WO1999013855A1 - Composition for cosmetic or dermopharmaceutical use containing a combination of algae extract and exopolysaccharides - Google Patents

Composition for cosmetic or dermopharmaceutical use containing a combination of algae extract and exopolysaccharides Download PDF

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Publication number
WO1999013855A1
WO1999013855A1 PCT/FR1998/001831 FR9801831W WO9913855A1 WO 1999013855 A1 WO1999013855 A1 WO 1999013855A1 FR 9801831 W FR9801831 W FR 9801831W WO 9913855 A1 WO9913855 A1 WO 9913855A1
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cosmetic
extracts
haematococcus pluvialis
skin
combination
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PCT/FR1998/001831
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French (fr)
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Karl Lintner
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Sederma S.A.
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Priority to AU90778/98A priority Critical patent/AU9077898A/en
Publication of WO1999013855A1 publication Critical patent/WO1999013855A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/02—Algae
    • A61K36/05—Chlorophycota or chlorophyta (green algae), e.g. Chlorella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9706—Algae
    • A61K8/9722—Chlorophycota or Chlorophyta [green algae], e.g. Chlorella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/006—Antidandruff preparations

Definitions

  • compositions for cosmetic or dermopharmaceutical use containing a combination of seaweed extract and arid exopolysacch.
  • the object of the present invention is the discovery that the extract of a microalga called Haematococcus pluvialis has beneficial activities for the skin, and that the association with a polysaccharide of microbial origin is particularly effective in moisturizing cosmetic products and nutritious.
  • microalga Haematococcus pluvialis only grows in very specific regions of the globe, in particular in fresh, pure, unpolluted, very sunny waters. Rich in trace elements and vitamins, proteins and carbohydrates, it has energizing, regenerative and stimulating properties through oral absorption. We have discovered that extracts from this alga also have beneficial effects topically.
  • the patent FR 2688222 describes the obtaining of an oligo- or polysaccharide of glucuronic composition from the microorganism Rhizobium meliloti and the use of the gelling properties of these molecules in different fields, including that of cosmetics.
  • the formation of these gels nevertheless requires the presence of mono- or divalent cations, and the gels thus obtained are not well suited to galenical cosmetic requirements: they are rather compact, heat-sensitive and brittle.
  • the discovery object of the present invention is the fact that the cosmetic use of extracts of Haematococcus pluvialis improves the surface state of the skin and that the use of oligo- and polymers of glucuronic acid at a sufficiently low concentration which avoids gelation, makes it possible to form a film of only a few molecular layers on the skin: by associating the extract of microalgae ⁇ aematococcus pluvialis with glucuronic polysaccharides within a cosmetic composition, better hydration and cell regeneration results are obtained. skin with extract of Haematococcus pluvialis alone.
  • Example No. 1 Obtaining a mixture of polysaccharide and algae extract:
  • the selected Rhizobium meliloti strain, in particular Rhizobium meliloti NCIMB 40472 is cultivated on a medium containing sucrose, yeast extract and phosphoric salts of potassium, magnesium and sodium for 48 hours, at 30 ° C and pH 7.
  • the filtrate After elimination of the microorganisms by tangential filtration, the filtrate is preserved by suitable antimicrobial substances.
  • an extract of Haematococcus pluvialis is prepared by macerating the lyophilized or atomized microalgae in an aqueous or hydroglycolic excipient, followed by filtration, clarification, discoloration, possibly preservation.
  • the advantage of the extracts of this microalga lies in a favorable ratio of biological activity on dry matter (and associated color), which is often problematic in cosmetic phytotherapy.
  • the extracts are stable, odorless and easily used in all types of cosmetic products.
  • the extraction solvents for the preparation of the extracts which are the subject of this patent can be chosen from water, propylene glycol, butylene glycol, glycerin, polyethylene glycol, methyl or ethyl ethers of digiycols, cyclic polyols, ethoxylated or propoxylated diglycols or any mixture of these solvents.
  • the extracts can be obtained by maceration of the plant in the extraction solvent, for a more or less long period.
  • countercurrent techniques can be used, decoction, leaching, extraction using ultrasound, microwaves.
  • a dry extract from the liquid extract This can be achieved by conventional precipitation, drying, evaporation, atomization or lyophilization techniques.
  • the final composition intended for use in a cosmetic or dermopharmaceutical product consists of a mixture of the filtrate containing the polysaccharide and the algae extract, in a proportion of approximately 10: 1.
  • the mixing proportions of the bacterial filtrate with the Haematococcus pluvialis extract can vary from 1: 1 to 1000: 1, the culture conditions of Rhizobium meliloti can vary within reasonable limits and compatible with the metabolism of Rhizobium meliloti (pH 4 -8, temperature 20-40 ° C, sugar composition: glucose, fructose, sucrose, synthetic culture medium or one containing peptones, vitamin additives, etc.).
  • Example No. 2 Cosmetic Effectiveness A cosmetic gel was formulated containing 3% of the mixture of polysaccharide and extract of Haematococcus pluvialis. This gel was applied daily by a panel of 10 volunteers with dry and rough skin on the leg. On the other leg, a placebo gel was applied. A hydration study with the Cornéometer (measurement of the surface impedance) was carried out in parallel with a study of the corneocyte layers by scanning electron microscopy (SEM).
  • SEM scanning electron microscopy
  • the surface of the skin treated with the poiysaccharide / algae extract mixture is clearly more hydrated and less rough than the skin treated with placebo: the hydration values read by the corneometer increased by + 15%, SEM images show smoothing and better cell adhesion.
  • the extracts of Haematococcus pluvialis alone or in combination with the glucuronic polysaccharides which are the subject of the patent can be used in cosmetic and dermopharmaceutical products of all kinds.
  • Such compositions have moisturizing and nutritive activities for the skin.
  • the extracts of Haematococcus pluvialis alone or in combination with the glucuronic polysaccharides, subject of the patent can also find applications in all skin care including anti-aging, anti-wrinkle, anti-inflammatory, anti-radical, leather treatments haired
  • the extracts of Haematococcus pluvialis alone or in combination with the glucuronic polysaccharides which are the subject of this patent can be used in any galenic form used in cosmetics: O / W and W / O emulsion, milks, lotions, gels, ointments, body oils, hair lotions, shampoos, soaps, sticks and pencils, sprays, without this list being exhaustive.
  • the concentration of use of these extracts of Haematococcus pluvialis can vary between 0.01 and 90% (w / w), preferably between 0.5 and 10% in the finished product, in association with glucuronic polysaccharides it can vary between 0.001 and
  • the extracts of Haematococcus pluvialis alone or in combination with the glucuronic polysaccharides can be combined in the cosmetic compositions with any other ingredient usually used in cosmetics: extraction and or synthetic lipids, gelling and viscosifying polymers, surfactants and emulsifiers, hydro- or liposolubies active ingredients, extracts from other plants, tissue extracts, marine extracts.

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  • Dermatology (AREA)
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Abstract

The invention concerns compositions for cosmetic or dermopharmaceutical use containing a sufficient amount of an extract of the micro-algae Haematococcus pluvialis, preferably combined with an exopolysaccharide obtained from Rhizobium meliloti. The constituents have a synergetic action for skin nourishment, care and regeneration.

Description

Titre: Compositions à usage cosmétique ou dermopharmaceutique contenant une association d'extrait d'algue et d'exopolysacch aride.Title: Compositions for cosmetic or dermopharmaceutical use containing a combination of seaweed extract and arid exopolysacch.
Le maintien de la beauté, souplesse, santé de la peau humaine nécessite des soins. La recherche de l'Industrie cosmétique et dermopharmaceutique s'efforce de trouver les remèdes nécessaires aux maux auxquels la peau est exposée quotidiennement: irradiation solaire, pollution chimique, stress, vieiliissement génétique, déshydratation...Maintaining the beauty, suppleness, health of human skin requires care. Research in the cosmetic and dermopharmaceutical industry strives to find the remedies necessary for the ailments to which the skin is exposed daily: solar irradiation, chemical pollution, stress, genetic aging, dehydration ...
Un nombre toujours croissant de produits essaie de répondre aux besoins plus ou moins spécifiques des consommateurs. L'hydratation de l'épiderme et l'apport nutritif en vitamines et en micronutriments sont des domaines particulièrement étudiés par la recherche cosmétique.An ever-increasing number of products are trying to meet the more or less specific needs of consumers. The hydration of the epidermis and the nutritive supply of vitamins and micronutrients are areas particularly studied by cosmetic research.
Néanmoins, il reste un vaste champ libre pour découvrir des nouvelles solutions avantageuses pour nourrir et hydrater la peau.However, there is still a wide field to discover new beneficial solutions to nourish and hydrate the skin.
L'objet de la présente invention est la découverte que l'extrait d'une microalgue appelée Haematococcus pluvialis possède des activités bénéfiques pour la peau, et que l'association avec un polysaccharide d'origine microbienne est particulièrement efficace dans des produits cosmétiques hydratants et nutritifs.The object of the present invention is the discovery that the extract of a microalga called Haematococcus pluvialis has beneficial activities for the skin, and that the association with a polysaccharide of microbial origin is particularly effective in moisturizing cosmetic products and nutritious.
La microalgue Haematococcus pluvialis ne pousse que dans des régions bien spécifiques du globe, en particulier dans des eaux douces, pures, non polluées, bien ensoleillées. Riche en oligo-éléments et en vitamines, en protéines et carbohydrates, elle possède des vertus énergisantes, régénératrices et stimulantes par voie d'absorption orale. Nous avons découvert que les extraits de cette algue possèdent aussi des effets bénéfiques par voie topique.The microalga Haematococcus pluvialis only grows in very specific regions of the globe, in particular in fresh, pure, unpolluted, very sunny waters. Rich in trace elements and vitamins, proteins and carbohydrates, it has energizing, regenerative and stimulating properties through oral absorption. We have discovered that extracts from this alga also have beneficial effects topically.
Le problème de beaucoup de substances ou composants actifs utilisés en cosmétique réside néanmoins dans le fait que l'absorption au travers l'épiderme puisse être soit trop rapide, soit trop faible. Beaucoup de produits agissant soit en tant qu'aide à la pénétration, soit comme ralentissant l'effet « flash » d'une pénétration trop rapide, ont été découverts et proposés.The problem with many active substances or components used in cosmetics nevertheless lies in the fact that absorption through the epidermis can be either too rapid or too weak. Many products acting either as a penetration aid, or as slowing down the “flash” effect of too rapid penetration, have been discovered and offered.
Le brevet FR 2688222 décrit l'obtention d'un oligo- ou polysaccharide de composition glucuronique à partir du micro-organisme Rhizobium meliloti et l'utiiisation des propriétés gélifiantes de ces molécules dans différents domaines, y compris celui de la cosmétique.The patent FR 2688222 describes the obtaining of an oligo- or polysaccharide of glucuronic composition from the microorganism Rhizobium meliloti and the use of the gelling properties of these molecules in different fields, including that of cosmetics.
La formation de ces gels nécessite néanmoins la présence de cations mono- ou divalents, et les gels ainsi obtenus ne sont pas bien adaptés aux exigences galéniques cosmétiques: ils sont plutôt compacts, thermosensibles et cassants. La découverte objet de la présente invention est le fait que l'utilisation cosmétique des extraits d'Haematococcus pluvialis améliore l'état superficiel de la peau et que l'utilisation des oligo- et polymères d'acide glucuronique à une concentration suffisamment faible qui évite la gélification, permet de former un film de seulement quelques couches moléculaires sur la peau: en associant l'extrait de microalgues άΗaematococcus pluvialis aux polysaccharides glucuroniques au sein d'une composition cosmétique on obtient des meilleurs résultats d'hydratation et de régénération cellulaire de la peau qu'avec l'extrait d'Haematococcus pluvialis seul. Quelques exemples non limitatifs vont illustrer l'invention.The formation of these gels nevertheless requires the presence of mono- or divalent cations, and the gels thus obtained are not well suited to galenical cosmetic requirements: they are rather compact, heat-sensitive and brittle. The discovery object of the present invention is the fact that the cosmetic use of extracts of Haematococcus pluvialis improves the surface state of the skin and that the use of oligo- and polymers of glucuronic acid at a sufficiently low concentration which avoids gelation, makes it possible to form a film of only a few molecular layers on the skin: by associating the extract of microalgae άΗaematococcus pluvialis with glucuronic polysaccharides within a cosmetic composition, better hydration and cell regeneration results are obtained. skin with extract of Haematococcus pluvialis alone. Some nonlimiting examples will illustrate the invention.
Exemple n° 1 : Obtention du mélange de polysaccharide et d'extrait d'algue: La souche Rhizobium meliloti choisie, en particulier Rhizobium meliloti NCIMB 40472 est cultivée sur un milieu contenant du saccharose, de l'extrait de levure et des sels phosphoriques de potassium, de magnésium et de sodium pendant 48 heures, à 30°C et à pH 7.Example No. 1: Obtaining a mixture of polysaccharide and algae extract: The selected Rhizobium meliloti strain, in particular Rhizobium meliloti NCIMB 40472 is cultivated on a medium containing sucrose, yeast extract and phosphoric salts of potassium, magnesium and sodium for 48 hours, at 30 ° C and pH 7.
Après élimination des micro-organismes par filtration tangentielle, on conserve le filtrat par des substances antimicrobiennes appropriées.After elimination of the microorganisms by tangential filtration, the filtrate is preserved by suitable antimicrobial substances.
Par ailleurs, on prépare un extrait d'Haematococcus pluvialis en macérant les microalgues lyophilisées ou atomisées dans un excipient aqueux ou hydroglycoiique, suivie d'une filtration, clarification, décoloration, éventuellement conservation.In addition, an extract of Haematococcus pluvialis is prepared by macerating the lyophilized or atomized microalgae in an aqueous or hydroglycolic excipient, followed by filtration, clarification, discoloration, possibly preservation.
L'avantage des extraits de cette microalgue réside dans un ratio favorable d'activité biologique sur matière sèche (et couleur associée), ce qui est souvent problématique en phytothérapie cosmétique. Les extraits sont stables, sans forte odeur et facilement utilisés dans tous type de produit cosmétique.The advantage of the extracts of this microalga lies in a favorable ratio of biological activity on dry matter (and associated color), which is often problematic in cosmetic phytotherapy. The extracts are stable, odorless and easily used in all types of cosmetic products.
Les solvants d'extraction pour la préparation des extraits objets du présent brevet peuvent être choisis parmi l'eau, le propylène glycol, le butylène glycol, la glycérine, le polyéthylène glycol, les éthers méthyliques ou éthyiiques des digiycols, les polyols cycliques, les diglycols éthoxylés ou propoxylés ou tout mélange de ces solvants.The extraction solvents for the preparation of the extracts which are the subject of this patent can be chosen from water, propylene glycol, butylene glycol, glycerin, polyethylene glycol, methyl or ethyl ethers of digiycols, cyclic polyols, ethoxylated or propoxylated diglycols or any mixture of these solvents.
Les extraits peuvent être obtenus par macération de la plante dans le solvant d'extraction, pendant une durée plus ou moins longue. A la place de la macération simple, on peut employer des techniques à contre courant, la décoction, la lixiviation, l'extraction à l'aide d'ultrasons, de micro-ondes. Pour certaines applications cosmétiques il peut s'avérer utile de préparer un extrait sec à partir de l'extrait liquide. Ceci peut être réalisé par les techniques classiques de précipitation, de séchage, d'évaporation, d'atomisation ou de lyophilisation.The extracts can be obtained by maceration of the plant in the extraction solvent, for a more or less long period. Instead of simple maceration, countercurrent techniques can be used, decoction, leaching, extraction using ultrasound, microwaves. For certain cosmetic applications it may prove useful to prepare a dry extract from the liquid extract. This can be achieved by conventional precipitation, drying, evaporation, atomization or lyophilization techniques.
La composition finale destinée à être utilisée dans un produit cosmétique ou dermopharmaceutique consiste en un mélange du filtrat contenant le polysaccharide et l'extrait d'algues, en une proportion d'environ 10:1.The final composition intended for use in a cosmetic or dermopharmaceutical product consists of a mixture of the filtrate containing the polysaccharide and the algae extract, in a proportion of approximately 10: 1.
Cet exemple n'est pas limitatif; les proportions de mélange du filtrat bactérien avec l'extrait d'Haematococcus pluvialis peuvent varier de 1:1 à 1000:1 , les conditions de culture de Rhizobium meliloti peuvent varier dans les limites raisonnables et compatibles avec le métabolisme de Rhizobium meliloti (pH 4-8, température 20-40°C, composition en sucre: glucose, fructose, saccharose, milieu de culture synthétique ou contenant des peptones, des additifs vitaminés, etc.). Exemple n° 2: Efficacité cosmétique Un gel cosmétique a été formulé contenant 3% du mélange de polysaccharide et d'extrait d'Haematococcus pluvialis. Ce gel a été appliqué quotidiennement par un panel de 10 volontaires possédant la peau sèche et rugueuse au niveau de la jambe. Sur l'autre jambe, un gel placebo a été appliqué. Une étude d'hydratation au Cornéomètre (mesure de l'impédance de surface) a été menée en parallèle avec une étude des couches cornéocytaires par microscopie électronique à balayage (MEB).This example is not limitative; the mixing proportions of the bacterial filtrate with the Haematococcus pluvialis extract can vary from 1: 1 to 1000: 1, the culture conditions of Rhizobium meliloti can vary within reasonable limits and compatible with the metabolism of Rhizobium meliloti (pH 4 -8, temperature 20-40 ° C, sugar composition: glucose, fructose, sucrose, synthetic culture medium or one containing peptones, vitamin additives, etc.). Example No. 2: Cosmetic Effectiveness A cosmetic gel was formulated containing 3% of the mixture of polysaccharide and extract of Haematococcus pluvialis. This gel was applied daily by a panel of 10 volunteers with dry and rough skin on the leg. On the other leg, a placebo gel was applied. A hydration study with the Cornéometer (measurement of the surface impedance) was carried out in parallel with a study of the corneocyte layers by scanning electron microscopy (SEM).
Après 3 semaines d'application, la surface de la peau traitée au mélange poiysaccharide/extrait d'algue est nettement plus hydratée et moins rugueuse que la peau traitée au placebo: les valeurs d'hydratation lues au cornéomètre ont augmenté de +15%, les images en MEB montrent un lissage et une meilleure adhésion cellulaire.After 3 weeks of application, the surface of the skin treated with the poiysaccharide / algae extract mixture is clearly more hydrated and less rough than the skin treated with placebo: the hydration values read by the corneometer increased by + 15%, SEM images show smoothing and better cell adhesion.
Une deuxième étude a été effectuée pour comparer l'effet du polysaccharide seul et l'extrait d'Haematococcus pluvialis seul. Alors qu'aucune amélioration significative ne pouvait être constatée aux concentrations d'utilisation identique, l'extrait d'Haematococcus pluvialis seul améliore l'état de la peau quand on l'utilise à une concentration 5-10 fois plus élevée. Son prix et sa couleur ainsi que l'odeur limitent cependant l'intérêt de cette solution. Exemple n° 3: crème hydratante et nutritive BrijR 721 2.4 BrijR 72 2.6 ArlamolR E 8.0A second study was carried out to compare the effect of the polysaccharide alone and the extract of Haematococcus pluvialis alone. While no significant improvement could be seen at the concentrations of identical use, the extract of Haematococcus pluvialis alone improves the condition of the skin when used at a concentration 5-10 times higher. Its price and its color as well as the odor however limit the interest of this solution. Example No. 3: Brij R 721 moisturizing and nutritive cream 2.4 Brij R 72 2.6 Arlamol R E 8.0
Cire d'abeille 0.5Beeswax 0.5
Propylène glycol 3.0Propylene glycol 3.0
CarbopolR 941 0.25 Triéthanolamine 0.25Carbopol R 941 0.25 Triethanolamine 0.25
Mélange de polysaccharides glucuroniques et d'extrait d'Haematococcus pluvialis 5.0Mixture of glucuronic polysaccharides and Haematococcus pluvialis 5.0 extract
Eau, conservateurs, parfums qsp 100 g.Water, preservatives, perfumes qs 100 g.
Les extraits d'Haematococcus pluvialis seuls ou en association avec les polysaccharides glucuroniques objets du brevet peuvent être employés dans les produits cosmétiques et dermopharmaceutiques de toutes sortes. De telles compositions présentent des activités hydratantes et nutritives pour la peau.The extracts of Haematococcus pluvialis alone or in combination with the glucuronic polysaccharides which are the subject of the patent can be used in cosmetic and dermopharmaceutical products of all kinds. Such compositions have moisturizing and nutritive activities for the skin.
Les extraits d'Haematococcus pluvialis seuls ou en association avec les polysaccharides glucuroniques, objets du brevet peuvent trouver également trouver des applications dans tous les soins de la peau y compris le traitement antivieillissement, antirides, anti-inflammatoire, anti-radicalaire, ceux du cuir cheveluThe extracts of Haematococcus pluvialis alone or in combination with the glucuronic polysaccharides, subject of the patent can also find applications in all skin care including anti-aging, anti-wrinkle, anti-inflammatory, anti-radical, leather treatments haired
(antipelliculaire) ou de la peau acnéique et ceux qui prolongent la souplesse et la fonction protectrice de la peau.(dandruff) or acne-prone skin and those that prolong the suppleness and protective function of the skin.
Les extraits de d'Haematococcus pluvialis seuls ou en association avec les polysaccharides glucuroniques objets du présent brevet peuvent être utilisés dans toute forme galénique employée en cosmétique: émulsion H/E et E/H, laits, lotions, gels, pommades, huiles corporelles, lotions capillaires, shampooings, savons, sticks et crayons, sprays, sans que cette liste soit limitative.The extracts of Haematococcus pluvialis alone or in combination with the glucuronic polysaccharides which are the subject of this patent can be used in any galenic form used in cosmetics: O / W and W / O emulsion, milks, lotions, gels, ointments, body oils, hair lotions, shampoos, soaps, sticks and pencils, sprays, without this list being exhaustive.
Il est possible d'incorporer les extraits de Haematococcus pluvialis seuls ou en association avec les polysaccharides glucuroniques décrits dans des vecteurs cosmétiques comme les liposomes, les chylomicrons, les macro-, micro- et nanoparticules ainsi que les macro-, micro- et nanocapsules, de les absorber sur des polymères organiques poudreux, les talcs, bentonites et autres supports minéraux.It is possible to incorporate the extracts of Haematococcus pluvialis alone or in combination with the glucuronic polysaccharides described in cosmetic vectors such as liposomes, chylomicrons, macro-, micro- and nanoparticles as well as macro-, micro- and nanocapsules, absorb them on powdery organic polymers, talcs, bentonites and other mineral supports.
La concentration d'utilisation de ces extraits de Haematococcus pluvialis peut varier entre 0.01 et 90% (p/p), préférentiellement entre 0.5 et 10% dans le produit fini, en association avec les polysaccharides glucuroniques elle peut varier entre 0.001 etThe concentration of use of these extracts of Haematococcus pluvialis can vary between 0.01 and 90% (w / w), preferably between 0.5 and 10% in the finished product, in association with glucuronic polysaccharides it can vary between 0.001 and
10%, préférentiellement entre 0.1 et 1%.10%, preferably between 0.1 and 1%.
Les extraits d'Haematococcus pluvialis seuls ou en association avec les polysaccharides glucuroniques peuvent être combinés dans les compositions cosmétiques avec tout autre ingrédient habituellement utilisé en cosmétique: lipides d'extraction et ou de synthèse, polymères gélifiants et viscosants, tensioactifs et emulsifiants, principes actifs hydro- ou liposolubies, extraits d'autres plantes, extraits tissulaires, extraits marins. The extracts of Haematococcus pluvialis alone or in combination with the glucuronic polysaccharides can be combined in the cosmetic compositions with any other ingredient usually used in cosmetics: extraction and or synthetic lipids, gelling and viscosifying polymers, surfactants and emulsifiers, hydro- or liposolubies active ingredients, extracts from other plants, tissue extracts, marine extracts.

Claims

REVENDICATIONS
1. Compositions cosmétiques ou dermopharmaceutiques caractérisées en ce qu'eues contiennent un extrait de la microaigue Haematococcus pluvialis.1. Cosmetic or dermopharmaceutical compositions characterized in that they contain an extract of the microalga Haematococcus pluvialis.
2. Compositions cosmétiques ou dermopharmaceutiques selon la revendication 1 , caractérisées en ce que l'extrait d'Haematococcus pluvialis peut être associé à un polysaccharide d'origine bactérienne.2. Cosmetic or dermopharmaceutical compositions according to claim 1, characterized in that the extract of Haematococcus pluvialis can be combined with a polysaccharide of bacterial origin.
3. Procédé de préparation des compositions cosmétiques ou dermopharmaceutiques selon les revendications 1 à 2 caractérisé en ce que l'extrait Haematococcus pluvialis est obtenu grâce à une macération des algues lyophilisées ou atomisées, dans un excipient aqueux ou hydroglycoiique, suivie d'une filtration, clarification, décoloration et éventuellement conservation.3. Process for the preparation of cosmetic or dermopharmaceutical compositions according to claims 1 to 2, characterized in that the Haematococcus pluvialis extract is obtained by maceration of lyophilized or atomized algae, in an aqueous or hydroglycolic excipient, followed by filtration, clarification, discoloration and possibly conservation.
4 Procédé selon la revendication 3 caractérisé en ce que la macération peut-être remplacée par des techniques à contre courant, la décoction, la iixiviation, l 'extraction à l'aide d'ultrasons ou de micro-ondes.4 Method according to claim 3 characterized in that the maceration may be replaced by techniques against the current, decoction, iixiviation, extraction using ultrasound or microwave.
5. Procédé selon la revendication 4 caractérisé en ce que les solvants d'extraction utilisés sont choisis parmi l'eau, le propylène glycol, le butylènegiycol, la glycérine, le polyéthylèneglycol, les éthers méthyliques ou éthyliques des diglycols, les polyols cycliques, les digiycols éthoxylés ou propoxylées ou tout mélange de ces solvants.5. Method according to claim 4 characterized in that the extraction solvents used are chosen from water, propylene glycol, butylènegiycol, glycerine, polyethylene glycol, methyl or ethyl ethers of diglycols, cyclic polyols, ethoxylated or propoxylated digiycols or any mixture of these solvents.
6. Procédé de fabrication des compositions cosmétiques ou dermo- pharmaceutiques selon la revendication 2 caractérisé en ce que le polysaccharide est obtenu à partir de Rhizobium meliloti et en particulier de Rhizobium meliloti NCIMB 40472, cultivée sur un milieu contenant du saccharose, de l'extrait de levure et des sels phosphoriques de potassium, de magnésium et de sodium pendant 48 heures, à 30βC et à pH 7. 6. A method of manufacturing cosmetic or dermopharmaceutical compositions according to claim 2 characterized in that the polysaccharide is obtained from Rhizobium meliloti and in particular Rhizobium meliloti NCIMB 40472, cultivated on a medium containing sucrose, the extract yeast and potassium, magnesium and sodium phosphoric salts for 48 hours, at 30 β C and at pH 7.
7. Procédé selon la revendication 6 caractérisé en ce qu'à la fin de la culture, les polysaccharides sont obtenus par élimination des micro-organismes par filtration tangentielle, le filtrat étant alors conservé par des substances antimicrobiennes appropriées.7. Method according to claim 6 characterized in that at the end of the culture, the polysaccharides are obtained by elimination of the microorganisms by tangential filtration, the filtrate then being preserved by appropriate antimicrobial substances.
8. Compositions cosmétiques ou dermopharmaceutiques selon l'une quelconque des revendications 1 à 2 ou obtenues par le procédé selon l'une des revendication 3 à 7 caractérisées en ce que les extraits d'Haematococcus pluvialis seuls ou en association avec les polysaccharides glucuroniques obtenus à partir de Rhizobium meliloti sont utilisés soit sous forme liquide, soit sous forme sèche obtenue par les techniques classiques de précipitation, de séchage, d 'évaporation, d'atomisation ou de lyophilisation.8. Cosmetic or dermopharmaceutical compositions according to any one of claims 1 to 2 or obtained by the process according to one of claims 3 to 7 characterized in that the extracts of Haematococcus pluvialis alone or in combination with the glucuronic polysaccharides obtained at from Rhizobium meliloti are used either in liquid form or in dry form obtained by conventional precipitation, drying, evaporation, atomization or lyophilization techniques.
9 Compositions cosmétiques ou dermopharmaceutiques selon la revendication 8 caractérisées en ce que la concentration d'utilisation des extraits d'Haematococcus pluvialis utilisés seuls peut varier entre 0.01% et 90 % (p/p), préférentiellement entre 0.5 et 10% dans le produit fini ou, dans le cas d'utilisation en association avec les polysaccharides glucuroniques obtenus à partir de Rhizobium meliloti, entre 0.001 et 10%, préférentiellement entre 0.1 et9 Cosmetic or dermopharmaceutical compositions according to claim 8 characterized in that the concentration of use of the extracts of Haematococcus pluvialis used alone can vary between 0.01% and 90% (w / w), preferably between 0.5 and 10% in the finished product or, in the case of use in combination with the glucuronic polysaccharides obtained from Rhizobium meliloti, between 0.001 and 10%, preferably between 0.1 and
1%, en poids, dans le produit fini. 1%, by weight, in the finished product.
10 Compositions cosmétiques ou dermopharmaceutiques selon l'une quelconque des revendications 8 ou 9 caractérisées en ce que les extraits d'Haematococcus pluvialis seuls ou en association avec les polysaccharides glucuroniques obtenus à partir de Rhizobium meliloti peuvent être utilisés dans toute forme galénique employée en cosmétique ou dermopharmacie: émulsions H/E et E/H, laits, lotions, polymères gélifiants et viscosants, tensioactifs et émulsifiants, pommades, lotions capillaires, shampooings, savons, sticks et crayons, sprays, huiles corporelles.10 Cosmetic or dermopharmaceutical compositions according to any one of claims 8 or 9 characterized in that the extracts of Haematococcus pluvialis alone or in combination with the glucuronic polysaccharides obtained from Rhizobium meliloti can be used in any dosage form used in cosmetics or dermopharmacy: O / W and W / O emulsions, milks, lotions, gelling and viscous polymers, surfactants and emulsifiers, ointments, hair lotions, shampoos, soaps, sticks and pencils, sprays, body oils.
11 Compositions cosmétiques ou dermopharmaceutiques selon l'une quelconque des revendications 8 à 10 caractérisées en ce que les extraits d'Haematococcus pluvialis seuls ou en association avec les polysaccharides glucuroniques obtenus à partir de Rhizobium meliloti sont incorporés dans des vecteurs cosmétiques comme les liposomes, les chylomicrons, les macro-, micro- et nanoparticuies ainsi que les macro-, micro- et nanocapsules, ou absorbés sur des polymères organiques poudreux, les talcs, bentonites et autres supports minéraux.11 Cosmetic or dermopharmaceutical compositions according to any one of Claims 8 to 10, characterized in that the extracts of Haematococcus pluvialis alone or in combination with the glucuronic polysaccharides obtained from Rhizobium meliloti are incorporated into cosmetic vectors such as liposomes, chylomicrons, macro-, micro- and nanoparticles as well as macro-, micro- and nanocapsules, or absorbed on powdery organic polymers, talcs, bentonites and other mineral supports.
12. Compositions cosmétiques ou dermopharmaceutiques selon l'une quelconque des revendications 8 à 11 caractérisées en ce que les extraits d'Haematococcus pluvialis seuls ou en association avec les polysaccharides glucuroniques obtenus à partir de Rhizobium meliloti sont combinés dans les compositions cosmétiques avec tout autre ingrédient habituellement utilisé en cosmétique: lipides d'extraction et/ou de synthèse, polymères gélifiants et viscosants, tensioactifs et émulsifiants, principes actifs hydro- ou liposolubies, extraits d'autres plantes, extraits tissulaires, extraits marins. 12. Cosmetic or dermopharmaceutical compositions according to any one of claims 8 to 11 characterized in that the extracts of Haematococcus pluvialis alone or in combination with the glucuronic polysaccharides obtained from Rhizobium meliloti are combined in the cosmetic compositions with any other ingredient usually used in cosmetics: extraction and / or synthetic lipids, gelling and viscosifying polymers, surfactants and emulsifiers, hydro- or liposolubies active principles, extracts from other plants, tissue extracts, marine extracts.
13. Utilisation cosmétique de la composition selon l'une quelconque des revendications 1 à 2 ou 8 à 12, pour les soins de la peau, y compris le traitement anti-vieillissement, antirides, anti-inflammatoire, anti-radicalaire, ceux du cuir chevelu (antipelliculaire) ou de la peau acnéique et ceux qui prolongent la souplesse et la fonction protectrice de la peau.13. Cosmetic use of the composition according to any one of claims 1 to 2 or 8 to 12, for skin care, including anti-aging, anti-wrinkle, anti-inflammatory, anti-radical, leather treatments. scalp (dandruff) or acne-prone skin and those that prolong the suppleness and protective function of the skin.
14 Utilisation de la composition selon l'une quelconque des revendications 1 à 2 ou14 Use of the composition according to any one of claims 1 to 2 or
8 à 12, pour la préparation d'un médicament pour les soins de la peau, y compris le traitement anti-vieillissement, antirides, anti-inflammatoire, anti-radicalaire, ceux du cuir chevelu (antipelliculaire) ou de la peau acnéique et ceux qui prolongent la souplesse et la fonction protectrice de la peau. 8 to 12, for the preparation of a medicament for skin care, including anti-aging, anti-wrinkle, anti-inflammatory, anti-radical treatment, those of the scalp (dandruff) or of acne skin and those which prolong the suppleness and the protective function of the skin.
PCT/FR1998/001831 1997-09-12 1998-08-21 Composition for cosmetic or dermopharmaceutical use containing a combination of algae extract and exopolysaccharides WO1999013855A1 (en)

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WO2002012183A1 (en) * 2000-08-04 2002-02-14 Haitai Foods Products Co., Ltd. Process for extracting astaxanthin pigment from blue-green algae and extracted pigment thereof
US8021695B2 (en) 2002-02-15 2011-09-20 Arch Personal Care Products, L.P. Personal care composition containing leghemoglobin
CN102417549A (en) * 2011-11-07 2012-04-18 沈阳科思高科技有限公司 Efficient extracting method for active polysaccharide of brown alga based on microwave chemistry
CN104306828A (en) * 2014-11-13 2015-01-28 山东中大药业有限公司 Preparation method of liver benefiting tablet containing nepal dock root and day lily and application of liver benefiting tablet to preparation of drug for restraining multiplication of lymphoma cell YAC-1 cell
US20150196475A1 (en) * 2008-12-11 2015-07-16 Sederma, S.A.S. Cosmetic Composition Containing Acetylated Oligoglucuronans
CN105213974A (en) * 2015-10-19 2016-01-06 青岛市中心医院 One treats lymphadenomatous Chinese medicine composition and application thereof
US9775908B2 (en) 2007-07-10 2017-10-03 Egis Gyogyszergyar Nyilvanosan Mukodo Reszvenytarsasag Pharmaceutical preparations containing highly volatile silicones
US9925135B2 (en) 2011-01-31 2018-03-27 Sederma, S.A.S. Use of an extract of plant origin of Globularia and method for obtaining said extract by in vitro plant culture
US10045935B2 (en) 2012-07-31 2018-08-14 Egis Pharmaceuticals Plc Transdermal formulation containing COX inhibitors
CN110870842A (en) * 2018-08-29 2020-03-10 伽蓝（集团）股份有限公司 Application of haematococcus pluvialis extract
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WO2001083437A1 (en) * 2000-05-04 2001-11-08 Haitai Food Products Co., Ltd. Process for extracting astaxanthin pigment from yeast and extracted pigment thereof
WO2002012183A1 (en) * 2000-08-04 2002-02-14 Haitai Foods Products Co., Ltd. Process for extracting astaxanthin pigment from blue-green algae and extracted pigment thereof
US8021695B2 (en) 2002-02-15 2011-09-20 Arch Personal Care Products, L.P. Personal care composition containing leghemoglobin
US9775908B2 (en) 2007-07-10 2017-10-03 Egis Gyogyszergyar Nyilvanosan Mukodo Reszvenytarsasag Pharmaceutical preparations containing highly volatile silicones
US10159636B2 (en) * 2008-12-11 2018-12-25 Sederma, S.A.S. Cosmetic composition containing acetylated oligoglucuronans
US20150196475A1 (en) * 2008-12-11 2015-07-16 Sederma, S.A.S. Cosmetic Composition Containing Acetylated Oligoglucuronans
US10758473B2 (en) 2011-01-31 2020-09-01 Sederma, S.A.S. Extract of plant origin of globularia and method for obtaining said extract by in vitro plant culture
US9925135B2 (en) 2011-01-31 2018-03-27 Sederma, S.A.S. Use of an extract of plant origin of Globularia and method for obtaining said extract by in vitro plant culture
CN102417549A (en) * 2011-11-07 2012-04-18 沈阳科思高科技有限公司 Efficient extracting method for active polysaccharide of brown alga based on microwave chemistry
US10045935B2 (en) 2012-07-31 2018-08-14 Egis Pharmaceuticals Plc Transdermal formulation containing COX inhibitors
US11154535B2 (en) 2012-07-31 2021-10-26 Egis Pharmaceuticals Plc Transdermal formulation containing COX inhibitors
CN104306828A (en) * 2014-11-13 2015-01-28 山东中大药业有限公司 Preparation method of liver benefiting tablet containing nepal dock root and day lily and application of liver benefiting tablet to preparation of drug for restraining multiplication of lymphoma cell YAC-1 cell
CN105213974A (en) * 2015-10-19 2016-01-06 青岛市中心医院 One treats lymphadenomatous Chinese medicine composition and application thereof
CN110870842A (en) * 2018-08-29 2020-03-10 伽蓝（集团）股份有限公司 Application of haematococcus pluvialis extract
EP4089163A1 (en) 2021-05-11 2022-11-16 Université Clermont Auvergne Polymeric compound of glucuronic acid with phenolic groups, gel-forming composition comprising such a compound and method for producing the same
WO2022238441A1 (en) 2021-05-11 2022-11-17 Universite Clermont Auvergne Polymeric compound of glucuronic acid with phenolic groups, gel-forming composition comprising such a compound and method for producing the same

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