WO1999005521A3 - Konjugat zur unterscheidung von krankhaftem und gesundem gewebe - Google Patents

Konjugat zur unterscheidung von krankhaftem und gesundem gewebe Download PDF

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Publication number
WO1999005521A3
WO1999005521A3 PCT/DE1998/002102 DE9802102W WO9905521A3 WO 1999005521 A3 WO1999005521 A3 WO 1999005521A3 DE 9802102 W DE9802102 W DE 9802102W WO 9905521 A3 WO9905521 A3 WO 9905521A3
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WO
WIPO (PCT)
Prior art keywords
differentiating
conjugate
healthy
unhealthy tissue
compound
Prior art date
Application number
PCT/DE1998/002102
Other languages
English (en)
French (fr)
Other versions
WO1999005521A2 (de
Inventor
Hannsjoerg Sinn
Hans-Hermann Schrenk
Andreas Wunder
Gerd Stehle
Original Assignee
Deutsches Krebsforsch
Hannsjoerg Sinn
Schrenk Hans Hermann
Andreas Wunder
Gerd Stehle
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deutsches Krebsforsch, Hannsjoerg Sinn, Schrenk Hans Hermann, Andreas Wunder, Gerd Stehle filed Critical Deutsches Krebsforsch
Priority to EP98946241A priority Critical patent/EP0998674A2/de
Priority to JP2000504456A priority patent/JP2001513583A/ja
Publication of WO1999005521A2 publication Critical patent/WO1999005521A2/de
Publication of WO1999005521A3 publication Critical patent/WO1999005521A3/de

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0026—Acridine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0036—Porphyrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0039—Coumarin dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Die Erfindung betrifft Konjugate, umfassend eine zur Fluoreszenz-fähige Verbindung und einen Träger, wobei die Verbindung und der Träger über eine Säureester- oder Säureamid-Bindung verbunden sind und die Verbindung eine Anregungswellenlänge von 630 nm oder größer und/oder 450 nm oder kleiner aufweist. Ferner betrifft die Erfindung die Herstellung solcher Konjugate sowie ihre Verwendung.
PCT/DE1998/002102 1997-07-23 1998-07-22 Konjugat zur unterscheidung von krankhaftem und gesundem gewebe WO1999005521A2 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP98946241A EP0998674A2 (de) 1997-07-23 1998-07-22 Konjugat zur unterscheidung von krankhaftem und gesundem gewebe
JP2000504456A JP2001513583A (ja) 1997-07-23 1998-07-22 健常組織と非健常組織とを識別する方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19731741A DE19731741A1 (de) 1997-07-23 1997-07-23 Konjugat zur Unterscheidung von krankhaftem und gesundem Gewebe
DE19731741.3 1997-07-23

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/917,907 Continuation US20050019263A1 (en) 1997-07-23 2004-08-13 Conjugate for differentiating between healthy and unhealthy tissue

Publications (2)

Publication Number Publication Date
WO1999005521A2 WO1999005521A2 (de) 1999-02-04
WO1999005521A3 true WO1999005521A3 (de) 1999-04-08

Family

ID=7836699

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1998/002102 WO1999005521A2 (de) 1997-07-23 1998-07-22 Konjugat zur unterscheidung von krankhaftem und gesundem gewebe

Country Status (5)

Country Link
US (2) US20020037254A1 (de)
EP (1) EP0998674A2 (de)
JP (1) JP2001513583A (de)
DE (1) DE19731741A1 (de)
WO (1) WO1999005521A2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19847362A1 (de) * 1998-10-14 2000-04-20 Deutsches Krebsforsch Makromolekulare Wirkstoffkonjugate und Verfahren zu ihrer Herstellung
DE29911689U1 (de) * 1999-07-06 2000-04-06 Sterk Peter Mittel für den Gefässverschluß von organischem Gewebe
DE10006570A1 (de) * 2000-02-14 2001-08-23 Deutsches Krebsforsch Nicht toxisches MR-Kontrastmittel
ATE298341T1 (de) * 2001-03-21 2005-07-15 Molteni & C Metallsubstituierte, nicht zentrosymmetrische phthalocyanin-analoga, deren herstellung und verwendung zur photodynamischen therapie, und als in-vivo-diagnostikum
CA2851344C (en) * 2011-09-05 2017-10-03 Hiroshi Maeda Polymer-type fluorescent molecule probe
JP6552236B2 (ja) 2015-03-23 2019-07-31 キヤノン株式会社 近赤外色素結合トランスフェリン、前記近赤外色素結合トランスフェリンを有する光音響イメージング用造影剤
JP2017128532A (ja) * 2016-01-20 2017-07-27 キヤノン株式会社 光学イメージング用造影剤の製造方法、及び光学イメージング用造影剤
JP6752582B2 (ja) * 2016-02-08 2020-09-09 キヤノン株式会社 光音響イメージング用造影剤

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3248043A1 (de) * 1982-12-24 1984-06-28 Bayer Ag, 5090 Leverkusen Fluorogene phosphorsaeureester, verfahren zu deren herstellung sowie verfahren und mittel zum nachweis und zur fluorometrischen bestimmung von phosphaten
DE3321041A1 (de) * 1983-06-10 1984-12-13 Bayer Ag, 5090 Leverkusen Chromogene und fluorogene ester, verfahren zu deren herstellung sowie verfahren und mittel zum nachweis und zur photometrischen oder fluorometrischen bestimmung von phosphatasen bzw. sulfatasen
EP0142810A2 (de) * 1983-11-10 1985-05-29 Genetic Systems Corporation Integralantikörper enthaltende polymerisierbare Verbindungen und deren Anwendungen in Immuntesten mit durch Polymerisation induzierter Trennung
EP0267038A2 (de) * 1986-11-06 1988-05-11 The University Of British Columbia Effizientere Kopplung in wasserfreien Medien
EP0582456A2 (de) * 1992-08-05 1994-02-09 Hybritech Incorporated Protein-Farbstoff-Konjugate zur Feststellung der korrekten Verdünnung von Kalibratoren
EP0808829A1 (de) * 1996-05-20 1997-11-26 Nisshinbo Industries, Inc. Carbodiimidverbindungen die eine fluoreszierende Gruppe enthalten
FR2757162A1 (fr) * 1996-12-12 1998-06-19 Cis Bio Int Conjugues fluorescents non agreges

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4783529A (en) * 1985-12-03 1988-11-08 Research Corporation Technologies Rapid synthesis of radiolabeled porphyrin complexes for medical application
US4923819A (en) * 1987-03-27 1990-05-08 Chimerix Corporation Time-resolved fluorescence immunoassay
US5612016A (en) * 1988-04-01 1997-03-18 Immunomedics, Inc. Conjugates of antibodies and bifunctional ligands
US4990447A (en) * 1988-06-24 1991-02-05 Gist-Brocades Nv Process for the purification of serum albumin
US5231004A (en) * 1990-05-11 1993-07-27 Eastman Kodak Company Use of heme-containing proteins as stabilizers for enzyme-labeled immunoreactants
IL102645A (en) * 1992-07-26 1998-02-22 Yeda Res & Dev Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them
US5563132A (en) * 1994-06-21 1996-10-08 Bodaness; Richard S. Two-step cancer treatment method

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3248043A1 (de) * 1982-12-24 1984-06-28 Bayer Ag, 5090 Leverkusen Fluorogene phosphorsaeureester, verfahren zu deren herstellung sowie verfahren und mittel zum nachweis und zur fluorometrischen bestimmung von phosphaten
DE3321041A1 (de) * 1983-06-10 1984-12-13 Bayer Ag, 5090 Leverkusen Chromogene und fluorogene ester, verfahren zu deren herstellung sowie verfahren und mittel zum nachweis und zur photometrischen oder fluorometrischen bestimmung von phosphatasen bzw. sulfatasen
EP0142810A2 (de) * 1983-11-10 1985-05-29 Genetic Systems Corporation Integralantikörper enthaltende polymerisierbare Verbindungen und deren Anwendungen in Immuntesten mit durch Polymerisation induzierter Trennung
EP0267038A2 (de) * 1986-11-06 1988-05-11 The University Of British Columbia Effizientere Kopplung in wasserfreien Medien
EP0582456A2 (de) * 1992-08-05 1994-02-09 Hybritech Incorporated Protein-Farbstoff-Konjugate zur Feststellung der korrekten Verdünnung von Kalibratoren
EP0808829A1 (de) * 1996-05-20 1997-11-26 Nisshinbo Industries, Inc. Carbodiimidverbindungen die eine fluoreszierende Gruppe enthalten
FR2757162A1 (fr) * 1996-12-12 1998-06-19 Cis Bio Int Conjugues fluorescents non agreges

Also Published As

Publication number Publication date
US20050019263A1 (en) 2005-01-27
WO1999005521A2 (de) 1999-02-04
JP2001513583A (ja) 2001-09-04
EP0998674A2 (de) 2000-05-10
DE19731741A1 (de) 1999-01-28
US20020037254A1 (en) 2002-03-28

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