FR2716374A1 - Extracts of Garcinia and Hibiscus have cosmetic and dermatological use - Google Patents

Extracts of Garcinia and Hibiscus have cosmetic and dermatological use Download PDF

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FR2716374A1
FR2716374A1 FR9401956A FR9401956A FR2716374A1 FR 2716374 A1 FR2716374 A1 FR 2716374A1 FR 9401956 A FR9401956 A FR 9401956A FR 9401956 A FR9401956 A FR 9401956A FR 2716374 A1 FR2716374 A1 FR 2716374A1
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cosmetic
compositions according
extracts
extract
garcinia
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FR2716374B1 (en
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Greff Daniel
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Sederma SA
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Sederma SA
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/06Preparations for care of the skin for countering cellulitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/38Clusiaceae, Hypericaceae or Guttiferae (Hypericum or Mangosteen family), e.g. common St. Johnswort
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00Preparations for affecting hair growth

Abstract

Cosmetic and dermatological compsns. with anti-cellulitic activity, which favour lipolysis and/or regulate lipogenesis and cutaneous cellular renewal, and protect against hair loss, contain an extract of Garcinia cambogia or Hibiscus cannabinus vulgaris L.

Description

Les fruits de la plante Garcinia cambogia sont utilisés dans la cuisineThe fruits of the Garcinia cambogia plant are used in cooking

indienne traditionelle. On leur attribue des proprietés toniques, stimulantes. Les feuilles d'Hibiscus cannabinus vulgaris L, plante du Madagascar, n'ont pas d'application connue.  traditional Indian. They are attributed with invigorating, stimulating properties. The leaves of Hibiscus cannabinus vulgaris L, a plant from Madagascar, have no known application.

L'objet du présent brevet est la découverte que les extraits obtenus à partir de ces plantes, surtout des fruits et particulièrement des écorces des fruits de Garcinia, et des feuilles d'Hibiscus, possèdent des activités biochimiques utiles pour l'application cosmétique et dermopharmaceutique. Il est décrit (R.N. Rao et al. in Nutrition Research, 1988, Vol. 8, pp. 209-212) que l'hydroxycitrate, principal acide contenu dans le fruit de Garcinia (que l'on retrouve également dans les feuilles d'Hibiscus), possède le pouvoir d'inhibition de certaines enzymes impliquées dans la lipogénèse, en particulier 1' ATP:citrate lyase (EC 4. 5.3.8).  The object of this patent is the discovery that the extracts obtained from these plants, especially fruits and especially the bark of Garcinia fruits, and Hibiscus leaves, have biochemical activities useful for cosmetic and dermopharmaceutical application . It is described (RN Rao et al. In Nutrition Research, 1988, Vol. 8, pp. 209-212) that hydroxycitrate, the main acid contained in the fruit of Garcinia (which is also found in the leaves of Hibiscus), has the power to inhibit certain enzymes involved in lipogenesis, in particular 1 ATP: citrate lyase (EC 4. 5.3.8).

Les extraits de Garcinia cambogia ou d'Hibiscus cannabinus vulgaris L objets du présent brevet peuvent donc être utilisés dans le domaine de la cosmétique, surtout pour l'application anticellulitique, amincissante, anti-capitons, raffermissante.  The extracts of Garcinia cambogia or Hibiscus cannabinus vulgaris The objects of this patent can therefore be used in the field of cosmetics, especially for the anti-cellulite, slimming, anti-dimpling, firming application.

A titre d'exemple nous décrivons une extraction de Garcinia cambogia qui peut être industrialisée à faible coût: g d'écorce sèche de fruit de Garcinia cambogia sont broyés, puis macérés pendant 24 heures dans 1500 ml d'un mélange d'eau et de glycérine à 40 C. Après filtration on récupère un filtrat rose, limpide, de pH acide (pH < 3) que l'on concentre sous vide à 100 mi. On neutralise à la soude puis l'on chauffe à 80 C pendant 30 minutes pour transformer toute la lactone présente en sel trisodique.  As an example, we describe an extraction of Garcinia cambogia which can be industrialized at low cost: g of dry bark of Garcinia cambogia fruit are ground, then macerated for 24 hours in 1500 ml of a mixture of water and glycerin at 40 C. After filtration, a pink, clear filtrate with an acidic pH (pH <3) is recovered which is concentrated under vacuum to 100 ml. It is neutralized with sodium hydroxide and then heated at 80 ° C. for 30 minutes to transform all the lactone present into trisodium salt.

Pour certaines applications il peut s'avérer utile de préparer un extrait sec à partir de l'extrait liquide. Ceci peut être réalisé par les techniques classiques de séchage, d'évaporation, d'atomisation ou de lyophilisation.  For certain applications it may prove useful to prepare a dry extract from the liquid extract. This can be achieved by conventional drying, evaporation, atomization or lyophilization techniques.

Pour précipiter l'hydroxycitrate pur, on ajoute 5 fois le volume en éthanol et on lave le précipité à l'éthanol, puis on sèche sous vide.  To precipitate pure hydroxycitrate, 5 times the volume of ethanol is added and the precipitate is washed with ethanol, then dried under vacuum.

Néanmoins, pour l'application cosmétique, on peut se contenter de l'extrait filtré, concentré à convenance, neutralisé et décoloré selon les méthodes standards.  However, for the cosmetic application, one can be satisfied with the filtered extract, concentrated to suit, neutralized and discolored according to standard methods.

Les solvants d'extraction peuvent être choisis parmi l'eau, les mélanges glycérine/eau, propylène glycol/eau, butylène glycolleau.  The extraction solvents can be chosen from water, glycerin / water mixtures, propylene glycol / water, butylene glycolleau.

L'exemple donné de fabrication de l'extrait n'est pas limitatif. Les améliorations, optimisations et modifications du procédé envisageables sont évidentes pour l'homme de l'art. A la place de la macération simple, on peut employer des techniques à contre courant, la décoction, la lixiviation, l'extractlon à l'aide d'ultrasons, de micro-ondes associées ou non aux solvants.  The example given for making the extract is not limiting. The conceivable improvements, optimizations and modifications of the process are obvious to those skilled in the art. Instead of simple maceration, countercurrent techniques can be used, decoction, leaching, extraction using ultrasound, microwaves, whether or not combined with solvents.

L'activité biochimique la plus évidente de l'extrait est le pouvoir inhibiteur de l'enzyme ATP:citrate lyase et donc l'inhibition de la lipogénèse.  The most obvious biochemical activity of the extract is the inhibitory power of the ATP enzyme: citrate lyase and therefore the inhibition of lipogenesis.

Cette activité est particulièrement intéressante quand elle est associée à des substances lipolytiques ou favorisant la lipolyse (lipases, caféine, mucopolysaccharides, carnitine).  This activity is particularly interesting when it is associated with lipolytic substances or promoting lipolysis (lipases, caffeine, mucopolysaccharides, carnitine).

Les extraits ainsi obtenus peuvent être employés dans les produits cosmétiques et dermopharmaceutiques de toute sorte.  The extracts thus obtained can be used in cosmetic and dermopharmaceutical products of all kinds.

De telles compositions présentent des activités anti-cellulitique, favorisent la lipolyse et/ou régulent la lipogénèse, le renouvellement cellulaire cutané, et protègent contre la chute des cheveux.  Such compositions have anti-cellulite activities, promote lipolysis and / or regulate lipogenesis, skin cell renewal, and protect against hair loss.

Leur utilisation principale est la cosmétique de soin anti cellulitique, amincissante, raffermissante et antiséborrhéique. En outre, les effets toniques de l'extrait contribuent à une restructuration de l'épiderme, améliorent l'aspect de la peau, diminuent la microcirculation capillaire, donnent élasticité et fermeté aux peaux fatiguées.  Their main use is anti-cellulite, slimming, firming and antiseborrheic skincare cosmetics. In addition, the tonic effects of the extract contribute to a restructuring of the epidermis, improve the appearance of the skin, decrease capillary microcirculation, give elasticity and firmness to tired skin.

Les extraits de Garcinia cambogia ou d'Hibiscus cannabinus vulgaris L objets du brevet peuvent trouver également application dans les traitements du cuir chevelu (anti-pelliculaire) et de la peau acnéique.  The extracts of Garcinia cambogia or Hibiscus cannabinus vulgaris The subject of the patent can also find application in the treatment of the scalp (anti-dandruff) and acne-prone skin.

Les extraits de Garcinia cambogia ou d'Hibiscus cannabinus vulgaris L objet du présent brevet peuvent être utilisés dans toute forme galénique employée en cosmétique: émulsions H/E et E/H, laits, lotions, gels, pommades, huiles corporelles, lotions capillaires, shampooings, savons, sticks et crayons, sprays, sans que cette liste soit limitative.  The extracts of Garcinia cambogia or Hibiscus cannabinus vulgaris The subject of this patent can be used in any dosage form used in cosmetics: O / W and W / O emulsions, milks, lotions, gels, ointments, body oils, hair lotions, shampoos, soaps, sticks and pencils, sprays, without this list being exhaustive.

Il est possible d'incorporer les extraits de Garcinia cambogia ou d'Hibiscus cannabinus vulgaris L décrits, dans des vecteurs cosmétiques comme les liposomes, les chylomicrons, les macro-, micro- et nanoparticules ainsi que les macro-, micro- et nanocapsules, de les absorber sur des polymères organiques poudreux, les talcs, bentonites et autres supports minéraux.  It is possible to incorporate the extracts of Garcinia cambogia or of Hibiscus cannabinus vulgaris L described, in cosmetic vectors such as liposomes, chylomicrons, macro-, micro- and nanoparticles as well as macro-, micro- and nanocapsules, absorb them on powdery organic polymers, talcs, bentonites and other mineral supports.

La concentration d'utilisation de ces extraits de Garcinia carnbogia ou d'Hibiscus cannabinus vulgaris L peut varier entre 0.01 et 50% (p/p), préférentiellement entre 0.5 et 10% dans le produit fini. En dessous de ces valeurs, les effets sont négligeables, en dessus il est difficile de formuler un produit cosmétique  The concentration of use of these extracts of Garcinia carnbogia or Hibiscus cannabinus vulgaris L can vary between 0.01 and 50% (w / w), preferably between 0.5 and 10% in the finished product. Below these values, the effects are negligible, above it is difficult to formulate a cosmetic product

acceptable.acceptable.

Les extraits de Garcinia cambogia ou d'Hibiscus cannabinus vulgaris L peuvent être combinés dans les compositions cosmétiques avec tout autre ingrédient habituellement utilisé en cosmétique: lipides d'extraction et/ou de synthèse, polymères gélifiants et viscosants, tensioactifs et émulsifiants, principes actifs hydro- ou liposolubles, extraits d'autres plantes, extraits tissulaires, extraits marins.  Garcinia cambogia or Hibiscus cannabinus vulgaris L extracts can be combined in cosmetic compositions with any other ingredient usually used in cosmetics: extraction and / or synthetic lipids, gelling and viscosifying polymers, surfactants and emulsifiers, hydro active ingredients - or fat-soluble, extracts from other plants, tissue extracts, marine extracts.

Claims (11)

REVENDICATIONS 1) Compositions cosmétiques ou dermopharmaceutiques à activité anticellulitique, favorisant la lipolyse et/ou régulant la lipogénèse et le renouvellement cellulaire cutané, protégeant contre la chute des cheveux, caractérisées en ce qu'elles contiennent un extrait de Garcinia cambogia ou d'Hibiscus cannabinus vuigaris L.  1) Cosmetic or dermopharmaceutical compositions with anticellulitic activity, promoting lipolysis and / or regulating lipogenesis and skin cell renewal, protecting against hair loss, characterized in that they contain an extract of Garcinia cambogia or Hibiscus cannabinus vuigaris L. 2) Compositions cosmétiques ou dermopharmaceutiques selon la revendication 1 caractérisées en ce que l'extrait de Garcinia cambogia précité est obtenu à partir du fruit, en particulier à partir de l'écorce des fruits de cette plante.2) Cosmetic or dermopharmaceutical compositions according to claim 1 characterized in that the above-mentioned extract of Garcinia cambogia is obtained from the fruit, in particular from the rind of the fruits of this plant. 3) Compositions cosmétiques ou dermopharmaceutiques selon la revendication 1 caractérisées en ce que l'extrait est obtenu à partir d'Hibiscus cannabinus vulgaris L en particulier à partir des feuilles de cette plante.  3) Cosmetic or dermopharmaceutical compositions according to claim 1 characterized in that the extract is obtained from Hibiscus cannabinus vulgaris L in particular from the leaves of this plant. 4) Compositions cosmétiques ou dermopharmaceutiques selon l'une quelconque des revendications de 1 à 3 caractérisées en ce que l'extrait de Garcinia cambogia ou d'Hibiscus cannabinus vulgaris L est obtenu grâce à une extraction de la matière sèche au moyen des techniques de macération, de lixiviation, de décoction, d'extraction à contre courant, d'extraction à l'aide d'ultrasons, de micro-ondes associée ou non aux solvants.  4) Cosmetic or dermopharmaceutical compositions according to any one of Claims 1 to 3, characterized in that the extract of Garcinia cambogia or of Hibiscus cannabinus vulgaris L is obtained by extraction of the dry matter by maceration techniques , leaching, decoction, extraction against the current, extraction using ultrasound, microwave associated or not with solvents. 5) Compositions cosmétiques ou dermopharmaceutiques selon la revendication 4 caractérisées en ce que le solvant d'extraction est choisi parmi le groupe constitué par: I'eau, les mélanges glycérine/eau, propylène glycol/eau, butylène glycol/eau.  5) Cosmetic or dermopharmaceutical compositions according to claim 4, characterized in that the extraction solvent is chosen from the group consisting of: water, glycerin / water mixtures, propylene glycol / water, butylene glycol / water. 6) Compositions cosmétiques ou dermophaceutiques selon l'une quelconque des revendications de 1 à 5 caractérisées en ce que l'extrait est utilisé soit sous forme liquide soit sous forme sèche obtenue par atomisation, évaporation ou lyophilisation.  6) Cosmetic or dermophaceutical compositions according to any one of claims from 1 to 5 characterized in that the extract is used either in liquid form or in dry form obtained by atomization, evaporation or lyophilization. 7) Compositions cosmétiques o dermophaceutiques selon rune quelconque des revendications de 1 à 6 caractérisées en ce que la concentration d'utilisation en extrait de Garcinia carnbogia ou d'Hibisc_ cannanus u/gar/s L est comprise entre 0.01 et 50% (p/p), préférentiellement entre 0.5 et 10% dans le produit fini.  7) Cosmetic or dermophaceutical compositions according to any one of Claims 1 to 6, characterized in that the concentration of use in extract of Garcinia carnbogia or of Hibisc_ cannanus u / gar / s L is between 0.01 and 50% (p / p), preferably between 0.5 and 10% in the finished product. 8) Compositions cosmétiques ou dermophannrmaceutiques selon rune quelconque des revendications de 1 à 7 caractérisées en ce que les extraits de Garcinia carnmbogia ou d'H/lLsc: cannab/nus pdgaris L sont utilisés dans toute forme galénique employee en cosmétique ou dermopharmacie à savoir, les émulsions H/E et E/H, laits, lotions, gels, pommades, huiles corporelles, lotions capillaires, shampooings, savons, sticks et crayons, sprays.  8) Cosmetic or dermophannrmaceutical compositions according to any of claims 1 to 7, characterized in that the extracts of Garcinia carnmbogia or of H / lLsc: cannab / nudes pdgaris L are used in any galenical form used in cosmetics or dermopharmacy, namely, O / W and W / O emulsions, milks, lotions, gels, ointments, body oils, hair lotions, shampoos, soaps, sticks and pencils, sprays. 9) Compositions cosmétiques ou dermopharmaceutiques selon quelconque des revendications de 1 à 8 caractérisées en ce que les extraits de Garcinia cambogia ou d' Hibiscus cannaebinus vulgaris L sont incorporés dans des vecteurs cosmétiques comme les liposomes, les chylomicrons, les macro-, micro- et nanoparticules ainsi que les macro-, micro- et nanocapsules, ou absorbés sur des polymères organiques poudreux, les talcs, bentonites et autres supports minéraux.  9) Cosmetic or dermopharmaceutical compositions according to any one of claims 1 to 8, characterized in that the extracts of Garcinia cambogia or of Hibiscus cannaebinus vulgaris L are incorporated into cosmetic vectors such as liposomes, chylomicrons, macro-, micro- and nanoparticles as well as macro-, micro- and nanocapsules, or absorbed on powdery organic polymers, talcs, bentonites and other mineral supports. 10) Compositions cosmétiques ou dermnopharmaceutiques selon rune quelconque des revendications de 1 à 9 caractérisées en ce que les extraits de Garc/nha cambogia ou c'/H-scu cannabinus wUnaris L sont combinés dans les compositions cosmétiques avec tout autre ingrédient habituellement utilisé en cosmétique: lipides crextacfion et/ou de syrnthèse, polymères gélifiants et viscosants, tensioactifs et émulsifiants, principes actifs hydro- ou liposolubles, extraits de plantes.  10) Cosmetic or dermnopharmaceutical compositions according to any one of claims 1 to 9, characterized in that the extracts of Garc / nha cambogia or c '/ H-scu cannabinus wUnaris L are combined in the cosmetic compositions with any other ingredient usually used in cosmetics : crextacfion and / or syrnthesis lipids, gelling and viscosifying polymers, surfactants and emulsifiers, water- or liposoluble active principles, plant extracts. extraits tissulaires, extraits marins.  tissue extracts, marine extracts. 11) Compositions cosmétiques ou dermophamaceutiques selon l'une quelconque des revendications de 1 à 10 caractérisées en ce que les extraits de Garcinia cambogia ou d'i-bftics cannabinus vulgaris L sont utilisés dans les applications cosmétiques pour tous les soins de la peau y compris le traitement anticellulitique, raffermissant, anti- séborrhéique, tonique, de restructuration de l'épiderme, d'amélioration de l'aspect de la peau, pour le traitement du cuir chevelu et de la peau acnéique.  11) Cosmetic or dermophamaceutical compositions according to any one of claims 1 to 10, characterized in that the extracts of Garcinia cambogia or of i-bftics cannabinus vulgaris L are used in cosmetic applications for all skin care including anti-cellulite, firming, anti-seborrheic, tonic treatment, restructuring of the epidermis, improvement of the appearance of the skin, for the treatment of the scalp and acne-prone skin.
FR9401956A 1994-02-18 1994-02-18 New cosmetic or dermopharmaceutical compositions containing plant extracts. Expired - Fee Related FR2716374B1 (en)

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Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2106689A1 (en) * 1996-04-18 1997-11-01 Cabo Soler Jose New formulation based on hydroxycitric acid (salts and derivatives) and the cosmetic and pharmaceutical applications thereof by the percutaneous topical route.
FR2754820A1 (en) * 1996-10-22 1998-04-24 Ravi Shrivastava MAGNESIUM (-) HYDROXYCITRATE, PREPARATION METHOD, APPLICATIONS, AND PARTICULARLY PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME
FR2801789A1 (en) * 1999-12-02 2001-06-08 Clarins Lab Compositions comprise keratolin, a lipogenesis inhibitor and excipients for topical application, have a slimming effects on the face
EP1402886A1 (en) * 2001-05-28 2004-03-31 Kanebo, Limited Lipolysis accelerator, cosmetic skin preparation for body weight reduction and food or beverage composition each containing the same, and method for reducing body weight and medicinal use each based on activity of the same
WO2004074216A2 (en) * 2003-02-21 2004-09-02 Vama Farmacosmetica S.R.L. Carnitine salt, preliposome which contains it and dermo-cosmetic formula for topical use based upon said carnitine salt
EP1502598A2 (en) * 2003-07-29 2005-02-02 Kao Corporation Lipolysis stimulator
WO2006033476A1 (en) * 2004-09-24 2006-03-30 Showa Denko K.K. Hydroxycitric acid derivatives and skin external preparations containing the same
US7025985B2 (en) 2001-05-28 2006-04-11 Kanebo, Ltd. Dihydroxyphenyl compounds and glucoside compounds thereof
WO2007135083A1 (en) 2006-05-22 2007-11-29 Beiersdorf Preparations for sebum reduction with a content of hydroxycitrate as active principle
WO2011128339A1 (en) * 2010-04-12 2011-10-20 Dsm Ip Assets B.V. Hair treatment composition containing gambogic acid, ester or amide
CN113249512A (en) * 2021-05-28 2021-08-13 广西壮族自治区农业科学院 Method for identifying different cytoplasms of kenaf based on difference of mitochondrial gene transcripts and application

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US3764692A (en) * 1970-09-30 1973-10-09 Hoffmann La Roche Method of treating obesity
US4511555A (en) * 1982-09-27 1985-04-16 Faust Valerie F Herbal hair treatment compositions
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DE2052131A1 (en) * 1969-10-29 1971-05-06 F Hoffmann La Roche & Co AG, Ba sei (Schweiz) preparation
US3764692A (en) * 1970-09-30 1973-10-09 Hoffmann La Roche Method of treating obesity
US4511555A (en) * 1982-09-27 1985-04-16 Faust Valerie F Herbal hair treatment compositions
WO1992016184A1 (en) * 1991-03-15 1992-10-01 Aarhus Oliefabrik A/S Fat compositions and their use in cosmetic and pharmaceutical emulsion products

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2106689A1 (en) * 1996-04-18 1997-11-01 Cabo Soler Jose New formulation based on hydroxycitric acid (salts and derivatives) and the cosmetic and pharmaceutical applications thereof by the percutaneous topical route.
FR2754820A1 (en) * 1996-10-22 1998-04-24 Ravi Shrivastava MAGNESIUM (-) HYDROXYCITRATE, PREPARATION METHOD, APPLICATIONS, AND PARTICULARLY PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME
WO1998017671A1 (en) * 1996-10-22 1998-04-30 Ravi Shrivastava Magnesium (-)hydroxycitrate, method of preparation, applications, and compositions in particular pharmaceutical containing same
US6221901B1 (en) * 1996-10-22 2001-04-24 Ravi Shrivastava Magnesium (-)hydroxycitrate, method of preparation, applications, and compositions in particular pharmaceutical containing same
FR2801789A1 (en) * 1999-12-02 2001-06-08 Clarins Lab Compositions comprise keratolin, a lipogenesis inhibitor and excipients for topical application, have a slimming effects on the face
US7025985B2 (en) 2001-05-28 2006-04-11 Kanebo, Ltd. Dihydroxyphenyl compounds and glucoside compounds thereof
EP1402886A1 (en) * 2001-05-28 2004-03-31 Kanebo, Limited Lipolysis accelerator, cosmetic skin preparation for body weight reduction and food or beverage composition each containing the same, and method for reducing body weight and medicinal use each based on activity of the same
EP1402886A4 (en) * 2001-05-28 2004-10-06 Kanebo Ltd Lipolysis accelerator, cosmetic skin preparation for body weight reduction and food or beverage composition each containing the same, and method for reducing body weight and medicinal use each based on activity of the same
US7879347B2 (en) 2001-05-28 2011-02-01 Kao Corporation Dihydroxyphenyl compounds and glucoside compounds thereof
WO2004074216A2 (en) * 2003-02-21 2004-09-02 Vama Farmacosmetica S.R.L. Carnitine salt, preliposome which contains it and dermo-cosmetic formula for topical use based upon said carnitine salt
WO2004074216A3 (en) * 2003-02-21 2004-11-04 Vama Farmacosmetica S R L Carnitine salt, preliposome which contains it and dermo-cosmetic formula for topical use based upon said carnitine salt
EP1502598A3 (en) * 2003-07-29 2005-03-30 Kao Corporation Lipolysis stimulator
US7300675B2 (en) 2003-07-29 2007-11-27 Kao Corporation Lipolysis stimulator
EP1502598A2 (en) * 2003-07-29 2005-02-02 Kao Corporation Lipolysis stimulator
WO2006033476A1 (en) * 2004-09-24 2006-03-30 Showa Denko K.K. Hydroxycitric acid derivatives and skin external preparations containing the same
US7846970B2 (en) 2004-09-24 2010-12-07 Showa Denko K.K. Hydroxycitric acid derivatives and skin external preparations containing the same
WO2007135083A1 (en) 2006-05-22 2007-11-29 Beiersdorf Preparations for sebum reduction with a content of hydroxycitrate as active principle
WO2011128339A1 (en) * 2010-04-12 2011-10-20 Dsm Ip Assets B.V. Hair treatment composition containing gambogic acid, ester or amide
CN102844017A (en) * 2010-04-12 2012-12-26 帝斯曼知识产权资产管理有限公司 Hair treatment composition containing gambogic acid, ester or amide
US20130195777A1 (en) * 2010-04-12 2013-08-01 Dsm Ip Assts B.V. Hair treatment composition containing gambogic acid, ester or amide
CN102844017B (en) * 2010-04-12 2015-10-21 帝斯曼知识产权资产管理有限公司 Hair care composition containing gamlogic acid, Resina garciniae acid esters or Resina garciniae amide
US9445979B2 (en) 2010-04-12 2016-09-20 Dsm Ip Assets B.V. Hair treatment composition containing gambogic acid, ester or amide
CN113249512A (en) * 2021-05-28 2021-08-13 广西壮族自治区农业科学院 Method for identifying different cytoplasms of kenaf based on difference of mitochondrial gene transcripts and application

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