EP1027165B1 - Application method for at least two different media and dispenser therefor - Google Patents

Abstract

In order to enable application of a dry i.e. powdery or granulated active substance, said substance is kept apart from a liquid supply in a dispenser. The powder is discharged with the help of said liquid during application. The liquid serves as a carrier for the active substance and is mixed with the liquid to varying degrees prior to discharge. The dispenser (11) has a liquid chamber (21) in an ampoule (19) which is provided with a closure stopper (26) which can be pierced. The liquid flow which is released upon actuation penetrates into a medium storage chamber (43), is mixed with the medium (51) therein and exits via an opened discharge outlet (44) in the form of a spray mist, jet or drop.

Description

The invention relates to the application of media, in particular pharmaceutical products in atomized jet or Teardrop shape according to claim 1 and a dispenser therefor according to claim 6.

WO 96/24439 shows a disposable dispenser in which one containing a liquid medication through a rubber stopper sealed glass ampoule inserted into a sleeve is in via a predetermined breaking connection with a donor Connection is established. This has a protruding nose adapter with an atomizing nozzle at the end. A central one Shaft or stamp inside this adapter carries in the In the middle is a needle that is pressed in by manual pushing the sleeve in the adapter pierces the rubber plug. The shaft then pushes the rubber plug in as a piston the ampoule into it and thus generates the application pressure.

This disposable atomizer is very reliable and for that Application of liquid medication ideally suited especially for those who are absorbed very quickly by the body should be, e.g. through the nasal mucosa, too Intolerance to the digestive tract associated with oral Admission could be avoided. However, there is Medications that are not stable in liquid form for long periods are.

Although there are many suggestions for powder application and metering there is problematic and usually only through Whirling up in larger amounts of air possible. So divorce but many areas of application because of a targeted application is hardly possible.

US 3,756,390 relates to an injection syringe, the two spaces separated by a perforated film for Has liquid and powder. Includes the powder chamber In the nozzle, after removing a protective cap, a needle can be used. After breaking the release film the two media are mixed together. After that the protective cap removed, the needle inserted and after the Air-out spraying performed the injection. A similar The procedure is in US 3,595,439 A for a mixed cartridge for dental 2-component material.

GB 1 453 591 describes an ampoule which is pierceable End plug for a liquid chamber and has an intermediate plug to a powder chamber. At the Inserting a needle, for example on a drip the intermediate plug is pushed out, so that both media can mix with each other. By An extra channel can then be added to the mixture in the drip chamber enter.

JP 8-280807 A shows an adapter that is one of a Has aluminum foil sealed liquid chamber. This can be placed on a container of freeze-dried Pharmaceutical are put on. On the other side of the an adapter sealed with a screw cap Pump atomizer can be plugged on, with its suction tube punctures the aluminum foil and so liquid chamber and Powder container connects together. This from three separate Dispenser to be joined before use not very helpful for uncomplicated use.

TASK AND SOLUTION

The object of the invention is a method and a dispenser to apply at least two different media create with which also solid-state media reliable and can be dosed and applied specifically.

The invention provides a method in which a liquid as a carrier medium for a particulate solid medium is used and the separately stored media only be mixed together before they are applied. Under the The term particulate solid medium is to be understood that it is not as a gas, liquid, paste or in massive Shape, but usually dry with some Flowability or flowability is present, in particular is powdery to granular. So it's possible keep the two media separate from each other, whereby the active ingredient mostly in the particulate medium dry form may be present. It can e.g. is a pharmaceutical product that is in the form of a freeze-dried powder is present. Just before the application, it is mixed with a liquid which serves as a carrier medium. It can either be a slurry (Dispersion) or a solution that is then applied together, preferably as a spray, but also as a drop or jet.

Besides the advantage that the product is in the dry powder form is more durable, the advantage arises that the Liquid can be chosen so that the absorption by the mucous membranes are particularly encouraged. On preservatives can be dispensed with.

The particulate solid medium should best be powder, but at least flowable or free-flowing and be easily miscible with the liquid, so in the relative short, available time an intimate mixture or even solution in the liquid is possible. But it is possible that the particles also in the form of so-called Microcapsules are present, i.e. from a skin covered Ingredients exist.

The most direct and immediate application after mixing is possible if the liquid is under a discharge pressure introduced into the solid medium and the resulting Mixture is output under this application pressure. It is but also possible to mix in one application immediately upstream mixing phase. Thereby can e.g. be made sure that all liquid first introduced into the space containing the solid medium before the application starts. This can be particularly true solution-active mixtures already for a solution, at least but for a good slurry of the solid medium in the Provide liquid. The liquid acts as a carrier for the solid, but can also be pharmaceutical Have effects or contribute to them.

According to the invention is between the mixing phase and the application phase a pressure point for the actuating force to be overcome manually provided so that automatically certain stopover results. The solid state medium is mostly the space in which it is stored is not complete to complete. This becomes a partially relatively large volume share of gas, for example of air or one that Stabilization of the product-promoting inert gas. When mixing, this gas can with the introduction of the Liquid are compressed, so that finally when Spreading, i.e. opening the solid-state memory or a certain initial pressure already exists in a mixing room, e.g. ensures good atomization right from the start.

A dispenser is also proposed which has a liquid space, Pressure generating means for generating an application pressure and for conveying the liquid into one of the liquid space separate media storage for a powdered or free-flowing solid medium and an outlet opening for the mixture. With the pressure generating agent it can are a piston pump, the cylinder of which Liquid space can be.

It is possible the liquid space and the media storage before actuating the dispenser externally and against each other keep tightly closed and only by actuation to connect both with each other and with the outlet opening. This can be done by piercing membrane-like pistons or Container walls, by lip valves or the like.

The building of pressure points, the building of certain Allow minimum actuaries both before Start of operation as well as between the mixing and spreading phases take place, e.g. by snap connections, preferred but through predetermined breaking points, i.e. through actuation forces destructible material bridges.

In the case of such dispensers, each dispensing batch has a separate one Have containers of one at a time or in a few consecutive Operations is carried out, the Opening of a media room mostly through a thin hollow needle, for example, a steel needle made by beveling is sharpened and usually a very small one Has a diameter of less than 1 mm. It is in a shaft added, which usually also the pierceable piston in the Push cylinder in. Around this thin and delicate needle was previously equipped with a metal adapter, which as a relatively thick solid metal ring was attached to the outside of the needle. He enabled one Attacking an assembly tool and was using a annular locking teeth pressed into the shaft (cf. WO 96/24439). This arrangement has been tried and tested because of the reliable assembly without damaging the sensitive Top considered inevitable. It requires however, the metal adapter as a separate part, what the cost and also the metal content in the otherwise almost sorted disposal dispenser increased.

It has now been found that it is possible to use the very thin and sensitive needle with the necessary tightness damage-free without attaching this adapter. It will between the entire middle area between the two ends the needle-engaging ribs of a larger hole in the Shaft inserted and at the end in a hole with a press fit pressed in, which is a lot longer than the needle diameter. It rests on one shoulder inside this hole and can thus freely to the outlet opening communicate. When inserting, the needle will be on her Tip-bearing end held by a collet that has a center pin which engages the needle and thus crushing and damaging the sensitive Tip prevented. This is important because it is damage free Tip for piercing the sealing plug as well is necessary like with an injection needle to avoid that the needle penetrates the container or piston wall Detaches particles that clog the discharge opening or even get into the patient’s airway.

These and other features go beyond the claims also from the description and the drawings, wherein the individual features individually or separately several in the form of sub-combinations in one embodiment of the invention and in other fields be and advantageous as well as protective designs can represent. The division of the application into individual sections as well Inter-headings limit those made under them Statements not in their general validity.

SHORT SCREAMING OF THE DRAWINGS

Fig. 1 und 2

Längsschnitte durch einen Spender in zwei Arbeitspositionen,

Fig. 3 und 4

Längsschnitte durch andere Ausführungsbeispiele und

Fig. 5 bis 7

drei Arbeitsstellungen eines weiteren bevorzugten Ausführungsbeispiels, jeweils im Längsschnitt.

An embodiment of the invention is shown in the drawings and is explained in more detail below. The drawings show:

1 and 2

Longitudinal cuts through a dispenser in two working positions,

3 and 4

Longitudinal sections through other embodiments and

5 to 7

three working positions of a further preferred embodiment, each in longitudinal section.

DESCRIPTION OF PREFERRED EXECUTIVE EXAMPLES

The dispenser 11 shown in FIGS. 1 and 2 is a disposable atomizer, who delivers his entire batch in one stroke.

It has a housing 12 which has an elongated adapter section 13 has. It protrudes from an oval top view epaulette-like actuation shoulder protruding on two sides 14 of the housing out in the middle. On the shoulder 14 includes an opposite one to the adapter Housing jacket 15, one each on its flatter sides Actuating cutout 16 has.

Through the actuating cutout 16 is the actuating surface 17 a sleeve 18 accessible with a finger, the one Glass ampoule 19, supported by webs 20 in the sleeve, receives which contains a liquid space 21. Sleeve 18 and Ampoules 19 have the shape of elongated, deeper, circular cylindrical Container.

To the sleeve made of plastic, thin, Web-like material bridges 22 forming predetermined breaking points Ring 23 formed, which in a snap connection 24 on the Underside of the shoulder, adjacent to the interior 25 of the essentially hollow adapter 13 is added.

The liquid space 21 in the ampoule 19 is through one a sealing plug 26 completed, the sealing on the circular cylindrical wall of the liquid space 21 abuts. It is relatively elongated and has central from each of its end faces Recesses 28, which are separated by a central web 29 are, which forms a pierceable membrane. The sleeve 18th and the ampoule 19 protrude centrally and centrally into the interior of the adapter 13 and are there with the outer wall of the Sleeve 18 and an upper flange 30 of the ampoule 19 lateral webs 31 in the interior 25 of the adapter 13, namely over the length of an actuation path.

At the end of the actuation path, a piston tappet 34 is over a ring 32, the material bridges forming predetermined breaking points 33 connected to him, recorded the inside the adapter 13 centrally until just before the ampoule 19 or its plug 26 is enough. Inside the plunger 34 A connecting channel 35 runs, which connects to the inner channel 36 a hollow plunger 37 connects, which consists of a steel needle exists, on which, facing the plug, by bevel a tip 38 is formed. The steel needle is in one relatively massive metal adapter ring 39 added to the outside has an annular, barb-like toothing. With this is in a connection to the connecting channel Opening 40 is pressed into the piston skirt 34.

The connecting shaft 34 is above its predetermined breaking ring 32 of sealing means provided in the interior 25 of the adapter 13 Guide lips 41 guided and sealed. By a sealingly attached, forming the end of the adapter 13 End cap 42 is an annular space around shaft 34 formed, the media storage 43 for a solid-state medium, for example, forms a powder. In the end cap 42 an outlet opening 44 is provided in the center, which as Spray nozzle is formed. It creates a conical one Spray jet with the help of vortex channel formation 45 on the front End of the shaft 34. This lies against the in operation Inside of the outlet nozzle 44. Spirally trained Channels cause a swirl of those flowing through them quickly Liquid or mixture.

Between the inside of the nozzle and the end face of the shaft 34 an outlet chamber 46 is formed which is opposite the media store 43 sealed by sealing lips 47 of the end cap 42 is. The outlet chamber contains adjacent to the Sealing lips overflow channels 48 in their cylindrical wall. The connecting channel 35 in the shaft 34 ends in lateral, openings 49 formed by a transverse channel on the Shaft surface.

All parts of the dispenser with the exception of the glass ampoule 19 and formed by a steel needle with a metal adapter ring Ram 37 are made of plastics. The liquid space 21 is filled with a liquid designed to when flowing out with a particulate solid medium to mix in the media storage 43 to solve this or untangle or disperse it together with to apply the liquid. The solid state medium is one pharmaceutically active substance, mostly in powder form. The Liquid mostly consists of water, which in sterile and possibly physiologically adapted to the body fluid Form is present. But there are also other liquids or possible liquid additions that are also effective of the solid-state medium promoting or triggering properties may have. It can have a two-component effect arise between the liquid and the solid medium.

1 and 2 is in the packaging, Storage and sales status in the shown in Fig. 1 Position. The liquid space 21 is with the liquid 50 filled and sealed by the plug 26. The plunger 37 is just above the web 29. Im Media storage 43 is the solid-state medium 51, but at the same time usually an even larger amount of air, the one hand through the spaces between the particles is conditional, but may also be present, so that the particles are not filled in too compactly Need to become. The media storage 43 is through the sealing lips 41 and 47 and the corresponding cylinder surfaces of the Shaft 34 tightly sealed to the outside and inside.

The elongated adapter is used to use the dispenser 11 13 brought into the appropriate dispensing position, for example inserted into a nostril. The user takes hold of the Dispenser by placing two fingers on the shoulders 14, while pressing the thumb on the operating surface 17 suppressed. It must first have a relatively high operating pressure exercise to the predetermined breaking points that the material bridges 22nd form between the ring 23 and the sleeve 18 to destroy. These also ensure tamper evidence.

Then the sleeve / ampoule 18/19 moves upwards, i.e. into the interior 25 of the adapter 13. The needle-like Tappet 37 pierces the web 29 in the plug 26 and the lower end face 52 of the shaft 34, the one somewhat has a smaller diameter than the liquid space 21 on the end face 53 of the sealing plug 26. This thereby forms the piston of a thrust piston pump, the Cylinder from the liquid chamber 21 or the glass ampoule 19 is formed.

The upward axial acting on the shaft 34 Pressure also breaks the material bridges when actuated 33, which connect the ring 32 to the shaft 34, so that the shaft 34 in Fig. 2 moves up until its upper End face with the spinal canal formation 45 on the Exhaust chamber delimiting upper end wall. In this The position is, as can be seen from FIG. 2, the connecting channel 35 through the side openings 49 with the annular media storage 43 connected, however, by the lips 41 remains sealed towards the adapter interior 25. In contrast, an upper groove 54 through an annular groove 54 Bypassed sealing lip 47 so that an outlet flow channel over the overflow channels 48 and the swirl channel formation 45 for Outlet opening (nozzle) 44 is formed.

The pressure of the stem 34 on the plug / piston 26 generates the necessary application pressure, which the liquid passes through the needle 37, the connecting channel 35 and the openings 49 in promotes the media storage 53. There she mixes with solid state medium 51, e.g. by designing the Media storage and / or the openings 49, for example through their inclination to create a swirl, can be promoted. Then the resulting mixture applied from the outlet opening, especially in a fine spray Shape. The sealing lips 47 form together with the upper piston section 47a or the groove 54, the exhaust valve. The dispenser is designed to be used with a single, however here two-stage actuation stroke the whole in it batch of Apply solid medium and liquid.

Except for the differences described below, the Structure of the dispenser according to Fig. 3 the same as that in the Figures 1 and 2 shown. On its description Reference and the same reference numerals are used.

An ampoule 19 is accommodated in the sleeve 18, which is longer is than that of Fig. 1. It contains in axial succession both the liquid space 21 and the media store 43a. Accordingly, there is 19 in the ampoule except for the sealing piston sealing the media reservoir 43a here 26 a the liquid space 21 from the media storage 43a separating intermediate piston 55, the one shown in Fig. 3 Hibernation locks the two rooms apart. To connect them is a in the wall of the ampoule 19th molded connection channel 35a provided, the outlet in the media store 43a, however, in the idle state from the intermediate piston 55 is completed.

The shaft 34 is in a nozzle section 56 of the adapter 13 used sealingly, the one piece with the housing 12th (and thus with the adapter 13) is formed. The hemisphere Adapter end 57 is also integral with this formed in which the nozzle-shaped outlet opening 44th is provided. The shaft contains on its upper face the spinal channel formation interacting with the outlet nozzle 45. The plunger 37 is received in the shaft, which is formed by a steel needle, almost by the entire shaft 34 to just before its upper end face enough. The needle, which is usually an outer diameter of less than a millimeter and a correspondingly small one Has wall thickness, as well as to form a sharp and burr-free 38 is very carefully sharpened, is without the 1 adapter 39 shown directly in a bore 58 of the Shaft inserted. This hole has one larger diameter than the needle 37, but this leads by e.g. four radially inwards from the inner wall of the bore projecting webs 59 which in the region of the end face 52 of the Start shaft 34 with an insertion bevel 60. You worry for exact centering and prevent buckling of the thin needle when inserting. They range from the free end of the Shaft up to a fitting bore 61, i.e. about the biggest and especially important for preventing buckling middle area of the needle.

At the top, i.e. from the tip 28 is the end Needle 37 is pressed into a fitting bore 61, which are so dimensioned is that it allows a tight fit of the needle in it. A shoulder 62 in this fitting hole forms one upper stop for pressing in the needle. The fitting hole includes the upper end of the needle closely over a length that is greater than a multiple, e.g. Five times the outer diameter the needle. The fitting hole stands with its upper one End with the outlet chamber 46 in communication.

The dispenser consists of very few parts. In the one piece Housing into which the outlet opening 44 is directly molded is the shaft 34 with the needle mounted therein used. The donor is completed by the Unit sleeve / ampoule 18/19 with plug 26 and Intermediate piston 55 which is the liquid and media chamber split off.

The assembly of the dispenser according to Fig. 3 is very simple. By the novel design of the shaft 34 can without the needle the annular adapter 39 according to FIG. 1 can be mounted. The Ribs 59 guide the needle as it enters bore 58, without opposing too much resistance in the longitudinal direction. Only when the needle is over most of its length is guided between the ribs, it enters the fitting hole 61 a where they are sealing and also mechanically against peeling is pressed in securely. The needle is how to get out of the Drawing recognizes only a relatively small part of theirs Length, usually less than a third, from the shaft 34 out. So the section most prone to buckling, which is in the middle of the needle when applying the force to press it into the fitting bore 61 already secured against buckling between the ribs.

It is particularly important that the sensitive tip 28 of the The needle is not damaged during the press-in process. Therefore is used with a tool that the needle of grips outside with a kind of collet (in the out of the shaft outstanding area), but also a center pin has, which engages in the needle bore and so the needle secures against pinching and damage to the tip.

The pre-assembled shaft can then partially with its upper bevelled end pressed into the socket 56 become.

The pre-assembled unit consisting of a sleeve and an inserted ampoule 19 is attached to the housing 12 via the snap lock 24. Before that the ampoule was first with the liquid filled, whereupon the intermediate piston 55 attached and then the solid medium into the media storage above 43a was filled. After that, the plug became 26 put on.

When actuated, as in FIGS. 1 and 2, the predetermined breaking point 22 to achieve a sufficient initial pressure destroyed, which ensures that the user is actuating with a certain force and speed too really ends. An interruption would, for example, cause the atomizer to drip and possibly impair the mixture of substances or the prevent full spreading.

Then the plunger 37 (needle) pierces the web 29 in the Piston 26 and opens it mainly through the interior the hollow needle 37 formed outlet channel 36 opposite Media storage 43a. The shaft 34 presses the piston 26 below and compresses that in the media storage 43a Solid state medium 51 and the air contained therein (or a corresponding inert gas). This also becomes the intermediate piston 55 pushed down and gives the connecting channel 35a free in the ampoule wall. This could also be caused by a corresponding elevation of this wall be formed, which then too would release an overflow channel on both sides. The liquid 50 flows from the liquid space 21 into the Media storage 43a mixes there with the medium 51 and with the appropriate discharge pressure via the needle bore 36 passed to the outlet opening 44. The glides Unit sleeve / ampoule 18/19, guided by the webs 31, in Inside 25 of the nose adapter 13 upwards. Here too is a complete discharge of the two media (plus the third medium "air") possible. The air also forms one Pre-compression, which promotes the start of the atomization phase. If necessary, the arrangement could also be made such that the medium is arranged in the area of the ampoule near the bottom and the liquid over it. In this case the First pour the liquid down, there with the Mix medium and then again through the liquid chamber flow through to the outlet. This can make a special one intimate mixture can be brought about.

4 shows a particularly simple embodiment. In an ampoule 19, which are also made of plastic can and has the shape of a particularly deep bowl is a liquid piston 64 sealing with piston lips performed, in one piece at the lower end of a piston rod 65 is trained. A subsequent chamber 63 takes the ball on when pushed out and a spinal canal / nozzle assembly 80 similar to the nozzle 44 with swirl channel 45 ensures a beam distribution that promotes mixing of the media optionally with swirl and atomization in the media storage 43b.

It has a continuous central bore 66, in the upper Section as a closure valve a ball 67 is pressed. The upper end of the piston rod 65 is of a sleeve-like Overlapped adapter cap 13b, so that between the upper End face 68 of the piston rod 65 and the interior 69 of the Adapter cap 13b of the media storage 43c is formed. A Outlet opening 44 formed at the end of the adapter cap can be used as Spray or drip nozzle can be formed. It is from one tearable closure 70 closed, for example one sealed aluminum foil.

The adapter cap 13b has lateral actuation shoulders 14b and reaches into the inside of the ampoule with its lower part 19 on, i.e. it leads to the cylinder wall 27. From the Wall of the adapter cap 13b notched spring tabs 71 form together with a groove in the cylinder wall 27 on the one hand a snap lock that secures the idle state and prevents the adapter cap 13c from being pulled off the ampoule, and on the other hand they provide the necessary build-up of operating force before the start of the operation. By a barb-like Execution can prevent peeling and the Measure the actuation force build-up in a predetermined manner become.

This dispenser consists of a few relatively simple plastic parts, a piece of film and a small steel or Plastic ball. You could also by piercing or by Liquid pressure tearing membrane to be replaced.

During manufacture, the liquid space 21 is filled with liquid 50 filled, the piston / piston rod unit 64, 65 inserted and then the adapter cap 13b, with the medium 51st filled, used.

To use the dispenser according to FIG. 4, the Tear-off closure 70 torn off, so that the outlet opening 44 is open. Then, overcoming the pressure point, the generate the spring tabs 71, the piston 64 in the sleeve 19th (or vice versa). The resulting fluid pressure pushes the ball 67 out of the overflow channel 66 into the chamber 63. The liquid splashes with a swirl in the sharp Jet or atomized into the media storage 43b, mixed there with the medium 51 and emerges as a mixture of the Outlet opening 44 from.

The individual rooms are also one below the other before being operated and completely closed off from the outside. The Zipper 70 could also be pressure dependent opening valve to be replaced, but what about a disposable dispenser is usually not necessary. With this or the following embodiment according to FIGS. 5 to 7 is also possible Use exhaust valve that the user only after a Mixing phase is consciously opened, e.g. a rotary slide valve, by twisting the top section of the adapter cap 13, 13b is actuated relative to the rest of the housing. By the rotation could also be released a stop that the piston rod during the first actuation step (Mixing), prevented the mixture from being applied immediately. The time required to operate the rotary valve could e.g. ensure the solution of the powder in the liquid.

The same also applies to the exemplary embodiments according to FIGS. 5 to 7 reference to the detailed description of FIG. 1 to 3. Only the differences are described below.

The main difference is that of sleeve 18 and Ampoule 19 existing unit containing the media. The Sleeve 18, which by means of the predetermined breaking ring 32 on the housing 12th attached, contains the liquid space 21 in it lower area facing its bottom 17. There is a Molded plastic plunger 37c, the central in the sleeve after protrudes above and has a cross-shaped cross section.

An inner sleeve 19c is a piston-like seal in the sleeve used that has a pierceable membrane on its bottom 29c. This sleeve closes the liquid space sealing from above. It is by means of a predetermined breaking ring 32 inserted into the interior 25 of the nose adapter 13. The predetermined breaking ring works with material bridges 33 as described. The Inner sleeve 19c forms a cylinder for a storage / mixing chamber 43c, the upward from an inverted sleeve-shaped, serving as a piston plug 26c is completed.

In the course of the manufacture of the dispenser 11 according to FIGS. 5 to 7 the liquid 50 is filled into the liquid space 21 and the solid medium 50 in the media storage 43c. This is closed by the plug 26c. The inner sleeve 19c is inserted into the sleeve 18 like a piston, which is the cylinder of a second thrust piston pump forms and closes the liquid space 21 on this dispenser upwards.

When actuated, the predetermined breaking lock 32 breached. The plunger 37c then penetrates through the membrane 29d and places over those formed in its cross-section Channels the connection between the liquid space 21 and the media storage 43d. The liquid space 21 reducing piston-like lower part of the inner sleeve 19c conveys the liquid 50 into the media storage space 43c which enlarges itself by being under the resulting Media pressure pushes the plug 26c up.

Fig. 6 shows the end of this mixing phase, in which the liquid and the solid medium mix. she will ended in that, as Fig. 6 shows, the bottom of the inner sleeve 19c abuts the bottom 17 of the sleeve 18. Then it is only a common mixing room 43c is also present. The previously in Media room 43c existing air can vary depending on Resistance of the plug 26c more or less compress and maintain a basic pressure in the mixing chamber receive.

The predetermined breaking closure 32 can be set so that the User when he reaches the position shown in Fig. 6 has to apply new, increased pressure. Thereby it is ensured that there is sufficient in the mixing chamber 43c Time to mix, if necessary dissolve the ingredients arises.

7 shows, the predetermined breaking lock 32 breaks thereafter, the needle 37 penetrates through the bottom 29d of the plug 26c, which is thereafter from the end face 52 of the shaft 34 is contacted and in the manner of a piston in one Pump sleeve forming inner sleeve 19c is pressed. As a result, the mixture 50/51 from the mixing chamber 43d the outlet channel formed by the needle bore 36 to the outlet opening 44 transported and there under the application pressure atomized or otherwise spent. As with FIG. 3 the application phase could be described by means of Rotation to be released in addition to or instead of Breaking ring 32 to be limited in time. It is too possible, instead of the piercing needle, a rotary slide valve use that is opened by this rotation.

In this embodiment, the mixing phase of the Application phase is spatially and temporally separated, although everything essentially follows one another, so there is no danger that the solid medium in the Mixed phase is damaged. It is also possible to use both of these Distribute phases over two different actuation strokes instead of them, as in FIGS. 5 to 7, in two axially one behind the other horizontal lifting sections. It is also possible, by appropriate subdivision or succession of A batch premixed in two in a first stroke successive partial spreading strokes in order to for example, one drug in succession in both nostrils to apply to a patient. Also a multiple donor or reloadable dispenser as described above Principle is possible.

Claims (15)

1. Method for the application of at least two different media by manual discharge actuation,

   1.1 in which one liquid (50) is used as the carrier medium for a particulate solid medium (51) and

   1.2 the distinct, separately stored media (50, 51) are mixed with one another in a mixing phase by the discharge actuation prior to their application,
   characterized in that

   1.3 the mixing phase and the application phase are demarcated against one another through the overcoming of an increased actuating force and

   1.4 the resulting mixture is atomized under an application pressure.
2. Method according to claim 1, characterized in that the solid medium (51) is a particulate, pharmaceutical product, particularly intended for optional absorption by body mucosa and is preferably in the form of a freeze-dried powder.
3. Method according to claim 1 or 2, characterized in that mixing takes place directly prior to application.
4. Method according to one of the preceding claims, characterized by an additional actuation, such as the rotation of two parts against one another, between the mixing phase and the application phase.
5. Method according to one of the preceding claims, characterized in that during mixing a gas optionally stored together with the solid medium (51) is compressed with the introduction of the liquid (50).
6. Dispenser with

   6.1 a liquid chamber (2) for storing a liquid (50),

   6.2 means for producing an application pressure and for feeding the liquid to a discharge orifice (44),
   characterized in that

   6.3 a medium reservoir (43) is provided for a particulate solid medium (51),

   6.4 feeding means for feeding the liquid are constructed in the medium reservoir (43) separate from the liquid chamber (21),

   6.5 prior to the actuation of the dispenser (11), the liquid chamber (21) and medium reservoir (43) are tightly sealed to the outside and against one another and only as a result of the actuation are connected to one another by means of a connecting channel (35, 36, 66) and to the discharge orifice (44) by means of a discharge channel (48).
7. Dispenser according to claim 6, characterized in that the pressurizing means contain a thrust piston pump, whose cylinder is preferably formed by the liquid chamber (21) and in particular the piston (26) of the thrust piston pump is irreversible for forming a disposable dispenser and/or between the liquid chamber (21) and medium reservoir (43) is constructed a shutoff member (27, 29; 41) opening as a result of the dispenser actuation, particularly due to the application pressure.
8. Dispenser according to one of the claims 6 to 7, characterized by pressure point means (23, 32, 71), which make the actuation of the dispenser dependent on reaching a predetermined actuating pressure, which preferably contain preset breaking points (22, 33) and are in particular provided both for the actuation of the pressurizing means and for the opening of the medium reservoir (43), as well as for delivering the liquid into the medium reservoir (43).
9. Dispenser according to one of the claims 6 to 8, characterized in that for connecting the medium chambers or reservoirs to one another and to the discharge orifice at least one perforating element is provided, which contains a needle-like ram (37) having at least one liquid channel and which preferably perforates a piston of the thrust piston pump constructed as a closing plug (26) and is received in a shaft (34), which comes into contact with the piston for the displacement thereof.
10. Dispenser, according to one of the claims 6 to 9, characterized in that the ram (37) for perforating a closure of a medium chamber (21) is constituted by a thin, hollow steel needle, preferably having an external diameter below 1 mm and a bevelled tip (38), which is inserted in adapter-less manner in a shaft (34) of the dispenser (11) carrying it, it being sealingly inserted at its end remote from the tip (38) in a fitting bore (61), whose length is greater and in particular at least twice greater than the needle external diameter, it engages with this end on a shoulder (62) in the fitting bore (61) limiting the pressing-in length and in its central area is guided until it passes out of the shaft (34) over a length which is a multiple, preferably more than five times the needle external diameter, between ribs (59) in the interior of a larger bore (50), which has at its start an insertion bevel (60) for the needle and preferably the interior of the hollow needle forms a receptacle for a holding and filling pin of a gripping device, which externally grips the needle from the outside in collet-like manner for pressing in.
11. Dispenser according to one of the claims 6 to 10, characterized in that the medium reservoir (43) is formed by a chamber connected to an outlet channel and which is in particular sealed by a closure, e.g. a slide valve (41, 47) opened on producing the application pressure or by separate manual actuation.
12. Dispenser according to one of the claims 6 to 11, characterized in that the liquid chamber (21) and medium reservoir (43a) are arranged in axially succeeding manner in a cylinder-like container (19) and are sealed with respect to one another and to the outside by preferably closing plug-like pistons (26, 55) and in particular at least one of the pistons opens by means of a slide or perforation control dependent on the piston position a connecting channel (35a) between the liquid chamber (21) and medium reservoir (43a).
13. Dispenser according to one of the claims 6 to 12, characterized in that for connecting the medium chambers and for mixing the media with one another there is at least one first actuating stroke or actuating stroke portion and for application purposes a second actuation stroke or stroke portion, which arc in particular demarcated with respect to one another by a manually separately operable stop and/or by pressure point means (32).
14. Dispenser according to one of the claims 6 to 13, characterized in that the medium chambers (21, 43c) are arranged in axially succeeding manner and preferably a separating element (19c, 29c) is placed displaceably between them and/or at least one of the medium chambers (43c) can be enlarged for an at least partial volume adaptation to the volume of the mixture, e.g. by the displacement of a piston (26c).
15. Dispenser according to one of the claims 8 to 14, characterized in that with the connecting channel (35, 36, 66) between the liquid chamber (21) and the medium reservoir is associated a guide device (80) for accelerating, whirling up and/or distributing the liquid jet entering the medium reservoir.

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