WO1998027114A3 - Antigenes de surface mammaliens et reactifs associes - Google Patents

Antigenes de surface mammaliens et reactifs associes Download PDF

Info

Publication number
WO1998027114A3
WO1998027114A3 PCT/US1997/023321 US9723321W WO9827114A3 WO 1998027114 A3 WO1998027114 A3 WO 1998027114A3 US 9723321 W US9723321 W US 9723321W WO 9827114 A3 WO9827114 A3 WO 9827114A3
Authority
WO
WIPO (PCT)
Prior art keywords
cell surface
mammalian cell
surface antigens
related reagents
reagents
Prior art date
Application number
PCT/US1997/023321
Other languages
English (en)
Other versions
WO1998027114A2 (fr
Inventor
Daniel M Gorman
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Priority to AU57058/98A priority Critical patent/AU5705898A/en
Publication of WO1998027114A2 publication Critical patent/WO1998027114A2/fr
Publication of WO1998027114A3 publication Critical patent/WO1998027114A3/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention concerne des gènes purifiés codant pour un antigène de surface de lymphocyte T de mammifère, des réactifs associés, comprenant des protéines purifiées, des anticorps spécifiques et des acides nucléiques codant pour ledit antigène. Des procédés d'utilisation desdits réactifs et des kits de diagnostic sont également décrits.
PCT/US1997/023321 1996-12-17 1997-12-16 Antigenes de surface mammaliens et reactifs associes WO1998027114A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU57058/98A AU5705898A (en) 1996-12-17 1997-12-16 Mammalian cell surface antigens; related reagents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3360196P 1996-12-17 1996-12-17
US60/033,601 1996-12-17

Publications (2)

Publication Number Publication Date
WO1998027114A2 WO1998027114A2 (fr) 1998-06-25
WO1998027114A3 true WO1998027114A3 (fr) 1998-10-22

Family

ID=21871343

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/023321 WO1998027114A2 (fr) 1996-12-17 1997-12-16 Antigenes de surface mammaliens et reactifs associes

Country Status (2)

Country Link
AU (1) AU5705898A (fr)
WO (1) WO1998027114A2 (fr)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6689579B1 (en) 1996-10-25 2004-02-10 Human Genome Sciences, Inc. Polynucleotides encoding neutrokine-α
US6812327B1 (en) 1996-10-25 2004-11-02 Human Genome Sciences, Inc. Neutrokine-alpha polypeptides
CA2232743A1 (fr) * 1997-04-02 1998-10-02 Smithkline Beecham Corporation Tl5, homologue tnf
CA2292835A1 (fr) * 1997-06-06 1998-12-10 Regeneron Pharmaceuticals, Inc. Membre ntn-2 de la famille des ligands du facteur de necrose tumorale (tnf)
WO1998055620A1 (fr) * 1997-06-06 1998-12-10 Regeneron Pharmaceuticals, Inc. Element ntn-2 de la famille des ligands du tnf
AU9376498A (en) * 1997-09-05 1999-03-22 University Of Washington Tumor necrosis factor family receptors and ligands, encoding nucleic acids and related binding agents
EA200000311A1 (ru) * 1997-09-12 2000-10-30 Апотек Р Энд Д Са Новый белок иммунной системы - кау
JP2002503444A (ja) * 1997-11-26 2002-02-05 イーライ・リリー・アンド・カンパニー リガンドファミリー遺伝子
US6297367B1 (en) 1997-12-30 2001-10-02 Chiron Corporation Polynucleotide encoding TNFL1
AU2093499A (en) * 1997-12-30 1999-07-19 Chiron Corporation Members of tnf and tnfr families
US7488590B2 (en) 1998-10-23 2009-02-10 Amgen Inc. Modified peptides as therapeutic agents
GB9828628D0 (en) * 1998-12-23 1999-02-17 Glaxo Group Ltd Novel ligand
US7833529B1 (en) 1999-01-07 2010-11-16 Zymogenetics, Inc. Methods for inhibiting B lymphocyte proliferation with soluble ztnf4 receptor
US20030095967A1 (en) 1999-01-25 2003-05-22 Mackay Fabienne BAFF, inhibitors thereof and their use in the modulation of B-cell response and treatment of autoimmune disorders
HUP0105283A3 (en) 1999-01-25 2004-08-30 Biogen Idec Ma Inc Cambridge Baff, inhibitors thereof and their use in the modulation of b-cell response
US6475986B1 (en) * 1999-02-02 2002-11-05 Research Development Foundation Uses of THANK, a TNF homologue that activates apoptosis
JP2003526330A (ja) * 1999-02-23 2003-09-09 ヒューマン ジノーム サイエンシーズ, インコーポレイテッド ニュートロカイン−αおよびニュートロカイン−αスプライス改変体
JP2002540791A (ja) * 1999-04-05 2002-12-03 インサイト・ファーマスーティカルズ・インコーポレイテッド 免疫系の分子
CA2370562A1 (fr) * 1999-04-09 2000-10-19 Human Genome Sciences, Inc. 49 proteines secretees humaines
US20030022233A1 (en) * 1999-04-30 2003-01-30 Raymond G. Goodwin Methods of use of the taci/taci-l interaction
WO2000068378A1 (fr) * 1999-05-06 2000-11-16 National Jewish Medical And Research Center Molecules d'acide nucleique, proteines et recepteurs tall-1, et procedes d'utilisation
PL211786B1 (pl) 1999-08-17 2012-06-29 Apoxis Sa Zastosowanie przeciwciała oraz polipeptydu
UA74798C2 (uk) 1999-10-06 2006-02-15 Байоджен Айдек Ма Інк. Спосіб лікування раку у ссавця за допомогою поліпептиду, що протидіє взаємодії april з його рецепторами
CA2897626C (fr) 2000-02-11 2020-03-24 Biogen Idec Ma Inc. Polypeptide heterologue de la famille tnf
ATE511857T1 (de) 2000-02-16 2011-06-15 Genentech Inc Anti-april monoklonaler antikörper und deren verwendung zur behandlung von immunerkrankungen oder krebs
US20020086018A1 (en) 2000-05-12 2002-07-04 Theill Lars Eyde Methods and compositions of matter concerning APRIL/G70, BCMA, BLYS/AGP-3, and TACI
ES2609016T3 (es) 2000-06-16 2017-04-18 Human Genome Sciences, Inc. Anticuerpos que se unen inmunoespecíficamente a BLyS
US7220840B2 (en) 2000-06-16 2007-05-22 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to B lymphocyte stimulator protein
AU2001288260A1 (en) * 2000-08-15 2002-03-13 Human Genome Sciences, Inc. Neutrokine-alpha and neutrokine-alpha splice variant
US20030091565A1 (en) 2000-08-18 2003-05-15 Beltzer James P. Binding polypeptides and methods based thereon
UA83458C2 (uk) 2000-09-18 2008-07-25 Байоджен Айдек Ма Інк. Виділений поліпептид baff-r (рецептор фактора активації в-клітин сімейства tnf)
ES2387546T3 (es) 2001-05-11 2012-09-25 Amgen Inc. Péptidos y moléculas relacionadas que se unen a TALL-1
EA007275B1 (ru) 2001-05-24 2006-08-25 Займодженетикс, Инк. Слитые белки taci-иммуноглобулина
AR035119A1 (es) 2001-08-16 2004-04-14 Lilly Co Eli Anticuerpos humanos antagonistas anti-htnfsf13b
AU2004233164B2 (en) 2003-03-28 2009-10-08 Biogen Ma Inc. Truncated BAFF receptors
KR20060027801A (ko) 2003-06-05 2006-03-28 제넨테크, 인크. B 세포 장애에 대한 조합 요법
EP1709072A1 (fr) * 2004-01-29 2006-10-11 Genentech, Inc. Variants du domaine extracellulaire de bcma et utilisations de ceux-ci
BRPI0516297A (pt) 2004-10-05 2008-09-02 Genentech Inc métodos de tratamento de vasculite e artigos de fabricação
EP2332563A3 (fr) 2004-10-13 2013-03-13 The Washington University Utilisation de BAFF pour traiter la sepsie
WO2006067210A1 (fr) 2004-12-23 2006-06-29 Laboratoires Serono S.A. Polypeptides bcma et leurs utilisations
AU2006278227B2 (en) 2005-08-09 2011-10-20 Ares Trading S.A. Methods for the treatment and prevention of abnormal cell proliferation using TACI-fusion molecules
CA2618765A1 (fr) 2005-08-09 2007-02-15 Zymogenetics, Inc. Procedes destines au traitement des malignites des lymphocytes b au moyen d'une molecule de fusion taci-ig
US9168286B2 (en) 2005-10-13 2015-10-27 Human Genome Sciences, Inc. Methods and compositions for use in treatment of patients with autoantibody positive disease
MY149159A (en) 2005-11-15 2013-07-31 Hoffmann La Roche Method for treating joint damage
AU2006318539B2 (en) 2005-11-23 2012-09-13 Genentech, Inc. Methods and compositions related to B cell assays
WO2007123765A2 (fr) 2006-03-31 2007-11-01 Human Genome Sciences Inc. NEUTROKINE-ALPHA et variant d'epissage de la neutrokine-alpha
KR20090016707A (ko) 2006-05-15 2009-02-17 아레스 트레이딩 에스.에이. Taci­ig 융합 분자를 사용하여 자가면역 질병을 치료하는 방법
WO2010075249A2 (fr) 2008-12-22 2010-07-01 Genentech, Inc. Méthode de traitement de la polyarthrite rhumatoïde avec des antagonistes de cellules b
CN102597268B (zh) 2009-09-03 2017-09-22 弗·哈夫曼-拉罗切有限公司 用于治疗、诊断和监控类风湿性关节炎的方法
WO2012118750A2 (fr) 2011-02-28 2012-09-07 Genentech, Inc. Marqueurs biologiques et procédés de prédiction de réponse à des antagonistes de lymphocytes b
US9458246B2 (en) 2013-03-13 2016-10-04 Amgen Inc. Proteins specific for BAFF and B7RP1
JOP20140087B1 (ar) 2013-03-13 2021-08-17 Amgen Inc بروتينات مخصصة ل baff و b7rp1 وإستخداماتها

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998018921A1 (fr) * 1996-10-25 1998-05-07 Human Genome Sciences, Inc. Neutrokine alpha

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998018921A1 (fr) * 1996-10-25 1998-05-07 Human Genome Sciences, Inc. Neutrokine alpha

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
EMBL DATABASE; EMEST6:HS307C08B; ACCESSION-NO.: D79690, 7 February 1996 (1996-02-07), XP002073749 *
EMBL DATABASE; EMEST8:HS88288; ACCESSION-NO.: R16882, 22 April 1995 (1995-04-22), XP002073748 *

Also Published As

Publication number Publication date
WO1998027114A2 (fr) 1998-06-25
AU5705898A (en) 1998-07-15

Similar Documents

Publication Publication Date Title
WO1998027114A3 (fr) Antigenes de surface mammaliens et reactifs associes
CA2263129A1 (fr) Antigenes de surface de cellules mammaliennes et reactifs qui y sont lies
EP1114864A3 (fr) Antigènes de surface de cellules de mammifères
WO1997021812A3 (fr) Chemokine mammifere ccf8 et recepteur de chemokine cckr3
MY157028A (en) Mammalian cytokine, related reagents
WO1995018826A3 (fr) Antigenes a ctla-8 de primates purifiee et reactifs correspondants
WO2000042188A3 (fr) Cytokines de mammiferes liees a l'interleukin-17, polynucleotides les codant et leurs utilisations
WO1998024906A3 (fr) Genes isoles de monocytes de mammifere et reactifs associes
WO1998001557A3 (fr) Reactifs apparentes a des chemokines mammaliennes
EP1942114A3 (fr) "Cytokines de mammifères ; réactifs et procédés associés"
WO1998011226A3 (fr) Chemokines de mammiferes et reactifs apparentes
WO1998039421A3 (fr) Proteinase mammaliennes, oxydoreductase, proteines de liaison avec gtp et reactifs correspondants
AU1825097A (en) Mammalian cx3c chemokine genes
WO1998032858A3 (fr) Chemokines de mammiferes, recepteurs, reactifs, et modes d'utilisation
WO1998023750A3 (fr) Chemokines de mammiferes
AU1695595A (en) Mammalian thymokine genes
EP0997476A3 (fr) Anticorps contre un antigène de cellules Langerhans mammifères et leurs utilisations
WO1999047673A3 (fr) Genes de proteines membranaires mammiferes isoles, et reactifs associes
EP1867720A3 (fr) Antigènes de surface des cellules des mammifères à codage génétique purifié ; protéines et anticorps
WO1998031810A3 (fr) Chemokines de mammiferes, recepteurs, reactifs, utilisations
WO2002068596A3 (fr) Cytokines de mammifere, reactifs associes
WO1998023747A3 (fr) Genes isoles de cellules dendritiques de mammiferes et reactifs correspondants
WO2001036463A3 (fr) Genes de mammifere, reactifs associes et procedes
WO2000034335A3 (fr) Genes mammiferes et reactifs connexes
WO2003022992A3 (fr) Genes mammiferes et reactifs associes

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AU AZ BA BB BG BR BY CA CN CZ EE GE GW HU ID IL IS JP KG KR KZ LC LK LR LT LV MD MG MK MN MX NO NZ PL RO RU SG SI SK SL TJ TM TR TT UA UZ VN YU AM AZ BY KG KZ MD RU TJ TM

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SZ UG ZW AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AL AM AU AZ BA BB BG BR BY CA CN CZ EE GE GW HU ID IL IS JP KG KR KZ LC LK LR LT LV MD MG MK MN MX NO NZ PL RO RU SG SI SK SL TJ TM TR TT UA UZ VN YU AM AZ BY KG KZ MD RU TJ TM

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SZ UG ZW AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase