WO1998027206A3 - Polypeptides de la famille 'basic helix-loop-helix' bhlh, sequences d'acides nucleiques correspondantes - Google Patents

Polypeptides de la famille 'basic helix-loop-helix' bhlh, sequences d'acides nucleiques correspondantes Download PDF

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Publication number
WO1998027206A3
WO1998027206A3 PCT/FR1997/002368 FR9702368W WO9827206A3 WO 1998027206 A3 WO1998027206 A3 WO 1998027206A3 FR 9702368 W FR9702368 W FR 9702368W WO 9827206 A3 WO9827206 A3 WO 9827206A3
Authority
WO
WIPO (PCT)
Prior art keywords
helix
polypeptides
loop
basic
nucleic acid
Prior art date
Application number
PCT/FR1997/002368
Other languages
English (en)
Other versions
WO1998027206A2 (fr
Inventor
Christine Icard-Liepkalns
Jacques Mallet
Philippe Ravassard
Original Assignee
Rhone Poulenc Rorer Sa
Icard Liepkalns Christine
Jacques Mallet
Philippe Ravassard
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to SK818-99A priority Critical patent/SK81899A3/sk
Priority to BR9713968-8A priority patent/BR9713968A/pt
Priority to HU0001184A priority patent/HU224305B1/hu
Priority to CA002275454A priority patent/CA2275454A1/fr
Priority to IL13030297A priority patent/IL130302A0/xx
Priority to AU56673/98A priority patent/AU732438B2/en
Application filed by Rhone Poulenc Rorer Sa, Icard Liepkalns Christine, Jacques Mallet, Philippe Ravassard filed Critical Rhone Poulenc Rorer Sa
Priority to JP52741598A priority patent/JP2001510464A/ja
Priority to EP97952961A priority patent/EP0946724A2/fr
Publication of WO1998027206A2 publication Critical patent/WO1998027206A2/fr
Publication of WO1998027206A3 publication Critical patent/WO1998027206A3/fr
Priority to NO993029A priority patent/NO993029L/no
Priority to US09/595,947 priority patent/US6998474B1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/028—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a herpesvirus

Abstract

La présente invention se rapporte à une nouvelle protéine de type bHLH et à la séquence nucléique codante correspondante. Elle vise également des vecteurs d'expression intégrant ladite séquence et l'utilisation de cette séquence ou protéine à des fins thérapeutiques.
PCT/FR1997/002368 1996-12-19 1997-12-19 Polypeptides de la famille 'basic helix-loop-helix' bhlh, sequences d'acides nucleiques correspondantes WO1998027206A2 (fr)

Priority Applications (10)

Application Number Priority Date Filing Date Title
BR9713968-8A BR9713968A (pt) 1996-12-19 1997-12-19 Polipeptìdeo do tipo bhlh dotado de uma atividade transcricional, sequência de ácidos nucleicos, vetor, utilização de polipeptìdeos, composição farmacêutica, e, utilização de uma sequência
HU0001184A HU224305B1 (hu) 1996-12-19 1997-12-19 "Basic Helix-Loop-Helix" (bHLH) családba tartozó polipeptidek és a megfelelő nukleinsav-szekvenciák
CA002275454A CA2275454A1 (fr) 1996-12-19 1997-12-19 Polypeptides de la famille "basic helix-loop-helix" bhlh, sequences d'acides nucleiques correspondantes
IL13030297A IL130302A0 (en) 1996-12-19 1997-12-19 Polypeptides of the "basic-helix-loop-helix" bHLH family and corresponding nucleic acid sequences
AU56673/98A AU732438B2 (en) 1996-12-19 1997-12-19 Polypeptides of the "basic-helix-loop-helix" bHLH family, corresponding nucleic acid sequences
SK818-99A SK81899A3 (en) 1996-12-19 1997-12-19 Polypeptides of the "basic-helix-loop-helix" bhlh family, corresponding nucleic acid sequences
JP52741598A JP2001510464A (ja) 1996-12-19 1997-12-19 「塩基性ヘリックス・ループ・ヘリックス」ｂＨＬＨファミリーのポリペプチド、対応する核酸配列
EP97952961A EP0946724A2 (fr) 1996-12-19 1997-12-19 Polypeptides de la famille "basic helix-loop-helix" bhlh, sequences d'acides nucleiques correspondantes
NO993029A NO993029L (no) 1996-12-19 1999-06-18 Polypeptider fra familien "Basic-Helix-Loop-Helix" bHLH, og de tilsvarende nukleinsyresekvenser
US09/595,947 US6998474B1 (en) 1996-12-19 2000-06-16 Polypeptides of the “basic helix-loop-helix” bHLH family, corresponding nucleic acid sequences

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR96/15651 1996-12-19
FR9615651A FR2757524B1 (fr) 1996-12-19 1996-12-19 Polypeptides de la famille bhlh, sequences d'acides nucleiques correspondantes

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09331356 A-371-Of-International 1997-12-19
US09/595,947 Continuation-In-Part US6998474B1 (en) 1996-12-19 2000-06-16 Polypeptides of the “basic helix-loop-helix” bHLH family, corresponding nucleic acid sequences

Publications (2)

Publication Number Publication Date
WO1998027206A2 WO1998027206A2 (fr) 1998-06-25
WO1998027206A3 true WO1998027206A3 (fr) 1998-10-01

Family

ID=9498862

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR1997/002368 WO1998027206A2 (fr) 1996-12-19 1997-12-19 Polypeptides de la famille 'basic helix-loop-helix' bhlh, sequences d'acides nucleiques correspondantes

Country Status (15)

Country Link
US (1) US6998474B1 (fr)
EP (1) EP0946724A2 (fr)
JP (1) JP2001510464A (fr)
KR (1) KR20000057698A (fr)
AU (1) AU732438B2 (fr)
BR (1) BR9713968A (fr)
CA (1) CA2275454A1 (fr)
CZ (1) CZ219499A3 (fr)
FR (1) FR2757524B1 (fr)
HU (1) HU224305B1 (fr)
IL (1) IL130302A0 (fr)
NO (1) NO993029L (fr)
SK (1) SK81899A3 (fr)
WO (1) WO1998027206A2 (fr)
ZA (1) ZA9711401B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPP495598A0 (en) * 1998-07-30 1998-08-20 Walter And Eliza Hall Institute Of Medical Research, The A novel regulatory molecule and genetic sequences encoding same
JP2003530066A (ja) * 1999-04-06 2003-10-14 ザ・レジェンツ・オブ・ザ・ユニバーシティー・オブ・カリフォルニア ヒトニューロゲニン３をコードするヌクレオチド配列
EP1354889B1 (fr) * 2000-12-27 2008-04-23 Sumitomo Chemical Company, Limited Complexe d'activation de transcription et son utilisation
US20150315607A1 (en) * 2014-01-15 2015-11-05 Academia Sinica Mutated nucleotide molecule, and transformed plant cells and plants comprising the same

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995030693A1 (fr) * 1994-05-06 1995-11-16 Fred Hutchinson Cancer Research Center Proteines et genes de differentiation neurogene (neuro d)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5695995A (en) 1994-05-06 1997-12-09 Fred Hutchinson Cancer Research Center Neurogenic differentiation (neurod) genes
US6566496B1 (en) * 1996-09-27 2003-05-20 California Institute Of Technology Neurogenin

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995030693A1 (fr) * 1994-05-06 1995-11-16 Fred Hutchinson Cancer Research Center Proteines et genes de differentiation neurogene (neuro d)

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
EMBL databank accession number Y09167 06-11-96 *
RAVASSARD P ET AL: "Relax, a novel rat bHLH transcriptional regulator transiently expressed in the ventricular proliferating zone of the developing central nervous system.", J NEUROSCI RES, APR 15 1997, 48 (2) P146-58, UNITED STATES, XP002072616 *
SHIMIZU C ET AL: "MATH-2, a mammalian helix-loop-helix factor structurally related to the product of Drosophila proneural gene atonal, is specifically expressed in the nervous system.", EUR J BIOCHEM, APR 1 1995, 229 (1) P239-48, GERMANY, XP002039567 *
SOMMER L ET AL: "neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS.", MOL CELL NEUROSCI, 1996, 8 (4) P221-41, UNITED STATES, XP002072615 *

Also Published As

Publication number Publication date
FR2757524A1 (fr) 1998-06-26
ZA9711401B (en) 1998-06-25
EP0946724A2 (fr) 1999-10-06
HU224305B1 (hu) 2005-07-28
IL130302A0 (en) 2000-06-01
KR20000057698A (ko) 2000-09-25
JP2001510464A (ja) 2001-07-31
BR9713968A (pt) 2000-04-11
SK81899A3 (en) 2000-05-16
CA2275454A1 (fr) 1998-06-25
HUP0001184A3 (en) 2002-01-28
AU5667398A (en) 1998-07-15
CZ219499A3 (cs) 1999-10-13
NO993029L (no) 1999-08-16
FR2757524B1 (fr) 1999-01-29
US6998474B1 (en) 2006-02-14
AU732438B2 (en) 2001-04-26
WO1998027206A2 (fr) 1998-06-25
HUP0001184A2 (hu) 2000-08-28
NO993029D0 (no) 1999-06-18

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