WO1998025140A1 - Appareil d'analyse de liquides - Google Patents

Appareil d'analyse de liquides Download PDF

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Publication number
WO1998025140A1
WO1998025140A1 PCT/GB1997/003325 GB9703325W WO9825140A1 WO 1998025140 A1 WO1998025140 A1 WO 1998025140A1 GB 9703325 W GB9703325 W GB 9703325W WO 9825140 A1 WO9825140 A1 WO 9825140A1
Authority
WO
WIPO (PCT)
Prior art keywords
reaction chamber
chambers
reaction
disc
reaction chambers
Prior art date
Application number
PCT/GB1997/003325
Other languages
English (en)
Inventor
Sean Keeping
Dieter Binz
Albrecht Vogel
Brith Claesson
Hubert Brandle
Original Assignee
Abb Kent-Taylor Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abb Kent-Taylor Limited filed Critical Abb Kent-Taylor Limited
Priority to AU52313/98A priority Critical patent/AU5231398A/en
Publication of WO1998025140A1 publication Critical patent/WO1998025140A1/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/18—Water
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/18—Water
    • G01N33/1806—Biological oxygen demand [BOD] or chemical oxygen demand [COD]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00009—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with a sample supporting tape, e.g. with absorbent zones
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/021—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a flexible chain, e.g. "cartridge belt", conveyor for reaction cells or cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/18—Water
    • G01N33/186—Water using one or more living organisms, e.g. a fish
    • G01N33/1866—Water using one or more living organisms, e.g. a fish using microorganisms

Definitions

  • This invention relates to apparatus for the analysis of liquid media, in particular environmentally sensitive media such as, treated and untreated sewage and river water.
  • the invention particularly relates to such apparatus which is designed to measure a plurality of parameters, such as for example measuring a number of different features of the chemical composition.
  • Devices are already known for determining the biological oxygen demand, in which the oxygen consumption of the water sample is measured. These methods may be subdivided into laboratory methods and on-line measuring methods. The laboratory methods are standardized and described in DIN 38409 Part 51 . A typical procedure is a so-called dilution method with which the content of biological degradable substances in the water sample is determined. In the laboratory this test can take five days to complete.
  • Another technique is based upon use of a fermentation calorimeter, which measures the heat production of metabolic processes.
  • the heat product of the fermentation material is compensated for by appropriate cooling.
  • the cooling rate determined is proportional to the metabolic heat produced and hence is also proportional to the metabolic activity of the biomass.
  • the cost outlay on apparatus is high, and corresponding devices are too expensive for use as a process measuring device.
  • enzyme thermistors which measure the heat which is produced when an immobilized layer of enzymes reacts with an organic substance. This is measured, for example, by means of two absolute temperature sensors that are located in the feed or discharge lines of the reaction vessel having the immobilized enzymes. In so-called “flow systems” using this method, the sample under test flows through an enzyme column and, the temperature is measured determined at the end of the column. An uncoated column is used as reference. The difference between the signals from the two temperature sensors is a measure of the reaction heat.
  • One object of the present invention is to provide apparatus for analysing liquids in which the replacement and storage of the biocomponents is achieved in a manner which avoids problems associated with known systems, is simple to operate, and in which, in addition, can allow bioreagents to be stored for a longer period than hitherto.
  • apparatus for analysing liquids comprising at least one reaction chamber to which the liquid to be analysed, and optionally additional liquids required for carrying out the analysis may be fed, characterized in that:
  • the reaction chamber or chambers contains or contain at least one biocomponent and/or at least one reagent, and is arranged on a movable carrier which allows the reaction chamber or chambers to be moved to one or more selected locations at which one or more analysis operations are to be carried out, and
  • reaction chambers are arranged at spaced locations on the carrier, whereby in use, the reaction chambers may be moved sequentially to one or more selected locations at which one or more analysis operations are to be carried out.
  • reaction chambers may advantageously be arranged in sets at spaced locations on the carrier, whereby in use, the reaction chambers of individual sets may be moved so as to arrive simultaneously to associated selected locations at which one or more analysis operations are to be carried.
  • a plurality of sets of said reaction chambers are arranged at spaced locations on the carrier, whereby in use, the reaction chambers of the individual sets may be moved sequentially to the selected locations at which one or more analysis operations are to be carried out.
  • the movable carrier comprises a rotatably mounted disc and in this case the plurality of said reaction chambers may be arranged in sets which arranged at spaced locations which on the disc, whereby on rotation of the disc, the reaction chambers of individual sets may be moved so as to arrive simultaneously to associated selected locations at which one or mote analysis operations are to be carried.
  • the reaction chambers in each set may be arranged at spaced locations which are arranged radially on the disc for example in an arrangement in which:
  • the disc is provided with a plurality of reaction chambers arranged at defined spacing from one another in a row which is arranged in a radial direction, and
  • the movable carrier comprises a belt for example a belt which is arranged to be wound up onto reels.
  • the reaction chambers may be arranged in sets which arranged at spaced locations extending transversely across the belt, whereby on movement of the belt, the reaction chambers of individual sets may be moved so as to arrive simultaneously to associated selected locations at which one or more analysis operations are to be carried.
  • each reaction chamber is arranged in a borehole running perpendicularly to the surface of the disc, which bore hole passes completely through the disc,
  • each reaction chamber is arranged in a plane with the top
  • each reaction chamber is arranged in a plane with the bottom, of the disc, and
  • each reaction chamber is sealed at least at the top and the bottom by a transparent polymer film.
  • each reaction chamber has the shape of a rectangular solid, is integrated into a rectangular recess of the carrier and is delimited on all sides by a transparent film, and in that the top and bottom of each reaction chamber lie in a plane with the top and the bottom respectively of the carrier.
  • At least one sensor be arranged at the bottom of each reaction chamber.
  • each hollow needle is connected to a flexible and transparent feedline into which at least one pump is integrated, in that the feedlines can be connected to storage vessels for reagents and buffer solutions and to the feedline for the liquid under test, and (E) in that a sensor built into the distributor unit is arranged upstream of each feedline.
  • Apparatus may incorporate a measurement and evaluation unit which includes a process computer for controlling movement of the carrier, for controlling a distributor unit, and for storing and evaluating of the measurement signals from associated sensors.
  • Fig. 1 shows an apparatus according to the invention
  • Fig.2 shows a variant of the apparatus shown in Fig. 1 .
  • the apparatus 1 shown in Fig. 1 has a disc 2 containing reaction chambers 6, 7, 8, 9, a distributor unit 4, and a measurement and evaluation unit 5.
  • Sufficient reaction chambers 6, 7, 8, 9 are provided on the disc 2 used here for analyses to be carried out for at least three months.
  • the reaction chambers 6 are provided for determining the biological oxygen demand of a liquid 1 00 under test.
  • bacteria (not shown here) are disposed within each of the reaction chambers 6. These bacteria are chosen so as to be able to oxidize organic substances which are present in the liquid 100.
  • each reaction chamber 6 contains bacteria of the species Rhodococcus erytropilis and Issatchenkia orientalis.
  • the liquid 1 00 is analysed in the reaction chambers 6, 7 and 8 for its content of ammonium, nitrate and phosphate.
  • each reaction chamber 6, 7 and 8 contains at least one enzyme in the form of nitrate reductase, glutamate dehydrogenase or pyruvate oxidase.
  • the reaction chambers 6, 7 and 8 can alternatively also contain bacteria or those enzymes which can determine the content of glucose, fructose and lactose in the liquid 1 00.
  • reaction chambers 6, 7, 8, 9 are provided on each disc 2.
  • Four reaction chambers 6, 7, 8, 9, in each case, are arranged radially in a row at a defined distance from one another. Each of these rows has a defined distance from each of the two adjacent rows.
  • Each reaction chamber 6, 7, 8, 9 is arranged in a borehole 1 0 which passes through the disc 2 vertically between its top 2S and its bottom 2U.
  • Disc 2 itself thus serves as a lateral delimitation of each of the reaction chambers 6, 7, 8, 9. For this reason, it is made of a material which does not react with either enzymes or reagents and which is not decomposed by bacteria.
  • reaction chambers 6, 7, 8, 9 are such that they align in a plane with the top 2S and the bottom 2U of the disc 2. All off the reaction chambers 6, 7, 8, 9 are sealed at the top and the bottom with transparent polymer films.
  • the disc 2 is arranged between the distributor unit 4 and the measurement and evaluation unit 5 in such a manner that the surface 2S of the disc is in a horizontal plane and can still just be rotated between the two modules 4 and 5.
  • the disc 2 is mounted on a vertical axle 2C which can be rotated to move the disc 2.
  • the distributer unit 4 has a feedline 21 for the waste water 100.
  • the waste water 1 00 is distributed in the distributor unit 4 to feedlines 22, 23, 24 and 25.
  • the feedlines 22, 23, 24 and 25 are made of a flexible and transparent material.
  • a pump 32, 33, 34, 35 is additionally integrated into each feedline 22, 23, 24 and 25.
  • each feedline 22, 23, 24 and 25 is connected to a hollow needle 42, 43, 44, 45.
  • These hollow needles 42, 43, 44, 45 are positioned in such a way that their points 42S, 43S, 44S, 45S are orientated vertically and one of each of the points 42S, 43S, 44S, 45S is directed directly towards one of the reaction chambers 6, 7, 8, 9 positioned below it.
  • a hole (not shown here) is provided on each point 42S, 43S, 44S, 45S.
  • the hollow needles 42, 43, 44, 45 are connected to an apparatus 50, by means of which they can be moved .out of the distributor unit 4, individually or all together, in such a manner that the points 42S, 43S, 44S, 45S are pushed through the films, which seal the reaction chambers 6, 7, 8, 9, into the interior of the reaction chambers 6, 7, 8, 9.
  • the feedlines 22, 23, 24 and 25 are made of a flexible material, so that they can be extended slightly on transporting the hollow needles 42, 43, 44, 45 out of the distributor unit 4.
  • a predetermined (presettable) amount of the liquid 100 under test can be charged into each reaction chamber 6, 7, 8, 9 via the holes in the points 42S, 43S, 44S, 45S.
  • liquids in the form of reagents or buffer solutions which are present in storage chambers 62, 63, 64, 65 of the distributor unit 4 and are likewise distributed to the feedlines 22, 23, 24 and 25.
  • the amount of liquid which needs to be charged into each reaction chamber 6, 7, 8, 9, may be controlled via the pumps 32, 33, 34 and 35.
  • sensors 72, 73, 74, 75 are installed in such a way that, with their use the contents in the transparent feedlines 22, 23, 24, 25 can be determined.
  • the oxygen content in the liquid 1 00 under test is determined prior to being charged into the reaction chamber 6.
  • the sensors 73, 74, and 75 the amounts of reagents which are charged into the reaction chambers 7, 8, 9 are determined.
  • the sensors 92, 93, 94 and 95 which belong to the measuring and evaluation unit 5, the reaction proceeding in the reaction chambers 6, 7, 8, 9 are recorded.
  • the sensor 92 determines the amount of oxygen which still remains in the reaction chamber 6 after the organic substances present in the liquid have been converted into biomass and heat by the bacteria.
  • the biological oxygen demand of the liquid under test is determined from the amount of oxygen which was consumed in the reaction.
  • the measurement signals of the two sensors 72 and 92 are fed to a process computer 80, which is built into the measurement and evaluation unit 5.
  • the sensors 72, 73, 74, 75, 92, 93, 94 and 95 are connected to the process computer 80 via the signal leads 81 for evaluation of their measurement signals.
  • the drive apparatus 50 and pumps 32, 33, 34 and 35 are also connected to the process computer 80 via the signal leads 81 .
  • the process computer 80 also actuates a drive apparatus (not shown here) which is integrated into the axle 2C on which the disc 2 is arranged. This drive apparatus constantly rotates the disc 2 on by an amount sufficient for four unused reaction chambers 6, 7, 8, 9 to be positioned between the distributor unit 4 and the measurement and evaluation unit 5 for one analysis.
  • the disc 2 is exhausted and is removed.
  • the distributor unit 4 is elevated slightly and the old disc 2 is replaced by a new disc 2.
  • Fig.2 shows a variant of the apparatus 1 shown in Fig. 1 .
  • the two illustrative examples are essentially identical in construction. The same components are therefore furnished with the same reference numbers. The difference is merely that the disc 2 is replaced by a belt 3. This belt 3 is unrolled from a first reel 3A and wound up onto a second reel 3B. In the second reel 3B, a drive apparatus (not shown here) is installed, which is actuated by the process computer 80. The process computer 80 is therefore connected to the drive apparatus (not shown here) via a signal lead 82.
  • the belt 3 is always moved on by an amount such that, in this case also, four unused reaction chambers 6, 7, 8, 9 are always arranged between the distributor unit 4 and the measurement and evaluation unit 5.
  • Four reaction chambers 6, 7, 8, 9 are always arranged at a defined spacing on the belt 3 in rows which run perpendicularly to the longitudinal axis of the belt 3.
  • the reaction chambers 6, 7, 8, 9 are rectangular solids. They are integrated into rectangular recesses 1 1 with which the belt 3 is provided.
  • the reaction chambers 6, 7, 8, 9 have a very low height, so that Jheir tops and bottoms lie in a plane together with the top 3S and bottom 3U of the belt 3, when this is made of an appropriately thick material.
  • the belt 3 can be made of a cellulosic material.
  • the reaction chambers 6, 7, 8, 9 are bounded on all sides by a transparent film (not shown here) made of a polymer.
  • the liquid 100 is analysed in the illustrative example described here in the same manner as explained in the description to Fig.1 .
  • a heating device (not shown here) can be installed, and, for the reagents, a cooling device (not shown here) can be installed.
  • the chambers 6, 7, 8, 9 of the disc 2 and of the belt 3 can also be used solely as pure storage vessels for bacteria and enzymes.
  • a measurement and evaluation unit 5 is used (not shown here), in which a reaction chamber is installed immediately upstream of each sensor 92, 93, 94 and 95.
  • the liquid 1 00 under test is fed to these reaction chambers via the hollow needles 42, 43, 44 and 45, in this case also.
  • the hollow needles 42, 43, 44 and 45 are transported in this case out of the distributor unit 4 to the extent that they completely pierce the chambers 6, 7, 8, 9 on the disc 2 or on the belt 3. This means that the bacteria and enzymes present in the chambers 6, 7, 8 and 9 flow downwards into the reaction chambers upstream of the sensors 92, 93, 94 and 95 and are there mixed with the waste water which flows out of the holes in the hollow needles 42, 43, 44, 45.

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

L'invention se rapporte à un appareil d'analyse de liquides (100). A cet effet, l'appareil (1) est doté d'au moins une chambre de réaction (6, 7, 8, 9) dans laquelle sont introduits le liquide (100) à tester et les liquides destinés à l'analyse. Les appareils de ce type s'utilisent, par exemple, dans des stations d'épuration pour analyser les eaux usées (100). Ces appareils (1) peuvent fonctionner sur de très longues périodes sans qu'il soit nécessaire de les entretenir. La seule difficulté qu'ils posent est le stockage des bactéries et des enzymes nécessaires à l'analyse. Ces biocomposants ont une durée de vie réduite et doivent donc être remplacés fréquemment. Afin de faciliter le remplacement de ces biocomposants, l'invention prévoit des chambres de réaction (6, 7, 8, 9), qui peuvent chacune être utilisées en vue d'effectuer une seule analyse. Ces chambres renferment au moins un biocomposant et sont placées sur un composant (2, 3) interchangeable, monté mobile et construit sous forme d'un disque (2) ou d'une courroie (3).
PCT/GB1997/003325 1996-12-02 1997-12-02 Appareil d'analyse de liquides WO1998025140A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU52313/98A AU5231398A (en) 1996-12-02 1997-12-02 Apparatus for the analysis of liquid

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19649811.2 1996-12-02
DE1996149811 DE19649811B4 (de) 1996-12-02 1996-12-02 Vorrichtung zur Analyse von Flüssigkeiten

Publications (1)

Publication Number Publication Date
WO1998025140A1 true WO1998025140A1 (fr) 1998-06-11

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ID=7813312

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1997/003325 WO1998025140A1 (fr) 1996-12-02 1997-12-02 Appareil d'analyse de liquides

Country Status (3)

Country Link
AU (1) AU5231398A (fr)
DE (1) DE19649811B4 (fr)
WO (1) WO1998025140A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003029845A3 (fr) * 2001-10-01 2003-05-15 Vision Biosystems Ltd Traitement histologique d'echantillons tissulaires
FR2835615A1 (fr) * 2002-02-07 2003-08-08 Antonios Vekris Dispositif d'analyse d'une molecule au moyen d'un fluide venant en contact avec un support portant une molecule
FR2835614A1 (fr) * 2002-02-07 2003-08-08 Antonios Vekris Dispositif d'analyse d'une macromolecule au moyen d'un fluide venant en contact avec un support portant la macromolecule
US8554372B2 (en) 2003-09-29 2013-10-08 Leica Biosystems Melbourne Pty Ltd System and method for histological tissue specimen processing

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2836720A1 (fr) * 2002-03-01 2003-09-05 Antonios Vekris Dispositif d'analyse d'une molecule comprenant un support pour des molecules et une chambre de reception d'une molecule
AU2002344996A1 (en) * 2002-05-31 2003-12-19 Abb Patent Gmbh Analysis device for monitoring the quality of a gaseous substance or substance mixture, particularly air
CA2552358A1 (fr) * 2002-12-31 2004-07-15 Telaura Inc. Systeme et procede pour detecter en temps reel et surveiller a distance des agents pathogenes
AT503410B1 (de) * 2006-03-21 2008-03-15 Helmut Dr Pfuetzner Vorrichtung zur überwachnung mikrobiologischer wasserqualität
FR2977675A1 (fr) * 2011-07-08 2013-01-11 Stago Diagnostica Dispositif de stockage de cuvettes de reaction
AT513085B1 (de) * 2012-07-04 2016-01-15 Vwm Gmbh Verfahren zur Untersuchung einer Probe

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Publication number Priority date Publication date Assignee Title
GB1192009A (en) * 1966-09-14 1970-05-13 Atomic Energy Authority Uk Improvements in or relating to Automatic Chemical Processing Apparatus
EP0072284A2 (fr) * 1981-08-05 1983-02-16 LE MATERIEL BIOMEDICAL Société à Responsabilité Limitée dite: Support de réaction à récipients multiples pour tests de doses liquides
DE3230901A1 (de) * 1981-08-19 1983-03-10 Olympus Optical Co., Ltd., Tokyo Analysegeraet fuer chemische analysen
JPS608752A (ja) * 1983-06-29 1985-01-17 Shimadzu Corp 自動分析装置
US4697462A (en) * 1986-05-27 1987-10-06 California Institute Of Technology Active cloudwater collector
FR2618553A1 (fr) * 1987-07-24 1989-01-27 Materiel Biomedical Support de reaction a recipients multiples, et systeme de tests comportant ledit support
US4883642A (en) * 1984-06-05 1989-11-28 Universite Paris-Nord Means to automatically hold, process, store and analyze biological samples
WO1990015332A1 (fr) * 1989-06-08 1990-12-13 University Of Wales College Of Medicine Procedes et appareil de prelevement et d'analyse
US5149501A (en) * 1990-01-29 1992-09-22 Cirrus Diagnostics, Inc. Multichambered container and instrument for performing diagnostic tests
DE4314981A1 (de) * 1992-05-15 1993-12-02 Lange Gmbh Dr Bruno Vorrichtung und Verfahren zur Schnellbestimmung des biochemischen Sauerstoffbedarfs (BSB)
DE4332163A1 (de) * 1993-09-22 1995-03-23 Kolibri Umweltanalytik Und On Verfahren und Gerät zur Schadstoffanalyse von Gewässerproben

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1192009A (en) * 1966-09-14 1970-05-13 Atomic Energy Authority Uk Improvements in or relating to Automatic Chemical Processing Apparatus
EP0072284A2 (fr) * 1981-08-05 1983-02-16 LE MATERIEL BIOMEDICAL Société à Responsabilité Limitée dite: Support de réaction à récipients multiples pour tests de doses liquides
DE3230901A1 (de) * 1981-08-19 1983-03-10 Olympus Optical Co., Ltd., Tokyo Analysegeraet fuer chemische analysen
JPS608752A (ja) * 1983-06-29 1985-01-17 Shimadzu Corp 自動分析装置
US4883642A (en) * 1984-06-05 1989-11-28 Universite Paris-Nord Means to automatically hold, process, store and analyze biological samples
US4697462A (en) * 1986-05-27 1987-10-06 California Institute Of Technology Active cloudwater collector
FR2618553A1 (fr) * 1987-07-24 1989-01-27 Materiel Biomedical Support de reaction a recipients multiples, et systeme de tests comportant ledit support
WO1990015332A1 (fr) * 1989-06-08 1990-12-13 University Of Wales College Of Medicine Procedes et appareil de prelevement et d'analyse
US5149501A (en) * 1990-01-29 1992-09-22 Cirrus Diagnostics, Inc. Multichambered container and instrument for performing diagnostic tests
DE4314981A1 (de) * 1992-05-15 1993-12-02 Lange Gmbh Dr Bruno Vorrichtung und Verfahren zur Schnellbestimmung des biochemischen Sauerstoffbedarfs (BSB)
DE4332163A1 (de) * 1993-09-22 1995-03-23 Kolibri Umweltanalytik Und On Verfahren und Gerät zur Schadstoffanalyse von Gewässerproben

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 009, no. 122 (P - 359) 28 May 1985 (1985-05-28) *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003029845A3 (fr) * 2001-10-01 2003-05-15 Vision Biosystems Ltd Traitement histologique d'echantillons tissulaires
US7371346B2 (en) 2001-10-01 2008-05-13 Leica Biosystems Melbourne Pty Ltd Histological tissue specimen treatment
US8394322B2 (en) 2001-10-01 2013-03-12 Leica Biosystems Melbourne Pty Ltd Histological tissue specimen treatment
FR2835615A1 (fr) * 2002-02-07 2003-08-08 Antonios Vekris Dispositif d'analyse d'une molecule au moyen d'un fluide venant en contact avec un support portant une molecule
FR2835614A1 (fr) * 2002-02-07 2003-08-08 Antonios Vekris Dispositif d'analyse d'une macromolecule au moyen d'un fluide venant en contact avec un support portant la macromolecule
WO2003066218A1 (fr) * 2002-02-07 2003-08-14 Antonios Vekris Dispositif d'analyse d'une molecule au moyen d'un fluide venant en contact avec un support portant une molecule
US8554372B2 (en) 2003-09-29 2013-10-08 Leica Biosystems Melbourne Pty Ltd System and method for histological tissue specimen processing

Also Published As

Publication number Publication date
DE19649811A1 (de) 1998-06-04
AU5231398A (en) 1998-06-29
DE19649811B4 (de) 2007-02-22

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