WO1998001440B1 - Compositions pharmaceutiques antivirales contenant des composes 1,2-dithiaheterocycliques satures et utilisation de ces compositions - Google Patents
Compositions pharmaceutiques antivirales contenant des composes 1,2-dithiaheterocycliques satures et utilisation de ces compositionsInfo
- Publication number
- WO1998001440B1 WO1998001440B1 PCT/US1997/010870 US9710870W WO9801440B1 WO 1998001440 B1 WO1998001440 B1 WO 1998001440B1 US 9710870 W US9710870 W US 9710870W WO 9801440 B1 WO9801440 B1 WO 9801440B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compound
- pharmaceutical composition
- saturated
- dithiaheterocyclic
- pharmaceutically acceptable
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract 24
- 150000001875 compounds Chemical class 0.000 title claims abstract 15
- 230000000840 anti-viral Effects 0.000 title claims abstract 3
- 239000000203 mixture Substances 0.000 claims abstract 11
- 208000001756 Virus Disease Diseases 0.000 claims abstract 5
- 241001430294 unidentified retrovirus Species 0.000 claims abstract 5
- 210000001124 Body Fluids Anatomy 0.000 claims abstract 3
- 239000010839 body fluid Substances 0.000 claims abstract 3
- 230000000415 inactivating Effects 0.000 claims abstract 2
- -1 1,2 dithiolane compound Chemical class 0.000 claims 11
- 239000003937 drug carrier Substances 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 239000011780 sodium chloride Substances 0.000 claims 7
- 125000005041 acyloxyalkyl group Chemical group 0.000 claims 5
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 5
- CXWGKAYMVASWDQ-UHFFFAOYSA-N Dithiane Chemical compound C1CCSSC1 CXWGKAYMVASWDQ-UHFFFAOYSA-N 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 230000003647 oxidation Effects 0.000 claims 4
- 238000007254 oxidation reaction Methods 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- 125000004434 sulfur atoms Chemical group 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 229910004730 OSO2 Inorganic materials 0.000 claims 2
- 206010047461 Viral infection Diseases 0.000 claims 2
- 125000004423 acyloxy group Chemical group 0.000 claims 2
- QGRBLDWNIGDYOW-UHFFFAOYSA-N dithiane 1,1-dioxide Chemical compound O=S1(=O)CCCCS1 QGRBLDWNIGDYOW-UHFFFAOYSA-N 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000004435 hydrogen atoms Chemical class [H]* 0.000 claims 2
- 230000017613 viral reproduction Effects 0.000 claims 2
- PAORVUMOXXAMPL-VIFPVBQESA-N (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoyl chloride Chemical compound CO[C@@](C(Cl)=O)(C(F)(F)F)C1=CC=CC=C1 PAORVUMOXXAMPL-VIFPVBQESA-N 0.000 claims 1
- 241001446316 Bohle iridovirus Species 0.000 claims 1
- 241000714266 Bovine leukemia virus Species 0.000 claims 1
- 241000713730 Equine infectious anemia virus Species 0.000 claims 1
- 208000005721 HIV Infections Diseases 0.000 claims 1
- 241000714260 Human T-lymphotropic virus 1 Species 0.000 claims 1
- 241000713340 Human immunodeficiency virus 2 Species 0.000 claims 1
- 241000713821 Mason-Pfizer monkey virus Species 0.000 claims 1
- 241000713333 Mouse mammary tumor virus Species 0.000 claims 1
- 241000724205 Rice stripe tenuivirus Species 0.000 claims 1
- 241000702287 Sugarcane streak virus Species 0.000 claims 1
- 208000010094 Visna Diseases 0.000 claims 1
- 125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 239000003443 antiviral agent Substances 0.000 claims 1
- 239000003899 bactericide agent Substances 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004432 carbon atoms Chemical group C* 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000004181 carboxyalkyl group Chemical group 0.000 claims 1
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 1
- 201000009910 diseases by infectious agent Diseases 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000002777 nucleoside Substances 0.000 claims 1
- 150000003833 nucleoside derivatives Chemical class 0.000 claims 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims 1
- 239000000934 spermatocidal agent Substances 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
Abstract
La présente invention concerne des compositions pharmaceutiques contenant des composés 1,2-dithiahétérocycliques saturés présentant une activité antivirale. L'invention concerne également un matériel contenant la compositions pharmaceutique. L'invention concerne aussi sur des thérapies permettant de soigner ou de prévenir une affection virale au moyen de ces compositions. L'invention concerne enfin des procédés d'inactivation rétrovirale dans un fluide organique.
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/214,331 US6046228A (en) | 1996-07-05 | 1997-07-03 | Anti-viral pharmaceutical compositions containing saturated 1,2-dithiaheterocyclic compounds and uses thereof |
| AU44085/97A AU737038B2 (en) | 1996-07-05 | 1997-07-03 | Anti-viral pharmaceutical compositions containing saturated 1,2-dithiaheterocyclic compounds and uses thereof |
| EP97942372A EP1023284B1 (fr) | 1996-07-05 | 1997-07-03 | Compositions pharmaceutiques antivirales contenant des composes 1,2-dithiaheterocycliques satures |
| AT97942372T ATE310738T1 (de) | 1996-07-05 | 1997-07-03 | Gesättigte 1,2-dithiaheterocyclische verbindungen enthaltende antivirale pharmazeutische zubereitungen |
| DE69734734T DE69734734D1 (de) | 1996-07-05 | 1997-07-03 | Gesättigte 1,2-dithiaheterocyclische verbindungen enthaltende antivirale pharmazeutische zubereitungen |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2166596P | 1996-07-05 | 1996-07-05 | |
| US60/021,665 | 1996-07-05 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| WO1998001440A2 WO1998001440A2 (fr) | 1998-01-15 |
| WO1998001440A3 WO1998001440A3 (fr) | 1998-05-14 |
| WO1998001440B1 true WO1998001440B1 (fr) | 1998-06-11 |
| WO1998001440A9 WO1998001440A9 (fr) | 1998-07-16 |
Family
ID=21805475
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1997/010870 WO1998001440A2 (fr) | 1996-07-05 | 1997-07-03 | Compositions pharmaceutiques antivirales contenant des composes 1,2-dithiaheterocycliques satures et utilisation de ces compositions |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6046228A (fr) |
| EP (1) | EP1023284B1 (fr) |
| AT (1) | ATE310738T1 (fr) |
| AU (1) | AU737038B2 (fr) |
| CA (1) | CA2260128A1 (fr) |
| DE (1) | DE69734734D1 (fr) |
| WO (1) | WO1998001440A2 (fr) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6417180B1 (en) * | 1998-10-07 | 2002-07-09 | University Of Massachusetts | Zinc finger-reactive antimicrobial compounds |
| EP1486495B1 (fr) * | 1998-10-26 | 2009-12-09 | The Research Foundation of State University of New York | Sels de dérives de l'acide lipoique et leur utilisation dans le traitement des maladies |
| US6204288B1 (en) | 1999-03-08 | 2001-03-20 | The University Of Mississippi | 1,2-dithiolane derivatives |
| US6288106B1 (en) * | 1999-05-25 | 2001-09-11 | Chronorx, Llc | Processes for the synthesis and use of various α-lipoic acid complexes |
| WO2001025226A1 (fr) * | 1999-10-05 | 2001-04-12 | Bethesda Pharmaceuticals, Inc. | Derives de dithiolane |
| US6664287B2 (en) * | 2000-03-15 | 2003-12-16 | Bethesda Pharmaceuticals, Inc. | Antioxidants |
| US6638915B1 (en) | 2000-06-30 | 2003-10-28 | Harold Killam | Anti-viral composition |
| EP1172110A3 (fr) * | 2000-07-07 | 2003-09-17 | Basf Aktiengesellschaft | Utilisation de l'acide lipoique pour augmenter la biodisponibilité de sels minéraux |
| AU2002322721B2 (en) | 2001-08-03 | 2009-01-08 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Acylthiols and component thiol compositions as anti-HIV and anti-retroviral agents |
| TWI281916B (en) * | 2001-10-25 | 2007-06-01 | Lilly Co Eli | Antitumor compounds and methods |
| DE10163836A1 (de) * | 2001-12-22 | 2003-07-10 | Friz Biochem Gmbh | Multifunktionales Reagenz zur Synthese von thiolmodifizierten Oligomeren |
| US7101676B2 (en) * | 2002-01-11 | 2006-09-05 | Douglas Buechter | Methods for identifying compounds which inhibit binding of nucleocapsid 7 protein to HIV-1 RNA |
| AU2003279916A1 (en) * | 2002-10-08 | 2004-05-04 | The Government Of The Usa As Represented By The Secretary Of The Dept. Of Health And Human Services | Identification of anti-hiv compounds inhibiting virus assembly and binding of nucleocapsid protein to nucleic acid |
| JP2010520333A (ja) | 2007-03-01 | 2010-06-10 | セダーズ−シナイ メディカル センター | 〔１，２〕−ジチオラン部分を含有する抗酸化剤重合体およびその使用 |
| US9028874B2 (en) | 2008-01-03 | 2015-05-12 | Cedars-Sinai Medical Center | Antioxidant nanosphere comprising [1,2]-dithiolane moieties |
| US8603531B2 (en) | 2008-06-02 | 2013-12-10 | Cedars-Sinai Medical Center | Nanometer-sized prodrugs of NSAIDs |
| ES2529060T3 (es) | 2008-11-24 | 2015-02-16 | Cedars-Sinai Medical Center | Derivados antioxidantes de la camptotecina y nanoesferas antineoplásicas antioxidantes de los mismos |
| US20130096092A1 (en) | 2010-06-10 | 2013-04-18 | Health And Human Services | Thioether prodrug compositions as anti-hiv and anti-retroviral agents |
| CA2832109C (fr) | 2011-06-10 | 2021-07-06 | Oregon Health & Science University | Glycoproteines de cmv et vecteurs recombinants cmv |
| JP6480340B2 (ja) | 2012-11-15 | 2019-03-06 | ブランデイズ ユニバーシティー | 環状ジスルフィドを用いるシステイン残基のテザリング |
| KR20150092243A (ko) * | 2012-12-06 | 2015-08-12 | 머크 샤프 앤드 돔 코포레이션 | 뉴클레오시드 키나제 우회 조성물 및 방법 |
| WO2015035003A1 (fr) | 2013-09-05 | 2015-03-12 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Compositions de promédicament thioéther utilisées comme agents anti-vih et antirétroviraux |
| WO2017017669A1 (fr) * | 2015-07-24 | 2017-02-02 | Aposense Ltd. | Promédicaments et méthodes associées |
| WO2017031226A1 (fr) | 2015-08-18 | 2017-02-23 | Brandeis University | Résidus de cystéine d'attache utilisant des disulfures cycliques |
| WO2022049219A1 (fr) | 2020-09-02 | 2022-03-10 | Université De Genève | Méthodes de traitement d'une infection virale |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3158621A (en) * | 1962-06-20 | 1964-11-24 | American Cyanamid Co | Dithiolium compounds and their preparation |
| CH656382A5 (de) * | 1983-10-24 | 1986-06-30 | Sandoz Ag | Sulfoxide, verfahren zu ihrer herstellung und ihre verwendung. |
| ES2038733T3 (es) * | 1987-12-04 | 1993-08-01 | Asta Medica Ag | Procedimiento para preparar una solucion inyectable de la sal de acido tioctico con trometanol y/o aminoacidos basicos. |
| JPH03188021A (ja) * | 1989-11-09 | 1991-08-16 | Asta Pharma Ag | レトロウイルスを撲滅するための医薬品およびその製造法 |
| DE69122264T2 (de) * | 1990-11-13 | 1997-02-06 | Iaf Biochem Int | Substituierte 1,3-oxathiolane mit antiviralen eigenschaften |
| FR2676057B1 (fr) * | 1991-05-02 | 1995-03-03 | Therapeutique Moder Lab | Derives de 1,2-dithiole-3-thione, procede de preparation de ces derives, ainsi que l'utilisation de ces derives comme intermediaires de synthese ou comme medicaments. |
| US6001555A (en) * | 1994-09-23 | 1999-12-14 | The United States Of America As Represented By The Department Of Health And Human Services | Method for identifying and using compounds that inactivate HIV-1 and other retroviruses by attacking highly conserved zinc fingers in the viral nucleocapsid protein |
| US5693460A (en) * | 1996-06-24 | 1997-12-02 | Eastman Kodak Company | Silver halide photographic elements containing dioxide compunds a stabilizers |
| EP0855396A1 (fr) * | 1997-01-22 | 1998-07-29 | ASTA Medica Aktiengesellschaft | Métabolites de l'acide thioctique et leur utilisation |
-
1997
- 1997-07-03 DE DE69734734T patent/DE69734734D1/de not_active Expired - Lifetime
- 1997-07-03 US US09/214,331 patent/US6046228A/en not_active Expired - Lifetime
- 1997-07-03 AT AT97942372T patent/ATE310738T1/de not_active IP Right Cessation
- 1997-07-03 EP EP97942372A patent/EP1023284B1/fr not_active Expired - Lifetime
- 1997-07-03 CA CA002260128A patent/CA2260128A1/fr not_active Abandoned
- 1997-07-03 WO PCT/US1997/010870 patent/WO1998001440A2/fr active IP Right Grant
- 1997-07-03 AU AU44085/97A patent/AU737038B2/en not_active Ceased
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