WO1997039122A3 - PHOSPHOPROTEINE DE 78 kDa ISOLEE ET CLONEE DE MASTOCYTES (AGENT INHIBITEUR DE LA DEGRANULATION DES MASTOCYTES) ET SON UTILISATION - Google Patents

PHOSPHOPROTEINE DE 78 kDa ISOLEE ET CLONEE DE MASTOCYTES (AGENT INHIBITEUR DE LA DEGRANULATION DES MASTOCYTES) ET SON UTILISATION Download PDF

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Publication number
WO1997039122A3
WO1997039122A3 PCT/US1997/006042 US9706042W WO9739122A3 WO 1997039122 A3 WO1997039122 A3 WO 1997039122A3 US 9706042 W US9706042 W US 9706042W WO 9739122 A3 WO9739122 A3 WO 9739122A3
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WO
WIPO (PCT)
Prior art keywords
mast cell
moesin
protein
mast
cell degranulation
Prior art date
Application number
PCT/US1997/006042
Other languages
English (en)
Other versions
WO1997039122A2 (fr
WO1997039122A9 (fr
Inventor
Theoharis C Theoharides
Original Assignee
Muro Pharmaceutical Inc
Theoharis C Theoharides
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Muro Pharmaceutical Inc, Theoharis C Theoharides filed Critical Muro Pharmaceutical Inc
Priority to AU24563/97A priority Critical patent/AU2456397A/en
Publication of WO1997039122A2 publication Critical patent/WO1997039122A2/fr
Publication of WO1997039122A3 publication Critical patent/WO1997039122A3/fr
Publication of WO1997039122A9 publication Critical patent/WO1997039122A9/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

On a cloné une protéine de mastocyte de 78 kDa (moesine) depuis le rat et on a déterminé son ADNc et sa séquence d'acides aminés. Cette protéine est phosphorylée sur des résidus spécifiques de serine et de threonine sous l'effet exercé dans les mastocytes par un ou plusieurs isozymes de protéine kinase C, en particulier, l'isozyme κ, ce qui permet d'obtenir une phosphoprotéine qui inhibe la dégranulation des mastocytes (agent inhibiteur de la dégranulation des mastocytes). On peut stimuler la phosphorylation in vivo de cette protéine dans les mastocytes au moyen de médicaments, tels que cromolyne, nedocromil, de flavonoïdes, tels que quercetine et kaempherol, et de lodoxamide, On peut inhiber la dégranulation des mastocytes au moyen de l'administration d'inhibiteurs de phosphomoesine phosphatase. On peut identifier des tissus déficients en moesine de mastocytes au moyen d'un anticorps marqué anti-moesine ou anti-phosphomoesine et les traiter au moyen de la transfection de ces mastocytes par de l'ADNc de moesine dans un vecteur viral, tel que le vecteur du virus de la grippe.
PCT/US1997/006042 1996-04-12 1997-04-11 PHOSPHOPROTEINE DE 78 kDa ISOLEE ET CLONEE DE MASTOCYTES (AGENT INHIBITEUR DE LA DEGRANULATION DES MASTOCYTES) ET SON UTILISATION WO1997039122A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU24563/97A AU2456397A (en) 1996-04-12 1997-04-11 Isolated and cloned mast cell 78 kda phosphoprotein (mast cell degranulation inhibitory agent) and use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63118496A 1996-04-12 1996-04-12
US08/631,184 1996-04-12

Publications (3)

Publication Number Publication Date
WO1997039122A2 WO1997039122A2 (fr) 1997-10-23
WO1997039122A3 true WO1997039122A3 (fr) 1997-12-24
WO1997039122A9 WO1997039122A9 (fr) 1998-03-26

Family

ID=24530125

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/006042 WO1997039122A2 (fr) 1996-04-12 1997-04-11 PHOSPHOPROTEINE DE 78 kDa ISOLEE ET CLONEE DE MASTOCYTES (AGENT INHIBITEUR DE LA DEGRANULATION DES MASTOCYTES) ET SON UTILISATION

Country Status (2)

Country Link
AU (1) AU2456397A (fr)
WO (1) WO1997039122A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6280739B1 (en) * 1996-04-18 2001-08-28 Genetics Institute, Inc. Method of inhibiting angiogenesis using secreted proteins
US5872234A (en) 1997-06-27 1999-02-16 Incyte Pharmaceuticals, Inc. Human extracellular matrix proteins
EP1557426A3 (fr) * 1998-02-09 2005-08-03 Human Genome Sciences, Inc. 45 Protéines humaines secrétées
KR20010043090A (ko) * 1998-04-28 2001-05-25 우에노 도시오 신규인 폴리펩티드, 그 폴리펩티드를 코드화하는 ｃＤＮＡ및 그 용도
US8410248B2 (en) 1999-03-12 2013-04-02 Human Genome Sciences Inc. HWBAO62 polypeptides
MXPA01012181A (es) * 1999-05-28 2002-07-22 Zymogenetics Inc Proteina-31 alfa-helicoidal secretada.
US7893218B2 (en) * 2003-06-16 2011-02-22 Stowers Institute For Medical Research Antibodies that specifically bind SOST peptides

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0613945A2 (fr) * 1993-02-25 1994-09-07 The General Hospital Corporation Merlin, gène suppresseur de tumeurs, et ses utilisations

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0613945A2 (fr) * 1993-02-25 1994-09-07 The General Hospital Corporation Merlin, gène suppresseur de tumeurs, et ses utilisations

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
LANKES WT ET AL: "Moesin: a member of the protein 4.1-talin-ezrin family of proteins.", PROC NATL ACAD SCI U S A, OCT 1 1991, 88 (19) P8297-301, UNITED STATES, XP002045604 *
NAKAMURA F ET AL: "Phosphorylation of threonine 558 in the carboxyl-terminal actin-binding domain of moesin by thrombin activation of human platelets.", J BIOL CHEM, DEC 29 1995, 270 (52) P31377-85, UNITED STATES, XP002045605 *
SATO N ET AL: "A gene family consisting of ezrin, radixin and moesin. Its specific localization at actin filament/plasma membrane association sites.", J CELL SCI, SEP 1992, 103 ( PT 1) P131-43, ENGLAND, XP002045603 *
SCHWARTZ-ALBIEZ R ET AL: "Differential expression of the microspike-associated protein moesin in human tissues.", EUR J CELL BIOL, JUL 1995, 67 (3) P189-98, GERMANY, XP002045606 *

Also Published As

Publication number Publication date
WO1997039122A2 (fr) 1997-10-23
AU2456397A (en) 1997-11-07

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