FR2716374A1 - Extracts of Garcinia and Hibiscus have cosmetic and dermatological use - Google Patents
Extracts of Garcinia and Hibiscus have cosmetic and dermatological use Download PDFInfo
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- FR2716374A1 FR2716374A1 FR9401956A FR9401956A FR2716374A1 FR 2716374 A1 FR2716374 A1 FR 2716374A1 FR 9401956 A FR9401956 A FR 9401956A FR 9401956 A FR9401956 A FR 9401956A FR 2716374 A1 FR2716374 A1 FR 2716374A1
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- cosmetic
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- garcinia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/06—Preparations for care of the skin for countering cellulitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/38—Clusiaceae, Hypericaceae or Guttiferae (Hypericum or Mangosteen family), e.g. common St. Johnswort
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
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- Natural Medicines & Medicinal Plants (AREA)
- Animal Behavior & Ethology (AREA)
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- Mycology (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Medical Informatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Alternative & Traditional Medicine (AREA)
- Birds (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
Les fruits de la plante Garcinia cambogia sont utilisés dans la cuisineThe fruits of the Garcinia cambogia plant are used in cooking
indienne traditionelle. On leur attribue des proprietés toniques, stimulantes. Les feuilles d'Hibiscus cannabinus vulgaris L, plante du Madagascar, n'ont pas d'application connue. traditional Indian. They are attributed with invigorating, stimulating properties. The leaves of Hibiscus cannabinus vulgaris L, a plant from Madagascar, have no known application.
L'objet du présent brevet est la découverte que les extraits obtenus à partir de ces plantes, surtout des fruits et particulièrement des écorces des fruits de Garcinia, et des feuilles d'Hibiscus, possèdent des activités biochimiques utiles pour l'application cosmétique et dermopharmaceutique. Il est décrit (R.N. Rao et al. in Nutrition Research, 1988, Vol. 8, pp. 209-212) que l'hydroxycitrate, principal acide contenu dans le fruit de Garcinia (que l'on retrouve également dans les feuilles d'Hibiscus), possède le pouvoir d'inhibition de certaines enzymes impliquées dans la lipogénèse, en particulier 1' ATP:citrate lyase (EC 4. 5.3.8). The object of this patent is the discovery that the extracts obtained from these plants, especially fruits and especially the bark of Garcinia fruits, and Hibiscus leaves, have biochemical activities useful for cosmetic and dermopharmaceutical application . It is described (RN Rao et al. In Nutrition Research, 1988, Vol. 8, pp. 209-212) that hydroxycitrate, the main acid contained in the fruit of Garcinia (which is also found in the leaves of Hibiscus), has the power to inhibit certain enzymes involved in lipogenesis, in particular 1 ATP: citrate lyase (EC 4. 5.3.8).
Les extraits de Garcinia cambogia ou d'Hibiscus cannabinus vulgaris L objets du présent brevet peuvent donc être utilisés dans le domaine de la cosmétique, surtout pour l'application anticellulitique, amincissante, anti-capitons, raffermissante. The extracts of Garcinia cambogia or Hibiscus cannabinus vulgaris The objects of this patent can therefore be used in the field of cosmetics, especially for the anti-cellulite, slimming, anti-dimpling, firming application.
A titre d'exemple nous décrivons une extraction de Garcinia cambogia qui peut être industrialisée à faible coût: g d'écorce sèche de fruit de Garcinia cambogia sont broyés, puis macérés pendant 24 heures dans 1500 ml d'un mélange d'eau et de glycérine à 40 C. Après filtration on récupère un filtrat rose, limpide, de pH acide (pH < 3) que l'on concentre sous vide à 100 mi. On neutralise à la soude puis l'on chauffe à 80 C pendant 30 minutes pour transformer toute la lactone présente en sel trisodique. As an example, we describe an extraction of Garcinia cambogia which can be industrialized at low cost: g of dry bark of Garcinia cambogia fruit are ground, then macerated for 24 hours in 1500 ml of a mixture of water and glycerin at 40 C. After filtration, a pink, clear filtrate with an acidic pH (pH <3) is recovered which is concentrated under vacuum to 100 ml. It is neutralized with sodium hydroxide and then heated at 80 ° C. for 30 minutes to transform all the lactone present into trisodium salt.
Pour certaines applications il peut s'avérer utile de préparer un extrait sec à partir de l'extrait liquide. Ceci peut être réalisé par les techniques classiques de séchage, d'évaporation, d'atomisation ou de lyophilisation. For certain applications it may prove useful to prepare a dry extract from the liquid extract. This can be achieved by conventional drying, evaporation, atomization or lyophilization techniques.
Pour précipiter l'hydroxycitrate pur, on ajoute 5 fois le volume en éthanol et on lave le précipité à l'éthanol, puis on sèche sous vide. To precipitate pure hydroxycitrate, 5 times the volume of ethanol is added and the precipitate is washed with ethanol, then dried under vacuum.
Néanmoins, pour l'application cosmétique, on peut se contenter de l'extrait filtré, concentré à convenance, neutralisé et décoloré selon les méthodes standards. However, for the cosmetic application, one can be satisfied with the filtered extract, concentrated to suit, neutralized and discolored according to standard methods.
Les solvants d'extraction peuvent être choisis parmi l'eau, les mélanges glycérine/eau, propylène glycol/eau, butylène glycolleau. The extraction solvents can be chosen from water, glycerin / water mixtures, propylene glycol / water, butylene glycolleau.
L'exemple donné de fabrication de l'extrait n'est pas limitatif. Les améliorations, optimisations et modifications du procédé envisageables sont évidentes pour l'homme de l'art. A la place de la macération simple, on peut employer des techniques à contre courant, la décoction, la lixiviation, l'extractlon à l'aide d'ultrasons, de micro-ondes associées ou non aux solvants. The example given for making the extract is not limiting. The conceivable improvements, optimizations and modifications of the process are obvious to those skilled in the art. Instead of simple maceration, countercurrent techniques can be used, decoction, leaching, extraction using ultrasound, microwaves, whether or not combined with solvents.
L'activité biochimique la plus évidente de l'extrait est le pouvoir inhibiteur de l'enzyme ATP:citrate lyase et donc l'inhibition de la lipogénèse. The most obvious biochemical activity of the extract is the inhibitory power of the ATP enzyme: citrate lyase and therefore the inhibition of lipogenesis.
Cette activité est particulièrement intéressante quand elle est associée à des substances lipolytiques ou favorisant la lipolyse (lipases, caféine, mucopolysaccharides, carnitine). This activity is particularly interesting when it is associated with lipolytic substances or promoting lipolysis (lipases, caffeine, mucopolysaccharides, carnitine).
Les extraits ainsi obtenus peuvent être employés dans les produits cosmétiques et dermopharmaceutiques de toute sorte. The extracts thus obtained can be used in cosmetic and dermopharmaceutical products of all kinds.
De telles compositions présentent des activités anti-cellulitique, favorisent la lipolyse et/ou régulent la lipogénèse, le renouvellement cellulaire cutané, et protègent contre la chute des cheveux. Such compositions have anti-cellulite activities, promote lipolysis and / or regulate lipogenesis, skin cell renewal, and protect against hair loss.
Leur utilisation principale est la cosmétique de soin anti cellulitique, amincissante, raffermissante et antiséborrhéique. En outre, les effets toniques de l'extrait contribuent à une restructuration de l'épiderme, améliorent l'aspect de la peau, diminuent la microcirculation capillaire, donnent élasticité et fermeté aux peaux fatiguées. Their main use is anti-cellulite, slimming, firming and antiseborrheic skincare cosmetics. In addition, the tonic effects of the extract contribute to a restructuring of the epidermis, improve the appearance of the skin, decrease capillary microcirculation, give elasticity and firmness to tired skin.
Les extraits de Garcinia cambogia ou d'Hibiscus cannabinus vulgaris L objets du brevet peuvent trouver également application dans les traitements du cuir chevelu (anti-pelliculaire) et de la peau acnéique. The extracts of Garcinia cambogia or Hibiscus cannabinus vulgaris The subject of the patent can also find application in the treatment of the scalp (anti-dandruff) and acne-prone skin.
Les extraits de Garcinia cambogia ou d'Hibiscus cannabinus vulgaris L objet du présent brevet peuvent être utilisés dans toute forme galénique employée en cosmétique: émulsions H/E et E/H, laits, lotions, gels, pommades, huiles corporelles, lotions capillaires, shampooings, savons, sticks et crayons, sprays, sans que cette liste soit limitative. The extracts of Garcinia cambogia or Hibiscus cannabinus vulgaris The subject of this patent can be used in any dosage form used in cosmetics: O / W and W / O emulsions, milks, lotions, gels, ointments, body oils, hair lotions, shampoos, soaps, sticks and pencils, sprays, without this list being exhaustive.
Il est possible d'incorporer les extraits de Garcinia cambogia ou d'Hibiscus cannabinus vulgaris L décrits, dans des vecteurs cosmétiques comme les liposomes, les chylomicrons, les macro-, micro- et nanoparticules ainsi que les macro-, micro- et nanocapsules, de les absorber sur des polymères organiques poudreux, les talcs, bentonites et autres supports minéraux. It is possible to incorporate the extracts of Garcinia cambogia or of Hibiscus cannabinus vulgaris L described, in cosmetic vectors such as liposomes, chylomicrons, macro-, micro- and nanoparticles as well as macro-, micro- and nanocapsules, absorb them on powdery organic polymers, talcs, bentonites and other mineral supports.
La concentration d'utilisation de ces extraits de Garcinia carnbogia ou d'Hibiscus cannabinus vulgaris L peut varier entre 0.01 et 50% (p/p), préférentiellement entre 0.5 et 10% dans le produit fini. En dessous de ces valeurs, les effets sont négligeables, en dessus il est difficile de formuler un produit cosmétique The concentration of use of these extracts of Garcinia carnbogia or Hibiscus cannabinus vulgaris L can vary between 0.01 and 50% (w / w), preferably between 0.5 and 10% in the finished product. Below these values, the effects are negligible, above it is difficult to formulate a cosmetic product
acceptable.acceptable.
Les extraits de Garcinia cambogia ou d'Hibiscus cannabinus vulgaris L peuvent être combinés dans les compositions cosmétiques avec tout autre ingrédient habituellement utilisé en cosmétique: lipides d'extraction et/ou de synthèse, polymères gélifiants et viscosants, tensioactifs et émulsifiants, principes actifs hydro- ou liposolubles, extraits d'autres plantes, extraits tissulaires, extraits marins. Garcinia cambogia or Hibiscus cannabinus vulgaris L extracts can be combined in cosmetic compositions with any other ingredient usually used in cosmetics: extraction and / or synthetic lipids, gelling and viscosifying polymers, surfactants and emulsifiers, hydro active ingredients - or fat-soluble, extracts from other plants, tissue extracts, marine extracts.
Claims (11)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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FR9401956A FR2716374B1 (en) | 1994-02-18 | 1994-02-18 | New cosmetic or dermopharmaceutical compositions containing plant extracts. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9401956A FR2716374B1 (en) | 1994-02-18 | 1994-02-18 | New cosmetic or dermopharmaceutical compositions containing plant extracts. |
Publications (2)
Publication Number | Publication Date |
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FR2716374A1 true FR2716374A1 (en) | 1995-08-25 |
FR2716374B1 FR2716374B1 (en) | 1996-04-19 |
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Application Number | Title | Priority Date | Filing Date |
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FR9401956A Expired - Fee Related FR2716374B1 (en) | 1994-02-18 | 1994-02-18 | New cosmetic or dermopharmaceutical compositions containing plant extracts. |
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Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2106689A1 (en) * | 1996-04-18 | 1997-11-01 | Cabo Soler Jose | New formulation based on hydroxycitric acid (salts and derivatives) and the cosmetic and pharmaceutical applications thereof by the percutaneous topical route. |
FR2754820A1 (en) * | 1996-10-22 | 1998-04-24 | Ravi Shrivastava | MAGNESIUM (-) HYDROXYCITRATE, PREPARATION METHOD, APPLICATIONS, AND PARTICULARLY PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME |
FR2801789A1 (en) * | 1999-12-02 | 2001-06-08 | Clarins Lab | Compositions comprise keratolin, a lipogenesis inhibitor and excipients for topical application, have a slimming effects on the face |
EP1402886A1 (en) * | 2001-05-28 | 2004-03-31 | Kanebo, Limited | Lipolysis accelerator, cosmetic skin preparation for body weight reduction and food or beverage composition each containing the same, and method for reducing body weight and medicinal use each based on activity of the same |
WO2004074216A2 (en) * | 2003-02-21 | 2004-09-02 | Vama Farmacosmetica S.R.L. | Carnitine salt, preliposome which contains it and dermo-cosmetic formula for topical use based upon said carnitine salt |
EP1502598A2 (en) * | 2003-07-29 | 2005-02-02 | Kao Corporation | Lipolysis stimulator |
WO2006033476A1 (en) * | 2004-09-24 | 2006-03-30 | Showa Denko K.K. | Hydroxycitric acid derivatives and skin external preparations containing the same |
US7025985B2 (en) | 2001-05-28 | 2006-04-11 | Kanebo, Ltd. | Dihydroxyphenyl compounds and glucoside compounds thereof |
WO2007135083A1 (en) | 2006-05-22 | 2007-11-29 | Beiersdorf | Preparations for sebum reduction with a content of hydroxycitrate as active principle |
WO2011128339A1 (en) * | 2010-04-12 | 2011-10-20 | Dsm Ip Assets B.V. | Hair treatment composition containing gambogic acid, ester or amide |
CN113249512A (en) * | 2021-05-28 | 2021-08-13 | 广西壮族自治区农业科学院 | Method for identifying different cytoplasms of kenaf based on difference of mitochondrial gene transcripts and application |
Citations (4)
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DE2052131A1 (en) * | 1969-10-29 | 1971-05-06 | F Hoffmann La Roche & Co AG, Ba sei (Schweiz) | preparation |
US3764692A (en) * | 1970-09-30 | 1973-10-09 | Hoffmann La Roche | Method of treating obesity |
US4511555A (en) * | 1982-09-27 | 1985-04-16 | Faust Valerie F | Herbal hair treatment compositions |
WO1992016184A1 (en) * | 1991-03-15 | 1992-10-01 | Aarhus Oliefabrik A/S | Fat compositions and their use in cosmetic and pharmaceutical emulsion products |
-
1994
- 1994-02-18 FR FR9401956A patent/FR2716374B1/en not_active Expired - Fee Related
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
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DE2052131A1 (en) * | 1969-10-29 | 1971-05-06 | F Hoffmann La Roche & Co AG, Ba sei (Schweiz) | preparation |
US3764692A (en) * | 1970-09-30 | 1973-10-09 | Hoffmann La Roche | Method of treating obesity |
US4511555A (en) * | 1982-09-27 | 1985-04-16 | Faust Valerie F | Herbal hair treatment compositions |
WO1992016184A1 (en) * | 1991-03-15 | 1992-10-01 | Aarhus Oliefabrik A/S | Fat compositions and their use in cosmetic and pharmaceutical emulsion products |
Cited By (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2106689A1 (en) * | 1996-04-18 | 1997-11-01 | Cabo Soler Jose | New formulation based on hydroxycitric acid (salts and derivatives) and the cosmetic and pharmaceutical applications thereof by the percutaneous topical route. |
FR2754820A1 (en) * | 1996-10-22 | 1998-04-24 | Ravi Shrivastava | MAGNESIUM (-) HYDROXYCITRATE, PREPARATION METHOD, APPLICATIONS, AND PARTICULARLY PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME |
WO1998017671A1 (en) * | 1996-10-22 | 1998-04-30 | Ravi Shrivastava | Magnesium (-)hydroxycitrate, method of preparation, applications, and compositions in particular pharmaceutical containing same |
US6221901B1 (en) * | 1996-10-22 | 2001-04-24 | Ravi Shrivastava | Magnesium (-)hydroxycitrate, method of preparation, applications, and compositions in particular pharmaceutical containing same |
FR2801789A1 (en) * | 1999-12-02 | 2001-06-08 | Clarins Lab | Compositions comprise keratolin, a lipogenesis inhibitor and excipients for topical application, have a slimming effects on the face |
US7025985B2 (en) | 2001-05-28 | 2006-04-11 | Kanebo, Ltd. | Dihydroxyphenyl compounds and glucoside compounds thereof |
EP1402886A1 (en) * | 2001-05-28 | 2004-03-31 | Kanebo, Limited | Lipolysis accelerator, cosmetic skin preparation for body weight reduction and food or beverage composition each containing the same, and method for reducing body weight and medicinal use each based on activity of the same |
EP1402886A4 (en) * | 2001-05-28 | 2004-10-06 | Kanebo Ltd | Lipolysis accelerator, cosmetic skin preparation for body weight reduction and food or beverage composition each containing the same, and method for reducing body weight and medicinal use each based on activity of the same |
US7879347B2 (en) | 2001-05-28 | 2011-02-01 | Kao Corporation | Dihydroxyphenyl compounds and glucoside compounds thereof |
WO2004074216A2 (en) * | 2003-02-21 | 2004-09-02 | Vama Farmacosmetica S.R.L. | Carnitine salt, preliposome which contains it and dermo-cosmetic formula for topical use based upon said carnitine salt |
WO2004074216A3 (en) * | 2003-02-21 | 2004-11-04 | Vama Farmacosmetica S R L | Carnitine salt, preliposome which contains it and dermo-cosmetic formula for topical use based upon said carnitine salt |
EP1502598A3 (en) * | 2003-07-29 | 2005-03-30 | Kao Corporation | Lipolysis stimulator |
US7300675B2 (en) | 2003-07-29 | 2007-11-27 | Kao Corporation | Lipolysis stimulator |
EP1502598A2 (en) * | 2003-07-29 | 2005-02-02 | Kao Corporation | Lipolysis stimulator |
WO2006033476A1 (en) * | 2004-09-24 | 2006-03-30 | Showa Denko K.K. | Hydroxycitric acid derivatives and skin external preparations containing the same |
US7846970B2 (en) | 2004-09-24 | 2010-12-07 | Showa Denko K.K. | Hydroxycitric acid derivatives and skin external preparations containing the same |
WO2007135083A1 (en) | 2006-05-22 | 2007-11-29 | Beiersdorf | Preparations for sebum reduction with a content of hydroxycitrate as active principle |
WO2011128339A1 (en) * | 2010-04-12 | 2011-10-20 | Dsm Ip Assets B.V. | Hair treatment composition containing gambogic acid, ester or amide |
CN102844017A (en) * | 2010-04-12 | 2012-12-26 | 帝斯曼知识产权资产管理有限公司 | Hair treatment composition containing gambogic acid, ester or amide |
US20130195777A1 (en) * | 2010-04-12 | 2013-08-01 | Dsm Ip Assts B.V. | Hair treatment composition containing gambogic acid, ester or amide |
CN102844017B (en) * | 2010-04-12 | 2015-10-21 | 帝斯曼知识产权资产管理有限公司 | Hair care composition containing gamlogic acid, Resina garciniae acid esters or Resina garciniae amide |
US9445979B2 (en) | 2010-04-12 | 2016-09-20 | Dsm Ip Assets B.V. | Hair treatment composition containing gambogic acid, ester or amide |
CN113249512A (en) * | 2021-05-28 | 2021-08-13 | 广西壮族自治区农业科学院 | Method for identifying different cytoplasms of kenaf based on difference of mitochondrial gene transcripts and application |
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Publication number | Publication date |
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FR2716374B1 (en) | 1996-04-19 |
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