WO1998032858A3 - Chemokines de mammiferes, recepteurs, reactifs, et modes d'utilisation - Google Patents

Chemokines de mammiferes, recepteurs, reactifs, et modes d'utilisation Download PDF

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Publication number
WO1998032858A3
WO1998032858A3 PCT/US1998/000902 US9800902W WO9832858A3 WO 1998032858 A3 WO1998032858 A3 WO 1998032858A3 US 9800902 W US9800902 W US 9800902W WO 9832858 A3 WO9832858 A3 WO 9832858A3
Authority
WO
WIPO (PCT)
Prior art keywords
reagents
receptors
chemokines
mammalian chemokines
mammalian
Prior art date
Application number
PCT/US1998/000902
Other languages
English (en)
Other versions
WO1998032858A2 (fr
Inventor
Jeanine D Mattson
Hortensia Soto-Trejo
Joseph A Hedrick
Daniel M Gorman
Albert Zlotnik
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Priority to AU61326/98A priority Critical patent/AU6132698A/en
Publication of WO1998032858A2 publication Critical patent/WO1998032858A2/fr
Publication of WO1998032858A3 publication Critical patent/WO1998032858A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/522—Alpha-chemokines, e.g. NAP-2, ENA-78, GRO-alpha/MGSA/NAP-3, GRO-beta/MIP-2alpha, GRO-gamma/MIP-2beta, IP-10, GCP-2, MIG, PBSF, PF-4, KC
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7158—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for chemokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'invention concerne de nouvelles chémokines et 7 récepteurs transmembranaires de mammifères, des réactifs correspondants, y compris des protéines purifiées, des anticorps spécifiques, et des acides nucléiques codant lesdites chémokines ou lesdits récepteurs. L'invention concerne aussi des modes d'utilisation desdits réactifs et de trousses diagnostiques.
PCT/US1998/000902 1997-01-23 1998-01-22 Chemokines de mammiferes, recepteurs, reactifs, et modes d'utilisation WO1998032858A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU61326/98A AU6132698A (en) 1997-01-23 1998-01-22 Mammalian chemokines; receptors; reagents; uses

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3671597P 1997-01-23 1997-01-23
US60/036,715 1997-01-23

Publications (2)

Publication Number Publication Date
WO1998032858A2 WO1998032858A2 (fr) 1998-07-30
WO1998032858A3 true WO1998032858A3 (fr) 1998-11-12

Family

ID=21890201

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/000902 WO1998032858A2 (fr) 1997-01-23 1998-01-22 Chemokines de mammiferes, recepteurs, reactifs, et modes d'utilisation

Country Status (2)

Country Link
AU (1) AU6132698A (fr)
WO (1) WO1998032858A2 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7888466B2 (en) 1996-01-11 2011-02-15 Human Genome Sciences, Inc. Human G-protein chemokine receptor HSATU68
US6140064A (en) 1996-09-10 2000-10-31 Theodor-Kocher Institute Method of detecting or identifying ligands, inhibitors or promoters of CXC chemokine receptor 3
US6576445B1 (en) 1996-09-12 2003-06-10 Human Genome Sciences, Inc. Chemokine α-4
WO1999013082A1 (fr) * 1997-09-12 1999-03-18 Incyte Pharmaceuticals, Inc. Chimiokine cxc
AU1824499A (en) * 1997-12-30 1999-07-19 Chiron Corporation Human cxc chemokine ((tim-1))
JP2002502591A (ja) * 1998-02-10 2002-01-29 ミレニアム・フアーマシユーチカルズ・インコーポレーテツド ネオカインタンパク質および核酸分子ならびにそのための用途
US6573095B1 (en) 1998-04-29 2003-06-03 Genesis Research & Development Corporation Limited Polynucleotides isolated from skin cells
EP1676861A3 (fr) * 1998-10-13 2006-07-19 Arena Pharmaceuticals, Inc. Récepteurs non-endogènes de la protéine G humaine ayant une activité constitutive
US20030229216A1 (en) 1998-10-13 2003-12-11 Ruoping Chen Constitutively activated human G protein coupled receptors
US6329159B1 (en) 1999-03-11 2001-12-11 Millennium Pharmaceuticals, Inc. Anti-GPR-9-6 antibodies and methods of identifying agents which modulate GPR-9-6 function
US6919176B2 (en) 2001-05-07 2005-07-19 Amgen Inc. Polypeptides and nucleic acids associated with cancer
WO2003065045A2 (fr) * 2002-02-01 2003-08-07 Bayer Healthcare Ag Diagnostic et traitement de maladies associees au recepteur gpr65

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996016979A1 (fr) * 1994-11-29 1996-06-06 Incyte Pharmaceuticals, Inc. Production et utilisation des chimiokines exprimees
WO1996022371A2 (fr) * 1995-01-19 1996-07-25 Leukosite, Inc. RECEPTEUR 3 DE CHEMOKINES C-C: CKR-3 OU Eos-L2
WO1996039520A1 (fr) * 1995-06-06 1996-12-12 Human Genome Sciences, Inc. Chemokine beta-12 humaine
WO1997000960A1 (fr) * 1995-06-23 1997-01-09 Leukosite, Inc. Nouvelle cytokine chimiotactique humaine
WO1997035010A1 (fr) * 1996-03-19 1997-09-25 Human Genome Sciences, Inc. Chimiokine alpha 2

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996016979A1 (fr) * 1994-11-29 1996-06-06 Incyte Pharmaceuticals, Inc. Production et utilisation des chimiokines exprimees
WO1996022371A2 (fr) * 1995-01-19 1996-07-25 Leukosite, Inc. RECEPTEUR 3 DE CHEMOKINES C-C: CKR-3 OU Eos-L2
WO1996039520A1 (fr) * 1995-06-06 1996-12-12 Human Genome Sciences, Inc. Chemokine beta-12 humaine
WO1997000960A1 (fr) * 1995-06-23 1997-01-09 Leukosite, Inc. Nouvelle cytokine chimiotactique humaine
WO1997035010A1 (fr) * 1996-03-19 1997-09-25 Human Genome Sciences, Inc. Chimiokine alpha 2

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
COMBADIERE C ET AL: "CLONING AND FUNCTIONAL EXPRESSION OF CC CKR5, A HUMAN MONOCYTE CC CHEMOKINE RECEPTOR SELECTIVE FOR MIP-1ALPHA, MIP-1BETA, AND RANTES", JOURNAL OF LEUKOCYTE BIOLOGY, vol. 60, no. 1, July 1996 (1996-07-01), pages 147 - 152, XP002055732 *
J.A. HEDRICK ET AL: "Characterization of a novel CC chemokine, HCC-4, whose expression is increased by interleukin-10", BLOOD, vol. 91, no. 11, 1 June 1998 (1998-06-01), pages 4242 - 4247, XP002076800 *
M.R. SANDHYA ET AL: "Characterization of beta-R1, a gene that is selectively induced by Interferon beta (IFN-beta) compared with IFN-alpha", JOURNAL OF BIOLOGICAL CHEMISTRY., vol. 271, no. 37, 13 September 1996 (1996-09-13), MD US, pages 22878 - 22884, XP002076799 *
SCHALL T J ET AL: "CHEMOKINES, LEUKOCYTE TRAFFICKING, AND INFLAMMATION", CURRENT OPINION IN IMMUNOLOGY, vol. 6, no. 6, December 1994 (1994-12-01), pages 865 - 873, XP002048194 *

Also Published As

Publication number Publication date
AU6132698A (en) 1998-08-18
WO1998032858A2 (fr) 1998-07-30

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