WO1997046251A1 - aPL IMMUNOREACTIVE PEPTIDES, CONJUGATES THEREOF AND METHODS OF TREATMENT FOR aPL ANTIBODY-MEDIATED PATHOLOGIES - Google Patents

aPL IMMUNOREACTIVE PEPTIDES, CONJUGATES THEREOF AND METHODS OF TREATMENT FOR aPL ANTIBODY-MEDIATED PATHOLOGIES Download PDF

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Publication number
WO1997046251A1
WO1997046251A1 PCT/US1997/010075 US9710075W WO9746251A1 WO 1997046251 A1 WO1997046251 A1 WO 1997046251A1 US 9710075 W US9710075 W US 9710075W WO 9746251 A1 WO9746251 A1 WO 9746251A1
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WIPO (PCT)
Prior art keywords
apl
phage
antibody
peptide
analog
Prior art date
Application number
PCT/US1997/010075
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English (en)
French (fr)
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WO1997046251A9 (en
Inventor
Edward Jess Victoria
David Matthew Marquis
David S. Jones
Lin Yu
Original Assignee
Lajolla Pharmaceutical Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/660,092 external-priority patent/US6207160B1/en
Application filed by Lajolla Pharmaceutical Company filed Critical Lajolla Pharmaceutical Company
Priority to JP10500927A priority Critical patent/JP2000512981A/ja
Priority to CA002256449A priority patent/CA2256449A1/en
Priority to EP97933138A priority patent/EP0954531A1/de
Priority to AU36404/97A priority patent/AU734638B2/en
Publication of WO1997046251A1 publication Critical patent/WO1997046251A1/en
Publication of WO1997046251A9 publication Critical patent/WO1997046251A9/en
Priority to NO985636A priority patent/NO985636L/no

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/03—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in eptitope analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6093—Synthetic polymers, e.g. polyethyleneglycol [PEG], Polymers or copolymers of (D) glutamate and (D) lysine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Definitions

  • Antiphospholipid antibodies occur in autoimmune diseases such as systemic lupus erythematosus (SLE) and antiphospholipid antibody syndrome (APS) as well as in association with infections and drug therapy.
  • SLE systemic lupus erythematosus
  • APS antiphospholipid antibody syndrome
  • APS is characterized by one or more clinical features such as arterial or venous thrombosis, thrombocytopenia and fetal loss.
  • APS may be primary or it may be associated with other conditions, primarily SLE (PHOSPHOLIPID-BINDING ANTIBODIES (Harris et al., eds., CRC Press, Boca Raton, FL, 1991); McNeil et al. ADVANCES IN IMMUNOLOGY, Vol. 49, pp.
  • the invention also encompasses a method of biopanning phage random peptide libraries to identify and isolate peptides which bind to aPL antibody comprising: (a) reacting affinity-purified aPL antibody with phage bearing random peptide inserts; (b) recovering phage bearing random peptide inserts which bind to the aPL antibody; (c) infecting a microorganism with phage recovered in (b); and (d) culturing the infected microorganism in an antibiotic-containing medium in order to isolate the phage.
  • aPL-specific epitope represent the analogs of the aPL-specific epitope. These peptides are then synthesized and ranked for strength of binding using competition assays.
  • Another aspect of the invention is aPL antibody-binding analogs that bind specifically to B cells to which an aPL epitope binds. Optimized analogs lack T cell epitope(s).
  • Figure 2 shows that resin-bound analog 5A12 immunospecifically binds to affinity-purified IgG designated ACA-6501.
  • Figure 8 illustrates the dramatic drop in sequence diversity of the isolated clones by the fourth round of biopanning.
  • Figure 9 illustrates that three clones (3A12, 3B3 and 3A5) exhibited a very strong immunospecific signal in the phage-capture ELISA using ACA-6635 whereas all clones tested were unreactive with normal IgG.
  • the analog may be a peptide, carbohydrate, lipid, lipopolysaccharide, nucleic acid or other biochemical entity. Further, the chemical structure of neither the immunogen nor the analog need be defined for the purposes of this invention.
  • the term “analog” of an immunogen also encompasses the term “mimotope.”
  • the term “mimotope” intends a molecule which competitively inhibits the antibody from binding the immunogen. Because it specifically binds the antibody, the mimotope is considered to mimic the antigenic determinants of the immunogen.
  • T cell epitopes can also be determined by measuring secretion of T cell-derived lymphokines by methods well known in the art. Analogs that fail to induce statistically significant incorporation of thymidine above background are deemed to lack T cell epitopes. It will be appreciated that the quantitative amount of thymidine incorporation may vary with the immunogen. Typically a stimulation index below about 2-3, more usually about 1-2, is indicative of a lack of T cell epitopes.
  • Conjugation of the aPL antibody-binding analog to the valency platform molecule may be effected in any number of ways, typically involving one or more crosslinking agents and functional groups on the analog and valency platform molecule.
  • the "y” library is the same as the “y”' library except that it lacks the 6 and 8 amino acid inserts. These peptide inserts for both “y” and “y' “ libraries are flanked by cysteine residues at both the amino and carboxyl ends to form cyclic, more rigid structures. Proline residues are incorporated outside these cysteine residues for reasons similar to those for the "x” libraries above.
  • the "x,” “y' “, and “y” libraries are located five residues from the amino terminus of the native p-III protein.
  • the "z” library consists of random eight amino acid inserts located at the amino terminus of the p-III protein and do not contain any flanking proline or cysteine residues. A combination of the "x,” “y' “ and “z” libraries represents eleven different libraries each with approximately one hundred million different peptide inserts.
  • a Tolerogen For a Tolerogen to be generally effective, it must bind a major portion of the aPL antibodies in the majority of patients. It is important to determine if several antibodies from different patients bind identical residues within the eighty-four amino acid 5th domain of ⁇ 2 -GPI which has been suggested by others to contain the target epitope. If several antibodies bind identical residues, a single mimotope derived from the structural data of the peptides can be constructed which will react with all the antibodies. On the other hand, if the antibodies bind to different residues, a unique tolerogen would be required for each antibody. Site-directed mutagenesis was performed to identify if key residues involved in aPL antibody binding reside in the 5th domain of ⁇ 2 -GPI.
  • BSA bovine serum albumin
  • Phage to be tested by micropanning were obtained from the agar plates generated by biopanning. Each clone to be tested was transferred using sterile toothpicks to a separate well of a round-bottom 96-well microtitration plate (Corning, Corning, NY) containing 250 ⁇ L 2YT/Tet per well and cultured overnight at 37°C. Clone designations are based on the screening antibody, the biopanning round of origin, and the location of the clone in the overnight culture plate, e.g., ACA- 6501/3B10 refers to the clone isolated by ACA-6501 in the third round located in the well designated BIO on the microtitration plate. Following overnight incubation, phage cultures were centrifuged using a microtitration plate holder at 1300 x g for 10 minutes at RT. Supernatants constituted the source of "neat" phage.
  • variable amounts of each of six peptides were mixed with 22 ⁇ L ACA-6501 serum diluted with 3% fish gelatin in 1 :1 TBS/PBS (final dilution of 1 :400) in a final volume of 220 ⁇ L using Eppendorf microcentrifuge tubes.
  • tube #1 were mixed 181.3 ⁇ L of 3% fish gelatin in TBS-PBS, 16.7 ⁇ L of peptide stock solution plus 22 ⁇ L of ACA-6501 serum diluted 40 times in 3% fish gelatin/TBS -PBS.
  • variable amounts of each of four test peptides were mixed with 22 ⁇ L of ACA-6501 serum diluted with sample diluent in a final volume of 220 ⁇ L using Eppendorf microcentrifuge tubes. Specifically, in tube #1, 188 ⁇ L of sample diluent, 10 ⁇ L of peptide stock solution (2 mg - 4 mg/mL diluent), and 22 ⁇ L of AC-6501 serum diluted 1 :35 in sample diluent were added. To tube #2, 158 ⁇ L sample diluent, 40 ⁇ L peptide stock solution and 22 ⁇ L of 1 :35 diluted ACA-6501 serum were added.
  • the residue was triturated with 2 X 50 mL of Et 2 O and the white opaque residue was treated with 5 mL of 92/3/2/3 TFA/anisole/EDT/Me 2 S for 1 hour.
  • the product was precipitated by adding the mixture to 40 mL of Et 2 O in a 50 mL polypropylene centrifuge tube. The precipitate was cooled to 0°C and centrifuged for 5 minutes at 2000 rpm. The supernatant was decanted and the pellet was washed with Et 2 O and recentrifuged. The pellet was dried and dissolved in 4 mL of 50/50 CH 3 CN/H 2 O.
  • the thiobenzoate ester, compound 28 was prepared from compound 27.
  • Example 15 Synthesis of a (LJP685) 4 /MTU-ATU-AHAB-TEG conjugate,

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PCT/US1997/010075 1996-06-06 1997-06-06 aPL IMMUNOREACTIVE PEPTIDES, CONJUGATES THEREOF AND METHODS OF TREATMENT FOR aPL ANTIBODY-MEDIATED PATHOLOGIES WO1997046251A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP10500927A JP2000512981A (ja) 1996-06-06 1997-06-06 ａＰＬ免疫応答性ペプチド、その結合体およびａＰＬ抗体媒介病理のための処置方法
CA002256449A CA2256449A1 (en) 1996-06-06 1997-06-06 Apl immunoreactive peptides, conjugates thereof and methods of treatment for apl antibody-mediated pathologies
EP97933138A EP0954531A1 (de) 1996-06-06 1997-06-06 Apl-immunreaktive peptide, deren konjugate und verfahren zur behandlung von apl-antikörpern vermittelten krankheiten
AU36404/97A AU734638B2 (en) 1996-06-06 1997-06-06 aPL immunoreactive peptides, conjugates thereof and methods of treatment for aPL antibody-mediated pathologies
NO985636A NO985636L (no) 1996-06-06 1998-12-03 aPL immunoreaktive peptider, konjugater derav og metoder for behandling av aPL antistoff-medierte patologier

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/660,092 1996-06-06
US08/660,092 US6207160B1 (en) 1995-06-07 1996-06-06 aPL immunoreactive peptides, conjugates thereof and methods of treatment for aPL antibody-mediated pathologies
US76050896A 1996-12-05 1996-12-05
US08/760,508 1996-12-05

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WO1997046251A1 true WO1997046251A1 (en) 1997-12-11
WO1997046251A9 WO1997046251A9 (en) 1998-06-04

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EP (1) EP0954531A1 (de)
JP (1) JP2000512981A (de)
KR (1) KR20000016414A (de)
AU (1) AU734638B2 (de)
CA (1) CA2256449A1 (de)
NO (1) NO985636L (de)
WO (1) WO1997046251A1 (de)

Cited By (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999064595A1 (en) * 1998-06-09 1999-12-16 La Jolla Pharmaceutical Company THERAPEUTIC AND DIAGNOSTIC DOMAIN 1 β2GPI POLYPEPTIDES AND METHODS OF USING SAME
US6040136A (en) * 1990-12-03 2000-03-21 Genentech, Inc. Enrichment method for variant proteins with altered binding properties
WO2001013110A2 (en) * 1999-08-17 2001-02-22 Osteometer Biotech A/S Detection of isomerised epitopes in autoimmune diseases
US6197526B1 (en) 1999-01-04 2001-03-06 Dyax Corp. Polypeptides for binding human factor VIII and fragments of human factor VIII
US6207160B1 (en) 1995-06-07 2001-03-27 La Jolla Pharmaceutical Company aPL immunoreactive peptides, conjugates thereof and methods of treatment for aPL antibody-mediated pathologies
WO2001032858A1 (en) * 1999-11-05 2001-05-10 Novozymes A/S A high throughput screening (hts) method
US6238860B1 (en) 1998-11-05 2001-05-29 Dyax Corp. Binding moieties for human parvovirus B19
US6399578B1 (en) 1998-12-09 2002-06-04 La Jolla Pharmaceutical Company Conjugates comprising galactose α1,3 galactosyl epitopes and methods of using same
WO2002064612A2 (en) 2001-02-09 2002-08-22 Human Genome Sciences, Inc. Human g-protein chemokine receptor (ccr5) hdgnr10
US6458953B1 (en) 1998-12-09 2002-10-01 La Jolla Pharmaceutical Company Valency platform molecules comprising carbamate linkages
WO2006028742A2 (en) 2004-09-01 2006-03-16 Dynavax Technologies Corporation Methods and conpositions for inhibition of innate immune responses and autoimmunity
US7081242B1 (en) 1999-11-28 2006-07-25 La Jolla Pharmaceutical Company Methods of treating lupus based on antibody affinity and screening methods and compositions for use thereof
US7112438B2 (en) 1999-01-04 2006-09-26 Dyax Corp. Binding molecules for human factor VIII and factor VIII-like proteins
US7118872B2 (en) 2000-08-18 2006-10-10 Dyax Corp. Binding polypeptides for B lymphocyte stimulator protein (BLyS)
US7255868B2 (en) 2001-06-21 2007-08-14 Dynavax Technologies Corporation Chimeric immunomodulatory compounds and methods of using the same—I
WO2008021290A2 (en) 2006-08-09 2008-02-21 Homestead Clinical Corporation Organ-specific proteins and methods of their use
WO2008032833A1 (fr) 2006-09-14 2008-03-20 Medical & Biological Laboratories Co., Ltd. Anticorps présentant une activité adcc accrue et son procédé de production
WO2008103962A2 (en) 2007-02-22 2008-08-28 Genentech, Inc. Methods for detecting inflammatory bowel disease
EP1992643A2 (de) 2001-06-20 2008-11-19 Genentech, Inc. Zusammensetzungen und Verfahren zur Behandlung und Diagnose von Tumoren
EP2011886A2 (de) 2002-04-16 2009-01-07 Genentech, Inc. Zusammensetzungen und Verfahren zur Behandlung und Diagnose von Tumoren
EP2050763A2 (de) 2005-03-10 2009-04-22 Genentech, Inc. Verfahren und Zusammensetzungen zur Modulation der Gefäßintegrität
EP2067472A1 (de) 2002-01-02 2009-06-10 Genentech, Inc. Zusammensetzungen und Verfahren zur Behandlung und Diagnose von Tumoren
EP2080766A1 (de) 2001-06-06 2009-07-22 Bristol-Myers Squibb Company Zur Immunmodulation nützliche B7-verwandte Nukleinsäuren und Polypeptide
US7605236B2 (en) 2000-06-16 2009-10-20 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to B lymphocyte stimulator protein
WO2009154025A1 (ja) 2008-06-20 2009-12-23 国立大学法人岡山大学 酸化LDL/β2GPI複合体に対する抗体及びその用途
EP2143438A1 (de) 2001-09-18 2010-01-13 Genentech, Inc. Zusammensetzungen und Verfahren zur Behandlung und Diagnose von Tumoren
EP2161283A1 (de) 2003-11-17 2010-03-10 Genentech, Inc. Zusammensetzungen, die Antikörper gegen CD79b enthalten, die an Wachstumshemmer oder an zytotoxische Subtanzen gekoppelt sind und Verfahren zur Behandlung von Tumoren hämatopoetischen Ursprungs
EP2228389A2 (de) 2001-04-13 2010-09-15 Human Genome Sciences, Inc. Antikörper gegen vaskulären Endothelwachstumsfaktor 2
EP2277908A2 (de) 2003-07-08 2011-01-26 Genentech, Inc. Heterologe IL-17A/F-Polypeptide, Antikörper und deren therapeutische Verwendungen
US7879328B2 (en) 2000-06-16 2011-02-01 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to B lymphocyte stimulator
US7884083B2 (en) 2002-08-12 2011-02-08 Dynavax Technologies Corporation Immunomodulatory compositions, methods of making, and methods of use thereof
WO2011050194A1 (en) 2009-10-22 2011-04-28 Genentech, Inc. Methods and compositions for modulating hepsin activation of macrophage-stimulating protein
WO2011066503A2 (en) 2009-11-30 2011-06-03 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
EP2354254A1 (de) 2006-09-06 2011-08-10 Ortho-McNeil Pharmaceutical, Inc. Biomarker zur Überprüfung der Reaktion auf eine C-Met-Behandlung
EP2361980A1 (de) 2007-10-26 2011-08-31 Dynavax Technologies Corporation Verfahren und Zusammensetzungen zur Hemmung von Immunantworten und Autoimmunität
WO2011106297A2 (en) 2010-02-23 2011-09-01 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
WO2011139985A1 (en) 2010-05-03 2011-11-10 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
US8062906B2 (en) 2000-08-18 2011-11-22 Human Genome Sciences, Inc. B-lymphocyte stimulator binding polypeptides and methods based thereon
US8071092B1 (en) 1996-10-25 2011-12-06 Human Genome Sciences, Inc. Methods of inhibiting B lymphocytes using antibodies to Neutrokine-alpha
WO2011159958A2 (en) 2010-06-16 2011-12-22 Dynavax Technologies Corporation Methods of treatment using tlr7 and/or tlr9 inhibitors
EP2450050A1 (de) 2006-11-29 2012-05-09 Genentech, Inc. Heterodimere IL-17A/F-Polypeptide und ihre therapeutische Verwendung
US8211649B2 (en) 2006-03-31 2012-07-03 Human Genome Sciences, Inc. Methods of diagnosing and prognosing hodgkin's lymphoma
US8212004B2 (en) 1999-03-02 2012-07-03 Human Genome Sciences, Inc. Neutrokine-alpha fusion proteins
WO2013040433A1 (en) 2011-09-15 2013-03-21 Genentech, Inc. Methods of promoting differentiation
WO2013056148A2 (en) 2011-10-15 2013-04-18 Genentech, Inc. Methods of using scd1 antagonists
EP2599793A1 (de) 2008-05-29 2013-06-05 Nuclea Biotechnologies, Inc. Anti-Phosphor-AKT-Antikörper
EP2614839A2 (de) 2006-04-05 2013-07-17 Genentech, Inc. Verfahren zur Verwendung von BOC/CDO zur Modulation der Hedgehog-Signalisierung
WO2013109856A2 (en) 2012-01-18 2013-07-25 Genentech, Inc. Methods of using fgf19 modulators
WO2013120056A1 (en) 2012-02-11 2013-08-15 Genentech, Inc. R-spondin translocations and methods using the same
WO2013137920A1 (en) 2012-03-16 2013-09-19 Genentech, Inc. Engineered conformationally-stabilized proteins
WO2013135745A1 (en) 2012-03-16 2013-09-19 F. Hoffmann-La Roche Ag Methods of treating melanoma with pak1 inhibitors
WO2013162654A1 (en) 2012-04-25 2013-10-31 Biodesy, Llc Methods for detecting allosteric modulators of proteins
WO2013170191A1 (en) 2012-05-11 2013-11-14 Genentech, Inc. Methods of using antagonists of nad biosynthesis from nicotinamide
US8685893B2 (en) 1998-07-27 2014-04-01 Genentech, Inc. Phage display
WO2014052931A1 (en) 2012-09-29 2014-04-03 Dynavax Technologies Corporation Human toll-like receptor inhibitors and methods of use thereof
WO2014151006A2 (en) 2013-03-15 2014-09-25 Genentech, Inc. Biomarkers and methods of treating pd-1 and pd-l1 related conditions
US8937169B2 (en) 1996-01-11 2015-01-20 Human Genome Sciences, Inc. Human G-protein chemokine receptor HSATU68
WO2015116902A1 (en) 2014-01-31 2015-08-06 Genentech, Inc. G-protein coupled receptors in hedgehog signaling
US9139863B2 (en) 2012-03-16 2015-09-22 Genentech, Inc. Engineered conformationally-stabilized proteins
US9168286B2 (en) 2005-10-13 2015-10-27 Human Genome Sciences, Inc. Methods and compositions for use in treatment of patients with autoantibody positive disease
US9182406B2 (en) 2008-08-04 2015-11-10 Biodesy, Inc. Nonlinear optical detection of molecules comprising an unnatural amino acid possessing a hyperpolarizability
WO2015179835A2 (en) 2014-05-23 2015-11-26 Genentech, Inc. Mit biomarkers and methods using the same
US9428789B2 (en) 2011-03-21 2016-08-30 Biodesy, Inc. Classification of kinase inhibitors using nonlinear optical techniques
WO2018049275A1 (en) 2016-09-09 2018-03-15 Genentech, Inc. Selective peptide inhibitors of frizzled
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US10562946B2 (en) 2014-06-20 2020-02-18 Genentech, Inc. Chagasin-based scaffold compositions, methods, and uses
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CN112480209A (zh) * 2020-11-16 2021-03-12 昆明学院 一种抗皮肤光损伤保护活性多肽rl-pl9及其应用

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2703499T3 (es) * 2010-12-22 2019-03-11 Salk Inst Biological Studies Péptidos antagonistas de CRF cíclicos

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5268454A (en) * 1991-02-08 1993-12-07 La Jolla Pharmaceutical Company Composition for inducing humoral anergy to an immunogen comprising a t cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic carrier
US5344758A (en) * 1990-04-06 1994-09-06 Yamasa Shoyu Kabushiki Kaisha Methods for determining anti-phospholipid and anti-cardiolipin antibodies
US5498538A (en) * 1990-02-15 1996-03-12 The University Of North Carolina At Chapel Hill Totally synthetic affinity reagents
US5506110A (en) * 1989-10-19 1996-04-09 Yamasa Shoyu Kabushiki Kaisha Carrier for binding of anti-phospholipid antibodies, and immunoassay method using the same and a kit therefor
US5552391A (en) * 1990-01-16 1996-09-03 La Jolla Pharmaceutical Company Chemically-defined non-polymeric valency platform molecules and conjugates thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0523035B1 (de) * 1990-04-10 1994-10-12 Masur, Walter Verfahren zum betreiben einer kompressionswärmepumpe, sowie kompressionswärmepumpe
DK0642798T3 (da) * 1993-09-08 2007-09-10 Jolla Pharma Kemisk definerede, ikke polymere valensplatformmolekyler og konjugater deraf
US5874409A (en) * 1995-06-07 1999-02-23 La Jolla Pharmaceutical Company APL immunoreactive peptides, conjugates thereof and methods of treatment for APL antibody-mediated pathologies

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5506110A (en) * 1989-10-19 1996-04-09 Yamasa Shoyu Kabushiki Kaisha Carrier for binding of anti-phospholipid antibodies, and immunoassay method using the same and a kit therefor
US5552391A (en) * 1990-01-16 1996-09-03 La Jolla Pharmaceutical Company Chemically-defined non-polymeric valency platform molecules and conjugates thereof
US5498538A (en) * 1990-02-15 1996-03-12 The University Of North Carolina At Chapel Hill Totally synthetic affinity reagents
US5344758A (en) * 1990-04-06 1994-09-06 Yamasa Shoyu Kabushiki Kaisha Methods for determining anti-phospholipid and anti-cardiolipin antibodies
US5268454A (en) * 1991-02-08 1993-12-07 La Jolla Pharmaceutical Company Composition for inducing humoral anergy to an immunogen comprising a t cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic carrier

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF INVESTIGATIVE MEDICINE, January 1996, Vol. 44, No. 1, GHARAVI et al., "Induction of Antiphospholipid Antibodies by Immunization with a 15-Amino Acid Peptide Spanning the Phospholipid Binding Site of B2 Glycoprotein I", page 694. *
See also references of EP0954531A4 *

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6040136A (en) * 1990-12-03 2000-03-21 Genentech, Inc. Enrichment method for variant proteins with altered binding properties
US6207160B1 (en) 1995-06-07 2001-03-27 La Jolla Pharmaceutical Company aPL immunoreactive peptides, conjugates thereof and methods of treatment for aPL antibody-mediated pathologies
US8937169B2 (en) 1996-01-11 2015-01-20 Human Genome Sciences, Inc. Human G-protein chemokine receptor HSATU68
US8071092B1 (en) 1996-10-25 2011-12-06 Human Genome Sciences, Inc. Methods of inhibiting B lymphocytes using antibodies to Neutrokine-alpha
US8303951B2 (en) 1996-10-25 2012-11-06 Human Genome Sciences, Inc. Neutrokine-alpha antibodies and methods of use thereof
US8231873B2 (en) 1996-10-25 2012-07-31 Human Genome Sciences, Inc. Methods of treatment using antibodies to Neutrokine-alpha
US8173122B2 (en) 1996-10-25 2012-05-08 Human Genome Sciences, Inc. Methods of treatment using antibodies to neutrokine-alpha
AU772851B2 (en) * 1998-06-09 2004-05-06 La Jolla Pharmaceutical Company Therapeutic and diagnostic domain 1 beta2GPI polypeptides and methods of using same
WO1999064595A1 (en) * 1998-06-09 1999-12-16 La Jolla Pharmaceutical Company THERAPEUTIC AND DIAGNOSTIC DOMAIN 1 β2GPI POLYPEPTIDES AND METHODS OF USING SAME
US6858210B1 (en) 1998-06-09 2005-02-22 La Jolla Pharmaceutical Co. Therapeutic and diagnostic domain 1 β2GPI polypeptides and methods of using same
US8685893B2 (en) 1998-07-27 2014-04-01 Genentech, Inc. Phage display
US6291197B1 (en) 1998-11-05 2001-09-18 Dyax Corp. Binding moieties for human parvovirus B19
US6479641B2 (en) 1998-11-05 2002-11-12 Dyax Corp. Binding moieties for human parvovirus B19
US6238860B1 (en) 1998-11-05 2001-05-29 Dyax Corp. Binding moieties for human parvovirus B19
US6399578B1 (en) 1998-12-09 2002-06-04 La Jolla Pharmaceutical Company Conjugates comprising galactose α1,3 galactosyl epitopes and methods of using same
US6458953B1 (en) 1998-12-09 2002-10-01 La Jolla Pharmaceutical Company Valency platform molecules comprising carbamate linkages
US7112438B2 (en) 1999-01-04 2006-09-26 Dyax Corp. Binding molecules for human factor VIII and factor VIII-like proteins
EP2301953A1 (de) 1999-01-04 2011-03-30 Dyax Corp. Binden von Molekülen für den menschlichen Faktor VIII und Faktor-VIII-artige Proteine
US8058017B2 (en) 1999-01-04 2011-11-15 Dyax Corp. Methods and compositions for purifying human factor VIII, factor VIII-like proteins or fragments thereof
EP2090582A2 (de) 1999-01-04 2009-08-19 Dyax Corporation Binden von Molekülen für den menschlichen Faktor VIII und faktor-VIII-artige Proteine
US7691565B2 (en) 1999-01-04 2010-04-06 Dyax Corp. Binding molecules for human factor VIII and factor VIII-like proteins
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US6197526B1 (en) 1999-01-04 2001-03-06 Dyax Corp. Polypeptides for binding human factor VIII and fragments of human factor VIII
US8535892B2 (en) 1999-01-04 2013-09-17 Dyax Corp. Binding molecules for human factor VIII and factor VIII-like proteins
US6492105B2 (en) 1999-01-04 2002-12-10 Dyax Corp. Binding molecules for human factor VIII and factor VIII-like proteins
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WO2001032858A1 (en) * 1999-11-05 2001-05-10 Novozymes A/S A high throughput screening (hts) method
US7081242B1 (en) 1999-11-28 2006-07-25 La Jolla Pharmaceutical Company Methods of treating lupus based on antibody affinity and screening methods and compositions for use thereof
US7605236B2 (en) 2000-06-16 2009-10-20 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to B lymphocyte stimulator protein
US9187548B2 (en) 2000-06-16 2015-11-17 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to B lymphocyte stimulator protein
US8101181B2 (en) 2000-06-16 2012-01-24 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to B lymphocyte stimulator protein
US7879328B2 (en) 2000-06-16 2011-02-01 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to B lymphocyte stimulator
US8062906B2 (en) 2000-08-18 2011-11-22 Human Genome Sciences, Inc. B-lymphocyte stimulator binding polypeptides and methods based thereon
US7118872B2 (en) 2000-08-18 2006-10-10 Dyax Corp. Binding polypeptides for B lymphocyte stimulator protein (BLyS)
EP2267016A2 (de) 2000-08-18 2010-12-29 Human Genome Sciences, Inc. Polypeptide zur Bindung an das B-Lymphozyten-stimulatorische Protein (BLyS)
EP2270040A2 (de) 2000-08-18 2011-01-05 Human Genome Sciences, Inc. Polypeptide zur Bindung an das B-Lymphozyten-stimulatorische Protein (BLyS)
EP2267017A2 (de) 2000-08-18 2010-12-29 Human Genome Sciences, Inc. Polypeptide zur Bindung an das B-Lymphozyten-stimulatorische Protein (BLyS)
EP2261246A2 (de) 2000-08-18 2010-12-15 Human Genome Sciences, Inc. Polypeptide zur Bindung an das B-Lymphozyten-stimulatorische Protein (BLyS)
EP2267015A2 (de) 2000-08-18 2010-12-29 Human Genome Sciences, Inc. Polypeptide zur Bindung an das B-Lymphozyten-stimulatorische Protein (BLyS)
EP2267020A2 (de) 2000-08-18 2010-12-29 Human Genome Sciences, Inc. Polypeptide zur Bindung an das B-Lymphozyten-stimulatorische Protein (BLyS)
EP2267018A2 (de) 2000-08-18 2010-12-29 Human Genome Sciences, Inc. Polypeptide zur Bindung an das B-Lymphozyten-stimulatorische Protein (BLyS)
EP2267019A2 (de) 2000-08-18 2010-12-29 Human Genome Sciences, Inc. Polypeptide zur Bindung an das B-Lymphozyten-stimulatorische Protein (BLyS)
WO2002064612A2 (en) 2001-02-09 2002-08-22 Human Genome Sciences, Inc. Human g-protein chemokine receptor (ccr5) hdgnr10
EP2228389A2 (de) 2001-04-13 2010-09-15 Human Genome Sciences, Inc. Antikörper gegen vaskulären Endothelwachstumsfaktor 2
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EP2000148A1 (de) 2001-06-20 2008-12-10 Genentech, Inc. Zusammensetzungen und Verfahren zur Behandlung und Diagnose von Prostatakarzinom
EP1992643A2 (de) 2001-06-20 2008-11-19 Genentech, Inc. Zusammensetzungen und Verfahren zur Behandlung und Diagnose von Tumoren
EP2000482A1 (de) 2001-06-20 2008-12-10 Genentech, Inc. Zusammensetzungen und Verfahren zur Behandlung und Diagnose von Tumoren
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EP2423335A2 (de) 2001-06-21 2012-02-29 Dynavax Technologies Corporation Chimäre immunmodulierende Verbindungen und Verwendungsverfahren dafür
US7255868B2 (en) 2001-06-21 2007-08-14 Dynavax Technologies Corporation Chimeric immunomodulatory compounds and methods of using the same—I
US9028845B2 (en) 2001-06-21 2015-05-12 Dynavax Technologies Corporation Chimeric immunomodulatory compounds and methods of using the same-IV
EP2151244A1 (de) 2001-09-18 2010-02-10 Genentech, Inc. Zusammensetzungen und Verfahren zur Behandlung und Diagnose von Tumoren
EP2153843A1 (de) 2001-09-18 2010-02-17 Genentech, Inc. Zusammensetzungen und Verfahren zur Behandlung und Diagnose von Tumoren
EP2143438A1 (de) 2001-09-18 2010-01-13 Genentech, Inc. Zusammensetzungen und Verfahren zur Behandlung und Diagnose von Tumoren
EP2067472A1 (de) 2002-01-02 2009-06-10 Genentech, Inc. Zusammensetzungen und Verfahren zur Behandlung und Diagnose von Tumoren
EP2011886A2 (de) 2002-04-16 2009-01-07 Genentech, Inc. Zusammensetzungen und Verfahren zur Behandlung und Diagnose von Tumoren
US7884083B2 (en) 2002-08-12 2011-02-08 Dynavax Technologies Corporation Immunomodulatory compositions, methods of making, and methods of use thereof
EP2277908A2 (de) 2003-07-08 2011-01-26 Genentech, Inc. Heterologe IL-17A/F-Polypeptide, Antikörper und deren therapeutische Verwendungen
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EP2784084A1 (de) 2003-07-08 2014-10-01 Genentech, Inc. Heterologe IL-17A/F-Polypeptide und deren therapeutische Verwendungen
EP2301568A1 (de) 2003-11-17 2011-03-30 Genentech, Inc. Antikörper gegen IRTA2 für die Behandlung von hämatopoetischen Tumoren
EP2295073A1 (de) 2003-11-17 2011-03-16 Genentech, Inc. Antikörper gegen CD22 für die Behandlung von hämatopoetischen Tumoren
EP2161283A1 (de) 2003-11-17 2010-03-10 Genentech, Inc. Zusammensetzungen, die Antikörper gegen CD79b enthalten, die an Wachstumshemmer oder an zytotoxische Subtanzen gekoppelt sind und Verfahren zur Behandlung von Tumoren hämatopoetischen Ursprungs
US8759305B2 (en) 2004-09-01 2014-06-24 Dynavax Technologies Corporation Methods and compositions for inhibition of innate immune responses and autoimmunity
WO2006028742A2 (en) 2004-09-01 2006-03-16 Dynavax Technologies Corporation Methods and conpositions for inhibition of innate immune responses and autoimmunity
EP2305693A1 (de) 2004-09-01 2011-04-06 Dynavax Technologies Corporation Methoden und Zusammensetzungen zur Hemmung von angeborener Immunität und Autoimmunität
EP2050763A2 (de) 2005-03-10 2009-04-22 Genentech, Inc. Verfahren und Zusammensetzungen zur Modulation der Gefäßintegrität
US9168286B2 (en) 2005-10-13 2015-10-27 Human Genome Sciences, Inc. Methods and compositions for use in treatment of patients with autoantibody positive disease
US8211649B2 (en) 2006-03-31 2012-07-03 Human Genome Sciences, Inc. Methods of diagnosing and prognosing hodgkin's lymphoma
EP2614839A2 (de) 2006-04-05 2013-07-17 Genentech, Inc. Verfahren zur Verwendung von BOC/CDO zur Modulation der Hedgehog-Signalisierung
EP2520935A2 (de) 2006-08-09 2012-11-07 Homestead Clinical Corporation Organspezifische Proteine und Verfahren zu deren Verwendung
WO2008021290A2 (en) 2006-08-09 2008-02-21 Homestead Clinical Corporation Organ-specific proteins and methods of their use
EP2354254A1 (de) 2006-09-06 2011-08-10 Ortho-McNeil Pharmaceutical, Inc. Biomarker zur Überprüfung der Reaktion auf eine C-Met-Behandlung
WO2008032833A1 (fr) 2006-09-14 2008-03-20 Medical & Biological Laboratories Co., Ltd. Anticorps présentant une activité adcc accrue et son procédé de production
EP2450050A1 (de) 2006-11-29 2012-05-09 Genentech, Inc. Heterodimere IL-17A/F-Polypeptide und ihre therapeutische Verwendung
EP3181147A1 (de) 2006-11-29 2017-06-21 Genentech, Inc. Heterodimere il-17a/f-polypeptide und therapeutkum damit
WO2008103962A2 (en) 2007-02-22 2008-08-28 Genentech, Inc. Methods for detecting inflammatory bowel disease
EP2436781A1 (de) 2007-02-22 2012-04-04 Genentech, Inc. Verfahren für den Nachweis von entzündlicher Darmerkrankung
EP2361980A1 (de) 2007-10-26 2011-08-31 Dynavax Technologies Corporation Verfahren und Zusammensetzungen zur Hemmung von Immunantworten und Autoimmunität
US9476053B2 (en) 2007-10-26 2016-10-25 Dynavax Technologies Corporation Methods and compositions for inhibition of immune responses and autoimmunity
US8962579B2 (en) 2007-10-26 2015-02-24 Dynavax Technologies Corporation Methods and compositions for inhibition of immune responses and autoimmunity
EP2599793A1 (de) 2008-05-29 2013-06-05 Nuclea Biotechnologies, Inc. Anti-Phosphor-AKT-Antikörper
US8575314B2 (en) 2008-06-20 2013-11-05 National University Corporation Okayama University Antibody against oxidized LDL/β2GPI complex and use of the same
WO2009154025A1 (ja) 2008-06-20 2009-12-23 国立大学法人岡山大学 酸化LDL/β2GPI複合体に対する抗体及びその用途
US9182406B2 (en) 2008-08-04 2015-11-10 Biodesy, Inc. Nonlinear optical detection of molecules comprising an unnatural amino acid possessing a hyperpolarizability
US9880172B2 (en) 2008-08-04 2018-01-30 Biodesy, Inc. Nonlinear optical detection of molecules comprising an unnatural amino acid possessing a hyperpolarizability
WO2011050194A1 (en) 2009-10-22 2011-04-28 Genentech, Inc. Methods and compositions for modulating hepsin activation of macrophage-stimulating protein
WO2011066503A2 (en) 2009-11-30 2011-06-03 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
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WO2011106297A2 (en) 2010-02-23 2011-09-01 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
WO2011139985A1 (en) 2010-05-03 2011-11-10 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
US9347064B2 (en) 2010-06-16 2016-05-24 Dynavax Technologies Corporation Methods of treatment using TLR7 and/or TLR9 inhibitors
WO2011159958A2 (en) 2010-06-16 2011-12-22 Dynavax Technologies Corporation Methods of treatment using tlr7 and/or tlr9 inhibitors
US8940310B2 (en) 2010-06-16 2015-01-27 Dynavax Technologies Corporation Methods of treatment using TLR7 and/or TLR9 inhibitors
US9428789B2 (en) 2011-03-21 2016-08-30 Biodesy, Inc. Classification of kinase inhibitors using nonlinear optical techniques
WO2013040433A1 (en) 2011-09-15 2013-03-21 Genentech, Inc. Methods of promoting differentiation
WO2013056148A2 (en) 2011-10-15 2013-04-18 Genentech, Inc. Methods of using scd1 antagonists
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WO2013120056A1 (en) 2012-02-11 2013-08-15 Genentech, Inc. R-spondin translocations and methods using the same
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WO2014151006A2 (en) 2013-03-15 2014-09-25 Genentech, Inc. Biomarkers and methods of treating pd-1 and pd-l1 related conditions
WO2015116902A1 (en) 2014-01-31 2015-08-06 Genentech, Inc. G-protein coupled receptors in hedgehog signaling
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US10562946B2 (en) 2014-06-20 2020-02-18 Genentech, Inc. Chagasin-based scaffold compositions, methods, and uses
US10768174B2 (en) 2014-12-23 2020-09-08 Bluelight Therapeutics, Inc. Attachment of proteins to interfaces for use in nonlinear optical detection
WO2018049275A1 (en) 2016-09-09 2018-03-15 Genentech, Inc. Selective peptide inhibitors of frizzled
WO2018152496A1 (en) 2017-02-17 2018-08-23 The Usa, As Represented By The Secretary, Dept. Of Health And Human Services Compositions and methods for the diagnosis and treatment of zika virus infection
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CN112480209A (zh) * 2020-11-16 2021-03-12 昆明学院 一种抗皮肤光损伤保护活性多肽rl-pl9及其应用

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EP0954531A1 (de) 1999-11-10
AU734638B2 (en) 2001-06-21
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