WO1998020124A3 - Proteines mediatrices du diabete et leurs utilisations therapeutiques - Google Patents

Proteines mediatrices du diabete et leurs utilisations therapeutiques

Info

Publication number
WO1998020124A3
WO1998020124A3 PCT/IB1997/001627 IB9701627W WO9820124A3 WO 1998020124 A3 WO1998020124 A3 WO 1998020124A3 IB 9701627 W IB9701627 W IB 9701627W WO 9820124 A3 WO9820124 A3 WO 9820124A3
Authority
WO
WIPO (PCT)
Prior art keywords
diabetes
mediating
therapeutic uses
mediating proteins
altering
Prior art date
Application number
PCT/IB1997/001627
Other languages
English (en)
Other versions
WO1998020124A2 (fr
Inventor
Larsen Peter Mose
Stephen J Fey
Joern Nerup
Allan E Karlsen
Christensen Ulla Bjerre
Flemming Pociot
Henrik U Andersen
Original Assignee
Larsen Peter Mose
Stephen J Fey
Joern Nerup
Allan E Karlsen
Christensen Ulla Bjerre
Flemming Pociot
Henrik U Andersen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Larsen Peter Mose, Stephen J Fey, Joern Nerup, Allan E Karlsen, Christensen Ulla Bjerre, Flemming Pociot, Henrik U Andersen filed Critical Larsen Peter Mose
Priority to CA002269646A priority Critical patent/CA2269646A1/fr
Priority to US09/297,040 priority patent/US7078375B1/en
Priority to AU54070/98A priority patent/AU5407098A/en
Priority to JP52118298A priority patent/JP2002504806A/ja
Priority to EP97947839A priority patent/EP0934409A2/fr
Publication of WO1998020124A2 publication Critical patent/WO1998020124A2/fr
Publication of WO1998020124A3 publication Critical patent/WO1998020124A3/fr
Priority to US11/488,184 priority patent/US7531323B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0325—Animal model for autoimmune diseases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2550/00—Electrophoretic profiling, e.g. for proteome analysis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Environmental Sciences (AREA)
  • Hematology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Plant Pathology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Medical Informatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Quality & Reliability (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • General Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • Cell Biology (AREA)
  • Animal Husbandry (AREA)

Abstract

L'invention concerne des protéines médiatrices du diabète, protectrices et néfastes, les polynucléotides codant pour lesdites protéines, des animaux transgéniques exprimant une protéine médiatrice du diabète, des méthodes de criblage de médicaments qui permettent d'identifier un composé test capable de modifier l'expression desdites protéines, ainsi que des méthodes qui permettent de prévenir ou d'améliorer le diabète en administrant un composé capable de modifier l'expression d'une protéine médiatrice du diabète.
PCT/IB1997/001627 1996-10-25 1997-10-24 Proteines mediatrices du diabete et leurs utilisations therapeutiques WO1998020124A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA002269646A CA2269646A1 (fr) 1996-10-25 1997-10-24 Proteines mediatrices du diabete et leurs utilisations therapeutiques
US09/297,040 US7078375B1 (en) 1996-10-25 1997-10-24 Diabetes-mediating proteins and therapeutic uses thereof
AU54070/98A AU5407098A (en) 1996-10-25 1997-10-24 Diabetes-mediating proteins and therapeutic uses thereof
JP52118298A JP2002504806A (ja) 1996-10-25 1997-10-24 糖尿病媒介タンパク質およびその治療的使用
EP97947839A EP0934409A2 (fr) 1996-10-25 1997-10-24 Proteines mediatrices du diabete et leurs utilisations therapeutiques
US11/488,184 US7531323B2 (en) 1996-10-25 2006-07-18 Diabetes-mediating proteins and therapeutic uses thereof

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US2932496P 1996-10-25 1996-10-25
US60/029,324 1996-10-25
US3018696P 1996-11-05 1996-11-05
US3008896P 1996-11-05 1996-11-05
US60/030,186 1996-11-05
US60/030,088 1996-11-05
US89709897A 1997-07-18 1997-07-18
US08/897,098 1997-07-18

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09297040 A-371-Of-International 1997-10-24
US11/488,184 Continuation US7531323B2 (en) 1996-10-25 2006-07-18 Diabetes-mediating proteins and therapeutic uses thereof

Publications (2)

Publication Number Publication Date
WO1998020124A2 WO1998020124A2 (fr) 1998-05-14
WO1998020124A3 true WO1998020124A3 (fr) 1998-10-08

Family

ID=27487746

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB1997/001627 WO1998020124A2 (fr) 1996-10-25 1997-10-24 Proteines mediatrices du diabete et leurs utilisations therapeutiques

Country Status (5)

Country Link
EP (1) EP0934409A2 (fr)
JP (2) JP2002504806A (fr)
AU (1) AU5407098A (fr)
CA (1) CA2269646A1 (fr)
WO (1) WO1998020124A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000024422A1 (fr) * 1998-10-27 2000-05-04 Suntory Limited Procede de production de regulateurs glycolytiques du metabolisme
JP2002534088A (ja) * 1999-01-07 2002-10-15 インサイト・ファーマスーティカルズ・インコーポレイテッド インスリン合成遺伝子
AU773329B2 (en) * 1999-05-14 2004-05-20 Proteomedica Ab Materials and methods relating to disease diagnosis
EP1402257B1 (fr) * 2001-05-29 2009-01-21 Pride Proteomics A/S Proteines utiles dans l'analyse proteomique du diabete
EP1430155A2 (fr) * 2001-09-05 2004-06-23 Pride Proteomics A/S Proteines impliquees dans le diabete de type 2
EP2071338A3 (fr) * 2002-03-20 2009-07-22 Pride Proteomics A/S Protéines liées au diabète humain

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
31st annual meeting of the european association for the study of diabetes, STOCKHOLM, SWEDEN, September 12-16 1995 *
ANDERSEN, H.U. ET AL.: "Two-dimensional gel electrophoresis of rat islet proteins. Interleukin 1Beta-induced changes in protein expression are reduced by L-arginine depletion and nicotinamide", DIABETES, vol. 44, no. 4, April 1995 (1995-04-01), pages 400 - 407, XP002062766 *
CHRISTENSEN, U.B. ET AL.: "Protein expression at diabetes onset in BB-rats differs from that seen during islet allograft rejection", DIABETOLOGIA, vol. 38, no. suppl. 1, 1995, pages A85, XP002062765 *
Fifth annual conference of the international cytokine society, Lake Tahoe, USA. November 9-13 1997, *
KARLSEN, A.E. ET AL.: "Identification and characterization of proteins involved in cytokine mediated beta-cell destruction and insulin-dependent diabetes mellitus", CYTOKINE, vol. 9, no. 11, November 1997 (1997-11-01), pages 912, XP002062768 *
POCIOT, F. ET AL.: "A comprehensive approach to identifying new susceptibility genes to insulin-dependent diabetes mellitus: combining proteome and genome analysis", CYTOKINE, vol. 9, no. 11, November 1997 (1997-11-01), pages 899, XP002062767 *

Also Published As

Publication number Publication date
JP2002504806A (ja) 2002-02-12
CA2269646A1 (fr) 1998-05-14
EP0934409A2 (fr) 1999-08-11
WO1998020124A2 (fr) 1998-05-14
AU5407098A (en) 1998-05-29
JP2008195721A (ja) 2008-08-28

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