WO2000058465A3 - Analogues polypeptidiques de flint - Google Patents

Analogues polypeptidiques de flint Download PDF

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Publication number
WO2000058465A3
WO2000058465A3 PCT/US2000/006417 US0006417W WO0058465A3 WO 2000058465 A3 WO2000058465 A3 WO 2000058465A3 US 0006417 W US0006417 W US 0006417W WO 0058465 A3 WO0058465 A3 WO 0058465A3
Authority
WO
WIPO (PCT)
Prior art keywords
flint
analogs
polypeptide analogs
flint polypeptide
polydeoxynucleotides
Prior art date
Application number
PCT/US2000/006417
Other languages
English (en)
Other versions
WO2000058465A2 (fr
Inventor
Gerald Wayne Becker
Fredric Jay Cohen
Patricia Ann Gonzalez-Dewhitt
John Edward Hale
Radmila Micanovic
Christy Michelle Newton
Timothy Wayne Noblitt
Radhakrishnan Rathmachalam
Sheng-Hung Rainbow Tschang
Derrick Ryan Witcher
Victor John Wroblewski
Original Assignee
Lilly Co Eli
Gerald Wayne Becker
Fredric Jay Cohen
Gonzalez Dewhitt Patricia Ann
John Edward Hale
Radmila Micanovic
Christy Michelle Newton
Timothy Wayne Noblitt
Radhakrishnan Rathmachalam
Tschang Sheng Hung Rainbow
Derrick Ryan Witcher
Victor John Wroblewski
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli, Gerald Wayne Becker, Fredric Jay Cohen, Gonzalez Dewhitt Patricia Ann, John Edward Hale, Radmila Micanovic, Christy Michelle Newton, Timothy Wayne Noblitt, Radhakrishnan Rathmachalam, Tschang Sheng Hung Rainbow, Derrick Ryan Witcher, Victor John Wroblewski filed Critical Lilly Co Eli
Priority to EP00916263A priority Critical patent/EP1165780A2/fr
Priority to CA002368760A priority patent/CA2368760A1/fr
Priority to US09/936,024 priority patent/US6965012B1/en
Priority to JP2000608746A priority patent/JP2002539828A/ja
Priority to AU37394/00A priority patent/AU3739400A/en
Publication of WO2000058465A2 publication Critical patent/WO2000058465A2/fr
Publication of WO2000058465A3 publication Critical patent/WO2000058465A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'invention concerne des analogues polypeptidiques de FLINT (FAS Ligand Inhibitory proteins/protéines inhibitrices de ligands FAS), des polydésoxynucléotides codant pour les analogues de FLINT et des méthodes d'utilisation de polydésoxynucléotides et d'analogues de FLINT. Les analogues de FLINT de l'invention comprennent des polypeptides possédant la séquence d'acides aminés de FLINT, modifiée au niveau d'une ou plusieurs positions par des substitutions d'acide aminé, et comprennent des fragments de celles-ci, ainsi que des fusions Fc comprenant FLINT et des analogues de FLINT.
PCT/US2000/006417 1999-03-30 2000-03-20 Analogues polypeptidiques de flint WO2000058465A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP00916263A EP1165780A2 (fr) 1999-03-30 2000-03-20 Analogues polypeptidiques de flint
CA002368760A CA2368760A1 (fr) 1999-03-30 2000-03-20 Analogues polypeptidiques de flint
US09/936,024 US6965012B1 (en) 1999-03-30 2000-03-20 Flint polypeptide analogs
JP2000608746A JP2002539828A (ja) 1999-03-30 2000-03-20 Ｆｌｉｎｔポリペプチドアナログ
AU37394/00A AU3739400A (en) 1999-03-30 2000-03-20 Flint polypeptide analogs

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US12683999P 1999-03-30 1999-03-30
US60/126,839 1999-03-30
US14007799P 1999-06-21 1999-06-21
US14015699P 1999-06-21 1999-06-21
US60/140,077 1999-06-21
US60/140,156 1999-06-21
US16056699P 1999-10-20 1999-10-20
US60/160,566 1999-10-20
US18339800P 2000-02-18 2000-02-18
US60/183,398 2000-02-18

Publications (2)

Publication Number Publication Date
WO2000058465A2 WO2000058465A2 (fr) 2000-10-05
WO2000058465A3 true WO2000058465A3 (fr) 2001-01-25

Family

ID=27537769

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/006417 WO2000058465A2 (fr) 1999-03-30 2000-03-20 Analogues polypeptidiques de flint

Country Status (5)

Country Link
EP (1) EP1165780A2 (fr)
JP (1) JP2002539828A (fr)
AU (1) AU3739400A (fr)
CA (1) CA2368760A1 (fr)
WO (1) WO2000058465A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7285267B2 (en) 1997-01-14 2007-10-23 Human Genome Sciences, Inc. Tumor necrosis factor receptors 6α & 6β
EP1007659B1 (fr) 1997-01-14 2007-06-27 Human Genome Sciences, Inc. Recepteurs 6 alpha & 6 beta du facteur de necrose tumorale
IL134578A0 (en) 1997-09-18 2001-04-30 Genentech Inc DcR3 POLYPEPTIDE, A TNFR HOMOLOG
AU7053100A (en) * 1999-09-10 2001-04-10 Eli Lilly And Company Flint analog compounds and formulations thereof
AU1189101A (en) * 1999-10-20 2001-04-30 Eli Lilly And Company Therapeutic applications of flint polypeptides
AU1915201A (en) * 1999-12-07 2001-06-18 Eli Lilly And Company Improving stability of flint through o-linked glycosylation
AU2002246967A1 (en) * 2001-02-01 2002-08-12 Eli Lilly And Company Glycoforms a fas ligand inhibitory protein analog
EP1355945A2 (fr) * 2001-02-01 2003-10-29 Eli Lilly And Company Glycoformes de flint
CA2439193A1 (fr) * 2001-02-23 2002-08-29 Hideki Matsui Inhibiteurs de caspase 3
KR100754667B1 (ko) 2005-04-08 2007-09-03 한미약품 주식회사 비펩타이드성 중합체로 개질된 면역글로불린 Ｆｃ 단편 및이를 포함하는 약제학적 조성물

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998030694A2 (fr) * 1997-01-14 1998-07-16 Human Genome Sciences, Inc. RECEPTEURS 6α ET 6β DU FACTEUR DE NECROSE TUMORALE
WO1999004001A1 (fr) * 1997-07-21 1999-01-28 Zymogenetics, Inc. Recepteur ztnfr-5 du facteur de necrose tumorale
WO1999014330A1 (fr) * 1997-09-18 1999-03-25 Genentech, Inc. HOMOLOGUE DU TNFR APPELE POLYPEPTIDE DcR3
WO2000034782A1 (fr) * 1998-12-09 2000-06-15 Eli Lilly And Company Compositions flint et leurs utilisations

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1165781B1 (fr) * 1999-03-30 2007-08-29 Eli Lilly And Company Analogues de flint resistant aux proteases

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998030694A2 (fr) * 1997-01-14 1998-07-16 Human Genome Sciences, Inc. RECEPTEURS 6α ET 6β DU FACTEUR DE NECROSE TUMORALE
WO1999004001A1 (fr) * 1997-07-21 1999-01-28 Zymogenetics, Inc. Recepteur ztnfr-5 du facteur de necrose tumorale
WO1999014330A1 (fr) * 1997-09-18 1999-03-25 Genentech, Inc. HOMOLOGUE DU TNFR APPELE POLYPEPTIDE DcR3
WO2000034782A1 (fr) * 1998-12-09 2000-06-15 Eli Lilly And Company Compositions flint et leurs utilisations

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
PITTI ET AL: "Genomic amplification of a decoy receptor for FAS ligand in lung and colon cancer", NATURE, vol. 396, 17 December 1998 (1998-12-17), pages 699 - 703, XP002139977 *
See also references of EP1165780A2 *
SHEIKH M S ET AL.: "Death and decoy receptors and p53-mediated apoptosis", LEUKEMIA, vol. 14, no. 8, August 2000 (2000-08-01), pages 1509 - 1513, XP000946082 *

Also Published As

Publication number Publication date
EP1165780A2 (fr) 2002-01-02
WO2000058465A2 (fr) 2000-10-05
JP2002539828A (ja) 2002-11-26
AU3739400A (en) 2000-10-16
CA2368760A1 (fr) 2000-10-05

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