AU636148B2 - Human leukocyte elastase inhibitors - Google Patents

Human leukocyte elastase inhibitors

Info

Publication number
AU636148B2
AU636148B2 AU56808/90A AU5680890A AU636148B2 AU 636148 B2 AU636148 B2 AU 636148B2 AU 56808/90 A AU56808/90 A AU 56808/90A AU 5680890 A AU5680890 A AU 5680890A AU 636148 B2 AU636148 B2 AU 636148B2
Authority
AU
Australia
Prior art keywords
pro
cys
lys
gly
ile
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU56808/90A
Other versions
AU5680890A (en
Inventor
Enno Christophers
Michael Derek Edge
David Pioli
Jens-Michael Schroder
Oliver Wiedow
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wiedow Oliver Professor
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898913346A external-priority patent/GB8913346D0/en
Priority claimed from GB898913349A external-priority patent/GB8913349D0/en
Priority claimed from GB898921613A external-priority patent/GB8921613D0/en
Priority claimed from GB898924717A external-priority patent/GB8924717D0/en
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Publication of AU5680890A publication Critical patent/AU5680890A/en
Publication of AU636148B2 publication Critical patent/AU636148B2/en
Application granted granted Critical
Assigned to ZENECA LIMITED reassignment ZENECA LIMITED Alteration of Name(s) in Register under S187 Assignors: IMPERIAL CHEMICAL INDUSTRIES PLC
Assigned to ASTRAZENECA AB reassignment ASTRAZENECA AB Alteration of Name(s) in Register under S187 Assignors: ZENECA LIMITED
Assigned to Wiedow, Oliver Professor reassignment Wiedow, Oliver Professor Alteration of Name(s) in Register under S187 Assignors: ASTRAZENECA AB
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Polypeptides, in particular the polypeptide of formula I: Ala-Gln-Glu-Pro-Val-Lys-Gly-Pro-Val-Ser-Thr-Lys-Pro-Gly-Ser-Cys-Pro-Il e-Ile-Leu- Ile-Arg-Cys-Ala-Met-Leu-Asn-Pro-Pro-Asn-Arg-Cys-Leu-Lys-Asp-Thr-Asp-Cy s-Pro-Gly- Ile-Lys-Lys-Cys-Cys-Glu-Gly-Ser-Cys-Gly-Met-Ala-Cys-Phe-Val-Pro-Gln and analogues thereof which possess inhibitory activity against human leukocyte elastase. The polypeptides may be obtained by expression using plasmidic expression systems in hosts such as E. Coli and yeast, the polypeptide of formula I being also obtainable from psoriatic plaques.
AU56808/90A 1989-06-09 1990-06-05 Human leukocyte elastase inhibitors Expired AU636148B2 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
GB898913346A GB8913346D0 (en) 1989-06-09 1989-06-09 Polypeptide analogues
GB8913349 1989-06-09
GB898913349A GB8913349D0 (en) 1989-06-09 1989-06-09 Polypeptides
GB8913346 1989-06-09
GB8921613 1989-09-25
GB898921613A GB8921613D0 (en) 1989-09-25 1989-09-25 Polypeptides-1st update
GB8924717 1989-11-02
GB898924717A GB8924717D0 (en) 1989-11-02 1989-11-02 Polypeptides

Publications (2)

Publication Number Publication Date
AU5680890A AU5680890A (en) 1990-12-13
AU636148B2 true AU636148B2 (en) 1993-04-22

Family

ID=27450350

Family Applications (1)

Application Number Title Priority Date Filing Date
AU56808/90A Expired AU636148B2 (en) 1989-06-09 1990-06-05 Human leukocyte elastase inhibitors

Country Status (16)

Country Link
US (4) US5464822A (en)
EP (1) EP0402068B1 (en)
JP (1) JP2989853B2 (en)
AT (1) ATE131493T1 (en)
AU (1) AU636148B2 (en)
CA (1) CA2018592C (en)
DE (1) DE69024104T2 (en)
DK (1) DK0402068T3 (en)
ES (1) ES2080800T3 (en)
FI (1) FI106471B (en)
GR (1) GR3018401T3 (en)
IE (1) IE70520B1 (en)
IL (1) IL94602A (en)
NO (1) NO177716C (en)
NZ (1) NZ233974A (en)
PT (1) PT94326B (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO177716C (en) * 1989-06-09 1995-11-08 Zeneca Ltd Method for Preparation of Therapeutically Active Polypeptides, DNA Sequence, Expression Vector and Antibody
EP0458537B1 (en) * 1990-05-24 1999-03-31 Zeneca Limited Use of a therapeutic compound for the treatment of bronchitis
DE69129083T2 (en) * 1990-05-24 1998-07-09 Zeneca Ltd Therapeutic agent for the prevention and treatment of respiratory distress syndrome in adults
US5162348A (en) * 1990-05-24 1992-11-10 Imperial Chemical Industries Plc Treatment of cystic fibrosis
US5734014A (en) * 1992-08-11 1998-03-31 Tsumura & Co. Elafin derivative
US8606851B2 (en) 1995-06-06 2013-12-10 Wayport, Inc. Method and apparatus for geographic-based communications service
US5835061A (en) 1995-06-06 1998-11-10 Wayport, Inc. Method and apparatus for geographic-based communications service
EP0834556A1 (en) * 1996-09-25 1998-04-08 Academisch Ziekenhuis Leiden Methods for culturing cells
US7034132B2 (en) 2001-06-04 2006-04-25 Anderson David W Therapeutic polypeptides, nucleic acids encoding same, and methods of use
AU2001241913A1 (en) * 2000-03-01 2001-09-12 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods for wound treatment
US7247704B2 (en) 2000-12-18 2007-07-24 Arriva Pharmaceuticals, Inc. Multifunctional protease inhibitors and their use in treatment of disease
US6600057B2 (en) 2000-12-29 2003-07-29 Kimberly-Clark Worldwide, Inc. Matrix metalloproteinase inhibitors
US7041787B2 (en) * 2000-12-29 2006-05-09 Kimberly-Clark Worldwide, Inc. Design and use of advanced zinc chelating peptides to regulate matrix metalloproteinases
US20030119073A1 (en) * 2001-12-21 2003-06-26 Stephen Quirk Sensors and methods of detection for proteinase enzymes
US20030170617A1 (en) 2002-01-28 2003-09-11 Pasloske Brittan L. Crude biological derivatives competent for nucleic acid detection
JP4651946B2 (en) * 2002-04-25 2011-03-16 ザ スクリプス リサーチ インスティテュート Treatment and prevention of pulmonary conditions
FR2849375B1 (en) * 2002-12-30 2006-10-20 Jean Noel Thorel COSMETIC COMPOSITIONS, FOR EXAMPLE FOR TREATING SKIN-INDUCED CUTANE AGING
WO2004098626A2 (en) * 2003-05-07 2004-11-18 Vib Vzw The use of a polypeptide domain of slpi to modulate the tumorigenic and metastatic potential of cancer cells
WO2006122404A1 (en) * 2005-05-16 2006-11-23 Her Majesty The Queen In Right As Represented By The Minister Of Health Trappin-2 (elafin) inhibits hiv
US7964350B1 (en) 2007-05-18 2011-06-21 Applied Biosystems, Llc Sample preparation for in situ nucleic acid analysis
EP2367954B1 (en) * 2008-12-19 2015-02-18 Life Technologies Corporation Proteinase k inhibitors, methods and compositions therefor
GB201003559D0 (en) 2010-03-03 2010-04-21 Proteo Biotech Ag Novel use of elafin
US20230285523A1 (en) * 2021-12-20 2023-09-14 Tiakis Biotech Ag Use of elafin in the treatment of covid-19

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4746729A (en) * 1986-07-30 1988-05-24 Kuettner Klaus E Cartilage-derived leukocyte elastase-inhibitor
US6024983A (en) * 1986-10-24 2000-02-15 Southern Research Institute Composition for delivering bioactive agents for immune response and its preparation
ATE162931T1 (en) * 1989-02-23 1998-02-15 Blood Res Center HUMAN ELASTASE INHIBITOR
NO177716C (en) * 1989-06-09 1995-11-08 Zeneca Ltd Method for Preparation of Therapeutically Active Polypeptides, DNA Sequence, Expression Vector and Antibody

Also Published As

Publication number Publication date
IL94602A (en) 1996-06-18
NO902444D0 (en) 1990-06-01
IE70520B1 (en) 1996-12-11
PT94326A (en) 1991-02-08
NO177716B (en) 1995-07-31
US6893843B2 (en) 2005-05-17
JPH03148299A (en) 1991-06-25
EP0402068A1 (en) 1990-12-12
ES2080800T3 (en) 1996-02-16
US6245739B1 (en) 2001-06-12
DK0402068T3 (en) 1996-04-22
IE902006L (en) 1990-12-09
CA2018592A1 (en) 1990-12-09
NO902444L (en) 1990-12-10
FI902880A0 (en) 1990-06-08
US20060068480A1 (en) 2006-03-30
DE69024104D1 (en) 1996-01-25
PT94326B (en) 1997-01-31
US5464822A (en) 1995-11-07
NO177716C (en) 1995-11-08
GR3018401T3 (en) 1996-03-31
ATE131493T1 (en) 1995-12-15
JP2989853B2 (en) 1999-12-13
CA2018592C (en) 2002-08-27
IL94602A0 (en) 1991-04-15
DE69024104T2 (en) 1996-06-13
EP0402068B1 (en) 1995-12-13
NZ233974A (en) 1993-05-26
FI106471B (en) 2001-02-15
AU5680890A (en) 1990-12-13
US20020187535A1 (en) 2002-12-12

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Owner name: ASTRAZENECA AB

Free format text: FORMER OWNER WAS: ZENECA LIMITED