WO2002097441A3 - Proteines de mammifere mediatrices du diabete - Google Patents

Proteines de mammifere mediatrices du diabete Download PDF

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Publication number
WO2002097441A3
WO2002097441A3 PCT/DK2002/000368 DK0200368W WO02097441A3 WO 2002097441 A3 WO2002097441 A3 WO 2002097441A3 DK 0200368 W DK0200368 W DK 0200368W WO 02097441 A3 WO02097441 A3 WO 02097441A3
Authority
WO
WIPO (PCT)
Prior art keywords
diabetes
mediating
mediating proteins
proteins
mammalian
Prior art date
Application number
PCT/DK2002/000368
Other languages
English (en)
Other versions
WO2002097441A2 (fr
Inventor
Peter Mose Larsen
Stephen J Fey
Allan E Karlsen
Thomas Sparre
Joern Nerup
Original Assignee
Univ Syddansk
Peter Mose Larsen
Stephen J Fey
Allan E Karlsen
Thomas Sparre
Joern Nerup
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Syddansk, Peter Mose Larsen, Stephen J Fey, Allan E Karlsen, Thomas Sparre, Joern Nerup filed Critical Univ Syddansk
Priority to EP02742844A priority Critical patent/EP1421390A2/fr
Priority to AU2002344252A priority patent/AU2002344252A1/en
Publication of WO2002097441A2 publication Critical patent/WO2002097441A2/fr
Publication of WO2002097441A3 publication Critical patent/WO2002097441A3/fr
Priority to US10/960,652 priority patent/US7279274B2/en
Priority to US11/869,546 priority patent/US20080145868A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Cette invention concerne des protéines de mammifère médiatrices du diabète sécrétées et non sécrétées, y compris des protéines médiatrices du diabète protectrices et délétères, ainsi que des polynucléotides codants ces protéines, des méthodes de criblage de médicaments servant à identifier un composé de test pouvant modifier l'expression d'une protéine médiatrice du diabète, et des méthodes de prévention ou d'amélioration du diabète consistant à administrer un composé pouvant modifier l'expression d'une protéine médiatrice du diabète.
PCT/DK2002/000368 2001-05-29 2002-05-29 Proteines de mammifere mediatrices du diabete WO2002097441A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP02742844A EP1421390A2 (fr) 2001-05-29 2002-05-29 Proteines de mammifere mediatrices du diabete
AU2002344252A AU2002344252A1 (en) 2001-05-29 2002-05-29 Mammalian diabetes-mediating proteins
US10/960,652 US7279274B2 (en) 2001-05-29 2004-10-07 Method for diagnosing diabetes in a mammal
US11/869,546 US20080145868A1 (en) 2001-05-29 2007-10-09 Method for diagnosing diabetes in a mammal

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DKPA200100852 2001-05-29
DKPA200100852 2001-05-29
DKPA200200446 2002-03-22
DKPA200200446 2002-03-22

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10479530 A-371-Of-International 2002-05-29
US10/960,652 Continuation US7279274B2 (en) 2001-05-29 2004-10-07 Method for diagnosing diabetes in a mammal

Publications (2)

Publication Number Publication Date
WO2002097441A2 WO2002097441A2 (fr) 2002-12-05
WO2002097441A3 true WO2002097441A3 (fr) 2004-03-25

Family

ID=26069028

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2002/000368 WO2002097441A2 (fr) 2001-05-29 2002-05-29 Proteines de mammifere mediatrices du diabete

Country Status (3)

Country Link
EP (1) EP1421390A2 (fr)
AU (1) AU2002344252A1 (fr)
WO (1) WO2002097441A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003078456A2 (fr) * 2002-03-20 2003-09-25 Syddansk Universitet Proteines humaines mediatrices du diabete
FR2910025A1 (fr) * 2006-12-19 2008-06-20 Biomerieux Sa Procede pour le diagnostic du diabete
US20120034608A1 (en) * 2009-04-14 2012-02-09 Merck Sharp & Dohme Corp. Microrna as a biomarker of pancreatic islet beta-cell engagement

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998019271A1 (fr) * 1996-10-25 1998-05-07 Peter Mose Larsen Analyse de proteome pour caracteriser des proteines a regulation positive et negative dans des echantillons biologiques
WO2001001130A1 (fr) * 1999-06-25 2001-01-04 Proteome Sciences Plc PROCEDES ET COMPOSITIONS SE RAPPORTANT AU DYSFONCTIONS DES ILOTS PANCREATIQUES ET DES CELLULES $g(b)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2375850A1 (fr) * 1999-06-01 2000-12-07 Proteome Sciences Plc Procede et compositions lies aux troubles de la resistance a l'insuline

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998019271A1 (fr) * 1996-10-25 1998-05-07 Peter Mose Larsen Analyse de proteome pour caracteriser des proteines a regulation positive et negative dans des echantillons biologiques
WO2001001130A1 (fr) * 1999-06-25 2001-01-04 Proteome Sciences Plc PROCEDES ET COMPOSITIONS SE RAPPORTANT AU DYSFONCTIONS DES ILOTS PANCREATIQUES ET DES CELLULES $g(b)

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ANDERSEN H.U. ET AL.: "Interleukin-1beta induced changes in the protein expression of rat islets : a computerized database.", ELECTROPHORESIS, vol. 18, 1997, pages 2091 - 2103, XP002902695 *
CHRISTENSEN U.B. ET AL.: "Islet protein expression changes during diabetes development in islet syngrafts in BB-DP islet allografts.", AUTOIMMUNITY, vol. 32, 2000, pages 1 - 15, XP002902697 *
JOHN N.E. ET AL.: "Cytokine- or chemically derived nitric oxide alters the expression of proteins detected by two-dimensional gel electrophoresis in neonatal rat islets of Langerhans.", DIABETES, vol. 49, November 2000 (2000-11-01), pages 1819 - 1829, XP002236131 *
MOSE LARSEN P. ET AL.: "Proteome analysis of interleukin-1beta-induced changes in protein expression in rat islets of Langerhans.", DIABETES, vol. 50, May 2001 (2001-05-01), pages 1056 - 1063, XP002236130 *
See also references of EP1421390A2 *

Also Published As

Publication number Publication date
WO2002097441A2 (fr) 2002-12-05
EP1421390A2 (fr) 2004-05-26
AU2002344252A1 (en) 2002-12-09

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