WO1999006029A1 - Formulierung auf der basis von ascorbinsäure mit verbesserter farbstabilität - Google Patents
Formulierung auf der basis von ascorbinsäure mit verbesserter farbstabilität Download PDFInfo
- Publication number
- WO1999006029A1 WO1999006029A1 PCT/EP1998/004556 EP9804556W WO9906029A1 WO 1999006029 A1 WO1999006029 A1 WO 1999006029A1 EP 9804556 W EP9804556 W EP 9804556W WO 9906029 A1 WO9906029 A1 WO 9906029A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- preparation according
- weight
- ascorbic acid
- cellulose
- sugar alcohols
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/346—Finished or semi-finished products in the form of powders, paste or liquids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G2200/00—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF containing organic compounds, e.g. synthetic flavouring agents
- A23G2200/04—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF containing organic compounds, e.g. synthetic flavouring agents containing vitamins, antibiotics, other medicaments
Definitions
- the invention relates to a new formulation based on ascorbic acid with an improved taste, which is directly compressible and has an improved color stability.
- lozenges and especially chewable tablets are increasingly being offered in the area of nutritional supplements (vitamin and mineral supplementation). Furthermore, one tries to produce solid ones
- Formulations increasingly use directly compressible active ingredients (DC active ingredients) in order to reduce production costs.
- DC active ingredients directly compressible active ingredients
- the invention thus relates to preparations containing ascorbic acid in a directly compressible form with an improved taste.
- the invention therefore also relates to a process for the preparation of ascorbic acid-containing solid preparations in directly compressible form with an improved taste, characterized in that a) an aqueous solution is prepared containing
- the invention furthermore relates to formulations which contain directly compressible ascorbic acid and which, in addition to at least one sugar alcohol, contain up to 1.5% by weight of one or more binders from the group cellulose, methyl cellulose, hydroxymethyl propyl cellulose, carboxymethyl cellulose, starch, maltodextrin and gum arabic.
- the total amount of sugar alcohol used is to be selected so that 1.5 to 15% by weight, in particular 2 to 10% by weight, are present in the pulverulent substance mixture produced by the process according to the invention.
- sugar alcohols from the group C 4 - C12 sugar alcohols are suitable for the preparation of the preparations containing ascorbic acid.
- Particularly suitable sugar alcohols are in particular those from the group of erythritol, xylitol, mannitol and lactitol.
- Lactitol based on 0.5 to 2.0 parts of sorbitol may be included.
- composition according to the invention is therefore obtainable by dissolving at least one sugar alcohol in water and dissolving or suspending the ascorbic acid and spraying the aqueous mixture obtained in an air stream at a temperature of from room temperature to 180 ° C., preferably 60 to 140 ° C., drawing off air streams containing steam, and fluidized bed treatment, the fluidized bed having a low and variable height.
- the homogeneous particles that form are discharged in solid form. Up to 1% by weight of the particles formed are returned to the process.
- solid dosage forms can be produced directly from the preparations according to the invention described above without further processing, such as, for. B. Compresses.
- the solid ascorbic acid preparations obtainable by spray granulation or spray fluidized bed granulation can also be mixed in a simple manner with one or more active ingredients and processed into tablet formulations.
- these formulations can be processed into products that can be sold to the customer for self-medication.
- These include, among other things, pain relievers in tablet form, cold remedies, such as throat tablets and lozenges. In such lozenges, the improved properties are noticeable by a smoother surface not only immediately after production, but also during sucking.
- formulations according to the invention can be incorporated particularly advantageously into corresponding chewable tablets, since on the one hand they can be compressed without much energy expenditure, and on the other hand lead to improved chewing behavior due to the improved taste profile.
- the preparations according to the invention can also be used to produce food supplements in a simple manner, both in tablet form and in any other manner known to the person skilled in the art.
- the powdery, directly compressible ascorbic acid preparations can also be incorporated into a wide variety of confectionery products, such as lozenges, chewing gum or other confectionery products
- the ascorbic acid formulations according to the invention in addition to an improved taste and direct compressibility, also lead to better storage stability of the products produced.
- tablet formulations in which ascorbic acid is contained and to which binders have been added in order to achieve sufficient tablet hardness tend to yellow.
- corresponding products which are manufactured using the preparations according to the invention have no discoloration, even after storage for several months. This is particularly the case if non-hygroscopic sugar alcohols, such as mannitol, are used to prepare the preparations. Satisfactory tablet hardness is also achieved without the addition of binders.
- products are obtained which have reduced abrasion in experiments.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Nutrition Science (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physiology (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Confectionery (AREA)
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98943755A EP1007007A1 (de) | 1997-07-31 | 1998-07-21 | Formulierung auf der basis von ascorbinsäure mit verbesserter farbstabilität |
JP2000504844A JP2001511442A (ja) | 1997-07-31 | 1998-07-21 | 改良された色彩安定性を有するアスコルビン酸を基にした処方物 |
CA002298624A CA2298624A1 (en) | 1997-07-31 | 1998-07-21 | Ascorbic acid-based formulation having improved colour stability |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19733094A DE19733094A1 (de) | 1997-07-31 | 1997-07-31 | Formulierung auf der Basis von Ascorbinsäure mit verbesserter Farbstabilität |
DE19733094.0 | 1997-07-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1999006029A1 true WO1999006029A1 (de) | 1999-02-11 |
Family
ID=7837556
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1998/004556 WO1999006029A1 (de) | 1997-07-31 | 1998-07-21 | Formulierung auf der basis von ascorbinsäure mit verbesserter farbstabilität |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1007007A1 (de) |
JP (1) | JP2001511442A (de) |
CN (1) | CN1265584A (de) |
CA (1) | CA2298624A1 (de) |
DE (1) | DE19733094A1 (de) |
WO (1) | WO1999006029A1 (de) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1110550A2 (de) * | 1999-12-22 | 2001-06-27 | F. Hoffmann-La Roche Ag | Arzneizusammensetzung enthaltend Ascorbinsäure und Pektin |
US8242096B2 (en) | 2001-09-03 | 2012-08-14 | Dsm Ip Assets B.V. | Compositions comprising pectin and ascorbic acid |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE0100824D0 (sv) * | 2001-03-09 | 2001-03-09 | Astrazeneca Ab | Method III to obtain microparticles |
SE0100822D0 (sv) * | 2001-03-09 | 2001-03-09 | Astrazeneca Ab | Method II to obtain microparticles |
DE102008004893A1 (de) * | 2008-01-17 | 2009-07-23 | Add Technologies Ltd. | Trägerpellets, Verfahren zu deren Herstellung und deren Verwendung |
EP3770145A1 (de) | 2019-07-24 | 2021-01-27 | Basf Se | Verfahren zur kontinuierlichen herstellung von acrolein oder acrylsäure als zielprodukt aus propen |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3293132A (en) * | 1963-03-25 | 1966-12-20 | Merck & Co Inc | Spray dried vitamin compositions and method of preparation |
DE2616078A1 (de) * | 1975-07-24 | 1977-02-10 | Takeda Chemical Industries Ltd | L-ascorbinsaeuregranulat und -tabletten |
US4203997A (en) * | 1977-02-17 | 1980-05-20 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Directly-pressable ascorbic acid-containing granulates |
EP0049143A2 (de) * | 1980-09-30 | 1982-04-07 | Takeda Chemical Industries, Ltd. | Natriumaskorbat-Granulate und deren Herstellung |
EP0198431A2 (de) * | 1985-04-17 | 1986-10-22 | BASF Corporation | Verfahren zum Gleitfähigmachen wasserlöslicher Vitaminpulver |
-
1997
- 1997-07-31 DE DE19733094A patent/DE19733094A1/de not_active Withdrawn
-
1998
- 1998-07-21 CA CA002298624A patent/CA2298624A1/en not_active Abandoned
- 1998-07-21 JP JP2000504844A patent/JP2001511442A/ja active Pending
- 1998-07-21 EP EP98943755A patent/EP1007007A1/de not_active Withdrawn
- 1998-07-21 WO PCT/EP1998/004556 patent/WO1999006029A1/de not_active Application Discontinuation
- 1998-07-21 CN CN98807777A patent/CN1265584A/zh active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3293132A (en) * | 1963-03-25 | 1966-12-20 | Merck & Co Inc | Spray dried vitamin compositions and method of preparation |
DE2616078A1 (de) * | 1975-07-24 | 1977-02-10 | Takeda Chemical Industries Ltd | L-ascorbinsaeuregranulat und -tabletten |
US4203997A (en) * | 1977-02-17 | 1980-05-20 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Directly-pressable ascorbic acid-containing granulates |
EP0049143A2 (de) * | 1980-09-30 | 1982-04-07 | Takeda Chemical Industries, Ltd. | Natriumaskorbat-Granulate und deren Herstellung |
EP0198431A2 (de) * | 1985-04-17 | 1986-10-22 | BASF Corporation | Verfahren zum Gleitfähigmachen wasserlöslicher Vitaminpulver |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1110550A2 (de) * | 1999-12-22 | 2001-06-27 | F. Hoffmann-La Roche Ag | Arzneizusammensetzung enthaltend Ascorbinsäure und Pektin |
EP1110550A3 (de) * | 1999-12-22 | 2001-09-19 | F. Hoffmann-La Roche Ag | Arzneizusammensetzung enthaltend Ascorbinsäure und Pektin |
US6974832B2 (en) | 1999-12-22 | 2005-12-13 | Dsm Nutritional Products Inc. | L-ascorbic acid and pectin composition |
US8242096B2 (en) | 2001-09-03 | 2012-08-14 | Dsm Ip Assets B.V. | Compositions comprising pectin and ascorbic acid |
Also Published As
Publication number | Publication date |
---|---|
CA2298624A1 (en) | 1999-02-11 |
CN1265584A (zh) | 2000-09-06 |
JP2001511442A (ja) | 2001-08-14 |
EP1007007A1 (de) | 2000-06-14 |
DE19733094A1 (de) | 1999-02-04 |
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