WO1998039043A1 - Metered dispensing device for substances - Google Patents

Metered dispensing device for substances Download PDF

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Publication number
WO1998039043A1
WO1998039043A1 PCT/EP1998/001167 EP9801167W WO9839043A1 WO 1998039043 A1 WO1998039043 A1 WO 1998039043A1 EP 9801167 W EP9801167 W EP 9801167W WO 9839043 A1 WO9839043 A1 WO 9839043A1
Authority
WO
WIPO (PCT)
Prior art keywords
characterized
mouthpiece
preceding
cartridge
piston
Prior art date
Application number
PCT/EP1998/001167
Other languages
German (de)
French (fr)
Inventor
Alfred Von Schuckmann
Original Assignee
Alfred Von Schuckmann
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE1997108406 priority Critical patent/DE19708406A1/en
Priority to DE19708406.0 priority
Application filed by Alfred Von Schuckmann filed Critical Alfred Von Schuckmann
Publication of WO1998039043A1 publication Critical patent/WO1998039043A1/en

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Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING LIQUIDS OR OTHER FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05BSPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00Single-unit, i.e. unitary, hand-held apparatus comprising a container and a discharge nozzle attached thereto, in which flow of liquid or other fluent material is produced by the muscular energy of the operator at the moment of use or by an equivalent manipulator independent from the apparatus
    • B05B11/30Single-unit, i.e. unitary, hand-held apparatus comprising a container and a discharge nozzle attached thereto, in which flow of liquid or other fluent material is produced by the muscular energy of the operator at the moment of use or by an equivalent manipulator independent from the apparatus the flow being effected by a pump
    • B05B11/309Single-unit, i.e. unitary, hand-held apparatus comprising a container and a discharge nozzle attached thereto, in which flow of liquid or other fluent material is produced by the muscular energy of the operator at the moment of use or by an equivalent manipulator independent from the apparatus the flow being effected by a pump the dispensing stroke being effected by the stored energy of a spring
    • B05B11/3091Single-unit, i.e. unitary, hand-held apparatus comprising a container and a discharge nozzle attached thereto, in which flow of liquid or other fluent material is produced by the muscular energy of the operator at the moment of use or by an equivalent manipulator independent from the apparatus the flow being effected by a pump the dispensing stroke being effected by the stored energy of a spring being first hold in a loaded state by locking means or the like, then released
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033Details of the piercing or cutting means
    • A61M15/0035Piercing means
    • A61M15/0036Piercing means hollow piercing means
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING LIQUIDS OR OTHER FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05BSPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00Single-unit, i.e. unitary, hand-held apparatus comprising a container and a discharge nozzle attached thereto, in which flow of liquid or other fluent material is produced by the muscular energy of the operator at the moment of use or by an equivalent manipulator independent from the apparatus
    • B05B11/06Single-unit, i.e. unitary, hand-held apparatus comprising a container and a discharge nozzle attached thereto, in which flow of liquid or other fluent material is produced by the muscular energy of the operator at the moment of use or by an equivalent manipulator independent from the apparatus the spray being effected by a gas or vapour flow from a source where the gas or vapour is not in contact with the liquid or other fluent material to be sprayed, e.g. from a compressible bulb, an air pump or an enclosure surrounding the container
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING LIQUIDS OR OTHER FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05BSPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00Single-unit, i.e. unitary, hand-held apparatus comprising a container and a discharge nozzle attached thereto, in which flow of liquid or other fluent material is produced by the muscular energy of the operator at the moment of use or by an equivalent manipulator independent from the apparatus
    • B05B11/06Single-unit, i.e. unitary, hand-held apparatus comprising a container and a discharge nozzle attached thereto, in which flow of liquid or other fluent material is produced by the muscular energy of the operator at the moment of use or by an equivalent manipulator independent from the apparatus the spray being effected by a gas or vapour flow from a source where the gas or vapour is not in contact with the liquid or other fluent material to be sprayed, e.g. from a compressible bulb, an air pump or an enclosure surrounding the container
    • B05B11/062Single-unit, i.e. unitary, hand-held apparatus comprising a container and a discharge nozzle attached thereto, in which flow of liquid or other fluent material is produced by the muscular energy of the operator at the moment of use or by an equivalent manipulator independent from the apparatus the spray being effected by a gas or vapour flow from a source where the gas or vapour is not in contact with the liquid or other fluent material to be sprayed, e.g. from a compressible bulb, an air pump or an enclosure surrounding the container designed for spraying particulate material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/08Inhaling devices inserted into the nose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00Special media to be introduced, removed or treated
    • A61M2202/06Solids
    • A61M2202/064Powder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/07General characteristics of the apparatus having air pumping means
    • A61M2205/071General characteristics of the apparatus having air pumping means hand operated
    • A61M2205/073Syringe, piston type

Abstract

The invention relates to a device (G) for metered dispensing of substances (1), especially medicaments, wherein said substances are dispensed from a cartridge (K) which can be introduced into the inventive device (G) under the effect of an air flow which is produced by a piston (9) movement and which exits via an opening (27) of the mouthpiece (5) encompassing the cartridge. Said mouthpiece is coaxial to the direction of the movement of a piston (9) which is subjected to a load from a releasable energy accumulator spring (10). The inventive device is easy to actuate and exhibits functional advantages by virtue of the fact that the mouthpiece (5) is used to load the energy accumulator spring (10).

Description

00001 device for the metered delivery of substances 00002 00003 The invention relates to a device for the metered output 00004 of substances, in particular drugs, from 00005 a cartridge inserted into the apparatus under Mitwir00006 effect of an air formed by a moving piston 00007 current flowing through the opening of the cartridge outlet send umfas00008 mouthpiece, which mouthpiece is located coaxially 00009 to the movement direction of the loaded by a releasable 00010 force accumulator spring piston. 00011 00012 This device is the subject of not vorveröffentlich00013 th German patent application 19 533 979.7. There, the air flow in the compression peak of an air cushion generated by 00,015 the piston is released 00,014th The 00,016 tensioning the power storage spring takes over wings. 00017 latter sitting at the side remote from the mouthpiece end of the shaft 00018 of the piston. They are free of activity zugäng00019 Lich and run in a laterally open longitudinal slots of the housing of the device 00020. 00021 00022 object of the invention is operating and functional advantageous to develop a generic device 00,023th 00024 00025 This object is achieved first and foremost the features of claim 1 substantially at 00026 a device for the metered delivery of substances with 00027, which is based on the fact 00028, that the mouthpiece is the handle for 00029 charging the energy storing spring. So a ohne00030 is used towards the basic equipment belonging component. The remaining part of the device 00031 is greater Anfaßzone 00032 for the counter-stop during charging. The device can be designed slimmer as well 00,033th It moves in size almost 00,034 in the dimensions of a writing instrument (Füllfederhal00035 ter). Functionally provides the corresponding Aufla- 00036 fertil like that associated with the piston cylinder

by means of the mouthpiece to the piston in a tensioning relatively 00037

00038 standby position and together with the piston in

00039 the power storage spring-charging position is displaced.

00040 Thus, there occurs no externally noticeable during use

00041 shifting to a component. By means of the mouthpiece

00042, the cylinder is brought forward and back zurückgescho-

00043 Ben. For the corresponding Zugmitnahme above all it is

00044 of advantage that the mouthpiece through Restraining to

00045 cylinders this to a latched position distance

00046 brings his blanket to the piston, in which cylinder and

00047 flask under charging the power stores in a Eder

00048 releasable latching position in the cartridge-shaped housing

00049 can be inserted the device. Here comes the ceiling

00050 a further function. Which consists in that

00051 the ceiling of the cylinder one of flow channels

00052 neighboring piercing element has to open the

00053 cartridge floor area. The corresponding perforation

00054 is already happening in the operations of the cartridge. A

00055 cartridge used in the apparatus according to claim 1 is

00056 thus advantageously characterized by a throughput

00057 stechbare bottom surface and a tear-off flag with gestalte-

00058 th head area including the demolition Banner by

00059, the opening of the mouthpiece is passed. So

00060, the cartridge until the time of application

outwardly tightly held 00,061th On the other hand, it may

but 00062 also be advantageous, the local piercing

00063 to automatically cause. In such a case it is

00064 accordingly favorable if the mouthpiece in the region of

00065 an adjacent opening of flow channels throughput

00066 piercing post to open the cartridge ceiling surface ascending

00067 points. While the discharged by the air flow

00068 substance in the nasal application powerfully in the

00069 nasal cavity is "shot", this possibly under Einbezie-

00070 hung also the sinuses, oral application can be carried out with one and the same device 00071, wherein

00072, this solution is characterized by the

00073 mouthpiece attachable dispensing spout with in coat

00074 wall thereof provided opening for sucking a

00075 supplement airflow. About the sucking so the

reached 00,076 bronchi. In order for a pre-holing the cylinder

00077 derraum versus about herausrieselnden substances

kept free 00078, is further proceeded so that the

00079 piercing element associated in the ceiling of the cylinder

00080 flow channels form a Umlenktasche. Latter

00081 acts as a so simplest reached gutter. Continue

00082 is a favorable feature of the invention is that

00083 restraining between the mouthpiece and cylinder preferential

00084, by means of an O-ring is achieved. Thus the

00085 cylinder in a combination of frictional and shape

00086 dragged conclusion, the latter particularly pronounced,

00087 when the mouthpiece-side opposing face, a suitable

00088 comprises the annular groove. The appropriate plant docking of

00089 mouthpiece is achieved in handling easily,

00090 if the cap-shaped mouthpiece into Bajonettverschluß-

00091 position to the cartridge-like housing can be brought.

00092 This very easily repeatable Closure is weitest-

00093 continuously familiar technical layman, so that the

00094 access, the loading and so quickly feasible

00095 is. consists respect to the design of the latching means

00096 a particularly favorable solution is that a lower

00097 nose of the piston skirt falling like a trip ratchet

00098 of the housing passes over. Appropriately, the event type

00099 nose realized from the end of a cut-free tongue.

00100 A good guide for the axially spaced verlagerba-

00101 ren parts with simple means achieved by a

00102 central guide tube of the housing, in the interior

00103 part of the length of the power storage spring is located. The other

00104 partial length disappears in the end support for the force

00105 accumulator spring forming hollow piston shaft. A WEI 00106 tergehende function falls the guide tube yet characterized to 00107, that the upper end of the central guide tube 00108 forms an extension-limiting abutment. Further, there is a ready-00109 still advantageous embodiment of the specific Kartu00110 by a preferably transverse wall cladding 00111-creasing of the cartridge. This increases the grip at 00112 assignment and removal and, moreover, keeps the Konta00113 minationsfläche smaller. The corresponding grip 00114 of an optimized maintenance is characterized in that the entering into a free-standing position 00115 portion of the cylinder eben00116 if a preferably transverse Mantelwand- 00117 has grooving. Finally, there still than 00118 proves advantageous that the bullet-shaped device can be clipped to a 00119 the cartridge receiving reservoir housing. 00120 latter can be closed and accommodate a sliding lid 00121, the daily dosage amount covering, whether 00122 cartridges containing in a powder or liquid containing in a 00123 form. The advantageous discharge spout cation for oral Appli00124 can to stay in the reservoir housing 00125 by finally in this regard is still so vorge00126 assumed that a portion of the interior of the housing is Vor00127 rats mer separated to form a divided Aufnahmekam00128 for the dispensing spout. This is done simply by forming a partition wall 00129. 00130 00131 The object of the invention below with reference to a 00132 graphically illustrated Ausführungsbeispie00133 les explained in more detail. It shows: 00134 00135 Fig 1 the device according to the invention in a perspective representation 00136, a storage casing arranged releasably zuge00137;. . 00138 00139 Figure 2 is enlarged the device in vertical section, compared with FIG 1 00140, and cartridge equipped with in-00141 charging power storage spring. 00142 00143 Fig 3 is a section as Figure 2, but after the triggering of the mechanism 00144..; 00145 00146 4 shows the device in side view. 00147 00148 Fig 5 is a plan view of the device. 00149 00150 Fig 6, the lower view thereof. . A longitudinal section 00153 through the device when depressing in a latched Abstand00154 position, favorite cylinder, 00155 00156 Fig 8 is a vertical section th through the head portion 00157 of the device under illustrating a Varian00158 thereof 00151 00152 Fig 7 in an exploded view and the cartridge. 00159 00160 Figure 9 shows the plan view of FIG. 8. FIG. 00161 00162 Figure 10 is a plan view of a further modification. . 00163 00164 Figure 11 is a plan view corresponding to Figure 10, but with an open cartridge 00165, 00166 00167 Fig 12 is a plan view of a head 00168 respectively nose of the tool by attaching to-00169 ordbare discharge spout..; . 00170 00171 13 the same in side view; 00172 00173 Fig 14, the dispensing spout in a twisted by 90 ° 00174 side view. added plug technically associated dispensing spout 00177 00178 00179 in vertical section and Fig. 16 a of the FIG. 15 view corresponding to 00180 00175 00176 90 ° Fig. 15, the device in which only the discharge spout is 00181 illustrates in section. 00182 00183 The illustrated as a whole with G designated 00184 device is used for airborne output kartuschenum00185 connected Substances 1. The discharge of the metered 00186 content using the device G is powerful and zielge00187 directed. The air flow is not biased; Rather 00,188 ready-held air as if Ben quickly ausgescho00189. 00190 00191 The corresponding substance 1, liquid or pulvri00192 ger type cartridge containing bears the reference K. 00193 00194 00195 The device G is constructed shock in ease of use and back with respect to a simple Kartu00196. 00197 It is primarily used for nasal application, but can not find 00,198 by an additional component for an oral application 00199 application. 00200 00201 The corresponding drug is accommodated in the elongated gestal00202 ended cartridge K. The accommodation space 00203 2 of the cartridge tube shaped basically 00204 K is at both ends sealed foil. Accordingly 00205 is a pierceable bottom surface 3 and an area 4 from Decken00206. The ceiling surface 4 faces a mouthpiece of the device 5 00207 G; the bottom surface 3, however, 00208 points in the direction of a piston / cylinder unit E, the 00209 heart of the device G. 00210 00211 One of the two surfaces of the cartridge can also be K 00212 molded same. 00213 00214 The jacket wall of the cartridge K has a grooving 6 00,215th Which is transverse to the longitudinal central axis xx of the 00216 basically rotationally symmetrical apparatus constructed G. lying 00217 In this axis, the cartridge K also sets einge00218. It is a rich scoring six made. The 00219 increases grip and reduces the Kontaminati00220 onsfläche. 00221 The roping 6 forming annular grooves have an axial length greater than the measured in this direction 00222 length or width pen are retarded Ringrip00223. In contrast, the end-ring fins are much thicker. 00224 your end edges have a chamfer. 00225 00226 The airborne application the effecting air flow 00227 is produced in the back of the cartridge K. The diesbezügli00228 che cylinder chamber is designated by 7. Its cylinder 8 00229 receives a stop-limited slidable piston 9 00,230th The latter is under effect of the piston 9 00231 RAST-cancellation release of the same in the direction of the mouthpiece 5 00232 driving force accumulator spring 10. 00233 is a helical compression spring. 00234 whose one terminal turn is supported on a floor 11 of the device G 00235. The other terminal spring coil 00236 finds its abutment in the back 12 of the piston 9 forms a Besag00237 the force Saves Eder 10 there 00238 centering receiving recess ter back 12th The end face of the piston 9 is 00239, to a Randlippung, plan. 00240 00241 the major part of an axially directed Aufnah00242 me the energy storing spring 10 forms a central leadership 00243 extension tube 13 of the device G. The so a spring chamber 00244 alternate end guide tube 13 is formed the floor. 11 00245 It is radially spaced from an inner wall 14 00246 a cartridge-shaped housing 15 of the device G. The 00247 base 11 is of her se 15 clipped into the patronenformige Gehäu00248. The Klipsstelle means 16 00249 00250 At the discharge of the air contained in the cylinder chamber 7 00251 a mouth piece 5 facing the ceiling 17 of the Zylin00252 is the provided with a central aperture 18. 8 00253 In this free-standing projects a piercing thorn 19 00254 It may be a cross-profiled in cross section 00255 mandrel. The pointed out mouthpiece other. 00256 00257 The free end of the piercing mandrel 19 projects into a 00258 receiving chamber 20. In this, the lower end of the 00259 cartridge K is inserted frictionally, whereby there is 00260 inevitably leads to a spike penetration, thus opening 00261 of the bottom surface 3 of the cartridge K. 00262 00263 The cartridge K occurs in a willing stresses 00264 again annullable clamping tight fit, wherein the Durchtritts- is given 00265 away for accommodating space 2 towards because the 00266 internal wall of the accommodation space 2 chen in wesentli00267 with the inner wall of the opening 18 of the 00268 receiving chamber 20 aligned and the piercing thorn 19 00269 is clearly wandungsbeabstandet. Added to the cross-sectional reduction is also due to the 00270 th angedeute00271 profiling thereof 19 00272 00273 The receiving chamber 20 is formed from a fixed to the ceiling 17 00274 plugged intermediate part 21st It is designed to cup-shaped 00,275th Its pot rim holds an O-ring 22 in position 00276. Whose material is gurπmielastisch. 00277 00278 The O-ring 22 is located in a radial groove lying 00279 whose piston-side boundary due to a periph- 00280 ren shoulder 23 of the cylinder is given. 8 00281 00282 While the receiving chamber 20 is formed by a in the direction 00283 of the mouthpiece 5 of the intermediate portion 21 protruding Ring00284 wall circumscribes a thereof in the opposite direction 00285, so the cylinder chamber-side annular wall, the zentra00286 le aperture 18 00287 00288 Under this, the central opening forming 18 00289 annular wall extending a rotationally symmetrical ge00290 staltete Umlenktasche 24. the latter acts as Fangrin00291 ne for the perforation at the bottom surface 3 about aus00292 passing powdery substance 1. the Umlenktasche 24 is designed plate-shaped 00293 basically. Your nose über00294 dominates the cylinder chamber side facing annular wall of the Durch00295 refraction 18 edge and wall are radially spaltbeabsta- 00296 friend. 00297 00298 Said Umlenktasche 24 is in flow communication with 00299 25 peripherally located flow channels latter 00300 can be determined by radial ribs which rialbrücke a Mate00301 form between the central region of the ceiling 17 00302 and the periphery of the cylinder. 8 A total of 00,303, this gives us a rotationally symmetrical S-Flow 00304 fugue. guessed about in the Umlenktasche 24 Pulverparti00305 kel are entrained totally in the output direction. 00306 also the underside of the ceiling 17 is flat. 00307 00308 To complete the receiving chamber 20 of the Innen00309 is used space of the mouthpiece. 5 00310 latter forms the length predominating portion of the Aufnahmekam00311 mer of the cartridge K. This section bears the reference numeral 20 00312 '. The lower with assignment of the mouth piece 00313 5 via the free-standing remaining portion of Kartu00314 cal K. It is between combined so endanschlagbegrenzt. 00315 In this end position assignment according basic version of the device 00316 G, figures 1 to 7, and in a sense, the foil-sealed ceiling surface is 4 00318 00317 Fig. 15, dompenetriert. For this purpose, the mouthpiece 5 in the region of a 00319 nozzle 26 upstream opening 27 gleich00320 if a piercing spike 28. Also can be profiled cross- 00,321 and goes cartridge side in a training 00322 spitzung over. The Board position of the sharpened end 00323 of this piercing mandrel 28 is arranged so that with the proper 00324 enclosing the cartridge K, defi00325 defined by terminal supporting shoulders of the unit G, the opening 00326 is also ensured there. The Durchstech00327 mandrel 28 is surrounded by flow channels 29th 00328 00329 The nozzle 26 forming part is prepared separately 00330 and accordingly may form different Ausgabe00331 be used adjusted. 00334 00332 00333 The basically designed like a cap mouthpiece 5 includes an annular seal 30th The latter describes 00335 the lower input of the section 20 'and is supported there 00336 against an internal shoulder 31 of the mouthpiece 5 from. The 00337 sealing counter-seat surface forming the annular top 00338 of the flat bottom plate of the cup-shaped intermediate part 21 00339 00340 00341 The cap-shaped mouthpiece 5 can be operationally define 00342 on cartridge-shaped housing 15th This purpose is served 00343 a bayonet closure means 32. The typical angular 00344 slot of the bayonet device 32 is realized in the substantially cylindrical cap wall of the mouthpiece 00346 5 00345 and designated 33rd A 00347 associated locking pin 34 is seated on the circumferential wall of the housing 15. The 00348 bayonet closure means 32 is provided in pairs 00,349th The advantage is in the diametrical orien00350. 00351 00352 The mouthpiece 5 is the handle for charging the 00353 force accumulator spring 10 00354 00355 purpose, the piston 9 associated cylinder 8 00356 is displaced by means of the mouth piece 5 relative to the piston 9 in an 00357 chip standby position (see FIG. FIG. 7). 00358 This entraining advancing the cylinder 8 00359 happens after emptying of the unit G. The Entleerungsstel00360 lung is apparent from FIG. 3. the mouthpiece 5, starting from this position emptying Ent00361 rotated and pulled 00362, that the locking pin 34 can emerge from the angular slot 33 00,363th In this way, the mouthpiece 5 00364 is out of connection with the attack bullet-shaped Gehäu00365 se 15 brought. Further pulling on the mouthpiece 5 in the piston 9 00366 a direction opposite to the cylinder 8 is dragged 00,367th 00368 00369 The results in entrainment of the function of the O-ring 00370 22 - and thus the cylinder 8 - is in über00371 windbarer locking connection with the mouthpiece. 5 The 00372 mouthpiece 5 includes an annular groove 35 in its interior kappenformigen 00373 to the appropriate place. The corresponding 00374 latching stop is such that the frictional forces occurring during withdrawal of the Zylin00375 DERS 8 finally the überwun00376; only in a pull-out end position may be willing 00377 emphasizes separate the mouthpiece 5 from the projecting part drawn 00378. 8 00379 00380 With the help of the mouthpiece 5, the unit will now Zylin00381 8 / piston 9 moves in the energy storing spring Aufladestel- 00382 lung, which is done by pushing in the cylinder 8 into the housing 00383 15th The cylinder 8 occurs 00384 in a latched position spaced y his blanket 17 00385 to the piston 9, in which cylinder 8 and piston are pushed 9 under 00386 recharging the power storing spring 10 in a releasable 00387 latching position in the patronenformige housing 15 of the 00388 device G. 00389 00390 The continuous in the direction of the bottom 11 00391 return displacement of the piston 9 goes active on the in this direction 00392 free end face 36 of the cylinder 8. The latter 00393 interacts with a steep flank 37 at the piston skirt 38 zusam00394 men. Said steep flank is like the end face 36 00395 perpendicular to the longitudinal central axis xx of the device G. 00396 (37) is part of a nose 39 of the piston shaft 00397 38. Reference is made to FIG. 2. The unspoilt there 00398 light gap is only for clarity. 00399 00400 In charging position (Fig. 2), the accumulator spring 10 00401 is the open part of the cylinder space 7 00402 leave-piston 9 with respect to the lower tab 39 15. 00403 effective range of a trip latch 40 of the housing 00404 The tip of the nose is an actuating finger 41 of 00405 tripping latch 40 faces. By pressing the Auslö00406 seklinke 40 in the direction of arrow z loses the nose 00407 39 their grip on the end surface 36; the piston 9 00408 snaps into its pushing out of the air stream bewir00409 Kende, stop-limited Board position shown in FIG. 3. 00410 There, the planar end face of the piston head against 00411 entered the same kind underside of the flooring 17. So the 00412 piston 9 finds its stop here. 00413 00414 The trip latch 40 occurs after release in their from 00415 Fig. 2 apparent initial position outside the Zylin00416 derdurchmessers. 00417 00418 The nose 39 protrudes in the position according to Fig. 3 in a 00419 behind the face 36 adjoining längsgerichte00420 th alternate slot 42 of the cylinder 8. To the steep 00421 edge 37 back to the position respectively function 00422 of the power storage spring 10 is great plunger 00423 to transfer, the nose 39 00424 5 überlaufbar in the direction of the head piece through the cylinder. 8 This happens when 00,425 bringing forward of the cylinder 8, in the final phase. 00426 The Nasenücken namely has a ramp 43 00,427th Which gives the nose 39 a dowry function. The 00428 tab 39 acts like falling. The corresponding 00429 intermediate position is shown in FIG. 7, in 00430 by a dashed entry of the lower 00431 end of the cylinder 8. recognizable overflows there the 00432 lower, that is, the bottom 11 is closer to end 44 of the Aus00433 soft slot 42 aussteuernd over the run-on slope 00434 43, to then pass over the cliff edge 37th 00435 00436 The corresponding deflecting movement of the case-like projection 39 00437 acting results from the fact that the nose at the free end of a 00438 cut-free tongue 45 of the shank sits Kolben00439 38th The cut-out limit in Längen00440 direction is indicated by the 46th 00441 00442 to the corresponding deflection of the tab 39 inwardly 00443 out is located in the back of the cut-free tongue 45 00444 a broad adapted longitudinal groove 47 at one korrespondie00445 leaders jacket wall portion of the stationary central 00446 guide tube 13 00447 00448 The central guide tube 13 is also to a 00449 used another function, namely that of the Fessel00450 ung of the piston 9 in the housing 15. in concrete terms, the so-00451 from that the upper, left-hand end in the drawing 00452 of the central guide tube 13 likewise carries a nose-shaped limit stop 00453 48th This über00454 engages with a steep flank 49, the rectified 00455 end 50 of a longitudinal slot 51 of the tubular Kolben00456 shank 38. The axial length of the slot 51 berück00457 into account the 9th through y given stroke of the piston 00458 00459 00460 Moreover enters the cylinder 8 with a lateral 00461 projection 52 against a counter-shoulder of the housing 15. About 00462 here, a rotation of the parts causes 00463. The projection 52 to dive into a longitudinal groove 53 00464 in the inner wall 14 of the housing 15 °. The 00465 longitudinal groove 53 is formed continuously and sweeps 00466 end face of the housing, which area is closed by the plug-like floor 00467. 11 00468 00469 The other parts of the telescoping structural 00470 Taken instruction are secured against rotation. 00471 00472 The variant according to FIGS. 8 to 11 is in principle the same structure 00473. The numerals are applied mutatis mutandis 00474, partly without textual repetitions. 00475 Next Made there is the cartridge K. piston side 00476 closes again by a pierceable Boden00477 area 3 from. The ceiling surface 4 is on the other hand so ausgebil00478 det and arranged such that it is not exposed mouthpiece side 00479 piercing mandrel. Rather, the local end of the cartridge 00480 K by a head surface 4 'verschlos00481 sen. The latter extends over a chimney-like extension 54. 00482 This chimney or tubular sleeve-shaped extension 54 projects 00483 through an opening 55 of the mouthpiece 5 therethrough. The 00,484 full deduction is the same and done 00485 turn over shoulders. The designed in the form of a film or the like head face 00486 4 'continues in a 00487 laterally the cross-section of the extension superior 00488 outline flag 56 on. The latter tapers toward 00489 their free extension. 00490 00491 The amount of pipe-socket-like extension 54 and the 00492-free supernatant of this extension over the top, 00493, as it ausspitzende end face of the mouthpiece 5 is 00494 so chosen that the outline flag 56 impairment freely 00495 is hindurchziehbar through the opening 55th They (56) 00496 then arises overall low side again zufol00497 ge its restoring force. The necessary clearance of Öff00498 voltage 55 is by diagrammatic representation of a light 00,499 gap illustrates. 00500 00501 The local cartridge K is inserted a disc in the region of the extension 00502 54 containing the already be00503 prescribed nozzle 26 27 with opening 00504 00505 The opening of the top of this cartridge K can be as 00506 regardless of the cartridge loading operation of the device G 00507 made become. 00508 00509 Fig. 10 shows in which the cartridge K occluding 00510 head surface 4 'of predetermined breaking lines 57. There is a kreuz00511 example arrangement. The there still remained Abriß00512 end flag 56 allows for an optional handling. 00513 00514 Fig. 11 shows a by the flow pressure aufgerisse00515 ne head surface 4 ', said lines of weakness 57 ent00516 holding. 00517 00518 The highlighted grip shape of the cartridge K 00519 over a grooving 6 can the be applied also with respect to the 8 a useful counter-stop forming at 00520 handling Zylin00521. Accordingly, in this respect 00522 is therefore so proceeded that the entering into a free-standing position 00523 portion of the cylinder 8 is also a vor00524 preferably transverse shell wall-grooving 58 be00525 sits. Another type of roughening is also conceivable 00,526. 00527 00528 As shown in FIG. 1 can be removed, the unit G as described in detail above 00529 can be clipped into place on the cartridge a K aufnehmen00530 of the storage case 59. To this end it to 00531 a narrow longitudinal side to a Andockhütchen 60th In the 00532 this auspitzende to nostril size of mouth is used 00,533-piece-side area. The contrast slightly 00534 durchmesserabgesetzte collar portion of the bottom 11 is embraced by a spring clip 00535 61st The latter has a 00536-through opening 62nd Here About the device G can 00537 angling comfortable and safe and disengage again. The 00538 axial position assurance is obtained by using the 00539 collar near-stage 63 and the saturated pad of the Mund00540 piece 5 in the hopper space of Andockhütchens 60. 00541 00542 The reservoir housing 59 is true in length abge00543 to a level which takes the unit G in its basic position ein00544. Overall, slightly more than a cigarette box size is 00545 before. 00546 00547 respect to the reservoir housing 59 remains festzuhal00548 th that this is accessible through a sliding cover nutengeführten 00549 64th The latter advantageously consists of 00550 transparent or translucent material. Also, 00551 is an internal division made in such a way that 00552 a portion of the interior of the reservoir housing is separated 59 to 00553 form a divided receiving chamber 65 for a dispensing spout 00554 66th Said discharge spout 66 00555 finds its application in diagrammatic representation and 00556 Figures 12 to 16. The discharge spout 66 is there as 00557 plug-in part via the mouthpiece 5 can be slipped. Here, a 00,558-friction conclusive assignment is selected. The Aufnahmekam- 00559 mer 65 is located so that these 00560 tion of the sliding lid 64 is primarily free by opening Schiebeverlage-. 00561 00562 By putting such a discharge spout 66, the device 00563 00564 G can enabling use to be changed below a oral application. The Ausgabe00565 spout 66 is not only in this respect palatable gestal00566 tet, not ausspitzend as for nasal Applika00567 tion molded, but as realized at least in its end 00568 oval pipe socket. Additionally, there are flow-00569 technical issues considered such that the dispensing spout is 00570 hen 66 with bypass-like openings 67 verse00571. About this, the user can move using 00,572 of sucking up air. Thus, the inhaled air is the 00573 via the nozzle 26 finely dispersed in 00574 introduced mouth / pharynx substance 1 at the destination 00575 bronchi etc. transported. 00576 00577 Said openings 67 are provided in pairs. You befin00578 to be lip-away lying along the bottom or base of the discharge spout 66. 00579 00580 00581 All features disclosed are essential to the invention. In 00582, the disclosure of the application and the disclosure 00583 content of the associated / attached Priori00584 hereby incorporated Lich tätsunterlagen (copy of the prior application) vollinhalt00585 with, also for the purpose of incorporating features of these documents in claims of the present application 00586 with 00,587th

Claims

00588 ANS P RUCH E 00589 00590 1. Device (G) for the metered release of substances (1), in particular drugs 00591, from a in the unit (G) 00592 insertable cartridge (K), composed of a 00593 a moving piston (9 ) air flow formed of the 00594 through the opening (27) of the cartridge (K) umfassen00595 exits the mouthpiece (5), which mouthpiece coaxially 00596 located to the moving direction of the (of a releasable 00597 force accumulator spring 10) loaded piston (9), characterized 00598 in that the mouthpiece (5) is the handle for 00599 charging the energy storing spring (10). 00600 00601 2. Apparatus according to claim 1 or in particular according thereto, 00602 characterized in that the said piston (9) zugeord00603 designated cylinder (8) by means of the mouthpiece (5) relative 00604 to the piston (9) in a clamping position of readiness (Fig. 00605 7 is displaceable) and together with the piston (9) (in the Kraftspeicher00606 spring-charging position Fig.2). 00607 00608 3. Device according to one or more of the preceding 00609 claims or in particular according thereto, characterized gekennzeich00610 net, that the mouthpiece (5) through Restraining the cylinder 00611 (8) it into a latched position spaced (y) 00612 of its ceiling (17) for piston (9) takes, in which 00613 cylinder (8) and piston (9) to recharge the power 00614 accumulator spring (10) in a releasable locking position in 00615 the patronenformige housing (15) of the device (G) ein00616 be pushed. 00617 00618 4. Device according to one or more of the preceding 00619 claims or in particular according thereto, characterized gekennzeich00620 net that the ceiling (17) of the cylinder (8) one of 00621 flow channels (25) adjacent the piercing mandrel (19) 00622 has to open the cartridge -Bodenfläche (3).
00623 5. A cartridge (K) for use in devices (G) according to An00624 claim 1., characterized by a puncturable 00625 cartridge bottom surface (3) and one with tear-off tab (56) 00626 designed cartridge head face (4 '), the einschließ00627 Lich the tear tab (56) through the opening (55) of the 00628 can be passed the mouthpiece (5). 00629 00630 6. Device according to one or more of the preceding 00631 claims or in particular according thereto, characterized gekennzeich00632 net, that the mouthpiece (5) in the region of its opening 00633 (27) piercing one of flow channels (29) adjacent Durch00634 (28) for opening the having cartridge 00635 ceiling surface (4). 00636 00637 7. Device according to one or more of the preceding 00638 claims or in particular according thereto, characterized 00639 le through the mouthpiece (5) attachable Ausgabetül00640 (66) in the outer wall thereof provided 00641 aperture (67) for sucking a supplemental air flow. 00642 00643 8. Device according to one or more of the preceding 00644 claims or in particular according thereto, characterized gekennzeich00645 net, that the pass-through mandrel (19) in the ceiling (17) 00646 of the cylinder associated (8) flow channels (25) 00647 a Umlenktasche (24 ) form. 00648 00649 9. An apparatus according to one or more of the preceding claims or in particular according 00650, characterized gekennzeich00651 net that the restraining between the mouthpiece (5) and the Zylin00652 (8) by means of an O-ring (22) is preferably aimed er00653. 00654 00655 10. Device according to one or more of the preceding claims or in particular according 00656, characterized gekennzeich00657 net that the kappenformige mouthpiece (5) 00658-circuit position to the cartridge-like housing (15) is in bar bayonet bring00659. 00660 00661 11. Device according to one or more of the preceding 00662 claims or in particular according thereto, characterized gekennzeich00663 net that a lower nose (39) of the piston skirt (38) 00664 event like a tripping latch (40) of the housing (15) passes over the 00,665th 00666 00667 12. Device according to one or more of the preceding claims or in particular according 00668, characterized gekennzeich00669 net that the case-like nose (39) from the end of a 00670 cut-free tab (45) of the piston skirt (38) is realized 00,671th 00672 00673 13. Device according to one or more of the preceding claims or in particular according 00674, in (G) 00676 00675 located by a central guide tube (13) of the casing inside which a partial length of the energy storing spring 00677 (10). 00678 00679 14. Device according to one or more of the preceding claims or in particular according 00680, characterized gekennzeich00681 net, that the upper end of the central guide tube 00682 (13) forms an extension limit (48). 00683 00684 15. Device according to one or more of the preceding claims or in particular according 00685, 00686 characterized by a preferably transverse wall cladding 00687-creasing (6) of the cartridge (K). 00688 00689 16. Device according to one or more of the preceding 00690 claims or in particular according thereto, characterized gekennzeich00691 net that the entering into a free-standing layer portion 00692 of the cylinder (8) has also a preferably cross-references 00693 running jacket wall-grooving (58). 00694 00695 17. Device according to one or more of the preceding claims or in particular according 00696, characterized gekennzeich00697 net that the patronenformige device (G) to a Kartu00698 the rule (K) receiving reservoir housing (59) can be clipped 00,699th 00700 00701 18. Device according to one or more of the preceding 00702 claims or in particular according thereto, characterized gekennzeich00703 net, that a portion of the interior of Vorratsgehäu00704 ses (59) to form a divided receiving chamber 00705 (65) for the discharge spout (66) is separated.
PCT/EP1998/001167 1997-03-03 1998-03-03 Metered dispensing device for substances WO1998039043A1 (en)

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