WO1998039043A1 - Appareil permettant la distribution dosee de substances - Google Patents

Appareil permettant la distribution dosee de substances Download PDF

Info

Publication number
WO1998039043A1
WO1998039043A1 PCT/EP1998/001167 EP9801167W WO9839043A1 WO 1998039043 A1 WO1998039043 A1 WO 1998039043A1 EP 9801167 W EP9801167 W EP 9801167W WO 9839043 A1 WO9839043 A1 WO 9839043A1
Authority
WO
WIPO (PCT)
Prior art keywords
cartridge
mouthpiece
piston
cylinder
particular according
Prior art date
Application number
PCT/EP1998/001167
Other languages
German (de)
English (en)
Inventor
Alfred Von Schuckmann
Original Assignee
Alfred Von Schuckmann
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfred Von Schuckmann filed Critical Alfred Von Schuckmann
Priority to AU68257/98A priority Critical patent/AU6825798A/en
Publication of WO1998039043A1 publication Critical patent/WO1998039043A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/0035—Piercing means
    • A61M15/0036—Piercing means hollow piercing means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/06—Gas or vapour producing the flow, e.g. from a compressible bulb or air pump
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/06—Gas or vapour producing the flow, e.g. from a compressible bulb or air pump
    • B05B11/062—Gas or vapour producing the flow, e.g. from a compressible bulb or air pump designed for spraying particulate material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
    • B05B11/109—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle the dispensing stroke being affected by the stored energy of a spring
    • B05B11/1091—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle the dispensing stroke being affected by the stored energy of a spring being first hold in a loaded state by locking means or the like, then released
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/08—Inhaling devices inserted into the nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/07—General characteristics of the apparatus having air pumping means
    • A61M2205/071—General characteristics of the apparatus having air pumping means hand operated
    • A61M2205/073—Syringe, piston type

Definitions

  • 00001 Device for the metered dispensing of substances 00002 00003 The invention relates to a device for the metered 00004 dispensing of substances, in particular medication, from 00005 a cartridge which can be inserted into the device with the participation of an air 00007 stream formed by a moving piston which flows through the opening of a mouthpiece encompassing the cartridge emerges, which mouthpiece lies coaxially 00009 to the direction of movement of the piston loaded by a triggerable 00010 energy storage spring.
  • 00011 00012 This device is the subject of the unpublished 00013 th German patent application 19533 979.7. There the airflow is released at the compression peak of an air cushion generated by 00015 the piston. The 00016 tensioning of the energy storage spring is done via wings.
  • 00017 the latter sit on the end of the 00018 shaft of the piston facing away from the mouthpiece. They are accessible without actuation and run in laterally open longitudinal shafts of the 00020 housing of the device.
  • 00021 00022 The object of the invention is to develop a generic device 00023 actuation and function advantageous. This task is first and essentially at 00026 a device for the metered delivery of substances with 00027 the features of claim 1 solved, 00028 being based on the fact that the mouthpiece is the handle for 00029 charging the energy storage spring. A component that is part of the basic equipment without 00030 is used. The 00031 remaining part of the device forms a larger grip zone for 00032 the counter support when charging. The device can also be made 00033 leaner. It moves in size 00034 almost the size of a writing instrument (fountain pen00035 ter). Functionally, the corresponding edition 00036 fertilizer so that the cylinder assigned to the piston
  • Neighboring piercing pin has to open the
  • 00060 is the cartridge until the time of application
  • 00070 hung also of the sinuses can be an oral application 00071 with one and the same device, where
  • 00081 acts as the easiest way to reach the gutter. Further
  • a favorable feature of the invention is that
  • 00091 position can be brought to the cartridge-shaped housing.
  • 00103 is a partial length of the power spring. The other
  • a white 00106 tero function falls to the guide tube 00107 that the upper end of the central guide tube 00108 forms an extension stop.
  • the corresponding grip 00114 of a counterhold is optimized in that the section of the cylinder which is in a 00115 free-standing position has 00007 grooves if it preferably has a transverse jacket wall.
  • the cartridge-shaped device can be clipped onto a storage housing which holds the 00119 cartridges.
  • the latter can be closed with a sliding lid and can hold a quantity covering the daily dosage, be it 00122 cartridges in a powder-containing or 00123 liquid-containing form.
  • the dispensing spout which is advantageous for the oral appli00124 cation, can be accommodated in the storage case 00125 by finally proceeding in this regard in such a way that a portion of the interior of the pre-00127 council housing is separated to form a compartment for the dispensing receptacle. This is done 00129 simply by forming a partition.
  • FIG. 1 the device according to the invention in perspective 00136 representation, releasably assigns a storage case 00137; 00138 00139
  • FIG. 2 the device in vertical section, enlarged compared to FIG. 1 00140, fitted with cartridges and with the energy storage spring in 00141 charge; 00142 00143
  • Figure 3 shows the section as Figure 2, but after triggering 00144 the mechanism.
  • 00145 00146 Figure 4 shows the device in side view.
  • 00147 00148 Figure 5 shows the top view of the device; 00149 00150 Fig.
  • FIG. 12 is a plan view of a dispensing spout that can be assigned to the head or 00168 mouthpiece of the device; 00170 00171 Fig. 13 the same in side view; 00172 14 shows the dispensing spout in a side view rotated by 90 °; 00175 00176 FIG. 15 shows the device with 00177 output nozzle assigned in terms of plug technology in vertical section and 00178 00179 FIG. 16 shows a representation corresponding to FIG. 15 offset by 00180 90 °, only the output nozzle 00181 being illustrated in section. 00182 00183 The 00184 device shown in its entirety, designated G, is used for the airborne delivery of cartridges around 00185 closed substances 1.
  • the discharge of the metered 00186 content by means of device G is powerful and targeted.
  • the airflow is not biased; rather 00188 the air held ready is practically expelled as it were.
  • 00190 00191 The cartridge containing the corresponding substance 1, liquid or pulvri00192 ger type, bears the reference number 00193 K. 00194 00195
  • the device G is designed with a view to a simple cartridge change and ease of use.
  • 00197 It is primarily used for nasal application, but can also be used for oral application 00199 through an additional component.
  • 00200 00201 The corresponding medicament is accommodated in the elongated cartridge K.
  • the accommodation space 00203 2 of the basically tubular cartridge 00204 K is film-closed at both ends.
  • 00205 is a penetrable floor surface 3 and a ceiling 00206 surface 4.
  • the ceiling surface 4 faces a mouthpiece 5 00207 of the device G; the bottom surface 3, however 00208 points in the direction of a piston / cylinder unit E, the 00209 heart of the device G.
  • 00210 00211
  • One of the two surfaces can also be molded onto the cartridge K 00212.
  • the outer wall of the cartridge K has a grooving 6 00215. This runs transversely to the longitudinal central axis xx of the device G, which is basically rotationally symmetrical in 00216. In 00217 of this axis, the cartridge K is also inserted 00218. A rich crease 6 is made.
  • the 00219 increases the grip and reduces the contamination area.
  • the ring grooves forming the groove 6 have 00221 an axially greater length than the length or width of the ring rip 00223 pen measured in this direction 00222.
  • the end ring ribs are significantly thicker.
  • 00224 Your end edges have a chamfer.
  • 00225 00226 The air flow 00227 causing the airborne application is generated in the back of the cartridge K.
  • the cylinder space in this regard is designated by 7. Its cylinder 8 00229 accommodates a piston 9 00230 that can be moved with limited movement.
  • a force-storing spring 10 which drives the piston 9 00231 after releasing it in the direction of the 00232 mouthpiece 5.
  • It 00233 is a helical compression spring.
  • Their 00234 a terminal turn is supported on a floor 11 00235 of the device G.
  • the other terminal spring turn 00236 finds its abutment in the back 12 of the piston 9.
  • Besag00237 ter back 12 forms a receiving recess centering the energy storage spring 10 there 00238.
  • the end face of the 00239 piston 9 is flat except for an edge lip.
  • a piercing mandrel 19 projects freestanding therein.
  • 00254 can be a 00255 cross-profiled mandrel. It tips out on the mouthpiece side.
  • 00256 00257 The free end of the piercing mandrel 19 protrudes into a 00258 receiving chamber 20.
  • the lower end of the 00259 cartridge K is inserted frictionally into this, 00260 inevitably leading to mandrel penetration, ie opening 00261 of the bottom surface 3 of the cartridge K.
  • 00262 00263 The cartridge K enters a clamp-on seat that can be lifted again with emphasis on the will.
  • the passage 00265 is given away to the accommodation space 2, since the 00266 inner wall of the accommodation space 2 essentially corresponds to the inner wall of the opening 18 of the 00268 receiving chamber 20 is aligned and the piercing pin 19 00269 is clearly spaced from the wall.
  • 00272 00273 The receiving chamber 20 is formed by an intermediate part 21 which is firmly attached to the ceiling 00274 17. It is designed 00275 pot-shaped. Its rim holds an O-ring 00276 22 in position. Its material is elastic.
  • the O-ring 22 is located in a radial groove, 00279 the piston side of which is limited due to a peripheral shoulder 23 of the cylinder 8.
  • 00281 00282 While the receiving chamber 20 is formed by a ring 00284 projecting in the direction of 00283 of the mouthpiece 5 of the intermediate part 21, a ring wall in the opposite direction 00285, that is to say on the cylinder chamber side, describes the central opening 18.
  • 00287 00288 beneath this the 00289 ring wall forming the central opening 18 extends a rotationally symmetrically shaped deflection pocket 24. The latter functions as a catch ring 00291 ne for powdery substance 1 emerging from the perforation of the bottom surface 3.
  • the deflection pocket 24 is basically 00293 plate-shaped.
  • the rim of the plate protrudes over 00294 and the ring wall of opening 00295 facing 18 on the cylinder chamber side.
  • the edge and wall are radially gap-sealed.
  • 00297 00298 Said deflection pocket 24 is in flow connection 00299 with peripheral flow channels 25.
  • the latter 00300 can be determined by radial ribs which form a material bridge between the central area of the ceiling 17 00302 and the periphery of the cylinder 8.
  • a total of 00303 results in a rotationally symmetrical S-flow joint. Powder particles that have got into the deflection pocket 24 are completely carried away in the discharge direction.
  • the underside of the ceiling 17 is flat.
  • 00307 00308 To complete the receiving chamber 20, the inner 00309 space of the mouthpiece 5 is used. The latter forms 00310 the lengthwise predominant section of the receiving chamber 00311 of the cartridge K. This section bears the reference 00312 character 20 '. It lowers when the mouth is assigned 00313 piece 5 over the free-standing remaining section of the Kartu00314 Sche K. It is thus interposed with a limit stop.
  • 00315 In the final position of this assignment, according to the basic version 00316 of the device G, FIGS. 1 to 7, and in a certain sense 00317 FIG. 15, the foil-sealed ceiling area 4 00318 is also dome-penetrated.
  • the mouthpiece 5 in the area 00319 of an opening 27 upstream of a nozzle 26 has the same 00320 if a piercing mandrel 28. It can also be cross-shaped 00321 and merges into a 00322 point on the cartridge side.
  • the board position of the pointed end 00323 of this piercing mandrel 28 is set up in such a way that with 00324 the proper inclusion of the cartridge K, defined by end support shoulders of the device G, 00326, the opening is also ensured there.
  • the piercing mandrel 28 is surrounded by flow channels 29.
  • the part that forms the nozzle 26 is manufactured separately 00330 and can accordingly be adapted to different editions 00331 shapes.
  • 00332 00333 The basically cap-shaped mouthpiece 5 has 00334 an annular seal 30. The latter circumscribes 00335 the lower entrance of section 20 'and is supported there 00336 on an inner shoulder 31 of mouthpiece 5.
  • the 00337 sealing counter surface forms the annular top 00338 of the flat bottom plate of the pot-shaped intermediate part 00339 21.
  • 00340 00341 The cap-shaped mouthpiece 5 can be set 00342 operationally on the cartridge-shaped housing 15. For this purpose 00343 a bayonet locking device 32 is used.
  • the typical 00344 angular slot of the bayonet locking device 32 is realized in 00345 in the essentially cylindrical cap wall of the 00346 mouthpiece 5 and is designated by 33.
  • a 00347 associated locking pin 34 sits on the outer wall of the 00348 housing 15.
  • the bayonet locking device 32 is provided in pairs 00349. They are in the diametrical orien00350.
  • the mouthpiece 5 is the handle for charging the 00353 energy storage spring 10.
  • 00354 00355 For this purpose, the cylinder 8 assigned to the piston 9 00356 is shifted relative to the piston 9 into a 00357 readiness for clamping position by means of the mouthpiece 5 (cf. FIG. 7).
  • the 00372 mouthpiece 5 has an annular groove 35 in its cap-shaped interior at a suitable location for 00373.
  • the corresponding 00374 latching stop is such that the friction forces occurring when pulling out the Zylin00375 ders 8 are finally overcome; only in an extended end position can 00377 separate the mouthpiece 5 from the pulled-out part 00378 8.
  • 00379 00380 With the help of the mouthpiece 5, the unit Zylin00381 of the 8 / piston 9 is now shifted into the energy storage spring charging position 00382, which is achieved by inserting the cylinder 8 00383 happens in the housing 15.
  • the cylinder 8 enters 00384 into a locked position y of its cover 17 00385 to the piston 9, in which cylinder 8 and piston 9 are inserted under 00386 charging the energy storage spring 10 into a releasable 00387 locking position in the cartridge-shaped housing 15 of the 00388 device G.
  • 00389 00390 The backward displacement 00391 of the piston 9 going in the direction of the bottom 11 is active via the free end face 36 of the cylinder 8 lying in this direction 00392.
  • the latter 00393 interacts with a steep flank 37 on the piston skirt 38. Said steep flank is, like the end face 36 00395, perpendicular to the longitudinal central axis xx of the device G.
  • the 00465 longitudinal groove 53 is continuous and cuts out 00466 on the front side of the housing, which area is closed by the 00467 plug-like base 11.
  • 00468 00469 The other parts of the telescopic 00470 interior are also secured against rotation.
  • 00471 00472 The variant according to FIGS. 8 to 11 is in principle 00473 of the same structure. The reference numbers are used analogously to 00474, sometimes without repeated text.
  • 00475 The cartridge K is further developed there.
  • Piston side 00476 closes here also by a pierceable surface 00477 surface 3.
  • the ceiling surface 4, however, is so trained and arranged that it is not exposed to a 00479 piercing mandrel on the mouthpiece side.
  • a head surface 4 '00481 sen.
  • the latter extends over a chimney-like extension 54.
  • 00482 This chimney-shaped or pipe socket-shaped extension 54 projects 00483 through an opening 55 in the mouthpiece 5.
  • the 00484 comprehensive deposition is the same and is again done over the shoulders 00485.
  • the head surface 4 ' which is designed in the form of a film or 00486 or the like, is set in a 00487 which laterally projects the cross section of the extension 00488 demolition flag 56 continued. The latter tapers towards 00489 of its free extension.
  • FIG. 10 shows predetermined breaking lines 57 in the 00510 head surface 4 'which closes the cartridge K. There is a crisscross arrangement of 51111. The remaining Abriß00512 flag 56 allows an optional handling.
  • FIG. 11 shows a head surface 4 ′ which is torn open by the flow pressure, holding said predetermined breaking lines 57 along 00516.
  • 00517 00518 The highlighted, grippy shape of the cartridge K 00519 via a groove 6 can also be used in relation to the cylinder 00521 of FIG.
  • 00522 has therefore proceeded in such a way that the is in a free-standing position 00523 kicking section of the cylinder 8 also sits a vor00524 preferably transverse transverse wall groove 58 be00525.
  • Another type of roughening is also conceivable 00526.
  • 00527 00528 As can be seen in FIG. 1, the device G described in detail 00529 can be clipped onto a cartridge K00530 of the storage housing 59. For this purpose, this has a docking cap 60 on 00531 on a narrow longitudinal side. In 00532 this is the mouth-side area tapering to the size of the nostril.
  • the latter has a 00536 through opening 62.
  • the G 00537 can be conveniently and securely angled in and unlocked again.
  • the 00538 axial position securing results from the use of the 00539 collar level 63 and the full insert of the mouth 00540 piece 5 in the funnel space of the docking cap 60.
  • 00541 00542 The length of the storage housing 59 is adjusted to a dimension that the device G takes in its basic position 00544. Overall, there is slightly more than one cigarette 00545 box size.
  • 00546 00547 Regarding the supply housing 59 remains to be noted that this is accessible via a groove-guided sliding cover 00549 64.
  • the latter expediently consists of 00550 transparent or translucent material.
  • 00551 an interior division is made in such a way that 00552 a part of the interior of the storage housing 59 is separated to 00553 to form a partitioned receiving chamber 65 for a 00554 dispensing spout 66.
  • Said dispensing spout 66 00555 is shown and used in 00556 in FIGS. 12 to 16.
  • the dispensing spout 66 can be put over the mouthpiece 5 as a 00557 plug-in part.
  • the receiving chamber 00559 mer 65 is such that it is primarily free when the sliding cover 64 is opened.
  • 00561 00562 By placing such an outlet spout 66, the 00563 device G can be switched over to use enabling oral application 00564 in the blink of an eye.
  • the edition 00565 spout 66 is not only bite-sized in this regard, i.e. not pointed as shaped for nasal application 00567, but realized as an oval 00568 pipe socket at least on the end.
  • 00569 technical flow considerations are taken into account in such a way that the 00570 outlet nozzle 66 with bypass-like openings 67 is provided with verse00571.
  • the user can use this to draw in supplementary air using 00572 suction.
  • the substance 1, which is finely distributed through the nozzle 26 in 00574 is transported to the 00575 destination bronchi etc.
  • 00576 00577 Said openings 67 are provided in pairs. It is located at the base of the lip or base of the 00579 output nozzle 66.
  • 00580 00581 All the features disclosed are essential to the invention.
  • the 00583 disclosure content of the associated / attached priority documents (copy of the prior application) is hereby fully incorporated, also for the purpose of including features of these 00586 documents in claims of the present application with 00587.

Abstract

Appareil (G) permettant la distribution dosée de substances (1), en particulier de médicaments, depuis une cartouche (K) pouvant être introduite dans ledit appareil (G), sous l'action d'un flux d'air qui est produit par le mouvement d'un piston (9) et sort par l'ouverture (27) d'un embout buccal (5) entourant la cartouche (K). Ledit embout est coaxial par rapport au sens de mouvement du piston (9) qui est contraint par un ressort (10) à accumulation d'énergie pouvant être déclenché. L'appareil selon la présente invention se caractérise par une grande facilité d'actionnement et de fonctionnement du fait que l'embout (5) constitue le dispositif de commande de charge du ressort (10) à accumulation d'énergie.
PCT/EP1998/001167 1997-03-03 1998-03-03 Appareil permettant la distribution dosee de substances WO1998039043A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU68257/98A AU6825798A (en) 1997-03-03 1998-03-03 Metered dispensing device for substances

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19708406A DE19708406A1 (de) 1997-03-03 1997-03-03 Gerät zur dosierten Ausgabe von Substanzen
DE19708406.0 1997-03-03

Publications (1)

Publication Number Publication Date
WO1998039043A1 true WO1998039043A1 (fr) 1998-09-11

Family

ID=7821970

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/001167 WO1998039043A1 (fr) 1997-03-03 1998-03-03 Appareil permettant la distribution dosee de substances

Country Status (3)

Country Link
AU (1) AU6825798A (fr)
DE (1) DE19708406A1 (fr)
WO (1) WO1998039043A1 (fr)

Cited By (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007141203A1 (fr) * 2006-06-02 2007-12-13 Boehringer Ingelheim International Gmbh Pulvérisateur
EP1923087A3 (fr) * 1999-07-23 2009-03-25 MannKind Corporation Capsules à dose d'unité et inhalateur de poudre sèche
US8912193B2 (en) 2008-06-13 2014-12-16 Mannkind Corporation Dry powder inhaler and system for drug delivery
US9220687B2 (en) 2008-12-29 2015-12-29 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
US9233159B2 (en) 2011-10-24 2016-01-12 Mannkind Corporation Methods and compositions for treating pain
US9241903B2 (en) 2006-02-22 2016-01-26 Mannkind Corporation Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
US9283193B2 (en) 2005-09-14 2016-03-15 Mannkind Corporation Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
US9346766B2 (en) 2004-08-20 2016-05-24 Mannkind Corporation Catalysis of diketopiperazine synthesis
US9358352B2 (en) 2008-06-13 2016-06-07 Mannkind Corporation Dry powder drug delivery system and methods
US9364619B2 (en) 2008-06-20 2016-06-14 Mannkind Corporation Interactive apparatus and method for real-time profiling of inhalation efforts
US9364436B2 (en) 2011-06-17 2016-06-14 Mannkind Corporation High capacity diketopiperazine microparticles and methods
US9393372B2 (en) 2008-06-13 2016-07-19 Mannkind Corporation Dry powder drug delivery system
US9545487B2 (en) 2012-04-13 2017-01-17 Boehringer Ingelheim International Gmbh Dispenser with encoding means
US9630930B2 (en) 2009-06-12 2017-04-25 Mannkind Corporation Diketopiperazine microparticles with defined specific surface areas
US9675674B2 (en) 2004-08-23 2017-06-13 Mannkind Corporation Diketopiperazine salts for drug delivery and related methods
US9682202B2 (en) 2009-05-18 2017-06-20 Boehringer Ingelheim International Gmbh Adapter, inhalation device, and atomizer
US9700690B2 (en) 2002-03-20 2017-07-11 Mannkind Corporation Inhalation apparatus
US9706944B2 (en) 2009-11-03 2017-07-18 Mannkind Corporation Apparatus and method for simulating inhalation efforts
US9724482B2 (en) 2009-11-25 2017-08-08 Boehringer Ingelheim International Gmbh Nebulizer
US9744313B2 (en) 2013-08-09 2017-08-29 Boehringer Ingelheim International Gmbh Nebulizer
US9757750B2 (en) 2011-04-01 2017-09-12 Boehringer Ingelheim International Gmbh Medicinal device with container
US9802012B2 (en) 2012-07-12 2017-10-31 Mannkind Corporation Dry powder drug delivery system and methods
US9801925B2 (en) 1999-06-29 2017-10-31 Mannkind Corporation Potentiation of glucose elimination
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
US9925144B2 (en) 2013-07-18 2018-03-27 Mannkind Corporation Heat-stable dry powder pharmaceutical compositions and methods
US9943571B2 (en) 2008-08-11 2018-04-17 Mannkind Corporation Use of ultrarapid acting insulin
US9943654B2 (en) 2010-06-24 2018-04-17 Boehringer Ingelheim International Gmbh Nebulizer
US9983108B2 (en) 2009-03-11 2018-05-29 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
US10004857B2 (en) 2013-08-09 2018-06-26 Boehringer Ingelheim International Gmbh Nebulizer
US10011906B2 (en) 2009-03-31 2018-07-03 Beohringer Ingelheim International Gmbh Method for coating a surface of a component
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
US10099022B2 (en) 2014-05-07 2018-10-16 Boehringer Ingelheim International Gmbh Nebulizer
US10124129B2 (en) 2008-01-02 2018-11-13 Boehringer Ingelheim International Gmbh Dispensing device, storage device and method for dispensing a formulation
US10124125B2 (en) 2009-11-25 2018-11-13 Boehringer Ingelheim International Gmbh Nebulizer
US10159644B2 (en) 2012-10-26 2018-12-25 Mannkind Corporation Inhalable vaccine compositions and methods
US10195374B2 (en) 2014-05-07 2019-02-05 Boehringer Ingelheim International Gmbh Container, nebulizer and use
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
US10421729B2 (en) 2013-03-15 2019-09-24 Mannkind Corporation Microcrystalline diketopiperazine compositions and methods
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
US10625034B2 (en) 2011-04-01 2020-04-21 Mannkind Corporation Blister package for pharmaceutical cartridges
US10722666B2 (en) 2014-05-07 2020-07-28 Boehringer Ingelheim International Gmbh Nebulizer with axially movable and lockable container and indicator
US11446127B2 (en) 2013-08-05 2022-09-20 Mannkind Corporation Insufflation apparatus and methods

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA200306564B (en) * 2001-02-26 2004-10-15 Optinose As Nasal devices.
DE10164452A1 (de) * 2001-12-21 2003-07-03 Pfeiffer Erich Gmbh & Co Kg Spender für Medien
US11957831B2 (en) 2018-09-27 2024-04-16 Shl Medical Ag Activation mechanism for an aerosol dispenser
CN115461103A (zh) * 2020-03-05 2022-12-09 赛诺丝有限公司 用于将物质输送到体腔的装置和方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992006727A1 (fr) * 1990-10-12 1992-04-30 Novo Nordisk A/S Distributeur de poudres jetable
WO1997010017A1 (fr) * 1995-09-14 1997-03-20 Alfred Von Schuckmann Appareil pour la distribution au moyen d'air de doses de substances

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992006727A1 (fr) * 1990-10-12 1992-04-30 Novo Nordisk A/S Distributeur de poudres jetable
WO1997010017A1 (fr) * 1995-09-14 1997-03-20 Alfred Von Schuckmann Appareil pour la distribution au moyen d'air de doses de substances

Cited By (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9801925B2 (en) 1999-06-29 2017-10-31 Mannkind Corporation Potentiation of glucose elimination
EP1923087A3 (fr) * 1999-07-23 2009-03-25 MannKind Corporation Capsules à dose d'unité et inhalateur de poudre sèche
US9700690B2 (en) 2002-03-20 2017-07-11 Mannkind Corporation Inhalation apparatus
US9346766B2 (en) 2004-08-20 2016-05-24 Mannkind Corporation Catalysis of diketopiperazine synthesis
US9796688B2 (en) 2004-08-20 2017-10-24 Mannkind Corporation Catalysis of diketopiperazine synthesis
US10130685B2 (en) 2004-08-23 2018-11-20 Mannkind Corporation Diketopiperazine salts for drug delivery and related methods
US9675674B2 (en) 2004-08-23 2017-06-13 Mannkind Corporation Diketopiperazine salts for drug delivery and related methods
US9717689B2 (en) 2005-09-14 2017-08-01 Mannkind Corporation Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
US9283193B2 (en) 2005-09-14 2016-03-15 Mannkind Corporation Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
US10143655B2 (en) 2005-09-14 2018-12-04 Mannkind Corporation Method of drug formulation
US9446001B2 (en) 2005-09-14 2016-09-20 Mannkind Corporation Increasing drug affinity for crystalline microparticle surfaces
US10130581B2 (en) 2006-02-22 2018-11-20 Mannkind Corporation Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
US9241903B2 (en) 2006-02-22 2016-01-26 Mannkind Corporation Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
WO2007141203A1 (fr) * 2006-06-02 2007-12-13 Boehringer Ingelheim International Gmbh Pulvérisateur
US10124129B2 (en) 2008-01-02 2018-11-13 Boehringer Ingelheim International Gmbh Dispensing device, storage device and method for dispensing a formulation
US9446133B2 (en) 2008-06-13 2016-09-20 Mannkind Corporation Dry powder inhaler and system for drug delivery
US9358352B2 (en) 2008-06-13 2016-06-07 Mannkind Corporation Dry powder drug delivery system and methods
US10201672B2 (en) 2008-06-13 2019-02-12 Mannkind Corporation Dry powder inhaler and system for drug delivery
US9393372B2 (en) 2008-06-13 2016-07-19 Mannkind Corporation Dry powder drug delivery system
US10342938B2 (en) 2008-06-13 2019-07-09 Mannkind Corporation Dry powder drug delivery system
US8912193B2 (en) 2008-06-13 2014-12-16 Mannkind Corporation Dry powder inhaler and system for drug delivery
US9662461B2 (en) 2008-06-13 2017-05-30 Mannkind Corporation Dry powder drug delivery system and methods
US9511198B2 (en) 2008-06-13 2016-12-06 Mannkind Corporation Dry powder inhaler and system for drug delivery
US9339615B2 (en) 2008-06-13 2016-05-17 Mannkind Corporation Dry powder inhaler and system for drug delivery
US9192675B2 (en) 2008-06-13 2015-11-24 Mankind Corporation Dry powder inhaler and system for drug delivery
US10751488B2 (en) 2008-06-13 2020-08-25 Mannkind Corporation Dry powder inhaler and system for drug delivery
US10675421B2 (en) 2008-06-20 2020-06-09 Mannkind Corporation Interactive apparatus and method for real-time profiling of inhalation efforts
US9364619B2 (en) 2008-06-20 2016-06-14 Mannkind Corporation Interactive apparatus and method for real-time profiling of inhalation efforts
US9943571B2 (en) 2008-08-11 2018-04-17 Mannkind Corporation Use of ultrarapid acting insulin
US10172850B2 (en) 2008-12-29 2019-01-08 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
US9220687B2 (en) 2008-12-29 2015-12-29 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
US9655850B2 (en) 2008-12-29 2017-05-23 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
US9983108B2 (en) 2009-03-11 2018-05-29 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
US10011906B2 (en) 2009-03-31 2018-07-03 Beohringer Ingelheim International Gmbh Method for coating a surface of a component
US9682202B2 (en) 2009-05-18 2017-06-20 Boehringer Ingelheim International Gmbh Adapter, inhalation device, and atomizer
US9630930B2 (en) 2009-06-12 2017-04-25 Mannkind Corporation Diketopiperazine microparticles with defined specific surface areas
US9706944B2 (en) 2009-11-03 2017-07-18 Mannkind Corporation Apparatus and method for simulating inhalation efforts
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
US9724482B2 (en) 2009-11-25 2017-08-08 Boehringer Ingelheim International Gmbh Nebulizer
US10124125B2 (en) 2009-11-25 2018-11-13 Boehringer Ingelheim International Gmbh Nebulizer
US9943654B2 (en) 2010-06-24 2018-04-17 Boehringer Ingelheim International Gmbh Nebulizer
US9757750B2 (en) 2011-04-01 2017-09-12 Boehringer Ingelheim International Gmbh Medicinal device with container
US10625034B2 (en) 2011-04-01 2020-04-21 Mannkind Corporation Blister package for pharmaceutical cartridges
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
US9364436B2 (en) 2011-06-17 2016-06-14 Mannkind Corporation High capacity diketopiperazine microparticles and methods
US10130709B2 (en) 2011-06-17 2018-11-20 Mannkind Corporation High capacity diketopiperazine microparticles and methods
US9233159B2 (en) 2011-10-24 2016-01-12 Mannkind Corporation Methods and compositions for treating pain
US9610351B2 (en) 2011-10-24 2017-04-04 Mannkind Corporation Methods and compositions for treating pain
US10258664B2 (en) 2011-10-24 2019-04-16 Mannkind Corporation Methods and compositions for treating pain
US10220163B2 (en) 2012-04-13 2019-03-05 Boehringer Ingelheim International Gmbh Nebuliser with coding means
US9545487B2 (en) 2012-04-13 2017-01-17 Boehringer Ingelheim International Gmbh Dispenser with encoding means
US9802012B2 (en) 2012-07-12 2017-10-31 Mannkind Corporation Dry powder drug delivery system and methods
US10159644B2 (en) 2012-10-26 2018-12-25 Mannkind Corporation Inhalable vaccine compositions and methods
US10421729B2 (en) 2013-03-15 2019-09-24 Mannkind Corporation Microcrystalline diketopiperazine compositions and methods
US9925144B2 (en) 2013-07-18 2018-03-27 Mannkind Corporation Heat-stable dry powder pharmaceutical compositions and methods
US11446127B2 (en) 2013-08-05 2022-09-20 Mannkind Corporation Insufflation apparatus and methods
US10004857B2 (en) 2013-08-09 2018-06-26 Boehringer Ingelheim International Gmbh Nebulizer
US9744313B2 (en) 2013-08-09 2017-08-29 Boehringer Ingelheim International Gmbh Nebulizer
US10894134B2 (en) 2013-08-09 2021-01-19 Boehringer Ingelheim International Gmbh Nebulizer
US11642476B2 (en) 2013-08-09 2023-05-09 Boehringer Ingelheim International Gmbh Nebulizer
US10716905B2 (en) 2014-02-23 2020-07-21 Boehringer Lngelheim International Gmbh Container, nebulizer and use
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
US10099022B2 (en) 2014-05-07 2018-10-16 Boehringer Ingelheim International Gmbh Nebulizer
US10195374B2 (en) 2014-05-07 2019-02-05 Boehringer Ingelheim International Gmbh Container, nebulizer and use
US10722666B2 (en) 2014-05-07 2020-07-28 Boehringer Ingelheim International Gmbh Nebulizer with axially movable and lockable container and indicator
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler

Also Published As

Publication number Publication date
DE19708406A1 (de) 1998-09-10
AU6825798A (en) 1998-09-22

Similar Documents

Publication Publication Date Title
WO1998039043A1 (fr) Appareil permettant la distribution dosee de substances
EP1523365B1 (fr) Inhalateur à actionnement manuel pour substances pulvérulentes
EP1027165B1 (fr) Procede permettant de distribuer au moins deux produits differents et distributeur a cet effet
EP0957962B1 (fr) Distributeur de substances
EP0530625B1 (fr) Distributeur de fluides
DE2654018C2 (de) Aerosolinhalator
EP1536894B1 (fr) Appareil permettant d'expulser des liquides, cartouches adaptees et systeme compose de l'appareil permettant d'expulser les liquides et de la cartouche
EP0892681B1 (fr) Cartouche a deux chambres pour distribuer sans gaz propulseur des aerosols doses
EP1993643B1 (fr) Inhalateur pour substances pulvérulentes
DE1287260B (de) Spraygeraet
WO2009065707A1 (fr) Dispositif de dosage destiné à l'inhalation d'une substance pulvérulente
EP0373237A1 (fr) Dispositif d'inhalateur de poche
DE19622124A1 (de) Gerät zum Aufbringen von Flüssigkeiten
WO2007009872A1 (fr) Inhalateur pour substances pulverulentes, notamment substances medicinales
WO1995028857A1 (fr) Recipient rechargeable distribuant une matiere applicable, notamment une matiere adhesive
DE10047722A1 (de) Von Saugluftstrom des Benutzers aktivierbare Dosiervorrichtung
EP3793748A1 (fr) Applicateur
WO1995029723A1 (fr) Inhalateur
WO2009059894A1 (fr) Appareil manuel d'ihhalation de substances
EP2094583B1 (fr) Distributeur à commande manuelle pour masses pâteuses à fluides et leur récipient d'amarrage
WO2011154371A1 (fr) Distributeur pour substance pulvérulente contenue dans un emballage séparé
WO2017191125A2 (fr) Dispositif de délivrance d'une substance pouvant être évacuée par l'air
WO1995012428A1 (fr) Procede et dispositif permettant de produire un aerosol a partir d'une substance pulverulente
WO1991017098A1 (fr) Distributeur pour matieres pateuses
DE19750872A1 (de) Vorrichtung zum Inhalieren pulverförmiger Substanzen

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM GW HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

WA Withdrawal of international application
121 Ep: the epo has been informed by wipo that ep was designated in this application
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

NENP Non-entry into the national phase

Ref country code: CA