JP2002504806A - 糖尿病媒介タンパク質およびその治療的使用 - Google Patents

糖尿病媒介タンパク質およびその治療的使用

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Publication number
JP2002504806A
JP2002504806A JP52118298A JP52118298A JP2002504806A JP 2002504806 A JP2002504806 A JP 2002504806A JP 52118298 A JP52118298 A JP 52118298A JP 52118298 A JP52118298 A JP 52118298A JP 2002504806 A JP2002504806 A JP 2002504806A
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Prior art keywords
diabetes
protein
proteins
expression
mediating
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JP52118298A
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English (en)
Japanese (ja)
Other versions
JP2002504806A5 (fr
Inventor
ラルセン,ペーテル モーゼ
ジェイ. フェイ,スティーブン
ネルプ,ジョーン
イー. カールセン,アラン
クリステンセン,ウラ ブジェリー
ポシオト,フレミング
ユー. アンダーセン,ヘンリク
Original Assignee
ラルセン,ペーテル モーゼ
ジェイ. フェイ,スティーブン
ネルプ,ジョーン
イー. カールセン,アラン
クリステンセン,ウラ ブジェリー
ポシオト,フレミング
ユー. アンダーセン,ヘンリク
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Application filed by ラルセン,ペーテル モーゼ, ジェイ. フェイ,スティーブン, ネルプ,ジョーン, イー. カールセン,アラン, クリステンセン,ウラ ブジェリー, ポシオト,フレミング, ユー. アンダーセン,ヘンリク filed Critical ラルセン,ペーテル モーゼ
Publication of JP2002504806A publication Critical patent/JP2002504806A/ja
Publication of JP2002504806A5 publication Critical patent/JP2002504806A5/ja
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027New or modified breeds of vertebrates
    • A01K67/0271Chimeric vertebrates, e.g. comprising exogenous cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4713Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00Image analysis
    • G06T7/0002Inspection of images, e.g. flaw detection
    • G06T7/0012Biomedical image inspection
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/05Animals comprising random inserted nucleic acids (transgenic)
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00Animals characterised by species
    • A01K2227/10Mammal
    • A01K2227/105Murine
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/03Animal model, e.g. for test or diseases
    • A01K2267/0306Animal model for genetic diseases
    • A01K2267/0325Animal model for autoimmune diseases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00Vector systems having a special element relevant for transcription
    • C12N2830/008Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2550/00Electrophoretic profiling, e.g. for proteome analysis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Environmental Sciences (AREA)
  • Hematology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Plant Pathology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Medical Informatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Quality & Reliability (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • General Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • Cell Biology (AREA)
  • Animal Husbandry (AREA)
JP52118298A 1996-10-25 1997-10-24 糖尿病媒介タンパク質およびその治療的使用 Withdrawn JP2002504806A (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US2932496P 1996-10-25 1996-10-25
US60/029,324 1996-10-25
US3018696P 1996-11-05 1996-11-05
US3008896P 1996-11-05 1996-11-05
US60/030,186 1996-11-05
US60/030,088 1996-11-05
US89709897A 1997-07-18 1997-07-18
US08/897,098 1997-07-18
PCT/IB1997/001627 WO1998020124A2 (fr) 1996-10-25 1997-10-24 Proteines mediatrices du diabete et leurs utilisations therapeutiques

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2008040600A Division JP2008195721A (ja) 1996-10-25 2008-02-21 糖尿病媒介タンパク質およびその治療的使用

Publications (2)

Publication Number Publication Date
JP2002504806A true JP2002504806A (ja) 2002-02-12
JP2002504806A5 JP2002504806A5 (fr) 2005-07-14

Family

ID=27487746

Family Applications (2)

Application Number Title Priority Date Filing Date
JP52118298A Withdrawn JP2002504806A (ja) 1996-10-25 1997-10-24 糖尿病媒介タンパク質およびその治療的使用
JP2008040600A Pending JP2008195721A (ja) 1996-10-25 2008-02-21 糖尿病媒介タンパク質およびその治療的使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2008040600A Pending JP2008195721A (ja) 1996-10-25 2008-02-21 糖尿病媒介タンパク質およびその治療的使用

Country Status (5)

Country Link
EP (1) EP0934409A2 (fr)
JP (2) JP2002504806A (fr)
AU (1) AU5407098A (fr)
CA (1) CA2269646A1 (fr)
WO (1) WO1998020124A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1062954T3 (da) 1998-10-27 2007-09-10 Suntory Ltd Anvendelse af itakonsyre til regulering af det glykotiske stofskifte
WO2000040722A2 (fr) * 1999-01-07 2000-07-13 Incyte Pharmaceuticals, Inc. Genes de synthese de l'insuline
WO2000070340A2 (fr) * 1999-05-14 2000-11-23 Karolinska Innovations Ab Materiaux et procedes se rapportant au diagnostic de maladie
EP2161578A1 (fr) * 2001-05-29 2010-03-10 Pride Proteomics A/S Protéines dans l'analyse du protéome du diabète
EP1430155A2 (fr) 2001-09-05 2004-06-23 Pride Proteomics A/S Proteines impliquees dans le diabete de type 2
EP2071338A3 (fr) * 2002-03-20 2009-07-22 Pride Proteomics A/S Protéines liées au diabète humain

Also Published As

Publication number Publication date
WO1998020124A3 (fr) 1998-10-08
EP0934409A2 (fr) 1999-08-11
AU5407098A (en) 1998-05-29
CA2269646A1 (fr) 1998-05-14
JP2008195721A (ja) 2008-08-28
WO1998020124A2 (fr) 1998-05-14

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