WO1998027114A3 - Antigenes de surface mammaliens et reactifs associes - Google Patents

Antigenes de surface mammaliens et reactifs associes Download PDF

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Publication number
WO1998027114A3
WO1998027114A3 PCT/US1997/023321 US9723321W WO9827114A3 WO 1998027114 A3 WO1998027114 A3 WO 1998027114A3 US 9723321 W US9723321 W US 9723321W WO 9827114 A3 WO9827114 A3 WO 9827114A3
Authority
WO
WIPO (PCT)
Prior art keywords
cell surface
mammalian cell
surface antigens
related reagents
reagents
Prior art date
Application number
PCT/US1997/023321
Other languages
English (en)
Other versions
WO1998027114A2 (fr
Inventor
Daniel M Gorman
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Priority to AU57058/98A priority Critical patent/AU5705898A/en
Publication of WO1998027114A2 publication Critical patent/WO1998027114A2/fr
Publication of WO1998027114A3 publication Critical patent/WO1998027114A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention concerne des gènes purifiés codant pour un antigène de surface de lymphocyte T de mammifère, des réactifs associés, comprenant des protéines purifiées, des anticorps spécifiques et des acides nucléiques codant pour ledit antigène. Des procédés d'utilisation desdits réactifs et des kits de diagnostic sont également décrits.
PCT/US1997/023321 1996-12-17 1997-12-16 Antigenes de surface mammaliens et reactifs associes WO1998027114A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU57058/98A AU5705898A (en) 1996-12-17 1997-12-16 Mammalian cell surface antigens; related reagents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3360196P 1996-12-17 1996-12-17
US60/033,601 1996-12-17

Publications (2)

Publication Number Publication Date
WO1998027114A2 WO1998027114A2 (fr) 1998-06-25
WO1998027114A3 true WO1998027114A3 (fr) 1998-10-22

Family

ID=21871343

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/023321 WO1998027114A2 (fr) 1996-12-17 1997-12-16 Antigenes de surface mammaliens et reactifs associes

Country Status (2)

Country Link
AU (1) AU5705898A (fr)
WO (1) WO1998027114A2 (fr)

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US6689579B1 (en) 1996-10-25 2004-02-10 Human Genome Sciences, Inc. Polynucleotides encoding neutrokine-α
US6812327B1 (en) 1996-10-25 2004-11-02 Human Genome Sciences, Inc. Neutrokine-alpha polypeptides
CA2232743A1 (fr) * 1997-04-02 1998-10-02 Smithkline Beecham Corporation Tl5, homologue tnf
CA2292835A1 (fr) * 1997-06-06 1998-12-10 Regeneron Pharmaceuticals, Inc. Membre ntn-2 de la famille des ligands du facteur de necrose tumorale (tnf)
WO1998055620A1 (fr) * 1997-06-06 1998-12-10 Regeneron Pharmaceuticals, Inc. Element ntn-2 de la famille des ligands du tnf
WO1999011791A2 (fr) * 1997-09-05 1999-03-11 University Of Washington Recepteurs et ligands de la famille du facteur de necrose tumorale, acides nucleiques codants et agents de liaison associes
WO1999012964A2 (fr) * 1997-09-12 1999-03-18 Biogen, Inc. Kay, nouvelle proteine du systeme immunitaire
WO1999026463A2 (fr) * 1997-11-26 1999-06-03 Eli Lilly And Company Gene de la famille des ligand tnf
US6297367B1 (en) 1997-12-30 2001-10-02 Chiron Corporation Polynucleotide encoding TNFL1
WO1999033980A2 (fr) * 1997-12-30 1999-07-08 Chiron Corporation Membres de familles de tnf et de tnfr
US7488590B2 (en) 1998-10-23 2009-02-10 Amgen Inc. Modified peptides as therapeutic agents
GB9828628D0 (en) * 1998-12-23 1999-02-17 Glaxo Group Ltd Novel ligand
US7833529B1 (en) 1999-01-07 2010-11-16 Zymogenetics, Inc. Methods for inhibiting B lymphocyte proliferation with soluble ztnf4 receptor
US20030095967A1 (en) 1999-01-25 2003-05-22 Mackay Fabienne BAFF, inhibitors thereof and their use in the modulation of B-cell response and treatment of autoimmune disorders
HUP0105283A3 (en) 1999-01-25 2004-08-30 Biogen Idec Ma Inc Cambridge Baff, inhibitors thereof and their use in the modulation of b-cell response
US6475986B1 (en) * 1999-02-02 2002-11-05 Research Development Foundation Uses of THANK, a TNF homologue that activates apoptosis
NZ513290A (en) * 1999-02-23 2004-05-28 Human Genome Sciences Inc Neutrokine-alpha and neutrokine-alpha splice variant
JP2002540791A (ja) * 1999-04-05 2002-12-03 インサイト・ファーマスーティカルズ・インコーポレイテッド 免疫系の分子
CA2370562A1 (fr) * 1999-04-09 2000-10-19 Human Genome Sciences, Inc. 49 proteines secretees humaines
US20030022233A1 (en) * 1999-04-30 2003-01-30 Raymond G. Goodwin Methods of use of the taci/taci-l interaction
WO2000068378A1 (fr) * 1999-05-06 2000-11-16 National Jewish Medical And Research Center Molecules d'acide nucleique, proteines et recepteurs tall-1, et procedes d'utilisation
EE05673B1 (et) 1999-08-17 2013-08-15 Biogen, Inc. BAFF-retseptor (BCMA), immunoregulatoorne agens
UA74798C2 (uk) 1999-10-06 2006-02-15 Байоджен Айдек Ма Інк. Спосіб лікування раку у ссавця за допомогою поліпептиду, що протидіє взаємодії april з його рецепторами
AU3495301A (en) 2000-02-11 2001-08-20 Biogen Inc Heterologous polypeptide of the tnf family
DE60028830T2 (de) 2000-02-16 2007-01-18 Genentech, Inc., South San Francisco Anti-april antikörper und hybridomazellen
WO2001087979A2 (fr) 2000-05-12 2001-11-22 Amgen Inc. Methodes et compositions associees a april/g70, bcma, blys/agp-3, et taci
US7220840B2 (en) 2000-06-16 2007-05-22 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to B lymphocyte stimulator protein
KR101287395B1 (ko) 2000-06-16 2014-11-04 휴먼 게놈 사이언시즈, 인코포레이티드 면역특이적으로 ＢＬｙＳ에 결합하는 항체
AU2001288260A1 (en) * 2000-08-15 2002-03-13 Human Genome Sciences, Inc. Neutrokine-alpha and neutrokine-alpha splice variant
US20030091565A1 (en) 2000-08-18 2003-05-15 Beltzer James P. Binding polypeptides and methods based thereon
UA83458C2 (uk) 2000-09-18 2008-07-25 Байоджен Айдек Ма Інк. Виділений поліпептид baff-r (рецептор фактора активації в-клітин сімейства tnf)
EP2292655B1 (fr) 2001-05-11 2012-03-14 Amgen SF, LLC Peptides et molécules associées qui sont liées à tall-1
PT1436003E (pt) 2001-05-24 2010-03-12 Zymogenetics Inc Proteínas de fusão imunoglobulina taci
AR035119A1 (es) 2001-08-16 2004-04-14 Lilly Co Eli Anticuerpos humanos antagonistas anti-htnfsf13b
CA2520097C (fr) 2003-03-28 2014-10-07 Biogen Idec Ma Inc. Recepteurs baff tronques
JP2007526220A (ja) 2003-06-05 2007-09-13 ジェネンテック・インコーポレーテッド Ｂ細胞疾患の併用療法
EP1709072A1 (fr) * 2004-01-29 2006-10-11 Genentech, Inc. Variants du domaine extracellulaire de bcma et utilisations de ceux-ci
EP1812060A2 (fr) 2004-10-05 2007-08-01 Genentech, Inc. Methode de traitement de l'angeite
CA2583900A1 (fr) 2004-10-13 2006-04-27 The Washington University Utilisation de baff dans le traitement du sepsis
AU2005318086B2 (en) 2004-12-23 2011-07-07 Merck Serono Sa BCMA polypeptides and uses thereof
EP1922079A2 (fr) 2005-08-09 2008-05-21 ZymoGenetics, Inc. Procedes pour le traitement et la prevention de proliferation cellulaire anormale par le biais de molecules de fusion taci
KR20080056714A (ko) 2005-08-09 2008-06-23 지모제넥틱스, 인코포레이티드 ＴＡＣＩ―Ｉｇ 융합 분자를 사용하여 Ｂ―세포 악성종양을치료하는 방법
US9168286B2 (en) 2005-10-13 2015-10-27 Human Genome Sciences, Inc. Methods and compositions for use in treatment of patients with autoantibody positive disease
MY149159A (en) 2005-11-15 2013-07-31 Hoffmann La Roche Method for treating joint damage
JP6088723B2 (ja) 2005-11-23 2017-03-01 ジェネンテック， インコーポレイテッド Ｂ細胞アッセイに関する組成物及び方法。
WO2007123765A2 (fr) 2006-03-31 2007-11-01 Human Genome Sciences Inc. NEUTROKINE-ALPHA et variant d'epissage de la neutrokine-alpha
CN101489573B (zh) 2006-05-15 2013-05-22 阿雷斯贸易股份有限公司 用TACI-Ig融合分子治疗自身免疫疾病的方法
WO2010075249A2 (fr) 2008-12-22 2010-07-01 Genentech, Inc. Méthode de traitement de la polyarthrite rhumatoïde avec des antagonistes de cellules b
MX353186B (es) 2009-09-03 2018-01-05 Genentech Inc Metodos para el tratamiento, diagnosis y monitoreo de artritis reumatoide.
EP2680884B1 (fr) 2011-02-28 2018-01-17 F. Hoffmann-La Roche AG Marqueurs biologiques et procédés de prédiction de réponse à des antagonistes de lymphocytes b
JOP20140087B1 (ar) 2013-03-13 2021-08-17 Amgen Inc بروتينات مخصصة ل baff و b7rp1 وإستخداماتها
US9458246B2 (en) 2013-03-13 2016-10-04 Amgen Inc. Proteins specific for BAFF and B7RP1

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998018921A1 (fr) * 1996-10-25 1998-05-07 Human Genome Sciences, Inc. Neutrokine alpha

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998018921A1 (fr) * 1996-10-25 1998-05-07 Human Genome Sciences, Inc. Neutrokine alpha

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
EMBL DATABASE; EMEST6:HS307C08B; ACCESSION-NO.: D79690, 7 February 1996 (1996-02-07), XP002073749 *
EMBL DATABASE; EMEST8:HS88288; ACCESSION-NO.: R16882, 22 April 1995 (1995-04-22), XP002073748 *

Also Published As

Publication number Publication date
AU5705898A (en) 1998-07-15
WO1998027114A2 (fr) 1998-06-25

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