WO1998040493A1 - Vaccin anti-vif - Google Patents

Vaccin anti-vif Download PDF

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Publication number
WO1998040493A1
WO1998040493A1 PCT/GB1998/000715 GB9800715W WO9840493A1 WO 1998040493 A1 WO1998040493 A1 WO 1998040493A1 GB 9800715 W GB9800715 W GB 9800715W WO 9840493 A1 WO9840493 A1 WO 9840493A1
Authority
WO
WIPO (PCT)
Prior art keywords
fipv
fiv
polynucleotide
deletion
pol gene
Prior art date
Application number
PCT/GB1998/000715
Other languages
English (en)
Inventor
James Charles Neil
Mark Alan Rigby
James Oswald Jarrett
Original Assignee
The University Court Of The University Of Glasgow
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The University Court Of The University Of Glasgow filed Critical The University Court Of The University Of Glasgow
Priority to JP53935198A priority Critical patent/JP2002501369A/ja
Priority to EP98912585A priority patent/EP1007687A1/fr
Priority to AU67369/98A priority patent/AU6736998A/en
Priority to CA002283490A priority patent/CA2283490A1/fr
Publication of WO1998040493A1 publication Critical patent/WO1998040493A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Definitions

  • This PCR product was cloned into the Hinc II site of plasmid vector pIC19R (Marsh et al. (1984) Gene 32 pp 481-485) to yield pPBSGAG.
  • FIV sequence from pPBSGAG was then released as a Sal I fragment and cloned into the Sal I site of pIC20H (Marsh et al. supra) to give pPBSSal.
  • the CMV IE promoter was cloned infront of these FIV sequences as a Bgl II-Kpn I fragment from expression vector pcDNA3 (Invitrogen) , yielding pCMVPBS.
  • Sst I fragment from this clone including the IE promoter and FIV sequences from the primer binding site to the proviral Sst I site, was then cloned into the Sst I site in ⁇ RT-Sal/Sst.
  • the resulting DNA sequence from within the CMV IE promoter to a point downstream of the FIV proviral Sst I site was confirmed by direct sequencing.
  • A485 4 A495 6 mean 2.6 1 4.8

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne des formulations de vaccins contre les maladies liées au VIF (virus de l'immunodéficience féline), comportant un polynucléotide PVIF (provirus de l'immunodéficience féline) renfermant un gène pol dysfonctionnel, des fragments du polynucléotide PVIF et leurs utilisations dans la prophylaxie et/ou le traitement de maladies liées au VIF.
PCT/GB1998/000715 1997-03-11 1998-03-10 Vaccin anti-vif WO1998040493A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP53935198A JP2002501369A (ja) 1997-03-11 1998-03-10 Ｆｉｖワクチン
EP98912585A EP1007687A1 (fr) 1997-03-11 1998-03-10 Vaccin anti-vif
AU67369/98A AU6736998A (en) 1997-03-11 1998-03-10 Fiv vaccine
CA002283490A CA2283490A1 (fr) 1997-03-11 1998-03-10 Vaccin anti-vif

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9704977.9 1997-03-11
GBGB9704977.9A GB9704977D0 (en) 1997-03-11 1997-03-11 FIV vaccine

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09380990 A-371-Of-International 1999-11-08
US10/205,534 Continuation US20030118601A1 (en) 1997-03-11 2002-07-25 FIV vaccine

Publications (1)

Publication Number Publication Date
WO1998040493A1 true WO1998040493A1 (fr) 1998-09-17

Family

ID=10809020

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1998/000715 WO1998040493A1 (fr) 1997-03-11 1998-03-10 Vaccin anti-vif

Country Status (6)

Country Link
EP (1) EP1007687A1 (fr)
JP (1) JP2002501369A (fr)
AU (1) AU6736998A (fr)
CA (1) CA2283490A1 (fr)
GB (1) GB9704977D0 (fr)
WO (1) WO1998040493A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0997529A2 (fr) * 1998-08-24 2000-05-03 Pfizer Products Inc. Souche FIV-141 du virus de l'immunodéficience féline et ses utilisations
EP1037669A1 (fr) * 1997-12-12 2000-09-27 Luigi Naldini Emploi therapeutique de vecteurs lentiviraux
US6667295B1 (en) 1999-06-14 2003-12-23 Pfizer, Inc. DNA vaccine against feline immunodeficiency virus
US6713286B2 (en) 1998-08-24 2004-03-30 Pfizer Inc. Compositions and methods for protecting animals from lentivirus-associated disease such as feline immunodeficiency virus
US20130254112A1 (en) * 2010-04-09 2013-09-26 Ayman Hammad System and Method Including Chip-Based Device Processing For Transaction

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996003435A2 (fr) * 1994-07-21 1996-02-08 Q-One Biotech Limited Gamma-interferon d'origine feline
WO1997032983A1 (fr) * 1996-03-05 1997-09-12 The Regents Of The University Of California Virus de l'immunodeficience feline vivants recombines et vaccins d'adn proviraux

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996003435A2 (fr) * 1994-07-21 1996-02-08 Q-One Biotech Limited Gamma-interferon d'origine feline
WO1997032983A1 (fr) * 1996-03-05 1997-09-12 The Regents Of The University Of California Virus de l'immunodeficience feline vivants recombines et vaccins d'adn proviraux

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LU S ET AL.: "Simian Immunodeficiency Virus DNA vaccine trial in macaques", JOURNAL OF VIROLOGY, vol. 70, no. 6, June 1996 (1996-06-01), AMERICAN SOCIETY FOR MICROBIOLOGY US, pages 3978 - 3991, XP002071527 *
LUTZ H ET AL.: "Vaccination of cats with recombinant envelope glycoprotein of Feline Immunodeficiency Virus: Decreased virus load after challenge infection", AIDS RESEARCH AND HUMAN RETROVIRUSES., vol. 12, no. 5, 20 March 1996 (1996-03-20), LIEBERT US, pages 431 - 433, XP002071528 *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1037669A1 (fr) * 1997-12-12 2000-09-27 Luigi Naldini Emploi therapeutique de vecteurs lentiviraux
EP1037669A4 (fr) * 1997-12-12 2003-04-02 Cell Genesys Inc Emploi therapeutique de vecteurs lentiviraux
EP0997529A2 (fr) * 1998-08-24 2000-05-03 Pfizer Products Inc. Souche FIV-141 du virus de l'immunodéficience féline et ses utilisations
EP0997529A3 (fr) * 1998-08-24 2002-05-22 Pfizer Products Inc. Souche FIV-141 du virus de l'immunodéficience féline et ses utilisations
US6713286B2 (en) 1998-08-24 2004-03-30 Pfizer Inc. Compositions and methods for protecting animals from lentivirus-associated disease such as feline immunodeficiency virus
US6764676B1 (en) 1998-08-24 2004-07-20 Pfizer Inc. Compositions and methods for protecting animals from lentivirus-associated disease such as feline immunodeficiency virus
US6667295B1 (en) 1999-06-14 2003-12-23 Pfizer, Inc. DNA vaccine against feline immunodeficiency virus
US20130254112A1 (en) * 2010-04-09 2013-09-26 Ayman Hammad System and Method Including Chip-Based Device Processing For Transaction
US8977570B2 (en) * 2010-04-09 2015-03-10 Visa International Service Association System and method including chip-based device processing for transaction

Also Published As

Publication number Publication date
CA2283490A1 (fr) 1998-09-17
AU6736998A (en) 1998-09-29
EP1007687A1 (fr) 2000-06-14
GB9704977D0 (en) 1997-04-30
JP2002501369A (ja) 2002-01-15

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