WO1998019684A3 - Herstellung von trockenen lactulose-arzneiformen - Google Patents

Herstellung von trockenen lactulose-arzneiformen Download PDF

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Publication number
WO1998019684A3
WO1998019684A3 PCT/EP1997/006135 EP9706135W WO9819684A3 WO 1998019684 A3 WO1998019684 A3 WO 1998019684A3 EP 9706135 W EP9706135 W EP 9706135W WO 9819684 A3 WO9819684 A3 WO 9819684A3
Authority
WO
WIPO (PCT)
Prior art keywords
lactulose
preparation
poured
aqueous
lactulose solution
Prior art date
Application number
PCT/EP1997/006135
Other languages
English (en)
French (fr)
Other versions
WO1998019684A2 (de
Inventor
Christiane Weissbach-Berger
Original Assignee
Fresenius Pharma Austria Gmbh
Christiane Weissbach-Berger
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fresenius Pharma Austria Gmbh, Christiane Weissbach-Berger filed Critical Fresenius Pharma Austria Gmbh
Publication of WO1998019684A2 publication Critical patent/WO1998019684A2/de
Publication of WO1998019684A3 publication Critical patent/WO1998019684A3/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7016—Disaccharides, e.g. lactose, lactulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/04—Disaccharides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Preparation (AREA)

Abstract

Es wird ein Verfahren zur Herstellung einer festen Lactulose-Zubereitung, aus einer wäßrigen Lactulose-Lösung in fester Form als streufähiges Granulat, bereitgestellt, worin man die wäßrige Lactulose-Lösung im Gegenstrom sprühtrocknet, wobei man die wäßrige Lactulose-Lösung in einen Wirbelschichtbehälter einsprüht, der eingesprühten wäßrigen Lactulose-Lösung Luft im Gegenstrom zuführt und die wäßrige Lactulose-Lösung auf eine Wirbelschicht aufsprüht, welche aus vorgelegter Trägersubstanz und/oder aus während des Trocknens der eingesprühten Lactulose-Lösung gebildeten Partikel besteht.
PCT/EP1997/006135 1996-11-06 1997-11-05 Herstellung von trockenen lactulose-arzneiformen WO1998019684A2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE1996145712 DE19645712A1 (de) 1996-11-06 1996-11-06 Herstellung von trockenen Lactulose-Arzneiformen
DE19645712.2 1996-11-06

Publications (2)

Publication Number Publication Date
WO1998019684A2 WO1998019684A2 (de) 1998-05-14
WO1998019684A3 true WO1998019684A3 (de) 1998-07-30

Family

ID=7810797

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1997/006135 WO1998019684A2 (de) 1996-11-06 1997-11-05 Herstellung von trockenen lactulose-arzneiformen

Country Status (2)

Country Link
DE (1) DE19645712A1 (de)
WO (1) WO1998019684A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6341106B1 (en) 1997-11-05 2002-01-22 Asahi Kogaku Kogyo Kabushiki Kaisha Optical disc drive
GB9827423D0 (en) * 1998-12-11 1999-02-03 Relax Limited Method of drying a solution
JP2004160165A (ja) * 2002-09-17 2004-06-10 Pauretsuku:Kk 生薬成分製剤の造粒方法
RU2541398C2 (ru) * 2013-07-02 2015-02-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Кемеровский технологический институт пищевой промышленности" Способ получения сухой лактулозы с помощью распылительной сушки
EP3629762A1 (de) * 2017-06-01 2020-04-08 Symrise AG Mehle als aromaträger

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3110600A (en) * 1960-04-22 1963-11-12 Tervalon Nv Method of drying a lactulosecontaining aqueous liquid
DE1189839B (de) * 1960-04-22 1965-03-25 Tervalon Mij Voor Voedingsmidd Verfahren zur Herstellung eines bifidusaktiven, streubaren Trockenproduktes aus einer Laktulose und Laktose enthaltenden waesserigen Loesung oder Suspension
DE2148159B1 (de) * 1971-09-27 1972-08-17 Monnaga Milk Industry Co Ltd , Tokio Verfahren zur Herstellung eines freifließenden Lactulosepulvers
FR2139791A1 (de) * 1971-05-31 1973-01-12 Morinaga Milk Industry Co Ltd
FR2315855A1 (fr) * 1975-07-04 1977-01-28 Morinaga Milk Industry Co Ltd Procede de preparation de poudres contenant du lactulose et nouveaux produits ainsi obtenus
JPS52151787A (en) * 1976-06-10 1977-12-16 Morinaga Milk Industry Co Ltd Bifidus strain powder containing lactulose

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3110600A (en) * 1960-04-22 1963-11-12 Tervalon Nv Method of drying a lactulosecontaining aqueous liquid
DE1189839B (de) * 1960-04-22 1965-03-25 Tervalon Mij Voor Voedingsmidd Verfahren zur Herstellung eines bifidusaktiven, streubaren Trockenproduktes aus einer Laktulose und Laktose enthaltenden waesserigen Loesung oder Suspension
FR2139791A1 (de) * 1971-05-31 1973-01-12 Morinaga Milk Industry Co Ltd
DE2148159B1 (de) * 1971-09-27 1972-08-17 Monnaga Milk Industry Co Ltd , Tokio Verfahren zur Herstellung eines freifließenden Lactulosepulvers
FR2315855A1 (fr) * 1975-07-04 1977-01-28 Morinaga Milk Industry Co Ltd Procede de preparation de poudres contenant du lactulose et nouveaux produits ainsi obtenus
JPS52151787A (en) * 1976-06-10 1977-12-16 Morinaga Milk Industry Co Ltd Bifidus strain powder containing lactulose

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 88, no. 20, 15 May 1978, Columbus, Ohio, US; abstract no. 141708, XP002065330 *

Also Published As

Publication number Publication date
DE19645712A1 (de) 1998-05-07
WO1998019684A2 (de) 1998-05-14

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