WO1999009053A1 - Derives de phenylethylamine - Google Patents

Derives de phenylethylamine Download PDF

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Publication number
WO1999009053A1
WO1999009053A1 PCT/JP1998/003627 JP9803627W WO9909053A1 WO 1999009053 A1 WO1999009053 A1 WO 1999009053A1 JP 9803627 W JP9803627 W JP 9803627W WO 9909053 A1 WO9909053 A1 WO 9909053A1
Authority
WO
WIPO (PCT)
Prior art keywords
group
carbon atoms
tbu
substituent
linear
Prior art date
Application number
PCT/JP1998/003627
Other languages
English (en)
French (fr)
Japanese (ja)
Inventor
Ken-Ichiro Kotake
Toshiro Kozono
Tsutomu Sato
Hisanori Takanashi
Original Assignee
Chugai Seiyaku Kabushiki Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Seiyaku Kabushiki Kaisha filed Critical Chugai Seiyaku Kabushiki Kaisha
Priority to CA002301687A priority Critical patent/CA2301687A1/en
Priority to EP98937826A priority patent/EP1006122B1/en
Priority to DE69840296T priority patent/DE69840296D1/de
Priority to KR1020007001529A priority patent/KR20010022924A/ko
Priority to AU86490/98A priority patent/AU741216B2/en
Priority to US09/485,620 priority patent/US6255285B1/en
Publication of WO1999009053A1 publication Critical patent/WO1999009053A1/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0819—Tripeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
PCT/JP1998/003627 1997-08-15 1998-08-14 Derives de phenylethylamine WO1999009053A1 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA002301687A CA2301687A1 (en) 1997-08-15 1998-08-14 Phenethylamine derivatives
EP98937826A EP1006122B1 (en) 1997-08-15 1998-08-14 Phenethylamine derivatives
DE69840296T DE69840296D1 (de) 1997-08-15 1998-08-14 Phenylethylenamin-derivate
KR1020007001529A KR20010022924A (ko) 1997-08-15 1998-08-14 페네틸아민 유도체
AU86490/98A AU741216B2 (en) 1997-08-15 1998-08-14 Phenethylamine derivatives
US09/485,620 US6255285B1 (en) 1997-08-15 1998-08-14 Phenethylamine derivatives

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP9/255879 1997-08-15
JP25587997 1997-08-15
JP10/186802 1998-05-28
JP18680298 1998-05-28

Publications (1)

Publication Number Publication Date
WO1999009053A1 true WO1999009053A1 (fr) 1999-02-25

Family

ID=26503986

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1998/003627 WO1999009053A1 (fr) 1997-08-15 1998-08-14 Derives de phenylethylamine

Country Status (10)

Country Link
US (1) US6255285B1 (US06255285-20010703-C00126.png)
EP (1) EP1006122B1 (US06255285-20010703-C00126.png)
KR (1) KR20010022924A (US06255285-20010703-C00126.png)
CN (1) CN1272114A (US06255285-20010703-C00126.png)
AT (1) ATE416186T1 (US06255285-20010703-C00126.png)
AU (1) AU741216B2 (US06255285-20010703-C00126.png)
CA (1) CA2301687A1 (US06255285-20010703-C00126.png)
DE (1) DE69840296D1 (US06255285-20010703-C00126.png)
TW (1) TW460478B (US06255285-20010703-C00126.png)
WO (1) WO1999009053A1 (US06255285-20010703-C00126.png)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000017231A1 (fr) * 1998-09-24 2000-03-30 Chugai Seiyaku Kabushiki Kaisha Derives d'ethylamine
WO2000044770A1 (fr) * 1999-01-28 2000-08-03 Chugai Seiyaku Kabushiki Kaisha Derives phenethylamine substitues
WO2001085694A2 (en) * 2000-05-05 2001-11-15 Ortho-Mcneil Pharmaceutical, Inc. Substituted diamide derivatives useful as motilin antagonists
WO2002059141A1 (fr) * 2001-01-25 2002-08-01 Chugai Seiyaku Kabushiki Kaisha Derives peptidiques
KR100342762B1 (ko) * 1993-06-28 2002-11-18 와이어쓰 활성성분으로서치환된펜에틸아민을포함하는약제학적조성물
EP1510515A1 (en) 2000-06-13 2005-03-02 Eli Lilly And Company Phenylglycine derivatives as serine protease inhibitors
EP2431380A2 (en) 2006-09-11 2012-03-21 Tranzyme Pharma, Inc. Macrocyclic antagonist of the motilin receptor for treatment of gastrointestinal dysmotility disorders

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6329372B1 (en) * 1998-01-27 2001-12-11 Celltech Therapeutics Limited Phenylalanine derivatives
US6716452B1 (en) 2000-08-22 2004-04-06 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
WO2002016404A1 (fr) * 2000-08-24 2002-02-28 Chugai Seiyaku Kabushiki Kaisha Derive de peptide cyclique
US8394813B2 (en) 2000-11-14 2013-03-12 Shire Llc Active agent delivery systems and methods for protecting and administering active agents
WO2002057791A2 (en) * 2000-11-29 2002-07-25 Lifespan Biosciences, Inc. Diagnostic and therapeutic compositions and methods related to grp 38
EP1383799A4 (en) * 2001-04-10 2008-08-06 Transtech Pharma Inc PROBES, SYSTEMS AND METHODS FOR DISCOVERING MEDICAMENTS
AU2002307839B2 (en) 2001-06-28 2006-03-16 Zoetis P Llc Triamide-substituted indoles, benzofuranes and benzothiophenes as inhibitors of microsomal triglyceride transfer protein (MTP) and/or apolipoprotein B (Apo B) secretion
US7375082B2 (en) * 2002-02-22 2008-05-20 Shire Llc Abuse-resistant hydrocodone compounds
US20060014697A1 (en) * 2001-08-22 2006-01-19 Travis Mickle Pharmaceutical compositions for prevention of overdose or abuse
US7338939B2 (en) * 2003-09-30 2008-03-04 New River Pharmaceuticals Inc. Abuse-resistant hydrocodone compounds
US7169752B2 (en) * 2003-09-30 2007-01-30 New River Pharmaceuticals Inc. Compounds and compositions for prevention of overdose of oxycodone
US20070066537A1 (en) * 2002-02-22 2007-03-22 New River Pharmaceuticals Inc. Compounds and compositions for prevention of overdose of oxycodone
EP1469875A1 (en) * 2002-01-29 2004-10-27 Wyeth Compositions and methods for modulating connexin hemichannels
US7659253B2 (en) * 2002-02-22 2010-02-09 Shire Llc Abuse-resistant amphetamine prodrugs
KR20050010756A (ko) * 2002-02-22 2005-01-28 뉴 리버 파마슈티칼스, 인크. 피험자 간 약물 혈청 농도의 변동성을 감소시키기 위한펩티드-약물 접합체의 용도
US7105486B2 (en) * 2002-02-22 2006-09-12 New River Pharmaceuticals Inc. Abuse-resistant amphetamine compounds
US7700561B2 (en) * 2002-02-22 2010-04-20 Shire Llc Abuse-resistant amphetamine prodrugs
ES2500117T3 (es) * 2002-02-22 2014-09-30 Shire Llc Novedosos compuestos farmacéuticos de liberación sostenida para prevenir el abuso de sustancias controladas
PT1644019E (pt) * 2003-05-29 2012-05-23 Shire Llc Compostos de anfetamina resistentes ao abuso
WO2004111077A1 (en) 2003-06-18 2004-12-23 Tranzyme Pharma Inc. Macrocyclic antagonists of the motilin receptor
CA2540678C (en) * 2003-09-30 2011-02-22 New River Pharmaceuticals Inc. Pharmaceutical compositions for prevention of overdose or abuse
US20080287371A1 (en) * 2007-05-17 2008-11-20 Tranzyme Pharma Inc. Macrocyclic antagonists of the motilin receptor for modulation of the migrating motor complex
EP3370518B1 (en) 2015-10-14 2023-08-23 X-Therma, Inc. Compositions and methods for reducing ice crystal formation
CN112812334B (zh) * 2021-01-11 2022-06-17 浙江博菲电气股份有限公司 一种新能源电机用阻燃槽楔的制备工艺及阻燃槽楔

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994003483A1 (en) * 1992-07-30 1994-02-17 Chiron Corporation Endothelin receptor-binding compounds
WO1996040208A1 (en) * 1995-06-07 1996-12-19 Torrey Pines Institute For Molecular Studies Novel mu opioid receptor ligands: agonists and antagonists

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5470830A (en) 1993-08-06 1995-11-28 Ohmeda Pharmaceutical Products Division Inc. Motilin-like polypeptides that inhibit gastrointestinal motor activity
JP3449766B2 (ja) 1993-11-19 2003-09-22 中外製薬株式会社 モチリンアンタゴニスト
US5712253A (en) 1996-06-18 1998-01-27 Abbott Laboratories Macrocyclic 13-membered ring derivatives of erythromycins A and B
US6013633A (en) * 1997-08-07 2000-01-11 University Of Cincinnati Compounds for control of appetite, blood pressure, cardiovascular response, libido, and circadian rhythm
US5972939A (en) 1997-10-28 1999-10-26 Ortho-Mcneil Pharmaceutical, Inc. Cyclopentene derivatives useful as antagonists of the motilin receptor
EP1149843A4 (en) * 1999-01-28 2012-06-06 Chugai Pharmaceutical Co Ltd SUBSTITUTED PHENETHYLAMINE DERIVATIVES

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994003483A1 (en) * 1992-07-30 1994-02-17 Chiron Corporation Endothelin receptor-binding compounds
WO1996040208A1 (en) * 1995-06-07 1996-12-19 Torrey Pines Institute For Molecular Studies Novel mu opioid receptor ligands: agonists and antagonists

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DEPOORTERE I., ET AL.: "ANTAGONISTIC PROPERTIES OF ÚPHE3,LEU13¾PORCINE MOTILIN.", EUROPEAN JOURNAL OF PHARMACOLOGY, ELSEVIER SCIENCE, NL, vol. 286., 1 January 1995 (1995-01-01), NL, pages 241 - 247., XP002913859, ISSN: 0014-2999, DOI: 10.1016/0014-2999(95)00453-5 *
POITRAS, P., ET AL.: "MOTILIN SYNTHETIC ANALOGUES AND MOTILIN RECEPTOR ANTAGONISTS.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 205., no. 01., 1 January 1994 (1994-01-01), US, pages 449 - 454., XP002913858, ISSN: 0006-291X, DOI: 10.1006/bbrc.1994.2686 *
TAKANASHI H., ET AL.: "GM-109: A NOVEL, SELECTIVE MOTILIN RECEPTOR ANTAGONIST IN THE SMOOTH MUSCLE OF THE RABBIT SMALL INTESTINE.", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, AMERICAN SOCIETY FOR PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, US, vol. 273., no. 02., 1 January 1995 (1995-01-01), US, pages 624 - 628., XP002913857, ISSN: 0022-3565 *

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100342762B1 (ko) * 1993-06-28 2002-11-18 와이어쓰 활성성분으로서치환된펜에틸아민을포함하는약제학적조성물
WO2000017231A1 (fr) * 1998-09-24 2000-03-30 Chugai Seiyaku Kabushiki Kaisha Derives d'ethylamine
US6586630B1 (en) * 1998-09-24 2003-07-01 Chugai Seiyaku Kabushiki Kaisha Ethylamine derivatives
WO2000044770A1 (fr) * 1999-01-28 2000-08-03 Chugai Seiyaku Kabushiki Kaisha Derives phenethylamine substitues
EP1149843A4 (en) * 1999-01-28 2012-06-06 Chugai Pharmaceutical Co Ltd SUBSTITUTED PHENETHYLAMINE DERIVATIVES
US7553969B1 (en) * 1999-01-28 2009-06-30 Chugai Seiyaku Kabushiki Kaisha Substituted phenethylamine derivatives
US6511980B2 (en) 2000-05-05 2003-01-28 Ortho Mcneil Pharmaceutical, Inc. Substituted diamine derivatives useful as motilin antagonists
US6967199B2 (en) 2000-05-05 2005-11-22 Ortho-Mcneil Pharmaceutical, Inc. Substituted diamine derivatives useful as motilin antagonists
US7112586B2 (en) 2000-05-05 2006-09-26 Ortho-Mcneil Pharmaceutical, Inc. Substituted diamine derivatives useful as motilin antagonists
US7166601B2 (en) 2000-05-05 2007-01-23 Ortho-Mcneil Pharmaceutical, Inc. Substituted diamine derivatives useful as motilin antagonists
WO2001085694A3 (en) * 2000-05-05 2002-04-04 Ortho Mcneil Pharm Inc Substituted diamide derivatives useful as motilin antagonists
WO2001085694A2 (en) * 2000-05-05 2001-11-15 Ortho-Mcneil Pharmaceutical, Inc. Substituted diamide derivatives useful as motilin antagonists
EP1510515A1 (en) 2000-06-13 2005-03-02 Eli Lilly And Company Phenylglycine derivatives as serine protease inhibitors
WO2002059141A1 (fr) * 2001-01-25 2002-08-01 Chugai Seiyaku Kabushiki Kaisha Derives peptidiques
EP2431380A2 (en) 2006-09-11 2012-03-21 Tranzyme Pharma, Inc. Macrocyclic antagonist of the motilin receptor for treatment of gastrointestinal dysmotility disorders

Also Published As

Publication number Publication date
AU8649098A (en) 1999-03-08
EP1006122A1 (en) 2000-06-07
US6255285B1 (en) 2001-07-03
TW460478B (en) 2001-10-21
CN1272114A (zh) 2000-11-01
AU741216B2 (en) 2001-11-29
CA2301687A1 (en) 1999-02-25
ATE416186T1 (de) 2008-12-15
EP1006122B1 (en) 2008-12-03
DE69840296D1 (de) 2009-01-15
KR20010022924A (ko) 2001-03-26
EP1006122A4 (en) 2004-10-13

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