10 Cosmétique

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JP (1) JP5680549B2 (fr)
WO (1) WO2011070620A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012153466A1 (fr) * 2011-05-10 2012-11-15 Sugawara Yukako Solution cosmétique, procédé de production d'une solution cosmétique, et procédé cosmétique
WO2015104484A1 (fr) 2014-01-10 2015-07-16 Cosmo International Ingredients Extrait végétal comprenant des sucrose-esters en tant que principe actif pour son utilisation dans une composition cosmétique, dermatologique ou nutracosmétique

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06287107A (ja) * 1993-03-31 1994-10-11 Sunstar Inc ゲル状乳化化粧料
JP2002512638A (ja) * 1998-03-30 2002-04-23 ザ、プロクター、エンド、ギャンブル、カンパニー スキンケア組成物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06287107A (ja) * 1993-03-31 1994-10-11 Sunstar Inc ゲル状乳化化粧料
JP2002512638A (ja) * 1998-03-30 2002-04-23 ザ、プロクター、エンド、ギャンブル、カンパニー スキンケア組成物

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HIROYUKI KANOKOGI ET AL.: "Saikin no Hoshitsu Kenkyu to Hoshitsuzai no Kaihatsu Doko -Hoshitsuzai Kaihatsu no Rekishi o Fumaete", FRAGRANCE JOURNAL, vol. 33, no. 10, 15 October 2005 (2005-10-15), pages 14 - 19 *
SEIJI NISHIYAMA: "Keshohin ni Okeru Mizu no Yakuwari", FRAGRANCE JOURNAL, vol. 21, no. 8, 15 August 1993 (1993-08-15), pages 51 - 57 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012153466A1 (fr) * 2011-05-10 2012-11-15 Sugawara Yukako Solution cosmétique, procédé de production d'une solution cosmétique, et procédé cosmétique
JP2012250970A (ja) * 2011-05-10 2012-12-20 Yukako Sugawara 化粧液，化粧液の製造方法及び化粧方法
US9439839B2 (en) 2011-05-10 2016-09-13 Yukako Sugawara Cosmetic solution, method for producing cosmetic solution, and cosmetic method
WO2015104484A1 (fr) 2014-01-10 2015-07-16 Cosmo International Ingredients Extrait végétal comprenant des sucrose-esters en tant que principe actif pour son utilisation dans une composition cosmétique, dermatologique ou nutracosmétique

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JP5680549B2 (ja) 2015-03-04

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