WO1998031791A1 - Iga1 protease fragment as carrier peptide - Google Patents

Iga1 protease fragment as carrier peptide Download PDF

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Publication number
WO1998031791A1
WO1998031791A1 PCT/EP1998/000294 EP9800294W WO9831791A1 WO 1998031791 A1 WO1998031791 A1 WO 1998031791A1 EP 9800294 W EP9800294 W EP 9800294W WO 9831791 A1 WO9831791 A1 WO 9831791A1
Authority
WO
WIPO (PCT)
Prior art keywords
amino acid
peptide
seq
polysaccharide
positions
Prior art date
Application number
PCT/EP1998/000294
Other languages
English (en)
French (fr)
Other versions
WO1998031791A9 (en
Inventor
Mark Achtmann
Monique Moreau
Original Assignee
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin
Pasteur Merieux Serums Et Vaccins S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to NZ331968A priority Critical patent/NZ331968A/xx
Priority to KR1019980707480A priority patent/KR20000064740A/ko
Priority to EP98904105A priority patent/EP0895537B1/de
Priority to JP10533684A priority patent/JP2000507274A/ja
Priority to AT98904105T priority patent/ATE283914T1/de
Priority to CA2249409A priority patent/CA2249409C/en
Application filed by Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin, Pasteur Merieux Serums Et Vaccins S.A. filed Critical Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin
Priority to DE69827880T priority patent/DE69827880T2/de
Priority to AU62116/98A priority patent/AU6211698A/en
Publication of WO1998031791A1 publication Critical patent/WO1998031791A1/en
Priority to NO19984365A priority patent/NO322265B1/no
Publication of WO1998031791A9 publication Critical patent/WO1998031791A9/en
Priority to US10/841,324 priority patent/US7235242B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Detergent Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PCT/EP1998/000294 1997-01-21 1998-01-20 Iga1 protease fragment as carrier peptide WO1998031791A1 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
KR1019980707480A KR20000064740A (ko) 1997-01-21 1998-01-20 담체 펩티드로서의 아이쥐에이1 프로테아제 단편
EP98904105A EP0895537B1 (de) 1997-01-21 1998-01-20 Iga1-protease fragment als trägerpeptid
JP10533684A JP2000507274A (ja) 1997-01-21 1998-01-20 キャリヤーペプチドとしてのｉｇａ１プロテアーゼフラグメント
AT98904105T ATE283914T1 (de) 1997-01-21 1998-01-20 Iga1-protease fragment als trägerpeptid
CA2249409A CA2249409C (en) 1997-01-21 1998-01-20 Iga1 protease fragment as carrier peptide
NZ331968A NZ331968A (en) 1997-01-21 1998-01-20 Iga 1 protease fragment as carrier peptide, its conjugation to a polysaccharide derived from neisseria meningitidis</ital>
DE69827880T DE69827880T2 (de) 1997-01-21 1998-01-20 Iga1-protease fragment als trägerpeptid
AU62116/98A AU6211698A (en) 1997-01-21 1998-01-20 Iga1 protease fragment as carrier peptide
NO19984365A NO322265B1 (no) 1997-01-21 1998-09-18 Antigen baerer, fremgangsmate for dens fremstilling, dens anvendelse, konjugat samt vaksine.
US10/841,324 US7235242B2 (en) 1997-01-21 2004-05-07 IgA1 protease fragment as carrier peptides

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97100883.4 1997-01-21
EP97100883 1997-01-21

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09142970 A-371-Of-International 1998-01-20
US10/841,324 Division US7235242B2 (en) 1997-01-21 2004-05-07 IgA1 protease fragment as carrier peptides

Publications (2)

Publication Number Publication Date
WO1998031791A1 true WO1998031791A1 (en) 1998-07-23
WO1998031791A9 WO1998031791A9 (en) 1998-12-17

Family

ID=8226386

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/000294 WO1998031791A1 (en) 1997-01-21 1998-01-20 Iga1 protease fragment as carrier peptide

Country Status (14)

Country Link
US (1) US7235242B2 (de)
EP (1) EP0895537B1 (de)
JP (1) JP2000507274A (de)
KR (1) KR20000064740A (de)
AT (1) ATE283914T1 (de)
AU (1) AU6211698A (de)
CA (1) CA2249409C (de)
DE (1) DE69827880T2 (de)
DK (1) DK0895537T3 (de)
ES (1) ES2234095T3 (de)
NO (1) NO322265B1 (de)
NZ (1) NZ331968A (de)
PT (1) PT895537E (de)
WO (1) WO1998031791A1 (de)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19821859A1 (de) * 1998-05-15 1999-12-09 M Alexander Schmidt Darstellung immunogener (Kapsel-)Polysaccharid-Konjugate durch orientierte Kupplung synthetischer T-Zell-Epitope zur Erzeugung von Vakzinen gegen N.meningitidis
US10087221B2 (en) 2013-03-21 2018-10-02 Sanofi-Aventis Deutschland Gmbh Synthesis of hydantoin containing peptide products
US10450343B2 (en) 2013-03-21 2019-10-22 Sanofi-Aventis Deutschland Gmbh Synthesis of cyclic imide containing peptide products

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0254090A1 (de) * 1986-07-02 1988-01-27 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Verfahren zur gentechnologischenGewinnung von Proteinen unter Verwendung gramnegativer Wirtzellen
EP0326111A2 (de) * 1988-01-29 1989-08-02 New York Blood Center, Inc. Peptid-Derivate, immunogenisch gemacht bei Verabreichung zusammen mit Alaun als Zusatzmittel
WO1990011367A1 (en) * 1989-03-17 1990-10-04 Mogens Kilian IMMUNOGLOBULIN A1 PROTEASES (IgA1 PROTEASES), METHOD OF GENE-TECHNOLOGICALLY PRODUCING THIS TYPE OF ENZYME AND VACCINES CONTAINING THE ENZYMES AND FRAGMENTS THEREOF FOR IMMUNIZING AGAINST BACTERIAL MENINGITIS AND OTHER DISEASES CAUSED BY IgA1 PROTEASE-PRODUCING BACTERIA
EP0429816A1 (de) * 1989-10-31 1991-06-05 F. Hoffmann-La Roche Ag Vakzin-Zusammensetzung mit einem nichtimmunosuppressiven T-Zellepitopbestandteil

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0254090A1 (de) * 1986-07-02 1988-01-27 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Verfahren zur gentechnologischenGewinnung von Proteinen unter Verwendung gramnegativer Wirtzellen
EP0326111A2 (de) * 1988-01-29 1989-08-02 New York Blood Center, Inc. Peptid-Derivate, immunogenisch gemacht bei Verabreichung zusammen mit Alaun als Zusatzmittel
WO1990011367A1 (en) * 1989-03-17 1990-10-04 Mogens Kilian IMMUNOGLOBULIN A1 PROTEASES (IgA1 PROTEASES), METHOD OF GENE-TECHNOLOGICALLY PRODUCING THIS TYPE OF ENZYME AND VACCINES CONTAINING THE ENZYMES AND FRAGMENTS THEREOF FOR IMMUNIZING AGAINST BACTERIAL MENINGITIS AND OTHER DISEASES CAUSED BY IgA1 PROTEASE-PRODUCING BACTERIA
EP0429816A1 (de) * 1989-10-31 1991-06-05 F. Hoffmann-La Roche Ag Vakzin-Zusammensetzung mit einem nichtimmunosuppressiven T-Zellepitopbestandteil

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
J. ROMERO AND I. OUTSCHOORN: "Current status of meningococcal group B vaccine candidates", CLINICAL MICROBIOLOGY REVIEWS, vol. 7, no. 4, October 1994 (1994-10-01), pages 559 - 575, XP000676353 *
LOMHOLT H ET AL: "COMPARATIVE CHARACTERIZATION OF THE IGA GENE ENCODING IGA1 PROTEASE IN NELSSERIA MENIGITIDIS, NEISSERIA GONORRHOEAE AND HAEMOPHILUS INFLUENZAE", MOLECULAR MICROBIOLOGY, vol. 15, no. 3, 1 January 1995 (1995-01-01), pages 495 - 506, XP002003045 *
LOMHOLT H: "Molecular biology and vaccine aspects of bacterial immunoglobulin A1 proteases.", APMIS 104 (SUPPL. 62). 1996. 1-28. ISSN: 0903-4641, XP000676380 *
SIBER G R: "PNEUMOCOCCAL DISEASE: PROSPECTS FOR A NEW GENERATION OF VACCINES", SCIENCE, vol. 265, no. 5177, 2 September 1994 (1994-09-02), pages 1385 - 1387, XP000461837 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19821859A1 (de) * 1998-05-15 1999-12-09 M Alexander Schmidt Darstellung immunogener (Kapsel-)Polysaccharid-Konjugate durch orientierte Kupplung synthetischer T-Zell-Epitope zur Erzeugung von Vakzinen gegen N.meningitidis
US10087221B2 (en) 2013-03-21 2018-10-02 Sanofi-Aventis Deutschland Gmbh Synthesis of hydantoin containing peptide products
US10450343B2 (en) 2013-03-21 2019-10-22 Sanofi-Aventis Deutschland Gmbh Synthesis of cyclic imide containing peptide products

Also Published As

Publication number Publication date
NO984365L (no) 1998-11-19
US20040203108A1 (en) 2004-10-14
ATE283914T1 (de) 2004-12-15
JP2000507274A (ja) 2000-06-13
US7235242B2 (en) 2007-06-26
NO322265B1 (no) 2006-09-04
KR20000064740A (ko) 2000-11-06
AU6211698A (en) 1998-08-07
EP0895537B1 (de) 2004-12-01
DE69827880D1 (de) 2005-01-05
CA2249409A1 (en) 1998-07-23
NO984365D0 (no) 1998-09-18
PT895537E (pt) 2005-04-29
CA2249409C (en) 2010-10-26
ES2234095T3 (es) 2005-06-16
NZ331968A (en) 1999-05-28
DE69827880T2 (de) 2005-11-03
DK0895537T3 (da) 2005-03-29
EP0895537A1 (de) 1999-02-10

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