WO1997037044A9 - Nucleic acid and amino acid sequences relating to helicobacter pylori and vaccine compositions thereof - Google Patents

Abstract

Recombinant or substantially pure preparations of H. pylori polypeptides are described. The nucleic acids encoding the polypeptides also are described. The H. pylori polypeptides are useful in diagnostic and vaccine compositions.

Description

NUCLEIC ACID AND AMINO ACID SEQUENCES RELATING TO HELICOBACTER PYLORI AND VACCINE COMPOSITIONS THEREOF

Background of the Invention Helicobacter pylori is a gram-negative, S-shaped, microaerophilic bacterium that was discovered and cultured from a human gastric biopsy specimen. (Warren. J.R. and B. Marshall, (1983) Lancet 1 : 1273-1275; and Marshall et al., (1984) Microbios Lett. 25: 83-88). H. pylori has been strongly linked to chronic gastritis and duodenal ulcer disease. (Rathbone et. al., (1986) Gut 27: 635-641). Moreover, evidence is accumulating for an etiologic role of H. pylori in nonulcer dyspepsia, gastric ulcer disease, and gastric adenocarcinoma. (Blaser M. J., (1993) Trends Microbiol. 1 : 255- 260). Transmission of the bacteria occurs via the oral route, and the risk of infection increases with age. (Taylor, D.N. and M. J. Blaser, (1991) Epidemiol. Rev J_3: 42-50). H. pylori colonizes the human gastric mucosa, establishing an infection that usually persists for decades. Infection by H. pylori is prevalent worldwide. Developed countries have infection rates over 50% of the adult population, while developing countries have infection rates reaching 90% of the adults over the age of 20. (Hopkins R. J. and J. G. Morris (1994) Am. J. Med. 97: 265-277).

The bacterial factors necessary for colonization of the gastric environment, and for virulence of this pathogen, are poorly understood. Examples of the putative virulence factors include the following: urease, an enzyme that may play a role in neutralizing gastric acid pH (Eaton et al., (1991) Infect. Immunol. 59: 2470-2475; Ferrero, R.L. and A. Lee (1991) Microb. Ecol. Hlth. Dis. 4: 121-134; Labigne et al., (1991) J Bacteriol. 173: 1920-1931); the bacterial flagellar proteins responsible for motility across the mucous layer. (Hazell et al., (1986) J. Inf. Dis. 153: 658-663; Leying et al., (1992) Mol. Microbiol. 6: 2863-2874; and Haas et al., (1993) Mol. Microbiol. 8: 753-760); Vac A, a bacterial toxin that induces the formation of intracellular vacuoles in epithelial cells (Schmitt, W. and R. Haas, (1994) Molecular Microbiol. 12(2): 307-319); and several gastric tissue-specific adhesins. (Boren et al., (1993) Science 262: 1892- 1895; Evans et al., (1993) J. Bacteriol. 175: 674-683; and Falk et al., (1993) Proc. Natl. Acad. Sci. USA 90: 2035-203).

Numerous therapeutic agents are currently available that eradicate H. pylori infections in vitro. (Huesca et. al., (1993) Zbl. Bakt. 280: 244-252; Hopkins, R. J. and J. G. Morris, supra). However, many of these treatments are suboptimally effective in vivo because of bacterial resistance, altered drug distribution, patient non-compliance or poor drug availabilty. (Hopkins, R. J. and J. G. Morris, supra). Treatment with antibiotics combined with bismuth are part of the standard regime used to treat H. pylori infection. (Malfertheiner, P. and J. E. Dominguez-Munoz (1993) Clinical Therapeutics 15_. Supp. B: 37-48). Recently, combinations of a proton pump inhibitors and a single antibiotic have been shown to ameliorate duodenal ulcer disease. (Malfertheiner, P. and J. E. Dominguez-Munoz supra). However, methods employing antibiotic agents can have the problem of the emergence of bacterial strains which are resistant to these agents.

(Hopkins, R. J. and J. G. Morris, supra). These limitations demonstrate that new more effective methods are needed to combat H. pylori infections in vivo. In particular, the design of new vaccines that may prevent infection by this bacterium is highly desirable.

Summary of the Invention

This invention relates to novel genes, e.g., genes encoding polypeptides such as bacterial surface proteins, from the organism Helicobacter pylori (H pylori), and other related genes, their products, and uses thereof. The nucleic acids and peptides of the present invention have utility for diagnostic and therapeutics for H pylori and other Helicobacter species. They can also be used to detect the presence of H. pylori and other Helicobacter species in a sample; and for use in screening compounds for the ability to interfere with the H pylori life cycle or to inhibit H pylori infection. More specifically, this invention features compositions of nucleic acids corresponding to entire coding sequences of H pylori proteins, including surface or secreted proteins or parts thereof, nucleic acids capable of binding mRNA from H pylori proteins to block protein translation, and methods for producing H pylori proteins or parts thereof using peptide synthesis and recombinant DNA techniques. This invention also features antibodies and nucleic acids useful as probes to detect H pylori infection. In addition, vaccine compositions and methods for the protection against infection by H. pylori are within the scope of this invention.

Detailed Description of the Drawings

Figure 1 is a bar graph that depicts the antibody titer in serum of mice following immunization with specific H pylori antigens. Figure 2 is a bar graph that depicts the antibody titer in mucous of mice following immunization with specific H pylori antigens.

Figure 3 is a bar graph that depicts therapeutic immunization of H. pylori infected mice with specific antigens dissolved in HEPES buffer.

Figure 4 is a bar graph that depicts therapeutic immunization of H pylori infected mice with specific antigens dissolved in buffer containing DOC.

Figure 5 is a graph depicting the activity of recombinant PPIase. Figure 6 is a graph depicting PPIase activity in an H. pylori extract. Figure 7 is a graph depicting a decrease of glutamate racemase activity with L- Serine-O-Sulfate.

Figure 8 depicts the amino acid sequence alignment in a portion of the sequence of 12 H. pylori proteins (depicted in the single letter amino acid code and designated by their amino acid Sequence ID Numbers; shown N-terminal to C-terminal, left to right).

Figure 9 depicts the N-terminal portion of nine H pylori proteins (depicted in the single letter amino acid code and designated by their amino acid Sequence ID Numbers; shown N-terminal to C-terminal, left to right).

Detailed Description of the Invention

In one aspect, the invention features a recombinant or substantially pure preparation of H. pylori polypeptide of SEQ ID NO: 492. The invention also includes substantially pure nucleic acid encoding an H. pylori polypeptide of SEQ ID NO: 492, such nucleic acid is contained in SEQ ID NO: 1. The H. pylori polypeptide sequences described herein are contained in the Sequence Listing, and the nucleic acids encoding H pylori polypeptides are contained in the Sequence Listing.

In another aspect, the invention features a recombinant or substantially pure preparation of an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 492 through SEQ ID NO: 541. The invention also includes substantially pure nucleic acid encoding an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides SEQ ID NO: 492 through SEQ ID NO: 541, such nucleic acids are contained in SEQ ID NO: 1 through SEQ ID NO: 50.

In another aspect, the invention features a recombinant or substantially pure preparation of an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 542 through SEQ ID NO: 591. The invention also includes substantially pure nucleic acid encoding an H. pylori polypeptide selected from the group consisting of H pylori polypeptides SEQ ID NO: 542 through SEQ ID NO: 591, such nucleic acids are contained in SEQ ID NO: 51 through SEQ ID NO: 100. In another aspect, the invention features a recombinant or substantially pure preparation of an H pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 592 through SEQ ID NO: 641. The invention also includes substantially pure nucleic acid encoding an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides SEQ ID NO: 592 through SEQ ID NO: 641 , such nucleic acids are contained in SEQ ID NO: 101 through SEQ ID NO: 150. In another aspect, the invention features a recombinant or substantially pure preparation of an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 642 through SEQ ID NO: 691. The invention also includes substantially pure nucleic acid encoding an H pylori polypeptide selected from the group consisting of H pylori polypeptides SEQ ID NO: 642 through SEQ ID NO: 691, such nucleic acids are contained in SEQ ID NO: 151 through SEQ ID NO: 200. In another aspect, the invention features a recombinant or substantially pure preparation of an H pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 692 through SEQ ID NO: 741. The invention also includes substantially pure nucleic acid encoding an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides SEQ ID NO: 692 through SEQ ID NO: 741, such nucleic acids are contained in SEQ ID NO: 201 through SEQ ID NO: 250. In another aspect, the invention features a recombinant or substantially pure preparation of an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 742 through SEQ ID NO: 759, SEQ ID NO: 761, SEQ ID NO: 763, SEQ ID NO: 765 through SEQ ID NO: 791. The invention also includes substantially pure nucleic acid encoding an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides SEQ ID NO: 742 through SEQ ID NO: 759, SEQ ID NO: 761, SEQ ID NO: 763, SEQ ID NO: 765 through SEQ ID NO: 791, such nucleic acids are contained in SEQ ID NO: 251 through SEQ ID NO: 268, SEQ ID NO: 270, SEQ ID NO: 272, and SEQ ID NO: 274 through SEQ ID NO: 300.

In another aspect, the invention features a recombinant or substantially pure preparation of an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 792 through SEQ ID NO: 818 and SEQ ID NO: 820 through SEQ ID NO: 841. The invention also includes substantially pure nucleic acid encoding an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides SEQ ID NO: 792 through SEQ ID NO: 818 and SEQ ID NO: 820 through SEQ ID NO: 841, such nucleic acids are contained in SEQ ID NO: 301 through SEQ ID NO: 327 and SEQ ID NO: 329 throgh SEQ ID NO: 350. In another aspect, the invention features a recombinant or substantially pure preparation of an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 842 through SEQ ID NO: 846 and SEQ ID NO: 848 through SEQ ID NO: 891. The invention also includes substantially pure nucleic acid encoding an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides SEQ ID NO: 842 through SEQ ID NO: 846 and SEQ ID NO: 848 through SEQ ID NO: 891, such nucleic acids are contained in SEQ ID NO: 351 through SEQ ID NO: 364 and SEQ ID NO: 366 through SEQ ID NO: 400.

In another aspect, the invention features a recombinant or substantially pure preparation of an H. pylori polypeptide selected from the group consisting of//, pylori polypeptides of SEQ ID NO: 892 through SEQ ID NO: 896 and SEQ ID NO: 898 through SEQ ID NO: 941. The invention also includes substantially pure nucleic acid encoding an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides SEQ ID NO: 892 through SEQ ID NO: 896 and SEQ ID NO: 898 through SEQ ID NO: 941, such nucleic acids are contained in SEQ ID NO: 401 through SEQ ID NO: 405 and SEQ ID NO: 407 through SEQ ID NO: 450.

In another aspect, the invention features a recombinant or substantially pure preparation of an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 942 through SEQ ID NO: 963 and SEQ ID NO: 966 through SEQ ID NO: 982. The invention also includes substantially pure nucleic acid encoding an H pylori polypeptide selected from the group consisting of H. pylori polypeptides SEQ ID NO: 942 through SEQ ID NO: 963 and SEQ ID NO: 966 through SEQ ID NO: 982, such nucleic acids are contained in SEQ ID NO: 451 through SEQ ID NO: 472 and SEQ ID NO: 475 through SEQ ID NO: 491.

In another aspect, the invention features a recombinant or substantially pure preparation of an H. pylori polypeptide selected from the group consisting of H pylori polypeptides of SEQ ID NO: 1037, SEQ ID NO: 1038, SEQ ID NO: 1041 through SEQ ID NO: 1087 and SEQ ID NO: 1090. The invention also includes substantially pure nucleic acid encoding an H. pylori polypeptide selected from the group consisting of H pylori polypeptides SEQ ID NO: 1037, SEQ ID NO: 1038, SEQ ID NO: 1041 through SEQ ID NO: 1087 and SEQ ID NO: 1090, such nucleic acids are contained in SEQ ID NO: 983, SEQ ID NO: 984, SEQ ID NO: 987 through SEQ ID NO: 1033 and SEQ ID NO: 1036.

In another aspect, the invention features a recombinant or substantially pure preparation of an H pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 1296 through SEQ ID NO: 1298. The invention also includes substantially pure nucleic acid encoding an H. pylori polypeptide selected from the group consisting of H pylori polypeptides SEQ ID NO: 1296 through SEQ ID NO: 1298, such nucleic acids are contained in SEQ ID NO: 1293 through SEQ ID NO: 1295. In another aspect, the invention features a recombinant or substantially pure preparation of an H. pylori polypeptide selected from the group consisting of// pylori polypeptides as set forth in the Sequence Listing. The invention also includes substantially pure nucleic acid encoding an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides as set forth in the Sequence Listing. It should be understood that this invention encompasses each of the H. pylori polypeptides and nucleic acids encoding such polypeptides as identified in the Sequence Listing by a given sequence identification number. For example, a representative H. pylori polypeptide is contained in SEQ ID NO: 494. Therefore, this invention encompasses a recombinant or substantially pure preparation of an H. pylori polypeptide of SEQ ID NO: 494. The invention also includes substantially pure nucleic acid encoding an H. pylori polypeptide of SEQ ID NO: 494. In another aspect, the invention pertains to any individual H. pylori polypeptide member or nucleic acid encoding such member from the above-identified groups of H. pylori polypeptides (e.g., SEQ ID NO: 542-SEQ ID NO: 591) or nucleic acids (e.g., SEQ ID NO: 51 -SEQ ID NO: 100), as well as any subgroups from within the above- identified groups. Furthermore, the subgroups can preferably consists of 1, 3, 5, 10, 15, 20, 30 or 40 members of any of the groups identified above, as well as, any combinations thereof. For example, the group consisting of H. pylori polypeptides SEQ ID NO: 692 through SEQ ID NO: 741 can be divided into one or more subgroups as follows: SEQ ID NO: 692-SEQ ID NO: 680; SEQ ID NO: 681-SEQ ID NO: 710; SEQ ID NO: 711-SEQ ID NO: 730; SEQ ID NO: 731-SEQ ID NO: 741 ; or any combinations thereof.

Particularly preferred is an isolated nucleic acid comprising a nucleotide sequence encoding an H. pylori cell envelope polypeptide or a fragment thereof. Such nucleic acid is selected from the group consisting of SEQ ID NO: 255, SEQ ID NO: 263, SEQ ID NO: 266, SEQ ID NO: 277, SEQ ID NO: 280, SEQ ID NO: 285, SEQ ID NO: 292, SEQ ID NO: 294, SEQ ID NO: 299, SEQ ID NO: 311, SEQ ID NO: 312, SEQ ID NO: 313, SEQ ID NO: 321, SEQ ID NO: 327, SEQ ID NO: 329, SEQ ID NO: 331, SEQ ID NO: 353, SEQ ID NO: 364, SEQ ID NO: 366, SEQ ID NO: 368, SEQ ID NO: 375, SEQ ID NO: 384, SEQ ID NO: 391, SEQ ID NO: 392, SEQ ID NO: 397, SEQ ID NO: 398, SEQ ID NO: 402, SEQ ID NO: 404, SEQ ID NO: 409, SEQ ID NO: 410, SEQ ID NO: 412, SEQ ID NO: 427, SEQ ID NO: 433, SEQ ID NO: 434, SEQ ID NO: 441, SEQ ID NO: 444, SEQ ID NO: 445, SEQ ID NO: 449, SEQ ID NO: 450, SEQ ID NO: 452, SEQ ID NO: 453, SEQ ID NO: 466, SEQ ID NO: 468, SEQ ID NO: 469, SEQ ID NO: 983, SEQ ID NO: 989, SEQ ID NO: 1008, SEQ ID NO: 1011, SEQ ID NO: 1014, SEQ ID NO: 1015, SEQ ID NO: 1029, SEQ ID NO: 1032, SEQ ID NO: 259, SEQ ID NO: 286, SEQ ID NO: 326, SEQ ID NO: 374, SEQ ID NO: 399, SEQ ID NO: 422, SEQ ID NO: 454, SEQ ID NO: 465, SEQ ID NO: 998, SEQ ID NO: 1009, SEQ ID NO: 1023, SEQ ID NO: 1294, SEQ ID NO: 1295, SEQ ID NO: 319, SEQ ID NO: 325, SEQ ID NO: 425, SEQ ID NO: 437, SEQ ID NO: 438, SEQ ID NO: 447, SEQ ID NO: 448, SEQ ID NO: 467, SEQ ID NO: 996, SEQ ID NO: 1027, SEQ ID NO: 1031, SEQ ID NO: 254, SEQ ID NO: 352, SEQ ID NO: 415, SEQ ID NO: 1019, SEQ ID NO: 381, SEQ ID NO: 389, SEQ ID NO: 1010, SEQ ID NO: 1012, SEQ ID NO: 354, SEQ ID NO: 372, SEQ ID NO: 400, SEQ ID NO: 421, SEQ ID NO: 1022, SEQ ID NO: 463, SEQ ID NO: 281, SEQ ID NO: 988, SEQ ID NO: 411, SEQ ID NO: 407, SEQ ID NO: 1017, SEQ ID NO: 290, SEQ ID NO: 417, SEQ ID NO: 430, SEQ ID NO: 992, SEQ ID NO: 1025, SEQ ID NO: 477, SEQ ID NO: 414, SEQ ID NO: 253, SEQ ID NO: 293, SEQ ID NO: 334, SEQ ID NO: 343, SEQ ID NO: 418, SEQ ID NO: 424, and SEQ ID NO: 443.

In another embodiment, the H. pylori cell envelope polypeptide or a fragment thereof is an H. pylori outer membrane polypeptide or a fragment thereof encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 255, SEQ ID NO: 263, SEQ ID NO: 266, SEQ ID NO: 277, SEQ ID NO: 280, SEQ ID NO: 285, SEQ ID NO: 292, SEQ ID NO: 294, SEQ ID NO: 299, SEQ ID NO: 311, SEQ ID NO: 312, SEQ ID NO: 313, SEQ ID NO: 321, SEQ ID NO: 327, SEQ ID NO: 329, SEQ ID NO: 331, SEQ ID NO: 353, SEQ ID NO: 364, SEQ ID NO: 366, SEQ ID NO: 368, SEQ ID NO: 375, SEQ ID NO: 384, SEQ ID NO: 391, SEQ ID NO: 392, SEQ ID NO: 397, SEQ ID NO: 398, SEQ ID NO: 402, SEQ ID NO: 404, SEQ ID NO: 409, SEQ ID NO: 410, SEQ ID NO: 412, SEQ ID NO: 427, SEQ ID NO: 433, SEQ ID NO: 434, SEQ ID NO: 441, SEQ ID NO: 444, SEQ ID NO: 445, SEQ ID NO: 449, SEQ ID NO: 450, SEQ ID NO: 452, SEQ ID NO: 453, SEQ ID NO: 466, SEQ ID NO: 468, SEQ ID NO: 469, SEQ ID NO: 983, SEQ ID NO: 989, SEQ ID NO: 1008, SEQ ID NO: 1011, SEQ ID NO: 1014, SEQ ID NO: 1015, SEQ ID NO: 1029, SEQ ID NO: 1032, SEQ ID NO: 259, SEQ ID NO: 286, SEQ ID NO: 326, SEQ ID NO: 374, SEQ ID NO: 399, SEQ ID NO: 422, SEQ ID NO: 454, SEQ ID NO: 465, SEQ ID NO: 998, SEQ ID NO: 1009, SEQ ID NO: 1023, SEQ ID NO: 1294, SEQ ID NO: 1295, SEQ ID NO: 319, SEQ ID NO: 325, SEQ ID NO: 425, SEQ ID NO: 437, SEQ ID NO: 438, SEQ ID NO: 447, SEQ ID NO: 448, SEQ ID NO: 467, SEQ ID NO: 996, SEQ ID NO: 1027, SEQ ID NO: 1031, SEQ ID NO:

254, SEQ ID NO: 352, SEQ ID NO: 415, SEQ ID NO: 1019, SEQ ID NO: 381, SEQ ID NO: 389, SEQ ID NO: 1010, and SEQ ID NO: 1012.

In another embodiment, the H. pylori outer membrane polypeptide or a fragment thereof is an H. pylori polypeptide having a terminal phenylalanine residue or a fragment thereof encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 255, SEQ ID NO: 263, SEQ ID NO: 266, SEQ ID NO: 277, SEQ ID NO: 280, SEQ ID NO: 285, SEQ ID NO: 292, SEQ ID NO: 294, SEQ ID NO: 299, SEQ ID NO: 311, SEQ ID NO: 312, SEQ ID NO: 313, SEQ ID NO: 321, SEQ ID NO: 327, SEQ ID NO: 329, SEQ ID NO: 331, SEQ ID NO: 353, SEQ ID NO: 364, SEQ ID NO: 366, SEQ ID NO: 368, SEQ ID NO: 375, SEQ ID NO: 384, SEQ ID NO: 391, SEQ ID NO: 392, SEQ ID NO: 397, SEQ ID NO: 398, SEQ ID NO: 402, SEQ ID NO: 404, SEQ ID NO: 409, SEQ ID NO: 410, SEQ ID NO: 412, SEQ ID NO: 427, SEQ ID NO: 433, SEQ ID NO: 434, SEQ ID NO: 441, SEQ ID NO: 444, SEQ ID NO: 445, SEQ ID NO: 449, SEQ ID NO: 450, SEQ ID NO: 452, SEQ ID NO: 453, SEQ ID NO: 466, SEQ ID NO: 468, SEQ ID NO: 469, SEQ ID NO: 983, SEQ ID NO: 989, SEQ ID NO: 1008, SEQ ID NO: 1011, SEQ ID NO: 1014, SEQ ID NO: 1015, SEQ ID NO: 1029, and SEQ ID NO: 1032. In another embodiment, the H. pylori outer membrane polypeptide or a fragment thereof is an H. pylori polypeptide having a C-terminal tyrosine cluster or a fragment thereof encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 286, SEQ ID NO: 326, SEQ ID NO: 374, SEQ ID NO: 399, SEQ ID NO: 422, SEQ ID NO: 454, SEQ ID NO: 465, SEQ ID NO: 998, SEQ ID NO: 1009, SEQ ID NO: 1023, SEQ ID NO: 1294, and SEQ ID NO: 1295.

In another embodiment, the H. pylori outer membrane polypeptide or a fragment thereof is an H. pylori polypeptide having a terminal phenylalanine residue and a C- terminal tyrosine cluster or a fragment thereof encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 319, SEQ ID NO: 325, SEQ ID NO: 425, SEQ ID NO: 437, SEQ ID NO: 438, SEQ ID NO: 447, SEQ ID NO: 448, SEQ ID NO: 467, SEQ ID NO: 996, SEQ ID NO: 1027, and SEQ ID NO: 1031.

In another embodiment, the H pylori cell envelope polypeptide or a fragment thereof is an H. pylori inner membrane polypeptide or a fragment thereof encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 354, SEQ ID NO: 372, SEQ ID NO: 400, SEQ ID NO: 421, SEQ ID NO: 1022, SEQ ID NO: 463, SEQ ID NO: 281, SEQ ID NO: 988, SEQ ID NO: 411, SEQ ID NO: 407, SEQ ID NO: 1017, SEQ ID NO: 290, SEQ ID NO: 417, SEQ ID NO: 430, SEQ ID NO: 992, and SEQ ID NO: 1025. In another embodiment, the H. pylori inner membrane polypeptide or a fragment thereof is an H. pylori polypeptide involved in outer membrane and cell wall synthesis or a fragment thereof encoded by the nucleic acid comprising a nucleotide sequence of SEQ ID NO: 354.

In another embodiment, the H. pylori inner membrane polypeptide or a fragment thereof is an H. pylori polypeptide involved in energy conversion or a fragment thereof encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 372, SEQ ID NO: 400, SEQ ID NO: 421, and SEQ ID NO: 1022. In another embodiment, the H. pylori inner membrane polypeptide or a fragment thereof is an H. pylori polypeptide involved in cofactor metabolism or a fragment thereof encoded by the nucleic acid comprising a nucleotide sequence of SEQ ID NO: 463. In another embodiment, the H. pylori inner membrane polypeptide or a fragment thereof is an H. pylori polypeptide involved in secretion or adhesion or a fragment thereof encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 281 and SEQ ID NO: 988.

In another embodiment, the H pylori inner membrane polypeptide or a fragment thereof is an H. pylori polypeptide involved in transport or a fragment thereof encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 407 and SEQ ID NO: 1017.

In another embodiment, the H. pylori cell envelope polypeptide or a fragment thereof is an H. pylori flagellar polypeptide or a fragment thereof encoded by the nucleic acid comprising a nucleotide sequence of SEQ ID NO: 477. In another embodiment, the H. pylori cell envelope polypeptide or a fragment thereof is an H. pylori transport polypeptide or a fragment thereof encoded by the nucleic acid comprising a nucleotide sequence of SEQ ID NO: 414.

Particularly preferred is an isolated nucleic acid comprising a nucleotide sequence encoding an H. pylori cytoplasmic polypeptide or a fragment thereof. Such nucleic acid is selected from the group consisting of SEQ ID NO: 470, SEQ ID NO: 1033, SEQ ID NO: 357, SEQ ID NO: 457, SEQ ID NO: 461, SEQ ID NO: 1030, SEQ ID NO: 345, SEQ ID NO: 383, SEQ ID NO: 387, SEQ ID NO: 455, SEQ ID NO: 1003, SEQ ID NO: 351, SEQ ID NO: 416, SEQ ID NO: 278, SEQ ID NO: 335, SEQ ID NO: 346, SEQ ID NO: 350, SEQ ID NO: 419, SEQ ID NO: 460, SEQ ID NO: 472, SEQ ID NO: 1000, SEQ ID NO: 1004, SEQ ID NO: 1020, SEQ ID NO: 1293, SEQ ID NO: 318, SEQ ID NO: 322, SEQ ID NO: 324, SEQ ID NO: 330, SEQ ID NO: 347, SEQ ID NO: 440, SEQ ID NO: 446, SEQ ID NO: 464, SEQ ID NO: 490, SEQ ID NO: 491, SEQ ID NO: 995, SEQ ID NO: 997, SEQ ID NO: 1005, and SEQ ID NO: 1028.

In another embodiment, the H pylori cytoplasmic polypeptide or a fragment thereof is an H pylori polypeptide involved in energy conversion or a fragment thereof encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 470 and SEQ ID NO: 1033.

In another embodiment, the H pylori cytoplasmic polypeptide or a fragment thereof is an H pylori polypeptide involved in amino acid metabolism and transport or a fragment thereof encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 357 and SEQ ID NO: 457. In another embodiment, the H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide involved in nucleotide metabolism and transport or a fragment thereof encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 461 and SEQ ID NO: 1030. In another embodiment, the H pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide involved in cofactor metabolism or a fragment thereof encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 345, SEQ ID NO: 383, SEQ ID NO: 387, SEQ ID NO: 455, and SEQ ID NO: 1003. In another embodiment, the H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide involved in lipid metabolism or a fragment thereof encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 351 and SEQ ID NO: 416.

In another embodiment, the H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide involved in genome replication, transcription, recombination and repair or a fragment thereof encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 278, SEQ ID NO: 335, SEQ ID NO: 346, SEQ ID NO: 350, SEQ ID NO: 419, SEQ ID NO: 460, SEQ ID NO: 472, SEQ ID NO: 1000, SEQ ID NO: 1004, SEQ ID NO: 1020, and SEQ ID NO: 1293.

Particularly preferred is an isolated nucleic acid comprising a nucleotide sequence encoding an H. pylori secreted polypeptide or a fragment thereof. Such nucleic acid is selected from the group consisting of SEQ ID NO: 355, SEQ ID NO: 1006, SEQ ID NO: 257, SEQ ID NO: 258, SEQ ID NO: 260, SEQ ID NO: 261, SEQ ID NO: 264, SEQ ID NO: 265, SEQ ID NO: 268, SEQ ID NO: 270, SEQ ID NO: 272, SEQ ID NO: 274, SEQ ID NO: 275, SEQ ID NO: 276, SEQ ID NO: 279, SEQ ID NO: 283, SEQ ID NO: 284, SEQ ID NO: 287, SEQ ID NO: 288, SEQ ID NO: 289, SEQ ID NO: 291, SEQ ID NO: 295, SEQ ID NO: 296, SEQ ID NO: 297, SEQ ID NO: 298, SEQ ID NO: 300, SEQ ID NO: 301, SEQ ID NO: 302, SEQ ID NO: 303, SEQ ID NO: 304, SEQ ID NO: 305, SEQ ID NO: 314, SEQ ID NO: 315, SEQ ID NO: 323, SEQ ID NO: 338, SEQ ID NO: 342, SEQ ID NO: 348, SEQ ID NO: 349, SEQ ID NO: 356, SEQ ID NO: 358, SEQ ID NO: 359, SEQ ID NO: 360, SEQ ID NO: 361, SEQ ID NO: 362, SEQ ID NO: 363, SEQ ID NO: 367, SEQ ID NO: 370, SEQ ID NO: 371, SEQ ID NO: 373, SEQ ID NO: 377, SEQ ID NO: 378, SEQ ID NO: 379, SEQ ID NO: 380, SEQ ID NO: 388, SEQ ID NO: 390, SEQ ID NO: 394, SEQ ID NO: 395, SEQ ID NO: 396, SEQ ID NO: 401, SEQ ID NO: 403, SEQ ID NO: 405, SEQ ID NO: 408, SEQ ID NO: 420, SEQ ID NO: 426, SEQ ID NO: 428, SEQ ID NO: 429, SEQ ID NO: 432, SEQ ID NO: 439, SEQ ID NO: 442, SEQ ID NO: 451, SEQ ID NO: 471, SEQ ID NO: 478, SEQ ID NO: 488, SEQ ID NO: 987, SEQ ID NO: 990, SEQ ID NO: 991, SEQ ID NO: 993, SEQ ID NO: 1001, SEQ ID NO: 1002, SEQ ID NO: 1007, SEQ ID NO: 1013, SEQ ID NO: 1016, SEQ ID NO: 1018, SEQ ID NO: 1021, and SEQ ID NO: 1026.

In another embodiment, the H. pylori secreted polypeptide or a fragment thereof is an H. pylori polypeptide involved in secretion and adhesion or a fragment thereof encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 355 and SEQ ID NO: 1006.

Particularly preferred is an isolated nucleic acid comprising a nucleotide sequence encoding an H. pylori cellular polypeptide or a fragment thereof. Such nucleic acid is selected from the group consisting of SEQ ID NO: 256, SEQ ID NO: 267, SEQ ID NO: 282, SEQ ID NO: 306, SEQ ID NO: 307, SEQ ID NO: 308, SEQ ID NO: 309, SEQ ID NO: 310, SEQ ID NO: 316, SEQ ID NO: 317, SEQ ID NO: 332, SEQ ID NO: 333, SEQ ID NO: 336, SEQ ID NO: 337, SEQ ID NO: 339, SEQ ID NO: 340, SEQ ID NO: 341, SEQ ID NO: 344, SEQ ID NO: 369, SEQ ID NO: 376, SEQ ID NO: 382, SEQ ID NO: 386, SEQ ID NO: 423, SEQ ID NO: 431, SEQ ID NO: 435, SEQ ID NO: 436, SEQ ID NO: 458, SEQ ID NO: 462, SEQ ID NO: 475, SEQ ID NO: 476, SEQ ID NO: 479, SEQ ID NO: 480, SEQ ID NO: 481, SEQ ID NO: 482, SEQ ID NO: 483, SEQ ID NO: 484, SEQ ID NO: 485, SEQ ID NO: 486, SEQ ID NO: 487, SEQ ID NO: 489, SEQ ID NO: 984, SEQ ID NO: 994, SEQ ID NO: 1024, and SEQ ID NO: 1036. Particularly preferred is a purified or isolated H. pylori cell envelope polypeptide or a fragment thereof, wherein the polypeptide is selected from the group consisting of SEQ ID NO: 746, SEQ ID NO: 754, SEQ ID NO: 757, SEQ ID NO: 768, SEQ ID NO: 771, SEQ ID NO: 776, SEQ ID NO: 783, SEQ ID NO: 785, SEQ ID NO: 790, SEQ ID NO: 802, SEQ ID NO: 803, SEQ ID NO: 804, SEQ ID NO: 812, SEQ ID NO: 818, SEQ ID NO: 820, SEQ ID NO: 882, SEQ ID NO: 844, SEQ ID NO: 855, SEQ ID NO: 857, SEQ ID NO: 859, SEQ ID NO: 866, SEQ ID NO: 875, SEQ ID NO: 882, SEQ ID NO: 883, SEQ ID NO: 888, SEQ ID NO: 889, SEQ ID NO: 893, SEQ ID NO: 895, SEQ ID NO: 900, SEQ ID NO: 901, SEQ ID NO: 903, SEQ ID NO: 918, SEQ ID NO: 924, SEQ ID NO: 925, SEQ ID NO: 932, SEQ ID NO: 935, SEQ ID NO: 936, SEQ ID NO: 940, SEQ ID NO: 941, SEQ ID NO: 943, SEQ ID NO: 944, SEQ ID NO: 957, SEQ ID NO: 959, SEQ ID NO: 960, SEQ ID NO: 1037, SEQ ID NO: 1043, SEQ ID NO: 1062, SEQ ID NO: 1065, SEQ ID NO: 1068, SEQ ID NO: 1069, SEQ ID NO: 1083, SEQ ID NO: 1086, SEQ ID NO: 750, SEQ ID NO: 777, SEQ ID NO: 817, SEQ ID NO: 865, SEQ ID NO: 890, SEQ ID NO: 913, SEQ ID NO: 945, SEQ ID NO: 956, SEQ ID NO: 1052, SEQ ID NO: 1063, SEQ ID NO: 1077, SEQ ID NO: 1297, SEQ ID NO: 1298, SEQ ID NO: 810, SEQ ID NO: 816, SEQ ID NO: 916, SEQ ID NO: 928, SEQ ID NO: 929, SEQ ID NO: 938, SEQ ID NO: 939, SEQ ID NO: 958, SEQ ID NO: 1050, SEQ ID NO: 1081, SEQ ID NO: 1085, SEQ ID NO: 745, SEQ ID NO: 843, SEQ ID NO: 906, SEQ ID NO: 1073, SEQ ID NO: 872, SEQ ID NO: 880, SEQ ID NO: 1064, SEQ ID NO: 1066, SEQ ID NO: 845, SEQ ID NO: 863, SEQ ID NO: 891, SEQ ID NO: 912, SEQ ID NO: 1076, SEQ ID NO: 954, SEQ ID NO: 772, SEQ ID NO: 1042, SEQ ID NO: 902, SEQ ID NO: 898, SEQ ID NO: 1071, SEQ ID NO: 781, SEQ ID NO: 908, SEQ ID NO: 921, SEQ ID NO: 1046, SEQ ID NO: 1079, SEQ ID NO: 968, SEQ ID NO: 905, SEQ ID NO: 744, SEQ ID NO: 784, SEQ ID NO: 825, SEQ ID NO: 834, SEQ ID NO: 909, SEQ ID NO: 915, and SEQ ID NO: 934. In another embodiment, the H. pylori cell envelope polypeptide or a fragment thereof is an H pylori outer membrane polypeptide or a fragment thereof selected from the group consisting of SEQ ID NO: 746, SEQ ID NO: 754, SEQ ID NO: 757, SEQ ID NO: 768, SEQ ID NO: 771, SEQ ID NO: 776, SEQ ID NO: 783, SEQ ID NO: 785, SEQ ID NO: 790, SEQ ID NO: 802, SEQ ID NO: 803, SEQ ID NO: 804, SEQ ID NO: 812, SEQ ID NO: 818, SEQ ID NO: 820, SEQ ID NO: 882, SEQ ID NO: 844, SEQ ID NO: 855, SEQ ID NO: 857, SEQ ID NO: 859, SEQ ID NO: 866, SEQ ID NO: 875, SEQ ID NO: 882, SEQ ID NO: 883, SEQ ID NO: 888, SEQ ID NO: 889, SEQ ID NO: 893, SEQ ID NO: 895, SEQ ID NO: 900, SEQ ID NO: 901, SEQ ID NO: 903, SEQ ID NO: 918, SEQ ID NO: 924, SEQ ID NO: 925, SEQ ID NO: 932, SEQ ID NO: 935, SEQ ID NO: 936, SEQ ID NO: 940, SEQ ID NO: 941, SEQ ID NO: 943, SEQ ID NO: 944, SEQ ID NO: 957, SEQ ID NO: 959, SEQ ID NO: 960, SEQ ID NO: 1037, SEQ ID NO: 1043, SEQ ID NO: 1062, SEQ ID NO: 1065, SEQ ID NO: 1068, SEQ ID NO: 1069, SEQ ID NO: 1083, SEQ ID NO: 1086, SEQ ID NO: 750, SEQ ID NO: 777, SEQ ID NO: 817, SEQ ID NO: 865, SEQ ID NO: 890, SEQ ID NO: 913, SEQ ID NO: 945, SEQ ID NO: 956, SEQ ID NO: 1052, SEQ ID NO: 1063, SEQ ID NO: 1077, SEQ ID NO: 1297, SEQ ID NO: 1298, SEQ ID NO: 810, SEQ ID NO: 816, SEQ ID NO: 916, SEQ ID NO: 928, SEQ ID NO: 929, SEQ ID NO: 938, SEQ ID NO: 939, SEQ ID NO: 958, SEQ ID NO: 1050, SEQ ID NO: 1081, SEQ ID NO: 1085, SEQ ID NO: 745, SEQ ID NO: 843, SEQ ID NO: 906, SEQ ID NO: 1073, SEQ ID NO: 872, SEQ ID NO: 880, SEQ ID NO: 1064, and SEQ ID NO: 1066.

In another embodiment, the H pylori outer membrane polypeptide or a fragment thereof is an H. pylori polypeptide having a terminal phenylalanine residue or a fragment thereof selected from the group consisting of SEQ ID NO: 746, SEQ ID NO: 754, SEQ ID NO: 757, SEQ ID NO: 768, SEQ ID NO: 771, SEQ ID NO: 776, SEQ ID NO: 783, SEQ ID NO: 785, SEQ ID NO: 790, SEQ ID NO: 802, SEQ ID NO: 803, SEQ ID NO: 804, SEQ ID NO: 812, SEQ ID NO: 818, SEQ ID NO: 820, SEQ ID NO: 882, SEQ ID NO: 844, SEQ ID NO: 855, SEQ ID NO: 857, SEQ ID NO: 859, SEQ ID NO: 866, SEQ ID NO: 875, SEQ ID NO: 882, SEQ ID NO: 883, SEQ ID NO: 888, SEQ ID NO: 889, SEQ ID NO: 893, SEQ ID NO: 895, SEQ ID NO: 900, SEQ ID NO: 901, SEQ ID NO: 903, SEQ ID NO: 918, SEQ ID NO: 924, SEQ ID NO: 925, SEQ ID NO: 932, SEQ ID NO: 935, SEQ ID NO: 936, SEQ ID NO: 940, SEQ ID NO: 941, SEQ ID NO: 943, SEQ ID NO: 944, SEQ ID NO: 957, SEQ ID NO: 959, SEQ ID NO: 960, SEQ ID NO: 1037, SEQ ID NO: 1043, SEQ ID NO: 1062, SEQ ID NO: 1065, SEQ ID NO: 1068, SEQ ID NO: 1069, SEQ ID NO: 1083, and SEQ ID NO: 1086.

In another embodiment, the H. pylori outer membrane polypeptide or a fragment thereof is an H. pylori polypeptide having a C-terminal tyrosine cluster or a fragment thereof selected from the group consisting of SEQ ID NO: 777, SEQ ID NO: 817, SEQ ID NO: 865, SEQ ID NO: 890, SEQ ID NO: 913, SEQ ID NO: 945, SEQ ID NO: 956, SEQ ID NO: 1052, SEQ ID NO: 1063, SEQ ID NO: 1077, SEQ ID NO: 1297, and SEQ ID NO: 1298. In another embodiment, the H. pylori outer membrane polypeptide or a fragment thereof is an H. pylori polypeptide having a terminal phenylalanine residue and a C- terminal tyrosine cluster or a fragment thereof selected from the group consisting of SEQ ID NO: 810, SEQ ID NO: 816, SEQ ID NO: 916, SEQ ID NO: 928, SEQ ID NO: 929, SEQ ID NO: 938, SEQ ID NO: 939, SEQ ID NO: 958, SEQ ID NO: 1050, SEQ ID NO: 1081, and SEQ ID NO: 1085.

In another embodiment, the H. pylori cell envelope polypeptide or a fragment thereof is an H pylori inner membrane polypeptide or a fragment thereof selected from the group consisting of SEQ ID NO: 845, SEQ ID NO: 863, SEQ ID NO: 891, SEQ ID NO: 912, SEQ ID NO: 1076, SEQ ID NO: 954, SEQ ID NO: 772, SEQ ID NO: 1042, SEQ ID NO: 902, SEQ ID NO: 898, SEQ ID NO: 1071, SEQ ID NO: 781, SEQ ID NO: 908, SEQ ID NO: 921, SEQ ID NO: 1046, and SEQ ID NO: 1079.

In another embodiment, the H pylori inner membrane polypeptide or a fragment thereof is an H. pylori polypeptide involved in outer membrane and cell wall synthesis or a fragment thereof comprising an amino acid sequence of SEQ ID NO: 845. In another embodiment, the H. pylori inner membrane polypeptide or a fragment thereof is an H. pylori polypeptide involved in energy conversion or a fragment thereof selected from the group consisting of SEQ ID NO: 863, SEQ ID NO: 891, SEQ ID NO: 912, and SEQ ID NO: 1076.

In another embodiment, the H pylori inner membrane polypeptide or a fragment thereof is an H pylori polypeptide involved in cofactor metabolism or a fragment thereof comprising an amino acid sequence of SEQ ID NO: 954. In another embodiment, the H. pylori inner membrane polypeptide or a fragment thereof is an H. pylori polypeptide involved in secretion or adhesion or a fragment thereof selected from the group consisting of SEQ ID NO: 772 and SEQ ID NO: 1042. In another embodiment, the H pylori inner membrane polypeptide or a fragment thereof is an H. pylori polypeptide involved in transport or a fragment thereof selected from the group consisting of SEQ ID NO: 898 and SEQ ID NO: 1071.

In another embodiment, the H. pylori cell envelope polypeptide or a fragment thereof is an H. pylori flagellar polypeptide or a fragment thereof comprising an amino acid sequence of SEQ ID NO: 968. In another embodiment, the H. pylori cell envelope polypeptide or a fragment thereof is an H. pylori transport polypeptide or a fragment thereof comprising an amino acid sequence of SEQ ID NO: 905.

Particularly preferred is a purified or isolated H. pylori cytoplasmic polypeptide or a fragment thereof, wherein the polypeptide is selected from the group consisting of SEQ ID NO: 961, SEQ ID NO: 1087, SEQ ID NO: 848, SEQ ID NO: 948, SEQ ID NO: 952, SEQ ID NO: 1084, SEQ ID NO: 836, SEQ ID NO: 874, SEQ ID NO: 878, SEQ ID NO: 946, SEQ ID NO: 1057, SEQ ID NO: 842, SEQ ID NO: 907, SEQ ID NO: 769, SEQ ID NO: 826, SEQ ID NO: 837, SEQ ID NO: 841, SEQ ID NO: 910, SEQ ID NO: 951, SEQ ID NO: 963, SEQ ID NO: 1054, SEQ ID NO: 1058, SEQ ID NO: 1074, SEQ ID NO: 1296, SEQ ID NO: 809, SEQ ID NO: 813, SEQ ID NO: 815, SEQ ID NO: 821, SEQ ID NO: 838, SEQ ID NO: 931, SEQ ID NO: 937, SEQ ID NO: 955, SEQ ID NO: 981, SEQ ID NO: 982, SEQ ID NO: 1049, SEQ ID NO: 1051, SEQ ID NO: 1059, and SEQ ID NO: 1082.

In another embodiment, the H pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide involved in energy conversion or a fragment thereof selected from the group consisting of SEQ ID NO: 961 and SEQ ID NO: 1087.

In another embodiment, the H. pylori cytoplasmic polypeptide or a fragment thereof is an H pylori polypeptide involved in amino acid metabolism and transport or a fragment thereof selected from the group consisting of SEQ ID NO: 848 and SEQ ID NO: 948.

In another embodiment, the H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide involved in nucleotide metabolism and transport or a fragment thereof selected from the group consisting of SEQ ID NO: 952 and SEQ ID NO: 1084. In another embodiment, the H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide involved in cofactor metabolism or a fragment thereof selected from the group consisting of SEQ ID NO: 836, SEQ ID NO: 874, SEQ ID NO: 878, SEQ ID NO: 946, and SEQ ID NO: 1057.

In another embodiment, the H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide involved in lipid metabolism or a fragment thereof selected from the group consisting of SEQ ID NO: 842, SEQ ID NO: 907.

In another embodiment, the H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide involved in genome replication, transcription, recombination and repair or a fragment thereof selected from the group consisting of SEQ ID NO: 769, SEQ ID NO: 826, SEQ ID NO: 837, SEQ ID NO: 841, SEQ ID NO: 910, SEQ ID NO: 951, SEQ ID NO: 963, SEQ ID NO: 1054, SEQ ID NO: 1058, SEQ ID NO: 1074, and SEQ ID NO: 1296.

Particularly preferred is a purified or isolated H. pylori secreted polypeptide or a fragment thereof, wherein the polypeptide is selected from the group consisting of SEQ ID NO: 846, SEQ ID NO: 1060, SEQ ID NO: 748, SEQ ID NO: 749, SEQ ID NO: 751, SEQ ID NO: 752, SEQ ID NO: 755, SEQ ID NO: 756, SEQ ID NO: 759, SEQ ID NO: 761, SEQ ID NO: 763, SEQ ID NO: 765, SEQ ID NO: 766, SEQ ID NO: 767, SEQ ID NO: 770, SEQ ID NO: 774, SEQ ID NO: 775, SEQ ID NO: 778, SEQ ID NO: 779, SEQ ID NO: 780, SEQ ID NO: 782, SEQ ID NO: 786, SEQ ID NO: 787, SEQ ID NO: 788, SEQ ID NO: 789, SEQ ID NO: 791, SEQ ID NO: 792, SEQ ID NO: 793, SEQ ID NO: 794, SEQ ID NO: 795, SEQ ID NO: 796, SEQ ID NO: 805, SEQ ID NO: 806, SEQ ID NO: 814, SEQ ID NO: 829, SEQ ID NO: 833, SEQ ID NO: 839, SEQ ID NO: 840, SEQ ID NO: 847, SEQ ID NO: 849, SEQ ID NO: 850, SEQ ID NO: 851, SEQ ID NO: 852, SEQ ID NO: 853, SEQ ID NO: 854, SEQ ID NO: 858, SEQ ID NO: 861, SEQ ID NO: 862, SEQ ID NO: 864, SEQ ID NO: 868, SEQ ID NO: 869, SEQ ID NO: 870, SEQ ID NO: 871, SEQ ID NO: 879, SEQ ID NO: 881, SEQ ID NO: 885, SEQ ID NO: 886, SEQ ID NO: 887, SEQ ID NO: 892, SEQ ID NO: 894, SEQ ID NO: 896, SEQ ID NO: 899, SEQ ID NO: 911, SEQ ID NO: 917, SEQ ID NO: 919, SEQ ID NO: 920, SEQ ID NO: 923, SEQ ID NO: 930, SEQ ID NO: 933, SEQ ID NO: 942, SEQ ID NO: 962, SEQ ID NO: 969, SEQ ID NO: 979, SEQ ID NO: 1041, SEQ ID NO: 1044, SEQ ID NO: 1045, SEQ ID NO: 1047, SEQ ID NO: 1055, SEQ ID NO: 1056, SEQ ID NO: 1061, SEQ ID NO: 1067, SEQ ID NO: 1070, SEQ ID NO: 1072, SEQ ID NO: 1075, and SEQ ID NO: 1080.

In another embodiment, the H. pylori secreted polypeptide or a fragment thereof is an H. pylori polypeptide involved in secretion and adhesion or a fragment thereof selected from the group consisting of SEQ ID NO: 846 and SEQ ID NO: 1060. Particularly preferred is a purified or isolated H. pylori cellular polypeptide or a fragment thereof, wherein the polypeptide is selected from the group consisting of SEQ ID NO: 747, SEQ ID NO: 758, SEQ ID NO: 773, SEQ ID NO: 797, SEQ ID NO: 798, SEQ ID NO: 799, SEQ ID NO: 800, SEQ ID NO: 801, SEQ ID NO: 807, SEQ ID NO: 808, SEQ ID NO: 823, SEQ ID NO: 824, SEQ ID NO: 827, SEQ ID NO: 828, SEQ ID NO: 830, SEQ ID NO: 831, SEQ ID NO: 832, SEQ ID NO: 835, SEQ ID NO: 860, SEQ ID NO: 867, SEQ ID NO: 873, SEQ ID NO: 877, SEQ ID NO: 914, SEQ ID NO: 922, SEQ ID NO: 926, SEQ ID NO: 927, SEQ ID NO: 949, SEQ ID NO: 953, SEQ ID NO: 966, SEQ ID NO: 967, SEQ ID NO: 970, SEQ ID NO: 971, SEQ ID NO: 972, SEQ ID NO: 973, SEQ ID NO: 974, SEQ ID NO: 975, SEQ ID NO: 976, SEQ ID NO: 977, SEQ ID NO: 978, SEQ ID NO: 980, SEQ ID NO: 1038, SEQ ID NO: 1048, SEQ ID NO: 1078, and SEQ ID NO: 1090.

In another aspect, the invention pertains to any individual H. pylori polypeptide member or nucleic acid encoding such a member from the above-identified groups of H. pylori polypeptides.

In another aspect, the invention features nucleic acids capable of binding mRNA of H. pylori. Such nucleic acid is capable of acting as antisense nucleic acid to control the translation of mRNA of H. pylori. A further aspect features a nucleic acid which is capable of binding specifically to an H. pylori nucleic acid. These nucleic acids are also referred to herein as complements and have utility as probes and as capture reagents. In another aspect, the invention features an expression system comprising an open reading frame corresponding to H. pylori nucleic acid. The nucleic acid further comprises a control sequence compatible with an intended host. The expression system is useful for making polypeptides corresponding to H. pylori nucleic acid. In another aspect, the invention features a cell transformed with the expression system to produce H. pylori polypeptides.

In another aspect, the invention features a method of generating antibodies against H. pylori polypeptides which are capable of binding specifically to H. pylori polypeptides. Such antibody has utility as reagents for immunoassays to evaluate the abundance and distribution of H. /? /or -specific antigens.

In another aspect, the invention features a method of generating vaccines for immunizing an individual against H. pylori. The method includes: immunizing a subject with an H pylori polypeptide, e.g., a surface or secreted polypeptide, or active portion thereof, and a pharmaceutically acceptable carrier. Such vaccines have therapeutic and prophylactic utilities. In another aspect, the invention provides a method for generating a vaccine comprising a modified immunogenic H. pylori polypeptide, e.g., a surface or secreted polypeptide, or active portion thereof, and a pharmacologically acceptable carrier.

In another aspect, the invention features a method of evaluating a compound, e.g. a polypeptide, e.g., a fragment of a host cell polypeptide, for the ability to bind an H. pylori polypeptide. The method includes: contacting the candidate compound with an H pylori polypeptides and determining if the compound binds or otherwise interacts with an H. pylori polypeptide. Compounds which bind H. pylori are candidates as activators or inhibitors of the bacterial life cycle. These assays can be performed in vitro or in vivo.

In another aspect, the invention features a method of evaluating a compound, e.g. a polypeptide, e.g., a fragment of a host cell polypeptide, for the ability to bind an H. pylori nucleic acid, e.g., DNA or RNA. The method includes: contacting the candidate compound with an H. pylori nucleic acid and determining if the compound binds or otherwise interacts with an H. pylori polypeptide. Compounds which bind H. pylori are candidates as activators or inhibitors of the bacterial life cycle. These assays can be performed in vitro or in vivo.

The invention features H. pylori polypeptides, preferably a substantially pure preparation of an H. pylori polypeptide, or a recombinant H. pylori polypeptide. In preferred embodiments: the polypeptide has biological activity; the polypeptide has an amino acid sequence at least 60%, 70%, 80%, 90%, 95%, 98%, or 99% homologous to an amino acid sequence contained in the Sequence Listing; the polypeptide has an amino acid sequence essentially the same as an amino acid sequence in the Sequence Listing; the polypeptide is at least 5, 10, 20, 50, 100, or 150 amino acid residues in length; the polypeptide includes at least 5, preferably at least 10, more preferably at least 20, more preferably at least 50, 100, or 150 contiguous amino acid residues of a polypeptide contained in the Sequence Listing.

In preferred embodiments: the H. pylori polypeptide is encoded by a nucleic acid contained in the Sequence Listing, or by a nucleic acid having at least 60%, 70%, 80%, 90%, 95%, 98%, or 99% homology with a nucleic acid shown in the Sequence Listing.

In a preferred embodiment, the subject H pylori polypeptide differs in amino acid sequence at 1, 2, 3, 5, 10 or more residues from a sequence in the Sequence Listing. The differences, however, are such that the H. pylori polypeptide exhibits an H. pylori biological activity, e.g., the H. pylori polypeptide retains a biological activity of a naturally occurring H. pylori enzyme. In preferred embodiments, the polypeptide includes all or a fragment of an amino acid sequence contained in the Sequence Listing; fused, in reading frame, to additional amino acid residues, preferably to residues encoded by genomic DNA 5' to the genomic DNA which encodes a sequence contained in the Sequence Listing. In yet other preferred embodiments, the H. pylori polypeptide is a recombinant fusion protein having a first H. pylori polypeptide portion and a second polypeptide portion, e.g., a second polypeptide portion having an amino acid sequence unrelated to H. pylori. The second polypeptide portion can be, e.g., any of glutathione-S-transferase, a DNA binding domain, or a polymerase activating domain. In preferred embodiment the fusion protein can be used in a two-hybrid assay.

Polypeptides of the invention include those which arise as a result of alternative transcription events, alternative RNA splicing events, and alternative translational and postranslational events.

The invention also encompasses an immunogenic component which includes an H. pylori polypeptide in an immunogenic preparation; the immunogenic component being capable of eliciting an immune response specific for the H. pylori polypeptide, e.g., a humoral response, an antibody response, or a cellular response. In preferred embodiments, the immunogenic component comprises at least one antigenic determinant from a polypeptide contained in the Sequence Listing. In another aspect, the invention provides a substantially pure nucleic acid having a nucleotide sequence which encodes an H. pylori polypeptide. In preferred embodiments: the encoded polypeptide has biological activity; the encoded polypeptide has an amino acid sequence at least 60%, 70%, 80%, 90%, 95%, 98%, or 99% homologous to an amino acid sequence contained in the Sequence Listing; the encoded polypeptide has an amino acid sequence essentially the same as an amino acid sequence in the Sequence Listing; the encoded polypeptide is at least 5, 10, 20, 50, 100, or 150 amino acids in length; the encoded polypeptide comprises at least 5, preferably at least 10, more preferably at least 20, more preferably at least 50, 100, or 150 contiguous amino acids contained in the Sequence Listing. In preferred embodiments: the nucleic acid is that as shown in the Sequence

Listing; the nucleic acid is at least 60%, 70%, 80%, 90%, 95%, 98%, or 99% homologous with a nucleic acid sequence contained in the Sequence Listing.

In a preferred embodiment, the encoded H. pylori polypeptide differs (e.g., by amino acid substitution, addition or deletion of at least one amino acid residue) in amino acid sequence at 1, 2, 3, 5, 10 or more residues, from a sequence in the Sequence

Listing. The differences, however, are such that: the H. pylori encoded polypeptide exhibits a H. pylori biological activity, e.g., the encoded H. pylori enzyme retains a biological activity of a naturally occurring H. pylori.

In preferred embodiments, the encoded polypeptide includes all or a fragment of an amino acid sequence contained in the Sequence Listing; fused, in reading frame, to additional amino acid residues, preferably to residues encoded by genomic DNA 5' to the genomic DNA which encodes a sequence contained in the Sequence Listing.

In preferred embodiments, the subject H. pylori nucleic acid will include a transcriptional regulatory sequence, e.g. at least one of a transcriptional promoter or transcriptional enhancer sequence, operably linked to the H. pylori gene sequence, e.g., to render the H. pylori gene sequence suitable for expression in a recombinant host cell. In yet a further preferred embodiment, the nucleic acid which encodes an H. pylori polypeptide of the invention, hybridizes under stringent conditions to a nucleic acid probe corresponding to at least 8 consecutive nucleotides of a nucleic acid contained in the Sequence Listing; more preferably to at least 12 consecutive nucleotides of a nucleic acid contained in the Sequence Listing; more preferably to at least 20 consecutive nucleotides of a nucleic acid contained in the Sequence Listing; more preferably to at least 40 consecutive nucleotides of a nucleic acid contained in the Sequence Listing.

In a preferred embodiment, the nucleic acid encodes a peptide which differs by at least one amino acid residue from the sequences shown in the Sequence Listing.

In a preferred embodiment, the nucleic acid differs by at least one nucleotide from a nucleotide sequence shown in the Sequence Listing which encodes amino acids shown in the Sequence Listing.

In another aspect, the invention encompasses: a vector including a nucleic acid which encodes an H. pylori polypeptide or an H pylori polypeptide variant as described herein; a host cell transfected with the vector; and a method of producing a recombinant H. pylori polypeptide or H. pylori polypeptide variant; including culturing the cell, e.g., in a cell culture medium, and isolating the H. pylori or H. pylori polypeptide variant e.g., from the cell or from the cell culture medium. In another aspect, the invention features, a purified recombinant nucleic acid having at least 50%, 60%, 70%, 80%, 90%, 95%, 98%, or 99% homology with a sequence contained in the Sequence Listing.

The invention also provides a probe or primer which includes a substantially purified oligonucleotide. The oligonucleotide includes a region of nucleotide sequence which hybridizes under stringent conditions to at least 10 consecutive nucleotides of sense or antisense sequence contained in the Sequence Listing, or naturally occurring mutants thereof. In preferred embodiments, the probe or primer further includes a label group attached thereto. The label group can be, e.g., a radioisotope, a fluorescent compound, an enzyme, and/or an enzyme co-factor. Preferably, the oligonucleotide is at least 10 and less than 20, 30, 50, 100, or 150 nucleotides in length. The invention further provides nucleic acids, e.g., RNA or DNA, encoding a polypeptide of the invention. This includes double stranded nucleic acids as well as coding and antisense single strands.

The H. pylori strain, from which genomic sequences have been sequenced, has been deposited in the American Type Culture Collection(ATCC) as strain HP-J99. Included in the invention are: allelic variations; natural mutants; induced mutants; proteins encoded by DNA that hybridizes under high or low stringency conditions to a nucleic acid which encodes a polypeptide as shown in the Sequence Listing (for definitions of high and low stringency see Current Protocols in Molecular Biology, John Wiley & Sons, New York, 1989, 6.3.1 - 6.3.6, hereby incorporated by reference); and, polypeptides specifically bound by antisera to H. pylori polypeptides, especially by antisera to an active site or binding domain of H. pylori polypeptide. The invention also includes fragments, preferably biologically active fragments. These and other polypeptides are also referred to herein as H. pylori polypeptide analogs or variants. Putative functions have been determined for several of the H. pylori polypeptides of the invention, as shown in Table 1.

Accordingly, uses of the claimed H pylori polypeptides in these identified functions are also within the scope of the invention.

In addition, the present invention encompasses H. pylori polypeptides characterized as shown in Table 1 below, including: H. pylori cell envelope proteins, H. pylori secreted proteins, H. pylori cytoplasmic proteins and H. pylori cellular proteins. Members of these groups were identified by BLAST homology searches and by searches for secretion signal or transmembrane protein motifs. Polypeptides related by significant homology to the polypeptides of Table 1 (as reflected by F ASTA compar- isons of the amino acid sequences and indicated in many cases in Tables 3-6 below) are also considered to be classified in the manner of the homolog shown in Table 1.

TABLE 1

[In Table 1, "nt" represents nucleotide Seq. ID number and "aa" represents amino acid Seq. ID number]

Definitions

A purified preparation or a substantially pure preparation of a polypeptide, as used herein, means a polypeptide that has been separated from other proteins, lipids, and nucleic acids with which it naturally occurs. Preferably, the polypeptide is also separated from substances, e.g., antibodies or gel matrix, e.g., polyacrylamide, which are used to purify it. Preferably, the polypeptide constitutes at least 10, 20, 50 70, 80 or 95% dry weight of the purified preparation. Preferably, the preparation contains: sufficient polypeptide to allow protein sequencing; at least 1, 10, or 100 μg of the polypeptide; at least 1, 10, or 100 mg of the polypeptide.

A purified preparation of cells refers to, in the case of plant or animal cells, an in vitro preparation of cells and not an entire intact plant or animal. In the case of cultured cells or microbial cells, it consists of a preparation of at least 10% and more preferably 50% of the subject cells.

A substantially pure nucleic acid, e.g., a substantially pure DNA, is a nucleic acid which is one or both of the following: not immediately contiguous with both of the coding sequences with which it is immediately contiguous (i.e., one at the 5' end and one at the 3' end) in the naturally-occurring genome of the organism from which the nucleic acid is derived; or which is substantially free of a nucleic acid with which it occurs in the organism from which the nucleic acid is derived. The term includes, for example, a recombinant DNA which is incorporated into a vector, e.g., into an autonomously replicating plasmid or virus, or into the genomic DNA of a prokaryote or eukaryote, or which exists as a separate molecule (e.g., a cDNA or a genomic DNA fragment produced by PCR or restriction endonuclease treatment) independent of other DNA sequences. Substantially pure DNA also includes a recombinant DNA which is part of a hybrid gene encoding additional H. pylori DNA sequence. A "contig" as used herein is a nucleic acid representing a continuous stretch of genomic sequence of an organism. An "open reading frame", also referred to herein as ORF, is a region of nucleic acid which encodes a polypeptide. This region may represent a portion of a coding sequence or a total sequence.

As used herein, a "coding sequence" is a nucleic acid which is transcribed into messenger RNA and/or translated into a polypeptide when placed under the control of appropriate regulatory sequences. The boundaries of the coding sequence are determined by a translation start codon at the five prime terminus and a translation stop code at the three prime terminus. A coding sequence can include but is not limited to messenger RNA, synthetic DNA, and recombinant nucleic acid sequences. A "complement" of a nucleic acid as used herein referes to an anti-parallel or antisense sequence that participates in Watson-Crick base-pairing with the original sequence.

A "gene product" is a protein or structural RNA which is specifically encoded for by a gene. As used herein, the term "probe" refers to a nucleic acid, peptide or other chemical entity which specifically binds to a molecule of interest. Probes are often associated with or capable of associating with a label. A label is a chemical moiety capable of detection. Typical labels comprise dyes, radioisotopes, luminescent and chemiluminescent moieties, fluorophores, enzymes, precipitating agents, amplification sequences, and the like. Similarly, a nucleic acid, peptide or other chemical entity which specifically binds to a molecule of interest and immobilizes such molecule is referred herein as a "capture ligand". Capture ligands are typically associated with or capable of associating with a support such as nitro-cellulose, glass, nylon membranes, beads, particles and the like. The specificity of hybridization is dependent on conditions such as the base pair composition of the nucleotides, and the temperature and salt concentration of the reaction. These conditions are readily discernable to one of ordinary skill in the art using routine experimentation.

Homologous refers to the sequence similarity or sequence identity between two polypeptides or between two nucleic acid molecules. When a position in both of the two compared sequences is occupied by the same base or amino acid monomer subunit, e.g., if a position in each of two DNA molecules is occupied by adenine, then the molecules are homologous at that position. The percent of homology between two sequences is a function of the number of matching or homologous positions shared by the two sequences divided by the number of positions compared x 100. For example, if 6 of 10 of the positions in two sequences are matched or homologous then the two sequences are 60% homologous. By way of example, the DNA sequences ATTGCC and TATGGC share 50% homology. Generally, a comparison is made when two sequences are aligned to give maximum homology.

Nucleic acids are hybridizable to each other when at least one strand of a nucleic acid can anneal to the other nucleic acid under defined stringency conditions. Stringency of hybridization is determined by: (a) the temperature at which hybridization and/or washing is performed; and (b) the ionic strength and polarity of the hybridization and washing solutions. Hybridization requires that the two nucleic acids contain complementary sequences; depending on the stringency of hybridization, however, mismatches may be tolerated. Typically, hybridization of two sequences at high stingency (such as, for example, in a solution of 0.5X SSC, at 65° C) requires that the sequences be essentially completely homologous. Conditions of intermediate stringency (such as, for example, 2X SSC at 65 ° C) and low stringency (such as, for example 2X SSC at 55° C), require correspondingly less overall complementarity between the hybridizing sequences. (IX SSC is 0.15 M NaCl, 0.015 M Na citrate). The terms peptides, proteins, and polypeptides are used interchangeably herein.

As used herein, the term "surface protein" refers to all surface accessible proteins, e.g. inner and outer membrane proteins, proteins adhering to the cell wall, and secreted proteins.

A polypeptide has H. pylori biological activity if it has one, two and preferably more of the following properties: (1) if when expressed in the course of an H. pylori infection, it can promote, or mediate the attachment of H. pylori to a cell; (2) it has an enzymatic activity characteristic of an H. pylori protein; (3) or the gene which encodes it can rescue a lethal mutation in an H. pylori gene. A polypeptide has biological activity if it is an antagonist, agonist, or super-agonist of a polypeptide having one of the above- listed properties.

A biologically active fragment or analog is one having an in vivo or in vitro activity which is characteristic of the H. pylori polypeptides shown in the Sequence Listing, or of other naturally occurring H. pylori polypeptides, e.g., one or more of the biological activities described herein. Especially preferred are fragments which exist in vivo, e.g., fragments which arise from post transcriptional processing or which arise from translation of alternatively spliced RNA's. Fragments include those expressed in native or endogenous cells as well as those made in expression systems, e.g., in CHO cells. Because peptides such as H. pylori polypeptides often exhibit a range of physiological properties and because such properties may be attributable to different portions of the molecule, a useful H. pylori fragment or //. pylori analog is one which exhibits a biological activity in any biological assay for H. pylori activity. Most preferably the fragment or analog possesses 10%, preferably 40%, more preferably 90% or greater of the activity of H. pylori, in any in vivo or in vitro assay.

Analogs can differ from naturally occurring H. pylori polypeptides in amino acid sequence or in ways that do not involve sequence, or both. Non-sequence modifications include changes in acetylation, methylation, phosphorylation, carboxylation, or glycosylation. Preferred analogs include H. pylori polypeptides (or biologically active fragments thereof) whose sequences differ from the wild-type sequence by one or more conservative amino acid substitutions or by one or more non-conservative amino acid substitutions, deletions, or insertions which do not substantially diminish the biological activity of the H. pylori polypeptide. Conservative substitutions typically include the substitution of one amino acid for another with similar characteristics, e.g., substitutions within the following groups: valine, glycine; glycine, alanine; valine, isoleucine, leucine; aspartic acid, glutamic acid; asparagine, glutamine; serine, threonine; lysine, arginine; and phenylalanine, tyrosine. Other conservative substitutions are outlined in Table 2 below.

TABLE 2

CONSERVATIVE AMINO ACID REPLACEMENTS

Other analogs within the invention are those with modifications which increase peptide stability; such analogs may contain, for example, one or more non-peptide bonds (which replace the peptide bonds) in the peptide sequence. Also included are: analogs that include residues other than naturally occurring L-amino acids, e.g., D-amino acids or non-naturally occurring or synthetic amino acids, e.g., β or γ amino acids; and cyclic analogs.

As used herein, the term "fragment", as applied to an H. pylori analog, will ordinarily be at least about 20 residues, more typically at least about 40 residues, preferably at least about 60 residues in length. Fragments of H. pylori polypeptides can be generated by methods known to those skilled in the art. The ability of a candidate fragment to exhibit a biological activity of H. pylori polypeptide can be assessed by methods known to those skilled in the art as described herein. Also included are H. pylori polypeptides containing residues that are not required for biological activity of the peptide or that result from alternative mRNA splicing or alternative protein processing events.

An "immunogenic component" as used herein is a moiety, such as an H. pylori polypeptide, analog or fragment thereof, that is capable of eliciting a humoral and/or cellular immune response in a host animal.

An "antigenic component" as used herein is a moiety, such as an H. pylori polypeptide, analog or fragment thereof, that is capable of binding to a specific antibody with sufficiently high affinity to form a detectable antigen-antibody complex.

As used herein, the term "transgene" means a nucleic acid (encoding, e.g., one or more polypeptides), which is partly or entirely heterologous, i.e., foreign, to the transgenic animal or cell into which it is introduced, or, is homologous to an endogenous gene of the transgenic animal or cell into which it is introduced, but which is designed to be inserted, or is inserted, into the cell's genome in such a way as to alter the genome of the cell into which it is inserted (e.g., it is inserted at a location which differs from that of the natural gene or its insertion results in a knockout). A transgene can include one or more transcriptional regulatory sequences and any other nucleic acid, such as introns, that may be necessary for optimal expression of the selected nucleic acid, all operably linked to the selected nucleic acid, and may include an enhancer sequence.

As used herein, the term "transgenic cell" refers to a cell containing a transgene. As used herein, a "transgenic animal" is any animal in which one or more, and preferably essentially all, of the cells of the animal includes a transgene. The transgene can be introduced into the cell, directly or indirectly by introduction into a precursor of the cell, by way of deliberate genetic manipulation, such as by micro injection or by infection with a recombinant virus. This molecule may be integrated within a chromosome, or it may be extrachromosomally replicating DNA.

The term "antibody" as used herein is intended to include fragments thereof which are specifically reactive with H. pylori polypeptides. As used herein, the term "cell-specific promoter" means a DNA sequence that serves as a promoter, i.e., regulates expression of a selected DNA sequence operably linked to the promoter, and which effects expression of the selected DNA sequence in specific cells of a tissue. The term also covers so-called "leaky" promoters, which regulate expression of a selected DNA primarily in one tissue, but cause expression in other tissues as well.

Misexpression, as used herein, refers to a non-wild type pattern of gene expression. It includes: expression at non-wild type levels, i.e., over or under expression; a pattern of expression that differs from wild type in terms of the time or stage at which the gene is expressed, e.g., increased or decreased expression (as compared with wild type) at a predetermined developmental period or stage; a pattern of expression that differs from wild type in terms of decreased expression (as compared with wild type) in a predetermined cell type or tissue type; a pattern of expression that differs from wild type in terms of the splicing size, amino acid sequence, post- transitional modification, or biological activity of the expressed polypeptide; a pattern of expression that differs from wild type in terms of the effect of an environmental stimulus or extracellular stimulus on expression of the gene, e.g., a pattern of increased or decreased expression (as compared with wild type) in the presence of an increase or decrease in the strength of the stimulus.

As used herein, "host cells" and other such terms denoting microorganisms or higher eukaryotic cell lines cultured as unicellular entities refers to cells which can become or have been used as recipients for a recombinant vector or other transfer DNA, and include the progeny of the original cell which has been transfected. It is understood by individuals skilled in the art that the progeny of a single parental cell may not necessarily be completely identical in genomic or total DNA compliment to the original parent, due to accident or deliberate mutation.

As used herein, the term "control sequence" refers to a nucleic acid having a base sequence which is recognized by the host organism to effect the expression of encoded sequences to which they are ligated. The nature of such control sequences differs depending upon the host organism; in prokaryotes, such control sequences generally include a promoter, ribosomal binding site and terminators; in eukaryotes, generally such control sequences include promoters, terminators and in some instances, enhancers. The term control sequence is intended to include at a minimum, all components whose presence is necessary for expression, and may also include additional components whose presence is advantageous, for example, leader sequences.

As used herein, the term "operably linked" refers to sequences joined or ligated to function in their intended manner. For example, a control sequence is operably linked to coding sequence by ligation in such a way that expression of the coding sequence is achieved under conditions compatible with the control sequence and host cell.

The metabolism of a substance, as used herein, means any aspect of the, expression, function, action, or regulation of the substance. The metabolism of a substance includes modifications, e.g., covalent or non-covalent modifications of the substance. The metabolism of a substance includes modifications, e.g., covalent or non- covalent modification, the substance induces in other substances. The metabolism of a substance also includes changes in the distribution of the substance. The metabolism of a substance includes changes the substance induces in the distribution of other substances.

A "sample" as used herein refers to a biological sample, such as, for example, tissue or fluid isloated from an individual (including without limitation plasma, serum, cerebrospinal fluid, lymph, tears, saliva and tissue sections) or from in vitro cell culture constituents, as well as samples from the environment. The practice of the invention will employ, unless otherwise indicated, conventional techniques of chemistry, molecular biology, microbiology, recombinant DNA, and immunology, which are within the skill of the art. Such techniques are explained fully in the literature. See e.g., Sambrook, Fritsch, and Maniatis, Molecular Cloning; Laboratory Manual 2nd ed. (1989); DNA Cloning, Volumes I and II (D.N Glover ed. 1985); Oligonucleotide Synthesis (M.J. Gait ed, 1984); Nucleic Acid Hybridization (B.D. Hames & S.J. Higgins eds. 1984); the series, Methods in Enzymoloqy (Academic Press, Inc.), particularly Vol. 154 and Vol. 155 (Wu and Grossman, eds.) and PCR-A Practical Approach (McPherson, Quirke, and Taylor, eds., 1991).

I. Isolation of Nucleic Acids of H. pylori and Uses Therefor H. pylori Genomic Sequence

This invention provides nucleotide sequences of the genome of H. pylori which thus comprises a DNA sequence library of H. pylori genomic DNA. The detailed description that follows provides nucleotide sequences of H. pylori, and also describes how the sequences were obtained and how ORFs and protein-coding sequences were identified. Also described are methods of using the disclosed H. pylori sequences in methods including diagnostic and therapeutic applications. Furthermore, the library can be used as a database for identification and comparison of medically important sequences in this and other strains of H. pylori. To determine the genomic sequence of H. pylori, DNA was isolated from a strain of H. pylori and mechanically sheared by nebulization to a median size of 2 kb. Following size fractionation by gel electrophoresis, the fragments were blunt-ended, ligated to adapter oligonucleotides, and cloned into each of 20 different pMPX vectors (Rice et al., abstracts of Meeting of Genome Mapping and Sequencing, Cold Spring Harbor, NY, 5/11-5/15, 1994, p. 225) to construct a series of "shotgun" subclone libraries.

DNA sequencing was achieved using multiplex sequencing procedures essentially as disclosed in Church et al., 1988, Science 240:185; U.S. Patents No. 4,942,124 and 5,149,625). DNA was extracted from pooled cultures and subjected to chemical or enzymatic sequencing. Sequencing reactions were resolved by electrophoresis, and the products were transferred and covalently bound to nylon membranes. Finally, the membranes were sequentially hybridized with a series of labelled oligonucleotides complimentary to "tag" sequences present in the different shotgun cloning vectors. In this manner, a large number of sequences could be obtained from a single set of sequencing reactions. The cloning and sequencing procedures are described in more detail in the Exemplification.

Individual sequence reads obtained in this manner were assembled using the FALCON™ program (Church et al, 1994, Automated DNA Sequencing and Analysis, J.C. Venter, ed., Academic Press) and PHRAP (P. Green, Abstracts of DOE Human Genome Program Contractor-Grantee Workshop V, Jan. 1996, p.157). A resulting assembly of contigs, each representing a continuous stretch of DNA or DNA sequence was obtained. The average contig length was about 3 kb.

A variety of approaches are used to order the contigs so as to obtain a continuous sequence representing the entire H. pylori genome. Synthetic oligonucleotides are designed that are complementary to sequences at the end of each contig. These oligonucleotides may be hybridized to libaries of H. pylori genomic DNA in, for example, lambda phage vectors or plasmid vectors to identify clones that contain sequences corresponding to the junctional regions between individual contigs. Such clones are then used to isolate template DNA and the same oligonucleotides are used as primers in polymerase chain reaction (PCR) to amplify junctional fragments, the nucleotide sequence of which was then determined. The H. pylori sequences were analyzed for the presence of open reading frames (ORFs) comprising at least 180 nucleotides. ORFs of at least 180 nucleotides (based on stop-to-stop codon reads) were predicted. As a result of the analysis of ORFs based on stop-to-stop codon reads, it should be understood that these ORFs may not correspond to the ORF of a naturally-occurring H. pylori polypeptide. These ORFs may contain start codons which indicate the initiation of protein synthesis of a naturally-occurring H jpy/orz^'polypeptide. Such start codons within the ORFs provided herein can be identified by those of ordinary skill in the relevant art and the resulting ORF and the encoded H. pylori polypeptide is within the scope of this invention. For example, within the ORFs a codon such as AUG or GUG (encoding methionine or valine) which is part of the initiation signal for protein synthesis can be identified and the ORF modified to correspond to a naturally-occurring H. pylori polypeptide. The predicted coding regions were defined by evaluating the coding potential of such sequences with the program GENEMARK™ (Borodovsky and Mclninch, 1993, Comp. Chem. 17:123). Other H. pylori Nucleic Acids

The nucleic acids of this invention may be obtained directly from the DNA of the above referenced H. pylori strain by using the polymerase chain reaction (PCR). See "PCR, A Practical Approach" (McPherson, Quirke, and Taylor, eds., IRL Press, Oxford, UK, 1991) for details about the PCR. High fidelity PCR can be used to ensure a faithful DNA copy prior to expression. In addition, amplified products can be checked by conventional sequencing methods. Clones carrying the desired sequences described in this invention may be obtained by screening the libraries by means of the PCR or by hybridization of synthetic oligonucleotide probes to filter lifts of the library colonies or plaques as known in the art (see, e.g., Sambrook et al., Molecular Cloning, A Laboratory Manual 2nd edition, 1989, Cold Spring Harbor Press, NY).

It is also be possible to obtain nucleic acids encoding H pylori polypeptides from a cDNA library in accordance with protocols herein described. A cDNA encoding an H. pylori polypeptide can be obtained by isolating total mRNA from an appropriate cell line. Double stranded cDNAs can then be prepared from the total mRNA. Subsequently, the cDNAs can be inserted into a suitable plasmid or viral (e.g., bacteriophage) vector using any one of a number of known techniques. Genes encoding H pylori polypeptides can also be cloned using established polymerase chain reaction techniques in accordance with the nucleotide sequence information provided by the invention. The nucleic acids of the invention can be DNA or RNA. Preferred nucleic acids are shown in the Sequence Listing. The nucleic acids of the invention can also be chemically synthesized using standard techniques. Various methods of chemically synthesizing polydeoxynucleotides are known, including solid-phase synthesis which, like peptide synthesis, has been fully automated in commercially available DNA synthesizers (See e.g., Itakura et al U.S. Patent No. 4,598,049; Caruthers et a U.S. Patent No. 4,458,066; and Itakura U.S. Patent Nos. 4,401,796 and 4,373,071, incorporated by reference herein).

Nucleic acids isolated or synthesized in accordance with features of the present invention are useful, by way of example, without limitation, as probes, primers, capture ligands, antisense genes and for developing expression systems for the synthesis of proteins and peptides corresponding to such sequences. As probes, primers, capture ligands and antisense agents, the nucleic acid normally consists of all or part (approximately twenty or more nucleotides for specificity as well as the ability to form stable hybridization products) of the nucleic acids shown in the Sequence Listing. These uses are described in further detail below. Probes

A nucleic acid isolated or synthesized in accordance with the nucleotide sequences set forth in the Sequence Listing can be used as a probe to specifically detect H. pylori. With the sequence information set forth in the present application, sequences of twenty or more nucleotides are identified which provide the desired inclusivity and exclusivity with respect to H. pylori, and extraneous nucleic acids likely to be encountered during hybridization conditions. More preferably, the sequence will comprise at least twenty to thirty nucleotides to convey stability to the hybridization product formed between the probe and the intended target molecules.

Sequences larger than 1000 nucleotides in length are difficult to synthesize but can be generated by recombinant DNA techniques. Individuals skilled in the art will readily recognize that the nucleic acids, for use as probes, can be provided with a label to facilitate detection of a hybridization product.

Nucleic acid isolated and synthesized in accordance with the Sequence Listing can also be useful as probes to detect homologous regions (especially homologous genes) of other Helicobacter species using appropriate stringency hybridization conditions as described herein. Capture Ligand

For use as a capture ligand, the nucleic acid selected in the manner described above with respect to probes, can be readily associated with a support. The manner in which nucleic acid is associated with supports is well known. Nucleic acid having twenty or more nucleotides in a sequence contained in the Sequence Listing have utility to separate H. pylori nucleic acid from the nucleic acid of each other and other organisms. Nucleic acid having twenty or more nucleotides in a sequence shown in the Sequence Listing can also have utility to separate other Helicobacter species from each other and from other organisms. Preferably, the sequence will comprise at least twenty nucleotides to convey stability to the hybridization product formed between the probe and the intended target molecules. Sequences larger than 1000 nucleotides in length are difficult to synthesize but can be generated by recombinant DNA techniques. Primers Nucleic acid isolated or synthesized in accordance with the sequences described herein have utility as primers for the amplification of H. pylori nucleic acid. These nucleic acids may also have utility as primers for the amplification of nucleic acids in other Helicobacter species. With respect to polymerase chain reaction (PCR) techniques, nucleic acids of > 10-15 nucleotides contained in the Sequence Listing have utility in conjunction with suitable enzymes and reagents to create copies of H pylori nucleic acid. More preferably, the sequence will comprise twenty or more nucleotides to convey stability to the hybridization product formed between the primer and the intended target molecules. Binding conditions of primers greater than 100 nucleotides are more difficult to control to obtain specificity. High fidelity PCR can be used to ensure a faithful DNA copy prior to expression. In addition, amplified products can be checked by conventional sequencing methods.

The copies can be used in diagnostic assays to detect specific sequences, including genes from H. pylori and/or other Helicobacter species. The copies can also be incorporated into cloning and expression vectors to generate polypeptides corresponding to the nucleic acid synthesized by PCR, as is described in greater detail herein.

Antisense

Nucleic acid or nucleic acid-hybridizing derivatives isolated or synthesized in accordance with the sequences described herein have utility as antisense agents to prevent the expression of H. pylori genes. These sequences also have utility as antisense agents to prevent expression of genes of other Helicobacter species.

In one embodiment, nucleic acid or derivatives corresponding to H. pylori nucleic acids is loaded into a suitable carrier such as a liposome or bacteriophage for introduction into bacterial cells. For example, a nucleic acid having twenty or more nucleotides is capable of binding to bacteria nucleic acid or bacteria messenger RNA. Preferably, the antisense nucleic acid is comprised of 20 or more nucleotides to provide necessary stability of a hybridization product of non-naturally occurring nucleic acid and bacterial nucleic acid and/or bacterial messenger RNA. Nucleic acid having a sequence greater than 1000 nucleotides in length is difficult to synthesize but can be generated by recombinant DNA techniques. Methods for loading antisense nucleic acid in liposomes is known in the art as exemplified by U.S. Patent 4,241,046 issued December 23, 1980 to Papahadjopoulos et al.

II. Expression of H. pylori Nucleic Acids

Nucleic acid isolated or synthesized in accordance with the sequences described herein have utility to generate polypeptides. The nucleic acids exemplified in the Sequence Listing or fragments of said nucleic acid encoding active portions of H. pylori polypeptides can be cloned into suitable vectors or used to isolate nucleic acid. The isolated nucleic acid is combined with suitable DNA linkers and cloned into a suitable vector.

The function of a specific gene or operon can be ascertained by expression in a bacterial strain under conditions where the activity of the gene product(s) specified by the gene or operon in question can be specifically measured. Alternatively, a gene product may be produced in large quantities in an expressing strain for use as an antigen, an industrial reagent, for structural studies, etc. This expression can be accomplished in a mutant strain which lacks the activity of the gene to be tested, or in a strain that does not produce the same gene product(s). This includes, but is not limited to other Helicobacter strains, and other bacterial strains such as E. coli, Norcardia, Corynebacterium, and Streptomyces species. In some cases the expression host will utilize the natural Helicobacter promoter whereas in others, it will be necessary to drive the gene with a promoter sequence derived from the expressing organism (e.g., an E. coli beta-galactosidase promoter for expression in E. coli).

To express a gene product using the natural H. pylori promoter, a procedure such as the following can be used. A restriction fragment containing the gene of interest, together with its associated natural promoter element and regulatory sequences (identified using the DNA sequence data) is cloned into an appropriate recombinant plasmid containing an origin of replication that functions in the host organism and an appropriate selectable marker. This can be accomplished by a number of procedures known to those skilled in the art. It is most preferably done by cutting the plasmid and the fragment to be cloned with the same restriction enzyme to produce compatible ends that can be ligated to join the two pieces together. The recombinant plasmid is intro- duced into the host organism by, for example, electroporation and cells containing the recombinant plasmid are identified by selection for the marker on the plasmid. Expression of the desired gene product is detected using an assay specific for that gene product.

In the case of a gene that requires a different promoter, the body of the gene (coding sequence) is specifically excised and cloned into an appropriate expression plasmid. This subcloning can be done by several methods, but is most easily accomplished by PCR amplification of a specific fragment and ligation into an expression plasmid after treating the PCR product with a restriction enzyme or exonuclease to create suitable ends for cloning.

A suitable host cell for expression of a gene can be any procaryotic or eucaryotic cell. For example, an H. pylori polypeptide can be expressed in bacterial cells such as E. coli, insect cells (baculovirus), yeast, or mammalian cells such as Chinese hamster ovary cell (CHO). Other suitable host cells are known to those skilled in the art.

Expression in eucaryotic cells such as mammalian, yeast, or insect cells can lead to partial or complete glycosylation and/or formation of relevant inter- or intra-chain disulfide bonds of a recombinant peptide product. Examples of vectors for expression in yeast S. cerivisae include pYepSecl (Baldari. et al., (1987) Embo J. 6:229-234), pMFa (Kurjan and Herskowitz, (1982) Cell 30:933-943), pJRY88 (Schultz et al., (1987) Gene 54:113-123), and pYES2 (Invitrogen Corporation, San Diego, CA). Baculovirus vectors available for expression of proteins in cultured insect cells (SF 9 cells) include the pAc series (Smith et al., (1983) Mol. Cell Biol. 3:2156-2165) and the pVL series (Lucklow, V.A., and Summers, M.D., (1989) Virology 170:31-39). Generally, COS cells (Gluzman, Y., (1981) Cell 23:175-182) are used in conjunction with such vectors as pCDM 8 (Aruffo, A. and Seed, B., (1987) Proc. Natl. Acad. Sci. USA 84:8573-8577) for transient amplification/expression in mammalian cells, while CHO (dhfr Chinese Hamster Ovary) cells are used with vectors such as pMT2PC (Kaufman et al. (1987), EMBO J. 6:187-195) for stable amplification/expression in mammalian cells. Vector DNA can be introduced into mammalian cells via conventional techniques such as calcium phosphate or calcium chloride co-precipitation, DEAE-dextran-mediated transfection, or electroporation. Suitable methods for transforming host cells can be found in Sambrook et al. (Molecular Cloning: A Laboratory Manual. 2nd Edition, Cold Spring Harbor Laboratory press (1989)), and other laboratory textbooks.

Expression in procaryotes is most often carried out in E. coli with either fusion or non-fusion inducible expression vectors. Fusion vectors usually add a number of NH2 terminal amino acids to the expressed target gene. These NH2 terminal amino acids often are referred to as a reporter group. Such reporter groups usually serve two purposes: 1) to increase the solubility of the target recombinant protein; and 2) to aid in the purification of the target recombinant protein by acting as a ligand in affinity purification. Often, in fusion expression vectors, a proteolytic cleavage site is introduced at the junction of the reporter group and the target recombinant protein to enable separation of the target recombinant protein from the reporter group subsequent to purification of the fusion protein. Such enzymes, and their cognate recognition sequences, include Factor Xa, thrombin and enterokinase. Typical fusion expression vectors include pGEX (Amrad Corp., Melbourne, Australia), pMAL (New England Biolabs, Beverly, MA) and pRIT5 (Pharmacia, Piscataway, NJ) which fuse glutathione S-transferase, maltose E binding protein, or protein A, respectively, to the target recombinant protein. A preferred reporter group is poly(His), which may be fused to the amino or carboxy terminus of the protein and which renders the recombinant fusion protein easily purifiable by metal chelate chromatography.

Inducible non-fusion expression vectors include pTrc (Amann et al., (1988) Gene 69:301-315) and pETl ld (Studier et al.. Gene Expression Technology: Methods in Enzymology 185. Academic Press, San Diego, California (1990) 60-89). While target gene expression relies on host RNA polymerase transcription from the hybrid trp-lac fusion promoter in pTrc, expression of target genes inserted into pETl Id relies on transcription from the T7 gnlO-lac 0 fusion promoter mediated by coexpressed viral RNA polymerase (T7 gnl). This viral polymerase is supplied by host strains BL21(DE3) or HMS174(DE3) from a resident λ prophage harboring a T7 gnl under the transcriptional control of the lacUV 5 promoter.

For example, a host cell transfected with a nucleic acid vector directing expression of a nucleotide sequence encoding an H. pylori polypeptide can be cultured under appropriate conditions to allow expression of the polypeptide to occur. The polypeptide may be secreted and isolated from a mixture of cells and medium containing the peptide. Alternatively, the polypeptide may be retained cytoplasmically and the cells harvested, lysed and the protein isolated. A cell culture includes host cells, media and other byproducts. Suitable media for cell culture are well known in the art. Polypeptides of the invention can be isolated from cell culture medium, host cells, or both using techniques known in the art for purifying proteins including ion-exchange chromatography, gel filtration chromatography, ultrafiltration, electrophoresis, and immunoaffinity purification with antibodies specific for such polypeptides. Additionally, in many situations, polypeptides can be produced by chemical cleavage of a native protein (e.g., tryptic digestion) and the cleavage products can then be purified by standard techniques. In the case of membrane bound proteins, these can be isolated from a host cell by contacting a membrane-associated protein fraction with a detergent forming a solubilized complex, where the membrane-associated protein is no longer entirely embedded in the membrane fraction and is solubilized at least to an extent which allows it to be chromatographically isolated from the membrane fraction. Several different criteria are used for choosing a detergent suitable for solubilizing these complex. For example, one property considered is the ability of the detergent to solubilize the H. pylori protein within the membrane fraction at minimal denaturation of the membrane- associated protein allowing for the activity or functionality of the membrane-associated protein to return upon reconstitution of the protein. Another property considered when selecting the detergent is the critical micells concentration (CMC) of the detergent in that the detergent of choice preferably has a high CMC value allowing for ease of removal after reconstitution. A third property considered when selecting a detergent is the hydrophobicity of the detergent. Typically, membrane-associated proteins are very hydrophobic and therefore detergents which are also hydrophobic, e.g., the triton series, would be useful for solubilizing the hydrophobic proteins. Another property important to a detergent can be the capability of the detergent to remove the H. pylori protein with minimal protein-protein interaction facilitating further purification. A fifth property of the detergent which should be considered is the charge of the detergent. For example, if it is desired to use ion exchange resins in the purification process then preferably detergent should be an uncharged detergent. Chromatographic techniques which can be used in the final purification step are known in the art and include hydrophobic interaction, lectin affinity, ion exchange, dye affinity and immunoaffmity.

One strategy to maximize recombinant H. pylori peptide expression in E. coli is to express the protein in a host bacteria with an impaired capacity to proteolytically cleave the recombinant protein (Gottesman, S., Gene Expression Technology: Methods in Enzymology 185. Academic Press, San Diego, California (1990) 119-128). Another strategy would be to alter the nucleic acid encoding H. pylori peptide to be inserted into an expression vector so that the individual codons for each amino acid would be those preferentially utilized in highly expressed E. coli proteins (Wada et al., (1992) Nuc. Acids Res. 20:2111-2118). Such alteration of nucleic acids of the invention can be carried out by standard DNA synthesis techniques.

The nucleic acids of the invention can also be chemically synthesized using standard techniques. Various methods of chemically synthesizing polydeoxynucleotides are known, including solid-phase synthesis which, like peptide synthesis, has been fully automated in commercially available DNA synthesizers (See, e.g., Itakura et al. U.S. Patent No. 4,598,049; Caruthers et al. U.S. Patent No. 4,458,066; and Itakura U.S. Patent Nos. 4,401,796 and 4,373,071 , incorporated by reference herein).

HI. H. pylori Polypeptides This invention encompasses isolated H. pylori polypeptides encoded by the disclosed H. pylori genomic sequences, including the polypeptides contained in the Sequence Listing. Polypeptides of the invention are preferably at least 5 amino acid residues in length. Using the DNA sequence information provided herein, the amino acid sequences of the polypeptides encompassed by the invention can be deduced using methods well-known in the art. It will be understood that the sequence of an entire nucleic acid encoding an H. pylori polypeptide can be isolatedand identified based on an ORF that endoes only a fragment of the cognate protein-coding region. This can be acheived, for example, by using the isolated nucleic acid encoding the ORF, or fragments thereof, to prime a polymerase chain reaction with genomic H. pylori DNA as template; this is followed by sequencing the amplified product.

The polypeptides of the invention can be isolated from wild-type or mutant H. pylori cells or from heterologous organisms or cells (including, but not limited to, bacteria, yeast, insect, plant and mammalian cells) into which an H. pylori nucleic acid has been introduced and expressed. In addition, the polypeptides can be part of recombinant fusion proteins.

H. pylori polypeptides of the invention can be chemically synthesized using commercially automated procedures such as those referenced herein.

Many of the polypeptides of the invention are related to one another. Some of these relationships are described in Tables 3-6 below. All of the polypeptide lengths in Table 3 are from stop codon to stop codon in the nucleotide sequence of H. pylori. As is known in the art, the actual polypeptide lengths are usually shorter than the stop-to-stop codon lengths because a start codon for an initiator charged tRNA usually appears a few nucleotides downstream from the prior stop codon and within a few nucleotides following a ribosome binding site (also known as a "Shine-Delgarno sequence"). Since most of the ribosome binding sites in H. pylori have many of the same general features of those known in E. coli, one skilled in the art can predict the actual start codon with good reliability from the stop-to-stop nucleotide sequence of an open reading frame. The polypeptide sequences of SEQ ID NOs:492-743 of this invention represent the stop- to-stop codon lengths of the open reading frames of SEQ ID NOs: 1-252. All other polypeptide sequences of this invention represent the predicted start to stop protein lengths from the nucleotide sequences. One skilled in the art can recognize start sites in the stop-to-stop open reading frames of the nucleotide sequences presented herein. In addition, one skilled in the art will occasionally detect alternative start sites, some of which may be utilized in vivo by the cellular machinery. The number of these alternative start sites is sufficiently small that one skilled in the art can readily test them in a recombinant expression systems known in the art to determine which ones provide authentic functional protein products.

The relationship between the polypeptides shown in Table 3 can be described as follows. First, all of the polypeptides of Table 3 are at least 90% identical with each other over most of their lengths, and most are over 95% identical with each other. Second, the stop-to-stop lengths are different for some of the homologous pairs of polypeptides. In some cases, the shorter polypeptide contains the relevant portion of the protein exhibiting utility in this invention; in some cases, the longer polypeptide may exhibit improved utility. Third, some polypeptides in the second column are homologous to two shorter polypeptides in the fifth column. In all cases, the homology relationships described in Table 3 are highly significant. For example, a typical H. pylori gene product will exhibit amino acid sequence identities of between 92% and 100% among different strains of H. pylori selected from human patients. The nucleotide sequences encoding the related polypeptides of this invention are also very similar to one another. For example, nucleotide probes derived from the coding sequence of a polypeptide of this invention can be used in PCR or hybridization experiments to identify clones carrying the nucleotide sequence encoding the homologous related polypeptide.

TABLE 3

TABLE 3 (continued)

TABLE 3 (continued)

TABLE 3 (continued)

Additional relationships between polypeptides of the invention are described in Table 4 below. All of the polypeptide lengths in Table 4 below are measured from stop codon to stop codon in the nucleotide sequence of H. pylori.

The relationship between the polypeptides shown in Table 4 can be described as follows. First, all of the polypeptides of Table 4 are at least 90% identical with each other over most of their lengths, and most are over 95% identical with each other. Second, the stop-to-stop lengths are different for some of the homologous pairs of polypeptides. In some cases, the shorter polypeptide contains the relevant portion of the protein exhibiting utility in this invention; in some cases, the longer polypeptide may exhibit improved utility. Third, some polypeptides in the second column are homologous to two shorter polypeptides in the fifth column.

In all cases, the homology relationships described in Table 4 are highly significant. For example, a typical H. pylori gene product will exhibit amino acid sequence identities of between 92% and 100% among different strains of pylori selected from human patients. The nucleotide sequences encoding the related polypeptides of this invention are also very similar to one another. For example, nucleotide probes derived from the coding sequence of a polypeptide of this invention can be used in PCR or hybridization experiments to identify clones carrying the nucleotide sequence encoding the homologous related polypeptide.

TABLE 4

Additional relationships between polypeptides of the invention are described in Table 5 below. All of the polypeptide lengths in Table5 below are measured from start codon to stop codon in the nucleotide sequence of H pylori. The relationship between the polypeptides shown in Table 5 can be described as follows. First, all of the polypeptides of Table 5 are at least 90% identical with each other over most of their lengths, and most are over 95% identical with each other. Second, the start-to-stop lengths are different for some of the homologous pairs of polypeptides. In some cases, the shorter polypeptide contains the relevant portion of the protein exhibiting utility in this invention; in some cases, the longer polypeptide may exhibit improved utility. Third, some polypeptides in the second column are homologous to two shorter polypeptides in the fifth column.

In all cases, the homology relationships described in Table 5 are highly significant. For example, a typical H. pylori gene product will exhibit amino acid sequence identities of between 92% and 100% among different strains of H. pylori selected from human patients. The nucleotide sequences encoding the related polypeptides of this invention are also very similar to one another. For example, nucleotide probes derived from the coding sequence of a polypeptide of this invention can be used in PCR or hybridization experiments to identify clones carrying the nucleotide sequence encoding the homologous related polypeptide. TABLE 5

υ t

Additional relationships between polypeptides of the invention are described in Table 6 below. All of the polypeptide lengths in Table 6 below are measured from stop codon to stop codon in the nucleotide sequence of H pylori.

The relationship between the polypeptides shown in Table 6 can be described as follows. First, all of the polypeptides of Table 6 are at least 90% identical with each other over most of their lengths, and most are over 95% identical with each other. Second, the stop-to-stop lengths are different for the homologous pairs of polypeptides. In some cases, the shorter polypeptide contains the relevant portion of the protein exhibiting utility in this invention; in some cases, the longer polypeptide may exhibit improved utility.

In all cases, the homology relationships described in Table 6 are highly significant. For example, a typical H. pylori gene product will exhibit amino acid sequence identities of between 92% and 100% among different strains of H. pylori selected from human patients. The nucleotide sequences encoding the related polypeptides of this invention are also very similar to one another. For example, nucleotide probes derived from the coding sequence of a polypeptide of this invention can be used in PCR or hybridization experiments to identify clones carrying the nucleotide sequence encoding the homologous related polypeptide.

TABLE 6 (continued)

< 1

IV. Identification of Nucleic Acids Encoding Vaccine Components and Targets for Agents Effective Against H. pylori

The disclosed H. pylori genome sequence includes segments that direct the synthesis of ribonucleic acids and polypeptides, as well as origins of replication, promoters, other types of regulatory sequences, and intergenic nucleic acids. The invention encompasses the identification of nucleic acids encoding immunogenic components of vaccines and targets for agents effective against H. pylori. An important aspect of this identification is to determine the function of the disclosed sequences, which can be achieved using a variety of approaches. Non-limiting examples of these methods are described briefly below.

Homology to known sequences: Computer-assisted comparison of the disclosed H. pylori sequences with previously reported sequences present in publicly available databases is a useful tool for identifying functional H. pylori nucleic acid and polypeptide sequences. It will be understood that protein-coding sequences, for example, may be compared as a whole, and that a high degree of sequence homology between two proteins (such as, for example, >80-90%) at the amino acid level is strongly suggestive that the two proteins also possess some degree of functional homology, such as, for example, among enzymes involved in metabolism, DNA synthesis, or cell wall synthesis, and proteins involved in transport, cell division, etc. In addition, many structural features of particular protein classes have been identified and correlate with specific consensus sequences, such as, for example, binding domains for nucleotides, DNA, metal ions, and other small molecules; sites for covalent modifications such as phosphorylation, acylation, and the like; sites of protei protein interactions, etc. These consensus sequences may be quite short and thus may represent only a fraction of the entire protein-coding sequence. Identification of such a feature in an H. pylori sequence is therefore useful in determining the function of the encoded protein and identifying potentially useful targets of antibacterial drugs.

Of particular relevance to the present invention are structural features that are common to secretory, transmembrane, and surface proteins, including secretion signal peptides and hydrophobic transmembrane domains. H. pylori proteins identified as containing putative signal sequences and/or transmembrane domains are useful as immunogenic components of vaccines.

Identification of essential genes: Nucleic acids that encode proteins essential for growth or viability of H. pylori are preferred drug targets. H. pylori genes can be tested for their biological relevance to the organism by examining the effect of deleting and/or disrupting the genes, i.e., by so-called gene "knockout", using techniques known to those skilled in the relevant art. In this manner, essential genes may be identified. Strain-specific sequences: Because of the evolutionary relationship between different H. pylori strains, it is believed that the presently disclosed H. pylori sequences are useful for identifying, and/or discriminating between, previously known and new H. pylori strains. It is believed that other H. pylori strains will exhibit at least 70% sequence homology with the presently disclosed sequence, although whether or not this is correct is not essential to the invention. Systematic and routine analyses of DNA sequences derived from samples containing H pylori strains, and comparison with the present sequence allows for the identification of sequences that can be used to discriminate between strains, as well as those that are common to all H pylori strains. In one embodiment, the invention provides nucleic acids, including probes, and peptide and polypeptide sequences that discriminate between different strains of H pylori. Strain-specific components can also be identified functionally by their ability to elicit or react with antibodies that selectively recognize one or more H. pylori strains.

In another embodiment, the invention provides nucleic acids, including probes, and peptide and polypeptide sequences that are common to all H. pylori strains but are not found in other bacterial species.

Specific Example: Determination Of Candidate Protein Antigens For Antibody And Vaccine Development The selection of candidate protein antigens for vaccine development can be derived from the nucleic acids encoding H. pylori polypeptides. First, the ORF's can be analyzed for homology to other known exported or membrane proteins and analyzed using the discriminant analysis described by Klein, et al. (Klein, P., Kanehsia, M., and DeLisi, C. (1985) Biochimica et Biophysica Ada 815, 468-476) for predicting exported and membrane proteins.

Homology searches can be performed using the BLAST algorithm contained in the Wisconsin Sequence Analysis Package (Genetics Computer Group, University Research Park, 575 Science Drive, Madison, WI 53711) to compare each predicted ORF amino acid sequence with all sequences found in the current GenBank, SWISS-PROT and PIR databases. BLAST searches for local alignments between the ORF and the databank sequences and reports a probability score which indicates the probability of finding this sequence by chance in the database. ORF's with significant homology (e.g. probabilities better than 1x10 (ee-6)) to membrane or exported proteins represent likely protein antigens for vaccine development. Possible functions can be provided to H. pylori genes based on sequence homology to genes cloned in other organisms.

Discriminant analysis (Klein, et al. supra) can be used to examine the ORF amino acid sequences. This algorithm uses the intrinsic information contained in the ORF amino acid sequence and compares it to information derived from the properties of known membrane and exported proteins. This comparison predicts which proteins will be exported, membrane associated or cytoplasmic. ORF amino acid sequences identified as exported or membrane associated by this algorithm are likely protein antigens for vaccine development.

Surface exposed outer membrane proteins are likely to represent the best antigens to provide a protective immune response against H. pylori. Among the algorithms that can be used to aid in prediction of these outer membrane proteins include the presence of an amphipathic beta-sheet region at their C-terminus. This region which has been detected in a large number of outer membrane proteins in Gram negative bacteria is often characterized by hydrophobic residues (Phe or Tyr) approximately at positions 1, 3, 5, 7 and 9 from the C-terminus (e.g., see Figure 8, block F). Importantly, these sequences have not been detected at the C-termini of periplasmic proteins, thus allowing preliminary distinction between these classes of proteins based on primary sequence data. This phenomenon has been reported previously by Struyve et al. (J. Mol. Biol. 218:141-148, 1991).

Also illustrated in Figure 8 are additional amino acid sequence motifs found in many outer membrane proteins of H. pylori. The amino acid sequence alignment in Figure 8 depicts portions of the sequence of 12 H. pylori proteins (depicted in the single letter amino acid code) labeled with their amino acid Sequence ID Numbers and shown N-terminal to C-terminal, left to right. Six distinct blocks (labeled A through F) of similar amino acid residues are found including the distinctive hydrophobic residues (Phe or Tyr; F or Y according to the single letter code for amino acid residues) frequently found at positions near the C-terminus of outer membrane proteins. The presence of several shared motifs clearly establishes the similarity between members of this group of proteins.

In addition, outer membrane proteins isolated from H pylori frequently share a motif near the mature N-terminus (i.e., after processing to remove the secretion signal) as illustrated in the blocked amino acid residues in Figure 9. Figure 9 depicts the N- terminal portion of nine H. pylori proteins (designated by their amino acid Sequence ID Numbers and shown N-terminal to C-terminal, left to right).

One skilled in the art would know that these shared sequence motifs are highly significant and establish a similarity among this group of proteins.

Infrequently it is not possible to distinguish between multiple possible nucleotides at a given position in the nucleic acid sequence. In those cases the ambiguities are denoted by an extended alphabet as follows: These are the official IUPAC-IUB single-letter base codes

Code Base Description

G Guanine

A Adenine

T Thymine

C Cytosine

R Purine (A or G)

Y Pyrimidine (C or T or U)

M Amino (A or C)

K Ketone (G or T)

S Strong interaction (C or G)

W Weak interaction (A or T)

H Not-G (A or C or T)

B Not-A (C or G or T)

V Not-T (not-U) (A or C or G)

D Not-C (A or G or T)

N Any (A or C or G or T)

The amino acid translations of this invention account for the ambiguity in the nucleic acid sequence by translating the ambiguous codon as the letter "X". In all cases, the permissible amino acid residues at a position are clear from an examination of the nucleic acid sequence based on the standard genetic code.

V. Production of Fragments and Analogs of H pylori Nucleic Acids and Polypeptides Based on the discovery of the H. pylori gene products provided in the Sequence

Listing, one skilled in the art can alter the disclosed structure (of H. pylori genes), e.g., by producing fragments or analogs, and test the newly produced structures for activity. Examples of techniques known to those skilled in the relevant art which allow the production and testing of fragments and analogs are discussed below. These, or analogous methods can be used to make and screen libraries of polypeptides, e.g., libraries of random peptides or libraries of fragments or analogs of cellular proteins for the ability to bind H. pylori polypeptides. Such screens are useful for discovery of inhibitors of H. pylori.

Generation of Fragments Fragments of a protein can be produced in several ways, e.g., recombinantly, by proteolytic digestion, or by chemical synthesis. Internal or terminal fragments of a polypeptide can be generated by removing one or more nucleotides from one end (for a terminal fragment) or both ends (for an internal fragment) of a nucleic acid which encodes the polypeptide. Expression of the mutagenized DNA produces polypeptide fragments. Digestion with "end-nibbling" endonucleases can thus generate DNA's which encode an array of fragments. DNA's which encode fragments of a protein can also be generated by random shearing, restriction digestion or a combination of the above-discussed methods.

Fragments can also be chemically synthesized using techniques known in the art such as conventional Merrifield solid phase f-Moc or t-Boc chemistry. For example, peptides of the present invention may be arbitrarily divided into fragments of desired length with no overlap of the fragments, or divided into overlapping fragments of a desired length.

Alteration of Nucleic Acids and Polypeptides: Random Methods Amino acid sequence variants of a protein can be prepared by random mutagenesis of DNA which encodes a protein or a particular domain or region of a protein. Useful methods include PCR mutagenesis and saturation mutagenesis. A library of random amino acid sequence variants can also be generated by the synthesis of a set of degenerate oligonucleotide sequences. (Methods for screening proteins in a library of variants are elsewhere herein). (A) PCR Mutagenesis

In PCR mutagenesis, reduced Taq polymerase fidelity is used to introduce random mutations into a cloned fragment of DNA (Leung et al., 1989, Technique 1 :11-15). The DNA region to be mutagenized is amplified using the polymerase chain reaction (PCR) under conditions that reduce the fidelity of DNA synthesis by Taq DNA polymerase, e.g., by using a dGTP/dATP ratio of five and adding Mn2⁺ to the PCR reaction. The pool of amplified DNA fragments are inserted into appropriate cloning vectors to provide random mutant libraries.

(B) Saturation Mutagenesis

Saturation mutagenesis allows for the rapid introduction of a large number of single base substitutions into cloned DNA fragments (Mayers et al., 1985, Science 229:242). This technique includes generation of mutations, e.g., by chemical treatment or irradiation of single-stranded DNA in vitro, and synthesis of a complimentary DNA strand. The mutation frequency can be modulated by modulating the severity of the treatment, and essentially all possible base substitutions can be obtained. Because this procedure does not involve a genetic selection for mutant fragments both neutral substitutions, as well as those that alter function, are obtained. The distribution of point mutations is not biased toward conserved sequence elements.

(C) Degenerate Oligonucleotides

A library of homologs can also be generated from a set of degenerate oligonucleotide sequences. Chemical synthesis of a degenerate sequences can be carried out in an automatic DNA synthesizer, and the synthetic genes then ligated into an appropriate expression vector. The synthesis of degenerate oligonucleotides is known in the art (see for example, Narang, SA (1983) Tetrahedron 39:3; Itakura et al. (1981) Recombinant DNA, Proc 3rd Cleveland Sympos. Macromolecules, ed. AG Walton, Amsterdam: Elsevier pp273-289; Itakura et al. (1984) Annu. Rev. Biochem. 53:323; Itakura et al. (1984) Science 198:1056; Ike et al. (1983) Nucleic Acid Res. 11 :477. Such techniques have been employed in the directed evolution of other proteins (see, for example, Scott et al. (1990) Science 249:386-390; Roberts et al. (1992) PNAS 89:2429- 2433; Devlin et al. (1990) Science 249: 404-406; Cwirla et al. (1990) PNAS 87: 6378- 6382; as well as U.S. Patents Nos. 5,223,409, 5,198,346, and 5,096,815). Alteration of Nucleic Acids and Polypeptides: Methods for Directed Mutagenesis

Non-random or directed, mutagenesis techniques can be used to provide specific sequences or mutations in specific regions. These techniques can be used to create variants which include, e.g., deletions, insertions, or substitutions, of residues of the known amino acid sequence of a protein. The sites for mutation can be modified individually or in series, e.g., by (1) substituting first with conserved amino acids and then with more radical choices depending upon results achieved, (2) deleting the target residue, or (3) inserting residues of the same or a different class adjacent to the located site, or combinations of options 1-3.

(A) Alanine Scanning Mutagenesis Alanine scanning mutagenesis is a useful method for identification of certain residues or regions of the desired protein that are preferred locations or domains for mutagenesis, Cunningham and Wells (Science 244:1081-1085, 1989). In alanine scanning, a residue or group of target residues are identified (e.g., charged residues such as Arg, Asp, His, Lys, and Glu) and replaced by a neutral or negatively charged amino acid (most preferably alanine or polyalanine). Replacement of an amino acid can affect the interaction of the amino acids with the surrounding aqueous environment in or outside the cell. Those domains demonstrating functional sensitivity to the substitutions are then refined by introducing further or other variants at or for the sites of substitution. Thus, while the site for introducing an amino acid sequence variation is predetermined, the nature of the mutation per se need not be predetermined. For example, to optimize the performance of a mutation at a given site, alanine scanning or random mutagenesis may be conducted at the target codon or region and the expressed desired protein subunit variants are screened for the optimal combination of desired activity.

(B) Oligonucleotide-Mediated Mutagenesis Oligonucleotide-mediated mutagenesis is a useful method for preparing substitution, deletion, and insertion variants of DNA, see, e.g., Adelman et al., (DNA 2:183, 1983). Briefly, the desired DNA is altered by hybridizing an oligonucleotide encoding a mutation to a DNA template, where the template is the single-stranded form of a plasmid or bacteriophage containing the unaltered or native DNA sequence of the desired protein. After hybridization, a DNA polymerase is used to synthesize an entire second complementary strand of the template that will thus incorporate the oligonucleotide primer, and will code for the selected alteration in the desired protein DNA. Generally, oligonucleotides of at least 25 nucleotides in length are used. An optimal oligonucleotide will have 12 to 15 nucleotides that are completely complementary to the template on either side of the nucleotide(s) coding for the mutation. This ensures that the oligonucleotide will hybridize properly to the single- stranded DNA template molecule. The oligonucleotides are readily synthesized using techniques known in the art such as that described by Crea et al. (Proc. Natl. Acad. Sci. USA, 75: 5765[1978]).

(C) Cassette Mutagenesis Another method for preparing variants, cassette mutagenesis, is based on the technique described by Wells et al. (Gene, 34:315[1985]). The starting material is a plasmid (or other vector) which includes the protein subunit DNA to be mutated. The codon(s) in the protein subunit DNA to be mutated are identified. There must be a unique restriction endonuclease site on each side of the identified mutation site(s). If no such restriction sites exist, they may be generated using the above-described oligonucleotide-mediated mutagenesis method to introduce them at appropriate locations in the desired protein subunit DNA. After the restriction sites have been introduced into the plasmid, the plasmid is cut at these sites to linearize it. A double-stranded oligonucleotide encoding the sequence of the DNA between the restriction sites but containing the desired mutation(s) is synthesized using standard procedures. The two strands are synthesized separately and then hybridized together using standard techniques. This double-stranded oligonucleotide is referred to as the cassette. This cassette is designed to have 3' and 5' ends that are comparable with the ends of the linearized plasmid, such that it can be directly ligated to the plasmid. This plasmid now contains the mutated desired protein subunit DNA sequence.

(D) Combinatorial Mutagenesis

Combinatorial mutagenesis can also be used to generate mutants (Ladner et al., WO 88/06630). In this method, the amino acid sequences for a group of homologs or other related proteins are aligned, preferably to promote the highest homology possible. All of the amino acids which appear at a given position of the aligned sequences can be selected to create a degenerate set of combinatorial sequences. The variegated library of variants is generated by combinatorial mutagenesis at the nucleic acid level, and is encoded by a variegated gene library. For example, a mixture of synthetic oligonucleotides can be enzymatically ligated into gene sequences such that the degenerate set of potential sequences are expressible as individual peptides, or alternatively, as a set of larger fusion proteins containing the set of degenerate sequences.

Other Modifications of H. pylori Nucleic Acids and Polypeptides It is possible to modify the structure of an H. pylori polypeptide for such purposes as increasing solubility, enhancing stability (e.g., shelf life ex vivo and resistance to proteolytic degradation in vivo). A modified H. pylori protein or peptide can be produced in which the amino acid sequence has been altered, such as by amino acid substitution, deletion, or addition as described herein.

An H pylori peptide can also be modified by substitution of cysteine residues preferably with alanine, serine, threonine, leucine or glutamic acid residues to minimize dimerization via disulfide linkages. In addition, amino acid side chains of fragments of the protein of the invention can be chemically modified. Another modification is cyclization of the peptide.

In order to enhance stability and/or reactivity, an H. pylori polypeptide can be modified to incorporate one or more polymorphisms in the amino acid sequence of the protein resulting from any natural allelic variation. Additionally, D-amino acids, non- natural amino acids, or non-amino acid analogs can be substituted or added to produce a modified protein within the scope of this invention. Furthermore, an H. pylori polypeptide can be modified using polyethylene glycol (PEG) according to the method of A. Sehon and co-workers (Wie et al., supra) to produce a protein conjugated with PEG. In addition, PEG can be added during chemical synthesis of the protein. Other modifications of H. pylori proteins include reduction/alkylation (Tarr, Methods of Protein Microcharacterization, J. E. Silver ed., Humana Press, Clifton NJ 155-194 (1986)); acylation (Tarr, supra); chemical coupling to an appropriate carrier (Mishell and Shiigi, eds, Selected Methods in Cellular Immunology, WH Freeman, San Francisco, CA (1980), U.S. Patent 4,939,239; or mild formalin treatment (Marsh, (1971) Int. Arch, of Allergy andAppl. Immunol, 4J_: 199 - 215).

To facilitate purification and potentially increase solubility of an H. pylori protein or peptide, it is possible to add an amino acid fusion moiety to the peptide backbone. For example, hexa-histidine can be added to the protein for purification by immobilized metal ion affinity chromatography (Hochuli, E. et al., (1988)

Bio/Technology, 6: 1321 - 1325). In addition, to facilitate isolation of peptides free of irrelevant sequences, specific endoprotease cleavage sites can be introduced between the sequences of the fusion moiety and the peptide.

To potentially aid proper antigen processing of epitopes within an H. pylori polypeptide, canonical protease sensitive sites can be engineered between regions, each comprising at least one epitope via recombinant or synthetic methods. For example, charged amino acid pairs, such as KK or RR, can be introduced between regions within a protein or fragment during recombinant construction thereof. The resulting peptide can be rendered sensitive to cleavage by cathepsin and/or other trypsin-like enzymes which would generate portions of the protein containing one or more epitopes. In addition, such charged amino acid residues can result in an increase in the solubility of the peptide.

Primary Methods for Screening Polypeptides and Analogs Various techniques are known in the art for screening generated mutant gene products. Techniques for screening large gene libraries often include cloning the gene library into replicable expression vectors, transforming appropriate cells with the resulting library of vectors, and expressing the genes under conditions in which detection of a desired activity, e.g., in this case, binding to H. pylori polypeptide or an interacting protein, facilitates relatively easy isolation of the vector encoding the gene whose product was detected. Each of the techniques described below is amenable to high through-put analysis for screening large numbers of sequences created, e.g., by random mutagenesis techniques.

(A) Two Hybrid Systems

Two hybrid assays such as the system described above (as with the other screening methods described herein), can be used to identify polypeptides, e.g., fragments or analogs of a naturally-occurring H. pylori polypeptide, e.g., of cellular proteins, or of randomly generated polypeptides which bind to an H. pylori protein. (The H pylori domain is used as the bait protein and the library of variants are expressed as fish fusion proteins.) In an analogous fashion, a two hybrid assay (as with the other screening methods described herein), can be used to find polypeptides which bind a H. pylori polypeptide.

(B) Display Libraries

In one approach to screening assays, the candidate peptides are displayed on the surface of a cell or viral particle, and the ability of particular cells or viral particles to bind an appropriate receptor protein via the displayed product is detected in a "panning assay". For example, the gene library can be cloned into the gene for a surface membrane protein of a bacterial cell, and the resulting fusion protein detected by panning (Ladner et al., WO 88/06630; Fuchs et al. (1991) Bio/Technology 9:1370-1371 ; and Goward et al. (1992) TIBS 18:136-140). In a similar fashion, a detectably labeled ligand can be used to score for potentially functional peptide homologs. Fluorescently labeled ligands, e.g., receptors, can be used to detect homolog which retain ligand- binding activity. The use of fluorescently labeled ligands, allows cells to be visually inspected and separated under a fluorescence microscope, or, where the morphology of the cell permits, to be separated by a fluorescence-activated cell sorter.

A gene library can be expressed as a fusion protein on the surface of a viral particle. For instance, in the filamentous phage system, foreign peptide sequences can be expressed on the surface of infectious phage, thereby conferring two significant benefits. First, since these phage can be applied to affinity matrices at concentrations well over 10^ phage per milliliter, a large number of phage can be screened at one time. Second, since each infectious phage displays a gene product on its surface, if a particular phage is recovered from an affinity matrix in low yield, the phage can be amplified by another round of infection. The group of almost identical E. coli filamentous phages M13, fd., and fl are most often used in phage display libraries. Either of the phage gill or gVIII coat proteins can be used to generate fusion proteins without disrupting the ultimate packaging of the viral particle. Foreign epitopes can be expressed at the NH2- terminal end of pill and phage bearing such epitopes recovered from a large excess of phage lacking this epitope (Ladner et al. PCT publication WO 90/02909; Garrard et al., PCT publication WO 92/09690; Marks et al. (1992) J. Biol. Chem. 267:16007-16010; Griffiths et al. (1993) EMBO J 12:725-734; Clackson et al. (1991) Nature 352:624-628; and Barbas et al. (1992) PNAS 89:4457-4461).

A common approach uses the maltose receptor of E. coli (the outer membrane protein, LamB) as a peptide fusion partner (Charbit et al. (1986) EMBO 5, 3029-3037). Oligonucleotides have been inserted into plasmids encoding the LamB gene to produce peptides fused into one of the extracellular loops of the protein. These peptides are available for binding to ligands, e.g., to antibodies, and can elicit an immune response when the cells are administered to animals. Other cell surface proteins, e.g., OmpA (Schorr et al. (1991) Vaccines 91, pp. 387-392), PhoE (Agterberg, et al. (1990) Gene 88, 37-45), and PAL (Fuchs et al. (1991) Bio/Tech 9, 1369-1372), as well as large bacterial surface structures have served as vehicles for peptide display. Peptides can be fused to pilin, a protein which polymerizes to form the pilus-a conduit for interbacterial exchange of genetic information (Thiry et al. (\989) Appl Environ. Microbiol. 55, 984-993). Because of its role in interacting with other cells, the pilus provides a useful support for the presentation of peptides to the extracellular environment. Another large surface structure used for peptide display is the bacterial motive organ, the flagellum. Fusion of peptides to the subunit protein flagellin offers a dense array of may peptides copies on the host cells (Kuwajima et al. (1988) Bio/Tech. 6, 1080-1083). Surface proteins of other bacterial species have also served as peptide fusion partners. Examples include the Staphylococcus protein A and the outer membrane protease IgA of Neisseria (Hansson et al. (1992) J. Bacteriol. 174, 4239-4245 and Klauser et al. (1990) EMBO J. 9, 1991- 1999).

In the filamentous phage systems and the LamB system described above, the physical link between the peptide and its encoding DNA occurs by the containment of the DNA within a particle (cell or phage) that carries the peptide on its surface.

Capturing the peptide captures the particle and the DNA within. An alternative scheme uses the DNA-binding protein Lad to form a link between peptide and DNA (Cull et al. (1992) PNAS USA 89:1865-1869). This system uses a plasmid containing the Lad gene with an oligonucleotide cloning site at its 3 '-end. Under the controlled induction by arabinose, a Lad -peptide fusion protein is produced. This fusion retains the natural ability of Lad to bind to a short DNA sequence known as LacO operator (LacO). By installing two copies of LacO on the expression plasmid, the Lacl-peptide fusion binds tightly to the plasmid that encoded it. Because the plasmids in each cell contain only a single oligonucleotide sequence and each cell expresses only a single peptide sequence, the peptides become specifically and stably associated with the DNA sequence that directed its synthesis. The cells of the library are gently lysed and the peptide-DNA complexes are exposed to a matrix of immobilized receptor to recover the complexes containing active peptides. The associated plasmid DNA is then reintroduced into cells for amplification and DNA sequencing to determine the identity of the peptide ligands. As a demonstration of the practical utility of the method, a large random library of dodecapeptides was made and selected on a monoclonal antibody raised against the opioid peptide dynorphin B. A cohort of peptides was recovered, all related by a consensus sequence corresponding to a six-residue portion of dynorphin B. (Cull et al. (1992) Proc. Natl. Acad. Sci. U.S.A. 89-1869) This scheme, sometimes referred to as peptides-on-plasmids, differs in two important ways from the phage display methods. First, the peptides are attached to the C-terminus of the fusion protein, resulting in the display of the library members as peptides having free carboxy termini. Both of the filamentous phage coat proteins, pill and pVIII, are anchored to the phage through their C-termini, and the guest peptides are placed into the outward-extending N-terminal domains. In some designs, the phage- displayed peptides are presented right at the amino terminus of the fusion protein. (Cwirla, et al. (1990) Proc. Natl. Acad. Sci. U.S.A. 87, 6378-6382) A second difference is the set of biological biases affecting the population of peptides actually present in the libraries. The Lad fusion molecules are confined to the cytoplasm of the host cells. The phage coat fusions are exposed briefly to the cytoplasm during translation but are rapidly secreted through the inner membrane into the periplasmic compartment, remaining anchored in the membrane by their C-terminal hydrophobic domains, with the N-termini, containing the peptides, protruding into the periplasm while awaiting assembly into phage particles. The peptides in the Lad and phage libraries may differ significantly as a result of their exposure to different proteolytic activities. The phage coat proteins require transport across the inner membrane and signal peptidase processing as a prelude to incorporation into phage. Certain peptides exert a deleterious effect on these processes and are underrepresented in the libraries (Gallop et al. (1994) J. Med. Chem. 37(9): 1233-1251). These particular biases are not a factor in the Lad display system. The number of small peptides available in recombinant random libraries is enormous. Libraries of 10^-10^ independent clones are routinely prepared. Libraries as large as 10^ 1 recombinants have been created, but this size approaches the practical limit for clone libraries. This limitation in library size occurs at the step of transforming the DNA containing randomized segments into the host bacterial cells. To circumvent this limitation, an in vitro system based on the display of nascent peptides in polysome complexes has recently been developed. This display library method has the potential of producing libraries 3-6 orders of magnitude larger than the currently available phage/phagemid or plasmid libraries. Furthermore, the construction of the libraries, expression of the peptides, and screening, is done in an entirely cell-free format. In one application of this method (Gallop et al. (1994) J. Med. Chem.

37(9):1233-1251), a molecular DNA library encoding 10^ decapeptides was constructed and the library expressed in an E. coli S30 in vitro coupled transcription/translation system. Conditions were chosen to stall the ribosomes on the mRNA, causing the accumulation of a substantial proportion of the RNA in polysomes and yielding complexes containing nascent peptides still linked to their encoding RNA. The polysomes are sufficiently robust to be affinity purified on immobilized receptors in much the same way as the more conventional recombinant peptide display libraries are screened. RNA from the bound complexes is recovered, converted to cDNA, and amplified by PCR to produce a template for the next round of synthesis and screening. The polysome display method can be coupled to the phage display system. Following several rounds of screening, cDNA from the enriched pool of polysomes was cloned into a phagemid vector. This vector serves as both a peptide expression vector, displaying peptides fused to the coat proteins, and as a DNA sequencing vector for peptide identification. By expressing the polysome-derived peptides on phage, one can either continue the affinity selection procedure in this format or assay the peptides on individual clones for binding activity in a phage ELISA, or for binding specificity in a completion phage ELISA (Barret, et al. (1992) Anal. Biochem 204,357-364). To identify the sequences of the active peptides one sequences the DNA produced by the phagemid host.

Secondary Screening of Polypeptides and Analogs The high through-put assays described above can be followed by secondary screens in order to identify further biological activities which will, e.g., allow one skilled in the art to differentiate agonists from antagonists. The type of a secondary screen used will depend on the desired activity that needs to be tested. For example, an assay can be developed in which the ability to inhibit an interaction between a protein of interest and its respective ligand can be used to identify antagonists from a group of peptide fragments isolated though one of the primary screens described above.

Therefore, methods for generating fragments and analogs and testing them for activity are known in the art. Once the core sequence of interest is identified, it is routine to perform for one skilled in the art to obtain analogs and fragments. Peptide Mimetics of H pylori Polypeptides

The invention also provides for reduction of the protein binding domains of the subject H pylori polypeptides to generate mimetics, e.g. peptide or non-peptide agents. The peptide mimetics are able to disrupt binding of a polypeptide to its counter ligand, e.g., in the case of an H pylori polypeptide binding to a naturally occurring ligand. The critical residues of a subject H. pylori polypeptide which are involved in molecular recognition of a polypeptide can be determined and used to generate H. /y/orz^'-derived peptidomimetics which competitively or noncompetitively inhibit binding of the H. pylori polypeptide with an interacting polypeptide (see, for example, European patent applications EP-412,762A and EP-B31,080A). For example, scanning mutagenesis can be used to map the amino acid residues of a particular H. pylori polypeptide involved in binding an interacting polypeptide, peptidomimetic compounds (e.g. diazepine or isoquinoline derivatives) can be generated which mimic those residues in binding to an interacting polypeptide, and which therefore can inhibit binding of an H. pylori polypeptide to an interacting polypeptide and thereby interfere with the function of H. pylori polypeptide. For instance, non- hydrolyzable peptide analogs of such residues can be generated using benzodiazepine (e.g., see Freidinger et al. in Peptides: Chemistry and Biology, G.R. Marshall ed., ESCOM Publisher: Leiden, Netherlands, 1988), azepine (e.g., see Huffman et al. in Peptides: Chemistry and Biology, G.R. Marshall ed., ESCOM Publisher: Leiden, Netherlands, 1988), substituted gama lactam rings (Garvey et al. in Peptides: Chemistry and Biology, G.R. Marshall ed., ESCOM Publisher: Leiden, Netherlands, 1988), keto- methylene pseudopeptides (Ewenson et al. (1986) J Med Chem 29:295; and Ewenson et al. in Peptides: Structure and Function (Proceedings of the 9th American Peptide Symposium) Pierce Chemical Co. Rockland, IL, 1985), β-turn dipeptide cores (Nagai et al. (1985) Tetrahedron Lett 26:647; and Sato et al. (1986) J Chem Soc Perkin Trans 1 :1231), and β-aminoalcohols (Gordon et al. ( 1985) Biochem Biophys Res

Commun\26:4\9; and Dann et al. (1986) Biochem Biophys Res Commun 134:71).

VI. Vaccine Formulations for H. pylori Nucleic Acids and Polypeptides

This invention also features vaccine compositions for protection against infection by H. pylori or for treatment of H. pylori infection, a gram-negative spiral microaerophilic bacterium. In one embodiment, the vaccine compositions contain one or more immunogenic components such as a surface protein from H. pylori, or portion thereof, and a pharmaceutically acceptable carrier. Nucleic acids within the scope of the invention are exemplified by the nucleic acids shown in the Sequence Listing which encode H. pylori surface proteins. However, any nucleic acid encoding an immunogenic H. pylori protein, or portion thereof, which is capable of expression in a cell, can be used in the present invention. These vaccines have therapeutic and prophylactic utilities.

One aspect of the invention provides a vaccine composition for protection against infection by H. pylori which contains at least one immunogenic fragment of an H. pylori protein and a pharmaceutically acceptable carrier. Preferred fragments include peptides of at least about 10 amino acid residues in length, preferably about 10-20 amino acid residues in length, and more preferably about 12-16 amino acid residues in length.

Immunogenic components of the invention can be obtained, for example, by screening polypeptides recombinantly produced from the corresponding fragment of the nucleic acid encoding the full-length H. pylori protein. In addition, fragments can be chemically synthesized using techniques known in the art such as conventional Merrifield solid phase f-Moc or t-Boc chemistry.

In one embodiment, immunogenic components are identified by the ability of the peptide to stimulate T cells. Peptides which stimulate T cells, as determined by, for example, T cell proliferation or cytokine secretion are defined herein as comprising at least one T cell epitope. T cell epitopes are believed to be involved in initiation and perpetuation of the immune response to the protein allergen which is responsible for the clinical symptoms of allergy. These T cell epitopes are thought to trigger early events at the level of the T helper cell by binding to an appropriate HLA molecule on the surface of an antigen presenting cell, thereby stimulating the T cell subpopulation with the relevant T cell receptor for the epitope. These events lead to T cell proliferation, lymphokine secretion, local inflammatory reactions, recruitment of additional immune cells to the site of antigen/T cell interaction, and activation of the B cell cascade, leading to the production of antibodies. A T cell epitope is the basic element, or smallest unit of recognition by a T cell receptor, where the epitope comprises amino acids essential to receptor recognition (e.g., approximately 6 or 7 amino acid residues). Amino acid sequences which mimic those of the T cell epitopes are within the scope of this invention.

In another embodiment, immunogenic components of the invention are identified through genomic vaccination. The basic protocol is based on the idea that expression libraries consisting of all or parts of a pathogen genome, e.g., an H. pylori genome, can confer protection when used to genetically immunize a host. This expression library immunization (ELI) is analogous to expression cloning and involves reducing a genomic expression library of a pathogen, e.g., H. pylori, into plasmids that can act as genetic vaccines. The plasmids can also be designed to encode genetic adjuvants which can dramatically stimulate the humoral response. These genetic adjuvants can be introduced at remote sites and act as well extracelluraly as intracellularly.

This is a new approach to vaccine production that has many of the advantages of live/attenuated pathogens but no risk of infection. An expression library of pathogen DNA is used to immunize a host thereby producing the effects of antigen presentation of a live vaccine without the risk. For example, in the present invention, random fragments from the H. pylori genome or from cosmid or plasmid clones, as well as PCR products from genes identified by genomic sequencing, can be used to immunize a host. The feasibility of this approach has been demonstrated with Mycoplasma pulmonis (Barry et al., Nature 377:632-635, 1995), where even partial expression libraries of Mycoplasma pulmonis, a natural pathogen in rodents, provided protection against challenge from the pathogen.

ELI is a technique that allows for production of a non-infectious multipartite vaccine, even when little is known about pathogen's biology, because ELI uses the immune system to screen candidate genes. Once isolated, these genes can be used as genetic vaccines or for development of recombinant protein vaccines. Thus, ELI allows for production of vaccines in a systematic, largely mechanized fashion. Screening immunogenic components can be accomplished using one or more of several different assays. For example, in vitro, peptide T cell stimulatory activity is assayed by contacting a peptide known or suspected of being immunogenic with an antigen presenting cell which presents appropriate MHC molecules in a T cell culture. Presentation of an immunogenic H pylori peptide in association with appropriate MHC molecules to T cells in conjunction with the necessary costimulation has the effect of transmitting a signal to the T cell that induces the production of increased levels of cytokines, particularly of interleukin-2 and interleukin-4. The culture supernatant can be obtained and assayed for interleukin-2 or other known cytokines. For example, any one of several conventional assays for interleukin-2 can be employed, such as the assay described in Proc. Natl. Acad. Sci USA, 86: 1333 (1989) the pertinent portions of which are incorporated herein by reference. A kit for an assay for the production of interferon is also available from Genzyme Corporation (Cambridge, MA).

Alternatively, a common assay for T cell proliferation entails measuring tritiated thymidine incorporation. The proliferation of T cells can be measured in vitro by determining the amount of ^H-labeled thymidine incorporated into the replicating DNA of cultured cells. Therefore, the rate of DNA synthesis and, in turn, the rate of cell division can be quantified.

Vaccine compositions of the invention containing immunogenic components (e.g., H pylori polypeptide or fragment thereof or nucleic acid encoding an H. pylori polypeptide or fragment thereof) preferably include a pharmaceutically acceptable carrier. The term "pharmaceutically acceptable carrier" refers to a carrier that does not cause an allergic reaction or other untoward effect in patients to whom it is administered. Suitable pharmaceutically acceptable carriers include, for example, one or more of water, saline, phosphate buffered saline, dextrose, glycerol, ethanol and the like, as well as combinations thereof. Pharmaceutically acceptable carriers may further comprise minor amounts of auxiliary substances such as wetting or emulsifying agents, preservatives or buffers, which enhance the shelf life or effectiveness of the antibody. For vaccines of the invention containing H pylori polypeptides, the polypeptide is coadministered with a suitable adjuvant.

It will be apparent to those of skill in the art that the therapeutically effective amount of DNA or protein of this invention will depend, inter alia, upon the administration schedule, the unit dose of antibody administered, whether the protein or DNA is administered in combination with other therapeutic agents, the immune status and health of the patient, and the therapeutic activity of the particular protein or DNA. Vaccine compositions are conventionally administered parenterally, e.g., by injection, either subcutaneously or intramuscularly. Methods for intramuscular immunization are described by Wolff et al. (1990) Science 247: 1465-1468 and by Sedegah et al. (1994) Immunology 91 9866-9870. Other modes of administration include oral and pulmonary formulations, suppositories, and transdermal applications. Oral immunization is preferred over parenteral methods for inducing protection against infection by H. pylori. Czinn et. al. (1993) Vaccine 11 : 637-642. Oral formulations include such normally employed excipients as, for example, pharmaceutical grades of mannitol, lactose, starch, magnesium stearate, sodium saccharine, cellulose, magnesium carbonate, and the like.

The vaccine compositions of the invention can include an adjuvant, including, but not limited to aluminum hydroxide; N-acetyl-muramyl~L-threonyl-D-isoglutamine (thr-MDP); N-acetyl-nor-muramyl-L-alanyl-D-isoglutamine (CGP 11637, referred to as nor-MDP); N-acetylmuramyl-L-alanyl-D-isoglutaminyl-L-alanine-2-(r-2'-dipalmitoyl- sn-glycero-3-hydroxyphos-phoryloxy)-ethylamine (CGP 19835A, referred to a MTP- PE); RIBI, which contains three components from bacteria; monophosphoryl lipid A; trehalose dimycoloate; cell wall skeleton (MPL + TDM + CWS) in a 2% squalene/Tween 80 emulsion; and cholera toxin. Others which may be used are non- toxic derivatives of cholera toxin, including its B subunit, and/or conjugates or genetically engineered fusions of the H. pylori polypeptide with cholera toxin or its B subunit, procholeragenoid, fungal polysaccharides, including schizophyllan, muramyl dipeptide, muramyl dipeptide derivatives, phorbol esters, labile toxin of E. coli, non-H. pylori bacterial lysates, block polymers or saponins.

Other suitable delivery methods include biodegradable microcapsules or immuno-stimulating complexes (ISCOMs) or liposomes, genetically engineered attenuated live vectors such as viruses or bacteria, and recombinant (chimeric) virus-like particles, e.g., bluetongue. The amount of adjuvant employed will depend on the type of adjuvant used. For example, when the mucosal adjuvant is cholera toxin, it is suitably used in an amount of 5 μg to 50 μg, for example 10 μg to 35 μg. When used in the form of microcapsules, the amount used will depend on the amount employed in the matrix of the microcapsule to achieve the desired dosage. The determination of this amount is within the skill of a person of ordinary skill in the art.

Carrier systems in humans may include enteric release capsules protecting the antigen from the acidic environment of the stomach, and including H. pylori polypeptide in an insoluble form as fusion proteins. Suitable carriers for the vaccines of the invention are enteric coated capsules and polylactide-glycolide microspheres. Suitable diluents are 0.2 N NaHCO3 and/or saline.

Vaccines of the invention can be administered as a primary prophylactic agent in adults or in children, as a secondary prevention, after successful eradication of H. pylori in an infected host, or as a therapeutic agent in the aim to induce an immune response in a susceptible host to prevent infection by H. pylon. The vaccines of the invention are administered in amounts readily determined by persons of ordinary skill in the art. Thus, for adults a suitable dosage will be in the range of 10 μg to 10 g, preferably 10 μg to 100 mg, for example 50 μg to 50 mg. A suitable dosage for adults will also be in the range of 5 μg to 500 mg. Similar dosage ranges will be applicable for children. Those skilled in the art will recognize that the optimal dose may be more or less depending upon the patient's body weight, disease, the route of administration, and other factors. Those skilled in the art will also recognize that appropriate dosage levels can be obtained based on results with known oral vaccines such as, for example, a vaccine based on an E. coli lysate (6 mg dose daily up to total of 540 mg) and with an enterotoxigenic E. coli purified antigen (4 doses of 1 mg) (Schulman et al., J. Urol 150:917-921 (1993); Boedecker et al. , American Gastroenterological Assoc. 999:A-222 (1993)). The number of doses will depend upon the disease, the formulation, and efficacy data from clinical trials. Without intending any limitation as to the course of treatment, the treatment can be administered over 3 to 8 doses for a primary immunization schedule over 1 month (Boedeker, American Gastroenterological Assoc. 888:A-222 (1993)).

It will be apparent to those skilled in the art that some of the vaccine compositions of the invention are usefuls only for preventing H. pylori infection, some are useful only for treating H. pylori infection, and some are useful for both preventing and treating H. pylori infection. In a preferred embodiment, the vaccine composition of the invention provides protection against H. pylori infection by stimulating humoral and/or cell-mediated immunity against H pylori. It should be understood that amelioration of any of the symptoms of H. pylori infection is a desirable clinical goal, including a lessening of the dosage of medication used to treat H. pylori-caused disease.

VII. Antibodies Reactive With H pylori Polypeptides

The invention also includes antibodies specifically reactive with the subject H pylori polypeptide. Anti-protein anti-peptide antisera or monoclonal antibodies can be made by standard protocols (See, for example, Antibodies: A Laboratory Manual ed. by Harlow and Lane (Cold Spring Harbor Press: 1988)). A mammal such as a mouse, a hamster or rabbit can be immunized with an immunogenic form of the peptide. Techniques for conferring immunogenicity on a protein or peptide include conjugation to carriers or other techniques well known in the art. An immunogenic portion of the subject H. pylori polypeptide can be administered in the presence of adjuvant. The progress of immunization can be monitored by detection of antibody titers in plasma or serum. Standard ELISA or other immunoassays can be used with the immunogen as antigen to assess the levels of antibodies.

In a preferred embodiment, the subject antibodies are immunospecific for antigenic determinants of the H. pylori polypeptides of the invention, e.g. antigenic determinants of a polypeptide shown in the Sequence Listing, or a closely related human or non-human mammalian homolog (e.g., 90% homologous, more preferably at least 95% homologous). In yet a further preferred embodiment of the invention, the anti-H. pylori antibodies do not substantially cross react (i.e., react specifically) with a protein which is for example, less than 80% percent homologous to a sequence shown in the Sequence Listing. By "not substantially cross react", it is meant that the antibody has a binding affinity for a non-homologous protein which is less than 10 percent, more preferably less than 5 percent, and even more preferably less than 1 percent, of the binding affinity for a protein contained in the Sequence Listing. In a most preferred embodiment, there is no crossreactivity between bacterial and mammalian antigens. The term antibody as used herein is intended to include fragments thereof which are also specifically reactive with H pylori polypeptides. Antibodies can be fragmented using conventional techniques and the fragments screened for utility in the same manner as described above for whole antibodies. For example, F(ab')2 fragments can be generated by treating antibody with pepsin. The resulting F(ab')2 fragment can be treated to reduce disulfide bridges to produce Fab' fragments. The antibody of the invention is further intended to include bispecific and chimeric molecules having an anti-H. pylori portion.

Both monoclonal and polyclonal antibodies (Ab) directed against H. pylori polypeptides or H. pylori polypeptide variants, and antibody fragments such as Fab' and F(ab^')2- can be used to block the action of H. pylori polypeptide and allow the study of the role of a particular H. pylori polypeptide of the invention in aberrant or unwanted intracellular signaling, as well as the normal cellular function of the H. pylori and by microinjection of anti-H. pylori polypeptide antibodies of the present invention. Antibodies which specifically bind H. pylori epitopes can also be used in immunohistochemical staining of tissue samples in order to evaluate the abundance and pattern of expression of H. pylori antigens. Anti H. pylori polypeptide antibodies can be used diagnostically in immuno-precipitation and immuno-blotting to detect and evaluate H. pylori levels in tissue or bodily fluid as part of a clinical testing procedure. Likewise, the ability to monitor H. pylori polypeptide levels in an individual can allow determination of the efficacy of a given treatment regimen for an individual afflicted with such a disorder. The level of an H. pylori polypeptide can be measured in cells found in bodily fluid, such as in urine samples or can be measured in tissue, such as produced by gastric biopsy. Diagnostic assays using anti-H. pylori antibodies can include, for example, immunoassays designed to aid in early diagnosis of H. pylori infections. The present invention can also be used as a method of detecting antibodies contained in samples from individuals infected by this bacterium using specific H. pylori antigens.

Another application of anti-H. pylori polypeptide antibodies of the invention is in the immunological screening of cDN A libraries constructed in expression vectors such as λgtl 1, λgtl8-23, λZAP, and λORF8. Messenger libraries of this type, having coding sequences inserted in the correct reading frame and orientation, can produce fusion proteins. For instance, λgtl 1 will produce fusion proteins whose amino termini consist of β-galactosidase amino acid sequences and whose carboxy termini consist of a foreign polypeptide. Antigenic epitopes of a subject H. pylori polypeptide can then be detected with antibodies, as, for example, reacting nitrocellulose filters lifted from infected plates with anti-H. pylori polypeptide antibodies. Phage, scored by this assay, can then be isolated from the infected plate. Thus, the presence of H. pylori gene homologs can be detected and cloned from other species, and alternate isoforms (including splicing variants) can be detected and cloned.

VIII. Kits Containing Nucleic Acids. Polypeptides or Antibodies of the Invention

The nucleic acid, polypeptides and antibodies of the invention can be combined with other reagents and articles to form kits. Kits for diagnostic purposes typically comprise the nucleic acid, polypeptides or antibodies in vials or other suitable vessels. Kits typically comprise other reagents for performing hybridization reactions, polymerase chain reactions (PCR), or for reconstitution of lyophilized components, such as aqueous media, salts, buffers, and the like. Kits may also comprise reagents for sample processing such as detergents, chaotropic salts and the like. Kits may also comprise immobilization means such as particles, supports, wells, dipsticks and the like. Kits may also comprise labeling means such as dyes, developing reagents, radioisotopes, fluorescent agents, luminescent or chemiluminescent agents, enzymes, intercalating agents and the like. With the nucleic acid and amino acid sequence information provided herein, individuals skilled in art can readily assemble kits to serve their particular purpose. Kits further can include instructions for use.

IX. Drug Screening Assays Using H. pylori Polypeptides By making available purified and recombinant H. pylori polypeptides, the present invention provides assays which can be used to screen for drugs which are either agonists or antagonists of the normal cellular function, in this case, of the subject H. pylori polypeptides, or of their role in intracellular signaling. Such inhibitors or potentiators may be useful as new therapeutic agents to combat H. pylori infections in humans. A variety of assay formats will suffice and, in light of the present inventions, will be comprehended by the skilled artisan.

In many drug screening programs which test libraries of compounds and natural extracts, high throughput assays are desirable in order to maximize the number of compounds surveyed in a given period of time. Assays which are performed in cell-free systems, such as may be derived with purified or semi-purified proteins, are often preferred as "primary" screens in that they can be generated to permit rapid development and relatively easy detection of an alteration in a molecular target which is mediated by a test compound. Moreover, the effects of cellular toxicity and/or bioavailability of the test compound can be generally ignored in the in vitro system, the assay instead being focused primarily on the effect of the drug on the molecular target as may be manifest in an alteration of binding affinity with other proteins or change in enzymatic properties of the molecular target. Accordingly, in an exemplary screening assay of the present invention, the compound of interest is contacted with an isolated and purified H. pylori polypeptide. Screening assays can be constructed in vitro with a purified H. pylori polypeptide or fragment thereof, such as an H. pylori polypeptide having enzymatic activity, such that the activity of the polypeptide produces a detectable reaction product. The efficacy of the compound can be assessed by generating dose response curves from data obtained using various concentrations of the test compound. Moreover, a control assay can also be performed to provide a baseline for comparison. Suitable products include those with distinctive absorption, fluorescence, or chemi-luminescence properties, for example, because detection may be easily automated. A variety of synthetic or naturally occurring compounds can be tested in the assay to identify those which inhibit or potentiate the activity of the H. pylori polypeptide. Some of these active compounds may directly, or with chemical alterations to promote membrane permeability or solubility, also inhibit or potentiate the same activity (e.g., enzymatic activity) in whole, live H. pylori cells.

This invention is further illustrated by the following examples which should not be construed as limiting. The contents of all references and published patent applications cited throughout this application are hereby incorporated by reference.

Other Embodiments

Many of the nucleic acids and corresponding polypeptides of the invention were disclosed previously in the parent applications, U.S.S.N. 08/761,318, filed December 6, 1996 (Attorney Docket No.: GTN-009CP2), U.S.S.N. 08/736,905, filed October 25,

1996 (Attorney Docket No.: GTN-OIOCP) and U.S.S.N. 08/738,859, filed October 28,

1996 (Attorney Docket No.: GTN-009CP), which are a continuation-in-part of U.S.S.N.

08/625,811, filed March 29, 1996 (Attorney Docket No.: GTN-009), and U.S.S.N.

08/758,731, filed April 2, 1996 (Attorney Docket No.: GTN-010). The correlation between sequence identification numbers in the above-identified parent applications and sequence identification numbers provided herein is outlined in Table 7 below.

. J -

EXEMPLIFICATION

I. Cloning and Sequencing of H. pylori DNA

H. pylori chromosomal DNA was isolated according to a basic DNA protocol outlined in Schleif R.F. and Wensink P.C., Practical Methods in Molecular Biology, p.98, Springer- Verlag, NY., 1981, with minor modifications. Briefly, cells were pelleted, resuspended in TE (10 mM Tris, 1 mM EDTA, pΗ 7.6) and GES lysis buffer (5.1 M guanidium thiocyanate, 0.1 M EDTA, pΗ 8.0, 0.5% N-laurylsarcosine) was added. Suspension was chilled and ammonium acetate (NΗ₄Ac) was added to final concentration of 2.0 M. DNA was extracted, first with chloroform, then with phenol- chloroform, and reextracted with chloroform. DNA was precipitated with isopropanol, washed twice with 70% EtOH, dried and resuspended in TE. Following isolation whole genomic H. pylori DNA was nebulized (Bodenteich et al., Automated DNA Sequencing and Analysis (J.C. Venter, ed.), Academic Press, 1994) to a median size of 2000 bp. After nebulization, the DNA was concentrated and separated on a standard 1% agarose gel. Several fractions, corresponding to approximate sizes 900-1300 bp, 1300-1700 bp, 1700-2200 bp, 2200-2700 bp, were excised from the gel and purified by the GeneClean procedure (Bio 101 , Inc.).

The purified DNA fragments were then blunt-ended using T4 DNA polymerase. The healed DNA was then ligated to unique BstXI-linker adopters in 100-1000 fold molar excess. These linkers are complimentary to the BstXI-cut pMPX vectors, while the overhang is not self-complimentary. Therefore, the linkers will not concatemerize nor will the cut-vector religate itself easily. The linker-adopted inserts were separated from the unincorporated linkers on a 1% agarose gel and purified using GeneClean. The linker-adopted inserts were then ligated to each of the 20 pMPX vectors to construct a series of "shotgun" subclone libraries. The vectors contain an out-of-frame lacZ gene at the cloning site which becomes in-frame in the event that an adapter-dimer is cloned, allowing these to be avoided by their blue-color.

All subsequent steps were based on the multiplex DNA sequencing protocols outlined in Church G.M. and Kieffer-Higgins S., Science 240:185-188, 1988. Only major modifications to the protocols are highlighted. Briefly, each of the 20 vectors was then transformed into DH5α competent cells (Gibco/BRL, DH5α transformation protocol). The libraries were assessed by plating onto antibiotic plates containing ampicillin, methicillin and IPTG/Xgal. The plates were incubated overnight at 37°C. Successful transformants were then used for plating of clones and pooling into the multiplex pools. The clones were picked and pooled into 40 ml growth medium cultures. The cultures were grown overnight at 37°C. DNA was purified using the Qiagen Midi-prep kits and Tip- 100 columns (Qiagen, Inc.). In this manner, 100 μg of DNA was obtained per pool. 15 96-well plates of DNA were generated to obtain a 5-10 fold sequence redundancy with 250-300 base average read-lengths. These purified DNA samples were then sequenced using the multiplex DNA sequencing based on chemical degradation methods (Church G.M. and Kieffer-Higgins S., Science 240:185-188, 1988) or by Sequithrem (Epicenter Technologies) dideoxy sequencing protocols. The sequencing reactions were electrophoresed and transferred onto nylon membranes by direct transfer electrophoresis from 40 cm gels (Richterich P. and Church G.M., Methods in Enzemology 218:187-222, 1993) or by electroblotting

(Church, supra). 24 samples were run per gel. 45 successful membranes were produced by chemical sequencing and 8 were produced by dideoxy sequencing. The DNA was covalently bound to the membranes by exposure to ultraviolet light, and hybridized with labeled oligonucleotides complimentary to tag sequences on the vectors (Church, supra). The membranes were washed to rinse off non-specifically bound probe, and exposed to X-ray film to visualize individual sequence ladders. After autoradiography, the hybridized probe was removed by incubation at 65° C, and the hybridization cycle repeated with another tag sequence until the membrane has been probed 38 times for chemical sequencing membranes and 10 times for the dideoxy sequencing membranes. Thus, each gel produced a large number of films, each containing new sequencing information. Whenever a new blot was processed, it was initially probed for an internal standard sequence added to each of the pools.

Digital images of the films were generated using a laser-scanning densitometer (Molecular Dynamics, Sunnyvale, CA). The digitized images were processed on computer workstations (VaxStation 4000's) using the program REPLICA™ (Church et al., Automated DNA Sequenicng and Analysis (J.C. Venter, ed.), Academic Press, 1994). Image processing included lane straightening, contrast adjustment to smooth out intensity differences, and resolution enhancement by iterative gaussian deconvolution. The sequences were then automatically picked in REPLICA™ and displayed for interactive proofreading before being stored in a project database. The proofreading was accomplished by a quick visual scan of the film image followed by mouse clicks on the bands of the displayed image to modify the base calls. For typical sequences derived by chemical sequencing, the error rate of the REPLICA™ base calling software was 2-5% with most errors occurring near the end of a sequence read. Many of the sequence errors could be detected and corrected because multiple sequence reads covering the same portion of the genomic DNA provide adequate sequence redundancy for editing. Each sequence automatically received a number correspond to (microtiter plate and probe information) and lane set number (corresponding to microtiter plate columns). This number serves as a permanent identifier of the sequence so it is always possible to identify the original of any particular sequence without recourse to a specialized database.

Routine assembly of H. pylori sequences was done using the program FALCON (Church, Church et al., Automated DNA Sequenicng and Analysis (J.C. Venter, ed.), Academic Press, 1994). This program has proven to be fast and reliable for most sequences. The assembled contigs were displayed using a modified version of GelAssemble, developed by the Genetics Computer Group (GCG) (Devereux et al., Nucleic Acid Res. 12:387-95, 1984) that interacts with REPLICA™. This provided for an integrated editor that allows multiple sequence gel images to be instantaneously called up from the REPLICA™ database and displayed to allow rapid scanning of contigs and proofreading of gel traces where discrepancies occurred between different sequence reads in the assembly.

II. Identification. Cloning and Expression of H. pylori Nucleic Acids

Expression and purification of the H. pylori polypeptides of the invention can be performed essentially as outlined below. To facilitate the cloning, expression and purification of membrane and secreted proteins from H. pylori, a gene expression system, such as the pET System (Novagen), for cloning and expression of recombinant proteins in E. coli, is selected. Also, a DNA sequence encoding a peptide tag, the Ηis-Tag, is fused to the 3' end of DNA sequences of interest in order to facilitate purification of the recombinant protein products. The 3' end is selected for fusion in order to avoid alteration of any 5' terminal signal sequence. The exception to the above is ppiB, a gene cloned for use as a control in the expression studies. The sequence for H. pylori ppiB contains a DNA sequence encoding a Ηis-Tag fused to the 5' end of the full length gene, because the protein product of this gene does not contain a signal sequence and is expressed as a cytosolic protein. PCR Amplification and Cloning of Nucleic Acids Containing ORF's for Membrane and Secreted Polypeptides from H. pylori Nucleic acids chosen (for example, from the nucleic acids set forth in the Sequence Listing) for cloning from the J99 strain of H. pylori are prepared for amplification cloning by polymerase chain reaction (PCR). Synthetic oligonucleotide primers specific for the 5' and 3' ends of open reading frames (ORFs) are designed and purchased from GibcoBRL Life Technologies (Gaithersburg, MD, USA). All forward primers (specific for the 5' end of the sequence) are designed to include an Ncol cloning site at the extreme 5' terminus. These primers are designed to permit initiation of protein translation at a methionine residue followed by a valine residue and the coding sequence for the remainder of the native H. pylori DNA sequence. All reverse primers (specific for the 3' end of any H. pylori ORF) include a EcoRI site at the extreme 5' terminus to permit cloning of each H. pylori sequence into the reading frame of the pET- 28b. The pET-28b vector provides sequence encoding an additional 20 carboxy- terminal amino acids including six histidine residues (at the extreme C-terminus), which comprise the Ηis-Tag. An exception to the above, as noted earlier, is the vector construction for the ppiB gene. A synthetic oligonucleotide primer specific for the 5' end of ppiB gene encodes a BamΗI site at its extreme 5' terminus and the primer for the 3' end of the ppiB gene encodes a Xhol site at its extreme 5' terminus. Genomic DNA prepared from the J99 strain of H. pylori is used as the source of template DNA for PCR amplification reactions (Current Protocols in Molecular Biology, John Wiley and Sons, Inc., F. Ausubel et al., eds., 1994). To amplify a DNA sequence containing an H. pylori ORF, genomic DNA (50 nanograms) is introduced into a reaction vial containing 2 mM MgCl2, 1 micromolar synthetic oligonucleotide primers (forward and reverse primers) complementary to and flanking a defined H. pylori ORF, 0.2 mM of each deoxynucleotide triphosphate; dATP, dGTP, dCTP, dTTP and 2.5 units of heat stable DNA polymerase (Amplitaq, Roche Molecular Systems, Inc., Branchburg, NJ, USA) in a final volume of 100 microliters.

Upon completion of thermal cycling reactions, each sample of amplified DNA is washed and purified using the Qiaquick Spin PCR purification kit (Qiagen,

Gaithersburg, MD, USA). All amplified DNA samples are subjected to digestion with the restriction endonucleases, e.g., Ncol and EcoRI (New England BioLabs, Beverly, MA, USA)(Current Protocols in Molecular Biology, John Wiley and Sons, Inc., F. Ausubel et al., eds., 1994). DNA samples are then subjected to electrophoresis on 1.0 % NuSeive (FMC BioProducts, Rockland, ME USA) agarose gels. DNA is visualized by exposure to ethidium bromide and long wave uv irradiation. DNA contained in slices isolated from the agarose gel is purified using the Bio 101 GeneClean Kit protocol (Bio 101 Vista, CA, USA)

Cloning ofH pylori Nucleic Acids Into an Expression Vector The pET-28b vector is prepared for cloning by digestion with endonucleases, e.g., Ncol and EcoRI (Current Protocols in Molecular Biology, John Wiley and Sons, Inc., F. Ausubel et al., eds., 1994). In the case of cloning ppiB, the pET-28a vector, which encodes a His-Tag that can be fused to the 5' end of an inserted gene, is used and the cloning site prepared for cloning with the ppiB gene by digestion with BamHI and Xhol restriction endonucleases. Following digestion, DNA inserts are cloned (Current Protocols in Molecular

Biology, John Wiley and Sons, Inc., F. Ausubel et al., eds., 1994) into the previously digested pET-28b expression vector, except for the amplified insert for ppiB, which is cloned into the pET-28a expression vector. Products of the ligation reaction are then used to transform the BL21 strain of E. coli (Current Protocols in Molecular Biology, John Wiley and Sons, Inc., F. Ausubel et al., eds., 1994) as described below. Transformation Of Competent Bacteria With Recombinant Plasmids Competent bacteria, E coli strain BL21 or E. coli strain BL21(DE3), are transformed with recombinant pET expression plasmids carrying the cloned H. pylori sequences according to standard methods (Current Protocols in Molecular, John Wiley and Sons, Inc., F. Ausubel et al., eds., 1994). Briefly, 1 microliter of ligation reaction is mixed with 50 microliters of electrocompetent cells and subjected to a high voltage pulse, after which, samples are incubated in 0.45 milliliters SOC medium (0.5% yeast extract, 2.0 % tryptone, 10 mM NaCl, 2.5 mM KC1, 10 mM MgC12, 10 mM MgSO4 and 20, mM glucose) at 37°C with shaking for 1 hour. Samples are then spread on LB agar plates containing 25 microgram ml kanamycin sulfate for growth overnight.

Transformed colonies of BL21 are then picked and analyzed to evaluate cloned inserts as described below.

Identification Of Recombinant Expression Vectors With H. Pylori Nucleic Acids Individual BL21 clones transformed with recombinant pET-28b-H.pylori ORFs are analyzed by PCR amplification of the cloned inserts using the same forward and reverse primers, specific for each H. pylori sequence, that were used in the original PCR amplification cloning reactions. Successful amplification verifies the integration of the H pylori sequences in the expression vector (Current Protocols in Molecular Biology, John Wiley and Sons, Inc., F. Ausubel et al., eds., 1994). Isolation and Preparation of Nucleic Acids From Transformants Individual clones of recombinant pET-28b vectors carrying properly cloned H. pylori ORFs are picked and incubated in 5 mis of LB broth plus 25 microgram/ml kanamycin sulfate overnight. The following day plasmid DNA is isolated and purified using the Qiagen plasmid purification protocol (Qiagen Inc., Chatsworth, CA, USA). Expression Of Recombinant H. Pylori Sequences In E. coli The pET vector can be propagated in any E. coli K-12 strain e.g. ΗMS174, HB101, JM109, DH5, etc. for the purpose of cloning or plasmid preparation. Hosts for expression include E. coli strains containing a chromosomal copy of the gene for T7 RNA polymerase. These hosts are lysogens of bacteriophage DE3, a lambda derivative that carries the la gene, the lacUV5 promoter and the gene for T7 RNA polymerase. T7 RNA polymerase is induced by addition of isopropyl-B-D-thiogalactoside (IPTG), and the T7 RNA polymerase transcribes any target plasmid, such as pET-28b, carrying its gene of interest. Strains used include: BL21(DE3) (Studier, F.W., Rosenberg, A.H., Dunn, J.J., and Dubendorff, J.W. (1990) Meth. Enzymol. 185, 60-89).

To express recombinant H. pylori sequences, 50 nanograms of plasmid DNA isolated as described above is used to transform competent BL21(DE3) bacteria as described above (provided by Novagen as part of the pET expression system kit). The lacZ gene (beta-galactosidase) is expressed in the pET-System as described for the H. pylori recombinant constructions. Transformed cells are cultured in SOC medium for 1 hour, and the culture is then plated on LB plates containing 25 micrograms/ml kanamycin sulfate. The following day, bacterial colonies are pooled and grown in LB medium containing kanamycin sulfate (25 micrograms/ml) to an optical density at 600 nM of 0.5 to 1.0 O.D. units, at which point, 1 millimolar IPTG was added to the culture for 3 hours to induce gene expression of the H. pylori recombinant DNA constructions . After induction of gene expression with IPTG, bacteria are pelleted by centrifugation in a Sorvall RC-3B centrifuge at 3500 x g for 15 minutes at 4°C. Pellets are resuspended in 50 milliliters of cold 10 mM Tris-HCl, pH 8.0, 0.1 M NaCl and 0.1 mM EDTA (STE buffer). Cells are then centrifuged at 2000 x g for 20 min at 4°C. Wet pellets are weighed and frozen at -80°C until ready for protein purification.

III. Purification Of Recombinant Proteins From E. Coli Analytical Methods

The concentrations of purified protein preparations are quantified spectrophotometrically using absorbance coefficients calculated from amino acid content (Perkins, S.J. 1986 Eur. J. Biochem. 157, 169-180). Protein concentrations are also measured by the method of Bradford, M.M. (1976) Anal. Biochem. 72, 248-254, and Lowry, O.H., Rosebrough, N., Farr, A.L. & Randall, R.J. (1951) J. Biol. Chem. 193, pages 265-275, using bovine serum albumin as a standard.

SDS-polyacrylamide gels (12% or 4.0 to 25 % acrylamide gradient gels) are purchased from BioRad (Hercules, CA, USA), and stained with Coomassie blue.

Molecular weight markers include rabbit skeletal muscle myosin (200 kDa), E. coli (- galactosidase (116 kDa), rabbit muscle phosphorylase B (97.4 kDa), bovine serum albumin (66.2 kDa), ovalbumin (45 kDa), bovine carbonic anhydrase (31 kDa), soybean trypsin inhibitor (21.5 kDa), egg white lysozyme (14.4 kDa) and bovine aprotinin (6.5 kDa).

1. Purification of soluble proteins

All steps are carried out at 4°C. Frozen cells are thawed, resuspended in 5 volumes of lysis buffer (20 mM Tris, pH 7.9, 0.5 M NaCl, 5 mM imidazole with 10% glycerol, 0.1 % -mercaptoethanol, 200 (g/ ml lysozyme, 1 mM phenylmethylsulfonyl fluoride (PMSF), and 10 ug/ml each of leupeptin, aprotinin, pepstatin, L-l-chloro-3-[4- tosylamido]-7-amino-2-heptanone (TLCK), L-l-chloro-3-[4-tosylamido]-4-phenyl-2- butanone (TPCK), and soybean trypsin inhibitor, and ruptured by several passages through a small volume microfluidizer (Model M-l 10S, Microfluidics International Corporation, Newton, MA). The resultant homogenate is made 0.1 % Brij 35, and centrifuged at 100,000 x g for 1 hour to yield a clear supernatant (crude extract).

Following filtration through a 0.8 (m Supor filter (Gelman Sciences, FRG) the crude extract is loaded directly onto a Ni^^+" nitrolotriacetate-agarose (NTA) with a 5 milliliter bed volume (Hochuli, E., Dbeli, H., and Schacheer, A. (1987) J. Chromatography 411, 177-184) pre-equilibrated in lysis buffer containing 10 % glycerol, 0.1 % Brij 35 and 1 mM PMSF. The column is washed with 250 ml (50 bed volumes) of lysis buffer containing 10 % glycerol, 0.1 % Brij 35, and are eluted with sequential steps of lysis buffer containing 10 % glycerol, 0.05 % Brij 35, 1 mM PMSF, and: either 20, 100, 200, or 500 mM imidazole. Fractions are monitored by absorbance at OD2go nm, and peak fractions are analyzed by SDS-PAGE. 2. Purification of insoluble proteins from inclusion bodies

The following steps are carried out at 4°C. Cell pellets are resuspended in lysis buffer with 10% glycerol 200 (g/ ml lysozyme, 5 mM EDTA, ImM PMSF and 0.1 % - mercaptoethanol. After passage through the cell disrupter, the resulting homogenate is made 0.2 % deoxycholate, stirred 10 minutes, then centrifuged at 20.000 x g, for 30 min. The pellets are washed with lysis buffer containing 10 % glycerol, 10 mM EDTA, 1% Triton X-100, 1 mM PMSF and 0.1% -mercaptoethanol, followed by several washes with lysis buffer containing 1 M urea, 1 mM PMSF and 0.1 % -mercaptoethanol. The resulting white pellet is composed primarily of inclusion bodies, free of unbroken cells and membranous materials.

Dialysis and concentration of protein samples Urea is removed slowly from the protein samples by dialysis against Tris- buffered saline (TBS; 10 mM Tris pH 8.0, 150 mM NaCl) containing 0.5 % deoxycholate (DOC) with sequential reduction in urea as follows; 6M, 4M, 3M, 2M, 1M, 0.5 M and finally TBS without any urea. Each dialysis step is conducted for a minimum of 4 hours at room temperature. After dialysis, samples are concentrated by pressure filtration using Amicon stirred-cells. Protein concentrations are measured using the methods of Perkins (1986 Eur. J. Biochem. 157, 169-180), Bradford ((1976) Anal. Biochem. 72, 248-254) and Lowry ((1951) J. Biol. Chem. 193, pages 265-275).

IV. Assessment Of The Antigenicity Of Outer Membrane Localized Antigens Of H. pylori

Purification of outer membranes form H. pylori can be performed by essentially follwing the protocol outlined below.

H. pylori strains J99 (ATCC# 55679) and Ah244 are grown on chocolate blood agar containing 5% (vol/vol) horse blood, at 37(C in an atmosphere containing 10%

CO2 for 48 h. Bacteria were harvested by suspension in 20 mM Tris, pΗ 7.5. The cells are collected by centrifugation at 12,000 Xg, for 20 min at 4(C and washed 3 times with 20 mM Tris, pΗ 7.5. Cells are suspended in 20 mM Tris, pΗ 7.5 and broken by sonication on ice (eight bursts of 30 s at 60 watts with 60 s pauses between bursts). DNase (0.1 mg) and RNase (0.5 mg) are added to the cell suspension, and the mixture is incubated for 30 minutes at room temperature. The cell suspension is centrifuged at 12,000 Xg for 20 min, at 4(C. The supernatant was retained and centrifuged again. Total membranes are collected from the supernatant by centrifugation at 40,000 Xg for 30 minute, at 4°C. The pellet are washed twice in 20 mM Tris, pΗ 7.5. The protein content is assayed using the Bradford protein assay, with bovine serum albumin (BSA) as a standard. The suspension is then adjusted to 1 mg protein /ml. The solubilization of the membranes is realized by adding N-lauryl-sarcosine to this suspension in a ratio of 6 mg of N-lauryl-sarcosine per mg of protein. The suspension is incubated for 30 minutes at room temperature in presence of N-lauryl-sarcosine. Outer membranes are collected by centrifugation at 40,000 Xg for 30 minutes at 4°C. The pellet is washed 3 times with Milli Q quality water, aliquoted and stored at -20°C until use. Identification Of Outer Membrane Antigens ofH. pylori Outer membrane antigens can be identified using a protocol outlined below. Proteins are separated on sodium dodecylsulfate polyacrylamide gels (SDS- PAGE) according to the method described by Laemmli, U.K. (1970) Nature (London) Volume 227, 680-685. Samples are prepared by suspension in standard treatment buffer and heated at 100°C for 10 min. Approximately 1-5 mg of protein is loaded per well on 8X10 cm minigels (0.75 mm). The separated proteins are then transferred to PVDF membranes as described below.

Electroblotting of separated proteins to PVDF membranes is performed in a Bio Rad Mini -Trans Blot Electrophoretic Transfer cell. The PVDF membrane Immobilon- pSQ is employed. Electroblotting is carried out for 60 min at 50V using CAPS transfer buffer (lOmM 3-[Cyclohexylamino]-l-propanesulfonic acid, 10% methanol). The membrane is stained with 0.2% Ponceau S and destained with Milli Q quality water. Antigens within the preparation are then identified using western immunoblotting. After electroblotting, non specific binding sites of the PVDF membrane are blocked with 5% non fat dry milk in 10 mM Tris-HCl-0.9% NaCl, pH 7.5. The membrane is incubated with a appropriate dilution of normal mouse serum in 10 mM Tris-HCl-0.9% NaCl-0.5% Tween 20-0.5% BSA, pH 7.5, for 2 h at 37(C and then washed three times with 10 mM Tris-HCl-0.9% NaCl-0.5% Tween 20, pH 7.5 (TTBS). Alkaline phosphatase conjugated anti-mouse Ig, from goat is then added in 10 mM Tris-HCl-0.9% NaCl-0.5% Tween 20-0.5% BSA, pH 7.5 and incubated for lh at room temperature. After this incubation, the membrane is washed three times in TTBS. The reactive bands are revealed using 5-bromo-4-chloro-3-indolyl phosphate (Bio-Rad) as the Alkaline phosphatase substrate and Nitro Blue Tetrazolium (Bio-Rad) as the color development reagent.

For amino acid microsequencing, proteins that are identified as immunoreactive are cut from a fresh unreacted immobilon membranes and microsequenced at the Worcester Foundation microsequencing facility. Membranes from which the protein bands are cut are then subjected to western immunoblot as described above to confirm that the appropriate band had been excised.

V. Analysis OfH. Pylori Proteins As Vaccine Candidates

To investigate the immunomodulatory effect ofH. pylori proteins, a mouse/H. pylori model was used. This model mimics the human H. pylori infection in many respects. The focus is on the effect of oral immunization in H. pylori infected animals in order to test the concept of therapeutic oral immuno therapy. Animals

Female SPF BALB/c mice were purchased from Bomholt Breeding center (Denmark). They were kept in ordinary makrolon cages with free supply of water and food. The animals were 4-6 weeks old at arrival. Infection

After a minimum of one week of acclimatization, the animals were infected with a type 2 strain (VacA negative) ofH. pylori (strain 244, originally isolated from an ulcer patient). In our hands, this strain has earlier proven to be a good colonizer of the mouse stomach. The bacteria were grown overnight in Brucella broth supplemented with 10 % fetal calf serum, at 37°C in a microaerophilic atmosphere (10% CO₂, 5%O₂). The animals were given an oral dose of omeprazole (400 μmol/kg) and 3-5 h after this an oral inoculation ofH. pylori in broth (approximately 10 cfu/animal). Positive take of the infection was checked in some animals 2-3 weeks after the inoculation.

Antigens Recombinant H. pylori antigens were chosen based on their association with externally exposed H. pylori cell membrane. These antigens were selected from the following groups: (1.) Outer Membrane Proteins; (2.) Periplastic/Secreted proteins; (3.) Outer Surface proteins; and (4.) Inner Membrane proteins. All recombinant proteins were constructed with a hexa-ΗIS tag for purification reasons and the non-Helicobacter pylori control protein (β-galactosidase from E. coli; LacZ), was constructed in the same way.

All antigens were given in a soluble form, i.e. dissolved in either a ΗEPES buffer or in a buffer containing 0.5% Deoxycholate (DOC).

The antigens are listed in Table 8 below.

Table 8

Helicobacter pylori proteins

Outer membrane Proteins Protein 1 Protein 2 Protein 3 Protein 4 Protein 5

Periplastic/Secreted proteins

Protein 6

Other cell envelope proteins Protein 7 Protein 8 Flagella-associated proteins

Protein 9

Control proteins β-galactosidase (LacZ)

Immunizations

Ten animals in each group were immunized 4 times over a 34 day period (day 1 , 15, 25 and 35). Purified antigens in solution or suspension were given at a dose of 100 μg/mouse. As an adjuvant, the animals were also given 10 μg/mouse of Cholera toxin (CT) with each immunization. Omeprazole (400 μmol/kg) was given orally to the animals 3-5 h prior to immunization as a way of protecting the antigens from acid degradation. Infected control animals received HEPES buffer + CT or DOC buffer + CT. Animals were sacrificed 2-4 weeks after final immunization. A general outline of the study is shown in Table 9 below.

Table 9

Study outline, therapeutic immunization:

Mice were all infected with H. pylori strain Ah244 at day 30.

Mouse strain Dates for

Substance n≡lO Dose/mouse dosing 1. Controls, PBS Balb/c 0.3 ml 0, 14, 24, 34

2. Cholera toxin, 10 μg Balb/c 0.3 ml 0, 14, 24, 34

3. Protein 1, 100 μg + CT 10 μg Balb/c 0.3 ml 0, 14, 24, 34

4. Protein 5, 100 μg + CT 10 μg Balb/c 0.3 ml 0, 14, 24, 34

5. Protein 10, 100 μg + CT 10 μg Balb/c 0.3 ml 0, 14, 24, 34 6. Protein 9, 100 μg + CT 10 μg Balb/c 0.3 ml 0, 14, 24, 34

7. Protein 2, 100 μg + CT 10 μg Balb/c 0.3 ml 0, 14, 24, 34

8. Protein 6, 100 μg + CT 10 μg Balb/c 0.3 ml 0, 14, 24, 34

9. Protein 4, 100 μg + CT 10 μg Balb/c 0.3 ml 0, 14, 24, 34 10. Protein 7, 100 μg + CT 10 μg Balb/c 0.3 ml 0, 14, 24, 34 11. Protein 8, 100 μg + CT 10 μg Balb/c 0.3 ml 0, 14, 24, 34 12. Protein 3, 100 μg + CT 10 μg Balb/c 0.3 ml 0, 14, 24, 34

Analysis of infection

Mucosal infection: The mice were sacrificed by C0 and cervical dislocation. The abdomen was opened and the stomach removed. After cutting the stomach along the greater curvature, it was rinsed in saline. The mucosa from the antrum and corpus of an area of 25mm was scraped separately with a surgical scalpel. The mucosa scraping was suspended in Brucella broth and plated onto Blood Skirrow selective plates. The plates were incubated under microaerophilic conditions for 3-5 days and the number of colonies was counted. The identity ofH. pylori was ascertained by urease and catalase test and by direct microscopy or Gram staining.

The urease test was performed essentially as follows. The reagent, Urea Agar Base Concentrate, was purchased from DIFCO Laboratories, Detroit, MI (Catalog # 0284-61-3). Urea agar base concentrate was diluted 1 :10 with water. 1 ml of if the diluted concentrate was mixed with 100-200 μl of actively growing H. pylori cells. Color change to magenta indicated that cells were urease positive.

The catalase test was performed essentially as follows. The reagent, N,N,N',N'- Tetramethyl-p-Phenylenediamine, was purchased from Sigma, St. Louis, MO (Catalog # T3134). A solution of the regent (1% w/v in water) was prepared. H. pylori cells were swabbed onto Whatman filter paper and overlaid with the 1 % solution. Color change to dark blue indicated that the cells were catalase positive.

Serum antibodies: From all mice serum was prepared from blood drawn by heart puncture. Serum antibodies were identified by regular ELISA techniques, where the specific antigens of Helicobacter pylori were plated.

Mucosal antibodies: Gentle scrapings of a defined part of the corpus and of 4 cm of duodenum were performed in 50% of the mice in order to detect the presence of antibodies in the mucous. The antibody titers were determined by regular ELISA technique as for serum antibodies.

Statistical analysis: Wilcoxon-Mann- Whitney sign rank test was used for determination of significant effects of the antigens on Helicobacter pylori colonization. PO.05 was considered significant. Because the antrum is the major colonization site for Helicobacter most emphasis was put upon changes in the antral colonization.

Results

Antibodies in sera: All antigens tested given together with CT gave rise to a measurable specific titer in serum. The highest responses were seen with Proteins 3, 4,

9, 1, and 7 (see Figure 1). Antibodies in mucus: In the mucus scrapings, specific antibodies against all antigens tested were seen. By far the strongest response was seen with Protein 6, followed by 1, 3, and 9 (see Figure 2).

Therapeutic immunization effects:

All control animals (B ALB/c mice) were well colonized with H. pylori (strain AΗ244) in both antrum and corpus of the stomach. Of the antigens tested 3 proteins (Proteins 4, 7, and 1) gave a good and significant reduction and/or eradication of the H pylori infection. The degree of colonization of the antrum was lower following immunization with Proteins 8, 9, and 3 compared to control. The effect of Proteins 5, 2, and 6 did not differ from control. The control protein lacZ, i.e. the non-H. pylori protein, had no eradication effect and in fact had higher Helicobacter colonization compared to the ΗEPES + CT control. All data are shown in Figures 3 and 4 for proteins dissolved in ΗEPES and DOC respectively. Data is shown as geometric mean values. n=8-10 Wilcoxon-Mann- Whitney sign rank test * = p<0.05; x/10 = number of mice showing eradication ofH. pylori over the total number of mice examined.

The data presented indicate that all of the H. pylori associated proteins included in this study, when used as oral immunogens in conjunction with the oral adjuvant CT, resulted in stimulation of an immune response as measured by specific serum and mucosal antibodies. A majority of the proteins led to a reduction, and in some cases complete clearance of the colonization ofH. pylori in this animal model. It should be noted that the reduction or clearance was due to heterologous protection rather than homologous protection (the polypeptides were based on the H. pylori J99 strain sequence and used in the therapeutic immunization studies against a different (AΗ244) challenge strain), indicating the vaccine potential against a wide variety ofH. pylori strains.

The highest colonization in the antrum was seen in animals treated with the non- Helicobacter protein LacZ, indicating that the effects seen with the Helicobacter pylori antigens were specific.

Taken together these data strongly support the use of these H. pylori proteins in a pharmaceutical formulation for the use in humans to treat and/or prevent H. pylori infections.

VI. Sequence Variance Analysis of genes in Helicobacter pylori strains

Four genes were cloned and sequenced from several strains ofH. pylori to compare the DNA and deduced amino acid sequences. This information was used to determine the sequence variation between the H. pylori strain, J99, and other H. pylori strains isolated from human patients.

Preparation of Chromosomal DNA.

Cultures ofH. pylori strains (as listed in Table 12) were grown in BLBB (1% Tryptone, 1% Peptamin 0.1% Glucose, 0.2% Yeast Extract 0.5% Sodium Chloride, 5% Fetal Bovine Serum) to an OD₆₀o of 0.2. Cells were centrifuged in a Sorvall RC-3B at 3500 x g at 4°C for 15 minutes and the pellet resuspended in 0.95 mis of 10 mM Tris- ΗC1, 0.1 mM EDTA (TE). Lysozyme was added to a final concentration of lmg/ml along with, SDS to 1% and RNAse A + Tl to 0.5mg/ml and 5 units/ml respectively, and incubated at 37°C for one hour. Proteinase K was then added to a final concentration of 0.4mg/ml and the sample was incubated at 55 C for more than one hour. NaCl was added to the sample to a concentration of 0.65 M, mixed carefully, and 0.15 ml of 10% CTAB in 0.7M NaCL (final is 1% CTAB/70mM NaCL) was added followed by incubation at 65°C for 20 minutes. At this point, the samples were extracted with chloroform:isoamyl alcohol, extracted with phenol, and extracted again with chloroform:isoamyl alcohol. DNA was precipitated with either EtOH (1.5 x volumes) or isopropanol (0.6 x volumes) at -70°C for lOminutes, washed in 70% EtOH and resuspended in TE.

PCR Amplification and cloning.

Genomic DNA prepared from twelve strains of Helicobacter pylori was used as the source of template DNA for PCR amplification reactions (Current Protocols in Molecular Biology, John Wiley and Sons, Inc., F. Ausubel et al., editors, 1994). To amplify a DNA sequence containing an H. pylori ORF, genomic DNA (10 nanograms) was introduced into a reaction vial containing 2 mM MgCl₂, 1 micromolar synthetic oligonucleotide primers (forward and reverse primers, see Table 10) complementary to and flanking a defined H. pylori ORF, 0.2 mM of each deoxynucleotide triphosphate; dATP, dGTP, dCTP, dTTP and 0.5 units of heat stable DNA polymerase (Amplitaq, Roche Molecular Systems, Inc., Branchburg, NJ, USA) in a final volume of 20 microliters in duplicate reactions.

Table 10 Oligonucleotide primers used for PCR amplification ofH. pylori DNA sequences.

The following thermal cycling conditions were used to obtain amplified DNA products for each ORF using a Perkin Elmer Cetus/ GeneAmp PCR System 9600 thermal cycler:

Sequences for Proeins 12 and 14;

Denaturation at 94°C for 2 min,

2 cycles at 94°C for 15 sec, 30°C for 15 sec and 72°C for 1.5 min

23 cycles at 94°C for 15 sec, 55°C for 15 sec and 72°C for 1.5 min

Reactions were concluded at 72°C for 6 minutes.

Sequence for Protein 11 for strains AH5, 5155, 7958, AH24,and J99; Denaturation at 94°C for 2 min,

2 cycles at 94°C for 15 sec, 30°C for 15 sec and 72°C for 1.5 min 25 cycles at 94°C for 15 sec, 55°C for 15 sec and 72°C for 1.5 min Reaction was concluded at 72°C for 6 minutes.

Sequences for Protein 11 and Protein 13 for strains AH4, AH15, AH61, 5294, 5640, AH18, and Hp244_Q; Denaturation at 94°C for 2 min, 2 cycles at 94°C for 15 sec, 30°C for 20 sec and 72°C for 2 min 25 cycles at 94°C for 15 sec, 55°C for 20 sec and 72°C for 2 min Reactions were concluded at 72°C for 8 minutes.

Upon completion of thermal cycling reactions, each pair of samples were combined and used directly for cloning into the pCR cloning vector as described below. Cloning ofH pylori DNA sequences into the pCR TA cloning vector.

All amplified inserts were cloned into the pCR 2.1 vector by the method described in the Original TA cloning kit (Invitrogen, San Diego, CA). Products of the ligation reaction were then used to transform the TOPI OF' (INVaF' in the case ofH. pylori sequence 350) strain of E. coli as described below.

Transformation of competent bacteria with recombinant plasmids Competent bacteria, E coli strain TOPI OF' or E. coli strain INVaF' were transformed with recombinant pCR expression plasmids carrying the cloned H. pylori sequences according to standard methods (Current Protocols in Molecular Biology, John Wiley and Sons, Inc., F. Ausubel et al., editors, 1994). Briefly, 2 microliters of 0.5 micromolar BME was added to each vial of 50 microliters of competent cells. Subsequently, 2 microliters of ligation reaction was mixed with the competent cells and incubated on ice for 30 minutes. The cells and ligation mixture were then subjected to a "heat shock" at 42°C for 30 seconds, and were subsequently placed on ice for an additional 2 minutes, after which, samples were incubated in 0.45 milliliters SOC medium (0.5% yeast extract, 2.0 % tryptone, 10 mM NaCl, 2.5 mM KC1, 10 mM MgC12, 10 mM MgS04 and 20, mM glucose) at 37°C with shaking for 1 hour. Samples were then spread on LB agar plates containing 25 microgram/ml kanamycin sulfate or 100 micrograms/ml ampicillan for growth overnight. Transformed colonies of TOPI OF' or INVaF' were then picked and analyzed to evaluate cloned inserts as described below. Identification of recombinant PCR plasmids carrying H. pylori sequences Individual TOPI OF' or INVaF' clones transformed with recombinant pCR- H.pylori ORFs were analyzed by PCR amplification of the cloned inserts using the same forward and reverse primers, specific for each H. pylori sequence, that were used in the original PCR amplification cloning reactions. Successful amplification verified the integration of the H. pylori sequences in the cloning vector (Current Protocols in Molecular Biology, John Wiley and Sons, Inc., F. Ausubel et al., editors, 1994).

Individual clones of recombinant pCR vectors carrying properly cloned H. pylori ORFs were picked for sequence analysis. Sequence analysis was performed on ABI Sequencers using standard protocols (Perkin Elmer) using vector-specific primers (as found in PCRII or pCR2.1, Invitrogen, San Diego, CA) and sequencing primers specific to the ORF as listed in Table 11 below.

Table 11

Oligonucleotide primers used for sequencing ofH. pylori DNA sequences.

Results

To establish the PCR error rate in these experiments, five individual clones of Protein 11 , prepared from five separate PCR reaction mixtures from H. pylori strain J99, were sequenced over a total length of 897 nucleotides for a cumulative total of 4485 bases of DNA sequence. DNA sequence for the five clones was compared to the DNA sequence of Protein 11 obtained previously by a different method, i.e., random shotgun cloning and sequencing. The PCR error rate for the experiments described herein was determined to be 2 base changes out of 4485 bases, which is equivalent to an estimated error rate of less than or equal to 0.04%.

DNA sequence analysis was performed on four different open reading frames identified as genes and amplified by PCR methods from a dozen different strains of the bacterium Helicobacter pylori. The deduced amino acid sequences of three of the four open reading frames that were selected for this study showed statistically significant BLAST homology to defined proteins present in other bacterial species. Those ORFs included: Protein 11, homologous to the val A & B genes encoding an ABC transporter in F. novicida; Protein 12, homologous to lipoprotein e (P4) present in the outer membrane of Η. influenzae; Protein 13, homologous to fee A, an outer membrane receptor in iron (III) dicitrate transport in E. coli. Protein 14 was identified as an unknown open reading frame, because it showed low homology with sequences in the public databases.

To assess the extent of conservation or variance in the ORFs across various strains ofH. pylori, changes in DNA sequence and the deduced protein sequence were compared to the DNA and deduced protein sequences found in the J99 strain ofH. pylori (see Table 12 below). Results are presented as percent identity to the J99 strain of H. pylori sequenced by random shotgun cloning. To control for any variations in the J99 sequence each of the four open reading frames were cloned and sequenced again from the J99 bacterial strain and that sequence information was compared to the sequence information that had been collected from inserts cloned by random shotgun sequencing of the J99 strain. The data demonstrate that there is variation in the DNA sequence ranging from as little as 0.12 % difference (Protein 14, J99 strain) to approximately 7% change (Protein 1 1, strain AH5). The deduced protein sequences show either no variation (Protein 14, strains AH 18 and AH24) or up to as much as 7.66% amino acid changes (Protein 11, Strain AH5).

TABLE 12

Multiple Strain DNA Sequence analysis ofH. pylori Vaccine Candidates J99 Protein #: 11 11 12 12 13 13 14 14

Length of Region 248 a a 746 nt 232 a a 696 nt 182 a a 548 nt 273 a a 819 nt

Sequenced

Strain Tested

AA Nuc AA Nuc AA Nuc AA Nuc identity identity identity identity identity identity identity identity

J99 100 00% 100 00% 100 00% 100 00% 100 00% 100 00% 99 63% 99 88%

AH244 95 16% 95 04% n d n d 99 09% 96 71% 98 90% 96 45%

AH4 95 97% 95 98% 97 84% 95 83% n d n d 97 80% 95 73%

AH5 92 34% 93 03% 98 28% 96 12% 98 91 % 96 90% 98 53% 95 73%

AH15 95 16% 94 91% 97 41 % 95 98% 99 82% 97 99% 99 63% 96 09%

AH61 n d n d 97 84% 95 98% 99 27% 97 44% n d n.d

5155 n d n d n d n d 99 45% 97 08% 98 53% 95 60%

5294 94 35% 94 37% 98 28% 95 40% 99 64% 97 26% 97 07% 9548%

7958 94 35% 94 10% 97 84% 95 40% n d n d 99 63% 96 46%

5640 95 16% 94 37% 97 41% 95 69% 99 09% 97 63% 98 53% 95 48%

AH18 n d n d 98 71% 95 69% 99 64% 97 44% 100 00% 95 97%

AH24 94 75% 95 04% 97 84% 95 40% 99 27% 96 71 % 100 00% 96 46% n d = not done

VII. Experimental Knock-Out Protocol for the Determination of Essential H pylori Genes as Potential Therapeutic Targets Therapeutic targets were chosen from genes whose protein products appear to play key roles in essential cell pathways such as cell envelope synthesis, DNA synthesis, transcription, translation, regulation and colonization/virulence.

The protocol for the deletion of portions ofH pylori genes/ORFs and the insertional mutagenesis of a kanamycin-resistance cassette was modified from previously published methods (Labigne-Roussel et al.. 1988, J. Bacteriology 170, pp.

1704-1708; Cover et al.,1994, J. Biological Chemistry 269, pp. 10566-10573; Reyrat et al., 1995, Proc. Natl. Acad. Sci. 92, pp 8768-8772).

Identification and Cloning ofH pylori Gene Sequences The sequences of the genes or ORFs (open reading frames) selected as knock-out targets were identified from the H pylori genomic sequence and used to design primers to specifically amplify the genes/ORFs. All synthetic oligonucleotide primers (Table 13) were designed with the aid of the OLIGO program (National Biosciences, Inc., Plymouth, MN 55447, USA), and were purchased from Gibco/BRL Life Technologies (Gaithersburg, MD, USA). Specific primers (Fl and Rl) were chosen which flanked most or all of the ORF, depending on its size. If the ORF was smaller than 800 to 1000 base pairs, flanking primers were chosen outside of the open reading frame.

TABLE 13 Oligonucleotide Sequences for K.nock-Out Gene/ORFs

O

TABLE 13 (continued)

h-¹ O OO

TABLE 13 (continued)

o

Genomic DNA prepared from the Helicobacter pylori HpJ99 strain (ATCC 55679) was used as the source of template DNA for amplification of the ORFs by PCR (polymerase chain reaction) (Current Protocols in Molecular Biology, John Wiley and Sons, Inc., F. Ausubel et al., editors, 1994). For the preparation of genomic DNA from H pylori, see Example I. PCR amplification was carried out by introducing 10 nanograms of genomic HpJ99 DNA into a reaction vial containing 10 mM Tris pH 8.3, 50 mM KC1, 2 mM MgCl₂, 2 microMolar synthetic oligonucleotide primers (forward=Fl and reverse=Rl), 0.2 mM of each deoxynucleotide triphosphate (dATP,dGTP, dCTP, dTTP), and 1.25 units of heat stable DNA polymerase (Amplitaq, Roche Molecular Systems, Inc., Branchburg, NJ, USA) in a final volume of 40 microliters. The PCR was carried out with Perkin Elmer Cetus/GeneAmp PCR System 9600 thermal cyclers. The thermal cycling conditions used to obtain amplified DNA products for each knock-out target are shown in Table 14. TABLE 14

PCR Conditions

MurC

Denaturation at 94°C for 2 min.,

25 cycles of 94°C for 15 sec, 48°C for 15 sec, 72°C for 1 min, 30 sec, Final Extension of 72°C for 20 minutes.

Sig54

Denaturation at 94°C for 2 min.,

25 cycles of 94°C for 15 sec, 50°C for 15 sec, 72°C for 1 min, 30 sec, Final Extension of 72°C for 20 minutes. lpxC

Denaturation at 94°C for 2 min.,

32 cycles of 94°C for 15 sec, 50°C for 15 sec, 72°C for 1 min, 30 sec, Final Extension of 72°C for 20 minutes.

KO24.KO26.KO27

Denaturation at 94 C for 2 min.,

25 cycles of 94°C for 15 sec, 50.5°C for 20 sec, 72°C for 2 min,

Final Extension of 72°C for 20 minutes.

KO29.26kDa Protein

Denaturation at 94 C for 2 min.,

28 cycles of 94°C for 15 sec, 50.5°C for 20 sec, 72°C for 2 min,

Final Extension of 72°C for 20 minutes.

DnaE.Glycyl

Denaturation at 94°C for 2 min.,

20 cycles of 94°C for 15 sec, 51°C for 15 sec, 72°C for 1 min, 30 sec,

Final Extension of 72°C for 20 minutes. Gltx

Denaturation at 94°C for 2 min.,

25 cycles of 94°C for 15 sec, 51°C for 15 sec, 72°C for 1 min, 30 sec,

Final Extension of 72°C for 20 minutes.

KO28

Denaturation at 94°C for 2 min.,

25 cycles of 94°C for 15 sec, 51°C for 15 sec, 72°C for 2min,

Final Extension of 72°C for 20 minutes.

KO30

Denaturation at 94°C for 2 min.,

25 cycles of 94°C for_Q15 sec, 51.5°C for 15 sec, 72°C for lmin, 45 sec,

Final Extension of 72°C for 20 minutes.

Murl. MurG

Denaturation at 94°C for 2 min.,

25 cycles of 94°C for 15 sec, 52°C for 15 sec, 72°C for 1 min, 30 sec,

Final Extension of 72°C for 20 minutes.

DnaB. KdtA.LpxB

Denaturation at 94 C for 2 min.,

27 cycles of 94°C for 15 sec, 52°C for 15 sec, 72°C for 1 min, 30 sec,

Final Extension of 72°C for 20 minutes.

Tsf.FlgE. FliM.Sig28.MurB

Denaturation at 94 C for 2 min.,

30 cycles of 94°C for 15 sec, 52°C for 15 sec, 72°C for 1 min, 30 sec,

Final Extension of 72° C for 20 minutes.

PpiB

Denaturation at 94°C for 2 min.,

30 cycles of 94°C for 15 sec, 52°C for 15 sec, 72°C for 2 min, 30 sec,

Final Extension of 72°C for 20 minutes.

MurD.MurE. AlgA.MetL.FusA.SerS.Rnh

Denaturation at 94 C for 2 min.,

30 cycles of 94°C for 15 sec, 55°C for 15 sec, 72°C for 1 min, 30 sec,

Final Extension of 72° C for 20 minutes.

Upon completion of thermal cycling reactions, each sample of amplified DNA was visualized on a 2% TAE agarose gel stained with Ethidium Bromide (Current Protocols in Molecular Biology, John Wiley and Sons, Inc., F. Ausubel et al.. editors, 1994) to determine that a single product of the expected size had resulted from the reaction. Amplified DNA was then washed and purified using the Qiaquick Spin PCR purification kit (Qiagen, Gaithersburg, MD, USA).

PCR products were cloned into the pT7Blue T-Vector (catalog#69820-l, Novagen, Inc., Madison, WI, USA) using the TA cloning strategy (Current Protocols in Molecular Biology, John Wiley and Sons, Inc., F. Ausubel et al., editors, 1994). The ligation of the PCR product into the vector was accomplished by mixing a 6 fold molar excess of the PCR product, 10 ng of pT7Blue-T vector (Novagen), 1 microliter of T4 DNA Ligase Buffer (New England Biolabs, Beverly, MA, USA), and 200 units of T4 DNA Ligase (New England Biolabs) into a final reaction volume of 10 microliters. Ligation was allowed to proceed for 16 hours at 16°C.

Ligation products were electroporated (Current Protocols in Molecular Biology, John Wiley and Sons, Inc., F. Ausubel et al., editors, 1994) into electroporation- competent XL-1 Blue or DH5-α E.coli cells (Clontech Lab., Inc. Palo Alto, CA, USA). Briefly, 1 microliter of ligation reaction was mixed with 40 microliters of electrocompetent cells and subjected to a high voltage pulse (25 microFarads, 2.5 kV, 200 ohms) after which the samples were incubated in 0.45 ml SOC medium (0.5% yeast extract, 2% tryptone, 10 mM NaCl, 2.5 mM KC1, 10 mM MgCl₂, 10 mM MgSO₄ and 20 mM glucose) at 37°C with shaking for 1 hour. Samples were then spread onto LB (10 g/1 bacto tryptone, 5 g/1 bacto yeast extract, 10 g/1 sodium chloride) plates containing 100 microgram/ml of Ampicillin, 0.3% X-gal, and 100 microgram/ml IPTG. These plates were incubated overnight at 37°C. Ampicillin-resistant colonies with white color were selected, grown in 5 ml of liquid LB containing 100 microgram ml of Ampicillin, and plasmid DNA was isolated using the Qiagen miniprep protocol (Qiagen, Gaithersburg, MD, USA). To verify that the correct Hpylori DNA inserts had been cloned, these pT7Blue plasmid DNAs were used as templates for PCR amplification of the cloned inserts, using the same forward and reverse primers (Fl and Rl) used for the initial amplification of the J99 Hpylori sequence. Recognition of the primers and a PCR product of the correct size as visualized on a 2% TAE, ethidium bromide stained agarose gel were confirmation that the correct inserts had been cloned. Two to six such verified clones were obtained for each knock-out target, and frozen at -70°C for storage. To minimize errors due to PCR, plasmid DNA from these verified clones were pooled, and used in subsequent cloning steps.

The sequences of the genes/ORFs were again used to design a second pair of primers (F2 and R2) which flanked the region ofH. pylori DNA to be either interrupted or deleted (up to 250 basepairs) within the ORFs but were oriented away from each other. The pool of circular plasmid DNAs of the previously isolated clones were used as templates for this round of PCR. Since the orientation of amplification of this pair of deletion primers was away from each other, the portion of the ORF between the primer would not be included in the resultant PCR product. The PCR product was a linear piece of DNA with H. pylori DNA at each end and the pT7Blue vector backbone - 11 J -

between them which, in essence, resulted in the deletion of a portion of the ORFs. The PCR product was visualized on a 1% TAE, ethidium bromide stained agarose gel to confirm that only a single product of the correct size had been amplified.

A Kanamycin-resistance cassette (Labigne-Roussel et al., 1988 J. Bacteriology 170, 1704- 1708) was ligated to this PCR product by the TA cloning method used previously (Current Protocols in Molecular Biology, John Wiley and Sons, Inc., F. Ausubel et al., editors, 1994). The Kanamycin cassette containing a Campylobacter kanamycin resistance gene was obtained by carrying out an EcoRI digestion of the recombinant plasmid pCTB8:kan (Cover et al.,1994, J. Biological Chemistry 269, pp. 10566-10573). The proper fragment (1.4 kb) was isolated on a 1% TAE gel, and isolated using the QIAquick gel extraction kit (Qiagen, Gaithersburg, MD, USA). The fragment was end repaired using the Klenow fill-in protocol, which involved mixing 4ug of the DNA fragment, 1 microliter of dATP,dGTP, dCTP, dTTP at 0.5 mM, 2 microliter of Klenow Buffer (New England Biolabs) and 5 units of Klenow DNA Polymerase I Large (Klenow) Fragment (New England Biolabs) into a 20 microliter reaction, incubating at 30°C for 15 min, and inactivating the enzyme by heating to 75°C for 10 minutes. This blunt-ended Kanamycin cassette was then purified through a Qiaquick column (Qiagen, Gaithersburg, MD, USA) to eliminate nucleotides. The OTO overhang was then generated by mixing 5 micrograms of the blunt-ended kanamycin cassette, 10 mM Tris pH 8.3, 50 mM KCl, 2 mM MgCl₂, 5 units of DNA Polymerase (Amplitaq, Roche Molecular Systems, Inc., Branchburg, NJ, USA), 20 microliters of 5 mM dTTP, in a 100 microliter reaction and incubating the reaction for 2 hours at 37°C. The "Kan- T" cassette was purified using a QIAquick column (Qiagen, Gaithersburg, MD, USA). The PCR product of the deletion primers (F2 and R2) was ligated to the Kan-T cassette by mixing 10 to 25 ng of deletion primer PCR product, 50 - 75 ng Kan-T cassette DNA, 1 microliter lOx T4 DNA Ligase reaction mixture, 0.5 microliter T4 DNA Ligase (New England Biolabs, Beverly, MA, USA) in a 10 microliter reaction reaction and incubating for 16 hours at 16°C.

The ligation products were transformed into XL-1 Blue or DH5-α E.coli cells by electroporation as described previously. After recovery in SOC, cells were plated onto LB plates containing 100 microgram/ml Ampicillin and grown overnight at 37°C. These plates were then replica plated onto plates containing 25 microgram/ml Kanamycin and allowed to grow overnight. Resultant colonies had both the Ampicillin resistance gene present in the pT7Blue vector, and the newly introduced Kanamycin resistance gene. Colonies were picked into LB containing 25 microgram ml Kanamycin and plasmid DNA was isolated using the Qiagen miniprep protocol (Qiagen, Gaithersburg, MD, USA).

Several tests by PCR amplification were conducted on these plasmids to verify that the Kanamycin was inserted in the H. pylori gene/ORF, and to determine the orientation of the insertion of the Kanamycin-resistance gene relative to the H. pylori gene/ORF. To verify that the Kanamycin cassette was inserted into the H. pylori sequence, the plasmid DNAs were used as templates for PCR amplification with the set of primers (Fl and Rl) originally used to clone the H. pylori gene/ORFs. The correct PCR product was the size of the deleted gene/ORF but increased in size by the addition of a 1.4 kilobase Kanamycin cassette. To avoid potential polar effects of the kanamycin resistance cassette on H. pylori gene expression, the orientation of the Kanamycin resistance gene with respect to the knock-out gene/ORF was determined and both orientations were eventually used in H. pylori transformations (see below). To determine the orientation of insertion of the kanamycin resistance gene, primers were designed from the ends of the kanamycin resistance gene ("Kan-1 " 5'-

ATCTTACCTATCACCTCAAAT-3' (SEQ ID NO:1285), and "Kan-2" 5'- AGACAGCAACATCTTTGTGAA-3' (SEQ ID NO: 1286)). By using each of the cloning primers (Fl and Rl) in conjunction with each of the Kan primers (4 combinations of primers), the orientation of the Kanamycin cassette relative to the Hpylori sequence was determined. Positive clones were classified as either in the "A" orientation (the same direction of transcription was present for both the H. pylori gene and the Kanamycin resistance gene), or in the "B" orientation (the direction of transcription for the Hpylori gene was opposite to that of the Kanamycin resistance gene). Clones which shared the same orientation (A or B) were pooled for subsequent experiments and independently transformed into H. pylori.

Transformation of Plasmid DNA into H pylori cells

Two strains ofH. pylori were used for transformation: ATCC 55679. the clinical isolate which provided the DNA from which H. pylori sequence database was obtained, and AΗ244, an isolate which had been passaged in, and had the ability to colonize the mouse stomach. Cells for transformation were grown at 37°C, 10% C0₂, 100% humidity, either on Sheep-Blood agar plates or in Brucella Broth liquid. Cells were grown to exponential phase, and examined microscopically to determine that the cells were "healthy" (actively moving cells) and not contaminated. If grown on plates, cells were harvested by scraping cells from the plate with a sterile loop, suspended in 1 ml of Brucella Broth, spun down (1 minute, top speed in eppendorf micro fuge) and resuspended in 200 microliters Brucella Broth. If grown in Brucella Broth liquid, cells were centrifuged (15 minutes at 3000 rpm in a Beckman TJ6 centrifuge) and the cell pellet resuspended in 200 microliters of Brucella broth. An aliquot of cells was taken to determine the optical density at 600 nm, in order to calculate the concentration of cells. An aliquot (1 to 5 OD₆₀₀ units/25 microliter) of the resuspended cells was placed onto a prewarmed Sheep-Blood agar plate, and the plate was further incubated at 37°C, 6% CO₂, 100% humidity for 4 hours. After this incubation, 10 microliters of plasmid DNA (100 micrograms per microliter), was spotted onto these cells. A positive control (plasmid DNA with the ribonuclease H gene disrupted by kanamycin resistance gene) and a negative control (no plasmid DNA) were done in parallel. The plates were returned to 37°C, 6% CO₂ for an additional 4 hours of incubation. Cells were then spread onto that plate using a swab wetted in Brucella broth, and grown for 20 hours at 37°C, 6% CO₂. Cells were then transferred to a Sheep-Blood agar plate containing 25 micrograms/ml Kanamycin, and allowed to grow for 3 to 5 days at 37°C, 6% CO₂, 100% humidity. If colonies appeared, they were picked and regrown as patches on a fresh Sheep-Blood agar plate containing 25 micrograms/ml Kanamycin.

Three sets of PCR (three tests) were done to verify that the colonies of transformants have arose from homologous recombination at the proper chromosomal location. The template for PCR (DNA from the colony) was obtained by a rapid boiling DNA preparation method. An aliquot of the colony (stab of the colony with a toothpick) was introduced into 100 microliters of 1% Triton X-100, 20 mM Tris, pH 8.5, and boiled for 6 minutes. An equal volume of phenol : chloroform (1 :1) was added and vortexed. The mixture was microfuged for 5 minutes and the supernatant was used as DNA template for PCR with combinations of the following primers to verify homologous recombination at the proper chromosomal location.

TEST 1 PCR with Fl and Rl primers (cloning primers originally used to amplify the gene/ORF). A positive result of homologous recombination at the correct chromosomal location should show a single PCR product whose size is expected to be the size of the deleted gene/ORF but increased in size by the addition of a 1.4 kilobase Kanamycin cassette. A PCR product of just the size of the gene/ORF was proof that the gene had not been knocked out and that the transformant was not the result of homologous recombination at the correct chromosome location.

TEST 2 PCR with F3 (primer designed from sequences upstream of the gene/ORF), and either primer Kan-1 or Kan-2 (primers designed from the ends of the kanamycin resistance gene), depending on whether the plasmid DNA used was of "A" or "B" orientation. A positive result of homologous recombination at the correct chromosomal location of the sequences of the gene/ORFs upstream from the kanamycin resistance gene should show a single PCR product, the expected size to be from the location of F3 to the insertion site of kanamycin resistance gene. No PCR product or PCR product(s) of incorrect size(s) would prove that the plasmid had not been integrated at the correct site and that the gene had not been knocked out.

TEST 3 PCR with R3 (primer designed from sequences downstream of the gene/ORF) and either primer Kan-1 or Kan-2, depending on whether the plasmid DNA used was of "A" or "B" orientation. A positive result of homologous recombination at the correct chromosomal location downstream from the kanamycin resistance gene would show a single PCR product, the expected size to be from the insertion site of kanamycin resistance gene to the downstream location of R3. Again, no PCR product or PCR product(s) of incorrect size(s) would prove that the plasmid had not been integrated at the correct site and that the gene had not been knocked out.

Genes that are not essential for survival in vitro normally resulted in many transformants as observed for the positive control of ribonuclease H gene. Any transformants showing positive results for all three tests above would result in the conclusion that the gene was not essential for survival in vitro.

Genes that are essential for survival in vitro normally showed very few transformants. All transformants would be screened. A negative result of any of the three above tests for each transformant would lead to the conclusion that the gene had not been disrupted, and that the gene was essential for survival in vitro.

In the event that no colonies resulted from two independent transformations while the positive control with the disrupted ribonuclease H plasmid DNA produced transformants, the plasmid DNA was further analyzed by PCR on DNA from transformant populations prior to plating for colony formation, to verify that it can enter the cells and undergo homologous recombination at the correct site. Briefly, plasmid DNA was incubated according to the transformation protocol described above. DNA was extracted from the H pylori cells immediately after incubation with the plasmid DNA and the DNA was used as templates for the above TEST 2 and TEST 3. Positive results of TEST 2 and TEST 3 would verify that the plasmid DNA could enter the cells and undergo homologous recombination at the correct chromosomal location. If TEST 2 and TEST 3 are positive, then failure to obtain viable transformants indicates that the gene is essential and cells suffering a disruption in that gene are incapable of colony formation Genes used in these experiments have been found to be essential, non-essential, or are still in progress, as indicated in Table 15. TABLE 15

VIII. Cloning, purification and characterization of the gene encoding the peptidyl- propyl cis-trans isomerase ofH. pylori

The Helicobacter pylori genome contains an open reading frame (ORF) of 170 amino acids was found to have homology with the Synechococcus sp. (strain PCC 7942).ppi gene (NCBI Accession number P29820). Therefore, to evaluate whether this

ORF encoded a protein with PPiase activity, the gene was isolated by polymerase chain reaction (PCR) amplification cloning, overexpressed in E. coli, and the protein purified to homogeneity. To facilitate purification, a polyhistidine tag was added to the N- terminus of this ORF. A simple assay using PPiase to evaluate protein folding function was developed for future use as a high-throughput drug screen.

Currently, the class of PPIases is divided into three unrelated families: the cyclophilins, the FK506-binding (FKBPs) and the parvulins. Although PPiase mutants have been reported from yeast and fruit fly, attempts to isolate disruption mutants in

Escherichia coli were unsuccessful (Shieh, B.Η., et.al. (1989) Nature 338:67-70). This suggests that this activity is essential for viability in bacteria.

Cloning, expression and protein purification

To facilitate the cloning, expression and purification of ppi from H. pylori, a powerful gene expression system, the pΕT System, for cloning and expression of recombinant ppi in Ε. coli. In this study, the sequence for H. pylori ppi contains a DNA sequence encoding a His-Tag fused to the 5' end of the full length gene, because the protein product of this gene does not contain a signal sequence and is expressed as a cytosolic protein.

A synthetic oligonucleotide primer (5'-TTATGGATCCAAACCAATTAAAA CT-3' (SΕQ ID NO:1287)) specific for the 5' end of ppi gene encoded a BamHI site at its extreme 5' terminus and a primer (5'-TATCTCGAGTTATAGAGAAGGGC-3' (SΕQ ID NO: 1288)) specific for the 3' end of the ppi gene encoded a Xhol site at its extreme 5' terminus. Genomic DNA prepared from the J99 strain of Helicobacter pylori was used as the source of template DNA for PCR amplification reactions (Current Protocols in Molecular Biology, John Wiley and Sons, Inc., F. Ausubel et al., editors, 1994). To amplify a DNA sequence containing the H. pylori ppi gene, genomic DNA (50 nanograms) was introduced into a reaction vial containing 2 mM MgCl₂, 1 micromolar synthetic oligonucleotide primers (forward and reverse primers) complementary to and flanking a defined H. pylori ORF, 0.2 mM of each deoxynucleotide triphosphate; dATP, dGTP, dCTP, dTTP and 2.5 units of heat stable DNA polymerase (Amplitaq, Roche Molecular Systems, Inc., Branchburg, NJ, USA) in a final volume of 100 microliters. The following thermal cycling conditions were used to obtain amplified DNA products for each ORF using a Perkin Elmer Cetus/ GeneAmp PCR System 9600 thermal cycler:

Conditions for amplification ofH. pylori ppiB;

Denaturation at 94°C for 2 min,

2 cycles at 94°C for 15 sec, 32°C for 15 sec and 72°C for 1.5 min 25 cycles at 94°C for 15 sec, 56°C for 15 sec and 72°C for 1.5 min Reactions were concluded at 72°C for 6 minutes.

Upon completion of thermal cycling reactions, the amplified DNA was washed and purified using the Qiaquick Spin PCR purification kit (Qiagen, Gaithersburg, MD, USA). The amplified DNA sample was subjected to digestion with the restriction endonucleases, BamHI and Xhol (New England BioLabs, Beverly, MA, USA) (Current Protocols in Molecular Biology, Ibid). The DNA as subjected to electrophoresis on a 1.0 % NuSeive (FMC BioProducts, Rockland, ME USA) agarose gel. DNA was visualized by exposure to ethidium bromide and long wave uv irradiation. DNA contained in slices isolated from the agarose gel was purified using the Bio 101 GeneClean Kit protocol (Bio 101 Vista, CA, USA) Cloning, transformation, expression and purification of the PPI gene was carried out essentially as described in Examples II and III above.

Assay for PPiase activity

The assay for PPiase was essentially as described by Fisher (Fischer, G., et.al. ( 1984) Biomed. Biochim. Acta 43 : 1101 - 1111 ). The assay measures the cis-trans isomerization of the Ala-Pro bond in the test peptide N-succinyl-Ala-Ala-Pro-Phe-p- nitroanilide (Sigma # S-7388, lot # 84H5805). The assay is coupled with α- chymotrypsin, where the ability of the protease to cleave the test peptide occurs only when the Ala-Pro bond is in trans. The conversion of the test peptide to the trans isomer in the assay is followed at 390 nm on a Beckman Model DU-650 spectophotometer. The data were collected every second with an average scanning of time of 0.5 second. Assays were carried out in 35 mM Hepes, pH 8.0, in a final volume of 400 ul, with 10 μ M α-chymotrypsin (type 1-5 from bovine Pancreas, Sigma # C-7762, lot 23H7020) and 10 nM PPiase. To initiate the reaction, 10 μl of the substrate ( 2 mM N-Succinyl-Ala- Ala-Pro-Phe-p-nitroanilide in DMSO) was added to 390 μl of reaction mixture at room temperature. PPiase assay in crude bacterial extract.

A 50 ml culture of Helicobacter pylori (strain J99) in Brucella broth was harvested at mid-log phase (OD _{600 nm} ~ 1) and resuspended in lysis buffer with the following protease inhibitors: 1 mM PMSF, and 10 μg/ml of each of aprotinin, leupeptin, pepstatine, TLCK, TPCK, and soybean trypsin inhibitor. Ther suspension was subjected to 3 cycles of freeze-thaw (15 minutes at -70 C, then 30 minutes at room temperature), followed by sonication (three 20 second bursts). The lysate was centrifuged (12,000 g x 30 minutes) and the supernatant was assayed for PPiase activity.

Results

PPI from H. pylori was expressed in E. coli using the pET-28b expression vector from Novagen (cat # 69868-1). The expressed recombinant protein was isolated from the soluble fraction of bacterial cells that had been disrupted by cavitation in a Microfluidics Cell disruption chamber. The expression levels of recombinant PPI produced 100 mg of protein. The recombinant protein could be purified to homogeneity

2+ by Ni chelate chromatography and gel filtration. On sodium dodecyl sulfate polyacrylamide gels, the recombinant protein migrates as a single band at 21 kDa, in accordance with the predicted molecular weight of 20,975 deduced from the gene sequence. The PPiase activity was assayed using the chromogenic tetrapeptide substrate succinyl-Ala-Ala-Pro-Phe-p-nitroanilide. An initial velocity of 4.9 μmole/min/mg protein was measured with the purified enzyme (Figure 5). This corresponds to a k_cat of 1.6 sec which is similar to the one obtained for the E. coli PPiase (Liu, J. and Walsh, CT. (1990) Proc.Natl Acad. Sci. USA 87:4028-4032) and the one from porcine kidney (Fischer, G. (1989) Nature 337:476-478).

9 -1 -1

The recombinant protein has a high catalytic efficiency of 2.06 X 10 M s when the assay is measured at 25 C. These values are one to two orders of magnitude higher than that observed for other characterized PPIases. However, in those studies, the ppiase assay was conducted at 10 C, which may account for the discrepency. The calalytic efficiency is very close to the 1 X 10 to 1 X 10 M s upper diffusinal limit for "kinetically perfect" enzymes (Albery, W.J. and Knowles, J.R. (1976) Biochemistry 15:5631-5640) and suggests that by at least one measure, the H. pylori PPiase is a highly effective catalyst in the cis-trans isomerisation of the Ala-Pro bond in the oligopeptide substrate. The presence of PPiase was also determined in an H. pylori extract. As with the assay for the recombinant protein, PPiase activity was detected, and was dependent on the concentration of extract added (Figure 6).

These results show that PPiase activity can be measured on either H. pylori extracts or on the recombinant protein in E. coli. The high catalytic efficiency also demonstrates that H. pylori enzymes, such as PPiase, can be expressed at high levels and in an active form in E. coli. Such high yields of purified proteins provide for the design of various high throughput drug screening assays.

IX. Cloning, purification, and characterization of the gene encoding the glutamate racemase ofH. pylori.

The Helicobacter pylori genome contains an open reading frame (ORF) of 255 amino acids that was found to have homology to the Staphylococcus haemolyticus glutamate racemase gene (dga) (NCBI Accession number U 12405) and to the E. coli murl gene which encodes glutamate racemase activity in that organism. To evaluate whether this H. pylori ORF encodes a protein with glutamate racemase activity, the gene was isolated by polymerase chain reaction (PCR) amplification cloning, overexpressed in E. coli, and the protein purified to apparent homogeneity. A simple assay for glutamate racemase activity resulting in the isomerization of D-glutamic acid to L- glutamic acid was developed to facilitate purification and for future use as a high- throughput drug screen.

The ORF in H. pylori has been found by gene disruption studies to be essential for viability ofH. pylori cells in laboratory culture (see Example VII above). Therefore, inhibition of the enzymatic activity would be expected to be lethal for the organism, and such inhibitors may have utility in antimicrobial therapy of human infectious diseases.

Cloning ofH. pylori murl gene encoding glutamate racemase

A 765 base pair DNA sequence encoding the murl gene ofH. pylori was isolated by polymerase chain reaction (PCR) amplification cloning. A synthetic oligonucleotide primer (5 '-AAATAGTCATATGAAAATAGGCGTTTTTG -3' (SEQ ID NO:1289)) encoding an Ndel restriction site and the 5' terminus of the murl gene and a primer (5'-AGAATTCTATTACAATTTGAGCCATTCT -3' (SEQ ID NO:1290)) encoding an EcoRI restriction site and the 3' end of the murl gene were used to amplify the murl gene ofH. pylori using genomic DNA prepared from the J99 strain ofH. pylori as the template DNA for the PCR amplification reactions (Current Protocols in Molecular

Biology, John Wiley and Sons, Inc. F. Ausubel et al., editors, 1994). To amplify a DNA sequence containing the murl gene, genomic DNA (25 nanograms) was introduced into each of two reaction vials containing 1.0 micromole of each synthetic oligonucleotide primer, 2.0 mM MgCl₂, 0.2 mM of each deoxynucleotide triphosphate (dATP, dGTP, dCTP & dTTP), and 1.25 units of heat stable DNA polymerases (Amplitaq, Roche Molecular Systems, Inc., Branchburg, NJ, USA) in a final volume of 50 microliters. The following thermal cycling conditions were used to obtain amplified DNA products for the murl gene using a Perkin Elmer Cetus/ GeneAmp PCR System 9600 thermal cycler:

Conditions for amplification ofH pylori murl;

Denaturation at 94°C for 2 min,

2 cycles at 94°C for 15 sec, 30°C for 30 sec and 72°C for 15 sec 23 cycles at 94°C for 15 sec, 53°C for 30 sec and 72°C for 15 sec Reactions were concluded at 72°C for 20 minutes

Upon completion of thermal cycling reactions, the amplified DNA was washed and purified using the Qiaquick Spin PCR purification kit (Qiagen, Gaithersburg, MD, USA). The amplified DNA sample was subjected to digestion with the restriction endonucleases, Ndel and EcoRI (New England Biolabs, Beverly, MA USA) (Current Protocols in Molecular Biology, Ibid). The DNA samples from each of two reaction mixtures were pooled and subjected to electrophoresis on a 1.0% SeaPlaque (FMC BioProducts, Rockland, ME, USA) agarose gel. DNA was visualized by exposure to ethidium bromide and long wave uv irradiation. Amplified DNA encoding the H. pylori murl gene was isolated from agarose gel slices and purified using the Bio 101 GeneClean Kit protocol (Bio 101 Vista, CA, USA).

Cloning ofH. pylori DNA sequences into the pET-23 prokaryotic expression vector.

The pET-23b vector can be propagated in any E. coli K-12 strain, e.g., ΗMS174, HB101, JM109, DH5α, etc., for the purpose of cloning or plasmid preparation. Hosts for expression include E. coli strains containing a chromosomal copy of the gene for T7

RNA polymerase. These hosts are lysogens of bacteriophage DE3, a lambda derivative that carries the lad gene, the lacUV5 promoter and the gene for T7 RNA polymerase.

T7 RNA polymerase is induced by addition of isopropyl-B-D-thiogalactoside (IPTG), and the T7 RNA polymerase transcribes any target plasmid, such as pET-28b, carrying its gene of interest. Strains used in our laboratory include: BL21(DE3) (Studier, F.W.,

Rosenberg, A.H., Dunn, J.J., and Dubendorff, J.W. (1990) Meth. Enzymol. 185, 60-89).

The pET-23b vector (Novagen, Inc., Madison, WI, USA) was prepared for cloning by digestion with Ndel and EcoRI (Current Protocols in Molecular Biology, Ibid). Following digestion, the amplified, agarose gel-purified DNA fragment carrying the murl gene was cloned (Current Protocols in Molecular Biology, Ibid) into the previously digested pET-23b expression vector. Products of the ligation reaction were then used to transform the BL21(DE3) strain of E. coli.

Transformation of competent bacteria with recombinant plasmids

Competent bacteria, E coli strain BL21 or E. coli strain BL21(DE3), were transformed with recombinant pET23-murI expression plasmid carrying the cloned H. pylori sequence according to standard methods (Current Protocols in Molecular, Ibid). Briefly, 1 microliter of ligation reaction was mixed with 50 microliters of electrocompetent cells and subjected to a high voltage pulse, after which, samples were incubated in 0.45 milliliters SOC medium (0.5% yeast extract, 2.0 % tryptone, 10 mM NaCl, 2.5 mM KCl, 10 mM MgCl₂, 10 mM MgSO₄ and 20 mM glucose) at 37°C with shaking for 1 hour. Samples were then spread on LB agar plates containing 100 microgram ml ampicillin for growth overnight. Transformed colonies of BL21 were then picked and analyzed to evaluate cloned inserts as described below.

Identification of recombinant pET expression plasmids carrying H pylori sequences Individual BL21 clones transformed with recombinant pET-23- wr/were analyzed by PCR amplification of the cloned inserts using the same forward and reverse primers, specific for each H. pylori sequence, that were used in the original PCR amplification cloning reactions. Successful amplification verified the integration of the H. pylori sequences in the expression vector (Current Protocols in Molecular Biology, Ibid).

Isolation and Preparation of plasmid DNA from BL21 transformants

Colonies carrying pET-23-wwr/ vectors were picked and incubated in 5 mis of LB broth plus 100 microgram/ml ampicillin overnight. The following day plasmid DNA was isolated and purified using the Qiagen plasmid purification protocol (Qiagen Inc., Chatsworth, CA, USA).

Cloning and expression of the E. coli groE operon

It has been demonstrated that coexpression of the E. coli murl gene with the genes in the E. coli groE operon reduces the formation of insoluble inclusion bodies containing recombinant glutamate racemase (Ashiuchi, M., Yoshimura, T., Kitamura, T., Kawata, Y., Nagai, J., Gorlatov, S., Esaki, N. and Soda, K., 1995, J. Biochem. 117, 495-498). The groE operon encodes two proteins, GroES (97 amino acids) and GroEL (548 amino acids), which are molecular chaperones. Molecular chaperones cooperate to assist the folding of new polypeptide chains (F. Ulrich Hartl , 1996, Nature London 381, pp. 571-580). The 2210 bp DNA sequence encoding the groE operon of E. coli (NCBI

Accession number X07850) was isolated by polymerase chain reaction (PCR) amplification cloning. A synthetic oligonucleotide primer (5'-GCGAATTCGATCAG AATTTTTTTTCT-3' (SEQ ID NO: 1291)) encoding an EcoRI restriction site and the 5' terminus of the groE operon containing the endogenous promoter region of the groE operon and a primer (5 '-ATAAGTACTTGTGAATCTTATACTAG -3 ' (SEQ ID

NO: 1292)) encoding a Seal restriction site and the 3' end of the groEL gene contained in the groE operon were used to amplify the groE operon of E. coli using genomic DNA prepared from E. coli strain MG1655 as the template DNA for the PCR amplification reactions (Current Protocols in Molecular Biology, Ibid). To amplify a DNA sequence containing the E. coli groE operon, genomic DNA (12.5 nanograms) was introduced into each of two reaction vials containing 0.5 micromoles of each synthetic oligonucleotide primer, 1.5 mM MgCl , 0.2 mM each deoxynucleotide triphosphate (dATP, dGTP, dCTP & dTTP) and 2.6 units heat stable DNA polymerases (Expanded High Fidelity PCR System, Boehringer Mannheim, Indianapolis, Indiana) in a final volume of 50 microliters. The following thermal cycling conditions were used to obtain amplified DNA products for the groE operon using a Perkin Elmer Cetus/ GeneAmp PCR System 9600 thermal cycler:

Conditions for amplification and cloning of the E. coli groE operon;

Denaturation at 94°C for 2 min,

2 cycles at 94°C for 15 sec, 30°C for 30 sec and 72°C for 2 min 23 cycles at 94°C for 15 sec, 55°C for 30 sec and 72°C for 2 min Reactions were concluded at 72°C for 8 minutes

Upon completion of thermal cycling reactions, the amplified DNA was washed and purified using the Qiaquick Spin PCR purification kit (Qiagen, Gaithersburg, MD, USA). The amplified DNA sample was subjected to digestion with the restriction endonucleases, EcoRI and Seal (New England Biolabs, Beverly, MA USA) (Current Protocols in Molecular Biology, Ibid). The DNAs from each of two reaction mixtures were pooled and subjected to electrophoresis in a 1.0% SeaPlaque (FMC BioProducts, Rockland, ME, USA) agarose gel. DNA was visualized by exposure to ethidium bromide and long wave uv irradiation. DNA contained in slices isolated from the agarsoe gel was purified using the Bio 101 GeneClean Kit protocol (Bio 101 Vista, CA, USA).

A DNA fragment, EcoRI To Seal, containing the E. coli groE operon was cloned into the corresponding sites of the pACYC184 expression vector (New England Biolabs, Beverly, MA, USA) to make pACYC 184-groE. The BL21 (DΕ3) strain of E. coli was transformed with pACYC-groE. A tetracycline-resistant transformant overexpressing proteins of M_r ~ 14,000 (GroES) and M_r ~ 60,000 (GroEL) was isolated.

Transformation ofE. coli strain BL21(DE3) carrying the pACYC-groE plasmid ofE. coli.

Competent bacteria derived from a clone of strain BL21(DE3) carrying the pACYC-groE plasmid were transformed with 50 nanograms of pET23-murI plasmid

DNA, isolated as described above (Current Protocols in Molecular Biology, Ibid). A clone of BL21(DΕ3) carrying both the pACYC-groE expression plasmid and the pΕT- 2 -murl plasmid was isolated and used for expression of recombinant glutamate racemase as described below.

Expression of recombinant H pylori murl

A bacterial clone of BL21(DΕ3) carrying both the pACYC-groE expression plasmid and the pEI-23-murI plasmid was cultured in LB broth supplemented with 1.0 mM D,L-glutamic acid and 100 microgram/ml ampicillin and 10 micrograms/ml tetracycline at 30°C until an optical density at 600 nM of 0.5 to 1.0 O.D. units was reached, at which point, isopropyl-beta-D-thiogalactoside (IPTG) was added to the culture at a final concentration of 1.0 mM. Cells were cultured overnight to induce gene expression of the H. pylori recombinant DNA constructions .

After induction of gene expression with IPTG, bacteria were pelleted by centrifugation in a Sorvall RC-3B centrifuge at 3000 x g for 20 minutes at 4°C. Pellets were resuspended in 50 milliliters of cold 10 mM Tris-ΗCl, pΗ 8.0, 0.1 M NaCl and 0.1 mM ΕDTA (STΕ buffer). Cells were then centrifuged at 2000 x g for 20 min at 4°C. Pellets were weighed (average wet weight = 6 grams/liter) and processed to purify recombinant protein as described below.

Purification of soluble glutamate racemase

All steps were carried out at 4°C. Cells were suspended in 4 volumes of lysis buffer (50 mM Potassium phosphate, pΗ 7.0, 100 mM NaCl, 2 mM ΕDTA, 2 mM

ΕGTA, 10% glycerol, 10 mM D,L-glutamic acid, 0.1 % β-mercaptoethanol, 200 μg/ ml lysozyme, 1 mM PMSF, and 10 ug/ml each of leupeptin, aprotinin, pepstatin. L-l- chloro-3-[4-tosylamido]-7-amino-2-heptanone (TLCK), L-l-chloro-3-[4-tosylamido]-4- phenyl-2-butanone (TPCK), and soybean trypsin inhibitor, and ruptured by three passages through a small volume microfluidizer (Model M-l 10S, Microfluidics International Corporation, Newton, MA). The resultant homogenate was diluted with 1 volume of buffer A (10 mM Tris-HCl pH 7.0, 0.1 mM EGTA, 10 % glycerol, 1 mM DL- Glutamic acid, 1 mM PMSF, 0.1% beta-mercaptoethanol), made 0.1 % Brij-35, and centrifuged (100,000 x g, 1 h) to yield a clear supernatant (crude extract).

After filtation through a 0.80-um filter, the extract was loaded directly onto a 20 ml Q-Sepharose column pre-equilibrated in buffer A containing 100 mM NaCl and 0.02 % Brij-35. The column was washed with 100 ml (5 bed volumes) of Buffer A containing 100 mM NaCl and 0.02 % Brij-35, then developed with a 100-ml linear gradient of increasing NaCl (from 100 to 500 mM) in Buffer A. A band of M_r = 28,000 corresponding to glutamate racemase, the product of the recombinant H pylori murl gene, eluted at a gradient concentration of approximately 200-280 mM NaCl. Individual column fractions were then characterized for glutamate racemase activity (see below for description of assay) and the protein profile of the fractions were analyzed on 12 % acrylamide SDS-PAGE gels.

Fractions containing glutamate racemase were pooled, brought to 70% saturation with solid (NH₄)₂SO₄, stirred for 20 min, and then centrifuged at 27,000 x g for 20 min. The resulting pellet was resuspended in lysis buffer to a final volume of 8 ml and loaded directly onto a 350-ml column (2.2 x 92 cm) of Sephacryl S-100HR gel filtration medium equilibrated in buffer B (10 mM Hepes pH 7.5, 150 mM NaCl, 0.1 mM EGTA, 10% glycerol, 1 mM D,L-glutamatic acid, 0.1 mM PMSF, 0.1 % beta-mercaptoethanol) and run at 30 ml/h. Fractions found to contain a glutamate racemase activity were pooled, and 0.5 volume of buffer C (10 mM Tris pH 7.5, 0.1 mM EGTA, 10% glycerol, 1 mM D,L-glutamic acid, 0.1 mM PMSF, 0.1 % B-mercaptoethanol)was added (to reduce the NaCl concentration to 100 mM), and loaded onto a MonoQ 10/10 high- pressure liquid chromatography column equilibrated in buffer C containing 100 mM NaCl. The column was washed with 5 bed volumes of this buffer and developed with a 40 ml linear gradient of increasing NaCl (from 100 to 500). Glutamate racemase eluted as a sharp peak at 310 mM NaCl. Fractions containing a glutamate racemase activity were pooled, concentrated by dialysis against storage buffer [50% glycerol, 10 mM 3- (N-morpholino-propanesulfonic acid (MOPS) pH 7.0, 150 mM NaCl, 0.1 mM EGTA, 0.02 % Brij-35, 1 mM dithiothreitol (DTT)], and stored at -20°C. Assaysfor glutamate racemase activity.

Conversion of D-glutamate to L-glutamate (two enzyme coupled assay)

The activity of glutamate racemase, interconversion of the enantiomers of glutamic acid, was measured using D-glutamic acid as substrate. The method of Gallo and Knowles (Gallo, K.A. and Knowles, J.R., 1993, Biochmistry 32, 3981-3990) that was used to measure the glutamate racemase activity of Lactobacillus fermenti was adapted for the measurement of glutamate racemase activity of the H. pylori murl gene product isolated as a recombinant protein from E. coli. In this assay, the measurement of the activity of glutamate racemase is linked to an OD change in the visible range in a series of coupled reactions to the activities of L-glutamate dehydrogenase (reduction of NAD to NADΗ) and diaphorase (reduction of the dye p-iodonitrotetrazolium violet, INT). Initial rates were determined by following the increase in absorbance at 500 nm in a reaction volume of 200 μl containing 50 mM Tris-ΗCl, pΗ 7.8, 4% v/v glycerol, 10 mM NAD, 2 mM INT, 60 Units/ml L-glutamate dehydrogenase, 5 Units/ml diaphorase, and varying concentrations of either substrate (from 0.063 mM to 250 mM D-glutamic acid) or purified enzyme (from lμg to 50 μg). After a preincubation of all reagents except either the substrate (D-glutamic acid) or the enzyme (murl gene product) for a period of 5 minutes, reactions were initiated by adding the missing ingredient (i.e., the enzyme or the subtrate, as required), and the increase in optical density at 500 nm was measured in a Microplate Spectophotometer System (Molecular Devices, Spectra MAX 250). Measurements were followed for 20 minutes, and initial velocities were derived by calculating the maximum slope for the absorbance increases. The coupled reaction can be summarized as shown below:

1) D-glutamate — >^■ L-glutamate glutamate racemase

2) L-glutamate + Η₂O + NAD⁺ → 2-oxoglutarate + NH₃ + NADH L-glutamate dehydrogenase

3) NADH + INT → NAD⁺ + formazan (color) diaphorase

Conversion of D-glutamate to L-glutamate (single enzyme coupled assay)

In this assay, the conversion of D-glutamic acid to L-glutamic acid is coupled to the conversion of L-glutamic acid and NAD by L-glutamate dehydrogenase to 2- oxoglutarate, ammonia. The production of NADH is measured as an increase of absorbance at 340 nm (the reduction of NAD⁺ to NADH) at 37°C. The standard assay mixture (adapted from Choi, S-Y„ Esaki, N., Yoshimura, T., and Soda, K., 1991 , Protein Expression and Purification 2, 90-93) contained 10 mM Tris-HCl, pH 7.5, 5 mM NAD+, 5 Units/ml L-glutamate dehydrogenase, varying concentrations of the substrate D-Glutamic Acid (0.063 mM to 250 mM), and the purified recombinant H. pylori enzyme glutamate racemase (1 μg to 50 μg). The reaction was started by the addition of either the substrate D-glutamic acid or the recombinant glutamate racemase after a preincubation at 37°C for 5 minutes with all of the other assay ingredients. The change in absorbance at 340 nm was measured in a Spectra MAX 250. Initial velocities were derived from the initial slopes. The coupled reactions can be summarized as shown below:

1) D-glutamate - L-glutamate glutamate racemase

2) L-glutamate + H₂O + NAD⁺ → 2-oxoglutarate + NH₃ + NADH

L-glutamate dehydrogenase

Results

1) Expression of the H. pylori murl gene in E. coli cells

To examine its biochemical properties, the H. pylori glutamate racemase was overexpressed in E. coli and purified. In the presence of the E. coli chaperones GroES and GroEL, the glutamate racemase was expressed as a soluble protein. About 20 mg of soluble Murl was produced per liter of culture as judged by intensity of the protein band after SDS-PAGE. No band corresponding to the molecular weight of murl protein was seen in control gel lanes containing extracts from cells transformed with the pET vector lacking a murl insert. Addition of 1 mM DL-glutamic acid during cultivation of the expressing cells increased the apparent expression level by about five-fold.

2) Purification of recombinant H. pylori murl protein

Murl was purified by cation exchange chromatography and gel filtration. Upon SDS-PAGE analysis, the purified protein migrated as a single polypeptide species with an apparent mass 29 kDa which is consistent with the predicted mass of 28,858. 3) Kinetic properties of recombinant H. pylroi murl enzyme Kinetic constant for recombinant glutamate racemase were estimated by assaying its activity at various concentrations of protein and D-glutamic acid as described above. Purified recombinant H. pylori glutamate racemase exhibits a V_max of - 300 nmoles/min mg protein (kcat = 8.6 min -1) and a K_m of -100 μM for D-glutamate. Although the Vmax value is lower than that observed for highly purified glutamate racemase from some other bacterial species, its Km for D-glutamic acid is higher than that observed for the enzyme from most other species, resulting in a catalytic efficiency (kcat/Km) which is typical of purified preparation from E. coli and P. Pentococcus.

4) Characterization of Murl: Inhibition by L-serine-O sulfate The H. pylori glutamate racemase was tested for inactivation with a sucuide inhibitor, L-serine-0 sulfate, which is known to inhibit murl from E. coli. The enzyme was incubated in the presence of 20 mM L-serine-O sulfate, and at different times interval, aliquots were removed to determine residual activity. The initial velocity of purified recombinant H. pylroi murl protein was determined in the single enzyme coupled asssay following incubation with the inhibitor L-serine-O-sulfate (LSOS) at 20 mM for the times indicated on the x-axis. The control was incubated in an identical manner but without LSOS. As shown in Figure 7, the H. pylori glutamate racemase can be readily inactivated by the inhibitor.

Future application of the glutamate racemase activity in high throughput drug screening assays.

The assays for measurement ofH. pylori glutamate racemase activity described above have been carried out in 96-well plates in which multiple reactions were conducted simultaneously. Measurements of activity in a multi-well format are readily amenable to scale-up to permit rapid analysis of numerous compounds for inhibition of the glutamate racemase activity. Compunds which inhibit the activity of glutamate racemase may have application as novel antibiotics and may be suitable for the treatment and eradication of bacterial (e.g., H. pylori) infections in humans. Known inhibitors of glutamate racemase, such as L-serine-O-sulfate, can be used to calibrate high throughput screens of new compound libraries to facilitate identification of new compounds with properties suitable for in vivo human therapeutics. EQUIVALENTS

Those skilled in the art will recognize, or be able to ascertain using no more than routine experimentation, many equivalents to the specific embodiments and methods described herein. Such equivalents are intended to be encompassed by the scope of the following claims.

SEQUENCE LISTING

GENERAL INFORMATION:

(i) APPLICANT:

(A) NAME: Astra Aktiebolag

(B) STREET: S-151 85

(C) CITY: Sodertalje

(D) STATE:

(E) COUNTRY: Sweden

(F) POSTAL CODE (ZIP)

(ii) TITLE OF INVENTION: NUCLEIC ACID AND AMINO ACID SEQUENCES RELATING TO HELICOBACTER PYLORI AND VACCINE COMPOSITIONS THEREOF

(iii) NUMBER OF SEQUENCES: 1298

(iv) CORRESPONDENCE ADDRESS:

(A) ADDRESSEE: LAHIVE & COCKFIELD

(B) STREET: 60 State Street, Suite 510

(C) CITY: Boston

(D) STATE: Massachusetts

(E) COUNTRY: USA

(F) ZIP: 02109-1875

(v) COMPUTER READABLE FORM:

(A) MEDIUM TYPE: CD/ROM ISO9660

( B ) COMPUTER :

(C) OPERATING SYSTEM:

(D) SOFTWARE:

(vi) CURRENT APPLICATION DATA:

(A) APPLICATION NUMBER:

(B) FILING DATE:

(vii) PRIOR APPLICATION DATA:

(A) APPLICATION NUMBER: US 08/625,811

(B) FILING DATE: 29-MAR-1996

(viii) PRIOR APPLICATION DATA:

(A) APPLICATION NUMBER: US 08/758,731

(B) FILING DATE: 02-APR-1996

(ix) PRIOR APPLICATION DATA:

(A) APPLICATION NUMBER: US 08/736,905

(B) FILING DATE: 25-OCT-1996

(x) PRIOR APPLICATION DATA:

(A) APPLICATION NUMBER: US 08/738,859

(B) FILING DATE: 28-OCT-1996 (xi) PRIOR APPLICATION DATA:

(A) APPLICATION NUMBER: US 08/761,318

(B) FILING DATE: 06-DEC-1996

(xii) ATTORNEY/AGENT INFORMATION:

(A) NAME: Mandragouras , Amy E.

(B) REGISTRATION NUMBER: 36,207

(C) REFERENCE/DOCKET NUMBER: GTN-009C2PC

(xiii) TELECOMMUNICATION INFORMATION:

(A) TELEPHONE: (617)227-7400

(B) TELEFAX: (617)227-5941

(2) INFORMATION FOR SEQ ID NO 1.

(l) SEQUENCE CHARACTERISTICS

(A) LENGTH 288 base pairs

(B) TYPE, nucleic acid

(C) STRANDEDNESS . double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...288

(xi) SEQUENCE DESCRIPTION: SEQ ID NO : 1 :

GAGAGGATAA AAAGGAGAGC GGTGATGAAA AAAATCGTTG TGAGTTTATG CGTGGCGTTA 60

GGTTTTTTAA GCGCGGATCC AGCGCAGGCC AATAAAGCGA TCAGTGATGC GGATTTGATT 120

GAAGAGATAA GGGACTTGAA AAAAATCATC AGCGCACAAA ACACGGAGAT TAACCAATTA 180

AGAAAAGTGC AAGAAGTCTT ATCTGGGCAA TTAGGGGACA TGCGTAAGGA TATATTAAGC 240

ACTAGAGATT ACTGTATCAG CTTAAGGCCT TATATTTATA ATTGGCGC 288

(2) INFORMATION FOR SEQ ID NO : 2 :

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 903 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...903

(xi) SEQUENCE DESCRIPTION: SEQ ID NO : 2 :

AACGCTTGGA ATGATTTCGT TAAAAGCGGA TCTTTAGGGC CTTTTAGCAA TGGTTATTAT 60

GAGCATAAAA CTATTCGTTT AAACCCAGAA CAAAATTTAA TCGTCTTAAG CCACTACCTC 120

AAGCTTTTAG AAATCCAAAG GGAAGCGGCG AAAATGACCG CTATTTTTGG GGCCAAACAA 180

CCTCACCCAC AAAGCCTAAC GGTGGGGGGT GTTACGAGTG TCATGGATAT ATTGGATCCA 240

ACAAGGTTGG CTGAATGGAA GAGCAAGTTT GAAGTGGTGG CTAATTTTAT CAACCATGCT 300 TACTACCCTG ATTTGGTGAT GGCAGGCGAA ATGTTCGCTA ACGAACCATC TGTTATTAAA 360

GGCTGTGGTT TAAGGAATTT TATCGCTTAT GAAGAAGTGT TGCTTGGGAA GGATAAATAC 420

CTTTTGAGTA GTGGGGTGGT GCTTGATGGG GATATTTCTA AATTACACCC CATTGATGAA 480

AGTTTGATTA AAGAAGAGGT TACGCATTCT TGGTATCAAT ATGAAGACAC TAAAGAAGTG 540

CAACTCCACC CTTATGACGG GCAAACTAAC CCGCATTATA CCGGTTTAAA AGACGGCGAG 500

AGCGTGGGGA TTGAAAATAA AATAATCCCT GCTAAAGTGC TTGACACTAA GGATAAATAT 660

TCTTGGATAA AATCGCCCAG ATACGATAGT AAGCCCATGG AAGTAGGGCC TTTAAGTTCC 720

GTAGTGGTAG GTTTAGCGGC GAAAAACCCT TATGTTACTG AAGTGGCTAC TAAATTTTTA 780

AAAGACACGA AACTGCCTTT AGAGGCGTTG TTTTCAACGC TTGGGCGCAC AGCTGCAAGG 840

TGTATTGAAG CTAAGACTAT CGCTGATAAT GGTCTTTTGG CGTTTGACGC GTTAGTGGAA 900

ATC 903

(2) INFORMATION FOR SEQ ID NO : 3 :

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 507 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...507

(xi) SEQUENCE DESCRIPTION: SEQ ID NO : 3 :

GGGATTAACA TGTCAAAAAA AATCGTAGTC GATCCTATCA CTAGGATTGA GGGGCATTTA 60

AGGATTGAGG TGATCGTAGA TGATGATAAT GTGATCACCG ATGCGTTTTC TTCTTCTACG 120

CTTTTTAGGG GGCTAGAAAC GATCATTAAG GGCAGAGACC CACGAGATGC AGGCTTTATC 180

GCTCAAAGGA TTTGTGGGGT ATGCACTTAT TCGCATTATA AAGCCGGTGT TACTGCGGTA 240

GAAAACGCTT TAGGAATCAC TCCCCCATTA AACGCGCAAT TGGTGCGATC TTTGATGAAC 300

ATGGCGTTGC TTTTTCACGA TCATGTGGTG CATTTCTATA CTTTGCATGG GCTTGATTGG 360

TGCGATATTT TGAGCACTTT AAAAGCTGAT CCCATTCAAG CAGCAAAACT TTCTTTCAAA 420

TACAGCCCTT ATCCCATTAA TACCGGTGCG GGGCGAATTA AAAGCGGTTC TAAAACGCTT 480

GGAATGATTT CGTTAAAAGC GGATCTT 507

(2) INFORMATION FOR SEQ ID NO : 4 :

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 555 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...555

(xi) SEQUENCE DESCRIPTION: SEQ ID NO : 4 :

TGGCTATGGT TACACCAAAG AATGAGTCAA AAAATCCTAA TTTTAGGCAT TGGCAATATC 60

CTTTTTGGCG ATGAAGGGAT TGGGGTGCAT CTAGCCCACT ACCTCAAAAG GAATTTTTCT 120

TTTTTCCCTA GCGTGGATAT TGTGGATGGG GGGACTATGG CTCAGCAACT CATTCCTTTA 180

ATCACTTCGT ATGAAAAGGT TTTGATTTTA GATTGCGTGA GCGCTAAAGG CGTTGAAATT 240

GGCTCAGTTT ATGCCTTTGA TTTTAAGGAC GCTCCTAAAG AAATCACATG GGCTGGGAGT 300

GCGCATGAAG TGGAAATGCT GCACACTTTA AGGCTCACGG AGTTTTTAGG GGATTTGCCT 360

AAAACTTTTA TCGTGGGGCT TGTGCCTTTT GTGATAGGGA GCGAGACCAC TTTCAAGCTT 420

TCAAGCGAAA TGTTAAACGC TTTAGAAACA GCCCTAAAAG CCATAGAAAC CCAACTCAAC 480

GCATGGGGAG TTAAAATGCA ACGCACCGAT CATATTGCCC TAGATTGTAT CGCTGAACTC 540

TCTTATAAGG GTTTT 555

(2) INFORMATION FOR SEQ ID NO : 5 :

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 324 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) AN I-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...324

(xi) SEQUENCE DESCRIPTION: SEQ ID NO : 5 :

TATCAAATCT TAAACCAAAG AAAAACCATG AAAAAAGTCC TCTTACTAAC TCTCTCTCTC 60

TCTCTCTCGT TTTGGCTCCA CGCTGAAAGG AACGGATTTT ATTTAGGTTT AAATTTTGCA 120

GAAGGAAGCT ATATTCAAGG ACAAGGTAGC ATCGGCGAAA AAGCTTCAGC AGAAAACGCC 180

TTAAATCAAG CGATCAATAA CGCACAAAAT TCATTATTCC CTAACACACA AGCCATAAGA 240

GATGTGCAAA ACGCCTTAAA TGCAGTGAAA GATTCAAACA AAATCGCTAA CCGATTCGCA 300

GGAAATGGTG GATCGGGCGG TATT 324

(2) INFORMATION FOR SEQ ID NO : 6 :

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 384 base pairs

(B) TYPE: nucleic acid (C) STRANDEDNESS. double

(D) TOPOLOGY circular

(11) MOLECULE TYPE DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE.

(A) NAME/KEY: m sc_feature

(B) LOCATION 1...384

(xi) SEQUENCE DESCRIPTION: SEQ ID NO : 6 :

CGCGTTAGTG GAAATCTAAA GAGCGATCAA AGCACTTGTG CTCCTTATCA TATTGATAAA 60

AATCAAGAAT ATAAAGGGCG CTACATTGGT CAAGTGCCAA GGGGCATGTT AAGCCATTGG 120

GTGCGTATTA AAAACGGCGT GGTGGAAAAT TATCAAGCGG TAGTGCCTTC CACTTGGAAT 180

GCAGGGCCTA GAGATTCTAA AAATCAAAGG GGGGCTTATG AAATGAGCTT GATTGGCACT 240

AAAATCGCTG ATTTAACCCA GCCTTTAGAA ATCATTAGGA CTATCCATTC TTTTGATCCA 300

TGCATCGCAT GCTCAGTGCA TGTGATGGAT TTTAAAGGGC AGTCTTTGAA CGAGTTCAAA 360

GTAGAGCCTA ATTTCGCTAA ATTC 384

(2) INFORMATION FOR SEQ ID NO : 7 :

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 258 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...258

(xi) SEQUENCE DESCRIPTION: SEQ ID NO : 7 :

TTATACCAGA ACGACAAGGG TTTTAAAACA GAACTGCGCA TTTTGAGCGT GTTTATCGTG 60

GAATTTTTGG TGAATATTCT AGGGTTTATG TTGGCTCATA TGCTTCATTT CTGGTTTTTA 120

AGGTGCGTTA AAGCTTTAGC GTGGCTCATG AAAACTTTTG ATAGGCGCCG TTATTTTGAC 180

GCTAAGGCCA ATTTGGATTT TGTGTTTGGA GATTCTAAAA GCGAAGAAGA GAAAAAAAGG 240

ATCATTAAAA AAGGGGTA 258

(2) INFORMATION FOR SEQ ID NO : 8 : (1) SEQUENCE CHARACTERISTICS

(A) LENGTH: 201 base pairs

(B) TYPE- nucleic acid

(C) STRANDEDNESS double

(D) TOPOLOGY- circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL. NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...201

(xi) SEQUENCE DESCRIPTION. SEQ ID NO : 8 :

TACAAAAAAG GAAATCAAAT AATGAATATT CAAACAAAGA AAAGATTTTT AGCAAATTTA 60

TTGCTTTTTA GCCTGTTTTC TTGCCTTAAG GCTGAAACCC TTTCAGAAGA CCATCAAATC 120

CTGTTGAGTT CAGACGCTTT CCATAGAGGG GATTTTGCCA CCGCTCAAAA AGGCTATATG 180

AATCTCTATA GAGCAAACCA A 201

(2) INFORMATION FOR SEQ ID NO : 9 :

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 768 base pairs

(B) TYPE: nucleic ac d

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...768

(xi) SEQUENCE DESCRIPTION: SEQ ID NO : 9 :

TTGTGTTTGA AACTCTTAAT TTGGAATTTT AAGGAGCATT CTTTGAAAGT CAATTTCTTT 60

GCCACTTGTC TAGGAGCAGC TATTTATAGC AACGCATCGC TTAACGCTAT CAAATTACTC 120

CGCAAGGAAA ATTTGGAAGT GGTTTTTAAA AAAGACCAGA CATGTTGTGG CCAGCCAAGC 180

TACAACTCAG GATACTATGA AGAGACTAAA AAAGTCGTTT TATACAATAT CAAACTTTAT 240

TCCAATAACG ACTACCCTAT TATTTTGCCT AGCGGTTCAT GCACAGGGAT GATGCGGCAT 300

GATTATTTGG AATTGTTTGA AGGGCATGCG GAATTTAACA TGGTTAAAGA TTTTTGCTCT 360

AGGGTGTATG AATTGAGCGA GTTTTTGGAT AAAAAATTGC AAGTCAAATA CGAAGATAAG 420

GGCGAACCTC TCAAAATCAC ATGGCATTCT AATTGCCATG CCTTAAGGGT GGCTAAAGTG 480 ATTGACTCGG CGAAAAATCT CATCAGACAG CTTAAAAATG TGGAACTCAT TGAATTGGAA 540

AAAGAAGAAG AATGCTGCGG GTTTGGGGGG ACTTTTTCAG TTAAAGAGCC TGAAATTTCA 600

GCGGTTATGG TCAAAGAAAA GATTAAAGAC ATAGAGAGCC GTCATGTGGA TGTGATCGTT 660

TCAGCGGATG CTGGGTGCTT GATGAATATC AGCACCGCTA TGCAAAAAAT GGGCTCTTTG 720

ACAAAACCCA TGCATTTTTA TGACTTTTTA GCCTCAAGGC TTGGACTT 768

(2) INFORMATION FOR SEQ ID NO: 10:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 765 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...765

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 10:

ATGAAAAAGA TTTTTTTAGG TATGGCATTA GCCTTTAGTG TGTCCATGGC AGAAAAAAGC 60

GGCGCGTTTT TAGGAGGGGG GTTTCAA AT TCTAATTTAG AAAACCAAAA CACCACCCGC 120

ACCCCAAGCG CTAACAATAA CACCCCGATA AACACTTCAA TGTTTGGCAA CAATCAAGCG 180

GCTCCAGCCC AAGAAACGCC AAGCGTGATC AACACCAATA ATTACGGGCA AATGTATGGG 240

GTAGATGCGA TGGCAGGGTA TAAGTGGTTC TTTGGCAAAA CCAAACGCTT TGGCTTTAGG 300

ACTTATGGAT ACTACAGCTA TAACCATGCG AATTTGAGCT TTGTAGGCAG TAAGCTTGGA 360

ATCATGGATG GCGCATCTCA AGTGAATAAC TTCACTTATG GCGTGGGCTT TGATGCGCTC 420

TATAACTTCT ATGAAAGCAA AGAGGGCTAT AACACAGCAG GGTTGTTCGT GGGCTTTGGA 480

TTAGGAGGGG ATTCGTTTAT CGTTCAAGGA GAGAGCTACT TGAAATCTCA GATGCAAATT 540

TGCAACAACA CCGCCGGCTG TTCAGCGAGC ATGAACACGA GCTACTTCCA AATGCCTGTG 600

GAATTTGGTT TTAGGAGCAA TTTCTCTAAA CACAGCGGGA TTGAAGTGGG CTTTAAATTG 660

CCTTTATTTA CCAACCAATT CTATAAAGAA AGGGGCGTAG ATGGATCGGT AGATGTGTTC 720

TATAAAAGGA ATTTCTCTAT CTATTTTAAC TACATGATCA ACCTC 765

(2) INFORMATION FOR SEQ ID NO: 11:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 654 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) AN I- SENSE: NO (vi) ORIGINAL SOURCE:

(A) ORGANISM- Helicobacter pylori

(ix) FEATURE.

(A) NAME/KEY: m sc_feature

(B) LOCATION 1...654

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 11:

GCATGTGAAA TTAGAGCATG GGCGTTTGAT AGAATGTTAA GGGTTTTAAG CGTTGGTGTT 60

GTTTTTATTT TACTAGGGTG TCAGTTTTTC AACAAAACGA CTCTGCATTT AAAATATAAG 120

GATTACCCCA AAAACAGCCC TTTAAAAACC GCTTCCACTT TAACCCCCCC TAAAATCTTT 180

TTTAACGCTC ATTTTGTGCC GCCCTTTTAC CAAAAAGAAT TTAAAAAAGC GCTCGCCCAG 240

CAAATCGCTT ATTTTTTAAA GGATAAAAGC GCTCTCACTT TCAATATTTC AGGCAATGTT 300

TTTTTTTCTT TTGAAGAGAG TCCTAAGGAT TTAAAAGCCA TTAAAGAAAG GCTTAAAAAG 360

ACGATTGAGC CTAACACTGA CCCAAAAGCC GTCATGCGTT TTTTAAACCT TCAAGCGAGC 420

TTGATTTTAG AATGTGTCCC ACAAACCGCT TGCCCATTTG ACACCCTTTT AATCCCCACC 480

GCTCTCAGCG TGCCTATTGA TTACGCCAAT CGTTTGGGCG ATAACCCCTC TCTTTTTCCC 540

CAAGAAGATA AATCCTATCA TAACGCTTTA ATCAAAGCCC TTAATAAGGC TTACTATTCT 600

CTTATGGAGG GTTTAGAAAA GCGTTTGAAC GCTATAGAAA ATGCGGCATG GCTT 654

(2) INFORMATION FOR SEQ ID NO: 12:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 372 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...372

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 12:

ACGATCCAAG AAAGGCTTTA CCGCCATGAA ATCAGCCGCT TGCAGGTAAA GACTGATGAA 60

ACTTTAAAAC TCATTAAAGA AGCCAAAAAG CGTTTGAATT ATAACGATGA TATACGAGAT 120

GTTTTGCAAG GGCTTTTGAA TATTGTGCCG GATCTTATCA CCATTAATAG CATTGAAATA 180

GACCAACAAA GCGTGGTGGT TAGCGGTAAA ACCCCCTCTA AAGAAGCCTT TTACTTTTTG 240

TTTCAAAACA AACTAAACCC CATGTTTGAT TATTCTAGGG CGGAATTTTT CCCTTTAAGC 300

GACGGGTGGT TTAATTTTGT CTCCACCAAC TTTTCTAATT CCTTACTGAT AAAAAACCCG 360

GAGTCTATTA AA 372

(2) INFORMATION FOR SEQ ID NO: 13:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1134 base pairs

(B) TYPE: nucleic acid (C) STRANDEDNESS double

(D) TOPOLOGY circular

(11) MOLECULE TYPE DNA (genomic)

(ill) HYPOTHETICAL. NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...1134

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 13:

ATCTCTATAG AGCAAACCAA TAAAGTGGTG TATGCTAAAG AGGCGGCCAT TTCAGCGGCG 60

AGTTTAGGGG ACATTAAAAC CGCTATGCAT TTAGCCATGC TTTATCAAAA AATCACCAAT 120

AATCGTAACG ATGTTTCTAT CAATAAGATT TTAGTGGATG GCTATGCACA AATGGGGCAG 180

ATTGATAAGG CGATTGAACT ATTACACAAG ATTCGTAAGG AAGAAAAAAC CATAGCCACA 240

GACAATGTGT TAGGGACTTT GTATTTGACT CAAAAGCGTT TGGATAAGGC TTTCCCGTTG 300

TTGAATAAGT TTTATAACCA AGTGCATGAT GAAGACAGCC TAGAAAAACT CATTACGATC 360

TATTTTTTAC AAAACCGCAA AAAAGAGGGT TTGGTTCTGT TGCAATCTCA TATAGACAGG 420

TATGGTTGCT CAGAGCAATT GTGCCAAAAA GCGCTCAACA CCTTCACGCA ATTTAACGAG 480

CTTGATTTGG CTAAAACGAC TTTCGCTCGT TTGTATGAAA AAAACCCTAT TGTTCAAAAC 540

GCCCAATTTT ACATAGGGGT ATTAATCTTG TTAAAAGAGT TTGATAAGGC CCAGCAAATC 600

GCAGAATTAT TCCCCTTTGA CAGGCGTTTG TTGCTAGACT TATACACCGC GCAAAAAAAA 660

TTTGATCAAG CTTCCAAACA GGCTTCTTTA ATCTATCAAG AAAGAAAAGA CCCTAAATTC 720

TTAGGCTTAG AGGCGATTTA TCATTATGAA AGCTTGAGCG CGAATAAGAA AAAGCTCACC 780

AAAGAAGAGA TGTTGCCCAT CATTCAAAAA TTAGAGCAAG CCACCAAAGA GCGCCAAGCA 840

TGGCTTGCTA AAACTAAAGA TAAAGAAGAC GCGCAAGACG CTTTCTTTTA TAATTTTTTA 900

GGGTATTCCT TAATAGATTA TGACATGGAT GTTAAAAGGG GCATGGATCT TGTGAGGAAA 960

GCCTTAGCGT TAGATTCTAA CTCAGTGCTT TATTTGGATT CTTTAGCATG GGGTTATTAC 1020

AAATTAGGGA ATTGTTTGGA GGCTAAAAAA ATCTTTTCTA GCATCGCTAA AGAGCTTATC 1080

CAAAACGAAC CCGAATTGAA AGAACACAAT AAAATCATTC AAGAATGCAA GAAA 1134

(2) INFORMATION FOR SEQ ID NO: 14:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 468 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_£eature (3) LOCATION 1...468

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 14:

TTTTACACTG GCAAAAAGGG GGCTTGCATG CGTAAGATCT TGTTAATGGG CTTGATTTTA 60

CAAGCGCTCT TTGGCGAAGA AACCGCGCAA GAATTGTTGC AATGCTCTGC GATTTTTGAA 120

TCTAAAAAAG CCGAATTGAA AGAGGATTTG CGCCAATTGA GTGAAAAAGA GCAGTCTTTG 180

AGGATCTTGC AAACCGAAAA CGCCCGCCTT TTAGATGAAA AAAGCGATCT GTTAAACAAG 240

AAAGAAAAAG AAATAGACGA AAAACTGAAA AATTTAGCCG CTAAAGAAGA AGCCTTTAAA 300

ACCTTACAAA CAGAAGAAAA AAAACGCCTT AAAAATTTGA TAGAAGAAAA TGAAGGCATT 360

TTAAGAGAAA TCAAGCAGGC TAAAGACAGC AAGATTGGCG AGACTTATTC TAAAATGAAA 420

GATTCTAAAT CGGCTCTGAT TTTAGAAAAT TTACCCACTC AAAACGCT 468

(2) INFORMATION FOR SEQ ID NO: 15:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 423 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...423

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 15:

AAAAGGCTTT GTGATAGGCT TTGGAGCGGG GGATATTACC TATCAGTTGA GAGGCGAAAT 60

GTAATGGGCG TAGCGGTTGT TTTATTTTTA ACGCTAATTT TATTGTTTTT AGTTTTAAGG 120

GATTTTGGTT TAGCTAGCCC CAAACAAAAG ATTTTAGCTT TTTTAATCGT AGGGATTATA 180

GGAGCGAGCA TCAGCGTTTA TACTTATAAA CAAAACCAAC AAAACCAACA AGAAATCGCT 240

TTGCAAAGAG CGTTTTTAAG GGGGGAAACC TTGTTGTGTA AAGGCATCAA AGTCAATAAC 300

CAAACCTTTA ATTTAGTGAG CGGGACTTTG AGCTTTTTAG GCAAAAAACA AACCCCTATG 360

AAAGATGTTC TTGTGGATTT GGATTCTTGT CAGACGCTTC AAAAAGATCC CTTAATCCAA 420

CCT 423

(2) INFORMATION FOR SEQ ID NO: 16:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 303 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO ( iv ) ANT I - SENSE : NO

( vi ) ORIGINAL SOURCE :

( A ) ORGANI SM : He l i cobac ter pylori

( ix ) FEATURE :

(A) NAME/KEY: misc_ eature (3) LOCATION 1...303

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 16:

GCAAAAAATA CTATTTTTAA TAACGCTAAT TTTAACAACA GCACTTCTTT TAATTTCAAT 60

AATTCTAGCG CGACCACTTC GTTTGTGGGG GATTTCACTA ACGCTAATTC AAATTTGCAA 120

ATCGCTGGGA ACGCTGTTTT TGGGAACTCT ACTAATGGCT CTCAAAATAC CGCTAATTTT 180

AATAATACCG GCTCTGTTAA TATTGCAGGG AATGCAACCT TTGATAACGT GGTATTTAAC 240

AGCCCTACGA ACACAGGCGT GAAAGGGAAA GTTACTCTCA ATAACATCAC TTTAAAAACT 300

TGA 303

(2) INFORMATION FOR SEQ ID NO: 17:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 369 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...369

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 17:

TGGGCGATGA ATGTTTGGGT GTATAGGCCT TTGTTGGCTT TTATGGATAA CAGACAGGCA 60

GAGATAAAGG ACAGCTTGGC TAAAATCAAA ACGGATAACA CCCAAAGCGT GGAGATTGGC 120

CATCAAATTG AGACTCTTCT TAAAGAAGCC GCTGAAAAGC GCAGGGAAAT GCTAGCAGAA 180

GCGATTCAAA AAGCTACAGA GTCTTATGAC GCTGTGATCA AGCAAAAGGA GAACGAACTC 240

AATCAAGAGT TTGAAGCGTT CGCAAAGCAA TTACAAAATG AAAAACAAAT CTTAAAAGAG 300

CAATTGCAAG CGCAAATGAC GGTATTTGAA GACGAGTTAA ACAAGCGTGT GGCTATGGGT 360

TTAGGGAGT 369

(2) INFORMATION FOR SEQ ID NO: 18:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 309 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular (11) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...309

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 18:

AAGGGGGGAT TTATATCGGC AAAGAGTTGT TTAAGCATGG CTAGTGGCCT TTTTGAAAAC 60

GATGAAATCA AAAACAACAA AGCGCGAGAT TTTTTTTATA GCCATAGCTC CCTTATTGTC 120

TTTTTCCTCT TACTGCTTGG GTTTGGGTAT TATTTAGGGA AGTTGCTTTT TGGGGGTTCT 180

TCTTTAGAGG TCTATTTGGA TTTAAGAGAC AAGCATGAAC GATTGCAACA AGAAATCACC 240

GAATTGCAAA GCAAGAATGT GCGCTTGCAA AAGCGTTTGT TTGAGTTGAG GGAATTACGG 300

CCTAGAGAT 309

(2) INFORMATION FOR SEQ ID NO: 19:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 996 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...996

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 19:

TTATACTATA ATAGCCAATT AAATTGGGGT TTTACTGATT TGTCTTTGTG CGAGCTTTGG 60

CTTAGTTTTG TAAGGAATGA GATGATAAAG AGTTGGACTA AAAAGTGGTT TTTGATTTTA 120

TTTTTAATGG CAAGCTGTTT TGGTCATTTG GTGGCTACAA CCGGTGAGAA ATATTTTAAG 180

ATGGCTAATC AAGCCCTTAA GAGAGGGGAT TACCATAGAG CGGTGGCTTT TTATAAGAGG 240

AGCTGTAATT TGAGGATGGG GGTTGGTTGC ACGAGTTTAG GCTCTATGTA TGAATATGGC 300

GATGGCGTGG ATCAGAATAT TTCAAAAGCC GTTTTTTATT ACAGAAGAGG GTGTAATTTG 360

AGGAATTATC TCGCTTGCGC GAGTTTAGGC TCTATGTATG AAGATGGCGA TGGCGTGCAA 420

AAAGACTTTC CAAAGGCTAT CTATTATTAT AGGAGAGGGT GCCACTTAAA AGGTGGGGTG 480

AGCTGCGGTA GTTTGGGTTT TATGTATTTC AATGGTACGG GCGTTAAACA AAATTACGCC 540

AAAGCCCTTT CTTTTTCTAA ATACGCTTGC AGTTTGAATT ATGGCATTAG TTGTAACTTT 600

GTAGGGTATA TGTATAAGAG CGCCAAAGGC GTGGAGAAGG ATTTGAAAAA AGCCCTTGCG 660

AATTTTAAAA GAGGGTGCCA TTTAAAAGAC GGGGCGAGCT GTGTGAGCTT GGGATACTTG 720 TATGAAGCCG GTATGGATGT CAAACAAAAT GAAGAGCAGG CTTTGAATCT TTATAAAAAG 780

GGTTGCTCTT TAAAAGAAGG GAGCGGTTGT CATAATGTGG CGGTGATGTA TTACACGGGT 840

AAGGGAGCTC CAAAAGATTT GGAGAAAGCC ACTTCATATT ATAAGAAAGG GTGCGCTTTA 900

GGCTTTAGTG GTAGTTGTAA GGTGTTAGAA GTGATTGGCA AGGAGTCTGA TAATTTGCAA 960

GATGACGCGC AAAACGACAC GCAAGATAGC GTGCAA 996

(2) INFORMATION FOR SEQ ID NO: 20:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 282 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...282

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 20:

ATTAAGGTGA GGAGCGTCAA AAAGACTGAG CGAGGCTTAT TGATTGAGAA ATTCACTTCT 60

CAAGGCGAAT TAGTGCCTTT AGAAATTGTG GTAGAAACGA TCCTTTCAGA GATTAAAAGC 120

TCTAGTAAAG GGATCATTTT AATTGATGGC TATCCCAGGA GCGTGGAGCA AATGCAAGCT 180

TTGGATAAGG AATTGAACGC TCCAAATGAA GTGATTTTAA AAAGCGTGAT TGAAGTAGAA 240

GTGAGCGAAA ACACCGCTAA AGAAAGGGTT TTAGGGCAGT TT 282

(2) INFORMATION FOR SEQ ID NO: 21:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 339 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...339

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 21: CACTTTGTTT TTAGGGGCGA TTTTTGTTGG GCTTATCGCT ATTACTCCAT AGATAAGGAG 60

AGAGAGACTC AGAGGCATGA CAGCTCTTAC ATTGTGATAG ACGAATTAGT GGGCATGTGC 120

CTTGCGATGG CGATTAACGG ATTATCGTTA GTGGGTGTGA TCTTGAGTTT TATCTTTTTA 180

GGATGCTATG ATATTACTAA ACCCTCACTC ATTGGCAAAA TAGACAAAGA AGTTAAAGGG 240

GGCTTAGGGG TTGTGGCTGA TGACGCTTTA GCCGGGGTTT TAGCCGGATT GAGCACGTTA 300

TTAGCCATCA ATATTTTAGG ATTTTTTAAC ATTAAGTTT 339

(2) INFORMATION FOR SEQ ID NO: 22:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 237 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...237

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:22:

ATGTGGCCTG TGGCTCTCAA GCAGCCTAAT AGGGTGTCCC ATCATTTTTA TATCATGGCC 60

ATGCTTTTTA TTTTATTTGA TGTAGAAATC GTTTTCATGT TCCCTTGGGC GATTGATTTT 120

AAAAAGTTAG GCTTGTTTGG GCTCGTTGAA ATGCTAGGCT TTGTCTTCTT TTTGGCAATC 180

GGTTTTATTT ACGCTTTAAA GCGAAACGCT TTGAGCTGGC AAAAATTAGA GGTGAAA 237

(2) INFORMATION FOR SEQ ID NO: 23:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 180 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...180 (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 23:

TTTGATTTGG GCGTGCGCAC CAACTTTGCA AAAACCAATT TCAATAAGCA CAGATTAGAC 60 CAAGGGATAG AATTTGGGGT GAAAATCCCT GTTATCGCTC ATAAATATTT TGCAACCCAA 120 GGCTCAAGCG CGAGCTATAT GAGGAATTTT AGCTTCATAT GTGGGCTATT CAGTCGGTTT 180

(2) INFORMATION FOR SEQ ID NO: 24:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 444 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

( v) AN I-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...444

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 24:

TTTGGTTCAA GAGCTTTTAG AAGAATTTTT ACAAAGTGGG GCGAAAGAGA TTTTAGAAAA 60

GGCGCAGTTG TTTTAATGCG TTTATTGATC GCGCTAGTTT TGTTCTTATG GTGGTTAAAT 120

TTAGGCGCTA AAGAAGCGGA TTTCATCTCT GATTGGGAAT ACGGACTGGC CCTTTATAAA 180

AACCCTAGGG GTGTTGCGTG CGCCAAATGC CATGGCATTA AAGGCGAACA ACAAGAAATC 240

ACCTTTTATT ATGAAAAAGG CGAAAAAAAA ATCCTTTACG CCCCTAAAAT CAACCATTTG 300

GATTTTAAAA CCTTTAAAGA CGCCTTGAGT TTGGGTTTTT GTATGATGCC TACATACAAC 360

CTGAATTTAG AAGAAATCCA AGCGATTTAC CTTTACATCA CCTCTTTAGG GCATAAAGAC 420

GAGCGTAAGG ATCCTTCCAA GCCT 444

(2) INFORMATION FOR SEQ ID NO: 25:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 516 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI- SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature (3) LOCATION 1...516

(xi) SEQUENCE DESCRIPTION: SEQ ID NO : 25 :

AAAAATAGGC ATAAACTCTT ATACCTTCTA CTTAAAAACC TTAATTTTTT AAAAACCATT 60

TCCACAATTT TTACACAAAA GAGGGTTATC ATTCGTTCGC AACAAGGATT TTCTTGTTAT 120

CTTAATTTAA AGGTCAAAAC GATGAAAAAG TTAGCCGCTT TATTTTTAGT AAGCGCGTTG 180

GGGGTTATGA GTTTGAACGC ATGGGAGCAA ACCCTAAAAG CTAATGATTT GGAAGTGAAA 240

ATCAAATCCG TGGGCAACCC CATTAAAGGC GATAACACTT TTGTGCTTAG CCCCACTTTA 300

AAAGGTAAGG CTTTAGAAAA AGCTATCGTT AGGGTGCAGT TTATGATGCC TGAAATGCCC 360

GGCATGCCAG CGATGAAAGA AATGGCGCAA GTGAGTGAAA AAAACGGCCT TTATGAAGCT 420

AAAACCAATC TTTCCATGAA CGGGACATGG CAGGTTAGGG TGGATATTAA ATCCAAAGAA 480

GGCCAAGTTT ATCGCACTAA AACAAGCCTG GATTTA 516

(2) INFORMATION FOR SEQ ID NO: 26:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 222 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...222

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 26:

TGCTTATTTG TCCTTACAAA ATCTCAAAGG ATTAGAATGA AACGGCTTTT ATTGTTAGCC 60

TTGGCCCTCT TTTTTAGCCT CTCATGCACT AACGCTCAAG AAATTAAAGA AACTCAAGAG 120

ACTAAAAAAA CTAAAGAAAC TAAAAGCCAA ACCCGTTTTA ACATTTCCAC CACTAAGGTC 180

ATAGAAAAAG AATTTTCTCA AAGCCGGCGC TATTACGCGC TT 222

(2) INFORMATION FOR SEQ ID NO: 27:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 879 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: (A ) ORGANISM : Hel icobacter pylori

( ix ) FEATURE .

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1 .879

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 27:

ATAAAGTTTG CTAAAAAGAT AGTTTTAATT TTAAAAAAAG GTGGTTTTAT GAAAACAAAC 60

GGGCTTTTTA AAATGTGGGG GCTATTTTTA GTTTTAATCG CTTTAGTCTT TAACGCATGC 120

TCTGATAGCC ATAAAGAAAA GAAGGACGCT TTAGAAGTCA TTAAACAAAG GGGGGTTTTA 180

AAGGTGGGGG TTTTTAGCGA TAAGCCTCCT TTTGGCTCTG TGGATTCTAA AGGGAACTAT 240

CAAGGCTATG ATGTAGTCAT CGCTAAACGC ATGGCCCTTG ATTTATTGGG CGATGAAAAT 300

AAGATTGAGT TTATCCCTGT AGAAGCCTCA GCTAGGGTGG AATTTTTAAA AGCCAATAAA 360

GTGGATATTA TCATGGCTAA TTTCACGCGC ACTAAAGAAA GAGAAAAAGT CGTGGATTTC 420

GCTAATCCGT ATATGAAAGT CGCTTTGGGG GTGATTTCTA AAGATGGGGT CATTAAAAAT 480

ATAGAAGAGC TGAAAGATAA AGAGTTGATC GTGAATAAAG GCACGACAGC GGATTTTTAT 540

TTCACTAAAA ATTACCCCAA TATCAAACTT TTGAAATTTG AACAAAACAC AGAGACTTTT 600

TTAGCCCTTT TAAACAATAA GGCCATCGCA TTAGCCCATG ATAACACTTT GTTGCTCGCT 660

TGGGTGAAAC AACACCCTGA ATTTAAATTA GGCATTACAA GCCTTGGCGA TAAGGATGTG 720

ATCGCTCCAG CGATTAAAAA AGGCAACCCT AAGCTTTTAG AGTGGTTGAA TAACGAGATT 780

GATTCCCTCA TTTCTAGCGA CTTTTTAAAA GAAGCTTATC AAGAGACTTT AGAGCCTATT 840

TATGGCGATG GAATCAAACC GGAAGAAATT ATTTTTGAA 879

(2) INFORMATION FOR SEQ ID NO: 28:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2028 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...2028

(xi) SEQUENCE DESCRIPTION: SEQ ID NO : 28 :

GCTTTTGAAG AATTAGAGCC TTTGAGTTTT TCCTTCAATT CGCCTAAAGG GGCGTGCGAA 60

AGTTGTTTGG GTTTAGGGAC AAAATTTAGC TTAGATATTA GTAAGATTTT AGATCCTAAC 120

ACGCCTTTAA ATCAAGGAGC GATTAAAGTG ATTTTTGGGT ATAACCGCAG TTATTACGCT 180

CAAATGTTTG AAGGCTTTTG CACTTATAAT GGCATTGACA GCGCGCTTTG TTTCAACGAA 240

TTGAACAAAG AGCAGCAAGA CGCTCTTTTG TATGGGAATG GCACTGAAAT CAGCTTTCAT 300

TTTAAAAACA GCCCCTTGAA ACGCCCCTGG AAAGGCATTA TCCAAATCGC TTATGACATG 360

TTTAAAGAGC AAAAGGATTT GAGCGATTAC ATGAGCGAAA AAACCTGTTC TTCGTGTAAT 420

GGGCATCGCT TGAAAGCCTC AAGTTTGAGC GTCCAAGTCG CTGGCTTGAA AATGGCGGAT 480

TTTTTAACTA AGCCCATTGA AGAAGTCTAT CATTTTTTTA ATGATCCCAC GCATTTTAAC 540

TATCTTAACG AGCAAGAAAA AAAGATCGCT GAACCCATTT TAAAAGAGAT TTTAGAAAGG 600 GTGTTTTTTT TATACGATGT GGGGCTAGGG TATTTGACTT TGGGGAGGGA TGCGCGAACG 660

ATTAGCGGAG GGGAGAGCCA AAGGATACGA ATCGCCAGTC AAATCGGGAG CGGTTTGACA 720

GGGGTTTTGT ATGTTTTAGA CGAGCCTAGC ATTGGCTTGC ATGAAAAAGA CACGCTCAAA 780

CTCATCAACA CCCTTAGGAA TTTACAAAAA AAGGGGAACA CGCTCATTGT CGTAGAGCAT 840

GATAAAGAGA CGATTAAGCA TGCGGATTTT GTTGTGGATA TTGGGCCAAA GGCTGGAAGG 900

CATGGGGGTG AAGTGGTTTT TAGCGGGAGC GTAAAAGATT TATTGCAAAA TAACCATTCT 960

ACCGCCTTGT ATCTCAACGG CACTAAAAAG ATTGAGCGCC CCAAATTTGA ACCCCCTAAA 1020

GAAAAGCATT TTTTAGAAAT TAAAAATGTC AATATCAATA ACATTAAGAA TTTGAGCGTT 1080

CAAATCCCCT TAAAACAATT GGTGTGCATT ACGGGGGTGA GCGGGAGCGG TAAAAGCTCG 1140

CTGATTTTAC AAACCCTTTT ACCCACCGCT CAAACCCTTT TAAACCATGC TAAAAAAAAT 1200

CAAAGCTTGA ATGGGGTGGA GATTGTAGGG TTGGAGTATT TGGATAAAGT GATTTATTTA 1260

GATCAAGCCC CCATAGGCAA AACCCCACGA AGCAACCCCG CCACTTACAC GGGAGTGATG 1320

GATGAAATCA GGATTTTATT TGCCGAGCAA AAAGAAGCTA AAATTTTAGG CTATAGCACG 1380

AGCCGTTTCA GCTTTAATGT TAAAGGAGGG CGGTGTGAGA AATGCCAAGG CGATGGGGAT 1440

ATTAAAATAG AAATGCACTT TTTGCCTGAT GTGTTAGTCC AATGCGATAG CTGTAAGGGC 1500

GCTAAATACA ACCCCCAAAC TTTAGAAATC AAGGTGAAAG GCAAATCCAT TGCTGATGTG 1560

TTGAACATGA GCGTGGAAGA AGCTTATGAA TTTTTTGCTA AATTCCCTAA AATCGCTGTG 1620

AAGTTAAAAA CGCTTATAGA TGTGGGCTTA GGCTATATCA CTTTAGGGCA AAACGCTACG 1680

ACTTTAAGTG GGGGGGAGGC TCAAAGGATC AAATTGGCTA AAGAATTGAG TAAAAAAGAC 1740

ACAGGCAAAA CCCTTTATAT TTTAGATGAG CCTACCACCG GTTTGCATTT TGAAGATGTG 1800

AATCACCTTT TACAAGTCTT GCATTCTTTG GTGGCGTTAG GCAATTCCAT GCTAGTGATT 1860

GAGCATAATT TAGACATCAT CAAAAACGCT GACTACATTA TAGACATGGG GCCTGATGGG 1920

GGGGATAAGG GCGGGAAAGT CATTGCGAGC GGCACGCCTT TAGAAGTGGC GCAAAATTGC 1980

GAAAAAACCC AAAGCTATAC GGGAAAATTT TTAGCTTTGG AATTGAAA 2028

(2) INFORMATION FOR SEQ ID NO: 29:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 414 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...414

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:29:

ATTATTATTG ACTATTCAAG CCAGTATTTT AGCGGGAGGG CTGCGGCGTT CTATCAAGCT 60

TTGGATAATT TCATCTCACG ATACGCGCAA CGCTTGATCG TAACCAATTT GAGTCAAGCG 120

ATTCGCATTT ATGGCTATGA AGTGGGTGGG ACTTTTAGAT ACAAGGGCGT GAGTTTGAAT 180

GTGGGGATCT CGCGCACTTG GCCCACCACT AGGGGGTATT TAATGGCGGA CAGCTATGAG 240

CTTGCCGCAA GCACCGGTAA TGTTTTTATC ATTAAATTGG ATTACACCAT TTCCAAAAAC 300

AGGGATCAAT CTTGCATGGC TTTAGCCGCT TTGTTACCGG TTTGGATTAT TGCGGGTTTG 360

ATATTTACTT GCCTGATTAT GGGACAGCTG AAAAACCCAA AACCCCTACC GATT 414

(2) INFORMATION FOR SEQ ID NO: 30: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 519 base pairs (3) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI- SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...519

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 30:

CAAGGAATGG GCTTGAAAAA TCTCTCAACA CTTCTGGTGT TTTTATTCTT TTGTTTGGGG 60

TGTGTGAGCA ATTTTAATGA AGACACTTAC ACGCTAGACT TAGTTTTAGA AAAAAAGATC 120

CAAGCCAGTA GGAAAGGCGA AATCACCCAA GATAATGTGC CTATCATCAC GGCTATCGCT 180

ACGCATTTAA ACGATGTGGA TAGCGGCACT TACTACGATC ATGAGTATTT TTTAGTGGAG 240

ATTTTCACGC AAAATAACGA CTGGATAGAT GATGGCTATA TTTCTTATGA ACTTTTTGGC 300

ACAAAACCTA CAGGATCAGA ACCTTTATGG GTGCGAGAGA TTACAAGAGA TGAATTTGAT 360

GGCATTTTAG AAACCACGAA CCGGTGGAGC CGAGCCTTTT TGATCGCTTT TGACAAATTG 420

GATTATTTAG CGGTGCAAGA AGCCAAACTA GAGCTTGATG CCTATAGTTT AGGCAAAATT 480

GTTTTTAATT TCGCTTACCA AGTCCCCTTA CCTCAATTT 519

(2) INFORMATION FOR SEQ ID NO: 31:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 327 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...327

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 31:

CAAAAAGAAG TATCTAACTA TGAGGAATCC ATTTTAGTCA ACACTCCTTA TGCAAGGGTT 60 AATATTCTCG CGATTGAAAA AAATGAAAGT CCTATTGAAT TACTGGCTCC GGTAGATTTA 120 GTTACCGCTT TGAGCGATTT GATGCTAGGA GGTGAGGGGG CGAGCAAGGA AGAAATGGAT 180

AATGACGATT TAGACGCTTT TAAAGAAATG GCTTCTAATA TTTTTGGTGC GATCGCTACA 240

AGCTTGAAGT CTCAAGAATT GCTCCCTAAA CTCAATTTCA CCACCACGAA CGCTGAAATC 300

GCTAAAGAGC TTCCTAAAAA AGAAGAT 327

(2) INFORMATION FOR SEQ ID NO: 32:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 546 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...546

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 32:

ATTTGTTTAT TAAAGGAAAA AATCATGTCA AATAGCATGT TGGATAAAAA TAAAGCGATT 60

CTTACAGGGG GTGGGGCTTT ATTGTTAGGG CTAATCGTGC TTTTTTATTT GGCTTATCGC 120

CCTAAGGCTG AAGTGTTGCA AGGGTTTTTA GAGGCTAGGG AATACAGCGT GAGCTCTAAA 180

GTCCCTGGCC GCATTGAAAA GGTGTTTGTT AAAAAAGGCG ATCGCATTAA AAAGGGCGAT 240

TTAGTTTTTA GCATTTCTAG CCCTGAATTA GAAGCCAAGC TCGCTCAAGC TGAAGCCGGG 300

CATAAAGCCG CTAAAGCCGT TAGCGATGAA GTGAAAAGAG GCTCAAGAGA TGAAACGATC 360

AATTCTGCGA GGGACGTTTG GCAAGCGGCA AAATCCCAAG CGAATTTGGC TAAAGAGACT 420

TATAAGCGCG TTCAAGATTT GTATGACAAT GGCGTGGCGA GTTTGCAAAA GCGCGATGAA 480

GCCTATGCGG CTATGAAAGC ACCAAATACA ACGAGAGCGC GGCTTACCAA AAGTATAAAA 540

TGGCTT 546

(2) INFORMATION FOR SEQ ID NO: 33:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 444 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE. DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE: (A) NAME/KEY: misc_feature (3) LOCATION 1...444

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 33:

ATGGAATTTT TGAGCGGGTA TTTTTTATGG GTTAAAGCTT TCCATGTGAT AGCGGTCATT 60

TCGTGGATGG CAGCGTTATT TTATTTGCCA CGCCTTTTTG TCTATCATGC AGAGAACGCG 120

CATAAAAAAG AGTTTGTAGG CGTGGTTCAA ATCCAAGAGA AAAAGCTCTA TTCCTTTATC 180

GCTTCGCCGG CGATGGGTTT CACGCTTATT ACAGGGATTT TGATGTTGTT GATCGCCCCT 240

GAAATGTTTA AAAGCGGGGG TTGGTTGCAT GCTAAATTGG CTTTAGTGGT ATTGCTTTTA 300

ATCTATCATT TTTATTGCAA AAAATGCATG CGCGAGCTGG AAAAAGACCC TACAGGGAAA 360

AACGCAAGGT TTTATCGTGT GTTTAATGAA ATACCCACGA TTTTAATGAT CCTTATTGTG 420

ATCTTAGTGG TTGTCAAGCC TTTT 444

(2) INFORMATION FOR SEQ ID NO: 34:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 873 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...873

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 34:

GGATTAACCA TTAGACAGGC GTTTAACAAA ACAAGATCCA CGCATTCAAG AACCCTTTTA 60

CTAGACATTG ATTGCGTTAT CCCTAATATT GTTAGGCGTT TGCTCTCTAA TAAAACGCTC 120

CCTAAAAGAT TCGCCACTTA TAGCTTGCAA GAAGTGGGCG TTATTTTCCT GACCACTCAG 180

ATTTTATCTA TCATGCGCAA GACCCGTTGC TCTAAAACGC TTTTTTTTAT CACTAGGGGC 240

AGGGAGAGTT TCCGCTACCA GCTGTGCGAT CATTACAAAC AAAAACGCCA CCAATTTGAT 300

GAAGATTTTA GATCCCTTTT AAAAGCTCTC AAAATCGCTT TAGTGGAAAA ATACCCCCTA 360

AAAAAAGGGG CTAAAATCCA GGGCGAACAT TGTTTTGAAT ATGAAGCCGA TGATATTATC 420

TCTTTTTACA AAAAGAAAGA CCCCAACAAT TATGTGATAG CGAGCATGGA TAAGGATATT 480

TTGTATTCCA ATAGAGGCTC TCATTTCAAT CTCAAAACGA ACGCTTTTTT TAATGTGAGC 540

CAAAAAGAAG CCCATTTTTT TGCTTATTAC CAATGCGTTG TGGGGGATAA AGGGGATAAT 600

ATTAAGGGGG TTAAAGGGAT TGGCGGCTTC AACTATAAAG ATTTTTTAAA CGAAGACGCT 660

AAAGAGCATG AACTATGGGA GCAGATCATT CAAGCGTTCA AAATTAAAGA AGATTTGAGC 720

GATAGCGAAG CCAAAGAAAA GGCTCTATTA AACATGCGTT TAGTCAATAT GCACCAGATG 780

ACCCACCATG GCGTGATCAA ACTATGGGAG CCTGAGTTTA AAAAAGCTTT TTTCCCTAAA 840

AAACCCCAAA GACCTGATTT TAAAAGAATT TCT 873

(2) INFORMATION FOR SEQ ID NO: 35:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 579 base pairs (B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...579

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 35:

GGCGTTTATC ATAATAAGGA AATCATTGTC GCTTATAGGA AGATTGGCAA GGTGCATTCC 60

ACTTTAACCA CAACAAGCAT GATTTTAGCG TTTGGCGTTC AGAAGGTGCT TTTTAGCGGG 120

GTGGCTGGAA GCTTAGTTAA AGATTTAAAA ATCAATGATT TGTTAGTGGC TACTCAATTA 180

GTCCAGCACG ATGTGGATTT GAGCGCGTTT GATCACCCTT TAGGGTTTAT CCCCGAAAGC 240

GCGATTTTTA TTGAAACGAG TGGAAGTTTA AACGCTTTAG CTAAAAAGAT CGCTAATGAG 300

CAACATATCG CGCTCAAAGA AGGCGTCATC GCATCAGGCG ATCAGTTTGT GCATAGCAAA 360

GAAAGGAAAG AATTTTTAGT TAGCGAGTTT AAAGCGAGCG CGGTGGAAAT GGAGGGGGCG 420

AGCGTGGCGT TTGTGTGCCA AAAATTTGGC GTGCCATGCT GCGTGCTAAG GAGCATTAGC 480

GATAACGCCG ATGAAAAAGC CGGTATGAGT TTTGATGAAT TTTTAGAAAA AAGCGCTCAC 540

ACTTCAGCGA AATTCTTAAA AAGCATGGTG GATGAGCTT 579

(2) INFORMATION FOR SEQ ID NO: 36:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 240 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...240

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 36:

AAACTCGCCC TTTTCAAACA ACGCCAACTC AAACAAAATA AAAACGCTCA AGCTAATCCT 60

AAAAGCCCTT TCATCACCCA TGTGGTCTTG CCTAAAGAAA CCTTATCTTC TATCGCTAAA 120

CGCTATCAAG TCAGCATTTC CAGTATCCAA TTAGCCAATA ACCTCAAAGA TTCTAATATC 180

TTTATCCACC AGCGCTTAAT CATCCCCACT AACAAAAAAT TACTCGCTAC AAGGGAATTT 240 (2) INFORMATION FOR SEQ ID NO.37

(l) SEQUENCE CHARACTERISTICS-

(A) LENGTH 735 base pairs (3) TYPE- nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE. NO

(v ) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...735

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 37:

GGTCATAGAA AAAGAATTTT CTCAAAGCCG GCGCTATTAC GCGCTTTAGA GCCTAATGAA 60

GCGCTGATTT TTTCTCAAAC CCTGCGTTTT GATGGCTATG TGGAAAAGCT TTATGCGAAT 120

AAAACCTATA CCCCCATTAA AAAGGGCGAT AGGCTATTGA GCGTGTATTC CCCTGAATTA 180

GCGGGCGTTC AAAGCGAGCT GTTATCGTCA TTGAAATTCA ACCAGCAAGT GGGAGCGATT 240

AAAGAAAAAT TAAAACTACT AGGGCTAGAA AACTTTAGCA TTGAAAAAAT CATCAGCAGC 300

CATAAAGTCC AAAATGAAAT CACTATTTAC TCTCGTTTCA ACGGCGTTAT TTTTAAAAAA 360

AGCCCGGATC TCAATGAGGG GAGTTTCATT AAAAAAGGGC AAGAGCTTTT CAAAATCATA 420

GATTTAAGCC GATTGTGGGC GCTTGTTAAA GTCAATCAAG AGGATTTAGA ATTTTTAAAA 480

AACACGCATC AAGCGATTTT GTTCGTAGAG GGGGTTAAAG GCAAGCAAGC AATCACGCTT 540

GAAAACATCA ACCCCATCAT AAATGCGCAA GATAAAATGC TAGAAGCGCG CTTCAATGTG 600

CCTAATCTTA AATTGCTTTA TTACCCTAAC ATGTTCGCTC AAGTAGAAAT CTTTCACAAA 660

CCCCAAAAAA TGAAGATCTT GCCTAAAGAA GCGGTTTTGA TTAAGGGGGG GAAAGCTATC 720

GTGTTTAAAA AAGAT 735

(2) INFORMATION FOR SEQ ID NO : 38 :

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 456 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature (B) LOCATION 1 .456

(x ) SEQUENCE DESCRIPTION- SEQ ID NO .38

AGTGGAGAAC ACACAATGAA AAAATATATC TTAAATTTAG CGTTAGTGGG CGCGTTGAGC 60

GCGTCGTTTT TGATGGCTAA GCCGGCTCAT AATGCGAATA ACTCTACGCA TAACACGAAA 120

GAAACGACTG ATGCTTCAGC AGGCGTGTTA GCGACAGTGG ATGGCAGACC CATCACCAAA 180

AGCGATTTTG ATATGATTAA GCAACGAAAT CCTAATTTTG ATTTTGACAA GCTTAAAGAG 240

AAAGAAAAAG AAGCCTTGAT TGAGCAAGCT ATCCGCACCG CGCTTGTAGA AAATGAGGCT 300

AAGGCAGAAA AGCTTAATCA GACTCCAGAA TTTAAAGCGA TGATGGAAGC GGTTAAAAAA 360

CAGGCTTTAG TGGAATTTTG GGCTAAAAAA CAGGCTGAAG AAGTGAAAAA AGATCCAAAT 420

CCCAGAAAAA GAAATGCAGG ATTTTTACAA CGCCAA 456

(2) INFORMATION FOR SEQ ID NO: 39:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 552 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...552

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 39:

AGAGCCTTAA AAACGCATGG CGCTCTTGCC TTTGTTCAAG CTTTTTTGGA GTCTTTTAAG 60

GGATTTTTAA GCCAAGCGAC CTTAATTAGC GTTTTAATAG CGAGCGTTTT AATCCTTTTT 120

TGCGCGATTT TGCTCCTTTT GGCTCTGCTT TTAAGAAACC GCTGGGCTAG TTATATAACA 180

ACAGCAGCTT TTTTGGGCGC GTTTTTAAGC ATGCCTTTTG TTTTGAACGT TTTACTCACT 240

CAAGCGATTT ACCCCATAGA AACGCGCATC TTGCACGCTA ATCCCTTAAG TTATAGCAAC 300

GCCTTTTCTT TGCAAGTGGG AGTCAAAAAC ATTTCCAAAT TCAGTCTAAA CAAATGCGTT 360

TTACGTCTAG AAGTCCTTAA AAACCCTCAC AATTTTGTGG AAGAGCGAGC TTTTAAATGG 420

TTTGTCAAAA AAAGCTATGA AAAAACCTTT AAAGAAAAGA TTTTGCCTGA AGAATCCAAG 480

GTCTTTTCAT TCTTTATTGA CGACTACCCT TATTCAAAAA CGGCCCCTTA TCAAGTTTCT 540

TTGTTTTGTT TG 552

(2) INFORMATION FOR SEQ ID NO: 40:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 345 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...345

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 40:

GCCATGAATA TCAAAACCCA TTCTTCAAAT GAAAAAGAAC GCTTTGTACG CATAGAAGAG 60

GACGAAAAGA AAGAATTATT CGCCGAAGCT ACAAATGAAA ATCCGCACGG CCTTTCTTTA 120

ATGGCTTTAA TAGGGGTGTT GGTTTTTGGG GGTGCGTTTT TAGCCTTATT AGTGCCTAAA 180

ATCTATTTAA GCAATAATAT CTATTATATT AGCCGTAAAA TTAATACCCT AGAAGATCAA 240

AAACGCCTGC TTTTAGAAGA ACAGCAAATC CTAAAAAACG AATTAGAAAA AGAGCGTTTT 300

AAATACTACA TAGAGAATAG TGAAAATATT GGCGATATTG CGTTT 345

(2) INFORMATION FOR SEQ ID NO: 41:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 714 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...714

(x^'l) SEQUENCE DESCRIPTION: SEQ ID NO: 41:

CTCCTTTTAA TCCACTTTCT TATTTTAAGG AAACTCTTGC AACATAAAAC CATTATGGAT 60

AAGATCATTA TTCAAGGGGC TAGGGAAAAC AATCTCAAAA ATATCTTTTT AGAAATCCCT 120

AAAAACCAAT TTGTTGTTTT TACCGGATTA AGCGGTTCGG GTAAATCCAC TCTGGCGTTT 180

GACACTCTAT ACGCTGAAGG GCAAAGGCGC TATTTAGAGA GTTTGTCTAG TTATGCGAGG 240

CAATTTTTAG ACAAAGTGGG TAAGCCTAAT GTGGATAAAA TTGAAGGCCT AACCCCAGCG 300

ATCGCTATTG ATCAAAAAAC CACTTCTAAA AACCCTAGAT CCACTGTGGG GACGATCACT 360

GAGATTTATG ATTATTTAAG GTTGTTGCTT GCAAGGGTTG GGGAGCAATT TTGCCCCACA 420

TGTTTAGAGC CTATTAGTTC TATGAGCGCG AGCGATATCA TTTCTCAAAT CTGTCATTTA 480

GAAGAAAATT CTAAAATCAT TATTCTAGCC CCCATTATTA AAGATAAAAA AGGTTCGTTT 540

AACGATAAAT TAGAGAGTTT GCGTTTGAAG GGGTATGTGA GGGCTTTTGT TGATGGGGTG 600

ATGGTGCGTT TAGATGAAGA AATCCATTTG CACAAAACCA AAAAACACAC CATTGAAGCG 660

GTGGTGGATA GGGTGGTTAT CAATAGCGAA AATGCTTCAC GGATCGCTAG CGCG 714

(2) INFORMATION FOR SEQ ID NO: 42: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1083 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...1083

(Xl ) SEQUENCE DESCRIPTION: SEQ ID NO: 42:

CACCAATCTT TTAAAAGAGC GTTTGAACCA AGAAGAAAAG GGCGAGTTTT TAGAATAATG 60

GGTTTTGAAA AAAGCATTTT AGACAATTTG AACGGAGCGC AAAAAATTGC CGCATGCCAC 120

ATTCAAGGGC CTTTATTGAT TTTAGCGGGA GCTGGGAGCG GTAAGACTAA GACTTTAACG 180

AGCCGTTTAG CGTATTTGAT TGGCGCTTGT GGCGTGCCTA GCGAAAACAC TTTAACGCTC 240

ACTTTCACCA ATAAAGCGAG TAAAGAAATG CAAGAAAGGG CTTTGAAATT GTTGAAAAAC 300

CAAGCCCTTA TCCCCCCCTT GCTTTGCACT TTCCATCGTT TTGGTTTGCT GTTTTTAAGG 360

CAACACATGA ATCTTTTAAA AAGGGCGTGC GATTTTTCGG TGCTAGATAG CGATGAAGTG 420

AAAACGCTCT GCAAACAGCT CAAAATTTCA AATTTCAGGG CGAGCATTTC TCAAATCAAA 480

AACGGCATGA TGGATTTGAG CGTGCAAGAT AGCGAATGTT ACAAAGCGTA TGAGCTTTAT 540

CAAAACGCGC TCAAAAAAGA CAATTTAGTG GATTTTGACG ATTTGCTTTG TTTGAGCCTT 600

AAGATTTTAC AAGATAATGA AAAACTCGCC AAAGAGACCA GCGAACGCTA CCATTACATT 660

ATGGTAGATG AGTATCAAGA CACGAACGCC CTGCAACTGG AATTTTTAAA ACAATTGAGT 720

TTCACGCACC ATAATTTGTG CGTGGTGGGC GATGACGATC AGAGCATTTA TGGGTTTAGG 780

GGGGCTGATA TTTCTAACAT TTTAAATTTT TCCAAGCATT TTAAAGGGGC TAAAATAGTG 840

AAATTAGAGA CCAACTACCG CTCTAGCGCT GAAATCTTAG CGTGCGCTAA TTCCCTGATC 900

AGCCATAACC AACACCGCCA CATTAAAACG CTTCAAAGTT TCAAAGGTTC GCACAAAAGC 960

GTGATTTGTA AAGAATACCC CACGCAAAAA GAAGAGAGCC TGGATGTGGC TTATCAGATT 1020

CAAAGCCCTT TTAAAGAAGG GCGAGAATTT AGAAAATATC GCTATTTTGT ATCGTTTAAA 1080

TGG 1083

(2) INFORMATION FOR SEQ ID NO: 43:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 456 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi ) ORIGINAL SOURCE: (A ) ORGANISM : Hel icobac ter pylori

( ix ) FEATURE :

(A) NAME/KEY: misc_feature

(B) LOCATION 1...456

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:43:

ATGAGAAAAA CGATTTCAGC GTTGTTTTTA TCAGCGTGTA TAGGGTTATC GTCTGTTCAT 60

GCGAGTAACG CTTTGATTTT ACAAACAGAT TTTAGCCTAA AAGATGGGGC CGTCTCGGCG 120

ATGAAAGGCG TCGCTTTCAG CGTTGATTCT AATCTTAAAA TCTTTGATTT AACGCACGAA 180

ATCCCCCCGT ATAACATTTG GGAAGGCGCT TACCGCTTGT ATCAGACCGC TAGTTATTGG 240

CCAAAAGGCT CGGTATTTGT GAGCGTAGTG GATCCGGGCG TAGGCACTAA TCGTAAATCG 300

GTGGTATTGA AAACTAAAAA CGGCCAGTAT TTCGTCTCTC CAGATAACGG CACGCTGACT 360

TTGGTAGCGC AAACTTTGGG GATTGATAGC CGAGCTGAAA TTGATGAAAA TTCCATCCGT 420

CTGAAAGGTT CGAAATTCCT GTCTTCCCGT CCGGTG 456

(2) INFORMATION FOR SEQ ID NO: 44:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 729 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...729

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 44:

GACATCTTTA ATAAGGAAGA GATCATGGCC ATTGATTTAG CAGAAGTTAC AGGAGCTAAA 60

GCCGCGCAAG AAAGGAAAAA AGAACAGCCC ACCATCGCTA ACGGGTTGGA TAAAAACGCT 120

TTCATGAAAC TCTTTTTAGA GCAATTGAAA AATCAAGACC CCACCGCTCC TATGGAAACG 180

GATAAAATCA TCACCCAAAC CGCGCAACTC ACGCAAGTGG AAATGCAAGA AGAAAACAAA 240

AAGACCATGC AAGAAGTCGC CAGTGCGATG AAATCCAATA AAGAAACTAA CGAATCTTTA 300

AAAGACTTTC AAGGCGCTTT AAAAGACACC ATGGAAAACC TGAACAAAGG CATGGACGAT 360

AGCTTAAAGG CTAACAACGC TTTAAGGGAA GTAAGCGCCC TTAATTCTGT GAGCATGATA 420

GGCAAAATCG CTGAAACCGA TGTGAGTGGG GCGAATTTTG ACGGCAACAA CAAGCTTTCT 480

TTTTCGCTCT TTTTTGATGA AAAAATTGAC GCTTCTAAAG GAGTGCCAGC GATTCAAATC 540

TTAAACGAAA ACAATGAATT GGTCAAAACG ATTCCTTTAA AAGATTATAA CGGGCAAAAG 600

GGGTATATCA ATTTTGAATG GGACGGCACA AACGAAAAGG GCGAAAAAGT TCCTAAAGGC 660

AATTACAAAA TCAAGGCTGA ATACAATTTA GGCTCTCCAA AGCAAGCTGT ATTTGCAAAC 720

GCGCATTGG 729

(2) INFORMATION FOR SEQ ID NO: 45:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 759 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...759

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 45:

AACGCTCATG CCTTTACCCA TCCATTTAGC GCACCAGCTC GCTTTCGCCT AGCTCAAAAA 60

AGAAAAGACA ACACCTTGCC TTTTTTAAGG CCTGATGGCA AGTCTCAAGT GAGCGTGCGT 120

TATGAAAACA ACAAGCCTGT AAGCGTTGAT ACGATTGTCA TTTCCACCCA ACATTCCCCA 180

GAAGTTTCAC AAAAGCATTT AAAAGAAGCG GTGATTGAAG AGATCGTGTA TAAGGTTTTA 240

CCCAAAGAAT ATTTGCATGA CAATATCAAG TTTTTTATAA ACCCTACAGG AAAATTCGTC 300

ATCGGTGGGC CTCAAGGCGA TGCGGGTTTG ACAGGTAGAA AAATCATCTG GGATACTTAT 360

GGAGGGTTTT GCCCGCATGG AGGGGGAGCG TTTACCGGGA AAGACCCTTA CAAGGTGGAT 420

ATGAGCGCGG CTTATGCGGC CCGCTATGTG GCTAAAAATT TGGTAGCGAG CGGGGTTTGC 480

GATAAAGCGA CCGTGCAGCT TGCTTATGCG ATTGGGGTGA TAGAGCCTGT GTCTATTTAT 540

GTGAACACGC ATAACACGAG CAAGCATTCA AGCGCGGAGT TGGAAAAATG CGTGAAATCG 600

GTTTTCAAAC TCACGCCAAA AGGCATCATT GAAAGCTTGG ATTTGTTAAG ACCCATTTAT 660

TCGCTCACTT CAGCTTATGG GCATTTTGGG CGCGAGTTAG AAGAATTCAC TTGGGAAAAG 720

ACTAACAAGG TTGAAGAGAT TAAAGCGTTC TTTAAGCGT 759

(2) INFORMATION FOR SEQ ID NO: 46:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 195 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...195

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 46: GTTATTAGTT ACCATTTTAT TATTCTTAAG GATGTGTTTA TAATGAGAAT TAAGGCTTAT 60

TTTTTGCGTT TATCGCACTG GTTTTTATCG TTTGGTTGGG TTTTAGCGCT TGTAAAAACT 120

CTCAAAAATC TCAAGATTCT CAAAACAATA CCACCCAACA AGATAGCCCT AAAACCTACA 180

CCGTATGGAT CTGAA 195

(2) INFORMATION FOR SEQ ID NO: 47-

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH. 366 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...366

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 47:

AAAGGAATAA GCATGAAAAA ATCCCTTTGT TTGTCTTTCT TTCTGACCTT CTCTAACCCT 60

CTTCAAGCCC TTGTCATTGA GCTTTTAGAA GAGATTAAAA CTTCGCCGCA TAAAGGCACT 120

TTTAAGGCTA AAGTCCTTGA TTCTAAAGAA CCAAGACAAG TTTTAGGCGT TTATAATATC 180

TCCCCACACA AAAAACTCAC GCTCACTATC ACTCACATAT CCACGGCAAT CGTCTATCAA 240

CCCCTTGATG AAAAACTTTC TTTAGAAACG ACCTTAAGCC CTAACCGCCC TACTATCCCT 300

AGAAACACCC AAATCGTTTT TTCTTCAAAA GAATTGAAAG AACCGCACTC AAACCCAATA 360

CCTTCT 366

(2) INFORMATION FOR SEQ ID NO: 48:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 408 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...408 (xi) SEQUENCE DESCRIPTION SEQ ID NO 48

AAAAAATTTC ACACTTTAAT ACTTCCTGTT GAGTGGGGAA CTGAGATTGT CTTGGTGGTT 60 GTGGCTCGT TGCAAAACAT TGTTCGTTCT TTTTTGCGAA GGATCAGCGT TTTCTTCATT 120

ATTGATTTCA TCAATTTTAT TTTCGTTATT GATCAGATCA TTCACTTCTT TGGTGACTTT 180

TTCATCTTCT TCTTCATGC CAATCTTTTT TATATCCTTA TTAGGTTGAT TGATTTGATT 240

GTTTTGAGTG GTTTTAGTGT TGTTTTGGTG CGATTGGGAC AATTTTTTAG GCTCATCTTT 300

GCGTGCGCTC AACACGCTTT TAACAAGGTA GATATCGATA AAATGAGTGA TTTTAGATTT 360

CATCAATTAA GTTTCTTTAA ATCAGTGTAT AATTTGTTTA TTTTATCA 408

(2) INFORMATION FOR SEQ ID NO: 49:

(l) SEQUENCE CHARACTERISTICS-

(A) LENGTH. 207 base pairs

(B) TYPE nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...207

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 49:

TACTTCCTGT TGAGTGGGGA ACTGAGATTG TCTTGGTGGT TAGTGGCTCG TTGCAAAACA 60

TTGTTCGTTC TTTTTTGCGA AGGATCAGCG TTTTCTTCAT TATTGATTTC ATCAATTTTA 120

TTTTCGTTAT TGATCAGATC ATTCACTTCT TTGGTGACTT TTTCATCTTC TTCTTCATGC 180

TCAATCTTTT TTATATCCTT ATTAGGT 207

(2) INFORMATION FOR SEQ ID NO: 50:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH. 729 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY- mιsc_feature (B) LOCATION 1...729

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 50:

ACTCTTTTTA AGTCAAGCGA TAAAGTTTGC AACCTAATGA GAGTAATAAT AAAGTTTATG 60

CTGATTTCAT TAAAAACATT CCTAAAAATA TTATTGGAAA TATTCCTAAA AACCTTCCAA 120

AAGATTTGGA TAGTTTGCGT GGTTATTTGG GGGTTGGGCT GTAGTTTTTT AAACGCTAAC 180

AGCGTTCAAT TAGAAGAAAC GCTGAGACGA AATCCTAAAA ATCTTATTTG GCAACACTTT 240

AAAAAGAAGT TTAAAAAGAG TAACACGATC CCTTATGCCC CTAATAGCCG TTGGAAATAT 300

TTAGGCACAA GTATAGGGAT TTTGGGCGTG TCGTTGGTGA TAGGGATTGT GGGGTTGTAT 360

CTCATGCCAG AGAGCGTAAC GAATTGGGAT AAAGAAAAGT TTGGCGTCAA AAGTTGGTTT 420

GAAAATGTCC GCATGGGGCC AAAACTAGAC AATGATAGTT TTATTTTTAA TGAAATCTTG 480

CACCCTTATT TTGGGGCTAT GTATTACATG CAACCGCGCA TGGCTGGGTT TAGCTGGATG 540

ACATCAGCGT TTTTTTCTTT TATCACTTCT ACACTTTTTT GGGAATATGG CTTGGAACCG 600

TTTGTGGAAG TGCCTAGCTG GCAGGATTTG GTGATCACGC CCTTACTAGG TTTCATTTTA 660

GGGGAAGGGT TTTACCAGCT CACGCCTATA TCCAACGCAA CGAAGGCAAG CTGTTTGGCT 720

CTTTATTTT 729

(2) INFORMATION FOR SEQ ID NO: 51:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1458 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1458

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 51:

AAAAAAAGGA AACCAATGTT TAGAAAACTA GCAACCTCTG TATCGCTCAT AAGCCTACTA 60

ATCTCCAACG CTCTTTATGC TAAAGAAATA AGTGAAGCCG ATAAGGTCAT TAAGGCCACT 120

AAAGAAACTA AAGAGACCAA GAAAGAGGCT AAACGCCTCA AAAAAGAAGC TAAACAGCGC 180

CAACAGATCC CTGATAATAA GAAACCTCAA TATGTCTCTG TTGATGACAC AAAAACTCAA 240

GCGCTTTTTG ATATATATGA CACTTTGAAT GTGAATGACA AAAGCTTTGG GGATTGGTTT 300

GGTAATAGCG CTTTGAAAAA CAAAACTTAT CTCTACGCTA TGGATCTATT GGATTATAAC 360

AACTACTTAT CCATAGAAAA CCCTATTATC AAAACAAGAG CGATGGGAAC TTATGCAGAT 420

CTGATTATCA TCACAGGTTC GTTAGAACAA GTCAATGGGT ATTACAATAT TCTAAAAGCG 480

CTCAACAAAC GCAACGCTAA GTTTGTGTTA AAAATCAATG ACAAAATACC TTATGCCCAA 540

GCGACTTTTT TGAGAGTGCC AAAAAGAAGC GATCCCAACG CCCACACGCT TGATAAGGGA 600

GCGTCAATTG ATGAAAGCAA GCTTTTTGAA CAACAAAAGA AAATGTATTT CAACTACGCC 660

AACGATGTGA TCTGCAGACC CAACGATGAA GTGTGTTCGC CCCTAAGAGA TGAAATGGTA 720

GCTATGCCCA CTAACGATAG CGTTACTCAA AAACCCAATA TCATTGCTCC TTATAGCCTG 780

TATAGACTAA AAGAGACAAA TAACGCCAAT GAAGCCCAAC CATCACCTTA TGCCACTCAA 840

ACCGCTCCTG AAAACAGCAA AGAGAAGCTC ATAGAAGAGC TAATCGCCAA CTCCCAACTC 900

ATAGCCAATG AAGAAGAGAG GGAAAAGAAA CTCTTAGCAG AAAAAGAAAA ACAAGAGACT 960 GAATTGGCTA AATACAAGCT CAAAGATTTA GAAAATCAAA AGAAACTAAA AGCTTTAGAA 1020

GCAGAGTTGA AAAAGAAAAA CACTAAGAAA CCTAGAGTAG TGGAAGTGCC TATTCCTCCT 1080

AAAACAAGTG ATTCTGATGA AACAATGAGA GTTATCAAAG AAAAAGAAAA CTATAATGGG 1140

TTATTAGTGG ATAAAGAGAC CACGATCAAA AGAAGCTATA AGGGGACTTT GATCAGTGAA 1200

AATTCTTACA GCAAAAAAAC ACCCATCAAC CTTGAGGACT TGAGAAGCTT AGAAGAAGAA 1260

ATTAAGAGCT ACTATGTCAA GTCTAATGGC TTGTGTTACG CTAATGGCAT TAACCTCTAT 1320

GTAAAAATCA AAAACGATCC CTACAAAGAG GGAATGCTGT GTGGTTATGA GAGCGTTCAA 1380

AAACTGCTTT CACCACTAAG GGACAAGCTC AAATACGACA AGCAGAAGTT ACAAAAAGCG 1440

TTACTGAAAG ATTTAAAG 1458

(2) INFORMATION FOR SEQ ID NO: 52:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 303 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...303

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 52:

GTAGTAGGCA CAATGGAAGA CTTTTTGTAT AACACCTTAT ATTTCATAGA GGATTATAAG 60

TTGGTTGTTA TTTTTAGTTT CATAGGGTTA ATAGCGTTAT TTTTCCTCTA CAAATTCATA 120

AAAACTCAAA AAAAGGTTTT TAAAGATAAA GCTAACCAGC CTCAAAAGAA AAAAAGCTTT 180

AAAGAAATCA TTATAGATGG GCTGAAAGAA AGGGTTAAAA CCTTTGGCTT TTGGTTGCCA 240

AGCTATACTA TTACTATCCT ATTCTTTTAT CACATCAGGG TTATTTTTCT TGATTCTCTT 300

AGG 303

(2) INFORMATION FOR SEQ ID NO: 53:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 879 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori (ix) FEATURE:

(A) NAME/KEY: misc_feature (3) LOCATION 1...879

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 53:

AGAATGGCTC AAATTGTAAA AGGATCTGAC ATGTTTGAAG ATTTTTATCG CACTACCCTC 60

TCTTTTTTAA GGTCTTTATT GCTTTTATTG GGTTTATTGT TGCCGTTTTC GCTTTGTATA 120

GCTGATGAA ATATTAGCAT AAGTGATGAT TGGGATGAAA GGGCGCGAAA TCAGTGGGAT 180

GAAACTGCGC GAAATCATAA GACATATTAT TTTGAAAATG GTTTAGACCA TTTTAATCAA 240

GGCCAATACA AGCAAGCCTT TAAAGATTTT AAATTGGCGC AAGAATACAG CATCGGGCTT 300

GGCAACGTTT ATTTAGCCAA AATGTATTTG GAGGGAAAGG GCGTGAAAGT GGATTACAAA 360

AAAGCGCAAT TCTATGCACA AAACGCTATC AAAGGGTATG GGAGCGGGTT GTTAGGGGGC 420

GCTCTTATTT TAGGACGCAT GCAAGCAGAA GGCTTAGGGA TGAAAAAGGA TTTGAAACAA 480

GCACTCAAGA CTTACAGGCA TGTGGTTCGC ATGTTTTCTA ATAAAAGTGC AAATTTTGCT 540

AACAAATTTG GATCAAACCT TGCGGAATTT ACTAGTATGC TTATTGGATC GCGATTCATT 600

GATCTTTCAG GTTTGAGCGC GAATCCTATA AAATTTGGAA ATAAATTTGG AATACTTGTT 660

AAGAAAGCCC TTCAAATCAA AGATAATACA CTTTCTTGGG AAGACATTGC TGAAATTTCA 720

AGCAATATTA TTTTACTCAA ACAACAAATG GGGGAAATCC TTTATAGGAT TGGGATCGCT 780

TATAAAGAAG GGCTTGGCAC TAGAAAGAAA AAGGACAGGG CTAAAAAATT CTTGCAAAAA 840

TCCGCAGAAT TTGGCTATGA AAAAGCCATG GAAGCTCTG 879

(2) INFORMATION FOR SEQ ID NO: 54:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 243 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...243

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 54:

GACTTTCACG ATTTCTGTGC GAATATCCAT CATCGTATCC GTTGGAGGCA CAGGCATATA 60

GCCTCCTTGC TTTCCCGGTC TATGCCCAAA ATTCACGCCG TTTTCAAAGC TTTTATCCCT 120

ATTCCATTCG CCCTCTTCGC TATCCACTTC GTAGTATTGG GAATTGGAAG CGTCTTTAAT 180

CTTAATAGAA TCAAAGATAA AAAATTCATT CTCCGCGCCA AAATAAGCCA CATCGCCCAA 240

GCC 243

(2) INFORMATION FOR SEQ ID NO: 55:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 312 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double (D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...312

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 55:

AAAGCCATGC TTTCTTCTAC GAATGACATA CGGTATCAAA ACCCTAAAAA CAAGGCTTTG 60

AAAGGCGAAA TATTAGCGAA TCTGAAATTC ATAAAAAAAC TGCTTGGTAT TGGGTGTAAA 120

GACCCTAGCG CGTATGTCCA ATTAGGCGTG AGCAAGAGCG AAAAACAAGA AATTGAAAAC 180

AAGATAGAAG AAAGAAAACG TGCCAAAGAA CAAAAAGATT TTTTAAAAGC CGATAGCATC 240

AGAGAAGAGC TTTTACAACA AAAAATCGCT TTGATGGACA CCCCACAAGG CACGATTTGG 300

GAGAAGCTTT TT 312

(2) INFORMATION FOR SEQ ID NO: 56:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1587 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1587

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 56:

ATGAGAAAGG TTATCATAAT GAATGGTTAT TTGAGGGTAA AAACCCCGTA TTTTTTAGCG 60

TCGGTCGTTT TGACTTTTTG GACTTTTAAT TCTTTTATGA GCGCGAAAGA TAAGCACCAT 120

TTTTTAAAAA AAGTTACAAC CACCGAGCAA AAATTCAGTT CTAGTGCCCC AATTTCATGG 180

CAAAGCGAAG AGGTGCGTAA TTCCACAAGC TCTCGCACGG TGATTTCCAA CAAAGAACTC 240

AAAAAAACGG GGAATTTGAA TATTGAAAAC GCCTTGCAAA ATGTACCAGG GATTCAAATC 300

AGAGACGCTA CAGGCACGGG CGTGCTGCCT AAAATTTCGG TGCGCGGTTT TGGTGGGGGC 360

GGTAACGGGC ATAGCAACAC CAACATGATT TTAGTCAATG GTATCCCCAT TTATGGCGCG 420

CCGTATTCCA ATATTGAACT GGCGATTTTC CCTGTAACTT TCCAGTCAGT GGATAGGATT 480

GATGTGATTA AGGGGGGAAC GAGCGTCCAA TACGGCCCTA ACACTTTTGG AGGCGTGGTG 540

AATGTCATCA CTAAAGAAAT CCCCAAAGAG TGGGAAAATC AAGCGGCTGA AAGGATCACT 600 TTTTGGGGGC GCTCCTCTAA TGGGAATTTT GTCGATCCCA AAGAAAAAGG CAAGCCCTTA 660

GCCCAAACTT TAGGAAACCA AATGCTGTTT AACACTTATG GGCGAACGGC TGGGATGTTG 720

GGTAAATATA TAGGCATTAG CGCTCAAGGC AATTGGATTA ATGGGCAAGG TTTCAGGCAA 780

AATAGCCCTA CAAAGGTGCA AAACTACTTG TTGGATGCGA TTTATAAGAT CAATGCGACC 840

AATACTTTTA AAGCTTATTA CCAGTATTAT CAATACAACT CTTACCATCC AGGCACTTTG 900

AGCGCGCAAG ATTACGCCTA TAACCGCTTC ATCAATGAGC GCCCTGACAA TCAAGATGGA 960

GGGCGAGCCA AGCGCTTTGG GATCGTGTAT CAAAACTACT TTGGCGATCC GGATAGGAAA 1020

GTGGGGGGCG ATTTTAAATT CACTTATTTC ACGCATGACA TGAGTAGGGA TTTTGGGTTT 1080

TCCAACCAAT ACCAAAGCGT GTATATGAGC GGTCAAAATA AGATTTTACC CTTTAAAGGC 1140

AAGGGAGAAA TCAGCGCAAA AAACCCTAAT TGCGGTCTGT ATTCTTATAG CGACACGAAT 1200

AGCCCTTGCT GGCAATTTTT TGACAATATC CGCCGATCCG TGGTGAATGC CTTTGAGCCA 1260

AAACTCAATC TTATCGTCAA TACTGGTAAA GTCAAACAAA CTTTTAACAT GGGAATGCGC 1320

TTTTTAACTG AAGATTTATA CCGCCGATCC ACCACCAGGA AAAACCCTAG CATGCCTAAT 1380

AATGGGAGTG GGTTTGATGC AGGAACTTCA CTCAATAATT TCAACAATTA TACCGCTGTG 1440

TATGCCAGCG ATGAAATCAA TTTCAATAAC GGCATGCTAA CGATCACGCC GGGCTTGAGA 1500

TACACTTTTT TAAATTACGA AAAAAAAGAC GCTCCTCCCT TTAAGGTGGG TCAAACCCCA 1560

AAAACCACGA AAGAGCGTTA TAACCAA 1587

(2) INFORMATION FOR SEQ ID NO: 57:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 582 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...582

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 57:

CGGGTTGGAT TTCGCTCCTT TAGTGGTGGT CATTGTGCTG AAATTTTTAG ATTTAACCCT 60

CATCCAATGG CTTTTTGCGC TCGCCAAAAG CCTCTAAAGG AAATCATGCG TTTTTTTATT 120

TTATTTTTTA TGGGTATGCT TGGCGTTGGT TTTTCTCAAA CCGAGTTGGA TTTAAAGGAT 180

TTAGAAAAAA AGCCCGCCGG GATCGTTAGG GATTATTATT TATGGCGTTA TATTAGCGAT 240

AAAAAAACGA GTTTAGAAAA CGCTAAAAAA GCCTATGAAT TGACTCAAAA TAAAAACAGC 300

GCCCTACAAA AAGCCATGCA AGAAAAAGGC GTAGAAAATT CAGATAAAAG CCCTGATGCC 360

AAAATGCCTG AAGATATTTA TTGCAAGCAA ATTACCTTAG AAAGCATGTT AGAAACAACA 420

GACGCTTTCC AAGCGAGTTG TATCGCTATC GCTTTAAAAT CAAAAATCAG AGATTTTGAT 480

AAAATCCCCA TTCAAACCTT TAAACCTTTA CAAGAAAAAA TCAAAGAGGC TTACCCCATT 540

CTTTATGAAG AATTAGAAAT CTTGCAAAGT AAGAACGTGA GC 582

(2) INFORMATION FOR SEQ ID NO: 58:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 618 base pairs

(B) TYPE: nucleic acid (C) STRANDEDNESS. double

(D) TOPOLOGY- circular

(11) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL. NO

(iv) ANTI-SENSE- NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...618

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 58:

CACGCCTTGT ATTCGCCCAT CAAAATCGCT TTTGAAAAAG CCCTTAAAAA CGCTAAAGAA 60

TCCGTTTTTA TCGCTTCATC GTATTTTATT CCAGGTAAAA AGATAATGAA AATCTTTAAA 120

AATCAAATTT CTAAGGGGAT TGAATTGAAT ATTCTTACCA ATTCCCTTTC ATCTACGGAC 180

GCTATCGTGG TCTATGGGGC GTGGGAAAGG TATCGCAATA AATTAGTGCG AATGGGCGCG 240

AATGTCTATG AAATACGAAA CGATTTTTTC AACCGCCAGA TTAAAGGGCG CTTTAGCACC 300

AAACATTCCT TACACGGCAA GACAATTGTT TTTGACGATG CCCTAACGCT TCTAGGGAGT 360

TTTAATATTG ATCCGCGCTC TGCATATATT AACACTGAAA GTGCGGTCTT GTTTGACAAC 420

CCGTCTTTTG CCAAAAGGGT GCGTTTGTCG CTTAAAGATC ATGCCCAACA ATCATGGCAT 480

TTAGTCTTGT ATCGGCATAG AGTGATTTGG GAAGCTACAG AAGAAGGCAT CTTAATCCAT 540

GAAAAAAACT CGCCTGATAC CTCTTTCTTT TTGCGTTTGA TTAAAGAATG GTCTAAAGTC 600

CTTCCTGAAA GAGAACTT 618

(2) INFORMATION FOR SEQ ID NO: 59:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1326 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...1326

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 59:

GGAAAAATTA AAGGTGTGAT GATGAAATTT TTTCTTTTAA AGAAATTCAG CGAATTTTTA 60

AACACTCAAA CGCATTTTAA CCTCAAACGC TTGAACGCGT CTAGTTTTTT ATTAGAGACT 120

TTTTCTAAAG AAAAACACGC CTTTGTTGTG GATTTGAGCG CGCCTTATAT TGGTTTGTCC 180

AAAAAACCCC CAGAGAGCGT TTTAAAAAAC ACTTTAGCGT TAGATTTTTG TTTGAATAAA 240 TTCACCAAAA ACGCCAAAAT TTTACAAGCA AACGTCATTG ATAACGATCG GATTTTAGAA 300

ATCAAGGGCG CTAAAGATTT AGCTTATAAG AGTGAAACTT TTATTTTGCG TTTAGAAATG 360

ATCCCTAAAA AAGCCAATCT CATGATTTTA GATCAAGAAA AATGCGTGAT AGAGGCTTTT 420

CGTTTTAATG ACAGGGTGGC TAAAAACGAT ATTTTAGGGG CATTGCCTCC TAATATTTAC 480

GAGCATCAAG AAGAGGATTT GGATTTTAAG GGATTGTTGG ACATTTTAGA AAAAGATTTT 540

TTATCCTATC AGCACAAAGA ATTGGAACAC AAAAAAAATC AAATCATCAA GCGATTAAAC 600

GCCCAAAAAG AACGCTTGAA AGAAAAATTA GAAAAACTAG AAGATCCTAA AACTTTACAG 660

CTGGAAGCGA AAGAATTGCA AACTCAAGCC TCATTGTTGC TCACTTACCA GCATTTAATC 720

AACAGGCGTG AAAATCGCGT GATTTTAAAG GATTTTGAAG ATAAAGAATG CATGATTGAA 780

ATTGATAAGA GCATGCCCTT AAACGCTTTT ATCAATAAAA AATTCACTCT CAGCAAGAAA 840

AAGAAACAAA AATCGCAATT CTTGTATTTA GAAGAAGAGA ATCTGAAAGA AAAAATCGCT 900

TTTAAGGAAA ATCAAATCAA CTATGTTAGA GACGCTGCAG AAGAAAGCGT TTTAGAAATG 960

TTTATGCCGG TAAAAAACTC TAAAATCAAA CGCCCGATGA ACGGGTATGA AGTGCTGTAT 1020

TATAAGGATT TTAAAATCGG TTTAGGGAAA AACCAAAAAG AGAATATCAA GCTTTTACAA 1080

GACGCAAGAG CGAATGATTT GTGGATGCAT GTGAGAGATA TTCCTGGATC GCATTTGATC 1140

GTTTTTTGCC AAAAGAATAC GCCTAAAGAT GAGGTCATTA TGGAATTAGC CAAAATGTTG 1200

ATTAAAATGC AAAAAGATGC GTTTAATGGT TACGAGATTG ACTACACGCA ACGAAAATTT 1260

GTCAAAATCA TCAAAGGAGC TCATGTCATT TACTCAAAAT ACCGAACTAT TAGTCTAAAG 1320

GACACT 1326

(2) INFORMATION FOR SEQ ID NO: 60:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 879 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...879

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 60:

GGATTTATGA TGATTTTCAT TGACGCATGT TTTAGAAAGG AAACGCCTTA CACACCCATT 60

TGGATGATGA GGCAAGCGGG GCGTTACCTT AGCGAATACC AAGAGAGCCG TAAAAAAGCG 120

GGGAGCCTCT TGGAATTGTG TAAAAATAGC GATTTAGCCA CAGAAGTTAC CCTACAGCCG 180

GTAGAGATTT TAGGCGTGGA TGCGGCTATT TTGTTTAGCG ATATTTTAGT AGTGCCTTTG 240

GAAATGGGCT TGAATTTGGA GTTTATCCCC AAAAAGGGGC CGCATTTTTT AGAGACGATT 300

ACGGATTTAA AAAGCGTGGA AAGCCTAAAA GTAGGGGTTT ATAAACAACT AAACTATGTC 360

TATGATACGA TTTCTCAAAC GCGCCAAAAG CTTTCTAAAG AGAAAGCGCT AATCGGTTTT 420

TGCGGATCGC CTTGGACTTT AGCGACTTAC ATGATAGAAG GCGAGGGGAG CAAATCGTAT 480

GCCAAAAGCA AGAAAATGCT TTATAGCGAG CCTGAAGTTT TAAAAGCGCT TTTAGAAAAG 540

TTAAGCCTTG AATTGATAGA GTATTTGAGC CTTCAAATCC AAGCAGGGGT CAATGCAGTG 600

ATGATCTTTG ACTCATGGGC TAGCGCTTTA GAAAAAGAAG CGTATTTGGA ATTCAGTTGG 660

GATTATTTGA AAAAAATCTC TAAAGAGCTT AAAAAACGCT ATGCGCACAT CCCAGTTATC 720

CTTTTCCCTA AAGGGATTGG CGCTTATTTG GATAGCATAG ATGGGGAATT TGATTTGTTT 780

GGCTTGGATG GGGGCACGCC TTTAACTGCG GCAAAAAAAA AATTAGCGGT AATTATTTTT 840 TTGCAAGGAA TTTACAACCC ACCCGCCTTT ATGATAAAA 879

(2) INFORMATION FOR SEQ ID NO: 61:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 576 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...576

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 61:

AGGGTGTTTT TGACTAAAAA ATTCATGTCT TGGATGGTGG TTATCGGGGC TTTAATTTGC 60

GTGCTTTTAG GGGTGTTTAT CTTCTTCACT AGCATGTCGG TTAAAAAATC TTTAACCGCT 120

TATCTTAACG CTTATTTAGA GCAACGCCCA AATATCGAGG GCATGGGGAT TATAGGAGTT 180

CCTTTTAAAT GCGAAAGGTT TTTTAAAATC GCATGCGTTT CTAAAGAACT TCGTTTTTTA 240

AATCCTCAAA ACTCTCCTAT TATGGATTTT AAAAATTTAG AGATCAAGCT CCATTCTTTA 300

GATAAAAGCT CTCTTACCCT TTCTATCCAT TCTCAAATCC AATCCCCTAT TTTAGAACAA 360

TCCATTCAGC AAAAAATCAG CCAAATCCCC TTAAAAAACT TGAATGCCTT ATTGGAAAAA 420

TTCAAACCCA CGCGCTTGAA TTGCTCTTTA ACATTCAACG CTTTAGATGA AAAAACCTTA 480

AACGATAATT TAAAATGCGA TTTGACTAAT GCAGAGAATC TCCTGCTACA CTTTTTTTCA 540

AGAGGGTTTA ATGGAGGCGC AAGAAAATCT CTCCCT 576

(2) INFORMATION FOR SEQ ID NO: 62:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1110 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1110 (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 62:

CAGGATCAAC CCATGCAATT TCAAAAAACC TTACTTTCTT TATCTTTATT ATTTTTATCT 60

TATTGTATCG CTGAAGAAAA TGGGGCGTAT GCGAGCGTGG GTTTTGAATA TTCCATCAGT 120

CATGCCGTTG AACACAATAA CCCTTTTTTG AATCAAGAAC GCATCCAAAC GATTTCTAAC 180

GCTCAAAACA AAATCTATAA ACTCAATCAA GTCAAAAATG AAATCACAAA CATGCCCAAC 240

ACCTTTAACT ACATCAACAA CGCTTTAAAA AACAATGCTA AATTAACCCC TACTGAAAAG 300

CAAGCCGAAA CCTACTACCT GCAATCTACC CTTCAAAACA TTGAAAAAAT AGTCATGCTT 360

AGCGGGGGCG TTGCGTCTAA CCCTAAATTA GCCCAAGCGT TAGAAAAAAT GCAAGAACCC 420

ATTACTAACC CTTTAGAATT GGTAGAAAAC TTAAAAAATT TAGAATTACA ATTCAGCCAA 480

TCTCAAAACA GCATGCTTTC TTCTTTGTCT TCTCAGATCG CTCAAATTTC AAATTCTTTG 540

AACGCGCTTG ATCCCAGCTC TTATTCTAAA AACGTTTCAA GCATGTATGG GGTAGGTTTG 600

AGCGTAGGGT ATAAGCATTT CTTTACCAAG AAAAAAAATC AAGGGTTTCG TTATTACTTA 660

TTCTATGACT ATGGTTACAC TAATTTTGGT TTTGTGGGTA ATGGCTTTGA TGGTTTAGGC 720

AAAATGAATA ACCACCTCTA TGGGCTTGGC ATAGATTATC TTTTCAATTT CATTGATAAT 780

GCGCAAAAAC ATTCGAGCGT GGGGTTTTAT GTAGGCTTTG CTTTAGCGGG GAGTTCGTGG 840

GTAGGGAGTG GTTTAGGCAT GTGGGTGAGT CAAATGGATT TCATCAACAA CTATTTGACG 900

GATTATCGGG CTAAAATGCA CACGAGTTTT TTCCAAATCC CTTTGAATTT TGGGGTTCGT 960

GTGAATGTGG ATAGGCACAA TGGTTTTGAA ATGGGCTTAA AGATCCCTTT AGCGGTCAAT 1020

TCCTTTTATG AAACGCATGG CAAGGGGTTA AACGCTTCCC TCTTTTTCAA ACGCCTTGTC 1080

ATGTTTAACG TGAGTTATGT TTATAGTTTT 1110

(2) INFORMATION FOR SEQ ID NO: 63:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 729 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL : NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...729

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 63:

GAACCCATGC CTATGGGCAA AGCGCTCAAA GAATACCAGA TCAAAAAAAC CAGAGATGTG 60

GGCATTGGCG CTAAAAACAG CGAAATCATG ACCTCCGCTC AAGTGGAATT AGGCAAAATG 120

CTCTATTTTG ACCCTAGGAT TTCCACTTCC TATCTTGTGT CTTGCAACAC ATGCCATAAT 180

TTGGGCTTAG GCGGGGTGGA TCTAATCCCA AGCGCTATAG GCTCTCAATG GAAGAAAAAC 240

CCCCACCTTT TAAGTTCCCC AACGGTGTAT AACTCTGTGT TTAACGATGT GCAGTTTTGG 300

GATGGTAGGG TTACGCATTT AAACGAACAA GCGCAAGGGC CAATCCAATC TTCTTTTGAA 360

ATGGGGGCTG ATCCTAAAGT CGTGGTAGAA AAAATCAATT CCATACCAGG CTATGTCAAG 420

CTCTTTAGAA AAGCTTATGG CTCTAAAGTC AAAATTGATT TTAAATTGAT CGCTGATAGT 480

ATCGCTATGT TTGAAGCCAC GCTCATTACC CCAAGCCGTT ACGATGATTT TTTAAGGGGC 540

AATCCTAAAG CGCTCAGTAA AGCCGAAAAA GAAGGGCTGG ATTTATTCAT TTCTAAAGGC 600

TGTGTGGCGT GTCATAATGG CATCAATCTT GGGGGGACGA TGCAGCCTTT TGGGGTGGTC 660

AAACCTTATA AATTCGCTAA TGTGGGCGAT TTCAAGGGCG ATAAAAACGG GCTTGTGAAA 720 GTGCCTACT 729

(2) INFORMATION FOR SEQ ID NO- 64

(l) SEQUENCE CHARACTERISTICS

(A) LENGTH 702 base pairs (3) TYPE nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY, circular

(ii) MOLECULE TYPE- DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...702

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 64:

AACGATTTTT GGAGAAAGGA AATAACCATG AGAGCTACGG CGATAAAAAT CTTTTCATTC 60

TCATCAGCGC TCGCCCTATT GCTTCAGGGT TGCTTGAGCA TTAATTTAAA ACAAATGCTG 120

CCAGAAATCA GAACTTATGA TTTAAATGCG AGTTCTTTTG AAATGACGCA ATGCCCTAAA 180

CCTTTGACTG AAGTGAGGCT CATTATCATT TTGAGCGCGG ATTTATTCAA CACTAAAGAG 240

ATCGTGTTTA AAGCGCAAGA CGGGCAGATT ACGCATGGGA AGCACCAAAA ATGGATAGAC 300

TTGCCTCGCA ACATGTTAAA AACCATGTTC ATGCAAGAAG CGCAAAAAGC ATGCTTAGGC 360

GTGGCTTTGC CCCCTTATGG CGCGGGCGCG CCCACTTATG CGGTTCGTTT TACGATTTTA 420

TCGTTTTCTC TTTTAGAAAA AGAAAATTCT ACTTACAGGG CGGAATTCGC GCTAGGCTAT 480

GATATTAGCG TGAAAGGCGA TTCGCATTCT GGAGTGATCA TTAAGCATGA AAATATTTCT 540

AGCTTGGAAA ATAAAACGAC CAAAACGAGT AAAAATGGCA GTCAAGATTT CCAAGAAAGC 600

GCGATACAAT CCCTCCAACA TGTCAGCACG CAAGCGATGC AAGAAGCGAT TTCTTTGATT 660

AAAAAAGCGG TTGAAGCGCA AAGCGTAAGC CCGTTAAAAA AA 702

(2) INFORMATION FOR SEQ ID NO: 65:

(l) SEQUENCE CHARACTERISTICS

(A) LENGTH: 849 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE.

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature (B) LOCATION 1...849

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 65:

AGGCAATTTA TTCAATTCAA CACGAGGAGA GAAATTTTGG AAAGGCATGT GAATTACACT 60

TTAATCGGCG GGCTCTTCTT TTTATGCTTA GTGTGCATGG TAGGCTTTAT TTTATGGCTA 120

GGCCATTTGG GATTAGATGA TGGGAAGTAT TATGAATATG TGGTCTATAC GGACAAAGAC 180

TTGGGAGGCA TTGCGACCAA CTCGCCCATT AATTACAAAG GGATTCAAGT GGGTAATGTC 240

ATCAAAGTGG GTTTTGCAAA GGATAAAGTG GGGGTGGTCC GTTTGGATTT GATGATCAAA 300

TCCAGCGTTA AGATCCGTAA AGATTCCAAA GTGGCGGTTT CTTCTAGAGG GTTTATGGGG 360

TTAAAATTTT TAGCCTTAGA GCAAAGCCAC AATGAAGAAT TTTATGGTAG CGGCGATAAA 420

GGGGAGCGGA TTTTAATCTT TAAAGAAGGG CTTATGGATC GCTTGAGCGG TGATGCTAAT 480

CAAGTGGTGC AAGAAGTGAT GAAAGCGATC AGGAATGTGA ATAGGATTTT AGACGATGAA 540

AACGTGGAGA AATTCAAGCA CATTCTCGCT TCAGTGGATG ATCTCATCGC TAACTTGGAT 600

TCAAGAAAGA CTCAATTTGA TTCCTTGATC AACAACGCTA ACAACCTTGT TTCTAATGTC 660

AATAATGTGG CTTTGGATGT GGATAAACGC GTCAAACAGG GGCAATACGA CTTTAAGGCG 720

ATGTTCACTC CTTTAATCAT GCAAGCGCAG TTGAGCTTAA GAAACATTGA TAATTTTGTG 780

GAAAAAGGCT CTGCTTTGAT AGATAAATTT GACGCTAACC CCTATAAAAC GATTTTTGGA 840

GAAAGGAAA 849

(2) INFORMATION FOR SEQ ID NO: 66:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 453 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...453

(x-i) SEQUENCE DESCRIPTION: SEQ ID NO: 66:

AGCAGCTCAC AATCTATAGC CTTACTCATT GGCTTGTGGT TTGGGTTTCA AAAACGCATC 60

GCTTTGGGGG TGTGGTTTTT CTTTAGCATC TTATTAGGTG AATTCACCTT AAAATCCCTT 120

AAGCTTTTAG TGGCGCGCCC ACGGCCTGTA ACCAATGGCG AATTGGTTTT TGCGCATGGC 180

TTTAGTTTCC CTAGCGGGCA TGCTTTAGCT TCAGCGCTTT TTTACGGCTC TTTGGCGTTG 240

TTGTTATGCT ATTCTAACGC AAACAATCGC ATTAAAACTA TTGGTGCTAT TATTTTACTT 300

TTTTGGATTT TTTTAATGGC GTATGATAGG GTTTATTTAG GGGTGCATTA CCCTAGCGAT 360

GTTTTAGGAG GGTTTTTATT AGGGATTGCT TGGTCGTGCT GCTCTTTAGC GCTTTATTTG 420

GGGTTTTTGA AACGCCCTTA TAAAGCCGCT TAA 453

(2) INFORMATION FOR SEQ ID NO: 67:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 219 base pairs

(B) TYPE: nucleic acid (C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...219

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 67:

ATGATGGATT TAGAAAGTTT GAGAGGTTTT GCGTATGCGT TTTTTACCAT TCTTTTTACG 60

CTCTTTTTGT ATGCTTATAT TTTTAGCATG TATAGAAAGC AAAAAAAGGG CATCGTGGAT 120

TATGAGCGAT ACGGGTATTT AGCGTTAAAT GATGCTTTAG AAGACGAGTT GATTGAACCA 180

CGCCATAAAG AAGTTCATGA TAAAGGCATA AAGGAAAGT 219

(2) INFORMATION FOR SEQ ID NO: 68:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 300 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...300

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 68:

GGAAATTTAA TGGGACAAAC TAAAGAAATT ATAACGACGC TTTTACCCCT TTTGGTGTTG 60

TTTCTTATTT TTTATTTTTT GATCGTTCGC CCGCAACGCC AACAGCAAAA AAAGCATAAA 120

GAAATGATAG AGGGCTTGAC TAAGGGCGAT AAAATTGTCA CTCAAGGAGG GCTGATCGTT 180

GAAGTGCTTA AAGCGGAAGC GAATTTTTTT AGCGTGAAAC TCAATGATGA CACCACCGCT 240

AAACTTTCTA AAAACTATGT AGCGTTCAAA TTAGACGAAG AAACAACACC CAACAACAAC 300

(2) INFORMATION FOR SEQ ID NO: 69:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 477 base pairs

(B) TYPE: nucleic acid (C) STRANDEDNESS. double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi ) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...477

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 69:

ATGAAACTTT TTAACCCTCG TTTAATCGTT TTTATATTCG CGCTTCTTTT AGGGGTAGGG 60

TTTTCTGTGC CTTCTTTGCT AGAAACTAAA GGCCCTAAAA TCACTTTAGG TTTGGATTTA 120

AGGGGGGGGT TGAACATGCT TTTAGGGGTG CAAACCGATG AGGCTTTAAA AAACAAGTAT 180

TTAAGCCTAG CGTCTGCTTT AGAATACAAC GCTAAAAAGC AAAATATCTT GCTTAAAGAC 240

ATTAAATCCA GTTTAGAGGG GATCAGTTTT GAGCTTTTAG ATGAAGATGA GGCGAAAAAA 300

TTAGACGCGC TTTTATTGGA ATTGCAAGGT CATAGCCAGT TTGAAATCAA AAAAGAAGCG 360

GAGTTTTATA GCGTGAAACT CACCCCTTTA GAGCAAGAGG AATTGCGTAA AAACACGATC 420

TTGCAAGTGA TAGGGATCAT TCGTATCCGC TTGGATCATT TGGCTTGGCA GAGCCTG 477

(2) INFORMATION FOR SEQ ID NO: 70:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 264 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(Vl) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...264

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 70:

GGGAATGTTA AAGTGAATAA AAAGCACCGC TTGGCTTTTT TAGGGCTAAT TGTTGGGGTT 60

CTATTCTTCT TTAGCGCGTG CCAACACCGC CTGCACATGG GGTATTATTC AGAAGTTACA 120

GGGGATTATT TGTTCAATTA TAATTCCACT ATCGTGGTGG CTTATGACAG AAGCGATGCG 180

ATGACTTCTT ATTATATCAA TGTGATTGTT TATGAATTGC AAAAATTAGG CTTTTATAAT 240

GTCTTCACGC AAGCGAATTC CCGC 264

(2) INFORMATION FOR SEQ ID NO: 71: (1) SEQUENCE CHARACTERISTICS

(A) LENGTH 495 base pairs

(B) TYPE nucleic acid

(C) STRANDEDNESS double

(D) TOPOLOGY circular

(n) MOLECULE TYPE- DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM. Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...495

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 71:

AAAGCGTTGA TGGTAGGAAT GAAAACTGGA GCATGGACCG GTTTAAAACT TTTTGCACAG 60

CCTTTGTTGG TGGTTTTAGC GTTCATGTTG TTGTATGCTT TAGCGCATGC TGTGCTTGGT 120

TTTTACGTGA AAAAAGACAG CGCTCCAATG AGTCCAAATG TAGAAAAAAG CGAGACAGAG 180

CGCCAAAACA GCACGTTTTC GCCTAAAGAA GAAGCCAACG CAACCACAAC CGCCACAGAA 240

CAAAACCCCA CCAAAGACAC AGTGCCACCT TTAGACACAG CCACACAAAA ACAAGAGATT 300

AAACAAGAGA TTAAACAAGA GATTAAACAA GAGATTAAAC AAGAGATTAA ACAAGAGATT 360

AAACAAGAGA TTAAACAAGA AACTAAACAA GAGCAAGAAA AAGAAAATAA GCCTAAACAA 420

AACAGTGTCT CGCCCGTTCA AAACGATCAA AAAACCCCCA CAACCCCCTT AATGGGTAAA 480

AAAACCTCTA GAGTA 495

(2) INFORMATION FOR SEQ ID NO: 72:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 291 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...291

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 72:

ATGCTTTATG CATCAAAAGC GCGTTTATTT TTACAAATCA AAGGAAAGTT TATGTTAAGA 60 ATTTTAATCC CCTTACTCAT TATTGTGTGG GTTTTATGGC GTTTGTTTTT GAGGCAAAAA 120 CCCCACAAAG ATGACCACAG AGACAACCAC TCTTACACGC AACAAACCCC CAAAGAATTA 180 GAAGATCACA TGATTGTATG CTCTAAATGC CAAACTTATG TCTCTAGTAA AGACGCCATT 240 TATAGTGGGG CGGTAGCCTA TTGCAGTGAA ACTTGTTTGA AGGATAAGGG G 291

(2) INFORMATION FOR SEQ ID NO: 73:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 252 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...252

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 73:

AAAACAATCA ATAAATTAAG GATTATAATG AAACCAACGA ACGAACCTAA AAAACCTTTT 60

TTTCAAAGTC CCATTGTTCT TGCGGTTCTT GGAGGGATTT TACTCATTTT TTTCCTACGC 120

TCTTTCAATT CTGATGGCAG TTTTTCGGAC AATTTCTTAG CTTCTAGCAC TAAAAATGTG 180

AGCTACCATG AAATCAAACA ACTCATCAGC AATAATGAAG TGGAAAATGT AAGTATCGGT 240

CAAACTTTAA TC 252

(2) INFORMATION FOR SEQ ID NO: 74:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 690 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(i^'i) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...690

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 74: TTCAAAAATA ATAAGACACC CCTAACTTTT GAGCGTGATA AAGGGTCATT GGATGGTTTG 60 AAAAAAGAAA GACAAGGATT TTACAAGCAA GTGCATTATT TAAGAATTTT AATACTGAGT 120

ATGAGTTTTT TAAATATTTT AAATGCTGAA AATTTGAGTT ACATGTCTTC TTCTTATCAA 180

ATAGGCACGG TGTTTATGCG CCCCTTAAAC ACCAACAAAC TTTTACAAGG GGCTTCAATC 240

CTTCAAGGCT ATGAAGTGAA TCCTAAAAAC GACTGGGCTT ATTCTAGGTA TTATTTCTTT 300

ATAGATTATG GTAATGTGCT TTTCAATAAC GATTCCACTT TGCAAGCGAA CATGTTCACT 360

TATGGGGTGG GAGGAGATTT TATGGTCGCT TACGCTAAAA ACCCTATCAA CCGCTGGGCT 420

TTTTTCTTTG GTTTGCAACT AGCGGCTAAC ACATGGATAC TCAATAATAA AGTCAAAGAT 480

TTGGTGGTGA ATACTTGGGA TTCATTGAAA GATTTCAATT TTCATAACAC TTATTTTAGG 540

GCTATCGGGA AATTTGGGGT GCAGTTTCGC ACGATCGTTT TGTATCATAA GGTGGATGTG 600

GAAATTGGCA TGAAAATCTT TTTAACGCCT GAAAGGCGCA GCTTGTTTGA AAGGAGTTTT 660

TTGTTTTTTG TTTCGCACTC GTGGCATTTT 690

(2) INFORMATION FOR SEQ ID NO: 75:

(l) SEQUENCE CHARACTERISTICS

(A) LENGTH: 627 base pairs

(B) TYPE, nucleic acid

(C) STRANDEDNESS- double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...627

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 75:

GGAATTTGTT TGAAGTTTCA AATTGTGAGT TTGTTATTGG CTTTTTTATT AGCCTCTTGT 60

TTGCCCCCTA AGGGCCATCA TTCTGGTTTG GTGAATATGT ATATTGCGCA TCAAGGCCAG 120

AGCGTACGCA CTTATTGGCG CAAAGTGGAT AGAGGAGTTG TCGCCAAACA CAATGAAACG 180

CTTAAAGAAA ACCCCAAAAT AAAGCTCAAA GACCCTAAGG GGCCTTTGTT CATGCTAGGG 240

AGCAATCGTT TCATGCTTTT ATGGAAAAAC CGCTATACTT TAGCTAAAGT CCAATCGTTC 300

AAGCTAGAGC CTGGGTTTTA TTACTTGGAT TCTTTTAGCG TGGAAACTCA AAAAGGCATC 360

TTGCAAAGCG CTCCTGGCTA TTCATACACC AAAAATGGCT ACGATTTTAA GAACAACCGC 420

CCCTTTTTCC TAGCCTTTGA AGTCAAACCT GACAGCAAGA TCGTTCTCCC TAGCGTGGAA 480

TTGAGCTTGA TTAAAACCCC TAGAGGCTTT TTAGGGGTGT TTTTATTTGA CAACAACGAA 540

AAGGGGGCTA ATACCCCATG GATTGAGGGG AGCTTGAATT TAAAGCTTAA AAACGCTTCT 600

TTTAAAGACG CATGGGAGTT GGAACGA 627

(2) INFORMATION FOR SEQ ID NO: 76-

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 510 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic) (m) HYPOTHETICAL: NO

(iv) ANTI-SENSE NO

(vi) ORIGINAL SOURCE -

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE-

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...510

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 76:

AAACCCTTTG GCTATCTCGG GCTATTGTAT AAGCAAGGGA CGCAAAAAAA CCCTCACAGC 60

TATGTGGGGG CTCCAGCGCG TCTTGGGGTG GATTTTTCTT ATAGCAATGG GTGGTCGTTT 120

GGTATTGGGG CTATTGGGGC TTGGAATATT TATAACAAAC AGCGTTTGGC TAACCTTTAC 180

ATCAGTCTAG GGAATTTTTT TGGTAACCCT AACAACGTTA AGCCTTATTT GAGCGCCGGC 240

GATGTTTCTG ATGCGTATCT TCAATACGCT AACCAGCGTT TTAAAATCGC TTTAGGGCGT 300

TTTAATACCG ATTTTGTGGA TTTTGATTGG ATAGGGGGCA ATATTCAAGG GGTCTCTGTG 360

GCTTTCAAGC AAAATTCCAT GCGTTATTTT GGGATTTTTA TGGATAGCAT GCTTTATAAT 420

GGGCATCAAA TCAATAAAGA GCAAGGGAAT CGGATCGCCA CTTTCCTAAA CGCTCTAGCT 480

CTTATGATCC TGTGTCTAAA CGCTTGTATG 510

(2) INFORMATION FOR SEQ ID NO: 77:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 585 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...585

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 77:

TTAGGATCAC CCATGCAATT TCAAAAAACC TTATCTTCCT TATCTTTATT TTTATCTTTA 60

TCTTTATTCT TATCTTTTAG TATCGCTGAA GAAAATGGGG CGTATGCGAG CGTGGGTTTT 120

GAATATTCCA TTAGTCATGC CGTTGAGCAC AATAATCCCT TTTTAAATCA AGAACGCATC 180

CAAACGATTT CTAACGCTCA AAACCAAATC TATAAACTCA ATCAAATTGA AAATGAAATC 240

ACAAACATGC AAAACACCTT TAACTACACC AACAACGCTT TGAAAAACAA TGCTAAATTA 300

ACCCCCACTG AAATGCAAGC CGAACAATAC TACCTCCAAT CCACCCTTCA AAACATTGAA 360

AAAATAGTCA TGCTTAGCGG TGGCGTTGCG TCTAACCCTA AACTAGTCCA AGCGTTAGAA 420

AAAATGCAAG AACCCATTAC TAACCCTTTA GAATTGGTAG AAAACTTAAA AAATTTAGAA 480

TTACAATTCA GCCAATCTCA AAACAGCATG CTTTCTTCTT TGTCTTCTCA GATCGCTCAA 540

ATTTCAAATT CTTTGAACGC GCTTGATCCC AGCTCTTATT CTAAA 585 (2) INFORMATION FOR SEQ ID NO.78

(l) SEQUENCE CHARACTERISTICS

(A) LENGTH. 216 base pairs

(B) TYPE, nucleic acid

(C) STRANDEDNESS. double

(D) TOPOLOGY, circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...216

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 78:

AAAGGCAAGG TCATGAATAG TTCTAACCTC AAAAATTGGC TATTCCCCAC TATTTGCTTT 60

TTTTTATTTT GTTATATTTT AATTTTTTTG ATATTTTTTA TGTTTAAAAA CTTGCAATCG 120

CAATCTTTTG GCTCTGTGGC AGAAACCGGA AAAAAACCCA TCACCACCAC CAAGAAATTT 180

GGTAAGGAAT TGCAAAAACA GATTTCAAAA ATCCAT 216

(2) INFORMATION FOR SEQ ID NO: 79:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 834 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(lil) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE.

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...834

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 79:

TTGATGCGTA AGGTTTTATA CGCTCTCATG GGCTTTTTGT TGGTTTTTAG TGCTTTAAAA 60

GCCGATGATT TTTTAGAAGA AGCGAACGAA ACAGCCCCAG CGAATTTAAA CCACCCCATG 120

CAGGATTTAA ACGCCATTCA AGGGAGCTTT TTTGACAAAA ACCGCTCCAA AATGTCCAAC 180

ACTTTGAACA TTGATTACTT TCAAGGGCAA ACTTATAAAA TCCGCTTGCG TTATGCGATG 240

GCGACTTTAT TGTTTTTTTC AAAACCCATT AGCGATTTTG TTTTGGGGGA TAAGGTGGGT 300

TTTGATGCGA AAATTTTAGA AAGCAATGAT CGCATTTTAC TCATCAAACC CTTACAAATC 360 GGCGTGGATT CTAATATCAG CGTGATTGAT AGCGAGGGTA AGATTTTTTC TTTCTATGTG 420

TTTTCTACCA CTTTCACCAG CTCCAAACAC CCTAATTTAC AGGTTTTTAT AGAAGATAAA 480

AACTATTACA CTAACGCTTT TATCAAGCCC CAAAAAGAAA ATCAAGAAAA TATGTCTGAA 540

AATGCCCCTA AAGATGCCCA AAAAAATAAT AAGCCCCTAA AAGAAGAAAA AGAAGAAACT 600

AAAGAAAAAG AAGAAGAGAC TATAATTATT GGCGATAACA CCAACGCGAT GAAAATTATT 660

AAAAAAGACA TCCAAAAAGG CTATAAGGCT TTAAAAAGCT CTCAAAGGAA ATGGTATTGT 720

TTATGGGCTT GTTCTAAAAA ATCCAAACTC TCCTTAATGC CTAAAGAAAT CTTTAACGAC 780

AAGCAATTCA CTTATTTCAA ATTTGACAAA AGATTAGCAC TCTCTAAATC CCGG 834

(2) INFORMATION FOR SEQ ID NO: 80:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 180 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...180

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 80:

TATCGTGAGA TGGATTATGC GGTGTTTAGC ATGACAATCC ACCCTGATGT GAGCGCCCGT 60 CCGCAAGTGT TGCTCATGCA TGAAAAAATC ATTGAGCATA TCAACCAGCA CGAGGGCGTG 120 GCTTGGGTAA CGTTCAATGA AATCGCTGAT GATTTCTTAA AACGAAACCC TAGGAAAAAA 180

(2) INFORMATION FOR SEQ ID NO: 81:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 237 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...237 (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 81:

CTTGTGTTAC AAGGGGCTGA GGTTTTAATC TATCCTAGTG CGTTTGGCAA AGCTAGGGCT 60

TATAATTGGG ATTTGTTGAG CAAAGCTAGA GCGTTAGAAA ATGGCTGTTT TGTGTGCGCT 120

TGCAATCATA GTGGGGAAGA AACTAACGCT AAATTAAAAC AAACGCTAGA ATTTGCCGGT 180

GATTCAAGGA ATCATCGCAC CCAATGGGAA AATCATCGCC CAAGCCACCA AGCTTAA 237

(2) INFORMATION FOR SEQ ID NO: 82:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 183 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...183

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 82:

AATTTGCCGG TGATTCAAGG AATCATCGCA CCCAATGGGA AAATCATCGC CCAAGCCACC 60

AAGCTTAATG AAGTCATTAT CGCCGAAATG GATTTAAACG AAGTGGCACT GCAACGCCAA 120

AAAATCCCTT ATTTACAAGA TTTTGACACC AAACTCACCA AAAAGGGGTT TGGAAAACTC 180

ACT 183

(2) INFORMATION FOR SEQ ID NO: 83:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 486 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...486

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 83: ATCATTATGT TTGGCATGGG CTTTTTTGAA ATCCTTGTGG TGTTGATTGT AGCGATTATT 60

TTTTTAGGAC CAGAAAAATT CCCTCAAGCT GTCGTGGATA TAGTGAAATT TTTTCGCGCG 120

GTTAAAAAAA CGCTCAATGA CGCTAAGGAC ACTTTAGATA AAGAAATCAA TATTGAAGAA 180

ATCAAAAAAG AAACCTTAGA GTATCAAAAA CTCTTTGAAA ACAAAGTGGA GAGTCTTAAA 240

GGCGTTAAGA TTGAAGAATT AGAAGACGCT AAAGTAACTG CAGAAAATGA GATTAAAAGC 300

ATTCAGGATT TGATGCAAGA TTATAAACGC AGCTTAGAAA CCAACACGAT TCCTAACCAT 360

TTAAATGAAG AAGTTTCCAA TGAAGAAGCT TTAAATAAAG AAGTTTCAAG CGATGAATCT 420

CCTAAAGAAG TCCAATTAAC AACCGATAAC AACGCCAAAG AACACGACAA AGAAAAAGAG 480

CATGTT 486

(2) INFORMATION FOR SEQ ID NO: 84:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 555 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...555

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 84:

CGCTATCGGT CCTTTAGCCG CAATCAGTCA AACTTTAGAA GATGCGAGCA GCCCTATGGG 60

AGTACTTTAA ACTCTGTGCC GTTGTGGATT ATGGTAGTAG GGGCAGCTGG GATCGCTTTA 120

GGCTTGAGCT TGTATGGGCC AAAGCTCATT AAAACGGTGG GGTCTGAAAT CACAGAATTA 180

GACAAAATGC AAGCTTTTTG CATCGCGCTT TCAGCGGTCA TCACCGTGCT TTTAGCCTCT 240

CAATTAGGCT TACCGGTAAG CTCTACGCAT ATTGTGGTGG GCGCGGTGTT TGGGGTGGGC 300

TTTTTAAGGG AGCGTTTGAG GGAGCAATCC AGAAGGCGTT TTGCTAGAAT CAGAGACAAC 360

ATTGTAGCGG CGCACTTTGG GGAAGATTTA GAAGAAATTG AAGGCTTTTT AGAGCGCTTT 420

GATAAAGCCA ATTTGAAAGA AAAATCGCTC ATGCTAGAGA GCTTGAAAAA AAGCAAGAAC 480

ACCGCTATCG CTTTGGAATT GAAAAAGAAA GACAAAAAGT CGCTTAAAAA AGTGTATAAA 540

GAAGAAGTGA TCAAA 555

(2) INFORMATION FOR SEQ ID NO: 85:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 315 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM- Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...315

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 85:

GCGCAAATCT TTGTGCGTTT CAATTATGTT TTAGGCGCGA TCGGTTTTGT GGTGTTACTT 60

TATGAAATCA TTTCGTTTAT CTACTATAAA AGATCGTTAG TGTATTTGAT CCTTGGCGTG 120

GCGATAGGGG CGTTGTGTTT GCTCTTTGTT TTTTATTACA CGCCTTATAT TTTAAACGCT 180

CAAAAGGTGG GTGAAGTTGC GCTTCAAAGT GCTGAATTTG CCCGCTCGCA CGCTCAAAGC 240

GAATGGCTGT TTAAGGAATT GTTTGTGCTG GTGTGTGCTT TGTTTTTTTG GCGTTTGTTT 300

GGGAAAAATG CGCTT 315

(2) INFORMATION FOR SEQ ID NO: 86:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 348 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...348

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 86:

AAGGCTTGCA AGATGAAGTG CTCAAGCTTT ACCTCTAATA GCGTCTTAAA CTTTTTTGTA 60

GTTTTGTCTT TCATCACGAT AGGGCTAGTG TTTTTCTTTT TGCGTTCCCA ACCAACTAGC 120

GTAGTTTCTA AAGAAAATAT CCCTAAAATT GAATTAGAAA ATTTTAAAGC GTTTCAAATC 180

AACGATAAAA TCCTTGATCT GTCCATAGAG GGCAAAAAAG CCCTACAATA CGATGATCAT 240

GAAATCTTTT TTGATTCTAA AATCAAGCGC TATGATGAAG ACACCATTGA AAGCGTTGAG 300

TCCCCTGAAG CCAAACGGCA GCAGGATTTG TATTTCTTCC CTAACGGG 348

(2) INFORMATION FOR SEQ ID NO: 87:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 315 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic) (m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...315

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 87:

AATCAAACAA AGCCAGAAAG AAAAGAAAAA ATTCCCCACT TTCAAAGGAG GGTTTTAATG 60

CGTTGGTGGT GTTTTTTGGT GTGTTGTTTG AGCGTTTTAA GCGTGATGGA CGCTAAAAAA 120

TTAGAGAATA AAGGCTTGAA AAAAGAAAGA GAGCTTTTAG AAATTACCGG CAACCAATTT 180

GTAGCGAACG ACAAAACCAA AACCGCCGTT ATTCAAGGCA ATGTGCAGAT CAAAAAAGGT 240

AAAGACCGGT TGTTTGCGGA TAAAGTGAGC GTGTTTTTAA ACGATAAACG AAAGCCAGAA 300

CGCTATGAAG CAGCA 315

(2) INFORMATION FOR SEQ ID NO: 88:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 957 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...957

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 88:

AAAGAAAGTA ATTCTATGGA CTTAGACAAA CTCAAAGATT ATAGGGCTTT AAGAAACGCT 60

ATTTTAAGGC TATTGCCTTA TTTAGATAGC GGTATTACAG AGCTAATTAT GAATAAAGAA 120

AAAGAAATTT GGCTCTATAA GCTTAATGGA GTAAGAGAAA AAGTCTTTGA TGAAAATTTA 180

GACAAAGCCT TTATTCTGGG GTTTGGGGAA CAATTAGCGA GTTTTAGAGA TTTGTTTTTT 240

AATGCTAATT ACCCCACCCT TAATACTTCC ATTCCTACTT CTAGATACAG AGTGAGCATG 300

AACCACTTTG CTATTAGTGC GGATAATGAA TTGAGTTTGA ATATTAGAGT GCCAAGTGAT 360

AAAAAGTTTG ATTTAAAAGC TTTCAAGCTT TCTAGTATCT GTCAATACGA TTATGAGTAT 420

TTAAAAAACT TAATGATTGA TGGCAAAAAC TTACTCATTA GTGGAGGCAC AGGCAGTGGA 480

AAAACGAGTT TTTTAAACGC TCTAATTGAG TTTATCCCCA AACACACACG AATAGTAAGC 540

GTTGAAGATA GCGAAGAATT AGATTTAAGA GCGTTTGAAA ATCATAAATC CTTGTTAGTG 600

GATAAAACTG AAAGCTCTAA ATTTACATAT GAAAACGCCT TGAATATGGC AATGAGAATG 660

TCTCCTGATA GGCTTATGGT AGGCGAGATT GACACACGAA ATTCCATGCT CTTTTTAAGA 720

TTTGGAAACA CTGGGCATAA AGGCATGGTT TCTACTTTAC ATGCAGATAG TGTGCATGGG 780 GTTATAGAGG CGATTGCTTT AAATTTACAA ATGAATAAAA GTGGTTTAGA TGTCAATGTA 840 GCAAAAAAAT TCTTTAAAAG CAGTGTGGAT GTTGTCGTTC AAATTGTATT AGATAAAGCC 900 ACTAACACCA GATACATTCA AGAAATCTTA CCAGCAAAAG ATTTAAGAGA TAGTCTA 957

(2) INFORMATION FOR SEQ ID NO: 89:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH. 261 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...261

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 89:

GGAGTTAAAG CAATGAATTA CGATGTTTTA ATGGGATTTT TAGCACTAAT CTTGCTAATT 60

CTTTGGTATG CCTATGGATT AAGGCAATAT CTTAAATTAA AAGATAAGAA TAAGAGATTA 120

AAAGAGAAAT TACAACGCTG TAATTGTAAT ATTAAAATTC CTAGTATTCT TGAAATGGCG 180

CATAAACCTA TCATTATGGA TATTAAGGGG GAATTGCTAC CACATCTTAC AGAGAGTTAT 240

AGAAAATCAA AATTTAAGGA G 261

(2) INFORMATION FOR SEQ ID NO: 90:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 285 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...285

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 90: CTCTCAAGGA ATGGCGTGGT CTCTAGCGTG AGTTCTGATG GCTCTAAAAT TTTAATGTCT 60 TTAGCCCCTG ATGGCCAACC GGATGTTTAT TTGTATGACA CGCATAAAAA AACTAAAACC 120

AAAATAACGC GCTATCCGGG GATAGATGTT TCAGGCGTGT TTTTAGAAGA TGACAAGTCT 180

ATGGCTTTTG TTTCAGATAG ATCCGGTTAT CCTAACATCT ATATGAAGAA ATTGGGGTTA 240

AAAGAGAGGC GGAGCAACTC CTTTATGAAG GAAGAAGCAA TGAAT 285

(2) INFORMATION FOR SEQ ID NO: 91:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 438 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...438

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 91:

GGGGATAAAA TGCTAAAAAA GTTATTGCTC ATTTCACTAT TTTTAGGGTT TTTAAGAGCA 60

GAGGGCGAAC ATTATGAAAT CATCGCTGAA CTTTCCAAGG CTTTTTTGAA AGCCAAAGAG 120

GTTTTGACTG CGATCAATAA AACCTATAAA ACCTGTATTG AAACCGGGCA TGATCGCACT 180

CAAATACGCC TTCAAAACGA TTTTTTAGAG AATTTGTCTC AAACAGAGCA ACAATTTGAT 240

GATTATTTTG AAAAGGATTT TAAAAGCGTA GGGGTTTTAA AAACCTTGCT TAAAGACATC 300

CAATCCTTAG AAAAAACTTC CAACAAGCTC GTATGCGTTG CCCCAAAAAA CGCTAAAAAT 360

TTTGAAATAT TAGAGGGAGC GATAACGCAA ATCATAGGAT TAGAAGAGCA GATGAATCAA 420

TTTATCAATG GCGCGAAA 438

(2) INFORMATION FOR SEQ ID NO: 92:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH. 345 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...345 (xi) SEQUENCE DESCRIPTION. SEQ ID NO 92:

ATCCAAAGGC TAAAAGAAAT GCTTAGAAAT CAATTTCGTA TCGTGTTTGT CACCTGCAT 60

GTCGCTAGC GTTTGCAAGC TCAAGAAAAT ACCCCCACTT TGGGTAAGGT AACCACTAAG 120

GGTGAAAGGA CTTTTGAATA CAACCATCAA ATGTATACTG ACAGGAAAGA GCTCCAACAA 180

CGCCAAAGTA ACCAAACCCG TGATATTTTT AGGACTAGGG CGGATGTGAA TGCGGCCAGT 240

GGGGGCTTAA TGGCGCAAAA AATCTATGCC AGGGGGATTG AGAGCCGTCT CTTAAGGGTA 300

ACGATAGATG GCGTCGCTCA AAATGGTAAC ATTTTCCACC ATGAC 345

(2) INFORMATION FOR SEQ ID NO.93:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 792 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...792

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 93:

GCGGTAAGTT GGATAATGGC GTGTTGGCAT AAAAGATTGG CAGTTGGTTG TTGTATCGTT 60

TTATTGTCAT GCGTAATGAG TGCTAATAAT GTTAGTATCG TTAGAGACGA TCCGCCCCTT 120

GATCCAACGC TCCCTGCATG GATTTATTCT GTTGCGTTAT TGAAAGTGTA TTTTAGCGAT 180

GGGACTTATA AAGAAGGCTA TGCGACTTTG CTAGAAAACG GGCGTTATAT CGCTTCTTCT 240

GAAACGCTCT ATTCTAATGG CTTGTATCCT AAAATGATTT TAGCCAAAAT GCAAGACAGC 300

AGTGCTAAAG AGCTGATTTG CATAGCCAGC TTGCACCTTG AAGCGATGGA TAGGGATCAA 360

GGGCTTTCGC TCTTAAAAAC CGCCGATTTT AGAGACGATT ATTGTCATAA AAGAGAAGAG 420

AGCTATTATC ATGCAAGGAT TTATGCCAAA TACGCTCAAA CTTTCCATTC AAATCCTTAT 480

ACCAATCAAA AAACACCCAC TTCCGATCTC TACTACCCGG CGTTAAATGA GGGGAATTCT 540

TTTTCCATAC AGACAACGGA CATTTCTGTG GCTGAACTTT TGAAATCTAA AAAGTTTCTT 600

TCGCTTGATG CTTCTTTTAA AAAGGGGAGC GTGTTGTGGG GAGGGAGACC TTATTTTAGC 660

GAGGTAGGGG AGTTTATGGG AATGACTAGC AGCACTTTAG AAAACCAAGA AAGTTTGGTG 720

ATTATCCCTA AAGAAAAGAT TGCGCGATTT TTAAGCGCTC TAAAAAATCA AAATATTTTT 780

CCAAACATTC CC 792

(2) INFORMATION FOR SEQ ID NO: 94:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 441 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic) (ill) HYPOTHETICAL- NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE.

(A) ORGANISM. Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...441

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 94:

CTTGGAGGAC TAGACATGTA TAAATTAGGA ATATTTTTAT TAGCCACCTT ACTATCAGCT 60

AACACGCAAA AAGTGAGCGA TATTGCTAAA GACATCCAAC ATAAAGAAAC CCTTTTGAAA 120

AAAACCCATG AAGAAAAAAA CCAACTGAAC AGTCGTTTGA GTTCTTTAGG CGAAGCGATC 180

CGCTCTAAAG AGCTTCAAAA GGTTGAGATT GAACGCCAAA TGGTCGCCTT AAAAAAGAGT 240

CTTGAAAAAA ATCGTAACGA AAGTTTGGTG CAAGAAAAAG TCCTAACCAA CTACCGCAAG 300

TCTTTAGATC ATTTGCAAAA ACAACGATCG TTTTTACAAA AGAGAGTGTT TGATACGCTT 360

TTAGAGGATT TTCTTTTCTC ACAAGCCCTA AAGGGGCAGA ATTTAGCCTC TTCTAATGAT 420

GTGATTTTGC TAAGTGGCGT T 441

(2) INFORMATION FOR SEQ ID NO: 95:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1569 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...1569

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 95:

TATATTCCAT TCAATTTATT TCAAGGACAA ACAAACATGA AAAAACTTCT TTATACCATG 60

CTCGCGCTTC TTTTAATCGG CCTTTTAACG GCCTATCTTA TCCTTTTTAC AGAATGGGGG 120

AATAAGATCA TCGCTTCGTA TATAGAGAAA AAAATCAATC CGAACGAGCG TTATTTGAGC 180

GTTAAAACCT TTAAATTGAG ATTCAACTCT TTGGATTTCA AAGCTCAAGC CAACGATGAT 240

TCCACGCTCA TTCTTAAGGG GGATTTCTCG CTTTTAACGC AAAGCGTAAA TTTGGATTAC 300

CACATAGACA TTAAAAATTT ACGCTCTTTT AAGGATTTGA TACCCTACCC CTTAAGAGGG 360

GCTATTGTTA CTTCTGGGAA TATCAAAGGG CATAGAAAAG CCCTTGTAGT TCAAGGCGTC 420

TCCAATGTCG CTCAATCCCA CACTGCCTAC AACGCCCTTT TAGATGATTT CAAGCTTTCT 480

CACTTAAGTT TGAACGCAAA AGACGCCAAT TTAGAAGATT TGCTTTATTT AATCAACCGC 540

CCCGCTTATG CGAACGCAAA AGTGTCCTTA CAAGCGGATT TTAACTCTCT AAAGCCCTTA 600

GAAGGGCATT TGATCCTAAC AGCTAATAAC GCTTTAATCA ATAACGCCCT AATCAATCAA 660 ATCTTTCATT TAAACCTTAA AGACACGCTC GTTTTCAACC TCTCGCACTC AAGCGATTTT 720

AAAGGAAACA AAGCCATCAG CGATACCACC CTAACTAGCC CTTTAGTTAA TTTCACAGCC 780

CTAAAAAGCG AATATTCTTT CCCTGCTTTA AAACTCAACG CCCCCTACAC TTTAGAAATA 840

CCCCATCTAG CCAAACTCCA AAACATTACC AACCACCCCT TAAAAGGGAG CTTGACTTTA 900

AAAGGCGATA TAGAGCAAAG CCCTAAACTC TTAAAAGTCA GTGGCCATTC AAATTTACTA 960

GACGGCGCGC TAGACTTCAC GCTTTTAAAT AAAGATTTGA AAGCCCGTTT TTCCAATATT 1020

TCCACTTCAA AAGCCTTAGA TTTATTCCAT TACCCTAAAT TTTTCCAATC CATTGCAGAC 1080

GCTAACTTGG ATTATGACCT TATCTCTAAG CAAGGCGTGT TGAAAGCCAA TCTCAAGAAC 1140

GCAAGATTCC TCAAAAATGC ATTCAGCGAT TTCCTCTATT CCATTTCTCG TTTTGATATT 1200

ACTAAAGAAA TTTATCACGA TGCCAATCTA GTAAGCCAAA TCAACCAGCA ACGCCTGCTC 1260

TCTGATTTGA GTTTAAAAAG CCCCAAAACC CAATTGAAAA TCCATAACGG CTTGTTGGAT 1320

TTAAACACCA AGCAAATGGA CATACTCATG GATGCGGAAA TCTTAAAATT CATCTTTAAA 1380

ATGAAACTTC AAGGCAGCAT GCACCAGCCA AAATTTTCCC TCATTTTAAA CGAAAAAGCC 1440

ATTCAGCAAA ACCTGCAACA AGGCTTGAAA GAAATCCTTA AAAACGACAC CCTTAAAAAA 1500

GGTTTAGATC ATTTGCTTAA AGATGATAAA CTCAAAGAAA AGCTTGAAAA AGGGCTTAAG 1560

GGGCTTTTT 1569

(2) INFORMATION FOR SEQ ID NO: 96:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 666 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...666

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 96:

GCATTTCTTT ATATTCATTC AATAGCGCTT GCGCGGGTAA TTCTTCAACT AAAACCTCTA 60

CTAACAATTC ATCTGAATGC AAAATCTCAA TCCTCCCTAA AAAACAAAAT CACTCTTAAG 120

AATAAGCTAA ATCATGCTAG AATTATACTT GAATTTATTC CTAGTTTAAT TTATTTCTTA 180

ATACAAAAGG TGAGCGTTTT GAAACATTTA GCCCCACTCA TTCATATCCC TTTTAAAGCC 240

TTATGGCTAG GCACAGCCTT AAGCATGTTC TTAAGTTTGA ATTTGAACGC TGAAGAAAAC 300

CCTACTAAAA CAGAGCCTAA GCCCGCTAAA GGGGTTAAAA ACAAGCCCAA ATCGCCTGTT 360

ACTAATGTCA TGATGACCAA TTGCGATAAC CTTAAAGACT TTAACGCTAA GCAAAAAGAA 420

GTTTTAAAAG CCGCTTATCA ATTCGGATCT ACAGAAAATT TAGGCTATGA AATGGCGGGC 480

ATTGCGTGGA AAGAATCATG CGCAGGGACT TATAAAATCA ATTTTTCGAA TCCGAGTGCG 540

GGCATTTACC ATGCGTATAT CCCTAGCGTT TTAAAAAGCT ATGGGCATAA TAATAGCCCC 600

TTTTTGCGTA ACGTGATGGG GAGAATTGCT ACATTAAAGA CGATGCGTTT GCTTCTGAAG 660

TGGCCC 666

(2) INFORMATION FOR SEQ ID NO: 97:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 897 base pairs (B) TYPE nucleic acid

(C) STRANDEDNESS. double

(D) TOPOLOGY- circular

(11) MOLECULE TYPE DNA (genomic)

(m) HYPOTHETICAL. NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY. mιsc_feature

(B) LOCATION 1...897

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 97:

TTAGTTATAA TATCGCTACT AACAACACTC AAGCTAAAAT CCATTAAGGA AATCAGTATT 60

AAAAAATTTA TTCTATCTTC TCTTGTTTTC GCATGTATCA ATACCGGCGT TGAAGCTTTA 120

GAAAATGACG GCTCTAAACC AAACGATTTG GCTTCTCCAA AAGAAACCCC AAAAGAGGCT 180

CAAAAAAATG AAGCTCAAAA CGAAACCTCT CAATCCAATC AAACGCCTAA AGAAATGAAA 240

GTCAAGTCCA TTTCTTATGT CGGGCTTTCT TACATGTCTG ACATGCTCGC TAATGAAATT 300

GCAAAGATTC GCGTGGGCGA TATGGTGGAT TCTAAAAAAA TAGACACCGC TGTTTTAGCT 360

TTGTTCAACC AAGGGTATTT TAAAGACGTT TATGCCACTT TTGAAAACGG CATTTTAGAG 420

TTTCATTTTG ATGAAAAAGC CAGGATTGCC GGGGTAGAAA TCAAGGGTTA TGGGACTGAA 480

AAGGAAAAAG ACGGCTTAAA ATCCCAAATG GGGATCAAAA AGGGCGACAC CTTTGATGAG 540

CAAAAATTAG AGCATGCTAA AACGGCTTTA AAAACGGCTT TAGAGGGGCA GGGCTATTAT 600

GGGAGCGTGG TGGAGGTGCG CACAGAAAAG GTCAGTGAGG GAGCGTTATT GATCGTGTTT 660

GATGTGAATA GGGGGGACAG TATTTATATC AAACAATCCA TTTATGAGGG AAGCGATAAA 720

TTAAAACGCC GTGTGATTGA ATCTTTGAGC GCGAACAAGC AGCGCGATTT CATGGGCTGG 780

ATGTGGGGCT TGAATGACGG GAAATTGCGC TTAGATCAAT TAGAATACGA TTCTTTGCGT 840

ATCCAAGATG TGTATATGCG TAGGGGTTAC TTAGACGCTC ATATTTCTTC GCCTTTT 897

(2) INFORMATION FOR SEQ ID NO: 98:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 864 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...864

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 98: GAGTTTGGTG TGAAGCGAAT TTTATTTTTT TTAGCGGCTA CGACTTTTTT GTTGAGAGCA 60

GAAACGGCTT CTGCTACTAT TAACACTACA GTTGATCCCA ATGTTATGTT TTCTGAAAGC 120

TCCACAGGGA ATGTGAAAAA AGACCGCAAG AGGGTTTTAA AGAGCATGGT TGATTTAGAA 180

AAAGAGCGCG TGAAGAATTT TAACCAGTAT TCTGAAACCA AGATGAGTAA GGGCGATTTA 240

TCCGCTTTTG GAGCTTTCTT TAAGGGGAGT TTGGAAGATT GCGTGGAGCA AAAGATTTGT 300

TACTATGAGC ATAGGAATGG CAAGGTTTCT TTTGTGGTGA ATGACAGAGA AAAGTTTTAT 360

AAGCATGTGC TTAAAGACTT AGGGACAGAG CTTTCACTCC CCTTGTTCAA CTGGCTTTAC 420

AAAGGCTCAG ATTTTGGGGC TTTGCATGAG CAGTTTGGGG ACATGTATGA TGGGTATATC 480

AAATACTTGA TCAGCATGGT TAGGGTGAGC CAAAAAGAAA AGGCTAGAAA AGTGGATGCA 540

ATCGTTCTTA AAAAAATGGA AGAACAAGCT GAGAAAGACA CTAAGGCAGC ATTCCAAAAG 600

AGGAGCAGTG GGGAGCTTGA AAGCCATACT GATAGCCCTG AATTTATAAG CTCTTCTAAG 660

ACACAGAATT CTTCTAACCC AGATCTAGAC CCTATGACTA ACGCTAACAC GCTCAAAGAA 720

ACAGCTTCAA AAGAGCCAGA GACTTCTTCA AAAAAGGAAA AAAAGCCCAA GAAAAAACGA 780

CGCCTTTCAA AGAAAGAAAA GCAACAACAG GCCTTACAAC AAGAGTTTGA AAAGCAAATT 840

AGCGACTCTA GTAAGTCTGA AAAA 864

(2) INFORMATION FOR SEQ ID NO: 99:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1221 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1221

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 99:

AGTCGCACCC TTTGTGCAAA AATCGTTTTA CAAAAAGAAA GGAAGAAAAT GGAAATACAA 60

CAAACACACC GCAAAATCAA TCGCCCTTTA GTTTCTCTCG TTTTAGCAGG AGCGTTGATT 120

AGCGCCATAC CGCAAGAGAG TCATGCCGCC TTTTTCACGA CCGTGATCAT TCCAGCCATT 180

GTTGGGGGTA TCGCCACAGG CACTGCTGTA GGAACGGTCT CAGGGCTTCT TAGTTGGGGA 240

CTCAAACAAG CCGAAGAAGC GAATAAAACC CCAGATAAAC CCGATAAAGT TTGGCGCATT 300

CAAGCAGGAA AAGGCTTTAA TGAATTTCCT AACAAGGAAT ACGACTTATA CAAATCCCTT 360

TTATCCAGTA AGATTGATGG AGGTTGGGAC TGGGGGAACG CCGCTAGGCA TTATTGGGTC 420

AAAGGCGGGC AATGGAACAA GCTTGAAGTG GATATGAAAG ACGCTGTAGG GACTTATAAA 480

CTATCAGGGC TTAGAAACTT TACTGGTGGG GATTTAGACG TGAATATGCA AAAAGCCACT 540

TTGCGTTTGG GCCAATTCAA TGGCAATTCT TTCACAAGCT ATAAGGATAG CGCTGATCGC 600

ACCACGAGAG TGAATTTCAA CGCTAAAAAT ATTTCAATTG ATAATTTTGT AGAAATCAAT 660

AATCGTGTGG GTTCTGGAGC CGGGAGAAAA GCCAGCTCTA CGGTTTTGAC TTTGCAAGCT 720

TCAGAAGGGA TCACTAGCAG TAAAAATGCG GAAATTTCTC TTTATGATGG CGCCACGCTC 780

AATTTGGCTT CAAACAGCGT TAAATTAAAT GGTAATGTGT GGATGGGCCG TTTGCAATAC 840

GTGGGAGCGT ATTTAGCCCC TTCATACAGC ACGATCAACA CTTCAAAAGT TCAAGGGGAA 900

GTGGATTTTA ACCATCTCAC TGTGGGGGAT CAAAACGCCG CTCAAGCGGG CATTATCGCT 960

AGCAATAAGA CTCATATTGG CACACTGGAT TTGTGGCAAA GCGCCGGGTT AAATATCATT 1020 GCCCCTCCAG AAGGTGGCTA CAAGGATAAA CCTAATAGTA CCACTTCTCA AAGTGGCACT 1080

AAAAACGACA AGAAAGAGAT CAGTCAAAAT AACAATAGCA ACACAGAGGT CATTAACCCA 1140

CCCAATAACA CGCAAAAAAC AGAAACTGAA CCCACCAAGT CATTGATGGG CCTTTTGCTG 1200

AAGGCAAAGA CTCGGTTGTC A 1221

(2) INFORMATION FOR SEQ ID NO: 100:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 489 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...489

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 100:

CAAATCTTTT GCTCCACGCA ATCTTCCAAA CTCCCCTTAA AGAAAGCTCC AAAAGCGGAT 60

AAATCGCCCT TACTCATCTT GGTTTCAGAA TACTGGTTAA AATTCTTCAC GCGCTCTTTT 120

TCTAAATCAA CCATGCTCTT TAAAACCCTC TTGCGGTCTT TTTTCACATT CCCTGTGGAG 180

CTTTCAGAAA ACATAACATT GGGATCAACT GTAGTGTTAA TAGTAGCAGA AGCCGTTTCT 240

GCTCTCAACA AAAAAGTCGT AGCCGCTAAA AAAAATAAAA TTCGCTTCAC ACCAAACTCC 300

TATATCCATA ACCGCAACAA AAACAGACGC TATTCTTCAT TAAGCCCTCT TTTAAAATCT 360

TCTTCTATTT GTAAAAACCC ACCTAGAATT CAAGCTATTT TGATTATCTT AAAATACAGA 420

CTTTCAAAGG GTTTTAATCC TGTGGTGGTG ATACTTAGGA TCCAAAAAAT GCGGACTCTC 480

CAAAAACTT 489

(2) INFORMATION FOR SEQ ID NO: 101:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 603 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature (B) LOCATION 1...603

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 101:

GGTTTAATCA CAATGGATAA AAACAACAAT AATAATCTCC GCTTGATTTT AGCGATCGCT 60

CTGTCTTTCT TGTTAATCGC TCTTAATAGC TATTTTTTCC AAGAACCAAA CAAAACAACA 120

ACCGAAACCA CAAAGCAAGA AACAACCAAC AACCACACAG CAACAAGCCC CACCGCGTCC 180

AATACCATCA CCCAAGATTT TAGCGTTACC CAAACCATCC CTCAAGAGAG TTTGTTAAGC 240

ACGATTTCTT TTGAACATGC CAAAATTGAA ATTGATTCTT TAGGGCGCAT CAAACAGGTT 300

TATCTCAAAG ATAAAAAGTA TCTAACCCCT AAAGAAAAGG GCTTTTTAGA GCATGTGAGC 360

CATCTTTTTA GCTCCAAAGA AAACTCGCAA CCCTCCCTAA AAGAGCTCCC CCTTTTAGCA 420

GCCGATAAAC TCAAGCCTTT AGAAGTGCGT TTTTTAGACC CCACGCTCAA TAATAAAGCG 480

TTCAACACCC CTTATAGCGC CTCAAAAACC ACCCTTGGGC CTAACGAACA GCTCGTTTTA 540

ACCCAAGATT TAGGCACTCT TAGCATCATT AAAACCCTGA CTTTTTATGA TGATTTGCAT 600

TAT 603

(2) INFORMATION FOR SEQ ID NO: 102:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 204 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...204

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 102:

GGAGTTTCTA TCATTATGGT ATTGAAAACA AAATTAAAAA TTATAAGCTC GGTGATTTTG 60

AGTACTTTAT TGTGGGTGGG TTGCTCAAGC GAAATGGCGA CTTATCAAAA TGTGAATGAC 120

GCCACTAAAA ATACGACTGC AAGTATTAAT AGCACGGATT TATTGCTAAC CGCTAACGCG 180

ATGTTAGATT CCATGTTAGG GACC 204

(2) INFORMATION FOR SEQ ID NO: 103:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 528 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI -SENSE: NO (vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...528

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 103:

GCGATGAAAA ATCAAGTTAA AAAAATTTTA GGGATGAGTG TGGTAGCAGC GATGGTGATC 60

GTAGGTTGTA GCCATGCCCC AAAATCAGGT ATCAGTAAAA GCAATAAGGC ATACAAAGAA 120

GCGACTAAAG GCGCTCCTGA TTGGGTTGTA GGGGATTTGG AAAAAGTGGC GAAGTATGAA 180

AAATATTCAG GGGTCTTTTT AGGAAGGGCT GAAGATTTGA TCACTAATAA TGATGTGGAT 240

TATTCTACGA ATCAGGCTAC AGCCAAAGCT AGGGCTAATT TAGCGGCGAA TCTAAAGTCC 300

ACTTTACAAA AAGATTTGGA AAATGAAAAA ACCAGAACGG TAGATGCTTC TGGTAAAAGG 360

TCCATAAGCG GCACTGATAC TGAAAAAATT TCTCAATTAG TGGATAAGGA ATTGATCACT 420

TCTAAAATGC TTGCCCGCTA TGTCGGTAAA GATAGGGTTT TTGTTTTAGT GGGCTTGGAT 480

AAGCAAATTG TGGATAAAGT GCGCGAAGAG TTAGGCATGG TTAAAAAG 528

(2) INFORMATION FOR SEQ ID NO: 104:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 300 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...300

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 104:

CCCAAACCTT ACGCCGTCAG TATTCTATGT ATTTGCGTTA TGTTTATACT TTTTAAGTTT 60

GGTAGGGTTT TGGGTAAGGC TTATAGCTTA TACTTATATA TATATGAAAG CTTGATTTGT 120

CAAGCTTTTG GGTTGTCATT GAGTTGCAAT AACTCTATGC TGTTTTCTAC TTTTTTGATA 180

AATCTACCAT TACCACACAA TGAGTCCTTA TGCTGTTGTA GGGATATTTT AGCGTATTCT 240

AACTCTTCAT CGCTAAAGAC ATATTCATTG GAGTCAAATT TTTCTTTCAA TTCTTTATTT 300

(2) INFORMATION FOR SEQ ID NO: 105:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 300 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular (11) MOLECULE TYPE- DNA (genomic)

(111) HYPOTHETICAL- NO

(iv) ANTI-SENSE NO

(vi) ORIGINAL SOURCE.

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...300

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 105:

ACAGCAAGAA TGAATCGCAT GAAACCAATT TTTTTGTTAA TCTTTTTGTT GTTAGCGAGC 60

CTTATTGCTA GAGAAAAGGA CGCTTCTTCA AACCTTTTTG ATTTGATCGA TAAGGGGATT 120

AACAGAGAAC AAGAATTGAA AGAGCAGGAG CAAAAAACGC GCTTGAAACT GGCTCAAAGC 180

CCTTTAGTGG CGTTAGAAAT TGTCCCCCAA GAAACGCCCT ATTTAGAATG GCAAGGGGCT 240

AGGGAGTCGT ATTATTTGAA AGTAGAGCGC TGTAGTGGAG AGCGTGGTTA TTTTAAAGAT 300

(2) INFORMATION FOR SEQ ID NO: 106:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 693 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...693

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 106:

GTTGCTCGCG CTTTTATCGC TCTTTATGCC ATTTCAGCGG TCAATAAATC CAAAGTGGAA 60

GCCTTAAAAA CCGAATTTAT TAAGATTTTT AATTACGCCC CAAAGCCAGA GGCGATGCAG 120

CCGGTTGTAG TGATCCCCCC TGATTCAGGG AAAGAAGAAG AGCAAATGGC GAGCGAAAGC 180

TCCAAGCCGG CTTCGCAAAA TACCGAAACA AAAGCCACTA TCGCTCGCAA GGGCGAAGGC 240

AGTGTTTTAG AGCAAATTGA TCAAGGCTCT GTTTTAAAGC TCCCCTCTAG TTTGCTGTTT 300

GAAAACGCCA CTTCAGACGC TATCAATCAA GACATGATGC TTTATATTGA ACGGATCGCT 360

AAAATCATTC AAAAACTCCC TAAAAGGGTG CATATTAATG TGAGAGGTTT TACGGATAAC 420

ACGCCTTTAA ATAAAACCCG TTTTAAAAGC CACTATGAAT TAGCCGCCAA TCGCGCTTAT 480

AGGGTGATGA AAGTCCTTAT ACAATACGGC GTGGATCCTA ACCAATTGTC TTTTTCTTCT 540

TACGGCTCTA CCAACCCTAT TGCGCCCAAT GATTCCCTAG AAAACAGAAT GAAAAACAAT 600

CGTGTGGAAA TCTTTTTTTC AACCGATGCG AACGATTTGA GCAAGATCCA TTCTATTTTA 660

GATGAAGAAT TCAATCCCCA TAAACAGCAA GAA 693 (2) INFORMATION FOR SEQ ID NO- 107-

(l) SEQUENCE CHARACTERISTICS.

(A) LENGTH. 294 base pairs

(B) TYPE nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY, circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...294

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 107:

CAGCGTCTAT ACCTAGGAAA ATTAAACGCT AAAGTGAATC ACACGATTTT CCAATTTTTA 60

GTGAATGTGG GCATTAGAAC CAATATTTTT GAACACCATG GCATTGAGTT TGGTATCAAA 120

ATCCCCACGC TCCCTAATTA CTTTTTCAAA GGTTCTACTA CTATAAGAGC GAAAAAACAA 180

GGCCCACTAG AGAATGGGAA CCCGACTACT ATCACCGGAG CAGAAACCAA TTTCAGCTTA 240

ACCCAAACCT TACGCCGTCA GTATTCTATG TATTTGCGTT ATGTTTATAC TTTT 294

(2) INFORMATION FOR SEQ ID NO: 108:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1071 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(lV) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...1071

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 108:

TTTCATTTTT ACTGCTTGTA TTTCCTTAAT GGTGGTTATA ATCGGCTTCA TAAATCATAC 60

GAAAGGATTG TCATGCTAAT CGCTCGCTTT AAAAAAGCTT TAATTTCCTA TTCTTTAGGG 120

GTTCTTCTTG TTTCATCGTT ATTAGGCGTG GCTAACGCTT CTAATCAAGA GATCCAAGTC 180

AAGGATTATT TTGGGGAGCA AACCATAAAG CTTCCTGTTT CTAAAATAAT CTACTTGGGC 240

AGCTTTGCAG AAGTGCCTGC CATGTTCAAT ACTTGGGATA GGGTCGTGGG CATTTCGGAT 300 TACGCTTTTA AATCTGATAT TGTTAAAGCC ACTCTCAAAG ATCTTGAACG CATTAAACCC 360

ATGAGCAGTG ATCATGTGGC GGCGTTGAAT GTGGAATTAT TAAAAAAGCT TAGCCCTAAT 420

CTTGTGGTAA CCTTTGTGGG TAACCCTAAA GCGGTAGAGC ATGCGAAAAA ATTTGGGATT 480

TCATTCCTTT CTTTCCAAGA AAAAACCATT GTAGAGGTCA TGGAAGATAT TGACGCTCAA 540

GCTAAGGCCT TAGAAGTTGA CGCTTCTAAA AAATTGGCTA AAATGCAAGA AACTTTGGAT 600

TTTATCAAAG AGCGTTTGAA AAATGTCAAA AAGAAAAAGG GGGTGGAGCT TTTCCATAAA 660

GCCAATAAAA TCAGCGGCCA TCAAGCCCTT GATTCAGACA TTTTAGAAAA AGGGGGTATA 720

GATAATTTTG GCTTGAAATA CGTTAAGTTT GGACGCGCTG ACATTAGTGT GGAAAAAATC 780

GTTAAAGAAA ACCCTGAAAT CATTTTCATT TGGTGGGTAA GCCCACTCAC TCCTGAAGAC 840

GTGTTGAACA ACCCTAAATT TTCCACTATC AAAGCCATTA AAAACAAGCA AGTCTATAAG 900

CTCCCCACAA TGGATATTGG CGGACCTAGA GCCCCACTCA TTAGTCTTTT TATCGCTTTA 960

AAAGCCCACC CTGAAGCGTT TAAGGGCGTG GATATTAATG CGATAATCAA AGATTACTAT 1020

AAAGTGGTCT TTGATTTGAA TGACGCGGAA GTTGAACCCT TTTTGTGGCA C 1071

(2) INFORMATION FOR SEQ ID NO: 109:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 183 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...183

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:109:

GATCATCACA AGGAGTTTCG TATGAAAAAG CAAATCTTGA CAGGTGTTTT GTTATCAGTT 60

TTGGCAGTGA GTTCTGCATA CGCTCACAAA GATAAAAAAG ACGCTAAAAA ACCTGAGTTA 120

AGCTCTCAAT TAGTGGCTCA CAAAGATAAA AAAGACGCCA AAAAACCTAA AAACTCAGTG 180

GCC 183

(2) INFORMATION FOR SEQ ID NO: 110:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 600 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE: ( A ) ORGANI SM : Hel icobac ter pylori

( ix ) FEATURE :

(A) NAME/KEY: misc_feature

(B) LOCATION 1...600

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 110:

AGAATAATAA AAGGAAACAT TATGAGCAGC GGGTTAATTT ACATTTCATT AGAAGTCTTG 60

GTAGCGTGTT TGATCACCGC TCTAATCATG TATTATGTGA TGAAAAAGAT CTATTACGCT 120

AGAGGGCAAG CCATTTTAAA AGGCGCTTCA GCCAAAGCTA AATTAATGGA ATTTCAAGCG 180

AAATCTTTCG TGGAAGCTGA AGAAATGCGC ATGAAAAGCC AAGAATGCAA GTTGCAACAG 240

CAATATGAAA ATAAGAATTT GCAACTCCAA ACCCATTTTG ATAAAAAAGA AGCGCATTTG 300

AAGCATTTAG AAGCGCAGCA CAAAGAATTT GTAAGAGATG AAAAACGCTA TTTGGAAAAG 360

GAAAAAAAAG AGCTTGAAAA AGAACGCCAA ATTTTAGAAC AAGAGAGGGA AAATTTTAAA 420

AAACAGCGCG CCATTTGTAA AGAAGCTCAA GCCAAAGCGC TAGATGCGAT GCTCAATTAC 480

ATGGCTTATA CCAAAGATGA AATTAAAAGC ATGATCTTAG AGCAATTAGA ACAGGAACTA 540

GAAGCGCAAA AGAGCGCCTT GATCAGGCGT TATGAAGAAG AAGCCTTTAT TATGTGTTTA 600

(2) INFORMATION FOR SEQ ID NO: 111:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 501 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...501

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 111:

GGCCGAGCTT TTATGATGCG AGAGATCCTT ACTAACCGCT TTTTCCCAAG CCTTTTTAAA 60

AAAAGGCTTG ATTTTTCTAA CAGAGTGGTT TTAGGGCTGG GATCTAATCT TAAAAACCCT 120

TTAAAAATAT TAAAAAGTTG TTTTTTATAT TTTAAAAATC ATAGTAAAAT CGGGAAAATT 180

TTTTCTTCAC CCATTTATAT CAATCCGCCT TTTGGTTACA CTAATCAACC TAACTTTTAT 240

AACGCTACGA TTATCCTTAA AACATCTTTA GGTTTGCGCC ATTTTTTTGC TCTAGTGTTT 300

TATATAGAAA GGCGTTTTGG GCGTGCAAGG AAGCGCGATT TTAAAGATGC TCCAAGAACT 360

TTAGATATTG ATATTATCGC TTTCAATCAA GTCATTTTGA GGCAGAATGA TTTGACTTTA 420

CCTCACCCTA AATGGAGTGA AAGAGACTCG GTGTTAGTGC CTTTAACTTT ACAACAAATC 480

CTTTTTAAAA GAGAAGAGTG G 501

(2) INFORMATION FOR SEQ ID NO: 112:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 513 base pairs

(B) TYPE: nucleic acid (C) STRANDEDNESS. double

(D) TOPOLOGY, circular

(11) MOLECULE TYPE. DNA (genomic)

(m) HYPOTHETICAL- NO

(iv) ANTI-SENSE- NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...513

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 112:

ATAATAGAAA TTTTAGTGAT TCAAGGGCCT AATTTAAACA TGTTAGGACA CAGAGACCCA 60

AGACTTTATG GCATGGTAAC CTTAGACCAA ATCCATGAAA TCATGCAAAC TTTCGTGAAG 120

CAAGGCAATT TAGATGTGGA ATTAGAGTTT TTTCAAACCA ATTTTGAGGG CGAAATCATT 180

GATAAAATCC AAGAGAGCGT GGGCAGCGAT TATGAGGGGA TTATCATTAA CCCTGGAGCG 240

TTTTCGCACA CTTCTATTGC GATTGCGGAT GCGATCATGC TAGCGGGCAA ACCTGTCATT 300

GAAGTGCATC TCACTAACAT TCAAGCCAGA GAAGAATTCA GGAAAAATTC TTACACCGGA 360

GCGGCTTGTG GAGGCGTGAT CATGGGATTT GGCCCGCTTG GCTACAACAT GGCTTTAATG 420

GCGATGGTCA ATATTTTAGC CGAAATGAAA GCGTTCCAAG AAGCCCAAAA AAACAACCCT 480

AATAACCCCA ATAACCCGAT CAACAATCAA AAA 513

(2) INFORMATION FOR SEQ ID NO: 113:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 198 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

( ll) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...198

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 113:

CCGCGAATCA TAGCATTCTT TTGGATATGG GGATCAAATA CGAACGCTAT TGCTCTGATA 60

GGACTCGCAC GGCTTTTTTT GAACCCTAAA GACTTTGTGT TCAAAAGGGA GCAGAGTTTC 120

AAGGATAAAG AGCGTCAAAA GATTTATGAC ATTGTGAAAG AAGCGCAAGA AAAGGCTATT 180

CAGGCATTAG AGCGGGGA 198

(2) INFORMATION FOR SEQ ID NO: 114: (l) SEQUENCE CHARACTERISTICS-

(A) LENGTH: 210 base pairs

(B) TYPE nucleic ac d

(C) STRANDEDNESS- double

(D) TOPOLOGY: circular

(i ) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...210

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 114:

CGATTATGGC TATGGGCAGT ATTCACTCAC AGCACCGGGC ATGGCATTGA CTTAGACATT 60

CATGAGCTTC CCTATATTTC ATCGCGCAGT GAAACCATTT TAGAAGAGGG CATGGTGTTT 120

TCTGTAGAGC CTGGGATTTA TATCCCTGGG TTTTTTGGGG TGCGCATTGA GGATTTAGTG 180

GTGATTAAAA ATTCTAGGGC CGAGCTTTTA 210

(2) INFORMATION FOR SEQ ID NO: 115:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 297 base pairs

(B) TYPE: nucleic ac d

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(Vl) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...297

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 115:

TACCAATACA TCCAACAAGG CGGGGGCTTT GGGGTGAATG TCGGGCGCAC GCTGGGTAAT 60

AGAACCCATG TGAGCTTAGG GTATAACCTG AATGTTACCA AACTCCTTGG TTTCAGCAGC 120

CCCTTATACA ACCGCTACTA TTCCTCTGTT AATGAAGTGG CCTCTCCAAG GCAATGTTCC 180

ACACCCGCAT CGGTGATTAT CAACCGCTTA TCAGGCGGTA GAACTCCATT GGTTCCTGAA 240

AGCTGTTCTA GTCCTGGAGC GATCACCATC TTCACCAGAA ATAAAAGGTA TTTGGGA 297

(2) INFORMATION FOR SEQ ID NO: 116: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 276 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...276

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 116:

ATGGCGTGTG AATTTTTGAA AAAGCCAAAG TATTACAAGT TTATAGAGGG GGCGAATTAT 60

TTGAGCTTAG GGCTTTCTAT GGTGGTGGCG ATCCTTATGG GCGTGGCTAT AGGCTATGGG 120

CTTAAAAAAC TCACTCACAT TTCGTGGCTT TTTTGGCTTG GGGTTATTTG GGGCGTGTTA 180

GCGAGCTTTC TCAATGTCTA TAAGGCTTAT AAAAACATGC AAAAAGACTA TGAAGAACTA 240

GCCAAAGACC CTAAATACAC GCAAAATAAA ACAAAA 276

(2) INFORMATION FOR SEQ ID NO: 117:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 267 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...267

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 117:

AGGAACTTGA TGAAAACGAC AGAAAACACA GATGAAACTC ACTTAAGGGA AACTAAAAAT 60

AAACTAGGAC GCAAACCAAA AGCAGACGCT AATAAAAAAA CTCGCGCGGT AAGCTTGTAT 120

TTTTCTGATG AGCAATACCA AAAACTAGAG AAAATGGCTA ACGAAGAAGA AGAAAGCGTG 180

GGATCTTATA TCAAACGCTA TATTTTGAAG GCTTTAAGAA AAATAGAACA AGGTGGTGGC 240

TTTATAGCTT TTAACTTGTT TTTAATT 267 (2) INFORMATION FOR SEQ ID NO 118

(l) SEQUENCE CHARACTERISTICS

(A) LENGTH 309 base pairs (3) TYPE nucleic acid

(C) STRANDEDNESS double

(D) TOPOLOGY circular

(n) MOLECULE TYPE DNA (genomic)

(ill) HYPOTHETICAL NO

(iv) ANTI-SENSE NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY- mιsc_feature

(B) LOCATION 1...309

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 118:

ATTTTGAAGG GGGGGTTTTT AGGGTTTTTT ATCGTGGCGT TGTCTTCGTA TTACGGCGTT 60

AAAAAGCGTT TGGATTTGAG GAAACAAGAT TCAAAAGAAA AAGAAGAAAA GCAAAAATTC 120

CAAAAATTCG CCCTAGGTTT GGAAATGTCT TTCAATGTGT GGCGTTTAGG GGGGTATGGG 180

GTTTTATTAG GTATTTTAGG AGTGCTTTTA TTCTTGCATC TTTTTAACGG ATTGCCGTTT 240

CTTATCGGCG TGTTTGTGAG CTCGCTCTCT AGCGCGTTAT TACGATTCTT AAACAATAAT 300

GGTAAGTTT 309

(2) INFORMATION FOR SEQ ID NO: 119:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 771 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL. NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM. Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY. mιsc_feature

(B) LOCATION 1...771

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 119:

GCCCTTACAC CAAATCCCAT GAAACTCCCG GTCGTTGAGA GCTTTTTTTC CTTACAGGGT 60

GAAGGAAAAA GGATAGGCAA GCCCAGTCTT TTTTTGCGCT TAGGGGGGTG TAACCTTTCA 120

TGCAAGGGCT TTAATTGTAA AACCTTATTC AATGATGAAA TCCTAACAGG TTGCGATAGT 180

TTGTATGCGG TGCATCCTAA ATTCAAAACA TCTTGGGATT ATTACAATGA GCCTAAGCCC 240 TTGATTGAAC GATTAGTTAA TTTAGCCCCT AATTATAAGG ATTTTGATTT CATTCTTACA 300

GGCGGGGAGC CAAGCTTGTA TTTTAATAAC CCTATTTTAT TGAGCGTTTT AGAGCATTTT 360

TACCATAAAA AAATCCCTTT ATTTGTAGAG AGTAATGGCT CTATTTTTTT TGAATTTAGC 420

CCTATTTTAA AAGAATTGCA TTTCACCCTA AGCGTCAAAC TCTCTTTTTC TTTGGAGCAA 480

GAAAGCAAGC GGATCAACCT TAAAGCCTTA CAAAATATCT TAAATAACGC TAAAAGCGTG 540

CATTTTAAAT TCGTATTGGA GAGTCAAAAC GCCGCTCATT CTATCGCAGA AATTCAAAGC 600

CTTTTGAAAC AGCTCTCCTT AAAAAATAAT GAAATCTTTT TAATGCCCCT AGGCACAACT 660

AACAACGAGC TAGACAAAAA TCTAAAAACC CTAGCCCCCC TAGCCATAGA GCATGGTTTT 720

AGGCTGAGCG ATAGGCTTCA TATCCGCTTG TGGGACAATA AGAAAGGGTT T 771

(2) INFORMATION FOR SEQ ID NO: 120:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1158 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1158

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 120:

TTCAAGGATC AAGGCATGAA TTTAAACTTT ATGCCCCTAT TGCATGCTTA TAACCATGTA 60

AGCATTGATT TTCATTTCAA TTCTAGCGCT AGGGATTTTT GCGTGCATGA AGTGCCTTTG 120

TATGAATTTA GCAACACGGG CGAACATGCC GTTATTCAAG TGAGAAAAAG CGGTTTAAGC 180

ACTTTAGAAA TGCTTCAAAT TTTTTCTCAA ATTTTAGGGG TAAAAATCGC TGAATTGGGT 240

TATGCGGGCT TGAAAGATAA AAACGCGCTG ACGACTCAAT TCATCTCACT CCCTAAAAAA 300

TACGCCCCTT TATTAGAAAA AAATACGAGC AACTTTCAAG AAAGAAACCT TAAAATCCTG 360

TCTTTGAATT ACCATCACAA TAAAATCAAA TTAGGGCATT TAAAGGGGAA TCGCTTTTTT 420

ATGCGTTTCA AAAAAATGAC CCCCCTAAAC GCTCAAAAAA CGGAGCAAGT TTTAGAACAA 480

ATCGCGCAGT TTGGCATGCC TAATTATTTT GGCTCGCAAC GCTTCGGGAA GTTCAATGAC 540

AACCATAAAG AGGGGTTAAA AATCTTGCAA AATGAAACGA AATTCGCCCA CCAAAAATTA 600

AACGCTTTTT TAATTTCAAG CTATCAAAGT TATTTGTTTA ATTCGCTTTT AAGCAAGCGA 660

TTAGAAATCA GTAAAATCAT TAGCGCTTTT AGCGTCAAAG AAAGTTTAGA ATTTTTTAAA 720

CAAAAAAATT TAAGCGTCCA TTCAAACGCC CTAAAAGCCC TTAAAAACCA AGCCCACCCC 780

TTTAAAATCT TAGAAGGCGA TGTGATGCGC CATTACCCTT ATGGGAAGTT TTTTGACGCT 840

TTGGAATTAG AAAAAGAGAG CGAAAGGTTT TTGAACAAAG AAGCTGTGCC TACGGGGTTA 900

CTGGACGGTA AAAAAGCTCT TTATGCAAAA AATTTGAGTT TAGAAATTGA AAAAGGATTC 960

CAGCATAACC TTTTAAGTGG CCATGCTAAA ACGCTAGGAT CCAGGCGGTT TTTTTGGGTG 1020

TTTGTGGAAA ATATAACTTC TCAATACATC AAAGAAAAAG CGCAATTTGA ATTGGAATTT 1080

TACTTGCCTA AAGGGAGTTA TGCGAGCGCG CTGCTCAAAG AAATCAAGCA TGAGAAAGGA 1140

GAAAATAATG ACGAATTT 1158

(2) INFORMATION FOR SEQ ID NO: 121:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 189 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...189

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 121:

AAGATTAAAG GAAAAGAGAT GAAATTTTTA AACGGATTAG CAGGGAATTT ACTGATTGTG 60

GTTATCTTAT TGTGTGTGGT CGTTTTTTTC GCGCTCAAAG CGATCCATAT CCAAAAAGAG 120

CAAGCCACCA ATTATTACCG CTATAAGGAT ATTAACGCTT TAGAGGCAAA AAACACCCAA 180

AACCACGCT 189

(2) INFORMATION FOR SEQ ID NO: 122:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 300 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...300

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 122:

ATGCTAGAAA TTGAATTAAA AAAGAAATTC ACTAAGGATT TAAAAAAGCA TATTTTAAAT 60

CAAAAAATTG AGTTAGAAGT TTTTGACTTA GTGGTTGAAA ATTTAAGAAA TCAAATTCCA 120

TTGGACAAAA GATTTAAAGA CCATGCTTTA AGTGGAACAT ACAAAGGCTG TAGAGAGCGC 180

CACATTAAGC CTGATGTTTT GCTTGTGTAT AGAGTGAAAG GCAATGTTTT AACTTTGGTT 240

AGGCTTGGCA GTCATAGCGA GCTGTTTTGT AAACCGCCCA CACCACTCAT AACGCTTAAA 300

(2) INFORMATION FOR SEQ ID NO: 123:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1938 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

( ll) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...1938

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 123:

TCGAATTACA ACAACCTAAA CACTCTTGTA TCGCTGTCCT CCGATCCGAG TGCTGTCAAC 60

GACGCAAGGG ATAATCTAGG CTCAAGCGCT AGGAATTTGC TAGATGTCAA AGCCAATTCC 120

CCCGCCTATC AAGCGGTGCT TTTAGCATTG AACGCTGCAG TGGGCTTGTG GCAAGTTACA 180

AGCTATGCCT TTACCGCTTG TGGTCCTGGT AGCAATGAGA ACGCGAATGG AGGTATCCAA 240

ACCTTTAATA ATGTGCCAGG ACAAAACACG ACGACCATCA CTTGTAATTC GTATTATGAG 300

CCAGGACATG GCGGGCCAAT ATCCACTGAA AATTATGCGA TCATCAACAA GGCTTATCAA 360

ATCATTCAAA AGGCTTTGAC AGCCAATGGA GAAGGGATCC CAGTTTTAAG CAACACCACT 420

ACAAAACTTG ATTTCACTAT CAATGGAGAC AAAAGAACGG GTGGCGAACC AAATAAAAAA 480

TTAGTATACC CATGGAGTCA TGGGAAAGCT ATTTCAACCT CGTGGAATGC AACCATAACA 540

GTACCAACAA CAGAAAATAT CAATACAACC AATAGCGCTC AAGAGCTTTT AAAACAAGCG 600

AGCATCATTA TCACTACCCT GAATAGTGCA TGCCCAAACT TCCAAAATGG TGGTAGCGGT 660

TATTGGGCAG GGATAAGTGG CAATGGGACA ATGTGTGGGA TGTTTAAGAA TGAAATCAGC 720

GCTATCCAAG GCATGATCGC TAACGCGCAA GAAGCTGTCG CGCAAGCCAA AATCGTTAGT 780

GAAAACACGC AAAATCAAAA CAGCCTAGAC GCTGGAAAAC CATTCAACCC CTACACAGAC 840

GCTAGTTTTG CTGAAAGCAT GCTCAAAAAC GCGCAAGCCC AAGCGGAGAT TTTAAACCAA 900

GCCGAACAAG TGGTGAAAAA CTTTGAAAAA ATCCCTACAG CCTTTGTAAA TGACTCTTTA 960

GGGGTGTGTT ATGAAGTGCA AGGAGGTGAG CGTCGTGGCA CCAATCCGGG TCAGACGACT 1020

TCTAACACTT GGGGGGCAGG CTGTGCGTAT GTAGGACAAA CGATAACAAA TCTTAAAAAC 1080

AGCATCGCCC ATTTTGGCAC TCAAGAGCAG CAGATACAGC AAGCCGAAAA CATCGCTGAC 1140

ACTCTGGTGA ATTTCAAATC TAGATACAGC GAATTGGGCA ACACTTATAA CAGCATCACC 1200

ACTGCGCTCT CTAATATCCC TAACGCGCAA AGCTTGCAAA ATGCGGTGAG TAAAAAGAAT 1260

AACCCCTATA GCCCGCAAGG CATAGACACC AATTACTACC TCAATCAAAA CTCTTACAAC 1320

CAAATCCAAA CCATCAACCA AGAACTCGGG CGTAACCCCT TTAGGAAAGT GGGGATTGTT 1380

AGTTCTCAAA CCAATAATGG CGCGATGAAT GGGATCGGTA TTCAGGTGGG TTACAAACAA 1440

TTCTTTGGCC AAAAAAGAAA ATGGGGCGCT AGGTATTACG GCTTTTTTGA TTACAACCAT 1500

GCGTTCATTA AATCCAGCTT CTTCAACTCG GCTTCTGACG TGTGGACTTA TGGCTTTGGA 1560

GCGGACGCTC TTTATAATTT CATCAACGAT AAAGCCACCA ATTTCTTAGG CAAAAACAAC 1620

AAGCTTTCTG TGGGGCTTTT TGGGGGTATT GCATTAGCCG GGACTTCATG GCTTAATTCT 1680

GAGTATGTGA ATTTAGCCAC CATGAATAAC GTCTATAACG CTAAAATGAA CGTGGCGAAT 1740

TTCCAATTCT TATTCAACAT GGGAGTGAGG ATGAATTTAG CCAGGCCTAA GAAAAAAGAC 1800

AGCGATCATG CGGCTCAGCA TGGGATTGAG TTAGGGCTTA AAATCCCCAC CATCAACACG 1860

AACTACTATT CCTTTATGGG GGCTGAACTC AAATACCGAA GGCTCTATAG CGTGTATTTG 1920

AATTACGTGT TCGCTTAC 1938

(2) INFORMATION FOR SEQ ID NO: 124:

(l) SEQUENCE CHARACTERISTICS: (A) LENGTH 279 base pairs

(B) TYPE nucleic acid

(C) STRANDEDNESS double

(D) TOPOLOGY circular

(ii) MOLECULE TYPE- DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE- NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

( x) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...279

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 124:

GATTTAAAAA TGCTGACGAT TGAAACCAGT AAAAAATTTG ATAAGGATCT TAAAATTCTT 60

GTTAAAAATG GGTTTGATTT AAAGCTTTTG TATAAAGTGG TTGGAAATTT AGCCACAGAG 120

CAACCCCTAG AACCCAAATA CAAAGACCAC CCACTCAAAG GCGCTTTAAA AGACTTTAGG 180

GAATGCCACC TAAAACCGGA TTTATTGCTT GTCTATCAAA TTAAAAAACA AGAAAACACT 240

CTTTTTTTAG TAAGGCTAGG CAGTCATAGC GAGCTGTTT 279

(2) INFORMATION FOR SEQ ID NO: 125:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 243 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...243

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 125:

CGCGCATGGA GAATGAAAAG CATGCGTTTT AGTTACATTG AGCCAAGAGC GAAATACTTA 60

ATCAGCAAGC TTTCTAAAAT TTGGGTTTTT TACATTTTTT TATCTTTTGT GCTAATAGGG 120

GGGTTAGTGT GGTTTATGCA CAACGCCATT AAACGCGCTC AAGACAACGC GTCTAGTCTG 180

ACGATCCAAG AAGAGCTTTA CCGCTGTTAC ATCACCCGCT TGTCTGTTAA GATGATTATA 240

CTC 243

(2) INFORMATION FOR SEQ ID NO: 126: (l) SEQUENCE CHARACTERISTICS

(A) LENGTH: 447 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS double

(D) TOPOLOGY- circular

(ii) MOLECULE TYPE DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM. Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...447

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 126:

GTTAAATTTC CTTATCTGTT AAACATACGG ATAATGTTAT ATCTAAGGAA AGAAAATGGG 60

GTTAGGACAC TAATAAGTTT AGGGATTTTG TTAAGCGTTT TGAATGGCGA TGATCTGAGA 120

TTGTATTCAA AACCTTTGGT CTATTCGGCT GGAAGTGGGA TTATTGGGAT TGATATTGAC 180

AAACGGACAT TCTATAAACG AGCGTTCGCT TTCACGATGA AATCGTTGTT TGGTGAAAAC 240

TTGCTTTTGT TTGTTAAATT GAAGCATTCT GCGTTGATGA GCAAACACAT GAAAGGGCCT 300

TTAGAAAACC GCCACCACCA TTCTTTCGCT AAAAATTATG AAAAAGCGGT TAATGGTTGT 360

CAAAAATATG TCCATATCAA ATTGCCTGAA GGGCCTCCTA GCAACTTCCA ATCAGGCTCA 420

TACATGGCGA CTATGGTGAT GCGTTTT 447

(2) INFORMATION FOR SEQ ID NO: 127:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 477 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...477

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:127:

GTCATCACCA ACCAACAAAA CGAAGTCAAA ACTTTCACGC CCATTGAAAC CAAAAAGATC 60

ACTTCCAAAG AACAAGCTTT TTTAACCCTT TCAGCGCTGA TGGATGCGGT AGAAAACGGC 120

ACAGGGAGTT TGGCTCGCAT TAAAGGTTTA GAAATTGCCG GTAAAACCGG AACTTCTAAC 180

AACAATATTG ACGCTTGGTT CATTGGCTTT ACCCCCACCT TACAAAGCGT GATCTGGTTT 240 GGGAGAGACG ATAACACGCC TATTGGCAAA GGAGCGACAG GAGGCGTTGT GAGCGCGCCT 300

GTGTATTCGT ATTTCATGCG CAATATCTTA GCGATTGAAC CTTCTTTAAA AAGAAAGTTT 360

GATGTCCCCA AAGGCTTGCG TAAAGAAATC GTGGATAAAA TCCCCTACTA CTCAAGCCCT 420

AATTCCATCA CCCCCACCCC CAAAAAAACA GACGATAGCG AAGAACGCTT GTTGTTC 477

(2) INFORMATION FOR SEQ ID NO: 128:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 240 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...240

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 128:

TTATTGTTAA ATCTTAAGAT TTATGTTACA CTCTGTAAAA TCCAAGGGGA TAGCGTGTTA 60

GAAAAATCTT TTTTAAAAAG CAAGCAATTG GTTTTATGCG GGTTGGGTGT TTTTATGTTG 120

CAGGCTTTGC ACTTCGCCCA AACACTTCAC AAAGAAATTC TTTTTTACAA GATGTGCCTT 180

ATTGGATGTT GCAAAATCGC AGCCAGTATC TCACGCAAGG GGTGGATAGC TCGCACATTG 240

(2) INFORMATION FOR SEQ ID NO: 129:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1032 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(i^'i) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1032

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 129: GTCAAGTGTG GCAAAAAGGG GATTTTAGTT TCAACGCGCA AGGCAATGTT TTTGTGCAAA 60 ATTCCACTTT CTCTAACGCT AATGGAGGCA CGCTCAGTTT TAACGCAGGA AATTCGCTCA 120

TTTTTGCCGG AAACAACCAC ATCGCTTTCA CTAACCATTC TGGAACGCTC AATTTGTTGT 180

CTAATCAAGT TTCTAACATT AACGTCACCA TGCTTAACGC AGCAACGGCC TAAGATTAAC 240

GCCACTAATA ACAATGTTTC CGTGTCTCAA GGCAATCTGT TTATCAACGC TAGCTGCGTG 300

CAACAAAGCG ATCCAACGAC AGCTAGCGCC ACAAACCCTT GCACCACCGC TCAAAATAAC 360

GCTTCTTCTA GTAATGCGTC AAACAACGCG CCAATCGCCT TAAATAATAA CGATGAAAGC 420

TTGGTGGTTA CGGCGAATGG TTTCAATTTT TCAGGCAATA TTTACGCTAA CGGGGTGGTT 480

GATTTTTCAA AAATTAAAGG CTCTGCAAAC GTTAAAAACC TGTATCTTTA CAATAACGCT 540

CAATTCCAAG CCAACAACCT CACGATTTCC AACCAAGCGG TATTAGAGAA AAACGCTAGC 600

TTTGTAACGA ATAACTTAAA CATTCAAGGA GCGTTTAACA ACAACGCCAC GCAAAAAATA 660

GAGGTGCTTC AAAATTTAGT GATCGCTTCA AACGCTTCTT TAAGCACCGG GATTTATGGG 720

TTAGAAGTAG GGGGGGCATT GAATAATTTG GGAGCGATCC ATTTTAATTT AGAAAATTCT 780

CAAACGCCTG TAAATCCGCT CATTCAAGTA GGGGGGATCA TTAATCTCAA CACCACCCAA 840

ACGCCTTTTA TGAATGTCAG CGTGGCTAAT GGCGGAACTT ACACTTTATT AAAAAGCAGC 900

CGTTATATTG ATTACAATAT CAACCCTAAC AGCTTGCAAT CGTATTTGAA GCTCTATACC 960

TTAATCAATA TCAACGGAAA CCACATAGAG GAAAAAAACG GCGTATTGAC TTATTTGGGC 1020

CAACGGGTTT TA 1032

(2) INFORMATION FOR SEQ ID NO: 130:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 798 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...798

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 130:

TTGTTGGCGC GCACCATACT TGATTTTAGA GGCAGCCTTA GTAATTTAAA CAACACTTAT 60

AACAGCATCA CCACGACCGC TTCAAACACG CCTAATTCCC CATTCCTTAA AAATTTGATA 120

AGCCAATCCA CTAACCCTAA TAACCCCGGG GGCTTACAGG CCGTTTATCA AGTCAACCAA 180

AGCGCTTATT CGCAATTATT AAGCGCCACG CAAGAATTAG GGCATAACCC TTTCAGACGC 240

GTTGGATTAA TCAGCTCTCA AACCAACAAT GGTGCCATGA ATGGGATCGG TGTGCAAGTG 300

GGCTACAAAC AATTTTTTGG TGAAAAGAGA AGGTGGGGGT TAAGGTATTA CGGCTTTTTT 360

GACTATAACC ATGCTTAT T CAAATCTAGC TTTTTCAATT CGGCTTCTGA TGTGTTCACT 420

TATGGGGTAG GGACAGATGT CCTCTATAAC TTTATCAATG ATAAAACCAC CAAAAACAGC 480

AAGATTTCTT TTGGGGTGTT TGGGGGGATT GCGTTAGCTG GCACTTCATG GCTGAATTCC 540

CAGTATGTGA ATTTAGCGAC CTTCAATAAT TTCTATAGCG CTAAAATGAA TGTGGCGAAT 600

TTCCAATTCT TGTTCAATTT AGGCTTGAGA ATGAACCTCG CTAAGAATAA GAAAAAAGAC 660

AGCGATCATG CGGCTCAGCA TGGCGTGGAA TTGGGCGTGA AAATCCCTAC CATTAACACC 720

AATTATTATT CTTTTCTAGG CACTAAGCTA GAATACAGAA GACTCTATAG CGTGTATCTC 780

AATTATGTGT TTGCGTAT 798

(2) INFORMATION FOR SEQ ID NO: 131: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH. 285 base pairs

(B) TYPE nucleic acid

(C) STRANDEDNESS- double

(D) TOPOLOGY- circular

(ii) MOLECULE TYPE DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi ) ORIGINAL SOURCE:

(A) ORGANISM- Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...285

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 131:

CGCAACGTGG AAGCGCGTTA TTATTATGGG GACACTTCAT ACTTTTATTT GCATGCGGGA 60

GTTTTACAAG AGTTCGCTCA CTTTGGATCG AATGATGTGG CGTCTTTAAA CACCTTTAAA 120

ATCAATGCCG CTCGCAGTCC TTTAAGCACC TATGCAAGAG CGATGATGGG TGGGGAATTG 180

CAATTGGCTA AAGAAGTGTT TTTGAATTTG GGCGTGGTTT ATTTGCACAA TTTGATTTCC 240

AACGCAAGCC ATTTCGCTTC CAATTTAGGA ATGAGGTATA GTTTC 285

(2) INFORMATION FOR SEQ ID NO: 132:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 465 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...465

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 132:

AGACTTCCTA AAAAAGAAGA TTACGCTAAG GCGATGGTGT TTTCTTTTAA AATGGAAGCC 60

ATCAAAGAAA GCCAAATCGT TTTATTGATC ACTTCAGCGT TTGAGGGCCA ATTTGAAAAA 120

ACGCATAAAG AAGAAAAAGA AGAAACGACA AAAAGCGCTA CTGAAGAGAC TAAAACCCAC 180

GACGCGTCTT TAGAAAATAT AGAAATCCGC AATATCAGCA TGCTTTTAGA CGTGAAATTG 240

AACGTTAAGG TGCGTATCGG TCAAAAAAAG ATGATTTTAA AAGATGTGGT CTCTATGGAT 300

ATAGGGAGCG TGGTGGAGTT GGATCAATTG GTGAATGACC CTTTAGAAAT CCTCGTAGAT 360 GACAAGGTGA TCGCTAAGGG CGAAGTGGTG ATCGTGGATG GGAATTTTGG CATTCAAATC 420 ACGGATATTG GCACTAAAAA GGAACGATTA GAGCAACTGA AAAAT 465

(2) INFORMATION FOR SEQ ID NO: 133:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 633 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...633

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 133:

AAACCTACCA ATGTTTGGGC TAACGCTATT GGGGGAGCGA GCTTGAATAG CGGCTCTAAC 60

GCTTCATTGT ATGGCACAAG CGCCGGCGTA GACGCTTTCC TTAACGGGAA TGTGGAAGCC 120

ATTGTGGGCG GTTTTGGAAG CTATGGTTAT AGCTCCTTTA GCAATCAAGC GAACTCTCTT 180

AACTCTGGGG CCAATAACGC TAATTTTGGC GTGTATAGCC GTTTTTTTGC CAACCACCCT 240

GAATTTGACT TTGAAGCTCA AGGGGCGCTA GGGAGCGATC AATCAAGCTT GAATTTCAAA 300

AGCACTCTAT TACAAGATTT GAATCAAAGC TATAATTACT TAGCCTATAG CGCCACAGCA 360

AGAGCGAGTT ATGGTTATGA CTTCGCGTTT TTTAGGAACG CTTTAGTGTT AAAACCAAGC 420

GTGGGCGTGA GCTATAACCA TTTAGGTTCA ACCAACTTTA AAAGCAATAG CCAATCACAA 480

GTGGCTTTAA AAAATGGCGC GAGCAGTCAG CATTTATTCA ACGCTAACGC AACGTGGAAG 540

CGCGTTATTA TTATGGGGAC ACTTCATACT TTTATTTGCA TGCGGGAGTT TTACAAGAGT 600

TCGCTCACTT TGGATCGAAT GATGTGGCGT CTT 633

(2) INFORMATION FOR SEQ ID NO: 134:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1029 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature (B) LOCATION 1...1029

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 134:

CATGCTAGGG AATTTTGCCA AGTTGTGATG TTTCACAAAG CCCTTATTAC CTTTATCGTT 60

CTATGGTTTT TTTTGAATGG CTTAGGGGCT TATGATTTCA AGCATTGTCA GGCTTTTTTT 120

AAAAAAGCGA GCCTTCAAAA AGGGGGCGTG GCTTTAAAGG AATTGCCTAA GGGCGTGTAT 180

TTGTATTATT CTAAAACCTA CCCCAAACAC GCTAAAGTCA TCAAATCCGA TCCTTTTATA 240

GGGCTGTATT TGTTGCAAAG CGCGCCAAGC GAGTATGTTT ATACATTAAG GGATTTAGAC 300

AAAGACGCCC TTATAAGACC CATGGCCAGT ATAGGGGCTA ATCAAGCCAC AGAAGCGCGA 360

TTATTGGTAG GGCAAAAAGG CTATGACCGC TACGCTCAAA TTTCACAAAA AACCCAAAAA 420

AATGGCGTTA TCAGCAATAT TTGTTATCAA ATGCTAGGGC TAGGGGTAGG GGGGAACGGC 480

TTTATAGAAA CGAAATTCAT CAAGCGCTTT TTAAACCAAC AAGAGCCTTA TTATGGGGAT 540

ATTGGGGTGC GTTTAGAAGA ACGTCATAAG CGTTTGGTGG TAGCGCAATT TGATCCCTTT 600

TTCCCTAAAA ACCCTTTTTT AAAAAACGAT GAAATCCTAG CGATCAATGA TTACAAGATC 660

CACTCGTTAG CGGAGTTTGA ATGGGTGGTG AGCAATCTTT CATACCAAAG CCTCGCCAAA 720

GTGAAAATCA AACGAAACCA TCAAATCAAA GAAGTAACGC TCAAAGTCAA TAAACGCTAT 780

GGGGGGTTTT TGCTCAAAGA CACTTTTTTA GAGCGCTATG GCATCGCTTT AGACGAGCGT 840

TTTATCATCA CTAAAATAGG CGCTCATTTG CCCAAAGGCT TGGATTTTTT AAAGCTTGGG 900

GATAGGATTT TATGGGTGAA TCATAGAAGC GTTTCGTTCA ACCCGAAAGC TTTAAGAGAA 960

GCGTTAAGCA CGCCTAAAAT TGAATTATTA GTCTGGCGTC AAGGCTTTGA ATTTTACATT 1020

AAAGTCCGT 1029

(2) INFORMATION FOR SEQ ID NO: 135:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 495 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_£eature

(B) LOCATION 1...495

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 135:

ATTAAAATTA ACATGGTAGA ATGCCAAAAT TTGCTGTCGT CATGCGGCAA AAATTTAGAC 60

AACAAGGAAT TGGGAATGAG AAGGAGTTTG GCTTTTTGCC TTTTAGCTTT GCTTGGATTA 120

CAGGTTTTAG GTGCTAGAGA CTTTTCGCAA CTCAAAAACG AAGAACTTTT AAAATTAGCA 180

GGAACTCTGC CTTCTAATGA AGCGATTGAT TATCGCATGG AAGTGTCTAA ACGCCTTATA 240

GCCTTAAGTG CTGAAGACGC TAAGAATTTC CGCGCGAATT TCAGCCGGAT CGCTAGGAAG 300

AATCTTTCTA AAATGAGCGA AGAGGATTTC AAAAAAATGC GTGAAGAAGT GCGTAAAGAA 360

TTAGAAGAAA AAACCAAAGG TCTAAGCGCT GAAGAAATCA AGGCAAAAGG ACTTAATGTG 420

AGCGTTTGCA GCGGCGATAC GAGAAAAGTT TGGTGTAGGG CTGTTAAGAA AAAAGACGAA 480

CATTGCTCTC CTAAG 495

(2) INFORMATION FOR SEQ ID NO: 136: (l) SEQUENCE CHARACTERISTICS-

(A) LENGTH- 471 base pairs

(B) TYPE nucleic acid

(C) STRANDEDNESS. double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE- NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...471

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 136:

TTTAAAAGGA AAAACATGAA AAAAGCGTTG AAAATACTTT CTGTTGGCGC GTTGCTATTT 60

GTGGCTTTAA ACGCCAAAGA TTTCAGCAAA ACAAGCGATG AAGATTTGGC TAAAATGGCT 120

GGCGTTGTCG CTCCGCAGGA TATTGTGGAT TACACAAAAG AGTTGAAAAA GCGCATGGAA 180

AAGATGCCTG AAGACAAGAG AAAGGCGTTC CATAAACAAT TGCATGAATA CGCGACTAAA 240

AACACAGACA AAATGACCGT GGCGGATTTT GAAGCCCGCC AAAAAGCCAT TAAAGAAGCG 300

CTTAAAAAAG GCAATATGGA AGACATGGAT GATGATTTTG GGTTGAGATC ATGCAAGCAT 360

GGGAAAAAGC ACAAACACGA TAAGCATGGC AAGAAGCATG GCAAAAAACA TGACAAAGAT 420

CATGACGATA AAGACCATGA CCACCATGAT GAAGATCACA GCGATAAGCA C 471

(2) INFORMATION FOR SEQ ID NO: 137:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2031 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: m sc_feature

(B) LOCATION 1...2031

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 137:

ATCCAAAGAT ATTGGAATGG AGCGTTAATG AAAAATCAAC ACAAAAATCC CCTAACAAAA 60 GCTTTAATGA AAACTTATCC ATATAACCAT TTTTTATTTT TCTGCTTTAT TCTAGGAGCG 120 TTTTTATTAG GTTTGCTCAG TCCAGCTTAT GCTTTAAGTA TTATCACCAC TAAAGAAATT 180 GACGCTAATT TGCTTAATGG AGCGATAGAA AGCAGGGTGG TGTTAGGCAA GAGGGTGTTT 240

AAAGTAGAAG CTCATGGGTT TTATTTTAGA AACAATGCGA CTAACAGCAT AGATATAGAA 300

ATCACCAGTC TTTTAAGAGA CAATCAATCG TTTCCTTTGA CTAGCAGTGC TAAAACCAGT 360

TTAAAAATAC CTCCTAACGC CAAGATTAAA AAATCCACTA TCCTTGTTTT GAAAGGCGAG 420

AACGCTGAAG AAGTGGCTAA GATTTTAGGC GTTAGCAAAG AAGAATACCA AAAGCTAGAA 480

AACATCGCTC AAACCAAAGC GGCTAATGAC CCTATGTATG CTAACACGCC TTTTAGTAAT 540

GGTTCTGATA GTTCCTTTTA CGATAACAAT CCTAATAGCC CTAGCAATAA CGCTATCAAT 600

GGCAAAGATG GCGCAAATGG GAGTAACGGC TATGGGGCAA ATGGCAATGA TGGGGTAAAT 660

GGGATCAGTG GGAGTAATGG TGCAAATGGG AGTCATTCAA ATAATAATGC AATAGGCAGT 720

GGTATTGATA CAGATGGCGT GTTAGGGGTG GATGGGGTGA ATGGCTCTAG TTCTTCAAGT 780

GGCGGCTCTG TAGGGGGTTA TGAGAATAAT TTCACTAATC ATGGCTCTAC TAACAATAAC 840

ACAGGAGGGT ATGACAATTT TAATAATGGC AGCTCAAGTG GTGGGAGTTT AGGGAATGGG 900

GGGCTTTTCC CTATTCCTTT TGGTAATGGA GACACAAACA ATTCCAATAA TTCCACTAAC 960

ACCACTAGCC CAACTAATGG CAGTAGTTCT AATAACGCCA CTAATCCTAG TTCGCAAGAA 1020

AACAATTACT CCAGCCAGTA TTGTAAAGTG CCAGAGTTAA GCCCCAACAA CACGATGAAA 1080

CTAGATGTTA TCGCTAAAGA TGGCTCTTGT ATTTCTATGA ACGCTTTAAG AGATGACACT 1140

AAATGCGCTT ATAGATACGA TTTTGAAGCC GGTAAAGCCA TCAAGCAAAC GCAATACTAC 1200

TATGTAGATA GGGAAAATAA AACGCAAAAT ATCGGTGGTT GTGTGGATTT ACAAGGCGCT 1260

CAATACGCCA TGCAACTTTA CAAAGATGAC AGCAAATGCG CCTTACAAAC CACGAGCGAT 1320

AAAGGTTATG GTATGGGGAA AACGCAAACC TTTCAAACTG AAATCGTGTT TCGTGGGATG 1380

GACAATTTAA TCCATGTCGC TGTGCCTTGC AGCGATTATG CAAGGGTGCA AGACAGGATT 1440

GTTAGGTATG AAAAAAATGA TAAAACCCAA ACCTTAACGC CTATAGTGGA TCAGTATTAT 1500

AATGATCCTA ACAACCCTAA CAAGCAAGAG ATTTTAAATC GTGGGATTGC CACCCAATTA 1560

AGCTCGCAAT ATCAAGAATT TGCATGCGGT CAATGGGAAT ACAATGACGC TAAATTAGAA 1620

GCCAAAAGAC CTACAATGCT AAAAAGCTAT AACAAGCTTA ATGGAGAATG GGTAGAAGTT 1680

ACGCCCTGTA ATTTTGAAGC AGGGATTAAA AGCGGTGCGG TTGTTAGCCC TTATGTGATG 1740

GGCGTGCCTA GTTCTAAAGT CTTAAGCGAT ATTACTACAA GCCATTATTT TAGGATAGAA 1800

AGGAAAAATT ATGGTGAGAG AGAACAATGC CAAAAACTTT ATGGAGTCAA TCGTTGCCAA 1860

CCGCAATATT CCATACTGAT CCTAGTATCA CCGATTGGAG CGCCACTTAC AAAACCACTA 1920

CCACCCAAAC CACTCAACCT TATTTACGCC CAGCCCAAGA TAATGAAAAA CACCCCACAA 1980

CCTATAATCT TATCACCACT CAAACCACCA TCAACAGGAC TCAAAGCGTT T 2031

(2) INFORMATION FOR SEQ ID NO: 138:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 339 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...339

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 138:

ATGGCTAAAA TGAACGCTCC AGATGGGGTT GCCGTTTGGG TGAATGAAGA CAGGTGTAAG 60

GGTTGTGATA TTTGCGTGTC GGTATGCCCG GCTGGAGTTC TTGGCATGGG GATTGAAAAA 120 GAAAGGGTGC TTGGAAAAGT GGCCAAAGTA GCCTATCCAG AGAGCTGTAT TGGTTGCGTG 180

CAATGCGAGT TGCACTGCCC GGATTTTGCG ATTTACGTGG CTGACAGGAA GGATTTCAAA 240

TTCGCTAAAG TTTCTAAAGA AGCCCAAGAA AGAAGCGAAA AGGTTAAGGC CAATAAATAC 300

ATGCTCTTAG AAGAGACTAT TTTAGAAGGG AGAGGCAAA 339

(2) INFORMATION FOR SEQ ID NO: 139:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 987 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...987

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 139:

ATGACGACTA AAAGAGTGAA TACTGCCACA AACAAGATAA TGACATTAAA CACTTTCTTG 60

GATACATGTT TTCTTTTCTT CATCAGTATT CTTTTTTACC TAAGTATACC AATTTATCCT 120

AACAAAGTGG TGGTTGTCCC GCAAGGTTCG CTCAAAAAAG TGTTTTTTTC TTTGAAAGAG 180

CAAGGCGTGG ATATTAACGC TTTAGATTTG CTTTTGTTGC GCCTAATGGG CATGCCTAAA 240

AAAGGCTATA TTGACATGGG CGATGGGGCT TTAAGGAAGG GGGATTTTTT AGTCCGTTTG 300

ATCAAAGCGA AAACGGCGCA AAAAAGCGTT ACTTTAATCC CTGGAGAAAC CCGCTATTTT 360

TTCACGCAAA TTTTGAGCGA GACTTACCAA CTAGAAACAA GCGATCTCAA TGAAGCTTAT 420

GAAAGCATCG CTCCACGATT AAACGGCGCT GTGATAGAAG ATGGGGTGAT ATGGCCAGAC 480

ACTTATCATT TACCTTTAGG GGAGGACGCT TTTAAAATCA TGCAAACTTT GATTGGTCAA 540

TCCATGAAAA AACACGAAGC CTTAAGCAAA CAATGGCTTG GATACTACCA TAAAGAAGAG 600

TGGTTTGAAA AAATCATTCT CGCTTCCATT GTGCAAAAAG AAGCCGCTAA TGTTGAAGAA 660

ATGCCCCTGA TTGCGAGCGT GATTTTTAAC CGCTTGAAAA AAGGCATGCC TTTACAAATG 720

GATGGGGCTT TGAATTATCA GGAATTTTCA CACGCTAAAG TAACCAAAGA GCGCATTAAA 780

ACCGATAACA CCCCCTACAA TACCTATAAA TTTAAGGGCT TGCCTAAAAA TCCTGTAGGG 840

AGCGTGAGCT TAGAAGCGGT TAGAGCCGTG GTTTTCCCTA AAAAAACGGA TTTCTTGTAT 900

TTTGTGAAAA TGCCGGATAA AAAACATGCT TTCAGCGCAA CTTATAAGGA GCATTTAAAA 960

AACATTAATA TTTCTAATAA TCATTTT 987

(2) INFORMATION FOR SEQ ID NO: 140:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 444 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO

(v ) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...444

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 140:

AAATTCATGA GATTGTTGTT CTTGTTACTG AGCGCTACTT TGATGTTACT GGCTGAAGAA 60

AAAATACCTT TAAGCGATGA CGCCCCCATT AAATTGGTTC ATTGGCAAAA TGCGCTAAAA 120

GAAGTCCAAC CCGATTCAAA CGCTCCGGCA ACGCCACCTA TAAAGGCCGT GCAAACCACG 180

CTCACTTTTG AAACGCCTTT TAATAAAACG CCTAAAATCA TGGAGGTTGA AGGGCAAAAA 240

GTCATCGTGT TAAAAAACGC TCAATTGGAT TCTAAAAAAA CGATGGATTT TAAAGAAGCC 300

TCTTTGAATG CCTTAGAAAT GTTTTCCTAC CAAAATGACA TCTACCTCTT GTCTAAAAAA 360

GCTAAAGCGG GATTAGAAAT CCAAGCTTCA AGCAGCAAGG ATAAAAAGCA ACTCGCTTTC 420

TTTTTTTACC CAAAGGTTTT CATT 444

(2) INFORMATION FOR SEQ ID NO: 141:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 783 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...783

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 141:

GAATTGATTT TAAAGAAAAA GAAAGAAAGG AATTTAATGA AAAAAGGTAG TTTAGCAATC 60

GTTTTAGGAT CGTTACTAGC AAGTGGGACG TTTTATACGG CTCTAGCTGA TGGAATGCCT 120

ATGAAGCAAC AGCACAATAA CATGGGTGAG TCTGTGGAGT TGCATTTCCA CTATCCTATT 180

AAAGGCAAAC AAGAGCCTAA AAATAACCAT TTAGTTGTCT TAATCGATCC TAAGATAGAG 240

GCTAATAAAG TTATCCCTGA AAATTATCAA AAAGAATTTG AGAAGTCTTT GTTCCTCCAA 300

CTGAGTAATT TTTTAGAGAG AAAGGGCTAT AGCGTTTCGC AATTTAAAGA TGTTAGCGAA 360

ATCCCTCAAG ACATCAAAGA AAAAGCGTTG CTCGTTTTAC GCATGGATGG GAATGTGGCT 420

ATCTTGGAAG ATATTGTAGA AGAGAGCGAT GCGCTCAGTG AAGAAAAAGT GATAGACATG 480

TCTTCAGGGT ATTTGAATCT GAATTTTGTT GAGCCAAAAA GTGAAGACAT TATCCATAGT 540

TTTGGTATTG ATGTTTCAAA GATTAAGGCT GTGATTGAAA GGGTGGAATT GCGGCGTACC 600

AATTCTGGAG GTTTTGTCCC CAAAACTTTT GTGCATAGGA TCAAGGAAAC CGACCATGAC 660

AGAGCCATTA AAAAGATCAT GAATCAAGCC TATCACAAAG TGATGGCGCA TATCACCAAA 720

GAATTAAGCA AAAAACACAT GGAACGTTAT GAAAAAGTTT CTAGTGAAAT GAAAAAGCGA 780 AAG 783

(2) INFORMATION FOR SEQ ID NO: 142:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH. 804 base pairs

(B) TYPE, nucleic acid

(C) STRANDEDNESS- double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...804

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 142:

GACCAAAAAT TCAAGGGGAT TATTTTAGCT ATGAAAATCA GTGTTAGTAA AAACGATTTA 60

GAAAACACTT TGCGCTACTT GCAAGCTTTT TTGGATAAAA AGGACGCTTC CTCTATCGCT 120

TCACACATCC ATTTAGAAGT CATTAAAGAA AAGCTCTTTT TAAAAGCCAG CGATTCAGAT 180

ATTGGACTAA AAAGCTATAT TTCTACGCAA TCTACCGATA AAGAGGGCGT AGGCACGATC 240

AACGGGAAGA AGTTTTTAGA TATTATCTCA TGTTTGAAAG ACTCTAATAT TGTTTTAGAG 300

ACTAAAGATG ACAGCTTGGT GATCAAACAA AATAAAAGCT CTTTCAAACT CCCCATGTTT 360

GACGCTGATG AGTTCCCTGA ATTCCCTGTT ATTGATCCAA AAGTGAGTTT AGAAATCAAT 420

GCCCCCTTTT TGGTGGATGC GTTTAAAAAG ATCGCTCCTG TGATTGAGCA AACTAGCCAT 480

AAAAGGGAAT TAGCCGGTGT TTTAATGCAA TTCAATCAAA AACACCAAAC CCTTTCAGTG 540

GTAGGCACGG ATACCAAGCG GCTCTCTTAC ACGCAGTTAG AAAAAATCTC TATCCATTCC 600

ACCGAAGAAG ACATCTCTTG CATTTTGCCT AAAAGGGCTT TATTGGAAAT CCTTAAACTT 660

TTTTATGAAA ATTTCAGTTT TAAAAGCGAC GGCATGTTAG CGGTGGTTGA AAACGAAACG 720

CACGCTTTTT TCACCAAGCT CATTGATGGG AATTACCCTG ATTATCAAAA AATCCTCCCT 780

AAAGAATACA CTTCTCTCTC ACTT 804

(2) INFORMATION FOR SEQ ID NO: 143:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1248 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori ( ix ) FEATURE .

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...1248

(xi) SEQUENCE DESCRIPTION SEQ ID NO.143:

AACCCATTGA TTCAAAAGAA CAAGAGCTTA TCAATCTTTT TAATCTCAAA TTCGGTCGTT 60

TTTCTTGGGA AAATTATCTT GCATAAAGTT TTTATCATGG AAGCTTTGGA GTGTTTGAAA 120

AGAATAGAAA AAGAAAGCAT CCAAACAATC TATATAGACC CCCCTTATAA CACCAAGAGT 180

TCTAACTTTG AATATGAAGA CGCTCATGCT GACTATGAAA AATGGATTGA AGAACATTTG 240

ATTTTAGCAA AAGCTGTGTT AAAACAAAGT GGTTGTATTT TTATTTCTAT GGACGATAAT 300

AAAATGGCTG AAGTTAAAAT CATTGCCAAT GAAATTTTTG GAACGCGCAA TTTTTTAGGC 360

ACTTTTATCA CCAAACAAGC CACAAGATCT AACGCTAAAC ACATCAATAT TACTCATGAA 420

TATGTTTTAA GCTACGCTAA AAATAAAGCG TTCGCTCCTG GTTTTAAAAT CTTACGAACG 480

CTTTTGCCCA TTTATGCTAA AGCATTAAAA GATTTAATGC GAACGATTAA GAATGTTTTT 540

AAACAAAAAG GACAAGCTCA AGCCCAACTT ATTTTAAAAG AACAAATCAA AGAGTTATCC 600

CAAAAAGAAC ATTTTAATTT TTTAAAAAAT TATAATTTAG TGGATGAAAA AGGTGAGATC 660

TATTTCGCTA AAGATTTATC CACGCCTTCA AACCCGCGCA GTGTAGCGAT ACAAGAAATC 720

AATCTTTTTT TAGAACCCTT AAAAAGCAGA GGGTGGAGCA GCGATGAAAA GCTTAAGGAG 780

TTATATTATC AAAATAGACT TATTTTTAAG AATAATCGCC CTTATGAAAA ATATTACCTA 840

AAAGAATCGC AAGATAATTG TTTGAGCGTG TTAGATTTTT ATAGCCGACA AGGCACAAAA 900

GATTTAGAAA AATTAGGCTT AAAGGGGCTT TTTAAAACGC CAAAACCTGT AGCATTGATT 960

AAATATTTAT TATTATGCTC CACCCCTAAA GATTCTATTA TTTTAGATTT TTTTGCAGGC 1020

AGCGGGACAA CAGCGCAAGC GGTTATAGAA GTTAATAAGG ATTATTATTT GAATTGGTCT 1080

TTTTATTTGT GCCAAAAAGA AGAAAAAATT AAAAATAACC CGCAAGCTGT TAGCATTTTA 1140

AAAAACAAGG GGTATAAAAA CACGATTTCA GACATCATGC TGTTGCGTTT AGAAAAGATC 1200

ATCAAAAGAA GTGAATACGA AATTTTAAAA ACAAAATCTA TTTTATTT 1248

(2) INFORMATION FOR SEQ ID NO: 144:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 228 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...228

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 144:

AATTTTAGCG GTGAATCCAA AAAGCGCCTA AAGCACCCAG CCCCATTCCC AAGGGAATTA 60

CCCAGGCGTT GCATCCAATT GTTTTCTTTT TTGGAAGACA CGATTTTTGA TCCCTTTAGC 120

GGCTCTGGCA CGACTATTTT AGAGGCCAAC GCTTTAGGGC GTTTTAGCGT GGGTTTAGAG 180

ATTGAAAAAG AATATTGCGA GTTGTTCAAA AAGCGTATTT TAGAGAGT 228

(2) INFORMATION FOR SEQ ID NO: 145- (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 651 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...651

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:145:

AGGAGATGTT GTAGGAGGGA AGACACGAAG AGATATGTGA TAGAAGTGGT TATATCTTTA 60

AGCACAATGA CAAGTTTATT GTCAGCAGAG ACCCCTAAGC AAGAAAAGGC TATTAAGACT 120

AGCCCTACCA AAAAAGGTGA AAGAAATGCT GCTTTTATAG GGATTGATTA CCAGTTGGGT 180

ATGCTCAGCA CTACCGCTCA AAATTGTTCC CATGGGAATT GCAATGGTAA TCAAAGTGGG 240

GCTTACGGCT CTAATACGCC TAACATGCCT ACAGCGTCAA ACCCAACAGG AGGCCTTACT 300

CATGGCGCTC TAGGGACTCG TGGGTATAAA GGCTTAAGCA ACCAACAATA CGCTATCAAT 360

GGTTTTGGGT TTGTTGTAGG GTATAAGCAT TTTTTTAAGA AAGCCCCACA ATTTGGAATG 420

CGTTATTACG GATTCTTTGA TTTTGCAAGC TCTTATTATA AGTACTACAC TTATAATGAT 480

TATGGCATGA GAGACGCTCG CAAGGGTTCT CAAAGTTTCA TGTTTGGCTA TGGGGCTGGC 540

ACAGATGTGT TGTTTAACCC AGCTATTTTC AATCGTGAGA AACTTGCATT TGGGGTTTTT 600

CTTGGGCGTT GCGATTGGTG GCACCTCTTG GGGTCCAACA AACTATTATT T 651

(2) INFORMATION FOR SEQ ID NO: 146:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 321 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...321

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 146: GGGGGCGTGT GCGGCGTATT ATCGTTACAA GCGCATTTGA GCTTTGAAAA TTGCTCTAAG 60

CCCCTAGACT GCTCACTATT CGCTACAACT TGCACCCCGC AAAACCCGAT CGGCAGTTGC 120

ATGGTCAGCT CTCAAGGGGG CGTGTGCGGC GTATTATCGT TACAAGCGCA TTTGAGCTTT 180

GAAAATTGCT CTAAGCCCCT AGACTGCTCA CTATTCGCCA CAACTTGCAC CCCGCAAAAC 240

CCGATCGGCA GTTACATGGT CAGCTCTCAA GGGGGCGTGC GCGGCGTATT ATCGTTACAA 300

GCGCGTTTGA GTTTTAAAAA T 321

(2) INFORMATION FOR SEQ ID NO: 147:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1152 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1152

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 147:

AACTATAGTA ATAAAGATAA CCCCATGAGA TTTTTTTGCT TCTTTTTATT TTTTCTAACC 60

TTTTCAAACG CGCAGATAAT GATGACTTTT GATTCCCAAA CTAACGCCAA ACTTTCGCGC 120

TCCAACGAAC AGCTTTCTGA CATGCTTTAC AAACTCAATG AAAGTTTAAG AATCTATCAA 180

AACGTGCTTT CTAACAACCA GGATCAACTT AAAGAAATCA AAAAGGCTAA CAGCACCCTA 240

ACTAGCCAAA GGCGTTTTTT TAACGCTAGC CAGATCCGCC TTATGGACAC TGATGCACTA 300

TTGAAACAAA GCGCTTTGGA ATTAGAAAAA TTACAAGCTT TAGAAAAACA CTTAAAAGAG 360

AGCATGGAGC ATGAACGCTT AATCAAAGAA TCCCAAGCGC TTTTTTTGCA AGAGCATTGC 420

CCTTATTTGA GCGGCGTTAA GAATTTAGAA GAGGCATCAA ACGCTTTAGA AGTCCAAGAA 480

AAAAATAACG CCCTTTTCTT ACTCAAAGAG CCTAAACTCT TTCATTTGCT CTCACGATTG 540

GATTTGATGA GCGCTTTAAA CGCCTTATGC GATCAGGTTT TAGAAAATGA AATACAGGAT 600

CAACAATCCC ATAACAAAAC CCTAGAATAC AACGCCCTTA TGAACCATGA TTTTCAAGCC 660

TATAAA^'GCCA TGCGTTTGAA AAAAATTAAA AACAAGCTTC AAAGCCAAAT CCAAGCTAAA 720

GAAGACGCCC TAAAAACCTT TTTACCCCTA GAAAAACGCC CAGAGACTCT AGGCTCGAGC 780

GATTGTTGCG ACAAAGAAAA TCTCAAATCA TGCGCTAACC AATTACAGCA ACGCTACCAA 840

AACGCCCTAA TAGAGCGAGA TAAGGAATTA AAAAACGCTA AAAACAACAA AGAAAAGCAT 900

GCTCTAATCT TAGCCAATTA CGAACACACT TTAAAAACCT TGAATATAGA ATTTTTAAGC 960

GAATTGAGTG AGCAAATGGC GTTTTTGAAT GAGACCATGG CGTTAAACGC CCAAGTTTTA 1020

GCCCTTTTAG CCCAACAACA GACTAAAAAG CCCTTCAATG TGAGCGATGG TTTGAGCGGT 1080

GGGAAAGCCC TTATTAAAAA TATCCGCTTA GATCCGCATG GATTCCCTAG CTTTAAAAAT 1140

TTTAAGCAAG AG 1152

(2) INFORMATION FOR SEQ ID NO: 148:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 894 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double (D) TOPOLOGY: circular

(11) MOLECULE TYPE DNA (genomic)

(m) HYPOTHETICAL. NO

(iv) ANTI-SENSE- NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM. Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...894

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 148:

TTAGTATTCA AAAAGCCCTT TTTTAAAAAT AGGTTACTAA ACGTTACTAA TAAGTTAAAA 60

TTCGTGAAAA TAACCATAAT GATTAAAGAT TTTAACCACT ATTGTAGAAA AATAACGAGA 120

GGGTTTGTAA AAATTCCCAC CAAAAAACAA GGAGCAAAAA AGATGAAAAA AGCGGGTTTT 180

CTTTTTTTGG CGGCGATGGC TATCATTGTT GTGAGTTTAA ACGCCAAAGA TCCGAATGTG 240

TTGCGTAAGA TTGTTTTTGA GAAATGTTTG CCTAATTATG AGAAAAATCA AAATCCTTCA 300

CCATGCATAG AAGTCAAACC CGACGCCGGC TATGTGGTTT TAAAAGATAT TAACGGTCCG 360

TTGCAATATT TGTTGATGCC AACGACTCAC ATTAGTGGCA TTGAAAACCC TTTGTTGCTT 420

GATCCTTCTA CGCCTAACTT TTTTTACTTG TCATGGCAAG CGCGCGATTT TATGAGTAAA 480

AAATACGGAA AACCCATTCC TGATTATGCG ATCTCTTTGA CGATCAATTC TAAAAAAGGG 540

CGATCGCAAA ACCATTTTCA CATCCATATT TCTTGCATTA GCCTTGATGT GCGCAAACAG 600

CTGGATAATA ATCTAAAAAA TATCAACAGC CGTTGGTCGC CATTATCAGG TGGCTTGAAC 660

GGGCATAAAT ATTTGGCGCG TCGGGTAACA GAGAGCGAAT TAGCGCAAAA AAGCCCGTTT 720

GTCATGCTTG CTAAAGAAGT GCCTAACGCG CACAAACGCA TGGGAGACTA TGGCTTGGCG 780

GTGGTGCAAC AGAGCGATAA CTCCTTTGTC TTGTTAGCGA CACAATTTAA CCCATTGACT 840

TTAAATCGCG CTTCAGCCGA AGAGATTCAA GATCATGAAT GCGCGATTTT GCGT 894

(2) INFORMATION FOR SEQ ID NO: 149:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 537 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...537

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 149: CTAAGGCGTC TAGCTTTGAA TACAATGAAT AGCGTGTTAG AATGTAAAGA ATTAGCGCTC 60 TATGGAGGGA GTTTTGATCC TTTGCACAAG GCTCATTTAG CCATTATTGA GCAAACTTTA 120

GAATTATTGC CATTCGTTCA GCTGATTGTC TTGCCCGCTT ATCAAAACCC TTTCAAAAAG 180

CCATGTTTTT TGGACGCAAA AACCCGTTTT AAGGAATTAG AAAGAGCTTT AAAGGGAATG 240

CCTAGGGTGC TGTTGAGCGA TTTTGAAATC AAGCAAGAAA GGGCTGTGCC TACGATAGAA 300

AGCGTTCTTC ATTTCCAAAA ACTCTACCGC CCTAAAACGC TTTATTTAGT CATAGGAGCG 360

GATTGTTTGA GGCATCTTTC TTCTTGGACT AACGCTAAAG AGCTTTTAAA AAGGGTGGAA 420

TTAGTGGTTT TTGAAAGGAT TGGCTATGAA AAAATTCAAT TTAAGGGGCG TTATCACCCT 480

TTAAAAGGCA TTGACGCGCC GATTTCTTCT AGCGCGATTA GGGCTAGTTT AGGGGTT 537

(2) INFORMATION FOR SEQ ID NO: 150:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 807 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...807

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 150:

TCGTCAATAT TTGATTATAA TTATAAGGGA TTACATTTCT CCAATAAGAG ATATATCATG 60

CTAGGAAGCG TTAAAAAAAC CCTTTTTGGG GTCTTGTGTT TGGGCGCGTT GTGTTTGAGA 120

GGGTTAATGG CAGAGCCAGA CGCTAAAGAA CTTGTTAGTT TAGGTATAGA GAGCGTGAAG 180

AAACAAGATT TCGCTCAAGC TAAAGCGCAT TTTGAAAAAG CGTGTGAGTT AAAAGAAGGT 240

TTTGGGTGTG TTTTTTTAGG GGCGTTTTAT GAAGAAGGGA AAGGAGTGGG AAAAGACTTG 300

AAAAAAGCCA TTCAATTTTA CACTAAAGGT TGTGAATTAA ATGATGGTTA TGGGTGTCGC 360

CTACTAGGAA ATTTATACTA TAACGGACAA GGCGTTTCTA AAGACGCCAA AAAAGCCTCA 420

CAATATTACT CTAAATCTTG TGAATTGAAC CATGCTGAAG GGTGTACGGT CTTAGGAAGC 480

CTACACCATT ATGGCGTAGG CACGCCTAAG GATTTAAGAA AGGCTCTTGA TTTGTATGAA 540

AAAGCTTGCG ATTTAAAAGA CAGCCCTGGG TGTATTAATG CAGGATACAT GTATGGTGTG 600

GCAAAGAATT TTAAGGAGGC TATCGTTCGT TATTCTAAAG CATGCGAATT AAAAGATGGT 660

AGGGGGTGCT ATAATTTAGG GGTTATGCAA TACAACGCCC AAGGCACAGC AAAGGACGAA 720

AAGCAAGCGG TAGAAAACTT TAAAAAAGGC TGCAAATCAA GCGTTAAAGA AGCATGCGAC 780

GCTCTCAAGG AATTAAAAAT AGAGCTT 807

(2) INFORMATION FOR SEQ ID NO: 151:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 258 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi ) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...258

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 151:

CATTTTAACA TCTTTACAGA AGATAATCGT GAAATCAGCG GGAGCACTGA CAAGCTCAGT 60

TATAACGCGC TGAATGGGGA ATACAAATTA TTGCAAAATG CGGTGGTTAG AGAAGTGGGA 120

AAATCTAATG TCATCACCGG CGATGAAATC ATTTTAAACA AAACCAAGGG TTATGCTGAT 180

GTGTTGGGGA GCGCGAAGCG CCCGCTAAAT TTGTGTTTGA TATGGAAGAC ATTAATGAAG 240

AAAATCGTAA GGCTAAAT 258

(2) INFORMATION FOR SEQ ID NO: 152:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 276 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...276

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 152:

CCCAAATCCC CTAAAAAGAT CGTAAAAAGA TACGAAAAAA GCGCTTGGAA AATGCCAAAA 60

GAAAACACCA CCCACGAAGA CGCTTTAGCG AAATGCTTTG CGCCTGCAAT TTTTAAAGCC 120

ATCATGCTGA ATAAATTGAT ATTGGCGGTT GTGGCTGCTC CCATTATAAA GATGCTTAAA 180

TTGAGTAAAG AGATTTGGTG GAAAAAAATG GGCAAAAAAC ATGCGATAGA TTTTAAAATG 240

AGGATAAAGA TATTGGCTTC TTTAGCCCCT AGCTTT 276

(2) INFORMATION FOR SEQ ID NO: 153:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 555 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM. Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY. mιsc_feature

(B) LOCATION 1...555

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 153:

AATAAGGATC ATTTGATGTT AAACAAGTTT AAAAAAATCG TTGGCGTGGG TGTGTTAGTG 60

GGCTGTTTAG GGGTTTTGCA AGCTAAAAAC AGCTTATTTG TCTTACCTTA TGAGCAAAGA 120

GACGCTCTCA ATTCTTTAAT TTCTGGGATT AGCAGCGCTA GAGAGAACGT GAAAATCGCT 180

ATTTATAGTT TCACGCACAG AGATATTGCA AGAGCGATTA AAAGCGTAGC GAGTAGGGGG 240

ATTAAGGTGC AAATCATTTA TGATTATGAA AGCAATCACA ATAACAAGCA ATCCACTATT 300

GGCTATTTAG ACAAATACCC TAACACGAAA GTGTGCTTAT TAAAGGGGCT TAAGGCTAAA 360

AACGGGAATT ATTACGGCAT CATGCACCAA AAAGTAGCGA TCATTGATGA TAAAATCGTG 420

TTTTTAGGCT CAGCGAATTG GAGCAAAAAC GCTTTTGAAA ACAATTATGA AGTGTTTTTA 480

AAACGGGATG ACACAGAGAC GATCTTCAAA GCCAAGAGTT ATTATCAAAA GATGCTAGAA 540

GGTTGCGTTG GGTTT 555

(2) INFORMATION FOR SEQ ID NO: 154:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 645 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...645

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:154:

GGAAGAACAA TGAAATATTT ATGGCTTTTT TTAATATACG CTATAGGGCT TTTTGCAACA 60

GATAAAACGC TAGATATTAT TAAAACCATT CAAAAACTTC CTAAGATTGA AGTGCGCTAC 120

TCCATAGATA ACGATGCCAA TTACGCTTTA AAATTGCATG AAGTCTTAGC GAACGATTTA 180

AAGACTAGCC AGCATTTTGA TGTTTCTCAA AACAAAGAGC AAGGTGCTAT CAATTACGCA 240

GAACTCAAGG ATAAAAAAGT CCATCTTGTA GCGCTTGTGA GCGTGGCGGT AGAAAACGGC 300

AATAAAATTT CACGATTAAA ACTTTATGAT GTGGATACAG GAACGCTCAA AAAGACTTTT 360

GACTACCCCA TTGTAAGTTT AGATCTATAC CCTTTTGCAG CGCACAACAT GGCCATTGTG 420

GTGAATGATT ATTTAAAAGC CCCTTCTATC GCTTGGATGA AGCGCCTGAT TGTTTTTTCT 480

AAATACATTG GACCAGGAAT CACAAACATC GCACTAGCGG ATTATACGAT GCGTTATCAA 540 AAAGAAATCA TCAAAAACAA CCGACTCAAT ATTTTCCCCA AATGGGCGAA CGCTGAGCAA 600 ACGGAGTTTT ATTACACGCA GATGGCGGAA AAACGCCCAT GGTTT 645

(2) INFORMATION FOR SEQ ID NO.155

( ) SEQUENCE CHARACTERISTICS

(A) LENGTH- 528 base pairs

(B) TYPE nucleic acid

(C) STRANDEDNESS. double

(D) TOPOLOGY, circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi ) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...528

(Xl) SEQUENCE DESCRIPTION: SEQ ID NO: 155:

GCAGCTATGA TGTTTAATAA TGATATAGAC AGCGCGACCG GATTTTACAA ACCGCTCATC 60

AAGATTAACA GCGCTCAAGA TCTCATTAAA AATACAGAGC ATGTTTTATT GAAAGCGAAA 120

ATCATTGGTT ATGGTAATGT TTCTACAGGT ACCAATGGCA TTAGTAATGT TAATCTAGAA 180

GAGCAATTCA AAGAGCGCCT AGCCCTTTAT AACAATAATA ACCGCATGGA TACTTGTGTG 240

GTGCGAAATA CTGATGACAT TAAAGCATGC GGTATGGCTA TCGGCAATCA AAGCATGGTG 300

AACAACCCTG ACAATTACAA GTATCTTATC GGTAAGGCAT GGAGAAATAT AGGCATCAGT 360

AAAACGGCTA ACGGCTCTAA AATTTCGGTG TATTATTTAG GCAATTCTAC GCCTACTGAG 420

AATGGTGGCA ATACCACCAA CTTACCCACA AACACCACTA ATAATGCGCA TTCTGCTAAC 480

TACGCTCTCG TGAAGAACGC TCCTTTCGCT CACAACACCA CTCCTAAT 528

(2) INFORMATION FOR SEQ ID NO: 156:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 564 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi ) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...564 (xi) SEQUENCE DESCRIPTION SEQ ID NO.156

ATTTTTAGAG CTTTTAGAAG AGGATTTTTT AGAAAAACAT TTGCATATCG CTTTACAGCA 60

CACCATGATT TCATGCTAGA GAGAATGAAT CGAAGAAACC GCACTAAAAG CGATAGGGAA 120

TTATTAGAGA TAATCGCTTC TAAGAATTTT GCTATCGGCA CGGATTTTAT TGTGGGGCAT 180

CCGGGCGAGA GTGAAAGCGT TTTTGAAAAG GCGTTTAAAA ATTTAGAAAG CTTGCCTTTA 240

ACGCATATCC ACCCTTTTAT TTACAGCAAG CGAAAAGACA CCCCCTCTAG TTTGATGCGT 300

GATAGCGTGA GTTTGGAAGA TTCTAAAAAG CGTTTGAATG CGATTAAAGA TTTGATTTTT 360

CATAAAAATA AGGCGTTCAG GCAATTGCAA CTCAAACTCA ACACGCCCCT AAAAGCCCTA 420

GTGGAAGCGC AAAAAGACGG CGAATTTAAA GCCTTAGATC AATTTTTCAA CCCCATTAAA 480

ATCAAAAGCG ATAAGCCTTT AAGGGCTAGT TTTTTAGAAA TCAAAGAGTA TGAAATTAAG 540

GAGAGGGAAA ATCATGCCGT TTTC 564

(2) INFORMATION FOR SEQ ID NO: 157:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 237 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi ) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...237

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 157:

AAAGCACTGC CACAAGGTCG AAACAGAATG CGGTCGGATG TTGAAGTTTT ATCGCCTTTG 60

CATAAAATAG ATGAAAAATA CCTTTTCCAT TTAAAGATTG CGGGGGAATT GGCGAGCATG 120

GGTAAGATTT TAAGTGTATA TTTAGCCCAC AAGCACAGCG CGTATTTCAT TTTAAACGCT 180

TTGAGTTACG GCTTTAGCCA CCAGGATAGG GCGATCATTT GCTTATTGGG CGCAATT 237

(2) INFORMATION FOR SEQ ID NO: 158:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 705 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi ) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori (ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...705

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 158:

AAGGGAACAA AAATGAAAAA AGTCTATTTT AAAACTTTTG GGTGTAGGAC GAATCTTTTT 60

GACACGCAAG TGATGGGCGA AAATTTAAAG GATTTTAGCG CGACTTTAGA AGAACAAGAA 120

GCCGATATTA TTATTATCAA TTCTTGCACC GTAACCAATG GGACCGATAG CGCGGTAAGG 180

AGTTACGCTA GAAAAATGGC ACGATTGGAT AAAGAAGTGC TATTTACTGG TTGCGGGGTG 240

AAAACCCAAG GCAAAGAGCT TTTTGAAAAA GGGCTTTTAA AGGGCGTTTT TGGGCATGAC 300

AATAAAGAAA AGATTAACGC GCTTTTACAA GAAAAAAAGC GTTTTTTCAT AGATGACAAT 360

TTAGAAAACA AACATTTAGA CACCACGATG GTGAGCGAGT TTGTGGGAAA AACCAGGGCG 420

TTTATCAAGA TCCAAGAGGG CTGTGATTTT GATTGCAATT ATTGCATTAT CCCAAGCGTG 480

AGAGGGAGGG CTAGGAGTTT TGAAAAGAGG AAAATTTTAG AGCAGGTGGG CCTTTTATGC 540

TCTCAAGGGG TTCAAGAAGT GGTTTTAACC GGCACTAACG TGGGGAGCTA TGGGAAAGAT 600

AGAGGAAGCA ATATCGCGCG ATTGATTAAA AAATTAAGCC AGATTACTGG ATTGAAACGC 660

ATTAGGATTG GGAGTTTAGA CCTAATCAAA TCAACGATGA ATTTT 705

(2) INFORMATION FOR SEQ ID NO: 159:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 303 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...303

(x^'i) SEQUENCE DESCRIPTION: SEQ ID NO: 159:

GTTACGGCTT TAGCCACCAG GATAGGGCGA TCATTTGCTT ATTGGGCGCA ATTTAGCCAT 60

AAAAAAATCC TTAAAGACTA CGTTATCGCC CACATGAGTG CGATGATGCC AAGCCTTTTG 120

ACCTTGCAGT GGCTGAGTTT TATCCTTTCT TTAGCCGAAA ATTTGTGCCT GACAGACAGC 180

CATCATTTAA AATACACGCT AGAAAAAAAC AAGCTTGTGA TCCATTCTAA TGATGCGCTT 240

TACTTGGCTA AAGAAATGCT CCCCAAACTC ATTAAGCCCA TTCCTTGGAC GATAGAGTTT 300

GCT 303

(2) INFORMATION FOR SEQ ID NO: 160:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1227 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1227

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 160:

AGCGATGCGT TTTTAATCAT ACAAGATTTT AAAGAGCAGC GCATCATCCA TAAAATCATT 60

CAAACCCATT TCAAACGCAT GCGTGTGGTT TTGAGCGTGA AAAGAGATAG CGAAAAAACT 120

TTAGAAAACA ATGAAGAAAA TAAAGATGAA AAGCTCATTT TGATTGATGA ATTTGAAGTT 180

TTAGCCAATA AATTCATTTC TCGTTTGCCT AATATCCCTA GCACCCCTAG AGAGTTTGGG 240

TTAGGCAAGG GCGAGATCAT GGAGATTGAT GTGCCTTTTG GGAGCATTTT TGCTTATAGG 300

CATATTGGCT CTATCAGGCA AAAAGAATAC AGGATTGTAG GGCTTTATCG CAACGATGTT 360

TTGTTGCTCT CCACTAAATC TTTAGTCATC CAACCACGAG ACATTCTTTT AGTGGCAGGC 420

AATCCGGAAA TTTTAAACGC GGTGTACCAT CAAGTCAAAA GCAATGTGGG GCAGTTCCCA 480

GCCCCCTTTG GTAAGAGCAT TTATTTATAC ATTGATATGC GATTGCAGAG CCGAAAAGCG 540

ATGATGCGCG ATGTGTATCA AGCCTTGTTT TTGCACAAGC GTTTAAAGAG CTACAAGCTC 600

TACATTCAGG TTTTACACCC CACTAGCCCT AAGTTTTATC ATAAATTTTT ATCGCTAGAA 660

ACCGAAAGCA TTGAAGTGAA TTTTGATTTT TATGGGAAGA GTTTTATCCA AAAACTCCAT 720

GAAGACCACC AAAAAAAAAT GGGTTTGATT GTGGTAGGCA GAGAGCTTTT TTTCTTGAAA 780

AAACACCGAA GAGCCTTGCA CAAAACAGCC ACACCGGTTT ATAAAACCAA CACCTCTGGC 840

CTGTCTAAAA CCACTCAAAG CATTGTGGTT TTGAATGAAA GTTTAAGCAT TAATGAAGAC 900

ATGTCTTCAG TGATTTTTGA TGTGTCTATG CAAATGGATT TGGGCTTGTT GCTTTATGAT 960

TTTGACCCTA ACAAGCACTA TAAAAACGAG ATTGTCAATC ATTACGAAAA TTTAGCCAAC 1020

ACCTTTAACC GCAAGATTGA GATTTTTCAA ACCGATATTA AAAACCCTAT CATGTATCTC 1080

AATTCTTTAA GAAATCCCAT TTTGCATTTC ATGCCTTTTG AAGAGTGCAT CACGCAAACG 1140

CGCTATTTGT GGTTTTTATC CACTAAAGTG GAAAAATTAG CGTTTTTGAA CGATGATCAC 1200

CCTCAAATTT TTATCCCTGT AGCGGAG 1227

(2) INFORMATION FOR SEQ ID NO: 161:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 192 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature (B) LOCATION 1...192

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 161:

CCAAATGAAG CGAGCGCGGC TGTTAATGTG GGCTATAAGA TCAGTAAGAG TTTGACAGCG 60

AGCGTGAAAT TAGAATATTT GGGCGTGATG ACGCATTCAG GCTTTACGGT AGGGAGTTAC 120

AGACCCACGC CCGGCTCTAA AGCACTTTAT TCAGACAGGA GCCATCTAAT GACAACCCTT 180

AGCGCCAAAG TC 192

(2) INFORMATION FOR SEQ ID NO: 162:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 255 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...255

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 162:

TCCATAGTAT ACGGTAAAAA TAAATTATTC TCAGATGAAT TTTATGAAAA AATCGAGGAT 60

ATTTTAACAA ATAACAACCC AAGATACAAA CAAGTGTGCA TTATTTTTGA TGCAGACATA 120

AAAAAAGAGA ACCAAGAAAG CGATGCAGGT TTTGATAACA AGCTTAAGCA TATTCGTGAA 180

AAATTCAAAG AAAAAGGGAC TGATTTTCCC AAAGAACAAA TCTTTTATTC CCTAACAATC 240

AAGATGATGG CGATT 255

(2) INFORMATION FOR SEQ ID NO: 163:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 438 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature (B) LOCATION 1...438

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 163:

GTGCAAGCGT TTGATTATAA AATTGAAGTT TTGGCAGAGT CCTTTTCTAA AGTTGGCTTT 60

AATAAAAAAA AGATTGACAT AGCTAGGGGG ATTTATCCTA CAGAGACTTT TGTAACCGCT 120

GTGGGTCAGG GCAATATTTA TGCGGATTTT TTATCCAAAA GCCTTAAAGA TCAAGGGCAT 180

GTTTTAGAGG GAAAAGTCGG CGGCACAATC GGTGGGATTG CTTATGACAG CACGAAATTC 240

AATCAAGGCG GATCGGTTAT TTATAATTAT ATCGGTTATT GGGATGGCTA TTTAGGGGGT 300

AAAAGGGCCT TGCTTGATGG CACGAGTATC CATGAGTGCG CGCTTGGCTC TGATGGCAAG 360

GTGATTGATT CTATAGCGTG CGGGAACGCT AGAGCCAATA AAATCCGCCG TAATTACTTG 420

ATGAATACCC CCTTCTCA . 438

(2) INFORMATION FOR SEQ ID NO: 164:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 741 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...741

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 164:

TTCCGCTATA AGGATATATT TGCGGCTAAA GGGGGGCGTT ATCAATCCAA TGCTCCTTAT 60

ATGAGCTCTT ATACGCAAGG CTTTGAAATC AGCGCTAAAA TCAAGGATAA AAATGAGGGG 120

AGCCATAAAT TATGGTGGTT TAGCTCATGG GGTAGGGCGT TCGCTTATGG GGAGTGGATT 180

TATGATTTTT ACTCTCCAAG AACCGTGATT AAAAACGGGC GCACTCTAAA TTATGGTATC 240

CATTTAGTGG ATTACACTTA CGAAAGGAAA GGGGTTAGCG TCAGCCCCTT TTTCCAGTTT 300

TCGCCCC-GGA CTTATTATAG CCCTGGGGTG GCTGTAGGCT ATGATAGTAA CCCTAATTTT 360

AATGGCGTGG GCTTTAGATC CGAAACGAAG GCTTATATTT TGCTCCCTGT CCATGCCCCC 420

GTTAAAAGGG ATACTTATCG TTACGCTGTG AAAGCTGGCA CCGCTGGGCA AAGCCTGCTC 480

ATTAGGCAAC GATTTGATTA CAATGAATTT AACTTTGGGG GAGCGTTTTA TAAAGTATGG 540

AAAAACGCAA ACGCTTACAT AGGCACGACA GGAAACCCTC TAGGCATTGA TTTTTGGACC 600

AATAGCGTTT ATGATATAGG GCAAGCCTTA AGCCATGTGG TAACCGCTGA TGCCGTCTCT 660

GGTTGGGTTT TTGGTGGAGG CGTGCATAAA AAATGGCTGT GGGGGACTTT GTGGCGTTGG 720

ACTAGCGGCG CTTTAGCCAA A 741

(2) INFORMATION FOR SEQ ID NO: 165:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 390 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular (11) MOLECULE TYPE. DNA (genomic)

(ill) HYPOTHETICAL. NO

(iv) ANTI-SENSE. NO

(vi) ORIGINAL SOURCE.

(A) ORGANISM. Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...390

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 165:

TTTTCCCAAA GAACAAATCT TTTATTCCCT AACAATCAAG ATGATGGCGA TTTAGAAACC 60

CTATTATTAG AAATTGCTAA ACACGATGAA TTTCTTAAAT GCTTTGAAGG ATACTTAGAA 120

TGTATTAAAA GTAAAGAACA TTATAAACCG ATTAAAAACA TAAGAAAAAA TATGCTGTAT 180

GCCTATTTAG AAGCGCTTGG ATTAGAGAAT TTGACCAAGA CCAATATAGA TGTTTTTGAT 240

AGTAAAGGTA AAATAAAGAG TAGATATGAA GAAAACTACA AAAAATTAAC AGAAGAAGTT 300

ATTGATTTCA GCTCGAATTC TCTCATTCCC CTTAAAAATT TTCTAGGGCA ATTCGCAGAA 360

AATAAACAAA AAACAAATCC TAAAATTTTC 390

(2) INFORMATION FOR SEQ ID NO: 166:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 213 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(in) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi ) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...213

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 166:

ATTTACTTTA GCGCCAAGCG ATTCAACACC AAAAACACGC ATGGCACGGG TTGTACTTTG 60

TCTAGCTTGA TTGTGGGCTT ACTCGCTCAA GGGCTGGATT TAAAAAACGC TATCACAAAG 120

GCTAAAGAGC TTTTAACTAT CATCATTCAA AACCCCTTAA ACATTGGGCA TGGGCATGGG 180

CCTTTGAATT TGTGGAGCAT CAAAAAGCAT GTT 213

(2) INFORMATION FOR SEQ ID NO: 167:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 699 base pairs

(B) TYPE: nucleic acid (C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(11) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...699

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 167:

CGCCCTTCAT TCCAAAAACG CTGCGCCCAT TTTAACGCTA CTTTACCCAT TCTTTTAAAA 60

GTGCTAGAAA AACAAGATAA AGACCTTTTT CTTTTGCAAG TGGGTAACAG GATTATCCCC 120

ACCAAAAGCG AACAGGAATT AAAAATCAAT CAGCCTTATT TTGCGACTAT GCAAAGAAAT 180

CAGCTGGGCG ACATTGTGCT TAAAAATTTA GTGCCTGCCC CAAAAATCTT AGACGCATTG 240

GACGATTTGC CCGTTATTGA AATGAAGAAA TTAAAAGAAA TATTGAGCGC CAAAGACAAC 300

ACCCCCCTAA AAGAATACAA AGAACTTTTG AGCGAAAAAT TAATCCATGC TAAAAGCTCG 360

CAAGAGTTTT TGAATACAGC CAACATGCTT TTAAGCTTGC AATCGCAGGT TTTAAGCTTT 420

GTGGTTGAAA ACGAACGCAA AAAAGCTTTT TTACAGATGA AAGCCAAAAA ACAAAGCGTT 480

GATTTTTACG CTCTGTACCC TAACTTGGGC GAAATTGGCG GCGTTATTTA TTTAAAAGAA 540

AAAGAGAAAC AGCTTTTTTT AAAAACCACC CTCCAAAGGA CCAAAGAGGT TTTAAAAGAG 600

GCTCAAAACA CCCTTTTAGG CTTTTCTTTT GTGGAAATTG TGTGCGAAAA AACCCCCATG 660

CTTTTTGCCT TTGAAGATCG CTTATTGGAC ACGCTAGGG 699

(2) INFORMATION FOR SEQ ID NO: 168:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 462 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...462

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 168:

CTATTAGAGA TGATTTTTCG ATCAAGGCGT TCAAAATGGG GGGCGTTATG CAACGCTCAA 60 ATCATTGAAT GCGTAGCGAA CGCTTTAGAA ACTTGTGATT TTGGGTTGTG CGTTTTAGAT 120 CCGGTGATGG TGGCAAAGAA TGGGGCTTTG CTTTTAGAAG AGGAGGCGAT TTTAAGCTTA 180 AAAAAACGCC TTTTACCTAA AACCAATTTA CTAACCCCTA ACCTCCCTGA AGTCTATGCG 240

CTCACAGGCG TTCAAGCGCG AGACGATAAA AGCGCTTCAA AAGCGATGGG TGTTTTAAGG 300

GATTTAGGCG TTAAAAACGC TGTGATTAAA GGGGGGCATA CAGAACATTT TCAAGGGGAA 360

TTTAGCAACG ATTGGGTGTT TTTAGAAGAC GCTGAATTTA CTTTAGCGCC AAGCGATTCA 420

ACACCAAAAA CACGCATGGC ACGGGTTGTA CTTTGTCTAG CT 462

(2) INFORMATION FOR SEQ ID NO: 169:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 969 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...969

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 169:

TGGCTTCAAT CAAGGTGTTT TAGGGATAGC GCCTTTTGCC TTAGTTCCGA AAAATTGTTC 60

GGTAAAAATT TGAATAAAGT GGTCATTTTG GCATTAAGAG ACATTATCCA TGAATATGGG 120

CATACTTTAG GCTATACCCA TAACGGGAAC ATGACTTATC AAAGGGTGCG TTTATGCCAA 180

GAAGGAAACG GGCCAGAGGC ACGCTGTGAG GGCGGGCATG AAGTGGAGAA AAACGGCAAA 240

GAAGAGCTAG AATTCAGTAA TGGGCATGAA GTGCGAGACC ATGATGGTTA CACCTATGAT 300

GTTTGCTCTC GTTTTGGCGG CAAAAATCAG CCCGCTTTCC CTAGCAATTA CCCCAATTCC 360

ATCTATACCA ATTGCGCTCA AGTCCCCGCT GGGCTTATAG GGGTTACTAC CGCTGTTTGG 420

CAACAGCTCA TCAATCAAAA CGCCCTGCCC ATTAATTTCG CTAACCTAAA TAGCCAAACC 480

AGCCATTTAA ACGCCGGGTT GAATGCGCAA AATTTTGCAA CCTCTATGGT CAGCGCGATC 540

GCGCAAAATT TTTCCACCAC TTCCACTACC ACTTACCGCT CTTCAAGTAA GAATTTTAGA 600

AGCCCTATTT TAGGGGTTAA TGTTAAAATA GGCTACCAAC ATTATTTCAA TGACTACATC 660

GGGTTAGCCT ATTACGGCAT TATCCAATAC AACTACGCTC AAGCTAACGA TGAAAAAATC 720

CAGCAATTAA GCTATGGTGG GGGAATGGAT GTGCTGTTTG ATTTCATCAC CACTTACACC 780

AATAAAAAGC AAGACCATCC AACTAAAAAG GTTTTTGCTT CCTCTTTTGG GGTGTTTGGG 840

GGGTTAAGGG GCTTATACAA TAGCTACTAT GTCTTCAATC AAGTCAAAGG AAGCGGTAAT 900

TTAGATATAG TAACCGGGTT TAATTACCGC TACAAGCATT CTAAATATTC CATAGCGTTA 960

GCGTTCCTT 969

(2) INFORMATION FOR SEQ ID NO: 170:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 426 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (111) HYPOTHETICAL. NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM. Helicobacter pylori

(ix) FEATURE.

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...426

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 170:

TATGATTTCC TAGGGGTTTC CTTGCATGCC CTTAGCCCCC TAGAAGAACA AGAATTTTTA 60

ATTTCGTACC GCTTGAAAAT CGTTGATTCT AGAGTGATGG GTGAAGAGTA TTCTGTTTCT 120

AAACCTATCG TTAGTCGCAT TAAAACAGCC CCCTATGTTT TAGACTATCA TTGCTCTATC 180

ATCACTCGCA ACTTGCCCGA TTTGAAAAAC CCCTTGCTCC AAATAAAGCT AGAACGCTTC 240

CTTTTAGAAA TAGCGTTAAA AAAAGAAAAA GAGCGAGTCA TTGACTGCCT TTTAAAAAGC 300

CAAGTCGCTA TCACGCATTA TGATCACAGC TATAAAAACG GCACCACTAC CACAAGCATT 360

CTTAACCTCA AAGCCTTAAG CGTTAAAGCG AGTTTAGATG GGAGATATGC TGTCTTTAGA 420

TATTTT 426

(2) INFORMATION FOR SEQ ID NO: 171:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1032 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...1032

(Xl ) SEQUENCE DESCRIPTION: SEQ ID NO: 171:

GAGTGGTTAA TGCTAAAAAA GATTTTTTAT GGTTTTATCG TTTTATTTTT GATTATCGTA 60

GGGTTGTTGG CCGTTCTTGT CGCTCAAGTT TGGGTAACTA CGGATAAGGA TATTGCTAAA 120

ATTAAAGATT ATCGCCCCAG TGTCGCTTCA CAGATTTTAG ACAGAAAAGG GCGTTTGATC 180

GCTAATATTT ATGATAAGGA ATTTCGTTTT TATGCGCGTT TTGAAGAAAT CCCCCCACGA 240

TTTGTTGAAA GCCTTCTAGC GGTAGAAGAC ACCCTCTTTT TTGAGCATGG GGGGATCAAT 300

TTAGACGCTG TCATGCGCGC TATGATTAAA AACGCTAAAA GTGGTCGTTA CACTGAAGGG 360

GGTAGCACTC TAACCCAACA ACTCGTTAAA AACATGGTGC TCACACGGGA AAAAACCCTA 420

ACCAGAAAAC TCAAAGAAGC TATCATCTCC ATACGCATTG AAAAAGTCTT AAGCAAAGAA 480

GAAATTTTAG AGCGTTATTT GAACCAAACT TTTTTTGGGC ATGGGTATTA TGGCGTGAAA 540

ACCGCAAGTT TAGGGTATTT TAAAAAACCC CTTGACAAAC TCACGCTTAA AGAAATCACC 600

ATGTTAGTCG CCTTACCTAG GGCTCCAAGT TTTTATGACC CTACCAAAAA TTTAGAATTT 660

TCACTCTCTA GGGCTAATGA TATTTTAAGG CGGTTGTATT CTTTAGGCTG GATTTCTTCT 720 AACGAGCTCA AATCCGCTCT CAATGAAGTG CCAATCGTCT ATAACCAAAC TTCCACGCAA 780

AATATCGCTC CCTATGTCGT GGATGAAGTG TTGAAGCAAT TGGATCAATT AGACGGGTTA 840

AAAACTCAAG GCTATACCAT AAAACTCACG ATAGATTTGG ATTACCAACG CTTAGCGTTG 900

GAGTCTTTGC GTTTTGGGCA TCAAAAAATC TTAGAAAAAA TCGCTAAAGA GAAGCCAAAA 960

ACTAACGCTT CTAATGATAA AGATGAAGAC AACTTAAACG CCCAGCATGA TAGTTACAGA 1020

AACGAGCACC GG 1032

(2) INFORMATION FOR SEQ ID NO: 172:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 351 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...351

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 172:

ACGCCCAGCA TGATAGTTAC AGAAACGAGC ACCGGTAAGA TTTTAGCCTT AGTGGGGGGG 60

ATTGATTATA AAAAAAGCGC TTTCAATCGC GCCACGCAAG CCAAACGGCA GTTTGGGAGC 120

GCGATCAAGC CTTTTGTGTA TCAAATCGCT TTTGATAATG GCTATTCCAC CACTTCCAAA 180

ATCCCTGATA CCGCGCGAAA TTTTGAAAAT GGCAATTATA GTAAAAACAG CGTGCAAAAC 240

CACGCATGGC ACCCTAGCAA TTATACTCGC AAATTTTTAG GGCTTGTAAC CTTGCAAGAA 300

GCCTTGAGCC ATTCGTTAAA TCTGGCTACG ATTAATTTAG CGATCGCTTG G 351

(2) INFORMATION FOR SEQ ID NO: 173:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 624 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...624 (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 173:

CCCAGAGACC ACACTTATAG CTTAGAAGAC AGCACGCCTC ATGGCTCTTT GTTAGGGAGG 60

AATGGCGTTA CTTTAAATAT CCGCCAGGTT TTTTGGTGGG ATAATTTCAA CTGGTCCATT 120

GGCTTTTATA ACACCTTTGG CAATTCAGAC GCTTTTTTAG GCTCTCACAC CATGCCAAGG 180

GGGAATAACA CTTCCTATAT CAGTAATGAA ATCTCAGTAA CGACTAGGCA TGCCGGAATG 240

ATCGGCTATG ATTTTTGGGA TAATACGGCT TATGATGGGC TGGCTGATGC GATCACTAAC 300

GCGAACACTT TCACTTTTTA CACTTCGGTT GGAGGGATCC ATAAGCGTTT TGCATGGCAT 360

GTTTTTGGGC GCGTCTCTCA TGCGAATAAA AATGCGTTAG GGCAAGTGGG GAGGGCTAAT 420

GAATATTCCT TGCAATTCAA TGCGAGCTAT GCGTCCACTG AATCGGTTCT CCTTAACTTT 480

AGGATCACTT ATTATGGGGC TAGGATCAAT AAAGGGTATC AAGCAGGGTA TTTTGGAGCG 540

CCCAAATTCA ATAACCCGGA TGGCGATTTT AGCGCTAATT ACCAAGACAG AAGTTACATG 600

ATGACCAACC TCACGCTGAA GTTT 624

(2) INFORMATION FOR SEQ ID NO: 174:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 396 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...396

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 174:

CCAAGAATAC ACGATATGGG CGATTTAGAT TCTCTAAACA TCAGCCCGGA TCCTAACACC 60

CCTACCCTAT TGATTTTAAG CGCTTTAGAT AATTCTTTAA AAGATTACGC CCCCACCTTT 120

AACGTCTTAA AAAAAACTTT TAAAGATCGT TTGAGGGTGC TTATTTTACT CAATCAACCC 180

TATTCAAGCG ATGCAATCAA AGGCTTTATT GCGCCTTCTC AAACTGATTT GATGATTTTA 240

AACCCTAAAG ATACCGCTCT TTTTGATCAT TTAAACCATG ACGCTTTAAA CCATTCTTTT 300

AACATGCTCT TATATGACAA ACACCAATTG ATTAAAATGT ATCAAGGGAT CGTGCCAGCA 360

GAAATGCTCC AATTTGATAT TTCCAATTTA AAGGAC 396

(2) INFORMATION FOR SEQ ID NO: 175:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 366 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE.

(A) ORGANISM- Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...366

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 175:

AGAAGAAGCC TTTATTATGT GTTTATAAAA TCGTATGCCA TTTTAGCGGA AGCGACAGCC 60

CGTTTTGCGG GCGATTATGC GACAGAGAAT TTAACAAGCC GTATCGCTTT GCCTTGCTCA 120

GATTATGTGG GTCGTGTGAT AGGCAAAGAC GGGAAAAACA TTGAAGCGTT TAAAAAGATT 180

AGTGGGGTGG ATATAGAATT TAGCGAAGAC AGTAGCGAAT TGTGCTTGTC CAGTTTCAAT 240

ATTTATCGGC GTGAAGTGGC GAGCGAGACG ATTAAAATTT TAATAGAAGA CGGCCGTATC 300

CAGCCTAACA GGATTGAAGA GGTTTATCCT AAAATTCACC CGCAACATGG AAAAAGAATT 360

GCTTTC 366

(2) INFORMATION FOR SEQ ID NO: 176:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 750 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii] MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...750

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 176:

AAGACGGCCG TATCCAGCCT AACAGGATTG AAGAGGTTTA TCCTAAAATT CACCCGCAAC 60

ATGGAAAAAG AATTGCTTTC TGAAGGAGAG AGCGTGGTGC TAGAATTAGA GCTTGGAACT 120

ATGGAAGATG AGCTTAAAAT TTTAATAGGC AAAATGCGTT ATCGCTTTAG TTTTGGGCAA 180

AACGCTTTAC AGCATTCTAA AGAGATCGCT CTTTTATCCG GCTTGATTGC AGAACAGCTT 240

GGGGGGGATA AAAAACTCGC CAGAAGAGCC GGTATTTTGC ATGATATTGG TAAAGCGCTC 300

ACTCAAGAGC TTGGGAGAGA CCATGTGAAT TTAGGGGTTG AGGTGTGCAA GCGCCATAAA 360

GAAGACCCGG TTGTGATCAA TGCGATTTAT GCCCACCATG GGCATGAAGA AATCATGAGC 420

GTGGAGTGCG CGAGCGTGTG CGCGGCTGAT GCGCTTTCTG CAGGGCGTCC GGGCGCTAGG 480

AGAAAGAGCG ATGAAGAATA CGCTAAACGC ATGCAAGCTT TAGAAGAGAT CGCGTTAGAA 540

TTTGATGGGG TGGAAAAGGC GTATGCGATG GAGAGCGGGC GAGAACTAAG AGTGATTGTC 600

AAATCCAACC AAGTCAGGGA CAATCAAGTG CCTATTATTG CTAGAAAGAT CGCTAAAAGG 660

ATAGAAGAGA GCACTCAGTA TGTGGGCGAA GTGGGCGTGC AAGTGGTGCG AGAAAATCGT 720

TTCAAAACGA CCGCTACGCT AAGCAATGAT 750 (2) INFORMATION FOR SEQ ID NO: 177:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2412 base pairs (3) TYPE- nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...2412

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 177:

AGTTTGTGGC TTAAGTCAAA ATTCTTTCTT TTAATGGGCG TGGGTTTGCT CTCCCATTCA 60

CTCAACGCTT TAAGCCTCAC GCTCACGCAA GGCAAAGAAG AAGGAGAAGA TTTTTCGGTT 120

TTAACCTTAC GAAACGATAA GGCGTTTTCT TGCTCTTATG CTAATGAAAA ACCGCCGAGC 180

GGGATTGAAG CGTCTTTATC TATTATACAC GCTAAACGCC CCATAGAATG CGTGATAGAT 240

TCTATTCCTA AAGAGGGCTT TACCCCTTTA GAAAACGCTT TTTTCAATAT CACCTATTCC 300

ATGCGCCAGC AACAATTCAT TTTACACATC AAACCCAAAG TGATGCGAAG GCTCACCCTT 360

TTTTCTTTTG ATAGGGATTA TAAAAAAGCG ATCCCCCTTT TTGTGGAAAA CGACGCTAAA 420

GCCAAGATGT GGCAAATCAT AGGCTATGAT CAAAAAATCC CTTTTTTGAG CGAAAAAGAC 480

AACGCTCAAA AAGGCTTGAA TTTCCCCATT ATCATTAAAG ACGCTCAAAC CCCTATCATT 540

CAAGAGCTGG ATGTGAATAA CAAACCCCTA CTCACCACAA AGGGCTATGA TTTAAACGCC 600

TATTTAGAAG CTAAAAAACA AATGGATTCG CAAGCCTATT TTGACGCCTT ACGCACGATC 660

AGCCGCGCGT TTAAAAATTA CCCTCAAACG ATTTTTAAAA AAGATCTGTA TTTATTAGAA 720

ATTATCGCAT TAGGTAAATT AGGCATTAAA AAATCCTTAC TCATAGATAT TGGCACCCAA 780

TGGATTAAAA ATTACCCGAC TGATCCTAAT ATCCCTGAAG CGCTATACTA TGTCGCCAAA 840

GCTTTAGATG AAAACAACAA TTACAAACAA GCCGTGCGCT ATTACAAACG AATCCTTTTA 900

GAATACAAAA ACTCCCGCTA CGCTCCCTTA GCCCAAATGC GTTTAGCCAT TGAAGCGGCT 960

GAAGGCTCTG ATTTGAGCAA CGCTAATATG CTTTTTAAAG AAGCTTTTTC TAACGCCAAA 1020

GACAAAGAGA GCGCGAGTGA AATCGCGCTT AATTGGGCTG AAGCAGAGAT AAACTATCAA 1080

AACTTTAATA ACGCTAAATA TCTCATTGAT AAGGTGGTTC AATCCAACCC TGATTATCTT 1140

TCTATGCACA GCGAATTAGC CCTAGAATTG CTCAAGTTAT TGAAAAAAAA CCAAATGAAT 1200

GAAAGTGCGA TTGAGATCGC TCACTTGCTC CTCAATCAAG ATGATGACTT GAAAGCTAAA 1260

GAGCAAGCGC TCTATGATTT AGGGGCGTTG TATGCAAGGA TCAAGGATTT TAAAAACGCC 1320

CACCTTTACA ATCTGCAATA TTTGCAAGAC CATGCGGAAT TGGAGCGGGC TTCTGTCGTT 1380

AGAGCACGCG ATGAAAAAGC CCTTTTTTCA ATGGAAGGGA ACACGCAAGA AAAAATCGCC 1440

CACTACGATA AAATCATTCA AAATTTCCCT AATTCTAATG AAGCCCAAAA GGCTTTAGAG 1500

TTGAAAGCCC AACTCTTGTT TGACAATAAG CACTATGCTG AAGTTTTAGG CATGCAAAAA 1560

AATTTGCCCA AAGATTCTCC CTTGATCCAA AAAACGCTCA ATATCCTTGC TAAAACCCCA 1620

TTAGAGGATC ATCGTTGCAA AGAAGCTTTA AAATACTTAT CCCAGATCAC CGCCTTTGCA 1680

TTCAACCCCC AAGAAGAAAT CCAAGCCTTT GATTGCTTGT ATTTCGCATC GCTCAAGGAA 1740

AAAGCGCAAA TTATTGCCCT AAACGCTTTA AAAGCGGCTA AAACCCCTAG CGAGAAATTA 1800

ACATGGCTTT ATCGTTTGGG GCGCAATTAC TACCGCTTAG GGGATTTTAA AAATTCCACT 1860

CTGGCTTCTA AAGACGCCTT AATCCTCGCT CAAAGCTTAA ATAAAAAAGA GTTTTATGAC 1920

ATTGCTTTTG TGTTATTTTC AGATTACATG CAAAACAATG AAAAAGGATT GGCCCTCAAT 1980

TTGTATGCGT TTTTAGAAAA GCATTTCAAA GACGATAAAC GCATGGCGTT GGTTTATTTT 2040 AAATTATTAG AGAATGAAAA AGACCCTAAA AGCGTTAAAA TTTATGCCAC AAGCTTACTC 2100

AAACTCCAAG ACGCTTATAA GGATTATTCT TACACGCCCT TTGGCGAATT TGCCCTTATT 2160

GACGCTTACA GAACCACCAA AGATTATTCA AAAGCGTTAG AAACGCTAGA CAAACTCTTA 2220

AACCGCAGGC TTTCTTTAGA AGATCACCAA AAAGCCTTAT ACTTGCAATC CAGCTTATTG 2280

GATTTAACCA ATCAAAAAGC AAAATCTAAA GCCAGTTTAG AAAAATGCGT TCAATTAAAG 2340

CAAAAAGATC AAACAAACGC ATGGCAAAAT TTATGCGAAC AGGGTTTAAA TTTATTCAAA 2400

AACAAGGAGT CA 2412

(2) INFORMATION FOR SEQ ID NO: 178:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1146 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1146

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:178:

AAACACCCAA ATCGTTTTTT CTTCAAAAGA ATTGAAAGAA CCGCACTCAA ACCCAATACC 60

TTCTTAAACG CGCCCATGCA AAAACCACAA AATAAACCCA GCTCATCGCA ACAATCTCCT 120

CAAAACTTTT CTTACCCAGA GTCCAAACTA GGCTCTAAAA ACTCTAAAAA CAGCCTTTTA 180

CAGCCTTTAG TAACTCCTAG CAAAGTAAGC CCCACTAACG AAGTTAAAAC GCCAACAAAC 240

GACGCTAATC CCCCTTTAAA GCATTCTTCA CAAGATCAAG AAAACAACCT CTTTGTAGCG 300

CCACCCACTG AAAAAACGCT CCCTAACAAC ACCTCTAGTG CTGATGCGAG TGAAAACAAT 360

GAAAGCAACG AAAATAGGGA TAATGTGGAA AAACAAGCGA TTAGAGATCC TAATATCAAA 420

GAATTCGCAT GCGGGAAGTG GGTTTATGAT GATGAAAATT TACAAGCCTA TCGCCCAAGC 480

ATTTTAAAAC GCGTTGATAA AGACAAAGAG ATTACAACAG ACATTACCCC TTGCGATTAC 540

AGCACCGCTG AAAATAAAAG CGGTAAAATC ATTACCCCCT ATACTAAAAT CTCTGTTCAT 600

AAAACAGAGC CTTTAGAAGA CCCTCAAACT TTTGAAGCTA AAAATAATTT CGCCATTCTC 660

CAAGCCAGAA GCTCTACAGA AAAGTGTAAA AGGGCTAGAG CGAGAAAAGA CGGCACGACC 720

AGGCAATGCT ATCTGATAGA AGAGCCTTTA AAACAAGCGT GGGAGAGCGA GTATGAAATC 780

ACCACGCAAT TAGTGAAAGC CATATATGAA CGCCCCAAAC AAGACGATCA AGTAGAGCCG 840

ACTTTTTATG AAACCAGCGA ATTGGCTTAT TCTTCCACAC GAAAAAGCGA AATAACGCGT 900

AATGAATTGA ATTTGAATGA AAAATTCATG GAATTTGTGG AAGTGTATGA GGGTCATTAT 960

TTAAACGATA TAATCAAAGA GAGCAGCGAA TACAAAGAAT GGGTTAAAAA CCATGTGCGC 1020

TTTAAAGAAA GGGTGTGCAT GGCCTTAAAA ATAAAAAAGC AACCACGAGC CAAAAGCACG 1080

CCTTTGAGTA TTGAAAACTC TCGTGTTGTG TGTGTCAAAA AGGGGAATTA TTTATTCAAT 1140

GAAGTT 1146

(2) INFORMATION FOR SEQ ID NO: 179:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 315 base pairs

(B) TYPE: nucleic acid (C) STRANDEDNESS- double

(D) TOPOLOGY circular

(11) MOLECULE TYPE. DNA (genomic)

(m) HYPOTHETICAL NO

(iv) ANTI-SENSE. NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM- Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...315

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 179:

ACCAAAAAGT TAAACAATAC TCTATTCAAT AAAGGATTAA TTATTTTTAA AATGTTTAAA 60

AAAATCATTT TTTTGTGCGT TTTTTTGATA GGGGGATTTG TCATTCCACC CCTTGAAGCC 120

ATGCCTATTT TGCGCAATAA AACCCCCAAA AAAAATTACC AAGAAGCCCA TGAAAAGCTC 180

TATAGAAGCA TCATTAACCG CCAAAAGCTC ACGCGTAAAA AAAGCGGGTG GTATTTTTTA 240

GGGGGGGTTG GCGCTGTAGA AGCCATTAAG GACTATCAAG GCAAGGAAAT GAAAGATTGG 300

ATGCCACGCT CAATT 315

(2) INFORMATION FOR SEQ ID NO: 180:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 207 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...207

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 180:

AGTAAAACTT CCTATTGCAA TTCTTACAAG CGTAAGCTCC TCCCCTACCA CTTTCTACTT 60

TTTCCATTAT GGGCGTGTTT TCACAATGTA AGCAGACCAT TTTCATTGAG CCATTTATTT 120

CTCGTAAAAC GCCCTTACAG TCGCCTTTAT TTACATAATC AGAGCAACCA TAAAATGAGA 180

CACCATTCAA TCCTCTTTGT ATCATTT 207

(2) INFORMATION FOR SEQ ID NO: 181:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1374 base pairs (B) TYPE, nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY, circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL. NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM- Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...1374

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:181:

CAAGATAAGG GGTTATTATT GAGTGTAGCA CTACCTAACT CAAACAACGC CTCTCAAAAC 60

AACATTTTAA GCCTTTCTGT CCTTCACAAC CAGATTAAAA TGTCTTATGG TAATAAAGTG 120

ATGGACTTTA CCCCTCCCAC CTTACAGGAT TACATTGTGG GCATTCAAGG ACAAAGCGCA 180

CTCAATCAAA TTGAAGCTGT TGGGGGGAAT AACGCTATCA AGTGGCTTTC AACATTGATG 240

ATGGAGACTA AAGAAAACCC GCTTTTTGCG CCGATTTATT TAGAAAACCA CTCTTTAAAT 300

GAAATCTTAG GCGTAACAAA AGATCTTCAA AACACCGCAA GCTTGATTTC TAACCCTAAT 360

TTTAGAAATA ACGCTACCAG CCTTTTAGAA ATGGCGAGTT ACACCCAACA AACCAGCCGT 420

TTGACAAAAC TCTCTGATTT TAGGGCTAGA GAGGGAGAGT CCAATTTTTC AGAGCGCTTG 480

TTAGAGCTTA AAAACAAGCG TTTTAGCGAT CCTAACCCTA GTGAGGTTTT TGTCAAATAC 540

TCTCAACTCA GCAAACACCC CAATAACCTT TGGATTCAAG GGGTGGGAGG AGCGAGCTTT 600

ATTTCTGGGG GCAATGGCAC GCTTTATGGC TTGAATGTGG GCTATGACCG ATTGGTTAAA 660

AGCGTGATCC TTGGGGGTTA TGTGGCTTAT GGCTATAGCG GTTTTAACGG GAACATCATG 720

CATTCTTTGG CTAATAATGT GGATGTGGGG ATGTATGCGA GGGCTTTTTT GAAAAGAAAC 780

GAATTCACTT TGAGCGCGAA TGAAACTTAT GGAGGCAATG CGAGTCATAT CAATTCTTCT 840

AATTCCTTGC TCTCTGTGTT GAACCAACGC TACAACTACA ACACCTGGAC AACGAGCGTG 900

AATGGGAATT ACGGCTATGA TTTCATGTTC AAACAAAAAA GCGTGGTGCT AAAACCTCAA 960

GTGGGCTTGA GCTATCATTT CATAGGCTTG AGCGGGATGA AAGGTAAAAT GCAAAATCCA 1020

GCTTACCAAC AATTCGTCAT GCATTCAAAC CCTTCTAACG AATCGGTTTT AACGCTCAAC 1080

ATGGGGTTAG AGAGCCGTAA ATATTTTGGT AAAAATTCCT ATTATTTTGT AACGGCGAGG 1140

TTGGGTAGGG ATCTTTTGAT CAAAGCTAAA GGCGACAATG TGGTGCGTTT TGTGGGTGAA 1200

AACACTTTAT TGTACCGCAA GGGGGAAATT TTTAACACTT TTGCGAGCGT GATCACAGGA 1260

GGCGAAATGC ATTTGTGGCG TTTGATGTAT GTGAATGCGG GGGTGGGGCT TAAAATGGGC 1320

TTGCAATACC AAGATCTTAA TATCACTGGG AATGTGGGCA TGCGAGTGGC GTTT 1374

(2) INFORMATION FOR SEQ ID NO: 182:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 558 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic) (ill) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...558

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 182:

CCCTTTGAAG CCTTGAATTT TTACTCCAAA AAAGCGTTGA ATGAGATTTT TGCAAACGCT 60

AGGAAAATTT GCGGGAACAA GCCTTTGGGG GCGAATATTT TATACGCTAT CAATGACTAT 120

GGCCGTGTTT TAAGGGACTC TTGTGAGGCG GGGGCGAATA TTATCATTAC AGGGGCTGGT 180

TTGCCCACTA ACATGCCTGA ATTCGCTAAG GATTTTAGCG ATGTGGCGCT CATCCCTATC 240

ATTTCCTCAG CGAAGGCTTT AAAAATCCTT TGTAAAAGAT GGAGCGATCG CTATAAAAGA 300

ATCCCGGACG CATTCATTGT GGAAGGGCCT TTGAGTGGGG GGCATCAGGG CTTTAAATAC 360

GAAGATTGTT TCAAAGAAGA ATTCCAATTA GAAAACTTAG TGCCTAAAGT CGTGGAAGCT 420

TCTAAAGAAT GGGGGAATAT CCCTATCATC GCCGCGGGGG GAATTTGGGA TAGGAAAGAT 480

ATAGACACCA TGTTAAGCCT TGGAGCGAGT GGGGTGCAAA TGGCGATCTC GTTTTTTAGG 540

CACGAAAGAA TGCGACGC 558

(2) INFORMATION FOR SEQ ID NO: 183:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 264 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...264

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 183:

GCTATCCGGC TTAGGCTATC AATACGGGGG TTGATCAAAC GCATTGAAGA AGGTAACGCG 60

CCTAAAATCG CATGCGTGAG CAATTGTGTA ACGCCTTGTA ACAGGGGTGA AGAAACTAAA 120

AAGGTGGGCT ATTGTATCGC TGATGGTTTG GGGCGCAGTT ATTTAGGAAA CAGAGAAGAG 180

GGGCTTTATT TTACCGGGGC TAATGGCTAT AGAGTGGATA AGATTATCAG CGTGCATGAA 240

TTGATTAAAG AGCTTACAGA GGGT 264

(2) INFORMATION FOR SEQ ID NO: 184:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 852 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular (11) MOLECULE TYPE. DNA (genomic)

(ill) HYPOTHETICAL. NO

(iv) ANTI-SENSE- NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_£eature

(B) LOCATION 1...852

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 184:

AATTTCAATC AAAGGGCTTT TTTGAAACGA GCGTTATGGT TAATTTTAGG GCTTTTTTAC 60

GCGCTTAATG CAGAGAGCTT TAAAGATGTT TTGACTAAAG GGGATTACAC TTTTTTTAAT 120

AAAAAGGTGG TTTCGCCTAT CAAACGCTAT GCGGATAGAT CGGCGTTTTA TCTGGGGCTT 180

GGGTATCAAT TAGGGAGCAT TCAGCACAAC TCTAGCAACT TGAATTTATC CCAACGATTT 240

AATAAGAGTC AGATTATTTT CAGCGATAGT CTAAGCCCTG TTTTTAAAAA TTCGTATGTG 300

TCTAATGGTC TTGGCGTTCA AGTGGGCTAT AAGTGGGTGG GTAAGCATGA AGAGACGAAA 360

TGGTTTGGCT TCAGGTGGGG GCTGTTTTAT GATTTGAGCG CTTCTCTTTA TGGCTCTCAA 420

GAATCGCAGT CTATCATCAT TTCCACTTAC GGCACTTATA TGGATTTATT GCTTAACGCT 480

TATAATGGGG ATAAGTTTTT TGCCGGGTTC AATCTGGGGA TCGCTTTTGC TGGAGTGTAT 540

GACAGATTGA GCGATGCGTT ATTGTATCAA ACTCTTCTTC AAAACACTTT TGGCGGGAAA 600

GTGAATTTAA ACGGCTTCCA GTTTTTGGTG GATTTAGGGG TTCGTTTAGG GAATGAACAC 660

AACCAATTTG GCTTTGGGAT TAAAATCCCT ACTTATTATT TTAACCATTA TTATTCCATG 720

AATAACATTA GCAATAATAG TGAAAATGTC TTAAAAGTTT TACGATTTTT AGAATACGGG 780

ATCAACAGCT TGTTGTATCA AGTTGATTTC AGGCGCAATT ACTCGGTTTA TTTCAACTAC 840

ACTTATAGTT TT 852

(2) INFORMATION FOR SEQ ID NO : 185:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 198 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi ) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...198

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 185:

AAAATGCACA CGAGTTTTTT CCAAATCCCT TTGAATTTTG GGGTTCGTGT GAATGTGGAT 60 AGGCACAATG GCTTTGAAAT GGGCTTAAAG ATCCCTTTAG CGGTCAATTC CTTTTATGAA 120 ACGCATGGCA AGGGGTTAAA CGCTTCCCTC TTTTTCAAAC GCCTTGTCAT GTTTAACGTG 180 AGTTATGTTT ATAGTTTT 198

(2) INFORMATION FOR SEQ ID NO- 186.

(l) SEQUENCE CHARACTERISTICS.

(A) LENGTH: 414 base pairs

(B) TYPE nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...414

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:186:

ATCAAACGCA TCATTAAATC AAACGCATCA TTAAATCAAT TAAATACCAC TAGATACAAT 60

ACCCCAAGTC ATCTTTTTTT CAAAAAAGGG GTAGGAATGG CAACCATTCA ACCATTCAAC 120

CATTCAACCA TTCAACCATT CAACCATTCA ACCATTCAAC CATTCAATCA TTCAATCATT 180

CAATCATTCA ATCATTCAAC CATTCAAGCA ACGCTACCTT ATTTTTATAA CTATTTATCT 240

TTTTACAAAA ACCTATTTAA AAATCCCCTA TTTTTTATTA TTCCCCCTTT TATTAACCCT 300

TTTATTAACC CTTTTATTAA CCCTTTTATT AACCCTTTTA TTAACCCTTT TATTAACCCT 360

TTTATTAACC CTTTTATTAA CCCTTTTATT AACCCTTTTA TTAACCCTTT CATA 414

(2) INFORMATION FOR SEQ ID NO: 187:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 579 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...579

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 187: CGCTACCACC ACTTCTCCGG CCTATCAAGC TGTGGCTTTA GCGCTCAATG CGGCTGTGGG 60 CATGTGGCAA GTCATAGCCT TTGGCATCAG CTGTGGCCCT GGCCCAATCT TGGCCCAGAA 120

CATTTAGAAA ATGGGGGCGT TCGATCGTTT GACAACACGC CAAACTACAG CTACAACACC 180

GGTAGCGGAA CGACCACCAC CACTTGTAAT GGAGCCAGTA ATGTAGGGCC CAATGGTATC 240

CTATCTAGCA GCGAATACCA GGTTCTCAAT ACCGCTTATC AAACTATCCA AACCGCTTTA 300

AACCAAAACC AAGGAGGCGG GATGCCTGCC TTGAATAGCT CCAAAAATAT GGTAGTCAAT 360

ATCAATCAAA CTTTCACAAA AAACCCTACC ACAGAATACA CTTACCCCGA TGGGAATGGC 420

AATTATTATT CAGGCGGTTC ATCAATCCCA ATCCAGCTAA AGATTAGTAG CGTCAATGAC 480

GCTGAAAACC TTTTGCAACA AGCCGCTACT ATCATCAATG TCCTTACCAC CCAAAACCCG 540

CATGTGAATG GTGGTGGTGG GGTCATGGGG GTTTGGCGG 579

(2) INFORMATION FOR SEQ ID NO: 188:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1254 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1254

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 188:

ATGGTGGTGG TGGGGTCATG GGGGTTTGGC GGTAAGACCG GGAATGTGAT GGATATTTTT 60

GGCGATAGTT TTAACGCTAT TAACGAAATG ATCAAAAACG CTCAAGCCGT TTTAGAAAAA 120

ACCCAACAGC TTAACGCTAA TGAAAACACC CAAATCACGC AACCAGACAA TTTCAACCCC 180

TACACTTCTA AAGACACGCA GTTCGCTCAA GAAATGCTCA ATAGAGCTAA CGCTCAAGCA 240

GAGATTTTGA GCTTAGCCCA ACAAGTAGCG GACAATTTCC ACAGCATTCA AGGGCCTATC 300

CAACAAGATC TAGAAGAATG CACCGCAGGA TCAGCCGGTG TGATTAACGA CAACACTTAT 360

GGTTCAGGTT GCGCGTTTGT GAAAGAGACT CTCAATTCCT TAGAGCAACA CACCGCTTAT 420

TATGGCAACC AGGTCAATCA GGATAGGGCT TTGTCTCAAA CCATTTTGAA TTTTAAAGAA 480

GCCCTTAGCA CTTTAGGGAA CGACTCAAAA GCGATCAATA GCGGTATCTC TAACTTGCCT 540

AACGCTAAGT CCCTTCAAAA CATGACGCAT GCCACTCAAA ACCCTAATTC CCCAGAAGGT 600

TTGCTCACTT ATTCTTTGGA TACCAGCAAA TACAACCAGC TCCAAACTGT TGCGCAAGAA 660

TTAGGCAAAA ACCCCTTTAG GCGCATCGGC GTGATTAACT ATCAAAACAA TAACGGGGCG 720

ATGAACGGCA TCGGCGTGCA AGCGGGCTAT AAGCAATTCT TTGGCAAAAA AAGGAATTGG 780

GGGTTAAGGT ATTATGGTTT CTTTGATTAT AACCATGCTT ATATCAAATC TAATTTTTTT 840

AACTCGGCTT CTGATGTGTG GACTTATGGG GTGGGTATGG ACGCGCTTTA TAACTTCATC 900

AACGATAAAA ACACCAACTT TTTAGGCAAA AATAACAAGC TTTCTGTGGG GCTTTTTGGT 960

GGCTTTGCGT TAGCCGGGAC TTCGTGGCTT AATTCCCAAC AAGTGAATTT GACCATGATG 1020

AATGGCATTT ATAACGCTAA TGTCAGCGCT TCTAACTTCC AATTTTTGTT TGATTTAGGC 1080

TTGAGAATGA ACCTCGCTAG GCCCAAGAAA AAAGACAGCG ATCATGCCGC TCAGCATGGC 1140

ATGGAATTGG GCGTGAAAAT CCCCACCATT AACACGGATT ATTATTCTTT CATGGGGGCT 1200

GAACTCAAAT ACAGAAGGCT CTATAGCGTG TATCTCAATT ATGTGTTTGC TTAC 1254

(2) INFORMATION FOR SEQ ID NO: 189: (l) SEQUENCE CHARACTERISTICS

(A) LENGTH 489 base pairs

(B) TYPE nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

( i) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE. NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...489

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 189:

GCTTTATCGC GCTGTCTTAG CGATCGTTTT AATCAGTATC CTGCCCTACA AAAAACCGAA 60

CACCATTTCG TGGATTTTTT AAACCAGGAC AAGCATTACG CCATTATCCA AAGAGCGGAT 120

AAAAGCATTT CCAGTAATGA AGCGTTGGCT CGTTCGCTCA TTGGGGCGTA TGTGTTAAAC 180

CGAGAGAGCA TTAATCGCAT TGACGATAAA TCCCGCTATG AACTGGTGCG CTTGCAAAGC 240

AGCTCTAAAG TGTGGCAACG CTTTGAAGAT TTGATTAAAG CCCAAAACAG CATCTATGTG 300

CAAAGCCATT TAGAAAGAGA AGTCCATATC GTCAATATTG CGATCTATCA GCAAGACAAT 360

AACCCCATTG CGAGCGTGTC CATTGCGGCT AAACTTTTGA ATGAAAACAA GCTCGTGTAT 420

GAAAAGCGTT ATAAAATCGT ATTGAGCTAT TTGTTTGACA CCCCGGATTT TGATTACGCT 480

TCCATGCCC 489

(2) INFORMATION FOR SEQ ID NO: 190:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 582 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...582

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 190:

TCCTTTAAAA AAAATGAAAG GTTATTGTTG CTTGTTTCTC GCTTTTTAAA CGCCATTGAT 60 CCTTTTAATT TAGGGGTGTT GTTGAGCCGT TTCCAAATTA AAAATGGTTG TATTTATGGG 120 GTGTGTTCTT ACAAGGTTTC AAAATTTACC CCTGGATATG AAGAAAGCAA AGCGCGAGTT 180 TTAAACGCTC TCAATATTTT AAGCAAGCAT CAAATTTGGC AATCCAATCA AGAAAGCGTT 240

ACAAAAGTCA AAGGAACTTT TGTTTTCATT TTAGAAAATG ACCTGCATTT AGACGAAAAC 300

TCTTTTTATA AGAAACTTTT AAATCTGATT ATAGACAATG ACTTTTTTAA CCGCTCTCAT 360

TTAGTAACTC CGAGCAATGG CACCAACTCC CACCCTGAAT TGCACCGCTC TATCACGCCC 420

AGAGAAGCCG CTAGGATACA AAGTTTTAGC GATGATTATA TCTTTTATGG CAATAAAACG 480

AGCGTTTGCA AGCAAATCGG TAACGCCGTG CCTCCTCTTC TAGCCCTAGC CTTAGGCAAA 540

GCGATCTTAA AAAGCGCAAG AAATGATACA AATCCATCAC GC 582

(2) INFORMATION FOR SEQ ID NO: 191:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 495 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...495

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 191:

ATGCAGGATA ATTTAGTGAG CGTGATTGAA AAACAAACCA ATAAAAAGGT GCGTATGTTA 60

GAAATCAAAC CTTTAAAATC CAGCCAGGAT TTAAAAATGG TCGTTATTGA AGATCCGGAC 120

ACTAAATACA ATATCCCGCT TGTAGTGAGT AAGGATGGTA ATTCAGTCAT AGGGCTTAGC 180

AATATCTTTT TTAGCAATAA AAGCGATGAT GTGAAATTAG TTGCAGAAAC CAATCAAAAA 240

ATCCAAGCCC TTAACGCTAC CCAGCAAAAC AGCGCGAAAT TGAACGCTAT TTTTAATGAA 300

ATACCGGCTG ATTATGCGAT AGAGTTGCCC TCTACTAACG CTGAAAATAA GGATAAAATC 360

CTTTACATTG TTTCTGATCC CATGTGCCCG CATTGCCAAA AAGAGCTCAC TAAACTCAGG 420

GATCACTTAA AAGAAAACAC TGTGAGAATG GTTGTAGTGG GGTGGCTTGA AGCAATTCGG 480

CTAAAAAAGC GGCTT 495

(2) INFORMATION FOR SEQ ID NO: 192:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 345 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori (ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...345

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 192:

ACGGGAGCAA TCATGTTATC TTCTAATGAT TTGTTTATGG TCGTTTTAGG GGCGATTTTA 60

TTGGTGTTGG TGTGCTTGGT GGGGTATTTG TATCTTAAAG AAAAAGAGTT TTACCATAAA 120

ATGAGGCGTT TAGAAAAAAC TTTAGATGAA TCCTATCAAG AAAATTATCT CTATTCTAAG 180

CGTTTGAGAG AATTAGAGGG GCGTTTGGAA GGCCTTTCTT TAGAAAAAAG CGCTAAAGAG 240

GACAGCTCAT TAAAAACGAC TCTTTCGCAC CTTTATAACC AGTTGCAAGA AATCCAAAAA 300

TCCATGGATA AAGAGCGCGA TTACTTAGAA GAAAAAATCA TTACT 345

(2) INFORMATION FOR SEQ ID NO: 193:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 972 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...972

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 193:

GAAAGGAAAA AAATGAACAC TAATTTAAAG AAAGCCTTGT TTTTAACTAC TCTTGGTTAT 60

TTGCAAGCTA ATGAGGGCTT TTTAGCCATT ATGCCTGATG AAAATAAACA AGAAGACATT 120

TCTCAAGAAC AGAAATTAGA ACACAAAATG GAGCAAAAAA TTGCTCCACA AAATACCCTT 180

AAAAAGCAAC AATCAGCTCC TTTACAAAGT GCTGAGTTGT TACAAAGTCA AGTTAAAAGA 240

GAAGTTAAAG AGCAAAAAAA GTCTCAAAAA CACCTAGTAG CTATGCAAAC TAAAAATGGC 300

TTTTTCTTAG GCTCAGAAAT TGCTATTACA GGCACAAGTT TAAAACAAAG TTTAAGCCTT 360

ATTTCTAATG CTACAGATGA TTTACTCACT TATAGCAAGA CTTCTAAAAA CGCTAATTTT 420

AATATGGGAC TATTAATAGG TTATCAGCAT TATTTTGGAG CTAGTAAAAG GCATGGGATT 480

AAAATCTCAA GCCATTTGTA TGGAGGCACA CCTAGTGATG TAAGCACAGA CATAAAAATT 540

TACAAATCTA AAGTTAGCAC CAATTACACG CCTTTAAATT TTGGCATAGA TGTGAAGTAT 600

TTGTTTGATT TTTTAAATGT CATTAAAAAG AACCGCCATA CACTAGGATT AAGTGTGGGC 660

TTTGGCTGGC GTATGCAATA TTATTTTGCA AAAATAGACC CCATAAAAAC CAGCCATAGT 720

GAGTTTATCA CTAATAAACC TAAAGATATT TTTAATCATG GTTTTTATCC CACTATTGGA 780

CTACATTATT ACTTAAACCA TCATCAATTT GAAGTGAATT ATCGCTTTGG AGGAGCAATT 840

AACTATCAGT CAGTTGTGCC TAGCAAAATT GTCGTTCAAA ACGGGAATTT TAAGGGCGAG 900

GTCTTGTTTT CTAATTTTCT TACCAAAGCG ACTAATTCTA GCTACATAGC GTTCAACTAC 960

GCTTATTTAT TT 972

(2) INFORMATION FOR SEQ ID NO: 194: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 411 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...411

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 194:

GCTAACGAAA AAATGGAGTT AATTAAGAAA TTGGAAAAAG AAAGCGAAGT TTTAAAGAAA 60

GATTTACAAC AACATTCAAA CGAGCTTTTT AAAATGTTGA TTATTGATAA TGAAGATTTG 120

TTTAAAGAGC AATTTGAGAT TATGTTTAAA GCATGGGTTG AAATCGTAAA AATGATGTTT 180

GAATTAACCA AAAAAACCAA ATTTGATGGC GAAATGATTG GCTACACAGA AGAACTTTTA 240

ACCTTTTTAG TTAGAGATTT TTTTAATGGG ATTTTTAAAT CCAAAGTAAT ACCTAAAATG 300

CCTATTTTTT GCGGTGATGT TAAATGCGAA GATTTTAATG CCCTAAGAAG TTTAGTTTAT 360

CTTTCTGTGC TTGAGTTGGA AGAAACGATA AATCCTAATA AAATCCCATT T 411

(2) INFORMATION FOR SEQ ID NO: 195:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 681 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(i ) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...681

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 195:

AATAAGGAAA ATAACATAAC CATTTGCGTT GCTAATGAAA AGGGTGGCAG TGGTAAAAGC 60

ACGCTTTGTT TAAACTTAGC CGTGCAATTA CTCAAAGACA ATAAAGAAGT GGTTGTTTTA 120

GATACAGATA GCCAAAAGTC TATGGAAACT TTTGCTACAA TTCGTGCTGA AAAAGAACGC 180

CCCACTTTTA GCTTATTTAA TCGTAGTAGT GGCTTTAGCG ATACTTTAAA GCAAATGGTA 240

TCTAAGTATG AAAATATCCT TATTGATACT AAGGGGGAAT ACAGCAAAGA AACCCAAAAA 300 GCTATGCTTT TAAGTAATAT TGTGCTAGTG CCAACAACTC CTAGCCAATT AGACACTGAA 360

GTCTTAGCTA ATATGCTAGA AAGAATTGAG CAACTCCAAG AGCTTAATGA AAATCTAAGA 420

GCCTTAATTG TCATCAATAG AATGCCTACT ATTCCTACCC TTAAAGAAAG ACAAGCCTTA 480

ATAGAGTTTA TTAAAGAAAA TAACCCTAGC GATAGGATTA CACTTTTAGA AAGCTCTTTG 540

AGTGAGCGCA TTGTTTATAA GCGCAGTGTA AGCGAAGGCT TAGGGGTCAT AGAATACAGC 600

GATAAAAAGG CTATCAATGA GTGGGTTAAT TTTTATAACG AATTAAAAAG CCATTTAGAA 660

AAAGAGAAAA TACATGCGTT T 681

(2) INFORMATION FOR SEQ ID NO.196:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 315 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(u) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...315

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 196:

CGTTCAACTA CGCTTATTTA TTTTAATTTT AAGGAGCCAA TGATGTCAGA TGAAATCACG 60

CAAGAAAACG AGTTAGAAAT TAACTCCAAT AATCAAAACC AAGAGCCAAA GGAAGTAGAA 120

AAAATGCCAT TGAATAATAT TCAAAAAGCT AAGAAATTAA AAAACCACGC CAATTTAATT 180

GTTCGACGCA CTGATGAGTT AGATAAGGTT ATCAATAAGC GTGAAAGCTT GCAAAGAGAG 240

TTTAAAAGAC GCATTAAGCA CTTGGATAAC AAGATTGAAA CGCTTAGTAA CAATATTGAA 300

GAATTAAAAA GAAAG 315

(2) INFORMATION FOR SEQ ID NO: 197:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 519 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(i ) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature (3) LOCATION 1...519

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 197:

TCTATGAAAA AATATCAAAA CAAACGAAAG CTGGGTAAGC GTATCAATTG CTTTATTTCA 60

AATGAATGTA AGGACATTTT AGAAAATTAT TTAAAAGTCA AAAAAATTAG CGTTACTGAG 120

TGTATAGAAA GCCTTTTATT AGCCCTAGAC CCTAGCAAAG AAACACTAAG AGCAAGGGAT 180

TTTTATGAAA GTTTGTTTAA AGTCATCAGT CTTAACCAAC ATGTCTATAA AGAACTCATG 240

GCTAATGGTA ATAACATTAA CCAAATAGCC AAGAACACCA ACATTGCCAT TAAGTATAAC 300

AAGCCCTTTT ATTTGCAGAA TTTAGCATTC TTAGAAGAGA TTTTTAAGGT TATGGATACA 360

CTTAATAAAA ATGTAGAAGA ATGTAAAAAA ATCTCTTTGG AATTATTACT TCAAATTTAC 420

AAAGAACAAA AAAGCCAAAC AGAATTTAAC GCCATTTCAA AAATTCTCAA CGCTCTTAAT 480

GAAAAACAAT CTACTACTGA GCCAAAAAAG GACAACGCA 519

(2) INFORMATION FOR SEQ ID NO: 198:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 327 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...327

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 198:

AAATCACCTT ATCGCCATAG TATATCTTCA CAGGTTTCTG TAGAAAACGA TGAGGAAATT 60

ATTGAAGTTG AAAAGGGCGA AAATCAAGGG GCGTTTTCTT ACTTTTTAGG CGGCCCCACT 120

TGTTTGGCGG GGGATTTTAT GGGGAGTTTT AGCTTTGAAA CGCCTTTAAA AAGGGGCGAT 180

AAAATCGTGT TTCAAGACAT GCTCCATTAT ACGATCGTGA AAAACAACTC GTTTAATGGC 240

GTGCCACTGC CAAGCCTGGC TAAAATAGAT TCGCAAGGTT TTAAGATCCT CAAAAGCTTT 300

TCTTATGAAG ATTATAAAAA CAGGAAT 327

(2) INFORMATION FOR SEQ ID NO: 199:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 399 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...399

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 199:

GCTTTAGAGA AGAATGGGAC TGCTACTGCT AATAGCACTA GTAGCACTAG CGGTGCGACT 60

GGTTCAGATG GTCAAACTTA CTCTCAACAA GCTATTCAAT ACCTTCAAGG CCAACAAAAT 120

ATCTTAAATA ACGCAGCGAA CTTGCTCAAG CAAGATGAAT TGCTCCTAGA AGCTTTCAAC 180

TCTGCCGTAG CTGCTAACAT TGGGAATAAG GAATTCAATT CAGCCGCTTT TACAGGTTTG 240

GTGCAAGGCA TTATTGATCA ATCTCAATTG GTTTATAACG AGCTCACTAA AAACACCATT 300

AGCGGGAGCG CGGTTAATAA CGCTGGGATA AACTCCAACC AAGCTAACGC GTGCAAGGGC 360

GTGCTAGTTA GCTCCCTAAC GCTCTTTACA ACGTGCAAG 399

(2) INFORMATION FOR SEQ ID NO: 200:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 252 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...252

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 200:

CTTATAAAAG AAGCGATGAT TCCAGTTTTT GGGAGTGAAA CAGGGATTTA TAACCATAAG 60

GAGCAAAATT TTAAAGGCAA GGGCCGTTTC ATTCTCACTT CAAAGGACAG CAAGGTTGAA 120

GGGCTTGACA TTTCTTATTC GCATGCATTA GCTATTATTG AAGCTCAAAG CATTCAAGCC 180

AATTTGTTTT TAGATGAAAT CAAACAAAGC CAGAAAGAAA AGAAAAAATT CCCCACTTTC 240

AAAGGAGGGT TT 252

(2) INFORMATION FOR SEQ ID NO: 201:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 483 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...483

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 201:

CCCTTTCTAA AAAAGAATAA ATTTTTACAA ATTTGTCAAT ATTTTAGCGC GCATTTCAAG 60

CAAGTGTTAA AAAATGAAAA GCCCTTAGTT TATTATGGGG TTTTAAAGGC TAAAGCCCCT 120

AATTGGGCTT TATGGGTTTA TGAAAAACCC TTAAAAAAAG AAATTTACAT GAACGATAAG 180

GAAGTGGTGG TTTATGAGCC TAATTTATTC CAAGCGACTA TCACGCCCTT AAAAGACAAG 240

ACGGATTTTT TCACCATTCT CAAGCAATTG AAAAAGCAGA CTGACGGCTC TTTTAAAACG 300

ACTATCAACA AGACCACTTA TCGTTTGGTT TTTAAAGACG GCAAGCCTTT TTCGTTGGAA 360

TTTAAAGATG ACATGAATAA TCTTGTTACG ATCACTTTTT CTCAAGCAGA AATCAACCCT 420

AAAATTCCTA ATGAAATCTT TGTTTTTAAC CCTAAAGATG AAAATATTGA TATTGTACGC 480

CAG 483

(2) INFORMATION FOR SEQ ID NO: 202:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 213 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...213

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 202:

CCTAGCTTTT TGAAAGAAAA ATTTGATTTT TTTAAAGGCA AAAATTTTAA AATTGTCTAT 60

TGTATTGGCG AAGATTTAAC GACCAGAGAA AAGGGTTTTA GGGCTGTAAA GGAATTTTTA 120

AGCGAGCAAT TAGAAAATAT TGATCTTAAT TATTCCAATT TAATTGTGGC TTATGAGCCT 180

ATTTGGGCGA TTGGCACTAA AAAAGCGCGC TTT 213

(2) INFORMATION FOR SEQ ID NO: 203:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 465 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double (D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...465

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 203:

CGCGATGTTA GATTCCATGT TAGGGACCTA GTTCGGCAAC TCAAGGGCAA GCATTTGATT 60

GAAGTTTCAG ATGTGATTAA CGACACCACT CAGCCCAATT TGGACATGAA TCTTTTGACG 120

ACCGAAATCG CGCGGCAGTT GCGATTGCGA TCTAATGGGA GGTTCAATAT CACAAGGGCG 180

AGTGGAGGGA GTGGTATTGA AGCAGACAGC AGAATGGTGA AACAGCGCGA AAAAGAACGA 240

GAGAGCGAAG AGTATAATCA AGACACCACT GTAGAAAAAG GCACTTTAAA AGCCGCTGAT 300

TTATCTTTAA GTGGTAAAGT ATCCAGTATC GCAGCCTCTA TTAGTAGTTC TAGGCAACGC 360

TTAGACTACG ACTTCACCCT AAGCCTTACC AATAGGAAAA CGGGTGAAGA GGTATGGAGC 420

GATGTTAAGC CTATTGTGAA AAATGCTAGC AATAAGCGTA TGTTT 465

(2) INFORMATION FOR SEQ ID NO: 204:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 657 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...657

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 204:

ATTAAATCTG TTTTAGGTTT AATTTTGATC CAACAAAATT TTAAAACACT TAAGGAGTTG 60

TATATGTTAG TTACAAAACT TGCCCCCGAT TTTAAAGCGC CTGCCGTTTT AGGAAACAAT 120

GAGGTTGATG AACACTTTGA GCTTTCTAAA AATTTAGGCA AAAATGGTGT GATCCTTTTC 180

TTTTGGCCAA AAGATTTTAC TTTTGTATGC CCTACAGAAA TCATTGCGTT TGACAAAAGA 240

GTGAAAGACT TCCACGAAAA AGGCTTTAAT GTGATTGGCG TGTCTATTGA CAGCGAACAA 300

GTGCATTTCG CATGGAAAAA CACCCCTGTG GAAAAAGGCG GTATCGGTCA AGTGTCTTTC 360

CCTATGGTGG CTGATATCAC TAAGAGCATT TCTAGAGACT ATGATGTGCT GTTTGAAGAA 420

GCGATCGCTT TGAGAGGTGC TTTTTTGATT GATAAAAACA TGAAAGTAAG ACACGCAGTG 480 ATCAATGACT TGCCATTAGG TAGGAATGCA GATGAAATGC TTCGCATGGT AGACGCTCTC 540 TTACACTTTG AAGAACATGG TGAAGTATGC CCAGCAGGTT GGAGAAAAGG CGATAAAGGC 600 ATGAAAGCAA CTCACCAAGG CGTTGCAGAG TATCTTAAAG AAAATTCCAT TAAGCTT 657

(2) INFORMATION FOR SEQ ID NO: 205:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 339 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...339

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 205:

GGAGTAATAA TGGAACACCA TAAAGCGCAC ACAACCATTC AGGCTTTACA AGCCAAACGC 60

AAAAGGTTGC TAACCGAATT AGCCGAGTTA GAAGCAGAAA TAAAGGTGAG CAGCGAACGA 120

AGGAGCAGTT TTAACGTTTC GCTCTCGCCG AGTTTGTTAG CCGAAATAGA AGAGATAGAA 180

TACGAAGAAA AAATGAGCAA AGAGCGAAGA ATCCATCACA ATCTTTTGCT TTCGCCCAGT 240

TTCATGGCTA AAGTGGATGA ATACATGAAA GAGAAAGGTT TTCCTAATCG ATCGCTTCTC 300

TTTGAAAAAG CGTTGGAGTT TTATATGCTA AAACACCCA 339

(2) INFORMATION FOR SEQ ID NO: 206:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 561 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...561

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 206: GGTTTTGTTT GCGGTAGCGT TTTATTTCAA TTAGGAGTTT TTATGGGGTT AAAGAATAAA 60

ATCAAGGGTT TTGTTAAAGA GAGAATGCCT TTTGTAATGA GATGCGTTCG TGGTTTAAAA 120

GGGGCCAAAG ACACCCATGA AAACGCCCAT GATAGGGACG CTTATTGTGG AATCAATCGT 180

GAAATTAAGG AAATGCTAGA GGCTAAAAAA CTTCATTTTC TTCAAGAAAA AGCTTTATTC 240

AACCACGACC ATCAAGAAAG CGTGTTTTTA GCTATCGCCT CTTTAAATAA TGAAAGTTTC 300

ATTGAATACA ACAAGAGTAT TTATAAAAAT AGTTCTCTTA ATTATAATTA TGGGGGGCAT 360

TTAGAAGATA GGGTCATCCA TCCCACTTTA ACTTTACCCA ATCCCACGCA TTCGGGTTAT 420

TTTGACTATG ATAAAAAAAG TCAAAACCCT AAAAGCCCTC TAAACCCATG GGCTTTTATT 480

AGAGTCAAAA ACGAAATCGT TACTTTAGAA GAGAGTTTGT TTTCTATGCT TCCTGCCGTT 540

CAAAGGGGGG GTCATTGGTT T 561

(2) INFORMATION FOR SEQ ID NO: 207:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 690 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...690

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 207:

AAGAGAGTTT GTTTTCTATG CTTCCTGCCG TTCAAAGGGG GGGTCATTGG TTTTAATGAT 60

TGCGATGATG GCTCTAAAGA AGTGGTTTTA GAGTTTTGCA AAAAGTTCCC CTCATTTATC 120

CCTATCAGCT ATCCTTATGA AGTCATACTA AAGGATTGTC CGAGTTTGTG GCACCAACTC 180

TATCATTACT GTAATTATAC GCTTTCTTTT ATCCCTAAAA ATGAGTGGGT AGTAAAAATT 240

GATTGCGATC ATATCTATGA CGCTAAAAAG CTTTATAAAA GTTTTTATAT TCCTAAGAAT 300

ATTAAAGAGG TTGTGATGTA TTCGCGCATT AATTTTGTGG TGCGAGATTT TGAAGTGTTT 360

GTTCGTAACG ATGGGGATTT TGGGTTTTTA GACGCATGGG GGGATCATTG GTTATTGTAT 420

AACGATTGCG AGCCTTTTGA AATTTGGCGC TACAATGATG AAAGTTATGA AGTCCTAAAG 480

CTTAAAGATA AACACCATAT TAAAGATAAG GAAATGGTGC AATGGCACTT CCCTTTGGCT 540

AAAAAGAGGC GAAACGCTAT TGTTTATGAC GATTTGATCC CTTTAGAAGA ATTCAAAAAA 600

CGCCATGCCG ATTTGATAGG CACAAGGATT GAAGAAAGCA TGCTAGATGA AAAGAGGATT 660

TTAGAGGTAT ATCAAAAATT CCGCTTGCCT 690

(2) INFORMATION FOR SEQ ID NO: 208:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 258 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (ill) HYPOTHETICAL NO

(iv) ANTI-SENSE- NO

(vi) ORIGINAL SOURCE

(A) ORGANISM. Helicobacter pylori

(ix) FEATURE

(A) NAME/KEY mιsc_feature

(B) LOCATION 1...258

(xi) SEQUENCE DESCRIPTION. SEQ ID NO.208.

CTAAGTTTAA ATAAAAAAAT GATGTTTGAA TTAACCAAAA AAACCAAATT TGATGGCGAA 60

ATGATTGGCT ACACAGAAGA ACTTTTAACC TTTTTAGTTA GAGATTTTTT TAATGGGATT 120

TTTAAATCCA AAGTAATACC TAAAATGCCT ATTTTTTGCG GTGATGTTAA ATGCGAAGAT 180

TTTAATGCCC TAAGAAGTTT AGTTTATCTT TCTGTGCTTG AGTTGGAAGA AACGATAAAT 240

CCTAATAAAA TCCCATTT 258

(2) INFORMATION FOR SEQ ID NO: 209:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 492 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...492

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 209:

TTTTCAAGAA AGACAGACAA AAACGCTCAA AAAGACGAGC AAAAAAATGA ACAAGAAGAA 60

CAAAGGCGTT TAAGAGAGCA ACAACGCTTG AAACAAAACC AAGAAAACCA AGAGATGTTG 120

AAAGGTTTGC AACAAAATTT GAATCAATTC ACGCAAAAAT TAGAAAGCGT TAAAAACAAG 180

ACTTTAGATT TGCAAATCCC TAAACAAGAT GGGGTTGATG AAAAGGCTTA TCAAGAGTGG 240

TACGCTCAAA TCTATCAAAT TTTATATAAA GGCTGGAGGG GCGTTTTTTA TCACAAGGCT 300

TCAGTGAGCG TGCTGATTAT GATCACTAAA GATGGAGAGT TTGATTATAC CATTCTTAGC 360

TACTCTGATT TTAAGGATTA TAACAAGAGC GTGATGACCC TTTTAGATGA TTTAAAGAAA 420

GTGGATTTCC CCCCATATCC TGGAGGAAAC ATGATTTCTA TTAAAGTTAA TTTTACGACT 480

AAGGAAGAAC AA 492

(2) INFORMATION FOR SEQ ID NO: 210:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 204 base pairs

(B) TYPE: nucleic acid (C) STRANDEDNESS double

(D) TOPOLOGY circular

(11) MOLECULE TYPE. DNA (genomic)

(m) HYPOTHETICAL NO

(iv) ANTI-SENSE NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY mιsc_feature

(B) LOCATION 1...204

(xi) SEQUENCE DESCRIPTION- SEQ ID NO: 210:

AGAGCGCGAT TACTTAGAAG AAAAAATCAT TACTTAGAAA ACAAATTTAA AGACATGGGG 60

CATTATGCCG CTAGCGATGA AGTCAACGAA AAACAGGTTT TGAAAATGTA TCAAGAAGGC 120

TATAGCGTGG ATTCTATTTC TAAAGAATTT AAAGTGAGTA AGGGCGAGGT GGAATTTATA 180

TTGAACATGG CAGGGTTAAA ATGG 204

(2) INFORMATION FOR SEQ ID NO: 211:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH. 291 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...291

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 211:

ACGAAATTGG ATACAATCAG CTTAAAAAGG ATACAAATGG AAAAATTACC TAAAAAACGA 60

GTTTCTAAAA CCAAATCACA AAAACTTATC CATAGCCTAA CCACCCAAAA AAACAGAGCC 120

TTTCTCAAAA AAATCAGCGC TAATGAAATG CTTTTAGAGT TAGAAAAAGG GGCGTTTAAA 180

AAAAATGAAG CCTATTTTAT TTCTGATGAA GAAGATAAAA ATTACGTTTT AGTGCCGGAC 240

AATGTGATCT CTCTTTTGGC AGAAAACGCC AGAAAGGCTT TTGAAGCCAG G 291

(2) INFORMATION FOR SEQ ID NO: 212:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 816 base pairs

(B) TYPE: nucleic acid (C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...816

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 212:

AGGAGTATTA AAATGAAACA AAGTTTGCGC GAACAAAAAT TATTGAAAAT TTTGGAAAAT 60

GATGTCTTGA CGATTTTGGA TAGTTTTTCT AATTACCTTT TTGAACTGAG AGAAGAATTG 120

GACTTCATAG AAGAAGAAAT GGAAGGTGAA ATCACTGAAC AAAACCTTAC CGCTCTTTAT 180

GATTTTTCTA ATTTCTTAGA AGACCATGTC AATGTGTTTT ATGAGAATGT TTTGAATATA 240

GATGATGTCA AAACAGAACA CCTTTATTCA GGTCTCATAG ATAGTCTTAA CGCTAATCTT 300

CACTTTGTCA AGTCATTTCT CAGTAATCAG GATTTAGACT TCCGCTTTTT TAAAGAAATA 360

AACGATGGGC AAGATCCCCA AAAAACATTA TCAAGATTGA TTCCTCTTCA AAGTGGGAAG 420

AATGATGCAA GCTCGTTTAA AGCCAATAAT TCTTTTGTTT CATTAGTTTA TGTTTATGCT 480

TACTTCATGC TAGAAACTAT CAGGCAGTCG TATAGGATTC TCAGATTACT AGAAAAACCT 540

ATCAATAACA ACATAAGCGA GGACATGCAG AGCGATATAG AGAATTTTTT TGTTCAAGCA 600

AATTTTTTAG AATACTATGT TCAGAACAAA ATATACCCAA CCAATCATGC CTATGACTTC 660

ACGCATTTGA TCATGGACTC CATTATTCCT AATTGGATTC AGATTGATAT GAGCGTTGAA 720

GCTAAAAAGA AAGAGCTTTT TGAAAAATAT TTTCAAAACA TTGATGAAGT AACAAACAAA 780

ATGCTCGCTC AAGAAAATCA AAACAAAAAC AGCGAT 816

(2) INFORMATION FOR SEQ ID NO: 213:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 687 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...687

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 213: GTGAAAGGCG AGAAAAACGC TTGGTATCTG GGGATTAGCT ATCAAGTCGG TCAGGCTTCA 60 CAAAGTGTTA AAAACCCCCC CAAAAGTAGT GAATTTAACT ATCCTAAGTT CCCTGTGGGT 120

AAAACCGACT ATCTGGCCGT TATGCAAGGC TTAGGGCTTA CTGTGGGTTA TAAGCAGTTT 180

TTCGGGGAGA AAAGATGGTT TGGTGCGCGC TATTACGGCT TTATGGATTA TGGGCATGCC 240

GTGTTTGGAG CGAACGCTTT GACATCAGAT AATGGTGGGG TGTGCAAACT CAATGAGCCA 300

TGCGCGACCA AAGTAGGGAC TATGGGCAAT CTGTCTGACA TGTTCACTTA TGGTGTGGGT 360

ATTGACACTT TATACAATGT CATTAATAAG GAAGACGCGA GTTTTGGTTT CTTTTTTGGG 420

GCTCAAATCG CGGGTAACTC TTGGGGTAAT ACGACAGGGG CCTTTTTGGA AACTAAAAGC 480

CCTTATAAGC ACACCTCCTA TAGCCTTGAT CCGGCGATTT TCCAGTTCCT TTTTAATTTA 540

GGGATTCGCA CCCATATTGG TCAGCATCAA GAATTTGACT TTGGCGTGAA GATTCCTACT 600

ATCAATGTTT ATTATTTTAA CCATGGGAAC TTGAGCTTCA CTTACCGCCG TCAATACAGC 660

CTTTATGTAG GGTATCGTTA CAATTTC 687

(2) INFORMATION FOR SEQ ID NO: 214:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 195 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...195

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 214:

AGCGCTGTAG TGGAGAGCGT GGTTATTTTA AAGATTGACA TCAATCAGGG GCGTTCTTGC 60

TCGCTCTACC CCACGCCTAA AAGCGTTTCT TTAGTGAGGA ATCAAAGCGT AGCCTATGAA 120

ATTTTATGCG AAAACCAGCC GCTATGGATA GAAGTTAGCA CCAATTTAGG GCAAACGCTA 180

CCTTTCAGTT TAATT 195

(2) INFORMATION FOR SEQ ID NO: 215:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1095 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori ( ix ) FEATURE :

(A) NAME/KEY: misc_ eature (3) LOCATION 1...1095

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:215:

CGCTTTAAAC ACTTTAGGGG TGGGGGTTTT CCCCACCACA ACCTCAACGC ATGTGGTGCT 60

AAACCCACCG GACAAGTCGT ATTCTATCCA ACTAATTCCC TTTTAGGCTC TACTTCTTCA 120

AACAGCAATA ACCAACAACA ATACAACAAC ACCCTTTTAA TGAACACCTT ACAAGGGGAA 180

TTAAGCACTA ACAATCAAAA TAACCCCAAT GGTTGCGCCA ATCAAATCCA GTGTTTAGAG 240

CAATTCATCC AAAATTTAAC CCCTTTAGCC GCAACCCCCA CTTCAACTAA CCAGGCCAAC 300

CAGCAAGTCC AAGCCATCGC TCAAAAACTT CAAAGCGTTG CTATCAACGC TTTAGACAAC 360

AATGCGATCA ACAACACCAC CTATAATTTA AACAACTTGC ACAACGCTTT GAATTTCCAA 420

GCCTATCAAA GCACGATAGA ACAATACAAT AACGCTTTAA AGCAAATTTC GTGGATTAGT 480

TTTAGCGAGC CTAAAAACTT GCTCAAAAAC ACTTCCAATA ACTACCAAAT CGGCACGGTT 540

ACCAACGATC AAGGGCAAAA TATCAGCGCC TATGATTGCA CAAGCGCTAC CGGAAGCCTT 600

TCTAGCGATG CTTCTAGTGG GATTTCATGC TCAGCCACAA GCTCCACAAG CAACACAAAT 660

AGTTTTGACA ATTCTTTAGT CGCTACCTCC AAAGTCCAAA CCATCAACGG CAAAGAGCAG 720

ATCGGCGTGA ATTCTTTTAA TCTTGTCTCT CAAGTGTGGA GCGTTTATAA CTCTTTAAAA 780

ACTTCAGAAG AAAATTTGCA AAAAAACGCC AAAATATTAT GCAACAATGG ATCGCAATCT 840

GGGACAAGCC CATGCAATAG CTCTTCAGGG GGTTTGAGCA TCAGCGGGAA CGCCCAATTG 900

CAAAATATTT TAAGCCCTAC TAATGGGACT ACCACTAATA CTCAAGCTAA AAGCAACGCT 960

TCCAAACTAA AAGCGATGGT AATGGTGAAT AATGAAGAAG AAGCCAAAAC GACCAATTTC 1020

AATCAAAGCA GTGGGCCAAC CACACAATCT TCTAACAGCA CGGTGATGGG AGCTTTAAAC 1080

ACCGTATTGC AAAAT 1095

(2) INFORMATION FOR SEQ ID NO: 216:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 405 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...405

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:216:

AACCCATTCT TCACAATCAC AGCCAAACTC CTTTCCAACA CCCAAAGCGC GTTTGATCAG 60

GGCATCGCTC TAAGCTCTAA TATCATTAGT GCAGTCAATA GCCTAAACCC TAGCAACAAC 120

TCCCAAGAAG TCAAAGCCCA GCTCCAAAAC ACCGCGCAAT CCATGACAGA ATTGTTGCAA 180

CAAATTGAAC ACAGCATCAC TAAAACCACT AGCACCACTT ACGCACAATC CTTACTCTCC 240

AATCTGACCG ATGCGGTGAA TGCATCTAGC AATAATACCA CTTATGTGAG CGCTCTTGTT 300

AACGCTTTAA ACACTTTAGG GGTGGGGGTT TTCCCCACCA CAACCTCAAC GCATGTGGTG 360

CTAAACCCAC CGGACAAGTC GTATTCTATC CAACTAATTC CCTTT 405 (2) INFORMATION FOR SEQ ID NO.217:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH 273 base pairs (3) TYPE nucleic acid

(C) STRANDEDNESS. double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE- DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...273

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 217:

GGAAGAGGAA TGAAATTAAA AAAACGAAAA GTTGCGGCTA CATTGCTAAA GCGTTTGACC 60

TTGCCACTAT TGTTCACTAC GGGTTCATTA GGGGCGGTTA CTTATGAAGT GCATGGGGAT 120

TTTATCAACT TCTCCAAAGT GGGTTTTAAC CGTTCGCCTA TTAACCCTGT TAAAGGTATC 180

TATCCTACAG AAACTTTTGT TAACCTTACG GGTAAGCTAG AGGGGTCTGT GCATTTAGGT 240

AGGGGATGGA CCGTGAATGT AGGCGGTGTT TTG 273

(2) INFORMATION FOR SEQ ID NO: 218:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2163 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...2163

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:218:

ATGGAGCAGC CAGTCATTAA AGAAGGGACT TTAGCTTTAA TTGATACCTT TGCGTATTTG 60

TTTAGAAGCT ATTACATGAG CGCTAAAAAT AAGCCTTTAA CCAACGATAA GGGCTTTCCT 120

ACAGGGCTTT TAACGGGGCT TGTGGGCATG GTTAAAAAAT TTTATAAAGA CAGAAAAAAC 180

ATGCCTTTTA TCGTGTTCGC CCTAGAAAGC CAGACTAAAA CTAAAAGAGC TGAAAAACTG 240

GGCGAATACA AACAAAATCG TAAAGACGCC CCTAAAGAGA TGCTTTTACA AATCCCTATC 300 GCCTTAGAAT GGTTGCAAAA AATGGGTTTT ACTTGCGTGG AGGTGGGAGG GTTTGAAGCC 360

GATGATGTGA TCGCAAGTTT AGCCACGCTA AGCCCTTATA AAACCCGCAT TTATTCTAAA 420

GATAAGGATT TTAACCAGCT TTTGAGCGAT AAAATCGCGC TTTTTGATGG CAAAACGGAG 480

TTTTTGGCGA AAGATTGCGT GGAAAAATAC GGGATTTTGC CGAGTCAATT CACGGATTAT 540

CAGGGCATTG TGGGGGATAG CAGCGATAAT TACAAGGGGG TTAAAGGCAT TGGGAGCAAG 600

AACGCTAAGG AATTGTTGCA GCGATTAGGG AGCTTGGAAA AAATCTATGA AAATTTAGAC 660

TTGGCGAAAA ATTTACTCAG CCCTAAAATG TATCAAGCCT TGATACAAGA CAAAGGAAGC 720

GCCTTTTTAA GCAAAGAATT AGCCACTTTA GAAAGAGGAT GCATTAAAGA ATTTGATTTT 780

TTAAGTTGCG CTTTTCCGAG CGAAAACCCC TTGTTGAAAA TCAAAGATGA ATTGAAAGAA 840

TATGGTTTCA TTTCTACCTT AAGGGATTTA GAAAATTCCC CTTTCATTGT AGAAAACGTG 900

CCCATATTAA ACAGCACGCC TATATTAGAC AATACCCCCG CCTTAGACAA CGCCCCTAAA 960

AAATCGCGCA TGATTGTTTT AGAAAGCGCT GAGCCTTTGA GCATGTTTTT AGAAAAATTA 1020

GAAAACCCTA ACGCTAGGGT TTTTATGCGT TTGGTTTTGG ATAAAGACAA AAAAATTCTA 1080

GCCCTAGCGT TTTTATTACA AGATCAAGGC TATTTTTTAC CTTTAGAAGA GGCGTTGTTT 1140

TCGCCCTTTT CTTTGGAATT TTTACAAAAC GCTTTTTCTC AAATGTTACA GCATGCGTGT 1200

ATCATTGGGC ATGATTTAAA GCCTTTATTA AGCTTTTTAA AAGCCAAATA TCAGGTGCCT 1260

TTGGAAAATA TCCGCATCCA AGACACTCAG ATTTTAGCGT TTTTAAAGAA TCCGGAAAAA 1320

GTGGGGTTTG ATGAGGTTTT AAAGGAATAT TTAAAAGAAG ATTTAATCCC GCATGAAAAG 1380

ATCAAAGATT TTAAGACAAA AAGTAAGGCG GAAAAATCAG AACTTTTAAG CATGGAATTA 1440

AACGCCTTAA AGCGTTTGTG CGAATACTTT GAAAAAGGGG GGCTAGAAGA GGATTTGCTC 1500

ACTTTAGCTA GAGACATTGA AACGCCGTTT GTGAAAGTTT TAATGGGCAT GGAATTTCAA 1560

GGCTTTAAGA TTGATGCCGC CTTGGAAAAT ATCGTCATCG CAGGTGTTAC AAACAAACCC 1620

AATGGTGCTG GCGCTATCAC ATCCACTGGT CATGTAACCG ACTATGCGGT GTTTAACAAC 1680

ATCAAGGCGA TGCTACCTAT CTTGCAACAA GCGCTTACGC TTTCTCAAAG TAACCACACC 1740

CTATCCACTC AGTTGCAAGC TCGAGCTATG GGATCTCAAA CAAATCGTGA ATTCGCTAAA 1800

GACATCTACG CTTTAGCTCA AAACCAAAAG CAAATCCTTT CTAACGCTTC AAGTATCTTC 1860

AATCTCTTTA ATTCCATTCC TAAAGACCAA CTTAAGTATT TGGAGAACGC TTACTTGAAA 1920

GTGCCACATT TGGGTAAAAC CCCTACTAAC CCTTACAGAC AGAATGTGAA TTTGAATAAA 1980

GAAATTAATG CGGTTCAAGA CAATGTAGCT AATTATGGTA ATCGTTTGGA TTCGGCTTTA 2040

AGCGTGGCTA AAGATGTTTA TAACCTAAAA TCCAATCAAA CAGAGATCGT AACCACTTAT 2100

AACGATGCTA AGAATTTGGG CCCAGGGGTT TCTAAACTTC CCTGTCGTTG TTTGGAGAAG 2160

ATT 2163

(2) INFORMATION FOR SEQ ID NO: 219:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 228 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(id) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...228

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 219:

ACTTCCCTGT CGTTGTTTGG AGAAGATTTA GCCAAAGAAA AACGATCCAT CGCTAAAAGC 60 ATTAATTTTG GGCTGGTGTA TGGCATGGGG AGTAAGAAAT TGAGCGAAAC TTTAAGCATC 120 CCTTTAAGTG AGGCTAAAAG TTACATAGAA GCGTATTTCA AGCGATTCCC TAGCATTAAA 180 GATTATTTGA ATGGCATGCG AGAAGAGATT TTAAAAACTT CTAAAGCT 228

(2) INFORMATION FOR SEQ ID NO.220:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 975 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY- circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...975

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:220:

AAAGAAAAGG ATAACCCCTT GCAAAACTTT GTTTTTAATA AAAAATGGCT CATCTATTCT 60

AGCCTACTCC CCTTATTTTT TCTTAACCCT TTAATGGCAG AAGACGATGG GTTTTTTATG 120

GGGGTGAGTT ATCAAACTTC TTTGGCCGTT CAAAGGGTGG ATAACTCAGG GCTTAACGCC 180

AGTCAAGACG CATCCACTTA TATCCGCCAA AACGCTATCG CTCTAGAATC TGCGGCGGTG 240

CCTTTAGCCT ATTATTTAGA AGCGATGGGC CAACAAACGA GAGTCTTAAT GCAAATGCTC 300

TGCCCTGATC CTTCTAAAAG ATGTTTGCTC TATGCAGGGG GCTATCAAAA CGGACAAAAT 360

AATAACGGCG ATACAGGCAA CAACCCCCCA AGAGGCAATG TCAATGCCAC CTTTGATATG 420

CAATCTCTAG TCAATAATTT AAACAAGCTC ACCCAACTCA TCGGCGAAAC TTTAATCCGT 480

AACCCTGAAA ATCTTCCTAA CTCCAAAGTC TTTAACGTCA AATTTGGCAA TCAAAGCACT 540

GTTATTGCAT TGCCTGAGGG TCTAGCCAAT ACCATGGACG CTTTAAACAA TGACATCACC 600

AACGCTTTAA CCACGCTCTG GTATAACCAA ACCTTAACGA ATAAATCTTT TAGCACCCCT 660

AGTAACACTT CTGTGAATTT TAGCCCCCAA GTCTTGCAAC ACCTTTTACA AGACGGCTTA 720

GCCACAGCAA ATAATAATCA AACCATTTGC AGCACTCAAA ACCAATGCAC CGCCACTAAT 780

GAAGCTAAAT CTATCGCTCA AAACGCCCAA AACATCTTCC AGGCTTTAAT GCAAGCAGGG 840

ATTTTΛGGGG GCTTAGCCAA TGAAAAGCAA TTTGGCTTCA CTTACAACAA AGCCCCCAAT 900

GGCGGCGATT CCCAACAAGG CTATTCAAAG CTTTGCGGCC CGGGTATTAC ACCAAAACGA 960

CAACACCACG CAAGC 975

(2) INFORMATION FOR SEQ ID NO: 221:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 840 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic) (ill) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...840

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:221:

TATAACCAGA TGCAAGACGT GATCAATTAC GGGGAAAGCT TGCTTAGTAA CACCGTAGCG 60

TATGGGGATT TCATCACCAA TTGGGTCGCC CCCTATTTGG ATTTAAACAA TAAAGGTTTG 120

AATTTCTTGC CTAATTATGG GGGGCAATTG AATGGCGCTA ATAATCAAAC CCCACAATTA 180

ACCCCACAAC AAGCCCAACA AGAACAAAAA GTGATCATGA ACCAATTAGA GCAAGCCACA 240

AACGCCCCCA CCCCCGCGCA AATAAACAGG ATTTTAGCCA ACCCCTATTC CCCCACGGCA 300

AAAACTTTAA TGGCTTATGG GCTCTATCGC TCTAAAGCAG TGATTGGCGG AGTGATTGAT 360

GAAATGCAAA CTAAAGTGAA TCAAGTCTAT CAAATGGGCT TTGCTAGGAA TTTTTTGGAG 420

CATACACTCT ACATTCTAAT AACACTGAAC GGCTTTGGCG TGAAAATGGG CTATAAGCAA 480

TTTTTCGGCA AAAAGCGCAT GTTTGGGCTT AGGTATTATG GTTTTTATGA TTTTGGTTAC 540

GCTCAATTTG GCACAGAATC TTCTTTAGTG AAAGCCACCC TCTCTAGCTA TGGAGCGGGC 600

ACAGACTTTC TTTATAATGT TTTTACCCGA AAAAGAGGGA CTGAAGCGAT AGATATAGGT 660

TTTTTTGCCG GTATCCAACT TGCAGGGCAA ACCTGGAAAA CGAATTTTTT AGATCAAGTG 720

GATGGCAACC ATCTTAAACC TAAGGACACT TCTTTCCAAT TCCTTTTTGA TTTGGGCATA 780

ATGGACCAAA TTTTTCCAAA ATCGCTCATC TCAAAAAAGA ATCTCGTTTT TCTCAAGGGA 840

(2) INFORMATION FOR SEQ ID NO: 222:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 405 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...405

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:222:

CAACCACACA AACAAAGAAA CATCGCCCAT CTACAACACG CGCAAGCTGT TATCACTTCA 60

GTATTGGCTT TTTGGAGTCT TTATGCAGGG AACGCTCTCA GTTTTCATGT GACCGGTTTG 120

AATGATGGAT CTAATTCTCC TTTAGGAAGA ATCCATAGAG ATGGGAACTG CACAGGATTA 180

CAACAATGTT TTATGAGCAA AGAAACTTAT GATAAAATGA AGACACTTGC CGAAAACCTC 240

CAAAAAGCTC AAGGCAATCT CTGTGCCTTA TCAGAATGCT CTAGCAATCA AGATAGCGGA 300

TTTCCTGTTT TGGATAGTGC AGGAAAACAA GTAACTATAA CAATAACAAC GCAAACTAAT 360

GGAGCTAATA AAAGTGAAAC TACTACTACT ACTACTACTA CTAAT 405 (2) INFORMATION FOR SEQ ID NO: 223:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 372 base pairs (3) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...372

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 223:

GGACTATCAA GGCAAGGAAA TGAAAGATTG GATGCCACGC TCAATTTAAA AACCGGCGTG 60

CAAAGTTTTT TTAAAAAATA CATCGGGATT AGGGGGGTTT TTGCATGGGA TCTTGGGTCA 120

GGAAAAGTGA ATTATCAAAG CTATAAAGAT CCTACCAACT CTTTTTTTAC CATGCTTGCG 180

GTGGGTTTGG ATGTGATCAT GGAATTTCCT CTAGGGAGTT ATAAGCATTA TTTAGGGGCG 240

TTTGGGGGAG CTAGGGGGGC TTTAGTTGTT TATACAGACA AGCAAAATTT CAAGTTTTTT 300

AAACATTCTG TGGTTTCAGG GGGATTAGCG ATTAGTGGAG GTTGGTTGAT ATTGTTGCGG 360

ACACCGCACT TC 372

(2) INFORMATION FOR SEQ ID NO: 224:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 309 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...309

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 224:

CCGGTTGGGC TCTACCCCCT TGAATCCCCT TTAATTTATG AAGAAAACCA TTTGTTACCC 60 ATGGGGTTTA TCCATTTAGC CTTTAGAGGG GGTGGGAGCT TGAGCGATAA AAACCAGTTG 120 GGTTTGGCGA AATTGTTCGC GCAAGTTTTA AACGAAGGCA CTAAAGAGCT TGGCGCGGTG 180 GGGTTTGCGC AACTTTTAGA GCAAAAAGCG ATCAGTTTGA ATGTGGATAC CAGCGCAGAA 240 GATTTGCAAA TCACTTTAGA ATTTTTAAAA GAATACGAAG ATGAAGCCAT AATGCGCTTA 300 AAAGAGCTT 309

(2) INFORMATION FOR SEQ ID NO: 225:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 258 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...258

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 225:

TATAGCGTGT ATATCCGCTC CAACTTTTCT AAAGTGGCGC ATTTTGCGAG CGGGTATTTG 60

CAAACCAAGC TCAGCACTCA AGCTAAAAGC GTTGCCTTAG CCAAAAAAAC AACTAAAGAA 120

TTTATAGAAA AAGGCATGAC GCAACAAGAA TTAGACGACG CTAAAAAGTT TTTACTAGGC 180

TCTGAGCCTT TAAGGAATGA AACGATCTCA AGCCGCTTGA ACACCACTTA CAATTATTTT 240

ATTTGGGTTT GCCTTTAG 258

(2) INFORMATION FOR SEQ ID NO: 226:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1029 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1029

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 226: AGACGCGCAT GGATTCTGTT GGGTTTGAAG AATCTCAAAG GGGTTTGGGT GCTTAAGGGG 60 TTAAAAAAAG CGTTTAAGGA GAGGTTTTGC TCTCAAGTGT ATATCTCTTT TAATGTGGAT 120

CACAATCTTT TATCCGCTCA AGTTTTAAGG GTTAAAAACC ACCGCATCAA AGAGAAATTT 180

TTTAAAACTT TTGAGACTAA AGTGGAAACT AAAAATGGTG AAGTCCCCAT TCAAGCCTTA 240

AAAATCGCCA GAACTTATAG CCAAAAATAC CCCTACACCT ATTTTAGCGC GATGAGTAAA 300

GCTAAAGAGG TTTTATGCGA AAAGCAGGCG TTTGAACAAA TCAAACAAGA AAATCAAGAT 360

TATCAGGCTT GTGAAGTCAA TCAAAAGTAT TGCGTTTATG TGGAATCTAA GGATTTTCTA 420

AAGGATTTCA AGCGTTTTAA AATCCAGGAT GTGGATTTTT TGTTTTCGCC CTTTAGCCTT 480

ATTTATGATT TTGTGCGCGA TAATTTAGAA AACAAGCCGT TGTTGTATCT GCTTTTAGAG 540

CGTTCAAGGT TTTATTTTTT GATTGCGGAT AAAAAAGAGA TTTTTTTAGC CAAATCCGTG 600

TTTTTAGAAG AGCAACCTGA AGAGTTTATA GAGAGCAAAG AAGAAGATTC TATGGGAATG 660

GATAATGAAG CTGTGGATTT GTTTTTGAGT GAAATCCAAG AAGATATTGA CAGCCTTGAA 720

GAAGCGATAG GCCTAGACAG CAGCAAGGAT AATAGCGAAA AAATAACAGA GGACGCTTAT 780

AGTTTGATTG AAGGCATGAC GAATATCCCC TTGATTGCAG ATGTTTTGCA AGAGGGATTG 840

CGTGGCGTCT ATCATTCTAG AGAGATAGAC TTTGTAGAAA AAGTGGTTGT TTTAGACAGC 900

TGTCAAATCC ACCACAAGGC GTTAATGCAT TTGCAAGAAA CTTTGATGAT AGAAGTGGAT 960

AGGCTCGATT TTTCTTTAGT GGAGCGGTTG AATGTTTTAG CGCGCATGGA GAATGAAAAG 1020

CATGCGTTT 1029

(2) INFORMATION FOR SEQ ID NO: 227:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1260 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1260

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:227:

ATGATTTTTG GGGATTTTAA ATATCAAAAA AGCGTTAAAA AACTCACAGC CACTAACCTT 60

AACGAGCTTA AAAACGCCCT GGATTTTATC TCTCAAAATA GGGGGAAGGG GTATTTTGTG 120

GGGTATCTTT TGTATGAAGC GCGCTTAGCG TTTTTAGATG AAAATTTTCA AAGCCAAACC 180

CCTTTTTTGT ATTTTGAACA ATTTTTAGAA AGAAAAAAAT ACCTTGTAGA GCATCTAAAA 240

GAGCATGCGT TTTACCCTAA AATCCACAGC TCTTTAGATC AAAAAACTTA TTTCAAGCAG 300

TTTAAGGCCG TTAAAGAGCA TCTCAAAAAC GGCGATACCT ATCAAGTGAA TTTGACAATG 360

GATTTATTGT TAAACACTAA GGCCAAACCA AAGCGCGTTT TTAAGGAAGT GATACACAAC 420

CAAAACACGC CTTTTAAGGC TTTTATAGAA AATGAGTTTG GGAGCGTTTT AAGCTTTTCG 480

CCGGAATTGT TTTTTGAATT AGAGTTTTTA GACACAGCGA TTAAGATTAT CACAAAACCC 540

ATGAAAGGCA CGATCGCTCG CTCAAACAAC CCCTTGATAG ATGAAAAAAA CCGATTGTTT 600

TTGCAAAATG ATGACAAAAA TAGAAGCGAA AATGTGATGA TCGTGGATTT ATTGCGTAAC 660

GATTTGAGCC GCTTGGCCTT AAAAAATAGC GTGAAAGTCA ATCAATTGTT TGAAATCATC 720

AGTTTGCCGA GCGTGTATCA AATGATAAGC GAGATTGAAG CTCAATTGCC CCTAAAAACA 780

AGCTTGTTTG AGATTTTTAA GGCGTTGTTC CCTTGCGGCT CTGTGACCGG ATGCCCTAAA 840

ATCAAAACCA TGCAAATCAT TGAAAGTTTA GAAAAACGCC CTAGGGGGGT GTATTGTGGG 900

GCGATAGGCA TGGTTGGAGG AAAAAAAGCC CTTTTTAGCG TGCCTATCCG CACTTTAGAA 960 AAAAGAGCGC ATGAAGATTT TTTGCATTTA GGGGTAGGGA GTGGGGTAAC TTATAAAAGT 1020

AAAGCTTCAA AGGAATATGA AGAGAGCTTT TTAAAATCCT TTTTTGTGAT GCCCAAAATA 1080

GAATTTGAGA TCGTGGAAAC GATGAGAGTT ATCAAAAGGG ATCAAAAATT AGAGATTAAC 1140

AATAAAAACG CCCATAAAGA ACGCTTAATG CATAGCGCCC AATATTTTAA CTTTAATACA 1200

GATGAAAATC TTTTAGACTT TGAATTAGAA GGAGAAGGGG TTTTAAGGGT TTTAATTCAA 1260

(2) INFORMATION FOR SEQ ID NO: 228:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 855 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...855

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 228:

AAACAAATAA GAAAAGAACG CTTGAACAAA CTGCTTAAAA AGGGGTTTTT AGCGTTCTTT 60

TTAAGCGTGT ATTTAAGGGC TGATGATCTG GTTACTTATA CGATCGCCAA AGAAGAAGAT 120

CTAGGGTACC AGCGGTTTTT AGCCAAGAAG TGTTTAAGGG GTAAAACCCA CCCCCCATGT 180

TTTACCGCGT CTAAAAAGCC CAAGAGGAAA CCTTTTAATA TAGATAAAAG CTCCCATTAT 240

TATGGCACGA GCGTGGTGCA AATGTCATGG CTACAGAGTA GGGAAAAATT TGAAAACCAT 300

TCAAAATACC GAAACATTCC TTTTGCTGAA GTCAGTTTGA TTTATGGCTA TAAACAATTT 360

TTTCCTAAAA AAGAGCACTA CGGCTTCCGT TTTTATGTCT CTTTGGATTA CGCTTATGGC 420

TTTTTTCTTA AAAATAAAGG CGCATTAGGC GATAGTTTGA GGGCGAGTTC GCAGATCCCT 480

AAAAGCTATA GAGAAAAATT ACAAAGAAAA GAGACTTTTA TTAACGCTAT TTTTTATGGC 540

GTGGGGGCTG ACTTTTTATA CAAACGCGCT TTTGGGACGC TGATTTTAGG GGTGAATTTC 600

GTGGGAGAAA CCTGGTTTTA TGAAACAAAG ATTTTCAAAC AATGGGCTAA AGACTCTCTA 660

AATACTTACC GCCCCAACAT GTTTCAAGTG ATGTTGAATG TGGGGTATCG CTACCGCTTT 720

TCAAGGTATA AGAATTGGGC GATAGAATTT GGCGCGCGCA TCCCCTTTTT AATTAATGAT 780

TATTTTAAAA CCCCTTTATA CACCCTTCAT TTCAAACGCA ATATTTCTGT CTATCTCACT 840

TCAACTTATG ATTTT 855

(2) INFORMATION FOR SEQ ID NO: 229:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 693 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...693

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:229:

AATACTCTTT TTTATTTCTT TTTATTACAG GCGGTTATTG TGTTAGATAG TTTTGAGATT 60

TTAAAGGCTT TAAAGAGCTT GGATTTATTG AAAAACGCCC CTGCTTGGTG GTGGCCTAAC 120

GCTTTGAAAT TTGAAGCTCT ACTAGGAGCG GTTTTAACGC AAAATACTAA ATTTGAAGCC 180

GTTTTGAAAT CTTTAGAAAA TCTAAAAAAC GCTTTCATTT TAGAAAATGA TGATGAGATC 240

AATCTTAAAA AAATCGCTTA TATAGAGTTT TCAAAGCTTG CAGAGTGTGT CCGCCCTAGC 300

GGGTTTTATA ACCAAAAAGC CAAACGACTG ATTGATTTGA GCAAGAATAT TTTAAAAGAC 360

TTTCAAAGTT TTGAAAATTT TAAACAAGAA GTAACCAAAG AGTGGCTTTT AGACCAAAAG 420

GGCATTGGCA AAGAAAGCGC GGATGCGATT TTATGCTATG TGTGCGCCAA AGAAGTGATG 480

GTGGTGGATA AATACAGCTA TCTTTTTTTA AAAAAATTAG GCATAGAGAT AGAAGATTAT 540

GATGAATTGC AGCATTTTTT TGAAAAAGGC GTTCAAGAGA ATTTAAATTC CGCCTTAGCG 600

CTTTATGAAA ACACCATTTC TTTAGCGCAA CTTTATGCGA GATTCCATGG AAAGATCGTG 660

GAATTTTCCA AACAAAAATT GGAATTGAAG CTT 693

(2) INFORMATION FOR SEQ ID NO: 230:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 693 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...693

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 230:

ATCAGCTTCA ATGCGGACTA CTTTAGGATT TGGGCGCGCG ATTTTGCCAC CGGGCAGTAT 60

TCAGTCTATA CGAGCGGGCC CATGAAAGGT AATGTGCGCC CCATTAATGG CTATTCTCAA 120

GGCGTGGAGC TGGAATTGTA TTACAGGCCC ATTAGAGGGT TGCAATTCCA TGCCGCTTTC 180

AACTACATTG ACACTCGTGT AACTAGCCAT GGCCCTTTAA CCGACTTGAA CGGGGATGTG 240

CTAAAAGGGA CTAGCTATAA CAAGCATTTC CCTTTTGTAA GCCCTTTCCA ATTCATTTTT 300

GACGCTCGCT ACAATTGGCG TAAAACCACC ATTGGTATTT CTAGCTATTT TTATAGCCGT 360

GCTTATAGCG GGATTAGCAA CAGCGCAGCA GGAGGCTATT ATGGGATGCA ATACTATAGT 420

GGGGGGAACA ACTATGAAAG CGTTCTTAAT AGCGGTTATC AATGCGAAGC TTGGTGTATG 480

ACCCAACATG AAGGGCTCTT GCCTTGGTAT TGGGTGTGGA ATATCCAAGT GAGCCAAATT 540

TTCTGGGAAA ACGGAAGACA CAGAGTTACA GGAAGCTTAC AAATCAATAA CATCTTCAAC 600 ATGAAGTATT ATTTTACAGG GATTGGCTCT AGCCCTGCAG GCTTGCAACC TGCGCCTGGA 660 AGATCGGTTA CAGCGTATTT GAACTACACT TTC 693

(2) INFORMATION FOR SEQ ID NO: 231:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 804 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...804

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 231:

AGCGGTGTTG TGAAAATGAA AGACAAAAAG ATTGATGAAG AAACGAACGC CGTTTTAGAG 60

GGGGAAAAAT ACACCGTGTG CGTGTCTTGT CAAATCGGCT GTCAAGTGGG TTGCTCGTTT 120

TGTTTCACTC AAAAAGGCGG TTTTGTAAGG GATCTCAAAG CGAGCGAGAT TATCCAGCAA 180

GCCCTACTCA TTAAAGAGGC CAATAACCTC CCCATTGAAA AAGCGCTCAA CATTGTTTTT 240

ATGGGAATGG GCGAGCCTTT GAACAATTTA GATGAGGTGT GTAAAGCGGT TGAGATTTTT 300

AATACCGGCA TGCAAATTTC ACCTAAAAGA GTCACCATTT CCACGAGCGG CGTGGCCGAT 360

AAAATCCCCA TTTTAGCGGG CAAAAACTTA GGCGTGCAAT TAGCCATATC CTTACACGCC 420

GTAGATGATA AAACGCGCTC GTCTTTAATG CCCTTGAATA AAAAATACAA CATTGAATGC 480

GTTTTGAATG AAGTGAGGAA ATGGCCTTTA GAGCAGCGAA AAAGAGTGAT GTTTGAATAC 540

CTTTTAATCA AAGATTTAAA CGATAGCCTG GATTGCGCTA AAAAACTTTT AAAACTTTTA 600

AACGGCATTA AATCCAAAGT GAATTTGATC TTATTCAACC CGCATGAAGG CTCTAAGTTT 660

GAGCGCCCTA GCTTAGAGAG CGCCAGAATG TTTGCGAATT TTTTAAACGC CAAAGGCTTA 720

TTATGCACCA TTAGAGAATC CAAAGCCTTG GATATTGAAG CGGCTTGCGG GCAATTGAGG 780

GAGAAAAAGC TCCAGCAGAA AATT 804

(2) INFORMATION FOR SEQ ID NO: 232:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 708 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori (ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...708

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:232:

AGATTGTCTG AACCCATAGA TAGATTCACA CGCATAAGGT GGTTGTTTAA AAACGATTTT 60

GAAAAAATCC GCCAACAAAG GGTTTTAATC TGTGGCGTGG GGGGCGTTGG AGGCTTTGCA 120

CTAGATTCTT TGTATCGTGT GGGGATAGGG CAAATCACTA TCATTGATAA AGACATGTTT 180

GATGTTACCA ATCAAAACCG CCAGATTGGA TCAGAAAGGA TAGGAGAATC TAAAGTGTTG 240

GTGTTGCAAG ATCTCTATAA AGGCATCCAA GCTTTAAATT GTCGCATAGA TGAAGCGTTT 300

TTAAATTCAT TTAATTTTAG AGATTATGAT TACATTTTAG ATTGCATGGA CGATTTGCCT 360

ATTAAAACAA GCCTAGCGAT AAAATGTCAA AATTTCGCTT ACGGGAAGTT TATCAGCTCT 420

ATGGGGAGCG CGAAGCGTTT GAATCCTAAA CACATCCAAG TGGGGAGCGT GTGGGAAAGC 480

TATGGCGATA AATTCGGGCG TAAATTTAGG GATTTTTTAA AAAAACGCCG TTTTAAGGGG 540

GATTTTAAGG TGGTTTTTAG CCCTGAAGTC CCGCATTGCA TAGAGCTTGG AAGCTTTAAT 600

GCGGTTACGG CGAGTTTTGG TTTGCAAATA GCGAGTGAAG TCGTGCAAGA TATTATCAAA 660

AATGAAAGGC AATGGAATGA AAGATTACGA AGACGAATTG GAAGATTT 708

(2) INFORMATION FOR SEQ ID NO: 233:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 999 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...999

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 233:

GCGAAAGCTA GGGTGCAATT CAACCGCGCG AATGAACGCC AACGCAGGGC TAAAGAATTT 60

TATTATGAGG AAGTGCAAAA AGCCATTAAA GAAATCGATT CTAGCAAAAA GCACAATATT 120

AATATGGAAC GCTCTAGGGC AGAAGTGAGC GAGATTTTAA ACAACACCTA TTCTAATTTA 180

GACAAATACG AAGCTTATCA AGGCTTGCTT AACCCGGCGG TTTCGTATCT TTCAGGGTTG 240

TTTTACGCTT TAAATGGGGA TAAGAATAAG GGATTAGGCT ATCTTAATGA AGCCTATGGG 300

ATCAGTCAAA GCCCTTTCGT GGCTCAAGAC TTGGTTTTTT TCAAAAACCC TAACAGGAGC 360

CATTTCACTT GGATCATCAT TGAAGATGGT AAAGAGCCGC AAAAAAGCGA ATTTAAAATT 420

GATGTGCCTA TTTTTATGAT TGATTCGGTT TATAACGTGA GCGTGGCCTT GCCCAAGCTA 480

GAAAAAGGGG AAGCGTTTTA TCAAAATTTC ACCCTCAAGG ACGGAGAAAA AGTAACACCC 540

TTTGACACTT TAGCCTCAAT AGATGCGGTG GTCGCTAGCG AATTCAGGAA GCAATTGCCC 600

TACATTATCA CTAGGGCTAT TTTATCGGCC ACTTTTAAAG TGGGCATGCA AGCGGTGGCG 660

AACTATTATT TAGGGTTTGT TGGCGGGTTA GTAACTTCGT TGTATTCAGG TGTGAGCACC 720

TTTGCAGACA CCAGAAACAC GAGCATTTTT GCCCATAAAA TCTACCTCAT GCGCATCAAA 780

AACAAAGCCT TTGAAAGTTA TGAAGTTCGA GCCGATTCCA TTGACGCTTT TTCGTTTTCA 840 TTAAAGCCTT GTAAAAGATC GCTTGAAAGC CCTAAAATCA TTGACGCTAG GGAATTGCTT 900 TCAGGGTTTG TAACAGCCCC ACAAGTCTTT TGCTCTAACC GCCATAATAT TTTATATGTG 960 CGCAGCTTTA AAAACGGGTT TGTTTTGAGT CATTTAAAA 999

(2) INFORMATION FOR SEQ ID NO: 234:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 273 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...273

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 234:

AGGAATAAAG ATAAAAGAGA GTATTTTGAA AACGCCACCG CGCAAATTGG GGCTAAACTC 60

TTGGTGTGCG ATATTAGAGA GCAGTTCTTT AACGATGTGT TGTTCAAGCC CAAATACGGC 120

TATGGGAAGT ATTTCAACCC TTGCATTGAT TGCCATGCCA ACATGTTTAG GAACGCTTTT 180

TATAAAATGC TTGAATTGGA TGCGGATTTT GTTTTGAGCG GGGAAGTGCT AGGCAACGCC 240

CTAAATCCCA AAGGAAAGAA GCGCTCAATC AGG 273

(2) INFORMATION FOR SEQ ID NO: 235:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 906 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(id) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...906

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 235: GGGGAAGTCA TGGCTGATAG TTTAGCGGGC ATTGATCAAG TTACGAGTTT ACATAAAAAT 60 AACGAGTTGC AATTGTTGTG TTTCAGGCTG GGTAAAAACA AGGATTTGTA TGCGGTCAAT 120

GTCTTTAAGA TCCGTGAAGT GGTGAAATAC CATGGCAATC TCACTATCAT TAGCCACGAA 180

AACAATTCGC TCGTTGAGGG CTTGATCATT ATAAGAGAGC TCACCATTCC TTTGATTGAC 240

ATGAAAAAAT GGTTTTATTA TGACAGCCAA AACAAGAGCA AGGATTTACG CCCTTACAGG 300

ATACAAAAAG AAAAAAGCGA AGACGATATT GTCATGATTT GTGAGTTTTC TCGCTGGACC 360

ATAGGGGTTA GGATTTATGA AGCGGATAGG ATTTCGAGCA AGAAATGGAC TGAGATGGAG 420

CAAAGCGCTG GGCTACGGGG ATCTGCTGGG AATAACAAAC TCGTGAGCCG CACGCGCTAT 480

TTTGACGGGC GCTTGGTGCA AGTGGTGGAT ATTGAAAAAA TGCTTATAGA CGTGTTCCCT 540

TGGATTGAAG ATGAAAAACA CAACGATGTA GAGACGCTTT CTAAAATCCA TTCTAACCAA 600

TGCGTTTTGC TCGCTGATGA TTCCCCAAGC GTCTTAAAAA CCATGCAAAT GATTTTAGAC 660

AAGCTGGGCG TCAAGCACAT TGACTTTATC AATGGTAAAA CCTTATTAGA GCATTTGTTC 720

AACCCAACAA CCGATGTGAG TAATATTGAC CTGATTATTA CCGATTTAGA AATGCCAGAA 780

GCGAGCGGTT TTGAAGTGAT CAACCAGGTT AAAAACACTC CTTTGACTTC AACAATCCCC 840

ATTGTGGTCA ATTCTTCTAT GAGCGGGAGC TCTTATGAAA AAAATGGCAA GAATTTGAAT 900

GGCCAA 906

(2) INFORMATION FOR SEQ ID NO: 236:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 378 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...378

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 236:

GCAGTAGCGT TTTGCTTACC GTATTCAAGC CCAAAGACTT CTTTAGCCAC TGAATTGCAC 60

TATAGCGCTA ATGAACGCAT AGAGGCTTTT TCAAGCAATG ACGAAAAAAC AGAGAGTTTT 120

GAACTGAATG AGCAAAGTTT TGAGGCGATT AAAGAGAATG CGGCGAAGTA TTCATACCTT 180

AAGGTTTATT TGAAGAACGT AGCCTTAAAA GATAGTGCGC CTTTAGTGTT TGTGGATATG 240

CCCGGGTTTG ATAGCCCCAT TTCAAGCCAC ACCCATGCCA TTTTGGAATA TTTGGAAAGG 300

GGCGTGCATT TTGTCATTCT CACAAGCGTA GAAGAGGGTA ACCTCACTAA ACGCATGGTT 360

AGGGAGTTAA AAACCTTT 378

(2) INFORMATION FOR SEQ ID NO: 237:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 975 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (ill) HYPOTHETICAL- NO

(iv) ANTI-SENSE- NO

(vi) ORIGINAL SOURCE.

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE.

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...975

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:237:

CGGCACCCGA TTGAAAATTC GATCTGCGAT CTTAGCGAGT TGAATAATTT AAAGCCTTTG 60

GGCGCGGAAA TGTTTGTGGG GTTAGACGGC ATTGATGCGA TGATAGAGGA GTGCGTTTCC 120

AATTTAGTCA TTAACGCCAT TGTGGGCGTA CCCGGATTGA AAGCGAGCTT TAAAAGCTTA 180

CAAAGGAACA AAAAACTAGC CCTAGCGAAT AAAGAAAGTT TAGTGAGCGC GGGGCATTTA 240

TTAGACATTT CACAAATCAC GCCCGTTGAT AGCGAGCATT TTGGTTTGTG GGCGTTGTTG 300

CAAAACAAGA CTTTAAAGCC TAAATCTTTA ATCATTAGCG CGAGTGGGGG GGCTTTTAGG 360

GACACGCCCT TAGATCTTAT CGCTATTCAA AATGCGCAAA ACGCGCTCAA GCACCCTAAT 420

TGGAGCATGG GGGATAAAAT CACCATTGAT TCAGCGAGCA TGGTCAATAA ACTTTTTGAA 480

ATTTTAGAAA CCTATTGGCT TTTTGGTGCG TCTTTAAAGA TTGACGCGCT GATTGAAAGA 540

AATTCTATCG TGCATGCTTT GGTGGAGTTT GAAGACAACT CTGTCATTGC GCATTTAGCG 600

AGTGCGGACA TGCAATTACC CATAAGCTAT GCCATTAACC CTAAATTAGC TTCTTTGAGT 660

GCTTCCATTA AACCCTTAGA TTTATACGCT TTAAGCGCGA TTAAATTCGA ACCCATTAGC 720

GTGGAGCGCT ACACTTTGTG GCGTTATAAA GATTTGTTGT TGGAAAACCC AAAGCTTGGC 780

GTGGTGCTGA ATGCGAGCAA TGAAGTGGCG ATGAAGAAGT TCTTGAATCA AGAAATCGCT 840

TTTGGTGGCT TTATCCAAAT CATCTCTCAA GCTTTAGAAT TGTATGCTAA AAAATCTTTC 900

AAGCTCTCTA GTTTAGATGA AGTGCTAGCG TTAGATAAGG AAGTTAGGGA GCGTTTTGGA 960

AGTGTAGCGA GAGTG 975

(2) INFORMATION FOR SEQ ID NO: 238:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 396 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(11.1) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...396

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:238:

GAGACGCTCG CAAGGGTTCT CAAAGTTTCA TGTTTGGCTA TGGGGCTGGC ACAGATGTGT 60 TGTTTAACCC AGCTATTTTC AATCGTGAGA AACTTGCATT TGGGGTTTTT CTTGGGCGTT 120 GCGATTGGTG GCACCTCTTG GGGTCCAACA AACTATTATT TTAAGGACTT AGCTGAAGAG 180 TATAGAGGGA GTTTCCACCC ATCAAATTTC CAGGTCTTAG TTAATGGCGG GATCCGCTTA 240

GGCACTAAAC ACCAAGGTTT TGAAATTGGC TTGAAAATCC AAACCATTCG CAATAATTAC 300

TATACCGCTA GCGCGGATAA TGTGCCTGAA GGGACTACTT ATAGATTCAC TTTCCACCGC 360

CCTTACGCCT TTTATTGGCG TTACATTGTA AGCTTT 396

(2) INFORMATION FOR SEQ ID NO: 239:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 180 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY, circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...180

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 239:

GTCTTAAAGA ATGAAATAAG CTATAATAAG CCCATTTTGA ACACCAACGA TTATTTGAAT 60 AAAGACAATA CGATGAAAGA TAGTTTTCTT TTCACTTCCG AATCAGTAAC CGAAGGGCAT 120 CCTGATAAAA TGGCCGATCA GATCAGCGAT GCGGTTTTAG ATTACATGAT TGAGCGGGAT 180

(2) INFORMATION FOR SEQ ID NO: 240:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 333 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...333

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 240:

AAAACCAAAG TCGCATGCAA GACTTTAGTT TCTAATGGTT TATGCATGAT CACTGGCGAG 60 TTAGAAACTT CTGTTTATGC ACCGATGCTA GAGATCGCAA GACATATGGT TAGAAAAATT 120 GGCTATACAA ACGCTCTCTA TTGCTTTGAT TACAGAAGCG CGGCGGTTTT AAATGGCATT 180

GGCGAGCAAA GTCCTGATAT TAATCAAGGC GTGGATAGAG AAGATGGCGA GATTGGGGCG 240

GGGGATCAAG GGCTTATGTT TGGTTATGCA TGCAAAGAGA CTGAAACGCT CATGCCTTTA 300

CCCATCCATT TAGCGCACCA GCTCGCTTTC GCC 333

(2) INFORMATION FOR SEQ ID NO: 241:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 507 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...507

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:241:

TCCTTATCAA CACTTGCGGT TTTATTGAAA GCGCTAAACA AGAGAGTATT CCAAACCATT 60

CTCAACGCAG CCAAAGACAA AAAAGAGGGA GCGATTTTAA TTGCGAGCGG GTGCTTGAGC 120

GAGCGCTATA AAGATGAAAT CAAAGAATTG ATCCCTGAAG TGGATATTTT TACCGGCGTG 180

GGGGATTATG ACAAGATTGA TATTTTAATC GCTAAAAAAC AAAACCAATT CAGCGAGCAG 240

GTGTTTTTAA GCGAGCATTA TAACGCGCGC ATTATCACGG GATCGAGCGT GCATGCTTAC 300

GTTAAAATTT CTGAGGGCTG TAACCAAAAA TGCTCTTTTT GCGCTATCCC TAGCTTTAAG 360

GGAAAATTAC AAAGCAGGGA ATTAGACTCC ATTTTAAAAG AAGTAGAAGA TCTAGCCCTT 420

AAAGGCTATA AAGATATGAC TTTTATCGCT CAAGATTCTA GCTCATTTTT ATCCGATAGG 480

GCAAAAAGTC GGCTTGATCC AGCTCAT 507

(2) INFORMATION FOR SEQ ID NO: 242:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 474 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature (B) LOCATION 1...474

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 242:

AATTTAAGGA CTATAATGCA TTATTCTTAT GAAGCCTTTT TAAAAGACAG CCTGGAGTTA 60

GCTAAACAAG TGGAGCGCCT TTGCGGTATC CCAGAAGCCC TTGTGTGCGT GATGCGAGGG 120

GGCATGACTT TAGTGCATTT TTTGAGTTTG CACTGGAATT TAAGGGAAGT TTATGGCATC 180

AATGCGATTT CTTATGACAC CACCAAGCGA CAAAACGCCC TAAAAATTGA AAATACCCCC 240

ACGATCAAAG ATCATTTAAA AACCATTTTA GTGGTAGATG AAATCGTAGA TAGCGGTAAT 300

TCTTTGGAAG CGGTACTTAA AGTGTTGCAA GACAAACACC CTGATAAAAA GTTTTATAGC 360

GCGAGTTTGT TCCAAAAAAC AAGCGCGAAA TACAAAGCCG ATGCGTTTTT AAAAGACGCT 420

CCTGAATGGA TTGATTTCTT TTGGGAAGTG GATTTGAAAA ACTTGAAAAG CCAC 474

(2) INFORMATION FOR SEQ ID NO: 243:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 681 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...681

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 243:

TCCAGCTCAT TAGAGCGATT GCCAGCAAGC CTTAAAGACG CGCGTATTTT ATACCTCTAC 60

CCCTCTAGCA CCACTTTAGA GCTGATTGGC GCGATTGAAG ACTCGCCTAT TTTTCAAAAT 120

TATTTTTACA TGCCCATTCA GCATATCAGC GACTCCATGC TTAAAAAAAT GCGGCGCAAC 180

TCCAGCCAAG CACACCATTT AAAGCTTTTA AACGCCATGA AGCAGGTTAA AGAAAGCTTT 240

ATAAGAAGCA CGATCATTGT AGGGCATCCA GAAGAAAATG AGAGCGAATT TGAAGAATTG 300

AGCGCGTTTT TAGACGAGTT CCGGTTTGAC AGATTGAATA TTTTTGCTTT CAGTGCTGAA 360

GAAAACACGC ATGCCTATTC TTTAGAGAAA GTGCCTAAAA AAATCATCAA CGCCCGCATT 420

AAAGCCTTGA ATAAAATCGC TTTAAAACAC CAAAACCATT CTTTTAAGGC TTTGTTGAAT 480

AAGCCCATTA AGGCGTTAGT GGAACATAAA GAGGGCGAAT ATTTTTACAA AGCAAGGGAT 540

TTGAGATGGG CGCCTGAAGT GGATGGGGAA ATTTTAATCA ATGACAGCGA ACTAACCACC 600

CCTTTAAAAC CCGGGCATTA CACGATTGTG CCTAGCGCCT TTAAAGACAA TATTTTACTC 660

GCTAAGGTTT TAAGTCCTTT T 681

(2) INFORMATION FOR SEQ ID NO: 244:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 324 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular (11) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...324

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 244:

ATAACGAATA CAACTTTCCA ACTCCAAGGC GTTTTATTGG AATACGATTT TGAACGGCCT 60

GCTATCTCTT ATACCCCTAA AAAAAGCGTT TTTAATGAGC GCTTGAAGGA TTTGAGGGAA 120

AATTTTAGCG CTTCTTTATA CGCTGATTTG AAAGACAAGA TCCATCATAA CGCCTTGTCT 180

AACGATGATT TAGAACGCAT GATAGCTTTT AGAGAGCAAG AATTTGAAAA GAGTTTAGAG 240

GATTGGATGG GTGCATATTC TTATGATGCA ACCCTGAGGT GTTTTAGTAG CGAGCGTATC 300

TATCTAGACC GGTTGGGGTG GGAA 324

(2) INFORMATION FOR SEQ ID NO: 245:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1092 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1092

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:245:

AAAAAGGTGG TTATGAATGG TTTTTGCGCT AGACTACGAG CCATAACATT TAATGAAAGA 60

CTAAAAATGA AAATAGCGGT ATTACTCAGT GGGGGGGTGG ATAGCTCTTA TAGCGCTTAT 120

AGCTTAAAAG AGCAAGGGCA TGAATTAGTG GGGATTTATT TAAAACTCCA TGCGAGTGAA 180

AAAAAGCATG ATTTATACAT TAAAAACGCT CAAAAAGCGT GCGAGTTTTT AGGCATTCCT 240

TTAGAGGTGT TGGATTTTCA AAAGGATTTT AAAAGCGCGG TTTATGATGA ATTTATCAAC 300

GCCTATGAAG AAGGGCAAAC CCCTAACCCA TGCGCGTTGT GCAACCCTTT AATGAAGTTT 360

GGGCTAGCTT TAGATCACGC TTTAAAATTA GGGTGTGAAA AGATCGCTAC CGGGCATTAT 420

GCGAGGGTCA AAGAAATTGA CAAGGTAAGT TATATTCAAG AGGCTTTGGA TAAAACTAAA 480

GATCAGAGCT ATTTTTTATA CGCTTTAGAG CATGAAGTTA TCGCTAAATT GGTGTTCCCT 540

TTAGGGGATT TGCTAAAAAA GGATATTAAG CCTTTAGCCT TGAATGCGAT GCCCTTTTTA 600

GGCACTTTAG AAACTTATAA GGAATCTCAA GAAATCTGCT TTGTGGAAAA AAGCTACATT 660

GACACTTTAA AAAAGCATGT TGAAGTGGAA AAAGAGGGCG TGGTGAAAAA CCTACAAGGC 720 GAAGTCATTG GCACGCATAA AGGCTATATG CAATACACGA TTGGCAAACG CAAAGGCTTT 780

AGTGTTAAAG GCGCGTTAGA GCCGCATTTT GTGGTGGGGA TTGACGCTAA AAAGAACGAG 840

TTGATTGTGG GCAAAAAAGA AGATCTCGCC ACGCATTCGC TTAAGGCTAA AAACAAATCT 900

TTAACGAAAG ATTTTAAAGA TGGCGAATAC TTCATCAAGG CCCGTTACAG GAGCGTGCCT 960

ACTAAAGCGT TTGTGAGCTT AAAAGATGGA ATGATTGAAG TGGAATTTAA AGAGCCTTTT 1020

TACGGCGTGG CTAAAGGGCA AGCCTTGGTC GTTTATAAAG ATGATATTTT GCTTGGCGGG 1080

GGCGTGATTG TT 1092

(2) INFORMATION FOR SEQ ID NO: 246:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 399 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...399

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:246:

TTGTTTAAAA CCAATGGGAT AAGTGTGGGG GAATACACTC ATTTTAGCGA AGATATAGGC 60

AGTCAATCGC GTATCAATAC CGTGCGTTTG GAAACTGGCA CTAGGTCAAT CTTTTCTGGG 120

GGTGTCAAAT TTAAAAGCGG TGAAAAACTA GTTATCAATG ATTTTTACTA TAGCCCTTGG 180

AATTATTTTG ACGCTAGGAA TGTTAAAAAT GTTGAAATCA CCAGAAAATT CGCTTCTTCA 240

ACCCCAGAAA ACCCTTGGGG CACATCAAAG CTCATGTTTA ATAATCTAAC CTTGGGTCAA 300

AATGCGGTCA TGGACTATAG TCAATTTTCA AATTTAACCA TTCAGGGGAT TTTATCTACA 360

ATCAAGCGAT ATCATTTGAC GAAGGGTTTT TTTACCCCC 399

(2) INFORMATION FOR SEQ ID NO: 247:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 246 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

( i) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi ) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE: (A) NAME/KEY: misc_feature (3) LOCATION 1...246

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:247:

ATGAAAAAAA CCCGTATCCG GAAGAAGTCA GCTTTAATGA ATGGCTGTTG GGCGGAATTT 60

GATAGCGTTT TTAGCGCCAT TGTGCCTTTA GAAGATTTAA ATAAAACCGC ATGCGCTCAT 120

CATGCCCTAA AGGCTTTACA AGCTACGCTA AAGACAACGA TTTGGGCTTT GATGCGACAG 180

AGTTGGAACA GATCGCAAAA GGATTCATCC CTAGGGGGTA TTTGTGGCAT TTTGACGCGA 240

ATGTTT 246

(2) INFORMATION FOR SEQ ID NO: 248:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 315 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...315

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 248:

TGGACTCTAG CCAAAATTCG TTGCGTTAAA AACTTTAAGG AAGCTATAGA AGGTTTTACA 60

GAAAAAATCA AAGAATCCCC TAACGATTCA AACGCTATCA ATGAAGCCTT TGATAATTTA 120

GAAACAGAGT TAGAGCGCGC TACAGAAAAT TTGAGTCAAA AAATCGATCC CGTTTTAGAA 180

CGGAATGAAA ATTATACGCA AAAAGCGTTG GAGTATAGGG AGTTTTTAGA AAGCCGTAAA 240

GAGAGCTTTA TTGTAGATGA AAAAAACCCG TATCCGGAAG AAGTCAGCTT TAATGAATGG 300

CTGTTGGGCG GAATT 315

(2) INFORMATION FOR SEQ ID NO: 249:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 852 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori ( ix ) FEATURE :

(A) NAME/KEY: misc_feature

(B) LOCATION 1...852

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 249:

AGACCTTTGG CACTCATCAT GTGGTGGCGA AATATAGACA ATCGTATCTC TATTAAGCGC 60

GTTGTAAACA AGCCCCCAAG AGGCCTTGGC AAGATCACTC AAGAATGGAT TTTTTCTCTT 120

TTAGATGAAG AGGGTTTGAA TTTAGAAGAA GCGCTAAAAA TTGGGGCGTT TAAAGACAAA 180

CTCAACCCTA AAAACGAATA CGCTTTAAAG AAATTCACCG CTATGATAGG GCGTTTGAGG 240

GAGGCTTTTG AAATTTCAGT AGAGAAGTTT TGCGAGCGGT TTTTAGAAGA GACTAACCTT 300

TTAAAAAGCT ATGAAAAAGA AGACAATTAC GAAGAAAGAG AGGGCTTTGT TAAAGAGCTT 360

TTAAGTTTAG TGAAAGAGCA TTTTAAAACT AACCCCACGC ATTCTTTACT GGATTTTTTG 420

AATGAAAGCG CACTGGATGT CCATAATACA GAAAACGCGC AAAAAGTGAG TTGCATGAGC 480

GTGCATATGA GTAAGGGCTT AGAGTTTAAG CATGTGTTTG TGATCGGGTT AGAAGAGGGG 540

TTTTTCCCGC ATAGGGGGTT CAATCAAGAA AGCGATTTGG AAGAAGAAAG GCGCTTGGCT 600

TACGTGGCGA TCACTAGGGC TAAAGAAGAA TTACAACTTT CTTATGTCAA AGAGCGTTCG 660

TATTTTGGGA GGAAAATTTC TTGCTCGCCC TCTGTGTTTT TAGAAGAAGC CCAGTTGCTC 720

CAACAAGACA AGCCTCCTAA ACAAAATCAC CAAAAAGATA CGCCCATTAA AGTGGGGGAT 780

TTGATCAAAC ATAAGATTTT TGGCACCGGG GAGGGTTTTA GGCGTAGAAA AAGGCTTGCA 840

GCGGTTTGTG CT 852

(2) INFORMATION FOR SEQ ID NO: 250:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 726 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...726

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:250:

GATGGGTCAA AAAAGATGAA GTCAAATAAA AAGTCCAATC ATTTAAGAGC GATTTATAGG 60

GCTTTAGTGA TCGCTATAGG CTTAGCCGTT ATCATTGTTT TCAATTATTT TAACCGCAAA 120

AACAATAACG CCCGCTCCAG CCGTAGGGCT TGTTCGTGTT TTTTTCCCCC CACCGGGGTT 180

AATTTAGAAA AAATAGGTTC CTTTGACACG GGCGCTAAAC TCATTGTCTT AAACCACCAA 240

AGCTTACTAG ACATTATTTA TTTAGAAGCC TACCACCCTA GTAATATTTG CTGGATCGCT 300

AAAAAAGAGC TGGGCGAAAT CCCTTTTTAT GGGCATGCTC TAACGGATAC CGGAATGATC 360

TTAATTGACA GAGAGGATAA AAAGGGGATA GTGAGCCTTT TGAAAGCATG TAAAGAAAAG 420

CTAGATCAAA ACCGCCCTTT AGTGATTTTT CCTGAAGGCA CTAGAGGCAA AGGAGGAGAA 480

AAATTCCTCC CCTTTAAGCA AGGGGCTAAA ATCATCGCTG AAAAATTCCA GCTCAAAATC 540

CAGCCCATGG TGTTAATCAA TTCCATTAAA ATCTTTAATT CCAAGCCCCT AGAAGCTTAT 600

AAAGCGCGCA CCCGTTTGGT CATGCTAGAA AGCTATACGC CTGATTTTAG CTCGCCCACC 660 TGGTATGAAG AATTACAAGA ACGCATGCAA AAAGAATATT TAAAACACTA CCACGAACTA 720 AACGCA 726

(2) INFORMATION FOR SEQ ID NO: 251:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 831 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...831

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 251:

GTCATGAAAA CTTCTAACAC AAAAACCCCT AAACCCGTTT TAATCGCCGG GCCATGCGTC 60

ATTGAGAGTT TAGAAAATCT AAGAAGTATC GCTATTAAAT TACAACCCCT AGCCAACAAC 120

GAGCGGTTGG ATTTTTATTT TAAAGCGAAT TTTGATAATG CTAACCGCAC GAGTTTGGAA 180

AGTTACAAAG AACCTGGTTT AGAAAAAGGC TTAGAAATGT TACAAACTAT CAAAGATGAA 240

TTTGGTTATA AAATTTTAAC CGATGTGCAT GAGAGCTATC AAGCAAGCGT GGCAGCCAAG 300

GTAGCGGATA TTTTACAAAT CCCGGCGTTT TTGTGCCGCC AAACGGATCT GATTGTAGAA 360

GTGAGCCAAA CTAACGCCAT TGTCAATATC AAAAAAGGGC AATTCATGAA CCCAAAAGAC 420

ATGCAATATT CCGTTCTAAA AGCCCTTAAA ACAAGGGATA GTAGCATTCA AAGCCCCACT 480

TATGAAACAG CGTTAAAAAA TGGCGTGTGG CTGTGTGAAA GGGGGAGCAG CTTTGGGTAT 540

GGGAATTTAG TGGTGGATAT GCGCTCTTTA AAAATCATGC GAGAATTTGC CCCTGTGATT 600

TTTGACGCTA CCCATAGCGT GCAAATGCCA GGGGGAGCGA ACGGGAAAAG TTCAGGAGAC 660

AGCTCTTTTC CCCCTATTTT ACCCAGAGCG GCGGCGGCGG TGGGGATTGA TGGGCTGTTC 720

GCTGAAACGC ATATTGATCC TAAAAACGCC CTAAGCGATG GAGCAAACAT GCTAAAACCT 780

GACGAGCTAG AACACTTAGT AACCAACATG TTAAAAATCC AAAATTTATT T 831

(2) INFORMATION FOR SEQ ID NO: 252:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 939 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori (ix) FEATURE:

(A) NAME/KEY: misc_feature (3) LOCATION 1...939

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 252:

CAAAGAGATC ATGGCGTTTT GTATTTGCTT AATAACACTA TAATAAAATT TTTAATAAGG 60

AGATACATCA TGTTAGAAAA TGTCAAAAAA TCCCTTTTTA GGGTTTTGTG CTTGGGCGCG 120

TTGTGTTTAG GGGGGCTAAT AGCAGAGCAA GACCCTAAAG AGCTTGTCAA TTTGGGAACA 180

AAGAGCTACA AAGAGCAGGA TTTCACTCAG GCTAAGAAAT ATTTTGAAAA AGCTTGCGAT 240

TTGAAAGAAA ATAGCGGGTG TTTTAATTTA GGGGTGCTTT ATTATCAAGG GCATGGGGTG 300

GAAAAGAATT TGAAAAAAGC CGCTTCATTT TACTCTAAAG CTTGCGATTT AAATTACAGC 360

AATGGGTGTC ATTTGCTAGG GAATTTATAT TAT GCGGGC AAGGCGTGTC CCAAAACACC 420

AACAAAGCCT GGCAATACTA CTCTAAAGCG TGCGATTTGA AATACGCTGA AGGGTGTGCG 480

AGCTTAGGGG GGATCTATCA TGATGGCAAA GTGTTTACTA GGGATTTTAA AAAAGCGGTG 540

GAATATTTCA CTAAAGCTTG CGATTTGAAC GATGGCGATG GTTGCACGAT ATTAGGGAGC 600

TTGTATGATG CAGGCAGAGG CACGCCTAAA GATTTGAAAA AAGCGCTCGC TTCGTATGAT 660

AAAGCTTGCG ACTTAAAAGA CAGCCCAGGG TGCTTTAACG CAGGGAACAT GTATCATCAT 720

GGCGAAGGTG CGGCGAAGAA TTTTAAAGAG GCCCTCGCTC GTTATTCTAA GGCATGCGAG 780

TTGGAAAATG GCGGAGGGTG TTTCAATTTA GGGGCTATGC AATACAATGG CGAAGGCGCA 840

ACAAGGAATG AAAAGCAAGC CATAGAAAAC TTTAAAAAAG GCTGTAAATT AGGCGCTAAA 900

GGGGCATGCG ATATTCTCAA GCAGCTCAAA ATCAAAGTT 939

(2) INFORMATION FOR SEQ ID NO: 253:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1590 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1590

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:253:

ATGAGCAGCG GGTTAATTTA CATTTCATTA GAAGTCTTGG TAGCGTGTTT GATCACCGCT 60

CTAATCATGT ATTATGTGAT GAAAAAGATC TATTACGCTA GAGGGCAAGC CATTTTAAAA 120

GGCGCTTCAG CCAAAGCTAA ATTAATGGAA TTTCAAGCGA AATCTTTCGT GGAAGCTGAA 180

GAAATGCGCA TGAAAAGCCA AGAATGCAAG TTGCAACAGC AATATGAAAA TAAGAATTTG 240

CAACTCCAAA CCCATTTTGA TAAAAAAGAA GCGCATTTGA AGCATTTAGA AGCGCAGCAC 300

AAAGAATTTG TAAGAGATGA AAAACGCTAT TTGGAAAAGG AAAAAAAAGA GCTTGAAAAA 360

GAACGCCAAA TTTTAGAACA AGAGAGGGAA AATTTTAAAA AACAGCGCGC CATTTGTAAA 420

GAAGCTCAAG CCAAAGCGCT AGATGCGATG CTCAATTACA TGGCTTATAC CAAAGATGAA 480

ATTAAAAGCA TGATCTTAGA GCAACTAGAA GAGGAACTAG AAGCGCAAAA AAGCGCCTTG 540

ATCAGGCGTT ATGAAAAAGA AGCCAAAGAA GAGGGTAAGA AAAAATCGTA TGCCATTTTA 600 GCGGAAGCGA CAGCCCGTTT TGCGGGCGAT TATGCGACAG AGAATTTAAC AAGCCGTATC 660

GCTTTGCCTT GCTCAGATTA TGTGGGTCGT GTGATAGGCA AAGACGGGAA AAACATTGAA 720

GCGTTTAAAA AGATTAGTGG GGTGGATATA GAATTTAGCG AAGACAGTAG CGAATTGTGC 780

TTGTCCAGTT TCAATATTTA TCGGCGTGAA GTGGCGAGCG AGACGATTAA AATTTTAATA 840

GAAGACGGCC GTATCCAGCC TAACAGGATT GAAGAGGTTT ATCATAGAGT CGCGCGCAAC 900

ATGGAAAAAG AATTGCTTTC TGAAGGAGAG AGCGTGGTGC TAGAATTAGA GCTTGGAACT 960

ATGGAAGATG AGCTTAAAAT TTTAATAGGC AAAATGCGTT ATCGCTTTAG TTTTGGGCAA 1020

AACGCTTTAC AGCATTCTAA AGAAGTCGCT CTTTTAGCCG GCTTGATTGC AGAACAGCTT 1080

GGGGGGGATA AAAAACTCGC CAGAAGAGCC GGTATTTTGC ATGATATTGG TAAAGCGCTC 1140

ACTCAAGAGC TTGGGAGAGA CCATGTGAAT TTAGGGGTTG AGGTGTGCAA GCGCCATAAA 1200

GAAGACCCGG TTGTGATCAA TGCGATTTAT GCCCACCATG GGCATGAAGA AATCATGAGC 1260

GTGGAGTGCG CGAGCGTGTG CGCGGCTGAT GCGCTTTCTG CAGGGCGTCC GGGCGCTAGG 1320

AGAAAGAGCG ATGAAGAATA CGCTAAACGC ATGCAAGCTT TAGAAGAGAT CGCGTTAGAA 1380

TTTGATGGGG TGGAAAAGGC GTATGCGATG GAGAGCGGGC GAGAACTAAG AGTGATTGTC 1440

AAATCCAACC AAGTCAGGGA CAATCAAGTG CCTATTATTG CTAGAAAGAT CGCTAAAAGG 1500

ATAGAAGAGA GCACTCAGTA TGTGGGCGAA GTGGGCGTGC AAGTGGTGCG AGAAAATCGT 1560

TTCAAAACGA CCGCTACGCT CAAGCAATGA 1590

(2) INFORMATION FOR SEQ ID NO: 254:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 750 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...750

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 254:

ATGAAAAAAG GTAGTTTAGC AATCGTTTTA GGATCGTTAC TAGCAAGTGG GACGTTTTAT 60

ACGGCTCTAG CTGATGGAAT GCCTATGAAG CAACAGCACA ATAACATGGG TGAGTCTGTG 120

GAGTTGCATT TCCACTATCC TATTAAAGGC AAACAAGAGC CTAAAAATAA CCATTTAGTT 180

GTCTTAATCG ATCCTAAGAT AGAGGCTAAT AAAGTTATCC CTGAAAATTA TCAAAAAGAA 240

TTTGAGAAGT CTTTGTTCCT CCAACTGAGT AATTTTTTAG AGAGAAAGGG CTATAGCGTT 300

TCGCAATTTA AAGATGTTAG CGAAATCCCT CAAGACATCA AAGAAAAAGC GTTGCTCGTT 360

TTACGCATGG ATGGGAATGT GGCTATCTTG GAAGATATTG TAGAAGAGAG CGATGCGCTC 420

AGTGAAGAAA AAGTGATAGA CATGTCTTCA GGGTATTTGA ATCTGAATTT TGTTGAGCCA 480

AAAAGTGAAG ACATTATCCA TAGTTTTGGT ATTGATGTTT CAAAGATTAA GGCTGTGATT 540

GAAAGGGTGG AATTGCGGCG TACCAATTCT GGAGGTTTTG TCCCCAAAAC TTTTGTGCAT 600

AGGATCAAGG AAACCGACCA TGACAGAGCC ATTAAAAAGA TCATGAATCA AGCCTATCAC 660

AAAGTGATGG CGCATATCAC CAAAGAATTA AGCAAAAAAC ACATGGAACG TTATGAAAAA 720

GTTTCTAGTG AAATGAAAAA GCGAAAGTAG 750

(2) INFORMATION FOR SEQ ID NO: 255: (l) SEQUENCE CHARACTERISTICS

(A) LENGTH 357 base pairs

(B) TYPE nucleic acid

(C) STRANDEDNESS double

(D) TOPOLOGY circular

(ii) MOLECULE TYPE DNA (genomic)

(ill) HYPOTHETICAL NO

(iv) ANTI-SENSE- NO

(vi) ORIGINAL SOURCE-

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY. mιsc_feature

(B) LOCATION 1...357

(xi) SEQUENCE DESCRIPTION SEQ ID NO: 255:

ATGCAAAACA CCTTTAACTA CACCAACAAC GCTTTGAAAA ACAATGCTAA ATTAACCCCC 60

ACTGAAATGC AAGCCGAACA ATACTACCTC CAATCCACCC TTCAAAACAT TGAAAAAATA 120

GTCATGCTTA GCGGTGGCGT TGCGTCTAAC CCTAAACTAG TCCAAGCGTT AGAAAAAATG 180

CAAGAACCCA TTACTAACCC TTTAGAATTG GTAGAAAACT TAAAAAATTT AGAATTACAA 240

TTCAGCCAAT CTCAAAACAG CATGCTTTCT TCTTTGTCTT CTCAGATCGC TCAAATTTCA 300

AATTCTTTGA ACGCGCTTGA TCCCAGCTCT TATTCTAAAA ACGTTTCAAG CATGTAT 357

(2) INFORMATION FOR SEQ ID NO: 256:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 945 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...945

(xi) SEQUENCE DESCRIPTION: SEQ ID NO -256:

ATGGACTTAG ACAAACTCAA AGATTATAGG GCTTTAAGAA ACGCTATTTT AAGGCTATTG 60

CCTTATTTAG ATAGCGGTAT TACAGAGCTA ATTATGAATA AAGAAAAAGA AATTTGGCTC 120

TATAAGCTTA ATGGAGTAAG AGAAAAAGTC TTTGATGAAA ATTTAGACAA AGCCTTTATT 180

CTGGGGTTTG GGGAACAATT AGCGAGTTTT AGAGATTTGT TTTTTAATGC TAATTACCCC 240

ACCCTTAATA CTTCCATTCC TACTTCTAGA TACAGAGTGA GCATGAACCA CTTTGCTATT 300

AGTGCGGATA ATGAATTGAG TTTGAATATT AGAGTGCCAA GTGATAAAAA GTTTGATTTA 360 AAAGCTTTCA AGCTTTCTAG TATCTGTCAA TACGATTATG AGTATTTAAA AAACTTAATG 420

ATTGATGGCA AAAACTTACT CATTAGTGGA GGCACAGGCA GTGGAAAAAC GAGTTTTTTA 480

AACGCTCTAA TTGAGTTTAT CCCCAAACAC ACACGAATAG TAAGCGTTGA AGATAGCGAA 540

GAATTAGATT TAAGAGCGTT TGAAAATCAT AAATCCTTGT TAGTGGATAA AACTGAAAGC 600

TCTAAATTTA CATATGAAAA CGCCTTGAAT ATGGCAATGA GAATGTCTCC TGATAGGCTT 660

ATGGTAGGCG AGATTGACAC ACGAAATTCC ATGCTCTTTT TAAGATTTGG AAACACTGGG 720

CATAAAGGCA TGGTTTCTAC TTTACATGCA GATAGTGTGC ATGGGGTTAT AGAGGCGATT 780

GCTTTAAATT TACAAATGAA TAAAAGTGGT TTAGATGTCA ATGTAGCAAA AAAATTCTTT 840

AAAAGCAGTG TGGATGTTGT CGTTCAAATT GTATTAGATA AAGCCACTAA CACCAGATAC 900

ATTCAAGAAA TCTTACCAGC AAAAGATTTA AGAGATAGTC TATGA 945

(2) INFORMATION FOR SEQ ID NO: 257:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 435 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...435

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 257:

ATGAATATAT CGGTTAACCC CTATTTAATG GCGGTCGTTT TTGTAGTGTT TGTGTTGTTG 60

TTGTGGGCGA TGAATGTTTG GGTGTATAGG CCTTTGTTGG CTTTTATGGA TAACAGACAG 120

GCAGAGATAA AGGACAGCTT GGCTAAAATC AAAACGGATA ACACCCAAAG CGTGGAGATT 180

GGCCATCAAA TTGAGACTCT TCTTAAAGAA GCCGCTGAAA AGCGCAGGGA AATGCTAGCA 240

GAAGCGATTC AAAAAGCTAC AGAGTCTTAT GACGCTGTGA TCAAGCAAAA GGAGAACGAA 300

CTCAATCAAG AGTTTGAAGC GTTCGCAAAG CAATTACAAA ATGAAAAACA AATCTTAAAA 360

GAGCAATTGC AAGCGCAAAT GACGGTATTT GAAGACGAGT TAAACAAGCG TGTGGCTATG 420

GGTTTAGGGA GTTGA 435

(2) INFORMATION FOR SEQ ID NO: 258:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 276 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE

(A) ORGANISM Helicobacter pylori

(ix) FEATURE-

(A) NAME/KEY. mιsc_feature

(B) LOCATION 1...276

(xi) SEQUENCE DESCRIPTION. SEQ ID NO:258:

ATGGCTAGTG GCCTTTTTGA AAACGATGAA ATCAAAAACA ACAAAGCGCG AGATTTTTTT 60

TATAGCCATA GCTCCCTTAT TGTCTTTTTC CTCTTACTGC TTGGGTTTGG GTATTATTTA 120

GGGAAGTTGC TTTTTGGGGG TTCTTCTTTA GAGGTCTATT TGGATTTAAG AGACAAGCAT 180

GAACGATTGC AACAAGAAAT CACCGAATTG CAAAGCAAGA ATGTGCGCTT GCAAAAGCGT 240

TTGTTTGAGT TGAGGGAATT ACGGCCTAGA GATTAG 276

(2) INFORMATION FOR SEQ ID NO: 259:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 900 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...900

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 259:

ATGAAAAAAA ATATCTTAAA TTTAGCGTTA GTGGGCGCGT TGAGCGCGTC GTTTTTGATG 60

GCTAAGCCGG CTCATAATGC GAATAACTCT ACGCATAACA CGAAAGAAAC GACTGATGCT 120

TCAGCAGGCG TGTTAGCGAC AGTGGATGGC AGACCCATCA CCAAAAGCGA TTTTGATATG 180

ATTAAGCAAC GAAATCCTAA TTTTGATTTT GACAAGCTTA AAGAGAAAGA AAAAGAAGCC 240

TTGATTGAGC AAGCTATCCG CACCGCGCTT GTAGAAAATG AGGCTAAGGC AGAAAAGCTT 300

AATCAGACTC CAGAATTTAA AGCGATGATG GAAGCGGTTA AAAAACAGGC TTTAGTGGAA 360

TTTTGGGCTA AAAAACAGGC TGAAGAAGTG AAAAAGATCC AAATCCCAGA AAAAGAAATG 420

CAGGATTTTT ACAACGCCAA TAAAGATCAG CTTTTTGTCA AGCAAGAAGC CCATGCTAGG 480

CATATTTTAG TGAAAACCGA AGATGAAGCC AAAAGGATTA TTTCTGAGAT TGACAAACAG 540

CCAAAGGCTA AAAAAGAAGC CAAATTCATT GAGTTAGCCA ATCGGGATAC GATTGATCCT 600

AACAGCAAGA ACGCGCAAAA TGGCGGTGAT TTGGGGAAAT TCCAAAAGAA CCAAATGGCT 660

CCGGATTTTT CTAAAGCCGC TTTCGCTTTA ACTCCTGGGG ATTACACTAA AACCCCTGTT 720

AAAACAGAGT TTGGTTATCA TATTATCTAT TTGATTTCTA AAGATAGCCC TGTAACTTAT 780

ACTTATGAGC AAGCTAAACC TACCATTAAG GGGATGTTAC AAGAAAAGCT TTTCCAAGAA 840

CGCATGAATC AACGCATTGA GGAATTAAGG AAGCACGCTA AAATTGTTAT CAACAAGTAG 900

(2) INFORMATION FOR SEQ ID NO: 260:

(l) SEQUENCE CHARACTERISTICS: (A) LENGTH- 918 base pairs

(B) TYPE- nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY, circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL- NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...918

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:260:

ATGATAAAGA GTTGGACTAA AAAGTGGTTT TTGATTTTAT TTTTAATGGC AAGCTGTTTT 60

GGTCATTTGG TGGCTACAAC CGGTGAGAAA TATTTTAAGA TGGCTAATCA AGCCCTTAAG 120

AGAGGGGATT ACCATAGAGC GGTGGCTTTT TATAAGAGGA GCTGTAATTT GAGGATGGGG 180

GTTGGTTGCA CGAGTTTAGG CTCTATGTAT GAATATGGCG ATGGCGTGGA TCAGAATATT 240

TCAAAAGCCG TTTTTTATTA CAGAAGAGGG TGTAATTTGA GGAATCATCT CGCTTGCGCG 300

AGTTTAGGCT CTATGTATGA AGATGGCGAT GGCGTGCAAA AAGACTTTCC AAAGGCTATC 360

TATTATTATA GGAGAGGGTG CCACTTAAAA GGTGGGGTGA GCTGCGGTAG TTTGGGTTTT 420

ATGTATTTCA ATGGTACGGG CGTTAAACAA AATTACGCCA AAGCCCTTTC TTTTTCTAAA 480

TACGCTTGCA GTTTGAATTA TGGCATTAGT TGTAACTTTG TAGGGTATAT GTATAAGAGC 540

GCCAAAGGCG TGGAGAAGGA TTTGAAAAAA GCCCTTGCGA ATTTTAAAAG AGGGTGCCAT 600

TTAAAAGACG GGGCGAGCTG TGTGAGCTTG GGATACTTGT ATGAAGCCGG TATGGATGTC 660

AAACAAAATG AAGAGCAGGC TTTGAATCTT TATAAAAAGG GTTGCTCTTT AAAAGAAGGG 720

AGCGGTTGTC ATAATGTGGC GGTGATGTAT TACACGGGTA AGGGAGCTCC AAAAGATTTG 780

GAGAAAGCCA CTTCATATTA TAAGAAAGGG TGCGCTTTAG GCTTTAGTGG TAGTTGTAAG 840

GTGTTAGAAG TGATTGGCAA GGAGTCTGAT AATTTGCAAG ATGACGCGCA AAACGACACG 900

CAAGATAGCG TGCAATAA 918

(2) INFORMATION FOR SEQ ID NO: 261:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1509 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...1509 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:261:

TTGAAAATCT TTTTAGTTAT TCTAAGCGTC TTTTTTTTTA ATGGGTGTTT TGGGCTAGCC 60

TATAAGACTC CCATTTCAAA CCCCCCTATC TCTTATGACC CCTACACTAC CACCATTGGG 120

AGCTTGTATG CTAAAAATTT AAAAGAAAAC CCTAAACATA GTGCGGCCAT TCTTTTAGAA 180

GACGGCTTTG ATGCCTTGTT GCACAGAGTG GGTCTTATTA GAATGAGCCA AAAAAGCATT 240

GACATGCAAA CTTATATCTA TAAAAACGAC CTTTCTTCTC AAGTGATCGC TAAAGAACTT 300

TTAAACGCGG CCAATCGTGG GGTAAAAGTG CGCATCCTTT TAGATGACAA CGGGTTAGAT 360

TCAGATTTTT CAGACATCAT GCTTTTAAAT TTCCACAAAA ACATTGAAGT GAAAATCTTT 420

AACCCCTACT ATATCCGCAA TAAAGGCTTG CGTTATTTTG AAATGCTTGC GGATTATGAA 480

CGCATTAAAA AACGCATGCA CAACAAGCTT TTCATCGTGG ATAATTTCGC TGTCATTATA 540

GGGGGGCGCA ACATTGGGGA CAATTATTTT GATAACGATT TAGACACGAA TTTTTTAGAT 600

TTAGACGCTT TGTTTTTTGG GGGGGTTGCT TCAAAGGCCA AAGAAAGCTT TGAAAATTAT 660

TGGCGATTCC ACCGCTCTAT CCCTGTTTCA TTATTAAGAA CCCATAAAAG ACTCAAAAAC 720

AACGTTAAAG AAATCGCTAA GCTCCATGAA AAAATCCCTA TCAGCGCTGA AGACGCAAAC 780

GAATTTGAAA AAAAAGTCAA TGATTTTATA GAACGCTTCC AAAAATACCA ATACCCCATT 840 TATTATGGGA ATGCCATTTT TCTAGCCGAT TTGCCCGCCA AAATTGACAC GCCCTTGTAT . 900

TCGCCCATCA AAATCGCTTT TGAAAAAGCC CTTAAAAACG CTAAAGACTC CGTTTTTATC 960

GCTTCATCGT ATTTTATTCC AGGTAAAAAG ATAATGAAAA TCTTTAAAAA TCAAATTTCT 1020

AAGGGGATTG AATTGAATAT TCTTACCAAT TCCCTTTCAT CTACGGACGC TATCGTGGTC 1080

TATGGGGCGT GGGAAAGGTA TCGCAATAAA TTAGTGCGAA TGGGCGCGAA TGTCTATGAA 1140

ATACGAAACG ATTTTTTCAA CCGCCAGATT AAAGGGCGCT TTAGCACCAA ACATTCCTTA 1200

CACGGCAAGA CAATTGTTTT TGACGATGCC CTAACGCTTC TAGGGAGTTT TAATATTGAT 1260

CCGCGCTCTG CATATATTAA CACTGAAAGT GCGGTCTTGT TTGACAACCC GTCTTTTGCC 1320

AAAAGGGTGC GTTTGTCGCT TAAAGATCAT GCCCAACAAT CATGGCATTT AGTCTTGTAT 1380

CGGCATAGAG TGATTTGGGA AGCTACAGAA GAAGGCATCT TAATCCATGA AAAAAACTCG 1440

CCTGATACCT CTTTCTTTTT GCGTTTGATT AAAGAATGGT CTAAAGTCCT TCCTGAAAGA 1500

GAACTTTAA 1509

(2) INFORMATION FOR SEQ ID NO: 262:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 510 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...510

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 262:

TTGAAAAATC TCTCAACACT TCTGGTGTTT TTATTCTTTT GTTTGGGGTG TGTGAGCAAT 60

TTTAATGAAG ACACTTACAC GCTAGACTTA GTTTTAGAAA AAAAGATCCA AGCCAGTAGG 120

AAAGGCGAAA TCACCCAAGA TAATGTGCCT ATCATCACGG CTATCGCTAC GCATTTAAAC 180

GATGTGGATA GCGGCACTTA CTACGATCAT GAGTATTTTT TAGTGGAGAT TTTCACGCAA 240 AATAACGACT GGATAGATGA TGGCTATATT TCTTATGAAC TTTTTGGCAC AAAACCTACA 300

GGATCAGAAC CTTTATGGGT GCGAGAGATT ACAAGAGATG AATTTGATGG CATTTTAGAA 360

ACCACGAACC GGTGGAGCCG AGCCTTTTTG ATCGCTTTTG ACAAATTGGA TTATTTAGCG 420

GTGCAAGAAG CCAAACTAGA GCTTGATGCC TATAGTTTAG GCAAAATTGT TTTTAATTTC 480

GCTTACCAAG TCCCCTTACC TCAATTTTAA 510

(2) INFORMATION FOR SEQ ID NO: 263:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1536 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1536

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 263:

ATGAAAAAAC TTCTTTATAC CATGCTCGCG CTTCTTTTAA TCGGCCTTTT AACGGCCTAT 60

CTTATCCTTT TTACAGAATG GGGGAATAAG ATCATCGCTT CGTATATAGA GAAAAAAATC 120

AATCCGAACG AGCGTTATTT GAGCGTTAAA ACCTTTAAAT TGAGATTCAA CTCTTTGGAT 180

TTCAAAGCTC AAGCCAACGA TGATTCCACG CTCATTCTTA AGGGGGATTT CTCGCTTTTA 240

ACGCAAAGCG TAAATTTGGA TTACCACATA GACATTAAAA ATTTACGCTC TTTTAAGGAT 300

TTGATACCCT ACCCCTTAAG AGGGGCTATT GTTACTTCTG GGAATATCAA AGGGCATAGA 360

AAAGCCCTTG TAGTTCAAGG CGTCTCCAAT GTCGCTCAAT CCCACACTGC CTACAACGCC 420

CTTTTAGATG ATTTCAAGCT TTCTCACTTA AGTTTGAACG CAAAAGACGC CAATTTAGAA 480

GATTTGCTTT ATTTAATCAA CCGCCCCGCT TATGCGAACG CAAAAGTGTC CTTACAAGCG 540

GATTTTAACT CTCTAAAGCC CTTAGAAGGG CATTTGATCC TAACAGCTAA TAACGCTTTA 600

ATCAATAACG CCCTAATCAA TCAAATCTTT CATTTAAACC TTAAAGACAC GCTCGTTTTC 660

AACCTCTCGC ACTCAAGCGA TTTTAAAGGA AACAAAGCCA TCAGCGATAC CACCCTAACT 720

AGCCCTTTAG TTAATTTCAC AGCCCTAAAA AGCGAATATT CTTTCCCTGC TTTAAAACTC 780

AACGCCCCCT ACACTTTAGA AATACCCCAT CTAGCCAAAC TCCAAAACAT TACCAACCAC 840

CCCTTAAAAG GGAGCTTGAC TTTAAAAGGC GATATAGAGC AAAGCCCTAA ACTCTTAAAA 900

GTCAGTGGCC ATTCAAATTT ACTAGACGGC GCGCTAGACT TCACGCTTTT AAATAAAGAT 960

TTGAAAGCCC GTTTTTCCAA TATTTCCACT TCAAAAGCCT TAGATTTATT CCATTACCCT 1020

AAATTTTTCC AATCCATTGC AGACGCTAAC TTGGATTATG ACCTTATCTC TAAGCAAGGC 1080

GTGTTGAAAG CCAATCTCAA GAACGCAAGA TTCCTCAAAA ATGCATTCAG CGATTTCCTC 1140

TATTCCATTT CTCGTTTTGA TATTACTAAA GAAATTTATC ACGATGCCAA TCTAGTAAGC 1200

CAAATCAACC AGCAACGCCT GCTCTCTGAT TTGAGTTTAA AAAGCCCCAA AACCCAATTG 1260

AAAATCCATA ACGGCTTGTT GGATTTAAAC ACCAAGCAAA TGGACATACT CATGGATGCG 1320

GAAATCTTAA AATTCATCTT TAAAATGAAA CTTCAAGGCA GCATGCACCA GCCAAAATTT 1380

TCCCTCATTT TAAACGAAAA AGCCATTCAG CAAAACCTGC AACAAGGCTT GAAAGAAATC 1440

CTTAAAAACG ACACCCTTAA AAAAGGTTTA GATCATTTGC TTAAAGATGA TAAACTCAAA 1500

GAAAAGCTTG AAAAAGGGCT TAAGGGGCTT TTTTAA 1536

(2) INFORMATION FOR SEQ ID NO: 264: li) SEQUENCE CHARACTERISTICS.

(A) LENGTH 483 base pairs (3) TYPE, nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...483

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:264:

ATGTTTGGCA TGGGCTTTTT TGAAATCCTT GTGGTGTTGA TTGTAGCGAT TATTTTTTTA 60

GGACCAGAAA AATTCCCTCA AGCTGTCGTG GATATAGTGA AATTTTTTCG CGCGGTTAAA 120

AAAACGCTCA ATGACGCTAA GGACACTTTA GATAAAGAAA TCAATATTGA AGAAATCAAA 180

AAAGAAACCT TAGAGTATCA AAAACTCTTT GAAAACAAAG TGGAGAGTCT TAAAGGCGTT 240

AAGATTGAAG AATTAGAAGA CGCTAAAGTA ACTGCAGAAA ATGAGATTAA AAGCATTCAG 300

GATTTGATGC AAGATTATAA ACGCAGCTTA GAAACCAACA CGATTCCTAA CCATTTAAAT 360

GAAGAAGTTT CCAATGAAGA AGCTTTAAAT AAAGAAGTTT CAAGCGATGA ATCTCCTAAA 420

GAAGTCCAAT TAACAACCGA TAACAACGCC AAAGAACACG ACAAAGAAAA AGAGCATGTT 480

TGA 483

(2) INFORMATION FOR SEQ ID NO: 265:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 243 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...243

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 265:

ATGTTAAGAA TTTTAATCCC CTTACTCATT ATTGTGTGGG TTTTATGGCG TTTGTTTTTG 60 AGGCAAAAAC CCCACAAAGA TGACCACAGA GACAACCACT CTTACACGCA ACAAACCCCC 120 AAAGAATTAG AAGATCACAT GATTGTATGC TCTAAATGCC AAACTTATGT CTCTAGTAAA 180 GACGCCATTT ATAGTGGGGC GGTAGCCTAT TGCAGTGAAA CTTGTTTGAA GGATAAGGGG 240 TAA 243

(2) INFORMATION FOR SEQ ID NO: 266:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 645 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...645

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 266:

TTGGATGGTT TGAAAAAAGA AAGACAAGGA TTTTACAAGC AAGTGCATTA TTTAAGAATT 60

TTAATACTGA GTATGAGTTT TTTAAATATT TTAAATGCTG AAAATTTGAG TTACATGTCT 120

TCTTCTTATC AAATAGGCAC GGTGTTTATG CGCCCCTTAA ACACCAACAA ACTTTTACAA 180

GGGGCTTCAA TCCTTCAAGG CTATGAAGTG AATCCTAAAA ACGACTGGGC TTATTCTAGG 240

TATTATTTCT TTATAGATTA TGGTAATGTG CTTTTCAATA ACGATTCCAC TTTGCAAGCG 300

AACATGTTCA CTTATGGGGT GGGAGGAGAT TTTATGGTCG CTTACGCTAA AAACCCTATC 360

AACCGCTGGG CTTTTTTCTT TGGTTTGCAA CTAGCGGCTA ACACATGGAT ACTCAATAAT 420

AAAGTCAAAG ATTTGGTGGT GAATACTTGG GATTCATTGA AAGATTTCAA TTTTCATAAC 480

ACTTATTTTA GGGCTATCGG GAAATTTGGG GTGCAGTTTC GCACGATCGT TTTGTATCAT 540

AAGGTGGATG TGGAAATTGG CATGAAAATC TTTTTAACGC CTGAAAGGCG CAGCTTGTTT 600

GAAAGGAGTT TTTTGTTTTT TGTTTCGCAC TCGTGGCATT TTTAA 645

(2) INFORMATION FOR SEQ ID NO: 267:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 336 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE: (A) NAME/KEY: misc_feature (3) LOCATION 1...336

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:267:

ATGAAACCAA CGAACGAACC TAAAAAACCT TTTTTTCAAA GTCCCATTGT TCTTGCGGTT 60

CTTGGAGGGA TTTTACTCAT TTTTTTCCTA CGCTCTTTCA ATTCTGATGG CAGTTTTTCG 120

GACAATTTCT TAGCTTCTAG CACTAAAAAT GTGAGCTACC ATGAAATCAT ACAGCTCATC 180

AGCAATCATG AAGTGGGAAA TGTGAGTATC GGTCAAACTT TGATCAAAGC CAGCCATAAA 240

GAGGGCAATA ATCGTGTGAT TTATATCGCT AAACGAGTGC TGATCTACCT TAGTGCCTTT 300

GTTAGACGAG AAAAAAATCA ATTATTCTGG TTTTGA 336

(2) INFORMATION FOR SEQ ID NO: 268:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 624 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...624

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 268:

ATGTTAAGGG TTTTAAGCGT TGGTGTTGTT TTTATTTTAC TAGGGTGTCA GTTTTTCAAC 60

AAAACGACTC TGCATTTAAA ATATAAGGAT TACCCCAAAA ACAGCCCTTT AAAAACCGCT 120

TCCACTTTAA CCCCCCCTAA AATCTTTTTT AACGCTCATT TTGTGCCGCC CTTTTACCAA 180

AAAGAATTTA AAAAAGCGCT CGCCCAGCAA ATCGCTTATT TTTTAAAGGA TAAAAGCGCT 240

CTCACTTTCA ATATTTCAGG CAATGTTTTT TTTTCTTTTG AAGAGAGTCC TAAGGATTTA 300

AAAGCCATTA AAGAAAGGCT TAAAAAGACG ATTGAGCCTA ACACTGACCC AAAAGCCGTC 360

ATGCGTTTTT TAAACCTTCA AGCGAGCTTG ATTTTAGAAT GTGTCCCACA AACCGCTTGC 420

CCATTTGACA CCCTTTTAAT CCCCACCGCT CTCAGCGTGC CTATTGATTA CGCCAATCGT 480

TTGGGCGATA ACCCCTCTCT TTTTCCCCAA GAAGATAAAT CCTATCATAA CGCTTTAATC 540

AAAGCCCTTA ATAAGGCTTA CTATTCTCTT ATGGAGGGTT TAGAAAAGCG TTTGAACGCT 600

ATAGAAAATG CGGCATGGCT TTAG 624

(2) INFORMATION FOR SEQ ID NO: 269:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 528 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (m) HYPOTHETICAL. NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY. mιsc_feature

(B) LOCATION 1.. 528

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:269:

ATGAAAAATC AAGTTAAAAA AATTTTAGGG ATGAGTGTGG TAGCAGCGAT GGTGATCGTA 60

GGTTGTAGCC ATGCCCCAAA ATCAGGTATC AGTAAAAGCA ATAAGGCATA CAAAGAAGCG 120

ACTAAAGGCG CTCCTGATTG GGTTGTAGGG GATTTGGAAA AAGTGGCGAA GTATGAAAAA 180

TATTCAGGGG TCTTTTTAGG AAGGGCTGAA GATTTGATCA CTAATAATGA TGTGGATTAT 240

TCTACGAATC AGGCTACAGC CAAAGCTAGG GCTAATTTAG CGGCGAATCT AAAGTCCACT 300

TTACAAAAAG ATTTGGAAAA TGAAAAAACC AGAACGGTAG ATGCTTCTGG TAAAAGGTCC 360

ATAAGCGGCA CTGATACTGA AAAAATTTCT CAATTAGTGG ATAAGGAATT GATCGCTTCT 420

AAAATGCTTG CCCGCTATGT CGGTAAAGAT AGGGTTTTTG TTTTAGTGGG CTTGGATAAG 480

CAAATTGTGG ATAAAGTGCG CGAAGAGTTA GGCATGGTTA AAAAGTAG 528

(2) INFORMATION FOR SEQ ID NO: 270:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 267 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...267

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 270:

ATGAAAAAAA TCGTTGTGAG TTTATGCGTG GCGTTAGGTT TTTTAAGCGC GGATCCAGCG 60

CAGGCCAATA AAGCGATCAG TGATGCGGAT TTGATTGAAG AGATAAGGGA CTTGAAAAAA 120

ATCATCAGCG CACAAAACAC GGAGATTAAC CAATTAAGAA AAGTGCAAGA AGTCTTATCT 180

GGGCAATTAG GGGACATGCG TAAGGATATA TTAAGCACTA GAGATTACTG TATCAGCTTA 240

AGGCCTTATA TTTATAATTG GCGCTAG 267

(2) INFORMATION FOR SEQ ID NO: 271:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 774 base pairs

(B) TYPE: nucleic acid (C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL : NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...774

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:271:

TTGAATAGCG GCTCTAACGC TTCATTGTAT GGCACAAGCG CCGGCGTAGA CGCTTTCCTT 60

AACGGGAATG TGGAAGCCAT TGTGGGCGGT TTTGGAAGCT ATGGTTATAG CTCCTTTAGC 120

AATCAAGCGA ACTCTCTTAA CTCTGGGGCC AATAACGCTA ATTTTGGCGT GTATAGCCGT 180

TTTTTTGCCA ACCAGCATGA ATTTGACTTT GAAGCTCAAG GGGCGCTAGG GAGCGATCAA 240

TCAAGCTTGA ATTTCAAAAG CACTCTATTA CAAGATTTGA ATCAAAGCTA TAATTACTTA 300

GCCTATAGCG CCACAGCAAG AGCGAGTTAT GGTTATGACT TCGCGTTTTT TAGGAACGCT 360

TTAGTGTTAA AACCAAGCGT GGGCGTGAGC TATAACCATT TAGGTTCAAC CAACTTTAAA 420

AGCAATAGCC AATCACAAGT GGCTTTAAAA AATGGCGCGA GCAGTCAGCA TTTATTCAAC 480

GCTAACGCTA ACGTGGAAGC GCGTTATTAT TATGGGGACA CTTCATACTT TTATTTGCAT 540

GCGGGAGTTT TACAAGAGTT CGCTCACTTT GGATCGAATG ATGTGGCGTC TTTAAACACC 600

TTTAAAATCA ATGCCGCTCG CAGTCCTTTA AGCACCTATG CAAGAGCGAT GATGGGTGGG 660

GAATTGCAAT TGGCTAAAGA AGTGTTTTTG AATTTGGGCG TGGTTTATTT GCACAATTTG 720

ATTTCCAACG CAAGCCATTT CGCTTCCAAT TTAGGAATGA GGTATAGTTT CTAA 774

(2) INFORMATION FOR SEQ ID NO : 272:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 852 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...852

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 272:

ATGTTTGAAG ATTTTTATCG CACTACCCTC TCTTTTTTAA GGTCTTTATT GCTTTTATTG 60 GGTTTATTGT TGCCGTTTTC GCTTTGTATA GCTGATGAAT ATATTAGCAT AAGTGATGAT 120 TGGGATGAAA GGGCGCGAAA TCAGTGGGAT GAAACTGCGC GAAATCATAA GACATATTAT 180

TTTGAAAATG GTTTAGACCA TTTTAATCAA GGCCAATACA AGCAAGCCTT TAAAGATTTT 240

AAATTGGCGC AAGAATACAG CATCGGGCTT GGCAACGTTT ATTTAGCCAA AATGTATTTG 300

GAGGGAAAGG GCGTGAAAGT GGATTACAAA AAAGCGCAAT TCTATGCACA AAACGCTATC 360

AAAGGGTATG GGAGCGGGTT GTTAGGGGGC GCTCTTATTT TAGGACGCAT GCAAGCAGAA 420

GGCTTAGGGA TGAAAAAGGA TTTGAAACAA GCACTCAAGA CTTACAGGCA TGTGGTTCGC 480

ATGTTTTCTA ATAAAAGTGC AAATTTTGCT AACAAATTTG GATCAAACCT TGCGGAATTT 540

ACTAGTATGC TTATTGGATC GCGATTCATT GATCTTTCAG GTTTGAGCGC GAATCCTATA 600

AAATTTGGAA ATAAATTTGG AATACTTGTT AAGAAAGCCC TTCAAATCAA AGATAATACA 660

CTTTCTTGGG AAGACATTGC TGAAATTTCA AGCAATATTA TTTTACTCAA ACAACAAATG 720

GGGGAAATCC TTTATAGGAT TGGGATCGCT TATAAAGAAG GGCTTGGCAC TAGAAAGAAA 780

AAGGACAGGG CTAAAAAATT CTTGCAAAAA TCCGCAGAAT TTGGCTATGA AAAAGCCATG 840

GAAGCTCTGT AG 852

(2) INFORMATION FOR SEQ ID NO: 273:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2361 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...2361

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 273:

TTGTGCAAAA TTCCACTTTC TCTAACGCTA ATGGAGGCAC GCTCAGTTTT AACGCAGGAA 60

ATTCGCTCAT TTTTGCCGGA AACAACCACA TCGCTTTCAC TAACCATTCT GGAACGCTCA 120

ATTTGTTGTC TAATCAAGTT TCTAACATTA ACGTCACCAT GCTTAACGCA GCAACGGCCT 180

AAGATTAACG CCACTAATAA CAATGTTTCC GTGTCTCAAG GCAATCTGTT TATCAACGCT 240

AGCTGCGTGC AACAAAGCGA TCCAACGACA GCTAGCGCCA CAAACCCTTG CACCACCGCT 300

CAAAATAACG CTTCTTCTAG TAATGCGTCA AACAACGCGC CAATCGCCTT AAATAATAAC 360

GATGAAAGCT TGGTGGTTAC GGCGAATGGT TTCAATTTTT CAGGCAATAT TTACGCTAAC 420

GGGGTGGTTG ATTTTTCAAA AATTAAAGGC TCTGCAAACG TTAAAAACCT GTATCTTTAC 480

AATAACGCTC AATTCCAAGC CAACAACCTC ACGATTTCCA ACCAAGCGGT ATTAGAGAAA 540

AACGCTAGCT TTGTAACGAA TAACTTAAAC ATTCAAGGAG CGTTTAACAA CAACGCCACG 600

CAAAAAATAG AGGTGCTTCA AAATTTAGTG ATCGCTTCAA ACGCTTCTTT AAGCACCGGG 660

ATTTATGGGT TAGAAGTAGG GGGGGCATTG AATAATTTGG GAGCGATCCA TTTTAATTTA 720

GAAAATTCTC AAACGCCTGT AAATCCGCTC ATTCAAGTAG GGGGGATCAT TAATCTCAAC 780

ACCACCCAAA CGCCTTTTAT GAATGTCAGC GTGGCTAATG GCGGAACTTA CACTTTATTA 840

AAAAGCAGCC GTTATATTGA TTACAATATC AACCCTAACA GCTTGCAATC GTATTTGAAG 900

CTCTATACCT TAATCAATAT CAACGGAAAC CACATAGAGG AAAAAAACGG CGTATTGACT 960

TATTTGGGCC AACGGGTTTT ATTACAAGAT AAGGGGTTAT TATTGAGTGT AGCACTACCT 1020

AACTCAAACA ACGCCTCTCA AAACAACATT TTAAGCCTTT CTGTCCTTCA CAACCAGATT 1080

AAAATGTCTT ATGGTAATAA AGTGATGGAC TTTACCCCTC CCACCTTACA GGATTACATT 1140

GTGGGCATTC AAGGACAAAG CGCACTCAAT CAAATTGAAG CTGTTGGGGG GAATAACGCT 1200 ATCAAGTGGC TTTCAACATT GATGATGGAG ACTAAAGAAA ACCCGCTTTT TGCGCCGATT 1260

TATTTAGAAA ACCACTCTTT AAATGAAATC TTAGGCGTAA CAAAAGATCT TCAAAACACC 1320

GCAAGCTTGA TTTCTAACCC TAATTTTAGA AATAACGCTA CCAGCCTTTT AGAAATGGCG 1380

AGTTACACCC AACAAACCAG CCGTTTGACA AAACTCTCTG ATTTTAGGGC TAGAGAGGGA 1440

GAGTCCAATT TTTCAGAGCG CTTGTTAGAG CTTAAAAACA AGCGTTTTAG CGATCCTAAC 1500

CCTAGTGAGG TTTTTGTCAA ATACTCTCAA CTCAGCAAAC ACCCCAATAA CCTTTGGATT 1560

CAAGGGGTGG GAGGAGCGAG CTTTATTTCT GGGGGCAATG GCACGCTTTA TGGCTTGAAT 1620

GTGGGCTATG ACCGATTGGT TAAAAGCGTG ATCCTTGGGG GTTATGTGGC TTATGGCTAT 1680

AGCGGTTTTA ACGGGAACAT CATGCATTCT TTGGCTAATA ATGTGGATGT GGGGATGTAT 1740

GCGAGGGCTT TTTTGAAAAG AAACGAATTC ACTTTGAGCG CGAATGAAAC TTATGGAGGC 1800

AATGCGAGTC ATATCAATTC TTCTAATTCC TTGCTCTCTG TGTTGAACCA ACGCTACAAC 1860

TACAACACCT GGACAACGAG CGTGAATGGG AATTACGGCT ATGATTTCAT GTTCAAACAA 1920

AAAAGCGTGG TGCTAAAACC TCAAGTGGGC TTGAGCTATC ATTTCATAGG CTTGAGCGGG 1980

ATGAAAGGTA AAATGCAAAA TCCAGCTTAC CAACAATTCG TCATGCATTC AAACCCTTCT 2040

AACGAATCGG TTTTAACGCT CAACATGGGG TTAGAGAGCC GTAAATATTT TGGTAAAAAT 2100

TCCTATTATT TTGTAACGGC GAGGTTGGGT AGGGATCTTT TGATCAAAGC TAAAGGCGAC 2160

AATGTGGTGC GTTTTGTGGG TGAAAACACT TTATTGTACC GCAAGGGGGA AATTTTTAAC 2220

ACTTTTGCGA GCGTGATCAC AGGAGGCGAA ATGCATTTGT GGCGTTTGAT GTATGTGAAT 2280

GCGGGGGTGG GGCTTAAAAT GGGCTTGCAA TACCAAGATC TTAATATCAC TGGGAATGTG 2340

GGCATGCGAG TGGCGTTTTA G 2361

(2) INFORMATION FOR SEQ ID NO: 274:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1446 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1446

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 274:

ATGTTTAGAA AACTAGCAAC CTCTGTATCG CTCATAAGCC TACTAATCTC CAACGCTCTT 60

TATGCTAAAG AAATAAGTGA AGCCGATAAG GTCATTAAGG CCACTAAAGA AACTAAAGAG 120

ACCAAGAAAG AGGCTAAACG CCTCAAAAAA GAAGCTAAAC AGCGCCAACA GATCCCTGAT 180

AATAAGAAAC CTCAATATGT CTCTGTTGAT GACACAAAAA CTCAAGCGCT TTTTGATATA 240

TATGACACTT TGAATGTGAA TGACAAAAGC TTTGGGGATT GGTTTGGTAA TAGCGCTTTG 300

AAAAACAAAA CTTATCTCTA CGCTATGGAT CTATTGGATT ATAACAACTA CTTATCCATA 360

GAAAACCCTA TTATCAAAAC AAGAGCGATG GGAACTTATG CAGATCTGAT TATCATCACA 420

GGTTCGTTAG AACAAGTCAA TGGGTATTAC AATATTCTAA AAGCGCTCAA CAAACGCAAC 480

GCTAAGTTTG TGTTAAAAAT CAATGACAAA ATACCTTATG CCCAAGCGAC TTTTTTGAGA 540

GTGCCAAAAA GAAGCGATCC CAACGCCCAC ACGCTTGATA AGGGAGCGTC AATTGATGAA 600

AGCAAGCTTT TTGAACAACA AAAGAAAATG TATTTCAACT ACGCCAACGA TGTGATCTGC 660

AGACCCAACG ATGAAGTGTG TTCGCCCCTA AGAGATGAAA TGGTAGCTAT GCCCACTAAC 720

GATAGCGTTA CTCAAAAACC CAATATCATT GCTCCTTATA GCCTGTATAG ACTAAAAGAG 780 ACAAATAACG CCAATGAAGC CCAACCATCA CCTTATGCCA CTCAAACCGC TCCTGAAAAC 840

AGCAAAGAGA AGCTCATAGA AGAGCTAATC GCCAACTCCC AACTCATAGC CAATGAAGAA 900

GAGAGGGAAA AGAAACTCTT AGCAGAAAAA GAAAAACAAG AGACTGAATT GGCTAAATAC 960

AAGCTCAAAG ATTTAGAAAA TCAAAAGAAA CTAAAAGCTT TAGAAGCAGA GTTGAAAAAG 1020

AAAAACACTA AGAAACCTAG AGTAGTGGAA GTGCCTATTC CTCCTAAAAC AAGTGATTCT 1080

GATGAAACAA TGAGAGTTAT CAAAGAAAAA GAAAACTATA ATGGGTTATT AGTGGATAAA 1140

GAGACCACGA TCAAAAGAAG CTATAAGGGG ACTTTGATCA GTGAAAATTC TTACAGCAAA 1200

AAAACACCCA TCAACCTTGA GGACTTGAGA AGCTTAGAAG AAGAAATTAA GAGCTACTAT 1260

GTCAAGTCTA ATGGCTTGTG TTACGCTAAT GGCATTAACC TCTATGTAAA AATCAAAAAC 1320

GATCCCTACA AAGAGGGAAT GCTGTGTGGT TATGAGAGCG TTCAAAAACT GCTTTCACCA 1380

CTAAGGGACA AGCTCAAATA CGACAAGCAG AAGTTACAAA AAGCGTTACT GAAAGATTTA 1440

AAGTAA 1446

(2) INFORMATION FOR SEQ ID NO: 275:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 180 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...180

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 275:

TTGCTTTCCC GGTCTATGCC CAAAATTCAC GCCGTTTTCA AAGCTTTTAT CCCTATTCCA 60 TTCGCCCTCT TCGCTATCCA CTTCGTAGTA TTGGGAATTG GAAGCGTCTT TAATCTTAAT 120 AGAATCAAAG ATAAAAAATT CATTCTCCGC GCCAAAATAA GCCACATCGC CCAAGCCTAA 180

(2) INFORMATION FOR SEQ ID NO: 276:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 792 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori ( ix ) FEATURE :

(A) NAME/KEY: misc_feature

(B) LOCATION 1...792

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 276:

ATGAGAAAAA CGATTTCAGC GTTGTTTTTA TCAGCGTGTA TAGGGTTATC GTCTGTTCAT 60

GCGAGTAACG CTTTGATTTT ACAAACAGAT TTTAGCCTAA AAGATGGGGC CGTCTCGGCG 120

ATGAAAGGCG TCGCTTTCAG CGTTGATTCT AATCTTAAAA TCTTTGATTT AACGCACGAA 180

ATCCCCCCGT ATAACATTTG GGAAGGCGCT TACCGCTTGT ATCAGACCGC TAGTTATTGG 240

CCAAAAGGCT CGGTATTTGT GAGCGTAGTG GATCCGGGCG TAGGCACTAA TCGTAAATCG 300

GTGGTATTGA AAACTAAAAA CGGCCAGTAT TTCGTCTCTC CAGATAACGG CACGCTGACT 360

TTGGTAGCGC AAACTTTGGG GATTGATAGC GTGCGTGAAA TTGATGAAAA AGCCAACCGC 420

TTGAAAGGTT CTGAAAAATC CTATACTTTC CATGGCCGTG ATGTGTATGC TTACACTGGG 480

GCGCGCTTGG CTTCTGGGGC GATCACATTC GAGCAGGTCG GGCCAGAGCT TCCTATAAAA 540

GTTGTTGAAA TTCCTTACCA AAAAGCGAAA GCCACAAAAG GGGGAGTGAA AGGCAATATC 600

CCGATTTTGG ATATTCAATA TGGCAATGTT TGGAGCAATA TCAGCGATAA ACTGCTCAAT 660

CAAGCAGGGA TCAAACGAAA CGATACAGTG TGTGTAACTA TTTTAAAAAT TCCAAGAAAC 720

AATACGAAGG GAAAATGCCG TATGTCGCGA GCTTTGGCGA TGTGCCAGAA GGCCAGCCGT 780

TGGTCTATTT AA 792

(2) INFORMATION FOR SEQ ID NO: 277:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 345 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...345

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 277:

ATGAATATCA AAACCCATTC TTCAAATGAA AAAGAACGCT TTGTACGCAT AGAAGAGGAC 60

GAAAAGAAAG AATTATTCGC CGAAGCTACA AATGAAAATC CGCACGGCCT TTCTTTAATG 120

GCTTTAATAG GGGTGTTGGT TTTTGGGGGT GCGTTTTTAG CCTTATTAGT GCCTAAAATC 180

TATTTAAGCA ATAATATCTA TTATATTAGC CGTAAAATTA ATACCCTAGA AGATCAAAAA 240

CGCCTGCTTT TAGAAGAACA GCAAATCCTA AAAAACGAAT TAGAAAAAGA GCGTTTTAAA 300

TACTACATAG AGAATAGTGA AAATATTGGC GATATTGCGT TTTAA 345

(2) INFORMATION FOR SEQ ID NO: 278:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2826 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double (D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...2826

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 278:

TTGCAACATA AAACCATTAT GGATAAGATC ATTATTCAAG GGGCTAGGGA AAACAATCTC 60

AAAAATATCT TTTTAGAAAT CCCTAAAAAC CAATTTGTTG TTTTTACCGG ATTAAGCGGT 120

TCGGGTAAAT CCACTCTGGC GTTTGACACT CTATACGCTG AAGGGCAAAG GCGCTATTTA 180

GAGAGTTTGT CTAGTTATGC GAGGCAATTT TTAGACAAAG TGGGTAAGCC TAATGTGGAT 240

AAAATTGAAG GCCTAACCCC AGCGATCGCT ATTGATCAAA AAACCACTTC TAAAAACCCT 300

AGATCCACTG TGGGGACGAT CACTGAGATT TATGATTATT TAAGGTTGTT GTTTGCAAGG 360

GTTGGGGAGC AATTTTGCCC CACATGTTTA GAGCCTATTA GTTCTATGAG CGCGAGCGAT 420

ATCATTTCTC AAATCTGTCA TTTAGAAGAA AATTCTAAAA TCATTATTCT AGCCCCCATT 480

ATTAAAGATA AAAAAGGTTC GTTTAACGAT AAATTAGAGA GTTTGCGTTT GAAGGGGTAT 540

GTGAGGGCTT TTGTTGATGG GGTGATGGTG CGTTTAGATG AAGAAATCCA TTTGCACAAA 600

ACCAAAAAAC ACACCATTGA AGCGGTGGTG GATAGGGTGG TTATCAATAG CGAAAATGCT 660

TCACGGATCG CTAGCGCGGT AGAAAAAGCC CTTAAAGAAA GCTATGGGGA ATTAGAAGTG 720

GAAATCTTGC AAGACAACGC ACCAAGTATT AGGAAGCATT ACAGCGAGCA TAAGGCATGT 780

TTTAAGTGCA AGATGAGTTT TGAAGAATTA GAGCCTTTGA GTTTTTCCTT CAATTCGCCT 840

AAAGGGGCGT GCGAAAGTTG TTTGGGTTTA GGGACAAAAT TTAGCTTAGA TATTAGTAAG 900

ATTTTAGATC CTAACACGCC TTTAAATCAA GGAGCGATTA AAGTGATTTT TGGGTATAAC 960

CGCAGTTATT ACGCTCAAAT GTTTGAAGGC TTTTGCACTT ATAATGGCAT TGACAGCGCG 1020

CTTTGTTTCA ACGAATTGAA CAAAGAGCAG CAAGACGCTC TTTTGTATGG GAATGGCACT 1080

GAAATCAGCT TTCATTTTAA AAACAGCCCC TTGAAACGCC CCTGGAAAGG CATTATCCAA 1140

ATCGCTTATG ACATGTTTAA AGAGCAAAAG GATTTGAGCG ATTACATGAG CGAAAAAACC 1200

TGTTCTTCGT GTAATGGGCA TCGCTTGAAA GCCTCAAGTT TGAGCGTCCA AGTCGCTGGC 1260

TTGAAAATGG CGGATTTTTT AACTAAGCCC ATTGAAGAAG TCTATCATTT TTTTAATGAT 1320

CCCACGCATT TTAACTATCT TAACGAGCAA GAAAAAAAGA TCGCTGAACC CATTTTAAAA 1380

GAGATTTTAG AAAGGGTGTT TTTTTTATAC GATGTGGGGC TAGGGTATTT GACTTTGGGG 1440

AGGGATGCGC GAACGATTAG CGGAGGGGAG AGCCAAAGGA TACGAATCGC CAGTCAAATC 1500

GGGAGCGGTT TGACAGGGGT TTTGTATGTT TTAGACGAGC CTAGCATTGG CTTGCATGAA 1560

AAAGACACGC TCAAACTCAT CAACACCCTT AGGAATTTAC AAAAAAAGGG GAACACGCTC 1620

ATTGTCGTAG AGCATGATAA AGAGACGATT AAGCATGCGG ATTTTGTTGT GGATATTGGG 1680

CCAAAGGCTG GAAGGCATGG GGGTGAAGTG GTTTTTAGCG GGAGCGTAAA AGATTTATTG 1740

CAAAATAACC ATTCTACCGC CTTGTATCTC AACGGCACTA AAAAGATTGA GCGCCCCAAA 1800

TTTGAACCCC CTAAAGAAAA GCATTTTTTA GAAATTAAAA ATGTCAATAT CAATAACATT 1860

AAGAATTTGA GCGTTCAAAT CCCCTTAAAA CAATTGGTGT GCATTACGGG GGTGAGCGGG 1920

AGCGGTAAAA GCTCGCTGAT TTTACAAACC CTTTTACCCA CCGCTCAAAC CCTTTTAAAC 1980

CATGCTAAAA AAAATCAAAG CTTGAATGGG GTGGAGATTG TAGGGTTGGA GTATTTGGAT 2040

AAAGTGATTT ATTTAGATCA AGCCCCCATA GGCAAAACCC CACGAAGCAA CCCCGCCACT 2100

TACACGGGAG TGATGGATGA AATCAGGATT TTATTTGCCG AGCAAAAAGA AGCTAAAATT 2160

TTAGGCTATA GCACGAGCCG TTTCAGCTTT AATGTTAAAG GAGGGCGGTG TGAGAAATGC 2220

CAAGGCGATG GGGATATTAA AATAGAAATG CACTTTTTGC CTGATGTGTT AGTCCAATGC 2280

GATAGCTGTA AGGGCGCTAA ATACAACCCC CAAACTTTAG AAATCAAGGT GAAAGGCAAA 2340

TCCATTGCTG ATGTGTTGAA CATGAGCGTG GAAGAAGCTT ATGAATTTTT TGCTAAATTC 2400 CCTAAAATCG CTGTGAAGTT AAAAACGCTT ATAGATGTGG GCTTAGGCTA TATCACTTTA 2460

GGGCAAAACG CTACGACTTT AAGTGGGGGG GAGGCTCAAA GGATCAAATT GGCTAAAGAA 2520

TTGAGTAAAA AAGACACAGG CAAAACCCTT TATATTTTAG ATGAGCCTAC CACCGGTTTG 2580

CATTTTGAAG ATGTGAATCA CCTTTTACAA GTCTTGCATT CTTTGGTGGC GTTAGGCAAT 2640

TCCATGCTAG TGATTGAGCA TAATTTAGAC ATCATCAAAA ACGCTGACTA CATTATAGAC 2700

ATGGGGCCTG ATGGGGGGGA TAAGGGCGGG AAAGTCATTG CGAGCGGCAC GCCTTTAGAA 2760

GTGGCGCAAA ATTGCGAAAA AACCCAAAGC TATACGGGAA AATTTTTAGC TTTGGAATTG 2820

AAATAG 2826

(2) INFORMATION FOR SEQ ID NO: 279:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 252 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...252

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 279:

ATGAATTACG ATGTTTTAAT GGGATTTTTA GCACTAATCT TGCTAATTCT TTGGTATGCC 60

TATGGATTAA GGCAATATCT TAAATTAAAA GATAAGAATA AGAGATTAAA AGAGAAATTA 120

CAACGCTGTA ATTGTAATAT TAAAATTCCT AGTATTCTTG AAATGGCGCA TAAACCTATC 180

ATTATGGATA TTAAGGGGGA ATTGCTACCA CATCTTACAG AGAGTTATAG AAAATCAAAA 240

TTTAAGGAGT AA 252

(2) INFORMATION FOR SEQ ID NO: 280:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 840 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature (B) LOCATION 1...840

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 280:

ATGAGAGTAA TAATAAAGTT TATGCTGATT TCATTAAAAA CATTCCTAAA AATATTATTG 60

AAAATATTCC TAAAAACCTT CCAAAAGATT TGGATAGTTT GCGTGGTTAT TTGGGGGTTG 120

GGCTGTAGTT TTTTAAACGC TAACAGCGTT CAATTAGAAG AAACGCTGAG ACGAAATCCT 180

AAAAATCTTA TTTGGCAACA CTTTAAAAAG AAGTTTAAAA AGAGTAACAC GATCCCTTAT 240

GCCCCTAATA GCCGTTGGAA ATATTTAGGC ACAAGTATAG GGATTTTGGG CGTGTCGTTG 300

GTGATAGGGA TTGTGGGGTT GTATCTCATG CCAGAGAGCG TAACGAATTG GGATAAAGAA 360

AAGTTTGGCG TCAAAAGTTG GTTTGAAAAT GTCCGCATGG GGCCAAAACT AGACAATGAT 420

AGTTTTATTT TTAATGAAAT CTTGCACCCT TATTTTGGGG CTATGTATTA CATGCAACCG 480

CGCATGGCTG GGTTTAGCTG GATGACATCA GCGTTTTTTT CTTTTATCAC TTCTACGCTT 540

TTTTGGGAAT ATGGCTTGGA AGCGTTTGTG GAAGTGCCTA GCTGGCAGGA TTTGGTGATC 600

ACGCCCTTAC TAGGTTCCAT TTTAGGGGAA GGGTTTTACC AGCTCACGCG CTATATCCAA 660

CGCAACGAAG GCAAGCTGTT TGGCTCTTTA TTTTTAGGGC GTTTAGCCAT CGCCCTTATG 720

GATCCTATCG GTTTTATCAT TAGGGATTTA GGGCTTGGGG AAGCCTTAGG GATTTATAAT 780

AAACATGAAA TCCGTTCTAA TTTAAGCCCC AATGGTTTGA ATTTGACTTA CAAATTTTAA 840

(2) INFORMATION FOR SEQ ID NO: 281:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 531 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...531

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 281:

ATGAAACTTT TTAACCCTCG TTTAATCGTT TTTATATTCG CGCTTCTTTT AGGGGTAGGG 60

TTTTCTGTGC CTTCTTTGCT AGAAACTAAA GGCCCTAAAA TCACTTTAGG TTTGGATTTA 120

AGGGGGGGGT TGAACATGCT TTTAGGGGTG CAAACCGATG AGGCTTTAAA AAACAAGTAT 180

TTAAGCCTAG CGTCTGCTTT AGAATACAAC GCTAAAAAGC AAAATATCTT GCTTAAAGAC 240

ATTAAATCCA GTTTAGAGGG GATCAGTTTT GAGCTTTTAG ATGAAGATGA GGCGAAAAAA 300

TTAGACGCGC TTTTATTGGA ATTGCAAGGT CATAGCCAGT TTGAAATCAA AAAAGAAGCG 360

GAGTTTTATA GCGTGAAACT CACCCCTTTA GAGCAAGAGG AATTGCGTAA AAACACGATC 420

TTGCAAGTGA TAGGGATCAT TCGTAACCGC TTGGATCGAT TTGGCTTGGC AGAGCCTGTA 480

GTCATTCAGC AAGGCCGAGT AGAATTTCGG TGCAATTGCC CGGCATTAAG A 531

(2) INFORMATION FOR SEQ ID NO: 282:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1311 base pairs

(B) TYPE: nucleic acid (C) STRANDEDNESS : double

(D) TOPOLOGY- circular

(11) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE- NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...1311

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:282:

ATGATGAAAT TTTTTCTTTT AAAGAAATTC AGCGAATTTT TAAACACTCA AACGCATTTT 60

AACCTCAAAC GCTTGAACGC GTCTAGTTTT TTATTAGAGA CTTTTTCTAA AGAAAAACAC 120

GCCTTTGTTG TGGATTTGAG CGCGCCTTAT ATTGGTTTGT CCAAAAAACC CCCAGAGAGC 180

GTTTTAAAAA ACACTTTAGC GTTAGATTTT TGTTTGAATA AATTCACCAA AAACGCCAAA 240

ATTTTACAAG CAAACGTCAT TGATAACGAT CGGATTTTAG AAATCAAGGG CGCTAAAGAT 300

TTAGCTTATA AGAGTGAAAC TTTTATTTTG CGTTTAGAAA TGATCCCTAA AAAAGCCAAT 360

CTCATGATTT TAGATCAAGA AAAATGCGTG ATAGAGGCTT TTCGTTTTAA TGACAGGGTG 420

GCTAAAAACG ATATTTTAGG GGCATTGCCT CCTAATATTT ACGAGCATCA AGAAGAGGAT 480

TTGGATTTTA AGGGATTGTT GGACATTTTA GAAAAAGATT TTTTATCCTA TCAGCACAAA 540

GAATTGGAAC ACAAAAAAAA TCAAATCATC AAGCGATTAA ACGCCCAAAA AGAACGCTTG 600

AAAGAAAAAT TAGAAAAACT AGAAGATCCT AAAACTTTAC AGCTGGAAGC GAAAGAATTG 660

CAAACTCAAG CCTCATTGTT GCTCACTTAC CAGCATTTAA TCAACAGGCG TGAAAATCGC 720

GTGATTTTAA AGGATTTTGA AGATAAAGAA TGCATGATTG AAATTGATAA GAGCATGCCC 780

TTAAACGCTT TTATCAATAA AAAATTCACT CTCAGCAAGA AAAAGAAACA AAAATCGCAA 840

TTCTTGTATT TAGAAGAAGA GAATCTGAAA GAAAAAATCG CTTTTAAGGA AAATCAAATC 900

AACTATGTTA GAGACGCTGC AGAAGAAAGC GTTTTAGAAA TGTTTATGCC GGTAAAAAAC 960

TCTAAAATCA AACGCCCGAT GAACGGGTAT GAAGTGCTGT ATTATAAGGA TTTTAAAATC 1020

GGTTTAGGGA AAAACCAAAA AGAGAATATC AAGCTTTTAC AAGACGCAAG AGCGAATGAT 1080

TTGTGGATGC ATGTGAGAGA TATTCCTGGA TCGCATTTGA TCGTTTTTTG CCAAAAGAAT 1140

ACGCCTAAAG ATGAGGTCAT TATGGAATTA GCCAAAATGT TGATTAAAAT GCAAAAAGAT 1200

GCGTTTAATG GTTACGAGAT TGACTACACG CAACGAAAAT TTGTCAAAAT CATCAAAGGA 1260

GCTCATGTCA TTTACTCAAA ATACCGAACT ATTAGTCTAA AGGACACTTA A 1311

(2) INFORMATION FOR SEQ ID NO: 283:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 294 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori ( ix ) FEATURE :

(A) NAME/KEY: misc_feature

(B) LOCATION 1...294

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:283:

ATGGGACAAA CTAAAGAAAT TATAACGACG CTTTTACCCC TTTTGGTGTT GTTTCTTATT 60

TTTTATTTTT TGATCGTTCG CCCGCAACGC CAACAGCAAA AAAAGCATAA AGAAATGATA 120

GAGGGCTTGA CTAAGGGCGA TAAAATTGTC ACTCAAGGAG GGCTGATCGT TGAAGTGCTT 180

AAAGCGGAAG CGAATTTTTT TAGCGTGAAA CTCAATGATG ACACCACCGC TAAACTTTCT 240

AAAAACTATG TAGCGTTCAA ATTAGACGAA GAAACAACAC CCAACAACAA CTAA 294

(2) INFORMATION FOR SEQ ID NO: 284:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 621 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...621

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 284:

TTGAAGTTTC AAATTGTGAG TTTGTTATTG GCTTTTTTAT TAGCCTCTTG TTTGCCCCCT 60

AAGGGCCATC ATTCTGGTTT GGTGAATATG TATATTGCGC ATCAAGGCCA GAGCGTACGC 120

ACTTATTGGC GCAAAGTGGA TAGAGGAGTT GTCGCCAAAC ACAATGAAAC GCTTAAAGAA 180

AACCCCAAAA TAAAGCTCAA AGACCCTAAG GGGCCTTTGT TCATGCTAGG GAGCAATCGT 240

TTCATGCTTT TATGGAAAAA CCGCTATACT TTAGCTAAAG TCCAATCGTT CAAGCTAGAG 300

CCTGGGTTTT ATTACTTGGA TTCTTTTAGC GTGGAAACTC AAAAAGGCAT CTTGCAAAGC 360

GCTCCTGGCT ATTCATACAC CAAAAATGGC TACGATTTTA AGAACAACCG CCCCTTTTTC 420

CTAGCCTTTG AAGTCAAACC TGACAGCAAG ATCGTTCTCC CTAGCGTGGA ATTGAGCTTG 480

ATTAAAACCC CTAGAGGCTT TTTAGGGGTG TTTTTATTTG ACAACAACGA AAAGGGGGCT 540

AATACCCCAT GGATTGAGGG GAGCTTGAAT TTAAAGCTTA AAAACGCTTC TTTTAAAGAC 600

GCATGGGAGT TGGAACGATA A 621

(2) INFORMATION FOR SEQ ID NO: 285:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1599 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (m) HYPOTHETICAL: NO

(iv) ANTI-SENSE. NO

(vi ) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...1599

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 285:

ATGAGAAAGG TTATCATAAT GAATGGTTAT TTGAGGGTAA AAACCCCGTA TTTTTTAGCG 60

TCGGTCGTTT TGACTTTTTG GACTTTTAAT TCTTTTATGA GCGCGAAAGA TAAGCACCAT 120

TTTTTAAAAA AAGTTACAAC CACCGAGCAA AAATTCAGTT CTAGTGCCCC AATTTCATGG 180

CAAAGCGAAG AGGTGCGTAA TTCCACAAGC TCTCGCACGG TGATTTCCAA CAAAGAACTC 240

AAAAAAACGG GGAATTTGAA TATTGAAAAC GCCTTGCAAA ATGTGCCAGG GATTCAAATC 300

AGAGACGCTA CAGGCACGGG CGTGCTGCCT AAAATTTCGG TGCGCGGTTT TGGTGGGGGC 360

GGTAACGGGC ATAGCAACAC CAACATGATT TTAGTCAATG GTATCCCCAT TTATGGCGCG 420

CCGTATTCCA ATATTGAACT GGCGATTTTC CCTGTAACTT TCCAGTCAGT GGATAGGATT 480

GATGTGATTA AGGGGGGAAC GAGCGTCCAA TACGGCCCTA ACACTTTTGG AGGCGTGGTG 540

AATGTCATCA CTAAAGAAAT CCCCAAAGAG TGGGAAAATC AAGCGGCTGA AAGGATCACT 600

TTTTGGGGGC GCTCCTCTAA TGGGAATTTT GTCGATCCCA AAGAAAAAGG CAAGCCCTTA 660

GCCCAAACTT TAGGAAACCA AATGCTGTTT AACACTTATG GGCGAACGGC TGGGATGTTG 720

GGTAAATATA TAGGCATTAG CGCTCAAGGC AATTGGATTA ATGGGCAAGG TTTCAGGCAA 780

AATAGCCCTA CAAAGGTGCA AAACTACTTG TTGGATGCGA TTTATAAGAT CAATGCGACC 840

AATACTTTTA AAGCTTATTA CCAGTATTAT CAATACAACT CTTACCATCC AGGCACTTTG 900

AGCGCGCAAG ATTACGCCTA TAACCGCTTC ATCAATGAGC GCCCTGACAA TCAAGATGGA 960

GGGCGAGCCA AGCGCTTTGG GATCGTGTAT CAAAACTACT TTGGCGATCC GGATAGGAAA 1020

GTGGGGGGCG ATTTTAAATT CACTTATTTC ACGCATGACA TGAGTAGGGA TTTTGGGTTT 1080

TCCAACCAAT ACCAAAGCGT GTATATGAGC GGTCAAAATA AGATTTTACC CTTTAAAGGC 1140

AAGGGAGAAA TCAGCGCAAA AAACCCTAAT TGCGGTCTGT ATTCTTATAG CGACACGAAT 1200

AGCCCTTGCT GGCAATTTTT TGACAATATC CGCCGATCCG TGGTGAATGC CTTTGAGCCA 1260

AAACTCAATC TTATCGTCAA TACTGGTAAA GTCAAACAAA CTTTTAACAT GGGAATGCGC 1320

TTTTTAACTG AAGATTTATA CCGCCGATCC ACCACCAGGA AAAACCCTAG CATGCCTAAT 1380

AATGGGAGTG GGTTTGATGC AGGAACTTCA CTCAATAATT TCAACAATTA TACCGCTGTG 1440

TATGCCAGCG ATGAAATCAA TTTCAATAAC GGCATGCTAA CGATCACGCC GGGCTTGAGA 1500

TACACTTTTT TAAATTACGA AAAAAAAGAC GCTCCTCCCT TTAAGGTGGG TCAAACCCCA 1560

AAAACCACGA AAGAGCGTTA TAACCAATGG AATCCGGCA 1599

(2) INFORMATION FOR SEQ ID NO: 286:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 768 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE: ( A ) ORGANISM : Hel icobacter pylori

( ix ) FEATURE :

(A) NAME/KEY: misc_feature

(B) LOCATION 1...768

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 286:

ATGAAAAAGA TTTTTTTAGG TATGGCATTA GCCTTTAGTG TGTCCATGGC AGAAAAAAGC 60

GGCGCGTTTT TAGGAGGGGG GTTTCAATAT TCTAATTTAG AAAACCAAAA CACCACCCGC 120

ACCCCAAGCG CTAACAATAA CACCCCGATA AACACTTCAA TGTTTGGCAA CAATCAAGCG 180

GCTCCAGCCC AAGAAACGCC AAGCGTGATC AACACCAATA ATTACGGGCA AATGTATGGG 240

GTAGATGCGA TGGCAGGGTA TAAGTGGTTC TTTGGCAAAA CCAAACGCTT TGGCTTTAGG 300

ACTTATGGAT ACTACAGCTA TAACCATGCG AATTTGAGCT TTGTAGGCAG TAAGCTTGGA 360

ATCATGGATG GCGCATCTCA AGTGAATAAC TTCACTTATG GCGTGGGCTT TGATGCGCTC 420

TATAACTTCT ATGAAAGCAA AGAGGGCTAT AACACAGCAG GGTTGTTCGT GGGCTTTGGA 480

TTAGGAGGGG ATTCGTTTAT CGTTCAAGGA GAGAGCTACT TGAAATCTCA GATGCAAATT 540

TGCAACAACA CCGCCGGCTG TTCAGCGAGC ATGAACACGA GCTACTTCCA AATGCCTGTG 600

GAATTTGGTT TTAGGAGCAA TTTCTCTAAA CACAGCGGGA TTGAAGTGGG CTTTAAATTG 660

CCTTTATTTA CCAACCAATT CTATAAAGAA AGGGGCGTAG ATGGATCGGT AGATGTGTTC 720

TATAAAAGGA ATTTCTCTAT CTATTTTAAC TACATGATCA ACCTCTAA 768

(2) INFORMATION FOR SEQ ID NO: 287:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1002 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1002

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 287:

ATGCTAATCG CTCGCTTTAA AAAAGCTTTA ATTTCCTATT CTTTAGGGGT TCTTCTTGTT 60

TCATCGTTAT TAGGCGTGGC TAACGCTTCT AATCAAGAGA TCCAAGTCAA GGATTATTTT 120

GGGGAGCAAA CCATAAAGCT TCCTGTTTCT AAAATAATCT ACTTGGGCAG CTTTGCAGAA 180

GTGCCTGCCA TGTTCAATAC TTGGGATAGG GTCGTGGGCA TTTCGGATTA CGCTTTTAAA 240

TCTGATATTG TTAAAGCCAC TCTCAAAGAT CCTGAACGCA TTAAACCCAT GAGCAGTGAT 300

CATGTGGCGG CGTTGAATGT GGAATTATTA AAAAAGCTTA GCCCTGATCT TGTGGTAACC 360

TTTGTGGGTA ACCCTAAAGC GGTAGAGCAT GCGAAAAAAT TTGGGATTTC ATTCCTTTCT 420

TTCCAAGAAA AAACCATTGT AGAGGTCATG GAAGATATTG ACGCTCAAGC TAAGGCCTTA 480

GAAGTTGACG CTTCTAAAAA ATTGGCTAAA ATGCAAGAAA CTTTGGATTT TATCAAAGAG 540

CGTTTGAAAA ATGTCAAAAA GAAAAAGGGG GTGGAGCTTT TCCATAAAGC CAATAAAATC 600

AGCGGCCATC AAGCCCTTGA TTCAGATATT TTAGAAAAAG GGGGCATAGA CAATTTTGGC 660

TTGAAATACG TCAAGTTTGG GCGCGCTGAC ATTAGTGTGG AAAAAATCGT TAAAGAAAAC 720 CCTGAGATTA TTTTTATTTG GTGGATAAGC CCGCTTAGCC CTGAAGACGT GTTGAACAAC 780

CCTAAATTTT CCACTATCAA AGCCATTAAA AACAAGCAAG TCTATAAGCT CCCCACAATG 840

GATATTGGCG GACCTAGAGC CCCACTCATT AGTCTTTTTA TCGCTTTAAA AGCCCACCCT 900

GAAGCGTTT AGGGCGTGGA TATTAATGCG ATAATCAAAG ATTACTATAA AGTGGTCTTT 960

GATTTGAATG ACGCGGAAGT TGAACCCTTT TTGTGGCACT GA 1002

(2) INFORMATION FOR SEQ ID NO: 288:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 165 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...165

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 288:

ATGAAAAAGC AAATCTTGAC AGGTGTTTTG TTATCAGTTT TGGCAGTGAG TTCTGCATAC 60 GCTCACAAAG ATAAAAAAGA CGCTAAAAAA CCTGAGTTAA GCTCTCAATT AGTGGCTCAC 120 AAAGATAAAA AAGACGCCAA AAAACCTAAA AACTCAGTGG CCTAA 165

(2) INFORMATION FOR SEQ ID NO: 289:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 429 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...429

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:289: ATGTATAAAT TAGGAATATT TTTATTAGCC ACCTTACTAT CAGCTAACAC GCAAAAAGTG 60 AGCGATATTG CTAAAGACAT CCAACATAAA GAAACCCTTT TGAAAAAAAC CCATGAAGAA 120

AAAAACCAAC TGAACAGTCG TTTGAGTTCT TTAGGCGAAG CGATCCGCTC TAAAGAGCTT 180

CAAAAGGTTG AGATTGAACG CCAAATGGTC GCCTTAAAAA AGAGTCTTGA AAAAAATCGT 240

AACGAAAGTT TGGTGCAAGA AAAAGTCCTA ACCAACTACC GCAAGTCTTT AGATCATTTG 300

CAAAAACAAC GATCGTTTTT ACAAAAGAGA GTGTTTGATA CGCTTTTAGA GGATTTTCTT 360

TTCTCACAAG CCCTAAAGGG GCAGAATTTA GCCTCTTCTA ATGATGTGAT TTTGCTAAGT 420

GGCGTTTGA 429

(2) INFORMATION FOR SEQ ID NO: 290:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 594 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...594

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:290:

ATGGATAAAA ACAACAATAA TAATCTCCGC TTGATTTTAG CGATCGCTCT GTCTTTCTTG 60

TTTATCGCTC TTTATAGCTA TTTTTTCCAA GAACCAAACA AAACAACAAC CGAAACCACA 120

AAGCAAGAAA CAACCAACAA CCACACAGCA ACAAGCCCCA CCGCGTCCAA TACCATCACC 180

CAAGATTTTA GCGTTACCCA AACCATCCCT CAAGAGAGTT TGTTAAGCAC GATTTCTTTT 240

GAACATGCCA AAATTGAAAT TGATTCTTTA GGGCGCATCA AACAGGTTTA TCTCAAAGAT 300

AAAAAGTATC TAACCCCTAA AGAAAAGGGC TTTTTAGAGC ATGTGAGCCA TCTTTTTAGC 360

TCCAAAGAAA ACTCGCAACC CTCCCTAAAA GAGCTCCCCC TTTTAGCAGC CGATAAACTC 420

AAGCCTTTAG AAGTGCGTTT TTTAGACCCC ACGCTCAATA ATAAAGCGTT CAACACCCCT 480

TATAGCGCCT CAAAAACCAC CCTTGGGCCT AACGAACAGC TCGTTTTAAC CCAAGATTTA 540

GGCACTCTTA GCATCATTAA AACCCTGACT TTTTATGATG ATTTGCATTA TTGA 594

(2) INFORMATION FOR SEQ ID NO: 291:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 780 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE: (A) ORGANISM Helicobacter pylori

(ix) FEATURE

(A) NAME/KEY mιsc_feature

(B) LOCATION 1 . 780

(xi) SEQUENCE DESCRIPTION. SEQ ID NO.291

ATGGCGTGTT GGCATAAAAG ATTGGCAGTT GGTTGTTGTA TCGTTTTATT GTCATGCGTA 60

ATGAGTGCTA ATAATGTTAG TATCGTTAGA GACGATCCGC CCCTTGATCC AACGCTCCCT 120

GCATGGATTT ATTCTGTTGC GTTATTGAAA GTGTATTTTA GCGATGGGAC TTATAAAGAA 180

GGCTATGCGA CTTTGCTAGA AAACGGGCGT TATATCGCTT CTTCTGAAAC GCTCTATTCT 240

AATGGCTTGT ATCCTAAAAT GATTTTAGCC AAAATGCAAG ACAGCAGTGC TAAAGAGCTG 300

ATTTGCATAG CCAGCTTGCA CCTTGAAGCG ATGGATAGGG ATCAAGGGCT TTCGCTCTTA 360

AAAACCGCCG ATTTTAGAGA CGATTATTGT CATAAAAGAG AAGAGAGCTA TTATCATGCA 420

AGGATTTATG CCAAATACGC TCAAACTTTC CATTCAAATC CTTATACCAA TCAAAAAACA 480

CCCACTTCCG ATCTCTACTA CCCGGCGTTA AATGAGGGGA ATTCTTTTTC CATACAGACA 540

ACGGACATTT CTGTGGCTGA ACTTTTGAAA TCTAAAAAGT TTCTTTCGCT TGATGCTTCT 600

TTTAAAAAGG GGAGCGTGTT GTGGGGAGGG AGGCCTTATT TTAGCGAGGT AGGGGAGTTT 660

ATGGGAATGG CTAGCAGCAC TTTAGAAAAC CAAGAAAGTT TGGTGATTAT CCCTAAAGAA 720

AAGATTGCGC GATTTTTAAG CGCTCTAAAA AATCAAAATA TTTTTCCAAA CATTCCCTAA 780

(2) INFORMATION FOR SEQ ID NO: 292:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2007 base pairs

(B) TYPE- nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE.

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...2007

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:292.

ATGAAAAATC AACACAAAAA TCCCCTAACA AAAGCTTTAA TGAAAACTTA TCCATATAAC 60

CATTTTTTAT TTTTCTGCTT TATTCTAGGA GCGTTTTTAT TAGGTTTGCT CAGTCCAGCT 120

TATGCTTTAA GTATTATCAC CACTAAAGAA ATTGACGCTA ATTTGCTTAA TGGAGCGATA 180

GAAAGCAGGG TGGTGTTAGG CAAGAGGGTG TTTAAAGTAG AAGCTCATGG GTTTTATTTT 240

AGAAACAATG CGACTAACAG CATAGATATA GAAATCACCA GTCTTTTAAG AGACAATCAA 300

TCGTTTCCTT TGACTAGCAG TGCTAAAACC AGTTTAAAAA TACCTCCTAA CGCCAAGATT 360

AAAAAATCCA CTATCCTTGT TTTGAAAGGC GAGAACGCTG AAGAAGTGGC TAAGATTTTA 420

GGCGTTAGCA AAGAAGAATA CCAAAAGCTA GAAAACATCG CTCAAACCAA AGCGGCTAAT 480

GACCCTATGT ATGCTAACAC GCCTTTTAGT AATGGTTCTG ATAGTTCCTT TTACGATAAC 540

AATCCTAATA GCCCTAGCAA TAACGCTATC AATGGCAAAG ATGGCGCAAA TGGGAGTAAC 600

GGCTATGGGG CAAATGGCAA TGATGGGGTA AATGGGATCA GTGGGAGTAA TGGTGCAAAT 660

GGGAGTCATT CAAATAATAA TGCAATAGGC AGTGGTATTG ATACAGATGG CGTGTTAGGG 720 GTGGATGGGG TGAATGGCTC TAGTTCTTCA AGTGGCGGCT CTGTAGGGGG TTATGAGAAT 780

AATTTCACTA ATCATGGCTC TACTAACAAT AACACAGGAG GGTATGACAA TTTTAATAAT 840

GGCAGCTCAA GTGGTGGGAG TTTAGGGAAT GGGGGGCTTT TCCCTATTCC TTTTGGTAAT 900

GGAGACACAA ACAATTCCAA TAATTCCACT AACACCACTA GCCCAACTAA TGGCAGTAGT 960

TCTAATAACG CCACTAATCC TAGTTCGCAA GAAAACAATT ACTCCAGCCA GTATTGTAAA 1020

GTGCCAGAGT TAAGCCCCAA CAACACGATG AAACTAGATG TTATCGCTAA AGATGGCTCT 1080

TGTATTTCTA TGAACGCTTT AAGAGATGAC ACTAAATGCG CTTATAGATA CGATTTTGAA 1140

GCCGGTAAAG CCATCAAGCA AACGCAATAC TACTATGTAG ATAGGGAAAA TAAAACGCAA 1200

AATATCGGTG GTTGTGTGGA TTTACAAGGC GCTCAATACG CCATGCAACT TTACAAAGAT 1260

GACAGCAAAT GCGCCTTACA AACCACGAGC GATAAAGGTT ATGGTATGGG GAAAACGCAA 1320

ACCTTTCAAA CTGAAATCGT GTTTCGTGGG ATGGACAATT TAATCCATGT CGCTGTGCCT 1380

TGCAGCGATT ATGCAAGGGT GCAAGACAGG ATTGTTAGGT ATGAAAAAAA TGATAAAACC 1440

CAAACCTTAA CGCCTATAGT GGATCAGTAT TATAATGATC CTAACAACCC TAACAAGCAA 1500

GAGATTTTAA ATCGTGGGAT TGCCACCCAA TTAAGCTCGC AATATCAAGA ATTTGCATGC 1560

GGTCAATGGG AATACAATGA CGCTAAATTA GAAGCCAAAA GACCTACAAT GCTAAAAAGC 1620

TATAACAAGC TTAATGGAGA ATGGGTAGAA GTTACGCCCT GTAATTTTGA AGCAGGGATT 1680

AAAAGCGGTG CGGTTGTTAG CCCTTATGTG ATGGGCGTGC CTAGTTCTAA AGTCTTAAGC 1740

GATATTACTA CAAGCCATTA TTTTAGGATA GAAAGGAAAA ATTATGGTGA GAGAGAACAA 1800

TGCCAAAAAC TTTATGGAGT CAATCGTTGC CAACCGCAAT ATTCCATACT GATCCTAGTA 1860

TCACCGATTG GAGCGCCACT TACAAAACCA CTACCACCCA AACCACTCAA CCTTATTTAC 1920

GCCCAGCCCA AGATAATGAA AAACACCCCA CAACCTATAA TCTTATCACC ACTCAAACCA 1980

CCATCAACAG GACTCAAAGC GTTTTGA 2007

(2) INFORMATION FOR SEQ ID NO: 293:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 987 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...987

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 293:

ATGACTTATA AAGAACGACT CATACACGAA AAAATATTAA ACCAAAACGA CAAGGGTTTT 60

AAAACAGAAC TGCGCATTTT GAGCGTTTTT ATCGTGGAAT TTTTGGTGAA TATTCTAGGG 120

TTTATGTTGG CTAAAATGCC TCATTTTTGG TTTTTAAGGT GCGTTAAAGC TTTAGCGTGG 180

CTCATGAAAA CTTTTGATAG GCGCCGTTAT TTTGACGCTA AGGCCAATTT GGATTTTGTG 240

TTTGGGGATT CTAAAAGCGA AGAAGAAAAA AAAAGGATCA TTAAAAAGGG GTATGAAAAT 300

TTTGCTTTCA TTATTTTAGA AACCATTAGA GTGATCTTTA TCCCTAAAGA TGAATACGAC 360

GCTCGTTTCA CGCTCATCAA TGAAGAAAAC GTGTGGAAGT CCTTAAACAA GGAAGGCCAA 420

GCGATCACTT TGTGCATGCA TTTTGGCTAT TGGGAAGCGG TAGGCACGAC TTTGGCGCAA 480

TATTATGAAA ATTATGGTAG GGGGTGTTTG GGGCGTTTGA CTAAATTCGC TCCCATCAAT 540

CACATGATCA TGAGTAGGCG AGAGGCGTTT GGGGTGCGTT TTGTCAATAA AATAGGGGCG 600

ATGAAAGAAC TCATTAAAAT GTATAATCAA GGCAATGGCC TGGTGGGGAT TTTAGTGGAT 660 CAAAATGTCG TGCCTAAAGA CGGGGTGGTG GTGAAATTTT TCAATAAAGA CGCTACGACC 720

ACCACGATCG CTTCTATTTT GTCGCGCCGT TACAATATAG ACATTCAGCC GGTATTCATT 780

GATTTTAACG ATGATTATTC GCATTACACA GCGACTTATT ACCCAAGTAT CCGCTCTCAA 840

ATCACTGATA ACGCGCAAAA CGATATTTTA GAATGCACGC AAGCCCAAGC GAGTTTGTGC 900

GAAGAGGTGA TTAGAAACCA CCCGGAAAGT TATTTTTGGT TCCACAGGCG TTTTAAAAGC 960

ACCCACCCTG AGATTTATCA AAGATAG 987

(2) INFORMATION FOR SEQ ID NO: 294:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 417 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...417

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 294:

ATGTTATATC TAAGGAAAGA AAATGGGGTT AGGACACTAA TAAGTTTAGG GATTTTGTTA 60

AGCGTTTTGA ATGGCGATGA TCTGAGATTG TATTCAAAAC CTTTGGTCTA TTCGGCTGGA 120

AGTGGGATTA TTGGGATTGA TATTGACAAA CGGACATTCT ATAAACGAGC GTTCGCTTTC 180

ACGATGAAAT CGTTGTTTGG TGAAAACTTG CTTTTGTTTG TTAAATTGAA GCATTCTGCG 240

TTGATGAGCA AACACATGAA AGGGCCTTTA GAAAACCGCC ACCACCATTC TTTCGCTAAA 300

AATTATGAAA AAGCGGTTAA TGGTTGTCAA AAATATGTCC ATATCAAATT GCCTGAAGGC 360

GCTCCTAGCA ACTTCCAATC AGGCTCATAC ATGGCGACTA TGGTGATGCG TTTTTAA 417

(2) INFORMATION FOR SEQ ID NO: 295:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 987 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature (B) LOCATION 1...987

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 295:

ATGCGTAAGG TTTTATACGC TCTCATGGGC TTTTTGTTGG TTTTTAGTGC TTTAAAAGCC 60

GATGATTTTT TAGAAGAAGC GAACGAAACA GCCCCAGCGA ATTTAAACCA CCCCATGCAG 120

GATTTAAACG CCATTCAAGG GAGCTTTTTT GACAAAAACC GCTCCAAAAT GTCCAACACT 180

TTGAACATTG ATTACTTTCA AGGGCAAACT TATAAAATCC GCTTGCGTTA TGCGATGGCG 240

ACTTTATTGT TTTTTTCAAA ACCCATTAGC GATTTTGTTT TGGGGGATAA GGTGGGTTTT 300

GATGCGAAAA TTTTAGAAAG CAATGATCGC ATTTTACTCA TCAAACCCTT ACAAATCGGC 360

GTGGATTCTA ATATCAGCGT GATTGATAGC GAGGGTAAGA TTTTTTCTTT CTATGTGTTT 420

TCTACCACTT TCACCAGCTC CAAACACCCT AATTTACAGG TTTTTATAGA AGATAAAAAC 480

TATTACACTA ACGCTTTTAT CAAGCCCCAA AAAGAAAATC AAGAAAATAT GTCTGAAAAT 540

GCCCCTAAAG ATGCCCAAAA AAATAATAAG CCCCTAAAAG AAGAAAAAGA AGAAACTAAA 600

GAAAAAGAAG AAGAGACTAT AATTATTGGC GATAACACCA ACGCGATGAA AATTATTAAA 660

AAAGACATCC AAAAAGGCTA TAAGGCTTTA AAAAGCTCTC AAAGGAAATG GTATTGTTTA 720

TGGGCTTGTT CTAAAAAATC CAAACTCTCC TTAATGCCTA AAGAAATCTT TAACGACAAG 780

CAATTCACTT ATTTCAAATT TGACAAAAGA TTAGCACTCT CTAAATTCCC GGTGATTTAT 840

AAGGTCGTTG ATGGTTATGA TAATCCGGTG AATACAAGGA TTGTGGGCGA TTACATTATC 900

GCTGAAGACG TTTCTACTAA ATGGACTTTA AGGTTGGGTA AGGATTATCT GTGTATCCGT 960

TTTGTCAAAA GGCGCAAAGG TGAATAA 987

(2) INFORMATION FOR SEQ ID NO: 296:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1008 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1008

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:296:

GTGATGTTTC ACAAAGCCCT TATTACCTTT ATCGTTCTAT GGTTTTTTTT GAATGGCTTA 60

GGGGCTTATG ATTTCAAGCA TTGTCAGGCT TTTTTTAAAA AAGCGAGCCT TCAAAAAGGG 120

GGCGTGGCTT TAAAGGAATT GCCTAAGGGC GTGTATTTGT ATTATTCTAA AACCTACCCC 180

AAACACGCTA AAGTCATCAA ATCCGATCCT TTTATAGGGC TGTATTTGTT GCAAAGCGCG 240

CCAAGCGAGT ATGTTTATAC ATTAAGGGAT TTAGACAAAG ACGCCCTTAT AAGACCCATG 300

GCCAGTATAG GGGCTAATCA AGCCACAGAA GCGCGATTAT TGGTAGGGCA AAAAGGCTAT 360

GACCGCTACG CTCAAATTTC ACAAAAAACC CAAAAAAATG GCGTTATCAG CAATATTTGT 420

TATCAAATGC TAGGGCTAGG GGTAGGGGGG AACGGCTTTA TAGAAACGAA ATTCATCAAG 480

CGCTTTTTAA ACCAACAAGA GCCTTATTAT GGGGATATTG GGGTGCGTTT AGAAGAACGT 540

CATAAGCGTT TGGTGGTAGC GCAATTTGAT CCCTTTTTCC CTAAAAACCC TTTTTTAAAA 600

AACGATGAAA TCCTAGCGAT CAATGATTAC AAGATCCACT CGTTAGCGGA GTTTGAATGG 660

GTGGTGAGCA ATCTTTCATA CCAAAGCCTC GCCAAAGTGA AAATCAAACG AAACCATCAA 720 ATCAAAGAAG TAACGCTCAA AGTCAATAAA CGCTATGGGG GGTTTTTGCT CAAAGACACT 780

TTTTTAGAGC GCTATGGCAT CGCTTTAGAC GAGCGTTTTA TCATCACTAA AATAGGCGCT 840

CATTTGCCCA AAGGCTTGGA TTTTTTAAAG CTTGGGGATA GGATTTTATG GGTGAATCAT 900

AGAAGCGTTT CGTTCAACCC GAAAGCTTTA AGAGAAGCGT TAAGCACGCC TAAAATTGAA 960

TTATTAGTCT GGCGTCAAGG CTTTGAATTT TACATTAAAG TCCGTTGA 1008

(2) INFORMATION FOR SEQ ID NO.297-

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 753 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY- circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi ) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...753

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 297:

ATGCTAGGAA GCGTTAAAAA AACCCTTTTT GGGGTCTTGT GTTTGGGCGC GTTGTGTTTG 60

AGAGGGTTAA TGGCAGAGCC AGACGCTAAA GAACTTGTTA GTTTAGGTAT AGAGAGCGTG 120

AAGAAACAAG ATTTCGCTCA AGCTAAAGCG CATTTTGAAA AAGCGTGTGA GTTAAAAGAA 180

GGTTTTGGGT GTGTTTTTTT AGGGGCGTTT TATGAAGAAG GGAAAGGAGT GGGAAAAGAC 240

TTGAAAAAAG CCATTCAATT TTACACTAAA GGTTGTGAAT TAAATGATGG TTATGGGTGT 300

CGCCTACTAG GAAATTTATA CTATAACGGA CAAGGCGTTT CTAAAGACGC CAAAAAAGCC 360

TCACAATATT ACTCTAAATC TTGTGAATTG AACCATGCTG AAGGGTGTAC GGTCTTAGGA 420

AGCCTACACC ATTATGGCGT AGGCACGCCT AAGGATTTAA GAAAGGCTCT TGATTTGTAT 480

GAAAAAGCTT GCGATTTAAA AGACAGCCCT GGGTGTATTA ATGCAGGATA CATGTATGGT 540

GTGGCAAAGA ATTTTAAGGA GGCTATCGTT CGTTATTCTA AAGCATGCGA ATTAAAAGAT 600

GGTAGGGGGT GCTATAATTT AGGGGTTATG CAATACAACG CCCAAGGCAC AGCAAAGGAC 660

GAAAAGCAAG CGGTAGAAAA CTTTAAAAAA GGCTGCAAAT CAAGCGTTAA AGAAGCATGC 720

GACGCTCTCA AGGAATTAAA AATAGAGCTT TAG 753

(2) INFORMATION FOR SEQ ID NO: 298:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 372 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (ill) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc__feature

(B) LOCATION 1...372

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 298:

ATGCGTTTAT TGATCGCGCT AGTTTTGTTC TTATGGTGGT TAAATTTAGG CGCTAAAGAA 60

GCGGATTTCA TCTCTGATTG GGAATACGGA CTGGCCCTTT ATAAAAACCC TAGGGGTGTT 120

GCGTGCGCAA AATGCCATGG CATTAAAGGC GAACAACAAG AAATCACCTT TTATTATGAA 180

AAAGGCGAAA AAAAAATCCT TTACGCCCCT AAAATCAACC ATTTGGATTT TAAAACCTTT 240

AAAGACGCCT TGAGTTTGGG CAAAGGCATG ATGCCTAAAT ACAACCTGAA TTTAGAAGAA 300

ATCCAAGCGA TTTACCTTTA CATCACCTCT TTAGGGCATA AAGACGAGCG TAAGGATCCT 360

TCCAAGCCTT AA 372

(2) INFORMATION FOR SEQ ID NO: 299:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 543 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...543

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 299:

ATGTTAAACA AGTTTAAAAA AATCGTTGGC GTGGGTGTGT TAGTGGGCTG TTTAGGGGTT 60

TTGCAAGCTA AAAACAGCTT ATTTGTCTTA CCTTATGAGC AAAGAGACGC TCTCAATTCT 120

TTAATTTCTG GGATTAGCAG CGCTAGAGAG AACGTGAAAA TCGCTATTTA TAGTTTCACG 180

CACAGAGATA TTGCAAGAGC GATTAAAAGC GTAGCGAGTA GGGGGATTAA GGTGCAAATC 240

ATTTATGATT ATGAAAGCAA TCACAATAAC AAGCAATCCA CTATTGGCTA TTTAGACAAA 300

TACCCTAACA CGAAAGTGTG CTTATTAAAG GGGCTTAAGG CTAAAAACGG GAATTATTAC 360

GGCATCATGC ACCAAAAAGT AGCGATCATT GATGATAAAA TCGTGTTTTT AGGCTCAGCG 420

AATTGGAGCA AAAACGCTTT TGAAAACAAT TATGAAGTGC TTCTAAAAAC CGATGACACA 480

GAGACGATCC TCAAAGCCAA GAGTTATTAT CAAAAGATGC TAGAAGGTTG CGTTGGGTTT 540

TAA 543

(2) INFORMATION FOR SEQ ID NO: 300:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 423 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double (D) TOPOLOGY, circular

(11) MOLECULE TYPE- DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE- NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY- mιsc_feature

(B) LOCATION 1...423

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 300:

ATGAGAAGGA GTTTGGCTTT TTGCCTTTTA GCTTTGCTTG GATTACAGGT TTTAGGTGCT 60

AGAGACTTTT CGCAACTCAA AAACGAAGAA CTTTTAAAAT TAGCAGGAAC TCTGCCTTCT 120

AATGAAGCGA TTGATTATCG CATGGAAGTG TCTAAACGCC TTAAAGCCTT AAGTGCTGAA 180

GACGCTAAGA AATTCCGCGC GAATTTCAGC CGGATCGCTA GGAAGAATCT TTCTAAAATG 240

AGCGAAGAGG ATTTCAAAAA AATGCGTGAA GAAGTGCGTA AAGAATTAGA AGAAAAAACC 300

AAAGGTCTAA GCGCTGAAGA AATCAAGGCA AAAGGACTTA ATGTGAGCGT TTGCAGCGGC 360

GATACGAGAA AAGTTTGGTG TAGGGCTGTT AAGAAAAAAG ACGAACATTG CTCTCCTAAG 420

TGA 423

(2) INFORMATION FOR SEQ ID NO: 301:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 459 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...459

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:301:

ATGAAAAAAG CGTTGAAAAT ACTTTCTGTT GGCGCGTTGC TATTTGTGGC TTTAAACGCC 60

AAAGATTTCA GCAAAACAAG CGATGAAGAT TTGGCTAAAA TGGCTGGCGT TGTCGCTCCG 120

CAGGATATTG TGGATTACAC AAAAGAGTTG AAAAAGCGCA TGGAAAAGAT GCCTGAAGAC 180

AAGAGAAAGG CGTTCCATAA ACAATTGCAT GAATACGCGA CTAAAAACAC AGACAAAATG 240

ACCGTGGCGG ATTTTGAAGC CCGCCAAAAA GCCATTAAAG AAGCGCTTAA AAAAGGCAAT 300

ATGGAAGACA TGGATGATGA TTTTGGGTTG AGATCATGCA AGCATGGGAA AAAGCACAAA 360

CACGATAAGC ATGGCAAGAA GCATGGCAAA AAACATGACA AAGATCATGA CGATAAAGAC 420

CATGACCACC ATGATGAAGA TCACAGCGAT AAGCACTAA 459 (2) INFORMATION FOR SEQ ID NO: 302

(l) SEQUENCE CHARACTERISTICS

(A) LENGTH- 423 base pairs

(B) TYPE- nucleic acid

(C) STRANDEDNESS double

(D) TOPOLOGY, circular

(ii) MOLECULE TYPE- DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...423

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:302:

ATGCTAAAAA AGTTATTGCT CATTTCACTA TTTTTAGGGT TTTTAAGAGC AGAGGGCGAA 60

CATTATGAAA TCATCGCTGA ACTTTCCAAG GCTTTTTTGA AAGCCAAAGA GGTTTTGACT 120

GCGATCAATA AAACCTGTAT TGAAACCGGG CATGATCGCA CTCAAATACG CCTTCAAAAC 180

GATTTTTTAG AGAATTTGTC TCAAACAGAG CAACAATTTG ATGATTATTT TGAAAAGGAT 240

TTTAAAAGCG TAGGGGTTTT AAAAACCTTG CTTAAAGACA TCCAATCCTT AGAAAAAACT 300

TCCAACAAGC TCGTATGCGT TGCCCCAAAA AACGCTAAAA ATTTTGAAAT ATTAGAGGGA 360

GCGATAACGC AAATCATAGG ATTAGAAGAG CAGATGAATC AATTTATCAA TGGCGCGAAA 420

TAA 423

(2) INFORMATION FOR SEQ ID NO: 303:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 201 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...201

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 303: TTGAGTGGGG AACTGAGATT GTCTTGGTGG TTAGTGGCTC GTTGCAAAAC ATTGTTCGTT 60 CTTTTTTGCG AAGGATCAGC GTTTTCTTCA TTATTGATTT CATCAATTTT ATTTTCGTTA 120 TTGATCAGAT CATTCACTTC TTTGGTGACT TTTTCATCTT CTTCTTCATG CTCAATCTTT 130 TTTATATCCT TATTAGGTTG A 201

(2) INFORMATION FOR SEQ ID NO: 304:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 270 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...270

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 304:

TTGGTGGTTA GTGGCTCGTT GCAAAACATT GTTCGTTCTT TTTTGCGAAG GATCAGCGTT 60

TTCTTCATTA TTGATTTCAT CAATTTTATT TTCGTTATTG ATCAGATCAT TCACTTCTTT 120

GGTGACTTTT TCATCTTCTT CTTCATGCTC AATCTTTTTT ATATCCTTAT TAGGTTGATT 180

GATTTGATTG TTTTGAGTGG TTTTAGTGTT GTTTTGGTGC GATTGGGAYG ATTTTTTAGG 240

CTCATCTTTG CATGCGCTCA ACACGCTTAA 270

(2) INFORMATION FOR SEQ ID NO: 305:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 357 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...357

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 305: ATGAAAAAAT CCCTTTGTTT GTCTTTCTTT CTGACCTTCT CTAACCCTCT TCAAGCCCTT 60 GTCATTGAGC TTTTAGAAGA GATTAAAACT TCGCCGCATA AAGGCACTTT TAAGGCTAAA 120

GTCCTTGATT CTAAAGAACC AAGACAAGTT TTAGGCGTTT ATAATATCTC CCCACACAAA 180

AAACTCACGC TCACTATCAC TCACATATCC ACGGCAATCG TCTATCAACC CCTTGATGAA 240

AAACTTTCTT TAGAAACGAC CTTAAGCCCT AACCGCCCTA CTATCCCTAG AAACACCCAA 300

ATCGTTTTTT CTTCAAAAGA ATTGAAAGAA CCGCACTCAA ACCCAATACC TTCTTAA 357

(2) INFORMATION FOR SEQ ID NO: 306:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 738 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...738

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 306:

TTGAAAGCGT TTCAAACTTT TGGCGTGTTT GGGACAAGCG TGATCACTTG CATCACCGCT 60

CAAAACACAC AGGGCGTGCA TGGGGTGTAT CCATTGAGTG TAGAGAGCGT GAAAGCGCAA 120

ATCCTAGCTA TTAGAGATGA TTTTTCGATC AAGGCGTTCA AAATGGGGGC GTTATGCAAC 180

GCTCAAATCA TTGAATGCGT AGCGAACGCT TTAGAAACTT GTGATTTTGG GTTGTGCGTT 240

TTAGATCCGG TGATGGTGGC AAAGAATGGG GCTTTGCTTT TAGAAGAGGA GGCGATTTTA 300

AGCTTAAAAA AACGCCTTTT ACCTAAAACC AATTTACTAA CCCCTAACCT CCCTGAAGTC 360

TATGCGCTCA CAGGCGTTCA AGCGCGAGAC GATAAAAGCG CTTCAAAAGC GATGGGTGTT 420

TTAAGGGATT TAGGCGTTAA AAACGCTGTG ATTAAAGGGG GGCATACAGA ACATTTTCAA 480

GGGGAATTTA GCAACGATTG GGTGTTTTTA GAAGACGCTG AATTTACTTT AAGCGCCAAG 540

CGATTCAACA CCAAAAACAC GCATGGCACG GGTTGTACTT TGTCTAGCTT GATTGTGGGC 600

TTACTCGCTC AAGGGCTGGA TTTAAAAAAC GCTATCACAA AGGCTAAAGA GCTTTTAACT 660

ATCATCATTC AAAACCCCTT AAACATTGGG CATGGGCATG GGCCTTTGAA TTTGTGGAGC 720

ATCAAAAAGC ATGTTTGA 738

(2) INFORMATION FOR SEQ ID NO: 307:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 642 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE.

(A) ORGANISM. Helicobacter pylori

(ix) FEATURE.

(A) NAME/KEY mιsc_feature

(B) LOCATION 1...642

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 307:

GTGCTAGAAA AACAAGATAA AGACCTTTTT CTTTTGCAAG TGGGTAACAG GATTATCCCC 60

ACCAAAAGCG AACAGGAATT AAAAATCAAT CAGCCTTATT TTGCGACTAT GCAAAGAAAT 120

CAGCTGGGCG ACATTGTGCT TAAAAATTTA GTGCCTGCCC CAAAAATCTT AGACGCATTG 180

GACGATTTGC CCGTTATTGA AATGAAGAAA TTAAAAGAAA TATTGAGCGC CAAAGACAAC 240

ACCCCCCTAA AAGAATACAA AGAACTTTTG AGCGAAAAAT TAATCCATGC TAAAAGCTCG 300

CAAGAGTTTT TGAATACAGC CAACATGCTT TTAAGCTTGC AATCGCAGGT TTTAAGCTTT 360

GTGGTTGAAA ACGAACGCAA AAAAGCTTTT TTACAGATGA AAGCCAAAAA ACAAAGCGTT 420

GATTTTTACG CTCTGTACCC TAACTTGGGC GAAATTGGCG GCGTTATTTA TTTAAAAGAA 480

AAAGAGAAAC AGCTTTTTTT AAAAACCACC CTCCAAAGGA CCAAAGAGGT TTTAAAAGAG 540

GCTCAAAACA CCCTTTTAGG CTTTTCTTTT GTGGAAATTG TGTGCGAAAA AACCCCCATG 600

CTTTTTGCCT TTGAAGATCG CTTATTGGAC ACGCTAGGGT AA 642

(2) INFORMATION FOR SEQ ID NO: 308:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 276 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...276

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 308:

ATGTCAGATG AAATCACGCA AGAAAACGAG TTAGAAATTA ACTCCAATAA TCAAAACCAA 60

GAGCCAAAGG AAGTAGAAAA AATGCCATTG AATAATATTC AAAAAGCTAA GAAATTAAAA 120

AACCACGCCA ATTTAATTGT TCGACGCACT GATGAGTTAG ATAAGGTTAT CAATAAGCGT 180

GAAAGCTTGC AAAGAGAGTT TAAAAGACGC ATTAAGCACT TGGATAACAA GATTGAAACG 240

CTTAGTAACA ATATTGAAGA ATTAAAAAGA AAGTAA 276

(2) INFORMATION FOR SEQ ID NO: 309:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 519 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular (11 ) MOLECULE TYPE DNA (genomic)

(m) HYPOTHETICAL NO

(iv) ANTI-SENSE NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...519

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 309:

ATGAAAAAAT ATCAAAACAA ACGAAAGCTG GGTAAGCGTA TCAATTGCTT TATTTCAAAT 60

GAATGTAAGG ACATTTTAGA AAATTATTTA AAAGTCAAAA AAATTAGCGT TACTGAGTGT 120

ATAGAAAGCC TTTTATTAGC CCTAGACCCT AGCAAAGAAA CACTAAGAGC AAGGGATTTT 180

TATGAAAGTT TGTTTAAAGT CATCAGTCTT AACCAACATG TCTATAAAGA ACTCATGGCT 240

AATGGTAATA ACATTAACCA AATAGCCAAG AACACCAACA TTGCCATTAA GTATAACAAG 300

CCCTTTTATT TGCAGAATTT AGCATTCTTA GAAGAGATTT TTAAGGTTAT GGATACACTT 360

AATAAAAATG TAGAAGAATG TAAAAAAATC TCTTTGGAAT TATTACTTCA AATTTACAAA 420

GAACAAAAAA GCCAAACAGA ATTTAACGCC ATTTCAAAAA TTCTCAACGC TCTTAATGAA 480

AAACAATCTA CTACTGAGCC AAAAAAGGAC AACGCATGA 519

(2) INFORMATION FOR SEQ ID NO: 310:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 963 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...963

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:310:

ATGAACACTA ATTTAAAGAA AGCCTTGTTT TTAACTACTC TTGGTTATTT GCAAGCTAAT 60

GAGGGCTTTT TAGCCATTAT GCCTGATGAA AATAAACAAG AAGACATTTC TCAAGAACAG 120

AAATTAGAAC ACAAAATGGA GCAAAAAATT GCTCCACAAA ATACCCTTAA AAAGCAACAA 180

TCAGCTCCTT TACAAAGTGC TGAGTTGTTA CAAAGTCAAG TTAAAAGAGA AGTTAAAGAG 240

CAAAAAAAGT CTCAAAAACA CCTAGTAGCT ATGCAAACTA AAAATGGCTT TTTCTTAGGC 300

TCAGAAATTG CTATTACAGG CACAAGTTTA AAACAAAGTT TAAGCCTTAT TTCTAATGCT 360

ACAGATGATT TACTCACTTA TAGCAAGACT TCTAAAAACG CTAATTTTAA TATGGGACTA 420

TTAATAGGTT ATCAGCATTA TTTTGGAGCT AGTAAAAGGC ATGGGATTAA AATCTCAAGC 480 CATTTGTATG GAGGCACACC TAGTGATGTA AGCACAGACA TAAAAATTTA CAAATCTAAA 540

GTTAGCACCA ATTACACGCC TTTAAATTTT GGCATAGATG TGAAGTATTT GTTTGATTTT 600

TTAAATGTC TTAAAAAGAA CCGCCATACA CTAGGATTAA GTGTGGGCTT TGGCTGGCGT 660

ATGCAATATT ATTTTGCAAA AATAGACCCC ATAAAAACCA GCCATAGTGA GTTTATCACT 720

AATAAACCTA AAGATATTTT TAATCATGGT TTTTATCCCA CTATTGGACT ACATTATTAC 730

TTAAACCATC ATCAATTTGA AGTGAATTAT CGCTTTGGAG GAGCAATTAA CTATCAGTCA 840

GTTGTGCCTA GCAAAATTGT CGTTCAAAAC GGGAATTTTA AGGGCGAGGT CTTGTTTTCT 900

AATTTTCTTA CCAAAGCGAC TAATTCTAGC TACATAGCGT TCAACTACGC TTATTTATTT 960

TAA 963

(2) INFORMATION FOR SEQ ID NO: 311:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1461 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1461

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 311:

TTGGCTATTA AAAGGGAAAA AATGAAAAAT AGCGCGCCTT TAAAGAATAA AGTTTTTTGT 60

GGGTTATACG TTTTAAGTTT AAGCGCTTCT GTGCAAGCGT TTGATTATAA AATTGAAGTT 120

TTGGCAGAGT CCTTTTCTAA AGTTGGCTTT AATAAAAAAA AGATTGACAT AGCTAGGGGG 180

ATTTATCCTA CAGAGACTTT TGTAACCGCT GTGGGTCAGG GCAATATTTA TGCGGATTTT 240

TTATCCAAAA GCCTTAAAGA TCAAGGGCAT GTTTTAGAGG GAAAAGTCGG CGGCACAATC 300

GGTGGGATTG CTTATGACAG CACGAAATTC AATCAAGGCG GATCGGTTAT TTATAATTAT 360

ATCGGTTATT GGGATGGCTA TTTAGGGGGT AAAAGGGCCT TGCTTGATGG CACGAGTATC 420

CATGAGTGCG CGCTTGGCTC TGATGGCAAG GTGATTGATT CTATAGCGTG CGGGAACGCT 480

AGAGCCAATA AAATCCGCCG TAATTACTTG ATGAATAACG CTTTTTTAGA ATACCGCTAT 540

AAGGATATAT TTGCGGCTAA AGGGGGGCGT TATCAATCCA ATGCTCCTTA TATGAGCTCT 600

TATACGCAAG GCTTTGAAAT CAGCGCTAAA ATCAAGGATA AAAATGAGGG GAGCCATAAA 660

TTATGGTGGT TTAGCTCATG GGGTAGGGCG TTCGCTTATG GGGAGTGGAT TTATGATTTT 720

TACTCTCCAA GAACCGTGAT TAAAAACGGG CGCACTCTAA ATTATGGTAT CCATTTAGTG 780

GATTACACTT ACGAAAGGAA AGGGGTTAGC GTCAGCCCCT TTTTCCAGTT TTCGCCCGGG 840

ACTTATTATA GCCCTGGGGT GGCTGTAGGC TATGATAGTA ACCCTAATTT TAATGGCGTG 900

GGCTTTAGAT CCGAAACGAA GGCTTATATT TTGCTCCCTG TCCATGCCCC CCTTAAAAGG 960

GATACTTATC GTTACGCTGT GAAAGCTGGC ACCGCTGGGC AAAGCCTGCT CATTAGGCAA 1020

CGATTTGATT ACAATGAATT TAACTTTGGG GGAGCGTTTT ATAAAGTATG GAAAAACGCA 1080

AACGCTTACA TAGGCACGAC AGGAAACCCT CTAGGCATTG ATTTTTGGAC CAATAGCGTT 1140

TATGATATAG GGCAAGCCTT AAGCCATGTG GTAACCGCTG ATGCCGTCTC TGGTTGGGTT 1200

TTTGGTGGAG GCGTGCATAA AAAATGGCTG TGGGGGACTT TGTGGCGTTG GACTAGCGGC 1260

GCTTTAGCCA ATGAAGCGAG CGCGGCTGTT AATGTGGGCT ATAAGATCAG TAAGAGTTTG 1320

ACAGCGAGCG TGAAATTAGA ATATTTGGGC GTGATGACGC ATTCAGGCTT TACGGTAGGG 1380

AGTTACAGAC CCACGCCCGG CTCTAAAGCA CTTTATTCAG ACAGGAGCCA TCTAATGACA 1440 ACCCTTAGCG CCAAATTCTA A 1461 (2) INFORMATION FOR SEQ ID NO: 312:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 504 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...504

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 312:

GTGTGCATTA TTTTTGATGC AGACATAAAA AAAGAGAACC AAGAAAGCGA TGCAGGTTTT 60 GATAACAAGC TTAAGCATAT TCGTGAAAAA TTCAAAGAAA AAGGGACTGA TTTTCCCAAA 120 GAACAAATCT TTTTATTCCC TAACAATCAA GATGATGGCG ATTTAGAAAC CCTATTATTA 180 GAAATTGCTA AACACGATGA ATTTCTTAAA TGCTTTGAAG GATACTTAGA ATGTATTAAA 240 AGTAAAGAAC ATTATAAACC GATTAAAAAC ATAAGAAAAA ATATGCTGTA TGCCTATTTA 300 GAAGCGCTTG GATTAGAGAA TTTGACCAAG ACCAATATAG ATGTTTTTGA TAGTAAAGGT 360 AAAATAAAGA GTAGATATGA AGAAAACTAC AAAAAATTAA CAGAAGAAGT TATTGATTTC 420 AGCTCGAATT CTCTCATTCC CCTTAAAAAT TTTCTAGGGC AATTCGCAGA AAATAAACAA 480 AAAACAAATC CTAAAATTTT CTAA 504

(2) INFORMATION FOR SEQ ID NO: 313:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 633 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...633

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 313: ATGGTATTGA AAACAAAATT AAAAATTATA AGCTCGGTGA TTTTGAGTAC TTTATTGTGG 60

GTGGGTTGCT CAAGCGAAAT GGCGACTTAT CAAAATGTGA ATGACGCCAC TAAAAATACG 120

ACTGCAAGTA TTAATAGCAC GGATTTATTG CTAACCGCTA ACGCGATGTT AGATTCCATG 180

TTTAGCGACC CTAATTTTGA GCAACTCAAG GGCAAGCATT TGATTGAAGT TTCAGATGTG 240

ATTAACGACA CCACTCAGCC CAATTTGGAC ATGAATCTTT TGACGACCGA AATCGCGCGG 300

CAGTTGCGAT TGCGATCTAA TGGGAGGTTC AATATCACAA GGGCGAGTGG AGGGAGTGGT 360

ATTGAAGCAG ACAGCAGAAT GGTGAAACAG CGCGAAAAAG AACGAGAGAG CGAAGAGTAT 420

AATCAAGACA CCACTGTAGA AAAAGGCACT TTAAAAGCCG CTGATTTATC TTTAAGTGGT 480

AAAGTATCCA GTATCGCAGC CTCTATTAGT AGTTCTAGGC AACGCTTAGA CTACGACTTC 540

ACCCTAAGCC TTACCAATAG GAAAACGGGT GAAGAGGTAT GGAGCGATGT TAAGCCTATT 600

GTGAAAAATG CTAGCAATAA GCGTATGTTT TAA 633

(2) INFORMATION FOR SEQ ID NO: 314:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 555 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...555

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 314:

ATGAAAGCTT TTTTAAAGAT TTGCATGGTT TTGATTTTTG TGGGTGTCGC TCATGCTAAA 60

AATCCTTTAA CCCTTTCTAA AGAAGAAGAA GTTTTACAAA ATTTGCAAAG TTTTAGCGCG 120

CATTTCAAGC AAGTGTTAAA AAATGAAAAG CCCTTAGTTT ATTATGGGGT TTTAAAGGCT 180

AAAGCCCCTA ATTGGGCTTT ATGGGTTTAT GAAAAACCCT TAAAAAAAGA AATTTACATG 240

AACGATAAGG AAGTGGTGGT TTATGAGCCT AATTTATTCC AAGCGACTAT CACGCCCTTA 300

AAAGACAAGA CGGATTTTTT CACCATTCTC AAGCAATTGA AAAAGCAGAC TGACGGCTCT 360

TTTAAAACGA CTATCAACAA GACCACTTAT CGTTTGGTTT TTAAAGACGG CAAGCCTTTT 420

TCGTTGGAAT TTAAAGATGA CATGAATAAT CTTGTTACGA TCACTTTTTC TCAAGCAGAA 480

ATCAACCCTA AAATTCCTAA TGAAATCTTT GTTTTTAACC CTAAAGATGA AAATATTGAT 540

ATTGTACGCC AGTGA 555

(2) INFORMATION FOR SEQ ID NO: 315:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 558 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (ill) HYPOTHETICAL. NO

(iv) ANTI-SENSE NO

(vi) ORIGINAL SOURCE-

(A) ORGANISM- Helicobacter pylori

(ix) FEATURE.

(A) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 558

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 315-

ATGAGAATTA AGGCTTATTT TTTGCGTTTT ATCGCACTGG TTTTTATCGT TTTGTTGGGT 60

TTTAGCGCTT GTAAAAACTC TCAAAAATCT CAAGATTCTC AAAACAATAC CACCCAACAA 120

GATAGCCCTA AAACCTACAC CGCTATGGAT CTGAATAACC AAGAATACAC GATTATGGGC 180

GATTTAGATT CTCTAAACAT CAGCCCGGAT CCTAACACCC CTACCCTATT GATTTTAAGC 240

GCTTTAGATA ATTCTTTAAA AGATTACGCC CCCACCTTTA ACGTCTTAAA AAAAACTTTT 300

AAAGATCGTT TGAGGGTGCT TATTTTACTC AATCAACCCT ATTCAAGCGA TGCAATCAAA 360

GGCTTTATTG CGCCTTCTCA AACTGATTTG ATGATTTTAA ACCCTAAAGA TACCGCTCTT 420

TTTGATCATT TAAACCATGA CGCTTTAAAC CATTCTTTTA ACATGCTCTT ATATGACAAA 480

CACCAATTGA TTAAAATGTA TCAAGGGATC GTGCCAGCAG AAATGCTCCA ATTTGATATT 540

TCCAATTTAA AGGACTGA 558

(2) INFORMATION FOR SEQ ID NO: 316:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1092 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...1092

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 316:

ATGGTATCAA CACTCAAACC GCTAAAAATC GGTAAACACA CCATAAAATT CCCTATTTTT 60

CAAGGGGGCA TGGGTGTGGG GATTAGCTGG GATGAACTAG CTGGAAATGT TGCCAAAGAA 120

GGGGCTTTAG GAGTGATTTC AGCCGTAGGG ACTGGTTATT ATAAAAACAT GCGTTTTGTA 180

GAAAGGATTG TGGCTAAAAA ACCCTTTGAA GCCTTGAATT TTTACTCCAA AAAAGCGTTG 240

AATGAGATTT TTGCAAACGC TAGGAAAATT TGCGGGAACA AGCCTTTGGG GGCGAATATT 300

TTATACGCTA TCAATGACTA TGGCCGTGTT TTAAGGGACT CTTGTGAGGC GGGGGCGAAT 360

ATTATCATTA CAGGGGCTGG TTTGCCCACT AACATGCCTG AATTCGCTAA GGATTTTAGC 420

GATGTGGCGC TCATCCCTAT CATTTCCTCA GCGAAGGCTT TAAAAATCCT TTGTAAAAGA 480

TGGAGCGATC GCTATAAAAG AATCCCGGAC GCATTCATTG TGGAAGGGCC TTTGAGTGGG 540

GGGCATCAGG GCTTTAAATA CGAAGATTGT TTCAAAGAAG AATTCCAATT AGAAAACTTA 600 GTGCCTAAAG TCGTGGAAGC TTCTAAAGAA TGGGGGAATA TCCCTATCAT CGCCGCGGGG 660

GGGATTTGGG ATAAGAAAGA TATAGACACC ATGTTAAGCC TTGGAGCGAG TGGGGTGCAA 720

ATGGCGACTC GTTTTTTAGG CACGAAAGAA TGCGACGCTA AAGCGTATGC CGATCTTTTG 780

CCCACGCTCA AAAAAGAAGA TATTTTACTC ATCAAATCGC CTGTAGGCTA TCCGGCTAGG 840

GCTATCAATA CGGGGGTGAT CAAACGCATT GAAGAGGGTA ACGCGCCTAA AATCGCATGC 900

GTGAGCAATT GTGTAGCGCC TTGTAACAGG GGTGAAGAAG CTAAAAAGGT GGGCTATTGT 960

ATCGCTGATG GTTTGGGGCG CAGTTATTTA GGAAACAGAG AAGAGGGGCT TTATTTTACC 1020

GGGGCTAATG GCTATAGAGT GGATAAGATT ATCAGCGTGC ATGAATTGAT TAAAGAGCTT 1080

ACAGAGGGTT AA 1092

(2) INFORMATION FOR SEQ ID NO: 317:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1092 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1092

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 317:

ATGGTATCAA CACTCAAACC GCTAAAAATC GGTAAACACA CCATAAAATT CCCTATTTTT 60

CAAGGGGGCA TGGGTGTGGG GATTAGCTGG GATGAACTAG CTGGAAATGT TGCCAAAGAA 120

GGGGCTTTAG GAGTGATTTC AGCCGTAGGG ACTGGTTATT ATAAAAACAT GCGTTTTGTA 180

GAAAGGATTG TGGCTAAAAA ACCCTTTGAA GCCTTGAATT TTTACTCCAA AAAAGCGTTG 240

AATGAGATTT TTGCAAACGC TAGGAAAATT TGCGGGAACA AGCCTTTGGG GGCGAATATT 300

TTATACGCTA TCAATGACTA TGGCCGTGTT TTAAGGGACT CTTGTGAGGC GGGGGCGAAT 360

ATTATCATTA CAGGGGCTGG TTTGCCCACT AACATGCCTG AATTCGCTAA GGATTTTAGC 420

GATGTGGCGC TCATCCCTAT CATTTCCTCA GCGAAGGCTT TAAAAATCCT TTGTAAAAGA 480

TGGAGCGATC GCTATAAAAG AATCCCGGAC GCATTCATTG TGGAAGGGCC TTTGAGTGGG 540

GGGCATCAGG GCTTTAAATA CGAAGATTGT TTCAAAGAAG AATTCCAATT AGAAAACTTA 600

GTGCCTAAAG TCGTGGAAGC TTCTAAAGAA TGGGGGAATA TCCCTATCAT CGCCGCGGGG 660

GGGATTTGGG ATAAGAAAGA TATAGACACC ATGTTAAGCC TTGGAGCGAG TGGGGTGCAA 720

ATGGCGACTC GTTTTTTAGG CACGAAAGAA TGCGACGCTA AAGCGTATGC CGATCTTTTG 780

CCCACGCTCA AAAAAGAAGA TATTTTACTC ATCAAATCGC CTGTAGGCTA TCCGGCTAGG 840

GCTATCAATA CGGGGGTGAT CAAACGCATT GAAGAGGGTA ACGCGCCTAA AATCGCATGC 900

GTGAGCAATT GTGTAGCGCC TTGTAACAGG GGTGAAGAAG CTAAAAAGGT GGGCTATTGT 960

ATCGCTGATG GTTTGGGGCG CAGTTATTTA GGAAACAGAG AAGAGGGGCT TTATTTTACC 1020

GGGGCTAATG GCTATAGAGT GGATAAGATT ATCAGCGTGC ATGAATTGAT TAAAGAGCTT 1080

ACAGAGGGTT AA 1092

(2) INFORMATION FOR SEQ ID NO: 318:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 579 base pairs (3) TYPE nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

( i) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...579

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 318:

TTGTTAGGGA GGAATGGCGT TACTTTAAAT ATCCGCCAGG TTTTTTGGTG GGATAATTTC 60

AACTGGTCCA TTGGCTTTTA TAACACCTTT GGCAATTCAG ACGCTTTTTT AGGCTCTCAC 120

ACCATGCCAA GGGGGAATAA CACTTCCTAT ATCAGTAATG AAATCTCAGT AACGACTAGG 180

CATGCCGGAA TGATCGGCTA TGATTTTTGG GATAATACGG CTTATGATGG GCTGGCTGAT 240

GCGATCACTA ACGCGAACAC TTTCACTTTT TACACTTCGG TTGGAGGGAT CCATAAGCGT 300

TTTGCATGGC ATGTTTTTGG GCGCGTCTCT CATGCGAATA AAAATGCGTT AGGGCAAGTG 360

GGGAGGGCTA ATGAATATTC CTTGCAATTC AATGCGAGCT ATGCGTTCAC TGAATCGGTT 420

CTCCTTAACT TTAGGATCAC TTATTATGGG GCTAGGATCA ATAAAGGGTA TCAAGCAGGG 480

TATTTTGGAG CGCCCAAATT CAATAACCCG GATGGCGATT TTAGCGCTAA TTACCAAGAC 540

AGAAGTTACA TGATGACCAA CCTCACGCTG AAGTTTTGA 579

(2) INFORMATION FOR SEQ ID NO: 319:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1065 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...1065

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 319:

ATGCAACAAC AGCTCACCTA CTTGAATGCG GGGAATGTGT TTTTTAATGC GATGAATAAG 60

GCTTTAGAGA AGAATGGGAC TGCTACTGCT AATAGCACTA GTAGCACTAG CGGTGCGACT 120

GGTTCAGATG GTCAAACTTA CTCTCAACAA GCTATTCAAT ACCTTCAAGG CCAACAAAAT 180

ATCTTAAATA ACGCAGCGAA CTTGCTCAAG CAAGATGAAT TGCTCCTAGA AGCTTTCAAC 240 TCTGCCGTAG CTGCTAACAT TGGGAATAAG GAATTCAATT CAGCCGCTTT TACAGGTTTG 300

GTGCAAGGCA TTATTGATCA ATCTCAATTG GTTTATAACG AGCTCACTAA AAACACCATT 360

AGCGGGAGCG CGGTTAATAA CGCTGGGATA AACTCCAACC AAGCTAACGC TGTGCAAGGG 420

CGTGCTAGTC AGCTCCCTAA CGCTCTTTAT AACGTGCAAG TAACTTTGGA TAAAATCAAC 480

GCGCTCAACA ATCAGGTGAG AAGCATGCCT TACTTGCCCC AATTCAGAGC CGGGAACAGC 540

CGTGCAACGA ATATTTTAAA CGGGTTTTAC ACTAAAGTGG GCTATAAGCA ATTCTTCGGG 600

AAGAAAAGGA ATATCGGTTT GCGCTATTAT GGTTTCTTTT CTTATAACGG AGCGAGCGTG 660

GGCTTTAGAT CCACTCAAAA TAATGTAGGG TTATACACTT ATGGGGTGGG GACTGATGTG 720

TTGTATAACA TCTTTAGCCG CTCCTATCAA AACCGCTCTG TGGATATGGG CTTTTTTAGC 780

GGTATCCAAT TAGCCGGTGA GACCTTCCAA TCCACGCTCA GAGATGACCC CAATGTGAAA 840

TTGCATGGGA AAATCAATAA CACGCACTTC CAGTTCCTCT TTGACTTCGG TATGAGAATG 900

AACTTCGGTA AGTTGGACGG GAAATCCAAC CGCCACAACC AGCACACGGT GGAATTTGGC 960

GTAGTAGTGC CTACGATTTA TAACACTTAT TACAAATCAG CAGGGACTAC CGTGAAGTAT 1020

TTCCGTCCTT ATAGCGTTTA TTGGTCTTAT GGGTATTCAT TCTAA 1065

(2) INFORMATION FOR SEQ ID NO: 320:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2247 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...2247

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 320:

ATGGAAGACT TTTTGTATAA CACCTTATAT TTCATAGAGG ATTATAAGTT GGTTGTTATT 60

TTTAGTTTCA TAGGGTTAAT AGCGTTATTT TTCCTCTACA AATTCATAAA AACTCAAAAA 120

AAGGTTTTTA AAGATAAAGC TAACCAGCCT CAAAAGAAAA AAAGCTTTAA AGAAATCATT 180

ATAGATGGGC TGAAAGAAAG GGTTAAAACC TTTGGCTTTT GGTTGCAAGC TATACTATTA 240

CTATCCTATT CTTTTATCAC ATCAGGGTTA TTTTTCTTGA TTCTCTTAGG TAATTTTTAT 300

GATGATAATA GATTGCCTGA GAGCGATGAT GATCTTTTTG ATATATGGGT CTATGCGATA 360

CAAGATTTTC CTGCATACTA TTTTAAGGCA CTCACTTTTA GCTCGCTCAA GATTTATGGG 420

TTCAATATAT CCTTAGTCGT ATATAGTTCT ATTTTATGCT CTTATATATT CATTACCTTT 480

TTTGTGTGGT TCTTAAAATA CTTAACTCGG ACTAGGGACA TAGGAGCGAA TAAAAAAGTT 540

GATGATCTCT TTGGTAGCGC GAGTTGGGAA ACTGAAGAGA AAATGATCAA AGCCAAGCTT 600

ATCACACCCA ACAATAAAAA ACGCGCCTTT GACAAACGAG AGGTTATTGT AGGCAGGCGT 660

GGCTTAGGGG ATTTTATCGC TTACGCAGGA CAGGCGTTTA TTGGCTTGAT TGCTCCTACT 720

AGGAGCGGTA AGGGTGTGGG TTTCATCATG CCCAATATGA TCAATTACCC TCAAAATATC 780

GTTGTGTTTG ATCCTAAGGC TGACACTATG GAAACTTGCG GGAAAATCAG AGAAAAACGC 840

TTCAACCAAA AAGTGTTCAT CTATGAACCT TTCTCCTTAA AAACACACCG ATTTAATCCT 900

TTCGCTTATG TGGATTTTGG TAATGATGTG GTTTTGACTG AAGACATACT CTCTCAAATT 960

GACACACGCC TAAAAGGGCA TGGCATGGTG GCTAGTGGAG GGGATTTTTC CACTCAAATC 1020

TTTGGATTGG CTAAGTTGGT GTTCCCTGAA AGACCTAATG AAAAAGATCC TTTTTTTAGC 1080

AATCAGGCGC GAAACCTTTT TGTCATCAAT TGCAATATTT ATAGGGATCT CATGTGGACT 1140 AAAAAGGGGC TTGAGTTTGT CAAAAGAAAA AAAATCATCA TGCCTGAAAC CCCCACGATG 1200

TTTTTCATAG GTTCTATGGC AAGCGGTATC AACTTGATTG ATGAAGACAC AAACATGGAA 1260

AAAGTCGTGT CTTTAATGGA ATTTTTTGGA GGTGAAGAAG ATAAGAGTGG CGACAATCTA 1320

AGAGCGCTTA GTCCTGCCAC TAGAAACATG TGGAATAACT TCAAGACAAT GGGTGGCGCT 1380

AAAGAAACTT ACAGCTCGGT TCAAGGGGTC TATACATCAG CGTTTGCGCC TTACAATAAC 1440

GCCATGATCA GGAATTTCAC GAGCGCTAAT GATTTTGATT TCAGGCGTTT AAGGATCGAT 1500

GCAGTGAGTA TTGGTGTGAT CGCTAATCCT AAAGAAAGCA CTATTGTTGG ACCGATATTA 1560

GAGCTGTTTT TCAACGTGAT GATTTATAGC AATTTGATTC TGCCAATCCA TGATCCACAA 1620

TGCAAAAGAA GCTGCTTGAT GCTCATGGAT GAATTTACGC TCTGTGGCTA TTTAGAGACC 1680

TTTGTTAAAG CGGTAGGGAT CATGGCAGAA TACAACATGC GCCCCGCTTT TGTGTTTCAA 1740

AGTAAGGCGC AATTAGAAAA CGACCCCCCA CTTGGTTATG GTAGGAATGG CGCTAAGACT 1800

ATTTTAGACA ACCTTTCTTT GAATATGTAT TATGGGATCA ACAACGATAA CTACTATGAA 1860

CATTTTGAAA AGCTTTCTAA AGTGTTAGGG AAATACACAA GGCAAGATGT GAGCCGGAGC 1920

ATTGATGATA ATACGGGTAA GACCAACACT TCTATCAGCA ACAAGGAGCG GTTTTTGATG 1980

ACCCCTGATG AATTGATGAC TATGGGCGAT GAGCTTATCA TTTTAGAAAA CACGCTCAAA 2040

CCCATCAAGT GCCACAAGGC GCTTTACTAT GATGATCCCT TCTTCACCGA TGAGCTCATT 2100

AAGGTGAGTC CAAGCTTGAG CAAGAAATAC AAATTGGGGA AAGTGCCTAA TCAAGCAACA 2160

TTTTATGATG ACTTGCAAGC CGCTAAAACC AGAGGCGAAT TGAGCTATGA TAAATCTTTA 2220

GTGCCTGTGG GTTCAAGCGA ACTGTGA 2247

(2) INFORMATION FOR SEQ ID NO: 321:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 105 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...105

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 321:

TTGAGCCATT TATTTCTCGT AAAACGCCCT TACAGTCGCC TTTATTTACA TAATCAGAGC 60 AACCATAAAA TGAGACACCA TTCAATCCTC TTTGTATCAT TTTAG 105

(2) INFORMATION FOR SEQ ID NO: 322:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 333 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE- NO

(vi) ORIGINAL SOURCE.

(A) ORGANISM. Helicobacter pylori

(ix) FEATURE

(A) NAME/KEY. mιsc_feature

(B) LOCATION 1.. 333

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 322:

ATGGAACACC ATAAAGCGCA CACAACCATT CAGGCTTTAC AAGCCAAACG CAAAAGGTTG 60

CTAACCGAAT TAGCCGAGTT AGAAGCAGAA ATAAAGGTGA GCAGCGAACG AAGGAGCAGT 120

TTTAACGTTT CGCTCTCGCC GAGTTTGTTA GCCGAAATAG AAGAGATAGA ATACGAAGAA 180

AAAATGAGCA AAGAGCGAAG AATCCATCAC AATCTTTTGC TTTCGCCCAG TTTCATGGCT 240

AAAGTGGATG AATACATGAA AGAGAAAGGT TTTCCTAATC GATCGCTTCT CTTTGAAAAA 300

GCGTTGGAGT TTTATATGCT AAAACACCCA TAA 333

(2) INFORMATION FOR SEQ ID NO: 323:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 477 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...477

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 323:

GTGATGCGTT TCTTTTCATT CTGTTATTTT TTATTTTATT TTTTAGGGGT TTCTTTGCAT 60

GCCCTTAGCC CCCTAGAAGA ACAAGAATTT TTAATTTCGT ACCGCTTGAA AATCGTTGAT 120

TCTAGAGTGA TGGGTGAAGA GTATTCTGTT TCTAAACCTA TCGTTAGTCG CATTAAAACA 180

GCCCCCTATG TTTTAGACTA TCATTGCTCT ATCATCACTC GCAACTTGCC CGATTTGAAA 240

AACCCCTTGC TCCAAATAAA GCTAGAACGC TTCCTTTTAG AAATAGCGTT AAAAAAAGAA 300

AAAGAGCGAG TCATTGACTG CCTTTTAAAA AGCCAAGTCG CTATCACGCA TTATGATCAC 360

AGCTATAAAA ACGGCACCAC TACCACAAGC ATTCTTAACC TCAAAGCCTT AAGCGTTAAA 420

GCGAGTTTAG AGGGAGATAT GCTGTCTTTA GATATTTTTA GAAAGGAAGA AGAATGA 477

(2) INFORMATION FOR SEQ ID NO: 324:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 351 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double (D) TOPOLOGY circular

(11) MOLECULE TYPE. DNA (genomic)

(ill) HYPOTHETICAL NO

(iv) ANTI-SENSE- NO

(vi) ORIGINAL SOURCE.

(A) ORGANISM. Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...351

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 324:

ATGGAGTTAA TTAAGAAATT GGAAAAAGAA AGCGAAGTTT TAAAGAAAGA TTTACAACAA 60

CATTCAAACG AGCTTTTTAA AATGTTGATT ATTGATAATG AAGATTTGTT TAAAGAGCAA 120

TTTGAGATTA TGTTTAAAGC ATGGGTTGAA ATCGTAAAAA TGATGTTTGA ATTAACCAAA 180

AAAACCAAAT TTGATGGCGA AATGATTGGC TACACAGAAG AACTTTTAAC CTTTTTAGTT 240

AGAGATTTTT TTAATGGGAT TTTTAAATCC AAAGTAATAC CTAAAATGCC TATTTTTTGC 300

GGTGATGTTA AATGCGAAGA TTTTAATGCC CTAAGAAGTT TAGTTTATCT T 351

(2) INFORMATION FOR SEQ ID NO: 325:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 834 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...834

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 325:

TTGAAACGAG CGTTATGGTT AATTTTAGGG CTTTTTTACG CGCTTAATGC AGAGAGCTTT 60

AAAGATGTTT TGACTAAAGG GGATTACACT TTTTTTAATA AAAAGGTGGT TTCGCCTATC 120

AAACGCTATG CGGATAGATC GGCGTTTTAT CTGGGGCTTG GGTATCAATT AGGGAGCATT 180

CAGCACAACT CTAGCAACTT GAATTTATCC CAACGATTTA ATAAGAGTCA GATTATTTTC 240

AGCGATAGTC TAAGCCCTGT TTTTAAAAAT TCGTATGTGT CTAATGGTCT TGGCGTTCAA 300

GTGGGCTATA AGTGGGTGGG TAAGCATGAA GAGACGAAAT GGTTTGGCTT CAGGTGGGGG 360

CTGTTTTATG ATTTGAGCGC TTCTCTTTAT GGCTCTCAAG AATCGCAGTC TATCATCATT 420

TCCACTTACG GCACTTATAT GGATTTATTG CTTAACGCTT ATAATGGGGA TAAGTTTTTT 480

GCCGGGTTCA ATCTGGGGAT CGCTTTTGCT GGAGTGTATG ACAGATTGAG CGATGCGTTA 540

TTGTATCAAA CTCTTCTTCA AAACACTTTT GGCGGGAAAG TGAATTTAAA CGGCTTCCAG 600 TTTTTGGTGG ATTTAGGGGT TCGTTTAGGG AATGAACACA ACCAATTTGG CTTTGGGATT 660

AAAATCCCTA CTTATTATTT TAACCATTAT TATTCCATGA ATAACATTAG CAATAATAGT 720

GAAAATGTCT TAAAAGTTTT ACGATTTTTA GAATACGGGA TCAACAGCTT GTTGTATCAA 780

GTTGATTTCA GGCGCAATTA CTCGGTTTAT TTCAACTACA CTTATAGTTT TTAA 834

(2) INFORMATION FOR SEQ ID NO: 326:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1482 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1482

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 326:

ATGCCTGCCT TGAATAGCTC CAAAAATATG GTAGTCAATA TCAATCAAAC TTTCACAAAA 60

AACCCTACCA CAGAATACAC TTACCCCGAT GGGAATGGCA ATTATTATTC AGGCGGTTCA 120

TCAATCCCAA TCCAGCTAAA GATTAGTAGC GTCAATGACG CTGAAAACCT TTTGCAACAA 180

GCCGCTACTA TCATCAATGT CCTTACCACC CAAAACCCGC ATGTGAATGG TGGCGGTGGG 240

GCATGGGGGT TTGGCGGTAA GACCGGGAAT GTGATGGATA TTTTTGGCGA TAGTTTTAAC 300

GCTATTAACG AAATGATCAA AAACGCTCAA GCCGTTTTAG AAAAAACCCA ACAGCTTAAC 360

GCTAATGAAA ACACCCAAAT CACGCAACCA GACAATTTCA ACCCCTACAC TTCTAAAGAC 420

ACGCAGTTCG CTCAAGAAAT GCTCAATAGA GCTAACGCTC AAGCAGAGAT TTTGAGCTTA 480

GCCCAACAAG TAGCGGACAA TTTCCACAGC ATTCAAGGGC CTATCCAACA AGATCTAGAA 540

GAATGCACCG CAGGATCAGC TGGTGTGATT AACGACAACA CTTATGGTTC AGGTTGCGCG 600

TTTGTGAAAG AGACTCTCAA TTCCTTAGAG CAACACACCG CTTATTATGG CAACCAGGTC 660

AATCAGGATA GGGCTTTGTC TCAAACCATT TTGAATTTTA AAGAAGCCCT TAGCACTTTA 720

GGGAACGACT CAAAAGCGAT CAATAGCGGT ATCTCTAACT TGCCTAACGC TAAGTCCCTT 780

CAAAACATGA CGCATGCCAC TCAAAACCCT AATTCCCCAG AAGGTTTGCT CACTTATTCT 840

TTGGATACCA GCAAATACAA CCAGCTCCAA ACTGTTGCGC AAGAATTAGG CAAAAACCCC 900

TTTAGGCGCA TCGGCGTGAT TAACTATCAA AACAATAACG GGGCGATGAA CGGCATCGGC 960

GTGCAAGCGG GCTATAAGCA ATTCTTTGGC AAAAAAAGGA ATTGGGGGTT AAGGTATTAT 1020

GGTTTCTTTG ATTATAACCA TGCTTATATC AAATCTAATT TTTTTAACTC GGCTTCTGAT 1080

GTGTGGACTT ATGGGGTGGG TATGGACGCG CTTTATAACT TCATCAACGA TAAAAACACC 1140

AACTTTTTAG GCAAAAATAA CAAGCTTTCT GTGGGGCTTT TTGGTGGCTT TGCGTTAGCC 1200

GGGACTTCGT GGCTTAATTC CCAACAAGTG AATTTGACCA TGATGAATGG CATTTATAAC 1260

GCTAATGTCA GCGCTTCTAA CTTCCAATTT TTGTTTGATT TAGGCTTGAG AATGAACCTC 1320

GCTAGGCCCA AGAAAAAAGA CAGCGATCAT GCCGCTCAGC ATGGCATGGA ATTGGGCGTG 1380

AAAATCCCCA CCATTAACAC GGATTATTAT TCTTTCATGG GGGCTGAACT CAAATACAGA 1440

AGGCTCTATA GCGTGTATCT CAATTATGTG TTTGCTTACT AG 1482

(2) INFORMATION FOR SEQ ID NO:327:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH. 810 base pairs

(B) TYPE, nucleic acid

(C) STRANDEDNESS- double

(D) TOPOLOGY, circular

(ii) MOLECULE TYPE- DNA (genomic)

(ill) HYPOTHETICAL. NO

( v) ANTI-SENSE: NO

(vi ) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...810

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 327:

GTGCTAAACA CCACCCAAAA AAGCCTATTG GTTTTCATGG GGGTTTTTTT CCTTATCTTT 60

GGCGTGGATC AAGCGATTAA ACACGCTATT TTAGAGGGGT TTCACTATGA AAGTTTGGTT 120

ATAGATATTG TTTTAGTGTT CAATAAAGGC GTGGCGTTTT CCTTACTCAG TTTTTTAGAG 180

GGGGGTTTGA AATACTTGCA AATCCTTTTA ATTTTAGGGC TTTTTATCTT TTTAATGCGC 240

CAAAAGGAGC TTTTTAAAAG CCATGCGATA GAGTTTGGCA TGGTGTTTGG CGCTGGGGTT 300

TCTAATGTTT TAAATCGGTT AGTATCATTG GGGCAATTGT ATATTCTTTA TGATGTATTG 360

GCTATTAGAA GGGAAAAAAT GAAAAATAGC GCGCCTTTAA AGAATAAAGT TTTTTGTGGG 420

TTATACGTTT TAAGTTTAAG CGCTTCTGTG CAAGCGTTTG ATTATAAAAT TGAAGTTTTG 480

GCAGAGTCCT TTTCTAAAGT TGGCTTTAAT AAAAAAAAGA TTGACATAGC TAGGGGGATT 540

TATCCTACAG AGACTTTTGT AACCGCTGTG GGTCAGGGCA ATATTTATGC GGATTTTTTA 600

TCCAAAAGCC TTAAAGATCA AGGGCATGTT TTAGAGGGAA AAGTCGGCGG CACAATCGGT 660

GGGATTGCTT ATGACAGCAC GAAATTCAAT CAAGGCGGAT CGGTTATATA TAATTATATC 720

GGTTATTGGG ATGGCTATTT AGGGGGTACA AAGGCCTGCT TGATGGCACA AGTATCCATG 780

ACTGCGCGCT TGGCTCTGAT GGCAAGGTGA 810

(2) INFORMATION FOR SEQ ID NO: 328:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 597 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...597

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 328: ATGTTAGTTA CAAAACTTGC CCCCGATTTT AAAGCGCCTG CCGTTTTAGG AAACAATGAG 60

GTTGATGAAC ACTTTGAGCT TTCTAAAAAT TTAGGCAAAA ATGGTGTGAT CCTTTTCTTT 120

TGGCCAAAAG ATTTTACTTT TGTATGCCCT ACAGAAATCA TTGCGTTTGA CAAAAGAGTG 180

AAAGACTTCC ACGAAAAAGG CTTTAATGTG ATTGGCGTGT CTATTGACAG CGAACAAGTG 240

CATTTCGCAT GGAAAAACAC CCCTGTGGAA AAAGGCGGTA TCGGTCAAGT GTCTTTCCCT 300

ATGGTGGCTG ATATCACTAA GAGCATTTCT AGAGACTATG ATGTGCTGTT TGAAGAAGCG 360

ATCGCTTTGA GAGGTGCTTT TTTGATTGAT AAAAACATGA AAGTAAGACA CGCAGTGATC 420

AATGACTTGC CATTAGGTAG GAATGCAGAT GAAATGCTTC GCATGGTAGA CGCTCTCTTA 480

CACTTTGAAG AACATGGTGA AGTATGCCCA GCAGGTTGGA GAAAAGGCGA TAAAGGCATG 540

AAAGCAACTC ACCAAGGCGT TGCAGAGTAT CTTAAAGAAA ATTCCATTAA GCTTTAA 597

(2) INFORMATION FOR SEQ ID NO: 329:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 648 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...648

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 329:

ATGTTAAAAC TCGCCAGTAA AACGATTTGT TTGTCCCTAA TCAGCTCATT CACGGCTGTA 60

GAAGCCTTTC AAAAACACCA AAAAGACGGC TTTTTCATAG AAGCCGGCTT TGAAACCGGG 120

CTATTACAAG GCACACAAAC CCAAGAACAA ACCATAGCCA CCACTCAAGA AAAACCCAAA 180

CCCAAACCCA AACCAAAACC CATTACCCCT CAAAGCACCT ATGGGAAATA CTACATCTCC 240

CAAAGCACCA TTTTAAAGAA TGCGACTGAG TTGTTTGCAG AGGATAATAT CACCAACTTA 300

ACCTTTTACT CTCAAAACCC TGTGTATGTA ACCGCTTATA ACCAAGAAAG CGCTGAAGAA 360

GCTGGCTATG GTAATAACAG CTTGATTATG ATACAAAACT TCTTGCCTTA TAACTTGAAC 420

AACATTGAGC TGAGTTACAC GGACGATCAA GGCAATGTGG TCAGTTTGGG CGTGATAGAG 480

ACTATCCCTA AACAATCTCA AATCATTCTG CCCGCAAGCT TGTTTAACGA CCCACAGCTT 540

AACGCCGATG GCTCCAACAA CTCCAAACCA ACACCACACG ATTTTCTGAT GCCAGCACGC 600

AGAATCTGTT TAACAAGCTC AGCAAGGTTA CAACCAATCT TCAAATGA 648

(2) INFORMATION FOR SEQ ID NO: 330:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 507 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...507

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 330:

ATGTTATCTT CTAATGATTT GTTTATGGTC GTTTTAGGGG CGATTTTATT GGTGTTGGTG 60

TGCTTGGTGG GGTATTTGTA TCTTAAAGAA AAAGAGTTTT ACCATAAAAT GAGGCGTTTA 120

GAAAAAACTT TAGATGAATC CTATCAAGAA AATTATCTCT ATTCTAAGCG TTTGAGAGAA 180

TTAGAGGGGC GTTTGGAAGG CCTTTCTTTA GAAAAAAGCG CTAAAGAGGA CAGCTCATTA 240

AAAACGACTC TTTCGCACCT TTATAACCAG TTGCAAGAAA TCCAAAAATC CATGGATAAA 300

GAGCGCGATT ACTTAGAAGA AAAAATCATT ACTTTAGAAA ACAAATTTAA AGACATGGGG 360

CATTATGCCG CTAGCGATGA AGTCAACGAA AAACAGGTTT TGAAAATGTA TCAAGAAGGC 420

TATAGCGTGG ATTCTATTTC TAAAGAATTT AAAGTGAGTA AGGGCGAGGT GGAATTTATA 480

TTGAACATGG CAGGGTTAAA ATGGTAG 507

(2) INFORMATION FOR SEQ ID NO: 331:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1017 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1017

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 331:

GTGGGTTTTG AATATTCCAT CAGTCATGCC GTTGAACACA ATAACCCTTT TTTGGATCAA 60

GAACGCATCC AAGCGATTTC TAACGCTCGA GGCGAAGTCT GTGGACTCGA TCGAGTCAAA 120

AATGAAATCA CAGACATGCC CAACACCTTT AACTACATCA ACAACGCTTT AAAAAACAAT 180

GCTAAATTAA CCCCTACTGA AAAGCAAGCC GAAACCTACT ACCTGCAATC TACCCTTCAA 240

AACATTGAAA AAATAGTCAT GCTTAGCGGG GGCGTTGCGT CTAACCCTAA ATTAGCCCAA 300

GCGTTAGAAA AAATGCAAGA ACCCATTACT AACCCTTTAG AATTGGTAGA AAACTTAAAA 360

AATTTAGAAT TACAATTCAG CCAATCTCAA AACAGCATGC TTTCTTCTTT GTCTTCTCAG 420

ATCGCTCAAA TTTCAAATTC TTTGAACGCG CTTGATCCCA GCTCTTATTC TAAAAACGTT 480

TCAAGCATGT ATGGGGTAGG TTTGAGCGTA GGGTATAAGC ATTTCTTTAC CAAGAAAAAA 540

AATCAAGGGT TTCGTTATTA CTTATTCTAT GACTATGGTT ACACTAATTT TGGTTTTGTG 600

GGTAATGGCT TTGATGGTTT AGGCAAAATG AATAACCACC TCTATGGGCT TGGCATAGAT 660 TATCTTTTCA ATTTCATTGA TAATGCGCAA AAACATTCGA GCGTGGGGTT TTATGTAGGC 720

TTTGCTTTAG CGGGGAGTTC GTGGGTAGGG AGTGGTTTAG GCATGTGGGT GAGTCAAATG 780

GATTTCATCA ACAACTATTT GACGGATTAT CGGGCTAAAA TGCACACGAG TTTTTTCCAA 840

ATCCCTTTGA ATTTTGGGGT TCGTGTGAAT GTGGATAGGC ACAATGGTTT TGAAATGGGC 900

TTAAAGATCC CTTTAGCGGT CAATTCCTTT TATGAAACGC ATGGCAAGGG GTTAAACGCT 960

TCCCTCTTTT TCAAACGCCT TGTCATGTTT AACGTGAGTT ATGTTTATAG TTTTTAG 1017

(2) INFORMATION FOR SEQ ID NO: 332:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 243 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...243

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 332:

ATGATGTTTG AATTAACCAA AAAAACCAAA TTTGATGGCG AAATGATTGG CTACACAGAA 60

GAACTTTTAA CCTTTTTAGT TAGAGATTTT TTTAATGGGA TTTTTAAATC CAAAGTAATA 120

CCTAAAATGC CTATTTTTTG CGGTGATGTT AAATGCGAAG ATTTTAATGC CCTAAGAAGT 180

TTAGTTTATC TTTCTGTGCT TGAGTTGGAA GAAACGATAA ATCCTAATAA AATCCCATTT 240

TAA 243

(2) INFORMATION FOR SEQ ID NO: 333:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 603 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...603 (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 333:

GTGCAATTAC TCAAAGACAA TAAAGAAGTG GTTGTTTTAG ATACAGATAG CCAAAAGTCT 60

ATGGAAACTT TTGCTACAAT TCGTGCTGAA AAAGAACGCC CCACTTTTAG CTTATTTAAT 120

CGTAGTAGTG GCTTTAGCGA TACTTTAAAG CAAATGGTAT CTAAGTATGA AAATATCCTT 180

ATTGATACTA AGGGGGAATA CAGCAAAGAA ACCCAAAAAG CTATGCTTTT AAGTAATATT 240

GTGCTAGTGC CAACAACTCC TAGCCAATTA GACACTGAAG TCTTAGCTAA TATGCTAGAA 300

AGAATTGAGC AACTCCAAGA GCTTAATGAA AATCTAAGAG CCTTAATTGT CATCAATAGA 360

ATGCCTACTA TTCCTACCCT TAAAGAAAGA CAAGCCTTAA TAGAGTTTAT TAAAGAAAAT 420

AACCCTAGCG ATAGGATTAC ACTTTTAGAA AGCTCTTTGA GTGAGCGCAT TGTTTATAAG 480

CGCAGTGTAA GCGAAGGCTT AGGGGTCATA GAATACAGCG ATAAAAAGGC TATCAATGAG 540

TGGGTTAATT TTTATAACGA ATTAAAAAGC CATTTAGAAA AAGAGAAAAT ACATACGTTT 600

TAG 603

(2) INFORMATION FOR SEQ ID NO: 334:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 213 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...213

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 334:

ATGCGGTCGG ATGTTGAAGT TTTATCGCCT TTGCATAAAA TAGATGAAAA ATACCTTTTC 60

CATTTAAAGA TTGCGGGGGA ATTGGCGAGC ATGGGTAAGA TTTTAAGTGT ATATTTAGCC 120

CACAAGCACA GCGCGTATTT CATTTTAAAC GCTTTGAGTT ACGGCTTTAG CCACCAGGAT 180

AGGGCGATCA TTTGCTTATT GGGCGCAATT TAG 213

(2) INFORMATION FOR SEQ ID NO: 335:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 213 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE: (A) ORGANISM Helicobacter pylori

(ix) FEATURE

(A) NAME/KEY mιsc_feature

(B) LOCATION 1 ..213

(x ) SEQUENCE DESCRIPTION. SEQ ID NO 335

ATGAGTGCGA TGATGCCAAG CCTTTTGACC TTGCAGTGGC TGAGTTTTAT CCTTTCTTTA 60

GCCGAAAATT TGTGCCTGAC AGACAGCCAT CATTTAAAAT ACACGCTAGA AAAAAACAAG 120

CTTGTGATCC ATTCTAATGA TGCGCTTTAC TTGGCTAAAG AAATGCTCCC CAAACTCATT 180

AAGCCCATTC CTTTGACGAT AGAGTTTGCT TGA 213

(2) INFORMATION FOR SEQ ID NO: 336-

(l) SEQUENCE CHARACTERISTICS.

(A) LENGTH: 1437 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL. NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY. mιsc_feature

(B) LOCATION 1...1437

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 336:

TTGAAGAAAA TCGCCCTTAT TTTAGATGGC ATTGTAGCAA AAAATTTTTT AGACTTGGTG 60

CTAAGGCATT ATTCTAATCA TAATTTTTAT ATAGTGGTTG TCAAAGATGA GAGCCTTATC 120

CCTAAAAATT ACCCGAGCAC TTTCGCTTTT CATTGTTTTG ATGCGACTTC CAGTTTTAGG 180

CTTTTGCAGG TGTTAAATGA TGAGGTGAGC GATGCGTTTT TAATCATACA AGATTTTAAA 240

GAGCAGCGCA TCATCCATAA AATCATTCAA ACCCATTTCA AACGCATGCG TGTGGTTTTG 300

AGCGTGAAAA GAGATAGCGA AAAAACTTTA GAAAACAATG AAGAAAATAA AGATGAAAAG 360

CTCATTTTGA TTGATGAATT TGAAGTTTTA GCCAATAAAT TCATTTCTCG TTTGCCTAAT 420

ATCCCTAGCA CCCCTAGAGA GTTTGGGTTA GGCAAGGGCG AGATCATGGA GATTGATGTG 480

CCTTTTGGGA GCATTTTTGC TTATAGGCAT ATTGGCTCTA TCAGGCAAAA AGAATACAGG 540

ATTGTAGGGC TTTATCGCAA CGATGTTTTG TTGCTCTCCA CTAAATCTTT AGTCATCCAA 600

CCACGAGACA TTCTTTTAGT GGCAGGCAAT CCGGAAATTT TAAACGCGGT GTACCATCAA 660

GTCAAAAGCA ATGTGGGGCA GTTCCCAGCC CCCTTTGGTA AGAGCATTTA TTTATACATT 720

GATATGCGAT TGCAGAGCCG AAAAGCGATG ATGCGCGATG TGTATCAAGC CTTGTTTTTG 780

CACAAGCGTT TAAAGAGCTA CAAGCTCTAC ATTCAGGTTT TACACCCCAC TAGCCCTAAG 840

TTTTATCATA AATTTTTATC GCTAGAAACC GAAAGCATTG AAGTGAATTT TGATTTTTAT 900

GGGAAGAGTT TTATCCAAAA ACTCCATGAA GACCACCAAA AAAAAATGGG TTTGATTGTG 960

GTAGGCAGAG AGCTTTTTTT CTTGAAAAAA CACCGAAGAG CCTTGCACAA AACAGCCACA 1020

CCGGTTTATA AAACCAACAC CTCTGGCCTG TCTAAAACCA CTCAAAGCAT TGTGGTTTTG 1080

AATGAAAGTT TAAGCATTAA TGAAGACATG TCTTCAGTGA TTTTTGATGT GTCTATGCAA 1140

ATGGATTTGG GCTTGTTGCT TTATGATTTT GACCCTAACA AGCACTATAA AAACGAGATT 1200

GTCAATCATT ACGAAAATTT AGCCAACACC TTTAACCGCA AGATTGAGAT TTTTCAAACC 1260 GATATTAAAA ACCCTATCAT GTATCTCAAT TCTTTAAGAA ATCCCATTTT GCATTTCATG 1320 CCTTTTGAAG AGTGCATCAC GCAAACGCGC TATTTGTGGT TTTTATCCAC TAAAGTGGAA 1380 AAATTAGCGT TTTTGAACGA TGATCACCCT CAAATTTTTA TCCCTGTAGC GGAGTGA 1437

(2) INFORMATION FOR SEQ ID NO: 337:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1257 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ll) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(v ) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...1257

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 337:

ATGAAAAAAG TCTATTTTAA AACTTTTGGG TGTAGGACGA ATCTTTTTGA CACGCAAGTG 60

ATGGGCGAAA ATTTAAAGGA TTTTAGCGCG ACTTTAGAAG AACAAGAAGC CGATATTATT 120

ATTATCAATT CTTGCACCGT AACCAATGGG ACCGATAGCG CGGTAAGGAG TTACGCTAGA 180

AAAATGGCAC GATTGGATAA AGAAGTGCTA TTTACTGGTT GCGGGGTGAA AACCCAAGGC 240

AAAGAGCTTT TTGAAAAAGG GCTTTTAAAG GGCGTTTTTG GGCATGACAA TAAAGAAAAG 300

ATTAACGCGC TTTTACAAGA AAAAAAGCGT TTTTTCATAG ATGACAATTT AGAAAACAAA 360

CATTTAGACA CCACGATGGT GAGCGAGTTT GTGGGAAAAA CCAGGGCGTT TATCAAGATC 420

CAAGAGGGCT GTGATTTTGA TTGCAATTAT TGCATTATCC CAAGCGTGAG AGGGAGGGCT 480

AGGAGTTTTG AAGAGAGGAA AATTTTAGAG CAAGTGGGCC TTTTATGCTC TAAAGGGGTT 540

CAAGAAGTGG TTTTAACCGG CACTAACGTG GGGAGCTATG GGAAAGATAG AGGAAGCAAT 600

ATCGCGCGAT TGATTAAAAA ATTAAGCCAG ATTACTGGAT TGAAACGCAT TAGGATTGGG 660

AGTTTAGAGC CTAATCAAAT CAACGATGAA TTTTTAGAGC TTTTAGAAGA GGATTTTTTA 720

GAAAAACATT TGCATATCGC TTTACAGCAC AGCCATGATT TCATGCTAGA GAGAATGAAT 780

CGAAGAAACC GCACTAAAAG CGATAGGGAA TTATTAGAGA TAATCGCTTC TAAGAATTTT 840

GCTATCGGCA CGGATTTTAT TGTGGGGCAT CCGGGCGAGA GTGAAAGCGT TTTTGAAAAG 900

GCGTTTAAAA ATTTAGAAAG CTTGCCTTTA ACGCATATCC ACCCTTTTAT TTACAGCAAG 960

CGAAAAGACA CCCCCTCTAG TTTGATGCGT GATAGCGTGA GTTTGGAAGA TTCTAAAAAG 1020

CGTTTGAATG CGATTAAAGA TTTGATTTTT CATAAAAATA AGGCGTTCAG GCAATTGCAA 1080

CTCAAACTCA ACACGCCCCT AAAAGCCCTA GTGGAAGCGC AAAAAGACGG CGAATTTAAA 1140

GCCTTAGATC AATTTTTCAA CCCCATTAAA ATCAAAAGCG ATAAGCCTTT AAGGGCTAGT 1200

TTTTTAGAAA TCAAAGAGTA TGAAATTAAG GAGAGGGAAA ATCATGCCGT TTTCTAA 1257

(2) INFORMATION FOR SEQ ID NO: 338:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 528 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular (n) MOLECULE TYPE DNA (genomic)

(ill) HYPOTHETICAL. NO

(iv) ANTI-SENSE. NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...528

(xi) SEQUENCE DESCRIPTION. SEQ ID NO: 338:

TTGAAAATCG CTTACAGGCT TTTAGGTTTG ATGAGCTTTA TCGCGCTTGT CTTAGCGATC 60

GTTTTAATCA GTATCCTGCC CTTACAAAAA ACCGAACACC ATTTCGTGGA TTTTTTAAAC 120

CAGGACAAGC ATTACGCCAT TATCCAAAGA GCGGATAAAA GCATTTCCAG TAATGAAGCG 180

TTGGCTCGTT CGCTCATTGG GGCGTATGTG TTAAACCGAG AGAGCATTAA TCGCATTGAC 240

GATAAATCCC GCTATGAACT GGTGCGCTTG CAAAGCAGCT CTAAAGTGTG GCAACGCTTT 300

GAAGATTTGA TTAAAGCCCA AAACAGCATC TATGTGCAAA GCCATTTAGA AAGAGAAGTC 360

CATATCGTCA ATATTGCGAT CTATCAGCAA GACAATAACC CCATTGCGAG CGTGTCCATT 420

GCGGCTAAAC TTTTGAATGA AAACAAGCTC GTGTATGAAA AGCGTTATAA AATCGTATTG 480

AGCTATTTGT TTGACACCCC GGATTTTGAT TACGCTTCCA TGCCCTAA 528

(2) INFORMATION FOR SEQ ID NO: 339:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 561 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...561

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 339:

TTGTTGCTTG TTTCTCGCTT TTTAAACGCC ATTGATCCTT TTAATTTAGG GGTGTTGTTG 60

AGCCGTTTCC AAATTAAAAA TGGTTGTATT TATGGGGTGT GTTCTTACAA GGTTTCAAAA 120

TTTACCCCTG GATATGAAGA AAGCAAAGCG CGAGTTTTAA ACGCTCTCAA TATTTTAAGC 180

AAGCATCAAA TTTGGCAATC CAATCAAGAA AGCGTTACAA AAGTCAAAGG AACTTTTGTT 240

TTCATTTTAG AAAATGACCT GCATTTAGAC GAAAACTCTT TTTATAAGAA ACTTTTAAAT 300

CTGATTATAG ACAATGACTT TTTTAACCGC TCTCATTTAG TAACTCCGAG CAATGGCACC 360

AACTCCCACC CTGAATTGCA CCGCTCTATC ACGCCCAGAG AAGCCGCTAG GATACAAAGT 420

TTTAGCGATG ATTATATCTT TTATGGCAAT AAAACGAGCG TTTGCAAGCA AATCGGTAAC 480

GCCGTGCCTC CTCTTCTAGC CCTAGCCTTA GGCAAAGCGA TCTTAAAAAG CGCAAGAAAT 540 GATACAAATC CATCACGCTA A 561

(2) INFORMATION FOR SEQ ID NO 340

(l) SEQUENCE CHARACTERISTICS.

(A) LENGTH: 522 base pairs (3) TYPE nucleic acid

(C) STRANDEDNESS- double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE. NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...522

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 340:

ATGGGGTTAA AGAATAAAAT CAAGGGTTTT GTTAAAGAGA GAATGCCTTT TGTAATGAGA 60

TGCGTTCGTG GTTTAAAAGG GGCCAAAGAC ACCCATGAAA ACGCCCATGA TAGGGACGCT 120

TATTGTGGAA TCAATCGTGA AATTAAGGAA ATGCTAGAGG CTAAAAAACT TCATTTTCTT 180

CAAGAAAAAG CTTTATTCAA CCACGACCAT CAAGAAAGCG TGTTTTTAGC TATCGCCTCT 240

TTAAATAATG AAAGTTTCAT TGAATACAAC AAGAGTATTT ATAAAAATAG TTCTCTTAAT 300

TATAATTATG GGGGGCATTT AGAAGATAGG GTCATCCATC CCACTTTAAC TTTACCCAAT 360

CCCACGCATT CGGGTTATTT TGACTATGAT AAAAAAAGTC AAAACCCTAA AAGCCCTCTA 420

AACCCATGGG CTTTTATTAG AGTCAAAAAC GAAATCGTTA CTTTAGAAGA GAGTTTGTTT 480

TCTATGCTTC CTGCCGTTCA AAGGGGGGGT CATTGGTTTT AA 522

(2) INFORMATION FOR SEQ ID NO: 341:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 528 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...528

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 341: TTGTGGCACC AACTCTATCA TTACTGTAAT TATACGCTTT CTTTTATCCC TAAAAATGAG 60

TGGGTAGTAA AAATTGATTG CGATCATATC TATGACGCTA AAAAGCTTTA TAAAAGTTTT 120

TATATTCCTA AGAATATTAA AGAGGTTGTG ATGTATTCGC GCATTAATTT TGTGGTGCGA 180

GATTTTGAAG TGTTTGTTCG TAACGATGGG GATTTTGGGT TTTTAGACGC ATGGGGGGAT 240

CATTGGTTAT TGTATAACGA TTGCGAGCCT TTTGAAATTT GGCGCTACAA TGATGAAAGT 300

TATGAAGTCC TAAAGCTTAA AGATAAACAC CATATTAAAG ATAAGGAAAT GGTGCAATGG 360

CACTTCCCTT TGGCTAAAAA GAGGCGAAAC GCTATTGTTT ATGACGATTT GATCCCTTTA 420

GAAGAATTCA AAAAACGCCA TGCCGATTTG ATAGGCACAA GGATTGAAGA AAGCATGCTA 480

GATGAAAAGA GGATTTTAGA GGTATATCAA AAATTCCGCT TGCCTTAA 528

(2) INFORMATION FOR SEQ ID NO: 342:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1074 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1074

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:342:

ATGCAAAAAC CACAAAATAA ACCCAGCTCA TCGCAACAAT CTCCTCAAAA CTTTTCTTAC 60

CCAGAGTCCA AACTAGGCTC TAAAAACTCT AAAAACAGCC TTTTACAGCC TTTAGTAACT 120

CCTAGCAAAG TAAGCCCCAC TAACGAAGTT AAAACGCCAA CAAACGACGC TAATCCCCCT 180

TTAAAGCATT CTTCACAAGA TCAAGAAAAC AACCTCTTTG TAGCGCCACC CACTGAAAAA 240

ACGCTCCCTA ACAACACCTC TAGTGCTGAT GCGAGTGAAA ACAATGAAAG CAACGAAAAT 300

AGGGATAATG TGGAAAAACA AGCGATTAGA GATCCTAATA TCAAAGAATT CGCATGCGGG 360

AAGTGGGTTT ATGATGATGA AAATTTACAA GCCTATCGCC CAAGCATTTT AAAACGCGTT 420

GATAAAGACA AAGAGATTAC AACAGACATT ACCCCTTGCG ATTACAGCAC CGCTGAAAAT 480

AAAAGCGGTA AAATCATTAC CCCCTATACT AAAATCTCTG TTCATAAAAC AGAGCCTTTA 540

GAAGACCCTC AAACTTTTGA AGCTAAAAAT AATTTCGCCA TTCTCCAAGC CAGAAGCTCT 600

ACAGAAAAGT GTAAAAGGGC TAGAGCGAGA AAAGACGGCA CGACCAGGCA ATGCTATCTG 660

ATAGAAGAGC CTTTAAAACA AGCGTGGGAG AGCGAGTATG AAATCACCAC GCAATTAGTG 720

AAAGCCATAT ATGAACGCCC CAAACAAGAC GATCAAGTAG AGCCGACTTT TTATGAAACC 780

AGCGAATTGG CTTATTCTTC CACACGAAAA AGCGAAATAA CGCGTAATGA ATTGAATTTG 840

AATGAAAAAT TCATGGAATT TGTGGAAGTG TATGAGGGGC ATTATTTAAA CGATATAATC 900

AAAGAGAGCA GCGAATACAA AGAATGGGTT AAAAACCATG TGCGCTTTAA AGAAGGGGTG 960

TGCATGGCCT TAGAAATAGA AGAGCAACCA CGAGCCAAAA GCACGCCTTT GAGTATTGAA 1020

AACTCTCGTG TTGTGTGTGT CAAAAAGGGG AATTATTTAT TCAATGAAGT TTAA 1074

(2) INFORMATION FOR SEQ ID NO: 343:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 432 base pairs (B) TYPE nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY circular

(11) MOLECULE TYPE- DNA (genomic)

(m) HYPOTHETICA . NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...432

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 343:

ATACAATACC CCAAGTCATC TTTTTTTCAA AAAAGGGGTA GGAATGGCAA CCATTCAACC 60

ATTCAACCAT TCAACCATTC AACCATTCAA CCATTCAACC ATTCAATCAT TCAATCATTC 120

AATCATTCAA TCATTCAATC ATTCAATCAT TCAATCATTC AATCATTCAA TCATTCAACC 180

ATTCAAGCAA CGCTACCTTA TTTTTATAAC TATTTATCTT TTTACAAAAA CCTATTTAAA 240

AATCCCCTAT TTTTTATTAT TCCCCCTTTT ATTAACCCTT TTATTAACCC TTTTATTAAC 300

CCTTTTATTA ACCCTTTTAT TAACCCTTTT ATTAACCCTT TTATTAACCC TTTTATTAAC 360

CCTTTTATTA ACCCTTTTAT TAACCCTTTT ATTAACCCTT TTATTAACCC TTTTATTAAC 420

CCTTTCATAT AA 432

(2) INFORMATION FOR SEQ ID NO: 344:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 729 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...729

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 344:

TTGAAAGTCA ATTTCTTTGC CACTTGTCTA GGAGCAGCTA TTTATAGCAA CGCATCGCTT 60

AACGCTATCA AATTACTCCG CAAGGAAAAT TTGGAAGTGG TTTTTAAAAA AGACCAGACA 120

TGTTGTGGCC AGCCAAGCTA CAACTCAGGA TACTATGAAG AGACTAAAAA AGTCGTTTTA 180

TACAATATCA AACTTTATTC CAATAACGAC TACCCTATTA TTTTGCCTAG CGGTTCATGC 240

ACAGGGATGA TGCGGCATGA TTATTTGGAA TTGTTTGAAG GGCATGCGGA ATTTAACATG 300

GTTAAAGATT TTTGCTCTAG GGTGTATGAA TTGAGCGAGT TTTTGGATAA AAAATTGCAA 360 GTCAAATACG AAGATAAGGG CGAACCTCTC AAAATCACAT GGCATTCTAA TTGCCATGCC 420

TTAAGGGTGG CTAAAGTGAT TGACTCGGCG AAAAATCTCA TCAGACAGCT TAAAAATGTG 480

GAACTCATTG AATTGGAAAA AGAAGAAGAA TGCTGCGGGT TTGGGGGGAC TTTTTCAGTT 540

AAAGAGCCTG AAATTTCAGC GGTTATGGTC AAAGAAAAGA TTAAAGACAT AGAGAGCCGT 600

CATGTGGATG TGATCGTTTC AGCGGATGCT GGGTGCTTGA TGAATATCAG CACCGCTATG 660

CAAAAAATGG GCTCTTTGAC AAAACCCATG CATTTTTATG ACTTTTTAGC CTCAAGGCTT 720

GGACTTTAA 729

(2) INFORMATION FOR SEQ ID NO: 345:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1206 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1206

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 345:

ATGATTTTTG GGGATTTTAA ATATCAAAAA AGCGTTAAAA AACTCACAGC CACTAACCTT 60

AACGAGCTTA AAAACGCCCT GGATTTTATC TCTCAAAATA GGGGGAAGGG GTATTTTGTG 120

GGGTATCTTT TGTATGAAGC GCGCTTAGCG TTTTTAGATG AAAATTTTCA AAGCCAAACC 180

CCTTTTTTGT ATTTTGAACA ATTTTTAGAA AGAAAAAAAT ACCCTTTAGA GCCTTTAAAA 240

GAGCATGCGT TTTACCCTAA AATCCACAGC TCTTTAGATC AAAAAACTTA TTTCAAGCAG 300

TTTAAGGCCG TTAAAGAGCA TCTCAAAAAC GGCGATACCT ATCAAGTGAA TTTGACAATG 360

GATTTATTGT TAAACACTAA AGCCAAACCA AAGCGCGTTT TTAAGGAAGT GATACACAAC 420

CAAAACACGC CTTTTAAGGC TTTTATAGAA AATGAGTTTG GGAGCGTTTT AAGCTTTTCG 480

CCGGAATTGT TTTTTGAATT AGAGTTTTTA GACACAGCGA TTAAGATTAT CACAAAACCC 540

ATGAAAGGCA CGATCGCTCG CTCAAACAAC CCCTTGATAG ATGAAAAAAA CCGATTGTTT 600

TTGCAAAATG ATGACAAAAA TAGAAGCGAA AATGTGATGA TCGTGGATTT ATTGCGTAAC 660

GATTTGAGCC GCTTGGCCTT AAAAAATAGC GTGAAAGTCA ATCAATTGTT TGAAATCATC 720

AGTTTGCCGA GCGTGTATCA AATGATAAGC GAGATTGAAG CTCAATTGCC CCTAAAAACA 780

AGCTTGTTTG AGATTTTTAA GGCGTTGTTC CCTTGCGGCT CTGTGACCGG ATGCCCTAAA 840

ATCAAAACCA TGCAAATCAT TGAAAGTTTA GAAAAACGCC CTAGGGGGGT GTATTGTGGG 900

GCGATAGGCA TGGTTGGAGG AAAAAAAGCC CTTTTTAGCG TGCCTATCCG CACTTTAGAA 960

AAAAGAGCGC ATGAAGATTT TTTGCATTTA GGGGTAGGGA GTGGGGTAAC TTATAAAAGT 1020

AAAGCTTCAA AGGAATATGA AGAGAGCTTT TTAAAATCCT TTTTTGTGAT GCCCAAAATA 1080

GAATTTGAGA TCGTGGAAAC GATGAGAGTT ATCAAAAGGG ATCAAAAATT AGAGATTAAC 1140

AATAAAAACG CCCATAAAGA ACGCTTAATG CATAGCGCCC AATATTTTAA CTTTAAATAC 1200

AGATGA 1206

(2) INFORMATION FOR SEQ ID NO: 346:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 795 base pairs (B) TYPE, nucleic acid

(C) STRANDEDNESS double

(D) TOPOLOGY, circular

(11) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL. NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...795

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 346:

ATGAAAATCA GTGTTAGTAA AAACGATTTA GAAAACACTT TGCGCTACTT GCAAGCTTTT 60

TTGGATAAAA AGGACGCTTC CTCTATCGCT TCACACATCC ATTTAGAAGT CATTAAAGAA 120

AAGCTCTTTT TAAAAGCCAG CGATTCAGAT ATTGGACTAA AAAGCTATAT TTCTACGCAA 180

TCTACCGATA AAGAGGGCGT AGGCACGATC AACGGGAAGA AGTTTTTAGA TATTATCTCA 240

TGTTTGAAAG ACTCTAATAT TGTTTTAGAG ACTAAAGATG ACAGCTTGGT GATCAAACAA 300

AATAAAAGCT CTTTCAAACT CCCCATGTTT GACGCTGATG AGTTCCCTGA ATTCCCTGTT 360

ATTGATCCAA AAGTGAGTTT AGAAATCAAT GCCCCCTTTT TGGTGGATGC GTTTAAAAAG 420

ATCGCTCCTG TGATTGAGCA AACTAGCCAT AAAAGGGAAT TAGCCGGTGT TTTAATGCAA 480

TTCAATCAAA AACACCAAAC CCTTTCAGTG GTAGGCACGG ATACCAAGCG GCTCTCTTAC 540

ACGCAGTTAG AAAAAATCTC TATCCATTCC ACCGAAGAAG ACATCTCTTG CATTTTGCCT 600

AAAAGGGCTT TATTGGAAAT CCTTAAACTT TTTTATGAAA ATTTCAGTTT TAAAAGCGAC 660

GGCATGTTAG CGGTGGTTGA AAACGAAACG CACGCTTTTT TCACCAAGCT CATTGATGGG 720

AATTACCCTG ATTATCAAAA AATCCTCCCT AAAGAATACA CTTCTTCTTT CACTTTAGGC 780

AAGGAAGAAT TTTAA 795

(2) INFORMATION FOR SEQ ID NO: 347:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 939 base pairs

(B) TYPE: nucleic acid

( C ) STRANDEDNESS : double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...939

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 347: TTGAATAATT TAGAGCCTTT GGGCGCGGAA GTGTTTGTGG GGTTAGACGG CATTGATGCG 60

ATGATAGAGG AGTGCGTTTC CAATTTAGTC ATTAACGCCA TTGTGGGCGT AGCCGGATTG 120

AAAGCGAGCT TTAAAAGCTT ACAAAGGAAC AAAAAACTAG CCCTAGCGAA TAAAGAAAGT 180

TTAGTGAGCG CGGGGCATTT ATTAGACATT TCACAAATCA CGCCCGTTGA TAGCGAGCAT 240

TTTGGTTTGT GGGCGTTGTT GCAAAACAAG ACTTTAAAGC CTAAATCTTT AATCATTAGC 300

GCGAGTGGGG GGGCTTTTAG GGACACGCCC TTAGATCTTA TCGCTATTCA AAATGCGCAA 360

AACGCGCTCA AGCACCCTAA TTGGAGCATG GGGGATAAAA TCACCATTGA TTCAGCGAGC 420

ATGGTCAATA AACTTTTTGA AATTTTAGAA ACCTATTGGC TTTTTGGTGC GTCTTTAAAG 480

ATTGACGCGC TGATTGAAAG AAGTTCTATC GTGCATGCTT TGGTGGAGTT TGAAGACAAC 540

TCTGTCATTG CGCATTTAGC GAGTGCGGAC ATGCAATTAC CCATAAGCTA TGCCATTAAC 600

CCTAAATTAG CTTCTTTGAG TGCTTCCATT AAACCCTTAG ATTTATACGC TTTAAGCGCG 660

ATTAAATTCG AACCCATTAG CGTGGAGCGC TACACTTTGT GGCGTTATAA AGATTTGTTG 720

TTGGAAAACC CAAAGCTTGG CGTGGTGCTG AATGCGAGCA ATGAAGTGGC GATGAAGAAG 780

TTCTTGAATC AAGAAATCGC TTTTGGTGGC TTTATCCAAA TCATCTCTCA AGCTTTAGAA 840

TTGTATGCTA AAAAATCTTT CAAGCTCTCT AGTTTAGATG AAGTGCTAGC GTTAGATAAG 900

GAAGTTAGGG AGCGTTTTGG AAGTGTAGCG AGAGTGTAG 939

(2) INFORMATION FOR SEQ ID NO: 348:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 873 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...873

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 348:

ATGTTAGAAA ATGTCAAAAA ATCCCTTTTT AGGGTTTTGT GCTTGGGCGC GTTGTGTTTA 60

GGGGGGCTAA TGGCAGAGCA AGACCCTAAA GAGCTTGTCG GTTTGGGGGC AAAGAGCTAC 120

AAAGAGCAGG ATTTCACTCA GGCTAAGAAA TATTTTGAAA AAGCTTGCGA TTTGAAAGAA 180

AATAGCGGGT GTTTTAATTT AGGGGTGCTT TATTATCAAG GGCATGGGGT GGAAAAGAAT 240

TTGAAAAAAG CCGCTTCATT TTACTCTAAA GCTTGCGATT TAAATTACAG CAATGGGTGT 300

CATTTGCTAG GGAATTTATA TTATAGCGGG CAAGGCGTGT CCCAAAACAC CAACAAAGCC 360

TTGCAATACT ACTCTAAAGC GTGCGATTTG AAATACGCTG AAGGGTGTGC GAGCTTAGGG 420

GGGATCTATC ATGATGGCAA AGTGGTTACT AGGGATTTTA AAAAAGCGGT GGAATATTTC 480

ACTAAAGCTT GCGATTTGAA CGATGGCGAT GGTTGCACGA TATTAGGGAG CTTGTATGAT 540

GCAGGCAGAG GCACGCCTAA AGATTTGAAA AAAGCGCTCG CTTCGTATGA TAAAGCTTGC 600

GACTTAAAAG ACAGCCCAGG GTGCTTTAAC GCAGGGAACA TGTATCATCA TGGCGAAGGT 660

GCGGCGAAGA ATTTTAAAGA GGCCCTCGCT CGTTATTCTA AGGCATGCGA GTTGGAAAAT 720

GGCGGAGGGT GTTTCAATTT AGGGGCTATG CAATACAATG GCGAAGGCGC AACAAGGAAT 780

GAAAAGCAAG CCATAGAAAA CTTTAAAAAA GGCTGTAAAT TAGGCGCTAA AGGGGCATGC 840

GATATTCTCA AGCAGCTCAA AATCAAAGTT TAG 873

(2) INFORMATION FOR SEQ ID NO: 349: (l) SEQUENCE CHARACTERISTICS.

(A) LENGTH. 714 base pairs

(B) TYPE, nucleic acid

(C) STRANDEDNESS- double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE- DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...714

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 349:

ATGAAGTCAA ATAAAAAGTC CAATCATTTA AGAGCGATTT ATAGGGCTTT AGTGATCGCT 60

ATAGGCTTAG CCGTTATCAT TGTTTTCAAT TATTTTAACC GCAAAAACAA TAACGCCCGC 120

TCCAGCCGTA GGGCTTGTTC GTGTTTTTTT TCTCTCACCG GGGTTAATTT AGAAAAAATA 180

GGTTCCTTTG ACACGGGCGC TAAACTCATT GTCTTAAACC ACCAAAGCTT ACTAGACATT 240

ATTTATTTAG AAGCCTACCA CCCTAGTAAT ATTTGCTGGA TCGCTAAAAA AGAGCTGGGC 300

GAAATCCCTT TTTATGGGCA TGCTCTAACG GATACCGGAA TGATCTTAAT TGACAGAGAG 360

GATAAAAAGG GGATAGTGAG CCTTTTGAAA GCATGTAAAG AAAAGCTAGA TCAAAACCGC 420

CCTTTAGTGA TTTTTCCTGA AGGCACTAGA GGCAAAGGAG GAGAAAAATT CCTCCCCTTT 480

AAGCAAGGGG CTAAAATCAT CGCTGAAAAA TTCCAGCTCA AAATCCAGCC CATGGTGTTA 540

ATCAATTCCA TTAAAATCTT TAATTCCAAG CCCCTAGAAG CTTATAAAGC GCGCACCCGT 600

TTGGTCATGC TAGAAAGCTA TACGCCTGAT TTTAGCTCGC CCACCTGGTA TGAAGAATTA 660

CAAGAACGCA TGCAAAAAGA ATATTTAAAA CACTACCACG AACTAAACGC ATGA 714

(2) INFORMATION FOR SEQ ID NO: 350:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2046 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi ) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...2046

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 350: ATGGGTTTTG AAAAAAGCAT TTTAGACAAT TTGAACGGAG CGCAAAAAAT TGCCGCATGC 60

CACATTCAAG GGCCTTTATT GATTTTAGCG GGAGCTGGGA GCGGTAAGAC TAAGACTTTA 120

ACGAGCCGTT TAGCGTATTT GATTGGCGCT TGTGGCGTGC CTAGCGAAAA CACTTTAACG 180

CTCACTTTCA CCAATAAAGC GAGTAAAGAA ATGCAAGAAA GGGCTTTGAA ATTGTTGAAA 240

AACCAAGCCC TTATCCCCCC CTTGCTTTGC ACTTTCCATC GTTTTGGTTT GCTGTTTTTA 300

AGGCAACACA TGAATCTTTT AAAAAGGGCG TGCGATTTTT CGGTGCTAGA TAGCGATGAA 360

GTGAAAACGC TCTGCAAACA GCTCAAAATT TCAAATTTCA GGGCGAGCAT TTCTCAAATC 420

AAAAACGGCA TGATGGATTT GAGCGTGCAA GATAGCGAAT GTTACAAAGC GTATGAGCTT 480

TATCAAAACG CGCTCAAAAA AGACAATTTA GTGGATTTTG ACGATTTGCT TTGTTTGAGC 540

CTTAAGATTT TACAAGATAA TGAAAAACTC GCCAAAGAGA CCAGCGAACG CTACCATTAC 600

ATTATGGTAG ATGAGTATCA AGACACGAAC GCCCTGCAAC TGGAATTTTT AAAACAATTG 660

AGTTTCACGC ACCATAATTT GTGCGTGGTG GGCGATGACG ATCAGAGCAT TTATGGGTTT 720

AGGGGGGCTG ATATTTCTAA CATTTTAAAT TTTTCCAAGC ATTTTAAAGG GGCTAAAATA 780

GTGAAATTAG AGACCAACTA CCGCTCTAGC GCTGAAATCT TAGCGTGCGC TAATTCCCTG 840

ATCAGCCATA ACCAACACCG CCACATTAAA ACGCTTCAAA GTTTCAAAGG TTCGCACAAA 900

AGCGTGATTT GTAAAGAATA CCCCACGCAA AAAGAAGAGA GCCTGGATGT GGCTTATCAG 960

ATCAAAGCCC TTTTAAAGAA GGGCGAGAAT TTAGAAAATA TCGCTATTTT GTATCGTTTA 1020

AATGGGCTTA GCCGCAGCAT TGAAGAGAGC TTGAACGCTT TGAATATCCC TTATAGGCTC 1080

ATTGGTGCGG TGAGTTTCTA TGAAAGAGCC GAGGTTAAAG ACGCTTTGGC ACTCATGCAT 1140

GTGGTGGCGA AAAAAGACGA TCGCTTTTTT ATTAAACGCG TTTTAAACAA GCCCCCAAGA 1200

GGCCTTGGCA AGATCACTCA AGAATGGATT TTTTCTCTTT TAGATGAAGA GGGTTTGAAT 1260

TTAGAAGAAG CGCTAAAAAT TGGGGCGTTT AAAGACAAAC TCAACCCTAA AAACGAATAC 1320

GCTTTAAAGA AATTCACCGC TATGATAGGG CGTTTGAGGG AGGCTTTTGA AATTTCAGTA 1380

GAGAAGTTTT GCGAGCGGTT TTTAGAAGAG ACTAACCTTT TAAAAAGCTA TGAAAAAGAA 1440

GACAATTACG AAGAAAGAGA GGGCTTTGTT AAAGAGCTTT TAAGTTTAGT GAAAGAGCAT 1500

TTTAAAACTA ACCCCACGCA TTCTTTACTG GATTTTTTGA ATGAAAGCGC ACTGGATGTC 1560

CATAATACAG AAAACGCGCA AAAAGTGAGT TGCATGAGCG TGCATATGAG TAAGGGCTTA 1620

GAGTTTAAGC ATGTGTTTGT GATCGGGTTA GAAGAGGGGT TTTTCCCGCA TAGGGGGTTC 1680

AATCAAGAAA GCGATTTGGA AGAAGAAAGG CGCTTGGCTT ACGTGGCGAT CACTAGGGCT 1740

AAAGAAGAAT TACAACTTTC TTATGTCAAA GAGCGTTCGT ATTTTGGGAG GAAAATTTCT 1800

TGCTCGCCCT CTGTGTTTTT AGAAGAAGCC CAGTTGCTCC AACAAGACAA GCCTCCTAAA 1860

CAAAATCACC AAAAAGATAC GCCCATTAAA GTGGGGGATT TGATCAAACA TAAGATTTTT 1920

GGCACCGGGA GGGTTTTAGG CGTAGAAAAA GGCTTGAGCG GTTTGTGCTT GAAAATCAAT 1980

TGCGGAGGGA ATGTCTATGA TAAAATTTCA GAAAAATTTG TAGAAAAAGT GGATAACGAG 2040

TTTTGA 2046

(2) INFORMATION FOR SEQ ID NO: 351:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 831 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...831 (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 351:

ATGAAAACTT CTAACACAAA AACCCCTAAA CCCGTTTTAA TCGCCGGGCC ATGCGTCATT 60

GAGAGTTTAG AAAATCTAAG AAGTATCGCT ATTAAATTAC AACCCCTAGC CAACAACGAG 120

CGGTTGGATT TTTATTTTAA AGCGAGTTTT GATAAGGCTA ACCGCACGAG TTTGGAGAGT 180

TACAGAGGAC CTGGTTTAGA AAAAGGCTTA GAAATGTTAC AAACTATCAA AGATGAATTT 240

GGTTATAAAA TTTTAACCGA TGTGCATGAG AGCTATCAAG CAAGCGTGGC AGCCAAGGTA 300

GCGGATATTT TACAAATCCC GGCGTTTTTG TGCCGCCAAA CGGATCTGAT TGTAGAAGTG 360

AGCCAAACTA ACGCCATTGT CAATATCAAA AAAGGGCAAT TCATGAACCC AAAAGACATG 420

CAATATTCCG TTCTAAAAGC CCTTAAAACA AGGGATAGTA GCATTCAAAG CCCCACTTAT 480

GAAACAGCGT TAAAAAATGG CGTGTGGCTG TGTGAAAGGG GGAGCAGCTT TGGGTATGGG 540

AATTTAGTGG TGGATATGCG CTCTTTAAAA ATCATGCGAG AATTTGCCCC TGTGATTTTT 600

GACGCTACCC ATAGCGTGCA AATGCCAGGG GGAGCGAACG GGAAAAGTTC AGGAGACAGC 660

TCTTTTCCCC CTATTTTACC CAGAGCGGCG GCGGCGGTGG GGATTGATGG GCTGTTCGCT 720

GAAACGCATA TTGATCCTAA AAACGCCCTA AGCGATGGAG CAAACATGCT AAAACCTGAC 780

GAGCTAGAAC ACTTAGTAAC CGACATGTTA AAAATCCAAA ATTTATTTTA A 831

(2) INFORMATION FOR SEQ ID NO: 352:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1311 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1311

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:352:

ATGATGAAAT TTTTTCTTTT AAAGAAATTC AGCGAATTTT TAAACACTCA AACGCATTTT 60

AACCTCAAAC GCTTGAACGC GTCTAGTTTT TTATTAGAGA CTTTTTCTAA AGAAAAACAC 120

GCCTTTGTTG TGGATTTGAG CGCGCCTTAT ATTGGTTTGT CCAAAAAACC CCCAGAGAGC 180

GTTTTAAAAA ACACTTTAGC GTTAGATTTT TGTTTGAATA AATTCACCAA AAACGCCAAA 240

ATTTTACAAG CAAACGTCAT TGATAACGAT CGGATTTTAG AAATCAAGGG CGCTAAAGAT 300

TTAGCTTATA AGAGTGAAAC TTTTATTTTG CGTTTAGAAA TGATCCCTAA AAAAGCCAAT 360

CTCATGATTT TAGATCAAGA AAAATGCGTG ATAGAGGCTT TTCGTTTTAA TGACAGGGTG 420

GCTAAAAACG ATATTTTAGG GGCATTGCCT CCTAATATTT ACGAGCATCA AGAAGAGGAT 480

TTGGATTTTA AGGGATTGTT GGACATTTTA GAAAAAGATT TTTTATCCTA TCAGCACAAA 540

GAATTGGAAC ACAAAAAAAA TCAAATCATC AAGCGATTAA ACGCCCAAAA AGAACGCTTG 600

AAAGAAAAAT TAGAAAAACT AGAAGATCCT AAAACTTTAC AGCTGGAAGC GAAAGAATTG 660

CAAACTCAAG CCTCATTGTT GCTCACTTAC CAGCATTTAA TCAACAGGCG TGAAAATCGC 720

GTGATTTTAA AGGATTTTGA AGATAAAGAA TGCATGATTG AAATTGATAA GAGCATGCCC 780

TTAAACGCTT TTATCAATAA AAAATTCACT CTCAGCAAGA AAAAGAAACA AAAATCGCAA 840

TTCTTGTATT TAGAAGAAGA GAATCTGAAA GAAAAAATCG CTTTTAAGGA AAATCAAATC 900

AACTATGTTA GAGACGCTGC AGAAGAAAGC GTTTTAGAAA TGTTTATGCC GGTAAAAAAC 960 TCTAAAATCA AACGCCCGAT GAACGGGTAT GAAGTGCTGT ATTATAAGGA TTTTAAAATC 1020

GGTTTAGGGA AAAACCAAAA AGAGAATATC AAGCTTTTAC AAGACGCAAG AGCGAATGAT 1080

TTGTGGATGC ATGTGAGAGA TATTCCTGGA TCGCATTTGA TCGTTTTTTG CCAAAAGAAT 1140

ACGCCTAAAG ATGAGGTCAT TATGGAATTA GCCAAAATGT TGATTAAAAT GCAAAAAGAT 1200

GCGTTTAATG GTTACGAGAT TGACTACACG CAACGAAAAT TTGTCAAAAT CATCAAAGGA 1260

GCTCATGTCA TTTACTCAAA ATACCGAACT ATTAGTCTAA AGGACACTTA A 1311

(2) INFORMATION FOR SEQ ID NO: 353:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 696 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...696

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 353:

ATGTTTAAAA AAATCATTTT TTTGTGCGTT TTTTTGATAG GGGGATTTGT CATTCCACCC 60

CTTGAAGCCA TGCCTATTTT GCGCAATAAA ACCCCCAAAA AAAATTACCA AGAAGCCCAT 120

GAAAAGCTCT ATAGAAGCAT CATTAACCGC CAAAAGCTCA CGCGTAAAAA AAGCGGGTGG 180

TATTTTTTAG GGGGGGTTGG CGCTGTAGAA GCCATTAAGG ACTATCAAGG CAAGGAAATG 240

AAAGATTGGA TCGCCACGCT CAATTTAAAA ACCGGCGTGC AAAGTTTTTT TAAAAAATAC 300

ATCGGGATTA GGGGGGTTTT TGCATGGGAT CTTGGGTCAG GAAAAGTGAA TTATCAAAGC 360

TATAAAGATC CTACCAACTC TTTTTTTACC ATGCTTGCGG TGGGTTTGGA TGTGATCATG 420

GAATTTCCTC TAGGGAGTTA TAAGCATTAT TTAGGGGCGT TTGGGGGAGC TAGGGGGGCT 480

TTAGTTGTTT ATACAGACAA GCAAAATTTC AAGTTTTTTA AACATTCTGT GGTTTCAGGG 540

GGATTAGCGA TTAGTGGAGG GGTCATGCTC ACGCTTTTTT TAAGGCACCG CATTGAATTA 600

GGGTTTAAGA TCTTGCCCAC CGCCAGATTG CTTTCTAGCT CTAGTCGCTT TGAAACTTCG 660

CCCCTATTTT ATGCGGCATA CAGCTATAAA TTTTAA 696

(2) INFORMATION FOR SEQ ID NO: 354:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1983 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...1983

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 354:

ATGCTAAAAA AGATTTTTTA TGGTTTTATC GTTTTATTTT TGATTATCGT AGGGTTGTTG 60

GCCGTTCTTG TCGCTCAAGT TTGGGTAACT ACGGATAAGG ATATTGCTAA AATTAAAGAT 120

TATCGCCCCA GTGTCGCTTC ACAGATTTTA GACAGAAAAG GGCGTTTGAT CGCTAATATT 180

TATGATAAGG AATTTCGTTT TTATGCGCGT TTTGAAGAAA TCCCCCCACG ATTTGTTGAA 240

AGCCTTCTAG CGGTAGAAGA CACCCTCTTT TTTGAGCATG GGGGGATCAA TTTAGACGCT 300

GTCATGCGCG CTATGATTAA AAACGCTAAA AGTGGTCGTT ACACTGAAGG GGGTAGCACT 360

CTAACCCAAC AACTCGTTAA AAACATGGTG CTCACACGGG AAAAAACCCT AACCAGAAAA 420

CTCAAAGAAG CTATCATCTC CATACGCATT GAAAAAGTCT TAAGCAAAGA AGAAATTTTA 480

GAGCGTTATT TGAACCAAAC TTTTTTTGGG CATGGGTATT ATGGCGTGAA AACCGCAAGT 540

TTAGGGTATT TTAAAAAACC CCTTGACAAA CTCACGCTTA AAGAAATCAC CATGTTAGTC 600

GCCTTACCTA GGGCTCCAAG TTTTTATGAC CCTACCAAAA ATTTAGAATT TTCACTCTCT 660

AGGGCTAATG ATATTTTAAG GCGGTTGTAT TCTTTAGGCT GGATTTCTTC TAACGAGCTC 720

AAATCCGCTC TCAATGAAGT GCCAATCGTC TATAACCAAA CTTCCACGCA AAATATCGCT 780

CCCTATGTCG TGGATGAAGT GTTGAAGCAA TTGGATCAAT TAGACGGGTT AAAAACTCAA 840

GGCTATACCA TAAAACTCAC GATAGATTTG GATTACCAAC GCTTAGCGTT GGAGTCTTTG 900

CGTTTTGGGC ATCAAAAAAT CTTAGAAAAA ATCGCTAAAG AGAAGCCAAA AACTAACGCT 960

TCTAATGATA AAGATGAAGA CAACTTAAAC GCCAGCATGA TAGTTACAGA AACGAGCACC 1020

GGTAAGATTT TAGCCTTAGT GGGGGGGATT GATTATAAAA AAAGCGCTTT CAATCGCGCC 1080

ACGCAAGCCA AACGGCAGTT TGGGAGCGCG ATCAAGCCTT TTGTGTATCA AATCGCTTTT 1140

GATAATGGCT ATTCCACCAC TTCCAAAATC CCTGATACCG CGCGAAATTT TGAAAATGGC 1200

AATTATAGTA AAAACAGCGT GCAAAACCAC GCATGGCACC CTAGCAATTA TACTCGCAAA 1260

TTTTTAGGGC TTGTAACCTT GCAAGAAGCC TTGAGCCATT CGTTAAATCT GGCTACGATT 1320

AATTTAAGCG ATCAGCTTGG CTTTGAAAAA ATTTATCAAT CTTTAAGCGA CATGGGGTTT 1380

AAAAACCTCC CTAAAGATTT GTCTATTGTG TTAGGGAGCT TTGCTATCTC ACCGATTGAT 1440

GCGGCTGAAA AGTATTCTCT ATTTTCTAAT TACGGCACCA TGCTCAAACC CATGCTCATT 1500

GAAAGCATCA CCAACCAACA AAACGAAGTC AAAACTTTCA CGCCCATTGA AACCAAAAAG 1560

ATCACTTCCA AAGAACAAGC TTTTTTAACC CTTTCAGCGC TGATGGATGC GGTAGAAAAC 1620

GGCACAGGGA GTTTGGCTCG CATTAAAGGT TTAGAAATTG CCGGTAAAAC CGGGACTTCT 1680

AACAACAATA TTGACGCTTG GTTCATTGGC TTTACCCCCA CCTTACAAAG CGTGATCTGG 1740

TTTGGGAGAG ACGATAACAC GCCTATTGGC AAAGGAGCGA CAGGAGGCGT TGTGAGCGCG 1800

CCTGTGTATT CGTATTTCAT GCGCAATATC TTAGCGATTG AACCTTCTTT AAAAAGAAAG 1860

TTTGATGTCC CCAAAGGCTT GCGTAAAGAA ATCGTGGATA AAATCCCCTA CTACTCAAGC 1920

CCTAATTCCA TCACCCCCAC CCCCAAAAAA ACAGACGATA GCGAAGAACG CTTGTTGTTC 1980

TAA 1983

(2) INFORMATION FOR SEQ ID NO: 355:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 972 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature (3) LOCATION 1...972

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 355:

ATGAAATATT TATGGCTTTT TTTAATATAC GCTATAGGGC TTTTTGCAAC AGATAAAACG 60

CTAGATATTA TTAAAACCAT TCAAAAACTT CCTAAGATTG AAGTGCGCTA CTCCATAGAT 120

AACGATGCCA ATTACGCTTT AAAATTGCAT GAAGTCTTAG CGAACGATTT AAAGACTAGC 180

CAGCATTTTG ATGTTTCTCA AAACAAAGAG CAAGGTGCTA TCAATTACGC AGAACTCAAG 240

GATAAAAAAG TCCATCTTGT AGCGCTTGTG AGCGTGGCGG TAGAAAACGG CAATAAAATT 300

TCACGATTAA AACTTTATGA TGTGGATACA GGAACGCTCA AAAAGACTTT TGACTACCCC 360

ATTGTAAGTT TAGATCTATA CCCTTTTGCA GCGCACAACA TGGCCATTGT GGTGAATGAT 420

TATTTAAAAG CCCCTTCTAT CGCTTGGATG AAGCGCCTGA TTGTTTTTTC TAAATACATT 480

GGACCAGGAA TCACAAACAT CGCACTAGCG GATTATACGA TGCGTTATCA AAAAGAAATC 540

ATCAAAAACA ACCGACTCAA TATTTTCCCC AAATGGGCGA ACGCTGAGCA AACGGAGTTT 600

TATTACACGC AGTATGGCGA AAAAACGCCC ATGATTTTAA AATACAACAT TCAAAAAGCC 660

ACTCATGAGA ATATCGCTAG CTCTCAAGGA ATGGCTGTGG TCTCTAGCGT GAGTTCTGAT 720

GGCTCTAAAA TTTTAATGTC TTTAGCCCCT GATGGCCAAC CGGATGTTTA TTTGTATGAC 780

ACGCATAAAA AAACTAAAAC CAAAATAACG CGCTATCCGG GGATAGATGT TTCAGGCGTG 840

TTTTTAGAAG ATGACAAGTC TATGGCTTTT GTTTCAGATA GATCCGGTTA TCCTAACATC 900

TATATGAAGA AATTGGGGTT AAAAGAGAGC GCGGAGCAAC TCCTTTATGA AGGAAGAAGC 960

AATGAATCCA TT 972

(2) INFORMATION FOR SEQ ID NO: 356:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3867 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...3867

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 356:

ATGGAAATAC AACAAACACA CCGCAAAATC AATCGCCCTT TAGTTTCTCT CGTTTTAGCA 60

GGAGCGTTGA TTAGCGCCAT ACCGCAAGAG AGTCATGCCG CCTTTTTCAC GACCGTGATC 120

ATTCCAGCCA TTGTTGGGGG TATCGCCACA GGCACTGCTG TAGGAACGGT CTCAGGGCTT 180

CTTAGTTGGG GACTCAAACA AGCCGAAGAA GCGAATAAAA CCCCAGATAA ACCCGATAAA 240

GTTTGGCGCA TTCAAGCAGG AAAAGGCTTT AATGAATTTC CTAACAAGGA ATACGACTTA 300

TACAAATCCC TTTTATCCAG TAAGATTGAT GGAGGTTGGG ACTGGGGGAA CGCCGCTAGG 360 CATTATTGGG TCAAAGGCGG GCAATGGAAC AAGCTTGAAG TGGATATGAA AGACGCTGTA 420

GGGACTTATA AACTATCAGG GCTTAGAAAC TTTACTGGTG GGGATTTAGA CGTGAATATG 480

CAAAAAGCCA CTTTGCGTTT GGGCCAATTC AATGGCAATT CTTTCACAAG CTATAAGGAT 540

AGCGCTGATC GCACCACGAG AGTGAATTTC AACGCTAAAA ATATTTCAAT TGATAATTTT 600

GTAGAAATCA ATAATCGTGT GGGTTCTGGA GCCGGGAGAA AAGCCAGCTC TACGGTTTTG 660

ACTTTGCAAG CTTCAGAAGG GATCACTAGC AGTAAAAATG CGGAAATTTC TCTTTATGAT 720

GGCGCCACGC TCAATTTGGC TTCAAACAGC GTTAAATTAA ATGGTAATGT GTGGATGGGC 780

CGTTTGCAAT ACGTGGGAGC GTATTTAGCC CCTTCATACA GCACGATCAA CACTTCAAAA 840

GTTCAAGGGG AAGTGGATTT TAACCATCTC ACTGTGGGGG ATCAAAACGC CGCTCAAGCG 900

GGCATTATCG CTAGCAATAA GACTCATATT GGCACACTGG ATTTGTGGCA AAGCGCCGGG 960

TTAAATATCA TTGCCCCTCC AGAAGGTGGC TACAAGGATA AACCTAATAG TACCACTTCT 1020

CAAAGTGGCA CTAAAAACGA CAAGAAAGAG ATCAGTCAAA ATAACAATAG CAACACAGAG 1080

GTCATTAACC CACCCAATAA CACGCAAAAA ACAGAAACTG AACCCACGCA AGTCATTGAT 1140

GGGCCTTTTG CTGGCGGCAA AGACACGGTT GTCAATATTT TCCACTTAAA CACTAAAGCC 1200

GATGGCACGA TTAAAGTGGG AGGGTTTAAA GCTTCTCTTA CCACGAATGC GGCTCATTTG 1260

AATATCGGCA AAGGCGGTGT CAATCTGTCC AATCAAGCGA GCGGGCGCAC CCTTTTAGTG 1320

GAAAATCTAA CCGGGAATAT CACCGTTGAT GGGCCTTTAA GAGTGAATAA TCAAGTGGGT 1380

GGCTATGCTT TGGCAGGATC AAGCGCGAAT TTTGAGTTTA AGGCTGGTGT GGATACTAAA 1440

AACGGCACAG CCACTTTCAA TAACGAT TT AGTTTGGGAA GATTTGTGAA TTTAAAGGTG 1500

GATGCTCATA CAGCTAATTT TAAAGGTATT GATACGGGTA ATGGTGGTTT CAACACCTTA 1560

GATTTTAGTG GTGTTACAGA CAAAGTCAAT ATCAACAAGC TCATCACAGC TTCCACTAAT 1620

GTGGCCGTTA AAAACTTCAA CATTAATGAA TTGATTGTTA AAACCAATGG GATAAGTGTG 1680

GGGGAATACA CTCATTTTAG CGAAGATATA GGCAGTCAAT CGCGTATCAA TACCGTGCGT 1740

TTGGAAACTG GCACTAGGTC AATCTTTTCT GGGGGTGTCA AATTTAAAAG CGGTGAAAAA 1800

CTAGTTATCA ATGATTTTTA CTATAGCCCT TGGAATTATT TTGACGCTAG GAATGTTAAA 1860

AATGTTGAAA TCACCAGAAA ATTCGCTTCT TCAACCCCAG AAAACCCTTG GGGCACATCA 1920

AAGCTCATGT TTAATAATCT AACCTTGGGT CAAAATGCGG TCATGGACTA TAGTCAATTT 1980

TCAAATTTAA CCATTCAGGG GGATTTTATC AACAATCAAG GCACTATCAA CTATCTGGTC 2040

CGAGGCGGGA AAGTGGCAAC CTTAAATGTA GGCAATGCAG CAGCTATGAT GTTTAATAAT 2100

GATATAGACA GCGCGACCGG ATTTTACAAA CCGCTCATCA AGATTAACAG CGCTCAAGAT 2160

CTCATTAAAA ATACAGAGCA TGTTTTATTG AAAGCGAAAA TCATTGGTTA TGGTAATGTT 2220

TCTACAGGTA CCAATGGCAT TAGTAATGTT AATCTAGAAG AGCAATTCAA AGAGCGCCTA 2280

GCCCTTTATA ACAATAATAA CCGCATGGAT ACTTGTGTGG TGCGAAATAC TGATGACATT 2340

AAAGCATGCG GTATGGCTAT CGGCAATCAA AGCATGGTGA ACAACCCTGA CAATTACAAG 2400

TATCTTATCG GTAAGGCATG GAGAAATATA GGCATCAGTA AAACGGCTAA CGGCTCTAAA 2460

ATTTCGGTGT ATTATTTAGG CAATTCTACG CCTACTGAGA ATGGTGGCAA TACCACCAAC 2520

TTACCCACAA ACACCACTAA TAATGCGCAT TCTGCTAACT ACGCTCTCGT GAAGAACGCT 2580

CCTTTCGCTC ACAGCGCCAC TCCTAATTTA GTCGCTATCA ATCAGCATGA TTTTGGCACT 2640

ATTGAGAGCG TGTTTGAATT GGCTAACCGC TCTAAAGATA TTGACACGCT CTATACTCAT 2700

TCAGGCGCGC AAGGCAGGGA TCTCTTGCAA ACTTTATTGA TTGATAGCCA TGATGCGGGT 2760

TATGCCAGAC AAATGATTGA TAACACAAGC ACCGGTGAAA TCACCAAGCA ATTGAATGCG 2820

GCCACTGACG CTTTAAACAA CGTAGCCAGT TTAGAGCATA AACAAAGCGG CTTACAAACC 2880

TTGAGCTTGA GTAATGCGAT GATTTTAAAT TCTCGTTTAG TCAATCTCTC TAGGAAGCAC 2940

ACCAACCATA TTAACTCGTT CGCTCAACGC TTACAAGCTT TAAAAGGCCA AGAATTCGCT 3000

TCTTTAGAGA GCGCGGCAGA AGTGTTGTAT CAATTTGCCC CTAAATATGA AAAACCTACC 3060

AATGTTTGGG CTAACGCTAT TGGGGGAGCG AGCTTGAATA GCGGCTCTAA CGCTTCATTG 3120

TATGGCACAA GCGCCGGCGT AGACGCTTTC CTTAACGGGA ATGTGGAAGC CATTGTGGGC 3180

GGTTTTGGAA GCTATGGTTA TAGCTCCTTT AGCAATCAAG CGAACTCTCT TAACTCTGGG 3240

GCCAATAACG CTAATTTTGG CGTGTATAGC CGTTTTTTTG CCAACCAGCA TGAATTTGAC 3300

TTTGAAGCTC AAGGGGCGCT AGGGAGCGAT CAATCAAGCT TGAATTTCAA AAGCACTCTA 3360

TTACAAGATT TGAATCAAAG CTATAATTAC TTAGCCTATA GCGCCACAGC AAGAGCGAGT 3420

TATGGTTATG ACTTCGCGTT TTTTAGGAAC GCTTTAGTGT TAAAACCAAG CGTGGGCGTG 3480

AGCTATAACC ATTTAGGTTC AACCAACTTT AAAAGCAATA GCCAATCACA AGTGGCTTTA 3540

AAAAATGGCG CGAGCAGTCA GCATTTATTC AACGCTAACG CTAACGTGGA AGCGCGTTAT 3600

TATTATGGGG ACACTTCATA CTTTTATTTG CATGCGGGAG TTTTACAAGA GTTCGCTCAC 3660

TTTGGATCGA ATGATGTGGC GTCTTTAAAC ACCTTTAAAA TCAATGCCGC TCGCAGTCCT 3720

TTAAGCACCT ATGCAAGAGC GATGATGGGT GGGGAATTGC AATTGGCTAA AGAAGTGTTT 3780 TTGAATTTGG GCGTGGTTTA TTTGCACAAT TTGATTTCCA ACGCAAGCCA TTTCGCTTCC 3340 AATTTAGGAA TGAGGTATAG TTTCTAA 3867

(2) INFORMATION FOR SEQ ID NO: 357:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1158 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1158

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 357:

ATGAAAGATA GTTTTCTTTT CACTTCCGAA TCAGTAACCG AAGGGCATCC TGATAAAATG 60

GCCGATCAGA TCAGCGATGC GGTTTTAGAT TACATTATTG AGCGGGATAA AAAAGCCAAA 120

GTCGCATGCG AGACTTTAGT TTCTAATGGT TTTTGCATGA TCACTGGCGA GTTAAAAACT 180

TCTGTTTATG CCCCGATGCA AGAGATCGCA AGAGAAGTGG TTAAAAAAAT TGGCTATACA 240

GACGCTCTTT ATGGCTTTGA TTACAGAAGC GCGGCGGTTT TAAATGGCAT TGGCGAGCAA 300

AGCCCTGATA TTAATCAAGG CGTGGATAGA GAAGATGGCG AGATTGGGGC GGGGGATCAA 360

GGGCTTATGT TTGGTTATGC ATGCAAAGAG ACTGAAACGC TCATGCCTTT ACCCATCCAT 420

TTAGCGCACC AGCTCGCTTT CGCTCTAGCT CAAAAAAGAA AAGACAACAC CTTGCCTTTT 480

TTAAGGCCTG ATGGCAAGTC TCAAGTGAGC GTGCGTTATG AAAACAACAA GCCTGTAAGC 540

GTTGATACGA TTGTCATTTC CACCCAACAT TCCCCAGAAG TTTCACAAAA GCATTTAAAA 600

GAAGCGGTGA TTGAAGAGAT CGTGTATAAG GTTTTACCCA AAGAATATTT GCATGACAAT 660

ATCAAGTTTT TTATAAACCC TACAGGAAAA TTCGTCATCG GTGGGCCTCA AGGCGATGCG 720

GGTTTGACAG GTAGAAAAAT CATCGTGGAT ACTTATGGAG GGTTTTGCCC GCATGGAGGG 780

GGAGCGTTTA GCGGGAAAGA CCCTAGCAAG GTGGATAGGA GCGCGGCTTA TGCGGCCCGC 840

TATGTGGCTA AAAATTTGGT AGCGAGCGGG GTTTGCGATA AAGCGACCGT GCAGCTTGCT 900

TATGCGATTG GGGTGATAGA GCCTGTGTCT ATTTATGTGA ACACGCATAA CACGAGCAAG 960

CATTCAAGCG CGGAGTTGGA AAAATGCGTG AAATCGGTTT TCAAACTCAC GCCAAAAGGC 1020

ATCATTGAAA GCTTGGATTT GTTAAGACCC ATTTATTCGC TCACTTCAGC TTATGGGCAT 1080

TTTGGGCGCG AGTTAGAAGA ATTCACTTGG GAAAAGACTA ACAAGGTTGA AGAGATTAAA 1140

GCGTTCTTTA AGCGTTAA 1158

(2) INFORMATION FOR SEQ ID NO: 358:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 207 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...207

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 358:

ATGAAATTTT TAAACGGATT AGCAGGGAAT TTACTGATTG TGGTTATCTT ATTGTGTGTG 60

GTCGTTTTTT TCGCGCTCAA AGCGATCCAT ATCCAAAAAG AGCAAGCCAC CAATTATTAC 120

CGCTATAAGG ATATTAACGC TTTAGAGGCA AAAAACACCC AAAACCACGC TAATTATGAA 180

TTAGTCAATC AAGGGAGTAA AAAATGA 207

(2) INFORMATION FOR SEQ ID NO: 359:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1509 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1509

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 359:

TTGAAAATCT TTTTAGTTAT TCTAAGCGTC TTTTTTTTTA ATGGGTGTTT TGGGCTAGTC 60

TATAAGACTC CCATTTCAAA CCCCCCTATC TCTTATGACC CCTACACTAC CACCATTGGG 120

AGCTTGTATG CTAAAAATTT AAAAGAAAAC CCTAAACATA GTGCGGCCAT TCTTTTAGAA 180

GACGGCTTTG ATGCCTTGTT GCACAGAGTG GGTCTTATTA GAATGAGCCA AAAAAGCATT 240

GACATGCAAA CTTATATCTA TAAAAACGAC CTTTCTTCTC AAGTGATCGC TAAAGAACTT 300

TTAAACGCGG CCAATCGTGG GGTAAAAGTG CGCATCCTTT TAGATGACAA CGGGTTAGAT 360

TCAGATTTTT CAGACATCAT GCTTTTAAAT TTCCACAAAA ACATTGAAGT GAAAATCTTT 420

AACCCCTACT ATATCCGCAA TAAAGGCTTG CGTTATTTTG AAATGCTTGC GGATTATGAA 480

CGCATTAAAA AACGCATGCA CAACAAGCTT TTCATCGTGG ATAATTTCGC TGTCATTATA 540

GGGGGGCGCA ACATTGGGGA CAATTATTTT GATAACGATT TAGACACGAA TTTTTTAGAT 600

TTAGACGCTT TGTTTTTTGG GGGGGTTGCT TCAAAGGCCA AAGAAAGCTT TGAAAATTAT 660

TGGCGATTCC ACCGCTCTAT CCCTGTTTCA TTATTAAGAA CCCATAAAAG ACTCAAAAAC 720

AACGTTAAAG AAATCGCTAA GCTCCATGAA AAAATCCCTA TCAGCGCTGA AGACGCAAAC 780

GAATTTGAAA AAAAAGTCAA TGATTTTATA GAACGCTTCC AAAAATACCA ATACCCCATT 840

TATTATGGGA ATGCCATTTT TCTAGCCGAT TTGCCCGCCA AAATTGACAC GCCCTTGTAT 900

TCGCCCATCA AAATCGCTTT TGAAAAAGCC CTTAAAAACG CTAAAGACTC CGTTTTTATC 960 GCTTCATCGT ATTTTATTCC AGGTAAAAAG ATAATGAAAA TCTTTAAAAA TCAAATTTCT 1020

AAGGGGATTG AATTGAATAT TCTTACCAAT TCCCTTTCAT CTACGGACGC TATCGTGGTC 1080

TATGGGGCGT GGGAAAGGTA TCGCAATAAA TTAGTGCGAA TGGGCGCGAA TGTCTATGAA 1140

ATACGAAACG ATTTTTTCAA CCGCCAGATT AAAGGGCGCT TTAGCACCAA ACATTCCTTA 1200

CACGGCAAGA CAATTGTTTT TGACGATGCC CTAACGCTTC TAGGGAGTTT TAATATTGAT 1260

CCGCGCTCTG CATATATTAA CACTGAAAGT GCGGTCTTGT TTGACAACCC GTCTTTTGCC 1320

AAAAGGGTGC GTTTGTCGCT TAAAGATCAT GCCCAACAAT CATGGCATTT AGTCTTGTAT 1380

CGGCATAGAG TGATTTGGGA AGCTACAGAA GAAGGCATCT TAATCCATGA AAAAAACTCG 1440

CCTGATACCT CTTTCTTTTT GCGTTTGATT AAAGAATGGT CTAAAGTCCT TCCTGAAAGA 1500

GAACTTTAA 1509

(2) INFORMATION FOR SEQ ID NO: 360:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 534 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...534

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 360:

ATGCGTTTTA GTTACATTGA GCCAAGAGCG AAATACTTAA TCAGCAAGCT TTCTAAAATT 60

TGGGTTTTTT ACATTTTTTT ATCTTTTGTG CTAATAGGGG GGTTAGTGTG GTTTATGCAC 120

AACGCCATTA AACGCGCTCA AGACAACGCG TCTAGTTTGA CGATCCAAGA AAGGCTTTAC 180

CGCCATGAAA TCAGCCGCTT GCAGGTAAAG ACTGATGAAA CTTTAAAACT CATTAAAGAA 240

GCCAAAAAGC GTTTGAATTA TAACGATGAT ATACGAGATG TTTTGCAAGG GCTTTTGAAT 300

ATTGTGCCGG ATCTTATCAC CATTAATAGC ATTGAAATAG ACCAACAAAG CGTGGTGGTT 360

AGCGGTAAAA CCCCCTCTAA AGAAGCCTTT TACTTTTTGT TTCAAAACAA ACTAAACCCC 420

ATGTTTGATT ATTCTAGGGC GGAATTTTTC CCTTTAAGCG ACGGGTGGTT TAATTTTGTC 480

TCCACCAACT TTTCTAATTC CTTACTGATA AAAAACCCGG AGTCTATTAA ATGA 534

(2) INFORMATION FOR SEQ ID NO: 361:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 669 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi ) ORIGINAL SOURCE

(A) ORGANISM. Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY mιsc_feature (3) LOCATION 1...669

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 361:

ATGCGTAAGA TCTTGTTAAT GGGCTTGATT TTACAAGCGC TCTTTGGCGA AGAAGCCGCG 60

CAAGAATTGT TGCAATGCTC TGCGATTTTT GAATCTAAAA AAGCCGAATT GAAAGAGGAT 120

TTGCGCCAAT TGAGTGAAAA AGAGCAGTCT TTGAGGATCT TGCAAACCGA AAACGCCCGC 180

CTTTTAGATG AAAAAAGCGA TCTGTTAAAC AAGAAAGAAA AAGAAATAGA CGAAAAACTG 240

AAAAATTTAG CCGCTAAAGA AGAAGCCTTT AAAACCTTAC AAACAGAAGA AAAAAAACGC 300

CTTAAAAATT TGATAGAAGA AAATGAAGGC ATTTTAAGAG AAATCAAGCA GGCTAAAGAC 360

AGCAAGATTG GCGAGACTTA TTCTAAAATG AAAGATTCTA AATCGGCTCT GATTTTAGAA 420

AATTTACCCA CTCAAAACGC TTTAGAAATT TTAATGGCGC TAAAGCCTCA AGAATTAGGC 480

AAAATTCTAG CCAAAATGGA TCCTAAAAAA GCGGCGGCTT TGACAGAGTT GTGGCAAAAA 540

CCCCCAAAAG AAAATAAAGA AAATAAAGAA AGCCAAAAAA CCACAGATCC CACGCCCCCC 600

ACACCACCCA CGCCTCCTAA AGAGCCAACC CTAAAAGATC CTAATGTAAA AGAGCCAACA 660

GGGGTATGA 669

(2) INFORMATION FOR SEQ ID NO: 362:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1296 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...1296

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 362:

ATGAATATTC AAACAAAGAA AAGATTTTTA GCAAATTTAT TGCTTTTTAG CCTGTTTTCT 60

TGCCTTAAGG CTGAAACCCT TTCAGAAGAC CATCAAATCC TGTTGAGTTC AGACGCTTTC 120

CATAGAGGGG ATTTTGCCAC CGCTCAAAAA GGCTATATGA ATCTCTATAA GCAAACCAAT 180

AAAGTGGTGT ATGCTAAAGA GGCGGCCATT TCAGCGGCGA GTTTAGGGGA CATTAAAACC 240

GCTATGCATT TAGCCATGCT TTATCAAAAA ATCACCAATA ATCGTAACGA TGTTTCTATC 300

AATAAGATTT TAGTGGATGG CTATGCACAA ATGGGGCAGA TTGATAAGGC GATTGAACTA 360

TTACACAAGA TTCGTAAGGA AGAAAAAACC ATAGCCACAG ACAATGTGTT AGGGACTTTG 420

TATTTGACTC AAAAGCGTTT GGATAAGGCT TTCCCGTTGT TGAATAAGTT TTATAACCAA 480

GTGCATGATG AAGACAGCCT AGAAAAACTC ATTACGATCT ATTTTTTACA AAACCGCAAA 540

AAAGAGGGTT TGGATCTGTT GCAATCTCAT ATAGACAGGT ATGGTTGCTC AGAGCAATTG 600

TGCCAAAAAG CGCTCAACAC CTTCACGCAA TTTAACGAGC TTGATTTGGC TAAAACGACT 660 TTCGCTCGTT TGTATGAAAA AAACCCTATT GTTCAAAACG CCCAATTTTA CATAGGGGTA 720

TTAATCTTGT TAAAAGAGTT TGATAAGGCC CAGCAAATCG CAGAATTATT CCCCTTTGAC 780

AGGCGTTTGT TGCTAGACTT ATACACCGCG CAAAAAAAAT TTGATCAAGC TTCCAAACAG 840

GCTTCTTTAA TCTATCAAGA AAGAAAAGAC CCTAAATTCT TAGGCTTA.GA GGCGATTTAT 900

CATTATGAAA GCTTGAGCGC GAATAAGAAA AAGCTCACCA AAGAAGAGAT GTTGCCCATC 960

ATTCAAAAAT TAGAGCAAGC CACCAAAGAG CGCCAAGCAT GGCTTGCTAA AACTAAAGAT 1020

AAAGAAGACG CGCAAGACGC TTTCTTTTAT AATTTTTTAG GGTATTCCTT AATAGATTAT 1080

GACATGGATG TTAAAAGGGG CATGGATCTT GTGAGGAAAG CCTTAGCGTT AGATTCTAAC 1140

TCAGTGCTTT ATTTGGATTC TTTAGCATGG GGTTATTACA AATTAGGGAA TTGTTTGGAG 1200

GCTAAAAAAA TCTTTTCTAG CATCGCTAAA GAGCTTATCC AAAACGAACC CGAATTGAAA 1260

GAACACAATA AAATCATTCA AGAATGCAAG AAATAG 1296

(2) INFORMATION FOR SEQ ID NO: 363:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 294 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...294

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 363:

ATGCTTTATG CATCAAAAGC GCGTTTATTT TTACAAATCA AAGGAAAGTT TATGTTAAGA 60

ATTTTAATCC CCTTACTCAT TATTGTGTGG GTTTTATGGC GTTTGTTTTT GAGGCAAAAA 120

CCCCACAAAG ATGACCACAG AGACAACCAC TCTTACACGC AACAAACCCC CAAAGAATTA 180

GAAGATCACA TGATTGTATG CTCTAAATGC CAAACTTATG TCTCTAGTAA AGACGCCATT 240

TATAGTGGGG CGGTAGCCTA TTGCAGTGAA ACTTGTTTGA AGGATAAGGG GTAA 294

(2) INFORMATION FOR SEQ ID NO: 364:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1440 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori ( ix ) FEATURE :

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1440

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 364:

ATGAAAAATA GCGCGCCTTT AAAGAATAAA GTTTTTTGTG GGTTATACGT TTTAAGTTTA 60

AGCGCTTCTG TGCAAGCGTT TGATTATAAA ATTGAAGTTT TGGCAGAGTC CTTTTCTAAA 120

GTTGGCTTTA ATAAAAAAAA GATTGACATA GCTAGGGGGA TTTATCCTAC AGAGACTTTT 180

GTAACCGCTG TGGGTCAGGG CAATATTTAT GCGGATTTTT TATCCAAAAG CCTTAAAGAT 240

CAAGGGCATG TTTTAGAGGG AAAAGTCGGC GGCACAATCG GTGGGATTGC TTATGACAGC 300

ACGAAATTCA ATCAAGGCGG ATCGGTTATT TATAATTATA TCGGTTATTG GGATGGCTAT 360

TTAGGGGGTA AAAGGGCCTT GCTTGATGGC ACGAGTATCC ATGAGTGCGC GCTTGGCTCT 420

GATGGCAAGG TGATTGATTC TATAGCGTGC GGGAACGCTA GAGCCAATAA AATCCGCCGT 480

AATTACTTGA TGAATAACGC TTTTTTAGAA TACCGCTATA AGGATATATT TGCGGCTAAA 540

GGGGGGCGTT ATCAATCCAA TGCTCCTTAT ATGAGCTCTT ATACGCAAGG CTTTGAAATC 600

AGCGCTAAAA TCAAGGATAA AAATGAGGGG AGCCATAAAT TATGGTGGTT TAGCTCATGG 660

GGTAGGGCGT TCGCTTATGG GGAGTGGATT TATGATTTTT ACTCTCCAAG AACCGTGATT 720

AAAAACGGGC GCACTCTAAA TTATGGTATC CATTTAGTGG ATTACACTTA CGAAAGGAAA 780

GGGGTTAGCG TCAGCCCCTT TTTCCAGTTT TCGCCCGGGA CTTATTATAG CCCTGGGGTG 840

GCTGTAGGCT ATGATAGTAA CCCTAATTTT AATGGCGTGG GCTTTAGATC CGAAACGAAG 900

GCTTATATTT TGCTCCCTGT CCATGCCCCC CTTAAAAGGG ATACTTATCG TTACGCTGTG 960

AAAGCTGGCA CCGCTGGGCA AAGCCTGCTC ATTAGGCAAC GATTTGATTA CAATGAATTT 1020

AACTTTGGGG GAGCGTTTTA TAAAGTATGG AAAAACGCAA ACGCTTACAT AGGCACGACA 1080

GGAAACCCTC TAGGCATTGA TTTTTGGACC AATAGCGTTT ATGATATAGG GCAAGCCTTA 1140

AGCCATGTGG TAACCGCTGA TGCCGTCTCT GGTTGGGTTT TTGGTGGAGG CGTGCATAAA 1200

AAATGGCTGT GGGGGACTTT GTGGCGTTGG ACTAGCGGCG CTTTAGCCAA TGAAGCGAGC 1260

GCGGCTGTTA ATGTGGGCTA TAAGATCAGT AAGAGTTTGA CAGCGAGCGT GAAATTAGAA 1320

TATTTGGGCG TGATGACGCA TTCAGGCTTT ACGGTAGGGA GTTACAGACC CACGCCCGGC 1380

TCTAAAGCAC TTTATTCAGA CAGGAGCCAT CTAATGACAA CCCTTAGCGC CAAATTCTAA 1440

(2) INFORMATION FOR SEQ ID NO: 365:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1440 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1440

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 365:

ATGAAAAATA GCGCGCCTTT AAAGAATAAA GTTTTTTGTG GGTTATACGT TTTAAGTTTA 60 AGCGCTTCTG TGCAAGCGTT TGATTATAAA ATTGAAGTTT TGGCAGAGTC CTTTTCTAAA 120 GTTGGCTTTA ATAAAAAAAA GATTGACATA GCTAGGGGGA TTTATCCTAC AGAGACTTTT 180

GTAACCGCTG TGGGTCAGGG CAATATTTAT GCGGATTTTT TATCCAAAAG CCTTAAAGAT 240

CAAGGGCATG TTTTAGAGGG AAAAGTCGGC GGCACAATCG GTGGGATTGC TTATGACAGC 300

ACGAAATTCA ATCAAGGCGG ATCGGTTATT TATAATTATA TCGGTTATTG GGATGGCTAT 360

TTAGGGGGTA AAAGGGCCTT GCTTGATGGC ACGAGTATCC ATGAGTGCGC GCTTGGCTCT 420

GATGGCAAGG TGATTGATTC TATAGCGTGC GGGAACGCTA GAGCCAATAA AATCCGCCGT 480

AATTACTTGA TGAATAACGC TTTTTTAGAA TACCGCTATA AGGATATATT TGCGGCTAAA 540

GGGGGGCGTT ATCAATCCAA TGCTCCTTAT ATGAGCTCTT ATACGCAAGG CTTTGAAATC 600

AGCGCTAAAA TCAAGGATAA AAATGAGGGG AGCCATAAAT TATGGTGGTT TAGCTCATGG 660

GGTAGGGCGT TCGCTTATGG GGAGTGGATT TATGATTTTT ACTCTCCAAG AACCGTGATT 720

AAAAACGGGC GCACTCTAAA TTATGGTATC CATTTAGTGG ATTACACTTA CGAAAGGAAA 780

GGGGTTAGCG TCAGCCCCTT TTTCCAGTTT TCGCCCGGGA CTTATTATAG CCCTGGGGTG 840

GCTGTAGGCT ATGATAGTAA CCCTAATTTT AATGGCGTGG GCTTTAGATC CGAAACGAAG 900

GCTTATATTT TGCTCCCTGT CCATGCCCCC CTTAAAAGGG ATACTTATCG TTACGCTGTG 960

AAAGCTGGCA CCGCTGGGCA AAGCCTGCTC ATTAGGCAAC GATTTGATTA CAATGAATTT 1020

AACTTTGGGG GAGCGTTTTA TAAAGTATGG AAAAACGCAA ACGCTTACAT AGGCACGACA 1080

GGAAACCCTC TAGGCATTGA TTTTTGGACC AATAGCGTTT ATGATATAGG GCAAGCCTTA 1140

AGCCATGTGG TAACCGCTGA TGCCGTCTCT GGTTGGGTTT TTGGTGGAGG CGTGCATAAA 1200

AAATGGCTGT GGGGGACTTT GTGGCGTTGG ACTAGCGGCG CTTTAGCCAA TGAAGCGAGC 1260

GCGGCTGTTA ATGTGGGCTA TAAGATCAGT AAGAGTTTGA CAGCGAGCGT GAAATTAGAA 1320

TATTTGGGCG TGATGACGCA TTCAGGCTTT ACGGTAGGGA GTTACAGACC CACGCCCGGC 1380

TCTAAAGCAC TTTATTCAGA CAGGAGCCAT CTAATGACAA CCCTTAGCGC CAAATTCTAA 1440

(2) INFORMATION FOR SEQ ID NO: 366:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 516 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...516

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 366:

ATGGGCTTGA AAAATCTCTC AACACTTCTG GTGTTTTTAT TCTTTTGTTT GGGGTGTGTG 60

AGCAATTTTA ATGAAGACAC TTACACGCTA GACTTAGTTT TAGAAAAAAA GATCCAAGCC 120

AGTAGGAAAG GCGAAATCAC CCAAGATAAT GTGCCTATCA TCACGGCTAT CGCTACGCAT 180

TTAAACGATG TGGATAGCGG CACTTACTAC GATCATGAGT ATTTTTTAGT GGAGATTTTC 240

ACGCAAAATA ACGACTGGAT AGATGATGGC TATATTTCTT ATGAACTTTT TGGCACAAAA 300

CCTACAGGAT CAGAACCTTT ATGGGTGCGA GAGATTACAA GAGATGAATT TGATGGCATT 360

TTAGAAACCA CGAACCGGTG GAGCCGAGCC TTTTTGATCG CTTTTGACAA ATTGGATTAT 420

TTAGCGGTGC AAGAAGCCAA ACTAGAGCTT GATGCCTATA GTTTAGGCAA AATTGTTTTT 480

AATTTCGCTT ACCAAGTCCC CTTACCTCAA TTTTAA 516

(2) INFORMATION FOR SEQ ID NO: 367: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 255 base pairs

(B) TYPE- nucleic acid

(C) STRANDEDNESS. double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...255

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 367:

GTGAATAAAA AGCACCGCTT GGCTTTTTTA GGGCTAATTG TTGGGGTTCT ATTCTTCTTT 60

AGCGCGTGCC AACACCGCCT GCACATGGGG TATTATTCAG AAGTTACAGG GGATTATTTG 120

TTCAATTATA ATTCCACTAT CGTGGTGGCT TATGACAGAA GCGATGCGAT GACTTCTTAT 180

TATATCAATG TGATTGTTTA TGAATTGCAA AAATTAGGCT TTTATAATGT CTTCACGCAA 240

GCGAATTCCC GCTAG 255

(2) INFORMATION FOR SEQ ID NO: 368:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 756 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi ) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...756

(Xl) SEQUENCE DESCRIPTION: SEQ ID NO: 368:

ATGCAATATA AGAAAAATAA GAAAAGATAT TATCATTTAG CGTTAGGGAT CCTTTTTTGT 60

AATGGTCTGT CTTTGAAAGC TTTAGAAATT GCCGTCAAAC CCTTTGGCTA TCTGGGGCTA 120

TTGTATAATC AAGGGACGCA AAAAAACCCT CACAGCTATG TGGGGGCTTT AGCGCGTCTT 180

GGGGTGGATT TTTCTTATAG CAATGGGTGG TCGTTTGGTA TTGGGGCTAT TGGGGCTTGG 240

AATATTTATA ACAAACAGCG TTTGGCTAAC CTTTACATCA GTCTAGGGAA TTTTTTTGGT 300

AACCCTAACA ACGTTAAGCC TTATTTGAGC GCCGGCGATG TTTCTGATGC GTATCTTCAA 360 TACGCTAACC AGCGTTTTAA AATCGCTTTA GGGCGTTTTA ATACCGATTT TGTGGATTTT 420

GATTGGATAG GGGGCAATAT TCAAGGGGTC TCTGTGGCTT TCAAGCAAAA TTCCATGCGT 480

TATTTTGGGA TTTTTATGGA TAGCATGCTT TATAATGGGC ATCAAATCAA TAAAGAGCAA 540

GGGAATCGGA TCGCCACTTC CCTAAACGCT CTAGCGTCTT ATGATCCTGT GTCTAAACGC 600

TTGTATGTAG GGGGGGAAGT GTTTGTTTTG GGCGCAGAAT ACAAAAATAA AAATTTGATA 660

TTCGTTCCTT TTATTTTAAC GGACACCCGC TTGCCTTTGC CCACCCAAAA TGTTTTAGTG 720

CAAGTGGGGG GTAAGTTGGA GTATCGACGC TTCTTT 756

(2) INFORMATION FOR SEQ ID NO: 369:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 696 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...696

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 369:

ATGGTGCAAA AAATTGGCAT TTTAGGGGCG ATGAGAGAAG AAATAACCCC TATACTAGAA 60

TTGTTTGGCG TGGATTTTGA AGAGATCCCT TTAGGGGGGA ATGTTTTCCA TAAAGGCGTT 120

TATCATAATA AGGAAATCAT TGTCGCTTAT AGCAAGATTG GCAAGGTGCA TTCCACTTTA 180

ACCACAACAA GCATGATTTT AGCGTTTGGC GTTCAGAAGG TGCTTTTTAG CGGGGTGGCT 240

GGAAGCTTAG TTAAAGATTT AAAAATCAAT GATTTGTTAG TGGCTACTCA ATTAGTCCAG 300

CACGATGTGG ATTTGAGCGC GTTTGATCAC CCTTTAGGGT TTATCCCCGA AAGCGCGATT 360

TTTATTGAAA CGAGTGGAAG TTTAAACGCT TTAGCTAAAA AGATCGCTAA TGAGCAACAT 420

ATCGCGCTCA AAGAAGGCGT CATCGCATCA GGCGATCAGT TTGTGCATAG CAAAGAAAGG 480

AAAGAATTTT TAGTTAGCGA GTTTAAAGCG AGCGCGGTGG AAATGGAGGG GGCGAGCGTG 540

GCGTTTGTGT GCCAAAAATT TGGCGTGCCA TGCTGCGTGC TAAGGAGCAT TAGCGATAAC 600

GCCGATGAAA AAGCCGGTAT GAGTTTTGAT GAATTTTTAG AAAAAAGCGC TCACACTTCA 660

GCGAAATTCT TAAAAAGCAT GGTGGATGAG CTTTAG 696

(2) INFORMATION FOR SEQ ID NO: 370:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 678 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...678

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 370:

ATGAGAGCTA CGGCGATAAA AATCTTTTCA TTCTCATCAG CGCTCGCCCT ATTGCTTCAG 60

GGTTGCTTGA GCATTAATTT AAAACAAATG CTGCCAGAAA TCAGAACTTA TGATTTAAAT 120

GCGAGTTCTT TTGAAATGAC GCAATGCCCT AAACCTTTGA CTGAAGTGAG GCTCATTAGC 180

ATTTTGAGCG CGGATTTATT CAACACTAAA GAGATCGTGT TTAAAGCGCA AGACGGGCAG 240

ATCACGCATG GGAAGCACCA AAAATGGATA GACTTGCCTC GCAACATGTT AAAAACCATG 300

TTCATGCAAG AAGCGCAAAA AGCATGCTTA GGCGTGGCTT TGCCCCCTTA TGGCGCGGGC 360

GCGCCCACTT ATGCGGTTCG TTTTACGATT TTATCGTTTT CTCTTTTAGA AAAAGAAAAT 420

TCTACTTACA GGGCGGAATT CGCGCTAGGC TATGATATTA GCGTGAAAGG CGATTCGCAT 480

TCTGGAGTGA TCATTAAGCA TGAAAATATT TCTAGCTTGG AAAATAAAAC GACCAAAACG 540

AGTAAAAATG GCAGTCAAGA TTTCCAAGAA AGCGCGATAC AATCCCTCCA ACATGTCAGC 600

ACGCAAGCGA TGCAAGAAGC GATTTCTTTG ATTAAAAAAG CGGTTGAAGC GCAAAGCGTA 660

AGCCCGTTAA AAAAATAA 678

(2) INFORMATION FOR SEQ ID NO: 371:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 816 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...816

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 371:

TTGGAAAGGC ATGTGAATTA CACTTTAATC GGCGGGCTCT TCTTTTTATG CTTAGTGTGC 60

ATGGTAGGCT TTATTTTATG GCTAGGCCAT TTGGGATTAG ATGATGGGAA GTATTATGAA 120

TATGTGGTCT ATACGGACAA AGACTTGGGA GGCATTGCGA CCAACTCGCC CATTAATTAC 180

AAAGGGATTC AAGTGGGTAA TGTCATCAAA GTGGGTTTTG CAAAGGATAA AGTGGGGGTG 240

GTCCGTTTGG ATTTGATGAT CAAATCCAGC GTTAAGATCC GTAAAGATTC CAAAGTGGCG 300

GTTTCTTCTA GAGGGTTTAT GGGGTTAAAA TTTTTAGCCT TAGAGCAAAG CCACAATGAA 360

GAATTTTATG GTAGCGGCGA TAAAGGGGAG CGGATTTTAA TCTTTAAAGA AGGGCTTATG 420

GATCGCTTGA GCGGTGATGC TAATCAAGTG GTGCAAGAAG TGATGAAAGC GATCAGGAAT 480

GTGAATAGGA TTTTAGACGA TGAAAACGTG GAGAAATTCA AGCACATTCT CGCTTCAGTG 540

GATGATCTCA TCGCTAACTT GGATTCAAGA AAGACTCAAT TTGATTCCTT GATCAACAAC 600

GCTAACAACC TTGTTTCTAA TGTCAATAAT GTGGCTTTGG ATGTGGATAA ACGCGTCAAA 660 CAGGGGCAAT ACGACTTTAA GGCGATGTTC ACTCCTTTAA TCATGCAAGC GCAGTTGAGC 720 TTAAGAAACA TTGATAATTT TGTGGAAAAA GGCTCTGCTT TGATAGATAA ATTTGACGCT 780 AACCCCTATA AAACGATTTT TGGAGAAAGG AAATAA 816

(2) INFORMATION FOR SEQ ID NO: 372:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1053 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1053

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 372:

ATGAAAAAAA CTATTCTATT GAGCGCTCTT TTAGCTTTTT CTTGCGCTCA TGCTTTAAGC 60

GATATGGATT TGATTAAAAA AGCGAAGGAA AGCCAATTAG AACCCATGCC TATGGGCAAA 120

GCGCTCAAAG AATACCAGAT CAAAAAAACC AGAGATGTGG GCATTGGCGC TAAAAACAGC 180

GAAATCATGA CCTCCGCTCA AGTGGAATTA GGCAAAATGC TCTATTTTGA CCCTAGGATT 240

TCCACTTCCT ATCTTGTGTC TTGCAACACA TGCCATAATT TGGGCTTAGG CGGGGTGGAT 300

CTAATCCCAA GCGCTATAGG CTCTCAATGG AAGAAAAACC CCCACCTTTT AAGTTCCCCA 360

ACGGTGTATA ACTCTGTGTT TAACGATGTG CAGTTTTGGG ATGGTAGGGT TACGCATTTA 420

AACGAACAAG CGCAAGGGCC AATCCAATCT TCTTTTGAAA TGGGGGCTGA TCCTAAAGTC 480

GTGGTAGAAA AAATCAATTC CATACCAGGC TATGTCAAGC TCTTTAGAAA AGCTTATGGC 540

TCTAAAGTCA AAATTGATTT TAAATTGATC GCTGATAGTA TCGCTATGTT TGAAGCCACG 600

CTCATTACCC CAAGCCGTTA CGATGATTTT TTAAGGGGCA ATCCTAAAGC GCTCAGTAAA 660

GCCGAAAAAG AAGGGCTGGA TTTATTCATT TCTAAAGGCT GTGTGGCGTG TCATAATGGC 720

ATCAATCTTG GGGGGACGAT GCAGCCTTTT GGGGTGGTCA AACCTTATAA ATTCGCTAAT 780

GTGGGCGATT TCAAGGGCGA TAAAAACGGG CTTGTGAAAG TGCCTACTTT AAGGAATATC 840

ACCGAAACGA TGCCTTATTT CCATAACGGG CAATTCTGGG ATGTTAAGGA TGCGATTAAA 900

GAAATGGGCT CTATCCAGTT AGGCATTGAA ATCAGCGATG CAGAAGCGAA AAAGATTGAA 960

ACCTTCTTTG AAGCCTTAAA GGGTAAAAAA CCTAAAATAA TCTATCCAGA ACTCCCTGTG 1020

ATGACAGACA AAACCCCTAA ACCCTCTTTT TGA 1053

(2) INFORMATION FOR SEQ ID NO: 373:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 222 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...222

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 373:

ATGATGGATT TAGAAAGTTT GAGAGGTTTT GCGTATGCGT TTTTTACCAT TCTTTTTACG 60

CTCTTTTTGT ATGCTTATAT TTTTAGCATG TATAGAAAGC AAAAAAAGGG CATCGTGGAT 120

TATGAGCGAT ACGGGTATTT AGCGTTAAAT GATGCTTTAG AAGACGAGTT GATTGAACCA 180

CGCCATAAAG AAGTTCATGA TAAAGGCATA AAGGAAAGTT GA 222

(2) INFORMATION FOR SEQ ID NO: 374:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 828 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...828

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 374:

TTGCTAGATG TCAAAGCCAA TTCCCCCGCC TATCAAGCGG TGCTTTTAGC ATTGAACGCT 60

GCAGTGGGCT TGTGGCAAGT TACAAGCTAT GCCTTTACCG CTTGTGGTCC TGGTAGCAAT 120

GAGAACGCGA ATGGAGGTAT CCAAACCTTT AATAATGTGC CAGGACAAAA CACGACGACC 180

ATCACTTGTA ATTCGTATTA TGAGCCAGGA CATGGCGGGC CAATATCCAC TGAAAATTAT 240

GCGATCATCA ACAAGGCTTA TCAAATCATT CAAAAGGCTT TGACAGCCAA TGGAGAAGGG 300

ATCCCAGTTT TAAGCAACAC CACTACAAAA CTTGATTTCA CTATCAATGG AGACAAAAGA 360

ACGGGTGGCG AACCAAATAA AAAATTAGTA TACCCATGGA GTCATGGGAA ACCTATTTCA 420

ACCTCGTGGA ATGCAACCAT AACAGTACCA ACAACAGAAA ATATCAATAC AACCAATAGC 480

GCTCAAGAGC TTTTAAAACA AGCGAGCATC ATTATCACTA CCCTGAATAG TGCATGCCCA 540

AACTTCCAAA ATGGTGGTAG CGGTTATTGG GCAGGGATAA GTGGCAATGG GACAATGTGT 600

GGGATGTTTA AGAATGAAAT CAGCGCTATC CAAGGCATGA TCGCTAACGC GCAAGAAGCT 660

GTCGCGCAAG CCAAAATCGT TAGTGAAAAC ACGCAAAATC AAAACAGCCT AGACGCTGAA 720

AACCATTCAA CCCCTACACA GACGCTAGTT TTGCTGAAAG CATGCTCAAA AACGCGAAGC 780

CCAAGCGGAG ATTTTAAACC AAGCCGAACA AGTGGTGAAA AACTTTGA 828

(2) INFORMATION FOR SEQ ID NO: 375: (l) SEQUENCE CHARACTERISTICS

(A) LENGTH 273 base pairs

(B) TYPE nucleic acid

(C) STRANDEDNESS double

(D) TOPOLOGY circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL. NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...273

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 375:

ATGCTGACGA TTGAAACCAG TAAAAAATTT GATAAGGATC TTAAAATTCT TGTTAAAAAT 60

GGGTTTGATT TAAAGCTTTT GTATAAAGTG GTTGGAAATT TAGCCACAGA GCAACCCCTA 120

GAACCCAAAT ACAAAGACCA CCCACTCAAA GGCGCTTTAA AAGACTTTAG GGAATGCCAC 180

CTAAAACCGG ATTTATTGCT TGTCTATCAA ATTAAAAAAC AAGAAAACAC TCTTTTTTTA 240

GTAAGGCTAG GCAGTCATAG CGAGCTGTTT TGA 273

(2) INFORMATION FOR SEQ ID NO: 376:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 303 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM. Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY- mιsc_feature

(B) LOCATION 1...303

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 376:

ATGCTAGAAA TTGAATTAAA AAAGAAATTC ACTAAGGATT TAAAAAAGCA TATTTTAAAT 60

CAAAAAATTG AGTTAGAAGT TTTTGACTTA GTGGTTGAAA ATTTAAGAAA TCAAATTCCA 120

TTGGACAAAA GATTTAAAGA CCATGCTTTA AGTGGAACAT ACAAAGGCTG TAGAGAGCGC 180

CACATTAAGC CTGATGTTTT GCTTGTGTAT AGAGTGAAAG GCAATGTTTT AACTTTGGTT 240

AGGCTTGGCA GTCATAGCGA GCTGTTTTGT AAACCGCCCA CACCACTCAT AACGCTTAAA 300

TGA 303 (2) INFORMATION FOR SEQ ID NO: 377:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 270 base pairs (3) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...270

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 377:

TTGGTGGTTA GTGGCTCGTT GCAAAACATT GTTCGTTCTT TTTTGCGAAG GATCAGCGTT 60

TTCTTCATTA TTGATTTCAT CAATTTTATT TTCGTTATTG ATCAGATCAT TCACTTCTTT 120

GGTGACTTTT TCATCTTCTT CTTCATGCTC AATCTTTTTT ATATCCTTAT TAGGTTGATT 180

GATTTGATTG TTTTGAGTGG TTTTAGTGTT GTTTTGGTGC GATTGGGACG ATTTTTTAGG 240

CTCATCTTTG CAGGCGCTCA ACACGCTTAA 270

(2) INFORMATION FOR SEQ ID NO: 378:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1440 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1440

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 378:

ATGAAAAAAT CCCTTTGTTT GTCTTTCTTT CTGACCTTCT CTAACCCTCT TCAAGCCCTT 60

GTCATTGAGC TTTTAGAAGA GATTAAAACT TCGCCGCATA AAGGCACTTT TAAGGCTAAA 120

GTCCTTGATT CTAAAGAACC AAGACAAGTT TTAGGCGTTT ATAATATCTC CCCACACAAA 180

AAACTCACGC TCACTATCAC TCACATATCC ACGGCAATCG TCTATCAACC CCTTGATGAA 240

AAACTTTCTT TAGAAACGAC CTTAAGCCCT AACCGCCCTA CTATCCCTAG AAACACCCAA 300 ATCGTTTTTT CTTCAAAAGA ATTGAAAGAA CCGCACTCAA ACCCAATACC TTCTTTAAAC 360

GCGCCCATGC AAAAACCACA AAATAAACCC AGCTCATCGC AACAATCTCC TCAAAACTTT 420

TCTTACCCAG AGTCCAAACT AGGCTCTAAA AACTCTAAAA ACAGCCTTTT ACAGCCTTTA 480

GTAACTCCTA GCAAAGTAAG CCCCACTAAC GAAGTTAAAA CGCCAACAAA CGACGCTAAT 540

CCCCCTTTAA AGCATTCTTC ACAAGATCAA GAAAACAACC TCTTTGTAGC GCCACCCACT 600

GAAAAAACGC TCCCTAACAA CACCTCTAGT GCTGATGCGA GTGAAAACAA TGAAAGCAAC 660

GAAAATAGGG ATAATGTGGA AAAACAAGCG ATTAGAGATC CTAATATCAA AGAATTCGCA 720

TGCGGGAAGT GGGTTTATGA TGATGAAAAT TTACAAGCCT ATCGCCCAAG CATTTTAAAA 780

CGCGTTGATA AAGACAAAGA GATTACAACA GACATTACCC CTTGCGATTA CAGCACCGCT 840

GAAAATAAAA GCGGTAAAAT CATTACCCCC TATACTAAAA TCTCTGTTCA TAAAACAGAG 900

CCTTTAGAAG ACCCTCAAAC TTTTGAAGCT AAAAATAATT TCGCCATTCT CCAAGCCAGA 960

AGCTCTACAG AAAAGTGTAA AAGGGCTAGA GCGAGAAAAG ACGGCACGAC CAGGCAATGC 1020

TATCTGATAG AAGAGCCTTT AAAACAAGCG TGGGAGAGCG AGTATGAAAT CACCACGCAA 1080

TTAGTGAAAG CCATATATGA ACGCCCCAAA CAAGACGATC AAGTAGAGCC GACTTTTTAT 1140

GAAACCAGCG AATTGGCTTA TTCTTCCACA CGAAAAAGCG AAATAACGCG TAATGAATTG 1200

AATTTGAATG AAAAATTCAT GGAATTTGTG GAAGTGTATG AGGGGCATTA TTTAAACGAT 1260

ATAATCAAAG AGAGCAGCGA ATACAAAGAA TGGGTTAAAA ACCATGTGCG CTTTAAAGAA 1320

GGGGTGTGCA TGGCCTTAGA AATAGAAGAG CAACCACGAG CCAAAAGCAC GCCTTTGAGT 1380

ATTGAAAACT CTCGTGTTGT GTGTGTCAAA AAGGGGAATT ATTTATTCAA TGAAGTTTAA 1440

(2) INFORMATION FOR SEQ ID NO: 379:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1440 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1440

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 379:

ATGAAAAAAT CCCTTTGTTT GTCTTTCTTT CTGACCTTCT CTAACCCTCT TCAAGCCCTT 60

GTCATTGAGC TTTTAGAAGA GATTAAAACT TCGCCGCATA AAGGCACTTT TAAGGCTAAA 120

GTCCTTGATT CTAAAGAACC AAGACAAGTT TTAGGCGTTT ATAATATCTC CCCACACAAA 180

AAACTCACGC TCACTATCAC TCACATATCC ACGGCAATCG TCTATCAACC CCTTGATGAA 240

AAACTTTCTT TAGAAACGAC CTTAAGCCCT AACCGCCCTA CTATCCCTAG AAACACCCAA 300

ATCGTTTTTT CTTCAAAAGA ATTGAAAGAA CCGCACTCAA ACCCAATACC TTCTTTAAAC 360

GCGCCCATGC AAAAACCACA AAATAAACCC AGCTCATCGC AACAATCTCC TCAAAACTTT 420

TCTTACCCAG AGTCCAAACT AGGCTCTAAA AACTCTAAAA ACAGCCTTTT ACAGCCTTTA 480

GTAACTCCTA GCAAAGTAAG CCCCACTAAC GAAGTTAAAA CGCCAACAAA CGACGCTAAT 540

CCCCCTTTAA AGCATTCTTC ACAAGATCAA GAAAACAACC TCTTTGTAGC GCCACCCACT 600

GAAAAAACGC TCCCTAACAA CACCTCTAGT GCTGATGCGA GTGAAAACAA TGAAAGCAAC 660

GAAAATAGGG ATAATGTGGA AAAACAAGCG ATTAGAGATC CTAATATCAA AGAATTCGCA 720

TGCGGGAAGT GGGTTTATGA TGATGAAAAT TTACAAGCCT ATCGCCCAAG CATTTTAAAA 780

CGCGTTGATA AAGACAAAGA GATTACAACA GACATTACCC CTTGCGATTA CAGCACCGCT 840 GAAAATAAAA GCGGTAAAAT CATTACCCCC TATACTAAAA TCTCTGTTCA TAAAACAGAG 900

CCTTTAGAAG ACCCTCAAAC TTTTGAAGCT AAAAATAATT TCGCCATTCT CCAAGCCAGA 960

AGCTCTACAG AAAAGTGTAA AAGGGCTAGA GCGAGAAAAG ACGGCACGAC CAGGCAATGC 1020

TATCTGATAG AAGAGCCTTT AAAACAAGCG TGGGAGAGCG AGTATGAAAT CACCACGCAA 1080

TTAGTGAAAG CCATATATGA ACGCCCCAAA CAAGACGATC AAGTAGAGCC GACTTTTTAT 1140

GAAACCAGCG AATTGGCTTA TTCTTCCACA CGAAAAAGCG AAATAACGCG TAATGAATTG 1200

AATTTGAATG AAAAATTCAT GGAATTTGTG GAAGTGTATG AGGGGCATTA TTTAAACGAT 1260

ATAATCAAAG AGAGCAGCGA ATACAAAGAA TGGGTTAAAA ACCATGTGCG CTTTAAAGAA 1320

GGGGTGTGCA TGGCCTTAGA AATAGAAGAG CAACCACGAG CCAAAAGCAC GCCTTTGAGT 1380

ATTGAAAACT CTCGTGTTGT GTGTGTCAAA AAGGGGAATT ATTTATTCAA TGAAGTTTAA 1440

(2) INFORMATION FOR SEQ ID NO: 380:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 903 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_£eature

(B) LOCATION 1...903

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:380:

ATGAGAAAAA CGATTTCAGC GTTGTTTTTA TCAGCGTGTA TAGGGTTATC GTCTGTTCAT 60

GCGAGTAACG CTTTGATTTT ACAAACAGAT TTTAGCCTAA AAGATGGGGC CGTCTCGGCG 120

ATGAAAGGCG TCGCTTTCAG CGTTGATTCT AATCTTAAAA TCTTTGATTT AACGCACGAA 180

ATCCCCCCGT ATAACATTTG GGAAGGCGCT TACCGCTTGT ATCAGACCGC TAGTTATTGG 240

CCAAAAGGCT CGGTATTTGT GAGCGTAGTG GATCCGGGCG TAGGCACTAA TCGTAAATCG 300

GTGGTATTGA AAACTAAAAA CGGCCAGTAT TTCGTCTCTC CAGATAACGG CACGCTGACT 360

TTGGTAGCGC AAACTTTGGG GATTGATAGC GTGCGTGAAA TTGATGAAAA AGCCAACCGC 420

TTGAAAGGTT CTGAAAAATC CTATACTTTC CATGGCCGTG ATGTGTATGC TTACACTGGG 480

GCGCGCTTGG CTTCTGGGGC GATCACATTC GAGCAGGTCG GGCCAGAGCT TCCTATAAAA 540

GTTGTTGAAA TTCCTTACCA AAAAGCGAAA GCCACAAAAG GGGGAGTGAA AGGCAATATC 600

CCGATTTTGG ATATTCAATA TGGCAATGTT TGGAGCAATA TCAGCGATAA ACTGCTCAAT 660

CAAGCAGGGA TCAAACGAAA CGATACAGTG TGTGTAACTA TTTTTAAAAA TTCCAAGAAA 720

CAATACGAAG GGAAAATGCC GTATGTCGCG AGCTTTGGCG ATGTGCCAGA AGGCCAGCCG 780

TTGGTCTATT TAAACAGCTT GTTGAATGTT TCCGTGGCGT TGAATATGGA TAATTTCGCG 840

CAAAAACATC AAATTAAATC TGGTGCTGAC TGGAATATTG ATATAAAGAA GTGCGCTAAA 900

TAA 903

(2) INFORMATION FOR SEQ ID NO: 381:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 471 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double (D) TOPOLOGY: circular

(11) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE. NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...471

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 381:

TTGACTAAAA AATTCATGTC TTGGATGGTG GTTATCGGGG CTTTAATTTG CGTGCTTTTA 60

GGGGTGTTTA TCTTCTTCAC TAGCATGTCG GTTAAAAAAT CTTTAACCGC TTATCTTAAC 120

GCTTATTTAG AGCAACGCCC AAATATCGAG GGCATGGGGA TTATAGGAGT TCCTTTTAAA 180

TGCGAAAGGT TTTTTAAAAT CGCATGCGTT TCTAAAGAAC TTCGTTTTTT AGATCCTCAA 240

AACTCTCCTA TTATGGATTT TAAAAATTTA AAGATCAAGC TCCATTCTTT AGATAAAAGC 300

TCTCTTACCC TTTCTATCCA TTCTCAAATC CAATCCCCTA TTTTAGAACA ATCCATTCAG 360

CAAAAAATCA GCCAAATCCC CTTAAAAAAC TTGAATGCCT TATTGGAAAA ATTCAAACCC 420

ACGCGCTTGA ATTGCTCTTT AACATTCAAC GCTTTAGATG AAAAAACCTA A 471

(2) INFORMATION FOR SEQ ID NO: 382:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 858 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...858

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 382:

ATGCAAGATT TTATTAAGAT TTTTATTCAA GAGGTTGTCT CTACTTTAGA AGGGTTAGTG 60

GGTAAGGCTC CAAGCGTAGG ATTAGAAAAA GAAGTTTCTA ACAATGAAGA AGCGAGTTTA 120

ATCAGCACTC CTTATGCAAG GGTTAAGATT AGCGCGATTG AAAAAAATGA AAGTCCTATT 180

GAATTACTGG CTCCGGTAGA TTTAGTTACC GCTTTGAGCG ATTTGATGCT AGGAGGTGAG 240

GGGGCGAGCA AGGAAGAAAT GGATAATGAC GATTTAGACG CTTTTAAAGA AATGGCTTCT 300

AATATTTTTG GTGCGATCGC TACAAGCTTG AAGTCTCAAG AATTGCTCCC TAAACTCAAT 360

TTCACCACCA CGAACGCTGA AATCGCTAAA GAGCTTCCTA AAAAAGAAGA TTACGCTAAG 420

GCGATGGTGT TTTCTTTTAA AATGGAAGCC ATCAAAGAAA GCCAAATCGT TTTATTGATC 480 ACTTCAGCGT TTGAGGGCCA ATTTGAAAAA ACGCATAAAG AAGAAAAAGA AGAAACGACA 540

AAAAGCGCTA CTGAAGAGAC TAAAACCCAC GACGCGTCTT TAGAAAATAT AGAAATCCGC 600

AATATCAGCA TGCTTTTAGA CGTGAAATTG AACGTTAAGG TGCGTATCGG TCAAAAAAAG 660

ATGATTTTAA AAGATGTGGT CTCTATGGAT ATAGGGAGCG TGGTGGAGTT GGATCAATTG 720

GTGAATGACC CTTTAGAAAT CCTCGTAGAT GACAAGGTGA TCGCTAAGGG CGAAGTGGTG 780

ATCGTGGATG GGAATTTTGG CATTCAAATC ACGGATATTG GCACTAAAAA GGAACGATTA 840

GAGCAACTGA AAAATTAA 858

(2) INFORMATION FOR SEQ ID NO: 383:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 990 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...990

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 383:

ATGACGACTA AAAGAGTGAA TACTGCCACA AACAAGATAA TGACATTAAA CACTTTCTTG 60

GATACATGTT TTCTTTTCTT CATCAGTATT CTTTTTTACC TAAGTATACC AATTTATCCT 120

AACAAAGTGG TGGTTGTCCC GCAAGGTTCG CTCAAAAAAG TGTTTTTTTC TTTGAAAGAG 180

CAAGGCGTGG ATATTAACGC TTTAGATTTG CTTTTGTTGC GCCTAATGGG CATGCCTAAA 240

AAAGGCTATA TTGACATGGG CGATGGGGCT TTAAGGAAGG GGGATTTTTT AGTCCGTTTG 300

ATCAAAGCGA AAACGGCGCA AAAAAGCGTT ACTTTAATCC CTGGAGAAAC CCGCTATTTT 360

TTCACGCAAA TTTTGAGCGA GACTTACCAA CTAGAAACAA GCGATCTCAA TGAAGCTTAT 420

GAAAGCATCG CTCCACGATT AAACGGCGCT GTGATAGAAG ATGGGGTGAT ATGGCCAGAC 480

ACTTATCATT TACCTTTAGG GGAGGACGCT TTTAAAATCA TGCAAACTTT GATTGGTCAA 540

TCCATGAAAA AACACGAAGC CTTAAGCAAA CAATGGCTTG GATACTACCA TAAAGAAGAG 600

TGGTTTGAAA AAATCATTCT CGCTTCCATT GTGCAAAAAG AAGCCGCTAA TGTTGAAGAA 660

ATGCCCCTGA TTGCGAGCGT GATTTTTAAC CGCTTGAAAA AAGGCATGCC TTTACAAATG 720

GATGGGGCTT TGAATTATCA GGAATTTTCA CACGCTAAAG TAACCAAAGA GCGCATTAAA 780

ACCGATAACA CCCCCTACAA TACCTATAAA TTTAAGGGCT TGCCTAAAAA TCCTGTAGGG 840

AGCGTGAGCT TAGAAGCGGT TAGAGCCGTG GTTTTCCCTA AAAAAACGGA TTTCTTGTAT 900

TTTGTGAAAA TGCCGGATAA AAAACATGCT TTCAGCGCAA CTTATAAGGA GCATTTAAAA 960

AACATTAATA TTTCTAATAA TCATTTTTAA 990

(2) INFORMATION FOR SEQ ID NO: 384:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 441 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...441

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 384:

ATGAGATTGT TGTTCTTGTT ACTGAGCGCT ACTTTGATGT TACTGGCTGA AGAAAAAATA 60

CCTTTAAGCG ATGACGCCCC CATTAAATTG GTTCATTGGC AAAATGCGCT AAAAGAAGTC 120

CAACCCGATT CAAACGCTCC GGCAACGCCA CCTATAAAGG CCGTGCAAAC CACGCTCACT 180

TTTGAAACGC CTTTTAATAA AACGCCTAAA ATCATGGAGG TTGAAGGGCA AAAAGTCATC 240

GTGTTAAAAA ACGCTCAATT GGATTCTAAA AAAACGATGG ATTTTAAAGA AGCCTCTTTG 300

AATGCCTTAG AAATGTTTTC CTACCAAAAT GACATCTACC TCTTGTCTAA AAAAGCTAAA 360

GCGGGATTAG AAATCCAAGC TTCAAGCAGC AAGGATAAAA AGCAACTCGC TTTCTTTTTT 420

TACCCAAAGG TTTTCATTTA G 441

(2) INFORMATION FOR SEQ ID NO: 385:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1983 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1983

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 385:

ATGCTAAAAA AGATTTTTTA TGGTTTTATC GTTTTATTTT TGATTATCGT AGGGTTGTTG 60

GCCGTTCTTG TCGCTCAAGT TTGGGTAACT ACGGATAAGG ATATTGCTAA AATTAAAGAT 120

TATCGCCCCA GTGTCGCTTC ACAGATTTTA GACAGAAAAG GGCGTTTGAT CGCTAATATT 180

TATGATAAGG AATTTCGTTT TTATGCGCGT TTTGAAGAAA TCCCCCCACG ATTTGTTGAA 240

AGCCTTCTAG CGGTAGAAGA CACCCTCTTT TTTGAGCATG GGGGGATCAA TTTAGACGCT 300

GTCATGCGCG CTATGATTAA AAACGCTAAA AGTGGTCGTT ACACTGAAGG GGGTAGCACT 360

CTAACCCAAC AACTCGTTAA AAACATGGTG CTCACACGGG AAAAAACCCT AACCAGAAAA 420

CTCAAAGAAG CTATCATCTC CATACGCATT GAAAAAGTCT TAAGCAAAGA AGAAATTTTA 480

GAGCGTTATT TGAACCAAAC TTTTTTTGGG CATGGGTATT ATGGCGTGAA AACCGCAAGT 540

TTAGGGTATT TTAAAAAACC CCTTGACAAA CTCACGCTTA AAGAAATCAC CATGTTAGTC 600 GCCTTACCTA GGGCTCCAAG TTTTTATGAC CCTACCAAAA ATTTAGAATT TTCACTCTCT 660

AGGGCTAATG ATATTTTAAG GCGGTTGTAT TCTTTAGGCT GGATTTCTTC TAACGAGCTC 720

AAATCCGCTC TCAATGAAGT GCCAATCGTC TATAACCAAA CTTCCACGCA AAATATCGCT 780

CCCTATGTCG TGGATGAAGT GTTGAAGCAA TTGGATCAAT TAGACGGGTT AAAAACTCAA 840

GGCTATACCA TAAAACTCAC GATAGATTTG GATTACCAAC GCTTAGCGTT GGAGTCTTTG 900

CGTTTTGGGC ATCAAAAAAT CTTAGAAAAA ATCGCTAAAG AGAAGCCAAA AACTAACGCT 960

TCTAATGATA AAGATGAAGA CAACTTAAAC GCCAGCATGA TAGTTACAGA AACGAGCACC 1020

GGTAAGATTT TAGCCTTAGT GGGGGGGATT GATTATAAAA AAAGCGCTTT CAATCGCGCC 1080

ACGCAAGCCA AACGGCAGTT TGGGAGCGCG ATCAAGCCTT TTGTGTATCA AATCGCTTTT 1140

GATAATGGCT ATTCCACCAC TTCCAAAATC CCTGATACCG CGCGAAATTT TGAAAATGGC 1200

AATTATAGTA AAAACAGCGT GCAAAACCAC GCATGGCACC CTAGCAATTA TACTCGCAAA 1260

TTTTTAGGGC TTGTAACCTT GCAAGAAGCC TTGAGCCATT CGTTAAATCT GGCTACGATT 1320

AATTTAAGCG ATCAGCTTGG CTTTGAAAAA ATTTATCAAT CTTTAAGCGA CATGGGGTTT 1380

AAAAACCTCC CTAAAGATTT GTCTATTGTG TTAGGGAGCT TTGCTATCTC ACCGATTGAT 1440

GCGGCTGAAA AGTATTCTCT ATTTTCTAAT TACGGCACCA TGCTCAAACC CATGCTCATT 1500

GAAAGCATCA CCAACCAACA AAACGAAGTC AAAACTTTCA CGCCCATTGA AACCAAAAAG 1560

ATCACTTCCA AAGAACAAGC TTTTTTAACC CTTTCAGCGC TGATGGATGC GGTAGAAAAC 1620

GGCACAGGGA GTTTGGCTCG CATTAAAGGT TTAGAAATTG CCGGTAAAAC CGGGACTTCT 1680

AACAACAATA TTGACGCTTG GTTCATTGGC TTTACCCCCA CCTTACAAAG CGTGATCTGG 1740

TTTGGGAGAG ACGATAACAC GCCTATTGGC AAAGGAGCGA CAGGAGGCGT TGTGAGCGCG 1800

CCTGTGTATT CGTATTTCAT GCGCAATATC TTAGCGATTG AACCTTCTTT AAAAAGAAAG 1860

TTTGATGTCC CCAAAGGCTT GCGTAAAGAA ATCGTGGATA AAATCCCCTA CTACTCAAGC 1920

CCTAATTCCA TCACCCCCAC CCCCAAAAAA ACAGACGATA GCGAAGAACG CTTGTTGTTC 1980

TAA 1983

(2) INFORMATION FOR SEQ ID NO: 386:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 342 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...342

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:386:

ATGGCTAAAA TGAACGCTCC AGATGGGGTT GCCGTTTGGG TGAATGAAGA CAGGTGTAAG 60

GGTTGTGATA TTTGCGTGTC GGTATGCCCG GCTGGAGTTC TTGGCATGGG GATTGAAAAA 120

GAAAGGGTGC TTGGAAAAGT GGCCAAAGTA GCCTATCCAG AGAGCTGTAT TGGTTGCGTG 180

CAATGCGAGT TGCACTGCCC GGATTTTGCG ATTTACGTGG CTGACAGGAA GGATTTCAAA 240

TTCGCTAAAG TTTCTAAAGA AGCCCAAGAA AGAAGCGAAA AGGTTAAGGC CAATAAATAC 300

ATGCTCTTAG AAGAGACTAT TTTAGAAGGG AGAGGCAAAT AA 342

(2) INFORMATION FOR SEQ ID NO: 387: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1020 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1020

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 387:

ATGATTTTCA TTGACGCATG TTTTAGAAAG GAAACGCCTT ACACACCCAT TTGGATGATG 60

AGGCAAGCGG GGCGTTACCT TAGCGAATAC CAAGAGAGCC GTAAAAAAGC GGGGAGCTTC 120

TTGGAATTGT GTAAAAATAG CGATTTAGCC ACAGAAGTTA CCCTACAGCC GGTAGAGATT 180

TTAGGCGTGG ATGCGGCTAT TTTGTTTAGC GATATTTTAG TAGTGCCTTT GGAAATGGGC 240

TTGAATTTGG AGTTTATCCC CAAAAAGGGG CCGCATTTTT TAGAGACGAT TACGGATTTA 300

AAAAGCGTGG AAAGCCTAAA AGTAGGGGTT TATAAACAAC TAAACTATGT CTATGATACG 360

ATTTCTCAAA CGCGCCAAAA GCTTTCTAAA GAGAAAGCGC TAATCGGTTT TTGCGGATCG 420

CCTTGGACTT TAGCGACTTA CATGATAGAA GGCGAGGGGA GCAAATCGTA TGCCAAAAGC 480

AAGAAAATGC TTTATAGCGA GCCTGAAGTT TTAAAAGCGC TTTTAGAAAA GTTAAGCCTT 540

GAATTGATAG AGTATTTGAG CCTTCAAATC CAAGCAGGGG TCAATGCAGT GATGATCTTT 600

GACTCATGGG CTAGCGCTTT AGAAAAAGAA GCGTATTTGG AATTCAGTTG GGATTATTTG 660

AAAAAAATCT CTAAAGAGCT TAAAAAACGC TATGCGCACA TCCCAGTTAT CCTTTTCCCT 720

AAAGGGATTG GCGCTTATTT GGATAGCATA GATGGGGAAT TTGATGTGTT TGGCGTGGAT 780

TGGGGCACGC CTTTAACTGC GGCAAAAAAG ATTTTAGGCG GTAAGTATGT TTTGCAAGGG 840

AATTTAGAGC CCACCCGCCT TTATGATAAA AACGCTTTAG AAGAAGGGGT TGAAAAGATT 900

CTAAAAGTCA TGGGCAATCA AGGGCATATT TTTAATTTAG GGCATGGGAT GTTGCCGGAT 960

TTGCCCAGAG AAAACGCCAA GTATTTAGTG CAATTAGTGC ATGCTAAAAC CAGGCGATAG 1020

(2) INFORMATION FOR SEQ ID NO: 388:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 579 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE: (A) NAME/KEY: misc_feature

(B) LOCATION 1...579

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 388:

GTGTTAGAAA AATCTTTTTT AAAAAGCAAG CAATTGGTTT TATGCGGGTT GGGTGTTTTA 60

ATGTTGCAGG CTTGCACTTG CCCAAACACT TCACAAAGAA ATTCTTTTTT ACAAGATGTG 120

CCTTATTGGA TGTTGCAAAA TCGCAGCCAG TATCTCACGC AAGGGGTGGA TAGCTCGCAC 180

ATTGTAGATG GTAAGGCAAC TGAAGAGATA GAGAAAATCG CTACCAAAAG AGCGACAATA 240

AGAGTGGCGC AAAATATCGT GCATAAACTT AAAGAAGCTT ATCTTTCTAA ATCCAACCGC 300

ATCAAGCAAA AGATCACTAA TGAAATGTTT ATCCAAATGA CAAAGCCCAT TTTTGACAGC 360

TTGATGAATG TGGATCGTTT AGGGATTTAT ATCAATCCTA ACAATGAAGA AGTGTTTGCG 420

TTGGTGCGCG CGCGTTCCTT TGATAAGGAC GCTTTGAGCG AAGGGTTGCA TAAAATGTCT 480

TTAGACGATC AAGCGGTGAG TATCCTTGTT TCTAAAGTGG AAGAAATCTT TAAAGATTCT 540

ATCAATTACG GAGACGTTAA AGTCCCTATA GCCATGTAG 579

(2) INFORMATION FOR SEQ ID NO: 389:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 330 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...330

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 389:

ATGCTTAGAA ATCAATTTCG TATCGTGTTT GTCTCTTGTA TTGTCGCTAG CAGTTTGCAA 60

GCTCAAGAAA ATACCCACAC TTTGGGTAAG GTAACCACTA AGGGTGAAAG GACTTTTGAA 120

TACAACAATA AAATGTATAT TGACAGGAAA GAGCTCCAAC AACGCCAAAG CAACCAAATC 180

CGTGATATTT TTAGGACTAG GGCGGATGTG AATGTGGCCA GTGGGGGCTT AATGGCGCAA 240

AAAATCTATG TTAGGGGGAT TGAGAGCCGT CTCTTAAGGG TAACGATAGA TGGCGTCGCT 300

CAAAATGGTA ACATTTTCCA CCATGACGCT 330

(2) INFORMATION FOR SEQ ID NO: 390:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 270 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...270

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 390:

GTGATGAAAA AAATCGTTGT GAGTTTATGC GTGGCGTTAG GTTTTTTAAG CGCGGATCCA 60

GCGCAGGCCA ATAAAGCGAT CAGTGATGCG GATTTGATTG AAGAGATAAG GGACTTGAAA 120

AAAATCATCA GCGCACAAAA CACGGAGATT AACCAATTAA GAAAAGTGCA AGAAGTCTTA 180

TCTGGGCAAT TAGGGGACAT GCGTAAGGAT ATATTAAGCA CTAGAGATTA CTGTATCAGC 240

TTAAGGCCTT ATATTTATAA TTGGCGCTAG 270

(2) INFORMATION FOR SEQ ID NO: 391:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 477 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...477

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 391:

TTGAATAAAT TTGGTTGGCG TGCGTGTTTT CTAACCCTTT TTTTTAGCGG GTATTCTAAA 60

AAAGCTCCTG GAACGATAGG GAGTTTAGTG GCGTTGTTAC TGGGCTTACC TATTTTAATT 120

TTTTCGGCTA ACACTTTGTT TTTAGGGGCG ATTTTTGTTG GGCTTATCGC TATTACTCAA 180

ATAGATAAGG AAGAAGAAGA GACTAAGAGG CATGACAGCT CTTACATTGT GATAGACGAA 240

TTAGTGGGCA TGTGGCTTGC GATGGCGATT AGCGGATTAT CGTTAGTGGG TGTGATCTTG 300

AGTTTTATCT TTTTTAGGAT CTATGATATT ACTAAACCCT CACTCATTGG CAAAATAGAC 360

AAAGAAGTTA AAGGGGGCTT AGGGGTTGTG GCTGATGACG CTTTAGCCGG GGTTTTAGCC 420

GGATTGAGCA CGTTATTAGC CATCAATATT TTAGGATTTT TTAACATTAA GTTTTAG 477

(2) INFORMATION FOR SEQ ID NO: 392:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 402 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular (11) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...402

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 392:

ATGGAGTTAA TTAAGAAATT GGAAAAAGAA AGCGAAGTTT TAAAGAAAGA TTTACAACAA 60

CATTCAAACG AGCTTTTTAA AATGTTGATT ATTGATAATG AAGATTTGTT TAAAGAGCAA 120

TTTGAGATTA TGTTTAAAGC ATGGGTTGAA ATCGTAAAAA TGATGTTTGA ATTAACCAAA 180

AAAACCAAAT TTGATGGCGA AATGATTGGC TACACAGAAG AACTTTTAAC CTTTTTAGTT 240

AGAGATTTTT TTAATGGGAT TTTTAAATCC AAAGTAATAC CTAAAATGCC TATTTTTTGC 300

GGTGATGTTA AATGCGAAGA TTTTAATGCC CTAAGAAGTT TAGTTTATCT TTCTGTGCTT 360

GAGTTGGAAG AAACGATAAA TCCTAATAAA ATCCCATTTT AA 402

(2) INFORMATION FOR SEQ ID NO: 393:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 402 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...402

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 393:

ATGGAGTTAA TTAAGAAATT GGAAAAAGAA AGCGAAGTTT TAAAGAAAGA TTTACAACAA 60

CATTCAAACG AGCTTTTTAA AATGTTGATT ATTGATAATG AAGATTTGTT TAAAGAGCAA 120

TTTGAGATTA TGTTTAAAGC ATGGGTTGAA ATCGTAAAAA TGATGTTTGA ATTAACCAAA 180

AAAACCAAAT TTGATGGCGA AATGATTGGC TACACAGAAG AACTTTTAAC CTTTTTAGTT 240

AGAGATTTTT TTAATGGGAT TTTTAAATCC AAAGTAATAC CTAAAATGCC TATTTTTTGC 300

GGTGATGTTA AATGCGAAGA TTTTAATGCC CTAAGAAGTT TAGTTTATCT TTCTGTGCTT 360

GAGTTGGAAG AAACGATAAA TCCTAATAAA ATCCCATTTT AA 402

(2) INFORMATION FOR SEQ ID NO: 394: (l) SEQUENCE CHARACTERISTICS-

(A) LENGTH. 378 base pairs

(B) TYPE- nucleic acid

(C) STRANDEDNESS double

(D) TOPOLOGY: circular

(i ) MOLECULE TYPE. DNA (genomic)

(ill) HYPOTHETICAL. NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...378

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:394:

ATGAAAAAGT TAGCCGCTTT ATTTTTAGTA AGCGCGTTGG GGGTTATGAG TTTGAACGCA 60

TGGGAGCAAA CCCTAAAAGC TAATGATTTG GAAGTGAAAA TCAAATCCGT GGGCAACCCC 120

ATTAAAGGCG ATAACACTTT TGTGCTTAGC CCCACTTTAA AAGGTAAGGC TTTAGAAAAA 180

GCTATCGTTA GGGTGCAGTT TATGATGCCT GAAATGCCCG GCATGCCAGC GATGAAAGAA 240

ATGGCGCAAG TGAGTGAAAA AAACGGCCTT TATGAAGCTA AAACCAATCT TTCCATGAAC 300

GGGACATGGC AGGTTAGGGT GGATATTAAA TCCAAAGAAG GCCAAGTTTA TCGCACTAAA 360

ACAAGCCTGG ATTTATGA 378

(2) INFORMATION FOR SEQ ID NO: 395:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1026 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...1026

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 395:

ATGAAACGGC TTTTATTGTT AGCCTTGGCC CTCTTTTTTA GCCTCTCATG CACTAACGCT 60

CAAGAAATTA AAGAAACTCA AGAGACTAAA AAAACTAAAG AAACTAAAAG CCAAACCCGT 120

TTTAACATTT CCACCACTAA GGTCATAGAA AAAGAATTTT CTCAAAGCCG GCGCTATTAC 180

GCGCTTTTAG AGCCTAATGA AGCGCTGATT TTTTCTCAAA CCCTGCGTTT TGATGGCTAT 240

GTGGAAAAGC TTTATGCGAA TAAAACCTAT ACCCCCATTA AAAAGGGCGA TAGGCTATTG 300 AGCGTGTATT CCCCT&AATT AGCGGGCGTT CAAAGCGAGC TGTTATCGTC ATTGAAATTC 360

AACCAGCAAG TGGGAGCGAT TAAAGAAAAA TTAAAACTAC TAGGGCTAGA AAACTTTAGC 420

ATTGAAAAAA TCATCAGCAG CCATAAAGTC CAAAATGAAA TCACTATTTA CTCTCGTTTC 480

AACGGCGTTA TTTTTAAAAA AAGCCCGGAT CTCAATGAGG GGAGTTTCAT TAAAAAAGGG 540

CAAGAGCTTT TCAAAATCAT AGATTTAAGC CGATTGTGGG CGCTTGTTAA AGTCAATCAA 600

GAGGATTTAG AATTTTTAAA AAACACGCAT CAAGCGATTT TGTTCGTAGA GGGGGTTAAA 660

GGCAAGCAAG CAATCACGCT TGAAAACATC AACCCCATCA TAAATGCGCA AGATAAAATG 720

CTAGAAGCGC GCTTCAATGT GCCTAATCTT AAATTGCTTT ATTACCCTAA CATGTTCGCT 780

CAAGTAGAAA TCTTTCACAA ACCCCAAAAA ATGAAGATCT TGCCTAAAGA AGCGGTTTTG 840

ATTAAGGGGG GGAAAGCTAT CGTGTTTAAA AAAGATGATT TTGGCTTAAG CCCGTTAGAA 900

ATTAAAGCCG TCCGCTTGAG CGATGGGAGT TATGAAATTT TAGAGGGTTT AAAAGCGGGC 960

GAAGAAGTCG CTAATAACGC TTTATTCGTG CTAGACGCTG ACGCTCAAAA CAATGGGGAT 1020

TATTGA 1026

(2) INFORMATION FOR SEQ ID NO: 396:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 363 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...363

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 396:

ATGGGCGTAG CGGTTGTTTT ATTTTTAACG CTAATTTTAT TGTTTTTAGT TTTAAGGGAT 60

TTTGGTTTAG CTAGCCCCAA ACAAAAGATT TTAGCTTTTT TAATCGTAGG GATTATAGGA 120

GCGAGCATCA GCGTTTATAC TTATAAACAA AACCAACAAA ACCAACAAGA AATCGCTTTG 180

CAAAGAGCGT TTTTAAGGGG GGAAACCTTG TTGTGTAAAG GCATCAAAGT CAATAACCAA 240

ACCTTTAATT TAGTGAGCGG GACTTTGAGC TTTTTAGGCA AAAAACAAAC CCCTATGAAA 300

GATGTTCTTG TGGATTTGGA TTCTTGTCAG ACGCTTCAAA AAGATCCCTT AATCCAACCT 360

TAA 363

(2) INFORMATION FOR SEQ ID NO: 397:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 999 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE.

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE

(A) NAME/KEY. mιsc_feature

(B) LOCATION 1...999

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 397:

ATGCGTTTTT TTATTTTATT TTTTATGGGT ATGCTTGGCG TTGGTTTTTC TCAAACCGAG 60

TTGGATTTAA AGGATTTAGA AAAAAAGCCC GCCGGGATCG TTAGGGATTA TTATTTATGG 120

CGTTATATTA GCGATAAAAA AACGAGTTTA GAAAACGCTA AAAAAGCCTA TGAATTGACT 180

CAAAATAAAA ACAGCGCCCT ACAAAAAGCC ATGCAAGAAA AAGGCGTAGA AAATTCAGAT 240

AAAAGCCCTG ATGCCAAAAT GCCTGAAGAT ATTTATTGCA AGCAAATTAC CTTAGAAAGC 300

ATGTTAGAAA CAACAGACGC TTTCCAAGCG AGTTGTATCG CTATCGCTTT AAAATCAAAA 360

ATCAGAGATT TTGATAAAAT CCCCATTCAA ACCTTTAAAC CTTTACAAGA AAAAATCAAA 420

GAGGCTTACC CCATTCTTTA TGAAGAATTA GAAATCTTGC AAAGTAAGAA CGTGAGCGCT 480

TCTTTGTTTA AGGCTAACGC GCAAGTGTTT AGCGCGCTCT TTAATCATTT GAGTTATGAA 540

AAAAAGCTCC AAATTTTTGA AAAGCATATC CCGATTAAAG AGTTAAACCG CCTTTTAGAT 600

GAAGATTACC CGGCGTTTAA CCGCTTGATC TATCAAGTCA TCTTAGATCC TAAATTGGAT 660

CATTTTAAAG ACGCTCTCGC TAAAAGTAAC GCCACCCAAA GCAACGCGCA AACCTTTTTT 720

ATTCTAGGAA TCAATGAAAT CTTGCACAAA AAAACTTCTA AAGCGCTCAA GTATTTTGAA 780

CGCTCAGAAG CGGTTGTCAA GGACGATGAT TTTTCAAAAG ACAGAGCGAT TTTTTGGCAG 840

TATTTAGCCT CTAAAAAGAA AAAAACTTTG GAGCACCTTT CACAAAGCCC AGCCCTAAAC 900

CTCTATAGTC TTTATGCGAG CCGCAAACCT CAAAACCACG CCCAGTTATC GCATCATTTC 960

TCATATCCAA AATTTAAGCC AAGAGAACCC TCCTTTTAA 999

(2) INFORMATION FOR SEQ ID NO: 398:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 474 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...474

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 398:

GTGCATCTAG CCCACTACCT CAAAAGGAAT TTTTCTTTTT TCCCTAGCGT GGATATTGTG 60

GATGGGGGGA CTATGGCTCA GCAACTCATT CCTTTAATCA CTTCGTATGA AAAGGTTTTG 120

ATTTTAGATT GCGTGAGCGC TAAAGGCGTT GAAATTGGCT CAGTTTATGC CTTTGATTTT 180

AAGGACGCTC CTAAAGAAAT CACATGGGCT GGGAGTGCGC ATGAAGTGGA AATGCTGCAC 240

ACTTTAAGGC TCACGGAGTT TTTAGGGGAT TTGCCTAAAA CTTTTATCGT GGGGCTTGTG 300 CCTTTTGTGA TAGGGAGCGA GACCACTTTC AAGCTTTCAA GCGAAATGTT AAACGCTTTA 360 GAAACAGCCC TAAAAGCCAT AGAAACCCAA CTCAACGCAT GGGGAGTTAA AATGCAACGC 420 ACCGATCATA TTGCCCTAGA TTGTATCGCT GAACTCTCTT ATAAGGGTTT TTGA 474

(2) INFORMATION FOR SEQ ID NO- 399.

(l) SEQUENCE CHARACTERISTICS.

(A) LENGTH. 924 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL. NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE-

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...924

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 399:

ATGAAAAAAG TCCTCTTACT AACTCTCTCT CTCTCTCTCT CGTTTTGGCT CCACGCTGAA 60

AGGAACGGAT TTTATTTAGG TTTAAATTTT GCAGAAGGAA GCTATATTCA AGGACAAGGT 120

AGCATCGGCG AAAAAGCTTC AGCAGAAAAC GCCTTAAATC AAGCGATCAA TAACGCAAAA 180

AATTCATTAT TCCCTAACAC AAAAGCCATA AGAGATGTGC AAAACGCCTT AAATGCAGTG 240

AAAGATTCAA ACAAAATCGC TAACCGATTC GCAGGAAATG GTGGATCGGG CGGTATTTTC 300

AATGAACTCA GCTTGGGGTA TAAATATTTT TTGGGTAAAA AAAGGATTAT AGGGTTTAGG 360

CACTCTCTTT TTTTCGGTTA CCAACTTGGT GGCGTTGGTT CTGTTCCTGG CAGCGGTTTA 420

ATAGCTTTTT TACCCTATGG TTTCAATACG GATTTGCTCA TTAATTGGAC TAACGATAAG 480

CGAGCGTCTC AAGAATACGT TGAAAGAAGG GTAAAAGGGC TCTCTATATT TTACAAAGAT 540

ATGACCGGCA GAACGCTAGA CGCTGATACA TTAAAAAGAG CATCAAGGCA CATAATCAGA 600

AAATCTTCAG GGCTTGTGAT TGGCATGGAA CTAGGGGCTA GCACTTGGTT TGCAAGTAAC 660

AATCTCACCC CTTTTAATCA AGTCAAGAGT CGCACGATTT TTCAGTTACA AGGGAAATTT 720

GGCGTTCGTT TTAGTAGTGA TGAATACGAT ATTGATCGCT ATGGCGATGA AAACTATCTT 780

GGGGGTTCTA GTGTTGAATT AGGGGTTAAA GTGCCAGCGT TTAAAGTCAA TTATTATAGC 840

GATGATTACG GGGATAAATT GGATTATAAA AGAGTGGTGA GCGTTTATCT TAACTATACG 900

TATAACTTTA AAAACAAACA TTAA 924

(2) INFORMATION FOR SEQ ID NO: 400:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1737 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic) (ill) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1737

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 400:

ATGTCAAAAA AAATCGTAGT CGATCCTATC ACTAGGATTG AGGGGCATTT AAGGATTGAG 60

GTGATCGTAG ATGATGATAA TGTGATCACC GATGCGTTTT CTTCTTCTAC GCTTTTTAGG 120

GGGCTAGAAA CGATCATTAA GGGCAGAGAC CCACGAGATG CAGGCTTTAT CGCTCAAAGG 180

ATTTGTGGGG TATGCACTTA TTCGCATTAT AAAGCCGGTG TTACTGCGGT AGAAAACGCT 240

TTAGGAATCA CTCCCCCATT AAACGCGCAA TTGGTGCGAT CTTTGATGAA CATGGCGTTG 300

CTTTTTCACG ATCATGTGGT GCATTTCTAT ACTTTGCATG GGCTTGATTG GTGCGATATT 360

TTGAGCACTT TAAAAGCTGA TCCCATTCAA GCAGCAAAAC TTTCTTTCAA ATACAGCCCT 420

TATCCCATTA ATACCGGTGC GGGCGAATTA AAAGCGGTTC AAAAACGCTT GAATGATTTC 480

GCTAAAAGCG GATCTTTAGG GCCTTTTAGC AATGGCTATT ATGGGCATAA AACCTATCGT 540

TTAAACCCAG AACAAAATTT AATCGTCTTA AGCCACTACC TCAAGCTTTT AGAAATCCAA 600

AGGGAAGCGG CGAAAATGAC CGCTATTTTT GGGGCCAAAC AACCTCACCC ACAAAGCCTA 660

ACGGTGGGGG GTGTTACGAG TGTCATGGAT AT TTGGATC CAACAAGGTT GGCTGAATGG 720

AAGAGCAAGT TTGAAGTGGT GGCTAATTTT ATCAACCATG CTTACTACCC TGATTTGGTG 780

ATGGCAGGCG AAATGTTCGC TAACGAACCA TCTGTTATTA AAGGCTGTGG TTTAAGGAAT 840

TTTATCGCTT ATGAAGAAGT GTTGCTTGGG AAGGATAAAT ACCTTTTGAG TAGTGGGGTG 900

GTGCTTGATG GGGATATTTC TAAATTACAC CCCATTGATG AAAGTTTGAT TAAAGAAGAG 960

GTTACGCATT CTTGGTATCA ATATGAAGAC ACTAAAGAAG TGCAACTCCA CCCTTATGAC 1020

GGGCAAACTA ACCCGCATTA TACCGGTTTA AAAGACGGCG AGAGCGTGGG GATTGAAAAT 1080

AAAATAATCC CTGCTAAAGT GCTTGACACT AAGGATAAAT ATTCTTGGAT AAAATCGCCC 1140

AGATACGATA GTAAGCCCAT GGAAGTAGGG CCTTTAAGTT CCGTAGTGGT AGGTTTAGCG 1200

GCGAAAAACC CTTATGTTAC TGAAGTGGCT ACTAAATTTT TAAAAGACAC GAAACTGCCT 1260

TTAGAGGCGT TGTTTTCAAC GCTTGGGCGC ACAGCTGCAA GGTGTATTGA AGCTAAGACT 1320

ATCGCTGATA ATGGTCTTTT GGCGTTTGAC GCGTTAGTGG AAAATCTAAA GAGCGATCAA 1380

AGCACTTGTG CTCCTTATCA TATTGATAAA AATCAAGAAT ATAAAGGGCG CTACATTGGT 1440

CAAGTGCCAA GGGGCATGTT AAGCCATTGG GTGCGTATTA AAAACGGCGT GGTGGAAAAT 1500

TATCAAGCGG TAGTGCCTTC CACTTGGAAT GCAGGGCCTA GAGATTCTAA AAATCAAAGG 1560

GGGGCTTATG AAATGAGCTT GATTGGCACT AAAATCGCTG ATTTAACCCA GCCTTTAGAA 1620

ATCATTAGGA CTATCCATTC TTTTGATCCA TGCATCGCAT GCTCAGTGCA TGTGATGGAT 1680

TTTAAAGGGC AGTCTTTGAA CGAGTTCAAA GTAGAGCCTA ATTTCGCTAA ATTCTAA 1737

(2) INFORMATION FOR SEQ ID NO: 401:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 207 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori ( ix ) FEATURE -

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...207

(xi) SEQUENCE DESCRIPTION: SEQ ID NO -401:

ATGAATAGTT CTAACCTCAA AAATTGGCTA TTCCCCACTA TTTGCTTTTT TTTATTTTGT 60

TATATTTTAA TTTTTTTGAT ATTTTTTATG TTTAAAAACT TGCAATCGCA ATCTTTTGGC 120

TCTGTGGCAG AAACCGGAAA AAAACCCATC ACCACCACCA AGAAATTTGG TAAGGAATTG 180

CAAAAACAGA TTTCAAAAAT CCATTAA 207

(2) INFORMATION FOR SEQ ID NO: 402:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 162 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...162

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:402:

GTGGTCTTGC CTAAAGAAAC CTTATCTTCT ATCGCTAAAC GCTATCAAGT CAGCATTTCC 60 AGTATCCAAT TAGCCAATAA CCTCAAAGAT TCTAATATCT TTATCCACCA GCGCTTAATC 120 ATCCCCACTA ACAAAAAATT ACTCGCTACA AGGGAATTTT AA 162

(2) INFORMATION FOR SEQ ID NO: 403:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1059 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(lli) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi ) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature (B) LOCATION 1...1059

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 403:

TTGTATTTCC TTAATGGTGG TTATAATCGG CTTCATAAAT CATACGAAAG GATTGTCATG 60

CTAATCGCTC GCTTTAAAAA AGCTTTAATT TCCTATTCTT TAGGGGTTCT TCTTGTTTCA 120

TCGTTATTAG GCGTGGCTAA CGCTTCTAAT CAAGAGATCC AAGTCAAGGA TTATTTTGGG 180

GAGCAAACCA TAAAGCTTCC TGTTTCTAAA ATAATCTACT TGGGCAGCTT TGCAGAAGTG 240

CCTGCCATGT TCAATACTTG GGATAGGGTC GTGGGCATTT CGGATTACGC TTTTAAATCT 300

GATATTGTTA AAGCCACTCT CAAAGATCCT GAACGCATTA AACCCATGAG CAGTGATCAT 360

GTGGCGGCGT TGAATGTGGA ATTATTAAAA AAGCTTAGCC CTGATCTTGT GGTAACCTTT 420

GTGGGTAACC CTAAAGCGGT AGAGCATGCG AAAAAATTTG GGATTTCATT CCTTTCTTTC 480

CAAGAAAAAA CCATTGTAGA GGTCATGGAA GATATTGACG CTCAAGCTAA GGCCTTAGAA 540

GTTGACGCTT CTAAAAAATT GGCTAAAATG CAAGAAACTT TGGATTTTAT CAAAGAGCGT 600

TTGAAAAATG TCAAAAAGAA AAAGGGGGTG GAGCTTTTCC ATAAAGCCAA TAAAATCAGC 660

GGCCATCAAG CCCTTGATTC AGATATTTTA GAAAAAGGGG GCATAGACAA TTTTGGCTTG 720

AAATACGTCA AGTTTGGGCG CGCTGACATT AGTGTGGAAA AAATCGTTAA AGAAAACCCT 780

GAGATTATTT TTATTTGGTG GATAAGCCCG CTTAGCCCTG AAGACGTGTT GAACAACCCT 840

AAATTTTCCA CTATCAAAGC CATTAAAAAC AAGCAAGTCT ATAAGCTCCC CACAATGGAT 900

ATTGGCGGAC CTAGAGCCCC ACTCATTAGT CTTTTTATCG CTTTAAAAGC CCACCCTGAA 960

GCGTTTAAGG GCGTGGATAT TAATGCGATA ATCAAAGATT ACTATAAAGT GGTCTTTGAT 1020

TTGAATGACG CGGAAGTTGA ACCCTTTTTG TGGCACTGA 1059

(2) INFORMATION FOR SEQ ID NO: 404:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 594 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...594

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 404:

ATGAAGTGCT CAAGCTTTAC CTCTAATAGC GTCTTAAACT TTTTTGTAGT TTTGTCTTTC 60

ATCACGATAG GGCTAGTGTT TTTCTTTTTG CGTTCCCAAC CAACTAGCGT AGTTTCTAAA 120

GAAAATATCC CTAAAATTGA ATTAGAAAAT TTTAAAGCGT TTCAAATCAA CGATAAAATC 180

CTTGATCTGT CCATAGAGGG CAAAAAAGCC CTACAATACG ATGATCATGA AATCTTTTTT 240

GATTCTAAAA TCAAGCGCTA TGATGAAGAC ACCATTGAAA GCGTTGAGTC CCCTGAAGCC 300

AAACGGCAGC AGGATTTGTA TTTCTTCCCT AACGGGGTAA CTTATAAAAG AAGCGATGAT 360

TCCAGTTTTT GGAGTGAAAC AGGGATTTAT AACCATAAGG AGCAAAATTT TAAAGGCAAG 420

GGCCGTTTCA TTCTCACTTC AAAGGACAGC AAGGTTGAAG GGCTTGACAT TTCTTATTCG 480

CATGCATTAG CTATTATTGA AGCTCAAAGC ATTCAAGCCA ATTTGTTTTT AGATGAAATC 540

AAACAAAGCC AGAAAGAAAA GAAAAAATTC CCCACTTTCA AAGGAGGGTT TTAA 594 (2) INFORMATION FOR SEQ ID NO -405

(l) SEQUENCE CHARACTERISTICS.

(A) LENGTH 558 base pairs

(B) TYPE nucleic acid

(C) STRANDEDNESS. double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...558

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 405:

ATGCGTTGGT GGTGTTTTTT GGTGTGTTGT TTGAGCGTTT TAAGCGTGAT GGACGCTAAA 60

AAATTAGAGA ATAAAGGCTT GAAAAAAGAA AGAGAGCTTT TAGAAATTAC CGGCAACCAA 120

TTTGTAGCGA ACGACAAAAC CAAAACCGCC GTTATTCAAG GCAATGTGCA GATCAAAAAA 180

GGTAAAGACC GGTTGTTTGC GGATAAAGTG AGCGTGTTTT TAAACGATAA ACGAAAGCCA 240

GAACGCTATG AAGCCACAGG GAACACGCAT TTTAACATCT TTACAGAAGA TAATCGTGAA 300

ATCAGCGGGA GCACTGACAA GCTCATTTAT AACGCGCTGA ATGGGGAATA CAAATTATTG 360

CAAAATGCGG TGGTTAGAGA AGTGGGAAAA TCTAATGTCA TCACCGGCGA TGAAATCATT 420

TTAAACAAAA CCAAGGGTTA TGCTGATGTG TTGGGGAGCG CGAAGCGGCC CGCTAAATTT 480

GTGTTTGATA TGGAAGACAT TAATGAAGAA AATCGTAAGG CTAAATTGAA GAAAAAAGGC 540

GCTAAGGAAA AACCATGA 558

(2) INFORMATION FOR SEQ ID NO: 406:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 636 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...636

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 406: TTGATCCAAC AAAATTTTAA AACACTTAAG GAGTTGTATA TGTTAGTTAC AAAACTTGCC 60

CCCGATTTTA AAGCGCCTGC CGTTTTAGGA AACAATGAGG TTGATGAACA CTTTGAGCTT 120

TCTAAAAATT TAGGCAAAAA TGGTGTGATC CTTTTCTTTT GGCCAAAAGA TTTTACTTTT 180

GTATGCCCTA CAGAAATCAT TGCGTTTGAC AAAAGAGTGA AAGACTTCCA CGAAAAAGGC 240

TTTAATGTGA TTGGCGTGTC TATTGACAGC GAACAAGTGC ATTTCGCATG GAAAAACACC 300

CCTGTGGAAA AAGGCGGTAT CGGTCAAGTG TCTTTCCCTA TGGTGGCTGA TATCACTAAG 360

AGCATTTCTA GAGACTATGA TGTGCTGTTT GAAGAAGCGA TCGCTTTGAG AGGTGCTTTT 420

TTGATTGATA AAAACATGAA AGTAAGACAC GCAGTGATCA ATGACTTGCC ATTAGGTAGG 480

AATGCAGATG AAATGCTTCG CATGGTAGAC GCTCTCTTAC ACTTTGAAGA ACATGGTGAA 540

GTATGCCCAG CAGGTTGGAG AAAAGGCGAT AAAGGCATGA AAGCAACTCA CCAAGGCGTT 600

GCAGAGTATC TTAAAGAAAA TTCCATTAAG CTTTAA 636

(2) INFORMATION FOR SEQ ID NO: 407:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 591 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...591

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 407:

GTGCCGTTGT GGATTATGGT AGTAGGGGCA GCTGGGATCG CTTTAGGCTT GAGCTTGTAT 60

GGGCCAAAGC TCATTAAAAC GGTGGGGTCT GAAATCACAG AATTAGACAA AATGCAAGCT 120

TTTTGCATCG CGCTTTCAGC GGTCATCACC GTGCTTTTAG CCTCTCAATT AGGCTTACCG 180

GTAAGCTCTA CGCATATTGT GGTGGGCGCG GTGTTTGGGG TGGGCTTTTT AAGGGAGCGT 240

TTGAGGGAGC AATCCAGAAG GCGTTTTGCT AGAATCAGAG ACAACATTGT AGCGGCGCAC 300

TTTGGGGAAG ATTTAGAAGA AATTGAAGGC TTTTTAGAGC GCTTTGATAA AGCCAATTTG 360

AAAGAAAAAT CGCTCATGCT AGAGAGCTTG AAAAAAAGCA AGAACACCGC TATCGCTTTG 420

GAATTGAAAA AGAAAGAAAA AAAGTCGCTT AAAAAAGTGT ATAAAGAAGA AGTGATCAAA 480

CGCTCCATTT TGAAAAAGAT TGTTACCGCT TGGTTGGTAA CCGTGCCGGT TTCTGCGCTT 540

TTAGGGGCGC TTCTTTTTGT AGCTCTTGGT TTTATAGAAA AGTATTTCTA G 591

(2) INFORMATION FOR SEQ ID NO: 408:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 525 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE

(A) ORGANISM Helicobacter pylori

(ix) FEATURE.

(A) NAME/KEY. mιsc_feature

(B) LOCATION 1.. 525

(xi) SEQUENCE DESCRIPTION. SEQ ID NO: 408:

ATGTCAAATA GCATGTTGGA TAAAAATAAA GCGATTCTTA CAGGGGGTGG GGCTTTATTG 60

TTAGGGCTAA TCGTGCTTTT TTATTTGGCT TATCGCCCTA AGGCTGAAGT GTTGCAAGGG 120

TTTTTAGAGG CTAGGGAATA CAGCGTGAGC TCTAAAGTCC CTGGCCGCAT TGAAAAGGTG 180

TTTGTTAAAA AAGGCGATCG CATTAAAAAG GGCGATTTAG TTTTTAGCAT TTCTAGCCCT 240

GAATTAGAAG CCAAGCTCGC TCAAGCTGAA GCCGGGCATA AAGCCGCTAA AGCCGTTAGC 300

GATGAAGTGA AAAGAGGCTC AAGAGATGAA ACGATCAATT CTGCGAGGGA CGTTTGGCAA 360

GCGGCAAAAT CCCAAGCGAA TTTGGCTAAA GAGACTTATA AGCGCGTTCA AGATTTGTAT 420

GACAATGGCG TGGCGAGTTT GCAAAAGCGC GATGAAGCCT ATGCGGCTAT GAAAGCACCA 480

AATACAACGA GAGCGCGGCT TACCAAAAGT ATAAAATGGC TTTAG 525

(2) INFORMATION FOR SEQ ID NO: 409:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 447 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...447

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 409:

ATGGAATTTT TGAGCGGGTA TTTTTTATGG GTTAAAGCTT TCCATGTGAT AGCGGTCATT 60

TCGTGGATGG CAGCGTTATT TTATTTGCCA CGCCTTTTTG TCTATCATGC AGAGAACGCG 120

CATAAAAAAG AGTTTGTAGG CGTGGTTCAA ATCCAAGAGA AAAAGCTCTA TTCCTTTATC 180

GCTTCGCCGG CGATGGGTTT CACGCTTATT ACAGGGATTT TGATGTTGTT GATCGCCCCT 240

GAAATGTTTA AAAGCGGGGG TTGGTTGCAT GCTAAATTGG CTTTAGTGGT ATTGCTTTTA 300

ATCTATCATT TTTATTGCAA AAAATGCATG CGCGAGCTGG AAAAAGACCC TACAGGGAAA 360

AACGCAAGGT TTTATCGTGT GTTTAATGAA ATACCCACGA TTTTAATGAT CCTTATTGTG 420

ATCTTAGTGG TTGTCAAGCC TTTTTAA 447

(2) INFORMATION FOR SEQ ID NO: 410:

(l) SEQUENCE CHARACTERISTICS: (A) LENGTH: 438 base pairs

(B) TYPE- nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(11) MOLECULE TYPE. DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...438

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 410:

ATGAAACCAA TTTTTTTGTT AATCTTTTTG TTGTTAGCGA GCCTTATTGC TAGAGAAAAG 60

GACGCTTCTT CAAACCTTTT TGATTTGATC GATAAGGGGA TTAACAGAGA ACAAGAATTG 120

AAAGAGCAGG AGCAAAAAAC GCGCTTGAAA CTGGCTCAAA GCCCTTTAGT GGCGTTAGAA 180

ATTGTCCCCC AAGAAACGCC CTATTTAGAA TGGCAAGGGG CTAGGGAGTC GTATTATTTG 240

AAAGTGAGCG CTGTAGTGGA GAGCGTGGTT ATTTTAAAGA TTGACATCAA TCAGGGGCGT 300

TCTTGCTCGC TCTACCCCAC GCCTAAAAGC GTTTCTTTAG TGAGGAATCA AAGCGTAGCC 360

TATGAAATTT TATGCGAAAA CCAGCCGCTA TGGATAGAAG TTAGCACCAA TTTAGGCAAA 420

CGCACCTTTC AGTTTTAA 438

(2) INFORMATION FOR SEQ ID NO: 411:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 774 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...774

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 411:

ATGGCTAAGA AAAACAAACC CACCGAATGC CCCGCCGGCG AAAAATGGGC GGTTCCTTAT 60

GCGGACTTTT TGTCGTTGTT GCTCGCGCTT TTTATCGCTC TTTATGCCAT TTCAGCGGTC 120

AATAAATCCA AAGTGGAAGC CTTAAAAACC GAATTTATTA AGATTTTTAA TTACGCCCCA 180

AAGCCAGAGG CGATGCAGCC GGTTGTAGTG ATCCCCCCTG ATTCAGGGAA AGAAGAAGAG 240

CAAATGGCGA GCGAAAGCTC CAAGCCGGCT TCGCAAAATA CCGAAACAAA AGCCACTATC 300 GCTCGCAAGG GCGAAGGCAG TGTTTTAGAG CAAATTGATC AAGGCTCTGT TTTAAAGCTC 360

CCCTCTAGTT TGCTGTTTGA AAACGCCACT TCAGACGCTA TCAATCAAGA CATGATGCTT 420

TATATTGAAC GGATCGCTAA AATCATTCAA AAACTCCCTA AAAGGGTGCA TATTAATGTG 480

AGAGGTTTTA CGGATAACAC GCCTTTAAAT AAAACCCGTT TTAAAAGCCA CTATGAATTA 540

GCCGCCAATC GCGCTTATAG GGTGATGAAA GTCCTTATAC AATACGGCGT GGATCCTAAC 600

CAATTGTCTT TTTCTTCTTA CGGCTCTACC AACCCTATTG CGCCCAATGA TTCCCTAGAA 660

AACAGAATGA AAAACAATCG TGTGGAAATC TTTTTTTCAA CCGATGCGAA CGATTTGAGC 720

AAGATCCATT CTATTTTAGA TGAAGAATTC AATCCCCATA AACAGCAAGA ATGA 774

(2) INFORMATION FOR SEQ ID NO: 412:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2397 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL : NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...2397

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 412:

ATGAGAAAGG TTATCATAAT GAATGGTTAT TTGAGGGTAA AAACCCCGTA TTTTTTAGCG 60

TCGGTCGTTT TGACTTTTTG GACTTTTAAT TCTTTTATGA GCGCGAAAGA TAAGCACCAT 120

TTTTTAAAAA AAGTTACAAC CACCGAGCAA AAATTCAGTT CTAGTGCCCC AATTTCATGG 180

CAAAGCGAAG AGGTGCGTAA TTCCACAAGC TCTCGCACGG TGATTTCCAA CAAAGAACTC 240

AAAAAAACGG GGAATTTGAA TATTGAAAAC GCCTTGCAAA ATGTGCCAGG GATTCAAATC 300

AGAGACGCTA CAGGCACGGG CGTGCTGCCT AAAATTTCGG TGCGCGGTTT TGGTGGGGGC 360

GGTAACGGGC ATAGCAACAC CAACATGATT TTAGTCAATG GTATCCCCAT TTATGGCGCG 420

CCGTATTCCA ATATTGAACT GGCGATTTTC CCTGTAACTT TCCAGTCAGT GGATAGGATT 480

GATGTGATTA AGGGGGGAAC GAGCGTCCAA TACGGCCCTA ACACTTTTGG AGGCGTGGTG 540

AATGTCATCA CTAAAGAAAT CCCCAAAGAG TGGGAAAATC AAGCGGCTGA AAGGATCACT 600

TTTTGGGGGC GCTCCTCTAA TGGGAATTTT GTCGATCCCA AAGAAAAAGG CAAGCCCTTA 660

GCCCAAACTT TAGGAAACCA AATGCTGTTT AACACTTATG GGCGAACGGC TGGGATGTTG 720

GGTAAATATA TAGGCATTAG CGCTCAAGGC AATTGGATTA ATGGGCAAGG TTTCAGGCAA 780

AATAGCCCTA CAAAGGTGCA AAACTACTTG TTGGATGCGA TTTATAAGAT CAATGCGACC 840

AATACTTTTA AAGCTTATTA CCAGTATTAT CAATACAACT CTTACCATCC AGGCACTTTG 900

AGCGCGCAAG ATTACGCCTA TAACCGCTTC ATCAATGAGC GCCCTGACAA TCAAGATGGA 960

GGGCGAGCCA AGCGCTTTGG GATCGTGTAT CAAAACTACT TTGGCGATCC GGATAGGAAA 1020

GTGGGGGGCG ATTTTAAATT CACTTATTTC ACGCATGACA TGAGTAGGGA TTTTGGGTTT 1080

TCCAACCAAT ACCAAAGCGT GTATATGAGC GGTCAAAATA AGATTTTACC CTTTAAAGGC 1140

AAGGGAGAAA TCAGCGCAAA AAACCCTAAT TGCGGTCTGT ATTCTTATAG CGACACGAAT 1200

AGCCCTTGCT GGCAATTTTT TGACAATATC CGCCGATCCG TGGTGAATGC CTTTGAGCCA 1260

AAACTCAATC TTATCGTCAA TACTGGTAAA GTCAAACAAA CTTTTAACAT GGGAATGCGC 1320

TTTTTAACTG AAGATTTATA CCGCCGATCC ACCACCAGGA AAAACCCTAG CATGCCTAAT 1380

AATGGGAGTG GGTTTGATGC AGGAACTTCA CTCAATAATT TCAACAATTA TACCGCTGTG 1440

TATGCCAGCG ATGAAATCAA TTTCAATAAC GGCATGCTAA CGATCACGCC GGGCTTGAGA 1500 TACACTTTTT TAAATTACGA AAAAAAAGAC GCTCCTCCCT TTAAGGTGGG TCAAACCCCA 1560

AAAACCACGA AAGAGCGTTA TAACCAATGG AATCCGGCAG TCAATGTCGG CTATAAACCC 1620

ATTAAAGAAT TATTGTTTTA TTTCAATTAC CAAAGAAGCT ACATTCCGCC CCAATTCAGC 1680

AATATCGGTA ATTTTGTAGG CACAAGCACG GATTATTTTC AAATCTTTAA TGTCATGGAA 1740

GGCGGCTCAA GATATTATTT TAACCATCAA GTGAGTTTTA ACGCGAACTA TTTTGTGATT 1800

TTTGCGAATC ATTATTTTAC CGGGCGCTAT GGGGACAACA GAGAGCCGGT CAATGCGAGA 1860

TCGCAAGGCG TGGAGCTGGA ACTCTACTAC ACGCCTATTA GGGGGCTTAA TTTCCATGCG 1920

GCTTACACTT TTATAGACGC TAATATCACA AGCCACACGA TGGTTACTAA CCCTGCTAAT 1980

CCTAAAGGGC CTAAAAAAGA TATTTTTGGC AAAAAGCTCC CTTTTGTCAG CCCGCACCAA 2040

TTCATTTTAG ACGCGAGTTA CACTTACGCT AAAACCACGA TTGGGTTAAG CTCTTTCTTT 2100

TATAGCCGCG CTTATAGCGA TGTGTTAAAC ACCGTGCCTT TTACAGAATA CGCGCCCACG 2160

ATTAAAAATG GGGCTATCGT TACCAAAACA GCGGGCATGA CGCCGTACTA TTGGGTGTGG 2220

AATTTGCAAA TTTCTACCAC TTTGTGGGAA CGCAAAAATC AAAGCGTGAA TGCGAGCTTG 2280

CAAATCAATA ACATTTTTAA CATGAAATAT TGGTTTAGCG GGATAGGCAC TAGCCCTAAC 2340

GGGAAAGAAG CTGCGCCTCC CAGGAGCATC ACAGCGTATG TGAGTTATAA TTTTTAA 2397

(2) INFORMATION FOR SEQ ID NO: 413:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2397 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...2397

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 413:

ATGAGAAAGG TTATCATAAT GAATGGTTAT TTGAGGGTAA AAACCCCGTA TTTTTTAGCG 60

TCGGTCGTTT TGACTTTTTG GACTTTTAAT TCTTTTATGA GCGCGAAAGA TAAGCACCAT 120

TTTTTAAAAA AAGTTACAAC CACCGAGCAA AAATTCAGTT CTAGTGCCCC AATTTCATGG 180

CAAAGCGAAG AGGTGCGTAA TTCCACAAGC TCTCGCACGG TGATTTCCAA CAAAGAACTC 240

AAAAAAACGG GGAATTTGAA TATTGAAAAC GCCTTGCAAA ATGTGCCAGG GATTCAAATC 300

AGAGACGCTA CAGGCACGGG CGTGCTGCCT AAAATTTCGG TGCGCGGTTT TGGTGGGGGC 360

GGTAACGGGC ATAGCAACAC CAACATGATT TTAGTCAATG GTATCCCCAT TTATGGCGCG 420

CCGTATTCCA ATATTGAACT GGCGATTTTC CCTGTAACTT TCCAGTCAGT GGATAGGATT 480

GATGTGATTA AGGGGGGAAC GAGCGTCCAA TACGGCCCTA ACACTTTTGG AGGCGTGGTG 540

AATGTCATCA CTAAAGAAAT CCCCAAAGAG TGGGAAAATC AAGCGGCTGA AAGGATCACT 600

TTTTGGGGGC GCTCCTCTAA TGGGAATTTT GTCGATCCCA AAGAAAAAGG CAAGCCCTTA 660

GCCCAAACTT TAGGAAACCA AATGCTGTTT AACACTTATG GGCGAACGGC TGGGATGTTG 720

GGTAAATATA TAGGCATTAG CGCTCAAGGC AATTGGATTA ATGGGCAAGG TTTCAGGCAA 780

AATAGCCCTA CAAAGGTGCA AAACTACTTG TTGGATGCGA TTTATAAGAT CAATGCGACC 840

AATACTTTTA AAGCTTATTA CCAGTATTAT CAATACAACT CTTACCATCC AGGCACTTTG 900

AGCGCGCAAG ATTACGCCTA TAACCGCTTC ATCAATGAGC GCCCTGACAA TCAAGATGGA 960

GGGCGAGCCA AGCGCTTTGG GATCGTGTAT CAAAACTACT TTGGCGATCC GGATAGGAAA 1020

GTGGGGGGCG ATTTTAAATT CACTTATTTC ACGCATGACA TGAGTAGGGA TTTTGGGTTT 1080 TCCAACCAAT ACCAAAGCGT GTATATGAGC GGTCAAAATA AGATTTTACC CTTTAAAGGC 1140

AAGGGAGAAA TCAGCGCAAA AAACCCTAAT TGCGGTCTGT ATTCTTATAG CGACACGAAT 1200

AGCCCTTGCT GGCAATTTTT TGACAATATC CGCCGATCCG TGGTGAATGC CTTTGAGCCA 1260

AAACTCAATC TTATCGTCAA TACTGGTAAA GTCAAACAAA CTTTTAACAT GGGAATGCGC 1320

TTTTTAACTG AAGATTTATA CCGCCGATCC ACCACCAGGA AAAACCCTAG CATGCCTAAT 1380

AATGGGAGTG GGTTTGATGC AGGAACTTCA CTCAATAATT TCAACAATTA TACCGCTGTG 1440

TATGCCAGCG ATGAAATCAA TTTCAATAAC GGCATGCTAA CGATCACGCC GGGCTTGAGA 1500

TACACTTTTT TAAATTACGA AAAAAAAGAC GCTCCTCCCT TTAAGGTGGG TCAAACCCCA 1560

AAAACCACGA AAGAGCGTTA TAACCAATGG AATCCGGCAG TCAATGTCGG CTATAAACCC 1620

ATTAAAGAAT TATTGTTTTA TTTCAATTAC CAAAGAAGCT ACATTCCGCC CCAATTCAGC 1680

AATATCGGTA ATTTTGTAGG CACAAGCACG GATTATTTTC AAATCTTTAA TGTCATGGAA 1740

GGCGGCTCAA GATATTATTT TAACCATCAA GTGAGTTTTA ACGCGAACTA TTTTGTGATT 1800

TTTGCGAATC ATTATTTTAC CGGGCGCTAT GGGGACAACA GAGAGCCGGT CAATGCGAGA 1860

TCGCAAGGCG TGGAGCTGGA ACTCTACTAC ACGCCTATTA GGGGGCTTAA TTTCCATGCG 1920

GCTTACACTT TTATAGACGC TAATATCACA AGCCACACGA TGGTTACTAA CCCTGCTAAT 1980

CCTAAAGGGC CTAAAAAAGA TATTTTTGGC AAAAAGCTCC CTTTTGTCAG CCCGCACCAA 2040

TTCATTTTAG ACGCGAGTTA CACTTACGCT AAAACCACGA TTGGGTTAAG CTCTTTCTTT 2100

TATAGCCGCG CTTATAGCGA TGTGTTAAAC ACCGTGCCTT TTACAGAATA CGCGCCCACG 2160

ATTAAAAATG GGGCTATCGT TACCAAAACA GCGGGCATGA CGCCGTACTA TTGGGTGTGG 2220

AATTTGCAAA TTTCTACCAC TTTGTGGGAA CGCAAAAATC AAAGCGTGAA TGCGAGCTTG 2280

CAAATCAATA ACATTTTTAA CATGAAATAT TGGTTTAGCG GGATAGGCAC TAGCCCTAAC 2340

GGGAAAGAAG CTGCGCCTCC CAGGAGCATC ACAGCGTATG TGAGTTATAA TTTTTAA 2397

(2) INFORMATION FOR SEQ ID NO: 414:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 834 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...834

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 414:

ATGAAAACAA ACGGGCTTTT TAAAATGTGG GGGCTATTTT TAGTTTTAAT CGCTTTAGTC 60

TTTAACGCAT GCTCTGATAG CCATAAAGAA AAGAAGGACG CTTTAGAAGT CATTAAACAA 120

AGGGGGGTTT TAAAGGTGGG GGTTTTTAGC GATAAGCCTC CTTTTGGCTC TGTGGATTCT 180

AAAGGGAACT ATCAAGGCTA TGATGTAGTC ATCGCTAAAC GCATGGCCCT TGATTTATTG 240

GGCGATGAAA ATAAGATTGA GTTTATCCCT GTAGAAGCCT CAGCTAGGGT GGAATTTTTA 300

AAAGCCAATA AAGTGGATAT TATCATGGCT AATTTCACGC GCACTAAAGA AAGAGAAAAA 360

GTCGTGGATT TCGCTAATCC GTATATGAAA GTCGCTTTGG GGGTGATTTC TAAAGATGGG 420

GTCATTAAAA ATATAGAAGA GCTGAAAGAT AAAGAGTTGA TCGTGAATAA AGGCACGACA 480

GCGGATTTTT ATTTCACTAA AAATTACCCC AATATCAAAC TTTTGAAATT TGAACAAAAC 540

ACAGAGACTT TTTTAGCCCT TTTAAACAAT AAGGCCATCG CATTAGCCCA TGATAACACT 600

TTGTTGCTCG CTTGGGTGAA ACAACACCCT GAATTTAAAT TAGGCATTAC AAGCCTTGGC 660 GATAAGGATG TGATCGCTCC AGCGATTAAA AAAGGCAACC CTAAGCTTTT AGAGTGGTTG 720 AATAACGAGA TTGATTCCCT CATTTCTAGC GACTTTTTAA AAGAAGCTTA TCAAGAGACT 780 TTAGAGCCTA TTTATGGCGA TGGAATCAAA CCGGAAGAAA TTATTTTTGA ATGA 834

(2) INFORMATION FOR SEQ ID NO: 415.

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 624 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...624

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 415:

TTGGATAATT TCATCTCACA ATACGCGCAA CGCTTGATCG TAACCAATTT GAGTCAAGCG 60

ATTCGCATTT ATGGCTATGA AGTGGGTGGG ACTTTTAGAT ACAAGGGCGT GAGTTTGAAT 120

GTGGGGATCT CGCGCACTTG GCCCACCACT AGGGGGTATT TAATGGCGGA CAGCTATGAG 180

CTTGCCGCAA GCACCGGTAA TGTTTTTATC ATTAAATTGG ATTACACCAT TCCAAAAACA 240

GGGATCAATC TTGCATGGCT TAGCCGCTTT GTTACCGGTT TGGATTATTG CGGGTTTGAT 300

ATTTACTTGC CTGATTATGG GACAGCTGAA AAACCCAAAA CCCCTACCGA TTTAGCCAAA 360

TGCGGATCCC AATTGGGGTT AGTGCATATG CACAAACCGG GCTATGGCGT GAGTAATTTT 420

TATATCAATT GGAGCCCTAA AACCAAAAGC CACTGGAAGG GTTTGCTGCT TTCAGCCGTG 480

TTTAATAATG TTTTCAACAA ATTCTATGTG GATCAAACAA GCCCCTATGT CATGAGCCCG 540

GATATGCCAG GCACTGACGC TATTAAAAGA GCGATCGCAG AGCCTGGGTT TAATGCGCGT 600

TTTGAAGTGG CTTACAAATG GTAG 624

(2) INFORMATION FOR SEQ ID NO: 416:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 735 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi ) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE: (A) NAME/KEY: misc_feature

(B) LOCATION 1...735

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 416:

ATGAAAAAAG CGGGTTTTCT TTTTTTGGCG GCGATGGCTA TCATTGTTGT GAGTTTAAAC 60

GCCAAAGATC CGAATGTGTT GCGTAAGATT GTTTTTGAGA AATGTTTGCC TAATTATGAG 120

AAAAATCAAA ATCCTTCACC ATGCATAGAA GTCAAACCCG ACGCCGGCTA TGTGGTTTTA 180

AAAGATATTA ACGGTCCGTT GCAATATTTG TTGATGCCAA CGACTCACAT TAGTGGCATT 240

GAAAACCCTT TGTTGCTTGA TCCTTCTACG CCTAACTTTT TTTACTTGTC ATGGCAAGCG 300

CGCGATTTTA TGAGTAAAAA ATACGGAAAA CCCATTCCTG ATTATGCGAT CTCTTTGACG 360

ATCAATTCTA AAAAAGGGCG ATCGCAAAAC CATTTTCACA TCCATATTTC TTGCATTAGC 420

CTTGATGTGC GCAAACAGCT GGATAATAAT CTAAAAAATA TCAACAGCCG TTGGTCGCCA 480

TTATCAGGTG GCTTGAACGG GCATAAATAT TTGGCGCGTC GGGTAACAGA GAGCGAATTA 540

GCGCAAAAAA GCCCGTTTGT CATGCTTGCT AAAGAAGTGC CTAACGCGCA CAAACGCATG 600

GGAGACTATG GCTTGGCGGT GGTGCAACAG AGCGATAACT CCTTTGTCTT GTTAGCGACA 660

CAATTTAACC CATTGACTTT AAATCGCGCT TCAGCCGAAG AGATTCAAGA TCATGAATGC 720

GCGATTTTGC GTTAA 735

(2) INFORMATION FOR SEQ ID NO: 417:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 687 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...687

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 417:

ATGGTATTTG ACAGAACAAC AAGCGTAAGA GAAAAAAAAG CGGCTAAGGC GCTTGGGATT 60

GTGGGGATCG TCTTTTTTAT TTTGTTTGGC ATCGTGATAA GCGGGGTGGC TTCTCAAAAA 120

GAGTGGGTGC AACAATTGGA TTTATTTTTT ATAGACTTGA TCCGCAACCC TGCCCCCATT 180

CAAGGGAGCA CGTGGCTTTC TTTCGTGTTT TTTAGCACTT GGTTTGCGCA AAGCAAGCTC 240

ACCACTCCTA TAGCCTTACT CATTGGCTTG TGGTTTGGGT TTCAAAAACG CATCGCTTTG 300

GGGGTGTGGT TTTTCTTTAG CATCTTATTA GGTGAATTCA CCTTAAAATC CCTTAAGCTT 360

TTAGTGGCGC GCCCACGGCC TGTAACCAAT GGCGAATTGG TTTTTGCGCA TGGCTTTAGT 420

TTCCCTAGCG GGCATGCTTT AGCTTCAGCG CTTTTTTACG GCTCTTTGGC GTTGTTGTTA 480

TGCTATTCTA ACGCAAACAA TCGCATTAAA ACTATTGGTG CTATTATTTT ACTTTTTTGG 540

ATTTTTTTAA TGGCGTATGA TAGGGTTTAT TTAGGGGTGC ATTACCCTAG CGATGTTTTA 600

GGAGGGTTTT TATTAGGGAT TGCTTGGTCG TGCTGCTCTT TAGCGCTTTA TTTGGGGTTT 660

TTGAAACGCC CTTATAAAGC CGCTTAA 687

(2) INFORMATION FOR SEQ ID NO: 418: (l) SEQUENCE CHARACTERISTICS

(A) LENGTH 474 base pairs

(B) TYPE nucleic acid

(C) STRANDEDNESS double

(D) TOPOLOGY circular

(ii ) MOLECULE TYPE DNA (genomic)

(ill) HYPOTHETICAL. NO

(iv) ANTI-SENSE- NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...474

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 418:

ATGAAAAAAT TTGGTTTAGG GGTGTATTTG CTTCTTTTAG GTATTTTGGG CGGCTCTTTG 60

ATCATTCTAG GAGCGATAGT CGCGCCCATT GTTTTCAAAG CTTCAAGCAT TTTACCTGAA 120

TTGAATCTGA CTCCCTTTGA GAGTGGGAAA CTCATGGCGC AAATCTTTGT GCGTTTCAAT 180

TATGTTTTAG GCGCGATCGG TTTTGTGGTG TTACTTTATG AAATCATTTC GTTTATCTAC 240

TATAAAAGAT CGTTAGTGTA TTTGATCCTT GGCGTGGCGA TAGGGGCGTT GTGTTTGCTC 300

TTTGTTTTTT ATTACACGCC TTATATTTTA AACGCTCAAA AGGTGGGTGA AGTTGCGCTT 360

CAAAGTGCTG AATTTGCCCG CTCGCACGCT CAAAGCGAAT GGCTGTTTAA GGAATTGTTT 420

GTGCTGGTGT GTGCTTTGTT TTTTTGGCGT TTGTTTGGGA AAAATGCGCT TTAG 474

(2) INFORMATION FOR SEQ ID NO: 419:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 333 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi ) ORIGINAL SOURCE.

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...333

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 419:

TTGATCAATT TATTGCCCCA CCATTACCAT AAATTCCCCC CCAATATCAA CCCCTCTCTC 60

ATCTCTCTAA AAGATCGCTT TTTACCCCAT GAAAAGCACA GCCAAAAGGT CAAAAAAGAA 120

TGCGTCAACT TGTTTGAAGT TTTATCGCCT TTGCATAAAA TAGATGAAAA ATACCTTTTC 180

CATTTAAAGA TTGCGGGGGA ATTGGCGAGC ATGGGTAAGA TTTTAAGTGT ATATTTAGCC 240 CACAAGCACA GCGCGTATTT CATTTTAAAC GCTTTGAGTT ACGGCTTTAG CCACCAGGAT 300 AGGGCGATCA TTTGCTTATT GGGCGCAATT TAG 333

(2) INFORMATION FOR SEQ ID NO: 420:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 648 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...648

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 420:

ATGAAATCTT TTTTAAAACT TTTTGCACAG CCTTTGTTGG TGGTTTTAGC GTTCATGTTG 60

TTGTATGCTT TAGCGCATGC TGTGCTTGGT TTTTACGTGA AAAAAGACAG CGCTCCAATG 120

AGTCCAAATG TAGAAAAAAG CGAGACAGAG CGCCAAAACA GCACGTTTTC GCCTAAAGAA 180

GAAGCCAACG CAACCACAAC CGCCACAGAA CAAAACCCCA CCAAAGACAC AGTGCCACCT 240

TTAGACACAG CCACACAAAA ACAAGAGATT AAACAAGAGA TTAAACAAGA GATTAAACAA 300

GAGATTAAAC AAGAGATTAA ACAAGAGATT AAACAAGAGA TTAAACAAGA AACTAAACAA 360

GAGCAAGAAA AAGAAAATAA GCCTAAACAA AACAGTGTCT CGCCCGTTCA AAACGATCAA 420

AAAACCCCCA CAACCCCCTT AATGGGAAAA AAACCTCTAG AGTATAAAGT CGCAGTCAGT 480

GGCGTGAACG TGCGCGCTTT TCCTAGCACA AAAGGCAAAA TCATTGGCTC GCTTATAAAA 540

AATAAAAGCG TGAAGGTTTT AGAAATCCAA AACGATTGGG CTGAAATTGA ATTTTCTCAC 600

GAAACAAAGG GATATGTGTT TTTAAAACTT TTAAAAAAGG CTGAATGA 648

(2) INFORMATION FOR SEQ ID NO: 421:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 240 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature (B) LOCATION 1...240

(x ) SEQUENCE DESCRIPTION: SEQ ID NO: 421:

ATGTGGCCTG TGGCTCTCAA GCAGCCTAAT AGGGTGTCCC ATCATTTTTA TATCATGGCC 60

ATGCTTTTTA TTTTATTTGA TGTAGAAATC GTTTTCATGT TCCCTTGGGC GATTGATTTT 120

AAAAAGTTAG GCTTGTTTGG GCTCGTTGAA ATGCTAGGCT TTGTCTTCTT TTTGGCAATC 180

GGTTTTATTT ACGCTTTAAA GCGAAACGCT TTGAGCTGGC AAAAATTAGA GGTGAAATAA 240

(2) INFORMATION FOR SEQ ID NO: 422:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1251 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...1251

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 422:

ATGTGTGGGA TGTTTAAGAA TGAAATCAGC GCTATCCAAG GCATGATCGC TAACGCGCAA 60

GAAGCTGTCG CGCAAGCCAA AATCGTTAGT GAAAACACGC AAAATCAAAA CAGCCTAGAC 120

GCTGGAAAAC CATTCAACCC CTACACAGAC GCTAGTTTTG CTGAAAGCAT GCTCAAAAAC 180

GCGCAAGCCC AAGCGGAGAT TTTAAACCAA GCCGAACAAG TGGTGAAAAA CTTTGAAAAA 240

ATCCCTACAG CCTTTGTAAA TGACTCTTTA GGGGTGTGTT ATGAAGTGCA AGGAGGTGAG 300

CGTCGTGGCA CCAATCCGGG TCAGACGACT TCTAACACTT GGGGGGCAGG CTGTGCGTAT 360 GTAGGACAAA CGATAACAAA TCTTAAAAAC AGCATCGCCC ATTTTGGCAC TCAAGAGCAG 420 CAGATACAGC AAGCCGAAAA CATCGCTGAC ACTCTGGTGA ATTTCAAATC TAGATACAGC 480 GAATTGGGCA ACACTTATAA CAGCATCACC ACTGCGCTCT CTAATATCCC TAACGCGCAA 540 AGCTTGCAAA ATGCGGTGAG TAAAAAGAAT AACCCCTATA GCCCGCAAGG CATAGACACC 600 AATTACTACC TCAATCAAAA CTCTTACAAC CAAATCCAAA CCATCAACCA AGAACTCGGG 660 CGTAACCCCT TTAGGAAAGT GGGGATTGTT AGTTCTCAAA CCAATAATGG CGCGATGAAT 720 GGGATCGGTA TTCAGGTGGG TTACAAACAA TTCTTTGGCC AAAAAAGAAA ATGGGGCGCT 780 AGGTATTACG GCTTTTTTGA TTACAACCAT GCGTTCATTA AATCCAGCTT CTTCAACTCG 840 GCTTCTGACG TGTGGACTTA TGGCTTTGGA GCGGACGCTC TTTATAATTT CATCAACGAT 900 AAAGCCACCA ATTTCTTAGG CAAAAACAAC AAGCTTTCTG TGGGGCTTTT TGGGGGTATT 960

GCATTAGCCG GGACTTCATG GCTTAATTCT GAGTATGTGA ATTTAGCCAC CATGAATAAC 1020

GTCTATAACG CTAAAATGAA CGTGGCGAAT TTCCAATTCT TATTCAACAT GGGAGTGAGG 1080

ATGAATTTAG CCAGGCCTAA GAAAAAAGAC AGCGATCATG CGGCTCAGCA TGGGATTGAG 1140

TTAGGGCTTA AAATCCCCAC CATCAACACG AACTACTACT CCTTTATGGG GGCTGAACTC 1200

AAATACCGAA GGCTCTATAG CGTGTATTTG AATTACGTGT TCGCTTACTA A 1251

(2) INFORMATION FOR SEQ ID NO: 423:

(l) SEQUENCE CHARACTERISTICS: (A) LENGTH: 345 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...345

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 423:

ATGGCAACCA TTCAACCATT CAACCATTCA ACCATTCAAC CATTCAACCA TTCAACCATT 60

CAACCATTCA ATCATTCAAT CATTCAATCA TTCAATCATT CAACCATTCA AGCAACGCTA 120

CCTTATTTTT ATAACTATTT ATCTTTTTAC AAAAACCTAT TTAAAAATCC CCTATTTTTT 180

ATTATTCCCC CTTTTATTAA CCCTTTTATT AACCCTTTTA TTAACCCTTT TATTAACCCT 240

TTTATTAACC CTTTTATTAA CCCTTTTATT AACCCTTTTA TTAACCCTTT TATTAACCCT 300

TTTATTAACC CTTTTATTAA CCCTTTTATT AACCCTTTCA TATAA 345

(2) INFORMATION FOR SEQ ID NO: 424:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 381 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...381

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 424:

TTGGTTTCAG AATACTGGTT AAAATTCTTC ACGCGCTCTT TTTCTAAATC AACCATGCTC 60

TTTAAAACCC TCTTGCGGTC TTTTTTCACA TTCCCTGTGG AGCTTTCAGA AAACATAACA 120

TTGGGATCAA CTGTAGTGTT AATAGTAGCA GAAGCCGTTT CTGCTCTCAA CAAAAAAGTC 180

GTAGCCGCTA AAAAAAATAA AATTCGCTTC ACACCAAACT CCTATATCCA TAACCGCAAC 240

AAAAACAGAC GCTATTCTTC ATTAAGCCCT CTTTTAAAAT CTTCTTCTAT TTATAAAAAC 300

CCACCTAGAA TTCAAGCTAT TTTGATTATC TTAAAATACA GACTTTCAAA GGGTATTTAT 360

CATTTGGGTA TGATACTATA A 381 (2) INFORMATION FOR SEQ ID NO: 425:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 861 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...861

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 425:

ATGAAGAAAT CTGTTATAGT AGGTGCTATC TCTCTAGCAA TGACAAGCTT ATTGTCAGCA 60

GAGACCCCTA AGCAAGAAAA GGCTATTAAG ACTAGCCCTA CCAAAAAAGG TGAAAGAAAT 120

GCTGCTTTTA TAGGGATTGA TTACCAGTTG GGTATGCTCA GCACTACCGC TCAAAATTGT 180

TCCCATGGGA ATTGCAATGG TAATCAAAGT GGGGCTTACG GCTCTAATAC GCCTAACATG 240

CCTACAGCGT CAAACCCAAC AGGAGGCCTT ACTCATGGCG CTCTAGGGAC TCGTGGGTAT 300

AAAGGCTTAA GCAACCAACA ATACGCTATC AATGGTTTTG GGTTTGTTGT AGGGTATAAG 360

CATTTTTTTA AGAAAGCCCC ACAATTTGGA ATGCGTTATT ACGGATTCTT TGATTTTGCA 420

AGCTCTTATT ATAAGTACTA CACTTATAAT GATTATGGCA TGAGAGACGC TCGCAAGGGT 480

TCTCAAAGTT TCATGTTTGG CTATGGGGCT GGCACAGATG TGTTGTTTAA CCCAGCTATT 540

TTCAATCGTG AGAACTTGCA TTTGGGGTTT TTCTTGGGCG TTGCGATTGG TGGCACCTCT 600

TGGGGTCCAA CAAACTATTA TTTTAAGGAC TTAGCTGAAG AGTATAGAGG GAGTTTCCAC 660

CCATCAAATT TCCAGGTCTT AGTTAATGGC GGGATCCGCT TAGGCACTAA ACACCAAGGT 720

TTTGAAATTG GCTTGAAAAT CCAAACCATT CGCAATAATT ACTATACCGC TAGCGCGGAT 780

AATGTGCCTG AAGGGACTAC TTATAGATTC ACTTTCCACC GCCCTTACGC CTTTTATTGG 840

CGTTACATTG TAAGCTTTTA A 861

(2) INFORMATION FOR SEQ ID NO: 426:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 858 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori ( ix ) FEATURE :

(A) NAME/KEY: misc_feature

(B) LOCATION 1...858

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 426:

GTGAAGCGAA TTTTATTTTT TTTAGCGGCT ACGACTTTTT TGTTGAGAGC AGAAACGGCT 60

TCTGCTACTA TTAACACTAC AGTTGATCCC AATGTTATGT TTTCTGAAAG CTCCACAGGG 120

AATGTGAAAA AAGACCGCAA GAGGGTTTTA AAGAGCATGG TTGATTTAGA AAAAGAGCGC 180

GTGAAGAATT TTAACCAGTA TTCTGAAACC AAGATGAGTA AGGGCGATTT ATCCGCTTTT 240

GGAGCTTTCT TTAAGGGGAG TTTGGAAGAT TGCGTGGAGC AAAAGATTTG TTACTATGAG 300

CATAGGAATG GCAAGGTTTC TTTTGTGGTG AATGACAGAG AAAAGTTTTA TAAGCATGTG 360

CTTAAAGACT TAGGGACAGA GCTTTCACTC CCCTTGTTCA ACTGGCTTTA CAAAGGCTCA 420

GATTTTGGGG CTTTGCATGA GCAGTTTGGG GACATGTATG ATGGGTATAT CAAATACTTG 480

ATCAGCATGG TTAGGGTGAG CCAAAAAGAA AAGGCTAGAA AAGTGGATGC AATCGTTCTT 540

AAAAAAATGG AAGAACAAGC TGAGAAAGAC ACTAAGGCAG CATTCCAAAA GAGGAGCAGT 600

GGGGAGCTTG AAAGCCATAC TGATAGCCCT GAATTTATAA GCTCTTCTAA GACACAGAAT 660

TCTTCTAACC CAGATCTAGA CCCTATGACT AACGCTAACA CGCTCAAAGA AACAGCTTCA 720

AAAGAGCCAG AGACTTCTTC AAAAAAGGAA AAAAAGCCCA AGAAAAAACG ACGCCTTTCA 780

AAGAAAGAAA AGCAACAACA GGCCTTACAA CAAGAGTTTG AAAAGCAAAT TAGCGACTCT 840

AGTAAGTCTG AAAAATAG 858

(2) INFORMATION FOR SEQ ID NO: 427:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 228 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...228

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:427:

ATGCCAAAAG AAAACACCAC CCACGAAGAC GCTTTAGCGA AATGCTTTGC GCCTGCAATT 60

TTTAAAGCCA TCATGCTGAA TAAATTGATA TTGGCGGTTG TGGCTGCTCC CATTATAAAG 120

ATGCTTAAAT TGAGTAAAGA GATTTGGTGG AAAAAAATGG GCAAAAAACA TGCGATAGAT 180

TTTAAAATGA GGATAAAGAT ATTGGCTTCT TTAGCCCCTA GCTTTTGA 228

(2) INFORMATION FOR SEQ ID NO: 428:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 405 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular (11) MOLECULE TYPE. DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE. NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...405

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:428:

ATGTGCCAAA TCCAATGCTT GCTTATTTTG CTTTCTATCA ATATAGTTAG CGCGATTATC 60

GTTTATTTTT TCCAAGCATT TCAAGGGGTT TTGAATTTTG AAGGGGGGTT TTTAGGGTTT 120

TTTATCGTGG CGTTGTCTTC GTATTACGGC GTTAAAAAGC GTTTGGATTT GAGGAAACAA 180

GATTCAAAAG AAAAAGAAGA AAAGCAAAAA TTCCAAAAAT TCGCCCTAGG TTTGGAAATG 240

TCTTTCAATG TGTGGCGTTT AGGGGGGTAT GGGGTTTTAT TAGGTATTTT AGGAGTGCTT 300

TTATTCTTGC ATCTTTTTAA CGGATTGCCG TTTCTTATCG GCGTGTTTGT GAGCTCGCTC 360

TCTAGCGCGT TATTACGATT CTTAAACAAT AATGGTAAGT TTTGA 405

(2) INFORMATION FOR SEQ ID NO: 429:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 279 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_£eature

(B) LOCATION 1...279

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 429:

ATGGCGTGTG AATTTTTGAA AAAGCCAAAG TATTACAAGT TTATAGAGGG GGCGAATTAT 60

TTGAGCTTAG GGCTTTCTAT GGTGGTGGCG ATCCTTATGG GCGTGGCTAT AGGCTATGGG 120

CTTAAAAAAC TCACTCACAT TTCGTGGCTT TTTTGGCTTG GGGTTATTTG GGGCGTGTTA 180

GCGAGCTTTC TCAATGTCTA TAAGGCTTAT AAAAACATGC AAAAAGACTA TGAAGAACTA 240

GCCAAAGACC CTAAATACAC GCAAAATAAA ACAAAATAA 279

(2) INFORMATION FOR SEQ ID NO: 430:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 240 base pairs (B) TYPE, nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(11) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...240

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:430:

ATGGAAGACT TTTTGTATAA CACCTTATAT TTCATAGAGG ATTATAAGTT GGTTGTTATT 60

TTTAGTTTCA TAGGGTTAAT AGCGTTATTT TTCCTCTACA AATTCATAAA AACTCAAAAA 120

AAGGTTTTTA AAGATAAAGC TAACCAGCCT CAAAAGAAAA AAAGCTTTAA AGAAATCATT 180

ATAGATGGGC TGAAAGAAAG GGTTAAAACC TTTGGCTTTA GGTTGCAAGC TATACTATTA 240

(2) INFORMATION FOR SEQ ID NO: 431:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1092 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...1092

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:431:

ATGGCCATTG ATTTAGCAGA AGTTACAGGA GCTAAAGCCG CGCAAGAAAG GAAAAAAGAA 60

CAGCCCACCA TCGCTAACGG GTTGGATAAA AACGCTTTCA TGAAACTCTT TTTAGAGCAA 120

TTGAAAAATC AAGACCCCAC CGCTCCTATG GAAACGGATA AAATCATCAC CCAAACCGCG 180

CAACTCACGC AAGTGGAAAT GCAAGAAGAA AACAAAAAGA CCATGCAAGA AGTCGCCAGT 240

GCGATGAAAT CCAATAAAGA AACTAACGAA TCTTTAAAAG ACTTTCAAGG CGCTTTAAAA 300

GACACCATGG AAAACCTGAA CAAAGGCATG GACGATAGCT TAAAGGCTAA CAACGCTTTA 360

AGGGAAGTAA GCGCCCTTAA TTCTGTGAGC ATGATAGGCA AAATCGCTGA AACCGATGTG 420

AGTGGGGCGA ATTTTGACGG CAACAACAAG CTTTCTTTTT CGCTCTTTTT TGATGAAAAA 480

ATTGACGCTT CTAAAGGAGT GCCAGCGATT CAAATCTTAA ACGAAAACAA TGAATTGGTC 540

AAAACGATTC CTTTAAAAGA TTATAACGGG CAAAAGGGGT ATATCAATTT TGAATGGGAC 600 GGCACAAACG AAAAGGGCGA AAAAGTCCCT AAAGGCAATT ACAAAATCAA GGCTGAATAC 660

AATTTAGACT CTCAAAGCAA GCAGTATTTG CAAACGCGCA TTGGTAGGGG CGAAGTGGAA 720

AGCGTGATTT TTGATAAAGG CAAACCCATG TTAAGAATGG GCGAAATGAT TTTACCCATA 780

GACAGCGCGA TAGAGTTTTA CAAACCGGAT CAAAAACCGC TTGATCAAAA ACTCTCGGAT 840

CAAAAACCTC AAAAACTCTC TGAACAAAAA GCCCTTGAAC AGAAAATCTC TGAACAAAAA 900

CCGCAAGAAC CCCTTGATCA AAAACTCTCG GATCAAAAAC CACAGAAACC GCTTGAACAG 960

AAAATCTCTG AACAGAAACC GCTAGATCAA AAACTCTCGG ATCAAAAACC ACAGAAACCG 1020

CTTGAACAGA AAATCTCTGA ACAGAAACCG CTAGATCAAA AACCCCAAAC CCCCCCTAAA 1080

GAGACAGCAT GA 1092

(2) INFORMATION FOR SEQ ID NO: 432:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 654 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...654

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:432:

TTGAAACATT TAGCCCCACT CATTCATATC CCTTTTAAAG CCTTATGGCT AGGCACAGCC 60

TTAAGCATGT TCTTAAGTTT GAATTTGAAC GCTGAAGAAA ACCCTACTAA AACAGAGCCT 120

AAGCCCGCTA AAGGGGTTAA AAACAAGCCC AAATCGCCTG TTACTAATGT CATGATGACC 180

AATTGCGATA ACCTTAAAGA CTTTAACGCT AAGCAAAAAG AAGTTTTAAA AGCCGCTTAT 240

CAATTCGGAT CTAAAGAAAA TTTAGGCTAT GAAATGGCGG GCATTGCGTG GAAAGAATCA 300

TGCGCAGGGA CTTATAAAAT CAATTTTTCG AATCCGAGTG CGGGCATTTA CCATGCGTAT 360

ATCCCTAGCG TTTTAAAAAG CTATGGGCAT AATAATAGCC CCTTTTTGCG TAACGTGATG 420

GGGGAATTGC TCATTAAAGA CGATGCGTTT GCTTCTGAAG TGGCCCTAAA AGAATTGCTA 480

TATTGGAAAA CGCGCTACCA TGACAACCTA AAAGACATGA TCAAGTCTTA CAATAAGGGC 540

AGTCGTTGGG AAAAAAACGA GAAAGCTAAC GCTGATGCTG AAAAATATTA TGAAGAGATA 600

CAAGATAGAA TCAGGCGTTT GAAAGAATCT AAAATCTTTG AACTCGCAGT CTAG 654

(2) INFORMATION FOR SEQ ID NO: 433:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1101 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1101

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 433:

ATGCAATTTC AAAAAACCTT ACTTTCTTTA TCTTTATTAT TTTTATCTTA TTGTATCGCT 60

GAAGAAAATG GGGCGTATGC GAGCGTGGGT TTTGAATATT CCATCAGTCA TGCCGTTGAA 120

CACAATAACC CTTTTTTGAA TCAAGAACGC ATCCAAACGA TTTCTAACGC TCAAAACAAA 180

ATCTATAAAC TCAATCAAGT CAAAAATGAA ATCACAAACA TGCCCAACAC CTTTAACTAC 240

ATCAACAACG CTTTAAAAAA CAATGCTAAA TTAACCCCTA CTGAAAAGCA AGCCGAAACC 300

TACTACCTGC AATCTACCCT TCAAAACATT GAAAAAATAG TCATGCTTAG CGGGGGCGTT 360

GCGTCTAACC CTAAATTAGC CCAAGCGTTA GAAAAAATGC AAGAACCCAT TACTAACCCT 420

TTAGAATTGG TAGAAAACTT AAAAAATTTA GAATTACAAT TCAGCCAATC TCAAAACAGC 480

ATGCTTTCTT CTTTGTCTTC TCAGATCGCT CAAATTTCAA ATTCTTTGAA CGCGCTTGAT 540

CCCAGCTCTT ATTCTAAAAA CGTTTCAAGC ATGTATGGGG TAGGTTTGAG CGTAGGGTAT 600

AAGCATTTCT TTACCAAGAA AAAAAATCAA GGGTTTCGTT ATTACTTATT CTATGACTAT 660

GGTTACACTA ATTTTGGTTT TGTGGGTAAT GGCTTTGATG GTTTAGGCAA AATGAATAAC 720

CACCTCTATG GGCTTGGCAT AGATTATCTT TTCAATTTCA TTGATAATGC GCAAAAACAT 780

TCGAGCGTGG GGTTTTATGT AGGCTTTGCT TTAGCGGGGA GTTCGTGGGT AGGGAGTGGT 840

TTAGGCATGT GGGTGAGTCA AATGGATTTC ATCAACAACT ATTTGACGGA TTATCGGGCT 900

AAAATGCACA CGAGTTTTTT CCAAATCCCT TTGAATTTTG GGGTTCGTGT GAATGTGGAT 960

AGGCACAATG GCTTTGAAAT GGGCTTAAAG ATCCCTTTAG CGGTCAATTC CTTTTATGAA 1020

ACGCATGGCA AAGGGTTAAA CGCTTCCCTC TTTTTCAAAC GCCTTGTCAT GTTTAACGTG 1080

AGTTATGTTT ATAGTTTTTA G 1101

(2) INFORMATION FOR SEQ ID NO: 434:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1101 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1101

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 434:

ATGCAATTTC AAAAAACCTT ACTTTCTTTA TCTTTATTAT TTTTATCTTA TTGTATCGCT 60 GAAGAAAATG GGGCGTATGC GAGCGTGGGT TTTGAATATT CCATCAGTCA TGCCGTTGAA 120 CACAATAACC CTTTTTTGAA TCAAGAACGC ATCCAAACGA TTTCTAACGC TCAAAACAAA 180 ATCTATAAAC TCAATCAAGT CAAAAATGAA ATCACAAACA TGCCCAACAC CTTTAACTAC 240

ATCAACAACG CTTTAAAAAA CAATGCTAAA TTAACCCCTA CTGAAAAGCA AGCCGAAACC 300

TACTACCTGC AATCTACCCT TCAAAACATT GAAAAAATAG TCATGCTTAG CGGGGGCGTT 360

GCGTCTAACC CTAAATTAGC CCAAGCGTTA GAAAAAATGC AAGAACCCAT TACTAACCCT 420

TTAGAATTGG TAGAAAACTT AAAAAATTTA GAATTACAAT TCAGCCAATC TCAAAACAGC 480

ATGCTTTCTT CTTTGTCTTC TCAGATCGCT CAAATTTCAA ATTCTTTGAA CGCGCTTGAT 540

CCCAGCTCTT ATTCTAAAAA CGTTTCAAGC ATGTATGGGG TAGGTTTGAG CGTAGGGTAT 600

AAGCATTTCT TTACCAAGAA AAAAAATCAA GGGTTTCGTT ATTACTTATT CTATGACTAT 660

GGTTACACTA ATTTTGGTTT TGTGGGTAAT GGCTTTGATG GTTTAGGCAA AATGAATAAC 720

CACCTCTATG GGCTTGGCAT AGATTATCTT TTCAATTTCA TTGATAATGC GCAAAAACAT 780

TCGAGCGTGG GGTTTTATGT AGGCTTTGCT TTAGCGGGGA GTTCGTGGGT AGGGAGTGGT 840

TTAGGCATGT GGGTGAGTCA AATGGATTTC ATCAACAACT ATTTGACGGA TTATCGGGCT 900

AAAATGCACA CGAGTTTTTT CCAAATCCCT TTGAATTTTG GGGTTCGTGT GAATGTGGAT 960

AGGCACAATG GCTTTGAAAT GGGCTTAAAG ATCCCTTTAG CGGTCAATTC CTTTTATGAA 1020

ACGCATGGCA AAGGGTTAAA CGCTTCCCTC TTTTTCAAAC GCCTTGTCAT GTTTAACGTG 1080

AGTTATGTTT ATAGTTTTTA G 1101

(2) INFORMATION FOR SEQ ID NO: 435:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 525 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...525

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 435:

TTGAATACAA TGAATAGCGT GTTAGAATGT AAAGAATTAG CGCTCTATGG AGGGAGTTTT 60

GATCCTTTGC ACAAGGCTCA TTTAGCCATT ATTGAGCAAA CTTTAGAATT ATTGCCATTC 120

GTTCAGCTGA TTGTCTTGCC CGCTTATCAA AACCCTTTCA AAAAGCCATG TTTTTTGGAC 180

GCAAAAACCC GTTTTAAGGA ATTAGAAAGA GCTTTAAAGG GAATGCCTAG GGTGCTGTTG 240

AGCGATTTTG AAATCAAGCA AGAAAGGGCT GTGCCTACGA TAGAAAGCGT TCTTCATTTC 300

CAAAAACTCT ACCGCCCTAA AACGCTTTAT TTAGTCATAG GAGCGGATTG TTTGAGGCAT 360

CTTTCTTCTT GGACTAACGC TAAAGAGCTT TTAAAAAGGG TGGAATTAGT GGTTTTTGAA 420

AGGATTGGCT ATGAAGAAAT TCAATTTAAG GGGCGTTATC ACCCTTTAAA AGGCATTGAC 480

GCGCCGATTT CTTCTAGCGC GATTAGGGCT AGTTTAGGGG TTTAA 525

(2) INFORMATION FOR SEQ ID NO: 436:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1131 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular (11) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE. NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...1131

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 436:

ATGAGATTTT TTTGCTTCTT TTTATTTTTT CTAACCTTTT CAAACGCGCA GATAATGATG 60

ACTTTTGATT CCCAAACTAA CGCCAAACTT TCGCGCTCCA ACGAACAGCT TTCTGACATG 120

CTTTACAAAC TCAATGAAAG TTTAAGAATC TATCAAAACG TGCTTTCTAA CAACCAGGAT 180

CAACTTAAAG AAATCAAAAA GGCTAACAGC ACCCTAACTA GCCAAAGGCG TTTTTTTAAC 240

GCTAGCCAGA TCCGCCTTAT GGACACTGAT GCACTATTGA AACAAAGCGC TTTGGAATTA 300

GAAAAATTAC AAGCTTTAGA AAAACACTTA AAAGAGAGCA TGGAGCATGA ACGCTTAATC 360

AAAGAATCCC AAGCGCTTTT TTTGCAAGAG CATTGCCCTT ATTTGAGCGG CGTTAAGAAT 420

TTAGAAGAGG CATCAAACGC TTTAGAAGTC CAAGAAAAAA ATAACGCCCT TTTCTTACTC 480

AAAGAGCCTA AACTCTTTCA TTTGCTCTCA CGATTGGATT TGATGAGCGC TTTAAACGCC 540

TTATGCGATC AGGTTTTAGA AAATGAAATA CAGGATCAAC AATCCCATAA CAAAACCCTA 600

GAATACAACG CCCTTATGAA CCATGATTTT CAAGCCTATA AAGCCATGCG TTTGAAAAAA 660

ATTAAAAACA AGCTTCAAAG CCAAATCCAA GCTAAAGAAG ACGCCCTAAA AACCTTTTTA 720

CCCCTAGAAA AACGCCTAGA AACTTTAAAA TCGCGCTTTT TATGCGACAA AGAAAATCTC 780

AAATCATGCG CTAACCAATT ACAGCAACGC TACCAAAACG CCCTAATAGA GCGAGATAAG 840

GAATTAAAAA ACGCTAAAAA CAACAAAGAA AAGCATGCTC TAATCTTAGC CAATTACGAA 900

CACACTTTAA AAACCTTGAA TATAGAATTT TTAAGCGAAT TGAGTGAGCA AATGGCGTTT 960

TTGAATGAGA CCATGGCGTT AAACGCCCAA GTTTTAGCCC TTTTAGCCCA ACAACAGACT 1020

AAAAAGCCCT TCAATGTGAG CGATGGTTTG AGCGGTGGGA AAGCCCTTAT TAAAAATATC 1080

CGCTTAGATC CGCATGGATT CCCTAGCTTT AAAAATTTTA AGCAAGAGTG A 1131

(2) INFORMATION FOR SEQ ID NO: 437:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 690 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...690 (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 437:

GTGAAAGGCG AGAAAAACGC TTGGTATCTG GGGATTAGCT ATCAAGTCGG TCAGGCTTCA 60

CAAAGCGTTA AAAACCCCCC CAAAAGCAGT GAATTTAACT ATCCTAAGTT CCCTGTGGGT 120

AAAACCGACT ATCTGGCCGT TATGCAAGGC TTAGGGCTTA CTGTGGGTTA TAAGCAGTTT 180

TTCGGGGAGA AAAGATGGTT TGGTGCGCGC TATTACGGCT TTATGGATTA TGGGCATGCC 240

GTGTTTGGAG CGAACGCTTT GACATCAGAT AATGGTGGGG TGTGCAAACT CAATGAGCCA 300

TGCGCGACCA AAGTAGGGAC TATGGGCAAT CTGTCTGACA TGTTCACTTA TGGTGTGGGT 360

ATTGACACTT TATACAATGT CATTAATAAG GAAGACGCGA GTTTTGGTTT CTTTTTTGGG 420

GCTCAAATCG CGGGTAACTC TTGGGGTAAT ACGACAGGGG CCTTTTTGGA AACTAAAAGC 480

CCTTATAAGC ACACCTCCTA TAGCCTTGAT CCGGCGATTT TCCAGTTCCT TTTTAATTTA 540

GGGATTCGCA CCCATATTGG TCAGCATCAA GAATTTGACT TTGGCGTGAA GATTCCTACT 600

ATCAATGTTT ATTATTTTAA CCATGGGAAC TTGAGCTTCA CTTACCGCCG TCAATACAGC 660

CTTTATGTAG GGTATCGTTA CAATTTCTGA 690

(2) INFORMATION FOR SEQ ID NO: 438:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1440 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1440

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 438:

TTGAAAAACC ACTCCTTTAA AAAAACGATC GCTCTTTCCT TGCTGGCGAG CATGTCTTTG 60

TGTAACGCTG AAGAAGATGG GGCGTTTTTT GTCATTGATT ACCAAACGAG TTTGGCCAGA 120

CAGGAATTGA AAAATCCAGG CTTCACTCAA GCGCAAGAAT TAAAGCAACT CATTAGAGAT 180

GGGGCTGTGA GGTTGCAAAC TTCTGCCATT CCCTTATCCT ACTACTTGGA TATTTTAGGG 240

AATAAAACAA AAACTCTTTT GAGTGAAAGC CTAAAAAACA ATCCGCAACA ACCAAACGGG 300

CAACCCAACC AAGCTTTAGT CAATTTAGAG CAATCTCTAG GGATTTTAGG AAAACTACTA 360

GATCTATCCC AACAATACGC TTCAGAAGGT GTCATTAAGC CTTTGGTGGT GGATGTAGGG 420

AAAGAACAAA TCGGTATCAC GGATAGCATG CTCTTGGTGG CTCAAAACAT CGTTTTAGCT 480

TTAGGGCAAG TGGATTTGAG CAAAATCCAA CAAAACAATG GTAACCAACA GCTATACGAA 540

AACATCATGA AAGTCATGCT TTTAGGCACA GGCGGGACTA ATGGAGCGTA TAATGGCGTG 600

AGTGTGGGCG ATATCGCCAC AGGCATGCAA AATTTTCCTT CGCAAACGGG CTTGATTGGG 660

GCTAATTCTA CGGTGAGCGA GCTCAACGCT TTGATTAAGA GCGGGATTTC TTTAGATCGT 720

GAAACTTTGG GGTTAGGGAG TTTTATTGAA AAAAATATCT GCAGCGGTGC ATCGTCTTGT 780

TTTAGTGGGA ATCAGCTTAT CTATAAGAAA GGGCTAGACA GAACCATAAA CATCATTAAT 840

GCGGTATTAG GTCAGTTTGA ATCTTCGGCT AGTTCTCTTT ATAAGATTTC TTATATCCCT 900

AACCTCTTTT CGCTCAAAGA TTACCAGTCA GCGAGCATGA ACGGCTTTGG GGCTAAAATG 960

GGTTATAAAC AATTTTTCAC CCATAAGAAA AATATCGGCT TAAGGTATTA TGGGTTTTTG 1020

GATTATGGCT ATGCGAATTT TGGCGATACG AATTTAAAAG TGGGAGCGAA TCTTGTTACT 1080

TATGGGGTAG GAACGGATTT TTTATACAAT GTGTATGAAC GCTCTAGAAG GAGAGAAAGG 1140 ACTACAATCG GTCTTTTCTT TGGCGCTCAA ATTGCAGGGC AAACTTGGAG CACTAATGTA 1200

ACGAACTTAT TGAGCGGGCA AAGGCCTGAT GTCAAGTCCA GTTCGTTCCA ATTCTTATTT 1260

GATTTGGGCG TGCGCACCAA CTTTGCAAAA ACCAATTTCA ATAAGCACAG ATTAGACCAA 1320

GGGATAGAAT TTGGGGTGAA AATCCCTGTT ATCGCTCATA AATATTTTGC AACCCAAGGC 1380

TCAAGCGCGA GCTATATGAG GAATTTTAGC TTCTATGTGG GCTATTCAGT CGGTTTTTAA 1440

(2) INFORMATION FOR SEQ ID NO: 439:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 540 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...540

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 439:

ATGGCGTCTC TTGCCTTTGT TCAAGCTTTT TTGGAGTCTT TTAAGGGATT TTTAAGCCAA 60

GCGACCTTAA TTAGCGTTTT AATAGCGAGC GTTTTAATCC TTTTTTGCGC GATTTTGCTC 120

CTTTTGGCTC TGCTTTTAAG AAACCGCTGG GCTAGTTATA TAACAACAGC AGCTTTTTTG 180

GGCGCGTTTT TAAGCATGCC TTTTGTTTTG AACGTTTTAC TCACTCAAGC GATTTACCCC 240

ATAGAAACGC GCATCTTGCA CGCTAATCCC TTAAGTTATA GCAACGCCTT TTCTTTGCAA 300

GTGGGAGTCA AAAACATTTC CAAATTCAGT CTAAACAAAT GCGTTTTACG CCTAGAAGTC 360

CTTAAAAACC CTCACAATTT TGTGGAAGAG CGAGCTTTTA AATGGTTTGT CAAAAAAAGC 420

TATGAAAAAA CCTTTAAAGA AAAGATTTTG CCTGAAGAAT CCAAGGTCTT TTCATTCTTT 480

ATTGACGACT ACCCTTATTC AAAAACGGCC CCTTATCAAG TTTCTTTGTT TTGTTTGTAG 540

(2) INFORMATION FOR SEQ ID NO: 440:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 390 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE: (A) NAME/KEY: misc_£eature

(B) LOCATION 1...390

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 440:

TTGGGGGAGT TGCTGCAAGC TAGCGCACCT TATGCGATCG CTCCTGTGGA GTTGATCGTT 60

GTTTTTTATA AAAACGAATA CAAACGAAAA AAACAAACTT CTACGATGAG TAGAGAGGAA 120

TTTTTACTCT ACACGAACGG GCTTTGGAAT TTTAGCGGTG AATCCAAAAA GCGCCTAAAG 180

CACCCAGCCC CATTCCCAAG GGAATTACCC AGGCGTTGCA TCCAATTGTT TTCTTTTTTG 240

GAAGACACGA TTTTTGATCC CTTTAGCGGC TCTGGCACGA CTATTTTAGA GGCCAACGCT 300

TTAGGGCGTT TTAGCGTGGG TTTAGAGATT GAAAAAGAAT ATTGCGAGTT GTCTAAAAAG 360

CGTATTTTAG AGAGTTTGTC GTTAGTGTGA 390

(2) INFORMATION FOR SEQ ID NO: 441:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 984 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...984

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 441:

GTGCTTAAGG GGTTAAAAAA AGCGTTTAAG GAGAGGTTTT GCTCTCAAGT GTATATCTCT 60

TTTAATGTGG ATCACAATCT TTTATCCGCT CAAGTTTTAA GGGTTAAAAA CCACCGCATC 120

AAAGAGAAAT TTTTTAAAAC TTTTGAGACT AAAGTGGAAA CTAAAAATGG TGAAGTCCCC 180

ATTCAAGCCT TAAAAATCGC CAGAACTTAT AGCCAAAAAT ACCCCTACAC CTATTTTAGC 240

GCGATGAGTA AAGCTAAAGA GGTTTTATGC GAAAAGCAGG CGTTTGAACA AATCAAACAA 300

GAAAATCAAG ATTATCAGGC TTGTGAAGTC AATCAAAAGT ATTGCGTTTA TGTGGAATCT 360

AAGGATTTTC TAAAGGATTT CAAGCGTTTT AAAATCCAGG ATGTGGATTT TTTGTTTTCG 420

CCCTTTAGCC TTATTTATGA TTTTGTGCGC GATAATTTAG AAAACAAGCC GTTGTTGTAT 480

CTGCTTTTAG AGCGTTCAAG GTTTTATTTT TTGATTGCGG ATAAAAAAGA GATTTTTTTA 540

GCCAAATCCG TGTTTTTAGA AGAGCAACCT GAAGAGTTTA TAGAGAGCAA AGAAGAAGAT 600

TCTATGGGAA TGGATAATGA AGCTGTGGAT TTGTTTTTGA GTGAAATCCA AGAAGATATT 660

GACAGCCTTG AAGAAGCGAT AGGCCTAGAC AGCAGCAAGG ATAATAGCGA AAAAATAACA 720

GAGGACGCTT ATAGTTTGAT TGAAGGCATG ACGAATATCC CCTTGATTGC AGATGTTTTG 780

CAAGAGGGAT TGCGTGGCGT CTATCATTCT AGAGAGATAG ACTTTGTAGA AAAAGTGGTT 840

GTTTTAGACA GCTGTCAAAT CCACCACAAG GCGTTAATGC ATTTGCAAGA AACTTTGATG 900

ATAGAAGTGG ATAGGCTCGA TTTTTCTTTA GTGGAGCGGT TGAATGTTTT AGCGCGCATG 960

GAGAATGAAA AGCATGCGTT TTAG 984

(2) INFORMATION FOR SEQ ID NO: 442:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1296 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1296

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 442:

ATGAATATTC AAACAAAGAA AAGATTTTTA GCAAATTTAT TGCTTTTTAG CCTGTTTTCT 60

TGCCTTAAGG CTGAAACCCT TTCAGAAGAC CATCAAATCC TGTTGAGTTC AGACGCTTTC 120

CATAGAGGGG ATTTTGCCAC CGCTCAAAAA GGCTATATGA ATCTCTATAA GCAAACCAAT 180

AAAGTGGTGT ATGCTAAAGA GGCGGCCATT TCAGCGGCGA GTTTAGGGGA CATTAAAACC 240

GCTATGCATT TAGCCATGCT TTATCAAAAA ATCACCAATA ATCGTAACGA TGTTTCTATC 300

AATAAGATTT TAGTGGATGG CTATGCACAA ATGGGGCAGA TTGATAAGGC GATTGAACTA 360

TTACACAAGA TTCGTAAGGA AGAAAAAACC ATAGCCACAG ACAATGTGTT AGGGACTTTG 420

TATTTGACTC AAAAGCGTTT GGATAAGGCT TTCCCGTTGT TGAATAAGTT TTATAACCAA 480

GTGCATGATG AAGACAGCCT AGAAAAACTC ATTACGATCT ATTTTTTACA AAACCGCAAA 540

AAAGAGGGTT TGGATCTGTT GCAATCTCAT ATAGACAGGT ATGGTTGCTC AGAGCAATTG 600

TGCCAAAAAG CGCTCAACAC CTTCACGCAA TTTAACGAGC TTGATTTGGC TAAAACGACT 660

TTCGCTCGTT TGTATGAAAA AAACCCTATT GTTCAAAACG CCCAATTTTA CATAGGGGTA 720

TTAATCTTGT TAAAAGAGTT TGATAAGGCC CAGCAAATCG CAGAATTATT CCCCTTTGAC 780

AGGCGTTTGT TGCTAGACTT ATACACCGCG CAAAAAAAAT TTGATCAAGC TTCCAAACAG 840

GCTTCTTTAA TCTATCAAGA AAGAAAAGAC CCTAAATTCT TAGGCTTAGA GGCGATTTAT 900

CATTATGAAA GCTTGAGCGC GAATAAGAAA AAGCTCACCA AAGAAGAGAT GTTGCCCATC 960

ATTCAAAAAT TAGAGCAAGC CACCAAAGAG CGCCAAGCAT GGCTTGCTAA AACTAAAGAT 1020

AAAGAAGACG CGCAAGACGC TTTCTTTTAT AATTTTTTAG GGTATTCCTT AATAGATTAT 1080

GACATGGATG TTAAAAGGGG CATGGATCTT GTGAGGAAAG CCTTAGCGTT AGATTCTAAC 1140

TCAGTGCTTT ATTTGGATTC TTTAGCATGG GGTTATTACA AATTAGGGAA TTGTTTGGAG 1200

GCTAAAAAAA TCTTTTCTAG CATCGCTAAA GAGCTTATCC AAAACGAACC CGAATTGAAA 1260

GAACACAATA AAATCATTCA AGAATGCAAG AAATAG 1296

(2) INFORMATION FOR SEQ ID NO: 443:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1245 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE

(A) ORGANISM Helicobacter pylori

(ix) FEATURE

(A) NAME/KEY mιsc_feature

(B) LOCATION 1 1245

(xi) SEQUENCE DESCRIPTION SEQ ID NO 443

TTGATTCAAA AGAACAAGAG CTTATCAATC TTTTTAATCT CAAATTCGGT CGTTTTTCTT 60

GGGAAAATTA TCTTGCATAA AGTTTTTATC ATGGAAGCTT TGGAGTGTTT GAAAAGAATA 120

GAAAAAGAAA GCATCCAAAC AATCTATATA GACCCCCCTT ATAACACCAA GAGTTCTAAC 180

TTTGAATATG AAGACGCTCA TGCTGACTAT GAAAAATGGA TTGAAGAACA TTTGATTTTA 240

GCAAAAGCTG TGTTAAAACA AAGTGGTTGT ATTTTTATTT CTATGGACGA TAATAAAATG 300

GCTGAAGTTA AAATCATTGC CAATGAAATT TTTGGAACGC GCAATTTTTT AGGCACTTTT 360

ATCACCAAAC AAGCCACAAG ATCTAACGCT AAACACATCA ATATTACTCA TGAATATGTT 420

TTAAGCTACG CTAAAAATAA AGCGTTCGCT CCTGGTTTTA AAATCTTACG AACGCTTTTG 480

CCCATTTATG CTAAAGCATT AAAAGATTTA ATGCGAACGA TTAAGAATGT TTTTAAACAA 540

AAAGGACAAG CTCAAGCCCA ACTTATTTTA AAAGAACAAA TCAAAGAGTT ATCCCAAAAA 600

GAACATTTTA ATTTTTTAAA AAATTATAAT TTAGTGGATG AAAAAGGTGA GATCTATTTC 660

GCTAAAGATT TATCCACGCC TTCAAACCCG CGCAGTGTAG CGATACAAGA AATCAATCTT 720

TTTTTAGAAC CCTTAAAAAG CAGAGGGTGG AGCAGCGATG AAAAGCTTAA GGAGTTATAT 780

TATCAAAATA GACTTATTTT TAAGAATAAT CGCCCTTATG AAAAATATTA CCTAAAAGAA 840

TCGCAAGATA ATTGTTTGAG CGTGTTAGAT TTTTATAGCC GACAAGGCAC AAAAGATTTA 900

GAAAAATTAG GCTTAAAGGG GCTTTTTAAA ACGCCAAAAC CTGTAGCATT GATTAAATAT 960

TTATTATTAT GCTCCACCCC TAAAGATTCT ATTATTTTAG ATTTTTTTGC AGGCAGCGGG 1020

ACAACAGCGC AAGCGGTTAT AGAAGTTAAT AAGGATTATT ATTTGAATTG GTCTTTTTAT 1080

TTGTGCCAAA AAGAAGAAAA AATTAAAAAT AACCCGCAAG CTGTTAGCAT TTTAAAAAAC 1140

AAGGGGTATA AAAACACGAT TTCAGACATC ATGCTGTTGC GTTTAGAAAA GATCATCAAA 1200

AGAAGTGAAT ACGAAATTTT AAAAACAAAA TCTATTTTAT TTTAA 1245

(2) INFORMATION FOR SEQ ID NO 444

(l) SEQUENCE CHARACTERISTICS

(A) LENGTH 501 base pairs

(B) TYPE nucleic acid

(C) STRANDEDNESS double

(D) TOPOLOGY circular

(ii) MOLECULE TYPE DNA (genomic)

(ill) HYPOTHETICAL NO

(iv) ANTI -SENSE NO

(vi) ORIGINAL SOURCE

(A) ORGANISM Helicobacter pylori

(ix) FEATURE

(A) NAME/KEY mιsc_feature

(B) LOCATION 1 501

(xi ) SEQUENCE DESCRIPTION SEQ ID NO 444

TTGGAGATTG ATAAAACAGA ATGCTCTACT CTTTTAGCAA GCATTCAAAA ACAACAGCTT 60 GTGATACCCG TTGTGGGGAA TTTTAGCGCA GGCAAAAGCA CGCTATTAAA CCGCTTTTTA 120 GGCAGTAGCG TTTTGCCTAC CGGTATCACG CCAGAGACTT CTTTAGCCAC TGAATTGCAC 180 TATAGCGCTA ATGAACGCAT AGAGGCTTTT TCAAGCAATG ACGAAAAAAC AGAGAGTTTT 240

GAACTGAATG AGCAAAGTTT TGAGGCGATT AAAGAGAATG CGGCGAAGTA TTCCTACCTT 300

AAGGTTTATT TGAATAATGA AGCCTTAAAA GATAGTGCGC CTTTAGTGTT TGTGGATATG 360

CCCGGGTTTG ATAGCCCCAT TTCAAGCCAC ACCCATGCCA TTTTGGAATA TTTGGAAAGG 420

GGCGTGCATT TTGTCATTCT CACAAGCGTA GAAGAGGGTA ACCTCACTAA ACGCATGGTT 480

AGGGAGTTAA AAACCTTTTA G 501

(2) INFORMATION FOR SEQ ID NO: 445:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 756 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_£eature

(B) LOCATION 1...756

(xi) SEQUENCE DESCRIPTION: SEQ ID NO : 445:

ATGAAACTCC CGGTCGTTGA GAGCTTTTTT TCCTTACAGG GTGAAGGAAA AAGGATAGGC 60

AAGCCCAGTC TTTTTTTGCG CTTAGGGGGG TGTAACCTTT CATGCAAGGG CTTTAATTGT 120

AAAACCTTAT TCAATGATGA AATCCTAACA GGTTGCGATA GTTTGTATGC GGTGCATCCT 180

AAATTCAAAA CATCTTGGGA TTATTACAAT GAGCCTAAGC CCTTGATTGA ACGATTAGTT 240

AATTTAGCCC CTAATTATAA GGATTTTGAT TTCATTCTTA CAGGCGGGGA GCCAAGCTTG 300

TATTTTAATA ACCCTATTTT ATTGAGCGTT TTAGAGCATT TTTACCATAA AAAAATCCCT 360

TTATTTGTAG AGAGTAATGG CTCTATTTTT TTTGAATTTA GCCCTATTTT AAAAGAATTG 420

CATTTCACCC TAAGCGTCAA ACTCTCTTTT TCTTTGGAGC AAGAAAGCAA GCGGATCAAC 480

CTTAAAGCCT TACAAAATAT CTTAAATAAC GCTAAAAGCG TGCATTTTAA ATTCGTATTG 540

GAGAGTCAAA ACGCCGCTCA TTCTATCGCA GAAATTCAAA GCCTTTTGAA ACAGCTCTCC 600

TTAAAAAATA ATGAAATCTT TTTAATGCCC CTAGGCACAA CTAACAACGA GCTAGACAAA 660

AATCTAAAAA CCCTAGCCCC CCTAGCCATA GAGCATGGTT TTAGGCTGAG CGATAGGCTT 720

CATATCCGCT TGTGGGACAA TAAGAAAGGG TTTTAA 756

(2) INFORMATION FOR SEQ ID NO: 446:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1146 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE.

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE

(A) NAME/KEY: mιsc_£eature

(B) LOCATION 1...1146

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 446:

ATGAATTTAA ACTTTATGCC CCTATTGCAT GCTTATAACC ATGTAAGCAT TGATTTTCAT 60

TTCAATTCTA GCGCTAGGGA TTTTTGCGTG CATGAAGTGC CTTTGTATGA ATTTAGCAAC 120

ACGGGCGAAC ATGCCGTTAT TCAAGTGAGA AAAAGCGGTT TAAGCACTTT AGAAATGCTT 180

CAAATTTTTT CTCAAATTTT AGGGGTAAAA ATCGCTGAAT TGGGTTATGC GGGCTTGAAA 240

GATAAAAACG CGCTGACGAC TCAATTCATC TCACTCCCTA AAAAATACGC CCCTTTATTA 300

GAAAAAAATA CGAGCAACTT TCAAGAAAGA AACCTTAAAA TCCTGTCTTT GAATTACCAT 360

CACAATAAAA TCAAATTAGG GCATTTAAAG GGGAATCGCT TTTTTATGCG TTTCAAAAAA 420

ATGACCCCCC TAAACGCTCA AAAAACGGAG CAAGTTTTAG AACAAATCGC GCAGTTTGGC 480

ATGCCTAATT ATTTTGGCTC GCAACGCTTC GGGAAGTTCA ATGACAACCA TAAAGAGGGG 540

TTAAAAATCT TGCAAAATGA AACGAAATTC GCCCACCAAA AATTAAACGC TTTTTTAATT 600

TCAAGCTATC AAAGTTATTT GTTTAATTCG CTTTTAAGCA AGCGATTAGA AATCAGTAAA 660

ATCATTAGCG CTTTTAGCGT CAAAGAAAGT TTAGAATTTT TTAAACAAAA AAATTTAAGC 720

GTCCATTCAA ACGCCCTAAA AGCCCTTAAA AACCAAGCCC ACCCCTTTAA AATCTTAGAA 780

GGCGATGTGA TGCGCCATTA CCCTTATGGG AAGTTTTTTG ACGCTTTGGA ATTAGAAAAA 840

GAGAGCGAAA GGTTTTTGAA CAAAGAAGCT GTGCCTACGG GGTTACTGGA CGGTAAAAAA 900

GCTCTTTATG CAAAAAATTT GAGTTTAGAA ATTGAAAAAG GATTCCAGCA TAACCTTTTA 960

AGTGGCCATG CTAAAACGCT AGGATCCAGG CGGTTTTTTT GGGTGTTTGT GGAAAATATA 1020

ACTTCTCAAT ACATCAAAGA AAAAGCGCAA TTTGAATTGG AATTTTACTT GCCTAAAGGG 1080

AGTTATGCGA GCGCGCTGCT CAAAGAAATC AAGCATGAGA AAGGAGAAAA TAATGACGAA 1140

TTTTGA 1146

(2) INFORMATION FOR SEQ ID NO: 447:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2094 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL : NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...2094

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:447:

TTGCAAAACT TTGTTTTTAA TAAAAAATGG CTCATCTATT CTAGCCTACT CCCCTTATTT 60 TTTCTTAACC CTTTAATGGC AGAAGACGAT GGGTTTTTTA TGGGGGTGAG TTATCAAACT 120 TCTTTGGCCG TTCAAAGGGT GGATAACTCA GGGCTTAACG CCAGTCAAGA CGCATCCACT 180 TATATCCGCC AAAACGCTAT CGCTCTAGAA TCTGCGGCGG TGCCTTTAGC CTATTATTTA 240

GAAGCGATGG GCCAACAAAC GAGAGTCTTA ATGCAAATGC TCTGCCCTGA TCCTTCTAAA 300

AGATGTTTGC TCTATGCAGG GGGCTATCAA AACGGACAAA ATAATAACGG CGATACAGGC 360

AACAACCCCC CAAGAGGCAA TGTCAATGCC ACCTTTGATA TGCAATCTCT AGTCAATAAT 420

TTAAACAAGC TCACCCAACT CATCGGCGAG ACTTTAATCC GTAACCCTGA AAATCTTCCT 480

AACTCCAAAG TCTTTAACGT CAAATTTGGC AATCAAAGCA CTGTTATTGC ATTGCCTGAG 540

GGTCTAGCCA ATACCATGGA CGCTTTAAAC AATGACATCA CCAACGCTTT AACCACGCTC 600

TGGTATAACC AAACCTTAAC GAATAAATCT TTTAGCACCC CTAGTAACAC TTCTGTGAAT 660

TTTAGCCCCC AAGTCTTGCA ACACCTTTTA CAAGACGGCT TAGCCACAGC AAATAATAAT 720

CAAACCATTT GCAGCACTCA AAACCAATGC ACCGCCACTA ATGAAGCTAA ATCTATCGCT 780

CAAAACGCCC AAAACATCTT CCAGGCTTTA ATGCAAGCAG GGATTTTAGG GGGCTTAGCC 840

AATGAAAAGC AATTTGGCTT CACTTACAAC AAAGCCCCCA ATGGCAGCGA TTCCCAACAA 900

GGCTATCAAA GCTTTAGCGG CCCGGGTTAT TACACCAAAA ACGACAACAC CACGCAAGCG 960

CCCTTAAAAG CATTACCCGC TGGAGCGACA ATTGGATCAG GCAATGGCCA ATACACCTAC 1020

CACCCCAGCT CGGCAGTCTA TTATTTAGCC GA AGCATCA TCGCTAATGG CATCACCGCT 1080

TCTATGATTT TTTCAGGCAT GCAAAATTTC GCCAATAAAG CCGCTAAACT GATAGGCACT 1140

TCAAGCTATA ACCAGATGCA AGATGTGATC AATTACGGGG AAAGCTTGCT TAGTAACACC 1200

GTAGCGTATG GGGATTTCAT CACCAATTGG GTCGCCCCCT ATTTGGATTT AAACAATAAA 1260

GGTTTGAATT TCTTGCCTAA TTATGGGGGG CAATTGAATG GCGCTAATAA TCAAACCCCA 1320

CAATTAACCC CACAACAAGC CCAACAAGAA CAAAAAGTGA TCATGAACCA ATTAGAGCAA 1380

GCCACAAACG CCCCCACCCC CGCGCAAATA AACAGGATTT TAGCCAACCC CTATTCCCCC 1440

ACGGCAAAAA CTTTAATGGC TTATGGGCTC TATCGCTCTA AAGCAGTGAT TGGCGGAGTG 1500

ATTGATGAAA TGCAAACTAA AGTGAATCAA GTCTATCAAA TGGGCTTTGC TAGGAATTTT 1560

TTGGAGCATA ACTCTAATTC TAATAACATG AACGGCTTTG GCGTGAAAAT GGGCTATAAG 1620

CAATTTTTCG GCAAAAAGCG CATGTTTGGG CTTAGGTATT ATGGTTTTTA TGATTTTGGT 1680

TACGCTCAAT TTGGCACAGA ATCTTCTTTA GTGAAAGCCA CCCTCTCTAG CTATGGAGCG 1740

GGCACAGACT TTCTTTATAA TGTTTTTACC CGAAAAAGAG GGACTGAAGC GATAGATATA 1800

GGTTTTTTTG CCGGTATCCA ACTTGCAGGG CAAACCTGGA AAACGAATTT TTTAGATCAA 1860

GTGGATGGCA ACCATCTTAA ACCTAAGGAC ACTTCTTTCC AATTCCTTTT TGATTTGGGC 1920

ATAAGGACCA ATTTTTCCAA AATCGCTCAT CAAAAAAGAT CTCGTTTTTC TCAAGGGATA 1980

GAATTTGGCC TTAAAATACC GGTGCTTTAT CACACCTACT ACCAATCAGA AGGCGTTACA 2040

GCGAAGTATA GAAGAGCCTT TAGTTTTTAT GTGGGCTACA ACATAGGCTT TTGA 2094

(2) INFORMATION FOR SEQ ID NO: 448:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2094 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...2094

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 448:

TTGCAAAACT TTGTTTTTAA TAAAAAATGG CTCATCTATT CTAGCCTACT CCCCTTATTT 60 TTTCTTAACC CTTTAATGGC AGAAGACGAT GGGTTTTTTA TGGGGGTGAG TTATCAAACT 120

TCTTTGGCCG TTCAAAGGGT GGATAACTCA GGGCTTAACG CCAGTCAAGA CGCATCCACT 180

TATATCCGCC AAAACGCTAT CGCTCTAGAA TCTGCGGCGG TGCCTTTAGC CTATTATTTA 240

GAAGCGATGG GCCAACAAAC GAGAGTCTTA ATGCAAATGC TCTGCCCTGA TCCTTCTAAA 300

AGATGTTTGC TCTATGCAGG GGGCTATCAA AACGGACAAA ATAATAACGG CGATACAGGC 360

AACAACCCCC CAAGAGGCAA TGTCAATGCC ACCTTTGATA TGCAATCTCT AGTCAATAAT 420

TTAAACAAGC TCACCCAACT CATCGGCGAG ACTTTAATCC GTAACCCTGA AAATCTTCCT 480

AACTCCAAAG TCTTTAACGT CAAATTTGGC AATCAAAGCA CTGTTATTGC ATTGCCTGAG 540

GGTCTAGCCA ATACCATGGA CGCTTTAAAC AATGACATCA CCAACGCTTT AACCACGCTC 600

TGGTATAACC AAACCTTAAC GAATAAATCT TTTAGCACCC CTAGTAACAC TTCTGTGAAT 660

TTTAGCCCCC AAGTCTTGCA ACACCTTTTA CAAGACGGCT TAGCCACAGC AAATAATAAT 720

CAAACCATTT GCAGCACTCA AAACCAATGC ACCGCCACTA ATGAAGCTAA ATCTATCGCT 780

CAAAACGCCC AAAACATCTT CCAGGCTTTA ATGCAAGCAG GGATTTTAGG GGGCTTAGCC 840

AATGAAAAGC AATTTGGCTT CACTTACAAC AAAGCCCCCA ATGGCAGCGA TTCCCAACAA 900

GGCTATCAAA GCTTTAGCGG CCCGGGTTAT TACACCAAAA ACGACAACAC CACGCAAGCG 960

CCCTTAAAAG CATTACCCGC TGGAGCGACA ATTGGATCAG GCAATGGCCA ATACACCTAC 1020

CACCCCAGCT CGGCAGTCTA TTATTTAGCC GATAGCATCA TCGCTAATGG CATCACCGCT 1080

TCTATGATTT TTTCAGGCAT GCAAAATTTC GCCAATAAAG CCGCTAAACT GATAGGCACT 1140

TCAAGCTATA ACCAGATGCA AGATGTGATC AATTACGGGG AAAGCTTGCT TAGTAACACC 1200

GTAGCGTATG GGGATTTCAT CACCAATTGG GTCGCCCCCT ATTTGGATTT AAACAATAAA 1260

GGTTTGAATT TCTTGCCTAA TTATGGGGGG CAATTGAATG GCGCTAATAA TCAAACCCCA 1320

CAATTAACCC CACAACAAGC CCAACAAGAA CAAAAAGTGA TCATGAACCA ATTAGAGCAA 1380

GCCACAAACG CCCCCACCCC CGCGCAAATA AACAGGATTT TAGCCAACCC CTATTCCCCC 1440

ACGGCAAAAA CTTTAATGGC TTATGGGCTC TATCGCTCTA AAGCAGTGAT TGGCGGAGTG 1500

ATTGATGAAA TGCAAACTAA AGTGAATCAA GTCTATCAAA TGGGCTTTGC TAGGAATTTT 1560

TTGGAGCATA ACTCTAATTC TAATAACATG AACGGCTTTG GCGTGAAAAT GGGCTATAAG 1620

CAATTTTTCG GCAAAAAGCG CATGTTTGGG CTTAGGTATT ATGGTTTTTA TGATTTTGGT 1680

TACGCTCAAT TTGGCACAGA ATCTTCTTTA GTGAAAGCCA CCCTCTCTAG CTATGGAGCG 1740

GGCACAGACT TTCTTTATAA TGTTTTTACC CGAAAAAGAG GGACTGAAGC GATAGATATA 1800

GGTTTTTTTG CCGGTATCCA ACTTGCAGGG CAAACCTGGA AAACGAATTT TTTAGATCAA 1860

GTGGATGGCA ACCATCTTAA ACCTAAGGAC ACTTCTTTCC AATTCCTTTT TGATTTGGGC 1920

ATAAGGACCA ATTTTTCCAA AATCGCTCAT CAAAAAAGAT CTCGTTTTTC TCAAGGGATA 1980

GAATTTGGCC TTAAAATACC GGTGCTTTAT CACACCTACT ACCAATCAGA AGGCGTTACA 2040

GCGAAGTATA GAAGAGCCTT TAGTTTTTAT GTGGGCTACA ACATAGGCTT TTGA 2094

(2) INFORMATION FOR SEQ ID NO: 449:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3714 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...3714

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 449: ATGATAAAAA AAGCTAAAAA ATTTATACCA CTCTTTTTAA TTGGCTCCCT CTTAGCTGAA 60

GACAATGGCT GGTATATGTC TGTAGGCTAT CAAATCGGTG GCACGCAGCA ATTCATCAAT 120

AACAAACAAC TTTTAGAAAA TCAAAATATC ATCAATAGCA TCACCCAAAG CGCGATCAAT 180

ATTGCAGGGC CTACTACCGG CCTAATCACT TTAAGCTCTC AAAGCGTTAT TGACGCTTTA 240

GGCTATGGCG TGAGTAACAC CGTGGGTAAC CAATTAGAAG GCATTTCTAA TATCCTGAAT 300

CAAATTGGCA AAAGAAAAGA CTTTTATTCT AGCCGTCAAA TCTCTAGCAT TTCCCAGCAA 360

ATCATAGGGC TTAAAGGAAG CTCTGATCCC TTAAAAGCCC ATTCTTCACA AATCACAGCC 420

AAACTCCTTT CCAACACCCA AAGCGCGTTT GATCAGGGCA TCGCTCTAAG CTCTAATATC 480

ATTAGTGCAG TCAATAGCCT AAACCCTAGC AACAACTCCC AAGAAGTCAA AGCCCAGCTC 540

CAAAACACCG CGCAATCCAT GACAGAATTG TTGCAACAAA TTGAACACAG CATCACTAAA 600

ACCACTAGCA CCACTTACGC ACAATCCTTA CTCTCCAATC TGACCGATGC GGTGAATGCA 660

TCTAGCAATA ATACCACTTA TGTGAGCGCT CTTGTTAACG CTTTAAACAC TTTAGGGGTG 720

GGGGTTTTCC CCACCACAAC CTCAACGCAT GTGGTGCTAA ACCCACCGGG ACAAGTCGTA 780

TTCTATCCAA CTAATTCCCT TTTAGGCTCT ACTTCTTCAA ACAGCAATAA CCAACAACAA 840

TACAACAACA CCCTTTTAAT GAACACCTTA CAAGGGGAAT TAAGCACTAA CAATCAAAAT 900

AACCCCAATG GTTGCGCCAA TCAAATCCAG TGTTTAGAGC AATTCATCCA AAATTTAACC 960

CCTTTAGCCG CAACCCCCAC TTCAACTAAC CAGGCCAACC AGCAAGTCCA AGCCATCGCT 1020

CAAAAACTTC AAAGCGTTGC TATCAACGCT TTAGACAACA ATGCGATCAA CAACACCACC 1080

TATAATTTAA ACAACTTGCA CAACGCTTTG AATTTCCAAG CCTATCAAAG CACGATAGAA 1140

CAATACAATA ACGCTTTAAA GCAAATTTCG TGGATTAGTT TTAGCGAGCC TAAAAACTTG 1200

CTCAAAAACA CTTCCAATAA CTACCAAATC GGCACGGTTA CCAACGATCA AGGGCAAAAT 1260

ATCAGCGCCT ATGATTGCAC AAGCGCTACC GGAAGCCTTT CTAGCGATGC TTCTAGTGGG 1320

ATTTCATGCT CAGCCACAAG CTCCACAAAT AACACAAATA GTTTTGACAA TTCTTTAGTC 1380

GCTACCTCCA AAGTCCAAAC CATCAACGGC AAAGAGCAGA TCGGCGTGAA TTCTTTTAAT 1440

CTTGTCTCTC AAGTGTGGAG CGTTTATAAC TCTTTAAAAA CTTCAGAAGA AAATTTGCAA 1500

AAAAACGCCA AAATATTATG CAACAATGGA TCGCAATCTG GGACAAGCCC ATGCAATAGC 1560

TCTTCAGGGG GTTTGAGCAT CAGCGGGAAC GCCCAATTGC AAAATATTTT AAGCCCTACT 1620

AATGGGACTA CCACTAATAC TCAAGCTAAA AGCAACGCTT CCAAACTAAA AGCGATGGTA 1680

ATGGTGAATA ATGAAGAAGA AGCCAAAACG ACCAATTTCA ATCAAAGCAG TGGGCCAACC 1740

ACACAATCTT CTAACAGCAC GGTGATGGGA GCTTTAAACA CCGTATTGCA AAATGTCAGC 1800

AATTTCCAAC AAAGCATTCA AAGCGCTTTT CAAAACCAAG AAAATAATAT CCAAGCTTGG 1860

GCGAACGCAC TTTATAACAC TAGTAACCCT AATGGGAATC AATCGCAAAA TTTAACCACT 1920

AACAATAACC AAGATTTACG CATCCAATTA AGGGCGAATT TTTACCAGCT CATCAATACC 1980

ATTAACCAGC AAGTGCCTAC AGACATGAAC GCTTTAATTA ATCAAAGCCA ACAAACCCAG 2040

CAAACAAGCG GATCAGCAAG CACCACGAAC AACGCATGCG CGAGCGGAAT GGGGAGTAGT 2100

GGCAACTGGT GCTACCAGCA GTGGTCCGAT TCTAAGGCTT ATTACAGCGG GTTGCAAAGC 2160

GCTTTAGGGT ATCAAACACA AGCGACAACT CAAAATGGGA GCAGTGGTGG GAGCAATATC 2220

ACCTACAATG TCCAACAAAT CACGCTCACT AGCGGTGGTT TGCTCAATCA AATTATCACA 2280

AACCTTAAGA GCGTTAATGG GGGCAGTAAT GGGGGAAGCA GTGGGAATGG CACTAGTCAA 2340

ATCAACACAG CCTACCAAAT GCTCACAGAC GCTAGCGATG GGAAATTAGG GACTTATAAT 2400

AGTAGCAATA GTAGCAATAG TAGCAATAGT GGCAATAATA ACGGCTATAC GCCATGCAAT 2460

AGCACCAACG GGAGCAATGG GACGAGTGGG AGCAATTGTT ATGAACCCAA CAAACAACAA 2520

AACGCCACCA CCGCAACCAC CACGACCGAC AGCAATTTAC AAAAAGTCTA TAATGACGCC 2580

CAAAAAATAG CCAATATTAT CGCCAGCTCT GGGAACAATA AAGGCGTTGA AAACGGCTTA 2640

AAACAATTCT TTGAAGCGTT AAAAAGTAAT AGCAGCAGTC TTAGTAATTT ATGTGGTAAT 2700

GGTAGTAGCG GTAGTAGCTC TACTTGCTCC GGTGGGCTTA TCAACCTTTT AGGGGCAATC 2760

CCCACAAACG GAGTGAGCGA TACGAATAAT TTAATTAATC TGCTCACTGA ATTCATTAAA 2820

ACCGCCGGGT TTATCCAAAA TAATGATAGT AATGTATCTA CTAGTCTTAC AAGCGCTTTT 2880

CAAGCCATTA CGAGCGCTAT TTCTCAAGGG TTTCAAGCCT TGCAAAACGA TATTAGCCCT 2940

AATGCGATTT TGACCTTGCT CCAAGAAATC ACTTCTAACA CCACCACCAT TCAGTCATTC 3000

TCGCAAACCT TACGGCAGCT TTTAGGGGAT AAAACCTTCT TTATGGTGCA ACAAAAGCTC 3060

ATTGATGCGA TGATTAACGC CAGAAATCAG GTTCAAAACG CGCAAAATCA AGCCAATAAC 3120

TACGGCTCTC AACCCGTTTT AAGCCAGTAT GCGGCCGGTA AAAGCACCCA ACACGGCATG 3180

AGCAATGGCT TAGGGGTTGG CATAGGCTAT AAATACTTCT TTGGTAAGGC TAGGAAATTA 3240

GGCCTTAGGC ATTATTTTTT CTTTGATTAC GGCTTTAGTG AAATAGGCCT AGCCAATCAA 3300

AGCGTGAAAG CGAATATCTT TGCTTATGGG GTAGGCACGG ATTTTTTATG GAATCTATTC 3360 AGGAGGACTT ACAACACTAA AGCGTTGAAT TTTGGGCTAT TTGCCGGGGT CCAACTGGGC 3420

GGTGCAACTT GGCTTAGTTC CTTAAGGCAA CAAATCATTG ACAACTGGGG GAACGCTAAT 3480

GACATCCATT CAACGAATTT TCAAGTGGCG CTGAATTTTG GGGTGCGCAC CAATTTCGCG 3540

GAGTTTAAGC GTTTTGCTAA GAAATTCCAC AATCAAGGGG TCATCAGCCA AAAGAGCGTG 3600

GAATTTGGGA TCAAGGTGCC TCTCATCAAT CAAGCGTATT TGAATAGTGC TGGGGCTGAT 3660

GTGAGCTACA GGAGGCTTTA TACTTTCTAT ATCAATTACA TCATGGGGTT TTAA 3714

(2) INFORMATION FOR SEQ ID NO: 450:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 516 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...516

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:450:

ATGGAAAAAT TACCTAAAAA ACGAGTTTCT AAAACCAAAT CACAAAAACT TATCCATAGC 60

CTAACCACCC AAAAAAACAG AGCCTTTCTC CAAAAAACCA GCGCCAATGA AATGCTTTTA 120

GAGTTAGAAA AAGGGGCGTT TAAAAAAAAT GAAGCCTATT TTATTTCTGA TGAAGAAGAT 180

AAAAATTACG TTTTAGTGCC GGACAATGTG ATCTCTCTTT TGGCAGAAAA CGCCAGAAAG 240

GCTTTTGAAG CCAGGCTTAG GGCGGAATTA GAAAGGGATA TTATCACCCA AGCGCCGATT 300

GATTTTGAAG ACGTGCGCGA AGTTTCTTTG CAATTGTTAG AAAATTTACG CCAAAAAGAC 360

GGGAATTTGC CCAATATCAA CACCTTAAAT TTTGTCAAAC AAATCAAAAA AGAACACCCT 420

AATTTATTCT TTAATTTTGA CAACATGTTC AAACAACCCC CTTTTAATGA GAATAATTTT 480

GAAAATTTTG ACAATAGCGA TGAGGAAAAT TTTTAA 516

(2) INFORMATION FOR SEQ ID NO: 451:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1308 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori ( ix ) FEATURE :

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1308

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 451:

ATGAAAAAAA TTTTAATCAC TTTAATCACT TTATTATTAG GAGTTTTTAT GGGGTTACAA 60

GCGAGTGCTT TGACACACCA AGAAATCAAT CAAGCTAAAG TCCCTGTGAT TTATGAAGAA 120

AACCATTTGT TACCCATGGG GTTTATCCAT TTAGCCTTTA GAGGGGGTGG GAGCTTGAGC 180

GATAAAAACC AGTTGGGTTT GGCGAAATTG TTCGCGCAAG TTTTAAACGA AGGCACTAAA 240

GAGCTTGGCG CGGTGGGGTT TGCGCAACTT TTAGAGCAAA AAGCGATCAG TTTGAATGTG 300

GATACCAGCG CAGAAGATTT GCAAATCACT TTAGAATTTT TAAAAGAATA CGAAGATGAA 360

GCCATAATGC GCTTAAAAGA GCTTTTAAAA TCCCCTAATT TCACGCAAAA CGCTTTAGAA 420

AAAGTCAAAA CCAGAATGTT AGCCCAACTT TTACAAAAAG AAAGCGACTT TGATTATTTG 480

GCTAAACTGA CTTTAAAACA AGAGCTTTTT GCTAACACCC CTTTAGCTAA TGCGGCCTTA 540

GGCACTAAAG AGAGTCTTCA AAAAATCAAG CTAGACGATT TGAAACAGCA ATTTGCTAAG 600

GTTTTTGAAC TCAATAAACT CGTGGTGGTG CTTGGGGGCG ATTTGAAAGT CAATCAAACG 660

CTCAATCGTT TAAATAACGC CCTCAATTTC TTGCCGCAAG GTAAAGCCTA TGAAGAGCCT 720

TATTTTGAAG CGAGCGATAA AAAAAGTGAA AAAGTCCTCT ATAAAGACAC TGAGCAGGCT 780

TTCGTGTATT TTGGCGTGCC CTTTAAAATC AAGGATCTAA AACAGGATTT AGCGAAATCT 840

AAAGTCATGA TGTTTGTGCT TGGGGGGGGG TTTGGCTCTC GTTTGATGGA AAAAATCAGG 900

GTTCAAGAGG GCTTGGCTTA TAGCGTGTAT ATCCGCTCCA ACTTTTCTAA AGTGGCGCAT 960

TTTGCGAGCG GGTATTTGCA AACCAAGCTC AGCACTCAAG CTAAAAGCGT TGCCTTAGTT 1020

AAAAAAATAA TTAAAGAATT TATAGAAAAA GGCATGACGC AACAAGAATT AGACGACGCT 1080

AAAAAGTTTT TACTAGGCTC TGAGCCTTTA AGGAATGAAA CGATCTCAAG CCGCTTGAAC 1140

ACCACTTACA ATTATTTTTA TTTGGGTTTG CCTTTAGATT TCAACCAAAC GCTACTCAAT 1200

CAAATCCAAA AAATGAGTTT GAAAGAGATC AATGATTTCA TTAAAGAGCA TACCGAAATC 1260

AACGACTTGA CCTTTGCTAT TGTGAGCAAT AAAAAGAAGG ACAAATAA 1308

(2) INFORMATION FOR SEQ ID NO: 452:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1845 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1845

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 452:

TTGGCTTCTC CAAAAGAAAC CCCAAAAGAG GCTCAAAAAA ATGAAGCTCA AAACGAAACC 60

TCTCAATCCA ATCAAACGCC TAAAGAAATG AAAGTCAAGT CCATTTCTTA TGTCGGGCTT 120

TCTTACATGT CTGACATGCT CGCTAATGAA ATTGCAAAGA TTCGCGTGGG CGATATGGTG 180

GATTCTAAAA AAATAGACAC CGCTGTTTTA GCTTTGTTCA ACCAAGGGTA TTTTAAAGAC 240

GTTTATGCCA CTTTTGAAAA CGGCATTTTA GAGTTTCATT TTGATGAAAA AGCCAGGATT 300 GCCGGGGTAG AAATCAAGGG TTATGGGACT GAAAAGGAAA AAGACGGCTT AAAATCCCAA 360

ATGGGGATCA AAAAGGGCGA CACCTTTGAT GAGCAAAAAT TAGAGCATGC TAAAACGGCT 420

TTAAAAACGG CTTTAGAGGG GCAGGGCTAT TATGGGAGCG TGGTGGAGGT GCGCACAGAA 480

AAGGTCAGTG AGGGAGCGTT ATTGATCGTG TTTGATGTGA ATAGGGGGGA CAGTATTTAT 540

ATCAAACAAT CCATTTATGA GGGAAGCGAT AAATTAAAAC GCCGTGTGAT TGAATCTTTG 600

AGCGCGAACA AGCAGCGCGA TTTCATGGGC TGGATGTGGG GCTTGAATGA CGGGAAATTG 660

CGCTTAGATC AATTAGAATA CGATTCTTTG CGTATCCAAG ATGTGTATAT GCGTAGGGGT 720

TACTTAGACG CTCATATTTC TTCGCCTTTT TTGAAAACGG ATTTTTCCAC CCATGACGCT 780

AAGCTCCATT ATAAGGTCAA AGAGGGGATC CAATACAGGA TTTCAGATAT TTTAATAGAG 840

ATTGACAACC CGGTAGTCCC CTTAAAAACC TTAGAAAAAG CGCTTAAAGT TAAAAGGAAA 900

GATGTCTTTA ATATTGAGCA TTTAAGAGCG GATGCGCAAA TTTTAAAAAC CGAAATCGCC 960

GATAAGGGCT ATGCGTTTGC GGTGGTGAAG CCAGACTTGG ATAAAGACGA AAAAAACGGG 1020

CTTGTGAAAG TCATTTATCG TATTGAAGTG GGCGATATGG TGCATATCAA TGATGTCATC 1080

ATTTCAGGGA ACCAGCGCAC GAGCGATAGG ATCATTAGGA GGGAATTGTT ACTAGGGCCT 1140

AAAGATAAAT ACAACTTGAC CAAACTGAGA AATTCCGAAA ATTCTTTGAG GCGTTTAGGG 1200

TTTTTCTCTA AAGTCAAGAT TGAAGAAAAA AGGGTCAATA GCTCATTGAT GGATTTGTTA 1260

GTGAGCGTAG AAGAGGGGCG CACCGGGCAG TTGCAATTCG GGTTGGGCTA TGGCTCTTAT 1320

GGAGGGCTCA TGCTTAATGG GAGCGTGAGC GAAAGGAATC TTTTTGGCAC AGGGCAAAGC 1380

ATGAGCTTGT ATGCTAACAT TGCCACAGGG GGGGGTAGAT CTTATCCGGG CATGCCAAAA 1440

GGGGCGGGGC GTATGTTTGC CGGGAATTTG AGCTTGACTA ATCCAAGGAT TTTTGACAGC 1500

TGGTATAGCT CTACGATCAA TCTTTATGCG GATTACAGGA TAAGCTACCA ATACATCCAA 1560

CAAGGCGGGG GCTTTGGGGT GAATGTCGGG CGCATGCTGG GTAATAGAAC CCATGTGAGC 1620

TTAGGGTATA ACTTGAATGT TACCAAACTC CTTGGTTTCA GCAGCCCCTT ATACAACCGC 1680

TACTATTCCT CTGTTAATGA AGTGGCCTCT CCAAGGCAAT GTTCCACACC CGCATCGGTG 1740

ATTATCAACC GCTTATCAGG CGGTAGAACT CCATTGGTTC CTGAAAGCTG TTCTAGTCCT 1800

GGAGCGATCA CCATCTTCAC CAGAAATAAA AGGTATTTGG GATAG 1845

(2) INFORMATION FOR SEQ ID NO : 453:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1131 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1131

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 453:

TTGTGTGAGG GCCCTAACGT GATGAGCGGT TGGAAACCCC ACATCAAGCA TGGCGTTTAT 60

AGAAACTGGA ATAACTGGCG CAACAATTAC ACAGCGGTCT ATTTGAGCGA TCGCATTGAA 120

GCTTGGGACG GGCGCTTTTT CATCGTGCCT GGTTTGCGCT ACGCTTTTGT GCAATACAAC 180

AACGAAAATG CGTCTAACTG GATGCAAATC CCTGAGAAGG ATTTAAGAAA AATCAAGCAC 240

ATGAACAATT GGATGCCCTC AACCAACATT GGCTTTATCC CTGTGCAAGG CGATCACAAT 300

GTGCTTACCT ACTTCAACTA CCAACGCTCT TTCGTCCCGC CTCAATTAGA CGTTTTGAGC 360

TATGGAGGAG CGGAGTATTT TACCCAACAC TTTGACACGG TGGAAGCAGG AGCGCGCTAC 420 ACCTATAAAG ATAAATTCAG CTTCAATGCG GACTACTTTA GGATTTGGGC GCGCGATTTT 480

GCCACCGGGC AGTATTCAGT CTATACGAGC GGGCCCATGA AAGGTAATGT GCGCCCCATT 540

AATGGCTATT CTCAAGGCGT GGAGCTGGAA TTGTATTACA GGCCCATTAG AGGGTTGCAA 600

TTCCATGCCG CTTTCAACTA CATTGACACT CGTGTAACTA GCCATGGCCC TTTAACCGAC 660

TTGAACGGGG ATGTGCTAAA AGGGACTAGC TATAACAAGC ATTTCCCTTT TGTAAGCCCT 720

TTCCAATTCA TTTTTGACGC TCGCTACAAT TGGCGTAAAA CCACCATTGG TATTTCTAGC 780

TATTTTTATA GCCGTGCTTA TAGCGGGATT AGCAACAGCG CAGCAGGAGG CTATTATGGG 840

ATGCAATACT ATAGTGGGGG GAACAACTAT GAAAGCGTTC TTAATAGCGG TTATCAATGC 900

GAAGCTTGGT GTATGACCCA ACATGAAGGG CTCTTGCCTT GGTATTGGGT GTGGAATATC 960

CAAGTGAGCC AAATTTTCTG GGAAAACGGA AGACACAGAG TTACAGGAAG CTTACAAATC 1020

AATAACATCT TCAACATGAA GTATTATTTT ACAGGGATTG GCTCTAGCCC TGCAGGCTTG 1080

CAACCTGCGC CTGGAAGATC GGTTACAGCG TATTTGAACT ACACTTTCTA A 1131

(2) INFORMATION FOR SEQ ID NO: 454:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1866 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1866

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 454:

TTGCATGCTG AAGACAACGG CTTTTTTGTG AGCGCGGGCT ATCAAATCGG CGAAGCGGTG 60

CAAATGGTCA AAAACACCGG CGAATTGAAA AACTTGAACG ACAAATACGA GCAGTTAAGC 120

CAATCTTTAG CCCAACTGGC TTCGTTAAAA AAAAGCATTC AAACGGCGAA CAACATTCAG 180

GCTGTCAACA ATGCTTTAAG CGATTTAAAA AGCTTTGCGA GTAACAACCA CACAAACAAA 240

GAAACATCGC CCATCTACAA CACCGCGCAA GCTGTTATCA CTTCAGTATT GGCTTTTTGG 300

AGTCTTTATG CAGGGAACGC TCTCAGTTTT CATGTGACCG GTTTGAATGA TGGATCTAAT 360

TCTCCTTTAG GAAGAATCCA TAGAGATGGG AACTGCACAG GATTACAACA ATGTTTTATG 420

AGCAAAGAAA CTTATGATAA AATGAAGACA CTTGCCGAAA ACCTCCAAAA AGCTCAAGGC 480

AATCTCTGTG CCTTATCAGA ATGCTCTAGC AATCAATCAA ATGGAGGCAA AACTTCCATG 540

ACTACAGCTC TTCAAACCGC GCAACAGCTC ATGGACTTAA TCGAACAGAC CAAGGTTTCT 600

ATGGTGTGGA AAAATATCGT CATCGCAGGT GTTACAAACA AACCCAATGG TGCTGGCGCT 660

ATCACATCCA CTGGTCATGT AACCGACTAT GCGGTGTTTA ACAACATCAA GGCGATGCTA 720

CCTATCTTGC AACAAGCGCT TACGCTTTCT CAAAGTAACC ACACCCTATC CACTCAGTTG 780

CAAGCTCGAG CTATGGGATC TCAAACAAAT CGTGAATTCG CTAAAGACAT CTACGCTTTA 840

GCTCAAAACC AAAAGCAAAT CCTTTCTAAC GCTTCAAGTA TCTTCAATCT CTTTAATTCC 900

ATTCCTAAAG ACCAACTTAA GTATTTGGAG AACGCTTACT TGAAAGTGCC ACATTTGGGT 960

AAAACCCCTA CTAACCCTTA CAGACAGAAT GTGAATTTGA ATAAAGAAAT TAATGCGGTT 1020

CAAGACAATG TAGCTAATTA TGGTAATCGT TTGGATTCGG CTTTAAGCGT GGCTAAAGAT 1080

GTTTATAACC TAAAATCCAA TCAAACAGAG ATCGTAACCA CTTATAACGA TGCTAAGAAT 1140

TTGAGCGAAG AGATTTCTAA ACTTCCCTAT AACCAAGTCA ATGTAACAAA CATCGTTATG 1200

TCGCCTAAAG ATTCTACAGC GGGCCAATAC CAAATCAACC CAGAGCAGCA ATCCAATCTT 1260 AACCAAGCTT TAGCGGCGAT GAGCAATAAC CCCTTTAAAA AAGTGGGCAT GATCAGCTCT 1320

CAAAACAATA ACGGCGCTTT GAACGGGCTT GGCGTGCAAG TGGGTTATAA ACAATTCTTT 1380

GGCGAAAGCA AAAGATGGGG GTTAAGGTAT TATGGTTTCT TTGATTACAA CCACGGCTAT 1440

ATCAAATCCA GCTTTTTTAA TTCTTCTTCT GATATATGGA CTTATGGCGG TGGGAGCGAT 1500

TTGTTAGTGA ATTTTATCAA CGATAGCATC ACAAGAAAGA ACAACAAGCT TTCTGTGGGT 1560

CTTTTTGGTG GTATCCAACT AGCAGGGACT ACATGGCTTA ATTCTCAATA CATGAATTTA 1620

ACAGCGTTCA ATAACCCTTA CAGCGCGAAA GTCAATGCTT CCAATTTCCA ATTTTTGTTC 1680

AATCTCGGCT TGAGGACGAA TCTCGCTACA GCTAAGAAAA AAGACAGCGA ACGTTCCGCG 1740

CAACATGGCG TTGAACTGGG CATTAAAATC CCTACCATTA ACACCAATTA TTATTCTTTT 1800

CTAGGCACTA AGCTAGAATA CCGAAGGCTT TATAGCGTGT ATCTCAATTA TGTGTTTGCT 1860

TATTAA 1866

(2) INFORMATION FOR SEQ ID NO: 455:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 492 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...492

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 455:

ATGATGCGAG AGATCCTTAC TAACCGCTTT TTCCCAAGCC TTTTTAAAAA AAGGCTTGAT 60

TTTTCTAACA GAGTGGTTTT AGGGCTGGGA TCTAATCTTA AAAACCCTTT AAAAATATTA 120

AAAAGTTGTT TTTTATATTT TAAAAATCAT AGTAAAATCG GGAAAATTTT TTCTTCACCC 180

ATTTATATCA ATCCGCCTTT TGGTTACACT AATCAACCTA ACTTTTATAA CGCTACGATT 240

ATCCTTAAAA CATCTTTAGG TTTGCGCCAT TTTTTTGCTC TAGTGTTTTA TATAGAAAGG 300

CGTTTTGGGC GTGCAAGGAA GCGCGATTTT AAAGATGCTC CAAGAACTTT AGATATTGAT 360

ATTATCGCTT TCAATCAAGT CATTTTGAGG CAGAATGATT TGACTTTACC TCACCCTAAA 420

TGGAGTGAAA GAGACTCGGT GTTAGTGCCT TTAACTTTAC AACAAATCCT TTTTAAAAGA 480

GAAGAGTGGT GA 492

(2) INFORMATION FOR SEQ ID NO: 456:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 858 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_£eature

(B) LOCATION 1...858

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 456:

ATGCAAGATT TTATTAAGAT TTTTATTCAA GAGGTTGTCT CTACTTTAGA AGGGTTAGTG 60

GGTAAGGCTC CAAGCGTAGG ATTAGAAAAA GAAGTTTCTA ACAATGAAGA AGCGAGTTTA 120

ATCAGCACTC CTTATGCAAG GGTTAAGATT AGCGCGATTG AAAAAAATGA AAGTCCTATT 180

GAATTACTGG CTCCGGTAGA TTTAGTTACC GCTTTGAGCG ATTTGATGCT AGGAGGTGAG 240

GGGGCGAGCA AGGAAGAAAT GGATAATGAC GATTTAGACG CTTTTAAAGA AATGGCTTCT 300

AATATTTTTG GTGCGATCGC TACAAGCTTG AAGTCTCAAG AATTGCTCCC TAAACTCAAT 360

TTCACCACCA CGAACGCTGA AATCGCTAAA GAGCTTCCTA AAAAAGAAGA TTACGCTAAG 420

GCGATGGTGT TTTCTTTTAA AATGGAAGCC ATCAAAGAAA GCCAAATCGT TTTATTGATC 480

ACTTCAGCGT TTGAGGGCCA ATTTGAAAAA ACGCATAAAG AAGAAAAAGA AGAAACGACA 540

AAAAGCGCTA CTGAAGAGAC TAAAACCCAC GACGCGTCTT TAGAAAATAT AGAAATCCGC 600

AATATCAGCA TGCTTTTAGA CGTGAAATTG AACGTTAAGG TGCGTATCGG TCAAAAAAAG 660

ATGATTTTAA AAGATGTGGT CTCTATGGAT ATAGGGAGCG TGGTGGAGTT GGATCAATTG 720

GTGAATGACC CTTTAGAAAT CCTCGTAGAT GACAAGGTGA TCGCTAAGGG CGAAGTGGTG 780

ATCGTGGATG GGAATTTTGG CATTCAAATC ACGGATATTG GCACTAAAAA GGAACGATTA 840

GAGCAACTGA AAAATTAA 858

(2) INFORMATION FOR SEQ ID NO: 457:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 513 base pairs

(B) TYPE: nucleic acid

( C ) STRANDEDNESS : doub1e

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...513

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 457:

ATGAAAATTT TAGTGATTCA AGGGCCTAAT TTAAACATGT TAGGACACAG AGACCCAAGA 60

CTTTATGGCA TGGTAACCTT AGACCAAATC CATGAAATCA TGCAAACTTT CGTGAAGCAA 120

GGCAATTTAG ATGTGGAATT AGAGTTTTTT CAAACCAATT TTGAGGGCGA AATCATTGAT 180

AAAATCCAAG AGAGCGTGGG CAGCGATTAT GAGGGGATTA TCATTAACCC TGGAGCGTTT 240

TCGCACACTT CTATTGCGAT TGCGGATGCG ATCATGCTAG CGGGCAAACC TGTCATTGAA 300

GTGCATCTCA CTAACATTCA AGCCAGAGAA GAATTCAGGA AAAATTCTTA CACCGGAGCG 360

GCTTGTGGAG GCGTGATCAT GGGATTTGGC CCGCTTGGCT ACAACATGGC TTTAATGGCG 420 ATGGTCAATA TTTTAGCCGA AATGAAAGCG TTCCAAGAAG CCCAAAAAAA CAACCCTAAT 480 AACCCCAATA ACCCGATCAA CAATCAAAAA TAA 513

(2) INFORMATION FOR SEQ ID NO: 458:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1074 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1074

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 458:

ATGAGAGGAT TAGAAAGAGA ATCGCATTTC ACGCTCAATG AAAACGCGAT GTTTTTTGAG 60

TGCGCTTATA GTTGCGATAA CGCTTTGTTT TTGCAATTAG ACGATCGCTC GTTCTTTATC 120

ACTGATTCTC GTTACACCCA AGAAGCTAAA GAAAGCCTTC AGCCTAAAAA GGGCGTTTTA 180

GTGGAAGTGA TAGAGTCTAG CGATTTAGTC CAAAGCGCGA TTGATTTAAT TACAAAGAGT 240

TCGGTTAAAA AGCTCTTTTT TGACCCCAAT CAAGTGAATT TGCAAACCTA CAAGCGTTTG 300

GATTCAGCGG TTGGGAATAA GGTTGTTTTA GAGGGCGTGC CCAGTTACCA CCGCCAAAAA 360

CGCATCATTA AAAACGAGCA TGAGATCCAA CTCCTCAAAA AATCTCAAGC GTTGAATGTT 420

GAAGCTTTTG AAAATTTTGC CGAGTATGTG AAAAAGATTT TTGATGAAAA AGAGTCATTG 480

AGCGAGCGGT ATTTGCAGCA TAAGGTTAAA GACTTTTTGA CTAAAGAGGG GGTTTATGAT 540

CTGAGTTTTG AGCCTATTTT AGCCTTGAAT GCGAACGCGA GCAAACCCCA TGCCTTGCCT 600

AGTGCGAAGG ATTTTTTAAA AGCGGATCAT AGCATTCTTT TGGATATGGG GATCAAATAC 660

GAACGCTATT GCTCTGATAG GACTCGCACG GCTTTTTTTG ACCCTAAAGA CTTTGTGTTC 720

AAAAGGGAGC AGAGTTTCAA GGATAAAGAG CGTCAAAAGA TTTATGACAT TGTGAAAGAA 780

GCGCAAGAAA AGGCTATTTC AGGCATTAGA GCGGGCATGA CCGGTAAAGA AGCGGACAGC 840

TTGGCTAGGG GAGTGATTAG CGATTATGGT TATGGGCAGT ATTTCACTCA CAGCACCGGG 900

CATGGCATTG ACTTAGACAT TCATGAGCTT CCCTATATTT CATCGCGCAG TGAAACCATT 960

TTAGAAGAGG GCATGGTGTT TTCTGTAGAG CCTGGGATTT ATATCCCTGG GTTTTTTGGG 1020

GTGCGCATTG AGGATTTAGT GGTGATTAAA AATTCTAGGG CCGAGCTTTT ATGA 1074

(2) INFORMATION FOR SEQ ID NO: 459:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1158 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic) (ill) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1158

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 459:

ATGAAAGATA GTTTTCTTTT CACTTCCGAA TCAGTAACCG AAGGGCATCC TGATAAAATG 60

GCCGATCAGA TCAGCGATGC GGTTTTAGAT TACATTATTG AGCGGGATAA AAAAGCCAAA 120

GTCGCATGCG AGACTTTAGT TTCTAATGGT TTTTGCATGA TCACTGGCGA GTTAAAAACT 180

TCTGTTTATG CCCCGATGCA AGAGATCGCA AGAGAAGTGG TTAAAAAAAT TGGCTATACA 240

GACGCTCTTT ATGGCTTTGA TTACAGAAGC GCGGCGGTTT TAAATGGCAT TGGCGAGCAA 300

AGCCCTGATA TTAATCAAGG CGTGGATAGA GAAGATGGCG AGATTGGGGC GGGGGATCAA 360

GGGCTTATGT TTGGTTATGC ATGCAAAGAG ACTGAAACGC TCATGCCTTT ACCCATCCAT 420

TTAGCGCACC AGCTCGCTTT CGCTCTAGCT CAAAAAAGAA AAGACAACAC CTTGCCTTTT 480

TTAAGGCCTG ATGGCAAGTC TCAAGTGAGC GTGCGTTATG AAAACAACAA GCCTGTAAGC 540

GTTGATACGA TTGTCATTTC CACCCAACAT TCCCCAGAAG TTTCACAAAA GCATTTAAAA 600

GAAGCGGTGA TTGAAGAGAT CGTGTATAAG GTTTTACCCA AAGAATATTT GCATGACAAT 660

ATCAAGTTTT TTATAAACCC TACAGGAAAA TTCGTCATCG GTGGGCCTCA AGGCGATGCG 720

GGTTTGACAG GTAGAAAAAT CATCGTGGAT ACTTATGGAG GGTTTTGCCC GCATGGAGGG 780

GGAGCGTTTA GCGGGAAAGA CCCTAGCAAG GTGGATAGGA GCGCGGCTTA TGCGGCCCGC 840

TATGTGGCTA AAAATTTGGT AGCGAGCGGG GTTTGCGATA AAGCGACCGT GCAGCTTGCT 900

TATGCGATTG GGGTGATAGA GCCTGTGTCT ATTTATGTGA ACACGCATAA CACGAGCAAG 960

CATTCAAGCG CGGAGTTGGA AAAATGCGTG AAATCGGTTT TCAAACTCAC GCCAAAAGGC 1020

ATCATTGAAA GCTTGGATTT GTTAAGACCC ATTTATTCGC TCACTTCAGC TTATGGGCAT 1080

TTTGGGCGCG AGTTAGAAGA ATTCACTTGG GAAAAGACTA ACAAGGTTGA AGAGATTAAA 1140

GCGTTCTTTA AGCGTTAA 1158

(2) INFORMATION FOR SEQ ID NO: 460:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 657 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...657

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:460:

GTGTTAGATA GTTTTGAGAT TTTAAAGGCT TTAAAGAGCT TGGATTTATT GAAAAACGCC 60 CCTGCTTGGT GGTGGCCTAA CGCTTTGAAA TTTGAAGCTC TACTAGGAGC GGTTTTAACG 120 CAAAATACTA AATTTGAAGC CGTTTTGAAA TCTTTAGAAA ATCTAAAAAA CGCTTTCATT 180

TTAGAAAATG ATGATGAGAT CAATCTTAAA AAAATCGCTT ATATAGAGTT TTCAAAGCTT 240

GCAGAGTGTG TCCGCCCTAG CGGGTTTTAT AACCAAAAAG CCAAACGACT GATTGATTTG 300

AGCAAGAATA TTTTAAAAGA CTTTCAAAGT TTTGAAAATT TTAAACAAGA AGTAACCAAA 360

GAGTGGCTTT TAGACCAAAA GGGCATTGGC AAAGAAAGCG CGGATGCGAT TTTATGCTAT 420

GTGTGCGCCA AAGAAGTGAT GGTGGTGGAT AAATACAGCT ATCTTTTTTT AAAAAAATTA 480

GGCATAGAGA TAGAAGATTA TGATGAATTG CAGCATTTTT TTGAAAAAGG CGTTCAAGAG 540

AATTTAAATT CCGCCTTAGC GCTTTATGAA AACACCATTT CTTTAGCGCA ACTTTATGCG 600

AGATTCCATG GAAAGATCGT GGAATTTTCC AAACAAAAAT TGGAATTGAA GCTTTGA 657

(2) INFORMATION FOR SEQ ID NO: 461:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 399 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...399

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:461:

ATGAAACAAC TATTTTTGAT TATTGGAGCC CCAGGGAGTG GTAAAACCAC TGACGCAGAG 60

CTTATCGCTA AGAATAACAG CGAAACAATC GCTCATTTTT CTACTGGGGA TTTACTCAGG 120

GCTGAGAGCG CTAAAAAGAC TGAGCGAGGC TTATTGATTG AGAAATTCAC TTCTCAAGGC 180

GAATTAGTGC CTTTAGAAAT TGTGGTAGAA ACGATCCTTT CAGCGATTAA AAGCTCTAGT 240

AAAGGGATCA TTTTAATTGA TGGCTATCCC AGGAGCGTGG AGCAAATGCA AGCTTTGGAT 300

AAGGAATTGA ACGCTCCAAA TGAAGTGATT TTAAAAAGCG TGATTGAAGT AGAAGTGAGC 360

GAAAACACCG CTAAAGAAAG GGTTTTAGGG CAGTTTTAG 399

(2) INFORMATION FOR SEQ ID NO: 462:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 462 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori ( ix ) FEATURE

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1 ..462

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 462:

ATGCATTATT CTTATGAAGC CTTTTTAAAA GACAGCCTGG AGTTAGCTAA ACAAGTGGAG 60

CGCCTTTGCG GTATCCCAGA AGCCCTTGTG TGCGTGATGC GAGGGGGCAT GACTTTAGTG 120

CATTTTTTGA GTTTGCACTG GAATTTAAGG GAAGTTTATG GCATCAATGC GATTTCTTAT 180

GACACCACCA AGCGACAAAA CGCCCTAAAA ATTGAAAATA CCCCCACGAT CAAAGATCAT 240

TTAAAAACCA TTTTAGTGGT AGATGAAATC GTAGATAGCG GTAATTCTTT GGAAGCGGTA 300

CTTAAAGTGT TGCAAGACAA ACACCCTGAT AAAAAGTTTT ATAGCGCGAG TTTGTTCCAA 360

AAAACAAGCG CGAAATACAA AGCCGATGCG TTTTTAAAAG ACGCTCCTGA ATGGATTGAT 420

TTCTTTTGGG AAGTGGATTT GAAAAACTTG AAAAGCCACT GA 462

(2) INFORMATION FOR SEQ ID NO: 463:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 708 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...708

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 463:

TTGTCTGAAC CCATAGATAG ATTCACACGC ATAAGGTGGT TGTTTAAAAA CGATTTTGAA 60

AAAATCCGCC AACAAAGGGT TTTAATCTGT GGCGTGGGGG GCGTTGGAGG CTTTGCACTA 120

GATTCTTTGT ATCGTGTGGG GATAGGGCAA ATCACTATCA TTGATAAAGA CATGTTTGAT 180

GTTACCAATC AAAACCGCCA GATTGGATCA GAAAGGATAG GAGAATCTAA AGTGTTGGTG 240

TTGCAAGATC TCTATAAAGG CATCCAAGCT TTAAATTGTC GCATAGATGA AGCGTTTTTA 300

AATTCATTTA ATTTTAGAGA TTATGATTAC ATTTTAGATT GCATGGACGA TTTGCCTATT 360

AAAACAAGCC TAGCGATAAA ATGTCAAAAT TTCGCTTACG GGAAGTTTAT CAGCTCTATG 420

GGGAGCGCGA AGCGTTTGAA TCCTAAACAC ATCCAAGTGG GGAGCGTGTG GGAAAGCTAT 480

GGCGATAAAT TCGGGCGTAA ATTTAGGGAT TTTTTAAAAA AACGCCGTTT TAAGGGGGAT 540

TTTAAGGTGG TTTTTAGCCC TGAAGTCCCG CATTGCATAG AGCTTGGAAG CTTTAATGCG 600

GTTACGGCGA GTTTTGGTTT GCAAATAGCG AGTGAAGTCG TGCAAGATAT TATCAAAAAT 660

GAAAGGCAAT GGAATGAAAG ATTACGAAGA CGAATTGGAA GATTTTGA 708

(2) INFORMATION FOR SEQ ID NO: 464:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1320 base pairs

(B) TYPE: nucleic acid (C) STRANDEDNESS double

(D) TOPOLOGY circular

(11) MOLECULE TYPE DNA (genomic)

(ill) HYPOTHETICAL NO

(iv) ANTI -SENSE NO

(vi) ORIGINAL SOURCE

(A) ORGANISM Helicobacter pylori

(ix) FEATURE

(A) NAME/KEY mιsc_feature

(B) LOCATION 1 1320

(xi) SEQUENCE DESCRIPTION SEQ ID NO 464

ATGCAAGTTA AAGAAAACAA ACAACTCTGC TTGATCTCAT TAGGTTGTTC TAAAAATTTA 60

GTGGATTCAG AGGTGATGTT AGGCAAGCTT TATAATTACA CGCTCACTAA TGACGCTAAA 120

AAAGCCGATG TGATCCTTAT CAACACTTGC GGTTTTATTG AAAGCGCTAA ACAAGAGAGT 180

ATCCAAACCA TTCTCAACGC AGCCAAAGAC AAAAAAGAGG GAGCGATTTT AATTGCGAGC 240

GGGTGCTTGA GCGAGCGCTA TAAAGATGAA ATCAAAGAAT TGATCCCTGA AGTGGATATT 300

TTTACCGGCG TGGGGGATTA TGACAAGATT GATATTTTAA TCGCTAAAAA ACAAAACCAA 360

TTCAGCGAGC AGGTGTTTTT AAGCGAGCAT TATAACGCGC GCATTATCAC GGGATCGAGC 420

GTGCATGCTT ACGTTAAAAT TTCTGAGGGC TGTAACCAAA AATGCTCTTT TTGCGCTATC 480

CCTAGCTTTA AGGGAAAATT ACAAAGCAGG GAATTAGACT CCATTTTAAA AGAAGTAGAA 540

GATCTAGCCC TTAAAGGCTA TAAAGATATG ACTTTTATCG CTCAAGATTC TAGCTCATTT 600

TTATACGATA AGGGGCAAAA AGACGGCTTG ATCCAGCTCA TTAGAGCGAT TGACAAACAG 660

CAAGCCTTAA AGAGCGCGCG TATTTTATAC CTCTACCCCT CTAGCACCAC TTTAGAGCTG 720

ATTGGCGCGA TTGAAGACTC GCCTATTTTT CAAAATTATT TTGACATGCC CATCCAGCAT 780

ATCAGCGACT CCATGCTTAA AAAAATGCGG CGCAACTCCA GCCAAGCACA CCATTTAAAG 840

CTTTTAAACG CCATGAAGCA GGTTAAAGAA AGCTTTATAA GAAGCACGAT CATTGTAGGG 900

CATCCAGAAG AAAATGAGAG CGAATTTGAA GAATTGAGCG CGTTTTTAGA CGAGTTCCGG 960

TTTGACAGAT TGAATATTTT TGCTTTCAGT GCTGAAGAAA ACACGCATGC CTATTCTTTA 1020

GAGAAAGTGC CTAAAAAAAT CATCAACGCC CGCATTAAAG CCTTGAATAA AATCGCTTTA 1080

AAACACCAAA ACCATTCTTT TAAGGCTTTG TTGAATAAGC CCATTAAGGC GTTAGTGGAA 1140

CATAAAGAGG GCGAATATTT TTACAAAGCA AGGGATTTGA GATGGGCGCC TGAAGTGGAT 1200

GGGGAAATTT TAATCAATGA CAGCGAACTA ACCACCCCTT TAAAACCCGG GCATTACACG 1260

ATTGTGCCTA GCGCCTTTAA AGACAATATT TTACTCGCTA AGGTTTTAAG CCCTTTTTAA 1320

(2) INFORMATION FOR SEQ ID NO 465

(l) SEQUENCE CHARACTERISTICS

(A) LENGTH 2004 base pairs

(B) TYPE nucleic acid

(C) STRANDEDNESS double

(D) TOPOLOGY circular

(ii) MOLECULE TYPE DNA (genomic)

(ill) HYPOTHETICAL NO

(iv) ANTI-SENSE NO

(vi) ORIGINAL SOURCE

(A) ORGANISM Helicobacter pylori (ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...2004

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 465:

AAAAAACCCT TTTACTCTCT CTCTCTCGCT TCATCGCTTT TAAACGCTGA AGACAACGGC 60

TTTTTTATCA GCGCGGGCTA TCAAATCGGT GAAGCCGCTC AAATGGTGAA AAACACCGGC 120

GAATTGAAAA AACTTTCAGA CACTTATGAG AATTTGAGCA ACCTTTTAAC CAATTTTAAC 180

AACCTCAATC AGGCGGTAAC GAACGCGAGC AGCCCTTCAG AAATCAATGC TGCGATCGAT 240

AATTTAAAAG CAAACACGCA AGGGCTAATT GGCGAAAAAA CCAATTCCCC GGCGTATCAA 300

GCGGTGTATT TGGCGCTCAA TGCGGCGGTA GGGCTGTGGA ATGTCATCGC CTATAATGTC 360

CAATGCGGTC CTGGTAACAG TGGACAACAA AGCGTAACCT TTGAGGGCCA ACCAGGACAT 420

AATTCAAGTT CCATTAATTG CAATTTAACC GGTTATAACA ACGGGGTTAG CGGCCCTTTA 480

TCCATTGAGA ATTTTAAAAA GCTTAATCAG GCTTATCAAA CTATCCAACA AGCTTTAAAA 540

CAAGATAGCG GATTTCCTGT TTTGGATAGT GCAGGAAAAC AAGTAACTAT AACAATAACA 600

ACGCAAACTA ATGGAGCTAA TAAAAGTGAA ACTACTACTA CTACTACTAC TACTAATGAC 660

GCTCAAACCC TTTTGCAAGA AGCCAGTAAA ATGATAAGCG TCCTCACTAC AAACTGCCCA 720

TGGGTCAATC ACAATCAAGG ACAAAACGGG GGCGCGCCGT GGGGTTTAGA TACGGCAGGG 780

AATGTGTGTC AGGTTTTTGC CACGGAATTT AGCGCCGTTA CTAGCATGAT CAAAAACGCC 840

CAAGAAATCG TAACGCAAGC TCAAAGCCTT AACCAGCAAA ACAATCAAAA CGCGCCGCAA 900

GATTTCAATC CTTACACCTC TGCTGATAGG GCTTTCGCTC AAAACATGCT CAATCACGCG 960

CAAGCGCAAG CCAAGATACT TGAGCTAGCC GATCAAATGA AAAAAGACCT TAACACTATC 1020

CCAAGCCAAT TTATCACAAA TTACTTGGCA GCTTGCCACA ATGGGGGTGG GACATTACCT 1080

GATGCGGGGG TTACTAACAA CACTTGGGGG GCCGGTTGCG CGTATGTGGA AGAGACGATA 1140

ACGGCTTTAA ACAACAGCCT TGCGCATTTT GGCACTCAAG CTGAGCAAAT CAAGCAATCT 1200

GAGTTGTTGG CGCGCACCAT ACTTGATTTT AGAGGCAGCC TTAGTAATTT AAACAACACT 1260

TATAACAGCA TCACCACGAC CGCTTCAAAC ACGCCTAATT CCCCATTCCT TAAAAATTTG 1320

ATAAGCCAAT CCACTAACCC TAATAACCCC GGGGGCTTAC AGGCCGTTTA TCAAGTCAAC 1380

CAAAGCGCTT ATTCGCAATT ATTAAGCGCC ACGCAAGAAT TAGGGCATAA CCCTTTCAGA 1440

CGCGTTGGAT TAATCAGCTC TCAAACCAAC AATGGTGCCA TGAATGGGAT CGGTGTGCAA 1500

GTGGGCTACA AACAATTTTT TGGTGAAAAG AGAAGGTGGG GGTTAAGGTA TTACGGCTTT 1560

TTTGACTATA ACCATGCTTA TATCAAATCT AGCTTTTTCA ATTCGGCTTC TGATGTGTTC 1620

ACTTATGGGG TAGGGACAGA TGTCCTCTAT AACTTTATCA ATGATAAAAC CACCAAAAAC 1680

AGCAAGATTT CTTTTGGGGT GTTTGGGGGG ATTGCGTTAG CTGGCACTTC ATGGCTGAAT 1740

TCCCAGTATG TGAATTTAGC GACCTTCAAT AATTTCTATA GCGCTAAAAT GAATGTGGCG 1800

AATTTCCAAT TCTTGTTCAA TTTAGGCTTG AGAATGAACC TCGCTAAGAA TAAGAAAAAA 1860

GCGAGCGATC ATGCGGCTCA GCATGGCGTG GAATTAGGCG TGAAGATCCC CACGATCAAC 1920

ACGAATTACT ATTCTTTGCT AGGCACTCAA CTCCAATACC GAAGATTGTA TAGCGTGTAT 1980

TTGAATTATG TGTTCGCTTA CTAA 2004

(2) INFORMATION FOR SEQ ID NO: 466:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 264 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: (A) ORGANISM : Helicobacter pylori

( ix ) FEATURE :

(A) NAME/KEY: misc_feature

(B) LOCATION 1...264

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 466:

ATGTTTATAC TTTTTAAGTT TGGTAGGGTT TTGGGTAAGG CTTATAGCTT ATACTTATAT 60

ATATATGAAA GCTTGATTTG TCAAGCTTTT GGGTTGTCAT TGAGTTGCAA TAACTCTATG 120

CTGTTTTCTA CTTTTTTGAT AAATCTACCA TTACCACACA ATGAGTCCTT ATGCTGTTGT 180

AGGGATATTT TAGCGTATTC TAACTCTTCA TCGCTAAAGA CATATTCATT GGAGTCAAAT 240

TTTTCTTTCA ATTCTTTATT TTGA 264

(2) INFORMATION FOR SEQ ID NO: 467:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 405 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...405

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 467:

ATGTTTATGG CGTCAATACG GACGCTGACG CACATGACTA ACGCTGATGG TACGATCACA 60

TGCGGAGACA CGACGCCGGC GAGTTGTAAT GTGGGGATTA ACCCTAACAG CGTCTATACC 120

ACAGGAAAAT TAAACGCTAA AGTGAATCAC ACGATTTTCC AATTTTTAGT GAATGTGGGC 180

ATTAGAACCA ATATTTTTGA ACACCATGGC ATTGAGTTTG GTATCAAAAT CCCCACGCTC 240

CCTAATTACT TTTTCAAAGG TTCTACTACT ATAAGAGCGA AAAAACAAGG CCCACTAGAG 300

AATGGGAACC CGACTACTAT CACCGGAGCA GAAACCAATT TCAGCTTAAC CCAAACCTTA 360

CGCCGTCAGT ATTCTATGTA TTTGCGTTAT GTTTATACTT TTTAA 405

(2) INFORMATION FOR SEQ ID NO: 468:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 837 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...837

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 468:

TTGAACAAAC TGCTTAAAAA GGGGTTTTTA GCGTTCTTTT TAAGCGTGTA TTTAAGGGCT 60

GATGATCTGG TTACTTATAC GATCGCCAAA GAAGAAGATC TAGGGTACCA GCGGTTTTTA 120

GCCAAGAAGT GTTTAAGGGG TAAAACCCAC CCCCCATGTT TTACCGCGTC TAAAAAGCCC 180

AAGAGGAAAC CTTTTAATAT AGATAAAAGC TCCCATTATT ATGGCACGAG CGTGGTGCAA 240

ATGTCATGGC TACAGAGTAG GGAAAAATTT GAAAACCATT CAAAATACCG AAACATTCCT 300

TTTGCTGAAG TCAGTTTGAT TTATGGCTAT AAACAATTTT TTCCTAAAAA AGAGCACTAC 360

GGCTTCCGTT TTTATGTCTC TTTGGATTAC GCTTATGGCT TTTTTCTTAA AAATAAAGGC 420

GCATTAGGCG ATAGTTTGAG GGCGAGTTCG CAGATCCCTA AAAGCTATAG AGAAAAATTA 480

CAAAGAAAAG AGACTTTTAT TAACGCTATT TTTTATGGCG TGGGGGCTGA CTTTTTATAC 540

AAACGCGCTT TTGGGACGCT GATTTTAGGG GTGAATTTCG TGGGAGAAAC CTGGTTTTAT 600

GAAACAAAGA TTTTCAAACA ATGGGCTAAA GACTCTCTAA ATACTTACCG CCCCAACATG 660

TTTCAAGTGA TGTTGAATGT GGGGTATCGC TACCGCTTTT CAAGGTATAA GAATTGGGCG 720

ATAGAATTTG GCGCGCGCAT CCCCTTTTTA ATTAATGATT ATTTTAAAAC CCCTTTATAC 780

ACCCTTCATT TCAAACGCAA TATTTCTGTC TATCTCACTT CAACTTATGA TTTTTAG 837

(2) INFORMATION FOR SEQ ID NO: 469:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1497 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1497

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:469:

ATGAAATTAA AAAAACGAAA AGTTGCGGCT ACATTGCTAA AGCGTTTGAC CTTGCCACTA 60

TTGTTCACTA CGGGTTCATT AGGGGCGGTT ACTTATGAAG TGCATGGGGA TTTTATCAAC 120

TTCTCCAAAG TGGGTTTTAA CCGTTCGCCT ATTAACCCTG TTAAAGGTAT CTATCCTACA 180

GAAACTTTTG TTAACCTTAC GGGTAAGCTA GAGGGGTCTG TGCATTTAGG TAGGGGATGG 240

ACCGTGAATG TAGGCGGTGT TTTGGGCGGA CAAGTTTATG ATAACACTAG GTATGATAGG 300

TGGGCAAAGG ATTTTACCCC CCCAAGCTAT TGGGATAAAA CTTCTTGCGG CACTGATTCT 360

TTGAGCCTTT GTATGAATGC GACTAAAATG TGGCAACAGC AAGGGCCAGG TGGTATCATT 420

GACCCTAGGG GTATTGGCTA TATGTATATG GGTGAGTGGA ACGGCTTGTT CCCTAATTAC 480 TATCCGGCTA ACGCCTACTT GCCCGGGCAT TCAAGGCGCT ATGAAGTTTA TAAAGCGAAT 540

CTTACCTATG ACAGCGACAG AGTCCATATG GTAATGGGGC GCTTTGATGT TACCGAGCAG 600

GAGCAAATGG ATTGGATTTA CCAATTGTTC CAAGGTTTTT ATGGGACTTT CAAGCTTACT 660

AAGAACATGA AATTCTTGCT CTTTAGCTCT TGGGGTCGTG GTATCGCTGA TGGTCAATGG 720

TTGTTCCCTA TCTATCGTGA AAAGCCTTGG GGTATTCATA AGGCGGGTAT TATTTATCGC 780

CCTACAAAGA ATCTAATGAT CCACCCTTAT GTGTATCTCA TCCCAATGGT AGGTACATTG 840

CCCGGTGCTA AAATAGAATA CGATACCAAT CCTGAGTTTA GCGGTAGAGG TATAAGGAAT 900

AAAACGACTT TCTATGTGTT GTATGACTAT CGTTGGAATA ACGCTGAATA CGGCCGTTAC 960

GCACCCGCTC GTTATAACAC TTGGGATCCG TTCTTGGATA ATGGTAAGTG GCGTGGCTTG 1020

CAAGGTCCTG GTGGTGCGAC GCTCTATTTG CACCACCACA TAGACATTAA CAACTACTTT 1080

GTGGTTGGTG GTGCTTACCT CAACATCGGT AACCCTAACA TGAACTTAGG TACTTGGGGT 1140

AACCCTGTGG CTCTTGATGG TATCGAACAA TGGGTCGGTG GCATCTACAG CTTAGGCTTT 1200

GCGGGGATTG ACAACATTAC CGATGCTGAT GCGTTCACTG AGTATGTTAA AGGTGGAGGT 1260

AAGCATGGTA AGTTCAGTTG GAGCGTTTAT CAGCGCTTCA CTACCGCACC AAGGGCTTTG 1320

GAATATGGTA TTGGTATGTA TCTAGACTAT CAGTTCAGCA AGCATGTTAA AGCGGGTCTC 1380

AAACTCGTGT GGTTAGAGTT CCAAATCCGT GCGGGTTACA ACCCTGGAAC CGGTTTCCTT 1440

GGGCCAAACG GTCAGCCGCT CAACTTGAAT AATGGTTTGT TTGAATCTTC GGCGTTC 1497

(2) INFORMATION FOR SEQ ID NO: 470:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 207 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...207

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 470:

TTGAAAGAAA AATTTGATTT TTTTAAAGGC AAAAATTTTA AAATTGTCTA TTGTATTGGC 60

GAAGATTTAA CGACCAGAGA AAAGGGTTTT AGGGCTGTAA AGGAATTTTT AAGCGAGCAA 120

TTAGAAAATA TTGATCTTAA TTATTCCAAT TTAATTGTGG CTTATGAGCC TATTTGGGCG 180

ATTGGCACTA AAAAAGCGCG CTTTTAG 207

(2) INFORMATION FOR SEQ ID NO: 471:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 792 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO ( iv ) ANTI - SENSE : NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...792

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 471:

ATGAGTAAGA GCGCGATTTT TGTTCTTTCT GGCTTTTTAG CGTTCTTGCT CTATGCTTTG 60

TTATTATATG GTTTGTTGTT AGAAAGGCAT AATAAAGAAG CAGAGAAAAT CCTTTTAGAT 120

TTAAATAAAA AGGACGAACA AGCCATTGAC TTGAATTTAG AAGATCTGCC AAGCGAGAAA 180

AAGAATGAAA AAATTGAAAA AGTAACGGAA AAACAGGGCG ATTTTTTAGA GCCTAAAGAA 240

GAACCCAAAG AAGAGCCTGA AGAAAGCCTT GAAGATATTT TTTCTTCACT CAATGATTTT 300

CAAGAAAAGA CAGACAAAAA CGCTCAAAAA GACGAGCAAA AAAATGAACA AGAAGAACAA 360

AGGCGTTTAA GAGAGCAACA ACGCTTGAAA CAAAACCAAG AAAACCAAGA GATGTTGAAA 420

GGTTTGCAAC AAAATTTGAA TCAATTCACG CAAAAATTAG AAAGCGTTAA AAACAAGACT 480

TTAGATTTGC AAATCCCTAA ACAAGATGGG GTTGATGAAA AGGCTTATCA AGAGTGGTAC 540 GCTCAAATCT ATCAAATTTT ATATAAAGGC TGGAGGGGCG TTTTTTATCA CAAGGCTTCA ^' 600

GTGAGCGTGC TGATTATGAT CACTAAAGAT GGAGAGTTTG ATTATACCAT TCTTAGCTAC 660

TCTGATTTTA AGGATTATAA CAAGAGCGTG ATGACCCTTT TAGATGATTT AAAGAAAGTG 720

GATTTCCCCC CATATCCTGG AGGAAACATG ATTTCTATTA AAGTTAATTT TACGACTAAG 780

GAAGAACAAT GA 792

(2) INFORMATION FOR SEQ ID NO: 472:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2355 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...2355

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 472:

ATGGAGCAGC CAGTCATTAA AGAAGGGACT TTAGCTTTAA TTGATACCTT TGCGTATTTG 60

TTTAGAAGCT ATTACATGAG CGCTAAAAAT AAGCCTTTAA CCAACGATAA GGGCTTTCCT 120

ACAGGGCTTT TAACGGGGCT TGTGGGCATG GTTAAAAAAT TTTATAAAGA CAGAAAAAAC 180

ATGCCTTTTA TCGTGTTCGC CCTAGAAAGC CAGACTAAAA CTAAAAGAGC TGAAAAACTG 240

GGCGAATACA AACAAAATCG TAAAGACGCC CCTAAAGAGA TGCTTTTACA AATCCCTATC 300

GCCTTAGAAT GGTTGCAAAA AATGGGTTTT ACTTGCGTGG AGGTGGGAGG GTTTGAAGCC 360

GATGATGTGA TCGCAAGTTT AGCCACGCTA AGCCCTTATA AAACCCGCAT TTATTCTAAA 420 GATAAGGATT TTAACCAGCT TTTGAGCGAT AAAATCGCGC TTTTTGATGG CAAAACGGAG 480

TTTTTGGCGA AAGATTGCGT GGAAAAATAC GGGATTTTGC CGAGTCAATT CACGGATTAT 540

CAGGGCATTG TGGGGGATAG CAGCGATAAT TACAAGGGGG TTAAAGGCAT TGGGAGCAAG 600

AACGCTAAGG AATTGTTGCA GCGATTAGGG AGCTTGGAAA AAATCTATGA AAATTTAGAC 660

TTGGCGAAAA ATTTACTCAG CCCTAAAATG TATCAAGCCT TGATACAAGA CAAAGGAAGC 720

GCCTTTTTAA GCAAAGAATT AGCCACTTTA GAAAGAGGAT GCATTAAAGA ATTTGATTTT 780

TTAAGTTGCG CTTTTCCGAG CGAAAACCCC TTGTTGAAAA TCAAAGATGA ATTGAAAGAA 840

TATGGTTTCA TTTCTACCTT AAGGGATTTA GAAAATTCCC CTTTCATTGT AGAAAACGTG 900

CCCATATTAA ACAGCACGCC TATATTAGAC AATACCCCCG CCTTAGACAA CGCCCCTAAA 960

AAATCGCGCA TGATTGTTTT AGAAAGCGCT GAGCCTTTGA GCATGTTTTT AGAAAAATTA 1020

GAAAACCCTA ACGCTAGGGT TTTTATGCGT TTGGTTTTGG ATAAAGACAA AAAAATTCTA 1080

GCCCTAGCGT TTTTATTACA AGATCAAGGC TATTTTTTAC CTTTAGAAGA GGCGTTGTTT 1140

TCGCCCTTTT CTTTGGAATT TTTACAAAAC GCTTTTTCTC AAATGTTACA GCATGCGTGT 1200

ATCATTGGGC ATGATTTAAA GCCTTTATTA AGCTTTTTAA AAGCCAAATA TCAGGTGCCT 1260

TTGGAAAATA TCCGCATCCA AGACACTCAG ATTTTAGCGT TTTTAAAGAA TCCGGAAAAA 1320

GTGGGGTTTG ATGAGGTTTT AAAGGAATAT TTAAAAGAAG ATTTAATCCC GCATGAAAAG 1380

ATCAAAGATT TTAAGACAAA AAGTAAGGCG GAAAAATCAG AACTTTTAAG CATGGAATTA 1440

AACGCCTTAA AGCGTTTGTG CGAATACTTT GAAAAAGGGG GGCTAGAAGA GGATTTGCTC 1500

ACTTTAGCTA GAGACATTGA AACGCCGTTT GTGAAAGTTT TAATGGGCAT GGAATTTCAA 1560

GGCTTTAAGA TTGATGCGCC TTATTTCAAG CGCTTAGAGC AGGAGTTTAA GAATGAATTA 1620

AACGTTTTAG AGCGCCAAAT TTTGGATCTA ATCGGCGTGG ATTTCAACCT CAATTCGCCC 1680

AAGCAACTTG GCGAAGTCTT GTATGATAAA TTAGGGCTTC CTAAAAATAA AAGCCACTCT 1740

ACCGATGAAA AAAACTTGTT AAAAATCCTA GACAAGCACC CAAGCATCCC TTTGATTTTA 1800

GAATACAGGG AATTGAATAA GCTTTTTAAC ACTTACACGA CCCCCTTATT GCGCTTAAAA 1860

GACAAAGACG ATAAAATCCA TACCACTTTC ATCCAAACCG GCACAGCTAC CGGGCGTTTA 1920

AGCTCGCATT CGCCTAATTT GCAAAATATC CCGGTGCGAT CGCCTAAAGG CTTACTCATT 1980

CGTAAGGGTT TTATCGCTAG CTCTAAAGAA TATTGTTTAT TAGGGGTGGA TTATTCGCAG 2040

ATTGAATTAC GCTTGTTGGC CCATTTCAGC CAGGATAAGG ATTTAATGGA AGCGTTTTTA 2100

AAGGGGCGAG ACATCCATTT AGAAACTTCT AAGGCGTTGT TTGGAGAAGA TTTAGCCAAA 2160

GAAAAACGAT CCATCGCTAA AAGCATTAAT TTTGGGCTGG TGTATGGCAT GGGGAGTAAG 2220

AAATTGAGCG AAACTTTAAG CATCCCTTTA AGTGAGGCTA AAAGTTACAT AGAAGCGTAT 2280

TTCAAGCGAT TCCCTAGCAT TAAAGATTAT TTGAATGGCA TGCGAGAAGA GATTTTAAAA 2340

ACTTCTAAAG CTTTT 2355

(2) INFORMATION FOR SEQ ID NO: 473:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 168 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...168

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 473: GTGAGCGAGA GCGAAAAACA AGAAATTGAA AACAAGATAG AAGAAAGAAA ACGTGCCAAA 60

GAACAAAAAG ATTTTTTAAA AGCCGATAGC ATCAGAGAAG AGCTTTTACA ACAAAAAATC 120

GCTTTGATGG ACACCCCACA AGGCACGATT TGGGAGAAGC TTTTTTAA 168

(2) INFORMATION FOR SEQ ID NO: 474:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1716 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1716

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 474:

TTGCCGAGCG TTCAAATATG GGGGAGCTAC ACTAACTCGT TTAAACAAAC CTTTAGCGCA 60

AGTAATAGCA ATCTGGTGAT TGGGTATAAC GCAACATGGA CTGATCCCAA TGTTTCTTCT 120

AGCGACACGG TGGCTTTTGG GGACCCTTCA GGGAGCGCTC TTAATGGGCA TTGCGGGCCT 180

TGGCCCTATT ACCAATGCAC AGGCACGACT AACGGCACTT ATAGCGCTTA TCATGTCTAT 240

ATCACAGCGA ATCTGCGTTC TGGCAATCGT ATAGGCACCG GTGGGGCAGC CAATCTAATC 300

TTTAATGGGG TAGATAGTAT CAATATCGCT AACGCTACCA TCACGCAACA TAACGCCGGG 360

GCTTATTCAA GCTCTATGAC TTTTTCCACG CAAAACATGG ACAATTCGCA GAATTTGAAT 420

GGCCTAAATT CTAACGGCAA GCTTTTGGTG TATGGCACAA CTTTCACTAA CCAAGCCAAA 480

GACGGGAAAT TCATTTTCAA TGCAGGGCAA GCGACTTTTG AAAACACCAA CTTTAATGGA 540

GGGAGTTACC AATTCAGCGG CGATAGCTTG AATTTTTCAA ATAACAACCA GTTCAATAGC 600

GGTTCGTTTG AGATTGGCGC AAAAAATACT ATTTTTAATA ACGCTAATTT TAACAACAGC 660

ACTTCTTTTA ATTTCAATAA TTCTAGCGCG ACCACTTCGT TTGTGGGGGA TTTCACTAAC 720

GCTAATTCAA ATTTGCAAAT CGCTGGGAAC GCTGTTTTTG GGAACTCTAC TAATGGCTCT 780

CAAAATACCG CTAATTTTAA TAATACCGGC TCTGTTAATA TTGCAGGGAA TGCAACCTTT 840

GATAACGTGG TATTTAACAG CCCTACGAAC ACGAGCGTGA AAGGGAAAGT TACTCTCAAT 900

AACATCACTT TAAAAAACTT GAACGCTCCT TTGTCTTTTG GCGATGGGAC GATTGTTTTT 960

AGCGCTCATT CGGTGATTAA TATTGGTGAA GCTATCACAA ATGGCAACCC TATCACCCTT 1020

GTAAGCTCTT CTAAAGCAAT TGAATACAAC GACGCTTTCA GTAAAAATCT ATGGCAGCTC 1080

ATCAACTACC AAGGGCATGG GGCTAGCAGT GAAAAGCTCG TTTCTAGTGC GGGTAATGGC 1140

GTCTATGATG TGGTGTATTC TCTCAACAAC CAAACCTACA ATTTCCAAGA GGTTTTTTCA 1200

CCCAACAGCA TTTCTATCCG GCGTTTGGGC GTTGGCATGG TGTTTGATTA TGTGGATATG 1260

GAAAAATCGG ATCGTTTGTA TTATCAAAAC GCTCTCGGTT TTATGACCTA CATGCCTAAT 1320

AGCTATAACA ATAATTTAGG GAATTTAAAC AACACCATTT ACTATTACGA CAACAGCATT 1380

GACTTTTATG CGAGCGGGAA AACTCTATTC ACTAAAGCGG AATTTTCTCA AACGTTCACT 1440

GGGCAAAACA GCGCGATCGT TTTTGGGGCT AAAAATATAT GGACGAGCGT AAGCGATGCG 1500

CCGCAATCTA ATGTGATCAT TCGCTTTGGG GACAATAAGG GAGCAGGGAG TAATGATGCG 1560

AGTGGGCATT GCTGGAATTT GCAATGCATA GGCTTTATCA CAGGGCATTA TGAAGCGCAA 1620

AAGATTTACA TCACCGGCAG TATTGAAAGC GGGAACCGCA TTTCTAGCGG TGGGGCGCGA 1680

GCCTTAATTT TAACGGGCTT CAAGGCATTC TTTTAA 1716 (2) INFORMATION FOR SEQ ID NO.475

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1107 base pairs

(B) TYPE- nucleic acid

(C) STRANDEDNESS. double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE- NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...1107

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 475:

ATGGTTGTTT TAGGAAGCAC CGGCTCTATC GGGAAAAACG CCCTTAAAAT CGCAAAAAAA 60

TTTGGTGTAA AAATAGAAGC CTTAAGCTGT GGGAAAAATA TCGCTTTAAT CAATGAACAA 120

ATCAAAGTTT TCAAACCCAA AAAAGTAGCG ATCTTAGATC CTAACGATTT GAATAATTTA 180

GAGCCTTTGG GCGCGGAAGT GTTTGTGGGG TTAGACGGCA TTGATGCGAT GATAGAGGAG 240

TGCGTTTCCA ATTTAGTCAT TAACGCCATT GTGGGCGTAG CCGGATTGAA AGCGAGCTTT 300

AAAAGCTTAC AAAGGAACAA AAAACTAGCC CTAGCGAATA AAGAAAGTTT AGTGAGCGCG 360

GGGCATTTAT TAGACATTTC ACAAATCACG CCCGTTGATA GCGAGCATTT TGGTTTGTGG 420

GCGTTGTTGC AAAACAAGAC TTTAAAGCCT AAATCTTTAA TCATTAGCGC GAGTGGGGGG 480

GCTTTTAGGG ACACGCCCTT AGATCTTATC GCTATTCAAA ATGCGCAAAA CGCGCTCAAG 540

CACCCTAATT GGAGCATGGG GGATAAAATC ACCATTGATT CAGCGAGCAT GGTCAATAAA 600

CTTTTTGAAA TTTTAGAAAC CTATTGGCTT TTTGGTGCGT CTTTAAAGAT TGACGCGCTG 660

ATTGAAAGAA GTTCTATCGT GCATGCTTTG GTGGAGTTTG AAGACAACTC TGTCATTGCG 720

CATTTAGCGA GTGCGGACAT GCAATTACCC ATAAGCTATG CCATTAACCC TAAATTAGCT 780

TCTTTGAGTG CTTCCATTAA ACCCTTAGAT TTATACGCTT TAAGCGCGAT TAAATTCGAA 840

CCCATTAGCG TGGAGCGCTA CACTTTGTGG CGTTATAAAG ATTTGTTGTT GGAAAACCCA 900

AAGCTTGGCG TGGTGCTGAA TGCGAGCAAT GAAGTGGCGA TGAAGAAGTT CTTGAATCAA 960

GAAATCGCTT TTGGTGGCTT TATCCAAATC ATCTCTCAAG CTTTAGAATT GTATGCTAAA 1020

AAATCTTTCA AGCTCTCTAG TTTAGATGAA GTGCTAGCGT TAGATAAGGA AGTTAGGGAG 1080

CGTTTTGGAA GTGTAGCGAG AGTGTAG 1107

(2) INFORMATION FOR SEQ ID NO: 476:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 261 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (ill) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...261

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 476:

ATGAAAACGA CAGAAAACAC AGATGAAACT CACTTAAGGG AAACTAAAAA TAAACTAGGA 60

CGCAAACCAA AAGCAGACGC TAATAAAAAA ACTCGCGCGG TAAGCTTGTA TTTTTCTGAT 120

GAGCAATACC AAAAACTAGA GAAAATGGCT AACGAAGAAG AAGAAAGCGT GGGATCTTAT 180

ATCAAACGCT ATATTTTGAA GGCTTTAAGA AAAATAGAAC AAGGTGGTGG CTTTATAGCT 240

TTTAACTTGT TTTTAATTTA A 261

(2) INFORMATION FOR SEQ ID NO: 477:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2412 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...2412

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 477:

TTGTGGCTTA AGTCAAAATT CTTTCTTTTA ATGGGCGTGG GTTTGCTCTC CCATTCACTC 60

AACGCTTTAA GCCTCACGCT CACGCAAGGC AAAGAAGAAG GAGAAGATTT TTCGGTTTTA 120

ACCTTACGAA ACGATAAGGC GTTTTCTTGC TCTTATGCTA ATGAAAAACC GCCGAGCGGG 180

ATTGAAGCGT CTTTATCTAT TATACACGCT AAACGCCCCA TAGAATGCGT GATAGATTCT 240

ATTCCTAAAG AGGGCTTTAC CCCTTTAGAA AACGCTTTTT TCAATATCAC CTATTCCATG 300

CGCCAGCAAC AATTCATTTT ACACATCAAA CCCAAAGTGA TGCGAAGGCT CACCCTTTTT 360

TCTTTTGATA GGGATTATAA AAAAGCGATC CCCCTTTTTG TGGAAAACGA CGCTAAAGCC 420

AAGATGTGGC AAATCATAGG CTATGATCAA AAAATCCCTT TTTTGAGCGA AAAAGACAAC 480

GCTCAAAAAG GCTTGAATTT CCCCATTATC ATTAAAGACG CTCAAACCCC TATCATTCAA 540

GAGCTGGATG TGAATAACAA ACCCCTACTC ACCACAAAGG GCTATGATTT AAACGCCTAT 600

TTAGAAGCTA AAAAACAAAT GGATTCGCAA GCCTATTTTG ACGCCTTACG CACGATCAGC 660

CGCGCGTTTA AAAATTACCC TCAAACGATT TTTAAAAAAG ATCTGTATTT ATTAGAAATT 720

ATCGCATTAG GTAAATTAGG CATTAAAAAA TCCTTACTCA TAGATATTGG CACCCAATGG 780

ATTAAAAATT ACCCGACTGA TCCTAATATC CCTGAAGCGC TATACTATGT CGCCAAAGCT 840

TTAGATGAAA ACAACAATTA CAAACAAGCC GTGCGCTATT ACAAACGAAT CCTTTTAGAA 900

TACAAAAACT CCCGCTACGC TCCCTTAGCC CAAATGCGTT TAGCCATTGA AGCGGCTGAA 960

GGCTCTGATT TGAGCAACGC TAATATGCTT TTTAAAGAAG CTTTTTCTAA CGCCAAAGAC 1020

AAAGAGAGCG CGAGTGAAAT CGCGCTTAAT TGGGCTGAAG CAGAGATAAA CTATCAAAAC 1080

TTTAATAACG CTAAATATCT CATTGATAAG GTGGTTCAAT CCAACCCTGA TTATCTTTCT 1140 ATGCACAGCG AATTAGCCCT AGAATTGCTC AAGTTATTGA AAAAAAACCA AATGAATGAA 1200

AGTGCGATTG AGATCGCTCA CTTGCTCCTC AATCAAGATG ATGACTTGAA AGCTAAAGAG 1260

CAAGCGCTCT ATGATTTAGG GGCGTTGTAT GCAAGGATCA AGGATTTTAA AAACGCCCAC 1320

CTTTACAATC TGCAATATTT GCAAGACCAT GCGGAATTGG AGCGGGCTTC TGTCGTTAGA 1380

GCACGCGATG AAAAAGCCCT TTTTTCAATG GAAGGGAACA CGCAAGAAAA AATCGCCCAC 1440

TACGATAAAA TCATTCAAAA TTTCCCTAAT TCTAATGAAG CCCAAAAGGC TTTAGAGTTG 1500

AAAGCCCAAC TCTTGTTTGA CAATAAGCAC TATGCTGAAG TTTTAGGCAT GCAAAAAAAT 1560

TTGCCCAAAG ATTCTCCCTT GATCCAAAAA ACGCTCAATA TCCTTGCTAA AACCCCATTA 1620

GAGGATCATC GTTGCAAAGA AGCTTTAAAA TACTTATCCC AGATCACCGC CTTTGCATTC 1680

AACCCCCAAG AAGAAATCCA AGCCTTTGAT TGCTTGTATT TCGCATCGCT CAAGGAAAAA 1740

GCGCAAATTA TTGCCCTAAA CGCTTTAAAA GCGGCTAAAA CCCCTAGCGA GAAATTAACA 1800

TGGCTTTATC GTTTGGGGCG CAATTACTAC CGCTTAGGGG ATTTTAAAAA TTCCACTCTG 1860

GCTTCTAAAG ACGCCTTAAT CCTCGCTCAA AGCTTAAATA AAAAAGAGTT TTATGACATT 1920

GCTTTTGTGT TATTTTCAGA TTACATGCAA AACAATGAAA AAGGATTGGC CCTCAATTTG 1980

TATGCGTTTT TAGAAAAGCA TTTCAAAGAC GATAAACGCA TGGCGTTGGT TTATTTTAAA 2040

TTATTAGAGA ATGAAAAAGA CCCTAAAAGC GTTAAAATTT ATGCCACAAG CTTACTCAAA 2100

CTCCAAGACG CTTATAAGGA TTATTCTTAC ACGCCCTTTG GCGAATTTGC CCTTATTGAC 2160

GCTTACAGAA CCACCAAAGA TTATTCAAAA GCGTTAGAAA CGCTAGACAA ACTCTTAAAC 2220

CGCAGGCTTT CTTTAGAAGA TCACCAAAAA GCCTTATACT TGCAATCCAG CTTATTGGAT 2280

TTAACCAATC AAAAAGCAAA ATCTAAAGCC AGTTTAGAAA AATGCGTTCA ATTAAAGCAA 2340

AAAGATCAAA CAAACGCATG GCAAAATTTA TGCGAACAGG GTTTAAATTT ATTCAAAAAC 2400

AAGGAGTCAT GA 2412

(2) INFORMATION FOR SEQ ID NO: 478:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 798 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...798

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:478:

ATGATATTAA GAGCGAGCGT GTTGAGCGCG TTACTTCTTG TAGGCTTAGG GGCAGCCCCT 60

AAACATTCAG TTTCAGCTAG TGACAAACGG ATGCAGGATA ATTTAGTGAG CGTGATTGAA 120

AAACAAACCA ATAAAAAGGT GCGTATTTTA GAAATCAAAC CTTTAAAATC CAGCCAGGAT 180

TTAAAAATGG TCGTTATTGA AGATCCGGAC ACTAAATACA ATATCCCGCT TGTAGTGAGT 240

AAGGATGGTA ATTCAGTCAT AGGGCTTAGC AATATCTTTT TTAGCAATAA AAGCGATGAT 300

GTGAAATTAG TTGCAGAAAC CAATCAAAAA ATCCAAGCCC TTAACGCTAC CCAGCAAAAC 360

AGCGCGAAAT TGAACGCTAT TTTTAATGAA ATACCGGCTG ATTATGCGAT AGAGTTGCCC 420

TCTACTAACG CTGAAAATAA GGATAAAATC CTTTACATTG TTTCTGATCC CATGTGCCCG 480

CATTGCCAAA AAGAGCTCAC TAAACTCAGG GATCACTTAA AAGAAAACAC TGTGAGAATG 540

GTTGTAGTGG GGTGGCTTGG AGTCAATTCG GCTAAAAAAG CGGCTTTGAT CCAAGAAGAA 600

ATGGCGAAAG CTAGGGCTAG GGGAGCGAGC GTGGAAGATA AAATCTCTAT TCTTGAAAAG 660 ATTTATTCCA CCCAATACGA TATTAACGCT CAAAAAGAGC CTGAAGATTT ACGCACTAAA 720 GTGGAAAATA CCACTAAAAA GATTTTTGAA TCTGGCGTGA TTAAGGGTGT GCCTTTCTTG 780 TATCATTATA AGGCATGA 798

(2) INFORMATION FOR SEQ ID NO: 479:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 684 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...684

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 479:

TTGGATTTTA AAGCGATAGA GCATGGAGAG GAAACCCTAA AAAACGAGAC TTTAAGAGCG 60

TTAAGCGATT TTGCGAAGTC TAGCGATACG CATATCGTGG CATGCAGTAT TGAAAAAAAT 120

AATAAAAAAC TTTACGATAG CGCTTATATC ATTCCACCAA AAGGAAAAAT CGTTGGCAAA 180

CACCGCAAGA TCTATTTGTG GGGCGATGAA AAATCGCGCT TCAAAAGGGG TAAAAAATAC 240

GAGGTTTTTA CGCTGGATTT TGGGGATTTT AGCGCGAAAG TGGGTTTGCA AATTTGCTAT 300

GAAACTGGCT TTGGCGTGGG TGCGAACCTG CTTGTGTTAC AAGGGGCTGA GGTTTTAATC 360

TATCCTAGTG CGTTTGGCAA AGCTAGGGCT TATAATTGGG ATTTGTTGAG CAAAGCTAGA 420

GCGTTAGAAA ATGGCTGTTT TGTGTGCGCT TGCAATCATA GTGGGGAAGA AACTAACGCT 480

AAATTAAAAC AAACGCTAGA ATTTGCCGGT GATTCAAGAA TCATCGCACC CAATGGGAAA 540

ATCATCGCCC AAGCCACCAA GCTTAATGAA GTCATTATCG CCGAAATGGA TTTAAACGAA 600

GTGGCACTGC AACGCCAAAA AATCCCTTAT TTACAAGATT TTGACACCAA ACTCACCAAA 660

AAGGGGTTTG GAAAACTCAC TTAA 684

(2) INFORMATION FOR SEQ ID NO: 480:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 882 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori ( ix ) FEATURE :

(A) NAME/KEY: misc_feature

(B) LOCATION 1...882

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 480:

ATGGCAAAAG AAATTTTAGT GGCTTATGGC GTGGATATTG ATGCGGTGGC TGGTTGGCTG 60

GGGAGCTATG GTGGGGAGGA TTCGCCTGAT GATATTTCGC GTGGGCTTTT TGCGGGGGAA 120

GTGGGGATCC CACGGCTTTT GAAATTGTTT AAAAAATACC ATCTCCCTGC GACTTGGTTT 180

GCGCCGGGGC ATTCTATTGA AACTTTTCCT GAACCAATGA AAATGATCGT GGATGCAGGG 240

CATGAAGTGG GTGCGCATGG GTATTCACAC GAAAACCCTA TCGCTATGAC GGCCAAGCAA 300

GAAGAAGACG TTTTGTTAAA AAGCGTTGAA TTGATTAAAG ATCTCACCGG CAAAGCCCCC 360

ACAGGCTATG TGGCGCCGTG GTGGGAGTTT TCTAATATCA CTAATGAATT GCTTTTAAAA 420

CACGGCTTCA AATACGACCA TTCGCTCATG CACAATGATT TCACGCCCTA TTTCGTGCGC 480

GTGGGGGATA GTTGGAGCAA GATTGATTAT AGTTTGGAGG CCAAGGATTG GATGAAGCCT 540

TTAATCCGTG GGGTGGAAAC AAATTTAGTG GAAATCCCTG CGAACTGGTA TTTGGACGAT 600

TTACCGCCGA TGATGTTTAT CAAAAAATCC CCCAATAGCT TTGGTTTTGT AAGCCCGCGC 660

GATATAGGGC AAATGTGGAT CGATCAATTT GATTGGGTTT ATCGTGAGAT GGATTATGCG 720

GTGTTTAGCA TGACAATCCA CCCTGATGTG AGCGCCCGTC CGCAAGTGTT GCTCATGCAT 780

GAAAAAATCA TTGAGCATAT CAACCAGCAC GAGGGCGTGC GTTGGGTAAC GTTCAATGAA 840

ATCGCTGATG ATTTCTTAAA ACGAAACCCT AGGAAAAAAT AG 882

(2) INFORMATION FOR SEQ ID NO: 481:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 411 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...411

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:481:

GTGTGCGGCG TATTATCGTT ACAAGCGCGT TTGAGCTTTG AAAATTGCTC TAAGCCCCTA 60

GACTGCTCAC TATTCGCTAC AACTTGCACC CCGCAAAACC CGATCGGCAG TTGCATGGTC 120

AGCTCTCAAG GGGGCGTGTG CGGCGTATTA TCGTTACAAG CGCGTTTGAG CTTTGAAAAT 180

TGCTCTAAGC CCCTAGACTG CTCACTATTC GCCACAACTT GCACCCCGCA AAACCCGATC 240

GGCAGTTGCA TGGTCAGCTC TCAAGGGGGC GTGCGCGGCG TATTATCGTT ACAAGCGCGT 300

TTGAGTTTTA AAAATTGCTT TTTAGTGAAA TCGCTCAAAC CCTCGCAATT GACATTGATG 360

CTAACCGGTT TTTTAGGGGG GTTTTCTTTT TTGACAACCG GTTTTTGGTA A 411

(2) INFORMATION FOR SEQ ID NO: 482:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1083 base pairs (B) TYPE: nucleic acid

(C) STRANDEDNESS. double

(D) TOPOLOGY, circular

(11) MOLECULE TYPE. DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: raiscjeature

(B) LOCATION 1...1083

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 482:

ATGAATGGTT TTTGCGCTAG ACTACGAGCC ATAACATTTA ATGAAAGACT AAAAATGAAA 60

ATAGCGGTAT TACTCAGTGG GGGGGTGGAT AGCTCTTATA GCGCTTATAG CTTAAAAGAG 120

CAAGGGCATG AATTAGTGGG GATTTATTTA AAACTCCATG CGAGTGAAAA AAAGCATGAT 180

TTATACATTA AAAACGCTCA AAAAGCGTGC GAGTTTTTAG GCATTCCTTT AGAGGTGTTG 240

GATTTTCAAA AGGATTTTAA AAGCGCGGTT TATGATGAAT TTATCAACGC CTATGAAGAA 300

GGGCAAACCC CTAACCCATG CGCGTTGTGC AACCCTTTAA TGAAGTTTGG GCTAGCTTTA 360

GATCACGCTT TAAAATTAGG GTGTGAAAAG ATCGCTACCG GGCATTATGC GAGGGTCAAA 420

GAAATTGACA AGGTAAGTTA TATTCAAGAG GCTTTGGATA AAACTAAAGA TCAGAGCTAT 480

TTTTTATACG CTTTAGAGCA TGAAGTTATC GCTAAATTGG TGTTCCCTTT AGGGGATTTG 540

CTAAAAAAGG ATATTAAGCC TTTAGCCTTG AATGCGATGC CCTTTTTAGG CACTTTAGAA 600

ACTTATAAGG AATCTCAAGA AATCTGCTTT GTGGAAAAAA GCTACATTGA CACTTTAAAA 660

AAGCATGTTG AAGTGGAAAA AGAGGGCGTG GTGAAAAACC TACAAGGCGA AGTCATTGGC 720

ACGCATAAAG GCTATATGCA ATACACGATT GGCAAACGCA AAGGCTTTAG TGTTAAAGGC 780

GCGTTAGAGC CGCATTTTGT GGTGGGGATT GACGCTAAAA AGAACGAGTT GATTGTGGGC 840

AAAAAAGAAG ATCTCGCCAC GCATTCGCTT AAGGCTAAAA ACAAATCTTT AACGAAAGAT 900

TTTAAAGATG GCGAATACTT CATCAAGGCC CGTTACAGGA GCGTGCCTAC TAAAGCGTTT 960

GTGAGCTTAA AAGATGGAAT GATTGAAGTG GAATTTAAAG AGCCTTTTTA CGGCGTGGCT 1020

AAAGGGCAAG CCTTGGTCGT TTATAAAGAT GATATTTTGC TTGGCGGGGG CGTGATTGTT 1080

TAA 1083

(2) INFORMATION FOR SEQ ID NO: 483:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1074 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE: (A) NAME/KEY: misc_feature

(B) LOCATION 1...1074

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 483:

ATGAAAGCTA GCATTTATGA TTTCACTTTA GATGAATTGA GCCAACTTTT AAAACCAAGT 60

TTTAGGGCTA AACAGCTTTA TTTGTGGCTC TATGCGAAGT ATAAAACAAG CTTTAAAGAC 120

ATGCAAAATA ATTTTTCAAA AGACTTTATC GCTTATTTGG AGCAAGAATT TACTTTGCGC 180

ACGATAGAAA TCGCGCATGT GAGGGAGAGT GTTGATGGCT CTAAAAAATA CCTTTTTAAA 240

TCTTTAAGGG ACAACCACAC TTTTGAAGCG GTGTTGTTGA AAATGAAAGA CAAAAAGATT 300

GATGAAGAAA CGAACGCCGT TTTAGAGGGG GAAAAATACA CCGTGTGCGT GTCTTGTCAA 360

ATCGGCTGTC AAGTGGGTTG CTCGTTTTGT TTCACTCAAA AAGGCGGTTT TGTAAGGGAT 420

CTCAAAGCGA GCGAGATTAT CCAGCAAGCC CTACTCATTA AAGAGGCCAA TAACCTCCCC 480

ATTGAAAAAG CGCTCAACAT TGTTTTTATG GGAATGGGCG AGCCTTTGAA CAATTTAGAT 540

GAGGTGTGTA AAGCGGTTGA GATTTTTAAT ACCGGCATGC AAATTTCACC TAAAAGGATC 600

ACCATTTCCA CGAGCGGCGT GGCCGATAAA ATCCCCATTT TAGCGGGCAA AAACTTAGGC 660

GTGCAATTAG CCATATCCTT ACACGCCGTA GATGATAAAA CGCGCTCGTC TTTAATGCCC 720

TTGAATAAAA AATACAACAT TGAATGCGTT TTGAATGAAG TGAGGAAATG GCCTTTAGAG 780

CAGCGAAAAA GAGTGATGTT TGAATACCTT TTAATCAAAG ATTTAAACGA TAGCCTGGAT 840

TGCGCTAAAA AACTTTTAAA ACTTTTAAAC GGCATTAAAT CCAAAGTGAA TTTGATCTTA 900

TTCAACCCGC ATGAAGGCTC TAAGTTTGAG CGCCCTAGCT TAGAGAGCGC CAGAATGTTT 960

GCGGATTTTT TAAACGCCAA AGGCTTATTA TGCACCATTA GAGAATCCAA AGCCTTGGAT 1020

ATTGAAGCGG CTTGCGGGCA ATTGAGGGAG AAAAAGCTCC AGCAGAAAAT TTAA 1074

(2) INFORMATION FOR SEQ ID NO: 484:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1407 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1407

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 484:

ATGGCTGAAT GGAAAACGGA CACAGAAGAA GTCAAAAAGG TTGTTGGAAG ATGCAGGGAA 60

TTTAAAAGAT CCCTGCAAGA AGAAAAATGC AGTCCATTTA TCAAAGACCT TGATAGTTAC 120

GCGCTAAAAA TCATAGTGGA GCGCAGAAAA ACTGAAATGC AATTGGAAAA AGCCATAGGA 180

GAATTAAAAA AAGCCAAAAG CAATGAAGAT GACGCTAAAG TTGCTTTAAG AGTCTTGCAA 240

GGTGCTTCTG TCGTCTCGTG GATTTGGCCT CCTGCTAGAA TAGCTGCTAC GGCAGCCATT 300

GTAGCCGCTG AAGCTGTTTT GAAATTTATG AAAGAAGACA CAGAAAAATG CAAAAGGAAT 360

GTGGAGCTAT TAGAACGAAT GCTTGAAATC TACTCGAATC AAGCCAAAGC GAGCGCGAAT 420

CTTATGAATC AAGCTTGGGA GGGCATTAAA AAGAGGTTGC ATTTTTATAC TGATAAGCAC 480

CAGGAATTTA TCAGGCGTTT GAAACAAGCG AGCGATGCGA TAGATAACGA ATACAACTTT 540

CCAACTCCAG GCGTTTTATT GGAATACGAT TTTGAACGGC CTGCTATCTC TTATACCCCT 600 AAAAAAAGCG TTTTTAATGA GCGCTTGAAG GATTTGAGGG AAAATTTTAG CGCTTCTTTA 660

TACGCTGATT TGAAAGACAA GATCCATCAT AACGCCTTGT CTAACGATGA TTTAGAACGC 720

ATGATAGCTT TTAGAGAGCA AGAATTTGAA AAGAGTTTAG AGGATTGGAT GGGTGCATAT 780

TCTTATGATG AAAACCCTAA CGATGAATTA GATCGCATGG CAATATCTAA AGAGCAGGAG 840

TTGGAAAAGA GTTTAGAGGA TTTGATGCCA AGCGTTTTAG GCGTGCCTTC TTATAACGAA 900

AGCTTGACTT TAGCCAAAAA TCGTTGCGTT AAAAACTTTA AGGAAGCTTT AGAAGGTTTT 960

ACAGAAAAAA TCAAAGAATC CCCTAACGAT TCAAACGCTA TCAATGAAGC CTTTGATAAT 1020

TTAGAAACAG AGTTAGAGCG CGCTACAGAA AATTTGAGTC AAAAAATCGA TCCCGTTTTA 1080

GAACGGAATG AAAATTATAC GCAAAAAGCG TTGGAGTATA GGGAGTTTTT AGAAAGCCGT 1140

AAAGAGAGCT TTATTGTAGA TGAAAAAAAC CCCTATCCGG AAGAAGTCAG CTTTAATGAA 1200

TGGCGTTGGG CGGAATTTGA TAGCGTTTTT AGCGCCATTG TGCCTTTAGA AGATTTAAAT 1260

AAAACCGCAT GCGCTCATCA TGCCCTAAAG GCTTTACAAG CTACGCTAAA GACAACGATT 1320

TGGGCTTTGA TGCGACAGAG TTGGAACAGA TCGCAAAAGG ATTCATCCCT AGGGGGTATT 1380

TGTGGCATTT TGACGCGAAT GTTTTAG 1407

(2) INFORMATION FOR SEQ ID NO: 485:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 807 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...807

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 485:

ATGAAACAAA GTTTGCGCGA ACAAAAATTA TTGAAAATTT TGGAAAATGA TGTCTTGACG 60

ATTTTGGATA GTTTTTCTAA TTACCTTTTT GAACTGAGAG AAGAATTGGA CTTCATAGAA 120

GAAGAAATGG AAGGTGAAAT CACTGAACAA AACCTTACCG CTCTTTATGA TTTTTCTAAT 180

TTCTTAGAAG ACCATGTCAA TGTGTTTTAT GAGAATGTTT TGAATATAGA TGATGTCAAA 240

ACAGAACACC TTTATTCAGG TCTCATAGAT AGTCTTAACG CTAATCTTCA CTTTGTCAAG 300

TCATTTCTCA GTAATCAGGA TTTAGACTTC CGCTTTTTTA AAGAAATAAA CGATGGGCAA 360

GATCCCCAAA AAACATTATC AAGATTGATT CCTCTTCAAA GTGGGAAGAA TGATGCAAGC 420

TCGTTTAAAG CCAATAATTC TTTTGTTTCA TTAGTTTATG TTTATGCTTA CTTCATGCTA 480

GAAACTATCA GGCAGTCGTA TAGGATTCTC AGATTACTAG AAAAACCTAT CAATAACAAC 540

ATAAGCGAGG ACATGCAGAG CGATATAGAG AATTTTTTTG TTCAAGCAAA TTTTTTAGAA 600

TACTATGTTC AGAACAAAAT ATACCCAACC AATCATGCCT ATGACTTCAC GCATTTGATC 660

ATGGACTCCA TTATTCCTAA TTGGATTCAG ATTGATATGA GCGTTGAAGC TAAAAAGAAA 720

GAGCTTTTTG AAAAATATTT TCAAAACATT GATGAAGTAA CAAACAAAAT GCTCGATCAA 780

GAAAATCAAA ACAAAAACAG CGATTGA 807

(2) INFORMATION FOR SEQ ID NO: 486:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 777 base pairs (B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...777

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 486:

TTGCTCTCTA ATAAAACGCT CCCTAAAAGA TTCGCCACTT ATAGCTTGCA AGAAGTGGGC 60

GTTATTTTCC TGACCACTCA GATTTTATCT ATCATGCGCA AGACCCGTTG CTCTAAAACG 120

CTTTTTTTTA TCACTAGGGG CAGGGAGAGT TTCCGCTACC AGCTGTGCGA TCATTACAAA 180

CAAAAACGCC ACCAATTTGA TGAAGATTTT AGATCCCTTT TAAAAGCTCT CAAAATCGCT 240

TTAGTGGAAA AATACCCCCT AAAAAAAGGG GCTAAAATCC AGGGCGAACA TTGTTTTGAA 300

TATGAAGCCG ATGATATTAT CTCTTTTTAC AAAAAGAAAG ACCCCAACAA TTATGTGATA 360

GCGAGCATGG ATAAGGATAT TTTGTATTCC AATAGAGGCT CTCATTTCAA TCTCAAAACG 420

AACGCTTTTT TTAATGTGAG CCAAAAAGAA GCCCATTTTT TTGCTTATTA CCAATGCGTT 480

GTGGGGGATA AAGGGGATAA TATTAAGGGG GTTAAAGGGA TTGGCGGCTT CAACTATAAA 540

GATTTTTTAA ACGAAGACGC TAAAGAGCAT GAACTATGGG AGCAGATCAT TCAAGCGTTC 600

AAAATTAAAG AAGATTTGAG CGATAGCGAA GCCAAAGAAA AGGCTCTATT AAACATGCGT 660

TTAGTCAATA TGCACCAGAT GACCCACCAT GGCGTGATCA AACTATGGGA GCCTGAGTTT 720

AAAAAAGCTT TTTTCCCTAA AAAACCCCAA AGACCTGATT TTAAAAGAAT TTCTTAA 777

(2) INFORMATION FOR SEQ ID NO: 487:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 771 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...771

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 487: TTGTGTTTGA AACTCTTAAT TTGGAATTTT AAGGAGCATT CTTTGAAAGT CAATTTCTTT 60 GCCACTTGTC TAGGAGCAGC TATTTATAGC AACGCATCGC TTAACGCTAT CAAATTACTC 120

CGCAAGGAAA ATTTGGAAGT GGTTTTTAAA AAAGACCAGA CATGTTGTGG CCAGCCAAGC 180

TACAACTCAG GATACTATGA AGAGACTAAA AAAGTCGTTT TATACAATAT CAAACTTTAT 240

TCCAATAACG ACTACCCTAT TATTTTGCCT AGCGGTTCAT GCACAGGGAT GATGCGGCAT 300

GATTATTTGG AATTGTTTGA AGGGCATGCG GAATTTAACA TGGTTAAAGA TTTTTGCTCT 360

AGGGTGTATG AATTGAGCGA GTTTTTGGAT AAAAAATTGC AAGTCAAATA CGAAGATAAG 420

GGCGAACCTC TCAAAATCAC ATGGCATTCT AATTGCCATG CCTTAAGGGT GGCTAAAGTG 480

ATTGACTCGG CGAAAAATCT CATCAGACAG CTTAAAAATG TGGAACTCAT TGAATTGGAA 540

AAAGAAGAAG AATGCTGCGG GTTTGGGGGG ACTTTTTCAG TTAAAGAGCC TGAAATTTCA 600

GCGGTTATGG TCAAAGAAAA GATTAAAGAC ATAGAGAGCC GTCATGTGGA TGTGATCGTT 660

TCAGCGGATG CTGGGTGCTT GATGAATATC AGCACCGCTA TGCAAAAAAT GGGCTCTTTG 720

ACAAAACCCA TGCATTTTTA TGACTTTTTA GCCTCAAGGC TTGGACTTTA A 771

(2) INFORMATION FOR SEQ ID NO: 488:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1410 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1410

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 488:

TTGAAAATAT TCGTTCTGTT GATGTCGGTA ATTTTAGGAA TATCATTAAC AGGTTGCATA 60

GGCTATCGTA TGGACTTAGA ACATTTTAAC ACGCTCTATT ATGAAGAAAG CCCTAAAAAA 120

GCTTATGAAT ATTCCAAACA ATTCACGAAG AAAAAAAAGA ACGCTCTTTT ATGGGACTTG 180

CAAAACGGCT TGAGCGCTTT ATACGCAAGG GATTATAAGA CTTCTTTAGG GGTATTGGAT 240

CAAGCCGAGC AACGCTTTGA TAAAACCCAA AGCGCTTTCA CAAGAGGGGC TGGTTATGTG 300

GGCGCTACCA TGATTAATGA TAATGTACGC GCTTATGGGG GGAATATTTA TGAGGGCGTT 360

TTAATCAATT ATTACAAAGC GATAGACTAC ATGCTTTTAA ACGATAGCGC GAAAGCTAGG 420

GTGCAATTCA ACCGCGCGAA TGAACGCCAA CGCAGGGCTA AAGAATTTTA TTATGAGGAA 480

GTGCAAAAAG CCATTAAAGA AATCGATTCT AGCAAAAAGC ACAATATTAA TATGGAACGC 540

TCTAGGGCAG AAGTGAGCGA GATTTTAAAC AACACCTATT CTAATTTAGA CAAATACGAA 600

GCTTATCAAG GCTTGCTTAA CCCGGCGGTT TCGTATCTTT CAGGGTTGTT TTACGCTTTA 660

AATGGGGATA AGAATAAGGG ATTAGGCTAT CTTAATGAAG CCTATGGGAT CAGTCAAAGC 720

CCTTTCGTGG CTCAAGACTT GGTTTTTTTC AAAAACCCTA ACAGGAGCCA TTTCACTTGG 780

ATCATCATTG AAGATGGTAA AGAGCCGCAA AAAAGCGAAT TTAAAATTGA TGTGCCTATT 840

TTTATGATTG ATTCGGTTTA TAACGTGAGC GTGGCCTTGC CCAAGCTAGA AAAAGGGGAA 900

GCGTTTTATC AAAATTTCAC CCTCAAGGAC GGAGAAAAAG TAACACCCTT TGACACTTTA 960

GCCTCAATAG ATGCGGTGGT CGCTAGCGAA TTCAGGAAGC AATTGCCCTA CATTATCACT 1020

AGGGCTATTT TATCGGCCAC TTTTAAAGTG GGCATGCAAG CGGTGGCGAA CTATTATTTA 1080

GGGTTTGTTG GCGGGTTAGT AACTTCGTTG TATTCAGGTG TGAGCACCTT TGCAGACACC 1140

AGAAACACGA GCATTTTTGC CCATAAAATC TACCTCATGC GCATCAAAAA CAAAGCCTTT 1200

GAAAGTTATG AAGTTCGAGC CGATTCCATT GACGCTTTTT CGTTTTCATT AAAGCCTTGT 1260 AAAAGATCGC TTGAAAGCCC TAAAATCATT GACGCTAGGG AATTGCTTTC AGGGTTTGTA 1320 ACAGCCCCAC AAGTCTTTTG CTCTAACCGC CATAATATTT TATATGTGCG CAGCTTTAAA 1380 AACGGGTTTG TTTTGAGTCA TTTAAAATGA 1410

(2) INFORMATION FOR SEQ ID NO: 489:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1053 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...1053

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 489:

ATGAAACAAA TAAAAGCTTT AGCCTTATTT AGTGGGGGGT TGGATAGTTT GTTGTCCATG 60

AAATTACTCA TTGATCAAGG CATTGAAGTA ACCGCTTTAC ACTTCAATAT AGGGTTTGGA 120

GGGAATAAAG ATAAAAGAGA GTATTTTGAA AACGCCACCG CGCAAATTGG GGCTAAACTC 180

TTGGTGTGCG ATATTAGAGA GCAGTTCTTT AACGATGTGT TGTTCAAGCC CAAATACGGC 240

TATGGGAAGT ATTTCAACCC TTGCATTGAT TGCCATGCCA ACATGTTTAG GAACGCTTTT 300

TATAAAATGC TTGAATTGGA TGCGGATTTT GTTTTGAGCG GGGAAGTGCT AGGGCAACGC 360

CCTAAATCCC AAAGGAAAGA AGCGCTCAAT CAGGTGAGGA AATTAGTCAG AGAAGTGGGC 420

GAAGAGGCTC GTTTTGATCT TATTTTAGAC CGAACGCAAG CAAGCGGTGA AAAACCGCAA 480

TTTTTAGACG AATTGCTCTT AAGGCCCATG AGCGCTAAAC TCTTAGAGCC TACTTTTATG 540

GAAAAAAAGG GTTGGGTTGA TAGGGAAAAG CTTTTAGATG TGAGTGGTAG GGGGCGTGCT 600

AGGCAATTGC AAATGATCAA AGATTATGGC TTGAAATATT ATGAAAAGCC AGGTGGGGGG 660

TGCTTGCTTA CGGACATTCA AGTGAGTAAT AAGATTAAGA ATTTGAAAGA ATACAGAGAA 720

ATGGTGTTTG AAGATGGCGT GATTGTCAAA AACGGGCGTT ATTTTGTCCT ACCCCATAAC 780

GCTCGTTTGG TGGTGGCAAG GAATGAAGAA GAAAACCATA AATTAGACAT TGAACACCCC 840

TTAATGGATA AGATTGAATT GCTAGGCTGT AAAGGTCCTT TGAGTTTGGT GGATAAAAAC 900

GCCAGCCAAG AAGATAAAGA ATTGGCCGGT CGTATCGCTT TAGGCTATGC TAAGACTTTA 960

AAAAATCAAG CTTACCTCAT TCAAATAGGG AATGAAAAGC GCGAACTTTA CCCTTTGGAT 1020

AAAGAGAACG CTAGGGAGTA TTTGTTCGCT TGA 1053

(2) INFORMATION FOR SEQ ID NO: 490:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1218 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE. NO

(vi) ORIGINAL SOURCE

(A) ORGANISM. Helicobacter pylori

(ix) FEATURE

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1. .1218

(xi) SEQUENCE DESCRIPTION- SEQ ID NO: 490:

ATGAAAAAAT ACAGCGCTAT CCCCACCCCT TGCTATGCGC TAGAGAGCGA ACGCTTAGAA 60

AAAAACGCCA AGATTTTAGA AATCGTGCGC CAGCAAAGCG GGGCAAAGGT TTTGCTCGCT 120

TTAAAAGGGT ATGCGTTTTG GCGTGAGTTT GGGATTTTGA GGCAAAAATT GAACGGGTGT 180

TGCGCGAGCG GTCTTTATGA GGCTAAGCTC GCTTTTGAAG AATTTGGGGG GCGAGAGAGC 240

CATAAGGAAA TTTGCGTTTA TAGCCCGGCC TTTAAAGAGG CTGAAATGAG CGCGATTTTA 300

CCCCTAGCGA CAAGCATCAT TTTCAACTCT TTTCACCAAT ACGCCACCTA CAAAGACAGG 360

ATTTTAGACA AAAACAAGCA GTTAGAAAAC TTGGGCTTAA GCCCCATTAA AATGGGTTTG 420

AGGATTAACC CCCTTTATAG CGAAGTAACC CCAGCGATCT ATAACCCATG CTCTAAAATG 480

AGCCGGTTAG GGATTACGCC TAGCGGATTT GAAAAAGGAG TCAAAGAGCA TGGCTTAGAG 540

GGGGTGAGCG GGTTGCATTT CCATACGCAT TGCGAGCAAA ACGCCGACGC TTTGTGCCGG 600

ACTTTAGAGC ATGTGGAAAG GCATTTCAAG CCTTATTTAG AAAACATGGC GTGGGTGAAT 660

TTTGGTGGGG GGCATCATAT CACCAGGAGC GATTATGATG TGAATTTGCT CATTCAAACG 720

ATTAAGGATT TTAAAGAACG CTACCACAAT ACAGAAGTGA TCTTAGAGCC TGGGGAAGCC 780

ATAGGGTGGC AATGCGGGTT TTTAATCGCA AGCGTGATAG ATATCGTTCA AAACGATCAA 840

GAAATTGCGA TTTTAGACGC TTCTTTTAGC GCTCACATGC CCGATTGCCT AGAAATGCCT 900

TATCGCCCTA GTATTCTTAA GGTTTCTGTA GAAAACGATG AGGAAATTAT TGAAGTTGAA 960

AAGGGCGAAA ATCAAGGGGC GTTTTCTTAC TTTTTAGGCG GCCCCACTTG TTTGGCGGGG 1020

GATTTTATGG GGAGTTTTAG CTTTGAAACG CCTTTAAAAA GGGGCGATAA AATCGTGTTT 1080

CAAGACATGC TCCATTATAC GATCGTGAAA AACAACTCGT TTAATGGCGT GCCACTGCCA 1140

AGCCTGGCTA AAATAGATTC GCAAGGTTTT AAGATCCTCA AAAGCTTTTC TTATGAAGAT 1200

TATAAAAACA GGAATTAA 1218

(2) INFORMATION FOR SEQ ID NO: 491:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 966 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ll) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi ) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY- mιsc_feature

(B) LOCATION 1...966

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 491. ATGGCTGATA GTTTAGCGGG CATTGATCAA GTTACGAGTT TACATAAAAA TAACGAGTTG 60

CAATTGTTGT GTTTCAGGCT GGGTAAAAAC AAGGATTTGT ATGCGGTCAA TGTCTTTAAG 120

ATCCGTGAAG TGGTGAAATA CCATGGCAAT CTCACTATCA TTAGCCACGA AAACAATTCG 180

CTCGTTGAGG GCTTGATCAT TATAAGAGAG CTCACCATTC CTTTGATTGA CATGAAAAAA 240

TGGTTTTATT ATGACAGCCA AAACAAGAGC AAGGATTTAC GCCCTTACAG GATAGAAAAA 300

GAAAAAGGCG AAGACGATAT TGTCATGATT TGTGAGTTTT CTCGCTGGAC CATAGGGGTT 360

AGGATCTATG AAGCGGATAG GATTTTGAGC AAGAAATGGA CTGAAATGGA GCAAAGCGCT 420

GGGCTAGGGG GATCTGCTGG GAATAACAAA CTCGTGAGCC GCACGCGCTA TTTTGACGGG 480

CGCTTGGTGC AAGTGGTGGA TATTGAAAAA ATGCTTATAG ACGTGTTCCC TTGGATTGAA 540

GATGAAAAAC ACAACGATTT AGAGACGCTT TCTAAAATCC ATTCTAACCA ATGCGTTTTG 600

CTCGCTGATG ATTCCCCAAG CGTCTTAAAA ACCATGCAAA TGATTTTAGA CAAGCTGGGC 660

GTCAAGCACA TTGACTTTAT CAATGGTAAA ACCTTATTAG AGCATTTGTT CAACCCAACA 720

ACCGATGTGA GTAATATTGG CCTGATTATT ACCGATTTAG AAATGCCAGA AGCGAGCGGT 780

TTTGAAGTGA TCAAACAGGT TAAAAACAAT CCTTTGACTT CAAAAATCCC CATTGTGGTC 840

AATTCTTCTA TGAGCGGCAG CTCTAATGAA GACATGGCCA GGAGTTTGAA GGCCGATGAT 900

TTCATCTCCA AGTCTAACCC TAAAGACATC CAGCGGGTGG TTAAGCAATT TTTGGAATTA 960

GCATGA 966

(2) INFORMATION FOR SEQ ID NO: 492:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 96 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...96

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:492:

Glu Arg lie Lys Arg Arg Ala Val Met Lys Lys lie Val Val Ser Leu

1 5 10 15

Cys Val Ala Leu Gly Phe Leu Ser Ala Asp Pro Ala Gin Ala Asn Lys

20 25 30

Ala lie Ser Asp Ala Asp Leu lie Glu Glu lie Arg Asp Leu Lys Lys

35 40 45 lie lie Ser Ala Gin Asn Thr Glu lie Asn Gin Leu Arg Lys Val Gin

50 55 60

Glu Val Leu Ser Gly Gin Leu Gly Asp Met Arg Lys Asp lie Leu Ser 65 70 75 80

Thr Arg Asp Tyr Cys lie Ser Leu Arg Pro Tyr lie Tyr Asn Trp Arg 85 90 95

(2) INFORMATION FOR SEQ ID NO: 493:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 301 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear (11) MOLECULE TYPE: protein

(ill) HYPOTHETICAL : YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...301

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 493:

Asn Ala Trp Asn Asp Phe Val Lys Ser Gly Ser Leu Gly Pro Phe Ser

1 5 10 15

Asn Gly Tyr Tyr Glu His Lys Thr lie Arg Leu Asn Pro Glu Gin Asn

20 25 30

Leu lie Val Leu Ser His Tyr Leu Lys Leu Leu Glu lie Gin Arg Glu

35 40 45

Ala Ala Lys Met Thr Ala lie Phe Gly Ala Lys Gin Pro His Pro Gin

50 55 60

Ser Leu Thr Val Gly Gly Val Thr Ser Val Met Asp lie Leu Asp Pro 65 70 75 80

Thr Arg Leu Ala Glu Trp Lys Ser Lys Phe Glu Val Val Ala Asn Phe

85 90 95 lie Asn His Ala Tyr Tyr Pro Asp Leu Val Met Ala Gly Glu Met Phe

100 105 110

Ala Asn Glu Pro Ser Val lie Lys Gly Cys Gly Leu Arg Asn Phe lie

115 120 125

Ala Tyr Glu Glu Val Leu Leu Gly Lys Asp Lys Tyr Leu Leu Ser Ser

130 135 140

Gly Val Val Leu Asp Gly Asp lie Ser Lys Leu His Pro lie Asp Glu 145 150 155 160

Ser Leu lie Lys Glu Glu Val Thr His Ser Trp Tyr Gin Tyr Glu Asp

165 170 175

Thr Lys Glu Val Gin Leu His Pro Tyr Asp Gly Gin Thr Asn Pro His

180 185 190

Tyr Thr Gly Leu Lys Asp Gly Glu Ser Val Gly lie Glu Asn Lys lie

195 200 205 lie Pro Ala Lys Val Leu Asp Thr Lys Asp Lys Tyr Ser Trp lie Lys

210 215 220

Ser Pro Arg Tyr Asp Ser Lys Pro Met Glu Val Gly Pro Leu Ser Ser 225 230 235 240

Val Val Val Gly Leu Ala Ala Lys Asn Pro Tyr Val Thr Glu Val Ala

245 250 255

Thr Lys Phe Leu Lys Asp Thr Lys Leu Pro Leu Glu Ala Leu Phe Ser

260 265 270

Thr Leu Gly Arg Thr Ala Ala Arg Cys lie Glu Ala Lys Thr lie Ala

275 280 285

Asp Asn Gly Leu Leu Ala Phe Asp Ala Leu Val Glu lie 290 295 300

(2) INFORMATION FOR SEQ ID NO: 494:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 169 ammo acids (B) TYPE: amino acid (D) TOPOLOGY: linear

(11) MOLECULE TYPE protein

(m) HYPOTHETICAL- YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM- Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...169

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 494:

Gly lie Asn Met Ser Lys Lys lie Val Val Asp Pro lie Thr Arg lie

1 5 10 15

Glu Gly His Leu Arg lie Glu Val lie Val Asp Asp Asp Asn Val lie

20 25 30

Thr Asp Ala Phe Ser Ser Ser Thr Leu Phe Arg Gly Leu Glu Thr lie

35 40 45 lie Lys Gly Arg Asp Pro Arg Asp Ala Gly Phe lie Ala Gin Arg lie

50 55 60

Cys Gly Val Cys Thr Tyr Ser His Tyr Lys Ala Gly Val Thr Ala Val 65 70 75 80

Glu Asn Ala Leu Gly lie Thr Pro Pro Leu Asn Ala Gin Leu Val Arg

85 90 95

Ser Leu Met Asn Met Ala Leu Leu Phe His Asp His Val Val His Phe

100 105 110

Tyr Thr Leu His Gly Leu Asp Trp Cys Asp lie Leu Ser Thr Leu Lys

115 120 125

Ala Asp Pro lie Gin Ala Ala Lys Leu Ser Phe Lys Tyr Ser Pro Tyr

130 135 140

Pro lie Asn Thr Gly Ala Gly Arg lie Lys Ser Gly Ser Lys Thr Leu 145 150 155 160

Gly Met lie Ser Leu Lys Ala Asp Leu 165

(2) INFORMATION FOR SEQ ID NO: 495:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 185 ammo acids

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(ill) HYPOTHETICAL : YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...185 (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 495:

Trp Leu Trp Leu His Gin Arg Met Ser Gin Lys lie Leu lie Leu Gly

1 5 10 15 lie Gly Asn lie Leu Phe Gly Asp Glu Gly lie Gly Val His Leu Ala

20 25 30

His Tyr Leu Lys Arg Asn Phe Ser Phe Phe Pro Ser Val Asp lie Val

35 40 45

Asp Gly Gly Thr Met Ala Gin Gin Leu lie Pro Leu lie Thr Ser Tyr

50 55 60

Glu Lys Val Leu lie Leu Asp Cys Val Ser Ala Lys Gly Val Glu lie 65 70 75 80

Gly Ser Val Tyr Ala Phe Asp Phe Lys Asp Ala Pro Lys Glu lie Thr

85 90 95

Trp Ala Gly Ser Ala His Glu Val Glu Met Leu His Thr Leu Arg Leu

100 105 110

Thr Glu Phe Leu Gly Asp Leu Pro Lys Thr Phe lie Val Gly Leu Val

115 120 125

Pro Phe Val lie Gly Ser Glu Thr Thr Phe Lys Leu Ser Ser Glu Met

130 135 140

Leu Asn Ala Leu Glu Thr Ala Leu Lys Ala lie Glu Thr Gin Leu Asn 145 150 155 160

Ala Trp Gly Val Lys Met Gin Arg Thr Asp His lie Ala Leu Asp Cys

165 170 175 lie Ala Glu Leu Ser Tyr Lys Gly Phe 180 185

(2) INFORMATION FOR SEQ ID NO: 496:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 108 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...108

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:496:

Tyr Gin lie Leu Asn Gin Arg Lys Thr Met Lys Lys Val Leu Leu Leu

1 5 10 15

Thr Leu Ser Leu Ser Leu Ser Phe Trp Leu His Ala Glu Arg Asn Gly

20 25 30

Phe Tyr Leu Gly Leu Asn Phe Ala Glu Gly Ser Tyr lie Gin Gly Gin

35 40 45

Gly Ser lie Gly Glu Lys Ala Ser Ala Glu Asn Ala Leu Asn Gin Ala

50 55 60 lie Asn Asn Ala Gin Asn Ser Leu Phe Pro Asn Thr Gin Ala lie Arg 65 70 75 80 sp Val Gin Asn Ala Leu Asn Ala Val Lys Asp Ser Asn Lys lie Ala

85 90 95 sn Arg Phe Ala Gly Asn Gly Gly Ser Gly Gly lie 100 105

(2) INFORMATION FOR SEQ ID NO: 497:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 128 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...128

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 497:

Arg Val Ser Gly Asn Leu Lys Ser Asp Gin Ser Thr Cys Ala Pro Tyr

1 5 10 15

His lie Asp Lys Asn Gin Glu Tyr Lys Gly Arg Tyr lie Gly Gin Val

20 25 30

Pro Arg Gly Met Leu Ser His Trp Val Arg lie Lys Asn Gly Val Val

35 40 45

Glu Asn Tyr Gin Ala Val Val Pro Ser Thr Trp Asn Ala Gly Pro Arg

50 55 60

Asp Ser Lys Asn Gin Arg Gly Ala Tyr Glu Met Ser Leu lie Gly Thr 65 70 75 80

Lys lie Ala Asp Leu Thr Gin Pro Leu Glu lie lie Arg Thr lie His

85 90 95

Ser Phe Asp Pro Cys lie Ala Cys Ser Val His Val Met Asp Phe Lys

100 105 110

Gly Gin Ser Leu Asn Glu Phe Lys Val Glu Pro Asn Phe Ala Lys Phe 115 120 125

(2) INFORMATION FOR SEQ ID NO: 498:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 86 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE: (A) NAME/KEY: misc_feature

(B) LOCATION 1...86

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 498:

Leu Tyr Gin Asn Asp Lys Gly Phe Lys Thr Glu Leu Arg lie Leu Ser

1 5 10 15

Val Phe He Val Glu Phe Leu Val Asn He Leu Gly Phe Met Leu Ala

20 25 30

His Met Leu His Phe Trp Phe Leu Arg Cys Val Lys Ala Leu Ala Trp

35 40 45

Leu Met Lys Thr Phe Asp Arg Arg Arg Tyr Phe Asp Ala Lys Ala Asn

50 55 60

Leu Asp Phe Val Phe Gly Asp Ser Lys Ser Glu Glu Glu Lys Lys Arg 65 70 75 80

He He Lys Lys Gly Val 85

(2) INFORMATION FOR SEQ ID NO: 499:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 67 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...67

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 499 :

Tyr Lys Lys Gly Asn Gin He Met Asn He Gin Thr Lys Lys Arg Phe

1 5 10 15

Leu Ala Asn Leu Leu Leu Phe Ser Leu Phe Ser Cys Leu Lys Ala Glu

20 25 30

Thr Leu Ser Glu Asp His Gin He Leu Leu Ser Ser Asp Ala Phe His

35 40 45

Arg Gly Asp Phe Ala Thr Ala Gin Lys Gly Tyr Met Asn Leu Tyr Arg

50 55 60

Ala Asn Gin 65

(2) INFORMATION FOR SEQ ID NO: 500:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 256 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein (m) HYPOTHETICAL- YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE.

(A) NAME/KEY. mιsc_feature

(B) LOCATION 1...256

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 500 :

Leu Cys Leu Lys Leu Leu He Trp Asn Phe Lys Glu His Ser Leu Lys

1 5 10 15

Val Asn Phe Phe Ala Thr Cys Leu Gly Ala Ala He Tyr Ser Asn Ala

20 25 30

Ser Leu Asn Ala He Lys Leu Leu Arg Lys Glu Asn Leu Glu Val Val

35 40 45

Phe Lys Lys Asp Gin Thr Cys Cys Gly Gin Pro Ser Tyr Asn Ser Gly

50 55 60

Tyr Tyr Glu Glu Thr Lys Lys Val Val Leu Tyr Asn He Lys Leu Tyr 65 70 75 80

Ser Asn Asn Asp Tyr Pro He He Leu Pro Ser Gly Ser Cys Thr Gly

85 90 95

Met Met Arg His Asp Tyr Leu Glu Leu Phe Glu Gly His Ala Glu Phe

100 105 110

Asn Met Val Lys Asp Phe Cys Ser Arg Val Tyr Glu Leu Ser Glu Phe

115 120 125

Leu Asp Lys Lys Leu Gin Val Lys Tyr Glu Asp Lys Gly Glu Pro Leu

130 135 140

Lys He Thr Trp His Ser Asn Cys His Ala Leu Arg Val Ala Lys Val 145 150 155 160

He Asp Ser Ala Lys Asn Leu He Arg Gin Leu Lys Asn Val Glu Leu

165 170 175

He Glu Leu Glu Lys Glu Glu Glu Cys Cys Gly Phe Gly Gly Thr Phe

180 185 190

Ser Val Lys Glu Pro Glu He Ser Ala Val Met Val Lys Glu Lys He

195 200 205

Lys Asp He Glu Ser Arg His Val Asp Val He Val Ser Ala Asp Ala

210 215 220

Gly Cys Leu Met Asn He Ser Thr Ala Met Gin Lys Met Gly Ser Leu 225 230 235 240

Thr Lys Pro Met His Phe Tyr Asp Phe Leu Ala Ser Arg Leu Gly Leu 245 250 255

(2) INFORMATION FOR SEQ ID NO: 501:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 255 ammo acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE: (A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...255

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 501 :

Met Lys Lys He Phe Leu Gly Met Ala Leu Ala Phe Ser Val Ser Met

1 5 10 15

Ala Glu Lys Ser Gly Ala Phe Leu Gly Gly Gly Phe Gin Tyr Ser Asn

20 25 30

Leu Glu Asn Gin Asn Thr Thr Arg Thr Pro Ser Ala Asn Asn Asn Thr

35 40 45

Pro He Asn Thr Ser Met Phe Gly Asn Asn Gin Ala Ala Pro Ala Gin

50 55 60

Glu Thr Pro Ser Val He Asn Thr Asn Asn Tyr Gly Gin Met Tyr Gly 65 70 75 80

Val Asp Ala Met Ala Gly Tyr Lys Trp Phe Phe Gly Lys Thr Lys Arg

85 90 95

Phe Gly Phe Arg Thr Tyr Gly Tyr Tyr Ser Tyr Asn His Ala Asn Leu

100 105 110

Ser Phe Val Gly Ser Lys Leu Gly He Met Asp Gly Ala Ser Gin Val

115 120 125

Asn Asn Phe Thr Tyr Gly Val Gly Phe Asp Ala Leu Tyr Asn Phe Tyr

130 135 140

Glu Ser Lys Glu Gly Tyr Asn Thr Ala Gly Leu Phe Val Gly Phe Gly 145 150 155 160

Leu Gly Gly Asp Ser Phe He Val Gin Gly Glu Ser Tyr Leu Lys Ser

165 170 175

Gin Met Gin He Cys Asn Asn Thr Ala Gly Cys Ser Ala Ser Met Asn

180 185 190

Thr Ser Tyr Phe Gin Met Pro Val Glu Phe Gly Phe Arg Ser Asn Phe

195 200 205

Ser Lys His Ser Gly He Glu Val Gly Phe Lys Leu Pro Leu Phe Thr

210 215 220

Asn Gin Phe Tyr Lys Glu Arg Gly Val Asp Gly Ser Val Asp Val Phe 225 230 235 240

Tyr Lys Arg Asn Phe Ser He Tyr Phe Asn Tyr Met He Asn Leu 245 250 255

(2) INFORMATION FOR SEQ ID NO: 502:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 218 amino acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(m) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature ( B ) LOCATION 1 . . . 218

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 502 :

Ala Cys Glu He Arg Ala Trp Ala Phe Asp Arg Met Leu Arg Val Leu

1 5 10 15

Ser Val Gly Val Val Phe He Leu Leu Gly Cys Gin Phe Phe Asn Lys

20 25 30

Thr Thr Leu His Leu Lys Tyr Lys Asp Tyr Pro Lys Asn Ser Pro Leu

35 40 45

Lys Thr Ala Ser Thr Leu Thr Pro Pro Lys He Phe Phe Asn Ala His

50 55 60

Phe Val Pro Pro Phe Tyr Gin Lys Glu Phe Lys Lys Ala Leu Ala Gin 65 70 75 80

Gin He Ala Tyr Phe Leu Lys Asp Lys Ser Ala Leu Thr Phe Asn He

85 90 95

Ser Gly Asn Val Phe Phe Ser Phe Glu Glu Ser Pro Lys Asp Leu Lys

100 105 110

Ala He Lys Glu Arg Leu Lys Lys Thr He Glu Pro Asn Thr Asp Pro

115 120 125

Lys Ala Val Met Arg Phe Leu Asn Leu Gin Ala Ser Leu He Leu Glu

130 135 140

Cys Val Pro Gin Thr Ala Cys Pro Phe Asp Thr Leu Leu He Pro Thr 145 150 155 160

Ala Leu Ser Val Pro He Asp Tyr Ala Asn Arg Leu Gly Asp Asn Pro

165 170 175

Ser Leu Phe Pro Gin Glu Asp Lys Ser Tyr His Asn Ala Leu He Lys

180 185 190

Ala Leu Asn Lys Ala Tyr Tyr Ser Leu Met Glu Gly Leu Glu Lys Arg

195 200 205

Leu Asn Ala He Glu Asn Ala Ala Trp Leu 210 215

(2) INFORMATION FOR SEQ ID NO: 503:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 124 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...124

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 503:

Thr He Gin Glu Arg Leu Tyr Arg His Glu He Ser Arg Leu Gin Val

1 5 10 15

Lys Thr Asp Glu Thr Leu Lys Leu He Lys Glu Ala Lys Lys Arg Leu 20 25 30 Asn Tyr Asn Asp Asp He Arg Asp Val Leu Gin Gly Leu Leu Asn He

35 40 45

Val Pro Asp Leu He Thr He Asn Ser He Glu He Asp Gin Gin Ser

50 55 60

Val Val Val Ser Gly Lys Thr Pro Ser Lys Glu Ala Phe Tyr Phe Leu 65 70 75 80

Phe Gin Asn Lys Leu Asn Pro Met Phe Asp Tyr Ser Arg Ala Glu Phe

85 90 95

Phe Pro Leu Ser Asp Gly Trp Phe Asn Phe Val Ser Thr Asn Phe Ser

100 105 110

Asn Ser Leu Leu He Lys Asn Pro Glu Ser He Lys 115 120

(2) INFORMATION FOR SEQ ID NO: 504:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 378 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...378

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 504 :

He Ser He Glu Gin Thr Asn Lys Val Val Tyr Ala Lys Glu Ala Ala

1 5 10 15

He Ser Ala Ala Ser Leu Gly Asp He Lys Thr Ala Met His Leu Ala

20 25 30

Met Leu Tyr Gin Lys He Thr Asn Asn Arg Asn Asp Val Ser He Asn

35 40 45

Lys He Leu Val Asp Gly Tyr Ala Gin Met Gly Gin He Asp Lys Ala

50 55 60

He Glu Leu Leu His Lys He Arg Lys Glu Glu Lys Thr He Ala Thr 65 70 75 80

Asp Asn Val Leu Gly Thr Leu Tyr Leu Thr Gin Lys Arg Leu Asp Lys

85 90 95

Ala Phe Pro Leu Leu Asn Lys Phe Tyr Asn Gin Val His Asp Glu Asp

100 105 110

Ser Leu Glu Lys Leu He Thr He Tyr Phe Leu Gin Asn Arg Lys Lys

115 120 125

Glu Gly Leu Val Leu Leu Gin Ser His He Asp Arg Tyr Gly Cys Ser

130 135 140

Glu Gin Leu Cys Gin Lys Ala Leu Asn Thr Phe Thr Gin Phe Asn Glu 145 150 155 160

Leu Asp Leu Ala Lys Thr Thr Phe Ala Arg Leu Tyr Glu Lys Asn Pro

165 170 175

He Val Gin Asn Ala Gin Phe Tyr He Gly Val Leu He Leu Leu Lys 180 185 190 Glu Phe Asp Lys Ala Gin Gin He Ala Glu Leu Phe Pro Phe Asp Arg

195 200 205

Arg Leu Leu Leu Asp Leu Tyr Thr Ala Gin Lys Lys Phe Asp Gin Ala

210 215 220

Ser Lys Gin Ala Ser Leu He Tyr Gin Glu Arg Lys Asp Pro Lys Phe 225 230 235 240

Leu Gly Leu Glu Ala He Tyr His Tyr Glu Ser Leu Ser Ala Asn Lys

245 250 255

Lys Lys Leu Thr Lys Glu Glu Met Leu Pro He He Gin Lys Leu Glu

260 265 270

Gin Ala Thr Lys Glu Arg Gin Ala Trp Leu Ala Lys Thr Lys Asp Lys

275 280 285

Glu Asp Ala Gin Asp Ala Phe Phe Tyr Asn Phe Leu Gly Tyr Ser Leu

290 295 300

He Asp Tyr Asp Met Asp Val Lys Arg Gly Met Asp Leu Val Arg Lys 305 310 315 320

Ala Leu Ala Leu Asp Ser Asn Ser Val Leu Tyr Leu Asp Ser Leu Ala

325 330 335

Trp Gly Tyr Tyr Lys Leu Gly Asn Cys Leu Glu Ala Lys Lys He Phe

340 345 350

Ser Ser He Ala Lys Glu Leu He Gin Asn Glu Pro Glu Leu Lys Glu

355 360 365

His Asn Lys He He Gin Glu Cys Lys Lys 370 375

(2) INFORMATION FOR SEQ ID NO: 505:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 156 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...156

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 505 :

Phe Tyr Thr Gly Lys Lys Gly Ala Cys Met Arg Lys He Leu Leu Met

1 5 10 15

Gly Leu He Leu Gin Ala Leu Phe Gly Glu Glu Thr Ala Gin Glu Leu

20 25 30

Leu Gin Cys Ser Ala He Phe Glu Ser Lys Lys Ala Glu Leu Lys Glu

35 40 45

Asp Leu Arg Gin Leu Ser Glu Lys Glu Gin Ser Leu Arg He Leu Gin

50 55 60

Thr Glu Asn Ala Arg Leu Leu Asp Glu Lys Ser Asp Leu Leu Asn Lys 65 70 75 80

Lys Glu Lys Glu He Asp Glu Lys Leu Lys Asn Leu Ala Ala Lys Glu 85 90 95 Glu Ala Phe Lys Thr Leu Gin Thr Glu Glu Lys Lys Arg Leu Lys Asn

100 105 110

Leu He Glu Glu Asn Glu Gly He Leu Arg Glu He Lys Gin Ala Lys

115 120 125

Asp Ser Lys He Gly Glu Thr Tyr Ser Lys Met Lys Asp Ser Lys Ser

130 135 140

Ala Leu He Leu Glu Asn Leu Pro Thr Gin Asn Ala 145 150 155

(2) INFORMATION FOR SEQ ID NO: 506:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 141 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...141

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 506:

Lys Arg Leu Cys Asp Arg Leu Trp Ser Gly Gly Tyr Tyr Leu Ser Val

1 5 10 15

Glu Arg Arg Asn Val Met Gly Val Ala Val Val Leu Phe Leu Thr Leu

20 25 30

He Leu Leu Phe Leu Val Leu Arg Asp Phe Gly Leu Ala Ser Pro Lys

35 40 45

Gin Lys He Leu Ala Phe Leu He Val Gly He He Gly Ala Ser He

50 55 60

Ser Val Tyr Thr Tyr Lys Gin Asn Gin Gin Asn Gin Gin Glu He Ala 65 70 75 80

Leu Gin Arg Ala Phe Leu Arg Gly Glu Thr Leu Leu Cys Lys Gly He

85 90 95

Lys Vad Asn Asn Gin Thr Phe Asn Leu Val Ser Gly Thr Leu Ser Phe

100 105 110

Leu Gly Lys Lys Gin Thr Pro Met Lys Asp Val Leu Val Asp Leu Asp

115 120 125

Ser Cys Gin Thr Leu Gin Lys Asp Pro Leu He Gin Pro 130 135 140

(2) INFORMATION FOR SEQ ID NO: 507:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 100 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein (ill) HYPOTHETICAL- YES

(vi) ORIGINAL SOURCE.

(A) ORGANISM Helicobacter pylori

(ix) FEATURE.

(A) NAME/KEY- mιsc_feature

(B) LOCATION 1...100

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 507 :

Ala Lys Asn Thr He Phe Asn Asn Ala Asn Phe Asn Asn Ser Thr Ser

1 5 10 15

Phe Asn Phe Asn Asn Ser Ser Ala Thr Thr Ser Phe Val Gly Asp Phe

20 25 30

Thr Asn Ala Asn Ser Asn Leu Gin He Ala Gly Asn Ala Val Phe Gly

35 40 45

Asn Ser Thr Asn Gly Ser Gin Asn Thr Ala Asn Phe Asn Asn Thr Gly

50 55 60

Ser Val Asn He Ala Gly Asn Ala Thr Phe Asp Asn Val Val Phe Asn 65 70 75 80

Ser Pro Thr Asn Thr Gly Val Lys Gly Lys Val Thr Leu Asn Asn He

85 90 95

Thr Leu Lys Thr 100

(2) INFORMATION FOR SEQ ID NO: 508:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 123 ammo acids

(D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...123

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 508:

Trp Ala Met Asn Val Trp Val Tyr Arg Pro Leu Leu Ala Phe Met Asp

1 5 10 15

Asn Arg Gin Ala Glu He Lys Asp Ser Leu Ala Lys He Lys Thr Asp

20 25 30

Asn Thr Gin Ser Val Glu He Gly His Gin He Glu Thr Leu Leu Lys

35 40 45

Glu Ala Ala Glu Lys Arg Arg Glu Met Leu Ala Glu Ala He Gin Lys

50 55 60

Ala Thr Glu Ser Tyr Asp Ala Val He Lys Gin Lys Glu Asn Glu Leu 65 70 75 80

Asn Gin Glu Phe Glu Ala Phe Ala Lys Gin Leu Gin Asn Glu Lys Gin 85 90 95

He Leu Lys Glu Gin Leu Gin Ala Gin Met Thr Val Phe Glu Asp Glu

100 105 110

Leu Asn Lys Arg Val Ala Met Gly Leu Gly Ser 115 120

(2) INFORMATION FOR SEQ ID NO: 509:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 103 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...103

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 509 :

Lys Gly Gly Phe He Ser Ala Lys Ser Cys Leu Ser Met Ala Ser Gly

1 5 10 15

Leu Phe Glu Asn Asp Glu He Lys Asn Asn Lys Ala Arg Asp Phe Phe

20 25 30

Tyr Ser His Ser Ser Leu He Val Phe Phe Leu Leu Leu Leu Gly Phe

35 40 45

Gly Tyr Tyr Leu Gly Lys Leu Leu Phe Gly Gly Ser Ser Leu Glu Val

50 55 60

Tyr Leu Asp Leu Arg Asp Lys His Glu Arg Leu Gin Gin Glu He Thr 65 70 75 80

Glu Leu Gin Ser Lys Asn Val Arg Leu Gin Lys Arg Leu Phe Glu Leu

85 90 95

Arg Glu Leu Arg Pro Arg Asp 100

(2) INFORMATION FOR SEQ ID NO: 510:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 332 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature (B) LOCATION 1...332

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:510:

Leu Tyr Tyr Asn Ser Gin Leu Asn Trp Gly Phe Thr Asp Leu Ser Leu

1 5 10 15

Cys Glu Leu Trp Leu Ser Phe Val Arg Asn Glu Met He Lys Ser Trp

20 25 30

Thr Lys Lys Trp Phe Leu He Leu Phe Leu Met Ala Ser Cys Phe Gly

35 40 45

His Leu Val Ala Thr Thr Gly Glu Lys Tyr Phe Lys Met Ala Asn Gin

50 55 60

Ala Leu Lys Arg Gly Asp Tyr His Arg Ala Val Ala Phe Tyr Lys Arg 65 70 75 80

Ser Cys Asn Leu Arg Met Gly Val Gly Cys Thr Ser Leu Gly Ser Met

85 90 95

Tyr Glu Tyr Gly Asp Gly Val Asp Gin Asn He Ser Lys Ala Val Phe

100 105 110

Tyr Tyr Arg Arg Gly Cys Asn Leu Arg Asn Tyr Leu Ala Cys Ala Ser

115 120 125

Leu Gly Ser Met Tyr Glu Asp Gly Asp Gly Val Gin Lys Asp Phe Pro

130 135 140

Lys Ala He Tyr Tyr Tyr Arg Arg Gly Cys His Leu Lys Gly Gly Val 145 150 155 160

Ser Cys Gly Ser Leu Gly Phe Met Tyr Phe Asn Gly Thr Gly Val Lys

165 170 175

Gin Asn Tyr Ala Lys Ala Leu Ser Phe Ser Lys Tyr Ala Cys Ser Leu

180 185 190

Asn Tyr Gly He Ser Cys Asn Phe Val Gly Tyr Met Tyr Lys Ser Ala

195 200 205

Lys Gly Val Glu Lys Asp Leu Lys Lys Ala Leu Ala Asn Phe Lys Arg

210 215 220

Gly Cys His Leu Lys Asp Gly Ala Ser Cys Val Ser Leu Gly Tyr Leu 225 230 235 240

Tyr Glu Ala Gly Met Asp Val Lys Gin Asn Glu Glu Gin Ala Leu Asn

245 250 255

Leu Tyr Lys Lys Gly Cys Ser Leu Lys Glu Gly Ser Gly Cys His Asn

260 265 270

Val Ala Val Met Tyr Tyr Thr Gly Lys Gly Ala Pro Lys Asp Leu Glu

275 280 285

Lys Ala Thr Ser Tyr Tyr Lys Lys Gly Cys Ala Leu Gly Phe Ser Gly

290 295 300

Ser Cys Lys Val Leu Glu Val He Gly Lys Glu Ser Asp Asn Leu Gin 305 310 315 320

Asp Asp Ala Gin Asn Asp Thr Gin Asp Ser Val Gin 325 330

(2) INFORMATION FOR SEQ ID NO: 511:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 94 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL : YES (vi) ORIGINAL SOURCE:

(A) OPGANISM: Helicobacter pylori

(ix) FEATURE.

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...94

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 511 :

He Lys Val Arg Ser Val Lys Lys Thr Glu Arg Gly Leu Leu He Glu

1 5 10 15

Lys Phe Thr Ser Gin Gly Glu Leu Val Pro Leu Glu He Val Val Glu

20 25 30

Thr He Leu Ser Glu He Lys Ser Ser Ser Lys Gly He He Leu He

35 40 45

Asp Gly Tyr Pro Arg Ser Val Glu Gin Met Gin Ala Leu Asp Lys Glu

50 55 60

Leu Asn Ala Pro Asn Glu Val He Leu Lys Ser Val He Glu Val Glu 65 70 75 80

Val Ser Glu Asn Thr Ala Lys Glu Arg Val Leu Gly Gin Phe 85 90

(2) INFORMATION FOR SEQ ID NO: 512:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 113 ammo acids

(D) TOPOLOGY: linear

(u) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...113

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 512:

His Phe Val Phe Arg Gly Asp Phe Cys Trp Ala Tyr Arg Tyr Tyr Ser

1 5 10 15

He Asp Lys Glu Arg Glu Thr Gin Arg His Asp Ser Ser Tyr He Val

20 25 30

He Asp Glu Leu Val Gly Met Cys Leu Ala Met Ala He Asn Gly Leu

35 40 45

Ser Leu Val Gly Val He Leu Ser Phe He Phe Leu Gly Cys Tyr Asp

50 55 60

He Thr Lys Pro Ser Leu He Gly Lys He Asp Lys Glu Val Lys Gly 65 70 75 80

Gly Leu Gly Val Val Ala Asp Asp Ala Leu Ala Gly Val Leu Ala Gly

85 90 95

Leu Ser Thr Leu Leu Ala He Asn He Leu Gly Phe Phe Asn He Lys 100 105 110 Phe

(2) INFORMATION FOR SEQ ID NO: 513:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 79 ammo acids

(D) TOPOLOGY, linear

(n) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(Vl) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...79

( i ) SEQUENCE DESCRIPTION: SEQ ID NO: 513:

Met Trp Pro Val Ala Leu Lys Gin Pro Asn Arg Val Ser His His Phe

1 5 10 15

Tyr He Met Ala Met Leu Phe He Leu Phe Asp Val Glu He Val Phe

20 25 30

Met Phe Pro Trp Ala He Asp Phe Lys Lys Leu Gly Leu Phe Gly Leu

35 40 45

Val Glu Met Leu Gly Phe Val Phe Phe Leu Ala He Gly Phe He Tyr

50 55 60

Ala Leu Lys Arg Asn Ala Leu Ser Trp Gin Lys Leu Glu Val Lys 65 70 75

(2) INFORMATION FOR SEQ ID NO: 514:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 60 ammo acids

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(Vl) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: m sc_feature

(B) LOCATION 1...60

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 514:

Phe Asp Leu Gly Val Arg Thr Asn Phe Ala Lys Thr Asn Phe Asn Lys

1 5 10 15

His Arg Leu Asp Gin Gly He Glu Phe Gly Val Lys He Pro Val He 20 25 30

Ala His Lys Tyr Phe Ala Thr Gin Gly Ser Ser Ala Ser Tyr Met Arg

35 40 45

Asn Phe Ser Phe He Cys Gly Leu Phe Ser Arg Phe 50 55 60

(2) INFORMATION FOR SEQ ID NO: 515:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 148 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...148

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 515 :

Phe Gly Ser Arg Ala Phe Arg Arg He Phe Thr Lys Trp Gly Glu Arg

1 5 10 15

Asp Phe Arg Lys Gly Ala Val Val Leu Met Arg Leu Leu He Ala Leu

20 25 30

Val Leu Phe Leu Trp Trp Leu Asn Leu Gly Ala Lys Glu Ala Asp Phe

35 40 45

He Ser Asp Trp Glu Tyr Gly Leu Ala Leu Tyr Lys Asn Pro Arg Gly

50 55 60

Val Ala Cys Ala Lys Cys His Gly He Lys Gly Glu Gin Gin Glu He 65 70 75 80

Thr Phe Tyr Tyr Glu Lys Gly Glu Lys Lys He Leu Tyr Ala Pro Lys

85 90 95

He Asn His Leu Asp Phe Lys Thr Phe Lys Asp Ala Leu Ser Leu Gly

100 105 110

Phe Cys Met Met Pro Thr Tyr Asn Leu Asn Leu Glu Glu He Gin Ala

115 120 125

He Tyr Leu Tyr He Thr Ser Leu Gly His Lys Asp Glu Arg Lys Asp

130 135 140

Pro Ser Lys Pro 145

(2) INFORMATION FOR SEQ ID NO: 516:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 172 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...172

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 516:

Lys Asn Arg His Lys Leu Leu Tyr Leu Leu Leu Lys Asn Leu Asn Phe

1 5 10 15

Leu Lys Thr He Ser Thr He Phe Thr Gin Lys Arg Val He He Arg

20 25 30

Ser Gin Gin Gly Phe Ser Cys Tyr Leu Asn Leu Lys Val Lys Thr Met

35 40 45

Lys Lys Leu Ala Ala Leu Phe Leu Val Ser Ala Leu Gly Val Met Ser

50 55 60

Leu Asn Ala Trp Glu Gin Thr Leu Lys Ala Asn Asp Leu Glu Val Lys 65 70 75 80

He Lys Ser Val Gly Asn Pro He Lys Gly Asp Asn Thr Phe Val Leu

85 90 95

Ser Pro Thr Leu Lys Gly Lys Ala Leu Glu Lys Ala He Val Arg Val

100 105 110

Gin Phe Met Met Pro Glu Met Pro Gly Met Pro Ala Met Lys Glu Met

115 120 125

Ala Gin Val Ser Glu Lys Asn Gly Leu Tyr Glu Ala Lys Thr Asn Leu

130 135 140

Ser Met Asn Gly Thr Trp Gin Val Arg Val Asp He Lys Ser Lys Glu 145 150 155 160

Gly Gin Val Tyr Arg Thr Lys Thr Ser Leu Asp Leu 165 170

(2) INFORMATION FOR SEQ ID NO: 517:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 74 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...74

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 517:

Cys Leu Phe Val Leu Thr Lys Ser Gin Arg He Arg Met Lys Arg Leu 1 5 10 15

Leu Leu Leu Ala Leu Ala Leu Phe Phe Ser Leu Ser Cys Thr Asn Ala 20 25 30 Gin Glu He Lys Glu Thr Gin Glu Thr Lys Lys Thr Lys Glu Thr Lys

35 40 45

Ser Gin Thr Arg Phe Asn He Ser Thr Thr Lys Val He Glu Lys Glu

50 55 60

Phe Ser Gin Ser Arg Arg Tyr Tyr Ala Leu 65 70

(2) INFORMATION FOR SEQ ID NO: 518:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 293 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...293

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 518 :

He Lys Phe Ala Lys Lys He Val Leu He Leu Lys Lys Gly Gly Phe

1 5 10 15

Met Lys Thr Asn Gly Leu Phe Lys Met Trp Gly Leu Phe Leu Val Leu

20 25 30

He Ala Leu Val Phe Asn Ala Cys Ser Asp Ser His Lys Glu Lys Lys

35 40 45

Asp Ala Leu Glu Val He Lys Gin Arg Gly Val Leu Lys Val Gly Val

50 55 60

Phe Ser Asp Lys Pro Pro Phe Gly Ser Val Asp Ser Lys Gly Asn Tyr 65 70 75 80

Gin Gly Tyr Asp Val Val He Ala Lys Arg Met Ala Leu Asp Leu Leu

85 90 95

Gly Asp Glu Asn Lys He Glu Phe He Pro Val Glu Ala Ser Ala Arg

100 105 110

Val Glu Phe Leu Lys Ala Asn Lys Val Asp He He Met Ala Asn Phe

115 120 125

Thr Arg Thr Lys Glu Arg Glu Lys Val Val Asp Phe Ala Asn Pro Tyr

130 135 140

Met Lys Val Ala Leu Gly Val He Ser Lys Asp Gly Val He Lys Asn 145 150 155 160

He Glu Glu Leu Lys Asp Lys Glu Leu He Val Asn Lys Gly Thr Thr

165 170 175

Ala Asp Phe Tyr Phe Thr Lys Asn Tyr Pro Asn He Lys Leu Leu Lys

180 185 190

Phe Glu Gin Asn Thr Glu Thr Phe Leu Ala Leu Leu Asn Asn Lys Ala

195 200 205

He Ala Leu Ala His Asp Asn Thr Leu Leu Leu Ala Trp Val Lys Gin

210 215 220

His Pro Glu Phe Lys Leu Gly He Thr Ser Leu Gly Asp Lys Asp Val 225 230 235 240 He Ala Pro Ala He Lys Lys Gly Asn Pro Lys Leu Leu Glu Trp Leu

245 250 255

Asn Asn Glu He Asp Ser Leu He Ser Ser Asp Phe Leu Lys Glu Ala

260 265 270

Tyr Gin Glu Thr Leu Glu Pro He Tyr Gly Asp Gly He Lys Pro Glu

275 280 285

Glu He He Phe Glu 290

(2) INFORMATION FOR SEQ ID NO: 519:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 676 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...676

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 519:

Ala Phe Glu Glu Leu Glu Pro Leu Ser Phe Ser Phe Asn Ser Pro Lys

1 5 10 15

Gly Ala Cys Glu Ser Cys Leu Gly Leu Gly Thr Lys Phe Ser Leu Asp

20 25 30

He Ser Lys He Leu Asp Pro Asn Thr Pro Leu Asn Gin Gly Ala He

35 40 45

Lys Val He Phe Gly Tyr Asn Arg Ser Tyr Tyr Ala Gin Met Phe Glu

50 55 60

Gly Phe Cys Thr Tyr Asn Gly He Asp Ser Ala Leu Cys Phe Asn Glu 65 70 75 80

Leu Asn Lys Glu Gin Gin Asp Ala Leu Leu Tyr Gly Asn Gly Thr Glu

85 90 95

He Ser Phe His Phe Lys Asn Ser Pro Leu Lys Arg Pro Trp Lys Gly

100 105 110

He He Gin He Ala Tyr Asp Met Phe Lys Glu Gin Lys Asp Leu Ser

115 120 125

Asp Tyr Met Ser Glu Lys Thr Cys Ser Ser Cys Asn Gly His Arg Leu

130 135 140

Lys Ala Ser Ser Leu Ser Val Gin Val Ala Gly Leu Lys Met Ala Asp 145 150 155 160

Phe Leu Thr Lys Pro He Glu Glu Val Tyr His Phe Phe Asn Asp Pro

165 170 175

Thr His Phe Asn Tyr Leu Asn Glu Gin Glu Lys Lys He Ala Glu Pro

180 185 190

He Leu Lys Glu He Leu Glu Arg Val Phe Phe Leu Tyr Asp Val Gly

195 200 205

Leu Gly Tyr Leu Thr Leu Gly Arg Asp Ala Arg Thr He Ser Gly Gly 210 215 220 Glu Ser Gin Arg He Arg He Ala Ser Gin He Gly Ser Gly Leu Thr 225 230 235 240

Gly Val Leu Tyr Val Leu Asp Glu Pro Ser He Gly Leu His Glu Lys

245 250 255

Asp Thr Leu Lys Leu He Asn Thr Leu Arg Asn Leu Gin Lys Lys Gly

260 265 270

Asn Thr Leu He Val Val Glu His Asp Lys Glu Thr He Lys His Ala

275 280 285

Asp Phe Val Val Asp He Gly Pro Lys Ala Gly Arg His Gly Gly Glu

290 - 295 300

Val Val Phe Ser Gly Ser Val Lys Asp Leu Leu Gin Asn Asn His Ser 305 310 315 320

Thr Ala Leu Tyr Leu Asn Gly Thr Lys Lys He Glu Arg Pro Lys Phe

325 330 335

Glu Pro Pro Lys Glu Lys His Phe Leu Glu He Lys Asn Val Asn He

340 345 350

Asn Asn He Lys Asn Leu Ser Val Gin He Pro Leu Lys Gin Leu Val

355 360 365

Cys He Thr Gly Val Ser Gly Ser Gly Lys Ser Ser Leu He Leu Gin

370 375 380

Thr Leu Leu Pro Thr Ala Gin Thr Leu Leu Asn His Ala Lys Lys Asn 385 390 395 400

Gin Ser Leu Asn Gly Val Glu He Val Gly Leu Glu Tyr Leu Asp Lys

405 410 415

Val He Tyr Leu Asp Gin Ala Pro He Gly Lys Thr Pro Arg Ser Asn

420 425 430

Pro Ala Thr Tyr Thr Gly Val Met Asp Glu He Arg He Leu Phe Ala

435 440 445

Glu Gin Lys Glu Ala Lys He Leu Gly Tyr Ser Thr Ser Arg Phe Ser

450 455 460

Phe Asn Val Lys Gly Gly Arg Cys Glu Lys Cys Gin Gly Asp Gly Asp 465 470 475 480

He Lys He Glu Met His Phe Leu Pro Asp Val Leu Val Gin Cys Asp

485 490 495

Ser Cys Lys Gly Ala Lys Tyr Asn Pro Gin Thr Leu Glu He Lys Val

500 505 510

Lys Gly Lys Ser He Ala Asp Val Leu Asn Met Ser Val Glu Glu Ala

515 520 525

Tyr Glu Phe Phe Ala Lys Phe Pro Lys He Ala Val Lys Leu Lys Thr

530 535 540

Leu He Asp Val Gly Leu Gly Tyr He Thr Leu Gly Gin Asn Ala Thr 545 550 555 560

Thr Leu Ser Gly Gly Glu Ala Gin Arg He Lys Leu Ala Lys Glu Leu

565 570 575

Ser Lys Lys Asp Thr Gly Lys Thr Leu Tyr He Leu Asp Glu Pro Thr

580 585 590

Thr Gly Leu His Phe Glu Asp Val Asn His Leu Leu Gin Val Leu His

595 600 605

Ser Leu Val Ala Leu Gly Asn Ser Met Leu Val He Glu His Asn Leu

610 615 620

Asp He He Lys Asn Ala Asp Tyr He He Asp Met Gly Pro Asp Gly 625 630 635 640

Gly Asp Lys Gly Gly Lys Val He Ala Ser Gly Thr Pro Leu Glu Val

645 650 655

Ala Gin Asn Cys Glu Lys Thr Gin Ser Tyr Thr Gly Lys Phe Leu Ala

660 665 670

Leu Glu Leu Lys 675 (2) INFORMATION FOR SEQ ID NO : 520-

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 138 ammo acids

(B) TYPE, ammo acid (D) TOPOLOGY, linear

(ii) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...138

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 520 :

He He He Asp Tyr Ser Ser Gin Tyr Phe Ser Gly Arg Ala Ala Ala

1 5 10 15

Phe Tyr Gin Ala Leu Asp Asn Phe He Ser Arg Tyr Ala Gin Arg Leu

20 25 30

He Val Thr Asn Leu Ser Gin Ala He Arg He Tyr Gly Tyr Glu Val

35 40 45

Gly Gly Thr Phe Arg Tyr Lys Gly Val Ser Leu Asn Val Gly He Ser

50 55 60

Arg Thr Trp Pro Thr Thr Arg Gly Tyr Leu Met Ala Asp Ser Tyr Glu 65 70 75 80

Leu Ala Ala Ser Thr Gly Asn Val Phe He He Lys Leu Asp Tyr Thr

85 90 95

He Ser Lys Asn Arg Asp Gin Ser Cys Met Ala Leu Ala Ala Leu Leu

100 105 110

Pro Val Trp He He Ala Gly Leu He Phe Thr Cys Leu He Met Gly

115 120 125

Gin Leu Lys Asn Pro Lys Pro Leu Pro He 130 135

(2) INFORMATION FOR SEQ ID NO: 521:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 173 ammo acids

(D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(ill) HYPOTHETICAL : YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature ( B ) LOCATION 1 . . . 173

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 521 :

Gin Gly Met Gly Leu Lys Asn Leu Ser Thr Leu Leu Val Phe Leu Phe

1 5 10 15

Phe Cys Leu Gly Cys Val Ser Asn Phe Asn Glu Asp Thr Tyr Thr Leu

20 25 30

Asp Leu Val Leu Glu Lys Lys He Gin Ala Ser Arg Lys Gly Glu He

35 40 45

Thr Gin Asp Asn Val Pro He He Thr Ala He Ala Thr His Leu Asn

50 55 60

Asp Val Asp Ser Gly Thr Tyr Tyr Asp His Glu Tyr Phe Leu Val Glu 65 70 75 80

He Phe Thr Gin Asn Asn Asp Trp He Asp Asp Gly Tyr He Ser Tyr

85 90 95

Glu Leu Phe Gly Thr Lys Pro Thr Gly Ser Glu Pro Leu Trp Val Arg

100 105 110

Glu He Thr Arg Asp Glu Phe Asp Gly He Leu Glu Thr Thr Asn Arg

115 120 125

Trp Ser Arg Ala Phe Leu He Ala Phe Asp Lys Leu Asp Tyr Leu Ala

130 135 140

Val Gin Glu Ala Lys Leu Glu Leu Asp Ala Tyr Ser Leu Gly Lys He 145 150 155 160

Val Phe Asn Phe Ala Tyr Gin Val Pro Leu Pro Gin Phe 165 170

(2) INFORMATION FOR SEQ ID NO: 522:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 109 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...109

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 522 :

Gin Lys Glu Val Ser Asn Tyr Glu Glu Ser He Leu Val Asn Thr Pro

1 5 10 15

Tyr Ala Arg Val Asn He Leu Ala He Glu Lys Asn Glu Ser Pro He

20 25 30

Glu Leu Leu Ala Pro Val Asp Leu Val Thr Ala Leu Ser Asp Leu Met

35 40 45

Leu Gly Gly Glu Gly Ala Ser Lys Glu Glu Met Asp Asn Asp Asp Leu

50 55 60

Asp Ala Phe Lys Glu Met Ala Ser Asn He Phe Gly Ala He Ala Thr 65 70 75 80 Ser Leu Lys Ser Gin Glu Leu Leu Pro Lys Leu Asn Phe Thr Thr Thr

85 90 95

Asn Ala Glu He Ala Lys Glu Leu Pro Lys Lys Glu Asp

100 105

(2) INFORMATION FOR SEQ ID NO: 523:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 182 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...182

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 523 :

He Cys Leu Leu Lys Glu Lys He Met Ser Asn Ser Met Leu Asp Lys

1 5 10 15

Asn Lys Ala He Leu Thr Gly Gly Gly Ala Leu Leu Leu Gly Leu He

20 25 30

Val Leu Phe Tyr Leu Ala Tyr Arg Pro Lys Ala Glu Val Leu Gin Gly

35 40 45

Phe Leu Glu Ala Arg Glu Tyr Ser Val Ser Ser Lys Val Pro Gly Arg

50 55 60

He Glu Lys Val Phe Val Lys Lys Gly Asp Arg He Lys Lys Gly Asp 65 70 75 80

Leu Val Phe Ser He Ser Ser Pro Glu Leu Glu Ala Lys Leu Ala Gin

85 90 95

Ala Glu Ala Gly His Lys Ala Ala Lys Ala Val Ser Asp Glu Val Lys

100 105 110

Arg Gly Ser Arg Asp Glu Thr He Asn Ser Ala Arg Asp Val Trp Gin

115 120 125

Ala Ala Lys Ser Gin Ala Asn Leu Ala Lys Glu Thr Tyr Lys Arg Val

130 135 140

Gin Asp Leu Tyr Asp Asn Gly Val Ala Ser Leu Gin Lys Arg Asp Glu 145 150 155 160

Ala Tyr Ala Ala Met Lys Ala Pro Asn Thr Thr Arg Ala Arg Leu Thr

165 170 175

Lys Ser He Lys Trp Leu 180

(2) INFORMATION FOR SEQ ID NO: 524:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 148 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL : YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...148

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 524:

Met Glu Phe Leu Ser Gly Tyr Phe Leu Trp Val Lys Ala Phe His Val

1 5 10 15

He Ala Val He Ser Trp Met Ala Ala Leu Phe Tyr Leu Pro Arg Leu

20 25 30

Phe Val Tyr His Ala Glu Asn Ala His Lys Lys Glu Phe Val Gly Val

35 40 45

Val Gin He Gin Glu Lys Lys Leu Tyr Ser Phe He Ala Ser Pro Ala

50 55 60

Met Gly Phe Thr Leu He Thr Gly He Leu Met Leu Leu He Ala Pro 65 70 75 80

Glu Met Phe Lys Ser Gly Gly Trp Leu His Ala Lys Leu Ala Leu Val

85 90 95

Val Leu Leu Leu He Tyr His Phe Tyr Cys Lys Lys Cys Met Arg Glu

100 105 110

Leu Glu Lys Asp Pro Thr Gly Lys Asn Ala Arg Phe Tyr Arg Val Phe

115 120 125

Asn Glu He Pro Thr He Leu Met He Leu He Val He Leu Val Val

130 135 140

Val Lys Pro Phe 145

(2) INFORMATION FOR SEQ ID NO: 525:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 291 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...291

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 525 :

Gly Leu Thr He Arg Gin Ala Phe Asn Lys Thr Arg Ser Thr His Ser

1 5 10 15

Arg Thr Leu Leu Leu Asp He Asp Cys Val He Pro Asn He Val Arg 20 25 30

Arg Leu Leu Ser Asn Lys Thr Leu Pro Lys Arg Phe Ala Thr Tyr Ser

35 40 45

Leu Gin Glu Val Gly Val He Phe Leu Thr Thr Gin He Leu Ser He

50 55 60

Met Arg Lys Thr Arg Cys Ser Lys Thr Leu Phe Phe He Thr Arg Gly 65 70 75 80

Arg Glu Ser Phe Arg Tyr Gin Leu Cys Asp His Tyr Lys Gin Lys Arg

85 90 95

His Gin Phe Asp Glu Asp Phe Arg Ser Leu Leu Lys Ala Leu Lys He

100 105 110

Ala Leu Val Glu Lys Tyr Pro Leu Lys Lys Gly Ala Lys He Gin Gly

115 120 125

Glu His Cys Phe Glu Tyr Glu Ala Asp Asp He He Ser Phe Tyr Lys

130 135 140

Lys Lys Asp Pro Asn Asn Tyr Val He Ala Ser Met Asp Lys Asp He 145 150 155 160

Leu Tyr Ser Asn Arg Gly Ser His Phe Asn Leu Lys Thr Asn Ala Phe

165 170 175

Phe Asn Val Ser Gin Lys Glu Ala His Phe Phe Ala Tyr Tyr Gin Cys

180 185 190

Val Val Gly Asp Lys Gly Asp Asn He Lys Gly Val Lys Gly He Gly

195 200 205

Gly Phe Asn Tyr Lys Asp Phe Leu Asn Glu Asp Ala Lys Glu His Glu

210 215 220

Leu Trp Glu Gin He He Gin Ala Phe Lys He Lys Glu Asp Leu Ser 225 230 235 240

Asp Ser Glu Ala Lys Glu Lys Ala Leu Leu Asn Met Arg Leu Val Asn

245 250 255

Met His Gin Met Thr His His Gly Val He Lys Leu Trp Glu Pro Glu

260 265 270

Phe Lys Lys Ala Phe Phe Pro Lys Lys Pro Gin Arg Pro Asp Phe Lys

275 280 285

Arg He Ser 290

(2) INFORMATION FOR SEQ ID NO: 526:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 193 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...193

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:526: Gly Val Tyr His Asn Lys Glu He He Val Ala Tyr Arg Lys He Gly 1 5 10 15

Lys Val His Ser Thr Leu Thr Thr Thr Ser Met He Leu Ala Phe Gly

20 25 30

Val Gin Lys Val Leu Phe Ser Gly Val Ala Gly Ser Leu Val Lys Asp

35 40 45

Leu Lys He Asn Asp Leu Leu Val Ala Thr Gin Leu Val Gin His Asp

50 55 60

Val Asp Leu Ser Ala Phe Asp His Pro Leu Gly Phe He Pro Glu Ser 65 70 75 80

Ala He Phe He Glu Thr Ser Gly Ser Leu Asn Ala Leu Ala Lys Lys

85 90 95

He Ala Asn Glu Gin His He Ala Leu Lys Glu Gly Val He Ala Ser

100 105 110

Gly Asp Gin Phe Val His Ser Lys Glu Arg Lys Glu Phe Leu Val Ser

115 120 125

Glu Phe Lys Ala Ser Ala Val Glu Met Glu Gly Ala Ser Val Ala Phe

130 135 140

Val Cys Gin Lys Phe Gly Val Pro Cys Cys Val Leu Arg Ser He Ser 145 150 155 160

Asp Asn Ala Asp Glu Lys Ala Gly Met Ser Phe Asp Glu Phe Leu Glu

165 170 175

Lys Ser Ala His Thr Ser Ala Lys Phe Leu Lys Ser Met Val Asp Glu

180 185 190

Leu

(2) INFORMATION FOR SEQ ID NO: 527:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 80 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...80

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 527:

Lys Leu Ala Leu Phe Lys Gin Arg Gin Leu Lys Gin Asn Lys Asn Ala

1 5 10 15

Gin Ala Asn Pro Lys Ser Pro Phe He Thr His Val Val Leu Pro Lys

20 25 30

Glu Thr Leu Ser Ser He Ala Lys Arg Tyr Gin Val Ser He Ser Ser

35 40 45

He Gin Leu Ala Asn Asn Leu Lys Asp Ser Asn He Phe He His Gin

50 55 60

Arg Leu He He Pro Thr Asn Lys Lys Leu Leu Ala Thr Arg Glu Phe 65 70 75 80 (2) INFORMATION FOR SEQ ID NO.528

(l) SEQUENCE CHARACTERISTICS.

(A) LENGTH 245 ammo acids

(D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...245

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 528 :

Gly His Arg Lys Arg He Phe Ser Lys Pro Ala Leu Leu Arg Ala Leu

1 5 10 15

Glu Pro Asn Glu Ala Leu He Phe Ser Gin Thr Leu Arg Phe Asp Gly

20 25 30

Tyr Val Glu Lys Leu Tyr Ala Asn Lys Thr Tyr Thr Pro He Lys Lys

35 40 45

Gly Asp Arg Leu Leu Ser Val Tyr Ser Pro Glu Leu Ala Gly Val Gin

50 55 60

Ser Glu Leu Leu Ser Ser Leu Lys Phe Asn Gin Gin Val Gly Ala He 65 70 75 80

Lys Glu Lys Leu Lys Leu Leu Gly Leu Glu Asn Phe Ser He Glu Lys

85 90 95

He He Ser Ser His Lys Val Gin Asn Glu He Thr He Tyr Ser Arg

100 105 110

Phe Asn Gly Val He Phe Lys Lys Ser Pro Asp Leu Asn Glu Gly Ser

115 120 125

Phe He Lys Lys Gly Gin Glu Leu Phe Lys He He Asp Leu Ser Arg

130 135 140

Leu Trp Ala Leu Val Lys Val Asn Gin Glu Asp Leu Glu Phe Leu Lys 145 150 155 160

Asn Thr His Gin Ala He Leu Phe Val Glu Gly Val Lys Gly Lys Gin

165 170 175

Ala He Thr Leu Glu Asn He Asn Pro He He Asn Ala Gin Asp Lys

180 185 190

Met Leu Glu Ala Arg Phe Asn Val Pro Asn Leu Lys Leu Leu Tyr Tyr

195 200 205

Pro Asn Met Phe Ala Gin Val Glu He Phe His Lys Pro Gin Lys Met

210 215 220

Lys He Leu Pro Lys Glu Ala Val Leu He Lys Gly Gly Lys Ala He 225 230 235 240

Val Phe Lys Lys Asp 245

(2) INFORMATION FOR SEQ ID NO: 529:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH- 152 ammo acids

(D) TOPOLOGY linear

(11) MOLECULE TYPE: protein

(m) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM. Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY. mιsc_feature

(B) LOCATION 1...152

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 529 :

Ser Gly Glu His Thr Met Lys Lys Tyr He Leu Asn Leu Ala Leu Val

1 5 10 15

Gly Ala Leu Ser Ala Ser Phe Leu Met Ala Lys Pro Ala His Asn Ala

20 25 30

Asn Asn Ser Thr His Asn Thr Lys Glu Thr Thr Asp Ala Ser Ala Gly

35 40 45

Val Leu Ala Thr Val Asp Gly Arg Pro He Thr Lys Ser Asp Phe Asp

50 55 60

Met He Lys Gin Arg Asn Pro Asn Phe Asp Phe Asp Lys Leu Lys Glu 65 70 75 80

Lys Glu Lys Glu Ala Leu He Glu Gin Ala He Arg Thr Ala Leu Val

85 90 95

Glu Asn Glu Ala Lys Ala Glu Lys Leu Asn Gin Thr Pro Glu Phe Lys

100 105 110

Ala Met Met Glu Ala Val Lys Lys Gin Ala Leu Val Glu Phe Trp Ala

115 120 125

Lys Lys Gin Ala Glu Glu Val Lys Lys Asp Pro Asn Pro Arg Lys Arg

130 135 140

Asn Ala Gly Phe Leu Gin Arg Gin 145 150

(2) INFORMATION FOR SEQ ID NO: 530:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 184 ammo acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...184

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 530: Arg Ala Leu Lys Thr His Gly Ala Leu Ala Phe Val Gin Ala Phe Leu

1 5 10 15

Glu Ser Phe Lys Gly Phe Leu Ser Gin Ala Thr Leu He Ser Val Leu

20 25 30

He Ala Ser Val Leu He Leu Phe Cys Ala He Leu Leu Leu Leu Ala

35 40 45

Leu Leu Leu Arg Asn Arg Trp Ala Ser Tyr He Thr Thr Ala Ala Phe

50 55 60

Leu Gly Ala Phe Leu Ser Met Pro Phe Val Leu Asn Val Leu Leu Thr 65 70 75 80

Gin Ala He Tyr Pro He Glu Thr Arg He Leu His Ala Asn Pro Leu

85 90 95

Ser Tyr Ser Asn Ala Phe Ser Leu Gin Val Gly Val Lys Asn He Ser

100 105 110

Lys Phe Ser Leu Asn Lys Cys Val Leu Arg Leu Glu Val Leu Lys Asn

115 120 125

Pro His Asn Phe Val Glu Glu Arg Ala Phe Lys Trp Phe Val Lys Lys

130 135 140

Ser Tyr Glu Lys Thr Phe Lys Glu Lys He Leu Pro Glu Glu Ser Lys 145 150 155 160

Val Phe Ser Phe Phe He Asp Asp Tyr Pro Tyr Ser Lys Thr Ala Pro

165 170 175

Tyr Gin Val Ser Leu Phe Cys Leu 180

(2) INFORMATION FOR SEQ ID NO: 531:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 115 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...115

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 531 :

Ala Met Asn He Lys Thr His Ser Ser Asn Glu Lys Glu Arg Phe Val

1 5 10 15

Arg He Glu Glu Asp Glu Lys Lys Glu Leu Phe Ala Glu Ala Thr Asn

20 25 30

Glu Asn Pro His Gly Leu Ser Leu Met Ala Leu He Gly Val Leu Val

35 40 45

Phe Gly Gly Ala Phe Leu Ala Leu Leu Val Pro Lys He Tyr Leu Ser

50 55 60

Asn Asn He Tyr Tyr He Ser Arg Lys He Asn Thr Leu Glu Asp Gin 65 70 75 80

Lys Arg Leu Leu Leu Glu Glu Gin Gin He Leu Lys Asn Glu Leu Glu 85 90 95 Lys Glu Arg Phe Lys Tyr Tyr He Glu Asn Ser Glu Asn He Gly Asp

100 105 110

He Ala Phe 115

(2) INFORMATION FOR SEQ ID NO: 532:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 238 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...238

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 532 :

Leu Leu Leu He His Phe Leu He Leu Arg Lys Leu Leu Gin His Lys

1 5 10 15

Thr He Met Asp Lys He He He Gin Gly Ala Arg Glu Asn Asn Leu

20 25 30

Lys Asn He Phe Leu Glu He Pro Lys Asn Gin Phe Val Val Phe Thr

35 40 45

Gly Leu Ser Gly Ser Gly Lys Ser Thr Leu Ala Phe Asp Thr Leu Tyr

50 55 60

Ala Glu Gly Gin Arg Arg Tyr Leu Glu Ser Leu Ser Ser Tyr Ala Arg 65 70 75 80

Gin Phe Leu Asp Lys Val Gly Lys Pro Asn Val Asp Lys He Glu Gly

85 90 95

Leu Thr Pro Ala He Ala He Asp Gin Lys Thr Thr Ser Lys Asn Pro

100 105 110

Arg Ser Thr Val Gly Thr He Thr Glu He Tyr Asp Tyr Leu Arg Leu

115 120 125

Leu Leu Ala Arg Val Gly Glu Gin Phe Cys Pro Thr Cys Leu Glu Pro

130 135 140

He Ser Ser Met Ser Ala Ser Asp He He Ser Gin He Cys His Leu 145 150 155 160

Glu Glu Asn Ser Lys He He He Leu Ala Pro He He Lys Asp Lys

165 170 175

Lys Gly Ser Phe Asn Asp Lys Leu Glu Ser Leu Arg Leu Lys Gly Tyr

180 185 190

Val Arg Ala Phe Val Asp Gly Val Met Val Arg Leu Asp Glu Glu He

195 200 205

His Leu His Lys Thr Lys Lys His Thr He Glu Ala Val Val Asp Arg

210 215 220

Val Val He Asn Ser Glu Asn Ala Ser Arg He Ala Ser Ala 225 230 235

(2) INFORMATION FOR SEQ ID NO: 533: (l) SEQUENCE CHARACTERISTICS.

(A) LENGTH- 361 ammo acids

(B) TYPE ammo acid (D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(m) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM. Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...361

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 533:

His Gin Ser Phe Lys Arg Ala Phe Glu Pro Arg Arg Lys Gly Arg Val

1 5 10 15

Phe Arg He Met Gly Phe Glu Lys Ser He Leu Asp Asn Leu Asn Gly

20 25 30

Ala Gin Lys He Ala Ala Cys His He Gin Gly Pro Leu Leu He Leu

35 40 45

Ala Gly Ala Gly Ser Gly Lys Thr Lys Thr Leu Thr Ser Arg Leu Ala

50 55 60

Tyr Leu He Gly Ala Cys Gly Val Pro Ser Glu Asn Thr Leu Thr Leu 65 70 75 80

Thr Phe Thr Asn Lys Ala Ser Lys Glu Met Gin Glu Arg Ala Leu Lys

85 90 95

Leu Leu Lys Asn Gin Ala Leu He Pro Pro Leu Leu Cys Thr Phe His

100 105 110

Arg Phe Gly Leu Leu Phe Leu Arg Gin His Met Asn Leu Leu Lys Arg

115 120 125

Ala Cys Asp Phe Ser Val Leu Asp Ser Asp Glu Val Lys Thr Leu Cys

130 135 140

Lys Gin Leu Lys He Ser Asn Phe Arg Ala Ser He Ser Gin He Lys 145 150 155 160

Asn Gly Met Met Asp Leu Ser Val Gin Asp Ser Glu Cys Tyr Lys Ala

165 170 175

Tyr Glu Leu Tyr Gin Asn Ala Leu Lys Lys Asp Asn Leu Val Asp Phe

180 185 190

Asp Asp Leu Leu Cys Leu Ser Leu Lys He Leu Gin Asp Asn Glu Lys

195 200 205

Leu Ala Lys Glu Thr Ser Glu Arg Tyr His Tyr He Met Val Asp Glu

210 215 220

Tyr Gin Asp Thr Asn Ala Leu Gin Leu Glu Phe Leu Lys Gin Leu Ser 225 230 235 240

Phe Thr His His Asn Leu Cys Val Val Gly Asp Asp Asp Gin Ser He

245 250 255

Tyr Gly Phe Arg Gly Ala Asp He Ser Asn He Leu Asn Phe Ser Lys

260 265 270

His Phe Lys Gly Ala Lys He Val Lys Leu Glu Thr Asn Tyr Arg Ser

275 280 285

Ser Ala Glu He Leu Ala Cys Ala Asn Ser Leu He Ser His Asn Gin 290 295 300 His Arg His He Lys Thr Leu Gin Ser Phe Lys Gly Ser His Lys Ser 305 310 315 320

Val He Cys Lys Glu Tyr Pro Thr Gin Lys Glu Glu Ser Leu Asp Val

325 330 335

Ala Tyr Gin He Gin Ser Pro Phe Lys Glu Gly Arg Glu Phe Arg Lys

340 345 350

Tyr Arg Tyr Phe Val Ser Phe Lys Trp 355 360

(2) INFORMATION FOR SEQ ID NO: 534:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 152 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...152

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 534 :

Met Arg Lys Thr He Ser Ala Leu Phe Leu Ser Ala Cys He Gly Leu

1 5 10 15

Ser Ser Val His Ala Ser Asn Ala Leu He Leu Gin Thr Asp Phe Ser

20 25 30

Leu Lys Asp Gly Ala Val Ser Ala Met Lys Gly Val Ala Phe Ser Val

35 40 45

Asp Ser Asn Leu Lys He Phe Asp Leu Thr His Glu He Pro Pro Tyr

50 55 60

Asn He Trp Glu Gly Ala Tyr Arg Leu Tyr Gin Thr Ala Ser Tyr Trp 65 70 75 80

Pro Lys Gly Ser Val Phe Val Ser Val Val Asp Pro Gly Val Gly Thr

85 90 95

Asn Arg Lys Ser Val Val Leu Lys Thr Lys Asn Gly Gin Tyr Phe Val

100 105 110

Ser Pro Asp Asn Gly Thr Leu Thr Leu Val Ala Gin Thr Leu Gly He

115 120 125

Asp Ser Arg Ala Glu He Asp Glu Asn Ser He Arg Leu Lys Gly Ser

130 135 140

Lys Phe Leu Ser Ser Arg Pro Val 145 150

(2) INFORMATION FOR SEQ ID NO: 535:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 243 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear (11) MOLECULE TYPE- protein

(m) HYPOTHETICAL. YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...243

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 535 :

Asp He Phe Asn Lys Glu Glu He Met Ala He Asp Leu Ala Glu Val

1 5 10 15

Thr Gly Ala Lys Ala Ala Gin Glu Arg Lys Lys Glu Gin Pro Thr He

20 25 30

Ala Asn Gly Leu Asp Lys Asn Ala Phe Met Lys Leu Phe Leu Glu Gin

35 40 45

Leu Lys Asn Gin Asp Pro Thr Ala Pro Met Glu Thr Asp Lys He He

50 55 60

Thr Gin Thr Ala Gin Leu Thr Gin Val Glu Met Gin Glu Glu Asn Lys 65 70 75 80

Lys Thr Met Gin Glu Val Ala Ser Ala Met Lys Ser Asn Lys Glu Thr

85 90 95

Asn Glu Ser Leu Lys Asp Phe Gin Gly Ala Leu Lys Asp Thr Met Glu

100 105 110

Asn Leu Asn Lys Gly Met Asp Asp Ser Leu Lys Ala Asn Asn Ala Leu

115 120 125

Arg Glu Val Ser Ala Leu Asn Ser Val Ser Met He Gly Lys He Ala

130 135 140

Glu Thr Asp Val Ser Gly Ala Asn Phe Asp Gly Asn Asn Lys Leu Ser 145 150 155 160

Phe Ser Leu Phe Phe Asp Glu Lys He Asp Ala Ser Lys Gly Val Pro

165 170 175

Ala He Gin He Leu Asn Glu Asn Asn Glu Leu Val Lys Thr He Pro

180 185 190

Leu Lys Asp Tyr Asn Gly Gin Lys Gly Tyr He Asn Phe Glu Trp Asp

195 200 205

Gly Thr Asn Glu Lys Gly Glu Lys Val Pro Lys Gly Asn Tyr Lys He

210 215 220

Lys Ala Glu Tyr Asn Leu Gly Ser Pro Lys Gin Ala Val Phe Ala Asn 225 230 235 240

Ala His Trp

(2) INFORMATION FOR SEQ ID NO: 536:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 253 ammo acids

(D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(m) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE.

(A) NAME/KEY: miscjeature

(B) LOCATION 1...253

(xi) SEQUENCE DESCRIPTION- SEQ ID NO: 536:

Asn Ala His Ala Phe Thr His Pro Phe Ser Ala Pro Ala Arg Phe Arg

1 5 10 15

Leu Ala Gin Lys Arg Lys Asp Asn Thr Leu Pro Phe Leu Arg Pro Asp

20 25 30

Gly Lys Ser Gin Val Ser Val Arg Tyr Glu Asn Asn Lys Pro Val Ser

35 40 45

Val Asp Thr He Val He Ser Thr Gin His Ser Pro Glu Val Ser Gin

50 55 60

Lys His Leu Lys Glu Ala Val He Glu Glu He Val Tyr Lys Val Leu 65 70 75 80

Pro Lys Glu Tyr Leu His Asp Asn He Lys Phe Phe He Asn Pro Thr

85 90 95

Gly Lys Phe Val He Gly Gly Pro Gin Gly Asp Ala Gly Leu Thr Gly

100 105 110

Arg Lys He He Trp Asp Thr Tyr Gly Gly Phe Cys Pro His Gly Gly

115 120 125

Gly Ala Phe Thr Gly Lys Asp Pro Tyr Lys Val Asp Met Ser Ala Ala

130 135 140

Tyr Ala Ala Arg Tyr Val Ala Lys Asn Leu Val Ala Ser Gly Val Cys 145 150 155 160

Asp Lys Ala Thr Val Gin Leu Ala Tyr Ala He Gly Val He Glu Pro

165 170 175

Val Ser He Tyr Val Asn Thr His Asn Thr Ser Lys His Ser Ser Ala

180 185 190

Glu Leu Glu Lys Cys Val Lys Ser Val Phe Lys Leu Thr Pro Lys Gly

195 200 205

He He Glu Ser Leu Asp Leu Leu Arg Pro He Tyr Ser Leu Thr Ser

210 215 220

Ala Tyr Gly His Phe Gly Arg Glu Leu Glu Glu Phe Thr Trp Glu Lys 225 230 235 240

Thr Asn Lys Val Glu Glu He Lys Ala Phe Phe Lys Arg 245 250

(2) INFORMATION FOR SEQ ID NO: 537:

( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 65 ammo acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE: (A) NAME/KEY: misc_feature

(B) LOCATION 1...65

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 537 :

Val He Ser Tyr His Phe He He Leu Lys Asp Val Phe He Met Arg

1 5 10 15

He Lys Ala Tyr Phe Leu Arg Leu Ser His Trp Phe Leu Ser Phe Gly

20 25 30

Trp Val Leu Ala Leu Val Lys Thr Leu Lys Asn Leu Lys He Leu Lys

35 40 45

Thr He Pro Pro Asn Lys He Ala Leu Lys Pro Thr Pro Tyr Gly Ser

50 55 60

Glu 65

(2) INFORMATION FOR SEQ ID NO: 538:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 122 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL : YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...122

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 53 8 :

Lys Gly He Ser Met Lys Lys Ser Leu Cys Leu Ser Phe Phe Leu Thr

1 5 10 15

Phe Ser Asn Pro Leu Gin Ala Leu Val He Glu Leu Leu Glu Glu He

20 25 30

Lys Thr Ser Pro His Lys Gly Thr Phe Lys Ala Lys Val Leu Asp Ser

35 40 45

Lys Glu Pro Arg Gin Val Leu Gly Val Tyr Asn He Ser Pro His Lys

50 55 60

Lys Leu Thr Leu Thr He Thr His He Ser Thr Ala He Val Tyr Gin 65 70 75 80

Pro Leu Asp Glu Lys Leu Ser Leu Glu Thr Thr Leu Ser Pro Asn Arg

85 90 95

Pro Thr He Pro Arg Asn Thr Gin He Val Phe Ser Ser Lys Glu Leu

100 105 110

Lys Glu Pro His Ser Asn Pro He Pro Ser 115 120

(2) INFORMATION FOR SEQ ID NO: 539:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 136 amino acids

(D) TOPOLOGY linear

(11) MOLECULE TYPE protein

(m) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE-

(A) ORGANISM Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...136

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 539 :

Lys Lys Phe His Thr Leu He Leu Pro Val Glu Trp Gly Thr Glu He

1 5 10 15

Val Leu Val Val Ser Gly Ser Leu Gin Asn He Val Arg Ser Phe Leu

20 25 30

Arg Arg He Ser Val Phe Phe He He Asp Phe He Asn Phe He Phe

35 40 45

Val He Asp Gin He He His Phe Phe Gly Asp Phe Phe He Phe Phe

50 55 60

Phe Met Leu Asn Leu Phe Tyr He Leu He Arg Leu He Asp Leu He 65 70 75 80

Val Leu Ser Gly Phe Ser Val Val Leu Val Arg Leu Gly Gin Phe Phe

85 90 95

Arg Leu He Phe Ala Cys Ala Gin His Ala Phe Asn Lys Val Asp He

100 105 110

Asp Lys Met Ser Asp Phe Arg Phe His Gin Leu Ser Phe Phe Lys Ser

115 120 125

Val Tyr Asn Leu Phe He Leu Ser 130 135

(2) INFORMATION FOR SEQ ID NO: 540:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 69 ammo acids

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...69

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 540:

Tyr Phe Leu Leu Ser Gly Glu Leu Arg Leu Ser Trp Trp Leu Val Ala 1 5 10 15 Arg Cys Lys Thr Leu Phe Val Leu Phe Cys Glu Gly Ser Ala Phe Ser

20 25 30

Ser Leu Leu He Ser Ser He Leu Phe Ser Leu Leu He Arg Ser Phe

35 40 45

Thr Ser Leu Val Thr Phe Ser Ser Ser Ser Ser Cys Ser He Phe Phe

50 55 60

He Ser Leu Leu Gly 65

(2) INFORMATION FOR SEQ ID NO: 541:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 243 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...243

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 541 :

Thr Leu Phe Lys Ser Ser Asp Lys Val Cys Asn Leu Met Arg Val He

1 5 10 15

He Lys Phe Met Leu He Ser Leu Lys Thr Phe Leu Lys He Leu Leu

20 25 30

Glu He Phe Leu Lys Thr Phe Gin Lys He Trp He Val Cys Val Val

35 40 45

He Trp Gly Leu Gly Cys Ser Phe Leu Asn Ala Asn Ser Val Gin Leu

50 55 60

Glu Glu Thr Leu Arg Arg Asn Pro Lys Asn Leu He Trp Gin His Phe 65 70 75 80

Lys Lys Lys Phe Lys Lys Ser Asn Thr He Pro Tyr Ala Pro Asn Ser

85 90 95

Arg Trp Lys Tyr Leu Gly Thr Ser He Gly He Leu Gly Val Ser Leu

100 105 110

Val He Gly He Val Gly Leu Tyr Leu Met Pro Glu Ser Val Thr Asn

115 120 125

Trp Asp Lys Glu Lys Phe Gly Val Lys Ser Trp Phe Glu Asn Val Arg

130 135 140

Met Gly Pro Lys Leu Asp Asn Asp Ser Phe He Phe Asn Glu He Leu 145 150 155 160

His Pro Tyr Phe Gly Ala Met Tyr Tyr Met Gin Pro Arg Met Ala Gly

165 170 175

Phe Ser Trp Met Thr Ser Ala Phe Phe Ser Phe He Thr Ser Thr Leu

180 185 190

Phe Trp Glu Tyr Gly Leu Glu Pro Phe Val Glu Val Pro Ser Trp Gin

195 200 205

Asp Leu Val He Thr Pro Leu Leu Gly Phe He Leu Gly Glu Gly Phe 210 215 220 Tyr Gin Leu Thr Pro He Ser Asn Ala Thr Lys Ala Ser Cys Leu Ala 225 230 235 240

Leu Tyr Phe

(2) INFORMATION FOR SEQ ID NO: 542:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 486 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...486

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 542:

Lys Lys Arg Lys Pro Met Phe Arg Lys Leu Ala Thr Ser Val Ser Leu

1 5 10 15

He Ser Leu Leu He Ser Asn Ala Leu Tyr Ala Lys Glu He Ser Glu

20 25 30

Ala Asp Lys Val He Lys Ala Thr Lys Glu Thr Lys Glu Thr Lys Lys

35 40 45

Glu Ala Lys Arg Leu Lys Lys Glu Ala Lys Gin Arg Gin Gin He Pro

50 55 60

Asp Asn Lys Lys Pro Gin Tyr Val Ser Val Asp Asp Thr Lys Thr Gin 65 70 75 80

Ala Leu Phe Asp He Tyr Asp Thr Leu Asn Val Asn Asp Lys Ser Phe

85 90 95

Gly Asp Trp Phe Gly Asn Ser Ala Leu Lys Asn Lys Thr Tyr Leu Tyr

100 105 110

Ala Met Asp Leu Leu Asp Tyr Asn Asn Tyr Leu Ser He Glu Asn Pro

115 120 125

He He Lys Thr Arg Ala Met Gly Thr Tyr Ala Asp Leu He He He

130 135 140

Thr Gly Ser Leu Glu Gin Val Asn Gly Tyr Tyr Asn He Leu Lys Ala 145 150 155 160

Leu Asn Lys Arg Asn Ala Lys Phe Val Leu Lys He Asn Asp Lys He

165 170 175

Pro Tyr Ala Gin Ala Thr Phe Leu Arg Val Pro Lys Arg Ser Asp Pro

180 185 190

Asn Ala His Thr Leu Asp Lys Gly Ala Ser He Asp Glu Ser Lys Leu

195 200 205

Phe Glu Gin Gin Lys Lys Met Tyr Phe Asn Tyr Ala Asn Asp Val He

210 215 220

Cys Arg Pro Asn Asp Glu Val Cys Ser Pro Leu Arg Asp Glu Met Val 225 230 235 240

Ala Met Pro Thr Asn Asp Ser Val Thr Gin Lys Pro Asn He He Ala 245 250 255 Pro Tyr Ser" Leu Tyr Arg Leu Lys Glu Thr Asn Asn Ala Asn Glu Ala

260 265 270

Gin Pro Ser Pro Tyr Ala Thr Gin Thr Ala Pro Glu Asn Ser Lys Glu

275 280 285

Lys Leu He Glu Glu Leu He Ala Asn Ser Gin Leu He Ala Asn Glu

290 295 300

Glu Glu Arg Glu Lys Lys Leu Leu Ala Glu Lys Glu Lys Gin Glu Thr 305 310 315 320

Glu Leu Ala Lys Tyr Lys Leu Lys Asp Leu Glu Asn Gin Lys Lys Leu

325 330 335

Lys Ala Leu Glu Ala Glu Leu Lys Lys Lys Asn Thr Lys Lys Pro Arg

340 345 350

Val Val Glu Val Pro He Pro Pro Lys Thr Ser Asp Ser Asp Glu Thr

355 360 365

Met Arg Val He Lys Glu Lys Glu Asn Tyr Asn Gly Leu Leu Val Asp

370 375 380

Lys Glu Thr Thr He Lys Arg Ser Tyr Lys Gly Thr Leu He Ser Glu 385 390 395 400

Asn Ser Tyr Ser Lys Lys Thr Pro He Asn Leu Glu Asp Leu Arg Ser

405 410 415

Leu Glu Glu Glu He Lys Ser Tyr Tyr Val Lys Ser Asn Gly Leu Cys

420 425 430

Tyr Ala Asn Gly He Asn Leu Tyr Val Lys He Lys Asn Asp Pro Tyr

435 440 445

Lys Glu Gly Met Leu Cys Gly Tyr Glu Ser Val Gin Lys Leu Leu Ser

450 455 460

Pro Leu Arg Asp Lys Leu Lys Tyr Asp Lys Gin Lys Leu Gin Lys Ala 465 470 475 480

Leu Leu Lys Asp Leu Lys 485

(2) INFORMATION FOR SEQ ID NO: 543:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 101 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...101

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 543 :

Val Val Gly Thr Met Glu Asp Phe Leu Tyr Asn Thr Leu Tyr Phe He

1 5 10 15

Glu Asp Tyr Lys Leu Val Val He Phe Ser Phe He Gly Leu He Ala

20 25 30

Leu Phe Phe Leu Tyr Lys Phe He Lys Thr Gin Lys Lys Val Phe Lys

35 40 45 Asp Lys Ala Asn Gin Pro Gin Lys Lys Lys Ser Phe Lys Glu He He

50 55 60

He Asp Gly Leu Lys Glu Arg Val Lys Thr Phe Gly Phe Trp Leu Pro 65 70 75 80

Ser Tyr Thr He Thr He Leu Phe Phe Tyr His He Arg Val He Phe

85 90 95

Leu Asp Ser Leu Arg 100

(2) INFORMATION FOR SEQ ID NO: 544:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 293 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...293

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 544 :

Arg Met Ala Gin He Val Lys Gly Ser Asp Met Phe Glu Asp Phe Tyr

1 5 10 15

Arg Thr Thr Leu Ser Phe Leu Arg Ser Leu Leu Leu Leu Leu Gly Leu

20 25 30

Leu Leu Pro Phe Ser Leu Cys He Ala Asp Glu Tyr He Ser He Ser

35 40 45

Asp Asp Trp Asp Glu Arg Ala Arg Asn Gin Trp Asp Glu Thr Ala Arg

50 55 60

Asn His Lys Thr Tyr Tyr Phe Glu Asn Gly Leu Asp His Phe Asn Gin 65 70 75 80

Gly Gin Tyr Lys Gin Ala Phe Lys Asp Phe Lys Leu Ala Gin Glu Tyr

85 90 95

Ser He Gly Leu Gly Asn Val Tyr Leu Ala Lys Met Tyr Leu Glu Gly

100 105 110

Lys Gly Val Lys Val Asp Tyr Lys Lys Ala Gin Phe Tyr Ala Gin Asn

115 120 125

Ala He Lys Gly Tyr Gly Ser Gly Leu Leu Gly Gly Ala Leu He Leu

130 135 140

Gly Arg Met Gin Ala Glu Gly Leu Gly Met Lys Lys Asp Leu Lys Gin 145 150 155 160

Ala Leu Lys Thr Tyr Arg His Val Val Arg Met Phe Ser Asn Lys Ser

165 170 175

Ala Asn Phe Ala Asn Lys Phe Gly Ser Asn Leu Ala Glu Phe Thr Ser

180 185 190

Met Leu He Gly Ser Arg Phe He Asp Leu Ser Gly Leu Ser Ala Asn

195 200 205

Pro He Lys Phe Gly Asn Lys Phe Gly He Leu Val Lys Lys Ala Leu 210 215 220 Gin He Lys Asp Asn Thr Leu Ser Trp Glu Asp He Ala Glu He Ser 225 230 235 240

Ser Asn He He Leu Leu Lys Gin Gin Met Gly Glu He Leu Tyr Arg

245 250 255

He Gly He Ala Tyr Lys Glu Gly Leu Gly Thr Arg Lys Lys Lys Asp

260 265 270

Arg Ala Lys Lys Phe Leu Gin Lys Ser Ala Glu Phe Gly Tyr Glu Lys

275 280 285

Ala Met Glu Ala Leu 290

(2) INFORMATION FOR SEQ ID NO: 545:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 81 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...81

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 545 :

Asp Phe His Asp Phe Cys Ala Asn He His His Arg He Arg Trp Arg

1 5 10 15

His Arg His He Ala Ser Leu Leu Ser Arg Ser Met Pro Lys He His

20 25 30

Ala Val Phe Lys Ala Phe He Pro He Pro Phe Ala Leu Phe Ala He

35 40 45

His Phe Val Val Leu Gly He Gly Ser Val Phe Asn Leu Asn Arg He

50 55 60

Lys Asp Lys Lys Phe He Leu Arg Ala Lys He Ser His He Ala Gin 65 70 75 80

Ala

(2) INFORMATION FOR SEQ ID NO: 546:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 104 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori ( ix ) FEATURE :

(A) NAME/KEY: misc_feature

(B) LOCATION 1...104

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 546 :

Lys Ala Met Leu Ser Ser Thr Asn Asp He Arg Tyr Gin Asn Pro Lys

1 5 10 15

Asn Lys Ala Leu Lys Gly Glu He Leu Ala Asn Leu Lys Phe He Lys

20 25 30

Lys Leu Leu Gly He Gly Cys Lys Asp Pro Ser Ala Tyr Val Gin Leu

35 40 45

Gly Val Ser Lys Ser Glu Lys Gin Glu He Glu Asn Lys He Glu Glu

50 55 60

Arg Lys Arg Ala Lys Glu Gin Lys Asp Phe Leu Lys Ala Asp Ser. He 65 70 75 80

Arg Glu Glu Leu Leu Gin Gin Lys He Ala Leu Met Asp Thr Pro Gin

85 90 95

Gly Thr He Trp Glu Lys Leu Phe 100

(2) INFORMATION FOR SEQ ID NO: 547:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 529 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...529

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 547 :

Met Arg Lys Val He He Met Asn Gly Tyr Leu Arg Val Lys Thr Pro

1 5 10 15

Tyr Phe Leu Ala Ser Val Val Leu Thr Phe Trp Thr Phe Asn Ser Phe

20 25 30

Met Ser Ala Lys Asp Lys His His Phe Leu Lys Lys Val Thr Thr Thr

35 40 45

Glu Gin Lys Phe Ser Ser Ser Ala Pro He Ser Trp Gin Ser Glu Glu

50 55 60

Val Arg Asn Ser Thr Ser Ser Arg Thr Val He Ser Asn Lys Glu Leu 65 70 75 80

Lys Lys Thr Gly Asn Leu Asn He Glu Asn Ala Leu Gin Asn Val Pro

85 90 95

Gly He Gin He Arg Asp Ala Thr Gly Thr Gly Val Leu Pro Lys He

100 105 110

Ser Val Arg Gly Phe Gly Gly Gly Gly Asn Gly His Ser Asn Thr Asn 115 120 125

Met He Leu Val Asn Gly He Pro He Tyr Gly Ala Pro Tyr Ser Asn

130 135 140

He Glu Leu Ala He Phe Pro Val Thr Phe Gin Ser Val Asp Arg He 145 150 155 160

Asp Val He Lys Gly Gly Thr Ser Val Gin Tyr Gly Pro Asn Thr Phe

165 170 175

Gly Gly Val Val Asn Val He Thr Lys Glu He Pro Lys Glu Trp Glu

180 185 190

Asn Gin Ala Ala Glu Arg He Thr Phe Trp Gly Arg Ser Ser Asn Gly

195 200 205

Asn Phe Val Asp Pro Lys Glu Lys Gly Lys Pro Leu Ala Gin Thr Leu

210 215 220

Gly Asn Gin Met Leu Phe Asn Thr Tyr Gly Arg Thr Ala Gly Met Leu 225 230 235 240

Gly Lys Tyr He Gly He Ser Ala Gin Gly Asn Trp He Asn Gly Gin

245 250 255

Gly Phe Arg Gin Asn Ser Pro Thr Lys Val Gin Asn Tyr Leu Leu Asp

260 265 270

Ala He Tyr Lys He Asn Ala Thr Asn Thr Phe Lys Ala Tyr Tyr Gin

275 280 285

Tyr Tyr Gin Tyr Asn Ser Tyr His Pro Gly Thr Leu Ser Ala Gin Asp

290 295 300

Tyr Ala Tyr Asn Arg Phe He Asn Glu Arg Pro Asp Asn Gin Asp Gly 305 310 315 320

Gly Arg Ala Lys Arg Phe Gly He Val Tyr Gin Asn Tyr Phe Gly Asp

325 330 335

Pro Asp Arg Lys Val Gly Gly Asp Phe Lys Phe Thr Tyr Phe Thr His

340 345 350

Asp Met Ser Arg Asp Phe Gly Phe Ser Asn Gin Tyr Gin Ser Val Tyr

355 360 365

Met Ser Gly Gin Asn Lys He Leu Pro Phe Lys Gly Lys Gly Glu He

370 375 380

Ser Ala Lys Asn Pro Asn Cys Gly Leu Tyr Ser Tyr Ser Asp Thr Asn 385 390 395 400

Ser Pro Cys Trp Gin Phe Phe Asp Asn He Arg Arg Ser Val Val Asn

405 410 415

Ala Phe Glu Pro Lys Leu Asn Leu He Val Asn Thr Gly Lys Val Lys

420 425 430

Gin Thr Phe Asn Met Gly Met Arg Phe Leu Thr Glu Asp Leu Tyr Arg

435 440 445

Arg Ser Thr Thr Arg Lys Asn Pro Ser Met Pro Asn Asn Gly Ser Gly

450 455 460

Phe Asp Ala Gly Thr Ser Leu Asn Asn Phe Asn Asn Tyr Thr Ala Val 465 470 475 480

Tyr Ala Ser Asp Glu He Asn Phe Asn Asn Gly Met Leu Thr He Thr

485 490 495

Pro Gly Leu Arg Tyr Thr Phe Leu Asn Tyr Glu Lys Lys Asp Ala Pro

500 505 510

Pro Phe Lys Val Gly Gin Thr Pro Lys Thr Thr Lys Glu Arg Tyr Asn

515 520 525

Gin

,'2) INFORMATION FOR SEQ ID NO: 548: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 194 ammo acids

(D) TOPOLOGY, linear

(n) MOLECULE TYPE, protein

(m) HYPOTHETICAL. YES

(vi ) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...194

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 548 :

Arg Val Gly Phe Arg Ser Phe Ser Gly Gly His Cys Ala Glu He Phe

1 5 10 15

Arg Phe Asn Pro His Pro Met Ala Phe Cys Ala Arg Gin Lys Pro Leu

20 25 30

Lys Glu He Met Arg Phe Phe He Leu Phe Phe Met Gly Met Leu Gly

35 40 45

Val Gly Phe Ser Gin Thr Glu Leu Asp Leu Lys Asp Leu Glu Lys Lys

50 55 60

Pro Ala Gly He Val Arg Asp Tyr Tyr Leu Trp Arg Tyr He Ser Asp 65 70 75 80

Lys Lys Thr Ser Leu Glu Asn Ala Lys Lys Ala Tyr Glu Leu Thr Gin

85 90 95

Asn Lys Asn Ser Ala Leu Gin Lys Ala Met Gin Glu Lys Gly Val Glu

100 105 110

Asn Ser Asp Lys Ser Pro Asp Ala Lys Met Pro Glu Asp He Tyr Cys

115 120 125

Lys Gin He Thr Leu Glu Ser Met Leu Glu Thr Thr Asp Ala Phe Gin

130 135 140

Ala Ser Cys He Ala He Ala Leu Lys Ser Lys He Arg Asp Phe Asp 145 150 155 160

Lys He Pro He Gin Thr Phe Lys Pro Leu Gin Glu Lys He Lys Glu

165 170 175

Ala Tyr Pro He Leu Tyr Glu Glu Leu Glu He Leu Gin Ser Lys Asn

180 185 190

Val Ser

(2) INFORMATION FOR SEQ ID NO: 549:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 206 ammo acids

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori ( ix ) FEATURE :

(A) NAME/KEY: misc_feature

(B) LOCATION 1...206

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 549 :

His Ala Leu Tyr Ser Pro He Lys He Ala Phe Glu Lys Ala Leu Lys

1 5 10 15

Asn Ala Lys Glu Ser Val Phe He Ala Ser Ser Tyr Phe He Pro Gly

20 25 30

Lys Lys He Met Lys He Phe Lys Asn Gin He Ser Lys Gly He Glu

35 40 45

Leu Asn He Leu Thr Asn Ser Leu Ser Ser Thr Asp Ala He Val Val

50 55 60

Tyr Gly Ala Trp Glu Arg Tyr Arg Asn Lys Leu Val Arg Met Gly Ala 65 70 75 80

Asn Val Tyr Glu He Arg Asn Asp Phe Phe Asn Arg Gin He Lys Gly

85 90 95

Arg Phe Ser Thr Lys His Ser Leu His Gly Lys Thr He Val Phe Asp

100 105 110

Asp Ala Leu Thr Leu Leu Gly Ser Phe Asn He Asp Pro Arg Ser Ala

115 120 125

Tyr He Asn Thr Glu Ser Ala Val Leu Phe Asp Asn Pro Ser Phe Ala

130 135 140

Lys Arg Val Arg Leu Ser Leu Lys Asp His Ala Gin Gin Ser Trp His 145 150 155 160

Leu Val Leu Tyr Arg His Arg Val He Trp Glu Ala Thr Glu Glu Gly

165 170 175

He Leu He His Glu Lys Asn Ser Pro Asp Thr Ser Phe Phe Leu Arg

180 185 190

Leu He Lys Glu Trp Ser Lys Val Leu Pro Glu Arg Glu Leu 195 200 205

(2) INFORMATION FOR SEQ ID NO: 550:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 442 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...442

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 550 :

Gly Lys He Lys Gly Val Met Met Lys Phe Phe Leu Leu Lys Lys Phe

1 5 10 15

Ser Glu Phe Leu Asn Thr Gin Thr His Phe Asn Leu Lys Arg Leu Asn 20 25 30

Ala Ser Ser Phe Leu Leu Glu Thr Phe Ser Lys Glu Lys His Ala Phe

35 40 45

Val Val Asp Leu Ser Ala Pro Tyr He Gly Leu Ser Lys Lys Pro Pro

50 55 60

Glu Ser Val Leu Lys Asn Thr Leu Ala Leu Asp Phe Cys Leu Asn Lys 65 70 75 80

Phe Thr Lys Asn Ala Lys He Leu Gin Ala Asn Val He Asp Asn Asp

85 90 95

Arg He Leu Glu He Lys Gly Ala Lys Asp Leu Ala Tyr Lys Ser Glu

100 105 110

Thr Phe He Leu Arg Leu Glu Met He Pro Lys Lys Ala Asn Leu Met

115 120 125

He Leu Asp Gin Glu Lys Cys Val He Glu Ala Phe Arg Phe Asn Asp

130 135 140

Arg Val Ala Lys Asn Asp He Leu Gly Ala Leu Pro Pro Asn He Tyr 145 150 155 160

Glu His Gin Glu Glu Asp Leu Asp Phe Lys Gly Leu Leu Asp He Leu

165 170 175

Glu Lys Asp Phe Leu Ser Tyr Gin His Lys Glu Leu Glu His Lys Lys

180 185 190

Asn Gin He He Lys Arg Leu Asn Ala Gin Lys Glu Arg Leu Lys Glu

195 200 205

Lys Leu Glu Lys Leu Glu Asp Pro Lys Thr Leu Gin Leu Glu Ala Lys

210 215 220

Glu Leu Gin Thr Gin Ala Ser Leu Leu Leu Thr Tyr Gin His Leu He 225 230 235 240

Asn Arg Arg Glu Asn Arg Val He Leu Lys Asp Phe Glu Asp Lys Glu

245 250 255

Cys Met He Glu He Asp Lys Ser Met Pro Leu Asn Ala Phe He Asn

260 265 270

Lys Lys Phe Thr Leu Ser Lys Lys Lys Lys Gin Lys Ser Gin Phe Leu

275 280 285

Tyr Leu Glu Glu Glu Asn Leu Lys Glu Lys He Ala Phe Lys Glu Asn

290 295 300

Gin He Asn Tyr Val Arg Asp Ala Ala Glu Glu Ser Val Leu Glu Met 305 310 315 320

Phe Met Pro Val Lys Asn Ser Lys He Lys Arg Pro Met Asn Gly Tyr

325 330 335

Glu Val Leu Tyr Tyr Lys Asp Phe Lys He Gly Leu Gly Lys Asn Gin

340 345 350

Lys Glu Asn He Lys Leu Leu Gin Asp Ala Arg Ala Asn Asp Leu Trp

355 360 365

Met His Val Arg Asp He Pro Gly Ser His Leu He Val Phe Cys Gin

370 375 380

Lys Asn Thr Pro Lys Asp Glu Val He Met Glu Leu Ala Lys Met Leu 385 390 395 400

He Lys Met Gin Lys Asp Ala Phe Asn Gly Tyr Glu He Asp Tyr Thr

405 410 415

Gin Arg Lys Phe Val Lys He He Lys Gly Ala His Val He Tyr Ser

420 425 430

Lys Tyr Arg Thr He Ser Leu Lys Asp Thr 435 440

(2) INFORMATION FOR SEQ ID NO: 551:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 293 ammo acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(m) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

( ix ) FEATURE :

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...293

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 551 :

Gly Phe Met Met He Phe He Asp Ala Cys Phe Arg Lys Glu Thr Pro

1 5 10 15

Tyr Thr Pro He Trp Met Met Arg Gin Ala Gly Arg Tyr Leu Ser Glu

20 25 30

Tyr Gin Glu Ser Arg Lys Lys Ala Gly Ser Leu Leu Glu Leu Cys Lys

35 40 45

Asn Ser Asp Leu Ala Thr Glu Val Thr Leu Gin Pro Val Glu He Leu

50 55 60

Gly Val Asp Ala Ala He Leu Phe Ser Asp He Leu Val Val Pro Leu 65 70 75 80

Glu Met Gly Leu Asn Leu Glu Phe He Pro Lys Lys Gly Pro His Phe

85 90 95

Leu Glu Thr He Thr Asp Leu Lys Ser Val Glu Ser Leu Lys Val Gly

100 105 110

Val Tyr Lys Gin Leu Asn Tyr Val Tyr Asp Thr He Ser Gin Thr Arg

115 120 125 ^■

Gin Lys Leu Ser Lys Glu Lys Ala Leu He Gly Phe Cys Gly Ser Pro

130 135 140

Trp Thr Leu Ala Thr Tyr Met He Glu Gly Glu Gly Ser Lys Ser Tyr 145 150 155 160

Ala Lys Ser Lys Lys Met Leu Tyr Ser Glu Pro Glu Val Leu Lys Ala

165 170 175

Leu Leu Glu Lys Leu Ser Leu Glu Leu He Glu Tyr Leu Ser Leu Gin

180 185 190

He Gin Ala Gly Val Asn Ala Val Met He Phe Asp Ser Trp Ala Ser

195 200 205

Ala Leu Glu Lys Glu Ala Tyr Leu Glu Phe Ser Trp Asp Tyr Leu Lys

210 215 220

Lys He Ser Lys Glu Leu Lys Lys Arg Tyr Ala His He Pro Val He 225 230 235 240

Leu Phe Pro Lys Gly He Gly Ala Tyr Leu Asp Ser He Asp Gly Glu

245 250 255

Phe Asp Leu Phe Gly Leu Asp Gly Gly Thr Pro Leu Thr Ala Ala Lys

260 265 270

Lys Lys Leu Ala Val He He Phe Leu Gin Gly He Tyr Asn Pro Pro

275 280 285

Ala Phe Met He Lys 290

(2) INFORMATION FOR SEQ ID NO: 552: ( ) SEQUENCE CHARACTERISTICS

(A) LENGTH: 192 ammo acids

(B) TYPE ammo acid (D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(m) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...192

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 552 :

Arg Val Phe Leu Thr Lys Lys Phe Met Ser Trp Met Val Val He Gly

1 5 10 15

Ala Leu He Cys Val Leu Leu Gly Val Phe He Phe Phe Thr Ser Met

20 25 30

Ser Val Lys Lys Ser Leu Thr Ala Tyr Leu Asn Ala Tyr Leu Glu Gin

35 40 45

Arg Pro Asn He Glu Gly Met Gly He He Gly Val Pro Phe Lys Cys

50 55 60

Glu Arg Phe Phe Lys He Ala Cys Val Ser Lys Glu Leu Arg Phe Leu 65 70 75 80

Asn Pro Gin Asn Ser Pro He Met Asp Phe Lys Asn Leu Glu He Lys

85 90 95

Leu His Ser Leu Asp Lys Ser Ser Leu Thr Leu Ser He His Ser Gin

100 105 110

He Gin Ser Pro He Leu Glu Gin Ser He Gin Gin Lys He Ser Gin

115 120 125

He Pro Leu Lys Asn Leu Asn Ala Leu Leu Glu Lys Phe Lys Pro Thr

130 135 140

Arg Leu Asn Cys Ser Leu Thr Phe Asn Ala Leu Asp Glu Lys Thr Leu 145 150 155 160

Asn Asp Asn Leu Lys Cys Asp Leu Thr Asn Ala Glu Asn Leu Leu Leu

165 170 175

His Phe Phe Ser Arg Gly Phe Asn Gly Gly Ala Arg Lys Ser Leu Pro 180 185 190

(2) INFORMATION FOR SEQ ID NO: 553:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 370 ammo acids

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori ( ix ) FEATURE :

(A) NAME/KEY: misc_feature

(B) LOCATION 1...370

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 553:

Gin Asp Gin Pro Met Gin Phe Gin Lys Thr Leu Leu Ser Leu Ser Leu

1 5 10 15

Leu Phe Leu Ser Tyr Cys He Ala Glu Glu Asn Gly Ala Tyr Ala Ser

20 25 30

Val Gly Phe Glu Tyr Ser He Ser His Ala Val Glu His Asn Asn Pro

35 40 45

Phe Leu Asn Gin Glu Arg He Gin Thr He Ser Asn Ala Gin Asn Lys

50 55 60

He Tyr Lys Leu Asn Gin Val Lys Asn Glu He Thr Asn Met Pro Asn 65 70 75 80

Thr Phe Asn Tyr He Asn Asn Ala Leu Lys Asn Asn Ala Lys Leu Thr

85 90 95

Pro Thr Glu Lys Gin Ala Glu Thr Tyr Tyr Leu Gin Ser Thr Leu Gin

100 105 110

Asn He Glu Lys He Val Met Leu Ser Gly Gly Val Ala Ser Asn Pro

115 120 125

Lys Leu Ala Gin Ala Leu Glu Lys Met Gin Glu Pro He Thr Asn Pro

130 135 140

Leu Glu Leu Val Glu Asn Leu Lys Asn Leu Glu Leu Gin Phe Ser Gin 145 150 155 160

Ser Gin Asn Ser Met Leu Ser Ser Leu Ser Ser Gin He Ala Gin He

165 170 175

Ser Asn Ser Leu Asn Ala Leu Asp Pro Ser Ser Tyr Ser Lys Asn Val

180 185 190

Ser Ser Met Tyr Gly Val Gly Leu Ser Val Gly Tyr Lys His Phe Phe

195 200 205

Thr Lys Lys Lys Asn Gin Gly Phe Arg Tyr Tyr Leu Phe Tyr Asp Tyr

210 215 220

Gly Tyr Thr Asn Phe Gly Phe Val Gly Asn Gly Phe Asp Gly Leu Gly 225 230 235 240

Lys Met Asn Asn His Leu Tyr Gly Leu Gly He Asp Tyr Leu Phe Asn

245 250 255

Phe He Asp Asn Ala Gin Lys His Ser Ser Val Gly Phe Tyr Val Gly

260 265 270

Phe Ala Leu Ala Gly Ser Ser Trp Val Gly Ser Gly Leu Gly Met Trp

275 280 285

Val Ser Gin Met Asp Phe He Asn Asn Tyr Leu Thr Asp Tyr Arg Ala

290 295 300

Lys Met His Thr Ser Phe Phe Gin He Pro Leu Asn Phe Gly Val Arg 305 310 315 320

Val Asn Val Asp Arg His Asn Gly Phe Glu Met Gly Leu Lys He Pro

325 330 335

Leu Ala Val Asn Ser Phe Tyr Glu Thr His Gly Lys Gly Leu Asn Ala

340 345 350

Ser Leu Phe Phe Lys Arg Leu Val Met Phe Asn Val Ser Tyr Val Tyr

355 360 365

Ser Phe 370

(2) INFORMATION FOR SEQ ID NO: 554: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 243 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_£eature

(B) LOCATION 1...243

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 554 :

Glu Pro Met Pro Met Gly Lys Ala Leu Lys Glu Tyr Gin He Lys Lys

1 5 10 15

Thr Arg Asp Val Gly He Gly Ala Lys Asn Ser Glu He Met Thr Ser

20 25 30

Ala Gin Val Glu Leu Gly Lys Met Leu Tyr Phe Asp Pro Arg He Ser

35 40 45

Thr Ser Tyr Leu Val Ser Cys Asn Thr Cys His Asn Leu Gly Leu Gly

50 55 60

Gly Val Asp Leu He Pro Ser Ala He Gly Ser Gin Trp Lys Lys Asn 65 70 75 80

Pro His Leu Leu Ser Ser Pro Thr Val Tyr Asn Ser Val Phe Asn Asp

85 90 95

Val Gin Phe Trp Asp Gly Arg Val Thr His Leu Asn Glu Gin Ala Gin

100 105 110

Gly Pro He Gin Ser Ser Phe Glu Met Gly Ala Asp Pro Lys Val Val

115 120 125

Val Glu Lys He Asn Ser He Pro Gly Tyr Val Lys Leu Phe Arg Lys

130 135 140

Ala Tyr Gly Ser Lys Val Lys He Asp Phe Lys Leu He Ala Asp Ser 145 150 155 160

He Ala Met Phe Glu Ala Thr Leu He Thr Pro Ser Arg Tyr Asp Asp

165 170 175

Phe Leu Arg Gly Asn Pro Lys Ala Leu Ser Lys Ala Glu Lys Glu Gly

180 185 190

Leu Asp Leu Phe He Ser Lys Gly Cys Val Ala Cys His Asn Gly He

195 200 205

Asn Leu Gly Gly Thr Met Gin Pro Phe Gly Val Val Lys Pro Tyr Lys

210 215 220

Phe Ala Asn Val Gly Asp Phe Lys Gly Asp Lys Asn Gly Leu Val Lys 225 230 235 240

Val Pro Thr

(2) INFORMATION FOR SEQ ID NO: 555:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 234 amino acids

(B) TYPE: amino acid (D) TOPOLOGY, linear

(11) MOLECULE TYPE: protein

(m) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...234

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 555 :

Asn Asp Phe Trp Arg Lys Glu He Thr Met Arg Ala Thr Ala He Lys

1 5 10 15

He Phe Ser Phe Ser Ser Ala Leu Ala Leu Leu Leu Gin Gly Cys Leu

20 25 30

Ser He Asn Leu Lys Gin Met Leu Pro Glu He Arg Thr Tyr Asp Leu

35 40 45

Asn Ala Ser Ser Phe Glu Met Thr Gin Cys Pro Lys Pro Leu Thr Glu

50 55 60

Val Arg Leu He He He Leu Ser Ala Asp Leu Phe Asn Thr Lys Glu 65 70 75 80

He Val Phe Lys Ala Gin Asp Gly Gin He Thr His Gly Lys His Gin

85 90 95

Lys Trp He Asp Leu Pro Arg Asn Met Leu Lys Thr Met Phe Met Gin

100 105 110

Glu Ala Gin Lys Ala Cys Leu Gly Val Ala Leu Pro Pro Tyr Gly Ala

115 120 125

Gly Ala Pro Thr Tyr Ala Val Arg Phe Thr He Leu Ser Phe Ser Leu

130 135 140

Leu Glu Lys Glu Asn Ser Thr Tyr Arg Ala Glu Phe Ala Leu Gly Tyr 145 150 155 160

Asp He Ser Val Lys Gly Asp Ser His Ser Gly Val He He Lys His

165 170 175

Glu Asn He Ser Ser Leu Glu Asn Lys Thr Thr Lys Thr Ser Lys Asn

180 185 190

Gly Ser Gin Asp Phe Gin Glu Ser Ala He Gin Ser Leu Gin His Val

195 200 205

Ser Thr Gin Ala Met Gin Glu Ala He Ser Leu He Lys Lys Ala Val

210 215 220

Glu Ala Gin Ser Val Ser Pro Leu Lys Lys 225 230

(2) INFORMATION FOR SEQ ID NO: 556:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 283 ammo acids

(D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE:

(A) ORGANISM- Helicobacter pylori

(ix) FEATURE.

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...283

( xi ) SEQUENCE DESCRIPTION . SEQ ID NO : 556 :

Arg Gin Phe He Gin Phe Asn Thr Arg Arg Glu He Leu Glu Arg Hi s

1 5 10 15

Val Asn Tyr Thr Leu He Gly Gly Leu Phe Phe Leu Cys Leu Val Cys

20 25 30

Met Val Gly Phe He Leu Trp Leu Gly His Leu Gly Leu Asp Asp Gly

35 40 45

Lys Tyr Tyr Glu Tyr Val Val Tyr Thr Asp Lys Asp Leu Gly Gly He

50 55 60

Ala Thr Asn Ser Pro He Asn Tyr Lys Gly He Gin Val Gly Asn Val 65 70 75 80

He Lys Val Gly Phe Ala Lys Asp Lys Val Gly Val Val Arg Leu Asp

85 90 95

Leu Met He Lys Ser Ser Val Lys He Arg Lys Asp Ser Lys Val Ala

100 105 110

Val Ser Ser Arg Gly Phe Met Gly Leu Lys Phe Leu Ala Leu Glu Gin

115 120 125

Ser His Asn Glu Glu Phe Tyr Gly Ser Gly Asp Lys Gly Glu Arg He

130 135 140

Leu He Phe Lys Glu Gly Leu Met Asp Arg Leu Ser Gly Asp Ala Asn 145 150 155 160

Gin Val Val Gin Glu Val Met Lys Ala He Arg Asn Val Asn Arg He

165 170 175

Leu Asp Asp Glu Asn Val Glu Lys Phe Lys His He Leu Ala Ser Val

180 185 190

Asp Asp Leu He Ala Asn Leu Asp Ser Arg Lys Thr Gin Phe Asp Ser

195 200 205

Leu He Asn Asn Ala Asn Asn Leu Val Ser Asn Val Asn Asn Val Ala

210 215 220

Leu Asp Val Asp Lys Arg Val Lys Gin Gly Gin Tyr Asp Phe Lys Ala 225 230 235 240

Met Phe Thr Pro Leu He Met Gin Ala Gin Leu Ser Leu Arg Asn He

245 250 255

Asp Asn Phe Val Glu Lys Gly Ser Ala Leu He Asp Lys Phe Asp Ala

260 265 270

Asn Pro Tyr Lys Thr He Phe Gly Glu Arg Lys 275 280

(2) INFORMATION FOR SEQ ID NO: 557:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 150 ammo acids

(D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...150

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 557 :

Ser Ser Ser Gin Ser He Ala Leu Leu He Gly Leu Trp Phe Gly Phe

1 5 10 15

Gin Lys Arg He Ala Leu Gly Val Trp Phe Phe Phe Ser He Leu Leu

20 25 30

Gly Glu Phe Thr Leu Lys Ser Leu Lys Leu Leu Val Ala Arg Pro Arg

35 40 45

Pro Val Thr Asn Gly Glu Leu Val Phe Ala His Gly Phe Ser Phe Pro

50 55 60

Ser Gly His Ala Leu Ala Ser Ala Leu Phe Tyr Gly Ser Leu Ala Leu 65 70 75 80

Leu Leu Cys Tyr Ser Asn Ala Asn Asn Arg He Lys Thr He Gly Ala

85 90 95

He He Leu Leu Phe Trp He Phe Leu Met Ala Tyr Asp Arg Val Tyr

100 105 110

Leu Gly Val His Tyr Pro Ser Asp Val Leu Gly Gly Phe Leu Leu Gly

115 120 125

He Ala Trp Ser Cys Cys Ser Leu Ala Leu Tyr Leu Gly Phe Leu Lys

130 135 140

Arg Pro Tyr Lys Ala Ala 145 150

(2) INFORMATION FOR SEQ ID NO: 558:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 73 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...73

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 558:

Met Met Asp Leu Glu Ser Leu Arg Gly Phe Ala Tyr Ala Phe Phe Thr

1 5 10 15

He Leu Phe Thr Leu Phe Leu Tyr Ala Tyr He Phe Ser Met Tyr Arg

20 25 30

Lys Gin Lys Lys Gly He Val Asp Tyr Glu Arg Tyr Gly Tyr Leu Ala

35 40 45

Leu Asn Asp Ala Leu Glu Asp Glu Leu He Glu Pro Arg His Lys Glu 50 55 60

Val His Asp Lys Gly He Lys Glu Ser 65 70

(2) INFORMATION FOR SEQ ID NO.559:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 100 ammo acids

(B) TYPE: ammo acid (D) TOPOLOGY- linear

(n) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi ) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...100

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 559 :

Gly Asn Leu Met Gly Gin Thr Lys Glu He He Thr Thr Leu Leu Pro

1 5 10 15

Leu Leu Val Leu Phe Leu He Phe Tyr Phe Leu He Val Arg Pro Gin

20 25 30

Arg Gin Gin Gin Lys Lys His Lys Glu Met He Glu Gly Leu Thr Lys

35 40 45

Gly Asp Lys He Val Thr Gin Gly Gly Leu He Val Glu Val Leu Lys

50 55 60

Ala Glu Ala Asn Phe Phe Ser Val Lys Leu Asn Asp Asp Thr Thr Ala 65 70 75 80

Lys Leu Ser Lys Asn Tyr Val Ala Phe Lys Leu Asp Glu Glu Thr Thr

85 90 95

Pro Asn Asn Asn 100

(2) INFORMATION FOR SEQ ID NO: 560:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 159 ammo acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi ) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...159 ( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 560 :

Met Lys Leu Phe Asn Pro Arg Leu He Val Phe He Phe Al a Leu Leu

1 5 10 15

Leu Gly Val Gly Phe Ser Val Pro Ser Leu Leu Glu Thr Lys Gly Pro

20 25 30

Lys He Thr Leu Gly Leu Asp Leu Arg Gly Gly Leu Asn Met Leu Leu

35 40 45

Gly Val Gin Thr Asp Glu Ala Leu Lys Asn Lys Tyr Leu Ser Leu Ala

50 55 60

Ser Ala Leu Glu Tyr Asn Ala Lys Lys Gin Asn He Leu Leu Lys Asp 65 70 75 80

He Lys Ser Ser Leu Glu Gly He Ser Phe Glu Leu Leu Asp Glu Asp

85 90 95

Glu Ala Lys Lys Leu Asp Ala Leu Leu Leu Glu Leu Gin Gly His Ser

100 105 110

Gin Phe Glu He Lys Lys Glu Ala Glu Phe Tyr Ser Val Lys Leu Thr

115 120 125

Pro Leu Glu Gin Glu Glu Leu Arg Lys Asn Thr He Leu Gin Val He

130 135 140

Gly He He Arg He Arg Leu Asp His Leu Ala Trp Gin Ser Leu 145 150 155

(2) INFORMATION FOR SEQ ID NO: 561:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 88 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...88

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 561:

Gly Asn Val Lys Val Asn Lys Lys His Arg Leu Ala Phe Leu Gly Leu

1 5 10 15

He Val Gly Val Leu Phe Phe Phe Ser Ala Cys Gin His Arg Leu His

20 25 30

Met Gly Tyr Tyr Ser Glu Val Thr Gly Asp Tyr Leu Phe Asn Tyr Asn

35 40 45

Ser Thr He Val Val Ala Tyr Asp Arg Ser Asp Ala Met Thr Ser Tyr

50 55 60

Tyr He Asn Val He Val Tyr Glu Leu Gin Lys Leu Gly Phe Tyr Asn 65 70 75 80

Val Phe Thr Gin Ala Asn Ser Arg 85

(2) INFORMATION FOR SEQ ID NO: 562: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 165 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...165

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 562:

Lys Ala Leu Met Val Gly Met Lys Thr Gly Ala Trp Thr Gly Leu Lys

1 5 10 15

Leu Phe Ala Gin Pro Leu Leu Val Val Leu Ala Phe Met Leu Leu Tyr

20 25 30

Ala Leu Ala His Ala Val Leu Gly Phe Tyr Val Lys Lys Asp Ser Ala

35 40 45

Pro Met Ser Pro Asn Val Glu Lys Ser Glu Thr Glu Arg Gin Asn Ser

50 55 60

Thr Phe Ser Pro Lys Glu Glu Ala Asn Ala Thr Thr Thr Ala Thr Glu 65 70 75 80

Gin Asn Pro Thr Lys Asp Thr Val Pro Pro Leu Asp Thr Ala Thr Gin

85 90 95

Lys Gin Glu He Lys Gin Glu He Lys Gin Glu He Lys Gin Glu He

100 105 110

Lys Gin Glu He Lys Gin Glu He Lys Gin Glu He Lys Gin Glu Thr

115 120 125

Lys Gin Glu Gin Glu Lys Glu Asn Lys Pro Lys Gin Asn Ser Val Ser

130 135 140

Pro Val Gin Asn Asp Gin Lys Thr Pro Thr Thr Pro Leu Met Gly Lys 145 150 155 160

Lys Thr Ser Arg Val 165

(2) INFORMATION FOR SEQ ID NO: 563:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 97 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE: (A) NAME/KEY: misc_feature

(B) LOCATION 1...97

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 563 :

Met Leu Tyr Ala Ser Lys Ala Arg Leu Phe Leu Gin H e Lys Gly Lys

1 5 10 15

Phe Met Leu Arg He Leu He Pro Leu Leu He He Val Trp Val Leu

20 25 30

Trp Arg Leu Phe Leu Arg Gin Lys Pro His Lys Asp Asp His Arg Asp

35 40 45

Asn His Ser Tyr Thr Gin Gin Thr Pro Lys Glu Leu Glu Asp His Met

50 55 60

He Val Cys Ser Lys Cys Gin Thr Tyr Val Ser Ser Lys Asp Ala He 65 70 75 80

Tyr Ser Gly Ala Val Ala Tyr Cys Ser Glu Thr Cys Leu Lys Asp Lys

85 90 95

Gly

(2) INFORMATION FOR SEQ ID NO: 564:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 84 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...84

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 564 :

Lys Thr He Asn Lys Leu Arg He He Met Lys Pro Thr Asn Glu Pro

1 5 10 15

Lys Lys Pro Phe Phe Gin Ser Pro He Val Leu Ala Val Leu Gly Gly

20 25 30

He Leu Leu He Phe Phe Leu Arg Ser Phe Asn Ser Asp Gly Ser Phe

35 40 45

Ser Asp Asn Phe Leu Ala Ser Ser Thr Lys Asn Val Ser Tyr His Glu

50 55 60

He Lys Gin Leu He Ser Asn Asn Glu Val Glu Asn Val Ser He Gly 65 70 75 80

Gin Thr Leu He

!2) INFORMATION FOR SEQ ID NO: 565:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 230 amino acids (B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...230

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 565:

Phe Lys Asn Asn Lys Thr Pro Leu Thr Phe Glu Arg Asp Lys Gly Ser

1 5 10 15

Leu Asp Gly Leu Lys Lys Glu Arg Gin Gly Phe Tyr Lys Gin Val His

20 25 30

Tyr Leu Arg He Leu He Leu Ser Met Ser Phe Leu Asn He Leu Asn

35 40 45

Ala Glu Asn Leu Ser Tyr Met Ser Ser Ser Tyr Gin He Gly Thr Val

50 55 60

Phe Met Arg Pro Leu Asn Thr Asn Lys Leu Leu Gin Gly Ala Ser He 65 70 75 80

Leu Gin Gly Tyr Glu Val Asn Pro Lys Asn Asp Trp Ala Tyr Ser Arg

85 90 95

Tyr Tyr Phe Phe He Asp Tyr Gly Asn Val Leu Phe Asn Asn Asp Ser

100 105 110

Thr Leu Gin Ala Asn Met Phe Thr Tyr Gly Val Gly Gly Asp Phe Met

115 120 125

Val Ala Tyr Ala Lys Asn Pro He Asn Arg Trp Ala Phe Phe Phe Gly

130 135 140

Leu Gin Leu Ala Ala Asn Thr Trp He Leu Asn Asn Lys Val Lys Asp 145 150 155 160

Leu Val Val Asn Thr Trp Asp Ser Leu Lys Asp Phe Asn Phe His Asn

165 170 175

Thr Tyr Phe Arg Ala He Gly Lys Phe Gly Val Gin Phe Arg Thr He

180 185 190

Val Leu Tyr His Lys Val Asp Val Glu He Gly Met Lys He Phe Leu

195 200 205

Thr Pro Glu Arg Arg Ser Leu Phe Glu Arg Ser Phe Leu Phe Phe Val

210 215 220

Ser His Ser Trp His Phe 225 230

(2) INFORMATION FOR SEQ ID NO: 566:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 209 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...209

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 566 :

Gly He Cys Leu Lys Phe Gin He Val Ser Leu Leu Leu Ala Phe Leu

1 5 10 15

Leu Ala Ser Cys Leu Pro Pro Lys Gly His His Ser Gly Leu Val Asn

20 25 30

Met Tyr He Ala His Gin Gly Gin Ser Val Arg Thr Tyr Trp Arg Lys

35 40 45

Val Asp Arg Gly Val Val Ala Lys His Asn Glu Thr Leu Lys Glu Asn

50 55 60

Pro Lys He Lys Leu Lys Asp Pro Lys Gly Pro Leu Phe Met Leu Gly 65 70 75 80

Ser Asn Arg Phe Met Leu Leu Trp Lys Asn Arg Tyr Thr Leu Ala Lys

85 90 95

Val Gin Ser Phe Lys Leu Glu Pro Gly Phe Tyr Tyr Leu Asp Ser Phe

100 105 110

Ser Val Glu Thr Gin Lys Gly He Leu Gin Ser Ala Pro Gly Tyr Ser

115 120 125

Tyr Thr Lys Asn Gly Tyr Asp Phe Lys Asn Asn Arg Pro Phe Phe Leu

130 135 140

Ala Phe Glu Val Lys Pro Asp Ser Lys He Val Leu Pro Ser Val Glu 145 150 155 160

Leu Ser Leu He Lys Thr Pro Arg Gly Phe Leu Gly Val Phe Leu Phe

165 170 175

Asp Asn Asn Glu Lys Gly Ala Asn Thr Pro Trp He Glu Gly Ser Leu

180 185 190

Asn Leu Lys Leu Lys Asn Ala Ser Phe Lys Asp Ala Trp Glu Leu Glu

195 200 205

Arg

(2) INFORMATION FOR SEQ ID NO: 567:

(d) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 170 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...170 (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 567:

Lys Pro Phe Gly Tyr Leu Gly Leu Leu Tyr Lys Gin Gly Thr Gin Lys

1 5 10 15

Asn Pro His Ser Tyr Val Gly Ala Pro Ala Arg Leu Gly Val Asp Phe

20 25 30

Ser Tyr Ser Asn Gly Trp Ser Phe Gly He Gly Ala He Gly Ala Trp

35 40 45

Asn He Tyr Asn Lys Gin Arg Leu Ala Asn Leu Tyr He Ser Leu Gly

50 55 60

Asn Phe Phe Gly Asn Pro Asn Asn Val Lys Pro Tyr Leu Ser Ala Gly 65 70 75 80

Asp Val Ser Asp Ala Tyr Leu Gin Tyr Ala Asn Gin Arg Phe Lys He

85 90 95

Ala Leu Gly Arg Phe Asn Thr Asp Phe Val Asp Phe Asp Trp He Gly

100 105 110

Gly Asn He Gin Gly Val Ser Val Ala Phe Lys Gin Asn Ser Met Arg

115 120 125

Tyr Phe Gly He Phe Met Asp Ser Met Leu Tyr Asn Gly His Gin He

130 135 140

Asn Lys Glu Gin Gly Asn Arg He Ala Thr Phe Leu Asn Ala Leu Ala 145 150 155 160

Leu Met He Leu Cys Leu Asn Ala Cys Met 165 170

(2) INFORMATION FOR SEQ ID NO: 568:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 195 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...195

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 568:

Leu Gly Ser Pro Met Gin Phe Gin Lys Thr Leu Ser Ser Leu Ser Leu

1 5 10 15

Phe Leu Ser Leu Ser Leu Phe Leu Ser Phe Ser He Ala Glu Glu Asn

20 25 30

Gly Ala Tyr Ala Ser Val Gly Phe Glu Tyr Ser He Ser His Ala Val

35 40 45

Glu His Asn Asn Pro Phe Leu Asn Gin Glu Arg He Gin Thr He Ser

50 55 60

Asn Ala Gin Asn Gin He Tyr Lys Leu Asn Gin He Glu Asn Glu He 65 70 75 80

Thr Asn Met Gin Asn Thr Phe Asn Tyr Thr Asn Asn Ala Leu Lys Asn 85 90 95 Asn Ala Lys Leu Thr Pro Thr Glu Met Gin Ala Glu Gin Tyr Tyr Leu

100 105 110

Gin Ser Thr Leu Gin Asn He Glu Lys He Val Met Leu Ser Gly Gly

115 120 125

Val Ala Ser Asn Pro Lys Leu Val Gin Ala Leu Glu Lys Met Gin Glu

130 135 140

Pro He Thr Asn Pro Leu Glu Leu Val Glu Asn Leu Lys Asn Leu Glu 145 150 155 160

Leu Gin Phe Ser Gin Ser Gin Asn Ser Met Leu Ser Ser Leu Ser Ser

165 170 175

Gin He Ala Gin He Ser Asn Ser Leu Asn Ala Leu Asp Pro Ser Ser

180 185 190

Tyr Ser Lys 195

(2) INFORMATION FOR SEQ ID NO: 569:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 72 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL : YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...72

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 569:

Lys Gly Lys Val Met Asn Ser Ser Asn Leu Lys Asn Trp Leu Phe Pro

1 5 10 15

Thr He Cys Phe Phe Leu Phe Cys Tyr He Leu He Phe Leu He Phe

20 25 30

Phe Met Phe Lys Asn Leu Gin Ser Gin Ser Phe Gly Ser Val Ala Glu

35 40 45

Thr Gly Lys Lys Pro He Thr Thr Thr Lys Lys Phe Gly Lys Glu Leu

50 55 60

Gin Lys Gin He Ser Lys He His 65 70

(2) INFORMATION FOR SEQ ID NO: 570:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 278 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...278

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 570:

Leu Met Arg Lys Val Leu Tyr Ala Leu Met Gly Phe Leu Leu Val Phe

1 5 10 15

Ser Ala Leu Lys Ala Asp Asp Phe Leu Glu Glu Ala Asn Glu Thr Ala

20 25 30

Pro Ala Asn Leu Asn His Pro Met Gin Asp Leu Asn Ala He Gin Gly

35 40 45

Ser Phe Phe Asp Lys Asn Arg Ser Lys Met Ser Asn Thr Leu Asn He

50 55 60

Asp Tyr Phe Gin Gly Gin Thr Tyr Lys He Arg Leu Arg Tyr Ala Met 65 70 75 80

Ala Thr Leu Leu Phe Phe Ser Lys Pro He Ser Asp Phe Val Leu Gly

85 90 95

Asp Lys Val Gly Phe Asp Ala Lys He Leu Glu Ser Asn Asp Arg He

100 105 110

Leu Leu He Lys Pro Leu Gin He Gly Val Asp Ser Asn He Ser Val

115 120 125

He Asp Ser Glu Gly Lys He Phe Ser Phe Tyr Val Phe Ser Thr Thr

130 135 140

Phe Thr Ser Ser Lys His Pro Asn Leu Gin Val Phe He Glu Asp Lys 145 150 155 160

Asn Tyr Tyr Thr Asn Ala Phe He Lys Pro Gin Lys Glu Asn Gin Glu

165 170 175

Asn Met Ser Glu Asn Ala Pro Lys Asp Ala Gin Lys Asn Asn Lys Pro

180 185 190

Leu Lys Glu Glu Lys Glu Glu Thr Lys Glu Lys Glu Glu Glu Thr He

195 200 205

He He Gly Asp Asn Thr Asn Ala Met Lys He He Lys Lys Asp He

210 215 220

Gin Lys Gly Tyr Lys Ala Leu Lys Ser Ser Gin Arg Lys Trp Tyr Cys 225 230 235 240

Leu Trp Ala Cys Ser Lys Lys Ser Lys Leu Ser Leu Met Pro Lys Glu

245 250 255

He Phe Asn Asp Lys Gin Phe Thr Tyr Phe Lys Phe Asp Lys Arg Leu

260 265 270

Ala Leu Ser Lys Ser Arg 275

(2) INFORMATION FOR SEQ ID NO: 571:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 60 amino acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE

(A) ORGANISM Helicobacter pylori

(ix) FEATURE

(A) NAME/KEY mιsc_feature

(B) LOCATION 1.. 60

( xi ) SEQUENCE DESCRI PTION SEQ ID NO . 571 .

Tyr Arg Glu Met Asp Tyr Ala Val Phe Ser Met Thr He Hi s Pro Asp

1 5 10 15

Val Ser Ala Arg Pro Gin Val Leu Leu Met His Glu Lys He He Glu

20 25 30

His He Asn Gin His Glu Gly Val Ala Trp Val Thr Phe Asn Glu He

35 40 45

Ala Asp Asp Phe Leu Lys Arg Asn Pro Arg Lys Lys 50 55 60

(2) INFORMATION FOR SEQ ID NO: 572:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 78 ammo acids

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...78

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 572 :

Leu Val Leu Gin Gly Ala Glu Val Leu He Tyr Pro Ser Ala Phe Gly

1 5 10 15

Lys Ala Arg Ala Tyr Asn Trp Asp Leu Leu Ser Lys Ala Arg Ala Leu

20 25 30

Glu Asn Gly Cys Phe Val Cys Ala Cys Asn His Ser Gly Glu Glu Thr

35 40 45

Asn Ala Lys Leu Lys Gin Thr Leu Glu Phe Ala Gly Asp Ser Arg Asn

50 55 60

His Arg Thr Gin Trp Glu Asn His Arg Pro Ser His Gin Ala 65 70 75

(2) INFORMATION FOR SEQ ID NO: 573:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 61 ammo acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...61

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 573 :

Asn Leu Pro Val He Gin Gly He He Ala Pro Asn Gly Lys He He

1 5 10 15

Ala Gin Ala Thr Lys Leu Asn Glu Val He He Ala Glu Met Asp Leu

20 25 30

Asn Glu Val Ala Leu Gin Arg Gin Lys He Pro Tyr Leu Gin Asp Phe

35 40 45

Asp Thr Lys Leu Thr Lys Lys Gly Phe Gly Lys Leu Thr 50 55 60

(2) INFORMATION FOR SEQ ID NO: 574:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 162 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...162

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 574 :

He lie Met Phe Gly Met Gly Phe Phe Glu He Leu Val Val Leu He

1 5 10 15

Val Ala He He Phe Leu Gly Pro Glu Lys Phe Pro Gin Ala Val Val

20 25 30

Asp He Val Lys Phe Phe Arg Ala Val Lys Lys Thr Leu Asn Asp Ala

35 40 45

Lys Asp Thr Leu Asp Lys Glu He Asn He Glu Glu He Lys Lys Glu

50 55 60

Thr Leu Glu Tyr Gin Lys Leu Phe Glu Asn Lys Val Glu Ser Leu Lys 65 70 75 80

Gly Val Lys He Glu Glu Leu Glu Asp Ala Lys Val Thr Ala Glu Asn

85 90 95

Glu He Lys Ser He Gin Asp Leu Met Gin Asp Tyr Lys Arg Ser Leu

100 105 110

Glu Thr Asn Thr He Pro Asn His Leu Asn Glu Glu Val Ser Asn Glu 115 120 125 Glu Ala Leu Asn Lys Glu Val Ser Ser Asp Glu Ser Pro Lys Glu Val

130 135 140

Gin Leu Thr Thr Asp Asn Asn Ala Lys Glu His Asp Lys Glu Lys Glu 145 150 155 160

His Val

(2) INFORMATION FOR SEQ ID NO: 575:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 185 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...185

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 575:

Arg Tyr Arg Ser Phe Ser Arg Asn Gin Ser Asn Phe Arg Arg Cys Glu

1 5 10 15

Gin Pro Tyr Gly Ser Thr Leu Asn Ser Val Pro Leu Trp He Met Val

20 25 30

Val Gly Ala Ala Gly He Ala Leu Gly Leu Ser Leu Tyr Gly Pro Lys

35 40 45

Leu He Lys Thr Val Gly Ser Glu He Thr Glu Leu Asp Lys Met Gin

50 55 60

Ala Phe Cys He Ala Leu Ser Ala Val He Thr Val Leu Leu Ala Ser 65 70 75 80

Gin Leu Gly Leu Pro Val Ser Ser Thr His He Val Val Gly Ala Val

85 90 95

Phe Gly Val Gly Phe Leu Arg Glu Arg Leu Arg Glu Gin Ser Arg Arg

100 105 110

Arg Phe Ala Arg He Arg Asp Asn He Val Ala Ala His Phe Gly Glu

115 120 125

Asp Leu Glu Glu He Glu Gly Phe Leu Glu Arg Phe Asp Lys Ala Asn

130 135 140

Leu Lys Glu Lys Ser Leu Met Leu Glu Ser Leu Lys Lys Ser Lys Asn 145 150 155 160

Thr Ala He Ala Leu Glu Leu Lys Lys Lys Asp Lys Lys Ser Leu Lys

165 170 175

Lys Val Tyr Lys Glu Glu Val He Lys 180 185

(2) INFORMATION FOR SEQ ID NO: 576:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 105 amino acids

(B) TYPE: amino acid (D) TOPOLOGY, linear

(11) MOLECULE TYPE: protein

(m) HYPOTHETICAL ^• YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...105

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 576 :

Ala Gin He Phe Val Arg Phe Asn Tyr Val Leu Gly Ala He Gly Phe

1 5 10 15

Val Val Leu Leu Tyr Glu He He Ser Phe He Tyr Tyr Lys Arg Ser

20 25 30

Leu Val Tyr Leu He Leu Gly Val Ala He Gly Ala Leu Cys Leu Leu

35 40 45

Phe Val Phe Tyr Tyr Thr Pro Tyr He Leu Asn Ala Gin Lys Val Gly

50 55 60

Glu Val Ala Leu Gin Ser Ala Glu Phe Ala Arg Ser His Ala Gin Ser 65 70 75 80

Glu Trp Leu Phe Lys Glu Leu Phe Val Leu Val Cys Ala Leu Phe Phe

85 90 95

Trp Arg Leu Phe Gly Lys Asn Ala Leu 100 105

(2) INFORMATION FOR SEQ ID NO: 577:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 116 ammo acids

(D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(in) HYPOTHETICAL: YES

(Vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...116

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 577:

Lys Ala Cys Lys Met Lys Cys Ser Ser Phe Thr Ser Asn Ser Val Leu

1 5 10 15

Asn Phe Phe Val Val Leu Ser Phe He Thr He Gly Leu Val Phe Phe

20 25 30

Phe Leu Arg Ser Gin Pro Thr Ser Val Val Ser Lys Glu Asn He Pro

35 40 45

Lys He Glu Leu Glu Asn Phe Lys Ala Phe Gin He Asn Asp Lys He 50 55 60

Leu Asp Leu Ser He Glu Gly Lys Lys Ala Leu Gin Tyr Asp Asp His 65 70 75 80

Glu He Phe Phe Asp Ser Lys He Lys Arg Tyr Asp Glu Asp Thr He

85 90 95

Glu Ser Val Glu Ser Pro Glu Ala Lys Arg Gin Gin Asp Leu Tyr Phe

100 105 110

Phe Pro Asn Gly 115

(2) INFORMATION FOR SEQ ID NO: 578:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 105 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...105

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 578 :

Asn Gin Thr Lys Pro Glu Arg Lys Glu Lys He Pro Hi s Phe Gin Arg

1 5 10 15

Arg Val Leu Met Arg Trp Trp Cys Phe Leu Val Cys Cys Leu Ser Val

20 25 30

Leu Ser Val Met Asp Ala Lys Lys Leu Glu Asn Lys Gly Leu Lys Lys

35 40 45

Glu Arg Glu Leu Leu Glu He Thr Gly Asn Gin Phe Val Ala Asn Asp

50 55 60

Lys Thr Lys Thr Ala Val He Gin Gly Asn Val Gin He Lys Lys Gly 65 70 75 80

Lys Asp Arg Leu Phe Ala Asp Lys Val Ser Val Phe Leu Asn Asp Lys

85 90 95

Arg Lys Pro Glu Arg Tyr Glu Ala Ala 100 105

(2) INFORMATION FOR SEQ ID NO: 579:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 319 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE: (A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...319

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 579:

Lys Glu Ser Asn Ser Met Asp Leu Asp Lys Leu Lys Asp Tyr Arg Ala

1 5 10 15

Leu Arg Asn Ala He Leu Arg Leu Leu Pro Tyr Leu Asp Ser Gly He

20 25 30

Thr Glu Leu He Met Asn Lys Glu Lys Glu He Trp Leu Tyr Lys Leu

35 40 45

Asn Gly Val Arg Glu Lys Val Phe Asp Glu Asn Leu Asp Lys Ala Phe

50 55 60

He Leu Gly Phe Gly Glu Gin Leu Ala Ser Phe Arg Asp Leu Phe Phe 65 70 75 80

Asn Ala Asn Tyr Pro Thr Leu Asn Thr Ser He Pro Thr Ser Arg Tyr

85 90 95

Arg Val Ser Met Asn His Phe Ala He Ser Ala Asp Asn Glu Leu Ser

100 105 110

Leu Asn He Arg Val Pro Ser Asp Lys Lys Phe Asp Leu Lys Ala Phe

115 120 125

Lys Leu Ser Ser He Cys Gin Tyr Asp Tyr Glu Tyr Leu Lys Asn Leu

130 135 140

Met He Asp Gly Lys Asn Leu Leu He Ser Gly Gly Thr Gly Ser Gly 145 150 155 160

Lys Thr Ser Phe Leu Asn Ala Leu He Glu Phe He Pro Lys His Thr

165 170 175

Arg He Val Ser Val Glu Asp Ser Glu Glu Leu Asp Leu Arg Ala Phe

180 185 190

Glu Asn His Lys Ser Leu Leu Val Asp Lys Thr Glu Ser Ser Lys Phe

195 200 205

Thr Tyr Glu Asn Ala Leu Asn Met Ala Met Arg Met Ser Pro Asp Arg

210 215 220

Leu Met Val Gly Glu He Asp Thr Arg Asn Ser Met Leu Phe Leu Arg 225 230 235 240

Phe Gly Asn Thr Gly His Lys Gly Met Val Ser Thr Leu His Ala Asp

245 250 255

Ser Val His Gly Val He Glu Ala He Ala Leu Asn Leu Gin Met Asn

260 265 270

Lys Ser Gly Leu Asp Val Asn Val Ala Lys Lys Phe Phe Lys Ser Ser

275 280 285

Val Asp Val Val Val Gin He Val Leu Asp Lys Ala Thr Asn Thr Arg

290 295 300

Tyr He Gin Glu He Leu Pro Ala Lys Asp Leu Arg Asp Ser Leu 305 310 315

(2) INFORMATION FOR SEQ ID NO: 580:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 87 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...87

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 580:

Gly Val Lys Ala Met Asn Tyr Asp Val Leu Met Gly Phe Leu Ala Leu

1 5 10 15

He Leu Leu He Leu Trp Tyr Ala Tyr Gly Leu Arg Gin Tyr Leu Lys

20 25 30

Leu Lys Asp Lys Asn Lys Arg Leu Lys Glu Lys Leu Gin Arg Cys Asn

35 40 45

Cys Asn He Lys He Pro Ser He Leu Glu Met Ala His Lys Pro He

50 55 60

He Met Asp He Lys Gly Glu Leu Leu Pro His Leu Thr Glu Ser Tyr 65 70 75 80

Arg Lys Ser Lys Phe Lys Glu 85

(2) INFORMATION FOR SEQ ID NO: 581:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 95 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...95

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 581:

Leu Ser Arg Asn Gly Val Val Ser Ser Val Ser Ser Asp Gly Ser Lys

1 5 10 15

He Leu Met Ser Leu Ala Pro Asp Gly Gin Pro Asp Val Tyr Leu Tyr

20 25 30

Asp Thr His Lys Lys Thr Lys Thr Lys He Thr Arg Tyr Pro Gly He

35 40 45

Asp Val Ser Gly Val Phe Leu Glu Asp Asp Lys Ser Met Ala Phe Val

50 55 60

Ser Asp Arg Ser Gly Tyr Pro Asn He Tyr Met Lys Lys Leu Gly Leu 65 70 75 80

Lys Glu Arg Arg Ser Asn Ser Phe Met Lys Glu Glu Ala Met Asn 85 90 95 (2) INFORMATION FOR SEQ ID NO: 582.

(l) SEQUENCE CHARACTERISTICS-

(A) LENGTH: 146 ammo acids

(D) TOPOLOGY, linear

(ii) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...146

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 582 :

Gly Asp Lys Met Leu Lys Lys Leu Leu Leu He Ser Leu Phe Leu Gly

1 5 10 15

Phe Leu Arg Ala Glu Gly Glu His Tyr Glu He He Ala Glu Leu Ser

20 25 30

Lys Ala Phe Leu Lys Ala Lys Glu Val Leu Thr Ala He Asn Lys Thr

35 40 45

Tyr Lys Thr Cys He Glu Thr Gly His Asp Arg Thr Gin He Arg Leu

50 55 60

Gin Asn Asp Phe Leu Glu Asn Leu Ser Gin Thr Glu Gin Gin Phe Asp 65 70 75 80

Asp Tyr Phe Glu Lys Asp Phe Lys Ser Val Gly Val Leu Lys Thr Leu

85 90 95

Leu Lys Asp He Gin Ser Leu Glu Lys Thr Ser Asn Lys Leu Val Cys

100 105 110

Val Ala Pro Lys Asn Ala Lys Asn Phe Glu He Leu Glu Gly Ala He

115 120 125

Thr Gin He He Gly Leu Glu Glu Gin Met Asn Gin Phe He Asn Gly

130 135 140

Ala Lys 145

(2) INFORMATION FOR SEQ ID NO: 583:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 115 ammo acids

(D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE: (A) NAME/KEY: misc_feature

(B) LOCATION 1...115

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 583 :

He Gin Arg Leu Lys Glu Met Leu Arg Asn Gin Phe Arg H e Val Phe

1 5 10 15

Val Thr Cys He Val Ala Ser Ser Leu Gin Ala Gin Glu Asn Thr Pro

20 25 30

Thr Leu Gly Lys Val Thr Thr Lys Gly Glu Arg Thr Phe Glu Tyr Asn

35 40 45

His Gin Met Tyr Thr Asp Arg Lys Glu Leu Gin Gin Arg Gin Ser Asn

50 55 60

Gin Thr Arg Asp He Phe Arg Thr Arg Ala Asp Val Asn Ala Ala Ser 65 70 75 80

Gly Gly Leu Met Ala Gin Lys He Tyr Ala Arg Gly He Glu Ser Arg

85 90 95

Leu Leu Arg Val Thr He Asp Gly Val Ala Gin Asn Gly Asn He Phe

100 105 110

His His Asp 115

(2) INFORMATION FOR SEQ ID NO: 584:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 264 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...264

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 584 :

Ala Val Ser Trp He Met Ala Cys Trp Hi s Lys Arg Leu Ala Val Gly

1 5 10 15

Cys Cys He Val Leu Leu Ser Cys Val Met Ser Ala Asn Asn Val Ser

20 25 30

He Val Arg Asp Asp Pro Pro Leu Asp Pro Thr Leu Pro Ala Trp He

35 40 45

Tyr Ser Val Ala Leu Leu Lys Val Tyr Phe Ser Asp Gly Thr Tyr Lys

50 55 60

Glu Gly Tyr Ala Thr Leu Leu Glu Asn Gly Arg Tyr He Ala Ser Ser 65 70 75 80

Glu Thr Leu Tyr Ser Asn Gly Leu Tyr Pro Lys Met He Leu Ala Lys

85 90 95

Met Gin Asp Ser Ser Ala Lys Glu Leu He Cys He Ala Ser Leu His

100 105 110

Leu Glu Ala Met Asp Arg Asp Gin Gly Leu Ser Leu Leu Lys Thr Ala 115 120 125

Asp Phe Arg Asp Asp Tyr Cys His Lys Arg Glu Glu Ser Tyr Tyr His

130 135 140

Ala Arg He Tyr Ala Lys Tyr Ala Gin Thr Phe His Ser Asn Pro Tyr 145 150 155 160

Thr Asn Gin Lys Thr Pro Thr Ser Asp Leu Tyr Tyr Pro Ala Leu Asn

165 170 175

Glu Gly Asn Ser Phe Ser He Gin Thr Thr Asp He Ser Val Ala Glu

180 185 190

Leu Leu Lys Ser Lys Lys Phe Leu Ser Leu Asp Ala Ser Phe Lys Lys

195 200 205

Gly Ser Val Leu Trp Gly Gly Arg Pro Tyr Phe Ser Glu Val Gly Glu

210 215 220

Phe Met Gly Met Thr Ser Ser Thr Leu Glu Asn Gin Glu Ser Leu Val 225 230 235 240

He He Pro Lys Glu Lys He Ala Arg Phe Leu Ser Ala Leu Lys Asn

245 250 255

Gin Asn He Phe Pro Asn He Pro 260

(2) INFORMATION FOR SEQ ID NO: 585:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 147 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...147

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 585 :

Leu Gly Gly Leu Asp Met Tyr Lys Leu Gly He Phe Leu Leu Ala Thr

1 5 10 15

Leu Leu Ser Ala Asn Thr Gin Lys Val Ser Asp He Ala Lys Asp He

20 25 30

Gin His Lys Glu Thr Leu Leu Lys Lys Thr His Glu Glu Lys Asn Gin

35 40 45

Leu Asn Ser Arg Leu Ser Ser Leu Gly Glu Ala He Arg Ser Lys Glu

50 55 60

Leu Gin Lys Val Glu He Glu Arg Gin Met Val Ala Leu Lys Lys Ser 65 70 75 80

Leu Glu Lys Asn Arg Asn Glu Ser Leu Val Gin Glu Lys Val Leu Thr

85 90 95

Asn Tyr Arg Lys Ser Leu Asp His Leu Gin Lys Gin Arg Ser Phe Leu

100 105 110 .

Gin Lys Arg Val Phe Asp Thr Leu Leu Glu Asp Phe Leu Phe Ser Gin

115 120 125

Ala Leu Lys Gly Gin Asn Leu Ala Ser Ser Asn Asp Val He Leu Leu 130 135 140

Ser Gly Val 145

(2) INFORMATION FOR SEQ ID NO -586.

(l) SEQUENCE CHARACTERISTICS-

(A) LENGTH: 523 ammo acids

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE, protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...523

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 586 :

Tyr He Pro Phe Asn Leu Phe Gin Gly Gin Thr Asn Met Lys Lys Leu

1 5 10 15

Leu Tyr Thr Met Leu Ala Leu Leu Leu He Gly Leu Leu Thr Ala Tyr

20 25 30

Leu He Leu Phe Thr Glu Trp Gly Asn Lys He He Ala Ser Tyr He

35 40 45

Glu Lys Lys He Asn Pro Asn Glu Arg Tyr Leu Ser Val Lys Thr Phe

50 55 60

Lys Leu Arg Phe Asn Ser Leu Asp Phe Lys Ala Gin Ala Asn Asp Asp 65 70 75 80

Ser Thr Leu He Leu Lys Gly Asp Phe Ser Leu Leu Thr Gin Ser Val

85 90 95

Asn Leu Asp Tyr His He Asp He Lys Asn Leu Arg Ser Phe Lys Asp

100 105 110

Leu He Pro Tyr Pro Leu Arg Gly Ala He Val Thr Ser Gly Asn He

115 120 125

Lys Gly His Arg Lys Ala Leu Val Val Gin Gly Val Ser Asn Val Ala

130 135 140

Gin Ser His Thr Ala Tyr Asn Ala Leu Leu Asp Asp Phe Lys Leu Ser 145 150 155 160

His Leu Ser Leu Asn Ala Lys Asp Ala Asn Leu Glu Asp Leu Leu Tyr

165 170 175

Leu He Asn Arg Pro Ala Tyr Ala Asn Ala Lys Val Ser Leu Gin Ala

180 185 190

Asp Phe Asn Ser Leu Lys Pro Leu Glu Gly His Leu He Leu Thr Ala

195 200 205

Asn Asn Ala Leu He Asn Asn Ala Leu He Asn Gin He Phe His Leu

210 215 220

Asn Leu Lys Asp Thr Leu Val Phe Asn Leu Ser His Ser Ser Asp Phe 225 230 235 240

Lys Gly Asn Lys Ala He Ser Asp Thr Thr Leu Thr Ser Pro Leu Val

245 250 255

Asn Phe Thr Ala Leu Lys Ser Glu Tyr Ser Phe Pro Ala Leu Lys Leu 260 265 270

Asn Ala Pro Tyr Thr Leu Glu He Pro His Leu Ala Lys Leu Gin Asn

275 280 285

He Thr Asn His Pro Leu Lys Gly Ser Leu Thr Leu Lys Gly Asp He

290 295 300

Glu Gin Ser Pro Lys Leu Leu Lys Val Ser Gly His Ser Asn Leu Leu 305 310 315 320

Asp Gly Ala Leu Asp Phe Thr Leu Leu Asn Lys Asp Leu Lys Ala Arg

325 330 335

Phe Ser Asn He Ser Thr Ser Lys Ala Leu Asp Leu Phe His Tyr Pro

340 345 350

Lys Phe Phe Gin Ser He Ala Asp Ala Asn Leu Asp Tyr Asp Leu He

355 360 365

Ser Lys Gin Gly Val Leu Lys Ala Asn Leu Lys Asn Ala Arg Phe Leu

370 375 380

Lys Asn Ala Phe Ser Asp Phe Leu Tyr Ser He Ser Arg Phe Asp He 385 390 395 400

Thr Lys Glu He Tyr His Asp Ala Asn Leu Val Ser Gin He Asn Gin

405 410 415

Gin Arg Leu Leu Ser Asp Leu Ser Leu Lys Ser Pro Lys Thr Gin Leu

420 425 430

Lys He His Asn Gly Leu Leu Asp Leu Asn Thr Lys Gin Met Asp He

435 440 445

Leu Met Asp Ala Glu He Leu Lys Phe He Phe Lys Met Lys Leu Gin

450 455 460

Gly Ser Met His Gin Pro Lys Phe Ser Leu He Leu Asn Glu Lys Ala 465 470 475 480

He Gin Gin Asn Leu Gin Gin Gly Leu Lys Glu He Leu Lys Asn Asp

485 490 495

Thr Leu Lys Lys Gly Leu Asp His Leu Leu Lys Asp Asp Lys Leu Lys

500 505 510

Glu Lys Leu Glu Lys Gly Leu Lys Gly Leu Phe 515 520

(2) INFORMATION FOR SEQ ID NO: 587:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 222 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...222

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 587 :

Ala Phe Leu Tyr He His Ser He Ala Leu Ala Arg Val He Leu Gin

1 5 10 15

Leu Lys Pro Leu Leu Thr He His Leu Asn Ala Lys Ser Gin Ser Ser 20 25 30

Leu Lys Asn Lys He Thr Leu Lys Asn Lys Leu Asn His Ala Arg He

35 40 45

He Leu Glu Phe He Pro Ser Leu He Tyr Phe Leu He Gin Lys Val

50 55 60

Ser Val Leu Lys His Leu Ala Pro Leu He His He Pro Phe Lys Ala 65 70 75 80

Leu Trp Leu Gly Thr Ala Leu Ser Met Phe Leu Ser Leu Asn Leu Asn

85 90 95

Ala Glu Glu Asn Pro Thr Lys Thr Glu Pro Lys Pro Ala Lys Gly Val

100 105 110

Lys Asn Lys Pro Lys Ser Pro Val Thr Asn Val Met Met Thr Asn Cys

115 120 125

Asp Asn Leu Lys Asp Phe Asn Ala Lys Gin Lys Glu Val Leu Lys Ala

130 135 140

Ala Tyr Gin Phe Gly Ser Thr Glu Asn Leu Gly Tyr Glu Met Ala Gly 145 150 155 160

He Ala Trp Lys Glu Ser Cys Ala Gly Thr Tyr Lys He Asn Phe Ser

165 170 175

Asn Pro Ser Ala Gly He Tyr His Ala Tyr He Pro Ser Val Leu Lys

180 185 190

Ser Tyr Gly His Asn Asn Ser Pro Phe Leu Arg Asn Val Met Gly Arg

195 200 205

He Ala Thr Leu Lys Thr Met Arg Leu Leu Leu Lys Trp Pro 210 215 220

(2) INFORMATION FOR SEQ ID NO: 588:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 299 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_£eature

(B) LOCATION 1...299

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 588 :

Leu Val He He Ser Leu Leu Thr Thr Leu Lys Leu Lys Ser He Lys

1 5 10 15

Glu He Ser He Lys Lys Phe He Leu Ser Ser Leu Val Phe Ala Cys

20 25 30

He Asn Thr Gly Val Glu Ala Leu Glu Asn Asp Gly Ser Lys Pro Asn

35 40 45

Asp Leu Ala Ser Pro Lys Glu Thr Pro Lys Glu Ala Gin Lys Asn Glu

50 55 60

Ala Gin Asn Glu Thr Ser Gin Ser Asn Gin Thr Pro Lys Glu Met Lys 65 70 75 80

Val Lys Ser He Ser Tyr Val Gly Leu Ser Tyr Met Ser Asp Met Leu 85 90 95

Ala Asn Glu He Ala Lys He Arg Val Gly Asp Met Val Asp Ser Lys

100 105 110

Lys He Asp Thr Ala Val Leu Ala Leu Phe Asn Gin Gly Tyr Phe Lys

115 120 125

Asp Val Tyr Ala Thr Phe Glu Asn Gly He Leu Glu Phe His Phe Asp

130 135 140

Glu Lys Ala Arg He Ala Gly Val Glu He Lys Gly Tyr Gly Thr Glu 145 150 155 160

Lys Glu Lys Asp Gly Leu Lys Ser Gin Met Gly He Lys Lys Gly Asp

165 170 175

Thr Phe Asp Glu Gin Lys Leu Glu His Ala Lys Thr Ala Leu Lys Thr

180 185 190

Ala Leu Glu Gly Gin Gly Tyr Tyr Gly Ser Val Val Glu Val Arg Thr

195 200 205

Glu Lys Val Ser Glu Gly Ala Leu Leu He Val Phe Asp Val Asn Arg

210 215 220

Gly Asp Ser He Tyr He Lys Gin Ser He Tyr Glu Gly Ser Asp Lys 225 230 235 240

Leu Lys Arg Arg Val He Glu Ser Leu Ser Ala Asn Lys Gin Arg Asp

245 250 255

Phe Met Gly Trp Met Trp Gly Leu Asn Asp Gly Lys Leu Arg Leu Asp

260 265 270

Gin Leu Glu Tyr Asp Ser Leu Arg He Gin Asp Val Tyr Met Arg Arg

275 280 285

Gly Tyr Leu Asp Ala His He Ser Ser Pro Phe 290 295

(2) INFORMATION FOR SEQ ID NO: 589:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 288 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...288

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 589 :

Glu Phe Gly Val Lys Arg He Leu Phe Phe Leu Ala Ala Thr Thr Phe

1 5 10 15

Leu Leu Arg Ala Glu Thr Ala Ser Ala Thr He Asn Thr Thr Val Asp

20 25 30

Pro Asn Val Met Phe Ser Glu Ser Ser Thr Gly Asn Val Lys Lys Asp

35 40 45

Arg Lys Arg Val Leu Lys Ser Met Val Asp Leu Glu Lys Glu Arg Val

50 55 60

Lys Asn Phe Asn Gin Tyr Ser Glu Thr Lys Met Ser Lys Gly Asp Leu 65 70 75 80

Ser Ala Phe Gly Ala Phe Phe Lys Gly Ser Leu Glu Asp Cys Val Glu

85 90 95

Gin Lys He Cys Tyr Tyr Glu His Arg Asn Gly Lys Val Ser Phe Val

100 105 110

Val Asn Asp Arg Glu Lys Phe Tyr Lys His Val Leu Lys Asp Leu Gly

115 120 125

Thr Glu Leu Ser Leu Pro Leu Phe Asn Trp Leu Tyr Lys Gly Ser Asp

130 135 140

Phe Gly Ala Leu His Glu Gin Phe Gly Asp Met Tyr Asp Gly Tyr He 145 150 155 160

Lys Tyr Leu He Ser Met Val Arg Val Ser Gin Lys Glu Lys Ala Arg

165 170 175

Lys Val Asp Ala He Val Leu Lys Lys Met Glu Glu Gin Ala Glu Lys

180 185 190

Asp Thr Lys Ala Ala Phe Gin Lys Arg Ser Ser Gly Glu Leu Glu Ser

195 200 205

His Thr Asp Ser Pro Glu Phe He Ser Ser Ser Lys Thr Gin Asn Ser

210 215 220

Ser Asn Pro Asp Leu Asp Pro Met Thr Asn Ala Asn Thr Leu Lys Glu 225 230 235 240

Thr Ala Ser Lys Glu Pro Glu Thr Ser Ser Lys Lys Glu Lys Lys Pro

245 250 255

Lys Lys Lys Arg Arg Leu Ser Lys Lys Glu Lys Gin Gin Gin Ala Leu

260 265 270

Gin Gin Glu Phe Glu Lys Gin He Ser Asp Ser Ser Lys Ser Glu Lys 275 280 285

(2) INFORMATION FOR SEQ ID NO: 590:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 407 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...407

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 590 :

Ser Arg Thr Leu Cys Ala Lys He Val Leu Gin Lys Glu Arg Lys Lys

1 5 10 15

Met Glu He Gin Gin Thr His Arg Lys He Asn Arg Pro Leu Val Ser

20 25 30

Leu Val Leu Ala Gly Ala Leu He Ser Ala He Pro Gin Glu Ser His

35 40 45

Ala Ala Phe Phe Thr Thr Val He He Pro Ala He Val Gly Gly He

50 55 60

Ala Thr Gly Thr Ala Val Gly Thr Val Ser Gly Leu Leu Ser Trp Gly 65 70 75 80

Leu Lys Gin Ala Glu Glu Ala Asn Lys Thr Pro Asp Lys Pro Asp Lys

85 90 95

Val Trp Arg He Gin Ala Gly Lys Gly Phe Asn Glu Phe Pro Asn Lys

100 105 110

Glu Tyr Asp Leu Tyr Lys Ser Leu Leu Ser Ser Lys He Asp Gly Gly

115 120 125

Trp Asp Trp Gly Asn Ala Ala Arg His Tyr Trp Val Lys Gly Gly Gin

130 135 140

Trp Asn Lys Leu Glu Val Asp Met Lys Asp Ala Val Gly Thr Tyr Lys 145 150 155 160

Leu Ser Gly Leu Arg Asn Phe Thr Gly Gly Asp Leu Asp Val Asn Met

165 170 175

Gin Lys Ala Thr Leu Arg Leu Gly Gin Phe Asn Gly Asn Ser Phe Thr

180 185 190

Ser Tyr Lys Asp Ser Ala Asp Arg Thr Thr Arg Val Asn Phe Asn Ala

195 200 205

Lys Asn He Ser He Asp Asn Phe Val Glu He Asn Asn Arg Val Gly

210 215 220

Ser Gly Ala Gly Arg Lys Ala Ser Ser Thr Val Leu Thr Leu Gin Ala 225 230 235 240

Ser Glu Gly He Thr Ser Ser Lys Asn Ala Glu He Ser Leu Tyr Asp

245 250 255

Gly Ala Thr Leu Asn Leu Ala Ser Asn Ser Val Lys Leu Asn Gly Asn

260 265 270

Val Trp Met Gly Arg Leu Gin Tyr Val Gly Ala Tyr Leu Ala Pro Ser

275 280 285

Tyr Ser Thr He Asn Thr Ser Lys Val Gin Gly Glu Val Asp Phe Asn

290 295 300

His Leu Thr Val Gly Asp Gin Asn Ala Ala Gin Ala Gly He He Ala 305 310 315 320

Ser Asn Lys Thr His He Gly Thr Leu Asp Leu Trp Gin Ser Ala Gly

325 330 335

Leu Asn He He Ala Pro Pro Glu Gly Gly Tyr Lys Asp Lys Pro Asn

340 345 350

Ser Thr Thr Ser Gin Ser Gly Thr Lys Asn Asp Lys Lys Glu He Ser

355 360 365

Gin Asn Asn Asn Ser Asn Thr Glu Val He Asn Pro Pro Asn Asn Thr

370 375 380

Gin Lys Thr Glu Thr Glu Pro Thr Lys Ser Leu Met Gly Leu Leu Leu 385 390 395 400

Lys Ala Lys Thr Arg Leu Ser 405

(2) INFORMATION FOR SEQ ID NO: 591:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 163 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori ( ix ) FEATURE :

(A) NAME/KEY: misc_feature

(B) LOCATION 1...163

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 591 :

Gin He Phe Cys Ser Thr Gin Ser Ser Lys Leu Pro Leu Lys Lys Ala

1 5 10 15

Pro Lys Ala Asp Lys Ser Pro Leu Leu He Leu Val Ser Glu Tyr Trp

20 25 30

Leu Lys Phe Phe Thr Arg Ser Phe Ser Lys Ser Thr Met Leu Phe Lys

35 40 45

Thr Leu Leu Arg Ser Phe Phe Thr Phe Pro Val Glu Leu Ser Glu Asn

50 55 60

He Thr Leu Gly Ser Thr Val Val Leu He Val Ala Glu Ala Val Ser 65 70 75 80

Ala Leu Asn Lys Lys Val Val Ala Ala Lys Lys Asn Lys He Arg Phe

85 90 95

Thr Pro Asn Ser Tyr He His Asn Arg Asn Lys Asn Arg Arg Tyr Ser

100 105 110

Ser Leu Ser Pro Leu Leu Lys Ser Ser Ser He Cys Lys Asn Pro Pro

115 120 125

Arg He Gin Ala He Leu He He Leu Lys Tyr Arg Leu Ser Lys Gly

130 135 140

Phe Asn Pro Val Val Val He Leu Arg He Gin Lys Met Arg Thr Leu 145 150 155 160

Gin Lys Leu

(2) INFORMATION FOR SEQ ID NO: 592:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 201 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...201

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 592 :

Gly Leu He Thr Met Asp Lys Asn Asn Asn Asn Asn Leu Arg Leu He

1 5 10 15

Leu Ala He Ala Leu Ser Phe Leu Leu He Ala Leu Asn Ser Tyr Phe

20 25 30

Phe Gin Glu Pro Asn Lys Thr Thr Thr Glu Thr Thr Lys Gin Glu Thr

35 40 45

Thr Asn Asn His Thr Ala Thr Ser Pro Thr Ala Ser Asn Thr He Thr 50 55 60

Gin Asp Phe Ser Val Thr Gin Thr He Pro Gin Glu Ser Leu Leu Ser 65 70 75 80

Thr He Ser Phe Glu His Ala Lys He Glu He Asp Ser Leu Gly Arg

85 90 95

He Lys Gin Val Tyr Leu Lys Asp Lys Lys Tyr Leu Thr Pro Lys Glu

100 105 110

Lys Gly Phe Leu Glu His Val Ser His Leu Phe Ser Ser Lys Glu Asn

115 120 125

Ser Gin Pro Ser Leu Lys Glu Leu Pro Leu Leu Ala Ala Asp Lys Leu

130 135 140

Lys Pro Leu Glu Val Arg Phe Leu Asp Pro Thr Leu Asn Asn Lys Ala 145 150 155 160

Phe Asn Thr Pro Tyr Ser Ala Ser Lys Thr Thr Leu Gly Pro Asn Glu

165 170 175

Gin Leu Val Leu Thr Gin Asp Leu Gly Thr Leu Ser He He Lys Thr

180 185 190

Leu Thr Phe Tyr Asp Asp Leu His Tyr 195 200

(2) INFORMATION FOR SEQ ID NO: 593:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 68 ammo acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...68

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 593 :

Gly Val Ser He He Met Val Leu Lys Thr Lys Leu Lys He He Ser

1 5 10 15

Ser Val He Leu Ser Thr Leu Leu Trp Val Gly Cys Ser Ser Glu Met

20 25 30

Ala Thr Tyr Gin Asn Val Asn Asp Ala Thr Lys Asn Thr Thr Ala Ser

35 40 45

He Asn Ser Thr Asp Leu Leu Leu Thr Ala Asn Ala Met Leu Asp Ser

50 55 60

Met Leu Gly Thr 65

(2) INFORMATION FOR SEQ ID NO: 594:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 176 ammo acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear (11) MOLECULE TYPE, protein

(m) HYPOTHETICAL. YES

(vi) ORIGINAL SOURCE-

(A) ORGANISM Helicobacter pylori

(ix) FEATURE-

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...176

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 594 :

Ala Met Lys Asn Gin Val Lys Lys He Leu Gly Met Ser Val Val Ala

1 5 10 15

Ala Met Val He Val Gly Cys Ser His Ala Pro Lys Ser Gly He Ser

20 25 30

Lys Ser Asn Lys Ala Tyr Lys Glu Ala Thr Lys Gly Ala Pro Asp Trp

35 40 45

Val Val Gly Asp Leu Glu Lys Val Ala Lys Tyr Glu Lys Tyr Ser Gly

50 55 60

Val Phe Leu Gly Arg Ala Glu Asp Leu He Thr Asn Asn Asp Val Asp 65 70 75 80

Tyr Ser Thr Asn Gin Ala Thr Ala Lys Ala Arg Ala Asn Leu Ala Ala

85 90 95

Asn Leu Lys Ser Thr Leu Gin Lys Asp Leu Glu Asn Glu Lys Thr Arg

100 105 110

Thr Val Asp Ala Ser Gly Lys Arg Ser He Ser Gly Thr Asp Thr Glu

115 120 125

Lys He Ser Gin Leu Val Asp Lys Glu Leu He Thr Ser Lys Met Leu

130 135 140

Ala Arg Tyr Val Gly Lys Asp Arg Val Phe Val Leu Val Gly Leu Asp 145 150 155 160

Lys Gin He Val Asp Lys Val Arg Glu Glu Leu Gly Met Val Lys Lys 165 170 175

(2) INFORMATION FOR SEQ ID NO: 595:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 100 ammo acids

(D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...100

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 595: Pro Lys Pro Tyr Ala Val Ser He Leu Cys He Cys Val Met Phe He

1 5 10 15

Leu Phe Lys Phe Gly Arg Val Leu Gly Lys Ala Tyr Ser Leu Tyr Leu

20 25 30

Tyr He Tyr Glu Ser Leu He Cys Gin Ala Phe Gly Leu Ser Leu Ser

35 40 45

Cys Asn Asn Ser Met Leu Phe Ser Thr Phe Leu He Asn Leu Pro Leu

50 55 60

Pro His Asn Glu Ser Leu Cys Cys Cys Arg Asp He Leu Ala Tyr Ser 65 70 75 80

Asn Ser Ser Ser Leu Lys Thr Tyr Ser Leu Glu Ser Asn Phe Ser Phe

85 90 95

Asn Ser Leu Phe 100

(2) INFORMATION FOR SEQ ID NO: 596:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 100 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...100

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 596 :

Thr Ala Arg Met Asn Arg Met Lys Pro He Phe Leu Leu He Phe Leu

1 5 10 15

Leu Leu Ala Ser Leu He Ala Arg Glu Lys Asp Ala Ser Ser Asn Leu

20 25 30

Phe Asp Leu He Asp Lys Gly He Asn Arg Glu Gin Glu Leu Lys Glu

35 40 45

Gin Glu Gin Lys Thr Arg Leu Lys Leu Ala Gin Ser Pro Leu Val Ala

50 55 60

Leu Glu He Val Pro Gin Glu Thr Pro Tyr Leu Glu Trp Gin Gly Ala 65 70 75 80

Arg Glu Ser Tyr Tyr Leu Lys Val Glu Arg Cys Ser Gly Glu Arg Gly

85 90 95

Tyr Phe Lys Asp 100

(2) INFORMATION FOR SEQ ID NO: 597:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 231 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear (11) MOLECULE TYPE: protein

(m) HYPOTHETICAL : YES

(vi) ORIGINAL SOURCE.

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE-

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...231

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 597 :

Val Ala Arg Ala Phe He Ala Leu Tyr Ala He Ser Ala Val Asn Lys

1 5 10 15

Ser Lys Val Glu Ala Leu Lys Thr Glu Phe He Lys He Phe Asn Tyr

20 25 30

Ala Pro Lys Pro Glu Ala Met Gin Pro Val Val Val He Pro Pro Asp

35 40 45

Ser Gly Lys Glu Glu Glu Gin Met Ala Ser Glu Ser Ser Lys Pro Ala

50 55 60

Ser Gin Asn Thr Glu Thr Lys Ala Thr He Ala Arg Lys Gly Glu Gly 65 70 75 80

Ser Val Leu Glu Gin He Asp Gin Gly Ser Val Leu Lys Leu Pro Ser

85 90 95

Ser Leu Leu Phe Glu Asn Ala Thr Ser Asp Ala He Asn Gin Asp Met

100 105 110

Met Leu Tyr He Glu Arg He Ala Lys He He Gin Lys Leu Pro Lys

115 120 125

Arg Val His He Asn Val Arg Gly Phe Thr Asp Asn Thr Pro Leu Asn

130 135 140

Lys Thr Arg Phe Lys Ser His Tyr Glu Leu Ala Ala Asn Arg Ala Tyr 145 150 155 160

Arg Val Met Lys Val Leu He Gin Tyr Gly Val Asp Pro Asn Gin Leu

165 170 175

Ser Phe Ser Ser Tyr Gly Ser Thr Asn Pro He Ala Pro Asn Asp Ser

180 185 190

Leu Glu Asn Arg Met Lys Asn Asn Arg Val Glu He Phe Phe Ser Thr

195 200 205

Asp Ala Asn Asp Leu Ser Lys He His Ser He Leu Asp Glu Glu Phe

210 215 220

Asn Pro His Lys Gin Gin Glu 225 230

(2) INFORMATION FOR SEQ ID NO: 598:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 98 ammo acids

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(m) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori ( ix ) FEATURE -

(A) NAME/KEY mιsc_feature

(B) LOCATION 1. 98

( xi ) SEQUENCE DESCRI PTION SEQ ID NO : 598 :

Gin Arg Leu Tyr Leu Gly Lys Leu Asn Ala Lys Val Asn Hi s Thr He

1 5 10 15

Phe Gin Phe Leu Val Asn Val Gly He Arg Thr Asn He Phe Glu His

20 25 30

His Gly He Glu Phe Gly He Lys He Pro Thr Leu Pro Asn Tyr Phe

35 40 45

Phe Lys Gly Ser Thr Thr He Arg Ala Lys Lys Gin Gly Pro Leu Glu

50 55 60

Asn Gly Asn Pro Thr Thr He Thr Gly Ala Glu Thr Asn Phe Ser Leu 65 70 75 80

Thr Gin Thr Leu Arg Arg Gin Tyr Ser Met Tyr Leu Arg Tyr Val Tyr

85 90 95

Thr Phe

(2) INFORMATION FOR SEQ ID NO: 599:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 357 ammo acids

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi ) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...357

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 599.

Phe His Phe Tyr Cys Leu Tyr Phe Leu Asn Gly Gly Tyr Asn Arg Leu

1 5 10 15

His Lys Ser Tyr Glu Arg He Val Met Leu He Ala Arg Phe Lys Lys

20 25 30

Ala Leu He Ser Tyr Ser Leu Gly Val Leu Leu Val Ser Ser Leu Leu

35 40 45

Gly Val Ala Asn Ala Ser Asn Gin Glu He Gin Val Lys Asp Tyr Phe

50 55 60

Gly Glu Gin Thr He Lys Leu Pro Val Ser Lys He He Tyr Leu Gly 65 70 75 80

Ser Phe Ala Glu Val Pro Ala Met Phe Asn Thr Trp Asp Arg Val Val

85 90 95

Gly He Ser Asp Tyr Ala Phe Lys Ser Asp He Val Lys Ala Thr Leu

100 105 110

Lys Asp Leu Glu Arg He Lys Pro Met Ser Ser Asp His Val Ala Ala 115 120 125

Leu Asn Val Glu Leu Leu Lys Lys Leu Ser Pro Asn Leu Val Val Thr

130 135 140

Phe Val Gly Asn Pro Lys Ala Val Glu His Ala Lys Lys Phe Gly He 145 150 155 160

Ser Phe Leu Ser Phe Gin Glu Lys Thr He Val Glu Val Met Glu Asp

165 170 175

He Asp Ala Gin Ala Lys Ala Leu Glu Val Asp Ala Ser Lys Lys Leu

180 185 190

Ala Lys Met Gin Glu Thr Leu Asp Phe He Lys Glu Arg Leu Lys Asn

195 200 205

Val Lys Lys Lys Lys Gly Val Glu Leu Phe His Lys Ala Asn Lys He

210 215 220

Ser Gly His Gin Ala Leu Asp Ser Asp He Leu Glu Lys Gly Gly He 225 230 235 240

Asp Asn Phe Gly Leu Lys Tyr Val Lys Phe Gly Arg Ala Asp He Ser

245 250 255

Val Glu Lys He Val Lys Glu Asn Pro Glu He He Phe He Trp Trp

260 265 270

Val Ser Pro Leu Thr Pro Glu Asp Val Leu Asn Asn Pro Lys Phe Ser

275 280 285

Thr He Lys Ala He Lys Asn Lys Gin Val Tyr Lys Leu Pro Thr Met

290 295 300

Asp He Gly Gly Pro Arg Ala Pro Leu He Ser Leu Phe He Ala Leu 305 310 315 320

Lys Ala His Pro Glu Ala Phe Lys Gly Val Asp He Asn Ala He He

325 330 335

Lys Asp Tyr Tyr Lys Val Val Phe Asp Leu Asn Asp Ala Glu Val Glu

340 345 350

Pro Phe Leu Trp His 355

(2) INFORMATION FOR SEQ ID NO: 600:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 61 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

( B ) LOCATION 1...61

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 600 :

Asp His His Lys Glu Phe Arg Met Lys Lys Gin He Leu Thr Gly Val

1 5 10 15

Leu Leu Ser Val Leu Ala Val Ser Ser Ala Tyr Ala His Lys Asp Lys

20 25 30

Lys Asp Ala Lys Lys Pro Glu Leu Ser Ser Gin Leu Val Ala His Lys 35 40 45 sp Lys Lys Asp Ala Lys Lys Pro Lys Asn Ser Val Ala 50 55 60

(2) INFORMATION FOR SEQ ID NO: 601:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 200 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...200

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 601 :

Arg He He Lys Gly Asn He Met Ser Ser Gly Leu He Tyr He Ser

1 5 10 15

Leu Glu Val Leu Val Ala Cys Leu He Thr Ala Leu He Met Tyr Tyr

20 25 30

Val Met Lys Lys He Tyr Tyr Ala Arg Gly Gin Ala He Leu Lys Gly

35 40 45

Ala Ser Ala Lys Ala Lys Leu Met Glu Phe Gin Ala Lys Ser Phe Val

50 55 60

Glu Ala Glu Glu Met Arg Met Lys Ser Gin Glu Cys Lys Leu Gin Gin 65 70 75 80

Gin Tyr Glu Asn Lys Asn Leu Gin Leu Gin Thr His Phe Asp Lys Lys

85 90 95

Glu Ala His Leu Lys His Leu Glu Ala Gin His Lys Glu Phe Val Arg

100 105 110

Asp Glu Lys Arg Tyr Leu Glu Lys Glu Lys Lys Glu Leu Glu Lys Glu

115 120 125

Arg Gin He Leu Glu Gin Glu Arg Glu Asn Phe Lys Lys Gin Arg Ala

130 135 140

He Cys Lys Glu Ala Gin Ala Lys Ala Leu Asp Ala Met Leu Asn Tyr 145 150 155 160

Met Ala Tyr Thr Lys Asp Glu He Lys Ser Met He Leu Glu Gin Leu

165 170 175

Glu Gin Glu Leu Glu Ala Gin Lys Ser Ala Leu He Arg Arg Tyr Glu

180 185 190

Glu Glu Ala Phe He Met Cys Leu 195 200

(2) INFORMATION FOR SEQ ID NO: 602:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 167 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...167

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 602 :

Gly Arg Ala Phe Met Met Arg Glu He Leu Thr Asn Arg Phe Phe Pro

1 5 10 15

Ser Leu Phe Lys Lys Arg Leu Asp Phe Ser Asn Arg Val Val Leu Gly

20 25 30

Leu Gly Ser Asn Leu Lys Asn Pro Leu Lys He Leu Lys Ser Cys Phe

35 40 45

Leu Tyr Phe Lys Asn His Ser Lys He Gly Lys He Phe Ser Ser Pro

50 55 60

He Tyr He Asn Pro Pro Phe Gly Tyr Thr Asn Gin Pro Asn Phe Tyr 65 70 75 80

Asn Ala Thr He He Leu Lys Thr Ser Leu Gly Leu Arg His Phe Phe

85 90 95

Ala Leu Val Phe Tyr He Glu Arg Arg Phe Gly Arg Ala Arg Lys Arg

100 105 110

Asp Phe Lys Asp Ala Pro Arg Thr Leu Asp He Asp He He Ala Phe

115 120 125

Asn Gin Val He Leu Arg Gin Asn Asp Leu Thr Leu Pro His Pro Lys

130 135 140

Trp Ser Glu Arg Asp Ser Val Leu Val Pro Leu Thr Leu Gin Gin He 145 150 155 160

Leu Phe Lys Arg Glu Glu Trp 165

(2) INFORMATION FOR SEQ ID NO: 603:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 171 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...171

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 603: He He Glu He Leu Val He Gin Gly Pro Asn Leu Asn Met Leu Gly

1 5 10 15

His Arg Asp Pro Arg Leu Tyr Gly Met Val Thr Leu Asp Gin He His

20 25 30

Glu He Met Gin Thr Phe Val Lys Gin Gly Asn Leu Asp Val Glu Leu

35 40 45

Glu Phe Phe Gin Thr Asn Phe Glu Gly Glu He He Asp Lys He Gin

50 55 60

Glu Ser Val Gly Ser Asp Tyr Glu Gly He He He Asn Pro Gly Ala 65 70 75 80

Phe Ser His Thr Ser He Ala He Ala Asp Ala He Met Leu Ala Gly

85 90 95

Lys Pro Val He Glu Val His Leu Thr Asn He Gin Ala Arg Glu Glu

100 105 110

Phe Arg Lys Asn Ser Tyr Thr Gly Ala Ala Cys Gly Gly Val He Met

115 120 125

Gly Phe Gly Pro Leu Gly Tyr Asn Met Ala Leu Met Ala Met Val Asn

130 135 140

He Leu Ala Glu Met Lys Ala Phe Gin Glu Ala Gin Lys Asn Asn Pro 145 150 155 160

Asn Asn Pro Asn Asn Pro He Asn Asn Gin Lys 165 170

(2) INFORMATION FOR SEQ ID NO: 604:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 66 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...66

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 604 :

Pro Arg He He Ala Phe Phe Trp He Trp Gly Ser Asn Thr Asn Ala

1 5 10 15

He Ala Leu He Gly Leu Ala Arg Leu Phe Leu Asn Pro Lys Asp Phe

20 25 30

Val Phe Lys Arg Glu Gin Ser Phe Lys Asp Lys Glu Arg Gin Lys He

35 40 45

Tyr Asp He Val Lys Glu Ala Gin Glu Lys Ala He Gin Ala Leu Glu

50 55 60

Arg Gly 65

(2) INFORMATION FOR SEQ ID NO: 605:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 70 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...70

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 605 :

Arg Leu Trp Leu Trp Ala Val Phe Thr His Ser Thr Gly His Gly He

1 5 10 15

Asp Leu Asp He His Glu Leu Pro Tyr He Ser Ser Arg Ser Glu Thr

20 25 30

He Leu Glu Glu Gly Met Val Phe Ser Val Glu Pro Gly He Tyr He

35 40 45

Pro Gly Phe Phe Gly Val Arg He Glu Asp Leu Val Val He Lys Asn

50 55 60

Ser Arg Ala Glu Leu Leu 65 70

(2) INFORMATION FOR SEQ ID NO: 606:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 99 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...99

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 606 :

Tyr Gin Tyr He Gin Gin Gly Gly Gly Phe Gly Val Asn Val Gly Arg

1 5 10 15

Thr Leu Gly Asn Arg Thr His Val Ser Leu Gly Tyr Asn Leu Asn Val

20 25 30

Thr Lys Leu Leu Gly Phe Ser Ser Pro Leu Tyr Asn Arg Tyr Tyr Ser

35 40 45

Ser Val Asn Glu Val Ala Ser Pro Arg Gin Cys Ser Thr Pro Ala Ser

50 55 60

Val He He Asn Arg Leu Ser Gly Gly Arg Thr Pro Leu Val Pro Glu 65 70 75 80

Ser Cys Ser Ser Pro Gly Ala He Thr He Phe Thr Arg Asn Lys Arg

85 90 95

Tyr Leu Gly

(2) INFORMATION FOR SEQ ID NO: 607:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 92 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...92

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 607 :

Met Ala Cys Glu Phe Leu Lys Lys Pro Lys Tyr Tyr Lys Phe He Glu

1 5 10 15

Gly Ala Asn Tyr Leu Ser Leu Gly Leu Ser Met Val Val Ala He Leu

20 25 30

Met Gly Val Ala He Gly Tyr Gly Leu Lys Lys Leu Thr His He Ser

35 40 45

Trp Leu Phe Trp Leu Gly Val He Trp Gly Val Leu Ala Ser Phe Leu

50 55 60

Asn Val Tyr Lys Ala Tyr Lys Asn Met Gin Lys Asp Tyr Glu Glu Leu 65 70 75 80

Ala Lys Asp Pro Lys Tyr Thr Gin Asn Lys Thr Lys 85 90

(2) INFORMATION FOR SEQ ID NO: 608:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 89 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...89 (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 608:

Arg Asn Leu Met Lys Thr Thr Glu Asn Thr Asp Glu Thr His Leu Arg

1 5 10 15

Glu Thr Lys Asn Lys Leu Gly Arg Lys Pro Lys Ala Asp Ala Asn Lys

20 25 30

Lys Thr Arg Ala Val Ser Leu Tyr Phe Ser Asp Glu Gin Tyr Gin Lys

35 40 45

Leu Glu Lys Met Ala Asn Glu Glu Glu Glu Ser Val Gly Ser Tyr He

50 55 60

Lys Arg Tyr He Leu Lys Ala Leu Arg Lys He Glu Gin Gly Gly Gly 65 70 75 80

Phe He Ala Phe Asn Leu Phe Leu He 85

(2) INFORMATION FOR SEQ ID NO: 609:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 103 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...103

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 609 :

He Leu Lys Gly Gly Phe Leu Gly Phe Phe He Val Ala Leu Ser Ser

1 5 10 15

Tyr Tyr Gly Val Lys Lys Arg Leu Asp Leu Arg Lys Gin Asp Ser Lys

20 25 30

Glu Lys Glu Glu Lys Gin Lys Phe Gin Lys Phe Ala Leu Gly Leu Glu

35 40 45

Met Ser Phe Asn Val Trp Arg Leu Gly Gly Tyr Gly Val Leu Leu Gly

50 55 60

He Leu Gly Val Leu Leu Phe Leu His Leu Phe Asn Gly Leu Pro Phe 65 70 75 80

Leu He Gly Val Phe Val Ser Ser Leu Ser Ser Ala Leu Leu Arg Phe

85 90 95

Leu Asn Asn Asn Gly Lys Phe 100

(2) INFORMATION FOR SEQ ID NO: 610:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 257 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear (11) MOLECULE TYPE: protein

(m) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...257

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 610:

Ala Leu Thr Pro Asn Pro Met Lys Leu Pro Val Val Glu Ser Phe Phe

1 5 10 15

Ser Leu Gin Gly Glu Gly Lys Arg He Gly Lys Pro Ser Leu Phe Leu

20 25 30

Arg Leu Gly Gly Cys Asn Leu Ser Cys Lys Gly Phe Asn Cys Lys Thr

35 40 45

Leu Phe Asn Asp Glu He Leu Tnr Gly Cys Asp Ser Leu Tyr Ala Val

50 55 60

His Pro Lys Phe Lys Thr Ser Trp Asp Tyr Tyr Asn Glu Pro Lys Pro 65 70 75 80

Leu He Glu Arg Leu Val Asn Leu Ala Pro Asn Tyr Lys Asp Phe Asp

85 90 95

Phe He Leu Thr Gly Gly Glu Pro Ser Leu Tyr Phe Asn Asn Pro He

100 105 110

Leu Leu Ser Val Leu Glu His Phe Tyr His Lys Lys He Pro Leu Phe

115 120 125

Val Glu Ser Asn Gly Ser He Phe Phe Glu Phe Ser Pro He Leu Lys

130 135 140

Glu Leu His Phe Thr Leu Ser Val Lys Leu Ser Phe Ser Leu Glu Gin 145 150 155 160

Glu Ser Lys Arg He Asn Leu Lys Ala Leu Gin Asn He Leu Asn Asn

165 170 175

Ala Lys Ser Val His Phe Lys Phe Val Leu Glu Ser Gin Asn Ala Ala

180 185 190

His Ser He Ala Glu He Gin Ser Leu Leu Lys Gin Leu Ser Leu Lys

195 200 205

Asn Asn Glu He Phe Leu Met Pro Leu Gly Thr Thr Asn Asn Glu Leu

210 215 220

Asp Lys Asn Leu Lys Thr Leu Ala Pro Leu Ala He Glu His Gly Phe 225 230 235 240

Arg Leu Ser Asp Arg Leu His He Arg Leu Trp Asp Asn Lys Lys Gly

245 250 255

Phe

(2) INFORMATION FOR SEQ ID NO: 611:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 386 ammo acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein (ii..) HYPOTHETICAL- YES

(vi) ORIGINAL SOURCE.

(A) ORGANISM. Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY- mιsc_feature

(B) LOCATION 1...386

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 611:

Phe Lys Asp Gin Gly Met Asn Leu Asn Phe Met Pro Leu Leu His Ala

1 5 10 15

Tyr Asn His Val Ser He Asp Phe His Phe Asn Ser Ser Ala Arg Asp

20 25 30

Phe Cys Val His Glu Val Pro Leu Tyr Glu Phe Ser Asn Thr Gly Glu

35 40 45

His Ala Val He Gin Val Arg Lys Ser Gly Leu Ser Thr Leu Glu Met

50 55 60

Leu Gin He Phe Ser Gin He Leu Gly Val Lys He Ala Glu Leu Gly 65 70 75 80

Tyr Ala Gly Leu Lys Asp Lys Asn Ala Leu Thr Thr Gin Phe He Ser

85 90 95

Leu Pro Lys Lys Tyr Ala Pro Leu Leu Glu Lys Asn Thr Ser Asn Phe

100 105 110

Gin Glu Arg Asn Leu Lys He Leu Ser Leu Asn Tyr His His Asn Lys

115 120 125

He Lys Leu Gly His Leu Lys Gly Asn Arg Phe Phe Met Arg Phe Lys

130 135 140

Lys Met Thr Pro Leu Asn Ala Gin Lys Thr Glu Gin Val Leu Glu Gin 145 150 155 160

He Ala Gin Phe Gly Met Pro Asn Tyr Phe Gly Ser Gin Arg Phe Gly

165 170 175

Lys Phe Asn Asp Asn His Lys Glu Gly Leu Lys He Leu Gin Asn Glu

180 185 190

Thr Lys Phe Ala His Gin Lys Leu Asn Ala Phe Leu He Ser Ser Tyr

195 200 205

Gin Ser Tyr Leu Phe Asn Ser Leu Leu Ser Lys Arg Leu Glu He Ser

210 215 220

Lys He He Ser Ala Phe Ser Val Lys Glu Ser Leu Glu Phe Phe Lys 225 230 235 240

Gin Lys Asn Leu Ser Val His Ser Asn Ala Leu Lys Ala Leu Lys Asn

245 250 255

Gin Ala His Pro Phe Lys He Leu Glu Gly Asp Val Met Arg His Tyr

260 265 270

Pro Tyr Gly Lys Phe Phe Asp Ala Leu Glu Leu Glu Lys Glu Ser Glu

275 280 285

Arg Phe Leu Asn Lys Glu Ala Val Pro Thr Gly Leu Leu Asp Gly Lys

290 295 300

Lys Ala Leu Tyr Ala Lys Asn Leu Ser Leu Glu He Glu Lys Gly Phe 305 310 315 320

Gin His Asn Leu Leu Ser Gly His Ala Lys Thr Leu Gly Ser Arg Arg

325 330 335

Phe Phe Trp Val Phe Val Glu Asn He Thr Ser Gin Tyr He Lys Glu

340 345 350

Lys Ala Gin Phe Glu Leu Glu Phe Tyr Leu Pro Lys Gly Ser Tyr Ala 355 360 365 Ser Ala Leu Leu Lys Glu He Lys His Glu Lys Gly Glu Asn Asn Asp

370 375 380

Glu Phe 385

(2) INFORMATION FOR SEQ ID NO.612:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 63 ammo acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE-

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...63

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 612 :

Lys He Lys Gly Lys Glu Met Lys Phe Leu Asn Gly Leu Ala Gly Asn

1 5 10 15

Leu Leu He Val Val He Leu Leu Cys Val Val Val Phe Phe Ala Leu

20 25 30

Lys Ala He His He Gin Lys Glu Gin Ala Thr Asn Tyr Tyr Arg Tyr

35 40 45

Lys Asp He Asn Ala Leu Glu Ala Lys Asn Thr Gin Asn His Ala 50 55 60

(2) INFORMATION FOR SEQ ID NO: 613:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 100 ammo acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...100

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 613 :

Met Leu Glu He Glu Leu Lys Lys Lys Phe Thr Lys Asp Leu Lys Lys

1 5 10 15

His He Leu Asn Gin Lys He Glu Leu Glu Val Phe Asp Leu Val Val 20 25 30

Glu Asn Leu Arg Asn Gin He Pro Leu Asp Lys Arg Phe Lys Asp His

35 40 45

Ala Leu Ser Gly Thr Tyr Lys Gly Cys Arg Glu Arg His He Lys Pro

50 55 60

Asp Val Leu Leu Val Tyr Arg Val Lys Gly Asn Val Leu Thr Leu Val 65 70 75 80

Arg Leu Gly Ser His Ser Glu Leu Phe Cys Lys Pro Pro Thr Pro Leu

85 90 95

He Thr Leu Lys 100

(2) INFORMATION FOR SEQ ID NO: 614:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 646 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_£eature

(B) LOCATION 1...646

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:614:

Ser Asn Tyr Asn Asn Leu Asn Thr Leu Val Ser Leu Ser Ser Asp Pro

1 5 10 15

Ser Ala Val Asn Asp Ala Arg Asp Asn Leu Gly Ser Ser Ala Arg Asn

20 25 30

Leu Leu Asp Val Lys Ala Asn Ser Pro Ala Tyr Gin Ala Val Leu Leu

35 40 45

Ala Leu Asn Ala Ala Val Gly Leu Trp Gin Val Thr Ser Tyr Ala Phe

50 55 60

Thr Ala Cys Gly Pro Gly Ser Asn Glu Asn Ala Asn Gly Gly He Gin 65 70 75 80

Thr Phe Asn Asn Val Pro Gly Gin Asn Thr Thr Thr He Thr Cys Asn

85 90 95

Ser Tyr Tyr Glu Pro Gly His Gly Gly Pro He Ser Thr Glu Asn Tyr

100 105 110

Ala He He Asn Lys Ala Tyr Gin He He Gin Lys Ala Leu Thr Ala

115 120 125

Asn Gly Glu Gly He Pro Val Leu Ser Asn Thr Thr Thr Lys Leu Asp

130 135 140

Phe Thr He Asn Gly Asp Lys Arg Thr Gly Gly Glu Pro Asn Lys Lys 145 150 155 160

Leu Val Tyr Pro Trp Ser His Gly Lys Ala He Ser Thr Ser Trp Asn

165 170 175

Ala Thr He Thr Val Pro Thr Thr Glu Asn He Asn Thr Thr Asn Ser

180 185 190

Ala Gin Glu Leu Leu Lys Gin Ala Ser He He He Thr Thr Leu Asn 195 200 205

Ser Ala Cys Pro Asn Phe Gin Asn Gly Gly Ser Gly Tyr Trp Ala Gly

210 215 220

He Ser Gly Asn Gly Thr Met Cys Gly Met Phe Lys Asn Glu He Ser 225 230 235 240

Ala He Gin Gly Met He Ala Asn Ala Gin Glu Ala Val Ala Gin Ala

245 250 255

Lys He Val Ser Glu Asn Thr Gin Asn Gin Asn Ser Leu Asp Ala Gly

260 265 270

Lys Pro Phe Asn Pro Tyr Thr Asp Ala Ser Phe Ala Glu Ser Met Leu

275 280 285

Lys Asn Ala Gin Ala Gin Ala Glu He Leu Asn Gin Ala Glu Gin Val

290 295 300

Val Lys Asn Phe Glu Lys He Pro Thr Ala Phe Val Asn Asp Ser Leu 305 310 315 320

Gly Val Cys Tyr Glu Val Gin Gly Gly Glu Arg Arg Gly Thr Asn Pro

325 330 335

Gly Gin Thr Thr Ser Asn Thr Trp Gly Ala Gly Cys Ala Tyr Val Gly

340 345 350

Gin Thr He Thr Asn Leu Lys Asn Ser He Ala His Phe Gly Thr Gin

355 360 365

Glu Gin Gin He Gin Gin Ala Glu Asn He Ala Asp Thr Leu Val Asn

370 375 380

Phe Lys Ser Arg Tyr Ser Glu Leu Gly Asn Thr Tyr Asn Ser He Thr 385 390 395 400

Thr Ala Leu Ser Asn He Pro Asn Ala Gin Ser Leu Gin Asn Ala Val

405 410 415

Ser Lys Lys Asn Asn Pro Tyr Ser Pro Gin Gly He Asp Thr Asn Tyr

420 425 430

Tyr Leu Asn Gin Asn Ser Tyr Asn Gin He Gin Thr He Asn Gin Glu

435 440 445

Leu Gly Arg Asn Pro Phe Arg Lys Val Gly He Val Ser Ser Gin Thr

450 455 460

Asn Asn Gly Ala Met Asn Gly He Gly He Gin Val Gly Tyr Lys Gin 465 470 475 480

Phe Phe Gly Gin Lys Arg Lys Trp Gly Ala Arg Tyr Tyr Gly Phe Phe

485 490 495

Asp Tyr Asn His Ala Phe He Lys Ser Ser Phe Phe Asn Ser Ala Ser

500 505 510

Asp Val Trp Thr Tyr Gly Phe Gly Ala Asp Ala Leu Tyr Asn Phe He

515 520 525

Asn Asp Lys Ala Thr Asn Phe Leu Gly Lys Asn Asn Lys Leu Ser Val

530 535 540

Gly Leu Phe Gly Gly He Ala Leu Ala Gly Thr Ser Trp Leu Asn Ser 545 550 555 560

Glu Tyr Val Asn Leu Ala Thr Met Asn Asn Val Tyr Asn Ala Lys Met

565 570 575

Asn Val Ala Asn Phe Gin Phe Leu Phe Asn Met Gly Val Arg Met Asn

580 585 590

Leu Ala Arg Pro Lys Lys Lys Asp Ser Asp His Ala Ala Gin His Gly

595 600 605

He Glu Leu Gly Leu Lys He Pro Thr He Asn Thr Asn Tyr Tyr Ser

610 615 620

Phe Met Gly Ala Glu Leu Lys Tyr Arg Arg Leu Tyr Ser Val Tyr Leu 625 630 635 640

Asn Tyr Val Phe Ala Tyr 645 (2) INFORMATION FOR SEQ ID NO.615:

(i) SEQUENCE CHARACTERISTICS.

(A) LENGTH. 93 ammo acids

(B) TYPE, ammo acid (D) TOPOLOGY, linear

(ii) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...93

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 615 :

Asp Leu Lys Met Leu Thr He Glu Thr Ser Lys Lys Phe Asp Lys Asp

1 5 10 15

Leu Lys He Leu Val^* Lys Asn Gly Phe Asp Leu Lys Leu Leu Tyr Lys

20 25 30

Val Val Gly Asn Leu Ala Thr Glu Gin Pro Leu Glu Pro Lys Tyr Lys

35 40 45

Asp His Pro Leu Lys Gly Ala Leu Lys Asp Phe Arg Glu Cys His Leu

50 55 60

Lys Pro Asp Leu Leu Leu Val Tyr Gin He Lys Lys Gin Glu Asn Thr 65 70 75 80

Leu Phe Leu Val Arg Leu Gly Ser His Ser Glu Leu Phe

85 90

(2) INFORMATION FOR SEQ ID NO: 616:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 81 ammo acids

(D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...81

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 616 :

Arg Ala Trp Arg Met Lys Ser Met Arg Phe Ser Tyr He Glu Pro Arg

1 5 10 15

Ala Lys Tyr Leu He Ser Lys Leu Ser Lys He Trp Val Phe Tyr He 20 25 30

Phe Leu Ser Phe Val Leu He Gly Gly Leu Val Trp Phe Met His Asn

35 40 45

Ala He Lys Arg Ala Gin Asp Asn Ala Ser Ser Leu Thr He Gin Glu

50 55 60

Glu Leu Tyr Arg Cys Tyr He Thr Arg Leu Ser Val Lys Met He He 65 70 75 80

Leu

(2) INFORMATION FOR SEQ ID NO: 617:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 149 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...149

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 617 :

Val Lys Phe Pro Tyr Leu Leu Asn He Arg He Met Leu Tyr Leu Arg

1 5 10 15

Lys Glu Asn Gly Val Arg Thr Leu He Ser Leu Gly He Leu Leu Ser

20 25 30

Val Leu Asn Gly Asp Asp Leu Arg Leu Tyr Ser Lys Pro Leu Val Tyr

35 40 45

Ser Ala Gly Ser Gly He He Gly He Asp He Asp Lys Arg Thr Phe

50 55 60

Tyr Lys Arg Ala Phe Ala Phe Thr Met Lys Ser Leu Phe Gly Glu Asn 65 70 75 80

Leu Leu Leu Phe Val Lys Leu Lys His Ser Ala Leu Met Ser Lys His

85 90 95

Met Lys Gly Pro Leu Glu Asn Arg His His His Ser Phe Ala Lys Asn

100 105 110

Tyr Glu Lys Ala Val Asn Gly Cys Gin Lys Tyr Val His He Lys Leu

115 120 125

Pro Glu Gly Pro Pro Ser Asn Phe Gin Ser Gly Ser Tyr Met Ala Thr

130 135 140

Met Val Met Arg Phe 145

(2) INFORMATION FOR SEQ ID NO: 618:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 159 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear (11) MOLECULE TYPE protein

(m) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE-

(A) ORGANISM- Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...159

( xi ) SEQUENCE DESCRIPTION . SEQ ID NO : 618 :

Val He Thr Asn Gin Gin Asn Glu Val Lys Thr Phe Thr Pro He Glu

1 5 10 15

Thr Lys Lys He Thr Ser Lys Glu Gin Ala Phe Leu Thr Leu Ser Ala

20 25 30

Leu Met Asp Ala Val Glu Asn Gly Thr Gly Ser Leu Ala Arg He Lys

35 40 45

Gly Leu Glu He Ala Gly Lys Thr Gly Thr Ser Asn Asn Asn He Asp

50 55 60

Ala Trp Phe He Gly Phe Thr Pro Thr Leu Gin Ser Val He Trp Phe 65 70 75 80

Gly Arg Asp Asp Asn Thr Pro He Gly Lys Gly Ala Thr Gly Gly Val

85 90 95

Val Ser Ala Pro Val Tyr Ser Tyr Phe Met Arg Asn He Leu Ala He

100 105 110

Glu Pro Ser Leu Lys Arg Lys Phe Asp Val Pro Lys Gly Leu Arg Lys

115 120 125

Glu He Val Asp Lys He Pro Tyr Tyr Ser Ser Pro Asn Ser He Thr

130 135 140

Pro Thr Pro Lys Lys Thr Asp Asp Ser Glu Glu Arg Leu Leu Phe 145 150 155

(2) INFORMATION FOR SEQ ID NO: 619:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 80 ammo acids

(D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...80

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 619:

Leu Leu Leu Asn Leu Lys He Tyr Val Thr Leu Cys Lys He Gin Gly 1 5 10 15 Asp Ser Val Leu Glu Lys Ser Phe Leu Lys Ser Lys Gin Leu Val Leu

20 25 30

Cys Gly Leu Gly Val Phe Met Leu Gin Ala Leu His Phe Ala Gin Thr

35 40 45

Leu His Lys Glu He Leu Phe Tyr Lys Met Cys Leu He Gly Cys Cys

50 55 60

Lys He Ala Ala Ser He Ser Arg Lys Gly Trp He Ala Arg Thr Leu 65 70 75 80

(2) INFORMATION FOR SEQ ID NO: 620:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 344 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...344

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 620 :

Val Lys Cys Gly Lys Lys Gly He Leu Val Ser Thr Arg Lys Ala Met

1 5 10 15

Phe Leu Cys Lys He Pro Leu Ser Leu Thr Leu Met Glu Ala Arg Ser

20 25 30

Val Leu Thr Gin Glu He Arg Ser Phe Leu Pro Glu Thr Thr Thr Ser

35 40 45

Leu Ser Leu Thr He Leu Glu Arg Ser He Cys Cys Leu He Lys Phe

50 55 60

Leu Thr Leu Thr Ser Pro Cys Leu Thr Gin Gin Arg Pro Lys He Asn 65 70 75 80

Ala Thr Asn Asn Asn Val Ser Val Ser Gin Gly Asn Leu Phe He Asn

85 90 95

Ala Ser Cys Val Gin Gin Ser Asp Pro Thr Thr Ala Ser Ala Thr Asn

100 105 110

Pro Cys Thr Thr Ala Gin Asn Asn Ala Ser Ser Ser Asn Ala Ser Asn

115 120 125

Asn Ala Pro He Ala Leu Asn Asn Asn Asp Glu Ser Leu Val Val Thr

130 135 140

Ala Asn Gly Phe Asn Phe Ser Gly Asn He Tyr Ala Asn Gly Val Val 145 150 155 160

Asp Phe Ser Lys He Lys Gly Ser Ala Asn Val Lys Asn Leu Tyr Leu

165 170 175

Tyr Asn Asn Ala Gin Phe Gin Ala Asn Asn Leu Thr He Ser Asn Gin

180 185 190

Ala Val Leu Glu Lys Asn Ala Ser Phe Val Thr Asn Asn Leu Asn He

195 200 205

Gin Gly Ala Phe Asn Asn Asn Ala Thr Gin Lys He Glu Val Leu Gin 210 215 220 Asn Leu Val He Ala Ser Asn Ala Ser Leu Ser Thr Gly He Tyr Gly 225 230 235 240

Leu Glu Val Gly Gly Ala Leu Asn Asn Leu Gly Ala He His Phe Asn

245 250 255

Leu Glu Asn Ser Gin Thr Pro Val Asn Pro Leu He Gin Val Gly Gly

260 265 270

He He Asn Leu Asn Thr Thr Gin Thr Pro Phe Met Asn Val Ser Val

275 280 285

Ala Asn Gly Gly Thr Tyr Thr Leu Leu Lys Ser Ser Arg Tyr He Asp

290 295 300

Tyr Asn He Asn Pro Asn Ser Leu Gin Ser Tyr Leu Lys Leu Tyr Thr 305 310 315 320

Leu He Asn He Asn Gly Asn His He Glu Glu Lys Asn Gly Val Leu

325 330 335

Thr Tyr Leu Gly Gin Arg Val Leu 340

(2) INFORMATION FOR SEQ ID NO: 621:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 266 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...266

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 621 :

Leu Leu Ala Arg Thr He Leu Asp Phe Arg Gly Ser Leu Ser Asn Leu

1 5 10 15

Asn Asn Thr Tyr Asn Ser He Thr Thr Thr Ala Ser Asn Thr Pro Asn

20 25 30

Ser Pro Phe Leu Lys Asn Leu He Ser Gin Ser Thr Asn Pro Asn Asn

35 40 45

Pro Gly Gly Leu Gin Ala Val Tyr Gin Val Asn Gin Ser Ala Tyr Ser

50 55 60

Gin Leu Leu Ser Ala Thr Gin Glu Leu Gly His Asn Pro Phe Arg Arg 65 70 75 80

Val Gly Leu He Ser Ser Gin Thr Asn Asn Gly Ala Met Asn Gly He

85 90 95

Gly Val Gin Val Gly Tyr Lys Gin Phe Phe Gly Glu Lys Arg Arg Trp

100 105 110

Gly Leu Arg Tyr Tyr Gly Phe Phe Asp Tyr Asn His Ala Tyr He Lys

115 120 125

Ser Ser Phe Phe Asn Ser Ala Ser Asp Val Phe Thr Tyr Gly Val Gly

130 135 140

Thr Asp Val Leu Tyr Asn Phe He Asn Asp Lys Thr Thr Lys Asn Ser 145 150 155 160 Lys He Ser Phe Gly Val Phe Gly Gly He Ala Leu Ala Giy Thr Ser

165 170 175

Trp Leu Asn Ser Gin Tyr Val Asn Leu Ala Thr Phe Asn Asn Phe Tyr

180 185 190

Ser Ala Lys Met Asn Val Ala Asn Phe Gin Phe Leu Phe Asn Leu Gly

195 200 205

Leu Arg Met Asn Leu Ala Lys Asn Lys Lys Lys Asp Ser Asp His Ala

210 215 220

Ala Gin His Gly Val Glu Leu Gly Val Lys He Pro Thr He Asn Thr 225 230 235 240

Asn Tyr Tyr Ser Phe Leu Gly Thr Lys Leu Glu Tyr Arg Arg Leu Tyr

245 250 255

Ser Val Tyr Leu Asn Tyr Val Phe Ala Tyr 260 265

(2) INFORMATION FOR SEQ ID NO.622:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 95 ammo acids

(D) TOPOLOGY, linear

(ii) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...95

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 622:

Arg Asn Val Glu Ala Arg Tyr Tyr Tyr Gly Asp Thr Ser Tyr Phe Tyr

1 5 10 15

Leu His Ala Gly Val Leu Gin Glu Phe Ala His Phe Gly Ser Asn Asp

20 25 30

Val Ala Ser Leu Asn Thr Phe Lys He Asn Ala Ala Arg Ser Pro Leu

35 40 45

Ser Thr Tyr Ala Arg Ala Met Met Gly Gly Glu Leu Gin Leu Ala Lys

50 55 60

Glu Val Phe Leu Asn Leu Gly Val Val Tyr Leu His Asn Leu He Ser 65 70 75 80

Asn Ala Ser His Phe Ala Ser Asn Leu Gly Met Arg Tyr Ser Phe 85 90 95

(2) INFORMATION FOR SEQ ID NO: 623:

(l) SEQUENCE CHARACTERISTICS.

(A) LENGTH: 155 ammo acids

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL : YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...155

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 623:

Arg Leu Pro Lys Lys Glu Asp Tyr Ala Lys Ala Met Val Phe Ser Phe

1 5 10 15

Lys Met Glu Ala He Lys Glu Ser Gin He Val Leu Leu He Thr Ser

20 25 30

Ala Phe Glu Gly Gin Phe Glu Lys Thr His Lys Glu Glu Lys Glu Glu

35 40 45

Thr Thr Lys Ser Ala Thr Glu Glu Thr Lys Thr His Asp Ala Ser Leu

50 55 60

Glu Asn He Glu He Arg Asn He Ser Met Leu Leu Asp Val Lys Leu 65 70 75 80

Asn Val Lys Val Arg He Gly Gin Lys Lys Met He Leu Lys Asp Val

85 90 95

Val Ser Met Asp He Gly Ser Val Val Glu Leu Asp Gin Leu Val Asn

100 105 110

Asp Pro Leu Glu He Leu Val Asp Asp Lys Val He Ala Lys Gly Glu

115 120 125

Val Val He Val Asp Gly Asn Phe Gly He Gin He Thr Asp He Gly

130 135 140

Thr Lys Lys Glu Arg Leu Glu Gin Leu Lys Asn 145 150 155

(2) INFORMATION FOR SEQ ID NO: 624:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 211 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...211

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 624 :

Lys Pro Thr Asn Val Trp Ala Asn Ala He Gly Gly Ala Ser Leu Asn

1 5 10 15

Ser Gly Ser Asn Ala Ser Leu Tyr Gly Thr Ser Ala Gly Val Asp Ala

20 25 30

Phe Leu Asn Gly Asn Val Glu Ala He Val Gly Gly Phe Gly Ser Tyr 35 40 45

Gly Tyr Ser Ser Phe Ser Asn Gin Ala Asn Ser Leu Asn Ser Gly Ala

50 55 60

Asn Asn Ala Asn Phe Gly Val Tyr Ser Arg Phe Phe Ala Asn His Pro 65 70 75 80

Glu Phe Asp Phe Glu Ala Gin Gly Ala Leu Gly Ser Asp Gin Ser Ser

85 90 95

Leu Asn Phe Lys Ser Thr Leu Leu Gin Asp Leu Asn Gin Ser Tyr Asn

100 105 110

Tyr Leu Ala Tyr Ser Ala Thr Ala Arg Ala Ser Tyr Gly Tyr Asp Phe

115 120 125

Ala Phe Phe Arg Asn Ala Leu Val Leu Lys Pro Ser Val Gly Val Ser

130 135 140

Tyr Asn His Leu Gly Ser Thr Asn Phe Lys Ser Asn Ser Gin Ser Gin 145 150 155 160

Val Ala Leu Lys Asn Gly Ala Ser Ser Gin His Leu Phe Asn Ala Asn

165 170 175

Ala Thr Trp Lys Arg Val He He Met Gly Thr Leu His Thr Phe He

180 185 190

Cys Met Arg Glu Phe Tyr Lys Ser Ser Leu Thr Leu Asp Arg Met Met

195 200 205

Trp Arg Leu 210

(2) INFORMATION FOR SEQ ID NO: 625:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 343 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...343

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 625 :

His Ala Arg Glu Phe Cys Gin Val Val Met Phe His Lys Ala Leu He

1 5 10 15

Thr Phe He Val Leu Trp Phe Phe Leu Asn Gly Leu Gly Ala Tyr Asp

20 25 30

Phe Lys His Cys Gin Ala Phe Phe Lys Lys Ala Ser Leu Gin Lys Gly

35 40 45

Gly Val Ala Leu Lys Glu Leu Pro Lys Gly Val Tyr Leu Tyr Tyr Ser

50 55 60

Lys Thr Tyr Pro Lys His Ala Lys Val He Lys Ser Asp Pro Phe He 65 70 75 80

Gly Leu Tyr Leu Leu Gin Ser Ala Pro Ser Glu Tyr Val Tyr Thr Leu

85 90 95

Arg Asp Leu Asp Lys Asp Ala Leu He Arg Pro Met Ala Ser He Gly 100 105 110

Ala Asn Gin Ala Thr Glu Ala Arg Leu Leu Val Gly Gin Lys Gly Tyr

115 120 125

Asp Arg Tyr Ala Gin He Ser Gin Lys Thr Gin Lys Asn Gly Val He

130 135 140

Ser Asn He Cys Tyr Gin Met Leu Gly Leu Gly Val Gly Gly Asn Gly 145 150 155 160

Phe He Glu Thr Lys Phe He Lys Arg Phe Leu Asn Gin Gin Glu Pro

165 170 175

Tyr Tyr Gly Asp He Gly Val Arg Leu Glu Glu Arg His Lys Arg Leu

180 185 190

Val Val Ala Gin Phe Asp Pro Phe Phe Pro Lys Asn Pro Phe Leu Lys

195 200 205

Asn Asp Glu He Leu Ala He Asn Asp Tyr Lys He His Ser Leu Ala

210 215 220

Glu Phe Glu Trp Val Val Ser Asn Leu Ser Tyr Gin Ser Leu Ala Lys 225 230 235 240

Val Lys He Lys Arg Asn His Gin He Lys Glu Val Thr Leu Lys Val

245 250 255

Asn Lys Arg Tyr Gly Gly Phe Leu Leu Lys Asp Thr Phe Leu Glu Arg

260 265 270

Tyr Gly He Ala Leu Asp Glu Arg Phe He He Thr Lys He Gly Ala

275 280 285

His Leu Pro Lys Gly Leu Asp Phe Leu Lys Leu Gly Asp Arg He Leu

290 295 300

Trp Val Asn His Arg Ser Val Ser Phe Asn Pro Lys Ala Leu Arg Glu 305 310 315 320

Ala Leu Ser Thr Pro Lys He Glu Leu Leu Val Trp Arg Gin Gly Phe

325 330 335

Glu Phe Tyr He Lys Val Arg 340

(2) INFORMATION FOR SEQ ID NO: 626:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 165 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...165

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 626 :

He Lys He Asn Met Val Glu Cys Gin Asn Leu Leu Ser Ser Cys Gly

1 5 10 15

Lys Asn Leu Asp Asn Lys Glu Leu Gly Met Arg Arg Ser Leu Ala Phe

20 25 30

Cys Leu Leu Ala Leu Leu Gly Leu Gin Val Leu Gly Ala Arg Asp Phe 35 40 45

Ser Gin Leu Lys Asn Glu Glu Leu Leu Lys Leu Ala Gly Thr Leu Pro

50 55 60

Ser Asn Glu Ala He Asp Tyr Arg Met Glu Val Ser Lys Arg Leu He 65 70 75 80

Ala Leu Ser Ala Glu Asp Ala Lys Asn Phe Arg Ala Asn Phe Ser Arg

85 90 95

He Ala Arg Lys Asn Leu Ser Lys Met Ser Glu Glu Asp Phe Lys Lys

100 105 110

Met Arg Glu Glu Val Arg Lys Glu Leu Glu Glu Lys Thr Lys Gly Leu

115 120 125

Ser Ala Glu Glu He Lys Ala Lys Gly Leu Asn Val Ser Val Cys Ser

130 135 140

Gly Asp Thr Arg Lys Val Trp Cys Arg Ala Val Lys Lys Lys Asp Glu 145 150 155 160

His Cys Ser Pro Lys 165

(2) INFORMATION FOR SEQ ID NO: 627:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 157 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...157

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 627 :

Phe Lys Arg Lys Asn Met Lys Lys Ala Leu Lys He Leu Ser Val Gly

1 5 10 15

Ala Leu Leu Phe Val Ala Leu Asn Ala Lys Asp Phe Ser Lys Thr Ser

20 25 30

Asp Glu Asp Leu Ala Lys Met Ala Gly Val Val Ala Pro Gin Asp He

35 40 45

Val Asp Tyr Thr Lys Glu Leu Lys Lys Arg Met Glu Lys Met Pro Glu

50 55 60

Asp Lys Arg Lys Ala Phe His Lys Gin Leu His Glu Tyr Ala Thr Lys 65 70 75 80

Asn Thr Asp Lys Met Thr Val Ala Asp Phe Glu Ala Arg Gin Lys Ala

85 90 95

He Lys Glu Ala Leu Lys Lys Gly Asn Met Glu Asp Met Asp Asp Asp

100 105 110

Phe Gly Leu Arg Ser Cys Lys His Gly Lys Lys His Lys His Asp Lys

115 120 125

His Gly Lys Lys His Gly Lys Lys His Asp Lys Asp His Asp Asp Lys

130 135 140

Asp His Asp His His Asp Glu Asp His Ser Asp Lys His 145 150 155

(2) INFORMATION FOR SEQ ID NO: 628:

(l) SEQUENCE CHARACTERISTICS-

(A) LENGTH. 677 ammo acids

(D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...677

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 628 :

He Gin Arg Tyr Trp Asn Gly Ala Leu Met Lys Asn Gin His Lys Asn

1 5 10 15

Pro Leu Thr Lys Ala Leu Met Lys Thr Tyr Pro Tyr Asn His Phe Leu

20 25 30

Phe Phe Cys Phe He Leu Gly Ala Phe Leu Leu Gly Leu Leu Ser Pro

35 40 45

Ala Tyr Ala Leu Ser He He Thr Thr Lys Glu He Asp Ala Asn Leu

50 55 60

Leu Asn Gly Ala He Glu Ser Arg Val Val Leu Gly Lys Arg Val Phe 65 70 75 80

Lys Val Glu Ala His Gly Phe Tyr Phe Arg Asn Asn Ala Thr Asn Ser

85 90 95

He Asp He Glu He Thr Ser Leu Leu Arg Asp Asn Gin Ser Phe Pro

100 105 110

Leu Thr Ser Ser Ala Lys Thr Ser Leu Lys He Pro Pro Asn Ala Lys

115 120 125

He Lys Lys Ser Thr He Leu Val Leu Lys Gly Glu Asn Ala Glu Glu

130 135 140

Val Ala Lys He Leu Gly Val Ser Lys Glu Glu Tyr Gin Lys Leu Glu 145 150 155 160

Asn He Ala Gin Thr Lys Ala Ala Asn Asp Pro Met Tyr Ala Asn Thr

165 170 175

Pro Phe Ser Asn Gly Ser Asp Ser Ser Phe Tyr Asp Asn Asn Pro Asn

180 185 190

Ser Pro Ser Asn Asn Ala He Asn Gly Lys Asp Gly Ala Asn Gly Ser

195 200 205

Asn Gly Tyr Gly Ala Asn Gly Asn Asp Gly Val Asn Gly He Ser Gly

210 215 220

Ser Asn Gly Ala Asn Gly Ser His Ser Asn Asn Asn Ala He Gly Ser 225 230 235 240

Gly He Asp Thr Asp Gly Val Leu Gly Val Asp Gly Val Asn Gly Ser

245 250 255

Ser Ser Ser Ser Gly Gly Ser Val Gly Gly Tyr Glu Asn Asn Phe Thr

260 265 270

Asn His Gly Ser Thr Asn Asn Asn Thr Gly Gly Tyr Asp Asn Phe Asn 275 280 285

Asn Gly Ser Ser Ser Gly Gly Ser Leu Gly Asn Gly Gly Leu Phe Pro

290 295 300

He Pro Phe Gly Asn Gly Asp Thr Asn Asn Ser Asn Asn Ser Thr Asn 305 310 315 320

Thr Thr Ser Pro Thr Asn Gly Ser Ser Ser Asn Asn Ala Thr Asn Pro

325 330 335

Ser Ser Gin Glu Asn Asn Tyr Ser Ser Gin Tyr Cys Lys Val Pro Glu

340 345 350

Leu Ser Pro Asn Asn Thr Met Lys Leu Asp Val He Ala Lys Asp Gly

355 360 365

Ser Cys He Ser Met Asn Ala Leu Arg Asp Asp Thr Lys Cys Ala Tyr

370 375 380

Arg Tyr Asp Phe Glu Ala Gly Lys Ala He Lys Gin Thr Gin Tyr Tyr 385 390 395 400

Tyr Val Asp Arg Glu Asn Lys Thr Gin Asn He Gly Gly Cys Val Asp

405 410 415

Leu Gin Gly Ala Gin Tyr Ala Met Gin Leu Tyr Lys Asp Asp Ser Lys

420 425 430

Cys Ala Leu Gin Thr Thr Ser Asp Lys Gly Tyr Gly Met Gly Lys Thr

435 440 445

Gin Thr Phe Gin Thr Glu He Val Phe Arg Gly Met Asp Asn Leu He

450 455 460

His Val Ala Val Pro Cys Ser Asp Tyr Ala Arg Val Gin Asp Arg He 465 470 475 480

Val Arg Tyr Glu Lys Asn Asp Lys Thr Gin Thr Leu Thr Pro He Val

485 490 495

Asp Gin Tyr Tyr Asn Asp Pro Asn Asn Pro Asn Lys Gin Glu He Leu

500 505 510

Asn Arg Gly He Ala Thr Gin Leu Ser Ser Gin Tyr Gin Glu Phe Ala

515 520 525

Cys Gly Gin Trp Glu Tyr Asn Asp Ala Lys Leu Glu Ala Lys Arg Pro

530 535 540

Thr Met Leu Lys Ser Tyr Asn Lys Leu Asn Gly Glu Trp Val Glu Val 545 550 555 560

Thr Pro Cys Asn Phe Glu Ala Gly He Lys Ser Gly Ala Val Val Ser

565 570 575

Pro Tyr Val Met Gly Val Pro Ser Ser Lys Val Leu Ser Asp He Thr

580 585 590

Thr Ser His Tyr Phe Arg He Glu Arg Lys Asn Tyr Gly Glu Arg Glu

595 600 605

Gin Cys Gin Lys Leu Tyr Gly Val Asn Arg Cys Gin Pro Gin Tyr Ser

610 615 620

He Leu He Leu Val Ser Pro He Gly Ala Pro Leu Thr Lys Pro Leu 625 630 635 640

Pro Pro Lys Pro Leu Asn Leu He Tyr Ala Gin Pro Lys He Met Lys

645 650 655

Asn Thr Pro Gin Pro He He Leu Ser Pro Leu Lys Pro Pro Ser Thr

660 665 670

Gly Leu Lys Ala Phe 675

(2) INFORMATION FOR SEQ ID NO: 629:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 113 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL : YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...113

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 629:

Met Ala Lys Met Asn Ala Pro Asp Gly Val Ala Val Trp Val Asn Glu

1 5 10 15

Asp Arg Cys Lys Gly Cys Asp He Cys Val Ser Val Cys Pro Ala Gly

20 25 30

Val Leu Gly Met Gly He Glu Lys Glu Arg Val Leu Gly Lys Val Ala

35 40 45

Lys Val Ala Tyr Pro Glu Ser Cys He Gly Cys Val Gin Cys Glu Leu

50 55 60

His Cys Pro Asp Phe Ala He Tyr Val Ala Asp Arg Lys Asp Phe Lys 65 70 75 80

Phe Ala Lys Val Ser Lys Glu Ala Gin Glu Arg Ser Glu Lys Val Lys

85 90 95

Ala Asn Lys Tyr Met Leu Leu Glu Glu Thr He Leu Glu Gly Arg Gly

100 105 110

Lys

(2) INFORMATION FOR SEQ ID NO: 630:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 329 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...329

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 630 :

Met Thr Thr Lys Arg Val Asn Thr Ala Thr Asn Lys He Met Thr Leu

1 5 10 15

Asn Thr Phe Leu Asp Thr Cys Phe Leu Phe Phe He Ser He Leu Phe

20 25 30

Tyr Leu Ser He Pro He Tyr Pro Asn Lys Val Val Val Val Pro Gin 35 40 45

Gly Ser Leu Lys Lys Val Phe Phe Ser Leu Lys Glu Gin Gly Val Asp

50 55 60

He Asn Ala Leu Asp Leu Leu Leu Leu Arg Leu Met Gly Met Pro Lys 65 70 75 80

Lys Gly Tyr He Asp Met Gly Asp Gly Ala Leu Arg Lys Gly Asp Phe

85 90 95

Leu Val Arg Leu He Lys Ala Lys Thr Ala Gin Lys Ser Val Thr Leu

100 105 110

He Pro Gly Glu Thr Arg Tyr Phe Phe Thr Gin He Leu Ser Glu Thr

115 120 125

Tyr Gin Leu Glu Thr Ser Asp Leu Asn Glu Ala Tyr Glu Ser He Ala

130 135 140

Pro Arg Leu Asn Gly Ala Val He Glu Asp Gly Val He Trp Pro Asp 145 150 155 160

Thr Tyr His Leu Pro Leu Gly Glu Asp Ala Phe Lys He Met Gin Thr

165 170 175

Leu He Gly Gin Ser Met Lys Lys His Glu Ala Leu Ser Lys Gin Trp

180 185 190

Leu Gly Tyr Tyr His Lys Glu Glu Trp Phe Glu Lys He He Leu Ala

195 200 205

Ser He Val Gin Lys Glu Ala Ala Asn Val Glu Glu Met Pro Leu He

210 215 220

Ala Ser Val He Phe Asn Arg Leu Lys Lys Gly Met Pro Leu Gin Met 225 230 235 240

Asp Gly Ala Leu Asn Tyr Gin Glu Phe Ser His Ala Lys Val Thr Lys

245 250 255

Glu Arg He Lys Thr Asp Asn Thr Pro Tyr Asn Thr Tyr Lys Phe Lys

260 265 270

Gly Leu Pro Lys Asn Pro Val Gly Ser Val Ser Leu Glu Ala Val Arg

275 280 285

Ala Val Val Phe Pro Lys Lys Thr Asp Phe Leu Tyr Phe Val Lys Met

290 295 300

Pro Asp Lys Lys His Ala Phe Ser Ala Thr Tyr Lys Glu His Leu Lys 305 310 315 320

Asn He Asn He Ser Asn Asn His Phe 325

(2) INFORMATION FOR SEQ ID NO: 631:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 148 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...148

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 631: Lys Phe Met Arg Leu Leu Phe Leu Leu Leu Ser Ala Thr Leu Met Leu

1 5 10 15

Leu Ala Glu Glu Lys He Pro Leu Ser Asp Asp Ala Pro He Lys Leu

20 25 30

Val His Trp Gin Asn Ala Leu Lys Glu Val Gin Pro Asp Ser Asn Ala

35 40 45

Pro Ala Thr Pro Pro He Lys Ala Val Gin Thr Thr Leu Thr Phe Glu

50 55 60

Thr Pro Phe Asn Lys Thr Pro Lys He Met Glu Val Glu Gly Gin Lys 65 70 75 80

Val He Val Leu Lys Asn Ala Gin Leu Asp Ser Lys Lys Thr Met Asp

85 90 95

Phe Lys Glu Ala Ser Leu Asn Ala Leu Glu Met Phe Ser Tyr Gin Asn

100 105 110

Asp He Tyr Leu Leu Ser Lys Lys Ala Lys Ala Gly Leu Glu He Gin

115 120 125

Ala Ser Ser Ser Lys Asp Lys Lys Gin Leu Ala Phe Phe Phe Tyr Pro

130 135 140

Lys Val Phe He 145

(2) INFORMATION FOR SEQ ID NO: 632:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 261 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...261

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 632 :

Glu Leu He Leu Lys Lys Lys Lys Glu Arg Asn Leu Met Lys Lys Gly

1 5 10 15

Ser Leu Ala He Val Leu Gly Ser Leu Leu Ala Ser Gly Thr Phe Tyr

20 25 30

Thr Ala Leu Ala Asp Gly Met Pro Met Lys Gin Gin His Asn Asn Met

35 40 45

Gly Glu Ser Val Glu Leu His Phe His Tyr Pro He Lys Gly Lys Gin

50 55 60

Glu Pro Lys Asn Asn His Leu Val Val Leu He Asp Pro Lys He Glu 65 70 75 80

Ala Asn Lys Val He Pro Glu Asn Tyr Gin Lys Glu Phe Glu Lys Ser

85 90 95

Leu Phe Leu Gin Leu Ser Asn Phe Leu Glu Arg Lys Gly Tyr Ser Val

100 105 110

Ser Gin Phe Lys Asp Val Ser Glu He Pro Gin Asp He Lys Glu Lys 115 120 125

Ala Leu Leu Val Leu Arg Met Asp Gly Asn Val Ala He Leu Glu Asp

130 135 140

He Val Glu Glu Ser Asp Ala Leu Ser Glu Glu Lys Val He Asp Met 145 150 155 160

Ser Ser Gly Tyr Leu Asn Leu Asn Phe Val Glu Pro Lys Ser Glu Asp

165 170 175

He He His Ser Phe Gly He Asp Val Ser Lys He Lys Ala Val He

180 185 190

Glu Arg Val Glu Leu Arg Arg Thr Asn Ser Gly Gly Phe Val Pro Lys

195 200 205

Thr Phe Val His Arg He Lys Glu Thr Asp His Asp Arg Ala He Lys

210 215 220

Lys He Met Asn Gin Ala Tyr His Lys Val Met Ala His He Thr Lys 225 230 235 240

Glu Leu Ser Lys Lys His Met Glu Arg Tyr Glu Lys Val Ser Ser Glu

245 250 255

Met Lys Lys Arg Lys 260

(2) INFORMATION FOR SEQ ID NO: 633:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 268 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...268

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 633:

Asp Gin Lys Phe Lys Gly He He Leu Ala Met Lys He Ser Val Ser

1 ^' 5 10 15

Lys Asn Asp Leu Glu Asn Thr Leu Arg Tyr Leu Gin Ala Phe Leu Asp

20 25 30

Lys Lys Asp Ala Ser Ser He Ala Ser His He His Leu Glu Val He

35 40 45

Lys Glu Lys Leu Phe Leu Lys Ala Ser Asp Ser Asp He Gly Leu Lys

50 55 60

Ser Tyr He Ser Thr Gin Ser Thr Asp Lys Glu Gly Val Gly Thr He 65 70 75 80

Asn Gly Lys Lys Phe Leu Asp He He Ser Cys Leu Lys Asp Ser Asn

85 90 95

He Val Leu Glu Thr Lys Asp Asp Ser Leu Val He Lys Gin Asn Lys

100 105 110

Ser Ser Phe Lys Leu Pro Met Phe Asp Ala Asp Glu Phe Pro Glu Phe

115 120 125

Pro Val He Asp Pro Lys Val Ser Leu Glu He Asn Ala Pro Phe Leu 130 135 140

Val Asp Ala Phe Lys Lys He Ala Pro Val He Glu Gin Thr Ser His 145 150 155 160

Lys Arg Glu Leu Ala Gly Val Leu Met Gin Phe Asn Gin Lys His Gin

165 170 175

Thr Leu Ser Val Val Gly Thr Asp Thr Lys Arg Leu Ser Tyr Thr Gin

180 185 190

Leu Glu Lys He Ser He His Ser Thr Glu Glu Asp He Ser Cys He

195 200 205

Leu Pro Lys Arg Ala Leu Leu Glu He Leu Lys Leu Phe Tyr Glu Asn

210 215 220

Phe Ser Phe Lys Ser Asp Gly Met Leu Ala Val Val Glu Asn Glu Thr 225 230 235 240

His Ala Phe Phe Thr Lys Leu He Asp Gly Asn Tyr Pro Asp Tyr Gin

245 250 255

Lys He Leu Pro Lys Glu Tyr Thr Ser Leu Ser Leu 260 265

(2) INFORMATION FOR SEQ ID NO: 634:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 416 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...416

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 634 :

Asn Pro Leu He Gin Lys Asn Lys Ser Leu Ser He Phe Leu He Ser

1 5 10 15

Asn Ser Val Val Phe Leu Gly Lys He He Leu His Lys Val Phe He

20 25 30

Met Glu Ala Leu Glu Cys Leu Lys Arg He Glu Lys Glu Ser He Gin

35 40 45

Thr He Tyr He Asp Pro Pro Tyr Asn Thr Lys Ser Ser Asn Phe Glu

50 55 60

Tyr Glu Asp Ala His Ala Asp Tyr Glu Lys Trp He Glu Glu His Leu 65 70 75 80

He Leu Ala Lys Ala Val Leu Lys Gin Ser Gly Cys He Phe He Ser

85 90 95

Met Asp Asp Asn Lys Met Ala Glu Val Lys He He Ala Asn Glu He

100 105 110

Phe Gly Thr Arg Asn Phe Leu Gly Thr Phe He Thr Lys Gin Ala Thr

115 120 125

Arg Ser Asn Ala Lys His He Asn He Thr His Glu Tyr Val Leu Ser

130 135 140

Tyr Ala Lys Asn Lys Ala Phe Ala Pro Gly Phe Lys He Leu Arg Thr 145 150 155 160

Leu Leu Pro He Tyr Ala Lys Ala Leu Lys Asp Leu Met Arg Thr He

165 170 175

Lys Asn Val Phe Lys Gin Lys Gly Gin Ala Gin Ala Gin Leu He Leu

180 185 190

Lys Glu Gin He Lys Glu Leu Ser Gin Lys Glu His Phe Asn Phe Leu

195 200 205

Lys Asn Tyr Asn Leu Val Asp Glu Lys Gly Glu He Tyr Phe Ala Lys

210 215 220

Asp Leu Ser Thr Pro Ser Asn Pro Arg Ser Val Ala He Gin Glu He 225 230 235 240

Asn Leu Phe Leu Glu Pro Leu Lys Ser Arg Gly Trp Ser Ser Asp Glu

245 250 255

Lys Leu Lys Glu Leu Tyr Tyr Gin Asn Arg Leu He Phe Lys Asn Asn

260 265 270

Arg Pro Tyr Glu Lys Tyr Tyr Leu Lys Glu Ser Gin Asp Asn Cys Leu

275 280 285

Ser Val Leu Asp Phe Tyr Ser Arg Gin Gly Thr Lys Asp Leu Glu Lys

290 295 300

Leu Gly Leu Lys Gly Leu Phe Lys Thr Pro Lys Pro Val Ala Leu He 305 310 315 320

Lys Tyr Leu Leu Leu Cys Ser Thr Pro Lys Asp Ser He He Leu Asp

325 330 335

Phe Phe Ala Gly Ser Gly Thr Thr Ala Gin Ala Val He Glu Val Asn

340 345 350

Lys Asp Tyr Tyr Leu Asn Trp Ser Phe Tyr Leu Cys Gin Lys Glu Glu

355 360 365

Lys He Lys Asn Asn Pro Gin Ala Val Ser He Leu Lys Asn Lys Gly

370 375 380

Tyr Lys Asn Thr He Ser Asp He Met Leu Leu Arg Leu Glu Lys He 385 390 395 400

He Lys Arg Ser Glu Tyr Glu He Leu Lys Thr Lys Ser He Leu Phe 405 410 415

(2) INFORMATION FOR SEQ ID NO: 635:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 76 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...76

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 635:

Asn Phe Ser Gly Glu Ser Lys Lys Arg Leu Lys His Pro Ala Pro Phe

1 5 10 15

Pro Arg Glu Leu Pro Arg Arg Cys He Gin Leu Phe Ser Phe Leu Glu 20 25 30

Asp Thr He Phe Asp Pro Phe Ser Gly Ser Gly Thr Thr He Leu Glu

35 40 45

Ala Asn Ala Leu Gly Arg Phe Ser Val Gly Leu Glu He Glu Lys Glu

50 55 60

Tyr Cys Glu Leu Phe Lys Lys Arg He Leu Glu Ser 65 70 75

(2) INFORMATION FOR SEQ ID NO: 636:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 217 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...217

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 636 :

Arg Arg Cys Cys Arg Arg Glu Asp Thr Lys Arg Tyr Val He Glu Val

1 5 10 15

Val He Ser Leu Ser Thr Met Thr Ser Leu Leu Ser Ala Glu Thr Pro

20 25 30

Lys Gin Glu Lys Ala He Lys Thr Ser Pro Thr Lys Lys Gly Glu Arg

35 40 45

Asn Ala Ala Phe He Gly He Asp Tyr Gin Leu Gly Met Leu Ser Thr

50 55 60

Thr Ala Gin Asn Cys Ser His Gly Asn Cys Asn Gly Asn Gin Ser Gly 65 70 75 80

Ala Tyr Gly Ser Asn Thr Pro Asn Met Pro Thr Ala Ser Asn Pro Thr

85 90 95

Gly Gly Leu Thr His Gly Ala Leu Gly Thr Arg Gly Tyr Lys Gly Leu

100 105 110

Ser Asn Gin Gin Tyr Ala He Asn Gly Phe Gly Phe Val Val Gly Tyr

115 120 125

Lys His Phe Phe Lys Lys Ala Pro Gin Phe Gly Met Arg Tyr Tyr Gly

130 135 140

Phe Phe Asp Phe Ala Ser Ser Tyr Tyr Lys Tyr Tyr Thr Tyr Asn Asp 145 150 155 160

Tyr Gly Met Arg Asp Ala Arg Lys Gly Ser Gin Ser Phe Met Phe Gly

165 170 175

Tyr Gly Ala Gly Thr Asp Val Leu Phe Asn Pro Ala He Phe Asn Arg

180 185 190

Glu Lys Leu Ala Phe Gly Val Phe Leu Gly Arg Cys Asp Trp Trp His

195 200 205

Leu Leu Gly Ser Asn Lys Leu Leu Phe 210 215 (2) INFORMATION FOR SEQ ID NO.637-

( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH. 107 ammo acids

(D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...107

(xi) SEQUENCE DESCRIPTION. SEQ ID NO: 637:

Gly Gly Val Cys Gly Val Leu Ser Leu Gin Ala His Leu Ser Phe Glu

1 5 10 15

Asn Cys Ser Lys Pro Leu Asp Cys Ser Leu Phe Ala Thr Thr Cys Thr

20 25 30

Pro Gin Asn Pro He Gly Ser Cys Met Val Ser Ser Gin Gly Gly Val

35 40 45

Cys Gly Val Leu Ser Leu Gin Ala His Leu Ser Phe Glu Asn Cys Ser

50 55 60

Lys Pro Leu Asp Cys Ser Leu Phe Ala Thr Thr Cys Thr Pro Gin Asn 65 70 75 80

Pro He Gly Ser Tyr Met Val Ser Ser Gin Gly Gly Val Arg Gly Val

85 90 95

Leu Ser Leu Gin Ala Arg Leu Ser Phe Lys Asn 100 105

(2) INFORMATION FOR SEQ ID NO: 638:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 384 ammo acids

(D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...384

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 638:

Asn Tyr Ser Asn Lys Asp Asn Pro Met Arg Phe Phe Cys Phe Phe Leu 1 5 10 15 Phe Phe Leu Thr Phe Ser Asn Ala Gin He Met Met Thr Phe Asp Ser

20 25 30

Gin Thr Asn Ala Lys Leu Ser Arg Ser Asn Glu Gin Leu Ser Asp Met

35 40 45

Leu Tyr Lys Leu Asn Glu Ser Leu Arg He Tyr Gin Asn Val Leu Ser

50 55 60

Asn Asn Gin Asp Gin Leu Lys Glu He Lys Lys Ala Asn Ser Thr Leu 65 70 75 80

Thr Ser Gin Arg Arg Phe Phe Asn Ala Ser Gin He Arg Leu Met Asp

85 90 95

Thr Asp Ala Leu Leu Lys Gin Ser Ala Leu Glu Leu Glu Lys Leu Gin

100 105 110

Ala Leu Glu Lys His Leu Lys Glu Ser Met Glu His Glu Arg Leu He

115 120 125

Lys Glu Ser Gin Ala Leu Phe Leu Gin Glu His Cys Pro Tyr Leu Ser

130 135 140

Gly Val Lys Asn Leu Glu Glu Ala Ser Asn Ala Leu Glu Val Gin Glu 145 150 155 160

Lys Asn Asn Ala Leu Phe Leu Leu Lys Glu Pro Lys Leu Phe His Leu

165 170 175

Leu Ser Arg Leu Asp Leu Met Ser Ala Leu Asn Ala Leu Cys Asp Gin

180 185 190

Val Leu Glu Asn Glu He Gin Asp Gin Gin Ser His Asn Lys Thr Leu

195 200 205

Glu Tyr Asn Ala Leu Met Asn His Asp Phe Gin Ala Tyr Lys Ala Met

210 215 220

Arg Leu Lys Lys He Lys Asn Lys Leu Gin Ser Gin He Gin Ala Lys 225 230 235 240

Glu Asp Ala Leu Lys Thr Phe Leu Pro Leu Glu Lys Arg Pro Glu Thr

245 250 255

Leu Gly Ser Ser Asp Cys Cys Asp Lys Glu Asn Leu Lys Ser Cys Ala

260 265 270

Asn Gin Leu Gin Gin Arg Tyr Gin Asn Ala Leu He Glu Arg Asp Lys

275 280 285

Glu Leu Lys Asn Ala Lys Asn Asn Lys Glu Lys His Ala Leu He Leu

290 295 300

Ala Asn Tyr Glu His Thr Leu Lys Thr Leu Asn He Glu Phe Leu Ser 305 310 315 320

Glu Leu Ser Glu Gin Met Ala Phe Leu Asn Glu Thr Met Ala Leu Asn

325 330 335

Ala Gin Val Leu Ala Leu Leu Ala Gin Gin Gin Thr Lys Lys Pro Phe

340 345 350

Asn Val Ser Asp Gly Leu Ser Gly Gly Lys Ala Leu He Lys Asn He

355 360 365

Arg Leu Asp Pro His Gly Phe Pro Ser Phe Lys Asn Phe Lys Gin Glu 370 375 380

(2) INFORMATION FOR SEQ ID NO: 639:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 298 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...298

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 639:

Leu Val Phe Lys Lys Pro Phe Phe Lys Asn Arg Leu Leu Asn Val Thr

1 5 10 15

Asn Lys Leu Lys Phe Val Lys He Thr He Met He Lys Asp Phe Asn

20 25 30

His Tyr Cys Arg Lys He Thr Arg Gly Phe Val Lys He Pro Thr Lys

35 40 45

Lys Gin Gly Ala Lys Lys Met Lys Lys Ala Gly Phe Leu Phe Leu Ala

50 55 60

Ala Met Ala He He Val Val Ser Leu Asn Ala Lys Asp Pro Asn Val 65 70 75 80

Leu Arg Lys He Val Phe Glu Lys Cys Leu Pro Asn Tyr Glu Lys Asn

85 90 95

Gin Asn Pro Ser Pro Cys He Glu Val Lys Pro Asp Ala Gly Tyr Val

100 105 no

Val Leu Lys Asp He Asn Gly Pro Leu Gin Tyr Leu Leu Met Pro Thr

115 120 125

Thr His He Ser Gly He Glu Asn Pro Leu Leu Leu Asp Pro Ser Thr

130 135 140

Pro Asn Phe Phe Tyr Leu Ser Trp Gin Ala Arg Asp Phe Met Ser Lys 145 150 155 160

Lys Tyr Gly Lys Pro He Pro Asp Tyr Ala He Ser Leu Thr He Asn

165 170 175

Ser Lys Lys Gly Arg Ser Gin Asn His Phe His He His He Ser Cys

180 185 190

He Ser Leu Asp Val Arg Lys Gin Leu Asp Asn Asn Leu Lys Asn He

195 200 205

Asn Ser Arg Trp Ser Pro Leu Ser Gly Gly Leu Asn Gly His Lys Tyr

210 215 220

Leu Ala Arg Arg Val Thr Glu Ser Glu Leu Ala Gin Lys Ser Pro Phe 225 230 235 240

Val Met Leu Ala Lys Glu Val Pro Asn Ala His Lys Arg Met Gly Asp

245 250 255

Tyr Gly Leu Ala Val Val Gin Gin Ser Asp Asn Ser Phe Val Leu Leu

260 265 270

Ala Thr Gin Phe Asn Pro Leu Thr Leu Asn Arg Ala Ser Ala Glu Glu

275 280 285

He Gin Asp His Glu Cys Ala He Leu Arg 290 295

(2) INFORMATION FOR SEQ ID NO: 640:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 179 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein (in) HYPOTHETICAL. YES

(v ) ORIGINAL SOURCE:

(A) ORGANISM. Helicobacter pylori

(ix) FEATURE-

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...179

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 640-

Leu Arg Arg Leu Ala Leu Asn Thr Met Asn Ser Val Leu Glu Cys Lys

1 10 15

Glu Leu Ala Leu Tyr Gly Gly Ser Phe Asp Pro Leu His Lys Ala His

20 25 30

Leu Ala He He Glu Gin Thr Leu Glu Leu Leu Pro Phe Val Gin Leu

35 40 45

He Val Leu Pro Ala Tyr Gin Asn Pro Phe Lys Lys Pro Cys Phe Leu

50 55 60

Asp Ala Lys Thr Arg Phe Lys Glu Leu Glu Arg Ala Leu Lys Gly Met 65 70 75 80

Pro Arg Val Leu Leu Ser Asp Phe Glu He Lys Gin Glu Arg Ala Val

85 90 95

Pro Thr He Glu Ser Val Leu His Phe Gin Lys Leu Tyr Arg Pro Lys

100 105 110

Thr Leu Tyr Leu Val He Gly Ala Asp Cys Leu Arg His Leu Ser Ser

115 120 125

Trp Thr Asn Ala Lys Glu Leu Leu Lys Arg Val Glu Leu Val Val Phe

130 135 140

Glu Arg He Gly Tyr Glu Lys He Gin Phe Lys Gly Arg Tyr His Pro 145 150 155 160

Leu Lys Gly He Asp Ala Pro He Ser Ser Ser Ala He Arg Ala Ser

165 170 175

Leu Gly Val

(2) INFORMATION FOR SEQ ID NO: 641:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 269 ammo acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi ) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...269

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 641- Ser Ser He Phe Asp Tyr Asn Tyr Lys Gly Leu His Phe Ser Asn Lys

1 5 10 15

Arg Tyr He Met Leu Gly Ser Val Lys Lys Thr Leu Phe Gly Val Leu

20 25 30

Cys Leu Gly Ala Leu Cys Leu Arg Gly Leu Met Ala Glu Pro Asp Ala

35 40 45

Lys Glu Leu Val Ser Leu Gly He Glu Ser Val Lys Lys Gin Asp Phe

50 55 60

Ala Gin Ala Lys Ala His Phe Glu Lys Ala Cys Glu Leu Lys Glu Gly 65 70 75 80

Phe Gly Cys Val Phe Leu Gly Ala Phe Tyr Glu Glu Gly Lys Gly Val

85 90 95

Gly Lys Asp Leu Lys Lys Ala He Gin Phe Tyr Thr Lys Gly Cys Glu

100 105 110

Leu Asn Asp Gly Tyr Gly Cys Arg Leu Leu Gly Asn Leu Tyr Tyr Asn

115 120 125

Gly Gin Gly Val Ser Lys Asp Ala Lys Lys Ala Ser Gin Tyr Tyr Ser

130 135 140

Lys Ser Cys Glu Leu Asn His Ala Glu Gly Cys Thr Val Leu Gly Ser 145 150 155 160

Leu His His Tyr Gly Val Gly Thr Pro Lys Asp Leu Arg Lys Ala Leu

165 170 175

Asp Leu Tyr Glu Lys Ala Cys Asp Leu Lys Asp Ser Pro Gly Cys He

180 185 190

Asn Ala Gly Tyr Met Tyr Gly Val Ala Lys Asn Phe Lys Glu Ala He

195 200 205

Val Arg Tyr Ser Lys Ala Cys Glu Leu Lys Asp Gly Arg Gly Cys Tyr

210 215 220

Asn Leu Gly Val Met Gin Tyr Asn Ala Gin Gly Thr Ala Lys Asp Glu 225 230 235 240

Lys Gin Ala Val Glu Asn Phe Lys Lys Gly Cys Lys Ser Ser Val Lys

245 250 255

Glu Ala Cys Asp Ala Leu Lys Glu Leu Lys He Glu Leu 260 265

(2) INFORMATION FOR SEQ ID NO: 642:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 86 ammo acids

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

( i) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...86

( l ) SEQUENCE DESCRIPTION: SEQ ID NO: 642:

His Phe Asn He Phe Thr Glu Asp Asn Arg Glu He Ser Gly Ser Thr 1 5 10 15 Asp Lys Leu Ser Tyr Asn Ala Leu Asn Gly Glu Tyr Lys Leu Leu Gin

20 25 30

Asn Ala Val Val Arg Glu Val Gly Lys Ser Asn Val He Thr Gly Asp

35 40 45

Glu He He Leu Asn Lys Thr Lys Gly Tyr Ala Asp Val Leu Gly Ser

50 55 60

Ala Lys Arg Pro Leu Asn Leu Cys Leu He Trp Lys Thr Leu Met Lys 65 70 75 80

Lys He Val Arg Leu Asn 85

(2) INFORMATION FOR SEQ ID NO: 643:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 92 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL : YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...92

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 643 :

Pro Lys Ser Pro Lys Lys He Val Lys Arg Tyr Glu Lys Ser Ala Trp

1 5 10 15

Lys Met Pro Lys Glu Asn Thr Thr His Glu Asp Ala Leu Ala Lys Cys

20 25 30

Phe Ala Pro Ala He Phe Lys Ala He Met Leu Asn Lys Leu He Leu

35 40 45

Ala Val Val Ala Ala Pro He He Lys Met Leu Lys Leu Ser Lys Glu

50 55 60

He Trp Trp Lys Lys Met Gly Lys Lys His Ala He Asp Phe Lys Met 65 70 75 80

Arg He Lys He Leu Ala Ser Leu Ala Pro Ser Phe 85 90

(2) INFORMATION FOR SEQ ID NO: 644:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 185 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori ( ix ) FEATURE

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...185

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 644 :

Asn Lys Asp His Leu Met Leu Asn Lys Phe Lys Lys He Val Gly Val

1 5 10 15

Gly Val Leu Val Gly Cys Leu Gly Val Leu Gin Ala Lys Asn Ser Leu

20 25 30

Phe Val Leu Pro Tyr Glu Gin Arg Asp Ala Leu Asn Ser Leu He Ser

35 40 45

Gly He Ser Ser Ala Arg Glu Asn Val Lys He Ala He Tyr Ser Phe

50 55 60

Thr His Arg Asp He Ala Arg Ala He Lys Ser Val Ala Ser Arg Gly 65 70 75 80

He Lys Val Gin He He Tyr Asp Tyr Glu Ser Asn His Asn Asn Lys

85 90 95

Gin Ser Thr He Gly Tyr Leu Asp Lys Tyr Pro Asn Thr Lys Val Cys

100 105 110

Leu Leu Lys Gly Leu Lys Ala Lys Asn Gly Asn Tyr Tyr Gly He Met

115 120 125

His Gin Lys Val Ala He He Asp Asp Lys He Val Phe Leu Gly Ser

130 135 140

Ala Asn Trp Ser Lys Asn Ala Phe Glu Asn Asn Tyr Glu Val Phe Leu 145 150 155 160

Lys Arg Asp Asp Thr Glu Thr He Phe Lys Ala Lys Ser Tyr Tyr Gin

165 170 175

Lys Met Leu Glu Gly Cys Val Gly Phe 180 185

(2) INFORMATION FOR SEQ ID NO: 645:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 215 ammo acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...215

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 645 :

Gly Arg Thr Me t Lys Tyr Leu Trp Leu Phe Leu He Tyr Ala He Gly

1 5 10 15

Leu Phe Ala Thr Asp Lys Thr Leu Asp He He Lys Thr He Gin Lys

20 25 30

Leu Pro Lys He Glu Val Arg Tyr Ser He Asp Asn Asp Ala Asn Tyr 35 40 45

Ala Leu Lys Leu His Glu Val Leu Ala Asn Asp Leu Lys Thr Ser Gin

50 55 60

His Phe Asp Val Ser Gin Asn Lys Glu Gin Gly Ala He Asn Tyr Ala 65 70 75 80

Glu Leu Lys Asp Lys Lys Val His Leu Val Ala Leu Val Ser Val Ala

85 90 95

Val Glu Asn Gly Asn Lys He Ser Arg Leu Lys Leu Tyr Asp Val Asp

100 105 110

Thr Gly Thr Leu Lys Lys Thr Phe Asp Tyr Pro He Val Ser Leu Asp

115 120 125

Leu Tyr Pro Phe Ala Ala His Asn Met Ala He Val Val Asn Asp Tyr

130 135 140

Leu Lys Ala Pro Ser He Ala Trp Met Lys Arg Leu He Val Phe Ser 145 150 155 160

Lys Tyr He Gly Pro Gly He Thr Asn He Ala Leu Ala Asp Tyr Thr

165 170 175

Met Arg Tyr Gin Lys Glu He He Lys Asn Asn Arg Leu Asn He Phe

180 185 190

Pro Lys Trp Ala Asn Ala Glu Gin Thr Glu Phe Tyr Tyr Thr Gin Met

195 200 205

Ala Glu Lys Arg Pro Trp Phe 210 215

(2) INFORMATION FOR SEQ ID NO: 646:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 176 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...176

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 646 :

Ala Ala Met Met Phe Asn Asn Asp H e Asp Ser Ala Thr Gly Phe Tyr

1 5 10 15

Lys Pro Leu He Lys He Asn Ser Ala Gin Asp Leu He Lys Asn Thr

20 25 30

Glu His Val Leu Leu Lys Ala Lys He He Gly Tyr Gly Asn Val Ser

35 40 45

Thr Gly Thr Asn Gly He Ser Asn Val Asn Leu Glu Glu Gin Phe Lys

50 55 60

Glu Arg Leu Ala Leu Tyr Asn Asn Asn Asn Arg Met Asp Thr Cys Val 65 70 75 80

Val Arg Asn Thr Asp Asp He Lys Ala Cys Gly Met Ala He Gly Asn

85 90 95

Gin Ser Met Val Asn Asn Pro Asp Asn Tyr Lys Tyr Leu He Gly Lys 100 105 110

Ala Trp Arg Asn He Gly He Ser Lys Thr Ala Asn Gly Ser Lys He

115 120 125

Ser Val Tyr Tyr Leu Gly Asn Ser Thr Pro Thr Glu Asn Gly Gly Asn

130 135 140

Thr Thr Asn Leu Pro Thr Asn Thr Thr Asn Asn Ala His Ser Ala Asn 145 150 155 160

Tyr Ala Leu Val Lys Asn Ala Pro Phe Ala His Asn Thr Thr Pro Asn 165 170 175

(2) INFORMATION FOR SEQ ID NO: 647:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 188 ammo acids

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...188

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 647 :

He Phe Arg Ala Phe Arg Arg Gly Phe Phe Arg Lys Thr Phe Ala Tyr

1 5 10 15

Arg Phe Thr Ala His His Asp Phe Met Leu Glu Arg Met Asn Arg Arg

20 25 30

Asn Arg Thr Lys Ser Asp Arg Glu Leu Leu Glu He He Ala Ser Lys

35 40 45

Asn Phe Ala He Gly Thr Asp Phe He Val Gly His Pro Gly Glu Ser

50 55 60

Glu Ser Val Phe Glu Lys Ala Phe Lys Asn Leu Glu Ser Leu Pro Leu 65 70 75 80

Thr His He His Pro Phe He Tyr Ser Lys Arg Lys Asp Thr Pro Ser

85 90 95

Ser Leu Met Arg Asp Ser Val Ser Leu Glu Asp Ser Lys Lys Arg Leu

100 105 110

Asn Ala He Lys Asp Leu He Phe His Lys Asn Lys Ala Phe Arg Gin

115 120 125

Leu Gin Leu Lys Leu Asn Thr Pro Leu Lys Ala Leu Val Glu Ala Gin

130 135 140

Lys Asp Gly Glu Phe Lys Ala Leu Asp Gin Phe Phe Asn Pro He Lys 145 150 155 160

He Lys Ser Asp Lys Pro Leu Arg Ala Ser Phe Leu Glu He Lys Glu

165 170 175

Tyr Glu He Lys Glu Arg Glu Asn His Ala Val Phe 180 185

(2) INFORMATION FOR SEQ ID NO: 648: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 79 ammo acids (3) TYPE: ammo acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...79

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 648:

Lys Ala Leu Pro Gin Gly Arg Asn Arg Met Arg Ser Asp Val Glu Val

1 5 10 15

Leu Ser Pro Leu His Lys He Asp Glu Lys Tyr Leu Phe His Leu Lys

20 25 30

He Ala Gly Glu Leu Ala Ser Met Gly Lys He Leu Ser Val Tyr Leu

35 40 45

Ala His Lys His Ser Ala Tyr Phe He Leu Asn Ala Leu Ser Tyr Gly

50 55 60

Phe Ser His Gin Asp Arg Ala He He Cys Leu Leu Gly Ala He 65 70 75

(2) INFORMATION FOR SEQ ID NO: 649:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 235 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL : YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...235

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 649:

Lys Gly Thr Lys Met Lys Lys Val Tyr Phe Lys Thr Phe Gly Cys Arg

1 5 10 15

Thr Asn Leu Phe Asp Thr Gin Val Met Gly Glu Asn Leu Lys Asp Phe

20 25 30

Ser Ala Thr Leu Glu Glu Gin Glu Ala Asp He He He He Asn Ser

35 40 45

Cys Thr Val Thr Asn Gly Thr Asp Ser Ala Val Arg Ser Tyr Ala Arg 50 55 60 Lys Met Ala Arg Leu Asp Lys Glu Val Leu Phe Thr Gly Cys Gly Val 65 70 75 80

Lys Thr Gin Gly Lys Glu Leu Phe Glu Lys Gly Leu Leu Lys Gly Val

85 90 95

Phe Gly His Asp Asn Lys Glu Lys He Asn Ala Leu Leu Gin Glu Lys

100 105 110

Lys Arg Phe Phe He Asp Asp Asn Leu Glu Asn Lys His Leu Asp Thr

115 120 125

Thr Met Val Ser Glu Phe Val Gly Lys Thr Arg Ala Phe He Lys He

130 135 140

Gin Glu Gly Cys Asp Phe Asp Cys Asn Tyr Cys He He Pro Ser Val 145 150 155 160

Arg Gly Arg Ala Arg Ser Phe Glu Lys Arg Lys He Leu Glu Gin Val

165 170 175

Gly Leu Leu Cys Ser Gin Gly Val Gin Glu Val Val Leu Thr Gly Thr

180 185 190

Asn Val Gly Ser Tyr Gly Lys Asp Arg Gly Ser Asn He Ala Arg Leu

195 200 205

He Lys Lys Leu Ser Gin He Thr Gly Leu Lys Arg He Arg He Gly

210 215 220

Ser Leu Asp Leu He Lys Ser Thr Met Asn Phe 225 230 235

(2) INFORMATION FOR SEQ ID NO: 650:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 101 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL : YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...101

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 650 :

Val Thr Ala Leu Ala Thr Arg He Gly Arg Ser Phe Ala Tyr Trp Ala

1 5 10 15

Gin Phe Ser His Lys Lys He Leu Lys Asp Tyr Val He Ala His Met

20 25 30

Ser Ala Met Met Pro Ser Leu Leu Thr Leu Gin Trp Leu Ser Phe He

35 40 45

Leu Ser Leu Ala Glu Asn Leu Cys Leu Thr Asp Ser His His Leu Lys

50 55 60

Tyr Thr Leu Glu Lys Asn Lys Leu Val He His Ser Asn Asp Ala Leu 65 70 75 80

Tyr Leu Ala Lys Glu Met Leu Pro Lys Leu He Lys Pro He Pro Trp

85 90 95

Thr He Glu Phe Ala 100 (2) INFORMATION FOR SEQ ID NO- 651

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH. 409 ammo acids

(B) TYPE ammo acid (D) TOPOLOGY, linear

(ii) MOLECULE TYPE, protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE-

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...409

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 651 :

Ser Asp Ala Phe Leu He He Gin Asp Phe Lys Glu Gin Arg He He

1 5 10 15

His Lys He He Gin Thr His Phe Lys Arg Met Arg Val Val Leu Ser

20 25 30

Val Lys Arg Asp Ser Glu Lys Thr Leu Glu Asn Asn Glu Glu Asn Lys

35 40 45

Asp Glu Lys Leu He Leu He Asp Glu Phe Glu Val Leu Ala Asn Lys

50 55 60

Phe He Ser Arg Leu Pro Asn He Pro Ser Thr Pro Arg Glu Phe Gly 65 70 75 80

Leu Gly Lys Gly Glu He Met Glu He Asp Val Pro Phe Gly Ser He

85 90 95

Phe Ala Tyr Arg His He Gly Ser He Arg Gin Lys Glu Tyr Arg He

100 105 110

Val Gly Leu Tyr Arg Asn Asp Val Leu Leu Leu Ser Thr Lys Ser Leu

115 120 125

Val He Gin Pro Arg Asp He Leu Leu Val Ala Gly Asn Pro Glu He

130 135 140

Leu Asn Ala Val Tyr His Gin Val Lys Ser Asn Val Gly Gin Phe Pro 145 150 155 160

Ala Pro Phe Gly Lys Ser He Tyr Leu Tyr He Asp Met Arg Leu Gin

165 170 175

Ser Arg Lys Ala Met Met Arg Asp Val Tyr Gin Ala Leu Phe Leu His

180 185 190

Lys Arg Leu Lys Ser Tyr Lys Leu Tyr He Gin Val Leu His Pro Thr

195 200 205

Ser Pro Lys Phe Tyr His Lys Phe Leu Ser Leu Glu Thr Glu Ser He

210 215 220

Glu Val Asn Phe Asp Phe Tyr Gly Lys Ser Phe He Gin Lys Leu His 225 230 235 240

Glu Asp His Gin Lys Lys Met Gly Leu He Val Val Gly Arg Glu Leu

245 250 255

Phe Phe Leu Lys Lys His Arg Arg Ala Leu His Lys Thr Ala Thr Pro

260 265 270

Val Tyr Lys Thr Asn Thr Ser Gly Leu Ser Lys Thr Thr Gin Ser He 275 280 285 Val Val Leu Asn Glu Ser Leu Ser He Asn Glu Asp Met Ser Ser Val

290 295 300

He Phe Asp Val Ser Met Gin Met Asp Leu Gly Leu Leu Leu Tyr Asp 305 310 315 320

Phe Asp Pro Asn Lys His Tyr Lys Asn Glu He Val Asn His Tyr Glu

325 330 335

Asn Leu Ala Asn Thr Phe Asn Arg Lys He Glu He Phe Gin Thr Asp

340 345 350

He Lys Asn Pro He Met Tyr Leu Asn Ser Leu Arg Asn Pro He Leu

355 360 365

His Phe Met Pro Phe Glu Glu Cys He Thr Gin Thr Arg Tyr Leu Trp

370 375 380

Phe Leu Ser Thr Lys Val Glu Lys Leu Ala Phe Leu Asn Asp Asp His 385 390 395 400

Pro Gin He Phe He Pro Val Ala Glu 405

(2) INFORMATION FOR SEQ ID NO: 652:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 64 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...64

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 652 :

Pro Asn Glu Ala Ser Ala Ala Val Asn Val Gly Tyr Lys He Ser Lys

1 5 10 15

Ser Leu Thr Ala Ser Val Lys Leu Glu Tyr Leu Gly Val Met Thr His

20 25 30

Ser Gly Phe Thr Val Gly Ser Tyr Arg Pro Thr Pro Gly Ser Lys Ala

35 40 45

Leu Tyr Ser Asp Arg Ser His Leu Met Thr Thr Leu Ser Ala Lys Val 50 55 60

(2) INFORMATION FOR SEQ ID NO: 653:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 85 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...85

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 653 :

Ser He Val Tyr Gly Lys Asn Lys Leu Phe Ser Asp Glu Phe Tyr Glu

1 5 10 15

Lys He Glu Asp He Leu Thr Asn Asn Asn Pro Arg Tyr Lys Gin Val

20 25 30

Cys He He Phe Asp Ala Asp He Lys Lys Glu Asn Gin Glu Ser Asp

35 40 45

Ala Gly Phe Asp Asn Lys Leu Lys His He Arg Glu Lys Phe Lys Glu

50 55 60

Lys Gly Thr Asp Phe Pro Lys Glu Gin He Phe Tyr Ser Leu Thr He 65 70 75 80

Lys Met Met Ala He 85

(2) INFORMATION FOR SEQ ID NO: 654:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 146 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...146

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 654 :

Val Gin Ala Phe Asp Tyr Lys He Glu Val Leu Ala Glu Ser Phe Ser

1 5 10 15

Lys Val Gly Phe Asn Lys Lys Lys He Asp He Ala Arg Gly He Tyr

20 25 30

Pro Thr Glu Thr Phe Val Thr Ala Val Gly Gin Gly Asn He Tyr Ala

35 40 45

Asp Phe Leu Ser Lys Ser Leu Lys Asp Gin Gly His Val Leu Glu Gly

50 55 60

Lys Val Gly Gly Thr He Gly Gly He Ala Tyr Asp Ser Thr Lys Phe 65 70 75 80

Asn Gin Gly Gly Ser Val He Tyr Asn Tyr He Gly Tyr Trp Asp Gly

85 90 95

Tyr Leu Gly Gly Lys Arg Ala Leu Leu Asp Gly Thr Ser He His Glu

100 105 110

Cys Ala Leu Gly Ser Asp Gly Lys Val He Asp Ser He Ala Cys Gly 115 120 125

Asn Ala Arg Ala Asn Lys He Arg Arg Asn Tyr Leu Met Asn Thr Pro

130 135 140

Phe Ser 145

(2) INFORMATION FOR SEQ ID NO: 655:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 247 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL : YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...247

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 655 :

Phe Arg Tyr Lys Asp He Phe Ala Ala Lys Gly Gly Arg Tyr Gin Ser

1 5 10 15

Asn Ala Pro Tyr Met Ser Ser Tyr Thr Gin Gly Phe Glu He Ser Ala

20 25 30

Lys He Lys Asp Lys Asn Glu Gly Ser His Lys Leu Trp Trp Phe Ser

35 40 45

Ser Trp Gly Arg Ala Phe Ala Tyr Gly Glu Trp He Tyr Asp Phe Tyr

50 55 60

Ser Pro Arg Thr Val He Lys Asn Gly Arg Thr Leu Asn Tyr Gly He 65 70 75 80

His Leu Val Asp Tyr Thr Tyr Glu Arg Lys Gly Val Ser Val Ser Pro

85 90 95

Phe Phe Gin Phe Ser Pro Gly Thr Tyr Tyr Ser Pro Gly Val Ala Val

100 105 110

Gly Tyr Asp Ser Asn Pro Asn Phe Asn Gly Val Gly Phe Arg Ser Glu

115 120 125

Thr Lys Ala Tyr He Leu Leu Pro Val His Ala Pro Leu Lys Arg Asp

130 135 140

Thr Tyr Arg Tyr Ala Val Lys Ala Gly Thr Ala Gly Gin Ser Leu Leu 145 150 155 160

He Arg Gin Arg Phe Asp Tyr Asn Glu Phe Asn Phe Gly Gly Ala Phe

165 170 175

Tyr Lys Val Trp Lys Asn Ala Asn Ala Tyr He Gly Thr Thr Gly Asn

180 185 190

Pro Leu Gly He Asp Phe Trp Thr Asn Ser Val Tyr Asp He Gly Gin

195 200 205

Ala Leu Ser His Val Val Thr Ala Asp Ala Val Ser Gly Trp Val Phe

210 215 220

Gly Gly Gly Val His Lys Lys Trp Leu Trp Gly Thr Leu Trp Arg Trp 225 230 235 240

Thr Ser Gly Ala Leu Ala Lys 245 (2) INFORMATION FOR SEQ ID NO: 656:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 130 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL : YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...130

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 656:

Phe Ser Gin Arg Thr Asn Leu Leu Phe Pro Asn Asn Gin Asp Asp Gly

1 5 10 15

Asp Leu Glu Thr Leu Leu Leu Glu He Ala Lys His Asp Glu Phe Leu

20 25 30

Lys Cys Phe Glu Gly Tyr Leu Glu Cys He Lys Ser Lys Glu His Tyr

35 40 45

Lys Pro He Lys Asn He Arg Lys Asn Met Leu Tyr Ala Tyr Leu Glu

50 55 60

Ala Leu Gly Leu Glu Asn Leu Thr Lys Thr Asn He Asp Val Phe Asp ,65 70 75 80

Ser Lys Gly Lys He Lys Ser Arg Tyr Glu Glu Asn Tyr Lys Lys Leu

85 90 95

Thr Glu Glu Val He Asp Phe Ser Ser Asn Ser Leu He Pro Leu Lys

100 105 110

Asn Phe Leu Gly Gin Phe Ala Glu Asn Lys Gin Lys Thr Asn Pro Lys

115 120 125

He Phe 130

(2) INFORMATION FOR SEQ ID NO: 657:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 71 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature ( B ) LOCATION 1 . . . 71

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 657 :

He Tyr Phe Ser Ala Lys Arg Phe Asn Thr Lys Asn Thr Hi s Gly Thr

1 5 10 15

Gly Cys Thr Leu Ser Ser Leu He Val Gly Leu Leu Ala Gin Gly Leu

20 25 30

Asp Leu Lys Asn Ala He Thr Lys Ala Lys Glu Leu Leu Thr He He

35 40 45

He Gin Asn Pro Leu Asn He Gly His Gly His Gly Pro Leu Asn Leu

50 55 60

Trp Ser He Lys Lys His Val 65 70

(2) INFORMATION FOR SEQ ID NO: 658:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 233 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...233

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 658:

Arg Pro Ser Phe Gin Lys Arg Cys Ala His Phe Asn Ala Thr Leu Pro

1 5 10 15

He Leu Leu Lys Val Leu Glu Lys Gin Asp Lys Asp Leu Phe Leu Leu

20 25 30

Gin Val Gly Asn Arg He He Pro Thr Lys Ser Glu Gin Glu Leu Lys

35 40 45

He Asn Gin Pro Tyr Phe Ala Thr Met Gin Arg Asn Gin Leu Gly Asp

50 55 60

He Val Leu Lys Asn Leu Val Pro Ala Pro Lys He Leu Asp Ala Leu 65 70 75 80

Asp Asp Leu Pro Val He Glu Met Lys Lys Leu Lys Glu He Leu Ser

85 90 95

Ala Lys Asp Asn Thr Pro Leu Lys Glu Tyr Lys Glu Leu Leu Ser Glu

100 105 110

Lys Leu He His Ala Lys Ser Ser Gin Glu Phe Leu Asn Thr Ala Asn

115 120 125

Met Leu Leu Ser Leu Gin Ser Gin Val Leu Ser Phe Val Val Glu Asn

130 135 140

Glu Arg Lys Lys Ala Phe Leu Gin Met Lys Ala Lys Lys Gin Ser Val 145 150 155 160

Asp Phe Tyr Ala Leu Tyr Pro Asn Leu Gly Glu He Gly Gly Val He 165 170 175 Tyr Leu Lys Glu Lys Glu Lys Gin Leu Phe Leu Lys Thr Thr Leu Gin

180 185 190

Arg Thr Lys Glu Val Leu Lys Glu Ala Gin Asn Thr Leu Leu Gly Phe

195 200 205

Ser Phe Val Glu He Val Cys Glu Lys Thr Pro Met Leu Phe Ala Phe

210 215 220

Glu Asp Arg Leu Leu Asp Thr Leu Gly 225 230

(2) INFORMATION FOR SEQ ID NO: 659:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 154 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...154

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 659 :

Leu Leu Glu Met He Phe Arg Ser Arg Arg Ser Lys Trp Gly Ala Leu

1 5 10 15

Cys Asn Ala Gin He He Glu Cys Val Ala Asn Ala Leu Glu Thr Cys

20 25 30

Asp Phe Gly Leu Cys Val Leu Asp Pro Val Met Val Ala Lys Asn Gly

35 40 45

Ala Leu Leu Leu Glu Glu Glu Ala He Leu Ser Leu Lys Lys Arg Leu

50 55 60

Leu Pro Lys Thr Asn Leu Leu Thr Pro Asn Leu Pro Glu Val Tyr Ala 65 70 75 80

Leu Thr Gly Val Gin Ala Arg Asp Asp Lys Ser Ala Ser Lys Ala Met

85 90 95

Gly Val Leu Arg Asp Leu Gly Val Lys Asn Ala Val He Lys Gly Gly

100 105 110

His Thr Glu His Phe Gin Gly Glu Phe Ser Asn Asp Trp Val Phe Leu

115 120 125

Glu Asp Ala Glu Phe Thr Leu Ala Pro Ser Asp Ser Thr Pro Lys Thr

130 135 140

Arg Met Ala Arg Val Val Leu Cys Leu Ala 145 150

(2) INFORMATION FOR SEQ ID NO: 660:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 323 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear (11) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...323

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 660:

Trp Leu Gin Ser Arg Cys Phe Arg Asp Ser Ala Phe Cys Leu Ser Ser

1 5 10 15

Glu Lys Leu Phe Gly Lys Asn Leu Asn Lys Val Val He Leu Ala Leu

20 25 30

Arg Asp He He His Glu Tyr Gly His Thr Leu Gly Tyr Thr His Asn

35 40 45

Gly Asn Met Thr Tyr Gin Arg Val Arg Leu Cys Gin Glu Gly Asn Gly

50 55 60

Pro Glu Ala Arg Cys Glu Gly Gly His Glu Val Glu Lys Asn Gly Lys 65 70 75 80

Glu Glu Leu Glu Phe Ser Asn Gly His Glu Val Arg Asp His Asp Gly

85 90 95

Tyr Thr Tyr Asp Val Cys Ser Arg Phe Gly Gly Lys Asn Gin Pro Ala

100 105 110

Phe Pro Ser Asn Tyr Pro Asn Ser He Tyr Thr Asn Cys Ala Gin Val

115 120 125

Pro Ala Gly Leu He Gly Val Thr Thr Ala Val Trp Gin Gin Leu He

130 135 140

Asn Gin Asn Ala Leu Pro He Asn Phe Ala Asn Leu Asn Ser Gin Thr 145 150 155 160

Ser His Leu Asn Ala Gly Leu Asn Ala Gin Asn Phe Ala Thr Ser Met

165 170 175

Val Ser Ala He Ala Gin Asn Phe Ser Thr Thr Ser Thr Thr Thr Tyr

180 185 190

Arg Ser Ser Ser Lys Asn Phe Arg Ser Pro He Leu Gly Val Asn Val

195 200 205

Lys He Gly Tyr Gin His Tyr Phe Asn Asp Tyr He Gly Leu Ala Tyr

210 215 220

Tyr Gly He He Gin Tyr Asn Tyr Ala Gin Ala Asn Asp Glu Lys He 225 230 235 240

Gin Gin Leu Ser Tyr Gly Gly Gly Met Asp Val Leu Phe Asp Phe He

245 250 255

Thr Thr Tyr Thr Asn Lys Lys Gin Asp His Pro Thr Lys Lys Val Phe

260 265 270

Ala Ser Ser Phe Gly Val Phe Gly Gly Leu Arg Gly Leu Tyr Asn Ser

275 280 285

Tyr Tyr Val Phe Asn Gin Val Lys Gly Ser Gly Asn Leu Asp He Val

290 295 300

Thr Gly Phe Asn Tyr Arg Tyr Lys His Ser Lys Tyr Ser He Ala Leu 305 310 315 320

Ala Phe Leu

(2) INFORMATION FOR SEQ ID NO: 661: ( ) SEQUENCE CHARACTERISTICS.

(A) LENGTH- 142 ammo acids

(D) TOPOLOGY- linear

(ii) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...142

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 661:

Tyr Asp Phe Leu Gly Val Ser Leu His Ala Leu Ser Pro Leu Glu Glu

1 5 10 15

Gin Glu Phe Leu He Ser Tyr Arg Leu Lys He Val Asp Ser Arg Val

20 25 30

Met Gly Glu Glu Tyr Ser Val Ser Lys Pro He Val Ser Arg He Lys

35 40 45

Thr Ala Pro Tyr Val Leu Asp Tyr His Cys Ser He He Thr Arg Asn

50 55 60

Leu Pro Asp Leu Lys Asn Pro Leu Leu Gin He Lys Leu Glu Arg Phe 65 70 75 80

Leu Leu Glu He Ala Leu Lys Lys Glu Lys Glu Arg Val He Asp Cys

85 90 95

Leu Leu Lys Ser Gin Val Ala He Thr His Tyr Asp His Ser Tyr Lys

100 105 110

Asn Gly Thr Thr Thr Thr Ser He Leu Asn Leu Lys Ala Leu Ser Val

115 120 125

Lys Ala Ser Leu Asp Gly Arg Tyr Ala Val Phe Arg Tyr Phe 130 135 140

(2) INFORMATION FOR SEQ ID NO: 662:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 344 ammo acids

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...344

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 662: Glu Trp Leu Met Leu Lys Lys He Phe Tyr Gly Phe He Val Leu Phe

1 5 10 15

Leu He He Val Gly Leu Leu Ala Val Leu Val Ala Gin Val Trp Val

20 25 30

Thr Thr Asp Lys Asp He Ala Lys He Lys Asp Tyr Arg Pro Ser Val

35 40 45

Ala Ser Gin He Leu Asp Arg Lys Gly Arg Leu He Ala Asn He Tyr

50 55 60

Asp Lys Glu Phe Arg Phe Tyr Ala Arg Phe Glu Glu He Pro Pro Arg 65 70 75 80

Phe Val Glu Ser Leu Leu Ala Val Glu Asp Thr Leu Phe Phe Glu His

85 90 95

Gly Gly He Asn Leu Asp Ala Val Met Arg Ala Met He Lys Asn Ala

100 105 110

Lys Ser Gly Arg Tyr Thr Glu Gly Gly Ser Thr Leu Thr Gin Gin Leu

115 120 125

Val Lys Asn Met Val Leu Thr Arg Glu Lys Thr Leu Thr Arg Lys Leu

130 135 140

Lys Glu Ala He He Ser He Arg He Glu Lys Val Leu Ser Lys Glu 145 150 155 160

Glu He Leu Glu Arg Tyr Leu Asn Gin Thr Phe Phe Gly His Gly Tyr

165 170 175

Tyr Gly Val Lys Thr Ala Ser Leu Gly Tyr Phe Lys Lys Pro Leu Asp

180 185 190

Lys Leu Thr Leu Lys Glu He Thr Met Leu Val Ala Leu Pro Arg Ala

195 200 205

Pro Ser Phe Tyr Asp Pro Thr Lys Asn Leu Glu Phe Ser Leu Ser Arg

210 215 220

Ala Asn Asp He Leu Arg Arg Leu Tyr Ser Leu Gly Trp He Ser Ser 225 230 235 240

Asn Glu Leu Lys Ser Ala Leu Asn Glu Val Pro He Val Tyr Asn Gin

245 250 255

Thr Ser Thr Gin Asn He Ala Pro Tyr Val Val Asp Glu Val Leu Lys

260 265 270

Gin Leu Asp Gin Leu Asp Gly Leu Lys Thr Gin Gly Tyr Thr He Lys

275 280 285

Leu Thr He Asp Leu Asp Tyr Gin Arg Leu Ala Leu Glu Ser Leu Arg

290 295 300

Phe Gly His Gin Lys He Leu Glu Lys He Ala Lys Glu Lys Pro Lys 305 310 315 320

Thr Asn Ala Ser Asn Asp Lys Asp Glu Asp Asn Leu Asn Ala Gin His

325 330 335

Asp Ser Tyr Arg Asn Glu His Arg 340

(2) INFORMATION FOR SEQ ID NO: 663:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 117 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE

(A) ORGANISM Helicobacter pylori

(ix) FEATURE

(A) NAME/KEY mιsc_feature

(B) LOCATION 1 .117

( xi ) SEQUENCE DESCRI PTION - SEQ ID NO - 663

Thr Pro Ser Met He Val Thr Glu Thr Ser Thr Gly Lys He Leu Ala

1 5 10 15

Leu Val Gly Gly He Asp Tyr Lys Lys Ser Ala Phe Asn Arg Ala Thr

20 25 30

Gin Ala Lys Arg Gin Phe Gly Ser Ala He Lys Pro Phe Val Tyr Gin

35 40 45

He Ala Phe Asp Asn Gly Tyr Ser Thr Thr Ser Lys He Pro Asp Thr

50 55 60

Ala Arg Asn Phe Glu Asn Gly Asn Tyr Ser Lys Asn Ser Val Gin Asn 65 70 75 80

His Ala Trp His Pro Ser Asn Tyr Thr Arg Lys Phe Leu Gly Leu Val

85 90 95

Thr Leu Gin Glu Ala Leu Ser His Ser Leu Asn Leu Ala Thr He Asn

100 105 110

Leu Ala He Ala Trp 115

(2) INFORMATION FOR SEQ ID NO: 664:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 208 ammo acids

(B) TYPE: ammo acid (D) TOPOLOGY, linear

(n) MOLECULE TYPE: protein

(m) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...208

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 664.

Pro Arg Asp His Thr Tyr Ser Leu Glu Asp Ser Thr Pro His Gly Ser

1 5 10 15

Leu Leu Gly Arg Asn Gly Val Thr Leu Asn He Arg Gin Val Phe Trp

20 25 30

Trp Asp Asn Phe Asn Trp Ser He Gly Phe Tyr Asn Thr Phe Gly Asn

35 40 45

Ser Asp Ala Phe Leu Gly Ser His Thr Met Pro Arg Gly Asn Asn Thr

50 55 60

Ser Tyr He Ser Asn Glu He Ser Val Thr Thr Arg His Ala Gly Met 65 70 75 80

He Gly Tyr Asp Phe Trp Asp Asn Thr Ala Tyr Asp Gly Leu Ala Asp 85 90 95

Ala He Thr Asn Ala Asn Thr Phe Thr Phe Tyr Thr Ser Val Gly Gly

100 105 110

He His Lys Arg Phe Ala Trp His Val Phe Gly Arg Val Ser His Ala

115 120 125

Asn Lys Asn Ala Leu Gly Gin Val Gly Arg Ala Asn Glu Tyr Ser Leu

130 135 140

Gin Phe Asn Ala Ser Tyr Ala Ser Thr Glu Ser Val Leu Leu Asn Phe 145 150 155 160

Arg He Thr Tyr Tyr Gly Ala Arg He Asn Lys Gly Tyr Gin Ala Gly

165 170 175

Tyr Phe Gly Ala Pro Lys Phe Asn Asn Pro Asp Gly Asp Phe Ser Ala

180 185 190

Asn Tyr Gin Asp Arg Ser Tyr Met Met Thr Asn Leu Thr Leu Lys Phe 195 200 205

(2) INFORMATION FOR SEQ ID NO: 665:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 132 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...132

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 665 :

Pro Arg He His Asp Met Gly Asp Leu Asp Ser Leu Asn He Ser Pro

1 5 10 15

Asp Pro Asn Thr Pro Thr Leu Leu He Leu Ser Ala Leu Asp Asn Ser

20 25 30

Leu Lys Asp Tyr Ala Pro Thr Phe Asn Val Leu Lys Lys Thr Phe Lys

35 40 45

Asp Arg Leu Arg Val Leu He Leu Leu Asn Gin Pro Tyr Ser Ser Asp

50 55 60

Ala He Lys Gly Phe He Ala Pro Ser Gin Thr Asp Leu Met He Leu 65 70 75 80

Asn Pro Lys Asp Thr Ala Leu Phe Asp His Leu Asn His Asp Ala Leu

85 90 95

Asn His Ser Phe Asn Met Leu Leu Tyr Asp Lys His Gin Leu He Lys

100 105 110

Met Tyr Gin Gly He Val Pro Ala Glu Met Leu Gin Phe Asp He Ser

115 120 125

Asn Leu Lys Asp 130

(2) INFORMATION FOR SEQ ID NO: 666: (i) SEQUENCE CHARACTERISTICS.

(A) LENGTH: 122 ammo acids

(B) TYPE, ammo acid (D) TOPOLOGY, linear

(ii) MOLECULE TYPE- protein

(ill) HYPOTHETICAL. YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE-

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...122

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 666 :

Arg Arg Ser Leu Tyr Tyr Val Phe He Lys Ser Tyr Ala He Leu Ala

1 5 10 15

Glu Ala Thr Ala Arg Phe Ala Gly Asp Tyr Ala Thr Glu Asn Leu Thr

20 25 30

Ser Arg He Ala Leu Pro Cys Ser Asp Tyr Val Gly Arg Val He Gly

35 40 45

Lys Asp Gly Lys Asn He Glu Ala Phe Lys Lys He Ser Gly Val Asp

50 55 60

He Glu Phe Ser Glu Asp Ser Ser Glu Leu Cys Leu Ser Ser Phe Asn 65 70 75 80

He Tyr Arg Arg Glu Val Ala Ser Glu Thr He Lys He Leu He Glu

85 90 95

Asp Gly Arg He Gin Pro Asn Arg He Glu Glu Val Tyr Pro Lys He

100 105 110

His Pro Gin His Gly Lys Arg He Ala Phe 115 120

(2) INFORMATION FOR SEQ ID NO: 667:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 250 ammo acids

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi ) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...250

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 667:

Lys Thr Ala Val Ser Ser Leu Thr Gly Leu Lys Arg Phe He Leu Lys 1 5 10 15 Phe Thr Arg Asn Met Glu Lys Glu Leu Leu Ser Glu Gly Glu Ser Val

20 25 30

Val Leu Glu Leu Glu Leu Gly Thr Met Glu Asp Glu Leu Lys He Leu

35 40 45

He Gly Lys Met Arg Tyr Arg Phe Ser Phe Gly Gin Asn Ala Leu Gin

50 55 60

His Ser Lys Glu He Ala Leu Leu Ser Gly Leu He Ala Glu Gin Leu 65 70 75 80

Gly Gly Asp Lys Lys Leu Ala Arg Arg Ala Gly He Leu His Asp He

85 90 95

Gly Lys Ala Leu Thr Gin Glu Leu Gly Arg Asp His Val Asn Leu Gly

100 105 110

Val Glu Val Cys Lys Arg His Lys Glu Asp Pro Val Val He Asn Ala

115 120 125

He Tyr Ala His His Gly His Glu Glu He Met Ser Val Glu Cys Ala

130 135 140

Ser Val Cys Ala Ala Asp Ala Leu Ser Ala Gly Arg Pro Gly Ala Arg 145 150 155 160

Arg Lys Ser Asp Glu Glu Tyr Ala Lys Arg Met Gin Ala Leu Glu Glu

165 170 175

He Ala Leu Glu Phe Asp Gly Val Glu Lys Ala Tyr Ala Met Glu Ser

180 185 190

Gly Arg Glu Leu Arg Val He Val Lys Ser Asn Gin Val Arg Asp Asn

195 200 205

Gin Val Pro He He Ala Arg Lys He Ala Lys Arg He Glu Glu Ser

210 215 220

Thr Gin Tyr Val Gly Glu Val Gly Val Gin Val Val Arg Glu Asn Arg 225 230 235 240

Phe Lys Thr Thr Ala Thr Leu Ser Asn Asp 245 250

(2) INFORMATION FOR SEQ ID NO: 668:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 804 ammo acids

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(m) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...804

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 668:

Ser Leu Trp Leu Lys Ser Lys Phe Phe Leu Leu Met Gly Val Gly Leu

1 5 10 15

Leu Ser His Ser Leu Asn Ala Leu Ser Leu Thr Leu Thr Gin Gly Lys

20 25 30

Glu Glu Gly Glu Asp Phe Ser Val Leu Thr Leu Arg Asn Asp Lys Ala 35 40 45 Phe Ser Cys Ser Tyr Ala Asn Glu Lys Pro Pro Ser Gly He Glu Ala

50 55 60

Ser Leu Ser He He His Ala Lys Arg Pro He Glu Cys Val He Asp 65 70 75 80

Ser He Pro Lys Glu Gly Phe Thr Pro Leu Glu Asn Ala Phe Phe Asn

85 90 95

He Thr Tyr Ser Met Arg Gin Gin Gin Phe He Leu His He Lys Pro

100 105 110

Lys Val Met Arg Arg Leu Thr Leu Phe Ser Phe Asp Arg Asp Tyr Lys

115 120 125

Lys Ala He Pro Leu Phe Val Glu Asn Asp Ala Lys Ala Lys Met Trp

130 135 140

Gin He He Gly Tyr Asp Gin Lys He Pro Phe Leu Ser Glu Lys Asp 145 150 155 160

Asn Ala Gin Lys Gly Leu Asn Phe Pro He He He Lys Asp Ala Gin

165 170 175

Thr Pro He He Gin Glu Leu Asp Val Asn Asn Lys Pro Leu Leu Thr

180 185 190

Thr Lys Gly Tyr Asp Leu Asn Ala Tyr Leu Glu Ala Lys Lys Gin Met

195 200 205

Asp Ser Gin Ala Tyr Phe Asp Ala Leu Arg Thr He Ser Arg Ala Phe

210 215 220

Lys Asn Tyr Pro Gin Thr He Phe Lys Lys Asp Leu Tyr Leu Leu Glu 225 230 235 240

He He Ala Leu Gly Lys Leu Gly He Lys Lys Ser Leu Leu He Asp

245 250 255

He Gly Thr Gin Trp He Lys Asn Tyr Pro Thr Asp Pro Asn He Pro

260 265 270

Glu Ala Leu Tyr Tyr Val Ala Lys Ala Leu Asp Glu Asn Asn Asn Tyr

275 280 285

Lys Gin Ala Val Arg Tyr Tyr Lys Arg He Leu Leu Glu Tyr Lys Asn

290 295 300

Ser Arg Tyr Ala Pro Leu Ala Gin Met Arg Leu Ala He Glu Ala Ala 305 310 315 320

Glu Gly Ser Asp Leu Ser Asn Ala Asn Met Leu Phe Lys Glu Ala Phe

325 330 335

Ser Asn Ala Lys Asp Lys Glu Ser Ala Ser Glu He Ala Leu Asn Trp

340 345 350

Ala Glu Ala Glu He Asn Tyr Gin Asn Phe Asn Asn Ala Lys Tyr Leu

355 360 365

He Asp Lys Val Val Gin Ser Asn Pro Asp Tyr Leu Ser Met His Ser

370 375 380

Glu Leu Ala Leu Glu Leu Leu Lys Leu Leu Lys Lys Asn Gin Met Asn 385 390 395 400

Glu Ser Ala He Glu He Ala His Leu Leu Leu Asn Gin Asp Asp Asp

405 410 415

Leu Lys Ala Lys Glu Gin Ala Leu Tyr Asp Leu Gly Ala Leu Tyr Ala

420 425 430

Arg He Lys Asp Phe Lys Asn Ala His Leu Tyr Asn Leu Gin Tyr Leu

435 440 445

Gin Asp His Ala Glu Leu Glu Arg Ala Ser Val Val Arg Ala Arg Asp

450 455 460

Glu Lys Ala Leu Phe Ser Met Glu Gly Asn Thr Gin Glu Lys He Ala 465 470 475 480

His Tyr Asp Lys He He Gin Asn Phe Pro Asn Ser Asn Glu Ala Gin

485 490 495

Lys Ala Leu Glu Leu Lys Ala Gin Leu Leu Phe Asp Asn Lys His Tyr 500 505 510

Ala Glu Val Leu Gly Met Gin Lys Asn Leu Pro Lys Asp Ser Pro Leu

515 520 525

He Gin Lys Thr Leu Asn He Leu Ala Lys Thr Pro Leu Glu Asp His

530 535 540

Arg Cys Lys Glu Ala Leu Lys Tyr Leu Ser Gin He Thr Ala Phe Ala 545 550 555 560

Phe Asn Pro Gin Glu Glu He Gin Ala Phe Asp Cys Leu Tyr Phe Ala

565 570 575

Ser Leu Lys Glu Lys Ala Gin He He Ala Leu Asn Ala Leu Lys Ala

580 585 590

Ala Lys Thr Pro Ser Glu Lys Leu Thr Trp Leu Tyr Arg Leu Gly Arg

595 600 605

Asn Tyr Tyr Arg Leu Gly Asp Phe Lys Asn Ser Thr Leu Ala Ser Lys

610 615 620

Asp Ala Leu He Leu Ala Gin Ser Leu Asn Lys Lys Glu Phe Tyr Asp 625 630 635 640

He Ala Phe Val Leu Phe Ser Asp Tyr Met Gin Asn Asn Glu Lys Gly

645 650 655

Leu Ala Leu Asn Leu Tyr Ala Phe Leu Glu Lys His Phe Lys Asp Asp

660 665 670

Lys Arg Met Ala Leu Val Tyr Phe Lys Leu Leu Glu Asn Glu Lys Asp

675 680 685

Pro Lys Ser Val Lys He Tyr Ala Thr Ser Leu Leu Lys Leu Gin Asp

690 695 700

Ala Tyr Lys Asp Tyr Ser Tyr Thr Pro Phe Gly Glu Phe Ala Leu He 705 710 715 720

Asp Ala Tyr Arg Thr Thr Lys Asp Tyr Ser Lys Ala Leu Glu Thr Leu

725 730 735

Asp Lys Leu Leu Asn Arg Arg Leu Ser Leu Glu Asp His Gin Lys Ala

740 745 750

Leu Tyr Leu Gin Ser Ser Leu Leu Asp Leu Thr Asn Gin Lys Ala Lys

755 760 765

Ser Lys Ala Ser Leu Glu Lys Cys Val Gin Leu Lys Gin Lys Asp Gin

770 775 780

Thr Asn Ala Trp Gin Asn Leu Cys Glu Gin Gly Leu Asn Leu Phe Lys 785 790 795 800

Asn Lys Glu Ser

(2) INFORMATION FOR SEQ ID NO: 669:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 382 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...382 ( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 669 :

Lys Hi s Pro Asn Arg Phe Phe Phe Lys Arg He Glu Arg Thr Ala Leu

1 5 10 15

Lys Pro Asn Thr Phe Leu Asn Ala Pro Met Gin Lys Pro Gin Asn Lys

20 25 30

Pro Ser Ser Ser Gin Gin Ser Pro Gin Asn Phe Ser Tyr Pro Glu Ser

35 40 45

Lys Leu Gly Ser Lys Asn Ser Lys Asn Ser Leu Leu Gin Pro Leu Val

50 55 60

Thr Pro Ser Lys Val Ser Pro Thr Asn Glu Val Lys Thr Pro Thr Asn 65 70 75 80

Asp Ala Asn Pro Pro Leu Lys His Ser Ser Gin Asp Gin Glu Asn Asn

85 90 95

Leu Phe Val Ala Pro Pro Thr Glu Lys Thr Leu Pro Asn Asn Thr Ser

100 105 110

Ser Ala Asp Ala Ser Glu Asn Asn Glu Ser Asn Glu Asn Arg Asp Asn

115 120 125

Val Glu Lys Gin Ala He Arg Asp Pro Asn He Lys Glu Phe Ala Cys

130 135 140

Gly Lys Trp Val Tyr Asp Asp Glu Asn Leu Gin Ala Tyr Arg Pro Ser 145 150 155 160

He Leu Lys Arg Val Asp Lys Asp Lys Glu He Thr Thr Asp He Thr

165 170 175

Pro Cys Asp Tyr Ser Thr Ala Glu Asn Lys Ser Gly Lys He He Thr

180 185 190

Pro Tyr Thr Lys He Ser Val His Lys Thr Glu Pro Leu Glu Asp Pro

195 200 205

Gin Thr Phe Glu Ala Lys Asn Asn Phe Ala He Leu Gin Ala Arg Ser

210 215 220

Ser Thr Glu Lys Cys Lys Arg Ala Arg Ala Arg Lys Asp Gly Thr Thr 225 230 235 240

Arg Gin Cys Tyr Leu He Glu Glu Pro Leu Lys Gin Ala Trp Glu Ser

245 250 255

Glu Tyr Glu He Thr Thr Gin Leu Val Lys Ala He Tyr Glu Arg Pro

260 265 270

Lys Gin Asp Asp Gin Val Glu Pro Thr Phe Tyr Glu Thr Ser Glu Leu

275 280 285

Ala Tyr Ser Ser Thr Arg Lys Ser Glu He Thr Arg Asn Glu Leu Asn

290 295 300

Leu Asn Glu Lys Phe Met Glu Phe Val Glu Val Tyr Glu Gly His Tyr 305 310 315 320

Leu Asn Asp He He Lys Glu Ser Ser Glu Tyr Lys Glu Trp Val Lys

325 330 335

Asn His Val Arg Phe Lys Glu Arg Val Cys Met Ala Leu Lys He Lys

340 345 350

Lys Gin Pro Arg Ala Lys Ser Thr Pro Leu Ser He Glu Asn Ser Arg

355 360 365

Val Val Cys Val Lys Lys Gly Asn Tyr Leu Phe Asn Glu Val 370 375 380

(2) INFORMATION FOR SEQ ID NO: 670:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 105 amino acids

(B) TYPE: amino acid (D) TOPOLOGY linear

(11) MOLECULE TYPE- protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM. Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...105

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 670 .

Thr Lys Lys Leu Asn Asn Thr Leu Phe Asn Lys Gly Leu He He Phe

1 5 10 15

Lys Met Phe Lys Lys He He Phe Leu Cys Val Phe Leu He Gly Gly

20 25 30

Phe Val He Pro Pro Leu Glu Ala Met Pro He Leu Arg Asn Lys Thr

35 40 45

Pro Lys Lys Asn Tyr Gin Glu Ala His Glu Lys Leu Tyr Arg Ser He

50 55 60

He Asn Arg Gin Lys Leu Thr Arg Lys Lys Ser Gly Trp Tyr Phe Leu 65 70 75 80

Gly Gly Val Gly Ala Val Glu Ala He Lys Asp Tyr Gin Gly Lys Glu

85 90 95

Met Lys Asp Trp Met Pro Arg Ser He 100 105

(2) INFORMATION FOR SEQ ID NO: 671:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 69 ammo acids

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...69

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 671:

Ser Lys Thr Ser Tyr Cys Asn Ser Tyr Lys Arg Lys Leu Leu Pro Tyr

1 5 10 15

His Phe Leu Leu Phe Pro Leu Trp Ala Cys Phe His Asn Val Ser Arg

20 25 30

Pro Phe Ser Leu Ser His Leu Phe Leu Val Lys Arg Pro Tyr Ser Arg

35 40 45

Leu Tyr Leu His Asn Gin Ser Asn His Lys Met Arg His His Ser He 50 55 60

Leu Phe Val Ser Phe 65

(2) INFORMATION FOR SEQ ID NO: 672:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 458 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...458

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 672:

Gin Asp Lys Gly Leu Leu Leu Ser Val Ala Leu Pro Asn Ser Asn Asn

1 5 10 15

Ala Ser Gin Asn Asn He Leu Ser Leu Ser Val Leu His Asn Gin He

20 25 30

Lys Met Ser Tyr Gly Asn Lys Val Met Asp Phe Thr Pro Pro Thr Leu

35 40 45

Gin Asp Tyr He Val Gly He Gin Gly Gin Ser Ala Leu Asn Gin He

50 55 60

Glu Ala Val Gly Gly Asn Asn Ala He Lys Trp Leu Ser Thr Leu Met 65 70 75 80

Met Glu Thr Lys Glu Asn Pro Leu Phe Ala Pro He Tyr Leu Glu Asn

85 90 95

His Ser Leu Asn Glu He Leu Gly Val Thr Lys Asp Leu Gin Asn Thr

100 105 110

Ala Ser Leu He Ser Asn Pro Asn Phe Arg Asn Asn Ala Thr Ser Leu

115 120 125

Leu Glu Met Ala Ser Tyr Thr Gin Gin Thr Ser Arg Leu Thr Lys Leu

130 135 140

Ser Asp Phe Arg Ala Arg Glu Gly Glu Ser Asn Phe Ser Glu Arg Leu 145 150 155 160

Leu Glu Leu Lys Asn Lys Arg Phe Ser Asp Pro Asn Pro Ser Glu Val

165 170 175

Phe Val Lys Tyr Ser Gin Leu Ser Lys His Pro Asn Asn Leu Trp He

180 185 190

Gin Gly Val Gly Gly Ala Ser Phe He Ser Gly Gly Asn Gly Thr Leu

195 200 205

Tyr Gly Leu Asn Val Gly Tyr Asp Arg Leu Val Lys Ser Val He Leu

210 215 220

Gly Gly Tyr Val Ala Tyr Gly Tyr Ser Gly Phe Asn Gly Asn He Met 225 230 235 240

His Ser Leu Ala Asn Asn Val Asp Val Gly Met Tyr Ala Arg Ala Phe

245 250 255

Leu Lys Arg Asn Glu Phe Thr Leu Ser Ala Asn Glu Thr Tyr Gly Gly 260 265 270

Asn Ala Ser His He Asn Ser Ser Asn Ser Leu Leu Ser Val Leu Asn

275 280 285

Gin Arg Tyr Asn Tyr Asn Thr Trp Thr Thr Ser Val Asn Gly Asn Tyr

290 295 300

Gly Tyr Asp Phe Met Phe Lys Gin Lys Ser Val Val Leu Lys Pro Gin 305 310 315 320

Val Gly Leu Ser Tyr His Phe He Gly Leu Ser Gly Met Lys Gly Lys

325 330 335

Met Gin Asn Pro Ala Tyr Gin Gin Phe Val Met His Ser Asn Pro Ser

340 345 350

Asn Glu Ser Val Leu Thr Leu Asn Met Gly Leu Glu Ser Arg Lys Tyr

355 360 365

Phe Gly Lys Asn Ser Tyr Tyr Phe Val Thr Ala Arg Leu Gly Arg Asp

370 375 380

Leu Leu He Lys Ala Lys Gly Asp Asn Val Val Arg Phe Val Gly Glu 385 390 395 400

Asn Thr Leu Leu Tyr Arg Lys Gly Glu He Phe Asn Thr Phe Ala Ser

405 410 415

Val He Thr Gly Gly Glu Met His Leu Trp Arg Leu Met Tyr Val Asn

420 425 430

Ala Gly Val Gly Leu Lys Met Gly Leu Gin Tyr Gin Asp Leu Asn He

435 440 445

Thr Gly Asn Val Gly Met Arg Val Ala Phe 450 455

(2) INFORMATION FOR SEQ ID NO: 673:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 186 ammo acids

(D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(ill) HYPOTHETICAL : YES

(vi ) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...186

( Xl ) SEQUENCE DESCRIPTION : SEQ ID NO : 673 :

Pro Phe Glu Ala Leu Asn Phe Tyr Ser Lys Lys Ala Leu Asn Glu He

1 5 10 15

Phe Ala Asn Ala Arg Lys He Cys Gly Asn Lys Pro Leu Gly Ala Asn

20 25 30

He Leu Tyr Ala He Asn Asp Tyr Gly Arg Val Leu Arg Asp Ser Cys

35 40 45

Glu Ala Gly Ala Asn He He He Thr Gly Ala Gly Leu Pro Thr Asn

50 55 60

Met Pro Glu Phe Ala Lys Asp Phe Ser Asp Val Ala Leu He Pro He 65 70 75 80

He Ser Ser Ala Lys Ala Leu Lys He Leu Cys Lys Arg Trp Ser Asp 85 90 95

Arg Tyr Lys Arg He Pro Asp Ala Phe He Val Glu Gly Pro Leu Ser

100 105 110

Gly Gly His Gin Gly Phe Lys Tyr Glu Asp Cys Phe Lys Glu Glu Phe

115 120 125

Gin Leu Glu Asn Leu Val Pro Lys Val Val Glu Ala Ser Lys Glu Trp

130 135 140

Gly Asn He Pro He He Ala Ala Gly Gly He Trp Asp Arg Lys Asp 145 150 155 160

He Asp Thr Met Leu Ser Leu Gly Ala Ser Gly Val Gin Met Ala He

165 170 175

Ser Phe Phe Arg His Glu Arg Met Arg Arg 180 185

(2) INFORMATION FOR SEQ ID NO: 674:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 88 ammo acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(m) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...88

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 674 :

Ala He Arg Leu Arg Leu Ser He Arg Gly Leu He Lys Arg He Glu

1 5 10 15

Glu Gly Asn Ala Pro Lys He Ala Cys Val Ser Asn Cys Val Thr Pro

20 25 30

Cys Asn Arg Gly Glu Glu Thr Lys Lys Val Gly Tyr Cys He Ala Asp

35 40 45

Gly Leu Gly Arg Ser Tyr Leu Gly Asn Arg Glu Glu Gly Leu Tyr Phe

50 55 60

Thr Gly Ala Asn Gly Tyr Arg Val Asp Lys He He Ser Val His Glu 65 70 75 80

Leu He Lys Glu Leu Thr Glu Gly 85

(2) INFORMATION FOR SEQ ID NO: 675:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 284 ammo acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...284

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 675 :

Asn Phe Asn Gin Arg Ala Phe Leu Lys Arg Ala Leu Trp Leu He Leu

1 5 10 15

Gly Leu Phe Tyr Ala Leu Asn Ala Glu Ser Phe Lys Asp Val Leu Thr

20 25 30

Lys Gly Asp Tyr Thr Phe Phe Asn Lys Lys Val Val Ser Pro He Lys

35 40 45

Arg Tyr Ala Asp Arg Ser Ala Phe Tyr Leu Gly Leu Gly Tyr Gin Leu

50 55 60

Gly Ser He Gin His Asn Ser Ser Asn Leu Asn Leu Ser Gin Arg Phe 65 70 75 80

Asn Lys Ser Gin He He Phe Ser Asp Ser Leu Ser Pro Val Phe Lys

85 90 95

Asn Ser Tyr Val Ser Asn Gly Leu Gly Val Gin Val Gly Tyr Lys Trp

100 105 110

Val Gly Lys His Glu Glu Thr Lys Trp Phe Gly Phe Arg Trp Gly Leu

115 120 125

Phe Tyr Asp Leu Ser Ala Ser Leu Tyr Gly Ser Gin Glu Ser Gin Ser

130 135 140

He He He Ser Thr Tyr Gly Thr Tyr Met Asp Leu Leu Leu Asn Ala 145 150 155 160

Tyr Asn Gly Asp Lys Phe Phe Ala Gly Phe Asn Leu Gly He Ala Phe

165 170 175

Ala Gly Val Tyr Asp Arg Leu Ser Asp Ala Leu Leu Tyr Gin Thr Leu

180 185 190

Leu Gin Asn Thr Phe Gly Gly Lys Val Asn Leu Asn Gly Phe Gin Phe

195 200 205

Leu Val Asp Leu Gly Val Arg Leu Gly Asn Glu His Asn Gin Phe Gly

210 215 220

Phe Gly He Lys He Pro Thr Tyr Tyr Phe Asn His Tyr Tyr Ser Met 225 230 235 240

Asn Asn He Ser Asn Asn Ser Glu Asn Val Leu Lys Val Leu Arg Phe

245 250 255

Leu Glu Tyr Gly He Asn Ser Leu Leu Tyr Gin Val Asp Phe Arg Arg

260 265 270

Asn Tyr Ser Val Tyr Phe Asn Tyr Thr Tyr Ser Phe 275 280

(2) INFORMATION FOR SEQ ID NO: 676:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 66 ammo acids

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(m) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...66

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 676 :

Lys Met His Thr Ser Phe Phe Gin He Pro Leu Asn Phe Gly Val Arg

1 5 10 15

Val Asn Val Asp Arg His Asn Gly Phe Glu Met Gly Leu Lys He Pro

20 25 30

Leu Ala Val Asn Ser Phe Tyr Glu Thr His Gly Lys Gly Leu Asn Ala

35 40 45

Ser Leu Phe Phe Lys Arg Leu Val Met Phe Asn Val Ser Tyr Val Tyr

50 55 60

Ser Phe 65

(2) INFORMATION FOR SEQ ID NO: 677:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 138 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...138

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 677 :

He Lys Arg He He Lys Ser Asn Ala Ser Leu Asn Gin Leu Asn Thr

1 5 10 15

Thr Arg Tyr Asn Thr Pro Ser His Leu Phe Phe Lys Lys Gly Val Gly

20 25 30

Met Ala Thr He Gin Pro Phe Asn His Ser Thr He Gin Pro Phe Asn

35 40 45

His Ser Thr He Gin Pro Phe Asn His Ser He He Gin Ser Phe Asn

50 55 60

His Ser Thr He Gin Ala Thr Leu Pro Tyr Phe Tyr Asn Tyr Leu Ser 65 70 75 80

Phe Tyr Lys Asn Leu Phe Lys Asn Pro Leu Phe Phe He He Pro Pro

85 90 95

Phe He Asn Pro Phe He Asn Pro Phe He Asn Pro Phe He Asn Pro

100 105 110

Phe He Asn Pro Phe He Asn Pro Phe He Asn Pro Phe He Asn Pro 115 120 125 Phe He Asn Pro Phe He Asn Pro Phe He 130 135

(2) INFORMATION FOR SEQ ID NO: 678:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 193 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...193

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 678:

Arg Tyr His His Phe Ser Gly Leu Ser Ser Cys Gly Phe Ser Ala Gin

1 5 10 15

Cys Gly Cys Gly His Val Ala Ser His Ser Leu Trp His Gin Leu Trp

20 25 30

Pro Trp Pro Asn Leu Gly Pro Glu His Leu Glu Asn Gly Gly Val Arg

35 40 45

Ser Phe Asp Asn Thr Pro Asn Tyr Ser Tyr Asn Thr Gly Ser Gly Thr

50 55 60

Thr Thr Thr Thr Cys Asn Gly Ala Ser Asn Val Gly Pro Asn Gly He 65 70 75 80

Leu Ser Ser Ser Glu Tyr Gin Val Leu Asn Thr Ala Tyr Gin Thr He

85 90 95

Gin Thr Ala Leu Asn Gin Asn Gin Gly Gly Gly Met Pro Ala Leu Asn

100 105 110

Ser Ser Lys Asn Met Val Val Asn He Asn Gin Thr Phe Thr Lys Asn

115 120 125

Pro Thr Thr Glu Tyr Thr Tyr Pro Asp Gly Asn Gly Asn Tyr Tyr Ser

130 135 140

Gly Gly Ser Ser He Pro He Gin Leu Lys He Ser Ser Val Asn Asp 145 150 155 160

Ala Glu Asn Leu Leu Gin Gin Ala Ala Thr He He Asn Val Leu Thr

165 170 175

Thr Gin Asn Pro His Val Asn Gly Gly Gly Gly Val Met Gly Val Trp

180 185 190

Arg

(2) INFORMATION FOR SEQ ID NO: 679:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 418 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...418

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 679:

Met Val Val Val Gly Ser Trp Gly Phe Gly Gly Lys Thr Gly Asn Val

1 5 10 15

Met Asp He Phe Gly Asp Ser Phe Asn Ala He Asn Glu Met He Lys

20 25 30

Asn Ala Gin Ala Val Leu Glu Lys Thr Gin Gin Leu Asn Ala Asn Glu

35 40 45

Asn Thr Gin He Thr Gin Pro Asp Asn Phe Asn Pro Tyr Thr Ser Lys

50 55 60

Asp Thr Gin Phe Ala Gin Glu Met Leu Asn Arg Ala Asn Ala Gin Ala 65 70 75 80

Glu He Leu Ser Leu Ala Gin Gin Val Ala Asp Asn Phe His Ser He

85 90 95

Gin Gly Pro He Gin Gin Asp Leu Glu Glu Cys Thr Ala Gly Ser Ala

100 105 110

Gly Val He Asn Asp Asn Thr Tyr Gly Ser Gly Cys Ala Phe Val Lys

115 120 125

Glu Thr Leu Asn Ser Leu Glu Gin His Thr Ala Tyr Tyr Gly Asn Gin

130 135 140

Val Asn Gin Asp Arg Ala Leu Ser Gin Thr He Leu Asn Phe Lys Glu 145 150 155 160

Ala Leu Ser Thr Leu Gly Asn Asp Ser Lys Ala He Asn Ser Gly He

165 170 175

Ser Asn Leu Pro Asn Ala Lys Ser Leu Gin Asn Met Thr His Ala Thr

180 185 190

Gin Asn Pro Asn Ser Pro Glu Gly Leu Leu Thr Tyr Ser Leu Asp Thr

195 200 205

Ser Lys Tyr Asn Gin Leu Gin Thr Val Ala Gin Glu Leu Gly Lys Asn

210 215 220

Pro Phe Arg Arg He Gly Val He Asn Tyr Gin Asn Asn Asn Gly Ala 225 230 235 240

Met Asn Gly He Gly Val Gin Ala Gly Tyr Lys Gin Phe Phe Gly Lys

245 250 255

Lys Arg Asn Trp Gly Leu Arg Tyr Tyr Gly Phe Phe Asp Tyr Asn His

260 265 270

Ala Tyr He Lys Ser Asn Phe Phe Asn Ser Ala Ser Asp Val Trp Thr

275 280 285

Tyr Gly Val Gly Met Asp Ala Leu Tyr Asn Phe He Asn Asp Lys Asn

290 295 300

Thr Asn Phe Leu Gly Lys Asn Asn Lys Leu Ser Val Gly Leu Phe Gly 305 310 315 320

Gly Phe Ala Leu Ala Gly Thr Ser Trp Leu Asn Ser Gin Gin Val Asn

325 330 335

Leu Thr Met Met Asn Gly He Tyr Asn Ala Asn Val Ser Ala Ser Asn 340 345 350 Phe Gin Phe Leu Phe Asp Leu Gly Leu Arg Met Asn Leu Ala Arg Pro

355 360 365

Lys Lys Lys Asp Ser Asp His Ala Ala Gin His Gly Met Glu Leu Gly

370 375 380

Val Lys He Pro Thr He Asn Thr Asp Tyr Tyr Ser Phe Met Gly Ala 385 390 395 400

Glu Leu Lys Tyr Arg Arg Leu Tyr Ser Val Tyr Leu Asn Tyr Val Phe

405 410 415

Ala Tyr

(2) INFORMATION FOR SEQ ID NO: 680:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 163 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...163

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 680:

Ala Leu Ser Arg Cys Leu Ser Asp Arg Phe Asn Gin Tyr Pro Ala Leu

1 5 10 15

Gin Lys Thr Glu His His Phe Val Asp Phe Leu Asn Gin Asp Lys His

20 25 30

Tyr Ala He He Gin Arg Ala Asp Lys Ser He Ser Ser Asn Glu Ala

35 40 45

Leu Ala Arg Ser Leu He Gly Ala Tyr Val Leu Asn Arg Glu Ser He

50 55 60

Asn Arg He Asp Asp Lys Ser Arg Tyr Glu Leu Val Arg Leu Gin Ser 65 70 75 80

Ser Ser Lys Val Trp Gin Arg Phe Glu Asp Leu He Lys Ala Gin Asn

85 90 95

Ser He Tyr Val Gin Ser His Leu Glu Arg Glu Val His He Val Asn

100 105 110

He Ala He Tyr Gin Gin Asp Asn Asn Pro He Ala Ser Val Ser He

115 120 125

Ala Ala Lys Leu Leu Asn Glu Asn Lys Leu Val Tyr Glu Lys Arg Tyr

130 135 140

Lys He Val Leu Ser Tyr Leu Phe Asp Thr Pro Asp Phe Asp Tyr Ala 145 150 155 160

Ser Met Pro

[ 2 ) INFORMATION FOR SEQ ID NO: 681: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 194 ammo acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(m) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...194

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 681:

Ser Phe Lys Lys Asn Glu Arg Leu Leu Leu Leu Val Ser Arg Phe Leu

1 5 10 15

Asn Ala He Asp Pro Phe Asn Leu Gly Val Leu Leu Ser Arg Phe Gin

20 25 30

He Lys Asn Gly Cys He Tyr Gly Val Cys Ser Tyr Lys Val Ser Lys

35 40 45

Phe Thr Pro Gly Tyr Glu Glu Ser Lys Ala Arg Val Leu Asn Ala Leu

50 55 60

Asn He Leu Ser Lys His Gin He Trp Gin Ser Asn Gin Glu Ser Val 65 70 75 80

Thr Lys Val Lys Gly Thr Phe Val Phe He Leu Glu Asn Asp Leu His

85 90 95

Leu Asp Glu Asn Ser Phe Tyr Lys Lys Leu Leu Asn Leu He He Asp

100 105 110

Asn Asp Phe Phe Asn Arg Ser His Leu Val Thr Pro Ser Asn Gly Thr

115 120 125

Asn Ser His Pro Glu Leu His Arg Ser He Thr Pro Arg Glu Ala Ala

130 135 140

Arg He Gin Ser Phe Ser Asp Asp Tyr He Phe Tyr Gly Asn Lys Thr 145 150 155 160

Ser Val Cys Lys Gin He Gly Asn Ala Val Pro Pro Leu Leu Ala Leu

165 170 175

Ala Leu Gly Lys Ala He Leu Lys Ser Ala Arg Asn Asp Thr Asn Pro

180 185 190

Ser Arg

(2) INFORMATION FOR SEQ ID NO: 682:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 165 ammo acids

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori (ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...165

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 682 :

Met Gin Asp Asn Leu Val Ser Val He Glu Lys Gin Thr Asn Lys Lys

1 5 10 15

Val Arg Met Leu Glu He Lys Pro Leu Lys Ser Ser Gin Asp Leu Lys

20 25 30

Met Val Val He Glu Asp Pro Asp Thr Lys Tyr Asn He Pro Leu Val

35 40 45

Val Ser Lys Asp Gly Asn Ser Val He Gly Leu Ser Asn He Phe Phe

50 55 60

Ser Asn Lys Ser Asp Asp Val Lys Leu Val Ala Glu Thr Asn Gin Lys 65 70 75 80

He Gin Ala Leu Asn Ala Thr Gin Gin Asn Ser Ala Lys Leu Asn Ala

85 90 95

He Phe Asn Glu He Pro Ala Asp Tyr Ala He Glu Leu Pro Ser Thr

100 105 110

Asn Ala Glu Asn Lys Asp Lys He Leu Tyr He Val Ser Asp Pro Met

115 120 125

Cys Pro His Cys Gin Lys Glu Leu Thr Lys Leu Arg Asp His Leu Lys

130 135 140

Glu Asn Thr Val Arg Met Val Val Val Gly Trp Leu Glu Ala He Arg 145 150 155 160

Leu Lys Lys Arg Leu 165

(2) INFORMATION FOR SEQ ID NO: 683:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 115 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...115

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 683 :

Thr Gly Ala He Met Leu Ser Ser Asn Asp Leu Phe Met Val Val Leu

1 5 10 15

Gly Ala He Leu Leu Val Leu Val Cys Leu Val Gly Tyr Leu Tyr Leu

20 25 30

Lys Glu Lys Glu Phe Tyr His Lys Met Arg Arg Leu Glu Lys Thr Leu

35 40 45

Asp Glu Ser Tyr Gin Glu Asn Tyr Leu Tyr Ser Lys Arg Leu Arg Glu 50 55 60

Leu Glu Gly Arg Leu Glu Gly Leu Ser Leu Glu Lys Ser Ala Lys Glu 65 70 75 80

Asp Ser Ser Leu Lys Thr Thr Leu Ser His Leu Tyr Asn Gin Leu Gin

85 90 95

Glu He Gin Lys Ser Met Asp Lys Glu Arg Asp Tyr Leu Glu Glu Lys

100 105 110

He He Thr 115

(2) INFORMATION FOR SEQ ID NO: 684:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 324 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...324

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 684:

Glu Arg Lys Lys Met Asn Thr Asn Leu Lys Lys Ala Leu Phe Leu Thr

1 5 10 15

Thr Leu Gly Tyr Leu Gin Ala Asn Glu Gly Phe Leu Ala He Met Pro

20 25 30

Asp Glu Asn Lys Gin Glu Asp He Ser Gin Glu Gin Lys Leu Glu His

35 40 45

Lys Met Glu Gin Lys He Ala Pro Gin Asn Thr Leu Lys Lys Gin Gin

50 55 60

Ser Ala Pro Leu Gin Ser Ala Glu Leu Leu Gin Ser Gin Val Lys Arg 65 70 75 80

Glu Val Lys Glu Gin Lys Lys Ser Gin Lys His Leu Val Ala Met Gin

85 90 95

Thr Lys Asn Gly Phe Phe Leu Gly Ser Glu He Ala He Thr Gly Thr

100 105 110

Ser Leu Lys Gin Ser Leu Ser Leu He Ser Asn Ala Thr Asp Asp Leu

115 120 125

Leu Thr Tyr Ser Lys Thr Ser Lys Asn Ala Asn Phe Asn Met Gly Leu

130 135 140

Leu He Gly Tyr Gin His Tyr Phe Gly Ala Ser Lys Arg His Gly He 145 150 155 160

Lys He Ser Ser His Leu Tyr Gly Gly Thr Pro Ser Asp Val Ser Thr

165 170 175

Asp He Lys He Tyr Lys Ser Lys Val Ser Thr Asn Tyr Thr Pro Leu

180 185 190

Asn Phe Gly He Asp Val Lys Tyr Leu Phe Asp Phe Leu Asn Val He

195 200 205

Lys Lys Asn Arg His Thr Leu Gly Leu Ser Val Gly Phe Gly Trp Arg 210 215 220

Met Gin Tyr Tyr Phe Ala Lys He Asp Pro He Lys Thr Ser His Ser 225 230 235 240

Glu Phe He Thr Asn Lys Pro Lys Asp He Phe Asn His Gly Phe Tyr

245 250 255

Pro Thr He Gly Leu His Tyr Tyr Leu Asn His His Gin Phe Glu Val

260 265 270

Asn Tyr Arg Phe Gly Gly Ala He Asn Tyr Gin Ser Val Val Pro Ser

275 280 285

Lys He Val Val Gin Asn Gly Asn Phe Lys Gly Glu Val Leu Phe Ser

290 295 300

Asn Phe Leu Thr Lys Ala Thr Asn Ser Ser Tyr He Ala Phe Asn Tyr 305 310 315 320

Ala Tyr Leu Phe

(2) INFORMATION FOR SEQ ID NO: 685:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 137 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...137

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 685 :

Ala Asn Glu Lys Met Glu Leu He Lys Lys Leu Glu Lys Glu Ser Glu

1 5 10 15

Val Leu Lys Lys Asp Leu Gin Gin His Ser Asn Glu Leu Phe Lys Met

20 25 30

Leu He He Asp Asn Glu Asp Leu Phe Lys Glu Gin Phe Glu He Met

35 40 45

Phe Lys Ala Trp Val Glu He Val Lys Met Met Phe Glu Leu Thr Lys

50 55 60

Lys Thr Lys Phe Asp Gly Glu Met He Gly Tyr Thr Glu Glu Leu Leu 65 70 75 80

Thr Phe Leu Val Arg Asp Phe Phe Asn Gly He Phe Lys Ser Lys Val

85 90 95

He Pro Lys Met Pro He Phe Cys Gly Asp Val Lys Cys Glu Asp Phe

100 105 110

Asn Ala Leu Arg Ser Leu Val Tyr Leu Ser Val Leu Glu Leu Glu Glu

115 120 125

Thr He Asn Pro Asn Lys He Pro Phe 130 135

(2) INFORMATION FOR SEQ ID NO: 686: ( ) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 227 ammo acids

(B) TYPE- ammo acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(m) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

( ix ) FEATURE :

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...227

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 686 :

Asn Lys Glu Asn Asn He Thr He Cys Val Ala Asn Glu Lys Gly Gly

1 5 10 15

Ser Gly Lys Ser Thr Leu Cys Leu Asn Leu Ala Val Gin Leu Leu Lys

20 25 30

Asp Asn Lys Glu Val Val Val Leu Asp Thr Asp Ser Gin Lys Ser Met

35 40 45

Glu Thr Phe Ala Thr He Arg Ala Glu Lys Glu Arg Pro Thr Phe Ser

50 55 60

Leu Phe Asn Arg Ser Ser Gly Phe Ser Asp Thr Leu Lys Gin Met Val 65 70 75 80

Ser Lys Tyr Glu Asn He Leu He Asp Thr Lys Gly Glu Tyr Ser Lys

85 90 95

Glu Thr Gin Lys Ala Met Leu Leu Ser Asn He Val Leu Val Pro Thr

100 105 110

Thr Pro Ser Gin Leu Asp Thr Glu Val Leu Ala Asn Met Leu Glu Arg

115 120 125

He Glu Gin Leu Gin Glu Leu Asn Glu Asn Leu Arg Ala Leu He Val

130 135 140

He Asn Arg Met Pro Thr He Pro Thr Leu Lys Glu Arg Gin Ala Leu 145 150 155 160

He Glu Phe He Lys Glu Asn Asn Pro Ser Asp Arg He Thr Leu Leu

165 170 175

Glu Ser Ser Leu Ser Glu Arg He Val Tyr Lys Arg Ser Val Ser Glu

180 185 190

Gly Leu Gly Val He Glu Tyr Ser Asp Lys Lys Ala He Asn Glu Trp

195 200 205

Val Asn Phe Tyr Asn Glu Leu Lys Ser His Leu Glu Lys Glu Lys He

210 215 220 225

(2) INFORMATION FOR SEQ ID NO: 687:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 105 ammo acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...105

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 687 :

Arg Ser Thr Thr Leu He Tyr Phe Asn Phe Lys Glu Pro Met Met Ser

1 5 10 15

Asp Glu He Thr Gin Glu Asn Glu Leu Glu He Asn Ser Asn Asn Gin

20 25 30

Asn Gin Glu Pro Lys Glu Val Glu Lys Met Pro Leu Asn Asn He Gin

35 40 45

Lys Ala Lys Lys Leu Lys Asn His Ala Asn Leu He Val Arg Arg Thr

50 55 60

Asp Glu Leu Asp Lys Val He Asn Lys Arg Glu Ser Leu Gin Arg Glu 65 70 75 80

Phe Lys Arg Arg He Lys His Leu Asp Asn Lys He Glu Thr Leu Ser

85 90 95

Asn Asn He Glu Glu Leu Lys Arg Lys 100 105

(2) INFORMATION FOR SEQ ID NO: 688:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 173 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...173

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 688 :

Ser Met Lys Lys Tyr Gin Asn Lys Arg Lys Leu Gly Lys Arg He Asn

1 5 10 15

Cys Phe He Ser Asn Glu Cys Lys Asp He Leu Glu Asn Tyr Leu Lys

20 25 30

Val Lys Lys He Ser Val Thr Glu Cys He Glu Ser Leu Leu Leu Ala

35 40 45

Leu Asp Pro Ser Lys Glu Thr Leu Arg Ala Arg Asp Phe Tyr Glu Ser

50 55 60

Leu Phe Lys Val He Ser Leu Asn Gin His Val Tyr Lys Glu Leu Met 65 70 75 80 Ala Asn Gly Asn Asn He Asn Gin He Ala Lys Asn Thr Asn He Ala

85 90 95

He Lys Tyr Asn Lys Pro Phe Tyr Leu Gin Asn Leu Ala Phe Leu Glu

100 105 110

Glu He Phe Lys Val Met Asp Thr Leu Asn Lys Asn Val Glu Glu Cys

115 120 125

Lys Lys He Ser Leu Glu Leu Leu Leu Gin He Tyr Lys Glu Gin Lys

130 135 140

Ser Gin Thr Glu Phe Asn Ala He Ser Lys He Leu Asn Ala Leu Asn 145 150 155 160

Glu Lys Gin Ser Thr Thr Glu Pro Lys Lys Asp Asn Ala 165 170

(2) INFORMATION FOR SEQ ID NO: 689:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 109 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...109

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 689 :

Lys Ser Pro Tyr Arg His Ser He Ser Ser Gin Val Ser Val Glu Asn

1 5 10 15

Asp Glu Glu He He Glu Val Glu Lys Gly Glu Asn Gin Gly Ala Phe

20 25 30

Ser Tyr Phe Leu Gly Gly Pro Thr Cys Leu Ala Gly Asp Phe Met Gly

35 40 45

Ser Phe Ser Phe Glu Thr Pro Leu Lys Arg Gly Asp Lys He Val Phe

50 55 60

Gin Asp Met Leu His Tyr Thr He Val Lys Asn Asn Ser Phe Asn Gly 65 70 75 80

Val Pro Leu Pro Ser Leu Ala Lys He Asp Ser Gin Gly Phe Lys He

85 90 95

Leu Lys Ser Phe Ser Tyr Glu Asp Tyr Lys Asn Arg Asn 100 105

(2) INFORMATION FOR SEQ ID NO: 690:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 133 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein (m) HYPOTHETICAL : YES

(vi) ORIGINAL SOURCE

(A) ORGANISM Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...133

(Xl) SEQUENCE DESCRIPTION: SEQ ID NO: 690:

Ala Leu Glu Lys Asn Gly Thr Ala Thr Ala Asn Ser Thr Ser Ser Thr

1 5 10 15

Ser Gly Ala Thr Gly Ser Asp Gly Gin Thr Tyr Ser Gin Gin Ala He

20 25 30

Gin Tyr Leu Gin Gly Gin Gin Asn He Leu Asn Asn Ala Ala Asn Leu

35 40 45

Leu Lys Gin Asp Glu Leu Leu Leu Glu Ala Phe Asn Ser Ala Val Ala

50 55 60

Ala Asn He Gly Asn Lys Glu Phe Asn Ser Ala Ala Phe Thr Gly Leu 65 70 75 80

Val Gin Gly He He Asp Gin Ser Gin Leu Val Tyr Asn Glu Leu Thr

85 90 95

Lys Asn Thr He Ser Gly Ser Ala Val Asn Asn Ala Gly He Asn Ser

100 105 110

Asn Gin Ala Asn Ala Cys Lys Gly Val Leu Val Ser Ser Leu Thr Leu

115 120 125

Phe Thr Thr Cys Lys 130

(2) INFORMATION FOR SEQ ID NO: 691:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 84 ammo acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(Vl) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...84

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 691 :

Leu He Lys Glu Ala Met He Pro Val Phe Gly Ser Glu Thr Gly He

1 5 10 15

Tyr Asn His Lys Glu Gin Asn Phe Lys Gly Lys Gly Arg Phe He Leu

20 25 30

Thr Ser Lys Asp Ser Lys Val Glu Gly Leu Asp He Ser Tyr Ser His

35 40 45

Ala Leu Ala He He Glu Ala Gin Ser He Gin Ala Asn Leu Phe Leu 50 55 60

Asp Glu He Lys Gin Ser Gin Lys Glu Lys Lys Lys Phe Pro Thr Phe 65 70 75 80

Lys Gly Gly Phe

(2) INFORMATION FOR SEQ ID NO: 692.

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 161 ammo acids

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi ) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...161

( Xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 692 :

Pro Phe Leu Lys Lys Asn Lys Phe Leu Gin He Cys Gin Tyr Phe Ser

1 5 10 15

Ala His Phe Lys Gin Val Leu Lys Asn Glu Lys Pro Leu Val Tyr Tyr

20 25 30

Gly Val Leu Lys Ala Lys Ala Pro Asn Trp Ala Leu Trp Val Tyr Glu

35 40 45

Lys Pro Leu Lys Lys Glu He Tyr Met Asn Asp Lys Glu Val Val Val

50 55 60

Tyr Glu Pro Asn Leu Phe Gin Ala Thr He Thr Pro Leu Lys Asp Lys 65 70 75 80

Thr Asp Phe Phe Thr He Leu Lys Gin Leu Lys Lys Gin Thr Asp Gly

85 90 95

Ser Phe Lys Thr Thr He Asn Lys Thr Thr Tyr Arg Leu Val Phe Lys

100 105 110

Asp Gly Lys Pro Phe Ser Leu Glu Phe Lys Asp Asp Met Asn Asn Leu

115 120 125

Val Thr He Thr Phe Ser Gin Ala Glu He Asn Pro Lys He Pro Asn

130 135 140

Glu He Phe Val Phe Asn Pro Lys Asp Glu Asn He Asp He Val Arg 145 150 155 160

Gin

(2) INFORMATION FOR SEQ ID NO: 693.

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 71 ammo acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...71

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 693:

Pro Ser Phe Leu Lys Glu Lys Phe Asp Phe Phe Lys Gly Lys Asn Phe

1 5 10 15

Lys He Val Tyr Cys He Gly Glu Asp Leu Thr Thr Arg Glu Lys Gly

20 25 30

Phe Arg Ala Val Lys Glu Phe Leu Ser Glu Gin Leu Glu Asn He Asp

35 40 45

Leu Asn Tyr Ser Asn Leu He Val Ala Tyr Glu Pro He Trp Ala He

50 55 60

Gly Thr Lys Lys Ala Arg Phe 65 70

(2) INFORMATION FOR SEQ ID NO: 694:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 155 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...155

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 694:

Arg Asp Val Arg Phe His Val Arg Asp Leu Val Arg Gin Leu Lys Gly

1 5 10 15

Lys His Leu He Glu Val Ser Asp Val He Asn Asp Thr Thr Gin Pro

20 25 30

Asn Leu Asp Met Asn Leu Leu Thr Thr Glu He Ala Arg Gin Leu Arg

35 40 45

Leu Arg Ser Asn Gly Arg Phe Asn He Thr Arg Ala Ser Gly Gly Ser

50 55 60

Gly He Glu Ala Asp Ser Arg Met Val Lys Gin Arg Glu Lys Glu Arg 65 70 75 80

Glu Ser Glu Glu Tyr Asn Gin Asp Thr Thr Val Glu Lys Gly Thr Leu

85 90 95

Lys Ala Ala Asp Leu Ser Leu Ser Gly Lys Val Ser Ser He Ala Ala 100 105 110 Ser He Ser Ser Ser Arg Gin Arg Leu Asp Tyr Asp Phe Thr Leu Ser

115 120 125

Leu Thr Asn Arg Lys Thr Gly Glu Glu Val Trp Ser Asp Val Lys Pro

130 135 140

He Val Lys Asn Ala Ser Asn Lys Arg Met Phe

145 150 155

(2) INFORMATION FOR SEQ ID NO: 695:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 219 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...219

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 695 :

He Lys Ser Val Leu Gly Leu He Leu He Gin Gin Asn Phe Lys Thr

1 5 10 15

Leu Lys Glu Leu Tyr Met Leu Val Thr Lys Leu Ala Pro Asp Phe Lys

20 25 30

Ala Pro Ala Val Leu Gly Asn Asn Glu Val Asp Glu His Phe Glu Leu

35 40 45

Ser Lys Asn Leu Gly Lys Asn Gly Val He Leu Phe Phe Trp Pro Lys

50 55 60

Asp Phe Thr Phe Val Cys Pro Thr Glu He He Ala Phe Asp Lys Arg 65 70 75 80

Val Lys Asp Phe His Glu Lys Gly Phe Asn Val He Gly Val Ser He

85 90 95

Asp Ser Glu Gin Val His Phe Ala Trp Lys Asn Thr Pro Val Glu Lys

100 105 110

Gly Gly He Gly Gin Val Ser Phe Pro Met Val Ala Asp He Thr Lys

115 120 125

Ser He Ser Arg Asp Tyr Asp Val Leu Phe Glu Glu Ala He Ala Leu

130 135 140

Arg Gly Ala Phe Leu He Asp Lys Asn Met Lys Val Arg His Ala Val 145 150 155 160

He Asn Asp Leu Pro Leu Gly Arg Asn Ala Asp Glu Met Leu Arg Met

165 170 175

Val Asp Ala Leu Leu His Phe Glu Glu His Gly Glu Val Cys Pro Ala

180 185 190

Gly Trp Arg Lys Gly Asp Lys Gly Met Lys Ala Thr His Gin Gly Val

195 200 205

Ala Glu Tyr Leu Lys Glu Asn Ser He Lys Leu 210 215

(2) INFORMATION FOR SEQ ID NO: 696: (1) SEQUENCE CHARACTERISTICS.

(A) LENGTH: 113 ammo acids

(B) TYPE, ammo acid (D) TOPOLOGY, linear

(ii) MOLECULE TYPE, protein

(ill) HYPOTHETICAL. YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...113

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 696 :

Gly Val He Met Glu Hi s His Lys Ala Hi s Thr Thr He Gin Ala Leu

1 5 10 15

Gin Ala Lys Arg Lys Arg Leu Leu Thr Glu Leu Ala Glu Leu Glu Ala

20 25 30

Glu He Lys Val Ser Ser Glu Arg Arg Ser Ser Phe Asn Val Ser Leu

35 40 45

Ser Pro Ser Leu Leu Ala Glu He Glu Glu He Glu Tyr Glu Glu Lys

50 55 60

Met Ser Lys Glu Arg Arg He His His Asn Leu Leu Leu Ser Pro Ser 65 70 75 80

Phe Met Ala Lys Val Asp Glu Tyr Met Lys Glu Lys Gly Phe Pro Asn

85 90 95

Arg Ser Leu Leu Phe Glu Lys Ala Leu Glu Phe Tyr Met Leu Lys His

100 105 110

Pro

(2) INFORMATION FOR SEQ ID NO: 697:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 187 ammo acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM. Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...187

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 697: Gly Phe Val Cys Gly Ser Val Leu Phe Gin Leu Gly Val Phe Met Gly 1 5 10 15

Leu Lys Asn Lys He Lys Gly Phe Val Lys Glu Arg Met Pro Phe Val

20 25 30

Met Arg Cys Val Arg Gly Leu Lys Gly Ala Lys Asp Thr His Glu Asn

35 40 45

Ala His Asp Arg Asp Ala Tyr Cys Gly He Asn Arg Glu He Lys Glu

50 55 60

Met Leu Glu Ala Lys Lys Leu His Phe Leu Gin Glu Lys Ala Leu Phe 65 70 75 80

Asn His Asp His Gin Glu Ser Val Phe Leu Ala He Ala Ser Leu Asn

85 90 95

Asn Glu Ser Phe He Glu Tyr Asn Lys Ser He Tyr Lys Asn Ser Ser

100 105 110

Leu Asn Tyr Asn Tyr Gly Gly His Leu Glu Asp Arg Val He His Pro

115 120 125

Thr Leu Thr Leu Pro Asn Pro Thr His Ser Gly Tyr Phe Asp Tyr Asp

130 135 140

Lys Lys Ser Gin Asn Pro Lys Ser Pro Leu Asn Pro Trp Ala Phe He 145 150 155 160

Arg Val Lys Asn Glu He Val Thr Leu Glu Glu Ser Leu Phe Ser Met

165 170 175

Leu Pro Ala Val Gin Arg Gly Gly His Trp Phe 180 185

(2) INFORMATION FOR SEQ ID NO: 698:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 230 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...230

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 698 :

Lys Arg Val Cys Phe Leu Cys Phe Leu Pro Phe Lys Gly Gly Val He

1 5 10 15

Gly Phe Asn Asp Cys Asp Asp Gly Ser Lys Glu Val Val Leu Glu Phe

20 25 30

Cys Lys Lys Phe Pro Ser Phe He Pro He Ser Tyr Pro Tyr Glu Val

35 40 45

He Leu Lys Asp Cys Pro Ser Leu Trp His Gin Leu Tyr His Tyr Cys

50 55 60

Asn Tyr Thr Leu Ser Phe He Pro Lys Asn Glu Trp Val Val Lys He

65 70 75 80

Asp Cys Asp His He Tyr Asp Ala Lys Lys Leu Tyr Lys Ser Phe Tyr

85 90 95

He Pro Lys Asn He Lys Glu Val Val Met Tyr Ser Arg He Asn Phe 100 105 110

Val Val Arg Asp Phe Glu Val Phe Val Arg Asn Asp Gly Asp Phe Gly

115 120 125

Phe Leu Asp Ala Trp Gly Asp His Trp Leu Leu Tyr Asn Asp Cys Glu

130 135 140

Pro Phe Glu He Trp Arg Tyr Asn Asp Glu Ser Tyr Glu Val Leu Lys 145 150 155 160

Leu Lys Asp Lys His His He Lys Asp Lys Glu Met Val Gin Trp His

165 170 175

Phe Pro Leu Ala Lys Lys Arg Arg Asn Ala He Val Tyr Asp Asp Leu

180 185 190

He Pro Leu Glu Glu Phe Lys Lys Arg His Ala Asp Leu He Gly Thr

195 200 205

Arg He Glu Glu Ser Met Leu Asp Glu Lys Arg He Leu Glu Val Tyr

210 215 220

Gin Lys Phe Arg Leu Pro 225 230

(2) INFORMATION FOR SEQ ID NO: 699:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 86 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...86

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 699:

Leu Ser Leu Asn Lys Lys Met Met Phe Glu Leu Thr Lys Lys Thr Lys

1 5 10 15

Phe Asp Gly Glu Met He Gly Tyr Thr Glu Glu Leu Leu Thr Phe Leu

20 25 30

Val Arg Asp Phe Phe Asn Gly He Phe Lys Ser Lys Val He Pro Lys

35 40 45

Met Pro He Phe Cys Gly Asp Val Lys Cys Glu Asp Phe Asn Ala Leu

50 55 60

Arg Ser Leu Val Tyr Leu Ser Val Leu Glu Leu Glu Glu Thr He Asn 65 70 75 80

Pro Asn Lys He Pro Phe 85

(2) INFORMATION FOR SEQ ID NO: 700:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 164 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear (11) MOLECULE TYPE: protein

(m) HYPOTHETICAL . YES

(vi) ORIGINAL SOURCE-

(A) ORGANISM- Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...164

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 700:

Phe Ser Arg Lys Thr Asp Lys Asn Ala Gin Lys Asp Glu Gin Lys Asn

1 5 10 15

Glu Gin Glu Glu Gin Arg Arg Leu Arg Glu Gin Gin Arg Leu Lys Gin

20 25 30

Asn Gin Glu Asn Gin Glu Met Leu Lys Gly Leu Gin Gin Asn Leu Asn

35 40 45

Gin Phe Thr Gin Lys Leu Glu Ser Val Lys Asn Lys Thr Leu Asp Leu

50 55 60

Gin He Pro Lys Gin Asp Gly Val Asp Glu Lys Ala Tyr Gin Glu Trp 65 70 75 80

Tyr Ala Gin He Tyr Gin He Leu Tyr Lys Gly Trp Arg Gly Val Phe

85 90 95

Tyr His Lys Ala Ser Val Ser Val Leu He Met He Thr Lys Asp Gly

100 105 110

Glu Phe Asp Tyr Thr He Leu Ser Tyr Ser Asp Phe Lys Asp Tyr Asn

115 120 125

Lys Ser Val Met Thr Leu Leu Asp Asp Leu Lys Lys Val Asp Phe Pro

130 135 140

Pro Tyr Pro Gly Gly Asn Met He Ser He Lys Val Asn Phe Thr Thr 145 150 155 160

Lys Glu Glu Gin

(2) INFORMATION FOR SEQ ID NO: 701:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 68 ammo acids

(D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(m) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...68

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 701: Arg Ala Arg Leu Leu Arg Arg Lys Asn His Tyr Leu Glu Asn Lys Phe

1 5 10 15

Lys Asp Met Gly His Tyr Ala Ala Ser Asp Glu Val Asn Glu Lys Gin

20 25 30

Val Leu Lys Met Tyr Gin Glu Gly Tyr Ser Val Asp Ser He Ser Lys

35 40 45

Glu Phe Lys Val Ser Lys Gly Glu Val Glu Phe He Leu Asn Met Ala

50 55 60

Gly Leu Lys Trp 65

(2) INFORMATION FOR SEQ ID NO: 702:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 97 ammo acids

(B) TYPE- ammo acid (D) TOPOLOGY- linear

(ii) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...97

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 702 :

Thr Lys Leu Asp Thr He Ser Leu Lys Arg He Gin Met Glu Lys Leu

1 5 10 15

Pro Lys Lys Arg Val Ser Lys Thr Lys Ser Gin Lys Leu He His Ser

20 25 30

Leu Thr Thr Gin Lys Asn Arg Ala Phe Leu Lys Lys He Ser Ala Asn

35 40 45

Glu Met Leu Leu Glu Leu Glu Lys Gly Ala Phe Lys Lys Asn Glu Ala

50 55 60

Tyr Phe He Ser Asp Glu Glu Asp Lys Asn Tyr Val Leu Val Pro Asp 65 70 75 80

Asn Val He Ser Leu Leu Ala Glu Asn Ala Arg Lys Ala Phe Glu Ala

85 90 95

Arg

(2) INFORMATION FOR SEQ ID NO: 703:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 272 ammo acids

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...272

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 703 :

Arg Ser He Lys Met Lys Gin Ser Leu Arg Glu Gin Lys Leu Leu Lys

1 5 10 15

He Leu Glu Asn Asp Val Leu Thr He Leu Asp Ser Phe Ser Asn Tyr

20 25 30

Leu Phe Glu Leu Arg Glu Glu Leu Asp Phe He Glu Glu Glu Met Glu

35 40 45

Gly Glu He Thr Glu Gin Asn Leu Thr Ala Leu Tyr Asp Phe Ser Asn

50 55 60

Phe Leu Glu Asp His Val Asn Val Phe Tyr Glu Asn Val Leu Asn He 65 70 75 80

Asp Asp Val Lys Thr Glu His Leu Tyr Ser Gly Leu He Asp Ser Leu

85 90 95

Asn Ala Asn Leu His Phe Val Lys Ser Phe Leu Ser Asn Gin Asp Leu

100 105 110

Asp Phe Arg Phe Phe Lys Glu He Asn Asp Gly Gin Asp Pro Gin Lys

115 120 125

Thr Leu Ser Arg Leu He Pro Leu Gin Ser Gly Lys Asn Asp Ala Ser

130 135 140

Ser Phe Lys Ala Asn Asn Ser Phe Val Ser Leu Val Tyr Val Tyr Ala 145 150 155 160

Tyr Phe Met Leu Glu Thr He Arg Gin Ser Tyr Arg He Leu Arg Leu

165 170 175

Leu Glu Lys Pro He Asn Asn Asn He Ser Glu Asp Met Gin Ser Asp

180 185 190

He Glu Asn Phe Phe Val Gin Ala Asn Phe Leu Glu Tyr Tyr Val Gin

195 200 205

Asn Lys He Tyr Pro Thr Asn His Ala Tyr Asp Phe Thr His Leu He

210 215 220

Met Asp Ser He He Pro Asn Trp He Gin He Asp Met Ser Val Glu 225 230 235 240

Ala Lys Lys Lys Glu Leu Phe Glu Lys Tyr Phe Gin Asn He Asp Glu

245 250 255

Val Thr Asn Lys Met Leu Ala Gin Glu Asn Gin Asn Lys Asn Ser Asp 260 265 270

(2) INFORMATION FOR SEQ ID NO: 704:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 229 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori ( ix ) FEATURE :

(A) NAME/KEY: misc_feature

(B) LOCATION 1...229

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 704 :

Val Lys Gly Glu Lys Asn Ala Trp Tyr Leu Gly He Ser Tyr Gin Val

1 5 10 15

Gly Gin Ala Ser Gin Ser Val Lys Asn Pro Pro Lys Ser Ser Glu Phe

20 25 30

Asn Tyr Pro Lys Phe Pro Val Gly Lys Thr Asp Tyr Leu Ala Val Met

35 40 45

Gin Gly Leu Gly Leu Thr Val Gly Tyr Lys Gin Phe Phe Gly Glu Lys

50 55 60

Arg Trp Phe Gly Ala Arg Tyr Tyr Gly Phe Met Asp Tyr Gly His Ala 65 70 75 80

Val Phe Gly Ala Asn Ala Leu Thr Ser Asp Asn Gly Gly Val Cys Lys

85 90 ^• 95

Leu Asn Glu Pro Cys Ala Thr Lys Val Gly Thr Met Gly Asn Leu Ser

100 105 110

Asp Met Phe Thr Tyr Gly Val Gly He Asp Thr Leu Tyr Asn Val He

115 120 125

Asn Lys Glu Asp Ala Ser Phe Gly Phe Phe Phe Gly Ala Gin He Ala

130 135 140

Gly Asn Ser Trp Gly Asn Thr Thr Gly Ala Phe Leu Glu Thr Lys Ser 145 150 155 160

Pro Tyr Lys His Thr Ser Tyr Ser Leu Asp Pro Ala He Phe Gin Phe

165 170 175

Leu Phe Asn Leu Gly He Arg Thr His He Gly Gin His Gin Glu Phe

180 185 190

Asp Phe Gly Val Lys He Pro Thr He Asn Val Tyr Tyr Phe Asn His

195 200 205

Gly Asn Leu Ser Phe Thr Tyr Arg Arg Gin Tyr Ser Leu Tyr Val Gly

210 215 220

Tyr Arg Tyr Asn Phe 225

(2) INFORMATION FOR SEQ ID NO: 705:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 65 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...65

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:705: Ser Ala Val Val Glu Ser Val Val He Leu Lys He Asp He Asn Gin

1 5 10 15

Gly Arg Ser Cys Ser Leu Tyr Pro Thr Pro Lys Ser Val Ser Leu Val

20 25 30

Arg Asn Gin Ser Val Ala Tyr Glu He Leu Cys Glu Asn Gin Pro Leu

35 40 45

Trp He Glu Val Ser Thr Asn Leu Gly Gin Thr Leu Pro Phe Ser Leu

50 55 60

He 65

(2) INFORMATION FOR SEQ ID NO: 706:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 365 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...365

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 706:

Arg Phe Lys His Phe Arg Gly Gly Gly Phe Pro His His Asn Leu Asn

1 5 10 15

Ala Cys Gly Ala Lys Pro Thr Gly Gin Val Val Phe Tyr Pro Thr Asn

20 25 30

Ser Leu Leu Gly Ser Thr Ser Ser Asn Ser Asn Asn Gin Gin Gin Tyr

35 40 45

Asn Asn Thr Leu Leu Met Asn Thr Leu Gin Gly Glu Leu Ser Thr Asn

50 55 60

Asn Gin Asn Asn Pro Asn Gly Cys Ala Asn Gin He Gin Cys Leu Glu 65 70 75 80

Gin Phe He Gin Asn Leu Thr Pro Leu Ala Ala Thr Pro Thr Ser Thr

85 90 95

Asn Gin Ala Asn Gin Gin Val Gin Ala He Ala Gin Lys Leu Gin Ser

100 105 110

Val Ala He Asn Ala Leu Asp Asn Asn Ala He Asn Asn Thr Thr Tyr

115 120 125

Asn Leu Asn Asn Leu His Asn Ala Leu Asn Phe Gin Ala Tyr Gin Ser

130 135 140

Thr He Glu Gin Tyr Asn Asn Ala Leu Lys Gin He Ser Trp He Ser 145 150 155 160

Phe Ser Glu Pro Lys Asn Leu Leu Lys Asn Thr Ser Asn Asn Tyr Gin

165 170 175

He Gly Thr Val Thr Asn Asp Gin Gly Gin Asn He Ser Ala Tyr Asp

180 185 190

Cys Thr Ser Ala Thr Gly Ser Leu Ser Ser Asp Ala Ser Ser Gly He 195 200 205

Ser Cys Ser Ala Thr Ser Ser Thr Ser Asn Thr Asn Ser Phe Asp Asn

210 215 220

Ser Leu Val Ala Thr Ser Lys Val Gin Thr He Asn Gly Lys Glu Gin 225 230 235 240

He Gly Val Asn Ser Phe Asn Leu Val Ser Gin Val Trp Ser Val Tyr

245 250 255

Asn Ser Leu Lys Thr Ser Glu Glu Asn Leu Gin Lys Asn Ala Lys He

260 265 270

Leu Cys Asn Asn Gly Ser Gin Ser Gly Thr Ser Pro Cys Asn Ser Ser

275 280 285

Ser Gly Gly Leu Ser He Ser Gly Asn Ala Gin Leu Gin Asn He Leu

290 295 300

Ser Pro Thr Asn Gly Thr Thr Thr Asn Thr Gin Ala Lys Ser Asn Ala 305 310 315 320

Ser Lys Leu Lys Ala Met Val Met Val Asn Asn Glu Glu Glu Ala Lys

325 330 335

Thr Thr Asn Phe Asn Gin Ser Ser Gly Pro Thr Thr Gin Ser Ser Asn

340 345 350

Ser Thr Val Met Gly Ala Leu Asn Thr Val Leu Gin Asn 355 360 365

(2) INFORMATION FOR SEQ ID NO: 707:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 135 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...135

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 707 :

Asn Pro Phe Phe Thr He Thr Ala Lys Leu Leu Ser Asn Thr Gin Ser

1 5 10 15

Ala Phe Asp Gin Gly He Ala Leu Ser Ser Asn He He Ser Ala Val

20 25 30

Asn Ser Leu Asn Pro Ser Asn Asn Ser Gin Glu Val Lys Ala Gin Leu

35 40 45

Gin Asn Thr Ala Gin Ser Met Thr Glu Leu Leu Gin Gin He Glu His

50 55 60

Ser He Thr Lys Thr Thr Ser Thr Thr Tyr Ala Gin Ser Leu Leu Ser 65 70 75 80

Asn Leu Thr Asp Ala Val Asn Ala Ser Ser Asn Asn Thr Thr Tyr Val

85 90 95

Ser Ala Leu Val Asn Ala Leu Asn Thr Leu Gly Val Gly Val Phe Pro

100 105 110

Thr Thr Thr Ser Thr His Val Val Leu Asn Pro Pro Asp Lys Ser Tyr 115 120 125

Ser He Gin Leu He Pro Phe 130 135

(2) INFORMATION FOR SEQ ID NO: 708:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 91 ammo acids

(D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...91

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 708:

Gly Arg Gly Met Lys Leu Lys Lys Arg Lys Val Ala Ala Thr Leu Leu

1 5 10 15

Lys Arg Leu Thr Leu Pro Leu Leu Phe Thr Thr Gly Ser Leu Gly Ala

20 25 30

Val Thr Tyr Glu Val His Gly Asp Phe He Asn Phe Ser Lys Val Gly

35 40 45

Phe Asn Arg Ser Pro He Asn Pro Val Lys Gly He Tyr Pro Thr Glu

50 55 60

Thr Phe Val Asn Leu Thr Gly Lys Leu Glu Gly Ser Val His Leu Gly

65 70 75 80

Arg Gly Trp Thr Val Asn Val Gly Gly Val Leu 85 90

(2) INFORMATION FOR SEQ ID NO: 709:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 721 ammo acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(Vl ) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...721

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:709: Met Glu Gin Pro Val He Lys Glu Gly Thr Leu Ala Leu He Asp Thr

1 5 10 15

Phe Ala Tyr Leu Phe Arg Ser Tyr Tyr Met Ser Ala Lys Asn Lys Pro

20 25 30

Leu Thr Asn Asp Lys Gly Phe Pro Thr Gly Leu Leu Thr Gly Leu Val

35 40 45

Gly Met Val Lys Lys Phe Tyr Lys Asp Arg Lys Asn Met Pro Phe He

50 55 60

Val Phe Ala Leu Glu Ser Gin Thr Lys Thr Lys Arg Ala Glu Lys Leu 65 70 75 80

Gly Glu Tyr Lys Gin Asn Arg Lys Asp Ala Pro Lys Glu Met Leu Leu

85 . 90 95

Gin He Pro He Ala Leu Glu Trp Leu Gin Lys Met Gly Phe Thr Cys

100 105 110

Val Glu Val Gly Gly Phe Glu Ala Asp Asp Val He Ala Ser Leu Ala

115 120 125

Thr Leu Ser Pro Tyr Lys Thr Arg He Tyr Ser Lys Asp Lys Asp Phe

130 135 140

Asn Gin Leu Leu Ser Asp Lys He Ala Leu Phe Asp Gly Lys Thr Glu 145 150 155 160

Phe Leu Ala Lys Asp Cys Val Glu Lys Tyr Gly He Leu Pro Ser Gin

165 170 175

Phe Thr Asp Tyr Gin Gly He Val Gly Asp Ser Ser Asp Asn Tyr Lys

180 185 190

Gly Val Lys Gly He Gly Ser Lys Asn Ala Lys Glu Leu Leu Gin Arg

195 200 205

Leu Gly Ser Leu Glu Lys He Tyr Glu Asn Leu Asp Leu Ala Lys Asn

210 215 220

Leu Leu Ser Pro Lys Met Tyr Gin Ala Leu He Gin Asp Lys Gly Ser 225 230 235 240

Ala Phe Leu Ser Lys Glu Leu Ala Thr Leu Glu Arg Gly Cys He Lys

245 250 255

Glu Phe Asp Phe Leu Ser Cys Ala Phe Pro Ser Glu Asn Pro Leu Leu

260 265 270

Lys He Lys Asp Glu Leu Lys Glu Tyr Gly Phe He Ser Thr Leu Arg

275 280 285

Asp Leu Glu Asn Ser Pro Phe He Val Glu Asn Val Pro He Leu Asn

290 295 300

Ser Thr Pro He Leu Asp Asn Thr Pro Ala Leu Asp Asn Ala Pro Lys 305 310 315 320

Lys Ser Arg Met He Val Leu Glu Ser Ala Glu Pro Leu Ser Met Phe

325 330 335

Leu Glu Lys Leu Glu Asn Pro Asn Ala Arg Val Phe Met Arg Leu Val

340 345 350

Leu Asp Lys Asp Lys Lys He Leu Ala Leu Ala Phe Leu Leu Gin Asp

355 360 365

Gin Gly Tyr Phe Leu Pro Leu Glu Glu Ala Leu Phe Ser Pro Phe Ser

370 375 380

Leu Glu Phe Leu Gin Asn Ala Phe Ser Gin Met Leu Gin His Ala Cys 385 390 395 400

He He Gly His Asp Leu Lys Pro Leu Leu Ser Phe Leu Lys Ala Lys

405 410 415

Tyr Gin Val Pro Leu Glu Asn He Arg He Gin Asp Thr Gin He Leu

420 425 430

Ala Phe Leu Lys Asn Pro Glu Lys Val Gly Phe Asp Glu Val Leu Lys

435 440 445

Glu Tyr Leu Lys Glu Asp Leu He Pro His Glu Lys He Lys Asp Phe 450 455 460

Lys Thr Lys Ser Lys Ala Glu Lys Ser Glu Leu Leu Ser Met Glu Leu 465 470 475 480

Asn Ala Leu Lys Arg Leu Cys Glu Tyr Phe Glu Lys Gly Gly Leu Glu

485 490 495

Glu Asp Leu Leu Thr Leu Ala Arg Asp He Glu Thr Pro Phe Val Lys

500 505 510

Val Leu Met Gly Met Glu Phe Gin Gly Phe Lys He Asp Ala Ala Leu

515 520 525

Glu Asn He Val He Ala Gly Val Thr Asn Lys Pro Asn Gly Ala Gly

530 535 540

Ala He Thr Ser Thr Gly His Val Thr Asp Tyr Ala Val Phe Asn Asn 545 550 555 560

He Lys Ala Met Leu Pro He Leu Gin Gin Ala Leu Thr Leu Ser Gin

565 570 575

Ser Asn His Thr Leu Ser Thr Gin Leu Gin Ala Arg Ala Met Gly Ser

580 585 590

Gin Thr Asn Arg Glu Phe Ala Lys Asp He Tyr Ala Leu Ala Gin Asn

595 600 605

Gin Lys Gin He Leu Ser Asn Ala Ser Ser He Phe Asn Leu Phe Asn

610 615 620

Ser He Pro Lys Asp Gin Leu Lys Tyr Leu Glu Asn Ala Tyr Leu Lys 625 630 635 640

Val Pro His Leu Gly Lys Thr Pro Thr Asn Pro Tyr Arg Gin Asn Val

645 650 655

Asn Leu Asn Lys Glu He Asn Ala Val Gin Asp Asn Val Ala Asn Tyr

660 665 670

Gly Asn Arg Leu Asp Ser Ala Leu Ser Val Ala Lys Asp Val Tyr Asn

675 680 685

Leu Lys Ser Asn Gin Thr Glu He Val Thr Thr Tyr Asn Asp Ala Lys

690 695 700

Asn Leu Gly Pro Gly Val Ser Lys Leu Pro Cys Arg Cys Leu Glu Lys 705 710 715 720

He

(2) INFORMATION FOR SEQ ID NO: 710:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 76 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

( B ) LOCATION 1...76

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 710: Thr Ser Leu Ser Leu Phe Gly Glu Asp Leu Ala Lys Glu Lys Arg Ser 1 5 10 15

He Ala Lys Ser He Asn Phe Gly Leu Val Tyr Gly Met Gly Ser Lys

20 25 30

Lys Leu Ser Glu Tnr Leu Ser He Pro Leu Ser Glu Ala Lys Ser Tyr

35 40 45

He Glu Ala Tyr Phe Lys Arg Phe Pro Ser He Lys Asp Tyr Leu Asn

50 55 60

Gly Met Arg Glu Glu He Leu Lys Thr Ser Lys Ala 65 70 75

(2) INFORMATION FOR SEQ ID NO: 711:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH- 325 ammo acids

(B) TYPE, ammo acid (D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...325

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 711:

Lys Glu Lys Asp Asn Pro Leu Gin Asn Phe Val Phe Asn Lys Lys Trp

1 5 10 15

Leu He Tyr Ser Ser Leu Leu Pro Leu Phe Phe Leu Asn Pro Leu Met

20 25 30

Ala Glu Asp Asp Gly Phe Phe Met Gly Val Ser Tyr Gin Thr Ser Leu

35 40 45

Ala Val Gin Arg Val Asp Asn Ser Gly Leu Asn Ala Ser Gin Asp Ala

50 55 60

Ser Thr Tyr He Arg Gin Asn Ala He Ala Leu Glu Ser Ala Ala Val 65 70 75 80

Pro Leu Ala Tyr Tyr Leu Glu Ala Met Gly Gin Gin Thr Arg Val Leu

85 90 95

Met Gin Met Leu Cys Pro Asp Pro Ser Lys Arg Cys Leu Leu Tyr Ala

100 105 110

Gly Gly Tyr Gin Asn Gly Gin Asn Asn Asn Gly Asp Thr Gly Asn Asn

115 120 125

Pro Pro Arg Gly Asn Val Asn Ala Thr Phe Asp Met Gin Ser Leu Val

130 135 140

Asn Asn Leu Asn Lys Leu Thr Gin Leu He Gly Glu Thr Leu He Arg 145 150 155 160

Asn Pro Glu Asn Leu Pro Asn Ser Lys Val Phe Asn Val Lys Phe Gly

165 170 175

Asn Gin Ser Thr Val He Ala Leu Pro Glu Gly Leu Ala Asn Thr Met

180 185 190

Asp Ala Leu Asn Asn Asp He Thr Asn Ala Leu Thr Thr Leu Trp Tyr

195 200 205

Asn Gin Thr Leu Thr Asn Lys Ser Phe Ser Thr Pro Ser Asn Thr Ser 210 215 220

Val Asn Phe Ser Pro Gin Val Leu Gin His Leu Leu Gin Asp Gly Leu 225 230 235 240

Ala Thr Ala Asn Asn Asn Gin Thr He Cys Ser Thr Gin Asn Gin Cys

245 250 255

Thr Ala Thr Asn Glu Ala Lys Ser He Ala Gin Asn Ala Gin Asn He

260 265 270

Phe Gin Ala Leu Met Gin Ala Gly He Leu Gly Gly Leu Ala Asn Glu

275 280 285

Lys Gin Phe Gly Phe Thr Tyr Asn Lys Ala Pro Asn Gly Gly Asp Ser

290 295 300

Gin Gin Gly Tyr Ser Lys Leu Cys Gly Pro Gly He Thr Pro Lys Arg 305 310 315 320

Gin His His Ala Ser 325

(2) INFORMATION FOR SEQ ID NO: 712:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 280 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...280

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 712 :

Tyr Asn Gin Met Gin Asp Val He Asn Tyr Gly Glu Ser Leu Leu Ser

1 5 10 15

Asn Thr Val Ala Tyr Gly Asp Phe He Thr Asn Trp Val Ala Pro Tyr

20 25 30

Leu Asp Leu Asn Asn Lys Gly Leu Asn Phe Leu Pro Asn Tyr Gly Gly

35 40 45

Gin Leu Asn Gly Ala Asn Asn Gin Thr Pro Gin Leu Thr Pro Gin Gin

50 55 60

Ala Gin Gin Glu Gin Lys Val He Met Asn Gin Leu Glu Gin Ala Thr 65 70 75 80

Asn Ala Pro Thr Pro Ala Gin He Asn Arg He Leu Ala Asn Pro Tyr

85 90 95

Ser Pro Thr Ala Lys Thr Leu Met Ala Tyr Gly Leu Tyr Arg Ser Lys

100 105 110

Ala Val He Gly Gly Val He Asp Glu Met Gin Thr Lys Val Asn Gin

115 120 125

Val Tyr Gin Met Gly Phe Ala Arg Asn Phe Leu Glu His Thr Leu Tyr

130 135 140

He Leu He Thr Leu Asn Gly Phe Gly Val Lys Met Gly Tyr Lys Gin 145 150 155 160

Phe Phe Gly Lys Lys Arg Met Phe Gly Leu Arg Tyr Tyr Gly Phe Tyr 165 170 175

Asp Phe Gly Tyr Ala Gin Phe Gly Thr Glu Ser Ser Leu Val Lys Ala

180 185 190

Thr Leu Ser Ser Tyr Gly Ala Gly Thr Asp Phe Leu Tyr Asn Val Phe

195 200 205

Thr Arg Lys Arg Gly Thr Glu Ala He Asp He Gly Phe Phe Ala Gly

210 215 220

He Gin Leu Ala Gly Gin Thr Trp Lys Thr Asn Phe Leu Asp Gin Val 225 230 235 240

Asp Gly Asn His Leu Lys Pro Lys Asp Thr Ser Phe Gin Phe Leu Phe

245 250 255

Asp Leu Gly He Met Asp Gin He Phe Pro Lys Ser Leu He Ser Lys

260 265 270

Lys Asn Leu Val Phe Leu Lys Gly 275 280

(2) INFORMATION FOR SEQ ID NO: 713:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 135 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...135

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 713 :

Gin Pro His Lys Gin Arg Asn He Ala His Leu Gin Hi s Ala Gin Ala

1 5 10 15

Val He Thr Ser Val Leu Ala Phe Trp Ser Leu Tyr Ala Gly Asn Ala

20 25 30

Leu Ser Phe His Val Thr Gly Leu Asn Asp Gly Ser Asn Ser Pro Leu

35 40 45

Gly Arg He His Arg Asp Gly Asn Cys Thr Gly Leu Gin Gin Cys Phe

50 55 60

Met Ser Lys Glu Thr Tyr Asp Lys Met Lys Thr Leu Ala Glu Asn Leu 65 70 75 80

Gin Lys Ala Gin Gly Asn Leu Cys Ala Leu Ser Glu Cys Ser Ser Asn

85 90 95

Gin Asp Ser Gly Phe Pro Val Leu Asp Ser Ala Gly Lys Gin Val Thr

100 105 110

He Thr He Thr Thr Gin Thr Asn Gly Ala Asn Lys Ser Glu Thr Thr

115 120 125

Thr Thr Thr Thr Thr Thr Asn 130 135

(2) INFORMATION FOR SEQ ID NO: 714: (l) SEQUENCE CHARACTERISTICS

(A) LENGTH. 124 ammo acids

(B) TYPE ammo acid (D) TOPOLOGY- linear

(n) MOLECULE TYPE- protein

(ill) HYPOTHETICAL. YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...124

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 714:

Gly Leu Ser Arg Gin Gly Asn Glu Arg Leu Asp Ala Thr Leu Asn Leu

1 5 10 15

Lys Thr Gly Val Gin Ser Phe Phe Lys Lys Tyr He Gly He Arg Gly

20 25 30

Val Phe Ala Trp Asp Leu Gly Ser Gly Lys Val Asn Tyr Gin Ser Tyr

35 40 45

Lys Asp Pro Thr Asn Ser Phe Phe Thr Met Leu Ala Val Gly Leu Asp

50 55 60

Val He Met Glu Phe Pro Leu Gly Ser Tyr Lys His Tyr Leu Gly Ala 65 70 75 80

Phe Gly Gly Ala Arg Gly Ala Leu Val Val Tyr Thr Asp Lys Gin Asn

85 90 95

Phe Lys Phe Phe Lys His Ser Val Val Ser Gly Gly Leu Ala He Ser

100 105 110

Gly Gly Trp Leu He Leu Leu Arg Thr Pro His Phe 115 120

(2) INFORMATION FOR SEQ ID NO: 715:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 103 ammo acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...103

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:715.

Pro Val Gly Leu Tyr Pro Leu Glu Ser Pro Leu He Tyr Glu Glu Asn 1 5 10 15 His Leu Leu Pro Met Gly Phe He His Leu Ala Phe Arg Gly Gly Gly

20 25 30

Ser Leu Ser Asp Lys Asn Gin Leu Gly Leu Ala Lys Leu Phe Ala Gin

35 40 45

Val Leu Asn Glu Gly Thr Lys Glu Leu Gly Ala Val Gly Phe Ala Gin

50 55 60

Leu Leu Glu Gin Lys Ala He Ser Leu Asn Val Asp Thr Ser Ala Glu 65 70 75 80

Asp Leu Gin He Thr Leu Glu Phe Leu Lys Glu Tyr Glu Asp Glu Ala

85 90 95

He Met Arg Leu Lys Glu Leu 100

(2) INFORMATION FOR SEQ ID NO: 716:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 85 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...85

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 716 :

Tyr Ser Val Tyr He Arg Ser Asn Phe Ser Lys Val Ala His Phe Ala

1 5 10 15

Ser Gly Tyr Leu Gin Thr Lys Leu Ser Thr Gin Ala Lys Ser Val Ala

20 25 30

Leu Ala Lys Lys Thr Thr Lys Glu Phe He Glu Lys Gly Met Thr Gin

35 40 45

Gin Glu Leu Asp Asp Ala Lys Lys Phe Leu Leu Gly Ser Glu Pro Leu

50 55 60

Arg Asn Glu Thr He Ser Ser Arg Leu Asn Thr Thr Tyr Asn Tyr Phe 65 70 75 80

He Trp Val Cys Leu 85

(2) INFORMATION FOR SEQ ID NO: 717:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 343 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...343

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 717 :

Arg Arg Ala Trp He Leu Leu Gly Leu Lys Asn Leu Lys Gly Val Trp

1 5 10 15

Val Leu Lys Gly Leu Lys Lys Ala Phe Lys Glu Arg Phe Cys Ser Gin

20 25 30

Val Tyr He Ser Phe Asn Val Asp His Asn Leu Leu Ser Ala Gin Val

35 40 45

Leu Arg Val Lys Asn His Arg He Lys Glu Lys Phe Phe Lys Thr Phe

50 55 60

Glu Thr Lys Val Glu Thr Lys Asn Gly Glu Val Pro He Gin Ala Leu 65 70 75 80

Lys He Ala Arg Thr Tyr Ser Gin Lys Tyr Pro Tyr Thr Tyr Phe Ser

85 90 95

Ala Met Ser Lys Ala Lys Glu Val Leu Cys Glu Lys Gin Ala Phe Glu

100 105 110

Gin He Lys Gin Glu Asn Gin Asp Tyr Gin Ala Cys Glu Val Asn Gin

115 120 125

Lys Tyr Cys Val Tyr Val Glu Ser Lys Asp Phe Leu Lys Asp Phe Lys

130 135 140

Arg Phe Lys He Gin Asp Val Asp Phe Leu Phe Ser Pro Phe Ser Leu 145 150 155 160

He Tyr Asp Phe Val Arg Asp Asn Leu Glu Asn Lys Pro Leu Leu Tyr

165 170 175

Leu Leu Leu Glu Arg Ser Arg Phe Tyr Phe Leu He Ala Asp Lys Lys

180 185 190

Glu He Phe Leu Ala Lys Ser Val Phe Leu Glu Glu Gin Pro Glu Glu

195 200 205

Phe He Glu Ser Lys Glu Glu Asp Ser Met Gly Met Asp Asn Glu Ala

210 215 220

Val Asp Leu Phe Leu Ser Glu He Gin Glu Asp He Asp Ser Leu Glu 225 230 235 240

Glu Ala He Gly Leu Asp Ser Ser Lys Asp Asn Ser Glu Lys He Thr

245 250 255

Glu As^'p Ala Tyr Ser Leu He Glu Gly Met Thr Asn He Pro Leu He

260 265 270

Ala Asp Val Leu Gin Glu Gly Leu Arg Gly Val Tyr His Ser Arg Glu

275 280 285

He Asp Phe Val Glu Lys Val Val Val Leu Asp Ser Cys Gin He His

290 295 300

His Lys Ala Leu Met His Leu Gin Glu Thr Leu Met He Glu Val Asp 305 310 315 320

Arg Leu Asp Phe Ser Leu Val Glu Arg Leu Asn Val Leu Ala Arg Met

325 330 335

Glu Asn Glu Lys His Ala Phe 340

(2) INFORMATION FOR SEQ ID NO: 718:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 420 ammo acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(ill) HYPOTHETICAL : YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...420

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 718 :

Met He Phe Gly Asp Phe Lys Tyr Gin Lys Ser Val Lys Lys Leu Thr

1 5 10 15

Ala Thr Asn Leu Asn Glu Leu Lys Asn Ala Leu Asp Phe He Ser Gin

20 25 30

Asn Arg Gly Lys Gly Tyr Phe Val Gly Tyr Leu Leu Tyr Glu Ala Arg

35 40 45

Leu Ala Phe Leu Asp Glu Asn Phe Gin Ser Gin Thr Pro Phe Leu Tyr

50 55 60

Phe Glu Gin Phe Leu Glu Arg Lys Lys Tyr Leu Val Glu His Leu Lys 65 70 75 80

Glu His Ala Phe Tyr Pro Lys He His Ser Ser Leu Asp Gin Lys Thr

85 90 95

Tyr Phe Lys Gin Phe Lys Ala Val Lys Glu His Leu Lys Asn Gly Asp

100 105 110

Thr Tyr Gin Val Asn Leu Thr Met Asp Leu Leu Leu Asn Thr Lys Ala

115 120 125

Lys Pro Lys Arg Val Phe Lys Glu Val He His Asn Gin Asn Thr Pro

130 135 140

Phe Lys Ala Phe He Glu Asn Glu Phe Gly Ser Val Leu Ser Phe Ser 145 150 155 160

Pro Glu Leu Phe Phe Glu Leu Glu Phe Leu Asp Thr Ala He Lys He

165 170 175

He Thr Lys Pro Met Lys Gly Thr He Ala Arg Ser Asn Asn Pro Leu

180 185 190

He Asp Glu Lys Asn Arg Leu Phe Leu Gin Asn Asp Asp Lys Asn Arg

195 200 205

Ser Glu Asn Val Met He Val Asp Leu Leu Arg Asn Asp Leu Ser Arg

210 215 220

Leu Ala Leu Lys Asn Ser Val Lys Val Asn Gin Leu Phe Glu He He 225 230 235 240

Ser Leu Pro Ser Val Tyr Gin Met He Ser Glu He Glu Ala Gin Leu

245 250 255

Pro Leu Lys Thr Ser Leu Phe Glu He Phe Lys Ala Leu Phe Pro Cys

260 265 270

Gly Ser Val Thr Gly Cys Pro Lys He Lys Thr Met Gin He He Glu

275 280 285

Ser Leu Glu Lys Arg Pro Arg Gly Val Tyr Cys Gly Ala He Gly Met

290 295 300

Val Gly Gly Lys Lys Ala Leu Phe Ser Val Pro He Arg Thr Leu Glu 305 310 315 320 Lys Arg Ala His Glu Asp Phe Leu His Leu Gly Val Gly Ser Gly Val

325 330 335

Thr Tyr Lys Ser Lys Ala Ser Lys Glu Tyr Glu Glu Ser Phe Leu Lys

340 345 350

Ser Phe Phe Val Met Pro Lys He Glu Phe Glu He Val Glu Thr Met

355 360 365

Arg Val lie Lys Arg Asp Gin Lys Leu Glu He Asn Asn Lys Asn Ala

370 375 380

His Lys Glu Arg Leu Met His Ser Ala Gin Tyr Phe Asn Phe Asn Thr 385 390 395 400

Asp Glu Asn Leu Leu Asp Phe Glu Leu Glu Gly Glu Gly Val Leu Arg

405 410 415

Val Leu He Gin 420

(2) INFORMATION FOR SEQ ID NO: 719:

(l) SEQUENCE CHARACTERISTICS.

(A) LENGTH: 285 ammo acids

(B) TYPE, ammo acid (D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(ill) HYPOTHETICA : YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...285

(xi ) SEQUENCE DESCRIPTION - SEQ ID NO : 719 :

Lys Gin He Arg Lys Glu Arg Leu Asn Lys Leu Leu Lys Lys Gly Phe

1 5 10 15

Leu Ala Phe Phe Leu Ser Val Tyr Leu Arg Ala Asp Asp Leu Val Thr

20 25 30

Tyr Thr He Ala Lys Glu Glu Asp Leu Gly Tyr Gin Arg Phe Leu Ala

35 40 45

Lys Lys Cys Leu Arg Gly Lys Thr His Pro Pro Cys Phe Thr Ala Ser

50 55 60

Lys Lys Pro Lys Arg Lys Pro Phe Asn He Asp Lys Ser Ser His Tyr 65 70 75 80

Tyr Gly Thr Ser Val Val Gin Met Ser Trp Leu Gin Ser Arg Glu Lys

85 90 95

Phe Glu Asn His Ser Lys Tyr Arg Asn He Pro Phe Ala Glu Val Ser

100 105 110

Leu He Tyr Gly Tyr Lys Gin Phe Phe Pro Lys Lys Glu His Tyr Gly

115 120 125

Phe Arg Phe Tyr Val Ser Leu Asp Tyr Ala Tyr Gly Phe Phe Leu Lys

130 135 140

Asn Lys Gly Ala Leu Gly Asp Ser Leu Arg Ala Ser Ser Gin He Pro 145 150 155 160

Lys Ser Tyr Arg Glu Lys Leu Gin Arg Lys Glu Thr Phe He Asn Ala 165 170 175 He Phe Tyr Gly Val Gly Ala Asp Phe Leu Tyr Lys Arg Ala Phe Gly

180 185 190

Thr Leu He Leu Gly Val Asn Phe Val Gly Glu Thr Trp Phe Tyr Glu

195 200 205

Thr Lys He Phe Lys Gin Trp Ala Lys Asp Ser Leu Asn Thr Tyr Arg

210 215 220

Pro Asn Met Phe Gin Val Met Leu Asn Val Gly Tyr Arg Tyr Arg Phe 225 230 235 240

Ser Arg Tyr Lys Asn Trp Ala He Glu Phe Gly Ala Arg He Pro Phe

245 250 255

Leu He Asn Asp Tyr Phe Lys Thr Pro Leu Tyr Thr Leu His Phe Lys

260 265 270

Arg Asn He Ser Val Tyr Leu Thr Ser Thr Tyr Asp Phe 275 280 285

(2) INFORMATION FOR SEQ ID NO: 720:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 231 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...231

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 720 :

Asn Thr Leu Phe Tyr Phe Phe Leu Leu Gin Ala Val He Val Leu Asp

1 5 10 15

Ser Phe Glu He Leu Lys Ala Leu Lys Ser Leu Asp Leu Leu Lys Asn

20 25 30

Ala Pro Ala Trp Trp Trp Pro Asn Ala Leu Lys Phe Glu Ala Leu Leu

35 40 45

Gly Ala Val Leu Thr Gin Asn Thr Lys Phe Glu Ala Val Leu Lys Ser

50 55 60

Leu Glu Asn Leu Lys Asn Ala Phe He Leu Glu Asn Asp Asp Glu He 65 70 75 80

Asn Leu Lys Lys He Ala Tyr He Glu Phe Ser Lys Leu Ala Glu Cys

85 90 95

Val Arg Pro Ser Gly Phe Tyr Asn Gin Lys Ala Lys Arg Leu He Asp

100 105 110

Leu Ser Lys Asn He Leu Lys Asp Phe Gin Ser Phe Glu Asn Phe Lys

115 120 125

Gin Glu Val Thr Lys Glu Trp Leu Leu Asp Gin Lys Gly He Gly Lys

130 135 140

Glu Ser Ala Asp Ala He Leu Cys Tyr Val Cys Ala Lys Glu Val Met 145 150 155 160

Val Val Asp Lys Tyr Ser Tyr Leu Phe Leu Lys Lys Leu Gly He Glu 165 170 175 He Glu Asp Tyr Asp Glu Leu Gin His Phe Phe Glu Lys Gly Val Gin

180 185 190

Glu Asn Leu Asn Ser Ala Leu Ala Leu Tyr Glu Asn Thr He Ser Leu

195 200 205

Ala Gin Leu Tyr Ala Arg Phe His Gly Lys He Val Glu Phe Ser Lys

210 215 220

Gin Lys Leu Glu Leu Lys Leu 225 230

(2) INFORMATION FOR SEQ ID NO: 721:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 231 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...231

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 721 :

He Ser Phe Asn Ala Asp Tyr Phe Arg He Trp Ala Arg Asp Phe Ala

1 5 10 15

Thr Gly Gin Tyr Ser Val Tyr Thr Ser Gly Pro Met Lys Gly Asn Val

20 25 30

Arg Pro He Asn Gly Tyr Ser Gin Gly Val Glu Leu Glu Leu Tyr Tyr

35 40 45

Arg Pro He Arg Gly Leu Gin Phe His Ala Ala Phe Asn Tyr He Asp

50 55 60

Thr Arg Val Thr Ser His Gly Pro Leu Thr Asp Leu Asn Gly Asp Val 65 70 75 80

Leu Lys Gly Thr Ser Tyr Asn Lys His Phe Pro Phe Val Ser Pro Phe

85 90 95

Gin Phe He Phe Asp Ala Arg Tyr Asn Trp Arg Lys Thr Thr He Gly

100 105 110

He Ser Ser Tyr Phe Tyr Ser Arg Ala Tyr Ser Gly He Ser Asn Ser

115 120 125

Ala Ala Gly Gly Tyr Tyr Gly Met Gin Tyr Tyr Ser Gly Gly Asn Asn

130 135 140

Tyr Glu Ser Val Leu Asn Ser Gly Tyr Gin Cys Glu Ala Trp Cys Met 145 150 155 160

Thr Gin His Glu Gly Leu Leu Pro Trp Tyr Trp Val Trp Asn He Gin

165 170 175

Val Ser Gin He Phe Trp Glu Asn Gly Arg His Arg Val Thr Gly Ser

180 185 190

Leu Gin He Asn Asn He Phe Asn Met Lys Tyr Tyr Phe Thr Gly He

195 200 205

Gly Ser Ser Pro Ala Gly Leu Gin Pro Ala Pro Gly Arg Ser Val Thr 210 215 220 Ala Tyr Leu Asn Tyr Thr Phe 225 230

(2) INFORMATION FOR SEQ ID NO: 722:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 268 ammo acids

(D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...268

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 722 :

Ser Gly Val Val Lys Met Lys Asp Lys Lys He Asp Glu Glu Thr Asn

1 5 10 15

Ala Val Leu Glu Gly Glu Lys Tyr Thr Val Cys Val Ser Cys Gin He

20 25 30

Gly Cys Gin Val Gly Cys Ser Phe Cys Phe Thr Gin Lys Gly Gly Phe

35 40 45

Val Arg Asp Leu Lys Ala Ser Glu He He Gin Gin Ala Leu Leu He

50 55 60

Lys Glu Ala Asn Asn Leu Pro He Glu Lys Ala Leu Asn He Val Phe 65 70 75 80

Met Gly Met Gly Glu Pro Leu Asn Asn Leu Asp Glu Val Cys Lys Ala

85 90 95

Val Glu He Phe Asn Thr Gly Met Gin He Ser Pro Lys Arg Val Thr

100 105 110

He Ser Thr Ser Gly Val Ala Asp Lys He Pro He Leu Ala Gly Lys

115 120 125

Asn Leu Gly Val Gin Leu Ala He Ser Leu His Ala Val Asp Asp Lys

130 135 140

Thr Arg Ser Ser Leu Met Pro Leu Asn Lys Lys Tyr Asn He Glu Cys 145 150 155 160

Val Leu Asn Glu Val Arg Lys Trp Pro Leu Glu Gin Arg Lys Arg Val

165 170 175

Met Phe Glu Tyr Leu Leu He Lys Asp Leu Asn Asp Ser Leu Asp Cys

180 185 190

Ala Lys Lys Leu Leu Lys Leu Leu Asn Gly He Lys Ser Lys Val Asn

195 200 205

Leu He Leu Phe Asn Pro His Glu Gly Ser Lys Phe Glu Arg Pro Ser

210 215 220

Leu Glu Ser Ala Arg Met Phe Ala Asn Phe Leu Asn Ala Lys Gly Leu 225 230 235 240

Leu Cys Thr He Arg Glu Ser Lys Ala Leu Asp He Glu Ala Ala Cys

245 250 255

Gly Gin Leu Arg Glu Lys Lys Leu Gin Gin Lys He 260 265 (2) INFORMATION FOR SEQ ID NO: 723:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 236 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...236

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 723 :

Arg Leu Ser Glu Pro He Asp Arg Phe Thr Arg He Arg Trp Leu Phe

1 5 10 15

Lys Asn Asp Phe Glu Lys He Arg Gin Gin Arg Val Leu He Cys Gly

20 25 30

Val Gly Gly Val Gly Gly Phe Ala Leu Asp Ser Leu Tyr Arg Val Gly

35 40 45

He Gly Gin He Thr He He Asp Lys Asp Met Phe Asp Val Thr Asn

50 55 60

Gin Asn Arg Gin He Gly Ser Glu Arg He Gly Glu Ser Lys Val Leu 65 70 75 80

Val Leu Gin Asp Leu Tyr Lys Gly He Gin Ala Leu Asn Cys Arg He

85 90 95

Asp Glu Ala Phe Leu Asn Ser Phe Asn Phe Arg Asp Tyr Asp Tyr He

100 105 110

Leu Asp Cys Met Asp Asp Leu Pro He Lys Thr Ser Leu Ala He Lys

115 120 125

Cys Gin Asn Phe Ala Tyr Gly Lys Phe He Ser Ser Met Gly Ser Ala

130 135 140

Lys Arg Leu Asn Pro Lys His He Gin Val Gly Ser Val Trp Glu Ser 145 150 155 160

Tyr Gly Asp Lys Phe Gly Arg Lys Phe Arg Asp Phe Leu Lys Lys Arg

165 170 175

Arg Phe Lys Gly Asp Phe Lys Val Val Phe Ser Pro Glu Val Pro His

180 185 190

Cys He Glu Leu Gly Ser Phe Asn Ala Val Thr Ala Ser Phe Gly Leu

195 200 205

Gin He Ala Ser Glu Val Val Gin Asp He He Lys Asn Glu Arg Gin

210 215 220

Trp Asn Glu Arg Leu Arg Arg Arg He Gly Arg Phe 225 230 235

(2) INFORMATION FOR SEQ ID NO: 724:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 333 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(11) MOLECULE TYPE: protein

( ll) HYPOTHETICAL : YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...333

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:724:

Ala Lys Ala Arg Val Gin Phe Asn Arg Ala Asn Glu Arg Gin Arg Arg

1 5 10 15

Ala Lys Glu Phe Tyr Tyr Glu Glu Val Gin Lys Ala He Lys Glu He

20 25 30

Asp Ser Ser Lys Lys His Asn He Asn Met Glu Arg Ser Arg Ala Glu

35 40 45

Val Ser Glu He Leu Asn Asn Thr Tyr Ser Asn Leu Asp Lys Tyr Glu

50 55 60

Ala Tyr Gin Gly Leu Leu Asn Pro Ala Val Ser Tyr Leu Ser Gly Leu 65 70 75 80

Phe Tyr Ala Leu Asn Gly Asp Lys Asn Lys Gly Leu Gly Tyr Leu Asn

85 90 95

Glu Ala Tyr Gly He Ser Gin Ser Pro Phe Val Ala Gin Asp Leu Val

100 105 110

Phe Phe Lys Asn Pro Asn Arg Ser His Phe Thr Trp He He He Glu

115 120 125

Asp Gly Lys Glu Pro Gin Lys Ser Glu Phe Lys He Asp Val Pro He

130 135 140

Phe Met He Asp Ser Val Tyr Asn Val Ser Val Ala Leu Pro Lys Leu 145 150 155 160

Glu Lys Gly Glu Ala Phe Tyr Gin Asn Phe Thr Leu Lys Asp Gly Glu

165 170 175

Lys Val Thr Pro Phe Asp Thr Leu Ala Ser He Asp Ala Val Val Ala

180 185 190

Ser Glu Phe Arg Lys Gin Leu Pro Tyr He He Thr Arg Ala He Leu

195 200 205

Ser Ala Thr Phe Lys Val Gly Met Gin Ala Val Ala Asn Tyr Tyr Leu

210 215 220

Gly Phe Val Gly Gly Leu Val Thr Ser Leu Tyr Ser Gly Val Ser Thr 225 230 235 240

Phe Ala Asp Thr Arg Asn Thr Ser He Phe Ala His Lys He Tyr Leu

245 250 255

Met Arg He Lys Asn Lys Ala Phe Glu Ser Tyr Glu Val Arg Ala Asp

260 265 270

Ser He Asp Ala Phe Ser Phe Ser Leu Lys Pro Cys Lys Arg Ser Leu

275 280 285

Glu Ser Pro Lys He He Asp Ala Arg Glu Leu Leu Ser Gly Phe Val

290 295 300

Thr Ala Pro Gin Val Phe Cys Ser Asn Arg His Asn He Leu Tyr Val 305 310 315 320

Arg Ser Phe Lys Asn Gly Phe Val Leu Ser His Leu Lys 325 330 (2) INFORMATION FOR SEQ ID NO.725:

(l) SEQUENCE CHARACTERISTICS.

(A) LENGTH: 91 ammo acids

(D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...91

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 725 :

Arg Asn Lys Asp Lys Arg Glu Tyr Phe Glu Asn Ala Thr Ala Gin He

1 5 10 15

Gly Ala Lys Leu Leu Val Cys Asp He Arg Glu Gin Phe Phe Asn Asp

20 25 30

Val Leu Phe Lys Pro Lys Tyr Gly Tyr Gly Lys Tyr Phe Asn Pro Cys

35 40 45

He Asp Cys His Ala Asn Met Phe Arg Asn Ala Phe Tyr Lys Met Leu

50 55 60

Glu Leu Asp Ala Asp Phe Val Leu Ser Gly Glu Val Leu Gly Asn Ala 65 70 75 80

Leu Asn Pro Lys Gly Lys Lys Arg Ser He Arg 85 90

(2) INFORMATION FOR SEQ ID NO: 726:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 302 ammo acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...302

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 726 :

Gly Glu Val Met Ala Asp Ser Leu Ala Gly He Asp Gin Val Thr Ser

1 5 10 15

Leu His Lys Asn Asn Glu Leu Gin Leu Leu Cys Phe Arg Leu Gly Lys 20 25 30

Asn Lys Asp Leu Tyr Ala Val Asn Val Phe Lys He Arg Glu Val Val

35 40 45

Lys Tyr His Gly Asn Leu Thr He He Ser His Glu Asn Asn Ser Leu

50 55 60

Val Glu Gly Leu He He He Arg Glu Leu Thr He Pro Leu He Asp 65 70 75 80

Met Lys Lys Trp Phe Tyr Tyr Asp Ser Gin Asn Lys Ser Lys Asp Leu

85 90 95

Arg Pro Tyr Arg He Gin Lys Glu Lys Ser Glu Asp Asp He Val Met

100 105 110

He Cys Glu Phe Ser Arg Trp Thr He Gly Val Arg He Tyr Glu Ala

115 120 125

Asp Arg He Ser Ser Lys Lys Trp Thr Glu Met Glu Gin Ser Ala Gly

130 135 140

Leu Arg Gly Ser Ala Gly Asn Asn Lys Leu Val Ser Arg Thr Arg Tyr 145 150 155 160

Phe Asp Gly Arg Leu Val Gin Val Val Asp He Glu Lys Met Leu He

165 170 175

Asp Val Phe Pro Trp He Glu Asp Glu Lys His Asn Asp Val Glu Thr

180 185 190

Leu Ser Lys He His Ser Asn Gin Cys Val Leu Leu Ala Asp Asp Ser

195 200 205

Pro Ser Val Leu Lys Thr Met Gin Met He Leu Asp Lys Leu Gly Val

210 215 220

Lys His He Asp Phe He Asn Gly Lys Thr Leu -Leu Glu His Leu Phe 225 230 235 240

Asn Pro Thr Thr Asp Val Ser Asn He Asp Leu He He Thr Asp Leu

245 250 255

Glu Met Pro Glu Ala Ser Gly Phe Glu Val He Asn Gin Val Lys Asn

260 265 270

Thr Pro Leu Thr Ser Thr He Pro He Val Val Asn Ser Ser Met Ser

275 280 285

Gly Ser Ser Tyr Glu Lys Asn Gly Lys Asn Leu Asn Gly Gin 290 295 300

(2) INFORMATION FOR SEQ ID NO: 727:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 126 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...126

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 727: Ala Val Ala Phe Cys Leu Pro Tyr Ser Ser Pro Lys Thr Ser Leu Ala 1 5 10 15

Thr Glu Leu His Tyr Ser Ala Asn Glu Arg He Glu Ala Phe Ser Ser

20 25 30

Asn Asp Glu Lys Thr Glu Ser Phe Glu Leu Asn Glu Gin Ser Phe Glu

35 40 45

Ala He Lys Glu Asn Ala Ala Lys Tyr Ser Tyr Leu Lys Val Tyr Leu

50 55 60

Lys Asn Val Ala Leu Lys Asp Ser Ala Pro Leu Val Phe Val Asp Met 65 70 75 80

Pro Gly Phe Asp Ser Pro He Ser Ser His Thr His Ala He Leu Glu

85 90 95

Tyr Leu Glu Arg Gly Val His Phe Val He Leu Thr Ser Val Glu Glu

100 105 110

Gly Asn Leu Thr Lys Arg Met Val Arg Glu Leu Lys Thr Phe 115 120 125

(2) INFORMATION FOR SEQ ID NO: 728:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 325 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...325

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 728 :

Arg Hi s Pro He Glu Asn Ser He Cys Asp Leu Ser Glu Leu Asn Asn

1 5 10 15

Leu Lys Pro Leu Gly Ala Glu Met Phe Val Gly Leu Asp Gly He Asp

20 25 30

Ala Met He Glu Glu Cys Val Ser Asn Leu Val He Asn Ala He Val

35 40 45

Gly Val Pro Gly Leu Lys Ala Ser Phe Lys Ser Leu Gin Arg Asn Lys

50 55 60

Lys Leu Ala Leu Ala Asn Lys Glu Ser Leu Val Ser Ala Gly His Leu 65 70 75 80

Leu Asp He Ser Gin He Thr Pro Val Asp Ser Glu His Phe Gly Leu

85 90 95

Trp Ala Leu Leu Gin Asn Lys Thr Leu Lys Pro Lys Ser Leu He He

100 105 110

Ser Ala Ser Gly Gly Ala Phe Arg Asp Thr Pro Leu Asp Leu He Ala

115 120 125

He Gin Asn Ala Gin Asn Ala Leu Lys His Pro Asn Trp Ser Met Gly

130 135 140

Asp Lys He Thr He Asp Ser Ala Ser Met Val Asn Lys Leu Phe Glu 145 150 155 160

He Leu Glu Thr Tyr Trp Leu Phe Gly Ala Ser Leu Lys He Asp Ala 165 170 175

Leu He Glu Arg Asn Ser He Val His Ala Leu Val Glu Phe Glu Asp

180 185 190

Asn Ser Val He Ala His Leu Ala Ser Ala Asp Met Gin Leu Pro He

195 200 205

Ser Tyr Ala He Asn Pro Lys Leu Ala Ser Leu Ser Ala Ser He Lys

210 215 220

Pro Leu Asp Leu Tyr Ala Leu Ser Ala He Lys Phe Glu Pro He Ser 225 230 235 240

Val Glu Arg Tyr Thr Leu Trp Arg Tyr Lys Asp Leu Leu Leu Glu Asn

245 250 255

Pro Lys Leu Gly Val Val Leu Asn Ala Ser Asn Glu Val Ala Met Lys

260 265 270

Lys Phe Leu Asn Gin Glu He Ala Phe Gly Gly Phe He Gin He He

275 280 285

Ser Gin Ala Leu Glu Leu Tyr Ala Lys Lys Ser Phe Lys Leu Ser Ser

290 295 300

Leu Asp Glu Val Leu Ala Leu Asp Lys Glu Val Arg Glu Arg Phe Gly 305 310 315 320

Ser Val Ala Arg Val 325

(2) INFORMATION FOR SEQ ID NO: 729:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 132 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...132

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 729:

Glu Thr Leu Ala Arg Val Leu Lys Val Ser Cys Leu Ala Met Gly Leu

1 5 10 15

Ala Gin Met Cys Cys Leu Thr Gin Leu Phe Ser He Val Arg Asn Leu

20 25 30

His Leu Gly Phe Phe Leu Gly Val Ala He Gly Gly Thr Ser Trp Gly

35 40 45

Pro Thr Asn Tyr Tyr Phe Lys Asp Leu Ala Glu Glu Tyr Arg Gly Ser

50 55 60

Phe His Pro Ser Asn Phe Gin Val Leu Val Asn Gly Gly He Arg Leu 65 70 75 80

Gly Thr Lys His Gin Gly Phe Glu He Gly Leu Lys He Gin Thr He

85 90 95

Arg Asn Asn Tyr Tyr Thr Ala Ser Ala Asp Asn Val Pro Glu Gly Thr

100 105 110

Thr Tyr Arg Phe Thr Phe His Arg Pro Tyr Ala Phe Tyr Trp Arg Tyr 115 120 125

He Val Ser Phe 130

(2) INFORMATION FOR SEQ ID NO: 730.

(l) SEQUENCE CHARACTERISTICS-

(A) LENGTH: 60 ammo acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

( x) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...60

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 730 :

Val Leu Lys Asn Glu He Ser Tyr Asn Lys Pro He Leu Asn Thr Asn

1 5 10 15

Asp Tyr Leu Asn Lys Asp Asn Thr Met Lys Asp Ser Phe Leu Phe Thr

20 25 30

Ser Glu Ser Val Thr Glu Gly His Pro Asp Lys Met Ala Asp Gin He

35 40 45

Ser Asp Ala Val Leu Asp Tyr Met He Glu Arg Asp 50 55 60

(2) INFORMATION FOR SEQ ID NO: 731:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 111 ammo acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(m) HYPOTHETICAL: YES

(vi ) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...111

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 731:

Lys Thr Lys Val Ala Cys Lys Thr Leu Val Ser Asn Gly Leu Cys Met 1 5 10 15

He Thr Gly Glu Leu Glu Thr Ser Val Tyr Ala Pro Met Leu Glu He 20 25 30 Ala Arg His Met Val Arg Lys He Gly Tyr Thr Asn Ala Leu Tyr Cys

35 40 45

Phe Asp Tyr Arg Ser Ala Ala Val Leu Asn Gly He Gly Glu Gin Ser

50 55 60

Pro Asp He Asn Gin Gly Val Asp Arg Glu Asp Gly Glu He Gly Ala 65 70 75 80

Gly Asp Gin Gly Leu Met Phe Gly Tyr Ala Cys Lys Glu Thr Glu Thr

85 90 95

Leu Met Pro Leu Pro He His Leu Ala His Gin Leu Ala Phe Ala 100 105 110

(2) INFORMATION FOR SEQ ID NO: 732:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 169 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...169

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 732:

Ser Leu Ser Thr Leu Ala Val Leu Leu Lys Ala Leu Asn Lys Arg Val

1 5 10 15

Phe Gin Thr He Leu Asn Ala Ala Lys Asp Lys Lys Glu Gly Ala He

20 25 30

Leu He Ala Ser Gly Cys Leu Ser Glu Arg Tyr Lys Asp Glu He Lys

35 40 45

Glu Leu He Pro Glu Val Asp He Phe Thr Gly Val Gly Asp Tyr Asp

50 55 60

Lys He Asp He Leu He Ala Lys Lys Gin Asn Gin Phe Ser Glu Gin 65 70 75 80

Val Phe Leu Ser Glu His Tyr Asn Ala Arg He He Thr Gly Ser Ser

85 90 95

Val His Ala Tyr Val Lys He Ser Glu Gly Cys Asn Gin Lys Cys Ser

100 105 110

Phe Cys Ala He Pro Ser Phe Lys Gly Lys Leu Gin Ser Arg Glu Leu

115 120 125

Asp Ser He Leu Lys Glu Val Glu Asp Leu Ala Leu Lys Gly Tyr Lys

130 135 140

Asp Met Thr Phe He Ala Gin Asp Ser Ser Ser Phe Leu Ser Asp Arg 145 150 155 160

Ala Lys Ser Arg Leu Asp Pro Ala His 165

(2) INFORMATION FOR SEQ ID NO: 733:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH. 158 ammo acids

(D) TOPOLOGY, linear

(ii) MOLECULE TYPE, protein

(ill) HYPOTHETICAL : YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...158

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 733 :

Asn Leu Arg Thr He Met Hi s Tyr Ser Tyr Glu Ala Phe Leu Lys Asp

1 5 10 15

Ser Leu Glu Leu Ala Lys Gin Val Glu Arg Leu Cys Gly He Pro Glu

20 25 30

Ala Leu Val Cys Val Met Arg Gly Gly Met Thr Leu Val His Phe Leu

35 40 45

Ser Leu His Trp Asn Leu Arg Glu Val Tyr Gly He Asn Ala He Ser

50 55 60

Tyr Asp Thr Thr Lys Arg Gin Asn Ala Leu Lys He Glu Asn Thr Pro 65 70 75 80

Thr He Lys Asp His Leu Lys Thr He Leu Val Val Asp Glu He Val

85 90 95

Asp Ser Gly Asn Ser Leu Glu Ala Val Leu Lys Val Leu Gin Asp Lys

100 105 110

His Pro Asp Lys Lys Phe Tyr Ser Ala Ser Leu Phe Gin Lys Thr Ser

115 120 125

Ala Lys Tyr Lys Ala Asp Ala Phe Leu Lys Asp Ala Pro Glu Trp He

130 135 140

Asp Phe Phe Trp Glu Val Asp Leu Lys Asn Leu Lys Ser His 145 150 155

(2) INFORMATION FOR SEQ ID NO: 734:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 227 ammo acids

(D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(in) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...227

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 734: Ser Ser Ser Leu Glu Arg Leu Pro Ala Ser Leu Lys Asp Ala Arg He

1 5 10 15

Leu Tyr Leu Tyr Pro Ser Ser Thr Thr Leu Glu Leu He Gly Ala He

20 25 30

Glu Asp Ser Pro He Phe Gin Asn Tyr Phe Tyr Met Pro He Gin His

35 40 45

He Ser Asp Ser Met Leu Lys Lys Met Arg Arg Asn Ser Ser Gin Ala

50 55 60

His His Leu Lys Leu Leu Asn Ala Met Lys Gin Val Lys Glu Ser Phe 65 70 75 80

He Arg Ser Thr He He Val Gly His Pro Glu Glu Asn Glu Ser Glu

85 90 95

Phe Glu Glu Leu Ser Ala Phe Leu Asp Glu Phe Arg Phe Asp Arg Leu

100 105 110

Asn He Phe Ala Phe Ser Ala Glu Glu Asn Thr His Ala Tyr Ser Leu

115 120 125

Glu Lys Val Pro Lys Lys He He Asn Ala Arg He Lys Ala Leu Asn

130 135 140

Lys He Ala Leu Lys His Gin Asn His Ser Phe Lys Ala Leu Leu Asn 145 150 155 160

Lys Pro He Lys Ala Leu Val Glu His Lys Glu Gly Glu Tyr Phe Tyr

165 170 175

Lys Ala Arg Asp Leu Arg Trp Ala Pro Glu Val Asp Gly Glu He Leu

180 185 190

He Asn Asp Ser Glu Leu Thr Thr Pro Leu Lys Pro Gly His Tyr Thr

195 200 205

He Val Pro Ser Ala Phe Lys Asp Asn He Leu Leu Ala Lys Val Leu

210 215 220

Ser Pro Phe 225

(2) INFORMATION FOR SEQ ID NO: 735:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 108 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...108

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 735 :

He Thr Asn Thr Thr Phe Gin Leu Gin Gly Val Leu Leu Glu Tyr Asp

1 5 10 15

Phe Glu Arg Pro Ala He Ser Tyr Thr Pro Lys Lys Ser Val Phe Asn

20 25 30

Glu Arg Leu Lys Asp Leu Arg Glu Asn Phe Ser Ala Ser Leu Tyr Ala 35 40 ^' 45

Asp Leu Lys Asp Lys He His His Asn Ala Leu Ser Asn Asp Asp Leu

50 55 60

Glu Arg Met He Ala Phe Arg Glu Gin Glu Phe Glu Lys Ser Leu Glu

65 70 75 80

Asp Trp Met Gly Ala Tyr Ser Tyr Asp Ala Thr Leu Arg Cys Phe Ser

85 90 95

Ser Glu Arg He Tyr Leu Asp Arg Leu Gly Trp Glu 100 105

(2) INFORMATION FOR SEQ ID NO: 736:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 364 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...364

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 736 :

Lys Lys Val Val Met Asn Gly Phe Cys Ala Arg Leu Arg Ala He Thr

1 5 10 15

Phe Asn Glu Arg Leu Lys Met Lys He Ala Val Leu Leu Ser Gly Gly

20 25 30

Val Asp Ser Ser Tyr Ser Ala Tyr Ser Leu Lys Glu Gin Gly His Glu

35 40 45

Leu Val Gly He Tyr Leu Lys Leu His Ala Ser Glu Lys Lys His Asp

50 55 60

Leu Tyr He Lys Asn Ala Gin Lys Ala Cys Glu Phe Leu Gly He Pro 65 70 75 80

Leu Glu Val Leu Asp Phe Gin Lys Asp Phe Lys Ser Ala Val Tyr Asp

85 90 95

Glu Phe He Asn Ala Tyr Glu Glu Gly Gin Thr Pro Asn Pro Cys Ala

100 105 110

Leu Cys Asn Pro Leu Met Lys Phe Gly Leu Ala Leu Asp His Ala Leu

115 120 125

Lys Leu Gly Cys Glu Lys He Ala Thr Gly His Tyr Ala Arg Val Lys

130 135 140

Glu He Asp Lys Val Ser Tyr He Gin Glu Ala Leu Asp Lys Thr Lys 145 150 155 160

Asp Gin Ser Tyr Phe Leu Tyr Ala Leu Glu His Glu Val He Ala Lys

165 170 175

Leu Val Phe Pro Leu Gly Asp Leu Leu Lys Lys Asp He Lys Pro Leu

180 185 190

Ala Leu Asn Ala Met Pro Phe Leu Gly Thr Leu Glu Thr Tyr Lys Glu

195 200 205

Ser Gin Glu He Cys Phe Val Glu Lys Ser Tyr He Asp Thr Leu Lys 210 215 220

Lys His Val Glu Val Glu Lys Glu Gly Val Val Lys Asn Leu Gin Gly 225 230 235 240

Glu Val He Gly Thr His Lys Gly Tyr Met Gin Tyr Thr He Gly Lys

245 250 255

Arg Lys Gly Phe Ser Val Lys Gly Ala Leu Glu Pro His Phe Val Val

260 265 270

Gly He Asp Ala Lys Lys Asn Glu Leu He Val Gly Lys Lys Glu Asp

275 280 285

Leu Ala Thr His Ser Leu Lys Ala Lys Asn Lys Ser Leu Thr Lys Asp

290 295 300

Phe Lys Asp Gly Glu Tyr Phe He Lys Ala Arg Tyr Arg Ser Val Pro 305 310 315 320

Thr Lys Ala Phe Val Ser Leu Lys Asp Gly Met He Glu Val Glu Phe

325 330 335

Lys Glu Pro Phe Tyr Gly Val Ala Lys Gly Gin Ala Leu Val Val Tyr

340 345 350

Lys Asp Asp He Leu Leu Gly Gly Gly Val He Val 355 360

(2) INFORMATION FOR SEQ ID NO: 737:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 133 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...133

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 737 :

Leu Phe Lys Thr Asn Gly He Ser Val Gly Glu Tyr Thr His Phe Ser

1 5 10 15

Glu Asp He Gly Ser Gin Ser Arg He Asn Thr Val Arg Leu Glu Thr

20 25 30

Gly Thr Arg Ser He Phe Ser Gly Gly Val Lys Phe Lys Ser Gly Glu

35 40 45

Lys Leu Val He Asn Asp Phe Tyr Tyr Ser Pro Trp Asn Tyr Phe Asp

50 55 60

Ala Arg Asn Val Lys Asn Val Glu He Thr Arg Lys Phe Ala Ser Ser 65 70 75 80

Thr Pro Glu Asn Pro Trp Gly Thr Ser Lys Leu Met Phe Asn Asn Leu

85 90 95

Thr Leu Gly Gin Asn Ala Val Met Asp Tyr Ser Gin Phe Ser Asn Leu

100 105 110

Thr He Gin Gly He Leu Ser Thr He Lys Arg Tyr His Leu Thr Lys

115 120 125

Gly Phe Phe Thr Pro 130 (2) INFORMATION FOR SEQ ID NO.738:

(l) SEQUENCE CHARACTERISTICS

(A) LENGTH. 82 ammo acids

(B) TYPE, ammo acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(m) HYPOTHETICAL ^• YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...82

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 738 :

Met Lys Lys Thr Arg He Arg Lys Lys Ser Ala Leu Met Asn Gly Cys

1 5 10 15

Trp Ala Glu Phe Asp Ser Val Phe Ser Ala He Val Pro Leu Glu Asp

20 25 30

Leu Asn Lys Thr Ala Cys Ala His His Ala Leu Lys Ala Leu Gin Ala

35 40 45

Thr Leu Lys Thr Thr He Trp Ala Leu Met Arg Gin Ser Trp Asn Arg

50 55 60

Ser Gin Lys Asp Ser Ser Leu Gly Gly He Cys Gly He Leu Thr Arg 65 70 75 80

Met Phe

(2) INFORMATION FOR SEQ ID NO: 739:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 105 ammo acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(ill) HYPOTHETICAL : YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...105

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 739:

Trp Thr Leu Ala Lys He Arg Cys Val Lys Asn Phe Lys Glu Ala He 1 5 10 15 Glu Gly Phe Thr Glu Lys He Lys Glu Ser Pro Asn Asp Ser Asn Ala

20 25 30

He Asn Glu Ala Phe Asp Asn Leu Glu Thr Glu Leu Glu Arg Ala Thr

35 40 45

Glu Asn Leu Ser Gin Lys He Asp Pro Val Leu Glu Arg Asn Glu Asn

50 55 60

Tyr Thr Gin Lys Ala Leu Glu Tyr Arg Glu Phe Leu Glu Ser Arg Lys 65 70 75 80

Glu Ser Phe He Val Asp Glu Lys Asn Pro Tyr Pro Glu Glu Val Ser

85 90 95

Phe Asn Glu Trp Leu Leu Gly Gly He 100 105

(2) INFORMATION FOR SEQ ID NO: 740:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 284 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...284

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 740 :

Arg Pro Leu Ala Leu He Met Trp Trp Arg Asn He Asp Asn Arg He

1 5 10 15

Ser He Lys Arg Val Val Asn Lys Pro Pro Arg Gly Leu Gly Lys He

20 25 30

Thr Gin Glu Trp He Phe Ser Leu Leu Asp Glu Glu Gly Leu Asn Leu

35 40 45

Glu Glu Ala Leu Lys He Gly Ala Phe Lys Asp Lys Leu Asn Pro Lys

50 55 60

Asn Glu Tyr Ala Leu Lys Lys Phe Thr Ala Met He Gly Arg Leu Arg 65 70 75 80

Glu Ala Phe Glu He Ser Val Glu Lys Phe Cys Glu Arg Phe Leu Glu

85 90 95

Glu Thr Asn Leu Leu Lys Ser Tyr Glu Lys Glu Asp Asn Tyr Glu Glu

100 105 110

Arg Glu Gly Phe Val Lys Glu Leu Leu Ser Leu Val Lys Glu His Phe

115 120 125

Lys Thr Asn Pro Thr His Ser Leu Leu Asp Phe Leu Asn Glu Ser Ala

130 135 140

Leu Asp Val His Asn Thr Glu Asn Ala Gin Lys Val Ser Cys Met Ser 145 150 155 160

Val His Met Ser Lys Gly Leu Glu Phe Lys His Val Phe Val He Gly

165 170 175

Leu Glu Glu Gly Phe Phe Pro His Arg Gly Phe Asn Gin Glu Ser Asp 180 185 190 Leu Glu Glu Glu Arg Arg Leu Ala Tyr Val Ala He Thr Arg Ala Lys

195 200 205

Glu Glu Leu Gin Leu Ser Tyr Val Lys Glu Arg Ser Tyr Phe Gly Arg

210 215 220

Lys He Ser Cys Ser Pro Ser Val Phe Leu Glu Glu Ala Gin Leu Leu 225 230 235 240

Gin Gin Asp Lys Pro Pro Lys Gin Asn His Gin Lys Asp Thr Pro He

245 250 255

Lys Val Gly Asp Leu He Lys His Lys He Phe Gly Thr Gly Glu Gly

260 265 270

Phe Arg Arg Arg Lys Arg Leu Ala Ala Val Cys Ala 275 280

(2) INFORMATION FOR SEQ ID NO: 741:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 242 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...242

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 741:

Asp Gly Ser Lys Lys Met Lys Ser Asn Lys Lys Ser Asn His Leu Arg

1 5 10 15

Ala He Tyr Arg Ala Leu Val He Ala He Gly Leu Ala Val He He

20 25 30

Val Phe Asn Tyr Phe Asn Arg Lys Asn Asn Asn Ala Arg Ser Ser Arg

35 40 45

Arg Ala Cys Ser Cys Phe Phe Pro Pro Thr Gly Val Asn Leu Glu Lys

50 55 60

He Gly Ser Phe Asp Thr Gly Ala Lys Leu He Val Leu Asn His Gin 65 70 75 80

Ser Leu Leu Asp He He Tyr Leu Glu Ala Tyr His Pro Ser Asn He

85 90 95

Cys Trp He Ala Lys Lys Glu Leu Gly Glu He Pro Phe Tyr Gly His

100 105 110

Ala Leu Thr Asp Thr Gly Met He Leu He Asp Arg Glu Asp Lys Lys

115 120 125

Gly He Val Ser Leu Leu Lys Ala Cys Lys Glu Lys Leu Asp Gin Asn

130 135 140

Arg Pro Leu Val He Phe Pro Glu Gly Thr Arg Gly Lys Gly Gly Glu 145 150 155 160

Lys Phe Leu Pro Phe Lys Gin Gly Ala Lys He He Ala Glu Lys Phe

165 170 175

Gin Leu Lys He Gin Pro Met Val Leu He Asn Ser He Lys He Phe 180 185 190 Asn Ser Lys Pro Leu Glu Ala Tyr Lys Ala Arg Thr Arg Leu Val Met

195 200 205

Leu Glu Ser Tyr Thr Pro Asp Phe Ser Ser Pro Thr Trp Tyr Glu Glu

210 215 220

Leu Gin Glu Arg Met Gin Lys Glu Tyr Leu Lys His Tyr His Glu Leu 225 230 235 240

Asn Ala

(2) INFORMATION FOR SEQ ID NO: 742:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 277 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...277

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 742 :

Val Met Lys Thr Ser Asn Thr Lys Thr Pro Lys Pro Val Leu He Ala

1 5 10 15

Gly Pro Cys Val He Glu Ser Leu Glu Asn Leu Arg Ser He Ala He

20 25 30

Lys Leu Gin Pro Leu Ala Asn Asn Glu Arg Leu Asp Phe Tyr Phe Lys

35 40 45

Ala Asn Phe Asp Asn Ala Asn Arg Thr Ser Leu Glu Ser Tyr Lys Glu

50 55 60

Pro Gly Leu Glu Lys Gly Leu Glu Met Leu Gin Thr He Lys Asp Glu 65 70 75 80

Phe Gly Tyr Lys He Leu Thr Asp Val His Glu Ser Tyr Gin Ala Ser

85 90 95

Val Ala Ala Lys Val Ala Asp He Leu Gin He Pro Ala Phe Leu Cys

100 105 110

Arg Gin Thr Asp Leu He Val Glu Val Ser Gin Thr Asn Ala He Val

115 120 125

Asn He Lys Lys Gly Gin Phe Met Asn Pro Lys Asp Met Gin Tyr Ser

130 135 140

Val Leu Lys Ala Leu Lys Thr Arg Asp Ser Ser He Gin Ser Pro Thr 145 150 155 160

Tyr Glu Thr Ala Leu Lys Asn Gly Val Trp Leu Cys Glu Arg Gly Ser

165 170 175

Ser Phe Gly Tyr Gly Asn Leu Val Val Asp Met Arg Ser Leu Lys He

180 185 190

Met Arg Glu Phe Ala Pro Val He Phe Asp Ala Thr His Ser Val Gin

195 200 205

Met Pro Gly Gly Ala Asn Gly Lys Ser Ser Gly Asp Ser Ser Phe Pro 210 215 220 Pro He Leu Pro Arg Ala Ala Ala Ala Val Gly He Asp Gly Leu Phe 225 230 235 240

Ala Glu Thr His He Asp Pro Lys Asn Ala Leu Ser Asp Gly Ala Asn

245 250 255

Met Leu Lys Pro Asp Glu Leu Glu His Leu Val Thr Asn Met Leu Lys

260 265 270

He Gin Asn Leu Phe 275

(2) INFORMATION FOR SEQ ID NO: 743:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 313 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...313

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 743 :

Gin Arg Asp Hi s Gly Val Leu Tyr Leu Leu Asn Asn Thr He He Lys

1 5 10 15

Phe Leu He Arg Arg Tyr He Met Leu Glu Asn Val Lys Lys Ser Leu

20 25 30

Phe Arg Val Leu Cys Leu Gly Ala Leu Cys Leu Gly Gly Leu He Ala

35 40 45

Glu Gin Asp Pro Lys Glu Leu Val Asn Leu Gly Thr Lys Ser Tyr Lys

50 55 60

Glu Gin Asp Phe Thr Gin Ala Lys Lys Tyr Phe Glu Lys Ala Cys Asp 65 70 75 80

Leu Lys Glu Asn Ser Gly Cys Phe Asn Leu Gly Val Leu Tyr Tyr Gin

85 90 95

Gly His Gly Val Glu Lys Asn Leu Lys Lys Ala Ala Ser Phe Tyr Ser

100 105 110

Lys Ala Cys Asp Leu Asn Tyr Ser Asn Gly Cys His Leu Leu Gly Asn

115 120 125

Leu Tyr Tyr Ser Gly Gin Gly Val Ser Gin Asn Thr Asn Lys Ala Trp

130 135 140

Gin Tyr Tyr Ser Lys Ala Cys Asp Leu Lys Tyr Ala Glu Gly Cys Ala 145 150 155 160

Ser Leu Gly Gly He Tyr His Asp Gly Lys Val Phe Thr Arg Asp Phe

165 170 175

Lys Lys Ala Val Glu Tyr Phe Thr Lys Ala Cys Asp Leu Asn Asp Gly

180 185 190

Asp Gly Cys Thr He Leu Gly Ser Leu Tyr Asp Ala Gly Arg Gly Thr

195 200 205

Pro Lys Asp Leu Lys Lys Ala Leu Ala Ser Tyr Asp Lys Ala Cys Asp 210 215 220 Leu Lys Asp Ser Pro Gly Cys Phe Asn Ala Gly Asn Met Tyr His His 225 230 235 240

Gly Glu Gly Ala Ala Lys Asn Phe Lys Glu Ala Leu Ala Arg Tyr Ser

245 ^• 250 255

Lys Ala Cys Glu Leu Glu Asn Gly Gly Gly Cys Phe Asn Leu Gly Ala

260 265 270

Met Gin Tyr Asn Gly Glu Gly Ala Thr Arg Asn Glu Lys Gin Ala He

275 280 285

Glu Asn Phe Lys Lys Gly Cys Lys Leu Gly Ala Lys Gly Ala Cys Asp

290 295 300

He Leu Lys Gin Leu Lys He Lys Val 305 310

(2) INFORMATION FOR SEQ ID NO: 744:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 529 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...529

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 744 :

Met Ser Ser Gly Leu He Tyr He Ser Leu Glu Val Leu Val Ala Cys

1 5 10 15

Leu He Thr Ala Leu He Met Tyr Tyr Val Met Lys Lys He Tyr Tyr

20 25 30

Ala Arg Gly Gin Ala He Leu Lys Gly Ala Ser Ala Lys Ala Lys Leu

35 40 45

Met Glu Phe Gin Ala Lys Ser Phe Val Glu Ala Glu Glu Met Arg Met

50 55 60

Lys Ser Gin Glu Cys Lys Leu Gin Gin Gin Tyr Glu Asn Lys Asn Leu 65 70 75 80

Gin Leu Gin Thr His Phe Asp Lys Lys Glu Ala His Leu Lys His Leu

85 90 95

Glu Ala Gin His Lys Glu Phe Val Arg Asp Glu Lys Arg Tyr Leu Glu

100 105 110

Lys Glu Lys Lys Glu Leu Glu Lys Glu Arg Gin He Leu Glu Gin Glu

115 120 125

Arg Glu Asn Phe Lys Lys Gin Arg Ala He Cys Lys Glu Ala Gin Ala

130 135 140

Lys Ala Leu Asp Ala Met Leu Asn Tyr Met Ala Tyr Thr Lys Asp Glu 145 150 155 160

He Lys Ser Met He Leu Glu Gin Leu Glu Glu Glu Leu Glu Ala Gin

165 170 175

Lys Ser Ala Leu He Arg Arg Tyr Glu Lys Glu Ala Lys Glu Glu Gly 180 185 190 Lys Lys Lys Ser Tyr Ala He Leu Ala Glu Ala Thr Ala Arg Phe Ala

195 200 205

Gly Asp Tyr Ala Thr Glu Asn Leu Thr Ser Arg He Ala Leu Pro Cys

210 215 220

Ser Asp Tyr Val Gly Arg Val He Gly Lys Asp Gly Lys Asn He Glu 225 230 235 240

Ala Phe Lys Lys He Ser Gly Val Asp He Glu Phe Ser Glu Asp Ser

245 250 255

Ser Glu Leu Cys Leu Ser Ser Phe Asn He Tyr Arg Arg Glu Val Ala

260 265 270

Ser Glu Thr He Lys He Leu He Glu Asp Gly Arg He Gin Pro Asn

275 280 285

Arg He Glu Glu Val Tyr His Arg Val Ala Arg Asn Met Glu Lys Glu

290 295 300

Leu Leu Ser Glu Gly Glu Ser Val Val Leu Glu Leu Glu Leu Gly Thr 305 310 315 320

Met Glu Asp Glu Leu Lys He Leu He Gly Lys Met Arg Tyr Arg Phe

325 330 335

Ser Phe Gly Gin Asn Ala Leu Gin His Ser Lys Glu Val Ala Leu Leu

340 345 350

Ala Gly Leu He Ala Glu Gin Leu Gly Gly Asp Lys Lys Leu Ala Arg

355 360 365

Arg Ala Gly He Leu His Asp He Gly Lys Ala Leu Thr Gin Glu Leu

370 375 380

Gly Arg Asp His Val Asn Leu Gly Val Glu Val Cys Lys Arg His Lys 385 390 395 400

Glu Asp Pro Val Val He Asn Ala He Tyr Ala His His Gly His Glu

405 410 415

Glu He Met Ser Val Glu Cys Ala Ser Val Cys Ala Ala Asp Ala Leu

420 425 430

Ser Ala Gly Arg Pro Gly Ala Arg Arg Lys Ser Asp Glu Glu Tyr Ala

435 440 445

Lys Arg Met Gin Ala Leu Glu Glu He Ala Leu Glu Phe Asp Gly Val

450 455 460

Glu Lys Ala Tyr Ala Met Glu Ser Gly Arg Glu Leu Arg Val He Val 465 470 475 480

Lys Ser Asn Gin Val Arg Asp Asn Gin Val Pro He He Ala Arg Lys

485 490 495

He Ala Lys Arg He Glu Glu Ser Thr Gin Tyr Val Gly Glu Val Gly

500 505 510

Val Gin Val Val Arg Glu Asn Arg Phe Lys Thr Thr Ala Thr Leu Lys

515 520 525

Gin

(2) INFORMATION FOR SEQ ID NO: 745:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 249 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE: (A) ORGANISM Helicobacter pylori

(ix) FEATURE.

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...249

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 745 :

Met Lys Lys Gly Ser Leu Ala He Val Leu Gly Ser Leu Leu Ala Ser

1 5 10 15

Gly Thr Phe Tyr Thr Ala Leu Ala Asp Gly Met Pro Met Lys Gin Gin

20 25 30

His Asn Asn Met Gly Glu Ser Val Glu Leu His Phe His Tyr Pro He

35 40 45

Lys Gly Lys Gin Glu Pro Lys Asn Asn His Leu Val Val Leu He Asp

50 55 60

Pro Lys He Glu Ala Asn Lys Val He Pro Glu Asn Tyr Gin Lys Glu 65 70 75 80

Phe Glu Lys Ser Leu Phe Leu Gin Leu Ser Asn Phe Leu Glu Arg Lys

85 90 95

Gly Tyr Ser Val Ser Gin Phe Lys Asp Val Ser Glu He Pro Gin Asp

100 105 110

He Lys Glu Lys Ala Leu Leu Val Leu Arg Met Asp Gly Asn Val Ala

115 120 125

He Leu Glu Asp He Val Glu Glu Ser Asp Ala Leu Ser Glu Glu Lys

130 135 140

Val He Asp Met Ser Ser Gly Tyr Leu Asn Leu Asn Phe Val Glu Pro 145 150 155 160

Lys Ser Glu Asp He He His Ser Phe Gly He Asp Val Ser Lys He

165 170 175

Lys Ala Val He Glu Arg Val Glu Leu Arg Arg Thr Asn Ser Gly Gly

180 185 190

Phe Val Pro Lys Thr Phe Val His Arg He Lys Glu Thr Asp His Asp

195 200 205

Arg Ala He Lys Lys He Met Asn Gin Ala Tyr His Lys Val Met Ala

210 215 220

His He Thr Lys Glu Leu Ser Lys Lys His Met Glu Arg Tyr Glu Lys 225 230 235 240

Val Ser Ser Glu Met Lys Lys Arg Lys 245

(2) INFORMATION FOR SEQ ID NO: 746:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 119 ammo acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_£eature ( B ) LOCATION 1 . . - 119

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 746 :

Met Gin Asn Thr Phe Asn Tyr Thr Asn Asn Ala Leu Lys Asn Asn Ala

1 5 10 15

Lys Leu Thr Pro Thr Glu Met Gin Ala Glu Gin Tyr Tyr Leu Gin Ser

20 25 30

Thr Leu Gin Asn He Glu Lys He Val Met Leu Ser Gly Gly Val Ala

35 40 45

Ser Asn Pro Lys Leu Val Gin Ala Leu Glu Lys Met Gin Glu Pro He

50 55 60

Thr Asn Pro Leu Glu Leu Val Glu Asn Leu Lys Asn Leu Glu Leu Gin 65 70 75 80

Phe Ser Gin Ser Gin Asn Ser Met Leu Ser Ser Leu Ser Ser Gin He

85 90 95

Ala Gin He Ser Asn Ser Leu Asn Ala Leu Asp Pro Ser Ser Tyr Ser

100 105 110

Lys Asn Val Ser Ser Met Tyr 115

(2) INFORMATION FOR SEQ ID NO: 747:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 314 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...314

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 747 :

Met Asp Leu Asp Lys Leu Lys Asp Tyr Arg Ala Leu Arg Asn Ala He

1 5 10 15

Leu Arg Leu Leu Pro Tyr Leu Asp Ser Gly He Thr Glu Leu He Met

20 25 30

Asn Lys Glu Lys Glu He Trp Leu Tyr Lys Leu Asn Gly Val Arg Glu

35 40 45

Lys Val Phe Asp Glu Asn Leu Asp Lys Ala Phe He Leu Gly Phe Gly

50 55 60

Glu Gin Leu Ala Ser Phe Arg Asp Leu Phe Phe Asn Ala Asn Tyr Pro 65 70 75 80

Thr Leu Asn Thr Ser He Pro Thr Ser Arg Tyr Arg Val Ser Met Asn

85 90 95

His Phe Ala He Ser Ala Asp Asn Glu Leu Ser Leu Asn He Arg Val

100 105 110

Pro Ser Asp Lys Lys Phe Asp Leu Lys Ala Phe Lys Leu Ser Ser He 115 120 125 Cys Gin Tyr Asp Tyr Glu Tyr Leu Lys Asn Leu Met He Asp Gly Lys

130 135 140

Asn Leu Leu He Ser Gly Gly Thr Gly Ser Gly Lys Thr Ser Phe Leu 145 150 155 160

Asn Ala Leu He Glu Phe He Pro Lys His Thr Arg He Val Ser Val

165 170 175

Glu Asp Ser Glu Glu Leu Asp Leu Arg Ala Phe Glu Asn His Lys Ser

180 185 190

Leu Leu Val Asp Lys Thr Glu Ser Ser Lys Phe Thr Tyr Glu Asn Ala

195 200 205

Leu Asn Met Ala Met Arg Met Ser Pro Asp Arg Leu Met Val Gly Glu

210 215 220

He Asp Thr Arg Asn Ser Met Leu Phe Leu Arg Phe Gly Asn Thr Gly 225 230 235 240

His Lys Gly Met Val Ser Thr Leu His Ala Asp Ser Val His Gly Val

245 250 255

He Glu Ala He Ala Leu Asn Leu Gin Met Asn Lys Ser Gly Leu Asp

260 265 270

Val Asn Val Ala Lys Lys Phe Phe Lys Ser Ser Val Asp Val Val Val

275 280 285

Gin He Val Leu Asp Lys Ala Thr Asn Thr Arg Tyr He Gin Glu He

290 295 300

Leu Pro Ala Lys Asp Leu Arg Asp Ser Leu 305 310

(2) INFORMATION FOR SEQ ID NO: 748:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 144 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...144

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 748 :

Met Asn He Ser Val Asn Pro Tyr Leu Met Ala Val Val Phe Val Val

1 5 10 15

Phe Val Leu Leu Leu Trp Ala Met Asn Val Trp Val Tyr Arg Pro Leu

20 25 30

Leu Ala Phe Met Asp Asn Arg Gin Ala Glu He Lys Asp Ser Leu Ala

35 40 45

Lys He Lys Thr Asp Asn Thr Gin Ser Val Glu He Gly His Gin He

50 55 60

Glu Thr Leu Leu Lys Glu Ala Ala Glu Lys Arg Arg Glu Met Leu Ala 65 70 75 80

Glu Ala He Gin Lys Ala Thr Glu Ser Tyr Asp Ala Val He Lys Gin

85 90 95 Lys Glu Asn Glu Leu Asn Gin Glu Phe Glu Ala Phe Ala Lys Gin Leu

100 105 110

Gin Asn Glu Lys Gin He Leu Lys Glu Gin Leu Gin Ala Gin Met Thr

115 120 125

Val Phe Glu Asp Glu Leu Asn Lys Arg Val Ala Met Gly Leu Gly Ser 130 135 140

(2) INFORMATION FOR SEQ ID NO: 749:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 91 ammo acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...91

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 749 :

Met Ala Ser Gly Leu Phe Glu Asn Asp Glu He Lys Asn Asn Lys Ala

1 5 10 15

Arg Asp Phe Phe Tyr Ser His Ser Ser Leu He Val Phe Phe Leu Leu

20 25 30

Leu Leu Gly Phe Gly Tyr Tyr Leu Gly Lys Leu Leu Phe Gly Gly Ser

35 40 45

Ser Leu Glu Val Tyr Leu Asp Leu Arg Asp Lys His Glu Arg Leu Gin

50 55 60

Gin Glu He Thr Glu Leu Gin Ser Lys Asn Val Arg Leu Gin Lys Arg 65 70 75 80

Leu Phe Glu Leu Arg Glu Leu Arg Pro Arg Asp 85 90

(2) INFORMATION FOR SEQ ID NO: 750:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 299 ammo acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: mιsc_feature

(B) LOCATION 1...299 ( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 750 :

Met Lys Lys Asn He Leu Asn Leu Ala Leu Val Gly Ala Leu Ser Ala

1 5 10 15

Ser Phe Leu Met Ala Lys Pro Ala His Asn Ala Asn Asn Ser Thr His

20 25 30

Asn Thr Lys Glu Thr Thr Asp Ala Ser Ala Gly Val Leu Ala Thr Val

35 40 45

Asp Gly Arg Pro He Thr Lys Ser Asp Phe Asp Met He Lys Gin Arg

50 55 60

Asn Pro Asn Phe Asp Phe Asp Lys Leu Lys Glu Lys Glu Lys Glu Ala 65 70 75 80

Leu He Glu Gin Ala He Arg Thr Ala Leu Val Glu Asn Glu Ala Lys

85 90 95

Ala Glu Lys Leu Asn Gin Thr Pro Glu Phe Lys Ala Met Met Glu Ala

100 105 110

Val Lys Lys Gin Ala Leu Val Glu Phe Trp Ala Lys Lys Gin Ala Glu

115 120 125

Glu Val Lys Lys He Gin He Pro Glu Lys Glu Met Gin Asp Phe Tyr

130 135 140

Asn Ala Asn Lys Asp Gin Leu Phe Val Lys Gin Glu Ala His Ala Arg 145 150 155 160

His He Leu Val Lys Thr Glu Asp Glu Ala Lys Arg He He Ser Glu

165 170 175

He Asp Lys Gin Pro Lys Ala Lys Lys Glu Ala Lys Phe He Glu Leu

180 185 190

Ala Asn Arg Asp Thr He Asp Pro Asn Ser Lys Asn Ala Gin Asn Gly

195 200 205

Gly Asp Leu Gly Lys Phe Gin Lys Asn Gin Met Ala Pro Asp Phe Ser

210 215 220

Lys Ala Ala Phe Ala Leu Thr Pro Gly Asp Tyr Thr Lys Thr Pro Val 225 230 235 240

Lys Thr Glu Phe Gly Tyr His He He Tyr Leu He Ser Lys Asp Ser

245 250 255

Pro Val Thr Tyr Thr Tyr Glu Gin Ala Lys Pro Thr He Lys Gly Met

260 265 270

Leu Gin Glu Lys Leu Phe Gin Glu Arg Met Asn Gin Arg He Glu Glu

275 280 285

Leu Arg Lys His Ala Lys He Val He Asn Lys 290 295

(2) INFORMATION FOR SEQ ID NO: 751:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 305 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE: (A) NAME/KEY: misc_feature

(B) LOCATION 1...305

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 751 :

Met He Lys Ser Trp Thr Lys Lys Trp Phe Leu He Leu Phe Leu Met

1 5 10 15

Ala Ser Cys Phe Gly His Leu Val Ala Thr Thr Gly Glu Lys Tyr Phe

20 25 30

Lys Met Ala Asn Gin Ala Leu Lys Arg Gly Asp Tyr His Arg Ala Val

35 40 45

Ala Phe Tyr Lys Arg Ser Cys Asn Leu Arg Met Gly Val Gly Cys Thr

50 55 60

Ser Leu Gly Ser Met Tyr Glu Tyr Gly Asp Gly Val Asp Gin Asn He 65 70 75 80

Ser Lys Ala Val Phe Tyr Tyr Arg Arg Gly Cys Asn Leu Arg Asn His

85 90 95

Leu Ala Cys Ala Ser Leu Gly Ser Met Tyr Glu Asp Gly Asp Gly Val

100 105 110

Gin Lys Asp Phe Pro Lys Ala He Tyr Tyr Tyr Arg Arg Gly Cys His

115 120 125

Leu Lys Gly Gly Val Ser Cys Gly Ser Leu Gly Phe Met Tyr Phe Asn

130 135 140

Gly Thr Gly Val Lys Gin Asn Tyr Ala Lys Ala Leu Ser Phe Ser Lys 145 150 155 160

Tyr Ala Cys Ser Leu Asn Tyr Gly He Ser Cys Asn Phe Val Gly Tyr

165 170 175

Met Tyr Lys Ser Ala Lys Gly Val Glu Lys Asp Leu Lys Lys Ala Leu

180 185 190

Ala Asn Phe Lys Arg Gly Cys His Leu Lys Asp Gly Ala Ser Cys Val

195 200 205

Ser Leu Gly Tyr Leu Tyr Glu Ala Gly Met Asp Val Lys Gin Asn Glu

210 215 220

Glu Gin Ala Leu Asn Leu Tyr Lys Lys Gly Cys Ser Leu Lys Glu Gly 225 230 235 240

Ser Gly Cys His Asn Val Ala Val Met Tyr Tyr Thr Gly Lys Gly Ala

245 250 255

Pro Lys Asp Leu Glu Lys Ala Thr Ser Tyr Tyr Lys Lys Gly Cys Ala

260 265 270

Leu Gly Phe Ser Gly Ser Cys Lys Val Leu Glu Val He Gly Lys Glu

275 280 285

Ser Asp Asn Leu Gin Asp Asp Ala Gin Asn Asp Thr Gin Asp Ser Val

290 295 300

Gin 305

(2) INFORMATION FOR SEQ ID NO: 752:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 502 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES (v ) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc eature

(B) LOCATION 1...502

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 752 :

Leu Lys He Phe Leu Val He Leu Ser Val Phe Phe Phe Asn Gly Cys

1 5 10 15

Phe Gly Leu Ala Tyr Lys Thr Pro He Ser Asn Pro Pro He Ser Tyr

20 25 30

Asp Pro Tyr Thr Thr Thr He Gly Ser Leu Tyr Ala Lys Asn Leu Lys

35 40 45

Glu Asn Pro Lys His Ser Ala Ala He Leu Leu Glu Asp Gly Phe Asp

50 55 60

Ala Leu Leu His Arg Val Gly Leu He Arg Met Ser Gin Lys Ser He 65 70 75 80

Asp Met Gin Thr Tyr He Tyr Lys Asn Asp Leu Ser Ser Gin Val He

85 90 95

Ala Lys Glu Leu Leu Asn Ala Ala Asn Arg Gly Val Lys Val Arg He

100 105 110

Leu Leu Asp Asp Asn Gly Leu Asp Ser Asp Phe Ser Asp He Met Leu

115 120 125

Leu Asn Phe His Lys Asn He Glu Val Lys He Phe Asn Pro Tyr Tyr

130 135 140

He Arg Asn Lys Gly Leu Arg Tyr Phe Glu Met Leu Ala Asp Tyr Glu 145 150 155 160

Arg He Lys Lys Arg Met His Asn Lys Leu Phe He Val Asp Asn Phe

165 170 175

Ala Val He He Gly Gly Arg Asn He Gly Asp Asn Tyr Phe Asp Asn

180 185 190

Asp Leu Asp Thr Asn Phe Leu Asp Leu Asp Ala Leu Phe Phe Gly Gly

195 200 205

Val Ala Ser Lys Ala Lys Glu Ser Phe Glu Asn Tyr Trp Arg Phe His

210 215 220

Arg Ser He Pro Val Ser Leu Leu Arg Thr His Lys Arg Leu Lys Asn 225 230 235 240

Asn Val Lys Glu He Ala Lys Leu His Glu Lys He Pro He Ser Ala

245 250 255

Glu Asp Ala Asn Glu Phe Glu Lys Lys Val Asn Asp Phe He Glu Arg

260 265 270

Phe Gin Lys Tyr Gin Tyr Pro He Tyr Tyr Gly Asn Ala He Phe Leu

275 280 285

Ala Asp Leu Pro Ala Lys He Asp Thr Pro Leu Tyr Ser Pro He Lys

290 295 300

He Ala Phe Glu Lys Ala Leu Lys Asn Ala Lys Asp Ser Val Phe He 305 310 315 320

Ala Ser Ser Tyr Phe He Pro Gly Lys Lys He Met Lys He Phe Lys

325 330 335

Asn Gin He Ser Lys Gly He Glu Leu Asn He Leu Thr Asn Ser Leu

340 345 350

Ser Ser Thr Asp Ala He Val Val Tyr Gly Ala Trp Glu Arg Tyr Arg

355 360 365

Asn Lys Leu Val Arg Met Gly Ala Asn Val Tyr Glu He Arg Asn Asp 370 375 380 Phe Phe Asn Arg Gin He Lys Gly Arg Phe Ser Thr Lys His Ser Leu 385 390 395 _, 400

His Gly Lys Thr He Val Phe Asp Asp Ala Leu Thr Leu Leu Gly Ser

405 410 415

Phe Asn He Asp Pro Arg Ser Ala Tyr He Asn Thr Glu Ser Ala Val

420 425 430

Leu Phe Asp Asn Pro Ser Phe Ala Lys Arg Val Arg Leu Ser Leu Lys

435 440 445

Asp His Ala Gin Gin Ser Trp His Leu Val Leu Tyr Arg His Arg Val

450 455 460

He Trp Glu Ala Thr Glu Glu Gly He Leu He His Glu Lys Asn Ser 465 470 475 480

Pro Asp Thr Ser Phe Phe Leu Arg Leu He Lys Glu Trp Ser Lys Val

485 490 495

Leu Pro Glu Arg Glu Leu 500

(2) INFORMATION FOR SEQ ID NO: 753:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 169 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL : YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...169

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 753:

Leu Lys Asn Leu Ser Thr Leu Leu Val Phe Leu Phe Phe Cys Leu Gly

1 5 10 15

Cys Val Ser Asn Phe Asn Glu Asp Thr Tyr Thr Leu Asp Leu Val Leu

20 25 30

Glu Lys Lys He Gin Ala Ser Arg Lys Gly Glu He Thr Gin Asp Asn

35 40 45

Val Pro He He Thr Ala He Ala Thr His Leu Asn Asp Val Asp Ser

50 55 60

Gly Thr Tyr Tyr Asp His Glu Tyr Phe Leu Val Glu He Phe Thr Gin 65 70 75 80

Asn Asn Asp Trp He Asp Asp Gly Tyr He Ser Tyr Glu Leu Phe Gly

85 90 95

Thr Lys Pro Thr Gly Ser Glu Pro Leu Trp Val Arg Glu He Thr Arg

100 105 110

Asp Glu Phe Asp Gly He Leu Glu Thr Thr Asn Arg Trp Ser Arg Ala

115 120 125

Phe Leu He Ala Phe Asp Lys Leu Asp Tyr Leu Ala Val Gin Glu Ala

130 135 140

Lys Leu Glu Leu Asp Ala Tyr Ser Leu Gly Lys He Val Phe Asn Phe 145 150 155 160 Ala Tyr Gin Val Pro Leu Pro Gin Phe 165

(2) INFORMATION FOR SEQ ID NO: 754:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 511 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...511

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 754 :

Met Lys Lys Leu Leu Tyr Thr Met Leu Ala Leu Leu Leu He Gly Leu

1 5 10 15

Leu Thr Ala Tyr Leu He Leu Phe Thr Glu Trp Gly Asn Lys He He

20 25 30

Ala Ser Tyr He Glu Lys Lys He Asn Pro Asn Glu Arg Tyr Leu Ser

35 40 45

Val Lys Thr Phe Lys Leu Arg Phe Asn Ser Leu Asp Phe Lys Ala Gin

50 55 60

Ala Asn Asp Asp Ser Thr Leu He Leu Lys Gly Asp Phe Ser Leu Leu 65 70 75 80

Thr Gin Ser Val Asn Leu Asp Tyr His He Asp He Lys Asn Leu Arg

85 90 95

Ser Phe Lys Asp Leu He Pro Tyr Pro Leu Arg Gly Ala He Val Thr

100 105 110

Ser Gly Asn He Lys Gly His Arg Lys Ala Leu Val Val Gin Gly Val

115 120 125

Ser Asn Val Ala Gin Ser His Thr Ala Tyr Asn Ala Leu Leu Asp Asp

130 135 140

Phe Lys Leu Ser His Leu Ser Leu Asn Ala Lys Asp Ala Asn Leu Glu 145 150 155 160

Asp Leu Leu Tyr Leu He Asn Arg Pro Ala Tyr Ala Asn Ala Lys Val

165 170 175

Ser Leu Gin Ala Asp Phe Asn Ser Leu Lys Pro Leu Glu Gly His Leu

180 185 190

He Leu Thr Ala Asn Asn Ala Leu He Asn Asn Ala Leu He Asn Gin

195 200 205

He Phe His Leu Asn Leu Lys Asp Thr Leu Val Phe Asn Leu Ser His

210 215 220

Ser Ser Asp Phe Lys Gly Asn Lys Ala He Ser Asp Thr Thr Leu Thr 225 230 235 240

Ser Pro Leu Val Asn Phe Thr Ala Leu Lys Ser Glu Tyr Ser Phe Pro

245 250 255

Ala Leu Lys Leu Asn Ala Pro Tyr Thr Leu Glu He Pro His Leu Ala 260 265 270 Lys Leu Gin Asn He Thr Asn His Pro Leu Lys Gly Ser Leu Thr Leu

275 280 285

Lys Gly Asp He Glu Gin Ser Pro Lys Leu Leu Lys Val Ser Gly His

290 295 300

Ser Asn Leu Leu Asp Gly Ala Leu Asp Phe Thr Leu Leu Asn Lys Asp 305 310 315 320

Leu Lys Ala Arg Phe Ser Asn He Ser Thr Ser Lys Ala Leu Asp Leu

325 330 335

Phe His Tyr Pro Lys Phe Phe Gin Ser He Ala Asp Ala Asn Leu Asp

340 345 350

Tyr Asp Leu He Ser Lys Gin Gly Val Leu Lys Ala Asn Leu Lys Asn

355 360 365

Ala Arg Phe Leu Lys Asn Ala Phe Ser Asp Phe Leu Tyr Ser He Ser

370 375 380

Arg Phe Asp He Thr Lys Glu He Tyr His Asp Ala Asn Leu Val Ser 385 390 395 400

Gin He Asn Gin Gin Arg Leu Leu Ser Asp Leu Ser Leu Lys Ser Pro

405 410 415

Lys Thr Gin Leu Lys He His Asn Gly Leu Leu Asp Leu Asn Thr Lys

420 425 430

Gin Met Asp He Leu Met Asp Ala Glu He Leu Lys Phe He Phe Lys

435 440 445

Met Lys Leu Gin Gly Ser Met His Gin Pro Lys Phe Ser Leu He Leu

450 455 460

Asn Glu Lys Ala He Gin Gin Asn Leu Gin Gin Gly Leu Lys Glu He 465 470 475 480

Leu Lys Asn Asp Thr Leu Lys Lys Gly Leu Asp His Leu Leu Lys Asp

485 490 495

Asp Lys Leu Lys Glu Lys Leu Glu Lys Gly Leu Lys Gly Leu Phe 500 505 510

(2) INFORMATION FOR SEQ ID NO: 755:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 160 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...160

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 755 :

Met Phe Gly Met Gly Phe Phe Glu He Leu Val Val Leu He Val Ala

1 5 10 15

He He Phe Leu Gly Pro Glu Lys Phe Pro Gin Ala Val Val Asp He

20 25 30

Val Lys Phe Phe Arg Ala Val Lys Lys Thr Leu Asn Asp Ala Lys Asp 35 40 45 Thr Leu Asp Lys Glu He Asn He Glu Glu He Lys Lys Glu Thr Leu

50 55 60

Glu Tyr Gin Lys Leu Phe Glu Asn Lys Val Glu Ser Leu Lys Gly Val 65 70 75 80

Lys He Glu Glu Leu Glu Asp Ala Lys Val Thr Ala Glu Asn Glu He

85 90 95

Lys Ser He Gin Asp Leu Met Gin Asp Tyr Lys Arg Ser Leu Glu Thr

100 105 110

Asn Thr He Pro Asn His Leu Asn Glu Glu Val Ser Asn Glu Glu Ala

115 120 125

Leu Asn Lys Glu Val Ser Ser Asp Glu Ser Pro Lys Glu Val Gin Leu

130 135 140

Thr Thr Asp Asn Asn Ala Lys Glu His Asp Lys Glu Lys Glu His Val 145 150 155 160

(2) INFORMATION FOR SEQ ID NO: 756:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 80 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...80

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 756 :

Met Leu Arg He Leu He Pro Leu Leu He He Val Trp Val Leu Trp

1 5 10 15

Arg Leu Phe Leu Arg Gin Lys Pro His Lys Asp Asp His Arg Asp Asn

20 25 30

His Ser Tyr Thr Gin Gin Thr Pro Lys Glu Leu Glu Asp His Met He

35 40 45

Val Cys Ser Lys Cys Gin Thr Tyr Val Ser Ser Lys Asp Ala He Tyr

50 55 60

Ser Gly Ala Val Ala Tyr Cys Ser Glu Thr Cys Leu Lys Asp Lys Gly 65 70 75 80

(2) INFORMATION FOR SEQ ID NO: 757:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 214 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...214

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 757:

Leu Asp Gly Leu Lys Lys Glu Arg Gin Gly Phe Tyr Lys Gin Val His

1 5 10 15

Tyr Leu Arg He Leu He Leu Ser Met Ser Phe Leu Asn He Leu Asn

20 25 30

Ala Glu Asn Leu Ser Tyr Met Ser Ser Ser Tyr Gin He Gly Thr Val

35 40 45

Phe Met Arg Pro Leu Asn Thr Asn Lys Leu Leu Gin Gly Ala Ser He

50 55 60

Leu Gin Gly Tyr Glu Val Asn Pro Lys Asn Asp Trp Ala Tyr Ser Arg 65 70 75 80

Tyr Tyr Phe Phe He Asp Tyr Gly Asn Val Leu Phe Asn Asn Asp Ser

85 90 95

Thr Leu Gin Ala Asn Met Phe Thr Tyr Gly Val Gly Gly Asp Phe Met

100 105 110

Val Ala Tyr Ala Lys Asn Pro He Asn Arg Trp Ala Phe Phe Phe Gly

115 120 125

Leu Gin Leu Ala Ala Asn Thr Trp He Leu Asn Asn Lys Val Lys Asp

130 135 140

Leu Val Val Asn Thr Trp Asp Ser Leu Lys Asp Phe Asn Phe His Asn 145 150 155 160

Thr Tyr Phe Arg Ala He Gly Lys Phe Gly Val Gin Phe Arg Thr He

165 170 175

Val Leu Tyr His Lys Val Asp Val Glu He Gly Met Lys He Phe Leu

180 185 190

Thr Pro Glu Arg Arg Ser Leu Phe Glu Arg Ser Phe Leu Phe Phe Val

195 200 205

Ser His Ser Trp His Phe 210

(2) INFORMATION FOR SEQ ID NO: 758:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 111 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...111

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:758: Met Lys Pro Thr Asn Glu Pro Lys Lys Pro Phe Phe Gin Ser Pro He

1 5 10 15

Val Leu Ala Val Leu Gly Gly He Leu Leu He Phe Phe Leu Arg Ser

20 25 30

Phe Asn Ser Asp Gly Ser Phe Ser Asp Asn Phe Leu Ala Ser Ser Thr

35 40 45

Lys Asn Val Ser Tyr His Glu He He Gin Leu He Ser Asn His Glu

50 55 60

Val Gly Asn Val Ser He Gly Gin Thr Leu He Lys Ala Ser His Lys 65 70 75 80

Glu Gly Asn Asn Arg Val He Tyr He Ala Lys Arg Val Leu He Tyr

85 90 95

Leu Ser Ala Phe Val Arg Arg Glu Lys Asn Gin Leu Phe Trp Phe 100 105 110

(2) INFORMATION FOR SEQ ID NO: 759:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 207 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...207

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 759 :

Met Leu Arg Val Leu Ser Val Gly Val Val Phe He Leu Leu Gly Cys

1 5 10 15

Gin Phe Phe Asn Lys Thr Thr Leu His Leu Lys Tyr Lys Asp Tyr Pro

20 25 30

Lys Asn Ser Pro Leu Lys Thr Ala Ser Thr Leu Thr Pro Pro Lys He

35 40 45

Phe Phe Asn Ala His Phe Val Pro Pro Phe Tyr Gin Lys Glu Phe Lys

50 55 60

Lys Ala Leu Ala Gin Gin He Ala Tyr Phe Leu Lys Asp Lys Ser Ala 65 70 75 80

Leu Thr Phe Asn He Ser Gly Asn Val Phe Phe Ser Phe Glu Glu Ser

85 90 95

Pro Lys Asp Leu Lys Ala He Lys Glu Arg Leu Lys Lys Thr He Glu

100 105 110

Pro Asn Thr Asp Pro Lys Ala Val Met Arg Phe Leu Asn Leu Gin Ala

115 120 125

Ser Leu He Leu Glu Cys Val Pro Gin Thr Ala Cys Pro Phe Asp Thr

130 135 140

Leu Leu He Pro Thr Ala Leu Ser Val Pro He Asp Tyr Ala Asn Arg 145 150 155 160

Leu Gly Asp Asn Pro Ser Leu Phe Pro Gin Glu Asp Lys Ser Tyr His 165 170 175

Asn Ala Leu He Lys Ala Leu Asn Lys Ala Tyr Tyr Ser Leu Met Glu

180 185 190

Gly Leu Glu Lys Arg Leu Asn Ala He Glu Asn Ala Ala Trp Leu 195 200 205

(2) INFORMATION FOR SEQ ID NO: 760:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 175 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...175

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 760 :

Met Lys Asn Gin Val Lys Lys He Leu Gly Met Ser Val Val Ala Ala

1 5 10 15

Met Val He Val Gly Cys Ser His Ala Pro Lys Ser Gly He Ser Lys

20 25 30

Ser Asn Lys Ala Tyr Lys Glu Ala Thr Lys Gly Ala Pro Asp Trp Val

35 40 45

Val Gly Asp Leu Glu Lys Val Ala Lys Tyr Glu Lys Tyr Ser Gly Val

50 55 60

Phe Leu Gly Arg Ala Glu Asp Leu He Thr Asn Asn Asp Val Asp Tyr 65 70 75 80

Ser Thr Asn Gin Ala Thr Ala Lys Ala Arg Ala Asn Leu Ala Ala Asn

85 90 95

Leu Lys Ser Thr Leu Gin Lys Asp Leu Glu Asn Glu Lys Thr Arg Thr

100 105 110

Val Asp Ala Ser Gly Lys Arg Ser He Ser Gly Thr Asp Thr Glu Lys

115 120 125

He Ser Gin Leu Val Asp Lys Glu Leu He Ala Ser Lys Met Leu Ala

130 135 140

Arg Tyr Val Gly Lys Asp Arg Val Phe Val Leu Val Gly Leu Asp Lys 145 150 155 160

Gin He Val Asp Lys Val Arg Glu Glu Leu Gly Met Val Lys Lys 165 170 175

(2) INFORMATION FOR SEQ ID NO: 761:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 88 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein (m) HYPOTHETICAL. YES

(vi) ORIGINAL SOURCE.

(A) ORGANISM- Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1.. 88

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 761 :

Met Lys Lys He Val Val Ser Leu Cys Val Ala Leu Gly Phe Leu Ser

1 5 10 15

Ala Asp Pro Ala Gin Ala Asn Lys Ala He Ser Asp Ala Asp Leu He

20 25 30

Glu Glu He Arg Asp Leu Lys Lys He He Ser Ala Gin Asn Thr Glu

35 40 45

He Asn Gin Leu Arg Lys Val Gin Glu Val Leu Ser Gly Gin Leu Gly

50 55 60

Asp Met Arg Lys Asp He Leu Ser Thr Arg Asp Tyr Cys He Ser Leu 65 70 75 80

Arg Pro Tyr He Tyr Asn Trp Arg 85

(2) INFORMATION FOR SEQ ID NO: 762:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 257 ammo acids

(D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 257

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 762:

Leu Asn Ser Gly Ser Asn Ala Ser Leu Tyr Gly Thr Ser Ala Gly Val

1 5 10 15

Asp Ala Phe Leu Asn Gly Asn Val Glu Ala He Val Gly Gly Phe Gly

20 25 30

Ser Tyr Gly Tyr Ser Ser Phe Ser Asn Gin Ala Asn Ser Leu Asn Ser

35 40 45

Gly Ala Asn Asn Ala Asn Phe Gly Val Tyr Ser Arg Phe Phe Ala Asn

50 55 60

Gin His Glu Phe Asp Phe Glu Ala Gin Gly Ala Leu Gly Ser Asp Gin 65 70 75 80

Ser Ser Leu Asn Phe Lys Ser Thr Leu Leu Gin Asp Leu Asn Gin Ser 85 90 95 Tyr Asn Tyr Leu Ala Tyr Ser Ala Thr Ala Arg Ala Ser Tyr Gly Tyr

100 105 110

Asp Phe Ala Phe Phe Arg Asn Ala Leu Val Leu Lys Pro Ser Val Gly

115 120 125

Val Ser Tyr Asn His Leu Gly Ser Thr Asn Phe Lys Ser Asn Ser Gin

130 135 140

Ser Gin Val Ala Leu Lys Asn Gly Ala Ser Ser Gin His Leu Phe Asn 145 150 155 160

Ala Asn Ala Asn Val Glu Ala Arg Tyr Tyr Tyr Gly Asp Thr Ser Tyr

165 170 175

Phe Tyr Leu His Ala Gly Val Leu Gin Glu Phe Ala His Phe Gly Ser

180 185 190

Asn Asp Val Ala Ser Leu Asn Thr Phe Lys He Asn Ala Ala Arg Ser

195 200 205

Pro Leu Ser Thr Tyr Ala Arg Ala Met Met Gly Gly Glu Leu Gin Leu

210 215 220

Ala Lys Glu Val Phe Leu Asn Leu Gly Val Val Tyr Leu His Asn Leu 225 230 235 240

He Ser Asn Ala Ser His Phe Ala Ser Asn Leu Gly Met Arg Tyr Ser

245 250 255

Phe

(2) INFORMATION FOR SEQ ID NO: 763:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 283 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...283

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 763:

Met Phe Glu Asp Phe Tyr Arg Thr Thr Leu Ser Phe Leu Arg Ser Leu

1 5 10 15

Leu Leu Leu Leu Gly Leu Leu Leu Pro Phe Ser Leu Cys He Ala Asp

20 25 30

Glu Tyr He Ser He Ser Asp Asp Trp Asp Glu Arg Ala Arg Asn Gin

35 40 45

Trp Asp Glu Thr Ala Arg Asn His Lys Thr Tyr Tyr Phe Glu Asn Gly

50 55 60

Leu Asp His Phe Asn Gin Gly Gin Tyr Lys Gin Ala Phe Lys Asp Phe 65 70 75 80

Lys Leu Ala Gin Glu Tyr Ser He Gly Leu Gly Asn Val Tyr Leu Ala

85 90 95

Lys Met Tyr Leu Glu Gly Lys Gly Val Lys Val Asp Tyr Lys Lys Ala 100 105 110 Gin Phe Tyr Ala Gin Asn Ala He Lys Gly Tyr Gly Ser Gly Leu Leu

115 120 125

Gly Gly Ala Leu He Leu Gly Arg Met Gin Ala Glu Gly Leu Gly Met

130 135 140

Lys Lys Asp Leu Lys Gin Ala Leu Lys Thr Tyr Arg His Val Val Arg 145 150 155 160

Met Phe Ser Asn Lys Ser Ala Asn Phe Ala Asn Lys Phe Gly Ser Asn

165 170 175

Leu Ala Glu Phe Thr Ser Met Leu He Gly Ser Arg Phe He Asp Leu

180 185 190

Ser Gly Leu Ser Ala Asn Pro He Lys Phe Gly Asn Lys Phe Gly He

195 200 205

Leu Val Lys Lys Ala Leu Gin He Lys Asp Asn Thr Leu Ser Trp Glu

210 215 220

Asp He Ala Glu He Ser Ser Asn He He Leu Leu Lys Gin Gin Met 225 230 235 240

Gly Glu He Leu Tyr Arg He Gly He Ala Tyr Lys Glu Gly Leu Gly

245 250 255

Thr Arg Lys Lys Lys Asp Arg Ala Lys Lys Phe Leu Gin Lys Ser Ala

260 265 270

Glu Phe Gly Tyr Glu Lys Ala Met Glu Ala Leu 275 280

(2) INFORMATION FOR SEQ ID NO: 764:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 786 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...786

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 764 :

Leu Cys Lys He Pro Leu Ser Leu Thr Leu Met Glu Ala Arg Ser Val

1 5 10 15

Leu Thr Gin Glu He Arg Ser Phe Leu Pro Glu Thr Thr Thr Ser Leu

20 25 30

Ser Leu Thr He Leu Glu Arg Ser He Cys Cys Leu He Lys Phe Leu

35 40 45

Thr Leu Thr Ser Pro Cys Leu Thr Gin Gin Arg Pro Lys He Asn Ala

50 55 60

Thr Asn Asn Asn Val Ser Val Ser Gin Gly Asn Leu Phe He Asn Ala 65 70 75 80

Ser Cys Val Gin Gin Ser Asp Pro Thr Thr Ala Ser Ala Thr Asn Pro

85 90 95

Cys Thr Thr Ala Gin Asn Asn Ala Ser Ser Ser Asn Ala Ser Asn Asn 100 105 110 Ala Pro He Ala Leu Asn Asn Asn Asp Glu Ser Leu Val Val Thr Ala

115 120 125

Asn Gly Phe Asn Phe Ser Gly Asn He Tyr Ala Asn Gly Val Val Asp

130 135 140

Phe Ser Lys He Lys Gly Ser Ala Asn Val Lys Asn Leu Tyr Leu Tyr 145 150 155 160

Asn Asn Ala Gin Phe Gin Ala Asn Asn Leu Thr He Ser Asn Gin Ala

165 170 175

Val Leu Glu Lys Asn Ala Ser Phe Val Thr Asn Asn Leu Asn He Gin

180 185 190

Gly Ala Phe Asn Asn Asn Ala Thr Gin Lys He Glu Val Leu Gin Asn

195 200 205

Leu Val He Ala Ser Asn Ala Ser Leu Ser Thr Gly He Tyr Gly Leu

210 215 220

Glu Val Gly Gly Ala Leu Asn Asn Leu Gly Ala He His Phe Asn Leu 225 230 235 240

Glu Asn Ser Gin Thr Pro Val Asn Pro Leu He Gin Val Gly Gly He

245 250 255

He Asn Leu Asn Thr Thr Gin Thr Pro Phe Met Asn Val Ser Val Ala

260 265 270

Asn Gly Gly Thr Tyr Thr Leu Leu Lys Ser Ser Arg Tyr He Asp Tyr

275 280 285

Asn He Asn Pro Asn Ser Leu Gin Ser Tyr Leu Lys Leu Tyr Thr Leu

290 295 300

He Asn He Asn Gly Asn His He Glu Glu Lys Asn Gly Val Leu Thr 305 310 315 320

Tyr Leu Gly Gin Arg Val Leu Leu Gin Asp Lys Gly Leu Leu Leu Ser

325 330 335

Val Ala Leu Pro Asn Ser Asn Asn Ala Ser Gin Asn Asn He Leu Ser

340 345 350

Leu Ser Val Leu His Asn Gin He Lys Met Ser Tyr Gly Asn Lys Val

355 360 365

Met Asp Phe Thr Pro Pro Thr Leu Gin Asp Tyr He Val Gly He Gin

370 375 380

Gly Gin Ser Ala Leu Asn Gin He Glu Ala Val Gly Gly Asn Asn Ala 385 390 395 400

He Lys Trp Leu Ser Thr Leu Met Met Glu Thr Lys Glu Asn Pro Leu

405 410 415

Phe Ala Pro He Tyr Leu Glu Asn His Ser Leu Asn Glu He Leu Gly

420 425 430

Val Thr Lys Asp Leu Gin Asn Thr Ala Ser Leu He Ser Asn Pro Asn

435 44.0 445

Phe Arg Asn Asn Ala Thr Ser Leu Leu Glu Met Ala Ser Tyr Thr Gin

450 455 460

Gin Thr Ser Arg Leu Thr Lys Leu Ser Asp Phe Arg Ala Arg Glu Gly 465 470 475 480

Glu Ser Asn Phe Ser Glu Arg Leu Leu Glu Leu Lys Asn Lys Arg Phe

485 490 495

Ser Asp Pro Asn Pro Ser Glu Val Phe Val Lys Tyr Ser Gin Leu Ser

500 505 510

Lys His Pro Asn Asn Leu Trp He Gin Gly Val Gly Gly Ala Ser Phe

515 520 525

He Ser Gly Gly Asn Gly Thr Leu Tyr Gly Leu Asn Val Gly Tyr Asp

530 535 540

Arg Leu Val Lys Ser Val He Leu Gly Gly Tyr Val Ala Tyr Gly Tyr 545 550 555 560

Ser Gly Phe Asn Gly Asn He Met His Ser Leu Ala Asn Asn Val Asp 565 570 575

Val Gly Met Tyr Ala Arg Ala Phe Leu Lys Arg Asn Glu Phe Thr Leu

580 585 590

Ser Ala Asn Glu Thr Tyr Gly Gly Asn Ala Ser His He Asn Ser Ser

595 600 605

Asn Ser Leu Leu Ser Val Leu Asn Gin Arg Tyr Asn Tyr Asn Thr Trp

610 615 620

Thr Thr Ser Val Asn Gly Asn Tyr Gly Tyr Asp Phe Met Phe Lys Gin 625 630 635 640

Lys Ser Val Val Leu Lys Pro Gin Val Gly Leu Ser Tyr His Phe He

645 650 655

Gly Leu Ser Gly Met Lys Gly Lys Met Gin Asn Pro Ala Tyr Gin Gin

660 665 670

Phe Val Met His Ser Asn Pro Ser Asn Glu Ser Val Leu Thr Leu Asn

675 680 685

Met Gly Leu Glu Ser Arg Lys Tyr Phe Gly Lys Asn Ser Tyr Tyr Phe

690 695 700

Val Thr Ala Arg Leu Gly Arg Asp Leu Leu He Lys Ala Lys Gly Asp 705 710 715 720

Asn Val Val Arg Phe Val Gly Glu Asn Thr Leu Leu Tyr Arg Lys Gly

725 730 735

Glu He Phe Asn Thr Phe Ala Ser Val He Thr Gly Gly Glu Met His

740 745 750

Leu Trp Arg Leu Met Tyr Val Asn Ala Gly Val Gly Leu Lys Met Gly

755 760 765

Leu Gin Tyr Gin Asp Leu Asn He Thr Gly Asn Val Gly Met Arg Val

770 775 780

Ala Phe 785

(2) INFORMATION FOR SEQ ID NO: 765:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 481 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(Vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: misc_feature

(B) LOCATION 1...481

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 765 :

Met Phe Arg Lys Leu Ala Thr Ser Val Ser Leu He Ser Leu Leu He

1 5 10 15

Ser Asn Ala Leu Tyr Ala Lys Glu He Ser Glu Ala Asp Lys Val He

20 25 30

Lys Ala Thr Lys Glu Thr Lys Glu Thr Lys Lys Glu Ala Lys Arg Leu

35 40 45

Lys Lys Glu Ala Lys Gin Arg Gin Gin He Pro Asp Asn Lys Lys Pro 50 55 60

Gin Tyr Val Ser Val Asp Asp Thr Lys Thr Gin Ala Leu Phe Asp He 65 70 75 80

Tyr Asp Thr Leu Asn Val Asn Asp Lys Ser Phe Gly Asp Trp Phe Gly

85 90 95

Asn Ser Ala Leu Lys Asn Lys Thr Tyr Leu Tyr Ala Met Asp Leu Leu

100 105 110

Asp Tyr Asn Asn Tyr Leu Ser He Glu Asn Pro He He Lys Thr Arg

115 120 125

Ala Met Gly Thr Tyr Ala Asp Leu He He He Thr Gly Ser Leu Glu

130 135 140

Gin Val Asn Gly Tyr Tyr Asn He Leu Lys Ala Leu Asn Lys Arg Asn 145 150 155 160

Ala Lys Phe Val Leu Lys He Asn Asp Lys He Pro Tyr Ala Gin Ala

165 170 175

Thr Phe Leu Arg Val Pro Lys Arg Ser Asp Pro Asn Ala His Thr Leu

180 185 190

Asp Lys Gly Ala Ser He Asp Glu Ser Lys Leu Phe Glu Gin Gin Lys

195 200 205

Lys Met Tyr Phe Asn Tyr Ala Asn Asp Val He Cys Arg Pro Asn Asp

210 215 220

Glu Val Cys Ser Pro Leu Arg Asp Glu Met Val Ala Met Pro Thr Asn 225 230 235 240

Asp Ser Val Thr Gin Lys Pro Asn He He Ala Pro Tyr Ser Leu Tyr

245 250 255

Arg Leu Lys Glu Thr Asn Asn Ala Asn Glu Ala Gin Pro Ser Pro Tyr

260 265 270

Ala Thr Gin Thr Ala Pro Glu Asn Ser Lys Glu Lys Leu He Glu Glu

275 280 285

Leu He Ala Asn Ser Gin Leu He Ala Asn Glu Glu Glu Arg Glu Lys

290 295 300

Lys Leu Leu Ala Glu Lys Glu Lys Gin Glu Thr Glu Leu Ala Lys Tyr 305 310 315 320

Lys Leu Lys Asp Leu Glu Asn Gin Lys Lys Leu Lys Ala Leu Glu Ala

325 330 335

Glu Leu Lys Lys Lys Asn Thr Lys Lys Pro Arg Val Val Glu Val Pro

340 345 350

He Pro Pro Lys Thr Ser Asp Ser Asp Glu Thr Met Arg Val He Lys

355 360 365

Glu Lys Glu Asn Tyr Asn Gly Leu Leu Val Asp Lys Glu Thr Thr He

370 375 380

Lys Arg Ser Tyr Lys Gly Thr Leu He Ser Glu Asn Ser Tyr Ser Lys 385 390 395 400

Lys Thr Pro He Asn Leu Glu Asp Leu Arg Ser Leu Glu Glu Glu He

405 410 415

Lys Ser Tyr Tyr Val Lys Ser Asn Gly Leu Cys Tyr Ala Asn Gly He

420 425 430

Asn Leu Tyr Val Lys He Lys Asn Asp Pro Tyr Lys Glu Gly Met Leu

435 440 445

Cys Gly Tyr Glu Ser Val Gin Lys Leu Leu Ser Pro Leu Arg Asp Lys

450 455 460

Leu Lys Tyr Asp Lys Gin Lys Leu Gin Lys Ala Leu Leu Lys Asp Leu 465 470 475 480

Lys

(2) INFORMATION FOR SEQ ID NO: 766 (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 59 ammo acids

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME / KEY : miscjeature

( B ) LOCATION 1 . . . 59

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 766 :

Leu Leu Ser Arg Ser Met Pro Lys He Hi s Ala Val Phe Lys Ala Phe

1 5 10 15

He Pro He Pro Phe Ala Leu Phe Ala He His Phe Val Val Leu Gly

20 25 30

He Gly Ser Val Phe Asn Leu Asn Arg He Lys Asp Lys Lys Phe He

35 40 45

Leu Arg Ala Lys He Ser His He Ala Gin Ala 50 55

(2) INFORMATION FOR SEQ ID NO: 767:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 263 ammo acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...263

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 767 :

Met Arg Lys Thr He Ser Ala Leu Phe Leu Ser Ala Cys He Gly Leu

1 5 10 15

Ser Ser Val His Ala Ser Asn Ala Leu He Leu Gin Thr Asp Phe Ser

20 25 30

Leu Lys Asp Gly Ala Val Ser Ala Met Lys Gly Val Ala Phe Ser Val

35 40 45

Asp Ser Asn Leu Lys He Phe Asp Leu Thr His Glu He Pro Pro Tyr

50 55 60

Asn He Trp Glu Gly Ala Tyr Arg Leu Tyr Gin Thr Ala Ser Tyr Trp 65 70 75 80

Pro Lys Gly Ser Val Phe Val Ser Val Val Asp Pro Gly Val Gly Thr

85 90 95

Asn Arg Lys Ser Val Val Leu Lys Thr Lys Asn Gly Gin Tyr Phe Val

100 105 110

Ser Pro Asp Asn Gly Thr Leu Thr Leu Val Ala Gin Thr Leu Gly He

115 120 125

Asp Ser Val Arg Glu He Asp Glu Lys Ala Asn Arg Leu Lys Gly Ser

130 135 140

Glu Lys Ser Tyr Thr Phe His Gly Arg Asp Val Tyr Ala Tyr Thr Gly 145 150 155 160

Ala Arg Leu Ala Ser Gly Ala He Thr Phe Glu Gin Val Gly Pro Glu

165 170 175

Leu Pro He Lys Val Val Glu He Pro Tyr Gin Lys Ala Lys Ala Thr

180 185 190

Lys Gly Gly Val Lys Gly Asn He Pro He Leu Asp He Gin Tyr Gly

195 200 205

Asn Val Trp Ser Asn He Ser Asp Lys Leu Leu Asn Gin Ala Gly He

210 215 220

Lys Arg Asn Asp Thr Val Cys Val Thr He Leu Lys He Pro Arg Asn 225 230 235 240

Asn Thr Lys Gly Lys Cys Arg Met Ser Arg Ala Leu Ala Met Cys Gin

245 250 255

Lys Ala Ser Arg Trp Ser He 260

(2) INFORMATION FOR SEQ ID NO: 768:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 114 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...114

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 768 :

Met Asn He Lys Thr His Ser Ser Asn Glu Lys Glu Arg Phe Val Arg

1 5 10 15

He Glu Glu Asp Glu Lys Lys Glu Leu Phe Ala Glu Ala Thr Asn Glu

20 25 30

Asn Pro His Gly Leu Ser Leu Met Ala Leu He Gly Val Leu Val Phe

35 40 45

Gly Gly Ala Phe Leu Ala Leu Leu Val Pro Lys He Tyr Leu Ser Asn

50 55 60

Asn He Tyr Tyr He Ser Arg Lys He Asn Thr Leu Glu Asp Gin Lys 65 70 75 80

Arg Leu Leu Leu Glu Glu Gin Gin He Leu Lys Asn Glu Leu Glu Lys 85 90 95

Glu Arg Phe Lys Tyr Tyr He Glu Asn Ser Glu Asn He Gly Asp He

100 105 110

Ala Phe

(2) INFORMATION FOR SEQ ID NO: 769:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 941 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...941

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 769 :

Leu Gin His Lys Thr He Met Asp Lys He He He Gin Gly Ala Arg

1 5 10 15

Glu Asn Asn Leu Lys Asn He Phe Leu Glu He Pro Lys Asn Gin Phe

20 25 30

Val Val Phe Thr Gly Leu Ser Gly Ser Gly Lys Ser Thr Leu Ala Phe

35 40 45

Asp Thr Leu Tyr Ala Glu Gly Gin Arg Arg Tyr Leu Glu Ser Leu Ser

50 55 60

Ser Tyr Ala Arg Gin Phe Leu Asp Lys Val Gly Lys Pro Asn Val Asp 65 70 75 80

Lys He Glu Gly Leu Thr Pro Ala He Ala He Asp Gin Lys Thr Thr

85 90 95

Ser Lys Asn Pro Arg Ser Thr Val Gly Thr He Thr Glu He Tyr Asp

100 105 110

Tyr Leu Arg Leu Leu Phe Ala Arg Val Gly Glu Gin Phe Cys Pro Thr

115 120 125

Cys Leu Glu Pro He Ser Ser Met Ser Ala Ser Asp He He Ser Gin

130 135 140

He Cys His Leu Glu Glu Asn Ser Lys He He He Leu Ala Pro He 145 150 155 160

He Lys Asp Lys Lys Gly Ser Phe Asn Asp Lys Leu Glu Ser Leu Arg

165 170 175

Leu Lys Gly Tyr Val Arg Ala Phe Val Asp Gly Val Met Val Arg Leu

180 185 190

Asp Glu Glu He His Leu His Lys Thr Lys Lys His Thr He Glu Ala

195 200 205

Val Val Asp Arg Val Val He Asn Ser Glu Asn Ala Ser Arg He Ala

210 215 220

Ser Ala Val Glu Lys Ala Leu Lys Glu Ser Tyr Gly Glu Leu Glu Val 225 230 235 240

Glu He Leu Gin Asp Asn Ala Pro Ser He Arg Lys His Tyr Ser Glu 245 250 255

His Lys Ala Cys Phe Lys Cys Lys Met Ser Phe Glu Glu Leu Glu Pro

260 265 270

Leu Ser Phe Ser Phe Asn Ser Pro Lys Gly Ala Cys Glu Ser Cys Leu

275 280 285

Gly Leu Gly Thr Lys Phe Ser Leu Asp He Ser Lys He Leu Asp Pro

290 295 300

Asn Thr Pro Leu Asn Gin Gly Ala He Lys Val He Phe Gly Tyr Asn 305 310 315 320

Arg Ser Tyr Tyr Ala Gin Met Phe Glu Gly Phe Cys Thr Tyr Asn Gly

325 330 335

He Asp Ser Ala Leu Cys Phe Asn Glu Leu Asn Lys Glu Gin Gin Asp

340 345 350

Ala Leu Leu Tyr Gly Asn Gly Thr Glu He Ser Phe His Phe Lys Asn

355 360 365

Ser Pro Leu Lys Arg Pro Trp Lys Gly He He Gin He Ala Tyr Asp

370 375 380

Met Phe Lys Glu Gin Lys Asp Leu Ser Asp Tyr Met Ser Glu Lys Thr 385 390 395 400

Cys Ser Ser Cys Asn Gly His Arg Leu Lys Ala Ser Ser Leu Ser Val

405 410 415

Gin Val Ala Gly Leu Lys Met Ala Asp Phe Leu Thr Lys Pro He Glu

420 425 430

Glu Val Tyr His Phe Phe Asn Asp Pro Thr His Phe Asn Tyr Leu Asn

435 440 445

Glu Gin Glu Lys Lys He Ala Glu Pro He Leu Lys Glu He Leu Glu

450 455 460

Arg Val Phe Phe Leu Tyr Asp Val Gly Leu Gly Tyr Leu Thr Leu Gly 465 470 475 480

Arg Asp Ala Arg Thr He Ser Gly Gly Glu Ser Gin Arg He Arg He

485 490 495

Ala Ser Gin He Gly Ser Gly Leu Thr Gly Val Leu Tyr Val Leu Asp

500 505 510

Glu Pro Ser He Gly Leu His Glu Lys Asp Thr Leu Lys Leu He Asn

515 520 525

Thr Leu Arg Asn Leu Gin Lys Lys Gly Asn Thr Leu He Val Val Glu

530 535 540

His Asp Lys Glu Thr He Lys His Ala Asp Phe Val Val Asp He Gly 545 550 555 560

Pro Lys Ala Gly Arg His Gly Gly Glu Val Val Phe Ser Gly Ser Val

565 570 575

Lys Asp Leu Leu Gin Asn Asn His Ser Thr Ala Leu Tyr Leu Asn Gly

580 585 590

Thr Lys Lys He Glu Arg Pro Lys Phe Glu Pro Pro Lys Glu Lys His

595 600 605

Phe Leu Glu He Lys Asn Val Asn He Asn Asn He Lys Asn Leu Ser

610 615 620

Val Gin He Pro Leu Lys Gin Leu Val Cys He Thr Gly Val Ser Gly 625 630 635 640

Ser Gly Lys Ser Ser Leu He Leu Gin Thr Leu Leu Pro Thr Ala Gin

645 650 655

Thr Leu Leu Asn His Ala Lys Lys Asn Gin Ser Leu Asn Gly Val Glu

660 665 670

He Val Gly Leu Glu Tyr Leu Asp Lys Val He Tyr Leu Asp Gin Ala

675 680 685

Pro He Gly Lys Thr Pro Arg Ser Asn Pro Ala Thr Tyr Thr Gly Val 690 695 700 Met Asp Glu He Arg He Leu Phe Ala Glu Gin Lys Glu Ala Lys He 705 710 715 720

Leu Gly Tyr Ser Thr Ser Arg Phe Ser Phe Asn Val Lys Gly Gly Arg

725 730 735

Cys Glu Lys Cys Gin Gly Asp Gly Asp He Lys He Glu Met His Phe

740 745 750

Leu Pro Asp Val Leu Val Gin Cys Asp Ser Cys Lys Gly Ala Lys Tyr

755 760 765

Asn Pro Gin Thr Leu Glu He Lys Val Lys Gly Lys Ser He Ala Asp

770 775 780

Val Leu Asn Met Ser Val Glu Glu Ala Tyr Glu Phe Phe Ala Lys Phe 785 790 795 800

Pro Lys He Ala Val Lys Leu Lys Thr Leu He Asp Val Gly Leu Gly

805 810 815

Tyr He Thr Leu Gly Gin Asn Ala Thr Thr Leu Ser Gly Gly Glu Ala

820 825 830

Gin Arg He Lys Leu Ala Lys Glu Leu Ser Lys Lys Asp Thr Gly Lys

835 840 845

Thr Leu Tyr He Leu Asp Glu Pro Thr Thr Gly Leu His Phe Glu Asp

850 855 860

Val Asn His Leu Leu Gin Val Leu His Ser Leu Val Ala Leu Gly Asn 865 870 875 880

Ser Met Leu Val He Glu His Asn Leu Asp He He Lys Asn Ala Asp

885 890 895

Tyr He He Asp Met Gly Pro Asp Gly Gly Asp Lys Gly Gly Lys Val

900 905 910

He Ala Ser Gly Thr Pro Leu Glu Val Ala Gin Asn Cys Glu Lys Thr

915 920 925

Gin Ser Tyr Thr Gly Lys Phe Leu Ala Leu Glu Leu Lys 930 935 940

(2) INFORMATION FOR SEQ ID NO: 770:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 83 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME/ KEY : mi scjeature

( B ) LOCATION 1 . . . 83

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 770 :

Met Asn Tyr Asp Val Leu Met Gly Phe Leu Ala Leu He Leu Leu He

1 5 10 15

Leu Trp Tyr Ala Tyr Gly Leu Arg Gin Tyr Leu Lys Leu Lys Asp Lys

20 25 30

Asn Lys Arg Leu Lys Glu Lys Leu Gin Arg Cys Asn Cys Asn He Lys 35 40 45 He Pro Ser He Leu Glu Met Ala His Lys Pro He He Met Asp He

50 55 60

Lys Gly Glu Leu Leu Pro His Leu Thr Glu Ser Tyr Arg Lys Ser Lys 65 70 75 80

Phe Lys Glu

(2) INFORMATION FOR SEQ ID NO: 771:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 279 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...279

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 771 :

Met Arg Val He He Lys Phe Met Leu He Ser Leu Lys Thr Phe Leu

1 5 10 15

Lys He Leu Leu Lys He Phe Leu Lys Thr Phe Gin Lys He Trp He

20 25 30

Val Cys Val Val He Trp Gly Leu Gly Cys Ser Phe Leu Asn Ala Asn

35 40 45

Ser Val Gin Leu Glu Glu Thr Leu Arg Arg Asn Pro Lys Asn Leu He

50 55 60

Trp Gin His Phe Lys Lys Lys Phe Lys Lys Ser Asn Thr He Pro Tyr 65 70 75 80

Ala Pro Asn Ser Arg Trp Lys Tyr Leu Gly Thr Ser He Gly He Leu

85 90 95

Gly Val Ser Leu Val He Gly He Val Gly Leu Tyr Leu Met Pro Glu

100 105 110

Ser Val Thr Asn Trp Asp Lys Glu Lys Phe Gly Val Lys Ser Trp Phe

115 120 125

Glu Asn Val Arg Met Gly Pro Lys Leu Asp Asn Asp Ser Phe He Phe

130 135 140

Asn Glu He Leu His Pro Tyr Phe Gly Ala Met Tyr Tyr Met Gin Pro 145 150 155 160

Arg Met Ala Gly Phe Ser Trp Met Thr Ser Ala Phe Phe Ser Phe He

165 170 175

Thr Ser Thr Leu Phe Trp Glu Tyr Gly Leu Glu Ala Phe Val Glu Val

180 185 190

Pro Ser Trp Gin Asp Leu Val He Thr Pro Leu Leu Gly Ser He Leu

195 200 205

Gly Glu Gly Phe Tyr Gin Leu Thr Arg Tyr He Gin Arg Asn Glu Gly

210 215 220

Lys Leu Phe Gly Ser Leu Phe Leu Gly Arg Leu Ala He Ala Leu Met 225 230 235 240 Asp Pro He Gly Phe He He Arg Asp Leu Gly Leu Gly Glu Ala Leu

245 250 255

Gly He Tyr Asn Lys His Glu He Arg Ser Asn Leu Ser Pro Asn Gly

260 265 270

Leu Asn Leu Thr Tyr Lys Phe 275

(2) INFORMATION FOR SEQ ID NO: 772:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 177 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 177

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 772 :

Met Lys Leu Phe Asn Pro Arg Leu He Val Phe He Phe Ala Leu Leu

1 5 10 15

Leu Gly Val Gly Phe Ser Val Pro Ser Leu Leu Glu Thr Lys Gly Pro

20 25 30

Lys He Thr Leu Gly Leu Asp Leu Arg Gly Gly Leu Asn Met Leu Leu

35 40 45

Gly Val Gin Thr Asp Glu Ala Leu Lys Asn Lys Tyr Leu Ser Leu Ala

50 55 60

Ser Ala Leu Glu Tyr Asn Ala Lys Lys Gin Asn He Leu Leu Lys Asp 65 70 75 80

He Lys Ser Ser Leu Glu Gly He Ser Phe Glu Leu Leu Asp Glu Asp

85 90 95

Glu Ala Lys Lys Leu Asp Ala Leu Leu Leu Glu Leu Gin Gly His Ser

100 105 110

Gin Phe Glu He Lys Lys Glu Ala Glu Phe Tyr Ser Val Lys Leu Thr

115 120 125

Pro Leu Glu Gin Glu Glu Leu Arg Lys Asn Thr He Leu Gin Val He

130 135 140

Gly He He Arg Asn Arg Leu Asp Arg Phe Gly Leu Ala Glu Pro Val 145 150 155 160

Val He Gin Gin Gly Arg Val Glu Phe Arg Cys Asn Cys Pro Ala Leu

165 170 175

Arg

(2) INFORMATION FOR SEQ ID NO: 773:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 436 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(in) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...436

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 773:

Met Met Lys Phe Phe Leu Leu Lys Lys Phe Ser Glu Phe Leu Asn Thr

1 5 10 15

Gin Thr His Phe Asn Leu Lys Arg Leu Asn Ala Ser Ser Phe Leu Leu

20 25 30

Glu Thr Phe Ser Lys Glu Lys His Ala Phe Val Val Asp Leu Ser Ala

35 40 45

Pro Tyr He Gly Leu Ser Lys Lys Pro Pro Glu Ser Val Leu Lys Asn

50 55 60

Thr Leu Ala Leu Asp Phe Cys Leu Asn Lys Phe Thr Lys Asn Ala Lys 65 70 75 80

He Leu Gin Ala Asn Val He Asp Asn Asp Arg He Leu Glu He Lys

85 90 95

Gly Ala Lys Asp Leu Ala Tyr Lys Ser Glu Thr Phe He Leu Arg Leu

100 105 110

Glu Met He Pro Lys Lys Ala Asn Leu Met He Leu Asp Gin Glu Lys

115 120 125

Cys Val He Glu Ala Phe Arg Phe Asn Asp Arg Val Ala Lys Asn Asp

130 135 140

He Leu Gly Ala Leu Pro Pro Asn He Tyr Glu His Gin Glu Glu Asp 145 150 155 160

Leu Asp Phe Lys Gly Leu Leu Asp He Leu Glu Lys Asp Phe Leu Ser

165 170 175

Tyr Gin His Lys Glu Leu Glu His Lys Lys Asn Gin He He Lys Arg

180 185 190

Leu Asn Ala Gin Lys Glu Arg Leu Lys Glu Lys Leu Glu Lys Leu Glu

195 200 205

Asp Pro Lys Thr Leu Gin Leu Glu Ala Lys Glu Leu Gin Thr Gin Ala

210 215 220

Ser Leu Leu Leu Thr Tyr Gin His Leu He Asn Arg Arg Glu Asn Arg 225 230 235 240

Val He Leu Lys Asp Phe Glu Asp Lys Glu Cys Met He Glu He Asp

245 250 255

Lys Ser Met Pro Leu Asn Ala Phe He Asn Lys Lys Phe Thr Leu Ser

260 265 270

Lys Lys Lys Lys Gin Lys Ser Gin Phe Leu Tyr Leu Glu Glu Glu Asn

275 280 285

Leu Lys Glu Lys He Ala Phe Lys Glu Asn Gin He Asn Tyr Val Arg

290 295 300

Asp Ala Ala Glu Glu Ser Val Leu Glu Met Phe Met Pro Val Lys Asn 305 310 315 320

Ser Lys He Lys Arg Pro Met Asn Gly Tyr Glu Val Leu Tyr Tyr Lys 325 330 335 Asp Phe Lys He Gly Leu Gly Lys Asn Gin Lys Glu Asn He Lys Leu

340 345 350

Leu Gin Asp Ala Arg Ala Asn Asp Leu Trp Met His Val Arg Asp He

355 360 365

Pro Gly Ser His Leu He Val Phe Cys Gin Lys Asn Thr Pro Lys Asp

370 375 380

Glu Val He Met Glu Leu Ala Lys Met Leu He Lys Met Gin Lys Asp 385 390 395 400

Ala Phe Asn Gly Tyr Glu He Asp Tyr Thr Gin Arg Lys Phe Val Lys

405 410 415

He He Lys Gly Ala His Val He Tyr Ser Lys Tyr Arg Thr He Ser

420 425 430

Leu Lys Asp Thr 435

(2) INFORMATION FOR SEQ ID NO: 774:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 97 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...97

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 774 :

Met Gly Gin Thr Lys Glu He He Thr Thr Leu Leu Pro Leu Leu Val

1 5 10 15

Leu Phe Leu He Phe Tyr Phe Leu He Val Arg Pro Gin Arg Gin Gin

20 25 30

Gin Lys Lys His Lys Glu Met He Glu Gly Leu Thr Lys Gly Asp Lys

35 40 45

He Val Thr Gin Gly Gly Leu He Val Glu Val Leu Lys Ala Glu Ala

50 55 60

Asn Phe Phe Ser Val Lys Leu Asn Asp Asp Thr Thr Ala Lys Leu Ser 65 70 75 80

Lys Asn Tyr Val Ala Phe Lys Leu Asp Glu Glu Thr Thr Pro Asn Asn

85 90 95

Asn

(2) INFORMATION FOR SEQ ID NO: 775:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 206 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...206

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 775 :

Leu Lys Phe Gin He Val Ser Leu Leu Leu Ala Phe Leu Leu Ala Ser

1 5 10 15

Cys Leu Pro Pro Lys Gly His His Ser Gly Leu Val Asn Met Tyr He

20 25 30

Ala His Gin Gly Gin Ser Val Arg Thr Tyr Trp Arg Lys Val Asp Arg

35 40 45

Gly Val Val Ala Lys His Asn Glu Thr Leu Lys Glu Asn Pro Lys He

50 55 60

Lys Leu Lys Asp Pro Lys Gly Pro Leu Phe Met Leu Gly Ser Asn Arg 65 70 75 80

Phe Met Leu Leu Trp Lys Asn Arg Tyr Thr Leu Ala Lys Val Gin Ser

85 90 95

Phe Lys Leu Glu Pro Gly Phe Tyr Tyr Leu Asp Ser Phe Ser Val Glu

100 105 110

Thr Gin Lys Gly He Leu Gin Ser Ala Pro Gly Tyr Ser Tyr Thr Lys

115 120 125

Asn Gly Tyr Asp Phe Lys Asn Asn Arg Pro Phe Phe Leu Ala Phe Glu

130 135 140

Val Lys Pro Asp Ser Lys He Val Leu Pro Ser Val Glu Leu Ser Leu 145 150 155 160

He Lys Thr Pro Arg Gly Phe Leu Gly Val Phe Leu Phe Asp Asn Asn

165 170 175

Glu Lys Gly Ala Asn Thr Pro Trp He Glu Gly Ser Leu Asn Leu Lys

180 185 190

Leu Lys Asn Ala Ser Phe Lys Asp Ala Trp Glu Leu Glu Arg 195 200 205

(2) INFORMATION FOR SEQ ID NO: 776:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 533 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...533 ( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 776 :

Met Arg Lys Val He H e Met Asn Gly Tyr Leu Arg Val Lys Thr Pro

1 5 10 15

Tyr Phe Leu Ala Ser Val Val Leu Thr Phe Trp Thr Phe Asn Ser Phe

20 25 30

Met Ser Ala Lys Asp Lys His His Phe Leu Lys Lys Val Thr Thr Thr

35 40 45

Glu Gin Lys Phe Ser Ser Ser Ala Pro He Ser Trp Gin Ser Glu Glu

50 55 60

Val Arg Asn Ser Thr Ser Ser Arg Thr Val He Ser Asn Lys Glu Leu 65 70 75 80

Lys Lys Thr Gly Asn Leu Asn He Glu Asn Ala Leu Gin Asn Val Pro

85 90 95

Gly He Gin He Arg Asp Ala Thr Gly Thr Gly Val Leu Pro Lys He

100 105 110

Ser Val Arg Gly Phe Gly Gly Gly Gly Asn Gly His Ser Asn Thr Asn

115 120 125

Met He Leu Val Asn Gly He Pro He Tyr Gly Ala Pro Tyr Ser Asn

130 135 140

He Glu Leu Ala He Phe Pro Val Thr Phe Gin Ser Val Asp Arg He 145 150 155 160

Asp Val He Lys Gly Gly Thr Ser Val Gin Tyr Gly Pro Asn Thr Phe

165 170 175

Gly Gly Val Val Asn Val He Thr Lys Glu He Pro Lys Glu Trp Glu

180 185 190

Asn Gin Ala Ala Glu Arg He Thr Phe Trp Gly Arg Ser Ser Asn Gly

195 200 205

Asn Phe Val Asp Pro Lys Glu Lys Gly Lys Pro Leu Ala Gin Thr Leu

210 215 220

Gly Asn Gin Met Leu Phe Asn Thr Tyr Gly Arg Thr Ala Gly Met Leu 225 230 235 240

Gly Lys Tyr He Gly He Ser Ala Gin Gly Asn Trp He Asn Gly Gin

245 250 255

Gly Phe Arg Gin Asn Ser Pro Thr Lys Val Gin Asn Tyr Leu Leu Asp

260 265 270

Ala He Tyr Lys He Asn Ala Thr Asn Thr Phe Lys Ala Tyr Tyr Gin

275 280 285

Tyr Tyr Gin Tyr Asn Ser Tyr His Pro Gly Thr Leu Ser Ala Gin Asp

290 295 300

Tyr Ala Tyr Asn Arg Phe He Asn Glu Arg Pro Asp Asn Gin Asp Gly 305 310 315 320

Gly Arg Ala Lys Arg Phe Gly He Val Tyr Gin Asn Tyr Phe Gly Asp

325 330 335

Pro Asp Arg Lys Val Gly Gly Asp Phe Lys Phe Thr Tyr Phe Thr His

340 345 350

Asp Met Ser Arg Asp Phe Gly Phe Ser Asn Gin Tyr Gin Ser Val Tyr

355 360 365

Met Ser Gly Gin Asn Lys He Leu Pro Phe Lys Gly Lys Gly Glu He

370 375 380

Ser Ala Lys Asn Pro Asn Cys Gly Leu Tyr Ser Tyr Ser Asp Thr Asn 385 390 395 400

Ser Pro Cys Trp Gin Phe Phe Asp Asn He Arg Arg Ser Val Val Asn

405 410 415

Ala Phe Glu Pro Lys Leu Asn Leu He Val Asn Thr Gly Lys Val Lys 420 425 430 Gin Thr Phe Asn Met Gly Met Arg Phe Leu Thr Glu Asp Leu Tyr Arg

435 440 445

Arg Ser Thr Thr Arg Lys Asn Pro Ser Met Pro Asn Asn Gly Ser Gly

450 455 460

Phe Asp Ala Gly Thr Ser Leu Asn Asn Phe Asn Asn Tyr Thr Ala Val 465 470 475 480

Tyr Ala Ser Asp Glu He Asn Phe Asn Asn Gly Met Leu Thr He Thr

485 490 495

Pro Gly Leu Arg Tyr Thr Phe Leu Asn Tyr Glu Lys Lys Asp Ala Pro

500 505 510

Pro Phe Lys Val Gly Gin Thr Pro Lys Thr Thr Lys Glu Arg Tyr Asn

515 520 525

Gin Trp Asn Pro Ala 530

(2) INFORMATION FOR SEQ ID NO: 777:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 255 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 255

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 777 :

Met Lys Lys He Phe Leu Gly Met Ala Leu Ala Phe Ser Val Ser Met

1 5 10 15

Ala Glu Lys Ser Gly Ala Phe Leu Gly Gly Gly Phe Gin Tyr Ser Asn

20 25 30

Leu Glu Asn Gin Asn Thr Thr Arg Thr Pro Ser Ala Asn Asn Asn Thr

35 40 45

Pro He Asn Thr Ser Met Phe Gly Asn Asn Gin Ala Ala Pro Ala Gin

50 55 60

Glu Thr Pro Ser Val He Asn Thr Asn Asn Tyr Gly Gin Met Tyr Gly 65 70 75 80

Val Asp Ala Met Ala Gly Tyr Lys Trp Phe Phe Gly Lys Thr Lys Arg

85 90 95

Phe Gly Phe Arg Thr Tyr Gly Tyr Tyr Ser Tyr Asn His Ala Asn Leu

100 105 110

Ser Phe Val Gly Ser Lys Leu Gly He Met Asp Gly Ala Ser Gin Val

115 120 125

Asn Asn Phe Thr Tyr Gly Val Gly Phe Asp Ala Leu Tyr Asn Phe Tyr

130 135 140

Glu Ser Lys Glu Gly Tyr Asn Thr Ala Gly Leu Phe Val Gly Phe Gly 145 150 155 160

Leu Gly Gly Asp Ser Phe He Val Gin Gly Glu Ser Tyr Leu Lys Ser 165 170 175 Gin Met Gin He Cys Asn Asn Thr Ala Gly Cys Ser Ala Ser Met Asn

180 185 190

Thr Ser Tyr Phe Gin Met Pro Val Glu Phe Gly Phe Arg Ser Asn Phe

195 200 205

Ser Lys His Ser Gly He Glu Val Gly Phe Lys Leu Pro Leu Phe Thr

210 215 220

Asn Gin Phe Tyr Lys Glu Arg Gly Val Asp Gly Ser Val Asp Val Phe 225 230 235 240

Tyr Lys Arg Asn Phe Ser He Tyr Phe Asn Tyr Met He Asn Leu 245 250 255

(2) INFORMATION FOR SEQ ID NO: 778:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 333 ammo acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 333

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 778 :

Met Leu He Ala Arg Phe Lys Lys Ala Leu He Ser Tyr Ser Leu Gly

1 5 10 15

Val Leu Leu Val Ser Ser Leu Leu Gly Val Ala Asn Ala Ser Asn Gin

20 25 30

Glu He Gin Val Lys Asp Tyr Phe Gly Glu Gin Thr He Lys Leu Pro

35 40 45

Val Ser Lys He He Tyr Leu Gly Ser Phe Ala Glu Val Pro Ala Met

50 55 60

Phe Asn Thr Trp Asp Arg Val Val Gly He Ser Asp Tyr Ala Phe Lys 65 70 75 80

Ser Asp He Val Lys Ala Thr Leu Lys Asp Pro Glu Arg He Lys Pro

85 90 95

Met Ser Ser Asp His Val Ala Ala Leu Asn Val Glu Leu Leu Lys Lys

100 105 110

Leu Ser Pro Asp Leu Val Val Thr Phe Val Gly Asn Pro Lys Ala Val

115 120 125

Glu His Ala Lys Lys Phe Gly He Ser Phe Leu Ser Phe Gin Glu Lys

130 135 140

Thr He Val Glu Val Met Glu Asp He Asp Ala Gin Ala Lys Ala Leu 145 150 155 160

Glu Val Asp Ala Ser Lys Lys Leu Ala Lys Met Gin Glu Thr Leu Asp

165 170 175

Phe He Lys Glu Arg Leu Lys Asn Val Lys Lys Lys Lys Gly Val Glu

180 185 190

Leu Phe His Lys Ala Asn Lys He Ser Gly His Gin Ala Leu Asp Ser 195 200 205 Asp He Leu Glu Lys Gly Gly He Asp Asn Phe Gly Leu Lys Tyr Val

210 215 220

Lys Phe Gly Arg Ala Asp He Ser Val Glu Lys He Val Lys Glu Asn 225 230 235 240

Pro Glu He He Phe He Trp Trp He Ser Pro Leu Ser Pro Glu Asp

245 250 255

Val Leu Asn Asn Pro Lys Phe Ser Thr He Lys Ala He Lys Asn Lys

260 265 270

Gin Val Tyr Lys Leu Pro Thr Met Asp He Gly Gly Pro Arg Ala Pro

275 280 285

Leu He Ser Leu Phe He Ala Leu Lys Ala His Pro Glu Ala Phe Lys

290 295 300

Gly Val Asp He Asn Ala He He Lys Asp Tyr Tyr Lys Val Val Phe 305 310 315 320

Asp Leu Asn Asp Ala Glu Val Glu Pro Phe Leu Trp His 325 330

(2) INFORMATION FOR SEQ ID NO: 779:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 54 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...54

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 779 :

Met Lys Lys Gin He Leu Thr Gly Val Leu Leu Ser Val Leu Ala Val

1 5 10 15

Ser Ser Ala Tyr Ala His Lys Asp Lys Lys Asp Ala Lys Lys Pro Glu

20 25 30

Leu Ser Ser Gin Leu Val Ala His Lys Asp Lys Lys Asp Ala Lys Lys

35 40 45

Pro Lys Asn Ser Val Ala 50

(2) INFORMATION FOR SEQ ID NO: 780:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 142 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES (vi ) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...142

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 780 :

Met Tyr Lys Leu Gly He Phe Leu Leu Ala Thr Leu Leu Ser Ala Asn

1 5 10 15

Thr Gin Lys Val Ser Asp He Ala Lys Asp He Gin His Lys Glu Thr

20 25 30

Leu Leu Lys Lys Thr His Glu Glu Lys Asn Gin Leu Asn Ser Arg Leu

35 40 45

Ser Ser Leu Gly Glu Ala He Arg Ser Lys Glu Leu Gin Lys Val Glu

50 55 60

He Glu Arg Gin Met Val Ala Leu Lys Lys Ser Leu Glu Lys Asn Arg 65 70 75 80

Asn Glu Ser Leu Val Gin Glu Lys Val Leu Thr Asn Tyr Arg Lys Ser

85 90 95

Leu Asp His Leu Gin Lys Gin Arg Ser Phe Leu Gin Lys Arg Val Phe

100 105 110

Asp Thr Leu Leu Glu Asp Phe Leu Phe Ser Gin Ala Leu Lys Gly Gin

115 120 125

Asn Leu Ala Ser Ser Asn Asp Val He Leu Leu Ser Gly Val 130 135 140

(2) INFORMATION FOR SEQ ID NO: 781:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 197 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...197

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 781 :

Met Asp Lys Asn Asn Asn Asn Asn Leu Arg Leu He Leu Ala He Ala

1 5 10 15

Leu Ser Phe Leu Phe He Ala Leu Tyr Ser Tyr Phe Phe Gin Glu Pro

20 25 30

Asn Lys Thr Thr Thr Glu Thr Thr Lys Gin Glu Thr Thr Asn Asn His

35 40 45

Thr Ala Thr Ser Pro Thr Ala Ser Asn Thr He Thr Gin Asp Phe Ser

50 55 60

Val Thr Gin Thr He Pro Gin Glu Ser Leu Leu Ser Thr He Ser Phe 65 70 75 80

Glu His Ala Lys He Glu He Asp Ser Leu Gly Arg He Lys Gin Val

85 90 95

Tyr Leu Lys Asp Lys Lys Tyr Leu Thr Pro Lys Glu Lys Gly Phe Leu

100 105 110

Glu His Val Ser His Leu Phe Ser Ser Lys Glu Asn Ser Gin Pro Ser

115 120 125

Leu Lys Glu Leu Pro Leu Leu Ala Ala Asp Lys Leu Lys Pro Leu Glu

130 135 140

Val Arg Phe Leu Asp Pro Thr Leu Asn Asn Lys Ala Phe Asn Thr Pro 145 150 155 160

Tyr Ser Ala Ser Lys Thr Thr Leu Gly Pro Asn Glu Gin Leu Val Leu

165 170 175

Thr Gin Asp Leu Gly Thr Leu Ser He He Lys Thr Leu Thr Phe Tyr

180 185 190

Asp Asp Leu His Tyr 195

(2) INFORMATION FOR SEQ ID NO: 782:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 259 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...259

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 782 :

Met Ala Cys Trp His Lys Arg Leu Ala Val Gly Cys Cys He Val Leu

1 5 10 15

Leu Ser Cys Val Met Ser Ala Asn Asn Val Ser He Val Arg Asp Asp

20 25 30

Pro Pro Leu Asp Pro Thr Leu Pro Ala Trp He Tyr Ser Val Ala Leu

35 40 45

Leu Lys Val Tyr Phe Ser Asp Gly Thr Tyr Lys Glu Gly Tyr Ala Thr

50 55 60

Leu Leu Glu Asn Gly Arg Tyr He Ala Ser Ser Glu Thr Leu Tyr Ser 65 70 75 80

Asn Gly Leu Tyr Pro Lys Met He Leu Ala Lys Met Gin Asp Ser Ser

85 90 95

Ala Lys Glu Leu He Cys He Ala Ser Leu His Leu Glu Ala Met Asp

100 105 110

Arg Asp Gin Gly Leu Ser Leu Leu Lys Thr Ala Asp Phe Arg Asp Asp

115 120 125

Tyr Cys His Lys Arg Glu Glu Ser Tyr Tyr His Ala Arg He Tyr Ala

130 135 140

Lys Tyr Ala Gin Thr Phe His Ser Asn Pro Tyr Thr Asn Gin Lys Thr 145 150 155 160

Pro Thr Ser Asp Leu Tyr Tyr Pro Ala Leu Asn Glu Gly Asn Ser Phe

165 170 175

Ser He Gin Thr Thr Asp He Ser Val Ala Glu Leu Leu Lys Ser Lys

180 185 190

Lys Phe Leu Ser Leu Asp Ala Ser Phe Lys Lys Gly Ser Val Leu Trp

195 200 205

Gly Gly Arg Pro Tyr Phe Ser Glu Val Gly Glu Phe Met Gly Met Ala

210 215 220

Ser Ser Thr Leu Glu Asn Gin Glu Ser Leu Val He He Pro Lys Glu 225 230 235 240

Lys He Ala Arg Phe Leu Ser Ala Leu Lys Asn Gin Asn He Phe Pro

245 250 255

Asn He Pro

(2) INFORMATION FOR SEQ ID NO: 783:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 668 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 668

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 783:

Met Lys Asn Gin His Lys Asn Pro Leu Thr Lys Ala Leu Met Lys Thr

1 5 10 15

Tyr Pro Tyr Asn His Phe Leu Phe Phe Cys Phe He Leu Gly Ala Phe

20 25 30

Leu Leu Gly Leu Leu Ser Pro Ala Tyr Ala Leu Ser He He Thr Thr

35 40 45

Lys Glu He Asp Ala Asn Leu Leu Asn Gly Ala He Glu Ser Arg Val

50 55 60

Val Leu Gly Lys Arg Val Phe Lys Val Glu Ala His Gly Phe Tyr Phe 65 70 75 80

Arg Asn Asn Ala Thr Asn Ser He Asp He Glu He Thr Ser Leu Leu

85 90 95

Arg Asp Asn Gin Ser Phe Pro Leu Thr Ser Ser Ala Lys Thr Ser Leu

100 105 110

Lys He Pro Pro Asn Ala Lys He Lys Lys Ser Thr He Leu Val Leu

115 120 125

Lys Gly Glu Asn Ala Glu Glu Val Ala Lys He Leu Gly Val Ser Lys

130 135 140

Glu Glu Tyr Gin Lys Leu Glu Asn He Ala Gin Thr Lys Ala Ala Asn 145 150 155 160

Asp Pro Met Tyr Ala Asn Thr Pro Phe Ser Asn Gly Ser Asp Ser Ser 165 170 175

Phe Tyr Asp Asn Asn Pro Asn Ser Pro Ser Asn Asn Ala He Asn Gly

180 185 190

Lys Asp Gly Ala Asn Gly Ser Asn Gly Tyr Gly Ala Asn Gly Asn Asp

195 200 205

Gly Val Asn Gly He Ser Gly Ser Asn Gly Ala Asn Gly Ser His Ser

210 215 220

Asn Asn Asn Ala He Gly Ser Gly He Asp Thr Asp Gly Val Leu Gly 225 230 235 240

Val Asp Gly Val Asn Gly Ser Ser Ser Ser Ser Gly Gly Ser Val Gly

245 250 255

Gly Tyr Glu Asn Asn Phe Thr Asn His Gly Ser Thr Asn Asn Asn Thr

260 265 270

Gly Gly Tyr Asp Asn Phe Asn Asn Gly Ser Ser Ser Gly Gly Ser Leu

275 280 285

Gly Asn Gly Gly Leu Phe Pro He Pro Phe Gly Asn Gly Asp Thr Asn

290 295 300

Asn Ser Asn Asn Ser Thr Asn Thr Thr Ser Pro Thr Asn Gly Ser Ser 305 310 315 320

Ser Asn Asn Ala Thr Asn Pro Ser Ser Gin Glu Asn Asn Tyr Ser Ser

325 330 335

Gin Tyr Cys Lys Val Pro Glu Leu Ser Pro Asn Asn Thr Met Lys Leu

340 345 350

Asp Val He Ala Lys Asp Gly Ser Cys He Ser Met Asn Ala Leu Arg

355 360 365

Asp Asp Thr Lys Cys Ala Tyr Arg Tyr Asp Phe Glu Ala Gly Lys Ala

370 375 380

He Lys Gin Thr Gin Tyr Tyr Tyr Val Asp Arg Glu Asn Lys Thr Gin 385 390 395 400

Asn He Gly Gly Cys Val Asp Leu Gin Gly Ala Gin Tyr Ala Met Gin

405 410 415

Leu Tyr Lys Asp Asp Ser Lys Cys Ala Leu Gin Thr Thr Ser Asp Lys

420 425 430

Gly Tyr Gly Met Gly Lys Thr Gin Thr Phe Gin Thr Glu He Val Phe

435 440 445

Arg Gly Met Asp Asn Leu He His Val Ala Val Pro Cys Ser Asp Tyr

450 455 460

Ala Arg Val Gin Asp Arg He Val Arg Tyr Glu Lys Asn Asp Lys Thr 465 470 475 480

Gin Thr Leu Thr Pro He Val Asp Gin Tyr Tyr Asn Asp Pro Asn Asn

485 490 495

Pro Asn Lys Gin Glu He Leu Asn Arg Gly He Ala Thr Gin Leu Ser

500 505 510

Ser Gin Tyr Gin Glu Phe Ala Cys Gly Gin Trp Glu Tyr Asn Asp Ala

515 520 525

Lys Leu Glu Ala Lys Arg Pro Thr Met Leu Lys Ser Tyr Asn Lys Leu

530 535 540

Asn Gly Glu Trp Val Glu Val Thr Pro Cys Asn Phe Glu Ala Gly He 545 550 555 560

Lys Ser Gly Ala Val Val Ser Pro Tyr Val Met Gly Val Pro Ser Ser

565 570 575

Lys Val Leu Ser Asp He Thr Thr Ser His Tyr Phe Arg He Glu Arg

580 585 590

Lys Asn Tyr Gly Glu Arg Glu Gin Cys Gin Lys Leu Tyr Gly Val Asn

595 600 605

Arg Cys Gin Pro Gin Tyr Ser He Leu He Leu Val Ser Pro He Gly 610 615 620 Ala Pro Leu Thr Lys Pro Leu Pro Pro Lys Pro Leu Asn Leu He Tyr

625 630 635 640

Ala Gin Pro Lys He Met Lys Asn Thr Pro Gin Pro He He Leu Ser

645 650 655

Pro Leu Lys Pro Pro Ser Thr Gly Leu Lys Ala Phe

660 665

(2) INFORMATION FOR SEQ ID NO: 784:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 328 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...328

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 784 :

Met Thr Tyr Lys Glu Arg Leu He Hi s Glu Lys He Leu Asn Gin Asn

1 5 10 15

Asp Lys Gly Phe Lys Thr Glu Leu Arg He Leu Ser Val Phe He Val

20 25 30

Glu Phe Leu Val Asn He Leu Gly Phe Met Leu Ala Lys Met Pro His

35 40 45

Phe Trp Phe Leu Arg Cys Val Lys Ala Leu Ala Trp Leu Met Lys Thr

50 55 60

Phe Asp Arg Arg Arg Tyr Phe Asp Ala Lys Ala Asn Leu Asp Phe Val 65 70 75 80

Phe Gly Asp Ser Lys Ser Glu Glu Glu Lys Lys Arg He He Lys Lys

85 90 95

Gly Tyr Glu Asn Phe Ala Phe He He Leu Glu Thr He Arg Val He

100 105 110

Phe He Pro Lys Asp Glu Tyr Asp Ala Arg Phe Thr Leu He Asn Glu

115 120 125

Glu Asn Val Trp Lys Ser Leu Asn Lys Glu Gly Gin Ala He Thr Leu

130 135 140

Cys Met His Phe Gly Tyr Trp Glu Ala Val Gly Thr Thr Leu Ala Gin 145 150 155 160

Tyr Tyr Glu Asn Tyr Gly Arg Gly Cys Leu Gly Arg Leu Thr Lys Phe

165 170 175

Ala Pro He Asn His Met He Met Ser Arg Arg Glu Ala Phe Gly Val

180 185 190

Arg Phe Val Asn Lys He Gly Ala Met Lys Glu Leu He Lys Met Tyr

195 200 205

Asn Gin Gly Asn Gly Leu Val Gly He Leu Val Asp Gin Asn Val Val

210 215 220

Pro Lys Asp Gly Val Val Val Lys Phe Phe Asn Lys Asp Ala Thr Thr 225 230 235 240 Thr Thr He Ala Ser He Leu Ser Arg Arg Tyr Asn He Asp He Gin

245 250 255

Pro Val Phe He Asp Phe Asn Asp Asp Tyr Ser His Tyr Thr Ala Thr

260 265 270

Tyr Tyr Pro Ser He Arg Ser Gin He Thr Asp Asn Ala Gin Asn Asp

275 280 285

He Leu Glu Cys Thr Gin Ala Gin Ala Ser Leu Cys Glu Glu Val He

290 295 300

Arg Asn His Pro Glu Ser Tyr Phe Trp Phe His Arg Arg Phe Lys Ser 305 310 315 320

Thr His Pro Glu He Tyr Gin Arg 325

(2) INFORMATION FOR SEQ ID NO: 785:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 138 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...138

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 785 :

Met Leu Tyr Leu Arg Lys Glu Asn Gly Val Arg Thr Leu He Ser Leu

1 5 10 15

Gly He Leu Leu Ser Val Leu Asn Gly Asp Asp Leu Arg Leu Tyr Ser

20 25 30

Lys Pro Leu Val Tyr Ser Ala Gly Ser Gly He He Gly He Asp He

35 40 45

Asp Lys Arg Thr Phe Tyr Lys Arg Ala Phe Ala Phe Thr Met Lys Ser

50 55 60

Leu Phe Gly Glu Asn Leu Leu Leu Phe Val Lys Leu Lys His Ser Ala 65 70 75 80

Leu Met Ser Lys His Met Lys Gly Pro Leu Glu Asn Arg His His His

85 90 95

Ser Phe Ala Lys Asn Tyr Glu Lys Ala Val Asn Gly Cys Gin Lys Tyr

100 105 110

Val His He Lys Leu Pro Glu Gly Ala Pro Ser Asn Phe Gin Ser Gly

115 120 125

Ser Tyr Met Ala Thr Met Val Met Arg Phe 130 135

(2) INFORMATION FOR SEQ ID NO: 786:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 328 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL : YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...328

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:786:

Met Arg Lys Val Leu Tyr Ala Leu Met Gly Phe Leu Leu Val Phe Ser

1 5 10 15

Ala Leu Lys Ala Asp Asp Phe Leu Glu Glu Ala Asn Glu Thr Ala Pro

20 25 30

Ala Asn Leu Asn His Pro Met Gin Asp Leu Asn Ala He Gin Gly Ser

35 40 45

Phe Phe Asp Lys Asn Arg Ser Lys Met Ser Asn Thr Leu Asn He Asp

50 55 60

Tyr Phe Gin Gly Gin Thr Tyr Lys He Arg Leu Arg Tyr Ala Met Ala 65 70 75 80

Thr Leu Leu Phe Phe Ser Lys Pro He Ser Asp Phe Val Leu Gly Asp

85 90 95

Lys Val Gly Phe Asp Ala Lys He Leu Glu Ser Asn Asp Arg He Leu

100 105 110

Leu He Lys Pro Leu Gin He Gly Val Asp Ser Asn He Ser Val He

115 120 125

Asp Ser Glu Gly Lys He Phe Ser Phe Tyr Val Phe Ser Thr Thr Phe

130 135 140

Thr Ser Ser Lys His Pro Asn Leu Gin Val Phe He Glu Asp Lys Asn 145 150 155 160

Tyr Tyr Thr Asn Ala Phe He Lys Pro Gin Lys Glu Asn Gin Glu Asn

165 170 175

Met Ser Glu Asn Ala Pro Lys Asp Ala Gin Lys Asn Asn Lys Pro Leu

180 185 190

Lys Glu Glu Lys Glu Glu Thr Lys Glu Lys Glu Glu Glu Thr He He

195 200 205

He Gly Asp Asn Thr Asn Ala Met Lys He He Lys Lys Asp He Gin

210 215 220

Lys Gly Tyr Lys Ala Leu Lys Ser Ser Gin Arg Lys Trp Tyr Cys Leu 225 230 235 240

Trp Ala Cys Ser Lys Lys Ser Lys Leu Ser Leu Met Pro Lys Glu He

245 250 255

Phe Asn Asp Lys Gin Phe Thr Tyr Phe Lys Phe Asp Lys Arg Leu Ala

260 265 270

Leu Ser Lys Phe Pro Val He Tyr Lys Val Val Asp Gly Tyr Asp Asn

275 280 285

Pro Val Asn Thr Arg He Val Gly Asp Tyr He He Ala Glu Asp Val

290 295 300

Ser Thr Lys Trp Thr Leu Arg Leu Gly Lys Asp Tyr Leu Cys He Arg 305 310 315 320

Phe Val Lys Arg Arg Lys Gly Glu 325 (2) INFORMATION FOR SEQ ID NO: 787:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 335 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 335

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 7 87 :

Val Met Phe His Lys Ala Leu He Thr Phe He Val Leu Trp Phe Phe

1 5 10 15

Leu Asn Gly Leu Gly Ala Tyr Asp Phe Lys His Cys Gin Ala Phe Phe

20 25 30

Lys Lys Ala Ser Leu Gin Lys Gly Gly Val Ala Leu Lys Glu Leu Pro

35 40 45

Lys Gly Val Tyr Leu Tyr Tyr Ser Lys Thr Tyr Pro Lys His Ala Lys

50 55 60

Val He Lys Ser Asp Pro Phe He Gly Leu Tyr Leu Leu Gin Ser Ala 65 70 75 80

Pro Ser Glu Tyr Val Tyr Thr Leu Arg Asp Leu Asp Lys Asp Ala Leu

85 90 95

He Arg Pro Met Ala Ser He Gly Ala Asn Gin Ala Thr Glu Ala Arg

100 105 110

Leu Leu Val Gly Gin Lys Gly Tyr Asp Arg Tyr Ala Gin He Ser Gin

115 120 125

Lys Thr Gin Lys Asn Gly Val He Ser Asn He Cys Tyr Gin Met Leu

130 135 140

Gly Leu Gly Val Gly Gly Asn Gly Phe He Glu Thr Lys Phe He Lys 145 150 155 160

Arg Phe Leu Asn Gin Gin Glu Pro Tyr Tyr Gly Asp He Gly Val Arg

165 170 175

Leu Glu Glu Arg His Lys Arg Leu Val Val Ala Gin Phe Asp Pro Phe

180 185 190

Phe Pro Lys Asn Pro Phe Leu Lys Asn Asp Glu He Leu Ala He Asn

195 200 205

Asp Tyr Lys He His Ser Leu Ala Glu Phe Glu Trp Val Val Ser Asn

210 215 220

Leu Ser Tyr Gin Ser Leu Ala Lys Val Lys He Lys Arg Asn His Gin 225 230 235 240

He Lys Glu Val Thr Leu Lys Val Asn Lys Arg Tyr Gly Gly Phe Leu

245 250 255

Leu Lys Asp Thr Phe Leu Glu Arg Tyr Gly He Ala Leu Asp Glu Arg

260 265 270

Phe He He Thr Lys He Gly Ala His Leu Pro Lys Gly Leu Asp Phe 275 280 285 Leu Lys Leu Gly Asp Arg He Leu Trp Val Asn His Arg Ser Val Ser

290 295 300

Phe Asn Pro Lys Ala Leu Arg Glu Ala Leu Ser Thr Pro Lys He Glu 305 310 315 320

Leu Leu Val Trp Arg Gin Gly Phe Glu Phe Tyr He Lys Val Arg 325 330 335

(2) INFORMATION FOR SEQ ID NO: 788:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 250 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 250

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 788:

Met Leu Gly Ser Val Lys Lys Thr Leu Phe Gly Val Leu Cys Leu Gly

1 5 10 15

Ala Leu Cys Leu Arg Gly Leu Met Ala Glu Pro Asp Ala Lys Glu Leu

20 25 30

Val Ser Leu Gly He Glu Ser Val Lys Lys Gin Asp Phe Ala Gin Ala

35 40 45

Lys Ala His Phe Glu Lys Ala Cys Glu Leu Lys Glu Gly Phe Gly Cys

50 55 60

Val Phe Leu Gly Ala Phe Tyr Glu Glu Gly Lys Gly Val Gly Lys Asp 65 70 75 80

Leu Lys Lys Ala He Gin Phe Tyr Thr Lys Gly Cys Glu Leu Asn Asp

85 90 95

Gly Tyr Gly Cys Arg Leu Leu Gly Asn Leu Tyr Tyr Asn Gly Gin Gly

100 105 110

Val Ser Lys Asp Ala Lys Lys Ala Ser Gin Tyr Tyr Ser Lys Ser Cys

115 120 125

Glu Leu Asn His Ala Glu Gly Cys Thr Val Leu Gly Ser Leu His His

130 135 140

Tyr Gly Val Gly Thr Pro Lys Asp Leu Arg Lys Ala Leu Asp Leu Tyr 145 150 155 160

Glu Lys Ala Cys Asp Leu Lys Asp Ser Pro Gly Cys He Asn Ala Gly

165 170 175

Tyr Met Tyr Gly Val Ala Lys Asn Phe Lys Glu Ala He Val Arg Tyr

180 185 190

Ser Lys Ala Cys Glu Leu Lys Asp Gly Arg Gly Cys Tyr Asn Leu Gly

195 200 205

Val Met Gin Tyr Asn Ala Gin Gly Thr Ala Lys Asp Glu Lys Gin Ala

210 215 220

Val Glu Asn Phe Lys Lys Gly Cys Lys Ser Ser Val Lys Glu Ala Cys 225 230 235 240 sp Ala Leu Lys Glu Leu Lys He Glu Leu 245 250

(2) INFORMATION FOR SEQ ID NO: 789:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 123 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...123

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 789 :

Met Arg Leu Leu He Ala Leu Val Leu Phe Leu Trp Trp Leu Asn Leu

1 5 10 15

Gly Ala Lys Glu Ala Asp Phe He Ser Asp Trp Glu Tyr Gly Leu Ala

20 25 30

Leu Tyr Lys Asn Pro Arg Gly Val Ala Cys Ala Lys Cys His Gly He

35 40 45

Lys Gly Glu Gin Gin Glu He Thr Phe Tyr Tyr Glu Lys Gly Glu Lys

50 55 60

Lys He Leu Tyr Ala Pro Lys He Asn His Leu Asp Phe Lys Thr Phe 65 70 75 80

Lys Asp Ala Leu Ser Leu Gly Lys Gly Met Met Pro Lys Tyr Asn Leu

85 90 95

Asn Leu Glu Glu He Gin Ala He Tyr Leu Tyr He Thr Ser Leu Gly

100 105 110

His Lys Asp Glu Arg Lys Asp Pro Ser Lys Pro 115 120

(2) INFORMATION FOR SEQ ID NO: 790:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 180 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...180 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:790:

Met Leu Asn Lys Phe Lys Lys He Val Gly Val Gly Val Leu Val Gly

1 5 10 15

Cys Leu Gly Val Leu Gin Ala Lys Asn Ser Leu Phe Val Leu Pro Tyr

20 25 30

Glu Gin Arg Asp Ala Leu Asn Ser Leu He Ser Gly He Ser Ser Ala

35 40 45

Arg Glu Asn Val Lys He Ala He Tyr Ser Phe Thr His Arg Asp He

50 55 60

Ala Arg Ala He Lys Ser Val Ala Ser Arg Gly He Lys Val Gin He 65 70 75 80

He Tyr Asp Tyr Glu Ser Asn His Asn Asn Lys Gin Ser Thr He Gly

85 90 95

Tyr Leu Asp Lys Tyr Pro Asn Thr Lys Val Cys Leu Leu Lys Gly Leu

100 105 110

Lys Ala Lys Asn Gly Asn Tyr Tyr Gly He Met His Gin Lys Val Ala

115 120 125

He He Asp Asp Lys He Val Phe Leu Gly Ser Ala Asn Trp Ser Lys

130 135 140

Asn Ala Phe Glu Asn Asn Tyr Glu Val Leu Leu Lys Thr Asp Asp Thr 145 150 155 160

Glu Thr He Leu Lys Ala Lys Ser Tyr Tyr Gin Lys Met Leu Glu Gly

165 170 175

Cys Val Gly Phe 180

(2) INFORMATION FOR SEQ ID NO: 791:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 140 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...140

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 791:

Met Arg Arg Ser Leu Ala Phe Cys Leu Leu Ala Leu Leu Gly Leu Gin

1 5 10 15

Val Leu Gly Ala Arg Asp Phe Ser Gin Leu Lys Asn Glu Glu Leu Leu

20 25 30

Lys Leu Ala Gly Thr Leu Pro Ser Asn Glu Ala He Asp Tyr Arg Met

35 40 45

Glu Val Ser Lys Arg Leu Lys Ala Leu Ser Ala Glu Asp Ala Lys Lys

50 55 60

Phe Arg Ala Asn Phe Ser Arg He Ala Arg Lys Asn Leu Ser Lys Met 65 70 75 80

Ser Glu Glu Asp Phe Lys Lys Met Arg Glu Glu Val Arg Lys Glu Leu

85 90 95

Glu Glu Lys Thr Lys Gly Leu Ser Ala Glu Glu He Lys Ala Lys Gly

100 105 110

Leu Asn Val Ser Val Cys Ser Gly Asp Thr Arg Lys Val Trp Cys Arg

115 120 125

Ala Val Lys Lys Lys Asp Glu His Cys Ser Pro Lys 130 135 140

(2) INFORMATION FOR SEQ ID NO: 792:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 152 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...152

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 792 :

Met Lys Lys Ala Leu Lys He Leu Ser Val Gly Ala Leu Leu Phe Val

1 5 10 15

Ala Leu Asn Ala Lys Asp Phe Ser Lys Thr Ser Asp Glu Asp Leu Ala

20 25 30

Lys Met Ala Gly Val Val Ala Pro Gin Asp He Val Asp Tyr Thr Lys

35 40 45

Glu Leu Lys Lys Arg Met Glu Lys Met Pro Glu Asp Lys Arg Lys Ala

50 55 60

Phe His Lys Gin Leu His Glu Tyr Ala Thr Lys Asn Thr Asp Lys Met 65 70 75 80

Thr Val Ala Asp Phe Glu Ala Arg Gin Lys Ala He Lys Glu Ala Leu

85 90 95

Lys Lys Gly Asn Met Glu Asp Met Asp Asp Asp Phe Gly Leu Arg Ser

100 105 110

Cys Lys His Gly Lys Lys His Lys His Asp Lys His Gly Lys Lys His

115 120 125

Gly Lys Lys His Asp Lys Asp His Asp Asp Lys Asp His Asp His His

130 135 140

Asp Glu Asp His Ser Asp Lys His 145 150

(2) INFORMATION FOR SEQ ID NO: 793:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 140 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear (11] MOLECULE TYPE protein

(m) HYPOTHETICAL- YES

(vi) ORIGINAL SOURCE-

(A) ORGANISM Helicobacter pylori

(ix) FEATURE:

( A ) NAME / KEY : miscjeature

( B ) LOCATION 1 . . . 140

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 793 :

Met Leu Lys Lys Leu Leu Leu He Ser Leu Phe Leu Gly Phe Leu Arg

1 5 10 15

Ala Glu Gly Glu His Tyr Glu He He Ala Glu Leu Ser Lys Ala Phe

20 25 30

Leu Lys Ala Lys Glu Val Leu Thr Ala He Asn Lys Thr Cys He Glu

35 40 45

Thr Gly His Asp Arg Thr Gin He Arg Leu Gin Asn Asp Phe Leu Glu

50 55 60

Asn Leu Ser Gin Thr Glu Gin Gin Phe Asp Asp Tyr Phe Glu Lys Asp 65 70 75 80

Phe Lys Ser Val Gly Val Leu Lys Thr Leu Leu Lys Asp He Gin Ser

85 90 95

Leu Glu Lys Thr Ser Asn Lys Leu Val Cys Val Ala Pro Lys Asn Ala

100 105 110

Lys Asn Phe Glu He Leu Glu Gly Ala He Thr Gin He He Gly Leu

115 120 125

Glu Glu Gin Met Asn Gin Phe He Asn Gly Ala Lys 130 135 140

(2) INFORMATION FOR SEQ ID NO: 794:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 66 ammo acids

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE, protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 66

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 794:

Leu Ser Gly Glu Leu Arg Leu Ser Trp Trp Leu Val Ala Arg Cys Lys 1 5 10 15

Thr Leu Phe Val Leu Phe Cys Glu Gly Ser Ala Phe Ser Ser Leu Leu 20 25 30 He Ser Ser He Leu Phe Ser Leu Leu He Arg Ser Phe Thr Ser Leu

35 40 45

Val Thr Phe Ser Ser Ser Ser Ser Cys Ser He Phe Phe He Ser Leu

50 55 60

Leu Gly 65

(2) INFORMATION FOR SEQ ID NO: 795:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 89 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: Xaa = Unknown

(B) LOCATION 1...89

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 795 :

Leu Val Val Ser Gly Ser Leu Gin Asn He Val Arg Ser Phe Leu Arg

1 5 10 15

Arg He Ser Val Phe Phe He He Asp Phe He Asn Phe He Phe Val

20 25 30

He Asp Gin He He His Phe Phe Gly Asp Phe Phe He Phe Phe Phe

35 40 45

Met Leu Asn Leu Phe Tyr He Leu He Arg Leu He Asp Leu He Val

50 55 60

Leu Ser Gly Phe Ser Val Val Leu Val Arg Leu Gly Xaa Phe Phe Arg 65 70 75 80

Leu He Phe Ala Cys Ala Gin His Ala 85

(2) INFORMATION FOR SEQ ID NO: 796:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 118 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME / KEY : miscjeature

( B ) LOCATION 1 . . . 118 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:796:

Met Lys Lys Ser Leu Cys Leu Ser Phe Phe Leu Thr Phe Ser Asn Pro

1 5 10 15

Leu Gin Ala Leu Val He Glu Leu Leu Glu Glu He Lys Thr Ser Pro

20 25 30

His Lys Gly Thr Phe Lys Ala Lys Val Leu Asp Ser Lys Glu Pro Arg

35 40 45

Gin Val Leu Gly Val Tyr Asn He Ser Pro His Lys Lys Leu Thr Leu

50 55 60

Thr He Thr His He Ser Thr Ala He Val Tyr Gin Pro Leu Asp Glu 65 70 75 80

Lys Leu Ser Leu Glu Thr Thr Leu Ser Pro Asn Arg Pro Thr He Pro

85 90 95

Arg Asn Thr Gin He Val Phe Ser Ser Lys Glu Leu Lys Glu Pro His

100 105 110

Ser Asn Pro He Pro Ser 115

(2) INFORMATION FOR SEQ ID NO: 797:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 245 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...245

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 797 :

Leu Lys Ala Phe Gin Thr Phe Gly Val Phe Gly Thr Ser Val He Thr

1 5 10 15

Cys He Thr Ala Gin Asn Thr Gin Gly Val His Gly Val Tyr Pro Leu

20 25 30

Ser Val Glu Ser Val Lys Ala Gin He Leu Ala He Arg Asp Asp Phe

35 40 45

Ser He Lys Ala Phe Lys Met Gly Ala Leu Cys Asn Ala Gin He He

50 55 60

Glu Cys Val Ala Asn Ala Leu Glu Thr Cys Asp Phe Gly Leu Cys Val 65 70 75 80

Leu Asp Pro Val Met Val Ala Lys Asn Gly Ala Leu Leu Leu Glu Glu

85 90 95

Glu Ala He Leu Ser Leu Lys Lys Arg Leu Leu Pro Lys Thr Asn Leu

100 105 110

Leu Thr Pro Asn Leu Pro Glu Val Tyr Ala Leu Thr Gly Val Gin Ala

115 120 125

Arg Asp Asp Lys Ser Ala Ser Lys Ala Met Gly Val Leu Arg Asp Leu 130 135 140

Gly Val Lys Asn Ala Val He Lys Gly Gly His Thr Glu His Phe Gin 145 150 155 160

Gly Glu Phe Ser Asn Asp Trp Val Phe Leu Glu Asp Ala Glu Phe Thr

165 170 175

Leu Ser Ala Lys Arg Phe Asn Thr Lys Asn Thr His Gly Thr Gly Cys

180 185 190

Thr Leu Ser Ser Leu He Val Gly Leu Leu Ala Gin Gly Leu Asp Leu

195 200 205

Lys Asn Ala He Thr Lys Ala Lys Glu Leu Leu Thr He He He Gin

210 215 220

Asn Pro Leu Asn He Gly His Gly His Gly Pro Leu Asn Leu Trp Ser 225 230 235 240

He Lys Lys His Val 245

(2) INFORMATION FOR SEQ ID NO: 798:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 213 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...213

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:798:

Val Leu Glu Lys Gin Asp Lys Asp Leu Phe Leu Leu Gin Val Gly Asn

1 5 10 15

Arg He He Pro Thr Lys Ser Glu Gin Glu Leu Lys He Asn Gin Pro

20 25 30

Tyr Phe Ala Thr Met Gin Arg Asn Gin Leu Gly Asp He Val Leu Lys

35 40 45

Asn Leu Val Pro Ala Pro Lys He Leu Asp Ala Leu Asp Asp Leu Pro

50 55 60

Val He Glu Met Lys Lys Leu Lys Glu He Leu Ser Ala Lys Asp Asn 65 70 75 80

Thr Pro Leu Lys Glu Tyr Lys Glu Leu Leu Ser Glu Lys Leu He His

85 90 95

Ala Lys Ser Ser Gin Glu Phe Leu Asn Thr Ala Asn Met Leu Leu Ser

100 105 110

Leu Gin Ser Gin Val Leu Ser Phe Val Val Glu Asn Glu Arg Lys Lys

115 120 125

Ala Phe Leu Gin Met Lys Ala Lys Lys Gin Ser Val Asp Phe Tyr Ala

130 135 140

Leu Tyr Pro Asn Leu Gly Glu He Gly Gly Val He Tyr Leu Lys Glu 145 150 155 160

Lys Glu Lys Gin Leu Phe Leu Lys Thr Thr Leu Gin Arg Thr Lys Glu 165 170 175

Val Leu Lys Glu Ala Gin Asn Thr Leu Leu Gly Phe Ser Phe Val Glu

180 185 190

He Val Cys Glu Lys Thr Pro Met Leu Phe Ala Phe Glu Asp Arg Leu

195 200 205

Leu Asp Thr Leu Gly 210

(2) INFORMATION FOR SEQ ID NO: 799:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 91 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...91

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 799 :

Met Ser Asp Glu He Thr Gin Glu Asn Glu Leu Glu He Asn Ser Asn

1 5 10 15

Asn Gin Asn Gin Glu Pro Lys Glu Val Glu Lys Met Pro Leu Asn Asn

20 25 30

He Gin Lys Ala Lys Lys Leu Lys Asn His Ala Asn Leu He Val Arg

35 40 45

Arg Thr Asp Glu Leu Asp Lys Val He Asn Lys Arg Glu Ser Leu Gin

50 55 60

Arg Glu Phe Lys Arg Arg He Lys His Leu Asp Asn Lys He Glu Thr 65 70 75 80

Leu Ser Asn Asn He Glu Glu Leu Lys Arg Lys 85 90

(2) INFORMATION FOR SEQ ID NO: 800:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 172 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature ( B ) LOCATION 1 . . . 172

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 800 :

Met Lys Lys Tyr Gin Asn Lys Arg Lys Leu Gly Lys Arg He Asn Cys

1 5 10 15

Phe He Ser Asn Glu Cys Lys Asp He Leu Glu Asn Tyr Leu Lys Val

20 25 30

Lys Lys He Ser Val Thr Glu Cys He Glu Ser Leu Leu Leu Ala Leu

35 40 45

Asp Pro Ser Lys Glu Thr Leu Arg Ala Arg Asp Phe Tyr Glu Ser Leu

50 55 60

Phe Lys Val He Ser Leu Asn Gin His Val Tyr Lys Glu Leu Met Ala 65 70 75 80

Asn Gly Asn Asn He Asn Gin He Ala Lys Asn Thr Asn He Ala He

85 90 95

Lys Tyr Asn Lys Pro Phe Tyr Leu Gin Asn Leu Ala Phe Leu Glu Glu

100 105 110

He Phe Lys Val Met Asp Thr Leu Asn Lys Asn Val Glu Glu Cys Lys

115 120 125

Lys He Ser Leu Glu Leu Leu Leu Gin He Tyr Lys Glu Gin Lys Ser

130 135 140

Gin Thr Glu Phe Asn Ala He Ser Lys He Leu Asn Ala Leu Asn Glu 145 150 155 160

Lys Gin Ser Thr Thr Glu Pro Lys Lys Asp Asn Ala 165 170

(2) INFORMATION FOR SEQ ID NO: 801:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 320 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...320

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 801:

Met Asn Thr Asn Leu Lys Lys Ala Leu Phe Leu Thr Thr Leu Gly Tyr

1 5 10 15

Leu Gin Ala Asn Glu Gly Phe Leu Ala He Met Pro Asp Glu Asn Lys

20 25 30

Gin Glu Asp He Ser Gin Glu Gin Lys Leu Glu His Lys Met Glu Gin

35 40 45

Lys He Ala Pro Gin Asn Thr Leu Lys Lys Gin Gin Ser Ala Pro Leu

50 55 60

Gin Ser Ala Glu Leu Leu Gin Ser Gin Val Lys Arg Glu Val Lys Glu 65 70 75 80 Gin Lys Lys Ser Gin Lys His Leu Val Ala Met Gin Thr Lys Asn Gly

85 90 95

Phe Phe Leu Gly Ser Glu He Ala He Thr Gly Thr Ser Leu Lys Gin

100 105 110

Ser Leu Ser Leu He Ser Asn Ala Thr Asp Asp Leu Leu Thr Tyr Ser

115 120 125

Lys Thr Ser Lys Asn Ala Asn Phe Asn Met Gly Leu Leu He Gly Tyr

130 135 140

Gin His Tyr Phe Gly Ala Ser Lys Arg His Gly He Lys He Ser Ser 145 150 155 160

His Leu Tyr Gly Gly Thr Pro Ser Asp Val Ser Thr Asp He Lys He

165 170 175

Tyr Lys Ser Lys Val Ser Thr Asn Tyr Thr Pro Leu Asn Phe Gly He

180 185 190

Asp Val Lys Tyr Leu Phe Asp Phe Leu Asn Val He Lys Lys Asn Arg

195 200 205

His Thr Leu Gly Leu Ser Val Gly Phe Gly Trp Arg Met Gin Tyr Tyr

210 215 220

Phe Ala Lys He Asp Pro He Lys Thr Ser His Ser Glu Phe He Thr 225 230 235 240

Asn Lys Pro Lys Asp He Phe Asn His Gly Phe Tyr Pro Thr He Gly

245 250 255

Leu His Tyr Tyr Leu Asn His His Gin Phe Glu Val Asn Tyr Arg Phe

260 265 270

Gly Gly Ala He Asn Tyr Gin Ser Val Val Pro Ser Lys He Val Val

275 280 285

Gin Asn Gly Asn Phe Lys Gly Glu Val Leu Phe Ser Asn Phe Leu Thr

290 295 300

Lys Ala Thr Asn Ser Ser Tyr He Ala Phe Asn Tyr Ala Tyr Leu Phe 305 310 315 320

(2) INFORMATION FOR SEQ ID NO: 802:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 486 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...486

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 802 :

Leu Ala He Lys Arg Glu Lys Met Lys Asn Ser Ala Pro Leu Lys Asn

1 5 10 15

Lys Val Phe Cys Gly Leu Tyr Val Leu Ser Leu Ser Ala Ser Val Gin

20 25 30

Ala Phe Asp Tyr Lys He Glu Val Leu Ala Glu Ser Phe Ser Lys Val 35 40 45 Gly Phe Asn Lys Lys Lys He Asp He Ala Arg Gly He Tyr Pro Thr

50 55 60

Glu Thr Phe Val Thr Ala Val Gly Gin Gly Asn He Tyr Ala Asp Phe 65 70 75 80

Leu Ser Lys Ser Leu Lys Asp Gin Gly His Val Leu Glu Gly Lys Val

85 90 95

Gly Gly Thr He Gly Gly He Ala Tyr Asp Ser Thr Lys Phe Asn Gin

100 105 110

Gly Gly Ser Val He Tyr Asn Tyr He Gly Tyr Trp Asp Gly Tyr Leu

115 120 125

Gly Gly Lys Arg Ala Leu Leu Asp Gly Thr Ser He His Glu Cys Ala

130 135 140

Leu Gly Ser Asp Gly Lys Val He Asp Ser He Ala Cys Gly Asn Ala 145 150 155 160

Arg Ala Asn Lys He Arg Arg Asn Tyr Leu Met Asn Asn Ala Phe Leu

165 170 175

Glu Tyr Arg Tyr Lys Asp He Phe Ala Ala Lys Gly Gly Arg Tyr Gin

180 185 190

Ser Asn Ala Pro Tyr Met Ser Ser Tyr Thr Gin Gly Phe Glu He Ser

195 200 205

Ala Lys He Lys Asp Lys Asn Glu Gly Ser His Lys Leu Trp Trp Phe

210 215 220

Ser Ser Trp Gly Arg Ala Phe Ala Tyr Gly Glu Trp He Tyr Asp Phe 225 230 235 240

Tyr Ser Pro Arg Thr Val He Lys Asn Gly Arg Thr Leu Asn Tyr Gly

245 250 255

He His Leu Val Asp Tyr Thr Tyr Glu Arg Lys Gly Val Ser Val Ser

260 265 270

Pro Phe Phe Gin Phe Ser Pro Gly Thr Tyr Tyr Ser Pro Gly Val Ala

275 280 285

Val Gly Tyr Asp Ser Asn Pro Asn Phe Asn Gly Val Gly Phe Arg Ser

290 295 300

Glu Thr Lys Ala Tyr He Leu Leu Pro Val His Ala Pro Leu Lys Arg 305 310 315 320

Asp Thr Tyr Arg Tyr Ala Val Lys Ala Gly Thr Ala Gly Gin Ser Leu

325 330 335

Leu He Arg Gin Arg Phe Asp Tyr Asn Glu Phe Asn Phe Gly Gly Ala

340 345 350

Phe Tyr Lys Val Trp Lys Asn Ala Asn Ala Tyr He Gly Thr Thr Gly

355 360 365

Asn Pro Leu Gly He Asp Phe Trp Thr Asn Ser Val Tyr Asp He Gly

37-0 375 380

Gin Ala Leu Ser His Val Val Thr Ala Asp Ala Val Ser Gly Trp Val 385 390 395 400

Phe Gly Gly Gly Val His Lys Lys Trp Leu Trp Gly Thr Leu Trp Arg

405 410 415

Trp Thr Ser Gly Ala Leu Ala Asn Glu Ala Ser Ala Ala Val Asn Val

420 425 430

Gly Tyr Lys He Ser Lys Ser Leu Thr Ala Ser Val Lys Leu Glu Tyr

435 440 445

Leu Gly Val Met Thr His Ser Gly Phe Thr Val Gly Ser Tyr Arg Pro

450 455 460

Thr Pro Gly Ser Lys Ala Leu Tyr Ser Asp Arg Ser His Leu Met Thr 465 470 475 480

Thr Leu Ser Ala Lys Phe 485 (2) INFORMATION FOR SEQ ID NO: 803

(l) SEQUENCE CHARACTERISTICS.

(A) LENGTH. 167 ammo acids

(D) TOPOLOGY: linear

( i) MOLECULE TYPE: protein

(m) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...167

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 803 :

Val Cys He He Phe Asp Ala Asp He Lys Lys Glu Asn Gin Glu Ser

1 5 10 15

Asp Ala Gly Phe Asp Asn Lys Leu Lys His He Arg Glu Lys Phe Lys

20 25 30

Glu Lys Gly Thr Asp Phe Pro Lys Glu Gin He Phe Leu Phe Pro Asn

35 40 45

Asn Gin Asp Asp Gly Asp Leu Glu Thr Leu Leu Leu Glu He Ala Lys

50 55 60

His Asp Glu Phe Leu Lys Cys Phe Glu Gly Tyr Leu Glu Cys He Lys 65 70 75 80

Ser Lys Glu His Tyr Lys Pro He Lys Asn He Arg Lys Asn Met Leu

85 90 95

Tyr Ala Tyr Leu Glu Ala Leu Gly Leu Glu Asn Leu Thr Lys Thr Asn

100 105 110

He Asp Val Phe Asp Ser Lys Gly Lys He Lys Ser Arg Tyr Glu Glu

115 120 125

Asn Tyr Lys Lys Leu Thr Glu Glu Val He Asp Phe Ser Ser Asn Ser

130 135 140

Leu He Pro Leu Lys Asn Phe Leu Gly Gin Phe Ala Glu Asn Lys Gin 145 150 155 160

Lys Thr Asn Pro Lys He Phe 165

(2) INFORMATION FOR SEQ ID NO: 804:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 210 ammo acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori ( ix ) FEATURE :

( A ) NAME / KEY : mi s cjeature

( B ) LOCATION 1 . . . 210

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 804 :

Met Val Leu Lys Thr Lys Leu Lys He He Ser Ser Val H e Leu Ser

1 5 10 15

Thr Leu Leu Trp Val Gly Cys Ser Ser Glu Met Ala Thr Tyr Gin Asn

20 25 30

Val Asn Asp Ala Thr Lys Asn Thr Thr Ala Ser He Asn Ser Thr Asp

35 40 45

Leu Leu Leu Thr Ala Asn Ala Met Leu Asp Ser Met Phe Ser Asp Pro

50 55 60

Asn Phe Glu Gin Leu Lys Gly Lys His Leu He Glu Val Ser Asp Val 65 70 75 80

He Asn Asp Thr Thr Gin Pro Asn Leu Asp Met Asn Leu Leu Thr Thr

85 90 95

Glu He Ala Arg Gin Leu Arg Leu Arg Ser Asn Gly Arg Phe Asn He

100 105 110

Thr Arg Ala Ser Gly Gly Ser Gly He Glu Ala Asp Ser Arg Met Val

115 120 125

Lys Gin Arg Glu Lys Glu Arg Glu Ser Glu Glu Tyr Asn Gin Asp Thr

130 135 140

Thr Val Glu Lys Gly Thr Leu Lys Ala Ala Asp Leu Ser Leu Ser Gly 145 150 155 160

Lys Val Ser Ser He Ala Ala Ser He Ser Ser Ser Arg Gin Arg Leu

165 170 175

Asp Tyr Asp Phe Thr Leu Ser Leu Thr Asn Arg Lys Thr Gly Glu Glu

180 185 190

Val Trp Ser Asp Val Lys Pro He Val Lys Asn Ala Ser Asn Lys Arg

195 200 205

Met Phe 210

(2) INFORMATION FOR SEQ ID NO: 805:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 184 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A ) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 184

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 805:

Met Lys Ala Phe Leu Lys He Cys Met Val Leu He Phe Val Gly Val 1 5 10 15 Ala His Ala Lys Asn Pro Leu Thr Leu Ser Lys Glu Glu Glu Val Leu

20 25 30

Gin Asn Leu Gin Ser Phe Ser Ala His Phe Lys Gin Val Leu Lys Asn

35 40 45

Glu Lys Pro Leu Val Tyr Tyr Gly Val Leu Lys Ala Lys Ala Pro Asn

50 55 60

Trp Ala Leu Trp Val Tyr Glu Lys Pro Leu Lys Lys Glu He Tyr Met 65 70 75 80

Asn Asp Lys Glu Val Val Val Tyr Glu Pro Asn Leu Phe Gin Ala Thr

85 90 95

He Thr Pro Leu Lys Asp Lys Thr Asp Phe Phe Thr He Leu Lys Gin

100 105 110

Leu Lys Lys Gin Thr Asp Gly Ser Phe Lys Thr Thr He Asn Lys Thr

115 120 125

Thr Tyr Arg Leu Val Phe Lys Asp Gly Lys Pro Phe Ser Leu Glu Phe

130 135 140

Lys Asp Asp Met Asn Asn Leu Val Thr He Thr Phe Ser Gin Ala Glu 145 150 155 160

He Asn Pro Lys He Pro Asn Glu He Phe Val Phe Asn Pro Lys Asp

165 170 175

Glu Asn He Asp He Val Arg Gin 180

(2) INFORMATION FOR SEQ ID NO: 806:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 185 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...185

( Xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 806 :

Met Arg He Lys Ala Tyr Phe Leu Arg Phe He Ala Leu Val Phe He

1 5 10 15

Val Leu Leu Gly Phe Ser Ala Cys Lys Asn Ser Gin Lys Ser Gin Asp

20 25 30

Ser Gin Asn Asn Thr Thr Gin Gin Asp Ser Pro Lys Thr Tyr Thr Ala

35 40 45

Met Asp Leu Asn Asn Gin Glu Tyr Thr He Met Gly Asp Leu Asp Ser

50 55 60

Leu Asn He Ser Pro Asp Pro Asn Thr Pro Thr Leu Leu He Leu Ser 65 70 75 80

Ala Leu Asp Asn Ser Leu Lys Asp Tyr Ala Pro Thr Phe Asn Val Leu

85 90 95

Lys Lys Thr Phe Lys Asp Arg Leu Arg Val Leu He Leu Leu Asn Gin 100 105 110 Pro Tyr Ser Ser Asp Ala He Lys Gly Phe He Ala Pro Ser Gin Thr

115 120 125

Asp Leu Met He Leu Asn Pro Lys Asp Thr Ala Leu Phe Asp His Leu

130 135 140

Asn His Asp Ala Leu Asn His Ser Phe Asn Met Leu Leu Tyr Asp Lys 145 150 155 160

His Gin Leu He Lys Met Tyr Gin Gly He Val Pro Ala Glu Met Leu

165 170 175

Gin Phe Asp He Ser Asn Leu Lys Asp 180 185

(2) INFORMATION FOR SEQ ID NO: 807:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 363 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 363

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 807 :

Met Val Ser Thr Leu Lys Pro Leu Lys He Gly Lys His Thr He Lys

1 5 10 15

Phe Pro He Phe Gin Gly Gly Met Gly Val Gly He Ser Trp Asp Glu

20 25 30

Leu Ala Gly Asn Val Ala Lys Glu Gly Ala Leu Gly Val He Ser Ala

35 40 45

Val Gly Thr Gly Tyr Tyr Lys Asn Met Arg Phe Val Glu Arg He Val

50 55 60

Ala Lys Lys Pro Phe Glu Ala Leu Asn Phe Tyr Ser Lys Lys Ala Leu 65 70 75 80

Asn Glu He Phe Ala Asn Ala Arg Lys He Cys Gly Asn Lys Pro Leu

85 90 95

Gly Ala Asn He Leu Tyr Ala He Asn Asp Tyr Gly Arg Val Leu Arg

100 105 110

Asp Ser Cys Glu Ala Gly Ala Asn He He He Thr Gly Ala Gly Leu

115 120 125

Pro Thr Asn Met Pro Glu Phe Ala Lys Asp Phe Ser Asp Val Ala Leu

130 135 140

He Pro He He Ser Ser Ala Lys Ala Leu Lys He Leu Cys Lys Arg 145 150 155 160

Trp Ser Asp Arg Tyr Lys Arg He Pro Asp Ala Phe He Val Glu Gly

165 170 175

Pro Leu Ser Gly Gly His Gin Gly Phe Lys Tyr Glu Asp Cys Phe Lys

180 185 190

Glu Glu Phe Gin Leu Glu Asn Leu Val Pro Lys Val Val Glu Ala Ser 195 200 205 Lys Glu Trp Gly Asn He Pro He He Ala Ala Gly Gly He Trp Asp

210 215 220

Lys Lys Asp He Asp Thr Met Leu Ser Leu Gly Ala Ser Gly Val Gin 225 230 235 240

Met Ala Thr Arg Phe Leu Gly Thr Lys Glu Cys Asp Ala Lys Ala Tyr

245 250 255

Ala Asp Leu Leu Pro Thr Leu Lys Lys Glu Asp He Leu Leu He Lys

260 265 270

Ser Pro Val Gly Tyr Pro Ala Arg Ala He Asn Thr Gly Val He Lys

275 280 285

Arg He Glu Glu Gly Asn Ala Pro Lys He Ala Cys Val Ser Asn Cys

290 295 300

Val Ala Pro Cys Asn Arg Gly Glu Glu Ala Lys Lys Val Gly Tyr Cys 305 310 315 320

He Ala Asp Gly Leu Gly Arg Ser Tyr Leu Gly Asn Arg Glu Glu Gly

325 330 335

Leu Tyr Phe Thr Gly Ala Asn Gly Tyr Arg Val Asp Lys He He Ser

340 345 350

Val His Glu Leu He Lys Glu Leu Thr Glu Gly 355 360

(2) INFORMATION FOR SEQ ID NO: 808:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 363 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...363

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 808 :

Met Val Ser Thr Leu Lys Pro Leu Lys He Gly Lys Hi s Thr He Lys

1 5 10 15

Phe Pro He Phe Gin Gly Gly Met Gly Val Gly He Ser Trp Asp Glu

20 25 30

Leu Ala Gly Asn Val Ala Lys Glu Gly Ala Leu Gly Val He Ser Ala

35 40 45

Val Gly Thr Gly Tyr Tyr Lys Asn Met Arg Phe Val Glu Arg He Val

50 55 60

Ala Lys Lys Pro Phe Glu Ala Leu Asn Phe Tyr Ser Lys Lys Ala Leu 65 70 75 80

Asn Glu He Phe Ala Asn Ala Arg Lys He Cys Gly Asn Lys Pro Leu

85 90 95

Gly Ala Asn He Leu Tyr Ala He Asn Asp Tyr Gly Arg Val Leu Arg

100 105 110

Asp Ser Cys Glu Ala Gly Ala Asn He He He Thr Gly Ala Gly Leu 115 120 125 Pro Thr Asn Met Pro Glu Phe Ala Lys Asp Phe Ser Asp Val Ala Leu

130 135 140

He Pro He He Ser Ser Ala Lys Ala Leu Lys He Leu Cys Lys Arg 145 150 155 160

Trp Ser Asp Arg Tyr Lys Arg He Pro Asp Ala Phe He Val Glu Gly

165 170 175

Pro Leu Ser Gly Gly His Gin Gly Phe Lys Tyr Glu Asp Cys Phe Lys

180 185 190

Glu Glu Phe Gin Leu Glu Asn Leu Val Pro Lys Val Val Glu Ala Ser

195 200 205

Lys Glu Trp Gly Asn He Pro He He Ala Ala Gly Gly He Trp Asp

210 215 220

Lys Lys Asp He Asp Thr Met Leu Ser Leu Gly Ala Ser Gly Val Gin 225 230 235 240

Met Ala Thr Arg Phe Leu Gly Thr Lys Glu Cys Asp Ala Lys Ala Tyr

245 250 255

Ala Asp Leu Leu Pro Thr Leu Lys Lys Glu Asp He Leu Leu He Lys

260 265 270

Ser Pro Val Gly Tyr Pro Ala Arg Ala He Asn Thr Gly Val He Lys

275 280 285

Arg He Glu Glu Gly Asn Ala Pro Lys He Ala Cys Val Ser Asn Cys

290 295 300

Val Ala Pro Cys Asn Arg Gly Glu Glu Ala Lys Lys Val Gly Tyr Cys 305 310 315 320

He Ala Asp Gly Leu Gly Arg Ser Tyr Leu Gly Asn Arg Glu Glu Gly

325 330 335

Leu Tyr Phe Thr Gly Ala Asn Gly Tyr Arg Val Asp Lys He He Ser

340 345 350

Val His Glu Leu He Lys Glu Leu Thr Glu Gly 355 360

(2) INFORMATION FOR SEQ ID NO: 809:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 192 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME / KEY : miscjeature

( B ) LOCATION 1 . . . 192

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 809 :

Leu Leu Gly Arg Asn Gly Val Thr Leu Asn He Arg Gin Val Phe Trp

1 5 10 15

Trp Asp Asn Phe Asn Trp Ser He Gly Phe Tyr Asn Thr Phe Gly Asn

20 25 30

Ser Asp Ala Phe Leu Gly Ser His Thr Met Pro Arg Gly Asn Asn Thr 35 40 45 Ser Tyr He Ser Asn Glu He Ser Val Thr Thr Arg His Ala Gly Met

50 55 60

He Gly Tyr Asp Phe Trp Asp Asn Thr Ala Tyr Asp Gly Leu Ala Asp 65 70 75 80

Ala He Thr Asn Ala Asn Thr Phe Thr Phe Tyr Thr Ser Val Gly Gly

85 90 95

He His Lys Arg Phe Ala Trp His Val Phe Gly Arg Val Ser His Ala

100 105 110

Asn Lys Asn Ala Leu Gly Gin Val Gly Arg Ala Asn Glu Tyr Ser Leu

115 120 125

Gin Phe Asn Ala Ser Tyr Ala Phe Thr Glu Ser Val Leu Leu Asn Phe

130 135 140

Arg He Thr Tyr Tyr Gly Ala Arg He Asn Lys Gly Tyr Gin Ala Gly 145 150 155 160

Tyr Phe Gly Ala Pro Lys Phe Asn Asn Pro Asp Gly Asp Phe Ser Ala

165 170 175

Asn Tyr Gin Asp Arg Ser Tyr Met Met Thr Asn Leu Thr Leu Lys Phe 180 185 190

(2) INFORMATION FOR SEQ ID NO: 810:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 354 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 354

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 810:

Met Gin Gin Gin Leu Thr Tyr Leu Asn Ala Gly Asn Val Phe Phe Asn

1 5 10 15

Ala Met Asn Lys Ala Leu Glu Lys Asn Gly Thr Ala Thr Ala Asn Ser

20 25 30

Thr Ser Ser Thr Ser Gly Ala Thr Gly Ser Asp Gly Gin Thr Tyr Ser

35 40 45

Gin Gin Ala He Gin Tyr Leu Gin Gly Gin Gin Asn He Leu Asn Asn

50 55 60

Ala Ala Asn Leu Leu Lys Gin Asp Glu Leu Leu Leu Glu Ala Phe Asn 65 70 75 80

Ser Ala Val Ala Ala Asn He Gly Asn Lys Glu Phe Asn Ser Ala Ala

85 90 95

Phe Thr Gly Leu Val Gin Gly He He Asp Gin Ser Gin Leu Val Tyr

100 105 110

Asn Glu Leu Thr Lys Asn Thr He Ser Gly Ser Ala Val Asn Asn Ala

115 120 125

Gly He Asn Ser Asn Gin Ala Asn Ala Val Gin Gly Arg Ala Ser Gin 130 135 140 Leu Pro Asn Ala Leu Tyr Asn Val Gin Val Thr Leu Asp Lys He Asn 145 150 155 160

Ala Leu Asn Asn Gin Val Arg Ser Met Pro Tyr Leu Pro Gin Phe Arg

165 170 175

Ala Gly Asn Ser Arg Ala Thr Asn He Leu Asn Gly Phe Tyr Thr Lys

180 185 190

Val Gly Tyr Lys Gin Phe Phe Gly Lys Lys Arg Asn He Gly Leu Arg

195 200 205

Tyr Tyr Gly Phe Phe Ser Tyr Asn Gly Ala Ser Val Gly Phe Arg Ser

210 215 220

Thr Gin Asn Asn Val Gly Leu Tyr Thr Tyr Gly Val Gly Thr Asp Val 225 230 235 240

Leu Tyr Asn He Phe Ser Arg Ser Tyr Gin Asn Arg Ser Val Asp Met

245 250 255

Gly Phe Phe Ser Gly He Gin Leu Ala Gly Glu Thr Phe Gin Ser Thr

260 265 270

Leu Arg Asp Asp Pro Asn Val Lys Leu His Gly Lys He Asn Asn Thr

275 280 285

His Phe Gin Phe Leu Phe Asp Phe Gly Met Arg Met Asn Phe Gly Lys

290 295 300

Leu Asp Gly Lys Ser Asn Arg His Asn Gin His Thr Val Glu Phe Gly 305 310 315 320

Val Val Val Pro Thr He Tyr Asn Thr Tyr Tyr Lys Ser Ala Gly Thr

325 330 335

Thr Val Lys Tyr Phe Arg Pro Tyr Ser Val Tyr Trp Ser Tyr Gly Tyr

340 345 350

Ser Phe

(2) INFORMATION FOR SEQ ID NO: 811:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 748 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME/ KEY : mi scjeature

( B ) LOCATION 1 . . . 748

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 811 :

Met Glu Asp Phe Leu Tyr Asn Thr Leu Tyr Phe He Glu Asp Tyr Lys

1 5 10 15

Leu Val Val He Phe Ser Phe He Gly Leu He Ala Leu Phe Phe Leu

20 25 30

Tyr Lys Phe He Lys Thr Gin Lys Lys Val Phe Lys Asp Lys Ala Asn

35 40 45

Gin Pro Gin Lys Lys Lys Ser Phe Lys Glu He He He Asp Gly Leu 50 55 60 Lys Glu Arg Val Lys Thr Phe Gly Phe Trp Leu Gin Ala He Leu Leu 65 70 75 80

Leu Ser Tyr Ser Phe He Thr Ser Gly Leu Phe Phe Leu He Leu Leu

85 90 95

Gly Asn Phe Tyr Asp Asp Asn Arg Leu Pro Glu Ser Asp Asp Asp Leu

100 105 110

Phe Asp He Trp Val Tyr Ala He Gin Asp Phe Pro Ala Tyr Tyr Phe

115 120 125

Lys Ala Leu Thr Phe Ser Ser Leu Lys He Tyr Gly Phe Asn He Ser

130 135 140

Leu Val Val Tyr Ser Ser He Leu Cys Ser Tyr He Phe He Thr Phe 145 150 155 160

Phe Val Trp Phe Leu Lys Tyr Leu Thr Arg Thr Arg Asp He Gly Ala

165 170 175

Asn Lys Lys Val Asp Asp Leu Phe Gly Ser Ala Ser Trp Glu Thr Glu

180 185 190

Glu Lys Met He Lys Ala Lys Leu He Thr Pro Asn Asn Lys Lys Arg

195 200 205

Ala Phe Asp Lys Arg Glu Val He Val Gly Arg Arg Gly Leu Gly Asp

210 215 220

Phe He Ala Tyr Ala Gly Gin Ala Phe He Gly Leu He Ala Pro Thr 225 230 235 240

Arg Ser Gly Lys Gly Val Gly Phe He Met Pro Asn Met He Asn Tyr

245 250 255

Pro Gin Asn He Val Val Phe Asp Pro Lys Ala Asp Thr Met Glu Thr

260 265 270

Cys Gly Lys He Arg Glu Lys Arg Phe Asn Gin Lys Val Phe He Tyr

275 280 285

Glu Pro Phe Ser Leu Lys Thr His Arg Phe Asn Pro Phe Ala Tyr Val

290 295 300

Asp Phe Gly Asn Asp Val Val Leu Thr Glu Asp He Leu Ser Gin He 305 310 315 320

Asp Thr Arg Leu Lys Gly His Gly Met Val Ala Ser Gly Gly Asp Phe

325 330 335

Ser Thr Gin He Phe Gly Leu Ala Lys Leu Val Phe Pro Glu Arg Pro

340 345 350

Asn Glu Lys Asp Pro Phe Phe Ser Asn Gin Ala Arg Asn Leu Phe Val

355 360 365

He Asn Cys Asn He Tyr Arg Asp Leu Met Trp Thr Lys Lys Gly Leu

370 375 380

Glu Phe Val Lys Arg Lys Lys He He Met Pro Glu Thr Pro Thr Met 385 390 395 400

Phe Phe He Gly Ser Met Ala Ser Gly He Asn Leu He Asp Glu Asp

405 410 415

Thr Asn Met Glu Lys Val Val Ser Leu Met Glu Phe Phe Gly Gly Glu

420 425 430

Glu Asp Lys Ser Gly Asp Asn Leu Arg Ala Leu Ser Pro Ala Thr Arg

435 440 445

Asn Met Trp Asn Asn Phe Lys Thr Met Gly Gly Ala Lys Glu Thr Tyr

450 455 460

Ser Ser Val Gin Gly Val Tyr Thr Ser Ala Phe Ala Pro Tyr Asn Asn 465 470 475 480

Ala Met He Arg Asn Phe Thr Ser Ala Asn Asp Phe Asp Phe Arg Arg

485 490 495

Leu Arg He Asp Ala Val Ser He Gly Val He Ala Asn Pro Lys Glu

500 505 510

Ser Thr He Val Gly Pro He Leu Glu Leu Phe Phe Asn Val Met He 515 520 525

Tyr Ser Asn Leu He Leu Pro He His Asp Pro Gin Cys Lys Arg Ser

530 535 540

Cys Leu Met Leu Met Asp Glu Phe Thr Leu Cys Gly Tyr Leu Glu Thr 545 550 555 560

Phe Val Lys Ala Val Gly He Met Ala Glu Tyr Asn Met Arg Pro Ala

565 570 575

Phe Val Phe Gin Ser Lys Ala Gin Leu Glu Asn Asp Pro Pro Leu Gly

580 585 590

Tyr Gly Arg Asn Gly Ala Lys Thr He Leu Asp Asn Leu Ser Leu Asn

595 600 605

Met Tyr Tyr Gly He Asn Asn Asp Asn Tyr Tyr Glu His Phe Glu Lys

610 615 620

Leu Ser Lys Val Leu Gly Lys Tyr Thr Arg Gin Asp Val Ser Arg Ser 625 630 635 640

He Asp Asp Asn Thr Gly Lys Thr Asn Thr Ser He Ser Asn Lys Glu

645 650 655

Arg Phe Leu Met Thr Pro Asp Glu Leu Met Thr Met Gly Asp Glu Leu

660 665 670

He He Leu Glu Asn Thr Leu Lys Pro He Lys Cys His Lys Ala Leu

675 680 685

Tyr Tyr Asp Asp Pro Phe Phe Thr Asp Glu Leu He Lys Val Ser Pro

690 695 700

Ser Leu Ser Lys Lys Tyr Lys Leu Gly Lys Val Pro Asn Gin Ala Thr 705 710 715 720

Phe Tyr Asp Asp Leu Gin Ala Ala Lys Thr Arg Gly Glu Leu Ser Tyr

725 730 735

Asp Lys Ser Leu Val Pro Val Gly Ser Ser Glu Leu 740 745

(2) INFORMATION FOR SEQ ID NO: 812:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 34 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...34

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 812:

Leu Ser His Leu Phe Leu Val Lys Arg Pro Tyr Ser Arg Leu Tyr Leu

1 5 10 15

His Asn Gin Ser Asn His Lys Met Arg His His Ser He Leu Phe Val

20 25 30

Ser Phe (2) INFORMATION FOR SEQ ID NO: 813:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 110 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...110

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 813 :

Met Glu His His Lys Ala His Thr Thr He Gin Ala Leu Gin Ala Lys

1 5 10 15

Arg Lys Arg Leu Leu Thr Glu Leu Ala Glu Leu Glu Ala Glu He Lys

20 25 30

Val Ser Ser Glu Arg Arg Ser Ser Phe Asn Val Ser Leu Ser Pro Ser

35 40 45

Leu Leu Ala Glu He Glu Glu He Glu Tyr Glu Glu Lys Met Ser Lys

50 55 60

Glu Arg Arg He His His Asn Leu Leu Leu Ser Pro Ser Phe Met Ala 65 70 75 80

Lys Val Asp Glu Tyr Met Lys Glu Lys Gly Phe Pro Asn Arg Ser Leu

85 90 95

Leu Phe Glu Lys Ala Leu Glu Phe Tyr Met Leu Lys His Pro 100 105 110

(2) INFORMATION FOR SEQ ID NO: 814:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 158 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...158

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 814:

Val Met Arg Phe Phe Ser Phe Cys Tyr Phe Leu Phe Tyr Phe Leu Gly 1 5 10 15 Val Ser Leu His Ala Leu Ser Pro Leu Glu Glu Gin Glu Phe Leu He

20 25 30

Ser Tyr Arg Leu Lys He Val Asp Ser Arg Val Met Gly Glu Glu Tyr

35 40 45

Ser Val Ser Lys Pro He Val Ser Arg He Lys Thr Ala Pro Tyr Val

50 55 60

Leu Asp Tyr His Cys Ser He He Thr Arg Asn Leu Pro Asp Leu Lys 65 70 75 80

Asn Pro Leu Leu Gin He Lys Leu Glu Arg Phe Leu Leu Glu He Ala

85 90 95

Leu Lys Lys Glu Lys Glu Arg Val He Asp Cys Leu Leu Lys Ser Gin

100 105 110

Val Ala He Thr His Tyr Asp His Ser Tyr Lys Asn Gly Thr Thr Thr

115 120 125

Thr Ser He Leu Asn Leu Lys Ala Leu Ser Val Lys Ala Ser Leu Glu

130 135 140

Gly Asp Met Leu Ser Leu Asp He Phe Arg Lys Glu Glu Glu 145 150 155

(2) INFORMATION FOR SEQ ID NO: 815:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 117 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 117

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 815 :

Met Glu Leu He Lys Lys Leu Glu Lys Glu Ser Glu Val Leu Lys Lys

1 5 10 15

Asp Leu Gin Gin His Ser Asn Glu Leu Phe Lys Met Leu He He Asp

20 25 30

Asn Glu Asp Leu Phe Lys Glu Gin Phe Glu He Met Phe Lys Ala Trp

35 40 45

Val Glu He Val Lys Met Met Phe Glu Leu Thr Lys Lys Thr Lys Phe

50 55 60

Asp Gly Glu Met He Gly Tyr Thr Glu Glu Leu Leu Thr Phe Leu Val 65 70 75 80

Arg Asp Phe Phe Asn Gly He Phe Lys Ser Lys Val He Pro Lys Met

85 90 95

Pro He Phe Cys Gly Asp Val Lys Cys Glu Asp Phe Asn Ala Leu Arg

100 105 110

Ser Leu Val Tyr Leu 115

(2) INFORMATION FOR SEQ ID NO: 816: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 277 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 277

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 816 :

Leu Lys Arg Ala Leu Trp Leu He Leu Gly Leu Phe Tyr Ala Leu Asn

1 5 10 15

Ala Glu Ser Phe Lys Asp Val Leu Thr Lys Gly Asp Tyr Thr Phe Phe

20 25 30

Asn Lys Lys Val Val Ser Pro He Lys Arg Tyr Ala Asp Arg Ser Ala

35 40 45

Phe Tyr Leu Gly Leu Gly Tyr Gin Leu Gly Ser He Gin His Asn Ser

50 55 60

Ser Asn Leu Asn Leu Ser Gin Arg Phe Asn Lys Ser Gin He He Phe 65 70 75 80

Ser Asp Ser Leu Ser Pro Val Phe Lys Asn Ser Tyr Val Ser Asn Gly

85 90 95

Leu Gly Val Gin Val Gly Tyr Lys Trp Val Gly Lys His Glu Glu Thr

100 105 110

Lys Trp Phe Gly Phe Arg Trp Gly Leu Phe Tyr Asp Leu Ser Ala Ser

115 120 125

Leu Tyr Gly Ser Gin Glu Ser Gin Ser He He He Ser Thr Tyr Gly

130 135 140

Thr Tyr Met Asp Leu Leu Leu Asn Ala Tyr Asn Gly Asp Lys Phe Phe 145 150 155 160

Ala Gly Phe Asn Leu Gly He Ala Phe Ala Gly Val Tyr Asp Arg Leu

165 170 175

Ser Asp Ala Leu Leu Tyr Gin Thr Leu Leu Gin Asn Thr Phe Gly Gly

180 185 190

Lys Val Asn Leu Asn Gly Phe Gin Phe Leu Val Asp Leu Gly Val Arg

195 200 205

Leu Gly Asn Glu His Asn Gin Phe Gly Phe Gly He Lys He Pro Thr

210 215 220

Tyr Tyr Phe Asn His Tyr Tyr Ser Met Asn Asn He Ser Asn Asn Ser 225 230 235 240

Glu Asn Val Leu Lys Val Leu Arg Phe Leu Glu Tyr Gly He Asn Ser

245 250 255

Leu Leu Tyr Gin Val Asp Phe Arg Arg Asn Tyr Ser Val Tyr Phe Asn

260 265 270

Tyr Thr Tyr Ser Phe 275

(2) INFORMATION FOR SEQ ID NO: 817: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 493 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...493

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 817 :

Met Pro Ala Leu Asn Ser Ser Lys Asn Met Val Val Asn He Asn Gin

1 5 10 15

Thr Phe Thr Lys Asn Pro Thr Thr Glu Tyr Thr Tyr Pro Asp Gly Asn

20 25 30

Gly Asn Tyr Tyr Ser Gly Gly Ser Ser He Pro He Gin Leu Lys He

35 40 45

Ser Ser Val Asn Asp Ala Glu Asn Leu Leu Gin Gin Ala Ala Thr He

50 55 60

He Asn Val Leu Thr Thr Gin Asn Pro His Val Asn Gly Gly Gly Gly 65 70 75 80

Ala Trp Gly Phe Gly Gly Lys Thr Gly Asn Val Met Asp He Phe Gly

85 90 95

Asp Ser Phe Asn Ala He Asn Glu Met He Lys Asn Ala Gin Ala Val

100 105 110

Leu Glu Lys Thr Gin Gin Leu Asn Ala Asn Glu Asn Thr Gin He Thr

115 120 125

Gin Pro Asp Asn Phe Asn Pro Tyr Thr Ser Lys Asp Thr Gin Phe Ala

130 135 140

Gin Glu Met Leu Asn Arg Ala Asn Ala Gin Ala Glu He Leu Ser Leu 145 150 155 160

Ala Gin Gin Val Ala Asp Asn Phe His Ser He Gin Gly Pro He Gin

165 170 175

Gin Asp Leu Glu Glu Cys Thr Ala Gly Ser Ala Gly Val He Asn Asp

180 185 190

Asn Thr Tyr Gly Ser Gly Cys Ala Phe Val Lys Glu Thr Leu Asn Ser

195 200 205

Leu Glu Gin His Thr Ala Tyr Tyr Gly Asn Gin Val Asn Gin Asp Arg

210 215 220

Ala Leu Ser Gin Thr He Leu Asn Phe Lys Glu Ala Leu Ser Thr Leu 225 230 235 240

Gly Asn Asp Ser Lys Ala He Asn Ser Gly He Ser Asn Leu Pro Asn

245 250 255

Ala Lys Ser Leu Gin Asn Met Thr His Ala Thr Gin Asn Pro Asn Ser

260 265 270

Pro Glu Gly Leu Leu Thr Tyr Ser Leu Asp Thr Ser Lys Tyr Asn Gin

275 280 285

Leu Gin Thr Val Ala Gin Glu Leu Gly Lys Asn Pro Phe Arg Arg He 290 295 300 Gly Val He Asn Tyr Gin Asn Asn Asn Gly Ala Met Asn Gly He Gly 305 310 315 320

Val Gin Ala Gly Tyr Lys Gin Phe Phe Gly Lys Lys Arg Asn Trp Gly

325 330 335

Leu Arg Tyr Tyr Gly Phe Phe Asp Tyr Asn His Ala Tyr He Lys Ser

340 345 350

Asn Phe Phe Asn Ser Ala Ser Asp Val Trp Thr Tyr Gly Val Gly Met

355 360 365

Asp Ala Leu Tyr Asn Phe He Asn Asp Lys Asn Thr Asn Phe Leu Gly

370 375 380

Lys Asn Asn Lys Leu Ser Val Gly Leu Phe Gly Gly Phe Ala Leu Ala 385 390 395 400

Gly Thr Ser Trp Leu Asn Ser Gin Gin Val Asn Leu Thr Met Met Asn

405 410 415

Gly He Tyr Asn Ala Asn Val Ser Ala Ser Asn Phe Gin Phe Leu Phe

420 425 430

Asp Leu Gly Leu Arg Met Asn Leu Ala Arg Pro Lys Lys Lys Asp Ser

435 440 445

Asp His Ala Ala Gin His Gly Met Glu Leu Gly Val Lys He Pro Thr

450 455 460

He Asn Thr Asp Tyr Tyr Ser Phe Met Gly Ala Glu Leu Lys Tyr Arg 465 470 475 480

Arg Leu Tyr Ser Val Tyr Leu Asn Tyr Val Phe Ala Tyr 485 490

(2) INFORMATION FOR SEQ ID NO: 818:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 269 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 269

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 818:

Val Leu Asn Thr Thr Gin Lys Ser Leu Leu Val Phe Met Gly Val Phe

1 5 10 15

Phe Leu He Phe Gly Val Asp Gin Ala He Lys His Ala He Leu Glu

20 25 30

Gly Phe His Tyr Glu Ser Leu Val He Asp He Val Leu Val Phe Asn

35 40 45

Lys Gly Val Ala Phe Ser Leu Leu Ser Phe Leu Glu Gly Gly Leu Lys

50 55 60

Tyr Leu Gin He Leu Leu He Leu Gly Leu Phe He Phe Leu Met Arg 65 70 75 80

Gin Lys Glu Leu Phe Lys Ser His Ala He Glu Phe Gly Met Val Phe 85 90 95 Gly Ala Gly Val Ser Asn Val Leu Asn Arg Leu Val Ser Leu Gly Gin

100 105 110

Leu Tyr He Leu Tyr Asp Val Leu Ala He Arg Arg Glu Lys Met Lys

115 120 125

Asn Ser Ala Pro Leu Lys Asn Lys Val Phe Cys Gly Leu Tyr Val Leu

130 135 140

Ser Leu Ser Ala Ser Val Gin Ala Phe Asp Tyr Lys He Glu Val Leu 145 150 155 160

Ala Glu Ser Phe Ser Lys Val Gly Phe Asn Lys Lys Lys He Asp He

165 170 175

Ala Arg Gly He Tyr Pro Thr Glu Thr Phe Val Thr Ala Val Gly Gin

180 185 190

Gly Asn He Tyr Ala Asp Phe Leu Ser Lys Ser Leu Lys Asp Gin Gly

195 200 205

His Val Leu Glu Gly Lys Val Gly Gly Thr He Gly Gly He Ala Tyr

210 215 220

Asp Ser Thr Lys Phe Asn Gin Gly Gly Ser Val He Tyr Asn Tyr He 225 230 235 240

Gly Tyr Trp Asp Gly Tyr Leu Gly Gly Thr Lys Ala Cys Leu Met Ala

245 250 255

Gin Val Ser Met Thr Ala Arg Leu Ala Leu Met Ala Arg 260 265

(2) INFORMATION FOR SEQ ID NO: 819:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 198 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 198

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 819:

Met Leu Val Thr Lys Leu Ala Pro Asp Phe Lys Ala Pro Ala Val Leu

1 5 10 15

Gly Asn Asn Glu Val Asp Glu His Phe Glu Leu Ser Lys Asn Leu Gly

20 25 30

Lys Asn Gly Val He Leu Phe Phe Trp Pro Lys Asp Phe Thr Phe Val

35 40 45

Cys Pro Thr Glu He He Ala Phe Asp Lys Arg Val Lys Asp Phe His

50 55 60

Glu Lys Gly Phe Asn Val He Gly Val Ser He Asp Ser Glu Gin Val 65 70 75 80

His Phe Ala Trp Lys Asn Thr Pro Val Glu Lys Gly Gly He Gly Gin

85 90 95

Val Ser Phe Pro Met Val Ala Asp He Thr Lys Ser He Ser Arg Asp 100 105 110 Tyr Asp Val Leu Phe Glu Glu Ala He Ala Leu Arg Gly Ala Phe Leu

115 120 125

He Asp Lys Asn Met Lys Val Arg His Ala Val He Asn Asp Leu Pro

130 135 140

Leu Gly Arg Asn Ala Asp Glu Met Leu Arg Met Val Asp Ala Leu Leu 145 150 155 160

His Phe Glu Glu His Gly Glu Val Cys Pro Ala Gly Trp Arg Lys Gly

165 170 175

Asp Lys Gly Met Lys Ala Thr His Gin Gly Val Ala Glu Tyr Leu Lys

180 185 190

Glu Asn Ser He Lys Leu 195

(2) INFORMATION FOR SEQ ID NO: 820:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 215 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...215

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 820 :

Met Leu Lys Leu Ala Ser Lys Thr He Cys Leu Ser Leu He Ser Ser

1 5 10 15

Phe Thr Ala Val Glu Ala Phe Gin Lys His Gin Lys Asp Gly Phe Phe

20 25 30

He Glu Ala Gly Phe Glu Thr Gly Leu Leu Gin Gly Thr Gin Thr Gin

35 40 45

Glu Gin Thr He Ala Thr Thr Gin Glu Lys Pro Lys Pro Lys Pro Lys

50 55 60

Pro Lys Pro He Thr Pro Gin Ser Thr Tyr Gly Lys Tyr Tyr He Ser 65 70 75 80

Gin Ser Thr He Leu Lys Asn Ala Thr Glu Leu Phe Ala Glu Asp Asn

85 90 95

He Thr Asn Leu Thr Phe Tyr Ser Gin Asn Pro Val Tyr Val Thr Ala

100 105 110

Tyr Asn Gin Glu Ser Ala Glu Glu Ala Gly Tyr Gly Asn Asn Ser Leu

115 120 125

He Met He Gin Asn Phe Leu Pro Tyr Asn Leu Asn Asn He Glu Leu

130 135 140

Ser Tyr Thr Asp Asp Gin Gly Asn Val Val Ser Leu Gly Val He Glu 145 150 155 160

Thr He Pro Lys Gin Ser Gin He He Leu Pro Ala Ser Leu Phe Asn

165 170 175

Asp Pro Gin Leu Asn Ala Asp Gly Ser Asn Asn Ser Lys Pro Thr Pro 180 185 190 His Asp Phe Leu Met Pro Ala Arg Arg He Cys Leu Thr Ser Ser Ala

195 200 205

Arg Leu Gin Pro He Phe Lys 210 215

(2) INFORMATION FOR SEQ ID NO: 821:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 168 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...168

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 821 :

Met Leu Ser Ser Asn Asp Leu Phe Met Val Val Leu Gly Ala He Leu

1 5 10 15

Leu Val Leu Val Cys Leu Val Gly Tyr Leu Tyr Leu Lys Glu Lys Glu

20 25 30

Phe Tyr His Lys Met Arg Arg Leu Glu Lys Thr Leu Asp Glu Ser Tyr

35 40 45

Gin Glu Asn Tyr Leu Tyr Ser Lys Arg Leu Arg Glu Leu Glu Gly Arg

50 55 60

Leu Glu Gly Leu Ser Leu Glu Lys Ser Ala Lys Glu Asp Ser Ser Leu 65 70 75 80

Lys Thr Thr Leu Ser His Leu Tyr Asn Gin Leu Gin Glu He Gin Lys

85 90 95

Ser Met Asp Lys Glu Arg Asp Tyr Leu Glu Glu Lys He He Thr Leu

100 105 110

Glu Asn Lys Phe Lys Asp Met Gly His Tyr Ala Ala Ser Asp Glu Val

115 120 125

Asn Glu Lys Gin Val Leu Lys Met Tyr Gin Glu Gly Tyr Ser Val Asp

130 135 140

Ser He Ser Lys Glu Phe Lys Val Ser Lys Gly Glu Val Glu Phe He 145 150 155 160

Leu Asn Met Ala Gly Leu Lys Trp 165

(2) INFORMATION FOR SEQ ID NO: 822:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 338 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein (m) HYPOTHETICAL ^• YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM- Helicobacter pylori

(ix) FEATURE-

( A ) NAME / KEY . mi scjeature

( B ) LOCATION 1 . . . 33 8

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 822 :

Val Gly Phe Glu Tyr Ser He Ser His Ala Val Glu Hi s Asn Asn Pro

1 5 10 15

Phe Leu Asp Gin Glu Arg He Gin Ala He Ser Asn Ala Arg Gly Glu

20 25 30

Val Cys Gly Leu Asp Arg Val Lys Asn Glu He Thr Asp Met Pro Asn

35 40 45

Thr Phe Asn Tyr He Asn Asn Ala Leu Lys Asn Asn Ala Lys Leu Thr

50 55 60

Pro Thr Glu Lys Gin Ala Glu Thr Tyr Tyr Leu Gin Ser Thr Leu Gin 65 70 75 80

Asn He Glu Lys He Val Met Leu Ser Gly Gly Val Ala Ser Asn Pro

85 90 95

Lys Leu Ala Gin Ala Leu Glu Lys Met Gin Glu Pro He Thr Asn Pro

100 105 110

Leu Glu Leu Val Glu Asn Leu Lys Asn Leu Glu Leu Gin Phe Ser Gin

115 120 125

Ser Gin Asn Ser Met Leu Ser Ser Leu Ser Ser Gin He Ala Gin He

130 135 140

Ser Asn Ser Leu Asn Ala Leu Asp Pro Ser Ser Tyr Ser Lys Asn Val 145 150 155 160

Ser Ser Met Tyr Gly Val Gly Leu Ser Val Gly Tyr Lys His Phe Phe

165 170 175

Thr Lys Lys Lys Asn Gin Gly Phe Arg Tyr Tyr Leu Phe Tyr Asp Tyr

180 185 190

Gly Tyr Thr Asn Phe Gly Phe Val Gly Asn Gly Phe Asp Gly Leu Gly

195 200 205

Lys Met Asn Asn His Leu Tyr Gly Leu Gly He Asp Tyr Leu Phe Asn

210 215 220

Phe He Asp Asn Ala Gin Lys His Ser Ser Val Gly Phe Tyr Val Gly 225 230 235 240

Phe Ala Leu Ala Gly Ser Ser Trp Val Gly Ser Gly Leu Gly Met Trp

245 250 255

Val Ser Gin Met Asp Phe He Asn Asn Tyr Leu Thr Asp Tyr Arg Ala

260 265 270

Lys Met His Thr Ser Phe Phe Gin He Pro Leu Asn Phe Gly Val Arg

275 280 285

Val Asn Val Asp Arg His Asn Gly Phe Glu Met Gly Leu Lys He Pro

290 295 300

Leu Ala Val Asn Ser Phe Tyr Glu Thr His Gly Lys Gly Leu Asn Ala 305 310 315 320

Ser Leu Phe Phe Lys Arg Leu Val Met Phe Asn Val Ser Tyr Val Tyr

325 330 335

Ser Phe

(2) INFORMATION FOR SEQ ID NO: 823: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 80 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 80

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 823 :

Met Met Phe Glu Leu Thr Lys Lys Thr Lys Phe Asp Gly Glu Met He

1 5 10 15

Gly Tyr Thr Glu Glu Leu Leu Thr Phe Leu Val Arg Asp Phe Phe Asn

20 25 30

Gly He Phe Lys Ser Lys Val He Pro Lys Met Pro He Phe Cys Gly

35 40 45

Asp Val Lys Cys Glu Asp Phe Asn Ala Leu Arg Ser Leu Val Tyr Leu

50 55 60

Ser Val Leu Glu Leu Glu Glu Thr He Asn Pro Asn Lys He Pro Phe 65 70 75 80

(2) INFORMATION FOR SEQ ID NO: 824:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 200 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...200

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 824:

Val Gin Leu Leu Lys Asp Asn Lys Glu Val Val Val Leu Asp Thr Asp

1 5 10 15

Ser Gin Lys Ser Met Glu Thr Phe Ala Thr He Arg Ala Glu Lys Glu

20 25 30

Arg Pro Thr Phe Ser Leu Phe Asn Arg Ser Ser Gly Phe Ser Asp Thr

35 40 45

Leu Lys Gin Met Val Ser Lys Tyr Glu Asn He Leu He Asp Thr Lys 50 55 60

Gly Glu Tyr Ser Lys Glu Thr Gin Lys Ala Met Leu Leu Ser Asn He 65 70 75 80

Val Leu Val Pro Thr Thr Pro Ser Gin Leu Asp Thr Glu Val Leu Ala

85 90 95

Asn Met Leu Glu Arg He Glu Gin Leu Gin Glu Leu Asn Glu Asn Leu

100 105 110

Arg Ala Leu He Val He Asn Arg Met Pro Thr He Pro Thr Leu Lys

115 120 125

Glu Arg Gin Ala Leu He Glu Phe He Lys Glu Asn Asn Pro Ser Asp

130 135 140

Arg He Thr Leu Leu Glu Ser Ser Leu Ser Glu Arg He Val Tyr Lys 145 150 155 160

Arg Ser Val Ser Glu Gly Leu Gly Val He Glu Tyr Ser Asp Lys Lys

165 170 175

Ala He Asn Glu Trp Val Asn Phe Tyr Asn Glu Leu Lys Ser His Leu

180 185 190

Glu Lys Glu Lys He His Thr Phe 195 200

(2) INFORMATION FOR SEQ ID NO: 825:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 70 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...70

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 825 :

Met Arg Ser Asp Val Glu Val Leu Ser Pro Leu His Lys He Asp Glu

1 5 10 15

Lys Tyr Leu Phe His Leu Lys He Ala Gly Glu Leu Ala Ser Met Gly

20 25 30

Lys He Leu Ser Val Tyr Leu Ala His Lys His Ser Ala Tyr Phe He

35 40 45

Leu Asn Ala Leu Ser Tyr Gly Phe Ser His Gin Asp Arg Ala He He

50 55 60

Cys Leu Leu Gly Ala He 65 70

(2) INFORMATION FOR SEQ ID NO: 826:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 70 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL : YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 70

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 826:

Met Ser Ala Met Met Pro Ser Leu Leu Thr Leu Gin Trp Leu Ser Phe

1 5 10 15

He Leu Ser Leu Ala Glu Asn Leu Cys Leu Thr Asp Ser His His Leu

20 25 30

Lys Tyr Thr Leu Glu Lys Asn Lys Leu Val He His Ser Asn Asp Ala

35 40 45

Leu Tyr Leu Ala Lys Glu Met Leu Pro Lys Leu He Lys Pro He Pro

50 55 60

Leu Thr He Glu Phe Ala 65 70

(2) INFORMATION FOR SEQ ID NO: 827:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 478 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 478

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 827 :

Leu Lys Lys He Ala Leu He Leu Asp Gly He Val Ala Lys Asn Phe

1 5 10 15

Leu Asp Leu Val Leu Arg His Tyr Ser Asn His Asn Phe Tyr He Val

20 25 30

Val Val Lys Asp Glu Ser Leu He Pro Lys Asn Tyr Pro Ser Thr Phe

35 40 45

Ala Phe His Cys Phe Asp Ala Thr Ser Ser Phe Arg Leu Leu Gin Val

50 55 60

Leu Asn Asp Glu Val Ser Asp Ala Phe Leu He He Gin Asp Phe Lys 65 70 75 80

Glu Gin Arg He He His Lys He He Gin Thr His Phe Lys Arg Met 85 90 95 Arg Val Val Leu Ser Val Lys Arg Asp Ser Glu Lys Thr Leu Glu Asn

100 105 110

Asn Glu Glu Asn Lys Asp Glu Lys Leu He Leu He Asp Glu Phe Glu

115 120 125

Val Leu Ala Asn Lys Phe He Ser Arg Leu Pro Asn He Pro Ser Thr

130 135 140

Pro Arg Glu Phe Gly Leu Gly Lys Gly Glu He Met Glu He Asp Val 145 150 155 160

Pro Phe Gly Ser He Phe Ala Tyr Arg His He Gly Ser He Arg Gin

165 170 175

Lys Glu Tyr Arg He Val Gly Leu Tyr Arg Asn Asp Val Leu Leu Leu

180 185 190

Ser Thr Lys Ser Leu Val He Gin Pro Arg Asp He Leu Leu Val Ala

195 200 205

Gly Asn Pro Glu He Leu Asn Ala Val Tyr His Gin Val Lys Ser Asn

210 215 220

Val Gly Gin Phe Pro Ala Pro Phe Gly Lys Ser He Tyr Leu Tyr He 225 230 235 240

Asp Met Arg Leu Gin Ser Arg Lys Ala Met Met Arg Asp Val Tyr Gin

245 250 255

Ala Leu Phe Leu His Lys Arg Leu Lys Ser Tyr Lys Leu Tyr He Gin

260 265 270

Val Leu His Pro Thr Ser Pro Lys Phe Tyr His Lys Phe Leu Ser Leu

275 280 285

Glu Thr Glu Ser He Glu Val Asn Phe Asp Phe Tyr Gly Lys Ser Phe

290 295 300

He Gin Lys Leu His Glu Asp His Gin Lys Lys Met Gly Leu He Val 305 310 315 320

Val Gly Arg Glu Leu Phe Phe Leu Lys Lys His Arg Arg Ala Leu His

325 330 335

Lys Thr Ala Thr Pro Val Tyr Lys Thr Asn Thr Ser Gly Leu Ser Lys

340 345 350

Thr Thr Gin Ser He Val Val Leu Asn Glu Ser Leu Ser He Asn Glu

355 360 365

Asp Met Ser Ser Val He Phe Asp Val Ser Met Gin Met Asp Leu Gly

370 375 380

Leu Leu Leu Tyr Asp Phe Asp Pro Asn Lys His Tyr Lys Asn Glu He 385 390 395 400

Val Asn His Tyr Glu Asn Leu Ala Asn Thr Phe Asn Arg Lys He Glu

405 410 415

He Phe Gin Thr Asp He Lys Asn Pro He Met Tyr Leu Asn Ser Leu

420 425 430

Arg Asn Pro He Leu His Phe Met Pro Phe Glu Glu Cys He Thr Gin

435 440 445

Thr Arg Tyr Leu Trp Phe Leu Ser Thr Lys Val Glu Lys Leu Ala Phe

450 455 460

Leu Asn Asp Asp His Pro Gin He Phe He Pro Val Ala Glu 465 470 475

(2) INFORMATION FOR SEQ ID NO: 828:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 418 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...418

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 828:

Met Lys Lys Val Tyr Phe Lys Thr Phe Gly Cys Arg Thr Asn Leu Phe

1 5 10 15

Asp Thr Gin Val Met Gly Glu Asn Leu Lys Asp Phe Ser Ala Thr Leu

20 25 30

Glu Glu Gin Glu Ala Asp He He He He Asn Ser Cys Thr Val Thr

35 40 45

Asn Gly Thr Asp Ser Ala Val Arg Ser Tyr Ala Arg Lys Met Ala Arg

50 55 60

Leu Asp Lys Glu Val Leu Phe Thr Gly Cys Gly Val Lys Thr Gin Gly 65 70 75 80

Lys Glu Leu Phe Glu Lys Gly Leu Leu Lys Gly Val Phe Gly His Asp

85 90 95

Asn Lys Glu Lys He Asn Ala Leu Leu Gin Glu Lys Lys Arg Phe Phe

100 105 110

He Asp Asp Asn Leu Glu Asn Lys His Leu Asp Thr Thr Met Val Ser

115 120 125

Glu Phe Val Gly Lys Thr Arg Ala Phe He Lys He Gin Glu Gly Cys

130 135 140

Asp Phe Asp Cys Asn Tyr Cys He He Pro Ser Val Arg Gly Arg Ala 145 150 155 160

Arg Ser Phe Glu Glu Arg Lys He Leu Glu Gin Val Gly Leu Leu Cys

165 170 175

Ser Lys Gly Val Gin Glu Val Val Leu Thr Gly Thr Asn Val Gly Ser

180 185 190

Tyr Gly Lys Asp Arg Gly Ser Asn He Ala Arg Leu He Lys Lys Leu

195 200 205

Ser Gin He Thr Gly Leu Lys Arg He Arg He Gly Ser Leu Glu Pro

210 215 220

Asn Gin He Asn Asp Glu Phe Leu Glu Leu Leu Glu Glu Asp Phe Leu 225 230 235 240

Glu Lys His Leu His He Ala Leu Gin His Ser His Asp Phe Met Leu

245 250 255

Glu Arg Met Asn Arg Arg Asn Arg Thr Lys Ser Asp Arg Glu Leu Leu

260 265 270

Glu He He Ala Ser Lys Asn Phe Ala He Gly Thr Asp Phe He Val

275 280 285

Gly His Pro Gly Glu Ser Glu Ser Val Phe Glu Lys Ala Phe Lys Asn

290 295 300

Leu Glu Ser Leu Pro Leu Thr His He His Pro Phe He Tyr Ser Lys 305 310 315 320

Arg Lys Asp Thr Pro Ser Ser Leu Met Arg Asp Ser Val Ser Leu Glu

325 330 335

Asp Ser Lys Lys Arg Leu Asn Ala He Lys Asp Leu He Phe His Lys

340 345 350

Asn Lys Ala Phe Arg Gin Leu Gin Leu Lys Leu Asn Thr Pro Leu Lys 355 360 365

Ala Leu Val Glu Ala Gin Lys Asp Gly Glu Phe Lys Ala Leu Asp Gin

370 375 380

Phe Phe Asn Pro He Lys He Lys Ser Asp Lys Pro Leu Arg Ala Ser 385 390 395 400

Phe Leu Glu He Lys Glu Tyr Glu He Lys Glu Arg Glu Asn His Ala

405 410 415

Val Phe

(2) INFORMATION FOR SEQ ID NO: 829:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 175 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A ) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 175

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 829 :

Leu Lys He Ala Tyr Arg Leu Leu Gly Leu Met Ser Phe He Ala Leu

1 5 10 15

Val Leu Ala He Val Leu He Ser He Leu Pro Leu Gin Lys Thr Glu

20 25 30

His His Phe Val Asp Phe Leu Asn Gin Asp Lys His Tyr Ala He He

35 40 45

Gin Arg Ala Asp Lys Ser He Ser Ser Asn Glu Ala Leu Ala Arg Ser

50 55 60

Leu He Gly Ala Tyr Val Leu Asn Arg Glu Ser He Asn Arg He Asp 65 70 75 80

Asp Lys Ser Arg Tyr Glu Leu Val Arg Leu Gin Ser Ser Ser Lys Val

85 90 95

Trp Gin Arg Phe Glu Asp Leu He Lys Ala Gin Asn Ser He Tyr Val

100 105 110

Gin Ser His Leu Glu Arg Glu Val His He Val Asn He Ala He Tyr

115 120 125

Gin Gin Asp Asn Asn Pro He Ala Ser Val Ser He Ala Ala Lys Leu

130 135 140

Leu Asn Glu Asn Lys Leu Val Tyr Glu Lys Arg Tyr Lys He Val Leu 145 150 155 160

Ser Tyr Leu Phe Asp Thr Pro Asp Phe Asp Tyr Ala Ser Met Pro 165 170 175

(2) INFORMATION FOR SEQ ID NO: 830:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 186 amino acids

(D) TOPOLOGY linear

(11 ) MOLECULE TYPE protein

(ill) HYPOTHETICAL . YES

(vi ) ORIGINAL SOURCE:

(A) ORGANISM- Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...186

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 830 :

Leu Leu Leu Val Ser Arg Phe Leu Asn Ala He Asp Pro Phe Asn Leu

1 5 10 15

Gly Val Leu Leu Ser Arg Phe Gin He Lys Asn Gly Cys He Tyr Gly

20 25 30

Val Cys Ser Tyr Lys Val Ser Lys Phe Thr Pro Gly Tyr Glu Glu Ser

35 40 45

Lys Ala Arg Val Leu Asn Ala Leu Asn He Leu Ser Lys His Gin He

50 55 60

Trp Gin Ser Asn Gin Glu Ser Val Thr Lys Val Lys Gly Thr Phe Val 65 70 75 80

Phe He Leu Glu Asn Asp Leu His Leu Asp Glu Asn Ser Phe Tyr Lys

85 90 95

Lys Leu Leu Asn Leu He He Asp Asn Asp Phe Phe Asn Arg Ser His

100 105 110

Leu Val Thr Pro Ser Asn Gly Thr Asn Ser His Pro Glu Leu His Arg

115 120 125

Ser He Thr Pro Arg Glu Ala Ala Arg He Gin Ser Phe Ser Asp Asp

130 135 140

Tyr He Phe Tyr Gly Asn Lys Thr Ser Val Cys Lys Gin He Gly Asn 145 150 155 160

Ala Val Pro Pro Leu Leu Ala Leu Ala Leu Gly Lys Ala He Leu Lys

165 170 175

Ser Ala Arg Asn Asp Thr Asn Pro Ser Arg 180 185

(2) INFORMATION FOR SEQ ID NO: 831:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 173 ammo acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature ( B ) LOCATION 1 . . . 173

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 831 :

Met Gly Leu Lys Asn Lys He Lys Gly Phe Val Lys Glu Arg Met Pro

1 5 10 15

Phe Val Met Arg Cys Val Arg Gly Leu Lys Gly Ala Lys Asp Thr His

20 25 30

Glu Asn Ala His Asp Arg Asp Ala Tyr Cys Gly He Asn Arg Glu He

35 40 45

Lys Glu Met Leu Glu Ala Lys Lys Leu His Phe Leu Gin Glu Lys Ala

50 55 60

Leu Phe Asn His Asp His Gin Glu Ser Val Phe Leu Ala He Ala Ser 65 70 75 80

Leu Asn Asn Glu Ser Phe He Glu Tyr Asn Lys Ser He Tyr Lys Asn

85 90 95

Ser Ser Leu Asn Tyr Asn Tyr Gly Gly His Leu Glu Asp Arg Val He

100 105 110

His Pro Thr Leu Thr Leu Pro Asn Pro Thr His Ser Gly Tyr Phe Asp

115 120 125

Tyr Asp Lys Lys Ser Gin Asn Pro Lys Ser Pro Leu Asn Pro Trp Ala

130 135 140

Phe He Arg Val Lys Asn Glu He Val Thr Leu Glu Glu Ser Leu Phe 145 150 155 160

Ser Met Leu Pro Ala Val Gin Arg Gly Gly His Trp Phe 165 170

(2) INFORMATION FOR SEQ ID NO: 832:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 175 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...175

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 832 :

Leu Trp Hi s Gin Leu Tyr Hi s Tyr Cys Asn Tyr Thr Leu Ser Phe He

1 5 10 15

Pro Lys Asn Glu Trp Val Val Lys He Asp Cys Asp His He Tyr Asp

20 25 30

Ala Lys Lys Leu Tyr Lys Ser Phe Tyr He Pro Lys Asn He Lys Glu

35 40 45

Val Val Met Tyr Ser Arg He Asn Phe Val Val Arg Asp Phe Glu Val

50 55 60

Phe Val Arg Asn Asp Gly Asp Phe Gly Phe Leu Asp Ala Trp Gly Asp 65 70 75 80 His Trp Leu Leu Tyr Asn Asp Cys Glu Pro Phe Glu He Trp Arg Tyr

85 90 95

Asn Asp Glu Ser Tyr Glu Val Leu Lys Leu Lys Asp Lys His His He

100 105 110

Lys Asp Lys Glu Met Val Gin Trp His Phe Pro Leu Ala Lys Lys Arg

115 120 125

Arg Asn Ala He Val Tyr Asp Asp Leu He Pro Leu Glu Glu Phe Lys

130 135 140

Lys Arg His Ala Asp Leu He Gly Thr Arg He Glu Glu Ser Met Leu

145 150 155 160

Asp Glu Lys Arg He Leu Glu Val Tyr Gin Lys Phe Arg Leu Pro 165 170 175

(2) INFORMATION FOR SEQ ID NO: 833:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 357 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 357

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 833:

Met Gin Lys Pro Gin Asn Lys Pro Ser Ser Ser Gin Gin Ser Pro Gin

1 5 10 15

Asn Phe Ser Tyr Pro Glu Ser Lys Leu Gly Ser Lys Asn Ser Lys Asn

20 25 30

Ser Leu Leu Gin Pro Leu Val Thr Pro Ser Lys Val Ser Pro Thr Asn

35 40 45

Glu Val Lys Thr Pro Thr Asn Asp Ala Asn Pro Pro Leu Lys His Ser

50 55 60

Ser Gin Asp Gin Glu Asn Asn Leu Phe Val Ala Pro Pro Thr Glu Lys 65 70 75 80

Thr Leu Pro Asn Asn Thr Ser Ser Ala Asp Ala Ser Glu Asn Asn Glu

85 90 95

Ser Asn Glu Asn Arg Asp Asn Val Glu Lys Gin Ala He Arg Asp Pro

100 105 110

Asn He Lys Glu Phe Ala Cys Gly Lys Trp Val Tyr Asp Asp Glu Asn

115 120 125

Leu Gin Ala Tyr Arg Pro Ser He Leu Lys Arg Val Asp Lys Asp Lys

130 135 140

Glu He Thr Thr Asp He Thr Pro Cys Asp Tyr Ser Thr Ala Glu Asn 145 150 155 160

Lys Ser Gly Lys He He Thr Pro Tyr Thr Lys He Ser Val His Lys

165 170 175

Thr Glu Pro Leu Glu Asp Pro Gin Thr Phe Glu Ala Lys Asn Asn Phe 180 185 190 Ala He Leu Gin Ala Arg Ser Ser Thr Glu Lys Cys Lys Arg Ala Arg

195 200 205

Ala Arg Lys Asp Gly Thr Thr Arg Gin Cys Tyr Leu He Glu Glu Pro

210 215 220

Leu Lys Gin Ala Trp Glu Ser Glu Tyr Glu He Thr Thr Gin Leu Val 225 230 235 240

Lys Ala He Tyr Glu Arg Pro Lys Gin Asp Asp Gin Val Glu Pro Thr

245 250 255

Phe Tyr Glu Thr Ser Glu Leu Ala Tyr Ser Ser Thr Arg Lys Ser Glu

260 265 270

He Thr Arg Asn Glu Leu Asn Leu Asn Glu Lys Phe Met Glu Phe Val

275 280 285

Glu Val Tyr Glu Gly His Tyr Leu Asn Asp He He Lys Glu Ser Ser

290 295 300

Glu Tyr Lys Glu Trp Val Lys Asn His Val Arg Phe Lys Glu Gly Val 305 310 315 320

Cys Met Ala Leu Glu He Glu Glu Gin Pro Arg Ala Lys Ser Thr Pro

325 330 335

Leu Ser He Glu Asn Ser Arg Val Val Cys Val Lys Lys Gly Asn Tyr

340 345 350

Leu Phe Asn Glu Val 355

(2) INFORMATION FOR SEQ ID NO: 834:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 143 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 143

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 834 :

He Gin Tyr Pro Lys Ser Ser Phe Phe Gin Lys Arg Gly Arg Asn Gly

1 5 10 15

Asn His Ser Thr He Gin Pro Phe Asn His Ser Thr He Gin Pro Phe

20 25 30

Asn His Ser He He Gin Ser Phe Asn His Ser He He Gin Ser Phe

35 40 45

Asn His Ser He He Gin Ser Phe Asn His Ser Thr He Gin Ala Thr

50 55 60

Leu Pro Tyr Phe Tyr Asn Tyr Leu Ser Phe Tyr Lys Asn Leu Phe Lys 65 70 75 80

Asn Pro Leu Phe Phe He He Pro Pro Phe He Asn Pro Phe He Asn

85 90 95

Pro Phe He Asn Pro Phe He Asn Pro Phe He Asn Pro Phe He Asn 100 105 110 Pro Phe He Asn Pro Phe He Asn Pro Phe He Asn Pro Phe He Asn

115 120 125

Pro Phe He Asn Pro Phe He Asn Pro Phe He Asn Pro Phe He

130 135 140

(2) INFORMATION FOR SEQ ID NO: 835:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 242 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...242

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 835 :

Leu Lys Val Asn Phe Phe Ala Thr Cys Leu Gly Ala Ala He Tyr Ser

1 5 10 15

Asn Ala Ser Leu Asn Ala He Lys Leu Leu Arg Lys Glu Asn Leu Glu

20 25 30

Val Val Phe Lys Lys Asp Gin Thr Cys Cys Gly Gin Pro Ser Tyr Asn

35 40 45

Ser Gly Tyr Tyr Glu Glu Thr Lys Lys Val Val Leu Tyr Asn He Lys

50 55 60

Leu Tyr Ser Asn Asn Asp Tyr Pro He He Leu Pro Ser Gly Ser Cys 65 70 75_. 80

Thr Gly Met Met Arg His Asp Tyr Leu Glu Leu Phe Glu Gly His Ala

85 90 95

Glu Phe Asn Met Val Lys Asp Phe Cys Ser Arg Val Tyr Glu Leu Ser

100 105 110

Glu Phe Leu Asp Lys Lys Leu Gin Val Lys Tyr Glu Asp Lys Gly Glu

115 120 125

Pro Leu Lys He Thr Trp His Ser Asn Cys His Ala Leu Arg Val Ala

130 135 140

Lys Val He Asp Ser Ala Lys Asn Leu He Arg Gin Leu Lys Asn Val 145 150 155 160

Glu Leu He Glu Leu Glu Lys Glu Glu Glu Cys Cys Gly Phe Gly Gly

165 170 175

Thr Phe Ser Val Lys Glu Pro Glu He Ser Ala Val Met Val Lys Glu

180 185 190

Lys He Lys Asp He Glu Ser Arg His Val Asp Val He Val Ser Ala

195 200 205

Asp Ala Gly Cys Leu Met Asn He Ser Thr Ala Met Gin Lys Met Gly

210 215 220

Ser Leu Thr Lys Pro Met His Phe Tyr Asp Phe Leu Ala Ser Arg Leu 225 230 235 240

Gly Leu (2) INFORMATION FOR SEQ ID NO 836

(l) SEQUENCE CHARACTERISTICS-

(A) LENGTH 401 ammo acids

(D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(ill) HYPOTHETICAL- YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...401

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 836 :

Met He Phe Gly Asp Phe Lys Tyr Gin Lys Ser Val Lys Lys Leu Thr

1 5 10 15

Ala Thr Asn Leu Asn Glu Leu Lys Asn Ala Leu Asp Phe He Ser Gin

20 25 30

Asn Arg Gly Lys Gly Tyr Phe Val Gly Tyr Leu Leu Tyr Glu Ala Arg

35 40 45

Leu Ala Phe Leu Asp Glu Asn Phe Gin Ser Gin Thr Pro Phe Leu Tyr

50 55 60

Phe Glu Gin Phe Leu Glu Arg Lys Lys Tyr Pro Leu Glu Pro Leu Lys 65 70 75 80

Glu His Ala Phe Tyr Pro Lys He His Ser Ser Leu Asp Gin Lys Thr

85 90 95

Tyr Phe Lys Gin Phe Lys Ala Val Lys Glu His Leu Lys Asn Gly Asp

100 105 110

Thr Tyr Gin Val Asn Leu Thr Met Asp Leu Leu Leu Asn Thr Lys Ala

115 120 125

Lys Pro Lys Arg Val Phe Lys Glu Val He His Asn Gin Asn Thr Pro

130 135 140

Phe Lys Ala Phe He Glu Asn Glu Phe Gly Ser Val Leu Ser Phe Ser 145 150 155 160

Pro Glu Leu Phe Phe Glu Leu Glu Phe Leu Asp Thr Ala He Lys He

165 170 175

He Thr Lys Pro Met Lys Gly Thr He Ala Arg Ser Asn Asn Pro Leu

180 185 190

He Asp Glu Lys Asn Arg Leu Phe Leu Gin Asn Asp Asp Lys Asn Arg

195 200 205

Ser Glu Asn Val Met He Val Asp Leu Leu Arg Asn Asp Leu Ser Arg

210 215 220

Leu Ala Leu Lys Asn Ser Val Lys Val Asn Gin Leu Phe Glu He He 225 230 235 240

Ser Leu Pro Ser Val Tyr Gin Met He Ser Glu He Glu Ala Gin Leu

245 250 255

Pro Leu Lys Thr Ser Leu Phe Glu He Phe Lys Ala Leu Phe Pro Cys

260 265 270

Gly Ser Val Thr Gly Cys Pro Lys He Lys Thr Met Gin He He Glu 275 280 285 Ser Leu Glu Lys Arg Pro Arg Gly Val Tyr Cys Gly Ala He Gly Met

290 295 300

Val Gly Gly Lys Lys Ala Leu Phe Ser Val Pro He Arg Thr Leu Glu 305 310 315 320

Lys Arg Ala His Glu Asp Phe Leu His Leu Gly Val Gly Ser Gly Val

325 330 335

Thr Tyr Lys Ser Lys Ala Ser Lys Glu Tyr Glu Glu Ser Phe Leu Lys

340 345 350

Ser Phe Phe Val Met Pro Lys He Glu Phe Glu He Val Glu Thr Met

355 360 365

Arg Val He Lys Arg Asp Gin Lys Leu Glu He Asn Asn Lys Asn Ala

370 375 380

His Lys Glu Arg Leu Met His Ser Ala Gin Tyr Phe Asn Phe Lys Tyr 385 390 395 400

Arg

(2) INFORMATION FOR SEQ ID NO: 837:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 264 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 264

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 837 :

Met Lys He Ser Val Ser Lys Asn Asp Leu Glu Asn Thr Leu Arg Tyr

1 5 10 15

Leu Gin Ala Phe Leu Asp Lys Lys Asp Ala Ser Ser He Ala Ser His

20 25 30

He His Leu Glu Val He Lys Glu Lys Leu Phe Leu Lys Ala Ser Asp

35 40 45

Ser Asp He Gly Leu Lys Ser Tyr He Ser Thr Gin Ser Thr Asp Lys

50 55 60

Glu Gly Val Gly Thr He Asn Gly Lys Lys Phe Leu Asp He He Ser 65 70 75 80

Cys Leu Lys Asp Ser Asn He Val Leu Glu Thr Lys Asp Asp Ser Leu

85 90 95

Val He Lys Gin Asn Lys Ser Ser Phe Lys Leu Pro Met Phe Asp Ala

100 105 110

Asp Glu Phe Pro Glu Phe Pro Val He Asp Pro Lys Val Ser Leu Glu

115 120 125

He Asn Ala Pro Phe Leu Val Asp Ala Phe Lys Lys He Ala Pro Val

130 135 140

He Glu Gin Thr Ser His Lys Arg Glu Leu Ala Gly Val Leu Met Gin 145 150 155 160 Phe Asn Gin Lys His Gin Thr Leu Ser Val Val Gly Thr Asp Thr Lys

165 170 175

Arg Leu Ser Tyr Thr Gin Leu Glu Lys He Ser He His Ser Thr Glu

180 185 190

Glu Asp He Ser Cys He Leu Pro Lys Arg Ala Leu Leu Glu He Leu

195 200 205

Lys Leu Phe Tyr Glu Asn Phe Ser Phe Lys Ser Asp Gly Met Leu Ala

210 215 220

Val Val Glu Asn Glu Thr His Ala Phe Phe Thr Lys Leu He Asp Gly 225 230 235 240

Asn Tyr Pro Asp Tyr Gin Lys He Leu Pro Lys Glu Tyr Thr Ser Ser

245 250 255

Phe Thr Leu Gly Lys Glu Glu Phe 260

(2) INFORMATION FOR SEQ ID NO: 838:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 312 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 312

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 838:

Leu Asn Asn Leu Glu Pro Leu Gly Ala Glu Val Phe Val Gly Leu Asp

1 5 10 15

Gly He Asp Ala Met He Glu Glu Cys Val Ser Asn Leu Val He Asn

20 25 30

Ala He Val Gly Val Ala Gly Leu Lys Ala Ser Phe Lys Ser Leu Gin

35 40 45

Arg Asn Lys Lys Leu Ala Leu Ala Asn Lys Glu Ser Leu Val Ser Ala

50 55 60

Gly His Leu Leu Asp He Ser Gin He Thr Pro Val Asp Ser Glu His 65 70 75 80

Phe Gly Leu Trp Ala Leu Leu Gin Asn Lys Thr Leu Lys Pro Lys Ser

85 90 95

Leu He He Ser Ala Ser Gly Gly Ala Phe Arg Asp Thr Pro Leu Asp

100 105 110

Leu He Ala He Gin Asn Ala Gin Asn Ala Leu Lys His Pro Asn Trp

115 120 125

Ser Met Gly Asp Lys He Thr He Asp Ser Ala Ser Met Val Asn Lys

130 135 140

Leu Phe Glu He Leu Glu Thr Tyr Trp Leu Phe Gly Ala Ser Leu Lys 145 150 155 160

He Asp Ala Leu He Glu Arg Ser Ser He Val His Ala Leu Val Glu 165 170 175 Phe Glu Asp Asn Ser Val He Ala His Leu Ala Ser Ala Asp Met Gin

180 185 190

Leu Pro He Ser Tyr Ala He Asn Pro Lys Leu Ala Ser Leu Ser Ala

195 200 205

Ser He Lys Pro Leu Asp Leu Tyr Ala Leu Ser Ala He Lys Phe Glu

210 215 220

Pro He Ser Val Glu Arg Tyr Thr Leu Trp Arg Tyr Lys Asp Leu Leu 225 230 235 240

Leu Glu Asn Pro Lys Leu Gly Val Val Leu Asn Ala Ser Asn Glu Val

245 250 255

Ala Met Lys Lys Phe Leu Asn Gin Glu He Ala Phe Gly Gly Phe He

260 265 270

Gin He He Ser Gin Ala Leu Glu Leu Tyr Ala Lys Lys Ser Phe Lys

275 280 285

Leu Ser Ser Leu Asp Glu Val Leu Ala Leu Asp Lys Glu Val Arg Glu

290 295 300

Arg Phe Gly Ser Val Ala Arg Val 305 310

(2) INFORMATION FOR SEQ ID NO: 839:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 290 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...290

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 839:

Met Leu Glu Asn Val Lys Lys Ser Leu Phe Arg Val Leu Cys Leu Gly

1 5 10 15

Ala Leu Cys Leu Gly Gly Leu Met Ala Glu Gin Asp Pro Lys Glu Leu

20 25 30

Val Gly Leu Gly Ala Lys Ser Tyr Lys Glu Gin Asp Phe Thr Gin Ala

35 40 45

Lys Lys Tyr Phe Glu Lys Ala Cys Asp Leu Lys Glu Asn Ser Gly Cys

50 55 60

Phe Asn Leu Gly Val Leu Tyr Tyr Gin Gly His Gly Val Glu Lys Asn 65 70 75 80

Leu Lys Lys Ala Ala Ser Phe Tyr Ser Lys Ala Cys Asp Leu Asn Tyr

85 90 95

Ser Asn Gly Cys His Leu Leu Gly Asn Leu Tyr Tyr Ser Gly Gin Gly

100 105 110

Val Ser Gin Asn Thr Asn Lys Ala Leu Gin Tyr Tyr Ser Lys Ala Cys

115 120 125

Asp Leu Lys Tyr Ala Glu Gly Cys Ala Ser Leu Gly Gly He Tyr His 130 135 140 Asp Gly Lys Val Val Thr Arg Asp Phe Lys Lys Ala Val Glu Tyr Phe 145 150 155 160

Thr Lys Ala Cys Asp Leu Asn Asp Gly Asp Gly Cys Thr He Leu Gly

165 170 175

Ser Leu Tyr Asp Ala Gly Arg Gly Thr Pro Lys Asp Leu Lys Lys Ala

180 185 190

Leu Ala Ser Tyr Asp Lys Ala Cys Asp Leu Lys Asp Ser Pro Gly Cys

195 200 205

Phe Asn Ala Gly Asn Met Tyr His His Gly Glu Gly Ala Ala Lys Asn

210 215 220

Phe Lys Glu Ala Leu Ala Arg Tyr Ser Lys Ala Cys Glu Leu Glu Asn 225 230 235 240

Gly Gly Gly Cys Phe Asn Leu Gly Ala Met Gin Tyr Asn Gly Glu Gly

245 250 255

Ala Thr Arg Asn Glu Lys Gin Ala He Glu Asn Phe Lys Lys Gly Cys

260 265 270

Lys Leu Gly Ala Lys Gly Ala Cys Asp He Leu Lys Gin Leu Lys He

275 280 285

Lys Val 290

(2) INFORMATION FOR SEQ ID NO: 840:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 237 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 237

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 840 :

Met Lys Ser Asn Lys Lys Ser Asn His Leu Arg Ala He Tyr Arg Ala

1 5 10 15

Leu Val He Ala He Gly Leu Ala Val He He Val Phe Asn Tyr Phe

20 25 30

Asn Arg Lys Asn Asn Asn Ala Arg Ser Ser Arg Arg Ala Cys Ser Cys

35 40 45

Phe Phe Ser Leu Thr Gly Val Asn Leu Glu Lys He Gly Ser Phe Asp

50 55 60

Thr Gly Ala Lys Leu He Val Leu Asn His Gin Ser Leu Leu Asp He 65 70 75 80

He Tyr Leu Glu Ala Tyr His Pro Ser Asn He Cys Trp He Ala Lys

85 90 95

Lys Glu Leu Gly Glu He Pro Phe Tyr Gly His Ala Leu Thr Asp Thr

100 ^'105 110

Gly Met He Leu He Asp Arg Glu Asp Lys Lys Gly He Val Ser Leu 115 120 125 Leu Lys Ala Cys Lys Glu Lys Leu Asp Gin Asn Arg Pro Leu Val He

130 135 140

Phe Pro Glu Gly Thr Arg Gly Lys Gly Gly Glu Lys Phe Leu Pro Phe 145 150 155 160

Lys Gin Gly Ala Lys He He Ala Glu Lys Phe Gin Leu Lys He Gin

165 170 175

Pro Met Val Leu He Asn Ser He Lys He Phe Asn Ser Lys Pro Leu

180 185 190

Glu Ala Tyr Lys Ala Arg Thr Arg Leu Val Met Leu Glu Ser Tyr Thr

195 200 205

Pro Asp Phe Ser Ser Pro Thr Trp Tyr Glu Glu Leu Gin Glu Arg Met

210 215 220

Gin Lys Glu Tyr Leu Lys His Tyr His Glu Leu Asn Ala 225 230 235

(2) INFORMATION FOR SEQ ID NO: 841:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 681 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...681

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 841 :

Met Gly Phe Glu Lys Ser He Leu Asp Asn Leu Asn Gly Ala Gin Lys

1 5 10 15

He Ala Ala Cys His He Gin Gly Pro Leu Leu He Leu Ala Gly Ala

20 25 30

Gly Ser Gly Lys Thr Lys Thr Leu Thr Ser Arg Leu Ala Tyr Leu He

35 40 45

Gly Ala Cys Gly Val Pro Ser Glu Asn Thr Leu Thr Leu Thr Phe Thr

50 55 60

Asn Lys Ala Ser Lys Glu Met Gin Glu Arg Ala Leu Lys Leu Leu Lys 65 70 75 80

Asn Gin Ala Leu He Pro Pro Leu Leu Cys Thr Phe His Arg Phe Gly

85 90 95

Leu Leu Phe Leu Arg Gin His Met Asn Leu Leu Lys Arg Ala Cys Asp

100 105 110

Phe Ser Val Leu Asp Ser Asp Glu Val Lys Thr Leu Cys Lys Gin Leu

115 120 125

Lys He Ser Asn Phe Arg Ala Ser He Ser Gin He Lys Asn Gly Met

130 135 140

Met Asp Leu Ser Val Gin Asp Ser Glu Cys Tyr Lys Ala Tyr Glu Leu 145 150 155 160

Tyr Gin Asn Ala Leu Lys Lys Asp Asn Leu Val Asp Phe Asp Asp Leu 165 170 175 Leu Cys Leu Ser Leu Lys He Leu Gin Asp Asn Glu Lys Leu Ala Lys

180 185 190

Glu Thr Ser Glu Arg Tyr His Tyr He Met Val Asp Glu Tyr Gin Asp

195 200 205

Thr Asn Ala Leu Gin Leu Glu Phe Leu Lys Gin Leu Ser Phe Thr His

210 215 220

His Asn Leu Cys Val Val Gly Asp Asp Asp Gin Ser He Tyr Gly Phe 225 230 235 240

Arg Gly Ala Asp He Ser Asn He Leu Asn Phe Ser Lys His Phe Lys

245 250 255

Gly Ala Lys He Val Lys Leu Glu Thr Asn Tyr Arg Ser Ser Ala Glu

260 265 270

He Leu Ala Cys Ala Asn Ser Leu He Ser His Asn Gin His Arg His

275 280 285

He Lys Thr Leu Gin Ser Phe Lys Gly Ser His Lys Ser Val He Cys

290 295 300

Lys Glu Tyr Pro Thr Gin Lys Glu Glu Ser Leu Asp Val Ala Tyr Gin 305 310 315 320

He Lys Ala Leu Leu Lys Lys Gly Glu Asn Leu Glu Asn He Ala He

325 330 335

Leu Tyr Arg Leu Asn Gly Leu Ser Arg Ser He Glu Glu Ser Leu Asn

340 345 350

Ala Leu Asn He Pro Tyr Arg Leu He Gly Ala Val Ser Phe Tyr Glu

355 360 365

Arg Ala Glu Val Lys Asp Ala Leu Ala Leu Met His Val Val Ala Lys

370 375 380

Lys Asp Asp Arg Phe Phe He Lys Arg Val Leu Asn Lys Pro Pro Arg 385 390 395 400

Gly Leu Gly Lys He Thr Gin Glu Trp He Phe Ser Leu Leu Asp Glu

405 410 415

Glu Gly Leu Asn Leu Glu Glu Ala Leu Lys He Gly Ala Phe Lys Asp

420 425 430

Lys Leu Asn Pro Lys Asn Glu Tyr Ala Leu Lys Lys Phe Thr Ala Met

435 440 445

He Gly Arg Leu Arg Glu Ala Phe Glu He Ser Val Glu Lys Phe Cys

450 455 460

Glu Arg Phe Leu Glu Glu Thr Asn Leu Leu Lys Ser Tyr Glu Lys Glu 465 470 475 480

Asp Asn Tyr Glu Glu Arg Glu Gly Phe Val Lys Glu Leu Leu Ser Leu

485 490 495

Val Lys Glu His Phe Lys Thr Asn Pro Thr His Ser Leu Leu Asp Phe

500 505 510

Leu Asn Glu Ser Ala Leu Asp Val His Asn Thr Glu Asn Ala Gin Lys

515 520 525

Val Ser Cys Met Ser Val His Met Ser Lys Gly Leu Glu Phe Lys His

530 535 540

Val Phe Val He Gly Leu Glu Glu Gly Phe Phe Pro His Arg Gly Phe 545 550 555 560

Asn Gin Glu Ser Asp Leu Glu Glu Glu Arg Arg Leu Ala Tyr Val Ala

565 570 575

He Thr Arg Ala Lys Glu Glu Leu Gin Leu Ser Tyr Val Lys Glu Arg

580 585 590

Ser Tyr Phe Gly Arg Lys He Ser Cys Ser Pro Ser Val Phe Leu Glu

595 600 605

Glu Ala Gin Leu Leu Gin Gin Asp Lys Pro Pro Lys Gin Asn His Gin

610 615 620

Lys Asp Thr Pro He Lys Val Gly Asp Leu He Lys His Lys He Phe 625 630 635 640

Gly Thr Gly Arg Val Leu Gly Val Glu Lys Gly Leu Ser Gly Leu Cys

645 650 655

Leu Lys He Asn Cys Gly Gly Asn Val Tyr Asp Lys He Ser Glu Lys

660 665 670

Phe Val Glu Lys Val Asp Asn Glu Phe 675 680

(2) INFORMATION FOR SEQ ID NO: 842:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 276 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A ) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 276

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 842 :

Met Lys Thr Ser Asn Thr Lys Thr Pro Lys Pro Val Leu He Ala Gly

1 5 10 15

Pro Cys Val He Glu Ser Leu Glu Asn Leu Arg Ser He Ala He Lys

20 25 30

Leu Gin Pro Leu Ala Asn Asn Glu Arg Leu Asp Phe Tyr Phe Lys Ala

35 40 45

Ser Phe Asp Lys Ala Asn Arg Thr Ser Leu Glu Ser Tyr Arg Gly Pro

50 55 60

Gly Leu Glu Lys Gly Leu Glu Met Leu Gin Thr He Lys Asp Glu Phe 65 70 75 80

Gly Tyr Lys He Leu Thr Asp Val His Glu Ser Tyr Gin Ala Ser Val

85 90 95

Ala Ala Lys Val Ala Asp He Leu Gin He Pro Ala Phe Leu Cys Arg

100 105 110

Gin Thr Asp Leu He Val Glu Val Ser Gin Thr Asn Ala He Val Asn

115 120 125

He Lys Lys Gly Gin Phe Met Asn Pro Lys Asp Met Gin Tyr Ser Val

130 135 140

Leu Lys Ala Leu Lys Thr Arg Asp Ser Ser He Gin Ser Pro Thr Tyr 145 150 155 160

Glu Thr Ala Leu Lys Asn Gly Val Trp Leu Cys Glu Arg Gly Ser Ser

165 170 175

Phe Gly Tyr Gly Asn Leu Val Val Asp Met Arg Ser Leu Lys He Met

180 185 190

Arg Glu Phe Ala Pro Val He Phe Asp Ala Thr His Ser Val Gin Met

195 200 205

Pro Gly Gly Ala Asn Gly Lys Ser Ser Gly Asp Ser Ser Phe Pro Pro

210 215 220

He Leu Pro Arg Ala Ala Ala Ala Val Gly He Asp Gly Leu Phe Ala 225 230 235 240

Glu Thr His He Asp Pro Lys Asn Ala Leu Ser Asp Gly Ala Asn Met

245 250 255

Leu Lys Pro Asp Glu Leu Glu His Leu Val Thr Asp Met Leu Lys He

260 265 270

Gin Asn Leu Phe 275

(2) INFORMATION FOR SEQ ID NO- 843

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 436 ammo acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...436

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 843:

Met Met Lys Phe Phe Leu Leu Lys Lys Phe Ser Glu Phe Leu Asn Thr

1 5 10 15

Gin Thr His Phe Asn Leu Lys Arg Leu Asn Ala Ser Ser Phe Leu Leu

20 25 30

Glu Thr Phe Ser Lys Glu Lys His Ala Phe Val Val Asp Leu Ser Ala

35 40 45

Pro Tyr He Gly Leu Ser Lys Lys Pro Pro Glu Ser Val Leu Lys Asn

50 55 60

Thr Leu Ala Leu Asp Phe Cys Leu Asn Lys Phe Thr Lys Asn Ala Lys 65 70 75 80

He Leu Gin Ala Asn Val He Asp Asn Asp Arg He Leu Glu He Lys

85 90 95

Gly Ala Lys Asp Leu Ala Tyr Lys Ser Glu Thr Phe He Leu Arg Leu

100 105 110

Glu Met He Pro Lys Lys Ala Asn Leu Met He Leu Asp Gin Glu Lys

115 120 125

Cys Val He Glu Ala Phe Arg Phe Asn Asp Arg Val Ala Lys Asn Asp

130 135 140

He Leu Gly Ala Leu Pro Pro Asn He Tyr Glu His Gin Glu Glu Asp 145 150 155 160

Leu Asp Phe Lys Gly Leu Leu Asp He Leu Glu Lys Asp Phe Leu Ser

165 170 175

Tyr Gin His Lys Glu Leu Glu His Lys Lys Asn Gin He He Lys Arg

180 185 190

Leu Asn Ala Gin Lys Glu Arg Leu Lys Glu Lys Leu Glu Lys Leu Glu

195 200 205

Asp Pro Lys Thr Leu Gin Leu Glu Ala Lys Glu Leu Gin Thr Gin Ala

210 215 220

Ser Leu Leu Leu Thr Tyr Gin His Leu He Asn Arg Arg Glu Asn Arg 225 230 235 240

Val He Leu Lys Asp Phe Glu Asp Lys Glu Cys Met He Glu He Asp

245 250 255

Lys Ser Met Pro Leu Asn Ala Phe He Asn Lys Lys Phe Thr Leu Ser

260 265 270

Lys Lys Lys Lys Gin Lys Ser Gin Phe Leu Tyr Leu Glu Glu Glu Asn

275 280 285

Leu Lys Glu Lys He Ala Phe Lys Glu Asn Gin He Asn Tyr Val Arg

290 295 300

Asp Ala Ala Glu Glu Ser Val Leu Glu Met Phe Met Pro Val Lys Asn 305 310 315 320

Ser Lys He Lys Arg Pro Met Asn Gly Tyr Glu Val Leu Tyr Tyr Lys

325 330 335

Asp Phe Lys He Gly Leu Gly Lys Asn Gin Lys Glu Asn He Lys Leu

340 345 350

Leu Gin Asp Ala Arg Ala Asn Asp Leu Trp Met His Val Arg Asp He

355 360 365

Pro Gly Ser His Leu He Val Phe Cys Gin Lys Asn Thr Pro Lys Asp

370 375 380

Glu Val He Met Glu Leu Ala Lys Met Leu He Lys Met Gin Lys Asp 385 390 395 400

Ala Phe Asn Gly Tyr Glu He Asp Tyr Thr Gin Arg Lys Phe Val Lys

405 410 415

He He Lys Gly Ala His Val He Tyr Ser Lys Tyr Arg Thr He Ser

420 425 430

Leu Lys Asp Thr 435

(2) INFORMATION FOR SEQ ID NO: 844:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 231 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...231

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 844 :

Met Phe Lys Lys He He Phe Leu Cys Val Phe Leu He Gly Gly Phe

1 5 10 15

Val He Pro Pro Leu Glu Ala Met Pro He Leu Arg Asn Lys Thr Pro

20 25 30

Lys Lys Asn Tyr Gin Glu Ala His Glu Lys Leu Tyr Arg Ser He He

35 40 45

Asn Arg Gin Lys Leu Thr Arg Lys Lys Ser Gly Trp Tyr Phe Leu Gly

50 55 60

Gly Val Gly Ala Val Glu Ala He Lys Asp Tyr Gin Gly Lys Glu Met 65 70 75 80

Lys Asp Trp He Ala Thr Leu Asn Leu Lys Thr Gly Val Gin Ser Phe

85 90 95

Phe Lys Lys Tyr He Gly He Arg Gly Val Phe Ala Trp Asp Leu Gly

100 105 110

Ser Gly Lys Val Asn Tyr Gin Ser Tyr Lys Asp Pro Thr Asn Ser Phe

115 120 125

Phe Thr Met Leu Ala Val Gly Leu Asp Val He Met Glu Phe Pro Leu

130 135 140

Gly Ser Tyr Lys His Tyr Leu Gly Ala Phe Gly Gly Ala Arg Gly Ala 145 150 155 160

Leu Val Val Tyr Thr Asp Lys Gin Asn Phe Lys Phe Phe Lys His Ser

165 170 175

Val Val Ser Gly Gly Leu Ala He Ser Gly Gly Val Met Leu Thr Leu

180 185 190

Phe Leu Arg His Arg He Glu Leu Gly Phe Lys He Leu Pro Thr Ala

195 200 205

Arg Leu Leu Ser Ser Ser Ser Arg Phe Glu Thr Ser Pro Leu Phe Tyr

210 215 220

Ala Ala Tyr Ser Tyr Lys Phe 225 230

(2) INFORMATION FOR SEQ ID NO: 845:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 660 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...660

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 845 :

Met Leu Lys Lys He Phe Tyr Gly Phe He Val Leu Phe Leu He He

1 5 10 15

Val Gly Leu Leu Ala Val Leu Val Ala Gin Val Trp Val Thr Thr Asp

20 25 30

Lys Asp He Ala Lys He Lys Asp Tyr Arg Pro Ser Val Ala Ser Gin

35 40 45

He Leu Asp Arg Lys Gly Arg Leu He Ala Asn He Tyr Asp Lys Glu

50 55 60

Phe Arg Phe Tyr Ala Arg Phe Glu Glu He Pro Pro Arg Phe Val Glu 65 70 75 80

Ser Leu Leu Ala Val Glu Asp Thr Leu Phe Phe Glu His Gly Gly He

85 90 95

Asn Leu Asp Ala Val Met Arg Ala Met He Lys Asn Ala Lys Ser Gly

100 105 110

Arg Tyr Thr Glu Gly Gly Ser Thr Leu Thr Gin Gin Leu Val Lys Asn 115 120 125

Met Val Leu Thr Arg Glu Lys Thr Leu Thr Arg Lys Leu Lys Glu Ala

130 135 140

He He Ser He Arg He Glu Lys Val Leu Ser Lys Glu Glu He Leu 145 150 155 160

Glu Arg Tyr Leu Asn Gin Thr Phe Phe Gly His Gly Tyr Tyr Gly Val

165 170 175

Lys Thr Ala Ser Leu Gly Tyr Phe Lys Lys Pro Leu Asp Lys Leu Thr

180 185 190

Leu Lys Glu He Thr Met Leu Val Ala Leu Pro Arg Ala Pro Ser Phe

195 200 205

Tyr Asp Pro Thr Lys Asn Leu Glu Phe Ser Leu Ser Arg Ala Asn Asp

210 215 220

He Leu Arg Arg Leu Tyr Ser Leu Gly Trp He Ser Ser Asn Glu Leu 225 230 235 240

Lys Ser Ala Leu Asn Glu Val Pro He Val Tyr Asn Gin Thr Ser Thr

245 250 255

Gin Asn He Ala Pro Tyr Val Val Asp Glu Val Leu Lys Gin Leu Asp

260 265 270

Gin Leu Asp Gly Leu Lys Thr Gin Gly Tyr Thr He Lys Leu Thr He

275 280 285

Asp Leu Asp Tyr Gin Arg Leu Ala Leu Glu Ser Leu Arg Phe Gly His

290 295 300

Gin Lys He Leu Glu Lys He Ala Lys Glu Lys Pro Lys Thr Asn Ala 305 310 315 320

Ser Asn Asp Lys Asp Glu Asp Asn Leu Asn Ala Ser Met He Val Thr

325 330 335

Glu Thr Ser Thr Gly Lys He Leu Ala Leu Val Gly Gly He Asp Tyr

340 345 350

Lys Lys Ser Ala Phe Asn Arg Ala Thr Gin Ala Lys Arg Gin Phe Gly

355 360 365

Ser Ala He Lys Pro Phe Val Tyr Gin He Ala Phe Asp Asn Gly Tyr

370 375 380

Ser Thr Thr Ser Lys He Pro Asp Thr Ala Arg Asn Phe Glu Asn Gly 385 390 395 400

Asn Tyr Ser Lys Asn Ser Val Gin Asn His Ala Trp His Pro Ser Asn

405 410 415

Tyr Thr Arg Lys Phe Leu Gly Leu Val Thr Leu Gin Glu Ala Leu Ser

420 425 430

His Ser Leu Asn Leu Ala Thr He Asn Leu Ser Asp Gin Leu Gly Phe

435 440 445

Glu Lys He Tyr Gin Ser Leu Ser Asp Met Gly Phe Lys Asn Leu Pro

450 455 460

Lys Asp Leu Ser He Val Leu Gly Ser Phe Ala He Ser Pro He Asp 465 470 475 480

Ala Ala Glu Lys Tyr Ser Leu Phe Ser Asn Tyr Gly Thr Met Leu Lys

485 490 495

Pro Met Leu He Glu Ser He Thr Asn Gin Gin Asn Glu Val Lys Thr

500 505 510

Phe Thr Pro He Glu Thr Lys Lys He Thr Ser Lys Glu Gin Ala Phe

515 520 525

Leu Thr Leu Ser Ala Leu Met Asp Ala Val Glu Asn Gly Thr Gly Ser

530 535 540

Leu Ala Arg He Lys Gly Leu Glu He Ala Gly Lys Thr Gly Thr Ser 545 550 555 560

Asn Asn Asn He Asp Ala Trp Phe He Gly Phe Thr Pro Thr Leu Gin 565 570 575 Ser Val He Trp Phe Gly Arg Asp Asp Asn Thr Pro He Gly Lys Gly

580 585 590

Ala Thr Gly Gly Val Val Ser Ala Pro Val Tyr Ser Tyr Phe Met Arg

595 600 605

Asn He Leu Ala He Glu Pro Ser Leu Lys Arg Lys Phe Asp Val Pro

610 615 620

Lys Gly Leu Arg Lys Glu He Val Asp Lys He Pro Tyr Tyr Ser Ser 625 630 635 640

Pro Asn Ser He Thr Pro Thr Pro Lys Lys Thr Asp Asp Ser Glu Glu

645 650 655

Arg Leu Leu Phe 660

(2) INFORMATION FOR SEQ ID NO: 846:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 324 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 324

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 846 :

Met Lys Tyr Leu Trp Leu Phe Leu He Tyr Ala He Gly Leu Phe Ala

1 5 10 15

Thr Asp Lys Thr Leu Asp He He Lys Thr He Gin Lys Leu Pro Lys

20 25 30

He Glu Val Arg Tyr Ser He Asp Asn Asp Ala Asn Tyr Ala Leu Lys

35 40 45

Leu His Glu Val Leu Ala Asn Asp Leu Lys Thr Ser Gin His Phe Asp

50 55 60

Val Ser Gin Asn Lys Glu Gin Gly Ala He Asn Tyr Ala Glu Leu Lys 65 70 75 80

Asp Lys Lys Val His Leu Val Ala Leu Val Ser Val Ala Val Glu Asn

85 90 95

Gly Asn Lys He Ser Arg Leu Lys Leu Tyr Asp Val Asp Thr Gly Thr

100 105 110

Leu Lys Lys Thr Phe Asp Tyr Pro He Val Ser Leu Asp Leu Tyr Pro

115 120 125

Phe Ala Ala His Asn Met Ala He Val Val Asn Asp Tyr Leu Lys Ala

130 135 140

Pro Ser He Ala Trp Met Lys Arg Leu He Val Phe Ser Lys Tyr He 145 150 155 160

Gly Pro Gly He Thr Asn He Ala Leu Ala Asp Tyr Thr Met Arg Tyr

165 170 175

Gin Lys Glu He He Lys Asn Asn Arg Leu Asn He Phe Pro Lys Trp 180 185 190 Ala Asn Ala Glu Gin Thr Glu Phe Tyr Tyr Thr Gin Tyr Gly Glu Lys

195 200 205

Thr Pro Met He Leu Lys Tyr Asn He Gin Lys Ala Thr His Glu Asn

210 215 220

He Ala Ser Ser Gin Gly Met Ala Val Val Ser Ser Val Ser Ser Asp 225 230 235 240

Gly Ser Lys He Leu Met Ser Leu Ala Pro Asp Gly Gin Pro Asp Val

245 250 255

Tyr Leu Tyr Asp Thr His Lys Lys Thr Lys Thr Lys He Thr Arg Tyr

260 265 270

Pro Gly He Asp Val Ser Gly Val Phe Leu Glu Asp Asp Lys Ser Met

275 280 285

Ala Phe Val Ser Asp Arg Ser Gly Tyr Pro Asn He Tyr Met Lys Lys

290 295 300

Leu Gly Leu Lys Glu Ser Ala Glu Gin Leu Leu Tyr Glu Gly Arg Ser 305 310 315 320

Asn Glu Ser He

(2) INFORMATION FOR SEQ ID NO: 847:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1288 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 1288

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 847 :

Met Glu He Gin Gin Thr His Arg Lys He Asn Arg Pro Leu Val Ser

1 5 10 15

Leu Val Leu Ala Gly Ala Leu He Ser Ala He Pro Gin Glu Ser His

20 25 30

Ala Ala Phe Phe Thr Thr Val He He Pro Ala He Val Gly Gly He

35 40 45

Ala Thr Gly Thr Ala Val Gly Thr Val Ser Gly Leu Leu Ser Trp Gly

50 55 60

Leu Lys Gin Ala Glu Glu Ala Asn Lys Thr Pro Asp Lys Pro Asp Lys 65 70 75 80

Val Trp Arg He Gin Ala Gly Lys Gly Phe Asn Glu Phe Pro Asn Lys

85 90 95

Glu Tyr Asp Leu Tyr Lys Ser Leu Leu Ser Ser Lys He Asp Gly Gly

100 105 110

Trp Asp Trp Gly Asn Ala Ala Arg His Tyr Trp Val Lys Gly Gly Gin

115 120 125

Trp Asn Lys Leu Glu Val Asp Met Lys Asp Ala Val Gly Thr Tyr Lys 130 135 140 Leu Ser Gly Leu Arg Asn Phe Thr Gly Gly Asp Leu Asp Val Asn Met 145 150 155 160

Gin Lys Ala Thr Leu Arg Leu Gly Gin Phe Asn Gly Asn Ser Phe Thr

165 170 175

Ser Tyr Lys Asp Ser Ala Asp Arg Thr Thr Arg Val Asn Phe Asn Ala

180 185 190

Lys Asn He Ser He Asp Asn Phe Val Glu He Asn Asn Arg Val Gly

195 200 205

Ser Gly Ala Gly Arg Lys Ala Ser Ser Thr Val Leu Thr Leu Gin Ala

210 215 220

Ser Glu Gly He Thr Ser Ser Lys Asn Ala Glu He Ser Leu Tyr Asp 225 230 235 240

Gly Ala Thr Leu Asn Leu Ala Ser Asn Ser Val Lys Leu Asn Gly Asn

245 250 255

Val Trp Met Gly Arg Leu Gin Tyr Val Gly Ala Tyr Leu Ala Pro Ser

260 265 270

Tyr Ser Thr He Asn Thr Ser Lys Val Gin Gly Glu Val Asp Phe Asn

275 280 285

His Leu Thr Val Gly Asp Gin Asn Ala Ala Gin Ala Gly He He Ala

290 295 300

Ser Asn Lys Thr His He Gly Thr Leu Asp Leu Trp Gin Ser Ala Gly 305 310 315 320

Leu Asn He He Ala Pro Pro Glu Gly Gly Tyr Lys Asp Lys Pro Asn

325 330 335

Ser Thr Thr Ser Gin Ser Gly Thr Lys Asn Asp Lys Lys Glu He Ser

340 345 350

Gin Asn Asn Asn Ser Asn Thr Glu Val He Asn Pro Pro Asn Asn Thr

355 360 365

Gin Lys Thr Glu Thr Glu Pro Thr Gin Val He Asp Gly Pro Phe Ala

370 375 380

Gly Gly Lys Asp Thr Val Val Asn He Phe His Leu Asn Thr Lys Ala 385 390 395 400

Asp Gly Thr He Lys Val Gly Gly Phe Lys Ala Ser Leu Thr Thr Asn

405 410 415

Ala Ala His Leu Asn He Gly Lys Gly Gly Val Asn Leu Ser Asn Gin

420 425 430

Ala Ser Gly Arg Thr Leu Leu Val Glu Asn Leu Thr Gly Asn He Thr

435 440 445

Val Asp Gly Pro Leu Arg Val Asn Asn Gin Val Gly Gly Tyr Ala Leu

450 455 460

Ala Gly Ser Ser Ala Asn Phe Glu Phe Lys Ala Gly Val Asp Thr Lys 465 470 475 480

Asn Gly Thr Ala Thr Phe Asn Asn Asp He Ser Leu Gly Arg Phe Val

485 490 495

Asn Leu Lys Val Asp Ala His Thr Ala Asn Phe Lys Gly He Asp Thr

500 505 510

Gly Asn Gly Gly Phe Asn Thr Leu Asp Phe Ser Gly Val Thr Asp Lys

515 520 525

Val Asn He Asn Lys Leu He Thr Ala Ser Thr Asn Val Ala Val Lys

530 535 540

Asn Phe Asn He Asn Glu Leu He Val Lys Thr Asn Gly He Ser Val 545 550 555 560

Gly Glu Tyr Thr His Phe Ser Glu Asp He Gly Ser Gin Ser Arg He

565 570 575

Asn Thr Val Arg Leu Glu Thr Gly Thr Arg Ser He Phe Ser Gly Gly

580 585 590

Val Lys Phe Lys Ser Gly Glu Lys Leu Val He Asn Asp Phe Tyr Tyr 595 600 605

Ser Pro Trp Asn Tyr Phe Asp Ala Arg Asn Val Lys Asn Val Glu He

610 615 620

Thr Arg Lys Phe Ala Ser Ser Thr Pro Glu Asn Pro Trp Gly Thr Ser 625 630 635 640

Lys Leu Met Phe Asn Asn Leu Thr Leu Gly Gin Asn Ala Val Met Asp

645 650 655

Tyr Ser Gin Phe Ser Asn Leu Thr He Gin Gly Asp Phe He Asn Asn

660 665 670

Gin Gly Thr He Asn Tyr Leu Val Arg Gly Gly Lys Val Ala Thr Leu

675 680 685

Asn Val Gly Asn Ala Ala Ala Met Met Phe Asn Asn Asp He Asp Ser

690 695 700

Ala Thr Gly Phe Tyr Lys Pro Leu He Lys He Asn Ser Ala Gin Asp 705 710 715 720

Leu He Lys Asn Thr Glu His Val Leu Leu Lys Ala Lys He He Gly

725 730 735

Tyr Gly Asn Val Ser Thr Gly Thr Asn Gly He Ser Asn Val Asn Leu

740 745 750

Glu Glu Gin Phe Lys Glu Arg Leu Ala Leu Tyr Asn Asn Asn Asn Arg

755 760 765

Met Asp Thr Cys Val Val Arg Asn Thr Asp Asp He Lys Ala Cys Gly

770 775 780

Met Ala He Gly Asn Gin Ser Met Val Asn Asn Pro Asp Asn Tyr Lys 785 790 795 800

Tyr Leu He Gly Lys Ala Trp Arg Asn He Gly He Ser Lys Thr Ala

805 810 815

Asn Gly Ser Lys He Ser Val Tyr Tyr Leu Gly Asn Ser Thr Pro Thr

820 825 830

Glu Asn Gly Gly Asn Thr Thr Asn Leu Pro Thr Asn Thr Thr Asn Asn

835 840 845

Ala His Ser Ala Asn Tyr Ala Leu Val Lys Asn Ala Pro Phe Ala His

850 855 860

Ser Ala Thr Pro Asn Leu Val Ala He Asn Gin His Asp Phe Gly Thr 865 870 875 880

He Glu Ser Val Phe Glu Leu Ala Asn Arg Ser Lys Asp He Asp Thr

885 890 895

Leu Tyr Thr His Ser Gly Ala Gin Gly Arg Asp Leu Leu Gin Thr Leu

900 905 910

Leu He Asp Ser His Asp Ala Gly Tyr Ala Arg Gin Met He Asp Asn

915 920 925

Thr Ser Thr Gly Glu He Thr Lys Gin Leu Asn Ala Ala Thr Asp Ala

930 935 940

Leu Asn Asn Val Ala Ser Leu Glu His Lys Gin Ser Gly Leu Gin Thr 945 950 955 960

Leu Ser Leu Ser Asn Ala Met He Leu Asn Ser Arg Leu Val Asn Leu

965 970 975

Ser Arg Lys His Thr Asn His He Asn Ser Phe Ala Gin Arg Leu Gin

980 985 990

Ala Leu Lys Gly Gin Glu Phe Ala Ser Leu Glu Ser Ala Ala Glu Val

995 1000 1005

Leu Tyr Gin Phe Ala Pro Lys Tyr Glu Lys Pro Thr Asn Val Trp Ala

1010 1015 1020

Asn Ala He Gly Gly Ala Ser Leu Asn Ser Gly Ser Asn Ala Ser Leu 1025 1030 1035 1040

Tyr Gly Thr Ser Ala Gly Val Asp Ala Phe Leu Asn Gly Asn Val Glu 1045 1050 1055 Ala He Val Gly Gly Phe Gly Ser Tyr Gly Tyr Ser Ser Phe Ser Asn

1060 1065 1070

Gin Ala Asn Ser Leu Asn Ser Gly Ala Asn Asn Ala Asn Phe Gly Val

1075 1080 1085

Tyr Ser Arg Phe Phe Ala Asn Gin His Glu Phe Asp Phe Glu Ala Gin

1090 1095 1100

Gly Ala Leu Gly Ser Asp Gin Ser Ser Leu Asn Phe Lys Ser Thr Leu 1105 1110 1115 1120

Leu Gin Asp Leu Asn Gin Ser Tyr Asn Tyr Leu Ala Tyr Ser Ala Thr

1125 1130 1135

Ala Arg Ala Ser Tyr Gly Tyr Asp Phe Ala Phe Phe Arg Asn Ala Leu

1140 1145 1150

Val Leu Lys Pro Ser Val Gly Val Ser Tyr Asn His Leu Gly Ser Thr

1155 1160 1165

Asn Phe Lys Ser Asn Ser Gin Ser Gin Val Ala Leu Lys Asn Gly Ala

1170 1175 1180

Ser Ser Gin His Leu Phe Asn Ala Asn Ala Asn Val Glu Ala Arg Tyr 1185 1190 1195 1200

Tyr Tyr Gly Asp Thr Ser Tyr Phe Tyr Leu His Ala Gly Val Leu Gin

1205 1210 1215

Glu Phe Ala His Phe Gly Ser Asn Asp Val Ala Ser Leu Asn Thr Phe

1220 1225 1230

Lys He Asn Ala Ala Arg Ser Pro Leu Ser Thr Tyr Ala Arg Ala Met

1235 1240 1245

Met Gly Gly Glu Leu Gin Leu Ala Lys Glu Val Phe Leu Asn Leu Gly

1250 1255 1260

Val Val Tyr Leu His Asn Leu He Ser Asn Ala Ser His Phe Ala Ser 1265 1270 1275 1280

Asn Leu Gly Met Arg Tyr Ser Phe 1285

(2) INFORMATION FOR SEQ ID NO: 848:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 385 am o acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...385

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 848:

Met Lys Asp Ser Phe Leu Phe Thr Ser Glu Ser Val Thr Glu Gly His

1 5 10 15

Pro Asp Lys Met Ala Asp Gin He Ser Asp Ala Val Leu Asp Tyr He

20 25 30

He Glu Arg Asp Lys Lys Ala Lys Val Ala Cys Glu Thr Leu Val Ser 35 40 45 Asn Gly Phe Cys Met He Thr Gly Glu Leu Lys Thr Ser Val Tyr Ala

50 55 60

Pro Met Gin Glu He Ala Arg Glu Val Val Lys Lys He Gly Tyr Thr 65 70 75 80

Asp Ala Leu Tyr Gly Phe Asp Tyr Arg Ser Ala Ala Val Leu Asn Gly

85 90 95

He Gly Glu Gin Ser Pro Asp He Asn Gin Gly Val Asp Arg Glu Asp

100 105 110

Gly Glu He Gly Ala Gly Asp Gin Gly Leu Met Phe Gly Tyr Ala Cys

115 120 125

Lys Glu Thr Glu Thr Leu Met Pro Leu Pro He His Leu Ala His Gin

130 135 140

Leu Ala Phe Ala Leu Ala Gin Lys Arg Lys Asp Asn Thr Leu Pro Phe 145 150 155 160

Leu Arg Pro Asp Gly Lys Ser Gin Val Ser Val Arg Tyr Glu Asn Asn

165 170 175

Lys Pro Val Ser Val Asp Thr He Val He Ser Thr Gin His Ser Pro

180 185 190

Glu Val Ser Gin Lys His Leu Lys Glu Ala Val He Glu Glu He Val

195 200 205

Tyr Lys Val Leu Pro Lys Glu Tyr Leu His Asp Asn He Lys Phe Phe

210 215 220

He Asn Pro Thr Gly Lys Phe Val He Gly Gly Pro Gin Gly Asp Ala 225 230 235 240

Gly Leu Thr Gly Arg Lys He He Val Asp Thr Tyr Gly Gly Phe Cys

245 250 255

Pro His Gly Gly Gly Ala Phe Ser Gly Lys Asp Pro Ser Lys Val Asp

260 265 270

Arg Ser Ala Ala Tyr Ala Ala Arg Tyr Val Ala Lys Asn Leu Val Ala

275 280 285

Ser Gly Val Cys Asp Lys Ala Thr Val Gin Leu Ala Tyr Ala He Gly

290 295 300

Val He Glu Pro Val Ser He Tyr Val Asn Thr His Asn Thr Ser Lys 305 310 315 320

His Ser Ser Ala Glu Leu Glu Lys Cys Val Lys Ser Val Phe Lys Leu

325 330 335

Thr Pro Lys Gly He He Glu Ser Leu Asp Leu Leu Arg Pro He Tyr

340 345 350

Ser Leu Thr Ser Ala Tyr Gly His Phe Gly Arg Glu Leu Glu Glu Phe

355 360 365

Thr Trp Glu Lys Thr Asn Lys Val Glu Glu He Lys Ala Phe Phe Lys

370 375 380

Arg 385

(2) INFORMATION FOR SEQ ID NO: 849:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 68 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE: (A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...68

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 849:

Met Lys Phe Leu Asn Gly Leu Ala Gly Asn Leu Leu He Val Val He

1 5 10 15

Leu Leu Cys Val Val Val Phe Phe Ala Leu Lys Ala He His He Gin

20 25 30

Lys Glu Gin Ala Thr Asn Tyr Tyr Arg Tyr Lys Asp He Asn Ala Leu

35 40 45

Glu Ala Lys Asn Thr Gin Asn His Ala Asn Tyr Glu Leu Val Asn Gin

50 55 60

Gly Ser Lys Lys 65

(2) INFORMATION FOR SEQ ID NO: 850:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 502 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...502

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 850:

Leu Lys He Phe Leu Val He Leu Ser Val Phe Phe Phe Asn Gly Cys

1 5 10 15

Phe Gly Leu Val Tyr Lys Thr Pro He Ser Asn Pro Pro He Ser Tyr

20 25 30

Asp Pro Tyr Thr Thr Thr He Gly Ser Leu Tyr Ala Lys Asn Leu Lys

35 40 45

Glu Asn Pro Lys His Ser Ala Ala He Leu Leu Glu Asp Gly Phe Asp

50 55 60

Ala Leu Leu His Arg Val Gly Leu He Arg Met Ser Gin Lys Ser He 65 70 75 80

Asp Met Gin Thr Tyr He Tyr Lys Asn Asp Leu Ser Ser Gin Val He

85 90 95

Ala Lys Glu Leu Leu Asn Ala Ala Asn Arg Gly Val Lys Val Arg He

100 105 110

Leu Leu Asp Asp Asn Gly Leu Asp Ser Asp Phe Ser Asp He Met Leu

115 120 125

Leu Asn Phe His Lys Asn He Glu Val Lys He Phe Asn Pro Tyr Tyr 130 135 140 He Arg Asn Lys Gly Leu Arg Tyr Phe Glu Met Leu Ala Asp Tyr Glu 145 150 155 160

Arg He Lys Lys Arg Met His Asn Lys Leu Phe He Val Asp Asn Phe

165 170 175

Ala Val He He Gly Gly Arg Asn He Gly Asp Asn Tyr Phe Asp Asn

180 185 190

Asp Leu Asp Thr Asn Phe Leu Asp Leu Asp Ala Leu Phe Phe Gly Gly

195 200 205

Val Ala Ser Lys Ala Lys Glu Ser Phe Glu Asn Tyr Trp Arg Phe His

210 215 220

Arg Ser He Pro Val Ser Leu Leu Arg Thr His Lys Arg Leu Lys Asn 225 230 235 240

Asn Val Lys Glu He Ala Lys Leu His Glu Lys He Pro He Ser Ala

245 250 255

Glu Asp Ala Asn Glu Phe Glu Lys Lys Val Asn Asp Phe He Glu Arg

260 265 270

Phe Gin Lys Tyr Gin Tyr Pro He Tyr Tyr Gly Asn Ala He Phe Leu

275 280 285

Ala Asp Leu Pro Ala Lys He Asp Thr Pro Leu Tyr Ser Pro He Lys

290 295 300

He Ala Phe Glu Lys Ala Leu Lys Asn Ala Lys Asp Ser Val Phe He 305 310 315 320

Ala Ser Ser Tyr Phe He Pro Gly Lys Lys He Met Lys He Phe Lys

325 330 335

Asn Gin He Ser Lys Gly He Glu Leu Asn He Leu Thr Asn Ser Leu

340 345 350

Ser Ser Thr Asp Ala He Val Val Tyr Gly Ala Trp Glu Arg Tyr Arg

355 360 365

Asn Lys Leu Val Arg Met Gly Ala Asn Val Tyr Glu He Arg Asn Asp

370 375 380

Phe Phe Asn Arg Gin He Lys Gly Arg Phe Ser Thr Lys His Ser Leu 385 390 395 400

His Gly Lys Thr He Val Phe Asp Asp Ala Leu Thr Leu Leu Gly Ser

405 410 415

Phe Asn He Asp Pro Arg Ser Ala Tyr He Asn Thr Glu Ser Ala Val

420 425 430

Leu Phe Asp Asn Pro Ser Phe Ala Lys Arg Val Arg Leu Ser Leu Lys

435 440 445

Asp His Ala Gin Gin Ser Trp His Leu Val Leu Tyr Arg His Arg Val

450 455 460

He Trp Glu Ala Thr Glu Glu Gly He Leu He His Glu Lys Asn Ser 465 470 475 480

Pro Asp Thr Ser Phe Phe Leu Arg Leu He Lys Glu Trp Ser Lys Val

485 490 495

Leu Pro Glu Arg Glu Leu 500

(2) INFORMATION FOR SEQ ID NO: 851:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 177 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...177

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 851 :

Met Arg Phe Ser Tyr He Glu Pro Arg Ala Lys Tyr Leu He Ser Lys

1 5 10 15

Leu Ser Lys He Trp Val Phe Tyr He Phe Leu Ser Phe Val Leu He

20 25 30

Gly Gly Leu Val Trp Phe Met His Asn Ala He Lys Arg Ala Gin Asp

35 40 45

Asn Ala Ser Ser Leu Thr He Gin Glu Arg Leu Tyr Arg His Glu He

50 55 60

Ser Arg Leu Gin Val Lys Thr Asp Glu Thr Leu Lys Leu He Lys Glu 65 70 75 80

Ala Lys Lys Arg Leu Asn Tyr Asn Asp Asp He Arg Asp Val Leu Gin

85 90 95

Gly Leu Leu Asn He Val Pro Asp Leu He Thr He Asn Ser He Glu

100 105 110

He Asp Gin Gin Ser Val Val Val Ser Gly Lys Thr Pro Ser Lys Glu

115 120 125

Ala Phe Tyr Phe Leu Phe Gin Asn Lys Leu Asn Pro Met Phe Asp Tyr

130 135 140

Ser Arg Ala Glu Phe Phe Pro Leu Ser Asp Gly Trp Phe Asn Phe Val 145 150 155 160

Ser Thr Asn Phe Ser Asn Ser Leu Leu He Lys Asn Pro Glu Ser He

165 170 175

Lys

(2) INFORMATION FOR SEQ ID NO: 852:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 222 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 222

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 852:

Met Arg Lys He Leu Leu Met Gly Leu He Leu Gin Ala Leu Phe Gly 1 5 10 15 Glu Glu Ala Ala Gin Glu Leu Leu Gin Cys Ser Ala He Phe Glu Ser

20 25 30

Lys Lys Ala Glu Leu Lys Glu Asp Leu Arg Gin Leu Ser Glu Lys Glu

35 40 45

Gin Ser Leu Arg He Leu Gin Thr Glu Asn Ala Arg Leu Leu Asp Glu

50 55 60

Lys Ser Asp Leu Leu Asn Lys Lys Glu Lys Glu He Asp Glu Lys Leu 65 70 75 80

Lys Asn Leu Ala Ala Lys Glu Glu Ala Phe Lys Thr Leu Gin Thr Glu

85 90 95

Glu Lys Lys Arg Leu Lys Asn Leu He Glu Glu Asn Glu Gly He Leu

100 105 110

Arg Glu He Lys Gin Ala Lys Asp Ser Lys He Gly Glu Thr Tyr Ser

115 120 125

Lys Met Lys Asp Ser Lys Ser Ala Leu He Leu Glu Asn Leu Pro Thr

130 135 140

Gin Asn Ala Leu Glu He Leu Met Ala Leu Lys Pro Gin Glu Leu Gly 145 150 155 160

Lys He Leu Ala Lys Met Asp Pro Lys Lys Ala Ala Ala Leu Thr Glu

165 170 175

Leu Trp Gin Lys Pro Pro Lys Glu Asn Lys Glu Asn Lys Glu Ser Gin

180 185 190

Lys Thr Thr Asp Pro Thr Pro Pro Thr Pro Pro Thr Pro Pro Lys Glu

195 200 205

Pro Thr Leu Lys Asp Pro Asn Val Lys Glu Pro Thr Gly Val 210 215 220

(2) INFORMATION FOR SEQ ID NO: 853:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 431 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein-

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...431

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 853 :

Met Asn He Gin Thr Lys Lys Arg Phe Leu Ala Asn Leu Leu Leu Phe

1 5 10 15

Ser Leu Phe Ser Cys Leu Lys Ala Glu Thr Leu Ser Glu Asp His Gin

20 25 30

He Leu Leu Ser Ser Asp Ala Phe His Arg Gly Asp Phe Ala Thr Ala

35 40 45

Gin Lys Gly Tyr Met Asn Leu Tyr Lys Gin Thr Asn Lys Val Val Tyr

50 55 60

Ala Lys Glu Ala Ala He Ser Ala Ala Ser Leu Gly Asp He Lys Thr 65 70 75 80 Ala Met His Leu Ala Met Leu Tyr Gin Lys He Thr Asn Asn Arg Asn

85 90 95

Asp Val Ser He Asn Lys He Leu Val Asp Gly Tyr Ala Gin Met Gly

100 105 110

Gin He Asp Lys Ala He Glu Leu Leu His Lys He Arg Lys Glu Glu

115 120 125

Lys Thr He Ala Thr Asp Asn Val Leu Gly Thr Leu Tyr Leu Thr Gin

130 135 140

Lys Arg Leu Asp Lys Ala Phe Pro Leu Leu Asn Lys Phe Tyr Asn Gin 145 150 155 160

Val His Asp Glu Asp Ser Leu Glu Lys Leu He Thr He Tyr Phe Leu

165 170 175

Gin Asn Arg Lys Lys Glu Gly Leu Asp Leu Leu Gin Ser His He Asp

180 185 190

Arg Tyr Gly Cys Ser Glu Gin Leu Cys Gin Lys Ala Leu Asn Thr Phe

195 200 205

Thr Gin Phe Asn Glu Leu Asp Leu Ala Lys Thr Thr Phe Ala Arg Leu

210 215 220

Tyr Glu Lys Asn Pro He Val Gin Asn Ala Gin Phe Tyr He Gly Val 225 230 235 240

Leu He Leu Leu Lys Glu Phe Asp Lys Ala Gin Gin He Ala Glu Leu

245 250 255

Phe Pro Phe Asp Arg Arg Leu Leu Leu Asp Leu Tyr Thr Ala Gin Lys

260 265 270

Lys Phe Asp Gin Ala Ser Lys Gin Ala Ser Leu He Tyr Gin Glu Arg

275 280 285

Lys Asp Pro Lys Phe Leu Gly Leu Glu Ala He Tyr His Tyr Glu Ser

290 295 300

Leu Ser Ala Asn Lys Lys Lys Leu Thr Lys Glu Glu Met Leu Pro He 305 310 315 320

He Gin Lys Leu Glu Gin Ala Thr Lys Glu Arg Gin Ala Trp Leu Ala

325 330 335

Lys Thr Lys Asp Lys Glu Asp Ala Gin Asp Ala Phe Phe Tyr Asn Phe

340 345 350

Leu Gly Tyr Ser Leu He Asp Tyr Asp Met Asp Val Lys Arg Gly Met

355 360 365

Asp Leu Val Arg Lys Ala Leu Ala Leu Asp Ser Asn Ser Val Leu Tyr

370 375 380

Leu Asp Ser Leu Ala Trp Gly Tyr Tyr Lys Leu Gly Asn Cys Leu Glu 385 390 395 400

Ala Lys Lys He Phe Ser Ser He Ala Lys Glu Leu He Gin Asn Glu

405 410 415

Pro Glu Leu Lys Glu His Asn Lys He He Gin Glu Cys Lys Lys 420 425 430

(2) INFORMATION FOR SEQ ID NO: 854:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 97 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE: (A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...97

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 854:

Met Leu Tyr Ala Ser Lys Ala Arg Leu Phe Leu Gin He Lys Gly Lys

1 5 10 15

Phe Met Leu Arg He Leu He Pro Leu Leu He He Val Trp Val Leu

20 25 30

Trp Arg Leu Phe Leu Arg Gin Lys Pro His Lys Asp Asp His Arg Asp

35 40 45

Asn His Ser Tyr Thr Gin Gin Thr Pro Lys Glu Leu Glu Asp His Met

50 55 60

He Val Cys Ser Lys Cys Gin Thr Tyr Val Ser Ser Lys Asp Ala He 65 70 75 80

Tyr Ser Gly Ala Val Ala Tyr Cys Ser Glu Thr Cys Leu Lys Asp Lys

85 90 95

Gly

(2) INFORMATION FOR SEQ ID NO: 855:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 479 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...479

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 855:

Met Lys Asn Ser Ala Pro Leu Lys Asn Lys Val Phe Cys Gly Leu Tyr

1 5 10 15

Val Leu Ser Leu Ser Ala Ser Val Gin Ala Phe Asp Tyr Lys He Glu

20 25 30

Val Leu Ala Glu Ser Phe Ser Lys Val Gly Phe Asn Lys Lys Lys He

35 40 45

Asp He Ala Arg Gly He Tyr Pro Thr Glu Thr Phe Val Thr Ala Val

50 55 60

Gly Gin Gly Asn He Tyr Ala Asp Phe Leu Ser Lys Ser Leu Lys Asp 65 70 75 80

Gin Gly His Val Leu Glu Gly Lys Val Gly Gly Thr He Gly Gly He

85 90 95

Ala Tyr Asp Ser Thr Lys Phe Asn Gin Gly Gly Ser Val He Tyr Asn 100 105 110 Tyr He Gly Tyr Trp Asp Gly Tyr Leu Gly Gly Lys Arg Ala Leu Leu

115 120 125

Asp Gly Thr Ser He His Glu Cys Ala Leu Gly Ser Asp Gly Lys Val

130 135 140

He Asp Ser He Ala Cys Gly Asn Ala Arg Ala Asn Lys He Arg Arg 145 150 155 160

Asn Tyr Leu Met Asn Asn Ala Phe Leu Glu Tyr Arg Tyr Lys Asp He

165 170 175

Phe Ala Ala Lys Gly Gly Arg Tyr Gin Ser Asn Ala Pro Tyr Met Ser

180 185 190

Ser Tyr Thr Gin Gly Phe Glu He Ser Ala Lys He Lys Asp Lys Asn

195 200 205

Glu Gly Ser His Lys Leu Trp Trp Phe Ser Ser Trp Gly Arg Ala Phe

210 215 220

Ala Tyr Gly Glu Trp He Tyr Asp Phe Tyr Ser Pro Arg Thr Val He 225 230 235 240

Lys Asn Gly Arg Thr Leu Asn Tyr Gly He His Leu Val Asp Tyr Thr

245 250 255

Tyr Glu Arg Lys Gly Val Ser Val Ser Pro Phe Phe Gin Phe Ser Pro

260 265 270

Gly Thr Tyr Tyr Ser Pro Gly Val Ala Val Gly Tyr Asp Ser Asn Pro

275 280 285

Asn Phe Asn Gly Val Gly Phe Arg Ser Glu Thr Lys Ala Tyr He Leu

290 295 300

Leu Pro Val His Ala Pro Leu Lys Arg Asp Thr Tyr Arg Tyr Ala Val 305 310 315 320

Lys Ala Gly Thr Ala Gly Gin Ser Leu Leu He Arg Gin Arg Phe Asp

325 330 335

Tyr Asn Glu Phe Asn Phe Gly Gly Ala Phe Tyr Lys Val Trp Lys Asn

340 345 350

Ala Asn Ala Tyr He Gly Thr Thr Gly Asn Pro Leu Gly He Asp Phe

355 360 365

Trp Thr Asn Ser Val Tyr Asp He Gly Gin Ala Leu Ser His Val Val

370 375 380

Thr Ala Asp Ala Val Ser Gly Trp Val Phe Gly Gly Gly Val His Lys 385 390 395 400

Lys Trp Leu Trp Gly Thr Leu Trp Arg Trp Thr Ser Gly Ala Leu Ala

405 410 415

Asn Glu Ala Ser Ala Ala Val Asn Val Gly Tyr Lys He Ser Lys Ser

420 425 430

Leu Thr Ala Ser Val Lys Leu Glu Tyr Leu Gly Val Met Thr His Ser

435 440 445

Gly Phe Thr Val Gly Ser Tyr Arg Pro Thr Pro Gly Ser Lys Ala Leu

450 455 460

Tyr Ser Asp Arg Ser His Leu Met Thr Thr Leu Ser Ala Lys Phe 465 470 475

(2) INFORMATION FOR SEQ ID NO: 856:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 479 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...479

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 856:

Met Lys Asn Ser Ala Pro Leu Lys Asn Lys Val Phe Cys Gly Leu Tyr

1 5 10 15

Val Leu Ser Leu Ser Ala Ser Val Gin Ala Phe Asp Tyr Lys He Glu

20 25 30

Val Leu Ala Glu Ser Phe Ser Lys Val Gly Phe Asn Lys Lys Lys He

35 40 45

Asp He Ala Arg Gly He Tyr Pro Thr Glu Thr Phe Val Thr Ala Val

50 55 60

Gly Gin Gly Asn He Tyr Ala Asp Phe Leu Ser Lys Ser Leu Lys Asp 65 70 75 80

Gin Gly His Val Leu Glu Gly Lys Val Gly Gly Thr He Gly Gly He

85 90 95

Ala Tyr Asp Ser Thr Lys Phe Asn Gin Gly Gly Ser Val He Tyr Asn

100 105 110

Tyr He Gly Tyr Trp Asp Gly Tyr Leu Gly Gly Lys Arg Ala Leu Leu

115 120 125

Asp Gly Thr Ser He His Glu Cys Ala Leu Gly Ser Asp Gly Lys Val

130 135 140

He Asp Ser He Ala Cys Gly Asn Ala Arg Ala Asn Lys He Arg Arg 145 150 155 160

Asn Tyr Leu Met Asn Asn Ala Phe Leu Glu Tyr Arg Tyr Lys Asp He

165 170 175

Phe Ala Ala Lys Gly Gly Arg Tyr Gin Ser Asn Ala Pro Tyr Met Ser

180 185 190

Ser Tyr Thr Gin Gly Phe Glu He Ser Ala Lys He Lys Asp Lys Asn

195 200 205

Glu Gly Ser His Lys Leu Trp Trp Phe Ser Ser Trp Gly Arg Ala Phe

210 215 220

Ala Tyr Gly Glu Trp He Tyr Asp Phe Tyr Ser Pro Arg Thr Val He 225 230 235 240

Lys Asn Gly Arg Thr Leu Asn Tyr Gly He His Leu Val Asp Tyr Thr

245 250 255

Tyr Glu Arg Lys Gly Val Ser Val Ser Pro Phe Phe Gin Phe Ser Pro

260 265 270

Gly Thr Tyr Tyr Ser Pro Gly Val Ala Val Gly Tyr Asp Ser Asn Pro

275 280 285

Asn Phe Asn Gly Val Gly Phe Arg Ser Glu Thr Lys Ala Tyr He Leu

290 295 300

Leu Pro Val His Ala Pro Leu Lys Arg Asp Thr Tyr Arg Tyr Ala Val 305 310 315 320

Lys Ala Gly Thr Ala Gly Gin Ser Leu Leu He Arg Gin Arg Phe Asp

325 330 335

Tyr Asn Glu Phe Asn Phe Gly Gly Ala Phe Tyr Lys Val Trp Lys Asn

340 345 350

Ala Asn Ala Tyr He Gly Thr Thr Gly Asn Pro Leu Gly He Asp Phe

355 360 365

Trp Thr Asn Ser Val Tyr Asp He Gly Gin Ala Leu Ser His Val Val 370 375 380

Thr Ala Asp Ala Val Ser Gly Trp Val Phe Gly Gly Gly Val His Lys 385 390 395 400

Lys Trp Leu Trp Gly Thr Leu Trp Arg Trp Thr Ser Gly Ala Leu Ala

405 410 415

Asn Glu Ala Ser Ala Ala Val Asn Val Gly Tyr Lys He Ser Lys Ser

420 425 430

Leu Thr Ala Ser Val Lys Leu Glu Tyr Leu Gly Val Met Thr His Ser

435 440 445

Gly Phe Thr Val Gly Ser Tyr Arg Pro Thr Pro Gly Ser Lys Ala Leu

450 455 460

Tyr Ser Asp Arg Ser His Leu Met Thr Thr Leu Ser Ala Lys Phe 465 470 475

(2) INFORMATION FOR SEQ ID NO: 857:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 171 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...171

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 857:

Met Gly Leu Lys Asn Leu Ser Thr Leu Leu Val Phe Leu Phe Phe Cys

1 5 10 15

Leu Gly Cys Val Ser Asn Phe Asn Glu Asp Thr Tyr Thr Leu Asp Leu

20 25 30

Val Leu Glu Lys Lys He Gin Ala Ser Arg Lys Gly Glu He Thr Gin

35 40 45

Asp Asn Val Pro He He Thr Ala He Ala Thr His Leu Asn Asp Val

50 55 60

Asp Ser Gly Thr Tyr Tyr Asp His Glu Tyr Phe Leu Val Glu He Phe 65 70 75 80

Thr Gin Asn Asn Asp Trp He Asp Asp Gly Tyr He Ser Tyr Glu Leu

85 90 95

Phe Gly Thr Lys Pro Thr Gly Ser Glu Pro Leu Trp Val Arg Glu He

100 105 110

Thr Arg Asp Glu Phe Asp Gly He Leu Glu Thr Thr Asn Arg Trp Ser

115 120 125

Arg Ala Phe Leu He Ala Phe Asp Lys Leu Asp Tyr Leu Ala Val Gin

130 135 140

Glu Ala Lys Leu Glu Leu Asp Ala Tyr Ser Leu Gly Lys He Val Phe 145 150 155 160

Asn Phe Ala Tyr Gin Val Pro Leu Pro Gin Phe 165 170 (2) INFORMATION FOR SEQ ID NO: 858:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 84 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...84

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 858 :

Val Asn Lys Lys His Arg Leu Ala Phe Leu Gly Leu He Val Gly Val

1 5 10 15

Leu Phe Phe Phe Ser Ala Cys Gin His Arg Leu His Met Gly Tyr Tyr

20 25 30

Ser Glu Val Thr Gly Asp Tyr Leu Phe Asn Tyr Asn Ser Thr He Val

35 40 45

Val Ala Tyr Asp Arg Ser Asp Ala Met Thr Ser Tyr Tyr He Asn Val

50 55 60

He Val Tyr Glu Leu Gin Lys Leu Gly Phe Tyr Asn Val Phe Thr Gin 65 70 75 80

Ala Asn Ser Arg

(2) INFORMATION FOR SEQ ID NO: 859:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 252 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...252

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 859:

Met Gin Tyr Lys Lys Asn Lys Lys Arg Tyr Tyr His Leu Ala Leu Gly 1 5 10 15

He Leu Phe Cys Asn Gly Leu Ser Leu Lys Ala Leu Glu He Ala Val 20 25 30 Lys Pro Phe Gly Tyr Leu Gly Leu Leu Tyr Asn Gin Gly Thr Gin Lys

35 40 45

Asn Pro His Ser Tyr Val Gly Ala Leu Ala Arg Leu Gly Val Asp Phe

50 55 60

Ser Tyr Ser Asn Gly Trp Ser Phe Gly He Gly Ala He Gly Ala Trp 65 70 75 80

Asn He Tyr Asn Lys Gin Arg Leu Ala Asn Leu Tyr He Ser Leu Gly

85 90 95

Asn Phe Phe Gly Asn Pro Asn Asn Val Lys Pro Tyr Leu Ser Ala Gly

100 105 110

Asp Val Ser Asp Ala Tyr Leu Gin Tyr Ala Asn Gin Arg Phe Lys He

115 120 125

Ala Leu Gly Arg Phe Asn Thr Asp Phe Val Asp Phe Asp Trp He Gly

130 135 140

Gly Asn He Gin Gly Val Ser Val Ala Phe Lys Gin Asn Ser Met Arg 145 150 155 160

Tyr Phe Gly He Phe Met Asp Ser Met Leu Tyr Asn Gly His Gin He

165 170 175

Asn Lys Glu Gin Gly Asn Arg He Ala Thr Ser Leu Asn Ala Leu Ala

180 185 190

Ser Tyr Asp Pro Val Ser Lys Arg Leu Tyr Val Gly Gly Glu Val Phe

195 200 205

Val Leu Gly Ala Glu Tyr Lys Asn Lys Asn Leu He Phe Val Pro Phe

210 215 220

He Leu Thr Asp Thr Arg Leu Pro Leu Pro Thr Gin Asn Val Leu Val 225 230 235 240

Gin Val Gly Gly Lys Leu Glu Tyr Arg Arg Phe Phe 245 250

(2) INFORMATION FOR SEQ ID NO: 860:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 231 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...231

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 860 :

Met Val Gin Lys He Gly He Leu Gly Ala Met Arg Glu Glu He Thr

1 5 10 15

Pro He Leu Glu Leu Phe Gly Val Asp Phe Glu Glu He Pro Leu Gly

20 25 30

Gly Asn Val Phe His Lys Gly Val Tyr His Asn Lys Glu He He Val

35 40 45

Ala Tyr Ser Lys He Gly Lys Val His Ser Thr Leu Thr Thr Thr Ser 50 55 60 Met He Leu Ala Phe Gly Val Gin Lys Val Leu Phe Ser Gly Val Ala 65 70 75 80

Gly Ser Leu Val Lys Asp Leu Lys He Asn Asp Leu Leu Val Ala Thr

85 90 95

Gin Leu Val Gin His Asp Val Asp Leu Ser Ala Phe Asp His Pro Leu

100 105 110

Gly Phe He Pro Glu Ser Ala He Phe He Glu Thr Ser Gly Ser Leu

115 120 125

Asn Ala Leu Ala Lys Lys He Ala Asn Glu Gin His He Ala Leu Lys

130 135 140

Glu Gly Val He Ala Ser Gly Asp Gin Phe Val His Ser Lys Glu Arg 145 150 155 160

Lys Glu Phe Leu Val Ser Glu Phe Lys Ala Ser Ala Val Glu Met Glu

165 170 175

Gly Ala Ser Val Ala Phe Val Cys Gin Lys Phe Gly Val Pro Cys Cys

180 185 190

Val Leu Arg Ser He Ser Asp Asn Ala Asp Glu Lys Ala Gly Met Ser

195 200 205

Phe Asp Glu Phe Leu Glu Lys Ser Ala His Thr Ser Ala Lys Phe Leu

210 215 220

Lys Ser Met Val Asp Glu Leu 225 230

(2) INFORMATION FOR SEQ ID NO: 861:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 225 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A ) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 225

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 861 :

Met Arg Ala Thr Ala He Lys He Phe Ser Phe Ser Ser Ala Leu Ala

1 5 10 15

Leu Leu Leu Gin Gly Cys Leu Ser He Asn Leu Lys Gin Met Leu Pro

20 25 30

Glu He Arg Thr Tyr Asp Leu Asn Ala Ser Ser Phe Glu Met Thr Gin

35 40 45

Cys Pro Lys Pro Leu Thr Glu Val Arg Leu He Ser He Leu Ser Ala

50 55 60

Asp Leu Phe Asn Thr Lys Glu He Val Phe Lys Ala Gin Asp Gly Gin 65 70 75 80

He Thr His Gly Lys His Gin Lys Trp He Asp Leu Pro Arg Asn Met

85 90 95

Leu Lys Thr Met Phe Met Gin Glu Ala Gin Lys Ala Cys Leu Gly Val 100 105 110 Ala Leu Pro Pro Tyr Gly Ala Gly Ala Pro Thr Tyr Ala Val Arg Phe

115 120 125

Thr He Leu Ser Phe Ser Leu Leu Glu Lys Glu Asn Ser Thr Tyr Arg

130 135 140

Ala Glu Phe Ala Leu Gly Tyr Asp He Ser Val Lys Gly Asp Ser His 145 150 155 160

Ser Gly Val He He Lys His Glu Asn He Ser Ser Leu Glu Asn Lys

165 170 175

Thr Thr Lys Thr Ser Lys Asn Gly Ser Gin Asp Phe Gin Glu Ser Ala

180 185 190

He Gin Ser Leu Gin His Val Ser Thr Gin Ala Met Gin Glu Ala He

195 200 205

Ser Leu He Lys Lys Ala Val Glu Ala Gin Ser Val Ser Pro Leu Lys

210 215 220

Lys 225

(2) INFORMATION FOR SEQ ID NO: 862:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 271 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...271

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 862 :

Leu Glu Arg His Val Asn Tyr Thr Leu He Gly Gly Leu Phe Phe Leu

1 5 10 15

Cys Leu Val Cys Met Val Gly Phe He Leu Trp Leu Gly His Leu Gly

20 25 30

Leu Asp Asp Gly Lys Tyr Tyr Glu Tyr Val Val Tyr Thr Asp Lys Asp

35 40 45

Leu Gly Gly He Ala Thr Asn Ser Pro He Asn Tyr Lys Gly He Gin

50 55 60

Val Gly Asn Val He Lys Val Gly Phe Ala Lys Asp Lys Val Gly Val 65 70 75 80

Val Arg Leu Asp Leu Met He Lys Ser Ser Val Lys He Arg Lys Asp

85 90 95

Ser Lys Val Ala Val Ser Ser Arg Gly Phe Met Gly Leu Lys Phe Leu

100 105 110

Ala Leu Glu Gin Ser His Asn Glu Glu Phe Tyr Gly Ser Gly Asp Lys

115 120 125

Gly Glu Arg He Leu He Phe Lys Glu Gly Leu Met Asp Arg Leu Ser

130 135 140

Gly Asp Ala Asn Gin Val Val Gin Glu Val Met Lys Ala He Arg Asn 145 150 155 160 Val Asn Arg He Leu Asp Asp Glu Asn Val Glu Lys Phe Lys His He

165 170 175

Leu Ala Ser Val Asp Asp Leu He Ala Asn Leu Asp Ser Arg Lys Thr

180 185 190

Gin Phe Asp Ser Leu He Asn Asn Ala Asn Asn Leu Val Ser Asn Val

195 200 205

Asn Asn Val Ala Leu Asp Val Asp Lys Arg Val Lys Gin Gly Gin Tyr

210 215 220

Asp Phe Lys Ala Met Phe Thr Pro Leu He Met Gin Ala Gin Leu Ser 225 230 235 240

Leu Arg Asn He Asp Asn Phe Val Glu Lys Gly Ser Ala Leu He Asp

245 250 255

Lys Phe Asp Ala Asn Pro Tyr Lys Thr He Phe Gly Glu Arg Lys 260 265 270

(2) INFORMATION FOR SEQ ID NO: 863:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 350 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...350

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 863 :

Met Lys Lys Thr He Leu Leu Ser Ala Leu Leu Ala Phe Ser Cys Ala

1 5 10 15

His Ala Leu Ser Asp Met Asp Leu He Lys Lys Ala Lys Glu Ser Gin

20 25 30

Leu Glu Pro Met Pro Met Gly Lys Ala Leu Lys Glu Tyr Gin He Lys

35 40 45

Lys Thr Arg Asp Val Gly He Gly Ala Lys Asn Ser Glu He Met Thr

50 55 60

Ser Ala Gin Val Glu Leu Gly Lys Met Leu Tyr Phe Asp Pro Arg He 65 70 75 80

Ser Thr Ser Tyr Leu Val Ser Cys Asn Thr Cys His Asn Leu Gly Leu

85 90 95

Gly Gly Val Asp Leu He Pro Ser Ala He Gly Ser Gin Trp Lys Lys

100 105 110

Asn Pro His Leu Leu Ser Ser Pro Thr Val Tyr Asn Ser Val Phe Asn

115 120 125

Asp Val Gin Phe Trp Asp Gly Arg Val Thr His Leu Asn Glu Gin Ala

130 135 140

Gin Gly Pro He Gin Ser Ser Phe Glu Met Gly Ala Asp Pro Lys Val 145 150 155 160

Val Val Glu Lys He Asn Ser He Pro Gly Tyr Val Lys Leu Phe Arg 165 170 175 Lys Ala Tyr Gly Ser Lys Val Lys He Asp Phe Lys Leu He Ala Asp

180 185 190

Ser He Ala Met Pne Glu Ala Thr Leu He Thr Pro Ser Arg Tyr Asp

195 200 205

Asp Phe Leu Arg Gly Asn Pro Lys Ala Leu Ser Lys Ala Glu Lys Glu

210 215 220

Gly Leu Asp Leu Phe He Ser Lys Gly Cys Val Ala Cys His Asn Gly 225 230 235 240

He Asn Leu Gly Gly Thr Met Gin Pro Phe Gly Val Val Lys Pro Tyr

245 250 255

Lys Phe Ala Asn Val Gly Asp Phe Lys Gly Asp Lys Asn Gly Leu Val

260 265 270

Lys Val Pro Thr Leu Arg Asn He Thr Glu Thr Met Pro Tyr Phe His

275 280 285

Asn Gly Gin Phe Trp Asp Val Lys Asp Ala He Lys Glu Met Gly Ser

290 295 300

He Gin Leu Gly He Glu He Ser Asp Ala Glu Ala Lys Lys He Glu 305 310 315 320

Thr Phe Phe Glu Ala Leu Lys Gly Lys Lys Pro Lys He He Tyr Pro

325 330 335

Glu Leu Pro Val Met Thr Asp Lys Thr Pro Lys Pro Ser Phe 340 345 350

(2) INFORMATION FOR SEQ ID NO: 864:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 73 ammo acids

(B) TYPE- ammo acid (D) TOPOLOGY, linear

(ii) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE.

(A) NAME/KEY: miscjeature

(B) LOCATION 1...73

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 864:

Met Met Asp Leu Glu Ser Leu Arg Gly Phe Ala Tyr Ala Phe Phe Thr

1 5 10 15

He Leu Phe Thr Leu Phe Leu Tyr Ala Tyr He Phe Ser Met Tyr Arg

20 25 30

Lys Gin Lys Lys Gly He Val Asp Tyr Glu Arg Tyr Gly Tyr Leu Ala

35 40 45

Leu Asn Asp Ala Leu Glu Asp Glu Leu He Glu Pro Arg His Lys Glu

50 55 60

Val His Asp Lys Gly He Lys Glu Ser 65 70

(2) INFORMATION FOR SEQ ID NO: 865:

(l) SEQUENCE CHARACTERISTICS: (A) LENGTH: 275 ammo acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(m) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A ) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 275

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 865:

Leu Leu Asp Val Lys Ala Asn Ser Pro Ala Tyr Gin Ala Val Leu Leu

1 5 10 15

Ala Leu Asn Ala Ala Val Gly Leu Trp Gin Val Thr Ser Tyr Ala Phe

20 25 30

Thr Ala Cys Gly Pro Gly Ser Asn Glu Asn Ala Asn Gly Gly He Gin

35 40 45

Thr Phe Asn Asn Val Pro Gly Gin Asn Thr Thr Thr He Thr Cys Asn

50 55 60

Ser Tyr Tyr Glu Pro Gly His Gly Gly Pro He Ser Thr Glu Asn Tyr 65 70 75 80

Ala He He Asn Lys Ala Tyr Gin He He Gin Lys Ala Leu Thr Ala

85 90 95

Asn Gly Glu Gly He Pro Val Leu Ser Asn Thr Thr Thr Lys Leu Asp

100 105 110

Phe Thr He Asn Gly Asp Lys Arg Thr Gly Gly Glu Pro Asn Lys Lys

115 120 125

Leu Val Tyr Pro Trp Ser His Gly Lys Pro He Ser Thr Ser Trp Asn

130 135 140

Ala Thr He Thr Val Pro Thr Thr Glu Asn He Asn Thr Thr Asn Ser 145 150 155 160

Ala Gin Glu Leu Leu Lys Gin Ala Ser He He He Thr Thr Leu Asn

165 170 175

Ser Ala Cys Pro Asn Phe Gin Asn Gly Gly Ser Gly Tyr Trp Ala Gly

180 185 190

He Ser Gly Asn Gly Thr Met Cys Gly Met Phe Lys Asn Glu He Ser

195 200 205

Ala He Gin Gly Met He Ala Asn Ala Gin Glu Ala Val Ala Gin Ala

210 215 220

Lys He Val Ser Glu Asn Thr Gin Asn Gin Asn Ser Leu Asp Ala Glu 225 230 235 240

Asn His Ser Thr Pro Thr Gin Thr Leu Val Leu Leu Lys Ala Cys Ser

245 250 255

Lys Thr Arg Ser Pro Ser Gly Asp Phe Lys Pro Ser Arg Thr Ser Gly

260 265 270

Glu Lys Leu 275

(2) INFORMATION FOR SEQ ID NO: 866:

(l) SEQUENCE CHARACTERISTICS: (A) LENGTH 90 ammo acids

(D) TOPOLOGY, linear

(n) MOLECULE TYPE: protein

(m) HYPOTHETICAL : YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...90

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 866:

Met Leu Thr He Glu Thr Ser Lys Lys Phe Asp Lys Asp Leu Lys He

1 5 10 15

Leu Val Lys Asn Gly Phe Asp Leu Lys Leu Leu Tyr Lys Val Val Gly

20 25 30

Asn Leu Ala Thr Glu Gin Pro Leu Glu Pro Lys Tyr Lys Asp His Pro

35 40 45

Leu Lys Gly Ala Leu Lys Asp Phe Arg Glu Cys His Leu Lys Pro Asp

50 55 60

Leu Leu Leu Val Tyr Gin He Lys Lys Gin Glu Asn Thr Leu Phe Leu 65 70 75 80

Val Arg Leu Gly Ser His Ser Glu Leu Phe

85 90

(2) INFORMATION FOR SEQ ID NO: 867:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 100 ammo acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...100

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 867:

Met Leu Glu He Glu Leu Lys Lys Lys Phe Thr Lys Asp Leu Lys Lys

1 5 10 15

His He Leu Asn Gin Lys He Glu Leu Glu Val Phe Asp Leu Val Val

20 25 30

Glu Asn Leu Arg Asn Gin He Pro Leu Asp Lys Arg Phe Lys Asp His

35 40 45

Ala Leu Ser Gly Thr Tyr Lys Gly Cys Arg Glu Arg His He Lys Pro 50 55 60

Asp Val Leu Leu Val Tyr Arg Val Lys Gly Asn Val Leu Thr Leu Val 65 70 75 80

Arg Leu Gly Ser His Ser Glu Leu Phe Cys Lys Pro Pro Thr Pro Leu

85 90 95

He Thr Leu Lys 100

(2) INFORMATION FOR SEQ ID NO: 868:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 89 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...89

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 868 :

Leu Val Val Ser Gly Ser Leu Gin Asn He Val Arg Ser Phe Leu Arg

1 5 10 15

Arg He Ser Val Phe Phe He He Asp Phe He Asn Phe He Phe Val

20 25 30

He Asp Gin He He His Phe Phe Gly Asp Phe Phe He Phe Phe Phe

35 40 45

Met Leu Asn Leu Phe Tyr He Leu He Arg Leu He Asp Leu He Val

50 55 60

Leu Ser Gly Phe Ser Val Val Leu Val Arg Leu Gly Arg Phe Phe Arg 65 70 75 80

Leu He Phe Ala Gly Ala Gin His Ala 85

(2) INFORMATION FOR SEQ ID NO: 869:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 479 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature (B) LOCATION 1...479

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 869:

Met Lys Lys Ser Leu Cys Leu Ser Phe Phe Leu Thr Phe Ser Asn Pro

1 5 10 15

Leu Gin Ala Leu Val He Glu Leu Leu Glu Glu He Lys Thr Ser Pro

20 25 30

His Lys Gly Thr Phe Lys Ala Lys Val Leu Asp Ser Lys Glu Pro Arg

35 40 45

Gin Val Leu Gly Val Tyr Asn He Ser Pro His Lys Lys Leu Thr Leu

50 55 60

Thr He Thr His He Ser Thr Ala He Val Tyr Gin Pro Leu Asp Glu 65 70 75 80

Lys Leu Ser Leu Glu Thr Thr Leu Ser Pro Asn Arg Pro Thr He Pro

85 90 95

Arg Asn Thr Gin He Val Pne Ser Ser Lys Glu Leu Lys Glu Pro His

100 105 110

Ser Asn Pro He Pro Ser Leu Asn Ala Pro Met Gin Lys Pro Gin Asn

115 120 125

Lys Pro Ser Ser Ser Gin Gin Ser Pro Gin Asn Phe Ser Tyr Pro Glu

130 135 140

Ser Lys Leu Gly Ser Lys Asn Ser Lys Asn Ser Leu Leu Gin Pro Leu 145 150 155 160

Val Thr Pro Ser Lys Val Ser Pro Thr Asn Glu Val Lys Thr Pro Thr

165 170 175

Asn Asp Ala Asn Pro Pro Leu Lys His Ser Ser Gin Asp Gin Glu Asn

180 185 190

Asn Leu Phe Val Ala Pro Pro Thr Glu Lys Thr Leu Pro Asn Asn Thr

195 200 205

Ser Ser Ala Asp Ala Ser Glu Asn Asn Glu Ser Asn Glu Asn Arg Asp

210 215 220

Asn Val Glu Lys Gin Ala He Arg Asp Pro Asn He Lys Glu Phe Ala 225 230 235 240

Cys Gly Lys Trp Val Tyr Asp Asp Glu Asn Leu Gin Ala Tyr Arg Pro

245 250 255

Ser He Leu Lys Arg Val Asp Lys Asp Lys Glu He Thr Thr Asp He

260 265 270

Thr Pro Cys Asp Tyr Ser Thr Ala Glu Asn Lys Ser Gly Lys He He

275 280 285

Thr Pro Tyr Thr Lys He Ser Val His Lys Thr Glu Pro Leu Glu Asp

290 295 300

Pro Gin Thr Phe Glu Ala Lys Asn Asn Phe Ala He Leu Gin Ala Arg 305 310 315 320

Ser Ser Thr Glu Lys Cys Lys Arg Ala Arg Ala Arg Lys Asp Gly Thr

325 330 335

Thr Arg Gin Cys Tyr Leu He Glu Glu Pro Leu Lys Gin Ala Trp Glu

340 345 350

Ser Glu Tyr Glu He Thr Thr Gin Leu Val Lys Ala He Tyr Glu Arg

355 360 365

Pro Lys Gin Asp Asp Gin Val Glu Pro Thr Phe Tyr Glu Thr Ser Glu

370 375 380

Leu Ala Tyr Ser Ser Thr Arg Lys Ser Glu He Thr Arg Asn Glu Leu 385 390 395 400

Asn Leu Asn Glu Lys Phe Met Glu Phe Val Glu Val Tyr Glu Gly His

405 410 415

Tyr Leu Asn Asp He He Lys Glu Ser Ser Glu Tyr Lys Glu Trp Val 420 425 430

Lys Asn His Val Arg Phe Lys Glu Gly Val Cys Met Ala Leu Glu He

435 440 445

Glu Glu Gin Pro Arg Ala Lys Ser Thr Pro Leu Ser He Glu Asn Ser

450 455 460

Arg Val Val Cys Val Lys Lys Gly Asn Tyr Leu Phe Asn Glu Val 465 470 475

(2) INFORMATION FOR SEQ ID NO.870.

(l) SEQUENCE CHARACTERISTICS.

(A) LENGTH: 479 ammo acids

(D) TOPOLOGY: linear

(n) MOLECULE TYPE, protein

(m) HYPOTHETICAL- YES

(vi) ORIGINAL SOURCE.

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...479

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 870:

Met Lys Lys Ser Leu Cys Leu Ser Phe Phe Leu Thr Phe Ser Asn Pro

1 5 10 15

Leu Gin Ala Leu Val He Glu Leu Leu Glu Glu He Lys Thr Ser Pro

20 25 30

His Lys Gly Thr Phe Lys Ala Lys Val Leu Asp Ser Lys Glu Pro Arg

35 40 45

Gin Val Leu Gly Val Tyr Asn He Ser Pro His Lys Lys Leu Thr Leu

50 55 60

Thr He Thr His He Ser Thr Ala He Val Tyr Gin Pro Leu Asp Glu 65 70 75 80

Lys Leu Ser Leu Glu Thr Thr Leu Ser Pro Asn Arg Pro Thr He Pro

85 90 95

Arg Asn Thr Gin He Val Phe Ser Ser Lys Glu Leu Lys Glu Pro His

100 105 110

Ser Asn Pro He Pro Ser Leu Asn Ala Pro Met Gin Lys Pro Gin Asn

115 120 125

Lys Pro Ser Ser Ser Gin Gin Ser Pro Gin Asn Phe Ser Tyr Pro Glu

130 135 140

Ser Lys Leu Gly Ser Lys Asn Ser Lys Asn Ser Leu Leu Gin Pro Leu 145 150 155 160

Val Thr Pro Ser Lys Val Ser Pro Thr Asn Glu Val Lys Thr Pro Thr

165 170 175

Asn Asp Ala Asn Pro Pro Leu Lys His Ser Ser Gin Asp Gin Glu Asn

180 185 190

Asn Leu Phe Val Ala Pro Pro Thr Glu Lys Thr Leu Pro Asn Asn Thr

195 200 205

Ser Ser Ala Asp Ala Ser Glu Asn Asn Glu Ser Asn Glu Asn Arg Asp

210 215 220

Asn Val Glu Lys Gin Ala He Arg Asp Pro Asn He Lys Glu Phe Ala 225 230 235 240

Cys Gly Lys Trp Val Tyr Asp Asp Glu Asn Leu Gin Ala Tyr Arg Pro

245 250 255

Ser He Leu Lys Arg Val Asp Lys Asp Lys Glu He Thr Thr Asp He

260 265 270

Thr Pro Cys Asp Tyr Ser Thr Ala Glu Asn Lys Ser Gly Lys He He

275 280 285

Thr Pro Tyr Thr Lys He Ser Val His Lys Thr Glu Pro Leu Glu Asp

290 295 300

Pro Gin Thr Phe Glu Ala Lys Asn Asn Phe Ala He Leu Gin Ala Arg 305 310 315 320

Ser Ser Thr Glu Lys Cys Lys Arg Ala Arg Ala Arg Lys Asp Gly Thr

325 330 335

Thr Arg Gin Cys Tyr Leu He Glu Glu Pro Leu Lys Gin Ala Trp Glu

340 345 350

Ser Glu Tyr Glu He Thr Thr Gin Leu Val Lys Ala He Tyr Glu Arg

355 360 365

Pro Lys Gin Asp Asp Gin Val Glu Pro Thr Phe Tyr Glu Thr Ser Glu

370 375 380

Leu Ala Tyr Ser Ser Thr Arg Lys Ser Glu He Thr Arg Asn Glu Leu 385 390 395 400

Asn Leu Asn Glu Lys Phe Met Glu Phe Val Glu Val Tyr Glu Gly His

405 410 415

Tyr Leu Asn Asp He He Lys Glu Ser Ser Glu Tyr Lys Glu Trp Val

420 425 430

Lys Asn His Val Arg Phe Lys Glu Gly Val Cys Met Ala Leu Glu He

435 440 445

Glu Glu Gin Pro Arg Ala Lys Ser Thr Pro Leu Ser He Glu Asn Ser

450 455 460

Arg Val Val Cys Val Lys Lys Gly Asn Tyr Leu Phe Asn Glu Val 465 470 475

(2) INFORMATION FOR SEQ ID NO: 871:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 300 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME / KEY : miscjeature

( B ) LOCATION 1 . . . 300

( xi ) SEQUENCE DESCRIPTION : SEQ ID N0 . 871 :

Met Arg Lys Thr He Ser Ala Leu Phe Leu Ser Ala Cys He Gly Leu

1 5 10 15

Ser Ser Val His Ala Ser Asn Ala Leu He Leu Gin Thr Asp Phe Ser

20 25 30

Leu Lys Asp Gly Ala Val Ser Ala Met Lys Gly Val Ala Phe Ser Val 35 40 45

Asp Ser Asn Leu Lys He Phe Asp Leu Thr His Glu He Pro Pro Tyr

50 55 60

Asn He Trp Glu Gly Ala Tyr Arg Leu Tyr Gin Thr Ala Ser Tyr Trp 65 70 75 80

Pro Lys Gly Ser Val Phe Val Ser Val Val Asp Pro Gly Val Gly Thr

85 90 95

Asn Arg Lys Ser Val Val Leu Lys Thr Lys Asn Gly Gin Tyr Phe Val

100 105 110

Ser Pro Asp Asn Gly Thr Leu Thr Leu Val Ala Gin Thr Leu Gly He

115 120 125

Asp Ser Val Arg Glu He Asp Glu Lys Ala Asn Arg Leu Lys Gly Ser

130 135 140

Glu Lys Ser Tyr Thr Phe His Gly Arg Asp Val Tyr Ala Tyr Thr Gly 145 150 155 160

Ala Arg Leu Ala Ser Gly Ala He Thr Phe Glu Gin Val Gly Pro Glu

165 170 175

Leu Pro He Lys Val Val Glu He Pro Tyr Gin Lys Ala Lys Ala Thr

180 185 190

Lys Gly Gly Val Lys Gly Asn He Pro He Leu Asp He Gin Tyr Gly

195 200 205

Asn Val Trp Ser Asn He Ser Asp Lys Leu Leu Asn Gin Ala Gly He

210 215 220

Lys Arg Asn Asp Thr Val Cys Val Thr He Phe Lys Asn Ser Lys Lys 225 230 235 240

Gin Tyr Glu Gly Lys Met Pro Tyr Val Ala Ser Phe Gly Asp Val Pro

245 250 255

Glu Gly Gin Pro Leu Val Tyr Leu Asn Ser Leu Leu Asn Val Ser Val

260 265 270

Ala Leu Asn Met Asp Asn Phe Ala Gin Lys His Gin He Lys Ser Gly

275 280 285

Ala Asp Trp Asn He Asp He Lys Lys Cys Ala Lys 290 295 300

(2) INFORMATION FOR SEQ ID NO: 872:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 156 ammo acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...156

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 872 :

Leu Thr Lys Lys Phe Met Ser Trp Met Val Val He Gly Ala Leu He

1 5 10 15

Cys Val Leu Leu Gly Val Phe He Phe Phe Thr Ser Met Ser Val Lys 20 25 30

Lys Ser Leu Thr Ala Tyr Leu Asn Ala Tyr Leu Glu Gin Arg Pro Asn

35 40 45

He Glu Gly Met Gly He He Gly Val Pro Phe Lys Cys Glu Arg Phe

50 55 60

Phe Lys He Ala Cys Val Ser Lys Glu Leu Arg Phe Leu Asp Pro Gin 65 70 75 80

Asn Ser Pro He Met Asp Phe Lys Asn Leu Lys He Lys Leu His Ser

85 90 95

Leu Asp Lys Ser Ser Leu Thr Leu Ser He His Ser Gin He Gin Ser

100 105 110

Pro He Leu Glu Gin Ser He Gin Gin Lys He Ser Gin He Pro Leu

115 120 125

Lys Asn Leu Asn Ala Leu Leu Glu Lys Phe Lys Pro Thr Arg Leu Asn

130 135 140

Cys Ser Leu Thr Phe Asn Ala Leu Asp Glu Lys Thr 145 150 155

(2) INFORMATION FOR SEQ ID NO: 873:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 285 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...285

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 873 :

Met Gin Asp Phe He Lys He Phe He Gin Glu Val Val Ser Thr Leu

1 5 10 15

Glu Gly Leu Val Gly Lys Ala Pro Ser Val Gly Leu Glu Lys Glu Val

20 25 30

Ser Asn Asn Glu Glu Ala Ser Leu He Ser Thr Pro Tyr Ala Arg Val

35 40 45

Lys He Ser Ala He Glu Lys Asn Glu Ser Pro He Glu Leu Leu Ala

50 55 60

Pro Val Asp Leu Val Thr Ala Leu Ser Asp Leu Met Leu Gly Gly Glu 65 70 75 80

Gly Ala Ser Lys Glu Glu Met Asp Asn Asp Asp Leu Asp Ala Phe Lys

85 90 95

Glu Met Ala Ser Asn He Phe Gly Ala He Ala Thr Ser Leu Lys Ser

100 105 110

Gin Glu Leu Leu Pro Lys Leu Asn Phe Thr Thr Thr Asn Ala Glu He

115 120 125

Ala Lys Glu Leu Pro Lys Lys Glu Asp Tyr Ala Lys Ala Met Val Phe

130 135 140

Ser Phe Lys Met Glu Ala He Lys Glu Ser Gin He Val Leu Leu He 145 150 155 160

Thr Ser Ala Phe Glu Gly Gin Phe Glu Lys Thr His Lys Glu Glu Lys

165 170 175

Glu Glu Thr Thr Lys Ser Ala Thr Glu Glu Thr Lys Thr His Asp Ala

180 185 190

Ser Leu Glu Asn He Glu He Arg Asn He Ser Met Leu Leu Asp Val

195 200 205

Lys Leu Asn Val Lys Val Arg He Gly Gin Lys Lys Met He Leu Lys

210 215 220

Asp Val Val Ser Met Asp He Gly Ser Val Val Glu Leu Asp Gin Leu 225 230 235 240

Val Asn Asp Pro Leu Glu He Leu Val Asp Asp Lys Val He Ala Lys

245 250 255

Gly Glu Val Val He Val Asp Gly Asn Phe Gly He Gin He Thr Asp

260 265 270

He Gly Thr Lys Lys Glu Arg Leu Glu Gin Leu Lys Asn 275 280 285

(2) INFORMATION FOR SEQ ID NO: 874:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 329 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...329

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 874 :

Met Thr Thr Lys Arg Val Asn Thr Ala Thr Asn Lys He Met Thr Leu

1 5 10 15

Asn Thr Phe Leu Asp Thr Cys Phe Leu Phe Phe He Ser He Leu Phe

20 25 30

Tyr Leu Ser He Pro He Tyr Pro Asn Lys Val Val Val Val Pro Gin

35 40 45

Gly Ser Leu Lys Lys Val Phe Phe Ser Leu Lys Glu Gin Gly Val Asp

50 55 60

He Asn Ala Leu Asp Leu Leu Leu Leu Arg Leu Met Gly Met Pro Lys 65 70 75 80

Lys Gly Tyr He Asp Met Gly Asp Gly Ala Leu Arg Lys Gly Asp Phe

85 90 95

Leu Val Arg Leu He Lys Ala Lys Thr Ala Gin Lys Ser Val Thr Leu

100 105 110

He Pro Gly Glu Thr Arg Tyr Phe Phe Thr Gin He Leu Ser Glu Thr

115 120 125

Tyr Gin Leu Glu Thr Ser Asp Leu Asn Glu Ala Tyr Glu Ser He Ala

130 135 140

Pro Arg Leu Asn Gly Ala Val He Glu Asp Gly Val He Trp Pro Asp 145 150 155 160

Thr Tyr His Leu Pro Leu Gly Glu Asp Ala Phe Lys He Met Gin Thr

165 170 175

Leu He Gly Gin Ser Met Lys Lys His Glu Ala Leu Ser Lys Gin Trp

180 185 190

Leu Gly Tyr Tyr His Lys Glu Glu Trp Phe Glu Lys He He Leu Ala

195 200 205

Ser He Val Gin Lys Glu Ala Ala Asn Val Glu Glu Met Pro Leu He

210 215 220

Ala Ser Val He Phe Asn Arg Leu Lys Lys Gly Met Pro Leu Gin Met 225 230 235 240

Asp Gly Ala Leu Asn Tyr Gin Glu Phe Ser His Ala Lys Val Thr Lys

245 250 255

Glu Arg He Lys Thr Asp Asn Thr Pro Tyr Asn Thr Tyr Lys Phe Lys

260 265 270

Gly Leu Pro Lys Asn Pro Val Gly Ser Val Ser Leu Glu Ala Val Arg

275 280 285

Ala Val Val Phe Pro Lys Lys Thr Asp Phe Leu Tyr Phe Val Lys Met

290 295 300

Pro Asp Lys Lys His Ala Phe Ser Ala Thr Tyr Lys Glu His Leu Lys 305 310 315 320

Asn He Asn He Ser Asn Asn His Phe 325

(2) INFORMATION FOR SEQ ID NO: 875:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 146 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...146

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 875:

Met Arg Leu Leu Phe Leu Leu Leu Ser Ala Thr Leu Met Leu Leu Ala

1 5 10 15

Glu Glu Lys He Pro Leu Ser Asp Asp Ala Pro He Lys Leu Val His

20 25 30

Trp Gin Asn Ala Leu Lys Glu Val Gin Pro Asp Ser Asn Ala Pro Ala

35 40 45

Thr Pro Pro He Lys Ala Val Gin Thr Thr Leu Thr Phe Glu Thr Pro

50 55 60

Phe Asn Lys Thr Pro Lys He Met Glu Val Glu Gly Gin Lys Val He

65 70 75 80

Val Leu Lys Asn Ala Gin Leu Asp Ser Lys Lys Thr Met Asp Phe Lys

85 90 95

Glu Ala Ser Leu Asn Ala Leu Glu Met Phe Ser Tyr Gin Asn Asp He 100 105 110

Tyr Leu Leu Ser Lys Lys Ala Lys Ala Gly Leu Glu He Gin Ala Ser

115 120 125

Ser Ser Lys Asp Lys Lys Gin Leu Ala Phe Phe Phe Tyr Pro Lys Val

130 135 140

Phe He 145

(2) INFORMATION FOR SEQ ID NO: 876:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 660 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL : YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 660

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 876 :

Met Leu Lys Lys He Phe Tyr Gly Phe He Val Leu Phe Leu He He

1 5 10 15

Val Gly Leu Leu Ala Val Leu Val Ala Gin Val Trp Val Thr Thr Asp

20 25 30

Lys Asp He Ala Lys He Lys Asp Tyr Arg Pro Ser Val Ala Ser Gin

35 40 45

He Leu Asp Arg Lys Gly Arg Leu He Ala Asn He Tyr Asp Lys Glu

50 55 60

Phe Arg Phe Tyr Ala Arg Phe Glu Glu He Pro Pro Arg Phe Val Glu 65 70 75 80

Ser Leu Leu Ala Val Glu Asp Thr Leu Phe Phe Glu His Gly Gly He

85 90 95

Asn Leu Asp Ala Val Met Arg Ala Met He Lys Asn Ala Lys Ser Gly

100 105 110

Arg Tyr Thr Glu Gly Gly Ser Thr Leu Thr Gin Gin Leu Val Lys Asn

115 120 125

Met Val Leu Thr Arg Glu Lys Thr Leu Thr Arg Lys Leu Lys Glu Ala

130 135 140

He He Ser He Arg He Glu Lys Val Leu Ser Lys Glu Glu He Leu 145 150 155 160

Glu Arg Tyr Leu Asn Gin Thr Phe Phe Gly His Gly Tyr Tyr Gly Val

165 170 175

Lys Thr Ala Ser Leu Gly Tyr Phe Lys Lys Pro Leu Asp Lys Leu Thr

180 185 190

Leu Lys Glu He Thr Met Leu Val Ala Leu Pro Arg Ala Pro Ser Phe

195 200 205

Tyr Asp Pro Thr Lys Asn Leu Glu Phe Ser Leu Ser Arg Ala Asn Asp

210 215 220

He Leu Arg Arg Leu Tyr Ser Leu Gly Trp He Ser Ser Asn Glu Leu 225 230 235 240

Lys Ser Ala Leu Asn Glu Val Pro He Val Tyr Asn Gin Thr Ser Thr

245 250 255

Gin Asn He Ala Pro Tyr Val Val Asp Glu Val Leu Lys Gin Leu Asp

260 265 270

Gin Leu Asp Gly Leu Lys Thr Gin Gly Tyr Thr He Lys Leu Thr He

275 280 285

Asp Leu Asp Tyr Gin Arg Leu Ala Leu Glu Ser Leu Arg Phe Gly His

290 295 300

Gin Lys He Leu Glu Lys He Ala Lys Glu Lys Pro Lys Thr Asn Ala 305 310 315 320

Ser Asn Asp Lys Asp Glu Asp Asn Leu Asn Ala Ser Met He Val Thr

325 330 335

Glu Thr Ser Thr Gly Lys He Leu Ala Leu Val Gly Gly He Asp Tyr

340 345 350

Lys Lys Ser Ala Phe Asn Arg Ala Thr Gin Ala Lys Arg Gin Phe Gly

355 360 365

Ser Ala He Lys Pro Phe Val Tyr Gin He Ala Phe Asp Asn Gly Tyr

370 375 380

Ser Thr Thr Ser Lys He Pro Asp Thr Ala Arg Asn Phe Glu Asn Gly 385 390 395 400

Asn Tyr Ser Lys Asn Ser Val Gin Asn His Ala Trp His Pro Ser Asn

405 410 415

Tyr Thr Arg Lys Phe Leu Gly Leu Val Thr Leu Gin Glu Ala Leu Ser

420 425 430

His Ser Leu Asn Leu Ala Thr He Asn Leu Ser Asp Gin Leu Gly Phe

435 440 445

Glu Lys He Tyr Gin Ser Leu Ser Asp Met Gly Phe Lys Asn Leu Pro

450 455 460

Lys Asp Leu Ser He Val Leu Gly Ser Phe Ala He Ser Pro He Asp 465 470 475 480

Ala Ala Glu Lys Tyr Ser Leu Phe Ser Asn Tyr Gly Thr Met Leu Lys

485 490 495

Pro Met Leu He Glu Ser He Thr Asn Gin Gin Asn Glu Val Lys Thr

500 505 510

Phe Thr Pro He Glu Thr Lys Lys He Thr Ser Lys Glu Gin Ala Phe

515 520 525

Leu Thr Leu Ser Ala Leu Met Asp Ala Val Glu Asn Gly Thr Gly Ser

530 535 540

Leu Ala Arg He Lys Gly Leu Glu He Ala Gly Lys Thr Gly Thr Ser 545 550 555 560

Asn Asn Asn He Asp Ala Trp Phe He Gly Phe Thr Pro Thr Leu Gin

565 570 575

Ser Val He Trp Phe Gly Arg Asp Asp Asn Thr Pro He Gly Lys Gly

580 585 590

Ala Thr Gly Gly Val Val Ser Ala Pro Val Tyr Ser Tyr Phe Met Arg

595 600 605

Asn He Leu Ala He Glu Pro Ser Leu Lys Arg Lys Phe Asp Val Pro

610 615 620

Lys Gly Leu Arg Lys Glu He Val Asp Lys He Pro Tyr Tyr Ser Ser 625 630 635 640

Pro Asn Ser He Thr Pro Thr Pro Lys Lys Thr Asp Asp Ser Glu Glu

645 650 655

Arg Leu Leu Phe 660

(2) INFORMATION FOR SEQ ID NO: 877: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 113 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...113

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 877:

Met Ala Lys Met Asn Ala Pro Asp Gly Val Ala Val Trp Val Asn Glu

1 5 10 15

Asp Arg Cys Lys Gly Cys Asp He Cys Val Ser Val Cys Pro Ala Gly

20 25 30

Val Leu Gly Met Gly He Glu Lys Glu Arg Val Leu Gly Lys Val Ala

35 40 45

Lys Val Ala Tyr Pro Glu Ser Cys He Gly Cys Val Gin Cys Glu Leu

50 55 60

His Cys Pro Asp Phe Ala He Tyr Val Ala Asp Arg Lys Asp Phe Lys 65 70 75 80

Phe Ala Lys Val Ser Lys Glu Ala Gin Glu Arg Ser Glu Lys Val Lys

85 90 95

Ala Asn Lys Tyr Met Leu Leu Glu Glu Thr He Leu Glu Gly Arg Gly

100 105 110

Lys

(2) INFORMATION FOR SEQ ID NO: 878:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 339 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...339

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 878: Met He Phe He Asp Ala Cys Phe Arg Lys Glu Thr Pro Tyr Thr Pro 1 5 10 15

He Trp Met Met Arg Gin Ala Gly Arg Tyr Leu Ser Glu Tyr Gin Glu

20 25 30

Ser Arg Lys Lys Ala Gly Ser Phe Leu Glu Leu Cys Lys Asn Ser Asp

35 40 45

Leu Ala Thr Glu Val Thr Leu Gin Pro Val Glu He Leu Gly Val Asp

50 55 60

Ala Ala He Leu Phe Ser Asp He Leu Val Val Pro Leu Glu Met Gly 65 70 75 80

Leu Asn Leu Glu Phe He Pro Lys Lys Gly Pro His Phe Leu Glu Thr

85 90 95

He Thr Asp Leu Lys Ser Val Glu Ser Leu Lys Val Gly Val Tyr Lys

100 105 110

Gin Leu Asn Tyr Val Tyr Asp Thr He Ser Gin Thr Arg Gin Lys Leu

115 120 125

Ser Lys Glu Lys Ala Leu He Gly Phe Cys Gly Ser Pro Trp Thr Leu

130 135 140

Ala Thr Tyr Met He Glu Gly Glu Gly Ser Lys Ser Tyr Ala Lys Ser 145 150 155 160

Lys Lys Met Leu Tyr Ser Glu Pro Glu Val Leu Lys Ala Leu Leu Glu

165 170 175

Lys Leu Ser Leu Glu Leu He Glu Tyr Leu Ser Leu Gin He Gin Ala

180 185 190

Gly Val Asn Ala Val Met He Phe Asp Ser Trp Ala Ser Ala Leu Glu

195 200 205

Lys Glu Ala Tyr Leu Glu Phe Ser Trp Asp Tyr Leu Lys Lys He Ser

210 215 220

Lys Glu Leu Lys Lys Arg Tyr Ala His He Pro Val He Leu Phe Pro 225 230 235 240

Lys Gly He Gly Ala Tyr Leu Asp Ser He Asp Gly Glu Phe Asp Val

245 250 255

Phe Gly Val Asp Trp Gly Thr Pro Leu Thr Ala Ala Lys Lys He Leu

260 265 270

Gly Gly Lys Tyr Val Leu Gin Gly Asn Leu Glu Pro Thr Arg Leu Tyr

275 280 285

Asp Lys Asn Ala Leu Glu Glu Gly Val Glu Lys He Leu Lys Val Met

290 295 300

Gly Asn Gin Gly His He Phe Asn Leu Gly His Gly Met Leu Pro Asp 305 310 315 320

Leu Pro Arg Glu Asn Ala Lys Tyr Leu Val Gin Leu Val His Ala Lys

325 330 335

Thr Arg Arg

(2) INFORMATION FOR SEQ ID NO: 879:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 192 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori ( ix ) FEATURE :

( A ) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 192

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 879:

Val Leu Glu Lys Ser Phe Leu Lys Ser Lys Gin Leu Val Leu Cys Gly

1 5 10 15

Leu Gly Val Leu Met Leu Gin Ala Cys Thr Cys Pro Asn Thr Ser Gin

20 25 30

Arg Asn Ser Phe Leu Gin Asp Val Pro Tyr Trp Met Leu Gin Asn Arg

35 40 45

Ser Gin Tyr Leu Thr Gin Gly Val Asp Ser Ser His He Val Asp Gly

50 55 60

Lys Ala Thr Glu Glu He Glu Lys He Ala Thr Lys Arg Ala Thr He 65 70 75 80

Arg Val Ala Gin Asn He Val His Lys Leu Lys Glu Ala Tyr Leu Ser

85 90 95

Lys Ser Asn Arg He Lys Gin Lys He Thr Asn Glu Met Phe He Gin

100 105 110

Met Thr Lys Pro He Phe Asp Ser Leu Met Asn Val Asp Arg Leu Gly

115 120 125

He Tyr He Asn Pro Asn Asn Glu Glu Val Phe Ala Leu Val Arg Ala

130 135 140

Arg Ser Phe Asp Lys Asp Ala Leu Ser Glu Gly Leu His Lys Met Ser 145 150 155 160

Leu Asp Asp Gin Ala Val Ser He Leu Val Ser Lys Val Glu Glu He

165 170 175

Phe Lys Asp Ser He Asn Tyr Gly Asp Val Lys Val Pro He Ala Met 180 185 190

(2) INFORMATION FOR SEQ ID NO: 880:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 110 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME/ KEY : mi scjeature

( B ) LOCATION 1 . . . 110

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 880 :

Met Leu Arg Asn Gin Phe Arg He Val Phe Val Ser Cys He Val Ala

1 5 10 15

Ser Ser Leu Gin Ala Gin Glu Asn Thr His Thr Leu Gly Lys Val Thr

20 25 30

Thr Lys Gly Glu Arg Thr Phe Glu Tyr Asn Asn Lys Met Tyr He Asp 35 40 45

Arg Lys Glu Leu Gin Gin Arg Gin Ser Asn Gin He Arg Asp He Phe

50 55 60

Arg Thr Arg Ala Asp Val Asn Val Ala Ser Gly Gly Leu Met Ala Gin 65 70 75 80

Lys He Tyr Val Arg Gly He Glu Ser Arg Leu Leu Arg Val Thr He

85 90 95

Asp Gly Val Ala Gin Asn Gly Asn He Phe His His Asp Ala 100 105 110

(2) INFORMATION FOR SEQ ID NO: 881:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 89 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...89

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 881 :

Val Met Lys Lys He Val Val Ser Leu Cys Val Ala Leu Gly Phe Leu

1 5 10 15

Ser Ala Asp Pro Ala Gin Ala Asn Lys Ala He Ser Asp Ala Asp Leu

20 25 30

He Glu Glu He Arg Asp Leu Lys Lys He He Ser Ala Gin Asn Thr

35 40 45

Glu He Asn Gin Leu Arg Lys Val Gin Glu Val Leu Ser Gly Gin Leu

50 55 60

Gly Asp Met Arg Lys Asp He Leu Ser Thr Arg Asp Tyr Cys He Ser 65 70 75 80

Leu Arg Pro Tyr He Tyr Asn Trp Arg 85

(2) INFORMATION FOR SEQ ID NO: 882:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 158 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori ( ix ) FEATURE :

(A) NAME/KEY: miscjeature

(B) LOCATION 1...158

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 882:

Leu Asn Lys Phe Gly Trp Arg Ala Cys Phe Leu Thr Leu Phe Phe Ser

1 5 10 15

Gly Tyr Ser Lys Lys Ala Pro Gly Thr He Gly Ser Leu Val Ala Leu

20 25 30

Leu Leu Gly Leu Pro He Leu He Phe Ser Ala Asn Thr Leu Phe Leu

35 40 45

Gly Ala He Phe Val Gly Leu He Ala He Thr Gin He Asp Lys Glu

50 55 60

Glu Glu Glu Thr Lys Arg His Asp Ser Ser Tyr He Val He Asp Glu 65 70 75 80

Leu Val Gly Met Trp Leu Ala Met Ala He Ser Gly Leu Ser Leu Val

85 90 95

Gly Val He Leu Ser Phe He Phe Phe Arg He Tyr Asp He Thr Lys

100 105 110

Pro Ser Leu He Gly Lys He Asp Lys Glu Val Lys Gly Gly Leu Gly

115 120 125

Val Val Ala Asp Asp Ala Leu Ala Gly Val Leu Ala Gly Leu Ser Thr

130 135 140

Leu Leu Ala He Asn He Leu Gly Phe Phe Asn He Lys Phe 145 150 155

(2) INFORMATION FOR SEQ ID NO: 883:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 133 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...133

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 883 :

Met Glu Leu He Lys Lys Leu Glu Lys Glu Ser Glu Val Leu Lys Lys

1 5 10 15

Asp Leu Gin Gin His Ser Asn Glu Leu Phe Lys Met Leu He He Asp

20 25 30

Asn Glu Asp Leu Phe Lys Glu Gin Phe Glu He Met Phe Lys Ala Trp

35 40 45

Val Glu He Val Lys Met Met Phe Glu Leu Thr Lys Lys Thr Lys Phe

50 55 60

Asp Gly Glu Met He Gly Tyr Thr Glu Glu Leu Leu Thr Phe Leu Val 65 70 75 80 Arg Asp Phe Phe Asn Gly He Phe Lys Ser Lys Val He Pro Lys Met

85 90 95

Pro He Phe Cys Gly Asp Val Lys Cys Glu Asp Phe Asn Ala Leu Arg

100 105 110

Ser Leu Val Tyr Leu Ser Val Leu Glu Leu Glu Glu Thr He Asn Pro

115 120 125

Asn Lys He Pro Phe 130

(2) INFORMATION FOR SEQ ID NO: 884:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 133 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...133

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 884 :

Met Glu Leu He Lys Lys Leu Glu Lys Glu Ser Glu Val Leu Lys Lys

1 5 10 15

Asp Leu Gin Gin His Ser Asn Glu Leu Phe Lys Met Leu He He Asp

20 25 30

Asn Glu Asp Leu Phe Lys Glu Gin Phe Glu He Met Phe Lys Ala Trp

35 40 45

Val Glu He Val Lys Met Met Phe Glu Leu Thr Lys Lys Thr Lys Phe

50 55 60

Asp Gly Glu Met He Gly Tyr Thr Glu Glu Leu Leu Thr Phe Leu Val 65 70 75 80

Arg Asp Phe Phe Asn Gly He Phe Lys Ser Lys Val He Pro Lys Met

85 90 95

Pro He Phe Cys Gly Asp Val Lys Cys Glu Asp Phe Asn Ala Leu Arg

100 105 110

Ser Leu Val Tyr Leu Ser Val Leu Glu Leu Glu Glu Thr He Asn Pro

115 120 125

Asn Lys He Pro Phe 130

(2) INFORMATION FOR SEQ ID NO: 885:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 125 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein (m) HYPOTHETICAL. YES

(vi) ORIGINAL SOURCE-

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...125

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 885:

Met Lys Lys Leu Ala Ala Leu Phe Leu Val Ser Ala Leu Gly Val Met

1 5 10 15

Ser Leu Asn Ala Trp Glu Gin Thr Leu Lys Ala Asn Asp Leu Glu Val

20 25 30

Lys He Lys Ser Val Gly Asn Pro He Lys Gly Asp Asn Thr Phe Val

35 40 45

Leu Ser Pro Thr Leu Lys Gly Lys Ala Leu Glu Lys Ala He Val Arg

50 55 60

Val Gin Phe Met Met Pro Glu Met Pro Gly Met Pro Ala Met Lys Glu 65 70 75 80

Met Ala Gin Val Ser Glu Lys Asn Gly Leu Tyr Glu Ala Lys Thr Asn

85 90 95

Leu Ser Met Asn Gly Thr Trp Gin Val Arg Val Asp He Lys Ser Lys

100 105 110

Glu Gly Gin Val Tyr Arg Thr Lys Thr Ser Leu Asp Leu 115 120 125

(2) INFORMATION FOR SEQ ID NO: 886:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 341 ammo acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...341

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 886:

Met Lys Arg Leu Leu Leu Leu Ala Leu Ala Leu Phe Phe Ser Leu Ser

1 5 10 15

Cys Thr Asn Ala Gin Glu He Lys Glu Thr Gin Glu Thr Lys Lys Thr

20 25 30

Lys Glu Thr Lys Ser Gin Thr Arg Phe Asn He Ser Thr Thr Lys Val

35 40 45

He Glu Lys Glu Phe Ser Gin Ser Arg Arg Tyr Tyr Ala Leu Leu Glu

50 55 60

Pro Asn Glu Ala Leu He Phe Ser Gin Thr Leu Arg Phe Asp Gly Tyr 65 70 75 80

Val Glu Lys Leu Tyr Ala Asn Lys Thr Tyr Thr Pro He Lys Lys Gly

85 90 95

Asp Arg Leu Leu Ser Val Tyr Ser Pro Glu Leu Ala Gly Val Gin Ser

100 105 110

Glu Leu Leu Ser Ser Leu Lys Phe Asn Gin Gin Val Gly Ala He Lys

115 120 125

Glu Lys Leu Lys Leu Leu Gly Leu Glu Asn Phe Ser He Glu Lys He

130 135 140

He Ser Ser His Lys Val Gin Asn Glu He Thr He Tyr Ser Arg Phe 145 150 155 160

Asn Gly Val He Phe Lys Lys Ser Pro Asp Leu Asn Glu Gly Ser Phe

165 170 175

He Lys Lys Gly Gin Glu Leu Phe Lys He He Asp Leu Ser Arg Leu

180 185 190

Trp Ala Leu Val Lys Val Asn Gin Glu Asp Leu Glu Phe Leu Lys Asn

195 200 205

Thr His Gin Ala He Leu Phe Val Glu Gly Val Lys Gly Lys Gin Ala

210 215 220

He Thr Leu Glu Asn He Asn Pro He He Asn Ala Gin Asp Lys Met 225 230 235 240

Leu Glu Ala Arg Phe Asn Val Pro Asn Leu Lys Leu Leu Tyr Tyr Pro

245 250 255

Asn Met Phe Ala Gin Val Glu He Phe His Lys Pro Gin Lys Met Lys

260 265 270

He Leu Pro Lys Glu Ala Val Leu He Lys Gly Gly Lys Ala He Val

275 280 285

Phe Lys Lys Asp Asp Phe Gly Leu Ser Pro Leu Glu He Lys Ala Val

290 295 300

Arg Leu Ser Asp Gly Ser Tyr Glu He Leu Glu Gly Leu Lys Ala Gly 305 310 315 320

Glu Glu Val Ala Asn Asn Ala Leu Phe Val Leu Asp Ala Asp Ala Gin

325 330 335

Asn Asn Gly Asp Tyr 340

(2) INFORMATION FOR SEQ ID NO: 887:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 120 ammo acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(m) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 120

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 887: Met Gly Val Ala Val Val Leu Phe Leu Thr Leu He Leu Leu Phe Leu 1 5 10 15

Val Leu Arg Asp Phe Gly Leu Ala Ser Pro Lys Gin Lys He Leu Ala

20 25 30

Phe Leu He Val Gly He He Gly Ala Ser He Ser Val Tyr Thr Tyr

35 40 45

Lys Gin Asn Gin Gin Asn Gin Gin Glu He Ala Leu Gin Arg Ala Phe

50 55 60

Leu Arg Gly Glu Thr Leu Leu Cys Lys Gly He Lys Val Asn Asn Gin 65 70 75 80

Thr Phe Asn Leu Val Ser Gly Thr Leu Ser Phe Leu Gly Lys Lys Gin

85 90 95

Thr Pro Met Lys Asp Val Leu Val Asp Leu Asp Ser Cys Gin Thr Leu

100 105 110

Gin Lys Asp Pro Leu He Gin Pro 115 120

(2) INFORMATION FOR SEQ ID NO: 888:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 332 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 332

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 888 :

Met Arg Phe Phe He Leu Phe Phe Met Gly Met Leu Gly Val Gly Phe

1 5 10 15

Ser Gin Thr Glu Leu Asp Leu Lys Asp Leu Glu Lys Lys Pro Ala Gly

20 25 30

He Val Arg Asp Tyr Tyr Leu Trp Arg Tyr He Ser Asp Lys Lys Thr

35 40 45

Ser Leu Glu Asn Ala Lys Lys Ala Tyr Glu Leu Thr Gin Asn Lys Asn

50 55 60

Ser Ala Leu Gin Lys Ala Met Gin Glu Lys Gly Val Glu Asn Ser Asp 65 70 75 80

Lys Ser Pro Asp Ala Lys Met Pro Glu Asp He Tyr Cys Lys Gin He

85 90 95

Thr Leu Glu Ser Met Leu Glu Thr Thr Asp Ala Phe Gin Ala Ser Cys

100 105 110

He Ala He Ala Leu Lys Ser Lys He Arg Asp Phe Asp Lys He Pro

115 120 125

He Gin Thr Phe Lys Pro Leu Gin Glu Lys He Lys Glu Ala Tyr Pro

130 135 140

He Leu Tyr Glu Glu Leu Glu He Leu Gin Ser Lys Asn Val Ser Ala 145 150 155 160

Ser Leu Phe Lys Ala Asn Ala Gin Val Phe Ser Ala Leu Phe Asn His 165 170 175

Leu Ser Tyr Glu Lys Lys Leu Gin He Phe Glu Lys His He Pro He

180 185 190

Lys Glu Leu Asn Arg Leu Leu Asp Glu Asp Tyr Pro Ala Phe Asn Arg

195 200 205

Leu He Tyr Gin Val He Leu Asp Pro Lys Leu Asp His Phe Lys Asp

210 215 220

Ala Leu Ala Lys Ser Asn Ala Thr Gin Ser Asn Ala Gin Thr Phe Phe 225 230 235 240

He Leu Gly He Asn Glu He Leu His Lys Lys Thr Ser Lys Ala Leu

245 250 255

Lys Tyr Phe Glu Arg Ser Glu Ala Val Val Lys Asp Asp Asp Phe Ser

260 265 270

Lys Asp Arg Ala He Phe Trp Gin Tyr Leu Ala Ser Lys Lys Lys Lys

275 280 285

Thr Leu Glu His Leu Ser Gin Ser Pro Ala Leu Asn Leu Tyr Ser Leu

290 295 300

Tyr Ala Ser Arg Lys Pro Gin Asn His Ala Gin Leu Ser His His Phe 305 310 315 320

Ser Tyr Pro Lys Phe Lys Pro Arg Glu Pro Ser Phe 325 330

(2) INFORMATION FOR SEQ ID NO: 889:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 157 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 157

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 889:

Val His Leu Ala His Tyr Leu Lys Arg Asn Phe Ser Phe Phe Pro Ser

1 5 10 15

Val Asp He Val Asp Gly Gly Thr Met Ala Gin Gin Leu He Pro Leu

20 25 30

He Thr Ser Tyr Glu Lys Val Leu He Leu Asp Cys Val Ser Ala Lys

35 40 45

Gly Val Glu He Gly Ser Val Tyr Ala Phe Asp Phe Lys Asp Ala Pro

50 55 60

Lys Glu He Thr Trp Ala Gly Ser Ala His Glu Val Glu Met Leu His 65 70 75 80

Thr Leu Arg Leu Thr Glu Phe Leu Gly Asp Leu Pro Lys Thr Phe He

85 90 95

Val Gly Leu Val Pro Phe Val He Gly Ser Glu Thr Thr Phe Lys Leu

100 105 110

Ser Ser Glu Met Leu Asn Ala Leu Glu Thr Ala Leu Lys Ala He Glu 115 120 125

Thr Gin Leu Asn Ala Trp Gly Val Lys Met Gin Arg Thr Asp His He

130 135 140

Ala Leu Asp Cys He Ala Glu Leu Ser Tyr Lys Gly Phe 145 150 155

(2) INFORMATION FOR SEQ ID NO: 890:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 307 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...307

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 890:

Met Lys Lys Val Leu Leu Leu Thr Leu Ser Leu Ser Leu Ser Phe Trp

1 5 10 15

Leu His Ala Glu Arg Asn Gly Phe Tyr Leu Gly Leu Asn Phe Ala Glu

20 25 30

Gly Ser Tyr He Gin Gly Gin Gly Ser He Gly Glu Lys Ala Ser Ala

35 40 45

Glu Asn Ala Leu Asn Gin Ala He Asn Asn Ala Lys Asn Ser Leu Phe

50 55 60

Pro Asn Thr Lys Ala He Arg Asp Val Gin Asn Ala Leu Asn Ala Val 65 70 75 80

Lys Asp Ser Asn Lys He Ala Asn Arg Phe Ala Gly Asn Gly Gly Ser

85 90 95

Gly Gly He Phe Asn Glu Leu Ser Leu Gly Tyr Lys Tyr Phe Leu Gly

100 105 110

Lys Lys Arg He He Gly Phe Arg His Ser Leu Phe Phe Gly Tyr Gin

115 120 125

Leu Gly Gly Val Gly Ser Val Pro Gly Ser Gly Leu He Ala Phe Leu

130 135 140

Pro Tyr Gly Phe Asn Thr Asp Leu Leu He Asn Trp Thr Asn Asp Lys 145 150 155 160

Arg Ala Ser Gin Glu Tyr Val Glu Arg Arg Val Lys Gly Leu Ser He

165 170 175

Phe Tyr Lys Asp Met Thr Gly Arg Thr Leu Asp Ala Asp Thr Leu Lys

180 185 190

Arg Ala Ser Arg His He He Arg Lys Ser Ser Gly Leu Val He Gly

195 200 205

Met Glu Leu Gly Ala Ser Thr Trp Phe Ala Ser Asn Asn Leu Thr Pro

210 215 220

Phe Asn Gin Val Lys Ser Arg Thr He Phe Gin Leu Gin Gly Lys Phe 225 230 235 240

Gly Val Arg Phe Ser Ser Asp Glu Tyr Asp He Asp Arg Tyr Gly Asp 245 250 255

Glu Asn Tyr Leu Gly Gly Ser Ser Val Glu Leu Gly Val Lys Val Pro

260 265 270

Ala Phe Lys Val Asn Tyr Tyr Ser Asp Asp Tyr Gly Asp Lys Leu Asp

275 280 285

Tyr Lys Arg Val Val Ser Val Tyr Leu Asn Tyr Thr Tyr Asn Phe Lys

290 295 300 305

(2) INFORMATION FOR SEQ ID NO: 891:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 578 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...578

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 891 :

Met Ser Lys Lys He Val Val Asp Pro He Thr Arg He Glu Gly His

1 5 10 15

Leu Arg He Glu Val He Val Asp Asp Asp Asn Val He Thr Asp Ala

20 25 30

Phe Ser Ser Ser Thr Leu Phe Arg Gly Leu Glu Thr He He Lys Gly

35 40 45

Arg Asp Pro Arg Asp Ala Gly Phe He Ala Gin Arg He Cys Gly Val

50 55 60

Cys Thr Tyr Ser His Tyr Lys Ala Gly Val Thr Ala Val Glu Asn Ala 65 70 75 80

Leu Gly He Thr Pro Pro Leu Asn Ala Gin Leu Val Arg Ser Leu Met

85 90 95

Asn Met Ala Leu Leu Phe His Asp His Val Val His Phe Tyr Thr Leu

100 105 110

His Gly Leu Asp Trp Cys Asp He Leu Ser Thr Leu Lys Ala Asp Pro

115 120 125

He Gin Ala Ala Lys Leu Ser Phe Lys Tyr Ser Pro Tyr Pro He Asn

130 135 140

Thr Gly Ala Gly Glu Leu Lys Ala Val Gin Lys Arg Leu Asn Asp Phe 145 150 155 160

Ala Lys Ser Gly Ser Leu Gly Pro Phe Ser Asn Gly Tyr Tyr Gly His

165 170 175

Lys Thr Tyr Arg Leu Asn Pro Glu Gin Asn Leu He Val Leu Ser His

180 185 190

Tyr Leu Lys Leu Leu Glu He Gin Arg Glu Ala Ala Lys Met Thr Ala

195 200 205

He Phe Gly Ala Lys Gin Pro His Pro Gin Ser Leu Thr Val Gly Gly 210 215 220

Val Thr Ser Val Met Asp He Leu Asp Pro Thr Arg Leu Ala Glu Trp 225 230 235 240

Lys Ser Lys Phe Glu Val Val Ala Asn Phe He Asn His Ala Tyr Tyr

245 250 255

Pro Asp Leu Val Met Ala Gly Glu Met Phe Ala Asn Glu Pro Ser Val

260 265 270

He Lys Gly Cys Gly Leu Arg Asn Phe He Ala Tyr Glu Glu Val Leu

275 280 285

Leu Gly Lys Asp Lys Tyr Leu Leu Ser Ser Gly Val Val Leu Asp Gly

290 295 300

Asp He Ser Lys Leu His Pro He Asp Glu Ser Leu He Lys Glu Glu 305 310 315 320

Val Thr His Ser Trp Tyr Gin Tyr Glu Asp Thr Lys Glu Val Gin Leu

325 330 335

His Pro Tyr Asp Gly Gin Thr Asn Pro His Tyr Thr Gly Leu Lys Asp

340 345 350

Gly Glu Ser Val Gly He Glu Asn Lys He He Pro Ala Lys Val Leu

355 360 365

Asp Thr Lys Asp Lys Tyr Ser Trp He Lys Ser Pro Arg Tyr Asp Ser

370 375 380

Lys Pro Met Glu Val Gly Pro Leu Ser Ser Val Val Val Gly Leu Ala 385 390 395 400

Ala Lys Asn Pro Tyr Val Thr Glu Val Ala Thr Lys Phe Leu Lys Asp

405 410 415

Thr Lys Leu Pro Leu Glu Ala Leu Phe Ser Thr Leu Gly Arg Thr Ala

420 425 430

Ala Arg Cys He Glu Ala Lys Thr He Ala Asp Asn Gly Leu Leu Ala

435 440 445

Phe Asp Ala Leu Val Glu Asn Leu Lys Ser Asp Gin Ser Thr Cys Ala

450 455 460

Pro Tyr His He Asp Lys Asn Gin Glu Tyr Lys Gly Arg Tyr He Gly 465 470 475 480

Gin Val Pro Arg Gly Met Leu Ser His Trp Val Arg He Lys Asn Gly

485 490 495

Val Val Glu Asn Tyr Gin Ala Val Val Pro Ser Thr Trp Asn Ala Gly

500 505 510

Pro Arg Asp Ser Lys Asn Gin Arg Gly Ala Tyr Glu Met Ser Leu He

515 520 525

Gly Thr Lys He Ala Asp Leu Thr Gin Pro Leu Glu He He Arg Thr

530 535 540

He His Ser Phe Asp Pro Cys He Ala Cys Ser Val His Val Met Asp 545 550 555 560

Phe Lys Gly Gin Ser Leu Asn Glu Phe Lys Val Glu Pro Asn Phe Ala

565 570 575

Lys Phe

12) INFORMATION FOR SEQ ID NO: 892:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 68 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein (ill) HYPOTHETICAL: YES

(v ) ORIGINAL SOURCE.

(A) ORGANISM Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...68

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 892 :

Met Asn Ser Ser Asn Leu Lys Asn Trp Leu Phe Pro Thr He Cys Phe

1 5 10 15

Phe Leu Phe Cys Tyr He Leu He Phe Leu He Phe Phe Met Phe Lys

20 25 30

Asn Leu Gin Ser Gin Ser Phe Gly Ser Val Ala Glu Thr Gly Lys Lys

35 40 45

Pro He Thr Thr Thr Lys Lys Phe Gly Lys Glu Leu Gin Lys Gin He

50 55 60

Ser Lys He His 65

(2) INFORMATION FOR SEQ ID NO: 893:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 53 ammo acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...53

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 893 :

Val Val Leu Pro Lys Glu Thr Leu Ser Ser He Ala Lys Arg Tyr Gin

1 5 10 15

Val Ser He Ser Ser He Gin Leu Ala Asn Asn Leu Lys Asp Ser Asn

20 25 30

He Phe He His Gin Arg Leu He He Pro Thr Asn Lys Lys Leu Leu

35 40 45

Ala Thr Arg Glu Phe 50

(2) INFORMATION FOR SEQ ID NO: 894:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 352 ammo acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...352

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 894:

Leu Tyr Phe Leu Asn Gly Gly Tyr Asn Arg Leu His Lys Ser Tyr Glu

1 5 10 15

Arg He Val Met Leu He Ala Arg Phe Lys Lys Ala Leu He Ser Tyr

20 25 30

Ser Leu Gly Val Leu Leu Val Ser Ser Leu Leu Gly Val Ala Asn Ala

35 40 45

Ser Asn Gin Glu He Gin Val Lys Asp Tyr Phe Gly Glu Gin Thr He

50 55 . 60

Lys Leu Pro Val Ser Lys He He Tyr Leu Gly Ser Phe Ala Glu Val 65 70 75 80

Pro Ala Met Phe Asn Thr Trp Asp Arg Val Val Gly He Ser Asp Tyr

85 90 95

Ala Phe Lys Ser Asp He Val Lys Ala Thr Leu Lys Asp Pro Glu Arg

100 105 110

He Lys Pro Met Ser Ser Asp His Val Ala Ala Leu Asn Val Glu Leu

115 120 125

Leu Lys Lys Leu Ser Pro Asp Leu Val Val Thr Phe Val Gly Asn Pro

130 135 140

Lys Ala Val Glu His Ala Lys Lys Phe Gly He Ser Phe Leu Ser Phe 145 150 155 160

Gin Glu Lys Thr He Val Glu Val Met Glu Asp He Asp Ala Gin Ala

165 170 175

Lys Ala Leu Glu Val Asp Ala Ser Lys Lys Leu Ala Lys Met Gin Glu

180 185 190

Thr Leu Asp Phe He Lys Glu Arg Leu Lys Asn Val Lys Lys Lys Lys

195 200 205

Gly Val Glu Leu Phe His Lys Ala Asn Lys He Ser Gly His Gin Ala

210 215 220

Leu Asp Ser Asp He Leu Glu Lys Gly Gly He Asp Asn Phe Gly Leu 225 230 235 240

Lys Tyr Val Lys Phe Gly Arg Ala Asp He Ser Val Glu Lys He Val

245 250 255

Lys Glu Asn Pro Glu He He Phe He Trp Trp He Ser Pro Leu Ser

260 265 270

Pro Glu Asp Val Leu Asn Asn Pro Lys Phe Ser Thr He Lys Ala He

275 280 285

Lys Asn Lys Gin Val Tyr Lys Leu Pro Thr Met Asp He Gly Gly Pro

290 295 300

Arg Ala Pro Leu He Ser Leu Phe He Ala Leu Lys Ala His Pro Glu 305 310 315 320

Ala Phe Lys Gly Val Asp He Asn Ala He He Lys Asp Tyr Tyr Lys

325 330 335

Val Val Phe Asp Leu Asn Asp Ala Glu Val Glu Pro Phe Leu Trp His 340 345 350

(2) INFORMATION FOR SEQ ID NO 895

(l) SEQUENCE CHARACTERISTICS

(A) LENGTH 197 ammo acids (3) TYPE- ammo acid (D) TOPOLOGY, linear

(n) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...197

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 895:

Met Lys Cys Ser Ser Phe Thr Ser Asn Ser Val Leu Asn Phe Phe Val

1 5 10 15

Val Leu Ser Phe He Thr He Gly Leu Val Phe Phe Phe Leu Arg Ser

20 25 30

Gin Pro Thr Ser Val Val Ser Lys Glu Asn He Pro Lys He Glu Leu

35 40 45

Glu Asn Phe Lys Ala Phe Gin He Asn Asp Lys He Leu Asp Leu Ser

50 55 60

He Glu Gly Lys Lys Ala Leu Gin Tyr Asp Asp His Glu He Phe Phe 65 70 75 80

Asp Ser Lys He Lys Arg Tyr Asp Glu Asp Thr He Glu Ser Val Glu

85 90 95

Ser Pro Glu Ala Lys Arg Gin Gin Asp Leu Tyr Phe Phe Pro Asn Gly

100 105 110

Val Thr Tyr Lys Arg Ser Asp Asp Ser Ser Phe Trp Ser Glu Thr Gly

115 120 125

He Tyr Asn His Lys Glu Gin Asn Phe Lys Gly Lys Gly Arg Phe He

130 135 140

Leu Thr Ser Lys Asp Ser Lys Val Glu Gly Leu Asp He Ser Tyr Ser 145 150 155 160

His Ala Leu Ala He He Glu Ala Gin Ser He Gin Ala Asn Leu Phe

165 170 175

Leu Asp Glu He Lys Gin Ser Gin Lys Glu Lys Lys Lys Phe Pro Thr

180 185 190

Phe Lys Gly Gly Phe 195

(2) INFORMATION FOR SEQ ID NO : 896-

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 185 ammo acids

(D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein (ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE.

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE.

( A ) NAME / KEY : mi scjeature

( B ) LOCATION 1 . . . 185

(xi) SEQUENCE DESCRIPTION- SEQ ID NO: 896:

Met Arg Trp Trp Cys Phe Leu Val Cys Cys Leu Ser Val Leu Ser Val

1 5 10 15

Met Asp Ala Lys Lys Leu Glu Asn Lys Gly Leu Lys Lys Glu Arg Glu

20 25 30

Leu Leu Glu He Thr Gly Asn Gin Phe Val Ala Asn Asp Lys Thr Lys

35 40 45

Thr Ala Val He Gin Gly Asn Val Gin He Lys Lys Gly Lys Asp Arg

50 55 60

Leu Phe Ala Asp Lys Val Ser Val Phe Leu Asn Asp Lys Arg Lys Pro 65 70 75 80

Glu Arg Tyr Glu Ala Thr Gly Asn Thr His Phe Asn He Phe Thr Glu

85 90 95

Asp Asn Arg Glu He Ser Gly Ser Thr Asp Lys Leu He Tyr Asn Ala

100 105 110

Leu Asn Gly Glu Tyr Lys Leu Leu Gin Asn Ala Val Val Arg Glu Val

115 120 125

Gly Lys Ser Asn Val He Thr Gly Asp Glu He He Leu Asn Lys Thr

130 135 140

Lys Gly Tyr Ala Asp Val Leu Gly Ser Ala Lys Arg Pro Ala Lys Phe 145 150 155 160

Val Phe Asp Met Glu Asp He Asn Glu Glu Asn Arg Lys Ala Lys Leu

165 170 175

Lys Lys Lys Gly Ala Lys Glu Lys Pro 180 185

(2) INFORMATION FOR SEQ ID NO: 897:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 211 ammo acids

(D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(m) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A ) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 211

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 897: Leu He Gin Gin Asn Phe Lys Thr Leu Lys Glu Leu Tyr Met Leu Val

1 5 10 15

Thr Lys Leu Ala Pro Asp Phe Lys Ala Pro Ala Val Leu Gly Asn Asn

20 25 30

Glu Val Asp Glu His Phe Glu Leu Ser Lys Asn Leu Gly Lys Asn Gly

35 40 45

Val He Leu Phe Phe Trp Pro Lys Asp Phe Thr Phe Val Cys Pro Thr

50 55 60

Glu He He Ala Phe Asp Lys Arg Val Lys Asp Phe His Glu Lys Gly 65 70 75 80

Phe Asn Val He Gly Val Ser He Asp Ser Glu Gin Val His Phe Ala

85 90 95

Trp Lys Asn Thr Pro Val Glu Lys Gly Gly He Gly Gin Val Ser Phe

100 105 110

Pro Met Val Ala Asp He Thr Lys Ser He Ser Arg Asp Tyr Asp Val

115 120 125

Leu Phe Glu Glu Ala He Ala Leu Arg Gly Ala Phe Leu He Asp Lys

130 135 140

Asn Met Lys Val Arg His Ala Val He Asn Asp Leu Pro Leu Gly Arg 145 150 155 160

Asn Ala Asp Glu Met Leu Arg Met Val Asp Ala Leu Leu His Phe Glu

165 170 175

Glu His Gly Glu Val Cys Pro Ala Gly Trp Arg Lys Gly Asp Lys Gly

180 185 190

Met Lys Ala Thr His Gin Gly Val Ala Glu Tyr Leu Lys Glu Asn Ser

195 200 205

He Lys Leu 210

(2) INFORMATION FOR SEQ ID NO: 898:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 196 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...196

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 898 :

Val Pro Leu Trp He Met Val Val Gly Ala Ala Gly He Ala Leu Gly

1 5 10 15

Leu Ser Leu Tyr Gly Pro Lys Leu He Lys Thr Val Gly Ser Glu He

20 25 30

Thr Glu Leu Asp Lys Met Gin Ala Phe Cys He Ala Leu Ser Ala Val

35 40 45

He Thr Val Leu Leu Ala Ser Gin Leu Gly Leu Pro Val Ser Ser Thr 50 55 60 His He Val Val Gly Ala Val Phe Gly Val Gly Phe Leu Arg Glu Arg 65 70 75 80

Leu Arg Glu Gin Ser Arg Arg Arg Phe Ala Arg He Arg Asp Asn He

85 90 95

Val Ala Ala His Phe Gly Glu Asp Leu Glu Glu He Glu Gly Phe Leu

100 105 110

Glu Arg Phe Asp Lys Ala Asn Leu Lys Glu Lys Ser Leu Met Leu Glu

115 120 125

Ser Leu Lys Lys Ser Lys Asn Thr Ala He Ala Leu Glu Leu Lys Lys

130 135 140

Lys Glu Lys Lys Ser Leu Lys Lys Val Tyr Lys Glu Glu Val He Lys 145 150 155 160

Arg Ser He Leu Lys Lys He Val Thr Ala Trp Leu Val Thr Val Pro

165 170 175

Val Ser Ala Leu Leu Gly Ala Leu Leu Phe Val Ala Leu Gly Phe He

180 185 190

Glu Lys Tyr Phe 195

(2) INFORMATION FOR SEQ ID NO: 899:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 174 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...174

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 899 :

Met Ser Asn Ser Met Leu Asp Lys Asn Lys Ala He Leu Thr Gly Gly

1 5 10 15

Gly Ala Leu Leu Leu Gly Leu He Val Leu Phe Tyr Leu Ala Tyr Arg

20 25 30

Pro Lys Ala Glu Val Leu Gin Gly Phe Leu Glu Ala Arg Glu Tyr Ser

35 40 45

Val Ser Ser Lys Val Pro Gly Arg He Glu Lys Val Phe Val Lys Lys

50 55 60

Gly Asp Arg He Lys Lys Gly Asp Leu Val Phe Ser He Ser Ser Pro 65 70 75 80

Glu Leu Glu Ala Lys Leu Ala Gin Ala Glu Ala Gly His Lys Ala Ala

85 90 95

Lys Ala Val Ser Asp Glu Val Lys Arg Gly Ser Arg Asp Glu Thr He

100 105 110

Asn Ser Ala Arg Asp Val Trp Gin Ala Ala Lys Ser Gin Ala Asn Leu

115 120 125

Ala Lys Glu Thr Tyr Lys Arg Val Gin Asp Leu Tyr Asp Asn Gly Val 130 135 140 Ala Ser Leu Gin Lys Arg Asp Glu Ala Tyr Ala Ala Met Lys Ala Pro 145 150 155 160

Asn Thr Thr Arg Ala Arg Leu Thr Lys Ser He Lys Trp Leu 165 170

(2) INFORMATION FOR SEQ ID NO:900:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 148 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A ) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 148

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 900:

Met Glu Phe Leu Ser Gly Tyr Phe Leu Trp Val Lys Ala Phe His Val

1 5 10 15

He Ala Val He Ser Trp Met Ala Ala Leu Phe Tyr Leu Pro Arg Leu

20 25 30

Phe Val Tyr His Ala Glu Asn Ala His Lys Lys Glu Phe Val Gly Val

35 40 45

Val Gin He Gin Glu Lys Lys Leu Tyr Ser Phe He Ala Ser Pro Ala

50 55 60

Met Gly Phe Thr Leu He Thr Gly He Leu Met Leu Leu He Ala Pro 65 70 75 80

Glu Met Phe Lys Ser Gly Gly Trp Leu His Ala Lys Leu Ala Leu Val

85 90 95

Val Leu Leu Leu He Tyr His Phe Tyr Cys Lys Lys Cys Met Arg Glu

100 105 110

Leu Glu Lys Asp Pro Thr Gly Lys Asn Ala Arg Phe Tyr Arg Val Phe

115 120 125

Asn Glu He Pro Thr He Leu Met He Leu He Val He Leu Val Val

130 135 140

Val Lys Pro Phe 145

(2) INFORMATION FOR SEQ ID NO: 901:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 145 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES (vi ) ORIGINAL SOURCE.

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...145

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 901 :

Met Lys Pro He Phe Leu Leu He Phe Leu Leu Leu Ala Ser Leu He

1 5 10 15

Ala Arg Glu Lys Asp Ala Ser Ser Asn Leu Phe Asp Leu He Asp Lys

20 25 30

Gly He Asn Arg Glu Gin Glu Leu Lys Glu Gin Glu Gin Lys Thr Arg

35 40 45

Leu Lys Leu Ala Gin Ser Pro Leu Val Ala Leu Glu He Val Pro Gin

50 55 60

Glu Thr Pro Tyr Leu Glu Trp Gin Gly Ala Arg Glu Ser Tyr Tyr Leu 65 70 75 80

Lys Val Ser Ala Val Val Glu Ser Val Val He Leu Lys He Asp He

85 90 95

Asn Gin Gly Arg Ser Cys Ser Leu Tyr Pro Thr Pro Lys Ser Val Ser

100 105 110

Leu Val Arg Asn Gin Ser Val Ala Tyr Glu He Leu Cys Glu Asn Gin

115 120 125

Pro Leu Trp He Glu Val Ser Thr Asn Leu Gly Lys Arg Thr Phe Gin

130 135 140

Phe 145

(2) INFORMATION FOR SEQ ID NO: 902:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 257 ammo acids

(D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...257

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 902:

Met Ala Lys Lys Asn Lys Pro Thr Glu Cys Pro Ala Gly Glu Lys Trp

1 5 10 15

Ala Val Pro Tyr Ala Asp Phe Leu Ser Leu Leu Leu Ala Leu Phe He

20 25 30

Ala Leu Tyr Ala He Ser Ala Val Asn Lys Ser Lys Val Glu Ala Leu

35 40 45

Lys Thr Glu Phe He Lys He Phe Asn Tyr Ala Pro Lys Pro Glu Ala 50 55 60

Met Gin Pro Val Val Val He Pro Pro Asp Ser Gly Lys Glu Glu Glu 65 70 75 80

Gin Met Ala Ser Glu Ser Ser Lys Pro Ala Ser Gin Asn Thr Glu Thr

85 90 95

Lys Ala Thr He Ala Arg Lys Gly Glu Gly Ser Val Leu Glu Gin He

100 105 110

Asp Gin Gly Ser Val Leu Lys Leu Pro Ser Ser Leu Leu Phe Glu Asn

115 120 125

Ala Thr Ser Asp Ala He Asn Gin Asp Met Met Leu Tyr He Glu Arg

130 135 140

He Ala Lys He He Gin Lys Leu Pro Lys Arg Val His He Asn Val 145 150 155 160

Arg Gly Phe Thr Asp Asn Thr Pro Leu Asn Lys Thr Arg Phe Lys Ser

165 170 175

His Tyr Glu Leu Ala Ala Asn Arg Ala Tyr Arg Val Met Lys Val Leu

180 185 190

He Gin Tyr Gly Val Asp Pro Asn Gin Leu Ser Phe Ser Ser Tyr Gly

195 200 205

Ser Thr Asn Pro He Ala Pro Asn Asp Ser Leu Glu Asn Arg Met Lys

210 215 220

Asn Asn Arg Val Glu He Phe Phe Ser Thr Asp Ala Asn Asp Leu Ser 225 230 235 240

Lys He His Ser He Leu Asp Glu Glu Phe Asn Pro His Lys Gin Gin

245 250 255

Glu

(2) INFORMATION FOR SEQ ID NO: 903:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 798 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...798

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 903 :

Met Arg Lys Val He He Met Asn Gly Tyr Leu Arg Val Lys Thr Pro

1 5 10 15

Tyr Phe Leu Ala Ser Val Val Leu Thr Phe Trp Thr Phe Asn Ser Phe

20 25 30

Met Ser Ala Lys Asp Lys His His Phe Leu Lys Lys Val Thr Thr Thr

35 40 45

Glu Gin Lys Phe Ser Ser Ser Ala Pro He Ser Trp Gin Ser Glu Glu

50 55 60

Val Arg Asn Ser Thr Ser Ser Arg Thr Val He Ser Asn Lys Glu Leu 65 70 75 80

Lys Lys Thr Gly Asn Leu Asn He Glu Asn Ala Leu Gin Asn Val Pro

85 90 95

Gly He Gin He Arg Asp Ala Thr Gly Thr Gly Val Leu Pro Lys He

100 105 110

Ser Val Arg Gly Phe Gly Gly Gly Gly Asn Gly His Ser Asn Thr Asn

115 120 125

Met He Leu Val Asn Gly He Pro He Tyr Gly Ala Pro Tyr Ser Asn

130 135 140

He Glu Leu Ala He Phe Pro Val Thr Phe Gin Ser Val Asp Arg He 145 150 155 160

Asp Val He Lys Gly Gly Thr Ser Val Gin Tyr Gly Pro Asn Thr Phe

165 170 175

Gly Gly Val Val Asn Val He Thr Lys Glu He Pro Lys Glu Trp Glu

180 185 190

Asn Gin Ala Ala Glu Arg He Thr Phe Trp Gly Arg Ser Ser Asn Gly

195 200 205

Asn Phe Val Asp Pro Lys Glu Lys Gly Lys Pro Leu Ala Gin Thr Leu

210 215 220

Gly Asn Gin Met Leu Phe Asn Thr Tyr Gly Arg Thr Ala Gly Met Leu 225 230 235 240

Gly Lys Tyr He Gly He Ser Ala Gin Gly Asn Trp He Asn Gly Gin

245 250 255

Gly Phe Arg Gin Asn Ser Pro Thr Lys Val Gin Asn Tyr Leu Leu Asp

260 265 270

Ala He Tyr Lys He Asn Ala Thr Asn Thr Phe Lys Ala Tyr Tyr Gin

275 280 285

Tyr Tyr Gin Tyr Asn Ser Tyr His Pro Gly Thr Leu Ser Ala Gin Asp

290 295 300

Tyr Ala Tyr Asn Arg Phe He Asn Glu Arg Pro Asp Asn Gin Asp Gly 305 310 315 320

Gly Arg Ala Lys Arg Phe Gly He Val Tyr Gin Asn Tyr Phe Gly Asp

325 330 335

Pro Asp Arg Lys Val Gly Gly Asp Phe Lys Phe Thr Tyr Phe Thr His

340 345 350

Asp Met Ser Arg Asp Phe Gly Phe Ser Asn Gin Tyr Gin Ser Val Tyr

355 360 365

Met Ser Gly Gin Asn Lys He Leu Pro Phe Lys Gly Lys Gly Glu He

370 375 380

Ser Ala Lys Asn Pro Asn Cys Gly Leu Tyr Ser Tyr Ser Asp Thr Asn 385 390 395 400

Ser Pro Cys Trp Gin Phe Phe Asp Asn He Arg Arg Ser Val Val Asn

405 410 415

Ala Phe Glu Pro Lys Leu Asn Leu He Val Asn Thr Gly Lys Val Lys

420 425 430

Gin Thr Phe Asn Met Gly Met Arg Phe Leu Thr Glu Asp Leu Tyr Arg

435 440 445

Arg Ser Thr Thr Arg Lys Asn Pro Ser Met Pro Asn Asn Gly Ser Gly

450 455 460

Phe Asp Ala Gly Thr Ser Leu Asn Asn Phe Asn Asn Tyr Thr Ala Val 465 470 475 480

Tyr Ala Ser Asp Glu He Asn Phe Asn Asn Gly Met Leu Thr He Thr

485 490 495

Pro Gly Leu Arg Tyr Thr Phe Leu Asn Tyr Glu Lys Lys Asp Ala Pro

500 505 510

Pro Phe Lys Val Gly Gin Thr Pro Lys Thr Thr Lys Glu Arg Tyr Asn 515 520 525 Gin Trp Asn Pro Ala Val Asn Val Gly Tyr Lys Pro He Lys Glu Leu

530 535 540

Leu Phe Tyr Phe Asn Tyr Gin Arg Ser Tyr He Pro Pro Gin Phe Ser 545 550 555 560

Asn He Gly Asn Phe Val Gly Thr Ser Thr Asp Tyr Phe Gin He Phe

565 570 575

Asn Val Met Glu Gly Gly Ser Arg Tyr Tyr Phe Asn His Gin Val Ser

580 585 590

Phe Asn Ala Asn Tyr Phe Val He Phe Ala Asn His Tyr Phe Thr Gly

595 600 605

Arg Tyr Gly Asp Asn Arg Glu Pro Val Asn Ala Arg Ser Gin Gly Val

610 615 620

Glu Leu Glu Leu Tyr Tyr Thr Pro He Arg Gly Leu Asn Phe His Ala 625 630 635 640

Ala Tyr Thr Phe He Asp Ala Asn He Thr Ser His Thr Met Val Thr

645 650 655

Asn Pro Ala Asn Pro Lys Gly Pro Lys Lys Asp He Phe Gly Lys Lys

660 665 670

Leu Pro Phe Val Ser Pro His Gin Phe He Leu Asp Ala Ser Tyr Thr

675 680 685

Tyr Ala Lys Thr Thr He Gly Leu Ser Ser Phe Phe Tyr Ser Arg Ala

690 695 700

Tyr Ser Asp Val Leu Asn Thr Val Pro Phe Thr Glu Tyr Ala Pro Thr 705 710 715 720

He Lys Asn Gly Ala He Val Thr Lys Thr Ala Gly Met Thr Pro Tyr

725 730 735

Tyr Trp Val Trp Asn Leu Gin He Ser Thr Thr Leu Trp Glu Arg Lys

740 745 750

Asn Gin Ser Val Asn Ala Ser Leu Gin He Asn Asn He Phe Asn Met

755 760 765

Lys Tyr Trp Phe Ser Gly He Gly Thr Ser Pro Asn Gly Lys Glu Ala

770 775 780

Ala Pro Pro Arg Ser He Thr Ala Tyr Val Ser Tyr Asn Phe 785 790 795

(2) INFORMATION FOR SEQ ID NO: 904:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 798 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...798

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 904:

Met Arg Lys Val He He Met Asn Gly Tyr Leu Arg Val Lys Thr Pro 1 5 10 15 Tyr Phe Leu Ala Ser Val Val Leu Thr Phe Trp Thr Phe Asn Ser Phe

20 25 30

Met Ser Ala Lys Asp Lys His His Phe Leu Lys Lys Val Thr Thr Thr

35 40 45

Glu Gin Lys Phe Ser Ser Ser Ala Pro He Ser Trp Gin Ser Glu Glu

50 55 60

Val Arg Asn Ser Thr Ser Ser Arg Thr Val He Ser Asn Lys Glu Leu 65 70 75 80

Lys Lys Thr Gly Asn Leu Asn He Glu Asn Ala Leu Gin Asn Val Pro

85 90 95

Gly He Gin He Arg Asp Ala Thr Gly Thr Gly Val Leu Pro Lys He

100 105 110

Ser Val Arg Gly Phe Gly Gly Gly Gly Asn Gly His Ser Asn Thr Asn

115 120 125

Met He Leu Val Asn Gly He Pro He Tyr Gly Ala Pro Tyr Ser Asn

130 135 140

He Glu Leu Ala He Phe Pro Val Thr Phe Gin Ser Val Asp Arg He 145 150 155 160

Asp Val He Lys Gly Gly Thr Ser Val Gin Tyr Gly Pro Asn Thr Phe

165 170 175

Gly Gly Val Val Asn Val He Thr Lys Glu He Pro Lys Glu Trp Glu

180 185 190

Asn Gin Ala Ala Glu Arg He Thr Phe Trp Gly Arg Ser Ser Asn Gly

195 200 205

Asn Phe Val Asp Pro Lys Glu Lys Gly Lys Pro Leu Ala Gin Thr Leu

210 215 220

Gly Asn Gin Met Leu Phe Asn Thr Tyr Gly Arg Thr Ala Gly Met Leu 225 230 235 240

Gly Lys Tyr He Gly He Ser Ala Gin Gly Asn Trp He Asn Gly Gin

245 250 255

Gly Phe Arg Gin Asn Ser Pro Thr Lys Val Gin Asn Tyr Leu Leu Asp

260 265 270

Ala He Tyr Lys He Asn Ala Thr Asn Thr Phe Lys Ala Tyr Tyr Gin

275 280 285

Tyr Tyr Gin Tyr Asn Ser Tyr His Pro Gly Thr Leu Ser Ala Gin Asp

290 295 300

Tyr Ala Tyr Asn Arg Phe He Asn Glu Arg Pro Asp Asn Gin Asp Gly 305 310 315 320

Gly Arg Ala Lys Arg Phe Gly He Val Tyr Gin Asn Tyr Phe Gly Asp

325 330 335

Pro Asp Arg Lys Val Gly Gly Asp Phe Lys Phe Thr Tyr Phe Thr His

340 345 350

Asp Met Ser Arg Asp Phe Gly Phe Ser Asn Gin Tyr Gin Ser Val Tyr

355 360 365

Met Ser Gly Gin Asn Lys He Leu Pro Phe Lys Gly Lys Gly Glu He

370 375 380

Ser Ala Lys Asn Pro Asn Cys Gly Leu Tyr Ser Tyr Ser Asp Thr Asn 385 390 395 400

Ser Pro Cys Trp Gin Phe Phe Asp Asn He Arg Arg Ser Val Val Asn

405 410 415

Ala Phe Glu Pro Lys Leu Asn Leu He Val Asn Thr Gly Lys Val Lys

420 425 430

Gin Thr Phe Asn Met Gly Met Arg Phe Leu Thr Glu Asp Leu Tyr Arg

435 440 445

Arg Ser Thr Thr Arg Lys Asn Pro Ser Met Pro Asn Asn Gly Ser Gly

450 455 460

Phe Asp Ala Gly Thr Ser Leu Asn Asn Phe Asn Asn Tyr Thr Ala Val 465 470 475 480

Tyr Ala Ser Asp Glu He Asn Phe Asn Asn Gly Met Leu Thr He Thr

485 490 495

Pro Gly Leu Arg Tyr Thr Phe Leu Asn Tyr Glu Lys Lys Asp Ala Pro

500 505 510

Pro Phe Lys Val Gly Gin Thr Pro Lys Thr Thr Lys Glu Arg Tyr Asn

515 520 525

Gin Trp Asn Pro Ala Val Asn Val Gly Tyr Lys Pro He Lys Glu Leu

530 535 540

Leu Phe Tyr Phe Asn Tyr Gin Arg Ser Tyr He Pro Pro Gin Phe Ser 545 550 555 560

Asn He Gly Asn Phe Val Gly Thr Ser Thr Asp Tyr Phe Gin He Phe

565 570 575

Asn Val Met Glu Gly Gly Ser Arg Tyr Tyr Phe Asn His Gin Val Ser

580 585 590

Phe Asn Ala Asn Tyr Phe Val He Phe Ala Asn His Tyr Phe Thr Gly

595 600 605

Arg Tyr Gly Asp Asn Arg Glu Pro Val Asn Ala Arg Ser Gin Gly Val

610 615 620

Glu Leu Glu Leu Tyr Tyr Thr Pro He Arg Gly Leu Asn Phe His Ala 625 630 635 640

Ala Tyr Thr Phe He Asp Ala Asn He Thr Ser His Thr Met Val Thr

645 650 655

Asn Pro Ala Asn Pro Lys Gly Pro Lys Lys Asp He Phe Gly Lys Lys

660 665 670

Leu Pro Phe Val Ser Pro His Gin Phe He Leu Asp Ala Ser Tyr Thr

675 680 685

Tyr Ala Lys Thr Thr He Gly Leu Ser Ser Phe Phe Tyr Ser Arg Ala

690 695 700

Tyr Ser Asp Val Leu Asn Thr Val Pro Phe Thr Glu Tyr Ala Pro Thr 705 710 715 720

He Lys Asn Gly Ala He Val Thr Lys Thr Ala Gly Met Thr Pro Tyr

725 730 735

Tyr Trp Val Trp Asn Leu Gin He Ser Thr Thr Leu Trp Glu Arg Lys

740 745 750

Asn Gin Ser Val Asn Ala Ser Leu Gin He Asn Asn He Phe Asn Met

755 760 765

Lys Tyr Trp Phe Ser Gly He Gly Thr Ser Pro Asn Gly Lys Glu Ala

770 775 780

Ala Pro Pro Arg Ser He Thr Ala Tyr Val Ser Tyr Asn Phe 785 790 795

(2) INFORMATION FOR SEQ ID NO: 905:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 277 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE: (A) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 277

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 905:

Met Lys Thr Asn Gly Leu Phe Lys Met Trp Gly Leu Phe Leu Val Leu

1 5 10 15

He Ala Leu Val Phe Asn Ala Cys Ser Asp Ser His Lys Glu Lys Lys

20 25 30

Asp Ala Leu Glu Val He Lys Gin Arg Gly Val Leu Lys Val Gly Val

35 40 45

Phe Ser Asp Lys Pro Pro Phe Gly Ser Val Asp Ser Lys Gly Asn Tyr

50 55 60

Gin Gly Tyr Asp Val Val He Ala Lys Arg Met Ala Leu Asp Leu Leu 65 70 75 80

Gly Asp Glu Asn Lys He Glu Phe He Pro Val Glu Ala Ser Ala Arg

85 90 95

Val Glu Phe Leu Lys Ala Asn Lys Val Asp He He Met Ala Asn Phe

100 105 110

Thr Arg Thr Lys Glu Arg Glu Lys Val Val Asp Phe Ala Asn Pro Tyr

115 120 125

Met Lys Val Ala Leu Gly Val He Ser Lys Asp Gly Val He Lys Asn

130 135 140

He Glu Glu Leu Lys Asp Lys Glu Leu He Val Asn Lys Gly Thr Thr 145 150 155 160

Ala Asp Phe Tyr Phe Thr Lys Asn Tyr Pro Asn He Lys Leu Leu Lys

165 170 175

Phe Glu Gin Asn Thr Glu Thr Phe Leu Ala Leu Leu Asn Asn Lys Ala

180 185 190

He Ala Leu Ala His Asp Asn Thr Leu Leu Leu Ala Trp Val Lys Gin

195 200 205

His Pro Glu Phe Lys Leu Gly He Thr Ser Leu Gly Asp Lys Asp Val

210 215 220

He Ala Pro Ala He Lys Lys Gly Asn Pro Lys Leu Leu Glu Trp Leu 225 230 235 240

Asn Asn Glu He Asp Ser Leu He Ser Ser Asp Phe Leu Lys Glu Ala

245 250 255

Tyr Gin Glu Thr Leu Glu Pro He Tyr Gly Asp Gly He Lys Pro Glu

260 265 270

Glu He He Phe Glu 275

(2) INFORMATION FOR SEQ ID NO: 906:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 207 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE: (A) NAME/KEY: miscjeature

(B) LOCATION 1...207

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 906 :

Leu Asp Asn Phe He Ser Gin Tyr Ala Gin Arg Leu He Val Thr Asn

1 5 10 15

Leu Ser Gin Ala He Arg He Tyr Gly Tyr Glu Val Gly Gly Thr Phe

20 25 30

Arg Tyr Lys Gly Val Ser Leu Asn Val Gly He Ser Arg Thr Trp Pro

35 40 45

Thr Thr Arg Gly Tyr Leu Met Ala Asp Ser Tyr Glu Leu Ala Ala Ser

50 55 60

Thr Gly Asn Val Phe He He Lys Leu Asp Tyr Thr He Pro Lys Thr 65 70 75 80

Gly He Asn Leu Ala Trp Leu Ser Arg Phe Val Thr Gly Leu Asp Tyr

85 90 95

Cys Gly Phe Asp He Tyr Leu Pro Asp Tyr Gly Thr Ala Glu Lys Pro

100 105 110

Lys Thr Pro Thr Asp Leu Ala Lys Cys Gly Ser Gin Leu Gly Leu Val

115 120 125

His Met His Lys Pro Gly Tyr Gly Val Ser Asn Phe Tyr He Asn Trp

130 135 140

Ser Pro Lys Thr Lys Ser His Trp Lys Gly Leu Leu Leu Ser Ala Val 145 150 155 160

Phe Asn Asn Val Phe Asn Lys Phe Tyr Val Asp Gin Thr Ser Pro Tyr

165 170 175

Val Met Ser Pro Asp Met Pro Gly Thr Asp Ala He Lys Arg Ala He

180 185 190

Ala Glu Pro Gly Phe Asn Ala Arg Phe Glu Val Ala Tyr Lys Trp 195 200 205

(2) INFORMATION FOR SEQ ID NO: 907:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 244 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...244

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 907 :

Met Lys Lys Ala Gly Phe Leu Phe Leu Ala Ala Met Ala He He Val

1 5 10 15

Val Ser Leu Asn Ala Lys Asp Pro Asn Val Leu Arg Lys He Val Phe

20 25 30

Glu Lys Cys Leu Pro Asn Tyr Glu Lys Asn Gin Asn Pro Ser Pro Cys 35 40 45

He Glu Val Lys Pro Asp Ala Gly Tyr Val Val Leu Lys Asp He Asn

50 55 60

Gly Pro Leu Gin Tyr Leu Leu Met Pro Thr Thr His He Ser Gly He 65 70 75 80

Glu Asn Pro Leu Leu Leu Asp Pro Ser Thr Pro Asn Phe Phe Tyr Leu

85 90 95

Ser Trp Gin Ala Arg Asp Phe Met Ser Lys Lys Tyr Gly Lys Pro He

100 105 110

Pro Asp Tyr Ala He Ser Leu Thr He Asn Ser Lys Lys Gly Arg Ser

115 120 125

Gin Asn His Phe His He His He Ser Cys He Ser Leu Asp Val Arg

130 135 140

Lys Gin Leu Asp Asn Asn Leu Lys Asn He Asn Ser Arg Trp Ser Pro 145 150 155 160

Leu Ser Gly Gly Leu Asn Gly His Lys Tyr Leu Ala Arg Arg Val Thr

165 170 175

Glu Ser Glu Leu Ala Gin Lys Ser Pro Phe Val Met Leu Ala Lys Glu

180 185 190

Val Pro Asn Ala His Lys Arg Met Gly Asp Tyr Gly Leu Ala Val Val

195 200 205

Gin Gin Ser Asp Asn Ser Phe Val Leu Leu Ala Thr Gin Phe Asn Pro

210 215 220

Leu Thr Leu Asn Arg Ala Ser Ala Glu Glu He Gin Asp His Glu Cys 225 230 235 240

Ala He Leu Arg

(2) INFORMATION FOR SEQ ID NO: 908:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 228 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...228

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 908:

Met Val Phe Asp Arg Thr Thr Ser Val Arg Glu Lys Lys Ala Ala Lys

1 5 10 15

Ala Leu Gly He Val Gly He Val Phe Phe He Leu Phe Gly He Val

20 25 30

He Ser Gly Val Ala Ser Gin Lys Glu Trp Val Gin Gin Leu Asp Leu

35 40 45

Phe Phe He Asp Leu He Arg Asn Pro Ala Pro He Gin Gly Ser Thr

50 55 60

Trp Leu Ser Phe Val Phe Phe Ser Thr Trp Phe Ala Gin Ser Lys Leu 65 70 75 80

Thr Thr Pro He Ala Leu Leu He Gly Leu Trp Phe Gly Phe Gin Lys

85 90 95

Arg He Ala Leu Gly Val Trp Phe Phe Phe Ser He Leu Leu Gly Glu

100 105 110

Phe Thr Leu Lys Ser Leu Lys Leu Leu Val Ala Arg Pro Arg Pro Val

115 120 125

Thr Asn Gly Glu Leu Val Phe Ala His Gly Phe Ser Phe Pro Ser Gly

130 135 140

His Ala Leu Ala Ser Ala Leu Phe Tyr Gly Ser Leu Ala Leu Leu Leu 145 150 155 160

Cys Tyr Ser Asn Ala Asn Asn Arg He Lys Thr He Gly Ala He He

165 170 175

Leu Leu Phe Trp He Phe Leu Met Ala Tyr Asp Arg Val Tyr Leu Gly

180 185 190

Val His Tyr Pro Ser Asp Val Leu Gly Gly Phe Leu Leu Gly He Ala

195 200 205

Trp Ser Cys Cys Ser Leu Ala Leu Tyr Leu Gly Phe Leu Lys Arg Pro

210 215 220

Tyr Lys Ala Ala 225

(2) INFORMATION FOR SEQ ID NO: 909:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 157 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL : YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM_^: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...157

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 909 :

Met Lys Lys Phe Gly Leu Gly Val Tyr Leu Leu Leu Leu Gly He Leu

1 5 10 15

Gly Gly Ser Leu He He Leu Gly Ala He Val Ala Pro He Val Phe

20 25 30

Lys Ala Ser Ser He Leu Pro Glu Leu Asn Leu Thr Pro Phe Glu Ser

35 40 45

Gly Lys Leu Met Ala Gin He Phe Val Arg Phe Asn Tyr Val Leu Gly

50 55 60

Ala He Gly Phe Val Val Leu Leu Tyr Glu He He Ser Phe He Tyr 65 70 75 80

Tyr Lys Arg Ser Leu Val Tyr Leu He Leu Gly Val Ala He Gly Ala

85 90 95

Leu Cys Leu Leu Phe Val Phe Tyr Tyr Thr Pro Tyr He Leu Asn Ala

100 105 110

Gin Lys Val Gly Glu Val Ala Leu Gin Ser Ala Glu Phe Ala Arg Ser 115 120 125

His Ala Gin Ser Glu Trp Leu Phe Lys Glu Leu Phe Val Leu Val Cys

130 135 140

Ala Leu Phe Phe Trp Arg Leu Phe Gly Lys Asn Ala Leu 145 150 155

(2) INFORMATION FOR SEQ ID NO: 910:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 110 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 110

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 910 :

Leu He Asn Leu Leu Pro Hi s His Tyr His Lys Phe Pro Pro Asn He

1 5 10 15

Asn Pro Ser Leu He Ser Leu Lys Asp Arg Phe Leu Pro His Glu Lys

20 25 30

His Ser Gin Lys Val Lys Lys Glu Cys Val Asn Leu Phe Glu Val Leu

35 40 45

Ser Pro Leu His Lys He Asp Glu Lys Tyr Leu Phe His Leu Lys He

50 55 60

Ala Gly Glu Leu Ala Ser Met Gly Lys He Leu Ser Val Tyr Leu Ala 65 70 75 80

His Lys His Ser Ala Tyr Phe He Leu Asn Ala Leu Ser Tyr Gly Phe

85 90 95

Ser His Gin Asp Arg Ala He He Cys Leu Leu Gly Ala He 100 105 110

(2) INFORMATION FOR SEQ ID NO: 911:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 215 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature ( B ) LOCATION 1 . . . 215

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 911 :

Met Lys Ser Phe Leu Lys Leu Phe Ala Gin Pro Leu Leu Val Val Leu

1 5 10 15

Ala Phe Met Leu Leu Tyr Ala Leu Ala His Ala Val Leu Gly Phe Tyr

20 25 30

Val Lys Lys Asp Ser Ala Pro Met Ser Pro Asn Val Glu Lys Ser Glu

35 40 45

Thr Glu Arg Gin Asn Ser Thr Phe Ser Pro Lys Glu Glu Ala Asn Ala

50 55 60

Thr Thr Thr Ala Thr Glu Gin Asn Pro Thr Lys Asp Thr Val Pro Pro 65 70 75 80

Leu Asp Thr Ala Thr Gin Lys Gin Glu He Lys Gin Glu He Lys Gin

85 90 95

Glu He Lys Gin Glu He Lys Gin Glu He Lys Gin Glu He Lys Gin

100 105 110

Glu He Lys Gin Glu Thr Lys Gin Glu Gin Glu Lys Glu Asn Lys Pro

115 120 125

Lys Gin Asn Ser Val Ser Pro Val Gin Asn Asp Gin Lys Thr Pro Thr

130 135 140

Thr Pro Leu Met Gly Lys Lys Pro Leu Glu Tyr Lys Val Ala Val Ser 145 150 155 160

Gly Val Asn Val Arg Ala Phe Pro Ser Thr Lys Gly Lys He He Gly

165 170 175

Ser Leu He Lys Asn Lys Ser Val Lys Val Leu Glu He Gin Asn Asp

180 185 190

Trp Ala Glu He Glu Phe Ser His Glu Thr Lys Gly Tyr Val Phe Leu

195 200 205

Lys Leu Leu Lys Lys Ala Glu 210 215

(2) INFORMATION FOR SEQ ID NO: 912:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 79 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...79

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 912:

Met Trp Pro Val Ala Leu Lys Gin Pro Asn Arg Val Ser His His Phe 1 5 10 15

Tyr He Met Ala Met Leu Phe He Leu Phe Asp Val Glu He Val Phe 20 25 30 Met Phe Pro Trp Ala He Asp Phe Lys Lys Leu Gly Leu Phe Gly Leu

35 40 45

Val Glu Met Leu Gly Phe Val Phe Phe Leu Ala He Gly Phe He Tyr

50 55 60

Ala Leu Lys Arg Asn Ala Leu Ser Trp Gin Lys Leu Glu Val Lys 65 70 75

(2) INFORMATION FOR SEQ ID NO: 913:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 416 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...416

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 913 :

Met Cys Gly Met Phe Lys Asn Glu He Ser Ala He Gin Gly Met He

1 5 10 15

Ala Asn Ala Gin Glu Ala Val Ala Gin Ala Lys He Val Ser Glu Asn

20 25 30

Thr Gin Asn Gin Asn Ser Leu Asp Ala Gly Lys Pro Phe Asn Pro Tyr

35 40 45

Thr Asp Ala Ser Phe Ala Glu Ser Met Leu Lys Asn Ala Gin Ala Gin

50 55 60

Ala Glu He Leu Asn Gin Ala Glu Gin Val Val Lys Asn Phe Glu Lys 65 70 75 80

He Pro Thr Ala Phe Val Asn Asp Ser Leu Gly Val Cys Tyr Glu Val

85 90 95

Gin Gly Gly Glu Arg Arg Gly Thr Asn Pro Gly Gin Thr Thr Ser Asn

100 105 110

Thr Trp Gly Ala Gly Cys Ala Tyr Val Gly Gin Thr He Thr Asn Leu

115 120 125

Lys Asn Ser He Ala His Phe Gly Thr Gin Glu Gin Gin He Gin Gin

130 135 140

Ala Glu Asn He Ala Asp Thr Leu Val Asn Phe Lys Ser Arg Tyr Ser 145 150 155 160

Glu Leu Gly Asn Thr Tyr Asn Ser He Thr Thr Ala Leu Ser Asn He

165 170 175

Pro Asn Ala Gin Ser Leu Gin Asn Ala Val Ser Lys Lys Asn Asn Pro

180 185 190

Tyr Ser Pro Gin Gly He Asp Thr Asn Tyr Tyr Leu Asn Gin Asn Ser

195 200 205

Tyr Asn Gin He Gin Thr He Asn Gin Glu Leu Gly Arg Asn Pro Phe

210 215 220

Arg Lys Val Gly He Val Ser Ser Gin Thr Asn Asn Gly Ala Met Asn 225 230 235 240 Gly He Gly He Gin Val Gly Tyr Lys Gin Phe Phe Gly Gin Lys Arg

245 250 255

Lys Trp Gly Ala Arg Tyr Tyr Gly Phe Phe Asp Tyr Asn His Ala Phe

260 265 270

He Lys Ser Ser Phe Phe Asn Ser Ala Ser Asp Val Trp Thr Tyr Gly

275 280 285

Phe Gly Ala Asp Ala Leu Tyr Asn Phe He Asn Asp Lys Ala Thr Asn

290 295 300

Phe Leu Gly Lys Asn Asn Lys Leu Ser Val Gly Leu Phe Gly Gly He 305 310 315 320

Ala Leu Ala Gly Thr Ser Trp Leu Asn Ser Glu Tyr Val Asn Leu Ala

325 330 335

Thr Met Asn Asn Val Tyr Asn Ala Lys Met Asn Val Ala Asn Phe Gin

340 345 350

Phe Leu Phe Asn Met Gly Val Arg Met Asn Leu Ala Arg Pro Lys Lys

355 360 365

Lys Asp Ser Asp His Ala Ala Gin His Gly He Glu Leu Gly Leu Lys

370 375 380

He Pro Thr He Asn Thr Asn Tyr Tyr Ser Phe Met Gly Ala Glu Leu 385 390 395 400

Lys Tyr Arg Arg Leu Tyr Ser Val Tyr Leu Asn Tyr Val Phe Ala Tyr 405 410 415

(2) INFORMATION FOR SEQ ID NO: 914:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 114 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...114

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 914 :

Met Ala Thr He Gin Pro Phe Asn Hi s Ser Thr He Gin Pro Phe Asn

1 5 10 15

His Ser Thr He Gin Pro Phe Asn His Ser He He Gin Ser Phe Asn

20 25 30

His Ser Thr He Gin Ala Thr Leu Pro Tyr Phe Tyr Asn Tyr Leu Ser

35 40 45

Phe Tyr Lys Asn Leu Phe Lys Asn Pro Leu Phe Phe He He Pro Pro

50 55 60

Phe He Asn Pro Phe He Asn Pro Phe He Asn Pro Phe He Asn Pro 65 70 75 80

Phe He Asn Pro Phe He Asn Pro Phe He Asn Pro Phe He Asn Pro

85 90 95

Phe He Asn Pro Phe He Asn Pro Phe He Asn Pro Phe He Asn Pro 100 105 110 Phe He

(2) INFORMATION FOR SEQ ID NO: 915:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 126 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...126

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 915:

Leu Val Ser Glu Tyr Trp Leu Lys Phe Phe Thr Arg Ser Phe Ser Lys

1 5 10 15

Ser Thr Met Leu Phe Lys Thr Leu Leu Arg Ser Phe Phe Thr Phe Pro

20 25 30

Val Glu Leu Ser Glu Asn He Thr Leu Gly Ser Thr Val Val Leu He

35 40 45

Val Ala Glu Ala Val Ser Ala Leu Asn Lys Lys Val Val Ala Ala Lys

50 55 60

Lys Asn Lys He Arg Phe Thr Pro Asn Ser Tyr He His Asn Arg Asn 65 70 75 80

Lys Asn Arg Arg Tyr Ser Ser Leu Ser Pro Leu Leu Lys Ser Ser Ser

85 90 95

He Tyr Lys Asn Pro Pro Arg He Gin Ala He Leu He He Leu Lys

100 105 110

Tyr Arg Leu Ser Lys Gly He Tyr His Leu Gly Met He Leu 115 120 125

(2) INFORMATION FOR SEQ ID NO: 916:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 286 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...286 ( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 916 :

Met Lys Lys Ser Val H e Val Gly Ala He Ser Leu Ala Met Thr Ser

1 5 10 15

Leu Leu Ser Ala Glu Thr Pro Lys Gin Glu Lys Ala He Lys Thr Ser

20 25 30

Pro Thr Lys Lys Gly Glu Arg Asn Ala Ala Phe He Gly He Asp Tyr

35 40 45

Gin Leu Gly Met Leu Ser Thr Thr Ala Gin Asn Cys Ser His Gly Asn

50 55 60

Cys Asn Gly Asn Gin Ser Gly Ala Tyr Gly Ser Asn Thr Pro Asn Met 65 70 75 80

Pro Thr Ala Ser Asn Pro Thr Gly Gly Leu Thr His Gly Ala Leu Gly

85 90 95

Thr Arg Gly Tyr Lys Gly Leu Ser Asn Gin Gin Tyr Ala He Asn Gly

100 105 110

Phe Gly Phe Val Val Gly Tyr Lys His Phe Phe Lys Lys Ala Pro Gin

115 120 125

Phe Gly Met Arg Tyr Tyr Gly Phe Phe Asp Phe Ala Ser Ser Tyr Tyr

130 135 140

Lys Tyr Tyr Thr Tyr Asn Asp Tyr Gly Met Arg Asp Ala Arg Lys Gly 145 150 155 160

Ser Gin Ser Phe Met Phe Gly Tyr Gly Ala Gly Thr Asp Val Leu Phe

165 170 175

Asn Pro Ala He Phe Asn Arg Glu Asn Leu His Leu Gly Phe Phe Leu

180 185 190

Gly Val Ala He Gly Gly Thr Ser Trp Gly Pro Thr Asn Tyr Tyr Phe

195 200 205

Lys Asp Leu Ala Glu Glu Tyr Arg Gly Ser Phe His Pro Ser Asn Phe

210 215 220

Gin Val Leu Val Asn Gly Gly He Arg Leu Gly Thr Lys His Gin Gly 225 230 235 240

Phe Glu He Gly Leu Lys He Gin Thr He Arg Asn Asn Tyr Tyr Thr

245 250 255

Ala Ser Ala Asp Asn Val Pro Glu Gly Thr Thr Tyr Arg Phe Thr Phe

260 265 270

His Arg Pro Tyr Ala Phe Tyr Trp Arg Tyr He Val Ser Phe 275 280 285

(2) INFORMATION FOR SEQ ID NO: 917:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 285 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...285 ( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 917 :

Val Lys Arg He Leu Phe Phe Leu Ala Ala Thr Thr Phe Leu Leu Arg

1 5 10 15

Ala Glu Thr Ala Ser Ala Thr He Asn Thr Thr Val Asp Pro Asn Val

20 25 30

Met Phe Ser Glu Ser Ser Thr Gly Asn Val Lys Lys Asp Arg Lys Arg

35 40 45

Val Leu Lys Ser Met Val Asp Leu Glu Lys Glu Arg Val Lys Asn Phe

50 55 60

Asn Gin Tyr Ser Glu Thr Lys Met Ser Lys Gly Asp Leu Ser Ala Phe 65 70 75 80

Gly Ala Phe Phe Lys Gly Ser Leu Glu Asp Cys Val Glu Gin Lys He

85 90 95

Cys Tyr Tyr Glu His Arg Asn Gly Lys Val Ser Phe Val Val Asn Asp

100 105 110

Arg Glu Lys Phe Tyr Lys His Val Leu Lys Asp Leu Gly Thr Glu Leu

115 120 125

Ser Leu Pro Leu Phe Asn Trp Leu Tyr Lys Gly Ser Asp Phe Gly Ala

130 135 140

Leu His Glu Gin Phe Gly Asp Met Tyr Asp Gly Tyr He Lys Tyr Leu 145 150 155 160

He Ser Met Val Arg Val Ser Gin Lys Glu Lys Ala Arg Lys Val Asp

165 170 175

Ala He Val Leu Lys Lys Met Glu Glu Gin Ala Glu Lys Asp Thr Lys

180 185 190

Ala Ala Phe Gin Lys Arg Ser Ser Gly Glu Leu Glu Ser His Thr Asp

195 200 205

Ser Pro Glu Phe He Ser Ser Ser Lys Thr Gin Asn Ser Ser Asn Pro

210 215 220

Asp Leu Asp Pro Met Thr Asn Ala Asn Thr Leu Lys Glu Thr Ala Ser 225 230 235 240

Lys Glu Pro Glu Thr Ser Ser Lys Lys Glu Lys Lys Pro Lys Lys Lys

245 250 255

Arg Arg Leu Ser Lys Lys Glu Lys Gin Gin Gin Ala Leu Gin Gin Glu

260 265 270

Phe Glu Lys Gin He Ser Asp Ser Ser Lys Ser Glu Lys 275 280 285

(2) INFORMATION FOR SEQ ID NO: 918:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 75 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...75 (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 918:

Met Pro Lys Glu Asn Thr Thr His Glu Asp Ala Leu Ala Lys Cys Phe

1 5 10 15

Ala Pro Ala He Phe Lys Ala He Met Leu Asn Lys Leu He Leu Ala

20 25 30

Val Val Ala Ala Pro He He Lys Met Leu Lys Leu Ser Lys Glu He

35 40 45

Trp Trp Lys Lys Met Gly Lys Lys His Ala He Asp Phe Lys Met Arg

50 55 60

He Lys He Leu Ala Ser Leu Ala Pro Ser Phe 65 70 75

(2) INFORMATION FOR SEQ ID NO: 919:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 134 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...134

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 919 :

Met Cys Gin He Gin Cys Leu Leu He Leu Leu Ser He Asn He Val

1 5 10 15

Ser Ala He He Val Tyr Phe Phe Gin Ala Phe Gin Gly Val Leu Asn

20 25 30

Phe Glu Gly Gly Phe Leu Gly Phe Phe He Val Ala Leu Ser Ser Tyr

35 40 45

Tyr Gly Val Lys Lys Arg Leu Asp Leu Arg Lys Gin Asp Ser Lys Glu

50 . 55 60

Lys Glu Glu Lys Gin Lys Phe Gin Lys Phe Ala Leu Gly Leu Glu Met 65 70 75 80

Ser Phe Asn Val Trp Arg Leu Gly Gly Tyr Gly Val Leu Leu Gly He

85 90 95

Leu Gly Val Leu Leu Phe Leu His Leu Phe Asn Gly Leu Pro Phe Leu

100 105 110

He Gly Val Phe Val Ser Ser Leu Ser Ser Ala Leu Leu Arg Phe Leu

115 120 125

Asn Asn Asn Gly Lys Phe 130

(2) INFORMATION FOR SEQ ID NO: 920:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 92 amino acids (B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...92

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 920 :

Met Ala Cys Glu Phe Leu Lys Lys Pro Lys Tyr Tyr Lys Phe He Glu

1 5 10 15

Gly Ala Asn Tyr Leu Ser Leu Gly Leu Ser Met Val Val Ala He Leu

20 25 30

Met Gly Val Ala He Gly Tyr Gly Leu Lys Lys Leu Thr His He Ser

35 40 45

Trp Leu Phe Trp Leu Gly Val He Trp Gly Val Leu Ala Ser Phe Leu

50 55 60

Asn Val Tyr Lys Ala Tyr Lys Asn Met Gin Lys Asp Tyr Glu Glu Leu 65 70 75 80

Ala Lys Asp Pro Lys Tyr Thr Gin Asn Lys Thr Lys 85 90

(2) INFORMATION FOR SEQ ID NO: 921:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 80 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...80

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 921 :

Met Glu Asp Phe Leu Tyr Asn Thr Leu Tyr Phe He Glu Asp Tyr Lys

1 5 10 15

Leu Val Val He Phe Ser Phe He Gly Leu He Ala Leu Phe Phe Leu

20 25 30

Tyr Lys Phe He Lys Thr Gin Lys Lys Val Phe Lys Asp Lys Ala Asn

35 40 45

Gin Pro Gin Lys Lys Lys Ser Phe Lys Glu He He He Asp Gly Leu 50 55 60 Lys Glu Arg Val Lys Thr Phe Gly Phe Arg Leu Gin Ala He Leu Leu 65 70 75 80

(2) INFORMATION FOR SEQ ID NO: 922:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 363 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A ) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 363

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 922 :

Met Ala He Asp Leu Ala Glu Val Thr Gly Ala Lys Ala Ala Gin Glu

1 5 10 15

Arg Lys Lys Glu Gin Pro Thr He Ala Asn Gly Leu Asp Lys Asn Ala

20 25 30

Phe Met Lys Leu Phe Leu Glu Gin Leu Lys Asn Gin Asp Pro Thr Ala

35 40 45

Pro Met Glu Thr Asp Lys He He Thr Gin Thr Ala Gin Leu Thr Gin

50 55 60

Val Glu Met Gin Glu Glu Asn Lys Lys Thr Met Gin Glu Val Ala Ser 65 70 75 80

Ala Met Lys Ser Asn Lys Glu Thr Asn Glu Ser Leu Lys Asp Phe Gin

85 90 95

Gly Ala Leu Lys Asp Thr Met Glu Asn Leu Asn Lys Gly Met Asp Asp

100 105 110

Ser Leu Lys Ala Asn Asn Ala Leu Arg Glu Val Ser Ala Leu Asn Ser

115 120 125

Val Ser Met He Gly Lys He Ala Glu Thr Asp Val Ser Gly Ala Asn

130 135 140

Phe Asp Gly Asn Asn Lys Leu Ser Phe Ser Leu Phe Phe Asp Glu Lys 145 150 155 160

He Asp Ala Ser Lys Gly Val Pro Ala He Gin He Leu Asn Glu Asn

165 170 175

Asn Glu Leu Val Lys Thr He Pro Leu Lys Asp Tyr Asn Gly Gin Lys

180 185 190

Gly Tyr He Asn Phe Glu Trp Asp Gly Thr Asn Glu Lys Gly Glu Lys

195 200 205

Val Pro Lys Gly Asn Tyr Lys He Lys Ala Glu Tyr Asn Leu Asp Ser

210 215 220

Gin Ser Lys Gin Tyr Leu Gin Thr Arg He Gly Arg Gly Glu Val Glu 225 230 235 240

Ser Val He Phe Asp Lys Gly Lys Pro Met Leu Arg Met Gly Glu Met

245 250 255

He Leu Pro He Asp Ser Ala He Glu Phe Tyr Lys Pro Asp Gin Lys 260 265 270 Pro Leu Asp Gin Lys Leu Ser Asp Gin Lys Pro Gin Lys Leu Ser Glu

275 280 285

Gin Lys Ala Leu Glu Gin Lys He Ser Glu Gin Lys Pro Gin Glu Pro

290 295 300

Leu Asp Gin Lys Leu Ser Asp Gin Lys Pro Gin Lys Pro Leu Glu Gin 305 310 315 320

Lys He Ser Glu Gin Lys Pro Leu Asp Gin Lys Leu Ser Asp Gin Lys

325 330 335

Pro Gin Lys Pro Leu Glu Gin Lys He Ser Glu Gin Lys Pro Leu Asp

340 345 350

Gin Lys Pro Gin Thr Pro Pro Lys Glu Thr Ala 355 360

(2) INFORMATION FOR SEQ ID NO: 923:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 217 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...217

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 923 :

Leu Lys His Leu Ala Pro Leu He His He Pro Phe Lys Ala Leu Trp

1 5 10 15

Leu Gly Thr Ala Leu Ser Met Phe Leu Ser Leu Asn Leu Asn Ala Glu

20 25 30

Glu Asn Pro Thr Lys Thr Glu Pro Lys Pro Ala Lys Gly Val Lys Asn

35 40 45

Lys Pro Lys Ser Pro Val Thr Asn Val Met Met Thr Asn Cys Asp Asn

50 55 60

Leu Lys Asp Phe Asn Ala Lys Gin Lys Glu Val Leu Lys Ala Ala Tyr 65 70 75 80

Gin Phe Gly Ser Lys Glu Asn Leu Gly Tyr Glu Met Ala Gly He Ala

85 90 95

Trp Lys Glu Ser Cys Ala Gly Thr Tyr Lys He Asn Phe Ser Asn Pro

100 105 110

Ser Ala Gly He Tyr His Ala Tyr He Pro Ser Val Leu Lys Ser Tyr

115 120 125

Gly His Asn Asn Ser Pro Phe Leu Arg Asn Val Met Gly Glu Leu Leu

130 135 140

He Lys Asp Asp Ala Phe Ala Ser Glu Val Ala Leu Lys Glu Leu Leu 145 150 155 160

Tyr Trp Lys Thr Arg Tyr His Asp Asn Leu Lys Asp Met He Lys Ser

165 170 175

Tyr Asn Lys Gly Ser Arg Trp Glu Lys Asn Glu Lys Ala Asn Ala Asp 180 185 190 Ala Glu Lys Tyr Tyr Glu Glu He Gin Asp Arg He Arg Arg Leu Lys

195 200 205

Glu Ser Lys He Phe Glu Leu Ala Val 210 215

(2) INFORMATION FOR SEQ ID NO: 924.

(l) SEQUENCE CHARACTERISTICS-

(A) LENGTH. 366 ammo acids

(D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...366

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 924:

Met Gin Phe Gin Lys Thr Leu Leu Ser Leu Ser Leu Leu Phe Leu Ser

1 5 10 15

Tyr Cys He Ala Glu Glu Asn Gly Ala Tyr Ala Ser Val Gly Phe Glu

20 25 30

Tyr Ser He Ser His Ala Val Glu His Asn Asn Pro Phe Leu Asn Gin

35 40 45

Glu Arg He Gin Thr He Ser Asn Ala Gin Asn Lys He Tyr Lys Leu

50 55 60

Asn Gin Val Lys Asn Glu He Thr Asn Met Pro Asn Thr Phe Asn Tyr 65 70 75 80

He Asn Asn Ala Leu Lys Asn Asn Ala Lys Leu Thr Pro Thr Glu Lys

85 90 95

Gin Ala Glu Thr Tyr Tyr Leu Gin Ser Thr Leu Gin Asn He Glu Lys

100 105 110

He Val Met Leu Ser Gly Gly Val Ala Ser Asn Pro Lys Leu Ala Gin

115 120 125

Ala Leu Glu Lys Met Gin Glu Pro He Thr Asn Pro Leu Glu Leu Val

130 135 140

Glu Asn Leu Lys Asn Leu Glu Leu Gin Phe Ser Gin Ser Gin Asn Ser 145 150 155 160

Met Leu Ser Ser Leu Ser Ser Gin He Ala Gin He Ser Asn Ser Leu

165 170 175

Asn Ala Leu Asp Pro Ser Ser Tyr Ser Lys Asn Val Ser Ser Met Tyr

180 185 190

Gly Val Gly Leu Ser Val Gly Tyr Lys His Phe Phe Thr Lys Lys Lys

195 200 205

Asn Gin Gly Phe Arg Tyr Tyr Leu Phe Tyr Asp Tyr Gly Tyr Thr Asn

210 215 220

Phe Gly Phe Val Gly Asn Gly Phe Asp Gly Leu Gly Lys Met Asn Asn 225 230 235 240

His Leu Tyr Gly Leu Gly He Asp Tyr Leu Phe Asn Phe He Asp Asn 245 250 255 Ala Gin Lys His Ser Ser Val Gly Phe Tyr Val Gly Phe Ala Leu Ala

260 265 270

Gly Ser Ser Trp Val Gly Ser Gly Leu Gly Met Trp Val Ser Gin Met

275 280 285

Asp Phe He Asn Asn Tyr Leu Thr Asp Tyr Arg Ala Lys Met His Thr

290 295 300

Ser Phe Phe Gin He Pro Leu Asn Phe Gly Val Arg Val Asn Val Asp 305 310 315 320

Arg His Asn Gly Phe Glu Met Gly Leu Lys He Pro Leu Ala Val Asn

325 330 335

Ser Phe Tyr Glu Thr His Gly Lys Gly Leu Asn Ala Ser Leu Phe Phe

340 345 350

Lys Arg Leu Val Met Phe Asn Val Ser Tyr Val Tyr Ser Phe 355 360 365

(2) INFORMATION FOR SEQ ID NO: 925:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 366 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...366

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 925:

Met Gin Phe Gin Lys Thr Leu Leu Ser Leu Ser Leu Leu Phe Leu Ser

1 5 10 15

Tyr Cys He Ala Glu Glu Asn Gly Ala Tyr Ala Ser Val Gly Phe Glu

20 25 30

Tyr Ser He Ser His Ala Val Glu His Asn Asn Pro Phe Leu Asn Gin

35 40 45

Glu Arg He Gin Thr He Ser Asn Ala Gin Asn Lys He Tyr Lys Leu

50 55 60

Asn Gin Val Lys Asn Glu He Thr Asn Met Pro Asn Thr Phe Asn Tyr 65 70 75 80

He Asn Asn Ala Leu Lys Asn Asn Ala Lys Leu Thr Pro Thr Glu Lys

85 90 95

Gin Ala Glu Thr Tyr Tyr Leu Gin Ser Thr Leu Gin Asn He Glu Lys

100 105 110

He Val Met Leu Ser Gly Gly Val Ala Ser Asn Pro Lys Leu Ala Gin

115 120 125

Ala Leu Glu Lys Met Gin Glu Pro He Thr Asn Pro Leu Glu Leu Val

130 135 140

Glu Asn Leu Lys Asn Leu Glu Leu Gin Phe Ser Gin Ser Gin Asn Ser 145 150 155 160

Met Leu Ser Ser Leu Ser Ser Gin He Ala Gin He Ser Asn Ser Leu 165 170 175 Asn Ala Leu Asp Pro Ser Ser Tyr Ser Lys Asn Val Ser Ser Met Tyr

180 185 190

Gly Val Gly Leu Ser Val Gly Tyr Lys His Phe Phe Thr Lys Lys Lys

195 200 205

Asn Gin Gly Phe Arg Tyr Tyr Leu Phe Tyr Asp Tyr Gly Tyr Thr Asn

210 215 220

Phe Gly Phe Val Gly Asn Gly Phe Asp Gly Leu Gly Lys Met Asn Asn 225 230 235 240

His Leu Tyr Gly Leu Gly He Asp Tyr Leu Phe Asn Phe He Asp Asn

245 250 255

Ala Gin Lys His Ser Ser Val Gly Phe Tyr Val Gly Phe Ala Leu Ala

260 265 270

Gly Ser Ser Trp Val Gly Ser Gly Leu Gly Met Trp Val Ser Gin Met

275 280 285

Asp Phe He Asn Asn Tyr Leu Thr Asp Tyr Arg Ala Lys Met His Thr

290 295 300

Ser Phe Phe Gin He Pro Leu Asn Phe Gly Val Arg Val Asn Val Asp 305 310 315 320

Arg His Asn Gly Phe Glu Met Gly Leu Lys He Pro Leu Ala Val Asn

325 330 335

Ser Phe Tyr Glu Thr His Gly Lys Gly Leu Asn Ala Ser Leu Phe Phe

340 345 350

Lys Arg Leu Val Met Phe Asn Val Ser Tyr Val Tyr Ser Phe 355 360 365

(2) INFORMATION FOR SEQ ID NO: 926:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 174 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...174

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 926:

Leu Asn Thr Met Asn Ser Val Leu Glu Cys Lys Glu Leu Ala Leu Tyr

1 5 10 15

Gly Gly Ser Phe Asp Pro Leu His Lys Ala His Leu Ala He He Glu

20 25 30

Gin Thr Leu Glu Leu Leu Pro Phe Val Gin Leu He Val Leu Pro Ala

35 40 45

Tyr Gin Asn Pro Phe Lys Lys Pro Cys Phe Leu Asp Ala Lys Thr Arg

50 55 60

Phe Lys Glu Leu Glu Arg Ala Leu Lys Gly Met Pro Arg Val Leu Leu 65 70 75 80

Ser Asp Phe Glu He Lys Gin Glu Arg Ala Val Pro Thr He Glu Ser 85 90 95 Val Leu His Phe Gin Lys Leu Tyr Arg Pro Lys Thr Leu Tyr Leu Val

100 105 110

He Gly Ala Asp Cys Leu Arg His Leu Ser Ser Trp Thr Asn Ala Lys

115 120 125

Glu Leu Leu Lys Arg Val Glu Leu Val Val Phe Glu Arg He Gly Tyr

130 135 140

Glu Glu He Gin Phe Lys Gly Arg Tyr His Pro Leu Lys Gly He Asp 145 150 155 160

Ala Pro He Ser Ser Ser Ala He Arg Ala Ser Leu Gly Val 165 170

(2) INFORMATION FOR SEQ ID NO: 927:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 376 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...376

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 927:

Met Arg Phe Phe Cys Phe Phe Leu Phe Phe Leu Thr Phe Ser Asn Ala

1 5 10 15

Gin He Met Met Thr Phe Asp Ser Gin Thr Asn Ala Lys Leu Ser Arg

20 25 30

Ser Asn Glu Gin Leu Ser Asp Met Leu Tyr Lys Leu Asn Glu Ser Leu

35 40 45

Arg He Tyr Gin Asn Val Leu Ser Asn Asn Gin Asp Gin Leu Lys Glu

50 55 60

He Lys Lys Ala Asn Ser Thr Leu Thr Ser Gin Arg Arg Phe Phe Asn 65 70 75 80

Ala Ser Gin He Arg Leu Met Asp Thr Asp Ala Leu Leu Lys Gin Ser

85 90 95

Ala Leu Glu Leu Glu Lys Leu Gin Ala Leu Glu Lys His Leu Lys Glu

100 105 110

Ser Met Glu His Glu Arg Leu He Lys Glu Ser Gin Ala Leu Phe Leu

115 120 125

Gin Glu His Cys Pro Tyr Leu Ser Gly Val Lys Asn Leu Glu Glu Ala

130 135 140

Ser Asn Ala Leu Glu Val Gin Glu Lys Asn Asn Ala Leu Phe Leu Leu 145 150 155 160

Lys Glu Pro Lys Leu Phe His Leu Leu Ser Arg Leu Asp Leu Met Ser

165 170 175

Ala Leu Asn Ala Leu Cys Asp Gin Val Leu Glu Asn Glu He Gin Asp

180 185 190

Gin Gin Ser His Asn Lys Thr Leu Glu Tyr Asn Ala Leu Met Asn His 195 200 205 Asp Phe Gin Ala Tyr Lys Ala Met Arg Leu Lys Lys He Lys Asn Lys

210 215 220

Leu Gin Ser Gin He Gin Ala Lys Glu Asp Ala Leu Lys Thr Phe Leu 225 230 235 240

Pro Leu Glu Lys Arg Leu Glu Thr Leu Lys Ser Arg Phe Leu Cys Asp

245 250 255

Lys Glu Asn Leu Lys Ser Cys Ala Asn Gin Leu Gin Gin Arg Tyr Gin

260 265 270

Asn Ala Leu He Glu Arg Asp Lys Glu Leu Lys Asn Ala Lys Asn Asn

275 280 285

Lys Glu Lys His Ala Leu He Leu Ala Asn Tyr Glu His Thr Leu Lys

290 295 300

Thr Leu Asn He Glu Phe Leu Ser Glu Leu Ser Glu Gin Met Ala Phe 305 310 315 320

Leu Asn Glu Thr Met Ala Leu Asn Ala Gin Val Leu Ala Leu Leu Ala

325 330 335

Gin Gin Gin Thr Lys Lys Pro Phe Asn Val Ser Asp Gly Leu Ser Gly

340 345 350

Gly Lys Ala Leu He Lys Asn He Arg Leu Asp Pro His Gly Phe Pro

355 360 365

Ser Phe Lys Asn Phe Lys Gin Glu 370 375

(2) INFORMATION FOR SEQ ID NO: 928:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 229 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...229

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 928 :

Val Lys Gly Glu Lys Asn Ala Trp Tyr Leu Gly He Ser Tyr Gin Val

1 5 10 15

Gly Gin Ala Ser Gin Ser Val Lys Asn Pro Pro Lys Ser Ser Glu Phe

20 25 30

Asn Tyr Pro Lys Phe Pro Val Gly Lys Thr Asp Tyr Leu Ala Val Met

35 40 45

Gin Gly Leu Gly Leu Thr Val Gly Tyr Lys Gin Phe Phe Gly Glu Lys

50 55 60

Arg Trp Phe Gly Ala Arg Tyr Tyr Gly Phe Met Asp Tyr Gly His Ala 65 70 75 80

Val Phe Gly Ala Asn Ala Leu Thr Ser Asp Asn Gly Gly Val Cys Lys

85 90 95

Leu Asn Glu Pro Cys Ala Thr Lys Val Gly Thr Met Gly Asn Leu Ser 100 105 110 Asp Met Phe Thr Tyr Gly Val Gly He Asp Thr Leu Tyr Asn Val He

115 120 125

Asn Lys Glu Asp Ala Ser Phe Gly Phe Phe Phe Gly Ala Gin He Ala

130 135 140

Gly Asn Ser Trp Gly Asn Thr Thr Gly Ala Phe Leu Glu Thr Lys Ser 145 150 155 160

Pro Tyr Lys His Thr Ser Tyr Ser Leu Asp Pro Ala He Phe Gin Phe

165 170 175

Leu Phe Asn Leu Gly He Arg Thr His He Gly Gin His Gin Glu Phe

180 185 190

Asp Phe Gly Val Lys He Pro Thr He Asn Val Tyr Tyr Phe Asn His

195 200 205

Gly Asn Leu Ser Phe Thr Tyr Arg Arg Gin Tyr Ser Leu Tyr Val Gly

210 215 220

Tyr Arg Tyr Asn Phe 225

(2) INFORMATION FOR SEQ ID NO: 929:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 479 ammo acids

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE.

(A) NAME/KEY: miscjeature

(B) LOCATION 1...479

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 929 :

Leu Lys Asn His Ser Phe Lys Lys Thr He Ala Leu Ser Leu Leu Ala

1 5 10 15

Ser Met Ser Leu Cys Asn Ala Glu Glu Asp Gly Ala Phe Phe Val He

20 25 30

Asp Tyr Gin Thr Ser Leu Ala Arg Gin Glu Leu Lys Asn Pro Gly Phe

35 40 45

Thr Gin Ala Gin Glu Leu Lys Gin Leu He Arg Asp Gly Ala Val Arg

50 55 60

Leu Gin Thr Ser Ala He Pro Leu Ser Tyr Tyr Leu Asp He Leu Gly 65 70 75 80

Asn Lys Thr Lys Thr Leu Leu Ser Glu Ser Leu Lys Asn Asn Pro Gin

85 90 95

Gin Pro Asn Gly Gin Pro Asn Gin Ala Leu Val Asn Leu Glu Gin Ser

100 105 110

Leu Gly He Leu Gly Lys Leu Leu Asp Leu Ser Gin Gin Tyr Ala Ser

115 120 125

Glu Gly Val He Lys Pro Leu Val Val Asp Val Gly Lys Glu Gin He

130 135 140

Gly He Thr Asp Ser Met Leu Leu Val Ala Gin Asn He Val Leu Ala 145 150 155 160 Leu Gly Gin Val Asp Leu Ser Lys He Gin Gin Asn Asn Gly Asn Gin

165 170 175

Gin Leu Tyr Glu Asn He Met Lys Val Met Leu Leu Gly Thr Gly Gly

180 185 190

Thr Asn Gly Ala Tyr Asn Gly Val Ser Val Gly Asp He Ala Thr Gly

195 200 205

Met Gin Asn Phe Pro Ser Gin Thr Gly Leu He Gly Ala Asn Ser Thr

210 215 220

Val Ser Glu Leu Asn Ala Leu He Lys Ser Gly He Ser Leu Asp Arg 225 230 235 240

Glu Thr Leu Gly Leu Gly Ser Phe He Glu Lys Asn He Cys Ser Gly

245 250 255

Ala Ser Ser Cys Phe Ser Gly Asn Gin Leu He Tyr Lys Lys Gly Leu

260 265 270

Asp Arg Thr He Asn He He Asn Ala Val Leu Gly Gin Phe Glu Ser

275 280 285

Ser Ala Ser Ser Leu Tyr Lys He Ser Tyr He Pro Asn Leu Phe Ser

290 295 300

Leu Lys Asp Tyr Gin Ser Ala Ser Met Asn Gly Phe Gly Ala Lys Met 305 310 315 320

Gly Tyr Lys Gin Phe Phe Thr His Lys Lys Asn He Gly Leu Arg Tyr

325 330 335

Tyr Gly Phe Leu Asp Tyr Gly Tyr Ala Asn Phe Gly Asp Thr Asn Leu

340 345 350

Lys Val Gly Ala Asn Leu Val Thr Tyr Gly Val Gly Thr Asp Phe Leu

355 360 365

Tyr Asn Val Tyr Glu Arg Ser Arg Arg Arg Glu Arg Thr Thr He Gly

370 375 380

Leu Phe Phe Gly Ala Gin He Ala Gly Gin Thr Trp Ser Thr Asn Val 385 390 395 400

Thr Asn Leu Leu Ser Gly Gin Arg Pro Asp Val Lys Ser Ser Ser Phe

405 410 415

Gin Phe Leu Phe Asp Leu Gly Val Arg Thr Asn Phe Ala Lys Thr Asn

420 425 430

Phe Asn Lys His Arg Leu Asp Gin Gly He Glu Phe Gly Val Lys He

435 440 445

Pro Val He Ala His Lys Tyr Phe Ala Thr Gin Gly Ser Ser Ala Ser

450 455 460

Tyr Met Arg Asn Phe Ser Phe Tyr Val Gly Tyr Ser Val Gly Phe 465 470 475

(2) INFORMATION FOR SEQ ID NO: 930:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 179 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature (B) LOCATION 1...179

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 930:

Met Ala Ser Leu Ala Phe Val Gin Ala Phe Leu Glu Ser Phe Lys Gly

1 5 10 15

Phe Leu Ser Gin Ala Thr Leu He Ser Val Leu He Ala Ser Val Leu

20 25 30

He Leu Phe Cys Ala He Leu Leu Leu Leu Ala Leu Leu Leu Arg Asn

35 40 45

Arg Trp Ala Ser Tyr He Thr Thr Ala Ala Phe Leu Gly Ala Phe Leu

50 55 60

Ser Met Pro Phe Val Leu Asn Val Leu Leu Thr Gin Ala He Tyr Pro 65 70 75 80

He Glu Thr Arg He Leu His Ala Asn Pro Leu Ser Tyr Ser Asn Ala

85 90 95

Phe Ser Leu Gin Val Gly Val Lys Asn He Ser Lys Phe Ser Leu Asn

100 105 110

Lys Cys Val Leu Arg Leu Glu Val Leu Lys Asn Pro His Asn Phe Val

115 120 125

Glu Glu Arg Ala Phe Lys Trp Phe Val Lys Lys Ser Tyr Glu Lys Thr

130 135 140

Phe Lys Glu Lys He Leu Pro Glu Glu Ser Lys Val Phe Ser Phe Phe 145 150 155 160

He Asp Asp Tyr Pro Tyr Ser Lys Thr Ala Pro Tyr Gin Val Ser Leu

165 170 175

Phe Cys Leu

(2) INFORMATION FOR SEQ ID NO: 931:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 129 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 129

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 931 :

Leu Gly Glu Leu Leu Gin Ala Ser Ala Pro Tyr Ala He Ala Pro Val

1 5 10 15

Glu Leu He Val Val Phe Tyr Lys Asn Glu Tyr Lys Arg Lys Lys Gin

20 25 30

Thr Ser Thr Met Ser Arg Glu Glu Phe Leu Leu Tyr Thr Asn Gly Leu

35 40 45

Trp Asn Phe Ser Gly Glu Ser Lys Lys Arg Leu Lys His Pro Ala Pro 50 55 60 Phe Pro Arg Glu Leu Pro Arg Arg Cys He Gin Leu Phe Ser Phe Leu 65 70 75 80

Glu Asp Thr He Phe Asp Pro Phe Ser Gly Ser Gly Thr Thr He Leu

85 90 95

Glu Ala Asn Ala Leu Gly Arg Phe Ser Val Gly Leu Glu He Glu Lys

100 105 110

Glu Tyr Cys Glu Leu Ser Lys Lys Arg He Leu Glu Ser Leu Ser Leu

115 120 125

Val

(2) INFORMATION FOR SEQ ID NO: 932:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 327 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...327

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:932:

Val Leu Lys Gly Leu Lys Lys Ala Phe Lys Glu Arg Phe Cys Ser Gin

1 5 10 15

Val Tyr He Ser Phe Asn Val Asp His Asn Leu Leu Ser Ala Gin Val

20 25 30

Leu Arg Val Lys Asn His Arg He Lys Glu Lys Phe Phe Lys Thr Phe

35 40 45

Glu Thr Lys Val Glu Thr Lys Asn Gly Glu Val Pro He Gin Ala Leu

50 55 60

Lys He Ala Arg Thr Tyr- Ser Gin Lys Tyr Pro Tyr Thr Tyr Phe Ser 65 70 75 80

Ala Met Ser Lys Ala Lys Glu Val Leu Cys Glu Lys Gin Ala Phe Glu

85 90 95

Gin He Lys Gin Glu Asn Gin Asp Tyr Gin Ala Cys Glu Val Asn Gin

100 105 110

Lys Tyr Cys Val Tyr Val Glu Ser Lys Asp Phe Leu Lys Asp Phe Lys

115 120 125

Arg Phe Lys He Gin Asp Val Asp Phe Leu Phe Ser Pro Phe Ser Leu

130 135 140

He Tyr Asp Phe Val Arg Asp Asn Leu Glu Asn Lys Pro Leu Leu Tyr 145 150 155 160

Leu Leu Leu Glu Arg Ser Arg Phe Tyr Phe Leu He Ala Asp Lys Lys

165 170 175

Glu He Phe Leu Ala Lys Ser Val Phe Leu Glu Glu Gin Pro Glu Glu

180 185 190

Phe He Glu Ser Lys Glu Glu Asp Ser Met Gly Met Asp Asn Glu Ala 195 200 205 Val Asp Leu Phe Leu Ser Glu He Gin Glu Asp He Asp Ser Leu Glu

210 215 220

Glu Ala He Gly Leu Asp Ser Ser Lys Asp Asn Ser Glu Lys He Thr 225 230 235 240

Glu Asp Ala Tyr Ser Leu He Glu Gly Met Thr Asn He Pro Leu He

245 250 255

Ala Asp Val Leu Gin Glu Gly Leu Arg Gly Val Tyr His Ser Arg Glu

260 265 270

He Asp Phe Val Glu Lys Val Val Val Leu Asp Ser Cys Gin He His

275 280 285

His Lys Ala Leu Met His Leu Gin Glu Thr Leu Met He Glu Val Asp

290 295 300

Arg Leu Asp Phe Ser Leu Val Glu Arg Leu Asn Val Leu Ala Arg Met 305 310 315 320

Glu Asn Glu Lys His Ala Phe 325

(2) INFORMATION FOR SEQ ID NO: 933:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 431 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A ) NAME / KEY : miscjeature

( B ) LOCATION 1 . . . 431

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 933 :

Met Asn He Gin Thr Lys Lys Arg Phe Leu Ala Asn Leu Leu Leu Phe

1 5 10 15

Ser Leu Phe Ser Cys Leu Lys Ala Glu Thr Leu Ser Glu Asp His Gin

20 25 30

He Leu Leu Ser Ser Asp Ala Phe His Arg Gly Asp Phe Ala Thr Ala

35 40 45

Gin Lys Gly Tyr Met Asn Leu Tyr Lys Gin Thr Asn Lys Val Val Tyr

50 55 60

Ala Lys Glu Ala Ala He Ser Ala Ala Ser Leu Gly Asp He Lys Thr 65 70 75 80

Ala Met His Leu Ala Met Leu Tyr Gin Lys He Thr Asn Asn Arg Asn

85 90 95

Asp Val Ser He Asn Lys He Leu Val Asp Gly Tyr Ala Gin Met Gly

100 105 110

Gin He Asp Lys Ala He Glu Leu Leu His Lys He Arg Lys Glu Glu

115 120 125

Lys Thr He Ala Thr Asp Asn Val Leu Gly Thr Leu Tyr Leu Thr Gin

130 135 140

Lys Arg Leu Asp Lys Ala Phe Pro Leu Leu Asn Lys Phe Tyr Asn Gln 145 150 155 160 Val His Asp Glu Asp Ser Leu Glu Lys Leu He Thr He Tyr Phe Leu

165 170 175

Gin Asn Arg Lys Lys Glu Gly Leu Asp Leu Leu Gin Ser His He Asp

180 185 190

Arg Tyr Gly Cys Ser Glu Gin Leu Cys Gin Lys Ala Leu Asn Thr Phe

195 200 205

Thr Gin Phe Asn Glu Leu Asp Leu Ala Lys Thr Thr Phe Ala Arg Leu

210 215 220

Tyr Glu Lys Asn Pro He Val Gin Asn Ala Gin Phe Tyr He Gly Val 225 230 235 240

Leu He Leu Leu Lys Glu Phe Asp Lys Ala Gin Gin He Ala Glu Leu

245 250 255

Phe Pro Phe Asp Arg Arg Leu Leu Leu Asp Leu Tyr Thr Ala Gin Lys

260 265 270

Lys Phe Asp Gin Ala Ser Lys Gin Ala Ser Leu He Tyr Gin Glu Arg

275 280 285

Lys Asp Pro Lys Phe Leu Gly Leu Glu Ala He Tyr His Tyr Glu Ser

290 295 300

Leu Ser Ala Asn Lys Lys Lys Leu Thr Lys Glu Glu Met Leu Pro He 305 310 315 320

He Gin Lys Leu Glu Gin Ala Thr Lys Glu Arg Gin Ala Trp Leu Ala

325 330 335

Lys Thr Lys Asp Lys Glu Asp Ala Gin Asp Ala Phe Phe Tyr Asn Phe

340 345 350

Leu Gly Tyr Ser Leu He Asp Tyr Asp Met Asp Val Lys Arg Gly Met

355 360 365

Asp Leu Val Arg Lys Ala Leu Ala Leu Asp Ser Asn Ser Val Leu Tyr

370 375 380

Leu Asp Ser Leu Ala Trp Gly Tyr Tyr Lys Leu Gly Asn Cys Leu Glu 385 390 395 400

Ala Lys Lys He Phe Ser Ser He Ala Lys Glu Leu He Gin Asn Glu

405 410 415

Pro Glu Leu Lys Glu His Asn Lys He He Gin Glu Cys Lys Lys 420 425 430

(2) INFORMATION FOR SEQ ID NO: 934:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 414 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...414

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 934:

Leu He Gin Lys Asn Lys Ser Leu Ser He Phe Leu He Ser Asn Ser 1 5 10 15 Val Val Phe Leu Gly Lys He He Leu His Lys Val Phe He Met Glu

20 25 30

Ala Leu Glu Cys Leu Lys Arg He Glu Lys Glu Ser He Gin Thr He

35 40 45

Tyr He Asp Pro Pro Tyr Asn Thr Lys Ser Ser Asn Phe Glu Tyr Glu

50 55 60

Asp Ala His Ala Asp Tyr Glu Lys Trp He Glu Glu His Leu He Leu 65 70 75 80

Ala Lys Ala Val Leu Lys Gin Ser Gly Cys He Phe He Ser Met Asp

85 90 95

Asp Asn Lys Met Ala Glu Val Lys He He Ala Asn Glu He Phe Gly

100 105 110

Thr Arg Asn Phe Leu Gly Thr Phe He Thr Lys Gin Ala Thr Arg Ser

115 120 125

Asn Ala Lys His He Asn He Thr His Glu Tyr Val Leu Ser Tyr Ala

130 135 140

Lys Asn Lys Ala Phe Ala Pro Gly Phe Lys He Leu Arg Thr Leu Leu 145 150 155 160

Pro He Tyr Ala Lys Ala Leu Lys Asp Leu Met Arg Thr He Lys Asn

165 170 175

Val Phe Lys Gin Lys Gly Gin Ala Gin Ala Gin Leu He Leu Lys Glu

180 185 190

Gin He Lys Glu Leu Ser Gin Lys Glu His Phe Asn Phe Leu Lys Asn

195 200 205

Tyr Asn Leu Val Asp Glu Lys Gly Glu He Tyr Phe Ala Lys Asp Leu

210 215 220

Ser Thr Pro Ser Asn Pro Arg Ser Val Ala He Gin Glu He Asn Leu 225 230 235 240

Phe Leu Glu Pro Leu Lys Ser Arg Gly Trp Ser Ser Asp Glu Lys Leu

245 250 255

Lys Glu Leu Tyr Tyr Gin Asn Arg Leu He Phe Lys Asn Asn Arg Pro

260 265 270

Tyr Glu Lys Tyr Tyr Leu Lys Glu Ser Gin Asp Asn Cys Leu Ser Val

275 280 285

Leu Asp Phe Tyr Ser Arg Gin Gly Thr Lys Asp Leu Glu Lys Leu Gly

290 295 300

Leu Lys Gly Leu Phe Lys Thr Pro Lys Pro Val Ala Leu He Lys Tyr 305 310 315 320

Leu Leu Leu Cys Ser Thr Pro Lys Asp Ser He He Leu Asp Phe Phe

325 330 335

Ala Gly Ser Gly Thr Thr Ala Gin Ala Val He Glu Val Asn Lys Asp

340 345 350

Tyr Tyr Leu Asn Trp Ser Phe Tyr Leu Cys Gin Lys Glu Glu Lys He

355 360 365

Lys Asn Asn Pro Gin Ala Val Ser He Leu Lys Asn Lys Gly Tyr Lys

370 375 380

Asn Thr He Ser Asp He Met Leu Leu Arg Leu Glu Lys He He Lys 385 390 395 400

Arg Ser Glu Tyr Glu He Leu Lys Thr Lys Ser He Leu Phe 405 410

(2) INFORMATION FOR SEQ ID NO: 935:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 166 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear (11) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...166

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 935 :

Leu Glu He Asp Lys Thr Glu Cys Ser Thr Leu Leu Ala Ser He Gin

1 5 10 15

Lys Gin Gin Leu Val He Pro Val Val Gly Asn Phe Ser Ala Gly Lys

20 25 30

Ser Thr Leu Leu Asn Arg Phe Leu Gly Ser Ser Val Leu Pro Thr Gly

35 40 45

He Thr Pro Glu Thr Ser Leu Ala Thr Glu Leu His Tyr Ser Ala Asn

50 55 60

Glu Arg He Glu Ala Phe Ser Ser Asn Asp Glu Lys Thr Glu Ser Phe 65 70 75 80

Glu Leu Asn Glu Gin Ser Phe Glu Ala He Lys Glu Asn Ala Ala Lys

85 90 95

Tyr Ser Tyr Leu Lys Val Tyr Leu Asn Asn Glu Ala Leu Lys Asp Ser

100 105 110

Ala Pro Leu Val Phe Val Asp Met Pro Gly Phe Asp Ser Pro He Ser

115 120 125

Ser His Thr His Ala He Leu Glu Tyr Leu Glu Arg Gly Val His Phe

130 135 140

Val He Leu Thr Ser Val Glu Glu Gly Asn Leu Thr Lys Arg Met Val 145 150 155 160

Arg Glu Leu Lys Thr Phe 165

(2) INFORMATION FOR SEQ ID NO: 936:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 251 ammo acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...251

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 936: Met Lys Leu Pro Val Val Glu Ser Phe Phe Ser Leu Gin Gly Glu Gly

1 5 10 15

Lys Arg He Gly Lys Pro Ser Leu Phe Leu Arg Leu Gly Gly Cys Asn

20 25 30

Leu Ser Cys Lys Gly Phe Asn Cys Lys Thr Leu Phe Asn Asp Glu He

35 40 45

Leu Thr Gly Cys Asp Ser Leu Tyr Ala Val His Pro Lys Phe Lys Thr

50 55 60

Ser Trp Asp Tyr Tyr Asn Glu Pro Lys Pro Leu He Glu Arg Leu Val 65 70 75 80

Asn Leu Ala Pro Asn Tyr Lys Asp Phe Asp Phe He Leu Thr Gly Gly

85 90 95

Glu Pro Ser Leu Tyr Phe Asn Asn Pro He Leu Leu Ser Val Leu Glu

100 105 110

His Phe Tyr His Lys Lys He Pro Leu Phe Val Glu Ser Asn Gly Ser

115 120 125

He Phe Phe Glu Phe Ser Pro He Leu Lys Glu Leu His Phe Thr Leu

130 135 140

Ser Val Lys Leu Ser Phe Ser Leu Glu Gin Glu Ser Lys Arg He Asn 145 150 155 160

Leu Lys Ala Leu Gin Asn He Leu Asn Asn Ala Lys Ser Val His Phe

165 170 175

Lys Phe Val Leu Glu Ser Gin Asn Ala Ala His Ser He Ala Glu He

180 185 190

Gin Ser Leu Leu Lys Gin Leu Ser Leu Lys Asn Asn Glu He Phe Leu

195 200 205

Met Pro Leu Gly Thr Thr Asn Asn Glu Leu Asp Lys Asn Leu Lys Thr

210 215 220

Leu Ala Pro Leu Ala He Glu His Gly Phe Arg Leu Ser Asp Arg Leu 225 230 235 240

His He Arg Leu Trp Asp Asn Lys Lys Gly Phe 245 250

(2) INFORMATION FOR SEQ ID NO: 937:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 381 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...381

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 937:

Met Asn Leu Asn Phe Met Pro Leu Leu His Ala Tyr Asn His Val Ser 1 5 10 15

He Asp Phe His Phe Asn Ser Ser Ala Arg Asp Phe Cys Val His Glu 20 25 30 Val Pro Leu Tyr Glu Phe Ser Asn Thr Gly Glu His Ala Val He Gin

35 40 45

Val Arg Lys Ser Gly Leu Ser Thr Leu Glu Met Leu Gin He Phe Ser

50 55 60

Gin He Leu Gly Val Lys He Ala Glu Leu Gly Tyr Ala Gly Leu Lys 65 70 75 80

Asp Lys Asn Ala Leu Thr Thr Gin Phe He Ser Leu Pro Lys Lys Tyr

85 90 95

Ala Pro Leu Leu Glu Lys Asn Thr Ser Asn Phe Gin Glu Arg Asn Leu

100 105 110

Lys He Leu Ser Leu Asn Tyr His His Asn Lys He Lys Leu Gly His

115 120 125

Leu Lys Gly Asn Arg Phe Phe Met Arg Phe Lys Lys Met Thr Pro Leu

130 135 140

Asn Ala Gin Lys Thr Glu Gin Val Leu Glu Gin He Ala Gin Phe Gly 145 150 155 160

Met Pro Asn Tyr Phe Gly Ser Gin Arg Phe Gly Lys Phe Asn Asp Asn

165 170 175

His Lys Glu Gly Leu Lys He Leu Gin Asn Glu Thr Lys Phe Ala His

180 185 190

Gin Lys Leu Asn Ala Phe Leu He Ser Ser Tyr Gin Ser Tyr Leu Phe

195 200 205

Asn Ser Leu Leu Ser Lys Arg Leu Glu He Ser Lys He He Ser Ala

210 215 220

Phe Ser Val Lys Glu Ser Leu Glu Phe Phe Lys Gin Lys Asn Leu Ser 225 230 235 240

Val His Ser Asn Ala Leu Lys Ala Leu Lys Asn Gin Ala His Pro Phe

245 250 255

Lys He Leu Glu Gly Asp Val Met Arg His Tyr Pro Tyr Gly Lys Phe

260 265 270

Phe Asp Ala Leu Glu Leu Glu Lys Glu Ser Glu Arg Phe Leu Asn Lys

275 280 285

Glu Ala Val Pro Thr Gly Leu Leu Asp Gly Lys Lys Ala Leu Tyr Ala

290 295 300

Lys Asn Leu Ser Leu Glu He Glu Lys Gly Phe Gin His Asn Leu Leu 305 310 315 320

Ser Gly His Ala Lys Thr Leu Gly Ser Arg Arg Phe Phe Trp Val Phe

325 330 335

Val Glu Asn He Thr Ser Gin Tyr He Lys Glu Lys Ala Gin Phe Glu

340 345 350

Leu Glu Phe Tyr Leu Pro Lys Gly Ser Tyr Ala Ser Ala Leu Leu Lys

355 360 365

Glu He Lys His Glu Lys Gly Glu Asn Asn Asp Glu Phe 370 375 380

(2) INFORMATION FOR SEQ ID NO: 938:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 697 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE: (A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...697

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 938 :

Leu Gin Asn Phe Val Phe Asn Lys Lys Trp Leu He Tyr Ser Ser Leu

1 5 10 15

Leu Pro Leu Phe Phe Leu Asn Pro Leu Met Ala Glu Asp Asp Gly Phe

20 25 30

Phe Met Gly Val Ser Tyr Gin Thr Ser Leu Ala Val Gin Arg Val Asp

35 40 45

Asn Ser Gly Leu Asn Ala Ser Gin Asp Ala Ser Thr Tyr He Arg Gin

50 55 60

Asn Ala He Ala Leu Glu Ser Ala Ala Val Pro Leu Ala Tyr Tyr Leu 65 70 75 80

Glu Ala Met Gly Gin Gin Thr Arg Val Leu Met Gin Met Leu Cys Pro

85 90 95

Asp Pro Ser Lys Arg Cys Leu Leu Tyr Ala Gly Gly Tyr Gin Asn Gly

100 105 110

Gin Asn Asn Asn Gly Asp Thr Gly Asn Asn Pro Pro Arg Gly Asn Val

115 120 125

Asn Ala Thr Phe Asp Met Gin Ser Leu Val Asn Asn Leu Asn Lys Leu

130 135 140

Thr Gin Leu He Gly Glu Thr Leu He Arg Asn Pro Glu Asn Leu Pro 145 150 155 160

Asn Ser Lys Val Phe Asn Val Lys Phe Gly Asn Gin Ser Thr Val He

165 170 175

Ala Leu Pro Glu Gly Leu Ala Asn Thr Met Asp Ala Leu Asn Asn Asp

180 185 190

He Thr Asn Ala Leu Thr Thr Leu Trp Tyr Asn Gin Thr Leu Thr Asn

195 200 205

Lys Ser Phe Ser Thr Pro Ser Asn Thr Ser Val Asn Phe Ser Pro Gin

210 215 220

Val Leu Gin His Leu Leu Gin Asp Gly Leu Ala Thr Ala Asn Asn Asn 225 230 235 240

Gin Thr He Cys Ser Thr Gin Asn Gin Cys Thr Ala Thr Asn Glu Ala

245 250 255

Lys Ser He Ala Gin Asn Ala Gin Asn He Phe Gin Ala Leu Met Gin

260 265 270

Ala Gly He Leu Gly Gly Leu Ala Asn Glu Lys Gin Phe Gly Phe Thr

275 280 285

Tyr Asn Lys Ala Pro Asn Gly Ser Asp Ser Gin Gin Gly Tyr Gin Ser

290 295 300

Phe Ser Gly Pro Gly Tyr Tyr Thr Lys Asn Asp Asn Thr Thr Gin Ala 305 310 315 320

Pro Leu Lys Ala Leu Pro Ala Gly Ala Thr He Gly Ser Gly Asn Gly

325 330 335

Gin Tyr Thr Tyr His Pro Ser Ser Ala Val Tyr Tyr Leu Ala Asp Ser

340 345 350

He He Ala Asn Gly He Thr Ala Ser Met He Phe Ser Gly Met Gin

355 360 365

Asn Phe Ala Asn Lys Ala Ala Lys Leu He Gly Thr Ser Ser Tyr Asn

370 375 380

Gin Met Gin Asp Val He Asn Tyr Gly Glu Ser Leu Leu Ser Asn Thr 385 390 395 400

Val Ala Tyr Gly Asp Phe He Thr Asn Trp Val Ala Pro Tyr Leu Asp

405 410 415

Leu Asn Asn Lys Gly Leu Asn Phe Leu Pro Asn Tyr Gly Gly Gin Leu

420 425 430

Asn Gly Ala Asn Asn Gin Thr Pro Gin Leu Thr Pro Gin Gin Ala Gin

435 440 445

Gin Glu Gin Lys Val He Met Asn Gin Leu Glu Gin Ala Thr Asn Ala

450 455 460

Pro Thr Pro Ala Gin He Asn Arg He Leu Ala Asn Pro Tyr Ser Pro 465 470 475 480

Thr Ala Lys Thr Leu Met Ala Tyr Gly Leu Tyr Arg Ser Lys Ala Val

485 490 495

He Gly Gly Val He Asp Glu Met Gin Thr Lys Val Asn Gin Val Tyr

500 505 510

Gin Met Gly Phe Ala Arg Asn Phe Leu Glu His Asn Ser Asn Ser Asn

515 520 525

Asn Met Asn Gly Phe Gly Val Lys Met Gly Tyr Lys Gin Phe Phe Gly

530 535 540

Lys Lys Arg Met Phe Gly Leu Arg Tyr Tyr Gly Phe Tyr Asp Phe Gly 545 550 555 560

Tyr Ala Gin Phe Gly Thr Glu Ser Ser Leu Val Lys Ala Thr Leu Ser

565 570 575

Ser Tyr Gly Ala Gly Thr Asp Phe Leu Tyr Asn Val Phe Thr Arg Lys

580 585 590

Arg Gly Thr Glu Ala He Asp He Gly Phe Phe Ala Gly He Gin Leu

595 600 605

Ala Gly Gin Thr Trp Lys Thr Asn Phe Leu Asp Gin Val Asp Gly Asn

610 615 620

His Leu Lys Pro Lys Asp Thr Ser Phe Gin Phe Leu Phe Asp Leu Gly 625 630 635 640

He Arg Thr Asn Phe Ser Lys He Ala His Gin Lys Arg Ser Arg Phe

645 650 655

Ser Gin Gly He Glu Phe Gly Leu Lys He Pro Val Leu Tyr His Thr

660 665 670

Tyr Tyr Gin Ser Glu Gly Val Thr Ala Lys Tyr Arg Arg Ala Phe Ser

675 680 685

Phe Tyr Val Gly Tyr Asn He Gly Phe 690 695

(2) INFORMATION FOR SEQ ID NO: 939:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 697 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...697 ( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 939 :

Leu Gin Asn Phe Val Phe Asn Lys Lys Trp Leu H e Tyr Ser Ser Leu

1 5 10 15

Leu Pro Leu Phe Phe Leu Asn Pro Leu Met Ala Glu Asp Asp Gly Phe

20 25 30

Phe Met Gly Val Ser Tyr Gin Thr Ser Leu Ala Val Gin Arg Val Asp

35 40 45

Asn Ser Gly Leu Asn Ala Ser Gin Asp Ala Ser Thr Tyr He Arg Gin

50 55 60

Asn Ala He Ala Leu Glu Ser Ala Ala Val Pro Leu Ala Tyr Tyr Leu 65 70 75 80

Glu Ala Met Gly Gin Gin Thr Arg Val Leu Met Gin Met Leu Cys Pro

85 90 95

Asp Pro Ser Lys Arg Cys Leu Leu Tyr Ala Gly Gly Tyr Gin Asn Gly

100 105 110

Gin Asn Asn Asn Gly Asp Thr Gly Asn Asn Pro Pro Arg Gly Asn Val

115 120 125

Asn Ala Thr Phe Asp Met Gin Ser Leu Val Asn Asn Leu Asn Lys Leu

130 135 140

Thr Gin Leu He Gly Glu Thr Leu He Arg Asn Pro Glu Asn Leu Pro 145 150 155 160

Asn Ser Lys Val Phe Asn Val Lys Phe Gly Asn Gin Ser Thr Val He

165 170 175

Ala Leu Pro Glu Gly Leu Ala Asn Thr Met Asp Ala Leu Asn Asn Asp

180 185 190

He Thr Asn Ala Leu Thr Thr Leu Trp Tyr Asn Gin Thr Leu Thr Asn

195 200 205

Lys Ser Phe Ser Thr Pro Ser Asn Thr Ser Val Asn Phe Ser Pro Gin

210 215 220

Val Leu Gin His Leu Leu Gin Asp Gly Leu Ala Thr Ala Asn Asn Asn 225 230 235 240

Gin Thr He Cys Ser Thr Gin Asn Gin Cys Thr Ala Thr Asn Glu Ala

245 250 255

Lys Ser He Ala Gin Asn Ala Gin Asn He Phe Gin Ala Leu Met Gin

260 265 270

Ala Gly He Leu Gly Gly Leu Ala Asn Glu Lys Gin Phe Gly Phe Thr

275 280 285

Tyr Asn Lys Ala Pro Asn Gly Ser Asp Ser Gin Gin Gly Tyr Gin Ser

290 295 300

Phe Ser Gly Pro Gly Tyr Tyr Thr Lys Asn Asp Asn Thr Thr Gin Ala 305 310 315 320

Pro Leu Lys Ala Leu Pro Ala Gly Ala Thr He Gly Ser Gly Asn Gly

325 330 335

Gin Tyr Thr Tyr His Pro Ser Ser Ala Val Tyr Tyr Leu Ala Asp Ser

340 345 350

He He Ala Asn Gly He Thr Ala Ser Met He Phe Ser Gly Met Gin

355 360 365

Asn Phe Ala Asn Lys Ala Ala Lys Leu He Gly Thr Ser Ser Tyr Asn

370 375 380

Gin Met Gin Asp Val He Asn Tyr Gly Glu Ser Leu Leu Ser Asn Thr 385 390 395 400

Val Ala Tyr Gly Asp Phe He Thr Asn Trp Val Ala Pro Tyr Leu Asp

405 410 415

Leu Asn Asn Lys Gly Leu Asn Phe Leu Pro Asn Tyr Gly Gly Gin Leu 420 425 430 Asn Gly Ala Asn Asn Gin Thr Pro Gin Leu Thr Pro Gin Gin Ala Gin

435 440 445

Gin Glu Gin Lys Val He Met Asn Gin Leu Glu Gin Ala Thr Asn Ala

450 455 460

Pro Thr Pro Ala Gin He Asn Arg He Leu Ala Asn Pro Tyr Ser Pro 465 470 475 480

Thr Ala Lys Thr Leu Met Ala Tyr Gly Leu Tyr Arg Ser Lys Ala Val

485 490 495

He Gly Gly Val He Asp Glu Met Gin Thr Lys Val Asn Gin Val Tyr

500 505 510

Gin Met Gly Phe Ala Arg Asn Phe Leu Glu His Asn Ser Asn Ser Asn

515 520 525

Asn Met Asn Gly Phe Gly Val Lys Met Gly Tyr Lys Gin Phe Phe Gly

530 535 540

Lys Lys Arg Met Phe Gly Leu Arg Tyr Tyr Gly Phe Tyr Asp Phe Gly 545 550 555 560

Tyr Ala Gin Phe Gly Thr Glu Ser Ser Leu Val Lys Ala Thr Leu Ser

565 570 575

Ser Tyr Gly Ala Gly Thr Asp Phe Leu Tyr Asn Val Phe Thr Arg Lys

580 585 590

Arg Gly Thr Glu Ala He Asp He Gly Phe Phe Ala Gly He Gin Leu

595 600 605

Ala Gly Gin Thr Trp Lys Thr Asn Phe Leu Asp Gin Val Asp Gly Asn

610 615 620

His Leu Lys Pro Lys Asp Thr Ser Phe Gin Phe Leu Phe Asp Leu Gly 625 630 635 640

He Arg Thr Asn Phe Ser Lys He Ala His Gin Lys Arg Ser Arg Phe

645 650 655

Ser Gin Gly He Glu Phe Gly Leu Lys He Pro Val Leu Tyr His Thr

660 665 670

Tyr Tyr Gin Ser Glu Gly Val Thr Ala Lys Tyr Arg Arg Ala Phe Ser

675 680 685

Phe Tyr Val Gly Tyr Asn He Gly Phe 690 695

(2) INFORMATION FOR SEQ ID NO: 940:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1237 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...1237

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 940:

Met He Lys Lys Ala Lys Lys Phe He Pro Leu Phe Leu He Gly Ser

1 5 10 15 Leu Leu Ala Glu Asp Asn Gly Trp Tyr Met Ser Val Gly Tyr Gin He

20 25 30

Gly Gly Thr Gin Gin Phe He Asn Asn Lys Gin Leu Leu Glu Asn Gin

35 40 45

Asn He He Asn Ser He Thr Gin Ser Ala He Asn He Ala Gly Pro

50 55 60

Thr Thr Gly Leu He Thr Leu Ser Ser Gin Ser Val He Asp Ala Leu 65 70 75 80

Gly Tyr Gly Val Ser Asn Thr Val Gly Asn Gin Leu Glu Gly He Ser

85 90 95

Asn He Leu Asn Gin He Gly Lys Arg Lys Asp Phe Tyr Ser Ser Arg

100 105 110

Gin He Ser Ser He Ser Gin Gin He He Gly Leu Lys Gly Ser Ser

115 120 125

Asp Pro Leu Lys Ala His Ser Ser Gin He Thr Ala Lys Leu Leu Ser

130 135 140

Asn Thr Gin Ser Ala Phe Asp Gin Gly He Ala Leu Ser Ser Asn He 145 150 155 160

He Ser Ala Val Asn Ser Leu Asn Pro Ser Asn Asn Ser Gin Glu Val

165 170 175

Lys Ala Gin Leu Gin Asn Thr Ala Gin Ser Met Thr Glu Leu Leu Gin

180 185 190

Gin He Glu His Ser He Thr Lys Thr Thr Ser Thr Thr Tyr Ala Gin

195 200 205

Ser Leu Leu Ser Asn Leu Thr Asp Ala Val Asn Ala Ser Ser Asn Asn

210 215 220

Thr Thr Tyr Val Ser Ala Leu Val Asn Ala Leu Asn Thr Leu Gly Val 225 230 235 240

Gly Val Phe Pro Thr Thr Thr Ser Thr His Val Val Leu Asn Pro Pro

245 250 255

Gly Gin Val Val Phe Tyr Pro Thr Asn Ser Leu Leu Gly Ser Thr Ser

260 265 270

Ser Asn Ser Asn Asn Gin Gin Gin Tyr Asn Asn Thr Leu Leu Met Asn

275 280 285

Thr Leu Gin Gly Glu Leu Ser Thr Asn Asn Gin Asn Asn Pro Asn Gly

290 295 300

Cys Ala Asn Gin He Gin Cys Leu Glu Gin Phe He Gin Asn Leu Thr 305 310 315 320

Pro Leu Ala Ala Thr Pro Thr Ser Thr Asn Gin Ala Asn Gin Gin Val

325 330 335

Gin Ala He Ala Gin Lys Leu Gin Ser Val Ala He Asn Ala Leu Asp

340 345 350

Asn Asn Ala He Asn Asn Thr Thr Tyr Asn Leu Asn Asn Leu His Asn

355 360 365

Ala Leu Asn Phe Gin Ala Tyr Gin Ser Thr He Glu Gin Tyr Asn Asn

370 375 380

Ala Leu Lys Gin He Ser Trp He Ser Phe Ser Glu Pro Lys Asn Leu 385 390 395 400

Leu Lys Asn Thr Ser Asn Asn Tyr Gin He Gly Thr Val Thr Asn Asp

405 410 415

Gin Gly Gin Asn He Ser Ala Tyr Asp Cys Thr Ser Ala Thr Gly Ser

420 425 430

Leu Ser Ser Asp Ala Ser Ser Gly He Ser Cys Ser Ala Thr Ser Ser

435 440 445

Thr Asn Asn Thr Asn Ser Phe Asp Asn Ser Leu Val Ala Thr Ser Lys

450 455 460

Val Gin Thr He Asn Gly Lys Glu Gin He Gly Val Asn Ser Phe Asn 465 470 475 480

Leu Val Ser Gin Val Trp Ser Val Tyr Asn Ser Leu Lys Thr Ser Glu

485 490 495

Glu Asn Leu Gin Lys Asn Ala Lys He Leu Cys Asn Asn Gly Ser Gin

500 505 510

Ser Gly Thr Ser Pro Cys Asn Ser Ser Ser Gly Gly Leu Ser He Ser

515 520 525

Gly Asn Ala Gin Leu Gin Asn He Leu Ser Pro Thr Asn Gly Thr Thr

530 535 540

Thr Asn Thr Gin Ala Lys Ser Asn Ala Ser Lys Leu Lys Ala Met Val 545 550 555 560

Met Val Asn Asn Glu Glu Glu Ala Lys Thr Thr Asn Phe Asn Gin Ser

565 570 575

Ser Gly Pro Thr Thr Gin Ser Ser Asn Ser Thr Val Met Gly Ala Leu

580 585 590

Asn Thr Val Leu Gin Asn Val Ser Asn Phe Gin Gin Ser He Gin Ser

595 600 605

Ala Phe Gin Asn Gin Glu Asn Asn He Gin Ala Trp Ala Asn Ala Leu

610 615 620

Tyr Asn Thr Ser Asn Pro Asn Gly Asn Gin Ser Gin Asn Leu Thr Thr 625 630 635 640

Asn Asn Asn Gin Asp Leu Arg He Gin Leu Arg Ala Asn Phe Tyr Gin

645 650 655

Leu He Asn Thr He Asn Gin Gin Val Pro Thr Asp Met Asn Ala Leu

660 665 670

He Asn Gin Ser Gin Gin Thr Gin Gin Thr Ser Gly Ser Ala Ser Thr

675 680 685

Thr Asn Asn Ala Cys Ala Ser Gly Met Gly Ser Ser Gly Asn Trp Cys

690 695 700

Tyr Gin Gin Trp Ser Asp Ser Lys Ala Tyr Tyr Ser Gly Leu Gin Ser 705 710 715 720

Ala Leu Gly Tyr Gin Thr Gin Ala Thr Thr Gin Asn Gly Ser Ser Gly

725 730 735

Gly Ser Asn He Thr Tyr Asn Val Gin Gin He Thr Leu Thr Ser Gly

740 745 750

Gly Leu Leu Asn Gin He He Thr Asn Leu Lys Ser Val Asn Gly Gly

755 760 765

Ser Asn Gly Gly Ser Ser Gly Asn Gly Thr Ser Gin He Asn Thr Ala

770 775 780

Tyr Gin Met Leu Thr Asp Ala Ser Asp Gly Lys Leu Gly Thr Tyr Asn 785 790 795 800

Ser Ser Asn Ser Ser Asn Ser Ser Asn Ser Gly Asn Asn Asn Gly Tyr

805 810 815

Thr Pro Cys Asn Ser Thr Asn Gly Ser Asn Gly Thr Ser Gly Ser Asn

820 825 830

Cys Tyr Glu Pro Asn Lys Gin Gin Asn Ala Thr Thr Ala Thr Thr Thr

835 840 845

Thr Asp Ser Asn Leu Gin Lys Val Tyr Asn Asp Ala Gin Lys He Ala

850 855 860

Asn He He Ala Ser Ser Gly Asn Asn Lys Gly Val Glu Asn Gly Leu 865 870 875 880

Lys Gin Phe Phe Glu Ala Leu Lys Ser Asn Ser Ser Ser Leu Ser Asn

885 890 895

Leu Cys Gly Asn Gly Ser Ser Gly Ser Ser Ser Thr Cys Ser Gly Gly

900 905 910

Leu He Asn Leu Leu Gly Ala He Pro Thr Asn Gly Val Ser Asp Thr 915 920 925 Asn Asn Leu He Asn Leu Leu Thr Glu Phe He Lys Thr Ala Gly Phe

930 935 940

He Gin Asn Asn Asp Ser Asn Val Ser Thr Ser Leu Thr Ser Ala Phe 945 950 955 960

Gin Ala He Thr Ser Ala He Ser Gin Gly Phe Gin Ala Leu Gin Asn

965 970 975

Asp He Ser Pro Asn Ala He Leu Thr Leu Leu Gin Glu He Thr Ser

980 985 990

Asn Thr Thr Thr He Gin Ser Phe Ser Gin Thr Leu Arg Gin Leu Leu

995 1000 1005

Gly Asp Lys Thr Phe Phe Met Val Gin Gin Lys Leu He Asp Ala Met

1010 1015 1020

He Asn Ala Arg Asn Gin Val Gin Asn Ala Gin Asn Gin Ala Asn Asn 1025 1030 1035 1040

Tyr Gly Ser Gin Pro Val Leu Ser Gin Tyr Ala Ala Gly Lys Ser Thr

1045 1050 1055

Gin His Gly Met Ser Asn Gly Leu Gly Val Gly He Gly Tyr Lys Tyr

1060 1065 1070

Phe Phe Gly Lys Ala Arg Lys Leu Gly Leu Arg His Tyr Phe Phe Phe

1075 1080 1085

Asp Tyr Gly Phe Ser Glu He Gly Leu Ala Asn Gin Ser Val Lys Ala

1090 1095 1100

Asn He Phe Ala Tyr Gly Val Gly Thr Asp Phe Leu Trp Asn Leu Phe 1105 1110 1115 1120

Arg Arg Thr Tyr Asn Thr Lys Ala Leu Asn Phe Gly Leu Phe Ala Gly

1125 1130 1135

Val Gin Leu Gly Gly Ala Thr Trp Leu Ser Ser Leu Arg Gin Gin He

1140 1145 1150

He Asp Asn Trp Gly Asn Ala Asn Asp He His Ser Thr Asn Phe Gin

1155 1160 1165

Val Ala Leu Asn Phe Gly Val Arg Thr Asn Phe Ala Glu Phe Lys Arg

1170 1175 1180

Phe Ala Lys Lys Phe His Asn Gin Gly Val He Ser Gin Lys Ser Val 1185 1190 1195 1200

Glu Phe Gly He Lys Val Pro Leu He Asn Gin Ala Tyr Leu Asn Ser

1205 1210 1215

Ala Gly Ala Asp Val Ser Tyr Arg Arg Leu Tyr Thr Phe Tyr He Asn

1220 1225 1230

Tyr He Met Gly Phe 1235

(2) INFORMATION FOR SEQ ID NO: 941:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 171 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature ( B ) LOCATION 1 . . . 171

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 941 :

Met Glu Lys Leu Pro Lys Lys Arg Val Ser Lys Thr Lys Ser Gin Lys

1 5 10 15

Leu He His Ser Leu Thr Thr Gin Lys Asn Arg Ala Phe Leu Gin Lys

20 25 30

Thr Ser Ala Asn Glu Met Leu Leu Glu Leu Glu Lys Gly Ala Phe Lys

35 40 45

Lys Asn Glu Ala Tyr Phe He Ser Asp Glu Glu Asp Lys Asn Tyr Val

50 55 60

Leu Val Pro Asp Asn Val He Ser Leu Leu Ala Glu Asn Ala Arg Lys 65 70 75 80

Ala Phe Glu Ala Arg Leu Arg Ala Glu Leu Glu Arg Asp He He Thr

85 90 95

Gin Ala Pro He Asp Phe Glu Asp Val Arg Glu Val Ser Leu Gin Leu

100 105 110

Leu Glu Asn Leu Arg Gin Lys Asp Gly Asn Leu Pro Asn He Asn Thr

115 120 125

Leu Asn Phe Val Lys Gin He Lys Lys Glu His Pro Asn Leu Phe Phe

130 135 140

Asn Phe Asp Asn Met Phe Lys Gin Pro Pro Phe Asn Glu Asn Asn Phe 145 150 155 160

Glu Asn Phe Asp Asn Ser Asp Glu Glu Asn Phe 165 170

(2) INFORMATION FOR SEQ ID NO: 942:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 435 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...435

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 942 :

Met Lys Lys He Leu He Thr Leu He Thr Leu Leu Leu Gly Val Phe

1 5 10 15

Met Gly Leu Gin Ala Ser Ala Leu Thr His Gin Glu He Asn Gin Ala

20 25 30

Lys Val Pro Val He Tyr Glu Glu Asn His Leu Leu Pro Met Gly Phe

35 40 45

He His Leu Ala Phe Arg Gly Gly Gly Ser Leu Ser Asp Lys Asn Gin

50 55 60

Leu Gly Leu Ala Lys Leu Phe Ala Gin Val Leu Asn Glu Gly Thr Lys 65 70 75 80 Glu Leu Gly Ala Val Gly Phe Ala Gin Leu Leu Glu Gin Lys Ala He

85 90 95

Ser Leu Asn Val Asp Thr Ser Ala Glu Asp Leu Gin He Thr Leu Glu

100 105 110

Phe Leu Lys Glu Tyr Glu Asp Glu Ala He Met Arg Leu Lys Glu Leu

115 120 125

Leu Lys Ser Pro Asn Phe Thr Gin Asn Ala Leu Glu Lys Val Lys Thr

130 135 140

Arg Met Leu Ala Gin Leu Leu Gin Lys Glu Ser Asp Phe Asp Tyr Leu 145 150 155 160

Ala Lys Leu Thr Leu Lys Gin Glu Leu Phe Ala Asn Thr Pro Leu Ala

165 170 175

Asn Ala Ala Leu Gly Thr Lys Glu Ser Leu Gin Lys He Lys Leu Asp

180 185 190

Asp Leu Lys Gin Gin Phe Ala Lys Val Phe Glu Leu Asn Lys Leu Val

195 200 205

Val Val Leu Gly Gly Asp Leu Lys Val Asn Gin Thr Leu Asn Arg Leu

210 215 220

Asn Asn Ala Leu Asn Phe Leu Pro Gin Gly Lys Ala Tyr Glu Glu Pro 225 230 235 240

Tyr Phe Glu Ala Ser Asp Lys Lys Ser Glu Lys Val Leu Tyr Lys Asp

245 250 255

Thr Glu Gin Ala Phe Val Tyr Phe Gly Val Pro Phe Lys He Lys Asp

260 265 270

Leu Lys Gin Asp Leu Ala Lys Ser Lys Val Met Met Phe Val Leu Gly

275 280 285

Gly Gly Phe Gly Ser Arg Leu Met Glu Lys He Arg Val Gin Glu Gly

290 295 300

Leu Ala Tyr Ser Val Tyr He Arg Ser Asn Phe Ser Lys Val Ala His 305 310 315 320

Phe Ala Ser Gly Tyr Leu Gin Thr Lys Leu Ser Thr Gin Ala Lys Ser

325 330 335

Val Ala Leu Val Lys Lys He He Lys Glu Phe He Glu Lys Gly Met

340 345 350

Thr Gin Gin Glu Leu Asp Asp Ala Lys Lys Phe Leu Leu Gly Ser Glu

355 360 365

Pro Leu Arg Asn Glu Thr He Ser Ser Arg Leu Asn Thr Thr Tyr Asn

370 375 380

Tyr Phe Tyr Leu Gly Leu Pro Leu Asp Phe Asn Gin Thr Leu Leu Asn 385 390 395 400

Gin He Gin Lys Met Ser Leu Lys Glu He Asn Asp Phe He Lys Glu

405 410 415

His Thr Glu He Asn Asp Leu Thr Phe Ala He Val Ser Asn Lys Lys

420 425 430

Lys Asp Lys 435

(2) INFORMATION FOR SEQ ID NO: 943:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 614 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 614

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 943:

Leu Ala Ser Pro Lys Glu Thr Pro Lys Glu Ala Gin Lys Asn Glu Ala

1 5 10 15

Gin Asn Glu Thr Ser Gin Ser Asn Gin Thr Pro Lys Glu Met Lys Val

20 25 30

Lys Ser He Ser Tyr Val Gly Leu Ser Tyr Met Ser Asp Met Leu Ala

35 40 45

Asn Glu He Ala Lys He Arg Val Gly Asp Met Val Asp Ser Lys Lys

50 55 60

He Asp Thr Ala Val Leu Ala Leu Phe Asn Gin Gly Tyr Phe Lys Asp 65 70 75 80

Val Tyr Ala Thr Phe Glu Asn Gly He Leu Glu Phe His Phe Asp Glu

85 90 95

Lys Ala Arg He Ala Gly Val Glu He Lys Gly Tyr Gly Thr Glu Lys

100 105 110

Glu Lys Asp Gly Leu Lys Ser Gin Met Gly He Lys Lys Gly Asp Thr

115 120 125

Phe Asp Glu Gin Lys Leu Glu His Ala Lys Thr Ala Leu Lys Thr Ala

130 135 140

Leu Glu Gly Gin Gly Tyr Tyr Gly Ser Val Val Glu Val Arg Thr Glu 145 150 155 160

Lys Val Ser Glu Gly Ala Leu Leu He Val Phe Asp Val Asn Arg Gly

165 170 175

Asp Ser He Tyr He Lys Gin Ser He Tyr Glu Gly Ser Asp Lys Leu

180 185 190

Lys Arg Arg Val He Glu Ser Leu Ser Ala Asn Lys Gin Arg Asp Phe

195 200 205

Met Gly Trp Met Trp Gly Leu Asn Asp Gly Lys Leu Arg Leu Asp Gin

210 215 220

Leu Glu Tyr Asp Ser Leu Arg He Gin Asp Val Tyr Met Arg Arg Gly 225 230 235 240

Tyr Leu Asp Ala His He Ser Ser Pro Phe Leu Lys Thr Asp Phe Ser

245 250 255

Thr His Asp Ala Lys Leu His Tyr Lys Val Lys Glu Gly He Gin Tyr

260 265 270

Arg He Ser Asp He Leu He Glu He Asp Asn Pro Val Val Pro Leu

275 280 285

Lys Thr Leu Glu Lys Ala Leu Lys Val Lys Arg Lys Asp Val Phe Asn

290 295 300

He Glu His Leu Arg Ala Asp Ala Gin He Leu Lys Thr Glu He Ala 305 310 315 320

Asp Lys Gly Tyr Ala Phe Ala Val Val Lys Pro Asp Leu Asp Lys Asp

325 330 335

Glu Lys Asn Gly Leu Val Lys Val He Tyr Arg He Glu Val Gly Asp

340 345 350

Met Val His He Asn Asp Val He He Ser Gly Asn Gin Arg Thr Ser

355 360 365

Asp Arg He He Arg Arg Glu Leu Leu Leu Gly Pro Lys Asp Lys Tyr 370 375 380

Asn Leu Thr Lys Leu Arg Asn Ser Glu Asn Ser Leu Arg Arg Leu Gly 385 390 395 400

Phe Phe Ser Lys Val Lys He Glu Glu Lys Arg Val Asn Ser Ser Leu

405 410 415

Met Asp Leu Leu Val Ser Val Glu Glu Gly Arg Thr Gly Gin Leu Gin

420 425 430

Phe Gly Leu Gly Tyr Gly Ser Tyr Gly Gly Leu Met Leu Asn Gly Ser

435 440 445

Val Ser Glu Arg Asn Leu Phe Gly Thr Gly Gin Ser Met Ser Leu Tyr

450 455 460

Ala Asn He Ala Thr Gly Gly Gly Arg Ser Tyr Pro Gly Met Pro Lys 465 470 475 480

Gly Ala Gly Arg Met Phe Ala Gly Asn Leu Ser Leu Thr Asn Pro Arg

485 490 495

He Phe Asp Ser Trp Tyr Ser Ser Thr He Asn Leu Tyr Ala Asp Tyr

500 505 510

Arg He Ser Tyr Gin Tyr He Gin Gin Gly Gly Gly Phe Gly Val Asn

515 520 525

Val Gly Arg Met Leu Gly Asn Arg Thr His Val Ser Leu Gly Tyr Asn

530 535 540

Leu Asn Val Thr Lys Leu Leu Gly Phe Ser Ser Pro Leu Tyr Asn Arg 545 550 555 560

Tyr Tyr Ser Ser Val Asn Glu Val Ala Ser Pro Arg Gin Cys Ser Thr

565 570 575

Pro Ala Ser Val He He Asn Arg Leu Ser Gly Gly Arg Thr Pro Leu

580 585 590

Val Pro Glu Ser Cys Ser Ser Pro Gly Ala He Thr He Phe Thr Arg

595 600 605

Asn Lys Arg Tyr Leu Gly 610

(2) INFORMATION FOR SEQ ID NO: 944:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 376 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B) LOCATION 1 . . . 376

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 944 :

Leu Cys Glu Gly Pro Asn Val Met Ser Gly Trp Lys Pro His He Lys

1 5 10 15

His Gly Val Tyr Arg Asn Trp Asn Asn Trp Arg Asn Asn Tyr Thr Ala

20 25 30

Val Tyr Leu Ser Asp Arg He Glu Ala Trp Asp Gly Arg Phe Phe He 35 40 45

Val Pro Gly Leu Arg Tyr Ala Phe Val Gin Tyr Asn Asn Glu Asn Ala

50 55 60

Ser Asn Trp Met Gin He Pro Glu Lys Asp Leu Arg Lys He Lys His 65 70 75 80

Met Asn Asn Trp Met Pro Ser Thr Asn He Gly Phe He Pro Val Gin

85 90 95

Gly Asp His Asn Val Leu Thr Tyr Phe Asn Tyr Gin Arg Ser Phe Val

100 105 110

Pro Pro Gin Leu Asp Val Leu Ser Tyr Gly Gly Ala Glu Tyr Phe Thr

115 120 125

Gin His Phe Asp Thr Val Glu Ala Gly Ala Arg Tyr Thr Tyr Lys Asp

130 135 140

Lys Phe Ser Phe Asn Ala Asp Tyr Phe Arg He Trp Ala Arg Asp Phe 145 150 155 160

Ala Thr Gly Gin Tyr Ser Val Tyr Thr Ser Gly Pro Met Lys Gly Asn

165 170 175

Val Arg Pro He Asn Gly Tyr Ser Gin Gly Val Glu Leu Glu Leu Tyr

180 185 190

Tyr Arg Pro He Arg Gly Leu Gin Phe His Ala Ala Phe Asn Tyr He

195 200 205

Asp Thr Arg Val Thr Ser His Gly Pro Leu Thr Asp Leu Asn Gly Asp

210 215 220

Val Leu Lys Gly Thr Ser Tyr Asn Lys His Phe Pro Phe Val Ser Pro 225 230 235 240

Phe Gin Phe He Phe Asp Ala Arg Tyr Asn Trp Arg Lys Thr Thr He

245 250 255

Gly He Ser Ser Tyr Phe Tyr Ser Arg Ala Tyr Ser Gly He Ser Asn

260 265 270

Ser Ala Ala Gly Gly Tyr Tyr Gly Met Gin Tyr Tyr Ser Gly Gly Asn

275 280 285

Asn Tyr Glu Ser Val Leu Asn Ser Gly Tyr Gin Cys Glu Ala Trp Cys

290 295 300

Met Thr Gin His Glu Gly Leu Leu Pro Trp Tyr Trp Val Trp Asn He 305 310 315 320

Gin Val Ser Gin He Phe Trp Glu Asn Gly Arg His Arg Val Thr Gly

325 330 335

Ser Leu Gin He Asn Asn He Phe Asn Met Lys Tyr Tyr Phe Thr Gly

340 345 350

He Gly Ser Ser Pro Ala Gly Leu Gin Pro Ala Pro Gly Arg Ser Val

355 360 365

Thr Ala Tyr Leu Asn Tyr Thr Phe 370 375

(2) INFORMATION FOR SEQ ID NO: 945:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 621 ammo acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori ( ix ) FEATURE :

(A) NAME/KEY: miscjeature

(B) LOCATION 1...621

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 945 :

Leu Hi s Ala Glu Asp Asn Gly Phe Phe Val Ser Ala Gly Tyr Gin He

1 5 10 15

Gly Glu Ala Val Gin Met Val Lys Asn Thr Gly Glu Leu Lys Asn Leu

20 25 30

Asn Asp Lys Tyr Glu Gin Leu Ser Gin Ser Leu Ala Gin Leu Ala Ser

35 40 45

Leu Lys Lys Ser He Gin Thr Ala Asn Asn He Gin Ala Val Asn Asn

50 55 60

Ala Leu Ser Asp Leu Lys Ser Phe Ala Ser Asn Asn His Thr Asn Lys 65 70 75 80

Glu Thr Ser Pro He Tyr Asn Thr Ala Gin Ala Val He Thr Ser Val

85 90 95

Leu Ala Phe Trp Ser Leu Tyr Ala Gly Asn Ala Leu Ser Phe His Val

100 105 110

Thr Gly Leu Asn Asp Gly Ser Asn Ser Pro Leu Gly Arg He His Arg

115 120 125

Asp Gly Asn Cys Thr Gly Leu Gin Gin Cys Phe Met Ser Lys Glu Thr

130 135 140

Tyr Asp Lys Met Lys Thr Leu Ala Glu Asn Leu Gin Lys Ala Gin Gly 145 150 155 160

Asn Leu Cys Ala Leu Ser Glu Cys Ser Ser Asn Gin Ser Asn Gly Gly

165 170 175

Lys Thr Ser Met Thr Thr Ala Leu Gin Thr Ala Gin Gin Leu Met Asp

180 185 190

Leu He Glu Gin Thr Lys Val Ser Met Val Trp Lys Asn He Val He

195 200 205

Ala Gly Val Thr Asn Lys Pro Asn Gly Ala Gly Ala He Thr Ser Thr

210 215 220

Gly His Val Thr Asp Tyr Ala Val Phe Asn Asn He Lys Ala Met Leu 225 230 235 240

Pro He Leu Gin Gin Ala Leu Thr Leu Ser Gin Ser Asn His Thr Leu

245 250 255

Ser Thr Gin Leu Gin Ala Arg Ala Met Gly Ser Gin Thr Asn Arg Glu

260 265 270

Phe Ala Lys Asp He Tyr Ala Leu Ala Gin Asn Gin Lys Gin He Leu

275 280 285

Ser Asn Ala Ser Ser He Phe Asn Leu Phe Asn Ser He Pro Lys Asp

290 295 300

Gin Leu Lys Tyr Leu Glu Asn Ala Tyr Leu Lys Val Pro His Leu Gly 305 310 315 320

Lys Thr Pro Thr Asn Pro Tyr Arg Gin Asn Val Asn Leu Asn Lys Glu

325 330 335

He Asn Ala Val Gin Asp Asn Val Ala Asn Tyr Gly Asn Arg Leu Asp

340 345 350

Ser Ala Leu Ser Val Ala Lys Asp Val Tyr Asn Leu Lys Ser Asn Gin

355 360 365

Thr Glu He Val Thr Thr Tyr Asn Asp Ala Lys Asn Leu Ser Glu Glu

370 375 380

He Ser Lys Leu Pro Tyr Asn Gin Val Asn Val Thr Asn He Val Met 385 390 395 400 Ser Pro Lys Asp Ser Thr Ala Gly Gin Tyr Gin He Asn Pro Glu Gin

405 410 415

Gin Ser Asn Leu Asn Gin Ala Leu Ala Ala Met Ser Asn Asn Pro Phe

420 425 430

Lys Lys Val Gly Met He Ser Ser Gin Asn Asn Asn Gly Ala Leu Asn

435 440 445

Gly Leu Gly Val Gin Val Gly Tyr Lys Gin Phe Phe Gly Glu Ser Lys

450 455 460

Arg Trp Gly Leu Arg Tyr Tyr Gly Phe Phe Asp Tyr Asn His Gly Tyr 465 470 475 480

He Lys Ser Ser Phe Phe Asn Ser Ser Ser Asp He Trp Thr Tyr Gly

485 490 495

Gly Gly Ser Asp Leu Leu Val Asn Phe He Asn Asp Ser He Thr Arg

500 505 510

Lys Asn Asn Lys Leu Ser Val Gly Leu Phe Gly Gly He Gin Leu Ala

515 520 525

Gly Thr Thr Trp Leu Asn Ser Gin Tyr Met Asn Leu Thr Ala Phe Asn

530 535 540

Asn Pro Tyr Ser Ala Lys Val Asn Ala Ser Asn Phe Gin Phe Leu Phe 545 550 555 560

Asn Leu Gly Leu Arg Thr Asn Leu Ala Thr Ala Lys Lys Lys Asp Ser

565 570 575

Glu Arg Ser Ala Gin His Gly Val Glu Leu Gly He Lys He Pro Thr

580 585 590

He Asn Thr Asn Tyr Tyr Ser Phe Leu Gly Thr Lys Leu Glu Tyr Arg

595 600 605

Arg Leu Tyr Ser Val Tyr Leu Asn Tyr Val Phe Ala Tyr 610 615 620

(2) INFORMATION FOR SEQ ID NO: 946:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 163 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...163

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 946 :

Met Met Arg Glu He Leu Thr Asn Arg Phe Phe Pro Ser Leu Phe Lys

1 5 10 15

Lys Arg Leu Asp Phe Ser Asn Arg Val Val Leu Gly Leu Gly Ser Asn

20 25 30

Leu Lys Asn Pro Leu Lys He Leu Lys Ser Cys Phe Leu Tyr Phe Lys

35 40 45

Asn His Ser Lys He Gly Lys He Phe Ser Ser Pro He Tyr He Asn 50 55 60 Pro Pro Phe Gly Tyr Thr Asn Gin Pro Asn Phe Tyr Asn Ala Thr He 65 70 75 80

He Leu Lys Thr Ser Leu Gly Leu Arg His Phe Phe Ala Leu Val Phe

85 90 95

Tyr He Glu Arg Arg Phe Gly Arg Ala Arg Lys Arg Asp Phe Lys Asp

100 105 110

Ala Pro Arg Thr Leu Asp He Asp He He Ala Phe Asn Gin Val He

115 120 125

Leu Arg Gin Asn Asp Leu Thr Leu Pro His Pro Lys Trp Ser Glu Arg

130 135 140

Asp Ser Val Leu Val Pro Leu Thr Leu Gin Gin He Leu Phe Lys Arg 145 150 155 160

Glu Glu Trp

(2) INFORMATION FOR SEQ ID NO: 947:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 285 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 285

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO -. 947 :

Met Gin Asp Phe He Lys He Phe He Gin Glu Val Val Ser Thr Leu

1 5 10 15

Glu Gly Leu Val Gly Lys Ala Pro Ser Val Gly Leu Glu Lys Glu Val

20 25 30

Ser Asn Asn Glu Glu Ala Ser Leu He Ser Thr Pro Tyr Ala Arg Val

35 40 45

Lys He Ser Ala He Glu Lys Asn Glu Ser Pro He Glu Leu Leu Ala

50 55 60

Pro Val Asp Leu Val Thr Ala Leu Ser Asp Leu Met Leu Gly Gly Glu 65 70 75 80

Gly Ala Ser Lys Glu Glu Met Asp Asn Asp Asp Leu Asp Ala Phe Lys

85 90 95

Glu Met Ala Ser Asn He Phe Gly Ala He Ala Thr Ser Leu Lys Ser

100 105 110

Gin Glu Leu Leu Pro Lys Leu Asn Phe Thr Thr Thr Asn Ala Glu He

115 120 125

Ala Lys Glu Leu Pro Lys Lys Glu Asp Tyr Ala Lys Ala Met Val Phe

130 135 140

Ser Phe Lys Met Glu Ala He Lys Glu Ser Gin He Val Leu Leu He 145 150 155 160

Thr Ser Ala Phe Glu Gly Gin Phe Glu Lys Thr His Lys Glu Glu Lys 165 170 175 Glu Glu Thr Thr Lys Ser Ala Thr Glu Glu Thr Lys Thr His Asp Ala

180 185 190

Ser Leu Glu Asn He Glu He Arg Asn He Ser Met Leu Leu Asp Val

195 200 205

Lys Leu Asn Val Lys Val Arg He Gly Gin Lys Lys Met He Leu Lys

210 215 220

Asp Val Val Ser Met Asp He Gly Ser Val Val Glu Leu Asp Gin Leu 225 230 . 235 240

Val Asn Asp Pro Leu Glu He Leu Val Asp Asp Lys Val He Ala Lys

245 250 255

Gly Glu Val Val He Val Asp Gly Asn Phe Gly He Gin He Thr Asp

260 265 270

He Gly Thr Lys Lys Glu Arg Leu Glu Gin Leu Lys Asn 275 280 285

(2) INFORMATION FOR SEQ ID NO: 948:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 170 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...170

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 948 :

Met Lys He Leu Val He Gin Gly Pro Asn Leu Asn Met Leu Gly His

1 5 10 15

Arg Asp Pro Arg Leu Tyr Gly Met Val Thr Leu Asp Gin He His Glu

20 25 30

He Met Gin Thr Phe Val Lys Gin Gly Asn Leu Asp Val Glu Leu Glu

35 40 45

Phe Phe Gin Thr Asn Phe Glu Gly Glu He He Asp Lys He Gin Glu

50 55 60

Ser Val Gly Ser Asp Tyr Glu Gly He He He Asn Pro Gly Ala Phe 65 70 75 80

Ser His Thr Ser He Ala He Ala Asp Ala He Met Leu Ala Gly Lys

85 90 95

Pro Val He Glu Val His Leu Thr Asn He Gin Ala Arg Glu Glu Phe

100 105 110

Arg Lys Asn Ser Tyr Thr Gly Ala Ala Cys Gly Gly Val He Met Gly

115 120 125

Phe Gly Pro Leu Gly Tyr Asn Met Ala Leu Met Ala Met Val Asn He

130 135 140

Leu Ala Glu Met Lys Ala Phe Gin Glu Ala Gin Lys Asn Asn Pro Asn 145 150 155 160

Asn Pro Asn Asn Pro He Asn Asn Gin Lys 165 170 (2) INFORMATION FOR SEQ ID NO: 949:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 357 ammo acids

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...357

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 949:

Met Arg Gly Leu Glu Arg Glu Ser His Phe Thr Leu Asn Glu Asn Ala

1 5 10 15

Met Phe Phe Glu Cys Ala Tyr Ser Cys Asp Asn Ala Leu Phe Leu Gin

20 25 30

Leu Asp Asp Arg Ser Phe Phe He Thr Asp Ser Arg Tyr Thr Gin Glu

35 40 45

Ala Lys Glu Ser Leu Gin Pro Lys Lys Gly Val Leu Val Glu Val He

50 55 60

Glu Ser Ser Asp Leu Val Gin Ser Ala He Asp Leu He Thr Lys Ser 65 70 75 80

Ser Val Lys Lys Leu Phe Phe Asp Pro Asn Gin Val Asn Leu Gin Thr

85 90 95

Tyr Lys Arg Leu Asp Ser Ala Val Gly Asn Lys Val Val Leu Glu Gly

100 105 110

Val Pro Ser Tyr His Arg Gin Lys Arg He He Lys Asn Glu His Glu

115 120 125

He Gin Leu Leu Lys Lys Ser Gin Ala Leu Asn Val Glu Ala Phe Glu

130 135 140

Asn Phe Ala Glu Tyr Val Lys Lys He Phe Asp Glu Lys Glu Ser Leu 145 150 155 160

Ser Glu Arg Tyr Leu Gin His Lys Val Lys Asp Phe Leu Thr Lys Glu

165 170 175

Gly Val Tyr Asp Leu Ser Phe Glu Pro He Leu Ala Leu Asn Ala Asn

180 185 190

Ala Ser Lys Pro His Ala Leu Pro Ser Ala Lys Asp Phe Leu Lys Ala

195 200 205

Asp His Ser He Leu Leu Asp Met Gly He Lys Tyr Glu Arg Tyr Cys

210 215 220

Ser Asp Arg Thr Arg Thr Ala Phe Phe Asp Pro Lys Asp Phe Val Phe 225 230 235 240

Lys Arg Glu Gin Ser Phe Lys Asp Lys Glu Arg Gin Lys He Tyr Asp

245 250 255

He Val Lys Glu Ala Gin Glu Lys Ala He Ser Gly He Arg Ala Gly

260 265 270

Met Thr Gly Lys Glu Ala Asp Ser Leu Ala Arg Gly Val He Ser Asp 275 280 285 Tyr Gly Tyr Gly Gin Tyr Phe Thr His Ser Thr Gly His Gly He Asp

290 295 300

Leu Asp He His Glu Leu Pro Tyr He Ser Ser Arg Ser Glu Thr He 305 310 315 320

Leu Glu Glu Gly Met Val Phe Ser Val Glu Pro Gly He Tyr He Pro

325 330 335

Gly Phe Phe Gly Val Arg He Glu Asp Leu Val Val He Lys Asn Ser

340 345 350

Arg Ala Glu Leu Leu 355

(2) INFORMATION FOR SEQ ID NO: 950:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 385 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...385

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 950:

Met Lys Asp Ser Phe Leu Phe Thr Ser Glu Ser Val Thr Glu Gly His

1 5 10 15

Pro Asp Lys Met Ala Asp Gin He Ser Asp Ala Val Leu Asp Tyr He

20 25 30

He Glu Arg Asp Lys Lys Ala Lys Val Ala Cys Glu Thr Leu Val Ser

35 40 45

Asn Gly Phe Cys Met He Thr Gly Glu Leu Lys Thr Ser Val Tyr Ala

50 55 60

Pro Met Gin Glu He Ala Arg Glu Val Val Lys Lys He Gly Tyr Thr 65 70 75 80

Asp Ala Leu Tyr Gly Phe Asp Tyr Arg Ser Ala Ala Val Leu Asn Gly

85 90 95

He Gly Glu Gin Ser Pro Asp He Asn Gin Gly Val Asp Arg Glu Asp

100 105 110

Gly Glu He Gly Ala Gly Asp Gin Gly Leu Met Phe Gly Tyr Ala Cys

115 120 125

Lys Glu Thr Glu Thr Leu Met Pro Leu Pro He His Leu Ala His Gin

130 135 140

Leu Ala Phe Ala Leu Ala Gin Lys Arg Lys Asp Asn Thr Leu Pro Phe 145 150 155 160

Leu Arg Pro Asp Gly Lys Ser Gin Val Ser Val Arg Tyr Glu Asn Asn

165 170 175

Lys Pro Val Ser Val Asp Thr He Val He Ser Thr Gin His Ser Pro

180 185 190

Glu Val Ser Gin Lys His Leu Lys Glu Ala Val He Glu Glu He Val 195 200 205 Tyr Lys Val Leu Pro Lys Glu Tyr Leu His Asp Asn He Lys Phe Phe

210 215 220

He Asn Pro Thr Gly Lys Phe Val He Gly Gly Pro Gin Gly Asp Ala 225 230 235 240

Gly Leu Tnr Gly Arg Lys He He Val Asp Thr Tyr Gly Gly Phe Cys

245 250 255

Pro His Gly Gly Gly Ala Phe Ser Gly Lys Asp Pro Ser Lys Val Asp

260 265 270

Arg Ser Ala Ala Tyr Ala Ala Arg Tyr Val Ala Lys Asn Leu Val Ala

275 280 285

Ser Gly Val Cys Asp Lys Ala Thr Val Gin Leu Ala Tyr Ala He Gly

290 295 300

Val He Glu Pro Val Ser He Tyr Val Asn Thr His Asn Thr Ser Lys 305 310 315 320

His Ser Ser Ala Glu Leu Glu Lys Cys Val Lys Ser Val Phe Lys Leu

325 330 335

Thr Pro Lys Gly He He Glu Ser Leu Asp Leu Leu Arg Pro He Tyr

340 345 350

Ser Leu Thr Ser Ala Tyr Gly His Phe Gly Arg Glu Leu Glu Glu Phe

355 360 365

Thr Trp Glu Lys Thr Asn Lys Val Glu Glu He Lys Ala Phe Phe Lys

370 375 380

Arg 385

(2) INFORMATION FOR SEQ ID NO: 951:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 218 ammo acids

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...218

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 951 :

Val Leu Asp Ser Phe Glu He Leu Lys Ala Leu Lys Ser Leu Asp Leu

1 5 10 15

Leu Lys Asn Ala Pro Ala Trp Trp Trp Pro Asn Ala Leu Lys Phe Glu

20 25 30

Ala Leu Leu Gly Ala Val Leu Thr Gin Asn Thr Lys Phe Glu Ala Val

35 40 45

Leu Lys Ser Leu Glu Asn Leu Lys Asn Ala Phe He Leu Glu Asn Asp

50 55 60

Asp Glu He Asn Leu Lys Lys He Ala Tyr He Glu Phe Ser Lys Leu

65 70 75 80

Ala Glu Cys Val Arg Pro Ser Gly Phe Tyr Asn Gin Lys Ala Lys Arg 85 90 95 Leu He Asp Leu Ser Lys Asn He Leu Lys Asp Phe Gin Ser Phe Glu

100 105 110

Asn Phe Lys Gin Glu Val Thr Lys Glu Trp Leu Leu Asp Gin Lys Gly

115 120 125

He Gly Lys Glu Ser Ala Asp Ala He Leu Cys Tyr Val Cys Ala Lys

130 135 140

Glu Val Met Val Val Asp Lys Tyr Ser Tyr Leu Phe Leu Lys Lys Leu 145 150 155 160

Gly He Glu He Glu Asp Tyr Asp Glu Leu Gin His Phe Phe Glu Lys

165 170 175

Gly Val Gin Glu Asn Leu Asn Ser Ala Leu Ala Leu Tyr Glu Asn Thr

180 185 190

He Ser Leu Ala Gin Leu Tyr Ala Arg Phe His Gly Lys He Val Glu

195 200 205

Phe Ser Lys Gin Lys Leu Glu Leu Lys Leu 210 215

(2) INFORMATION FOR SEQ ID NO: 952:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 132 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...132

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 952 :

Met Lys Gin Leu Phe Leu He He Gly Ala Pro Gly Ser Gly Lys Thr

1 5 10 15

Thr Asp Ala Glu Leu He Ala Lys Asn Asn Ser Glu Thr He Ala His

20 25 30

Phe Ser Thr Gly Asp Leu Leu Arg Ala Glu Ser Ala Lys Lys Thr Glu

35 40 45

Arg Gly Leu Leu He Glu Lys Phe Thr Ser Gin Gly Glu Leu Val Pro

50 55 60

Leu Glu He Val Val Glu Thr He Leu Ser Ala He Lys Ser Ser Ser 65 70 75 80

Lys Gly He He Leu He Asp Gly Tyr Pro Arg Ser Val Glu Gin Met

85 90 95

Gin Ala Leu Asp Lys Glu Leu Asn Ala Pro Asn Glu Val He Leu Lys

100 105 110

Ser Val He Glu Val Glu Val Ser Glu Asn Thr Ala Lys Glu Arg Val

115 120 125

Leu Gly Gin Phe 130

(2) INFORMATION FOR SEQ ID NO: 953: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 153 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 153

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 953:

Met His Tyr Ser Tyr Glu Ala Phe Leu Lys Asp Ser Leu Glu Leu Ala

1 5 10 15

Lys Gin Val Glu Arg Leu Cys Gly He Pro Glu Ala Leu Val Cys Val

20 25 30

Met Arg Gly Gly Met Thr Leu Val His Phe Leu Ser Leu His Trp Asn

35 40 45

Leu Arg Glu Val Tyr Gly He Asn Ala He Ser Tyr Asp Thr Thr Lys

50 55 60

Arg Gin Asn Ala Leu Lys He Glu Asn Thr Pro Thr He Lys Asp His 65 70 75 80

Leu Lys Thr He Leu Val Val Asp Glu He Val Asp Ser Gly Asn Ser

85 90 95

Leu Glu Ala Val Leu Lys Val Leu Gin Asp Lys His Pro Asp Lys Lys

100 105 110

Phe Tyr Ser Ala Ser Leu Phe Gin Lys Thr Ser Ala Lys Tyr Lys Ala

115 120 125

Asp Ala Phe Leu Lys Asp Ala Pro Glu Trp He Asp Phe Phe Trp Glu

130 135 140

Val Asp Leu Lys Asn Leu Lys Ser His 145 150

(2) INFORMATION FOR SEQ ID NO: 954:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 235 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . .235 ( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 954 :

Leu Ser Glu Pro He Asp Arg Phe Thr Arg H e Arg Trp Leu Phe Lys

1 5 10 15

Asn Asp Phe Glu Lys He Arg Gin Gin Arg Val Leu He Cys Gly Val

20 25 30

Gly Gly Val Gly Gly Phe Ala Leu Asp Ser Leu Tyr Arg Val Gly He

35 40 45

Gly Gin He Thr He He Asp Lys Asp Met Phe Asp Val Thr Asn Gin

50 55 60

Asn Arg Gin He Gly Ser Glu Arg He Gly Glu Ser Lys Val Leu Val 65 70 75 80

Leu Gin Asp Leu Tyr Lys Gly He Gin Ala Leu Asn Cys Arg He Asp

85 90 95

Glu Ala Phe Leu Asn Ser Phe Asn Phe Arg Asp Tyr Asp Tyr He Leu

100 105 110

Asp Cys Met Asp Asp Leu Pro He Lys Thr Ser Leu Ala He Lys Cys

115 120 125

Gin Asn Phe Ala Tyr Gly Lys Phe He Ser Ser Met Gly Ser Ala Lys

130 135 140

Arg Leu Asn Pro Lys His He Gin Val Gly Ser Val Trp Glu Ser Tyr 145 150 155 160

Gly Asp Lys Phe Gly Arg Lys Phe Arg Asp Phe Leu Lys Lys Arg Arg

165 170 175

Phe Lys Gly Asp Phe Lys Val Val Phe Ser Pro Glu Val Pro His Cys

180 185 190

He Glu Leu Gly Ser Phe Asn Ala Val Thr Ala Ser Phe Gly Leu Gin

195 200 205

He Ala Ser Glu Val Val Gin Asp He He Lys Asn Glu Arg Gin Trp

210 215 220

Asn Glu Arg Leu Arg Arg Arg He Gly Arg Phe 225 230 235

(2) INFORMATION FOR SEQ ID NO: 955:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 439 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL : YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...439

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 955 :

Met Gin Val Lys Glu Asn Lys Gin Leu Cys Leu He Ser Leu Gly Cys

1 5 10 15

Ser Lys Asn Leu Val Asp Ser Glu Val Met Leu Gly Lys Leu Tyr Asn 20 25 30

Tyr Thr Leu Thr Asn Asp Ala Lys Lys Ala Asp Val He Leu He Asn

35 40 45

Thr Cys Gly Phe He Glu Ser Ala Lys Gin Glu Ser He Gin Thr He

50 55 60

Leu Asn Ala Ala Lys Asp Lys Lys Glu Gly Ala He Leu He Ala Ser 65 70 75 80

Gly Cys Leu Ser Glu Arg Tyr Lys Asp Glu He Lys Glu Leu He Pro

85 90 95

Glu Val Asp He Phe Thr Gly Val Gly Asp Tyr Asp Lys He Asp He

100 105 110

Leu He Ala Lys Lys Gin Asn Gin Phe Ser Glu Gin Val Phe Leu Ser

115 120 125

Glu His Tyr Asn Ala Arg He He Thr Gly Ser Ser Val His Ala Tyr

130 135 140

Val Lys He Ser Glu Gly Cys Asn Gin Lys Cys Ser Phe Cys Ala He 145 150 155 160

Pro Ser Phe Lys Gly Lys Leu Gin Ser Arg Glu Leu Asp Ser He Leu

165 170 175

Lys Glu Val Glu Asp Leu Ala Leu Lys Gly Tyr Lys Asp Met Thr Phe

180 185 190

He Ala Gin Asp Ser Ser Ser Phe Leu Tyr Asp Lys Gly Gin Lys Asp

195 200 205

Gly Leu He Gin Leu He Arg Ala He Asp Lys Gin Gin Ala Leu Lys

210 215 220

Ser Ala Arg He Leu Tyr Leu Tyr Pro Ser Ser Thr Thr Leu Glu Leu 225 230 235 240

He Gly Ala He Glu Asp Ser Pro He Phe Gin Asn Tyr Phe Asp Met

245 250 255

Pro He Gin His He Ser Asp Ser Met Leu Lys Lys Met Arg Arg Asn

260 265 270

Ser Ser Gin Ala His His Leu Lys Leu Leu Asn Ala Met Lys Gin Val

275 280 285

Lys Glu Ser Phe He Arg Ser Thr He He Val Gly His Pro Glu Glu

290 295 300

Asn Glu Ser Glu Phe Glu Glu Leu Ser Ala Phe Leu Asp Glu Phe Arg 305 310 315 320

Phe Asp Arg Leu Asn He Phe Ala Phe Ser Ala Glu Glu Asn Thr His

325 330 335

Ala Tyr Ser Leu Glu Lys Val Pro Lys Lys He He Asn Ala Arg He

340 345 350

Lys Ala Leu Asn Lys He Ala Leu Lys His Gin Asn His Ser Phe Lys

355 360 365

Ala Leu Leu Asn Lys Pro He Lys Ala Leu Val Glu His Lys Glu Gly

370 375 380

Glu Tyr Phe Tyr Lys Ala Arg Asp Leu Arg Trp Ala Pro Glu Val Asp 385 390 395 400

Gly Glu He Leu He Asn Asp Ser Glu Leu Thr Thr Pro Leu Lys Pro

405 410 415

Gly His Tyr Thr He Val Pro Ser Ala Phe Lys Asp Asn He Leu Leu

420 425 430

Ala Lys Val Leu Ser Pro Phe 435

(2) INFORMATION FOR SEQ ID NO: 956:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 667 ammo acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(m) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...667

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 956:

Lys Lys Pro Phe Tyr Ser Leu Ser Leu Ala Ser Ser Leu Leu Asn Ala

1 5 10 15

Glu Asp Asn Gly Phe Phe He Ser Ala Gly Tyr Gin He Gly Glu Ala

20 25 30

Ala Gin Met Val Lys Asn Thr Gly Glu Leu Lys Lys Leu Ser Asp Thr

35 40 45

Tyr Glu Asn Leu Ser Asn Leu Leu Thr Asn Phe Asn Asn Leu Asn Gin

50 55 60

Ala Val Thr Asn Ala Ser Ser Pro Ser Glu He Asn Ala Ala He Asp 65 70 75 80

Asn Leu Lys Ala Asn Thr Gin Gly Leu He Gly Glu Lys Thr Asn Ser

85 90 95

Pro Ala Tyr Gin Ala Val Tyr Leu Ala Leu Asn Ala Ala Val Gly Leu

100 105 110

Trp Asn Val He Ala Tyr Asn Val Gin Cys Gly Pro Gly Asn Ser Gly

115 120 125

Gin Gin Ser Val Thr Phe Glu Gly Gin Pro Gly His Asn Ser Ser Ser

130 135 140

He Asn Cys Asn Leu Thr Gly Tyr Asn Asn Gly Val Ser Gly Pro Leu 145 150 155 160

Ser He Glu Asn Phe Lys Lys Leu Asn Gin Ala Tyr Gin Thr He Gin

165 170 175

Gin Ala Leu Lys Gin Asp Ser Gly Phe Pro Val Leu Asp Ser Ala Gly

180 185 190

Lys Gin Val Thr He Thr He Thr Thr Gin Thr Asn Gly Ala Asn Lys

195 200 205

Ser Glu Thr Thr Thr Thr Thr Thr Thr Thr Asn Asp Ala Gin Thr Leu

210 215 220

Leu Gin Glu Ala Ser Lys Met He Ser Val Leu Thr Thr Asn Cys Pro 225 230 235 240

Trp Val Asn His Asn Gin Gly Gin Asn Gly Gly Ala Pro Trp Gly Leu

245 250 255

Asp Thr Ala Gly Asn Val Cys Gin Val Phe Ala Thr Glu Phe Ser Ala

260 265 270

Val Thr Ser Met He Lys Asn Ala Gin Glu He Val Thr Gin Ala Gin

275 280 285

Ser Leu Asn Gin Gin Asn Asn Gin Asn Ala Pro Gin Asp Phe Asn Pro

290 295 300

Tyr Thr Ser Ala Asp Arg Ala Phe Ala Gin Asn Met Leu Asn His Ala 305 310 315 320 Gin Ala Gin Ala Lys He Leu Glu Leu Ala Asp Gin Met Lys Lys Asp

325 330 335

Leu Asn Thr He Pro Ser Gin Phe He Thr Asn Tyr Leu Ala Ala Cys

340 345 350

His Asn Gly Gly Gly Thr Leu Pro Asp Ala Gly Val Thr Asn Asn Thr

355 360 365

Trp Gly Ala Gly Cys Ala Tyr Val Glu Glu Thr He Thr Ala Leu Asn

370 375 380

Asn Ser Leu Ala His Phe Gly Thr Gin Ala Glu Gin He Lys Gin Ser 385 390 395 400

Glu Leu Leu Ala Arg Thr He Leu Asp Phe Arg Gly Ser Leu Ser Asn

405 410 415

Leu Asn Asn Thr Tyr Asn Ser He Thr Thr Thr Ala Ser Asn Thr Pro * 420 425 430

Asn Ser Pro Phe Leu Lys Asn Leu He Ser Gin Ser Thr Asn Pro Asn

435 440 445

Asn Pro Gly Gly Leu Gin Ala Val Tyr Gin Val Asn Gin Ser Ala Tyr

450 455 460

Ser Gin Leu Leu Ser Ala Thr Gin Glu Leu Gly His Asn Pro Phe Arg 465 470 475 480

Arg Val Gly Leu He Ser Ser Gin Thr Asn Asn Gly Ala Met Asn Gly

485 490 495

He Gly Val Gin Val Gly Tyr Lys Gin Phe Phe Gly Glu Lys Arg Arg

500 505 510

Trp Gly Leu Arg Tyr Tyr Gly Phe Phe Asp Tyr Asn His Ala Tyr He

515 520 525

Lys Ser Ser Phe Phe Asn Ser Ala Ser Asp Val Phe Thr Tyr Gly Val

530 535 540

Gly Thr Asp Val Leu Tyr Asn Phe He Asn Asp Lys Thr Thr Lys Asn 545 550 555 560

Ser Lys He Ser Phe Gly Val Phe Gly Gly He Ala Leu Ala Gly Thr

565 570 575

Ser Trp Leu Asn Ser Gin Tyr Val Asn Leu Ala Thr Phe Asn Asn Phe

580 585 590

Tyr Ser Ala Lys Met Asn Val Ala Asn Phe Gin Phe Leu Phe Asn Leu

595 600 605

Gly Leu Arg Met Asn Leu Ala Lys Asn Lys Lys Lys Ala Ser Asp His

610 615 620

Ala Ala Gin His Gly Val Glu Leu Gly Val Lys He Pro Thr He Asn 625 630 635 640

Thr Asn Tyr Tyr Ser Leu Leu Gly Thr Gin Leu Gin Tyr Arg Arg Leu

645 650 655

Tyr Ser Val Tyr Leu Asn Tyr Val Phe Ala Tyr 660 665

(2) INFORMATION FOR SEQ ID NO: 957:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 87 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE: (A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...87

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 957:

Met Phe He Leu Phe Lys Phe Gly Arg Val Leu Gly Lys Ala Tyr Ser

1 5 10 15

Leu Tyr Leu Tyr He Tyr Glu Ser Leu He Cys Gin Ala Phe Gly Leu

20 25 30

Ser Leu Ser Cys Asn Asn Ser Met Leu Phe Ser Thr Phe Leu He Asn

35 40 45

Leu Pro Leu Pro His Asn Glu Ser Leu Cys Cys Cys Arg Asp He Leu

50 55 60

Ala Tyr Ser Asn Ser Ser Ser Leu Lys Thr Tyr Ser Leu Glu Ser Asn 65 70 75 80

Phe Ser Phe Asn Ser Leu Phe 85

(2) INFORMATION FOR SEQ ID NO: 958:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 134 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...134

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 958:

Met Phe Met Ala Ser He Arg Thr Leu Thr His Met Thr Asn Ala Asp

1 5 10 15

Gly Thr He Thr Cys Gly Asp Thr Thr Pro Ala Ser Cys Asn Val Gly

20 25 30

He Asn Pro Asn Ser Val Tyr Thr Thr Gly Lys Leu Asn Ala Lys Val

35 40 45

Asn His Thr He Phe Gin Phe Leu Val Asn Val Gly He Arg Thr Asn

50 55 60

He Phe Glu His His Gly He Glu Phe Gly He Lys He Pro Thr Leu 65 70 75 80

Pro Asn Tyr Phe Phe Lys Gly Ser Thr Thr He Arg Ala Lys Lys Gin

85 90 95

Gly Pro Leu Glu Asn Gly Asn Pro Thr Thr He Thr Gly Ala Glu Thr

100 105 110

Asn Phe Ser Leu Thr Gin Thr Leu Arg Arg Gin Tyr Ser Met Tyr Leu 115 120 125 Arg Tyr Val Tyr Thr Phe 130

(2) INFORMATION FOR SEQ ID NO: 959:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 278 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...278

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 959:

Leu Asn Lys Leu Leu Lys Lys Gly Phe Leu Ala Phe Phe Leu Ser Val

1 5 10 15

Tyr Leu Arg Ala Asp Asp Leu Val Thr Tyr Thr He Ala Lys Glu Glu

20 25 30

Asp Leu Gly Tyr Gin Arg Phe Leu Ala Lys Lys Cys Leu Arg Gly Lys

35 40 45

Thr His Pro Pro Cys Phe Thr Ala Ser Lys Lys Pro Lys Arg Lys Pro

50 55 60

Phe Asn He Asp Lys Ser Ser His Tyr Tyr Gly Thr Ser Val Val Gin 65 70 75 80

Met Ser Trp Leu Gin Ser Arg Glu Lys Phe Glu Asn His Ser Lys Tyr

85 90 95

Arg Asn He Pro Phe Ala Glu Val Ser Leu He Tyr Gly Tyr Lys Gin

100 105 110

Phe Phe Pro Lys Lys Glu His Tyr Gly Phe Arg Phe Tyr Val Ser Leu

115 120 125

Asp Tyr Ala Tyr Gly Phe Phe Leu Lys Asn Lys Gly Ala Leu Gly Asp

130 135 140

Ser Leu Arg Ala Ser Ser Gin He Pro Lys Ser Tyr Arg Glu Lys Leu 145 150 155 160

Gin Arg Lys Glu Thr Phe He Asn Ala He Phe Tyr Gly Val Gly Ala

165 170 175

Asp Phe Leu Tyr Lys Arg Ala Phe Gly Thr Leu He Leu Gly Val Asn

180 185 190

Phe Val Gly Glu Thr Trp Phe Tyr Glu Thr Lys He Phe Lys Gin Trp

195 200 205

Ala Lys Asp Ser Leu Asn Thr Tyr Arg Pro Asn Met Phe Gin Val Met

210 215 220

Leu Asn Val Gly Tyr Arg Tyr Arg Phe Ser Arg Tyr Lys Asn Trp Ala 225 230 235 240

He Glu Phe Gly Ala Arg He Pro Phe Leu He Asn Asp Tyr Phe Lys

245 250 255

Thr Pro Leu Tyr Thr Leu His Phe Lys Arg Asn He Ser Val Tyr Leu 260 265 270 Thr Ser Thr Tyr Asp Phe 275

(2) INFORMATION FOR SEQ ID NO: 960:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 499 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 499

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 960:

Met Lys Leu Lys Lys Arg Lys Val Ala Ala Thr Leu Leu Lys Arg Leu

1 5 10 15

Thr Leu Pro Leu Leu Phe Thr Thr Gly Ser Leu Gly Ala Val Thr Tyr

20 25 30

Glu Val His Gly Asp Phe He Asn Phe Ser Lys Val Gly Phe Asn Arg

35 40 45

Ser Pro He Asn Pro Val Lys Gly He Tyr Pro Thr Glu Thr Phe Val

50 55 60

Asn Leu Thr Gly Lys Leu Glu Gly Ser Val His Leu Gly Arg Gly Trp 65 70 75 80

Thr Val Asn Val Gly Gly Val Leu Gly Gly Gin Val Tyr Asp Asn Thr

85 90 95

Arg Tyr Asp Arg Trp Ala Lys Asp Phe Thr Pro Pro Ser Tyr Trp Asp

100 105 110

Lys Thr Ser Cys Gly Thr Asp Ser Leu Ser Leu Cys Met Asn Ala Thr

115 120 125

Lys Met Trp Gin Gin Gin Gly Pro Gly Gly He He Asp Pro Arg Gly

130 135 140

He Gly Tyr Met Tyr Met Gly Glu Trp Asn Gly Leu Phe Pro Asn Tyr 145 150 155 160

Tyr Pro Ala Asn Ala Tyr Leu Pro Gly His Ser Arg Arg Tyr Glu Val

165 170 175

Tyr Lys Ala Asn Leu Thr Tyr Asp Ser Asp Arg Val His Met Val Met

180 185 190

Gly Arg Phe Asp Val Thr Glu Gin Glu Gin Met Asp Trp He Tyr Gin

195 200 205

Leu Phe Gin Gly Phe Tyr Gly Thr Phe Lys Leu Thr Lys Asn Met Lys

210 215 220

Phe Leu Leu Phe Ser Ser Trp Gly Arg Gly He Ala Asp Gly Gin Trp 225 230 235 240

Leu Phe Pro He Tyr Arg Glu Lys Pro Trp Gly He His Lys Ala Gly

245 250 255

He He Tyr Arg Pro Thr Lys Asn Leu Met He His Pro Tyr Val Tyr 260 265 270 Leu He Pro Met Val Gly Thr Leu Pro Gly Ala Lys He Glu Tyr Asp

275 280 285

Thr Asn Pro Glu Phe Ser Gly Arg Gly He Arg Asn Lys Thr Thr Phe

290 295 300

Tyr Val Leu Tyr Asp Tyr Arg Trp Asn Asn Ala Glu Tyr Gly Arg Tyr 305 310 315 320

Ala Pro Ala Arg Tyr Asn Thr Trp Asp Pro Phe Leu Asp Asn Gly Lys

325 330 335

Trp Arg Gly Leu Gin Gly Pro Gly Gly Ala Thr Leu Tyr Leu His His

340 345 350

His He Asp He Asn Asn Tyr Phe Val Val Gly Gly Ala Tyr Leu Asn

355 360 365

He Gly Asn Pro Asn Met Asn Leu Gly Thr Trp Gly Asn Pro Val Ala

370 375 380

Leu Asp Gly He Glu Gin Trp Val Gly Gly He Tyr Ser Leu Gly Phe 385 390 395 400

Ala Gly He Asp Asn He Thr Asp Ala Asp Ala Phe Thr Glu Tyr Val

405 410 415

Lys Gly Gly Gly Lys His Gly Lys Phe Ser Trp Ser Val Tyr Gin Arg

420 425 430

Phe Thr Thr Ala Pro Arg Ala Leu Glu Tyr Gly He Gly Met Tyr Leu

435 440 445

Asp Tyr Gin Phe Ser Lys His Val Lys Ala Gly Leu Lys Leu Val Trp

450 455 460

Leu Glu Phe Gin He Arg Ala Gly Tyr Asn Pro Gly Thr Gly Phe Leu 465 470 475 480

Gly Pro Asn Gly Gin Pro Leu Asn Leu Asn Asn Gly Leu Phe Glu Ser

485 490 495

Ser Ala Phe

(2) INFORMATION FOR SEQ ID NO: 961:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 68 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...68

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 961 :

Leu Lys Glu Lys Phe Asp Phe Phe Lys Gly Lys Asn Phe Lys He Val

1 5 10 15

Tyr Cys He Gly Glu Asp Leu Thr Thr Arg Glu Lys Gly Phe Arg Ala

20 25 30

Val Lys Glu Phe Leu Ser Glu Gin Leu Glu Asn He Asp Leu Asn Tyr 35 40 45 Ser Asn Leu He Val Ala Tyr Glu Pro He Trp Ala He Gly Thr Lys

50 55 60

Lys Ala Arg Phe 65

(2) INFORMATION FOR SEQ ID NO: 962:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 263 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...263

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 962 :

Met Ser Lys Ser Ala He Phe Val Leu Ser Gly Phe Leu Ala Phe Leu

1 5 10 15

Leu Tyr Ala Leu Leu Leu Tyr Gly Leu Leu Leu Glu Arg His Asn Lys

20 25 30

Glu Ala Glu Lys He Leu Leu Asp Leu Asn Lys Lys Asp Glu Gin Ala

35 40 45

He Asp Leu Asn Leu Glu Asp Leu Pro Ser Glu Lys Lys Asn Glu Lys

50 55 60

He Glu Lys Val Thr Glu Lys Gin Gly Asp Phe Leu Glu Pro Lys Glu 65 70 75 80

Glu Pro Lys Glu Glu Pro Glu Glu Ser Leu Glu Asp He Phe Ser Ser

85 90 95

Leu Asn Asp Phe Gin Glu Lys Thr Asp Lys Asn Ala Gin Lys Asp Glu

100 105 110

Gin Lys Asn Glu Gin Glu Glu Gin Arg Arg Leu Arg Glu Gin Gin Arg

115 120 125

Leu Lys Gin Asn Gin Glu Asn Gin Glu Met Leu Lys Gly Leu Gin Gin

130 135 140

Asn Leu Asn Gin Phe Thr Gin Lys Leu Glu Ser Val Lys Asn Lys Thr 145 150 155 160

Leu Asp Leu Gin He Pro Lys Gin Asp Gly Val Asp Glu Lys Ala Tyr

165 170 175

Gin Glu Trp Tyr Ala Gin He Tyr Gin He Leu Tyr Lys Gly Trp Arg

180 185 190

Gly Val Phe Tyr His Lys Ala Ser Val Ser Val Leu He Met He Thr

195 200 205

Lys Asp Gly Glu Phe Asp Tyr Thr He Leu Ser Tyr Ser Asp Phe Lys

210 215 220

Asp Tyr Asn Lys Ser Val Met Thr Leu Leu Asp Asp Leu Lys Lys Val 225 230 235 240

Asp Phe Pro Pro Tyr Pro Gly Gly Asn Met He Ser He Lys Val Asn 245 250 255 Phe Thr Thr Lys Glu Glu Gin 260

(2) INFORMATION FOR SEQ ID NO: 963:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 785 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...785

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 963 :

Met Glu Gin Pro Val He Lys Glu Gly Thr Leu Ala Leu He Asp Thr

1 5 10 15

Phe Ala Tyr Leu Phe Arg Ser Tyr Tyr Met Ser Ala Lys Asn Lys Pro

20 25 30

Leu Thr Asn Asp Lys Gly Phe Pro Thr Gly Leu Leu Thr Gly Leu Val

35 40 45

Gly Met Val Lys Lys Phe Tyr Lys Asp Arg Lys Asn Met Pro Phe He

50 55 60

Val Phe Ala Leu Glu Ser Gin Thr Lys Thr Lys Arg Ala Glu Lys Leu 65 70 75 80

Gly Glu Tyr Lys Gin Asn Arg Lys Asp Ala Pro Lys Glu Met Leu Leu

85 90 95

Gin He Pro He Ala Leu Glu Trp Leu Gin Lys Met Gly Phe Thr Cys

100 105 110

Val Glu Val Gly Gly Phe Glu Ala Asp Asp Val He Ala Ser Leu Ala

115 120 125

Thr Leu Ser Pro Tyr Lys Thr Arg He Tyr Ser Lys Asp Lys Asp Phe

130 135 140

Asn Gin Leu Leu Ser Asp Lys He Ala Leu Phe Asp Gly Lys Thr Glu 145 150 155 160

Phe Leu Ala Lys Asp Cys Val Glu Lys Tyr Gly He Leu Pro Ser Gin

165 170 175

Phe Thr Asp Tyr Gin Gly He Val Gly Asp Ser Ser Asp Asn Tyr Lys

180 185 190

Gly Val Lys Gly He Gly Ser Lys Asn Ala Lys Glu Leu Leu Gin Arg

195 200 205

Leu Gly Ser Leu Glu Lys He Tyr Glu Asn Leu Asp Leu Ala Lys Asn

210 215 220

Leu Leu Ser Pro Lys Met Tyr Gin Ala Leu He Gin Asp Lys Gly Ser 225 230 235 240

Ala Phe Leu Ser Lys Glu Leu Ala Thr Leu Glu Arg Gly Cys He Lys

245 250 255

Glu Phe Asp Phe Leu Ser Cys Ala Phe Pro Ser Glu Asn Pro Leu Leu 260 265 270 Lys He Lys Asp Glu Leu Lys Glu Tyr Gly Phe He Ser Thr Leu Arg

275 280 285

Asp Leu Glu Asn Ser Pro Phe He Val Glu Asn Val Pro He Leu Asn

290 295 300

Ser Thr Pro He Leu Asp Asn Thr Pro Ala Leu Asp Asn Ala Pro Lys 305 310 315 320

Lys Ser Arg Met He Val Leu Glu Ser Ala Glu Pro Leu Ser Met Phe

325 330 335

Leu Glu Lys Leu Glu Asn Pro Asn Ala Arg Val Phe Met Arg Leu Val

340 345 350

Leu Asp Lys Asp Lys Lys He Leu Ala Leu Ala Phe Leu Leu Gin Asp

355 360 365

Gin Gly Tyr Phe Leu Pro Leu Glu Glu Ala Leu Phe Ser Pro Phe Ser

370 375 380

Leu Glu Phe Leu Gin Asn Ala Phe Ser Gin Met Leu Gin His Ala Cys 385 390 395 400

He He Gly His Asp Leu Lys Pro Leu Leu Ser Phe Leu Lys Ala Lys

405 410 415

Tyr Gin Val Pro Leu Glu Asn He Arg He Gin Asp Thr Gin He Leu

420 425 430

Ala Phe Leu Lys Asn Pro Glu Lys Val Gly Phe Asp Glu Val Leu Lys

435 440 445

Glu Tyr Leu Lys Glu Asp Leu He Pro His Glu Lys He Lys Asp Phe

450 455 460

Lys Thr Lys Ser Lys Ala Glu Lys Ser Glu Leu Leu Ser Met Glu Leu 465 470 475 480

Asn Ala Leu Lys Arg Leu Cys Glu Tyr Phe Glu Lys Gly Gly Leu Glu

485 490 495

Glu Asp Leu Leu Thr Leu Ala Arg Asp He Glu Thr Pro Phe Val Lys

500 505 510

Val Leu Met Gly Met Glu Phe Gin Gly Phe Lys He Asp Ala Pro Tyr

515 520 525

Phe Lys Arg Leu Glu Gin Glu Phe Lys Asn Glu Leu Asn Val Leu Glu

530 535 540

Arg Gin He Leu Asp Leu He Gly Val Asp Phe Asn Leu Asn Ser Pro 545 550 555 560

Lys Gin Leu Gly Glu Val Leu Tyr Asp Lys Leu Gly Leu Pro Lys Asn

565 570 575

Lys Ser His Ser Thr Asp Glu Lys Asn Leu Leu Lys He Leu Asp Lys

580 585 590

His Pro Ser He Pro Leu He Leu Glu Tyr Arg Glu Leu Asn Lys Leu

595 600 605

Phe Asn Thr Tyr Thr Thr Pro Leu Leu Arg Leu Lys Asp Lys Asp Asp

610 615 620

Lys He His Thr Thr Phe He Gin Thr Gly Thr Ala Thr Gly Arg Leu 625 630 635 640

Ser Ser His Ser Pro Asn Leu Gin Asn He Pro Val Arg Ser Pro Lys

645 650 655

Gly Leu Leu He Arg Lys Gly Phe He Ala Ser Ser Lys Glu Tyr Cys

660 665 670

Leu Leu Gly Val Asp Tyr Ser Gin He Glu Leu Arg Leu Leu Ala His

675 680 685

Phe Ser Gin Asp Lys Asp Leu Met Glu Ala Phe Leu Lys Gly Arg Asp

690 695 700

He His Leu Glu Thr Ser Lys Ala Leu Phe Gly Glu Asp Leu Ala Lys 705 710 715 720

Glu Lys Arg Ser He Ala Lys Ser He Asn Phe Gly Leu Val Tyr Gly 725 730 735

Met Gly Ser Lys Lys Leu Ser Glu Thr Leu Ser He Pro Leu Ser Glu

740 745 750

Ala Lys Ser Tyr He Glu Ala Tyr Phe Lys Arg Phe Pro Ser He Lys

755 760 765

Asp Tyr Leu Asn Gly Met Arg Glu Glu He Leu Lys Thr Ser Lys Ala

770 775 780

Phe 785

(2) INFORMATION FOR SEQ ID NO: 964:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 55 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...55

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 964 :

Val Ser Glu Ser Glu Lys Gin Glu He Glu Asn Lys He Glu Glu Arg

1 5 10 15

Lys Arg Ala Lys Glu Gin Lys Asp Phe Leu Lys Ala Asp Ser He Arg

20 25 30

Glu Glu Leu Leu Gin Gin Lys He Ala Leu Met Asp Thr Pro Gin Gly

35 40 45

Thr He Trp Glu Lys Leu Phe 50 55

(2) INFORMATION FOR SEQ ID NO: 965:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 571 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME / KEY : mi scjeature

( B ) LOCATION 1 . . . 571 ( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 965 :

Leu Pro Ser Val Gin He Trp Gly Ser Tyr Thr Asn Ser Phe Lys Gin

1 5 10 15

Thr Phe Ser Ala Ser Asn Ser Asn Leu Val He Gly Tyr Asn Ala Thr

20 25 30

Trp Thr Asp Pro Asn Val Ser Ser Ser Asp Thr Val Ala Phe Gly Asp

35 40 45

Pro Ser Gly Ser Ala Leu Asn Gly His Cys Gly Pro Trp Pro Tyr Tyr

50 55 60

Gin Cys Thr Gly Thr Thr Asn Gly Thr Tyr Ser Ala Tyr His Val Tyr 65 70 75 80

He Thr Ala Asn Leu Arg Ser Gly Asn Arg He Gly Thr Gly Gly Ala

85 90 95

Ala Asn Leu He Phe Asn Gly Val Asp Ser He Asn He Ala Asn Ala

100 105 110

Thr He Thr Gin His Asn Ala Gly Ala Tyr Ser Ser Ser Met Thr Phe

115 120 125

Ser Thr Gin Asn Met Asp Asn Ser Gin Asn Leu Asn Gly Leu Asn Ser

130 135 140

Asn Gly Lys Leu Leu Val Tyr Gly Thr Thr Phe Thr Asn Gin Ala Lys 145 150 155 160

Asp Gly Lys Phe He Phe Asn Ala Gly Gin Ala Thr Phe Glu Asn Thr

165 170 175

Asn Phe Asn Gly Gly Ser Tyr Gin Phe Ser Gly Asp Ser Leu Asn Phe

180 185 190

Ser Asn Asn Asn Gin Phe Asn Ser Gly Ser Phe Glu He Gly Ala Lys

195 200 205

Asn Thr He Phe Asn Asn Ala Asn Phe Asn Asn Ser Thr Ser Phe Asn

210 215 220

Phe Asn Asn Ser Ser Ala Thr Thr Ser Phe Val Gly Asp Phe Thr Asn 225 230 235 240

Ala Asn Ser Asn Leu Gin He Ala Gly Asn Ala Val Phe Gly Asn Ser

245 250 255

Thr Asn Gly Ser Gin Asn Thr Ala Asn Phe Asn Asn Thr Gly Ser Val

260 265 270

Asn He Ala Gly Asn Ala Thr Phe Asp Asn Val Val Phe Asn Ser Pro

275 280 285

Thr Asn Thr Ser Val Lys Gly Lys Val Thr Leu Asn Asn He Thr Leu

290 295 300

Lys Asn Leu Asn Ala Pro Leu Ser Phe Gly Asp Gly Thr He Val Phe 305 310 315 320

Ser Ala His Ser Val He Asn He Gly Glu Ala He Thr Asn Gly Asn

325 330 335

Pro He Thr Leu Val Ser Ser Ser Lys Ala He Glu Tyr Asn Asp Ala

340 345 350

Phe Ser Lys Asn Leu Trp Gin Leu He Asn Tyr Gin Gly His Gly Ala

355 360 365

Ser Ser Glu Lys Leu Val Ser Ser Ala Gly Asn Gly Val Tyr Asp Val

370 375 380

Val Tyr Ser Leu Asn Asn Gin Thr Tyr Asn Phe Gin Glu Val Phe Ser 385 390 395 400

Pro Asn Ser He Ser He Arg Arg Leu Gly Val Gly Met Val Phe Asp

405 410 415

Tyr Val Asp Met Glu Lys Ser Asp Arg Leu Tyr Tyr Gin Asn Ala Leu

420 425 430

Gly Phe Met Thr Tyr Met Pro Asn Ser Tyr Asn Asn Asn Leu Gly Asn 435 440 445

Leu Asn Asn Thr He Tyr Tyr Tyr Asp Asn Ser He Asp Phe Tyr Ala

450 455 460

Ser Gly Lys Thr Leu Phe Thr Lys Ala Glu Phe Ser Gin Thr Phe Thr 465 470 475 480

Gly Gin Asn Ser Ala He Val Phe Gly Ala Lys Asn He Trp Thr Ser

485 490 495

Val Ser Asp Ala Pro Gin Ser Asn Val He He Arg Phe Gly Asp Asn

500 505 510

Lys Gly Ala Gly Ser Asn Asp Ala Ser Gly His Cys Trp Asn Leu Gin

515 520 525

Cys He Gly Phe He Thr Gly His Tyr Glu Ala Gin Lys He Tyr He

530 535 540

Thr Gly Ser He Glu Ser Gly Asn Arg He Ser Ser Gly Gly Ala Arg 545 550 555 560

Ala Leu He Leu Thr Gly Phe Lys Ala Phe Phe 565 570

(2) INFORMATION FOR SEQ ID NO: 966:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 368 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...368

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 966 :

Met Val Val Leu Gly Ser Thr Gly Ser He Gly Lys Asn Ala Leu Lys

1 5 10 15

He Ala Lys Lys Phe Gly Val Lys He Glu Ala Leu Ser Cys Gly Lys

20 25 30

Asn He Ala Leu He Asn Glu Gin He Lys Val Phe Lys Pro Lys Lys

35 40 45

Val Ala He Leu Asp Pro Asn Asp Leu Asn Asn Leu Glu Pro Leu Gly

50 55 60

Ala Glu Val Phe Val Gly Leu Asp Gly He Asp Ala Met He Glu Glu 65 70 75 80

Cys Val Ser Asn Leu Val He Asn Ala He Val Gly Val Ala Gly Leu

85 90 95

Lys Ala Ser Phe Lys Ser Leu Gin Arg Asn Lys Lys Leu Ala Leu Ala

100 105 110

Asn Lys Glu Ser Leu Val Ser Ala Gly His Leu Leu Asp He Ser Gin

115 120 125

He Thr Pro Val Asp Ser Glu His Phe Gly Leu Trp Ala Leu Leu Gin

130 135 140

Asn Lys Thr Leu Lys Pro Lys Ser Leu He He Ser Ala Ser Gly Gly 145 150 155 160

Ala Phe Arg Asp Thr Pro Leu Asp Leu He Ala He Gin Asn Ala Gin

165 170 175

Asn Ala Leu Lys His Pro Asn Trp Ser Met Gly Asp Lys He Thr He

180 185 190

Asp Ser Ala Ser Met Val Asn Lys Leu Phe Glu He Leu Glu Thr Tyr

195 200 205

Trp Leu Phe Gly Ala Ser Leu Lys He Asp Ala Leu He Glu Arg Ser

210 215 220

Ser He Val His Ala Leu Val Glu Phe Glu Asp Asn Ser Val He Ala 225 230 235 240

His Leu Ala Ser Ala Asp Met Gin Leu Pro He Ser Tyr Ala He Asn

245 250 255

Pro Lys Leu Ala Ser Leu Ser Ala Ser He Lys Pro Leu Asp Leu Tyr

260 265 270

Ala Leu Ser Ala He Lys Phe Glu Pro He Ser Val Glu Arg Tyr Thr

275 280 285

Leu Trp Arg Tyr Lys Asp Leu Leu Leu Glu Asn Pro Lys Leu Gly Val

290 295 300

Val Leu Asn Ala Ser Asn Glu Val Ala Met Lys Lys Phe Leu Asn Gin 305 310 315 320

Glu He Ala Phe Gly Gly Phe He Gin He He Ser Gin Ala Leu Glu

325 330 335

Leu Tyr Ala Lys Lys Ser Phe Lys Leu Ser Ser Leu Asp Glu Val Leu

340 345 350

Ala Leu Asp Lys Glu Val Arg Glu Arg Phe Gly Ser Val Ala Arg Val 355 360 365

(2) INFORMATION FOR SEQ ID NO: 967:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 86 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...86

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 967:

Met Lys Thr Thr Glu Asn Thr Asp Glu Thr His Leu Arg Glu Thr Lys

1 5 10 15

Asn Lys Leu Gly Arg Lys Pro Lys Ala Asp Ala Asn Lys Lys Thr Arg

20 25 30

Ala Val Ser Leu Tyr Phe Ser Asp Glu Gin Tyr Gin Lys Leu Glu Lys

35 40 45

Met Ala Asn Glu Glu Glu Glu Ser Val Gly Ser Tyr He Lys Arg Tyr

50 55 60

He Leu Lys Ala Leu Arg Lys He Glu Gin Gly Gly Gly Phe He Ala 65 70 75 80

Phe Asn Leu Phe Leu He 85

(2) INFORMATION FOR SEQ ID NO: 968:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 803 ammo acids

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...803

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 968:

Leu Trp Leu Lys Ser Lys Phe Phe Leu Leu Met Gly Val Gly Leu Leu

1 5 10 15

Ser His Ser Leu Asn Ala Leu Ser Leu Thr Leu Thr Gin Gly Lys Glu

20 25 30

Glu Gly Glu Asp Phe Ser Val Leu Thr Leu Arg Asn Asp Lys Ala Phe

35 40 45

Ser Cys Ser Tyr Ala Asn Glu Lys Pro Pro Ser Gly He Glu Ala Ser

50 55 60

Leu Ser He He His Ala Lys Arg Pro He Glu Cys Val He Asp Ser 65 70 75 80

He Pro Lys Glu Gly Phe Thr Pro Leu Glu Asn Ala Phe Phe Asn He

85 90 95

Thr Tyr Ser Met Arg Gin Gin Gin Phe He Leu His He Lys Pro Lys

100 105 110

Val Met Arg Arg Leu Thr Leu Phe Ser Phe Asp Arg Asp Tyr Lys Lys

115 120 125

Ala He Pro Leu Phe Val Glu Asn Asp Ala Lys Ala Lys Met Trp Gin

130 135 140

He He Gly Tyr Asp Gin Lys He Pro Phe Leu Ser Glu Lys Asp Asn 145 150 155 160

Ala Gin Lys Gly Leu Asn Phe Pro He He He Lys Asp Ala Gin Thr

165 170 175

Pro He He Gin Glu Leu Asp Val Asn Asn Lys Pro Leu Leu Thr Thr

180 185 190

Lys Gly Tyr Asp Leu Asn Ala Tyr Leu Glu Ala Lys Lys Gin Met Asp

195 200 205

Ser Gin Ala Tyr Phe Asp Ala Leu Arg Thr He Ser Arg Ala Phe Lys

210 215 220

Asn Tyr Pro Gin Thr He Phe Lys Lys Asp Leu Tyr Leu Leu Glu He 225 230 235 240

He Ala Leu Gly Lys Leu Gly He Lys Lys Ser Leu Leu He Asp He

245 250 255

Gly Thr Gin Trp He Lys Asn Tyr Pro Thr Asp Pro Asn He Pro Glu 260 265 270

Ala Leu Tyr Tyr Val Ala Lys Ala Leu Asp Glu Asn Asn Asn Tyr Lys

275 280 285

Gin Ala Val Arg Tyr Tyr Lys Arg He Leu Leu Glu Tyr Lys Asn Ser

290 295 300

Arg Tyr Ala Pro Leu Ala Gin Met Arg Leu Ala He Glu Ala Ala Glu 305 310 315 320

Gly Ser Asp Leu Ser Asn Ala Asn Met Leu Phe Lys Glu Ala Phe Ser

325 330 335

Asn Ala Lys Asp Lys Glu Ser Ala Ser Glu He Ala Leu Asn Trp Ala

340 345 350

Glu Ala Glu He Asn Tyr Gin Asn Phe Asn Asn Ala Lys Tyr Leu He

355 360 365

Asp Lys Val Val Gin Ser Asn Pro Asp Tyr Leu Ser Met His Ser Glu

370 375 380

Leu Ala Leu Glu Leu Leu Lys Leu Leu Lys Lys Asn Gin Met Asn Glu 385 390 395 400

Ser Ala He Glu He Ala His Leu Leu Leu Asn Gin Asp Asp Asp Leu

405 410 415

Lys Ala Lys Glu Gin Ala Leu Tyr Asp Leu Gly Ala Leu Tyr Ala Arg

420 425 430

He Lys Asp Phe Lys Asn Ala His Leu Tyr Asn Leu Gin Tyr Leu Gin

435 440 445

Asp His Ala Glu Leu Glu Arg Ala Ser Val Val Arg Ala Arg Asp Glu

450 455 460

Lys Ala Leu Phe Ser Met Glu Gly Asn Thr Gin Glu Lys He Ala His 465 470 475 480

Tyr Asp Lys He He Gin Asn Phe Pro Asn Ser Asn Glu Ala Gin Lys

485 490 495

Ala Leu Glu Leu Lys Ala Gin Leu Leu Phe Asp Asn Lys His Tyr Ala

500 505 510

Glu Val Leu Gly Met Gin Lys Asn Leu Pro Lys Asp Ser Pro Leu He

515 520 525

Gin Lys Thr Leu Asn He Leu Ala Lys Thr Pro Leu Glu Asp His Arg

530 535 540

Cys Lys Glu Ala Leu Lys Tyr Leu Ser Gin He Thr Ala Phe Ala Phe 545 550 555 560

Asn Pro Gin Glu Glu He Gin Ala Phe Asp Cys Leu Tyr Phe Ala Ser

565 570 575

Leu Lys Glu Lys Ala Gin He He Ala Leu Asn Ala Leu Lys Ala Ala

580 585 590

Lys Thr Pro Ser Glu Lys Leu Thr Trp Leu Tyr Arg Leu Gly Arg Asn

595 600 605

Tyr Tyr Arg Leu Gly Asp Phe Lys Asn Ser Thr Leu Ala Ser Lys Asp

610 615 620

Ala Leu He Leu Ala Gin Ser Leu Asn Lys Lys Glu Phe Tyr Asp He 625 630 635 640

Ala Phe Val Leu Phe Ser Asp Tyr Met Gin Asn Asn Glu Lys Gly Leu

645 650 655

Ala Leu Asn Leu Tyr Ala Phe Leu Glu Lys His Phe Lys Asp Asp Lys

660 665 670

Arg Met Ala Leu Val Tyr Phe Lys Leu Leu Glu Asn Glu Lys Asp Pro

675 680 685

Lys Ser Val Lys He Tyr Ala Thr Ser Leu Leu Lys Leu Gin Asp Ala

690 695 700

Tyr Lys Asp Tyr Ser Tyr Thr Pro Phe Gly Glu Phe Ala Leu He Asp 705 710 715 720 Ala Tyr Arg Thr Thr Lys Asp Tyr Ser Lys Ala Leu Glu Thr Leu Asp

725 730 735

Lys Leu Leu Asn Arg Arg Leu Ser Leu Glu Asp His Gin Lys Ala Leu

740 745 750

Tyr Leu Gin Ser Ser Leu Leu Asp Leu Thr Asn Gin Lys Ala Lys Ser

755 760 765

Lys Ala Ser Leu Glu Lys Cys Val Gin Leu Lys Gin Lys Asp Gin Thr

770 775 780

Asn Ala Trp Gin Asn Leu Cys Glu Gin Gly Leu Asn Leu Phe Lys Asn 785 790 795 800

Lys Glu Ser

(2) INFORMATION FOR SEQ ID NO: 969:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 265 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A ) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 265

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 969 :

Met He Leu Arg Ala Ser Val Leu Ser Ala Leu Leu Leu Val Gly Leu

1 5 10 15

Gly Ala Ala Pro Lys His Ser Val Ser Ala Ser Asp Lys Arg Met Gin

20 25 30

Asp Asn Leu Val Ser Val He Glu Lys Gin Thr Asn Lys Lys Val Arg

35 40 45

He Leu Glu He Lys Pro Leu Lys Ser Ser Gin Asp Leu Lys Met Val

50 55 60

Val He Glu Asp Pro Asp Thr Lys Tyr Asn He Pro Leu Val Val Ser 65 70 75 80

Lys Asp Gly Asn Ser Val He Gly Leu Ser Asn He Phe Phe Ser Asn

85 90 95

Lys Ser Asp Asp Val Lys Leu Val Ala Glu Thr Asn Gin Lys He Gin

100 105 110

Ala Leu Asn Ala Thr Gin Gin Asn Ser Ala Lys Leu Asn Ala He Phe

115 120 125

Asn Glu He Pro Ala Asp Tyr Ala He Glu Leu Pro Ser Thr Asn Ala

130 135 140

Glu Asn Lys Asp Lys He Leu Tyr He Val Ser Asp Pro Met Cys Pro 145 150 155 160

His Cys Gin Lys Glu Leu Thr Lys Leu Arg Asp His Leu Lys Glu Asn

165 170 175

Thr Val Arg Met Val Val Val Gly Trp Leu Gly Val Asn Ser Ala Lys 180 185 190 Lys Ala Ala Leu He Gin Glu Glu Met Ala Lys Ala Arg Ala Arg Gly

195 200 205

Ala Ser Val Glu Asp Lys He Ser He Leu Glu Lys He Tyr Ser Thr

210 215 220

Gin Tyr Asp He Asn Ala Gin Lys Glu Pro Glu Asp Leu Arg Thr Lys 225 230 235 240

Val Glu Asn Thr Thr Lys Lys He Phe Glu Ser Gly Val He Lys Gly

245 250 255

Val Pro Phe Leu Tyr His Tyr Lys Ala 260 265

(2) INFORMATION FOR SEQ ID NO: 70:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 227 ammo acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(m) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A ) NAME / KEY : miscjeature

( B ) LOCATION 1 . . . 227

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 970 :

Leu Asp Phe Lys Ala He Glu His Gly Glu Glu Thr Leu Lys Asn Glu

1 5 10 15

Thr Leu Arg Ala Leu Ser Asp Phe Ala Lys Ser Ser Asp Thr His He

20 25 30

Val Ala Cys Ser He Glu Lys Asn Asn Lys Lys Leu Tyr Asp Ser Ala

35 40 45

Tyr He He Pro Pro Lys Gly Lys He Val Gly Lys His Arg Lys He

50 55 60

Tyr Leu Trp Gly Asp Glu Lys Ser Arg Phe Lys Arg Gly Lys Lys Tyr 65 70 75 80

Glu Val Phe Thr Leu Asp Phe Gly Asp Phe Ser Ala Lys Val Gly Leu

85 90 95

Gin He Cys Tyr Glu Thr Gly Phe Gly Val Gly Ala Asn Leu Leu Val

100 105 110

Leu Gin Gly Ala Glu Val Leu He Tyr Pro Ser Ala Phe Gly Lys Ala

115 120 125

Arg Ala Tyr Asn Trp Asp Leu Leu Ser Lys Ala Arg Ala Leu Glu Asn

130 135 140

Gly Cys Phe Val Cys Ala Cys Asn His Ser Gly Glu Glu Thr Asn Ala 145 150 155 160

Lys Leu Lys Gin Thr Leu Glu Phe Ala Gly Asp Ser Arg He He Ala

165 170 175

Pro Asn Gly Lys He He Ala Gin Ala Thr Lys Leu Asn Glu Val He

180 185 190

He Ala Glu Met Asp Leu Asn Glu Val Ala Leu Gin Arg Gin Lys He 195 200 205 Pro Tyr Leu Gin Asp Phe Asp Thr Lys Leu Thr Lys Lys Gly Phe Gly

210 215 220

Lys Leu Thr 225

(2) INFORMATION FOR SEQ ID NO: 971:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 293 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...293

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 971 :

Met Ala Lys Glu He Leu Val Ala Tyr Gly Val Asp He Asp Ala Val

1 5 10 15

Ala Gly Trp Leu Gly Ser Tyr Gly Gly Glu Asp Ser Pro Asp Asp He

20 25 30

Ser Arg Gly Leu Phe Ala Gly Glu Val Gly He Pro Arg Leu Leu Lys

35 40 45

Leu Phe Lys Lys Tyr His Leu Pro Ala Thr Trp Phe Ala Pro Gly His

50 55 60

Ser He Glu Thr Phe Pro Glu Pro Met Lys Met He Val Asp Ala Gly 65 70 75 80

His Glu Val Gly Ala His Gly Tyr Ser His Glu Asn Pro He Ala Met

85 90 95

Thr Ala Lys Gin Glu Glu Asp Val Leu Leu Lys Ser Val Glu Leu He

100 105 110

Lys Asp Leu Thr Gly Lys Ala Pro Thr Gly Tyr Val Ala Pro Trp Trp

115 120 125

Glu Phe Ser Asn He Thr Asn Glu Leu Leu Leu Lys His Gly Phe Lys

130 135 140

Tyr Asp His Ser Leu Met His Asn Asp Phe Thr Pro Tyr Phe Val Arg 145 150 155 160

Val Gly Asp Ser Trp Ser Lys He Asp Tyr Ser Leu Glu Ala Lys Asp

165 170 175

Trp Met Lys Pro Leu He Arg Gly Val Glu Thr Asn Leu Val Glu He

180 185 190

Pro Ala Asn Trp Tyr Leu Asp Asp Leu Pro Pro Met Met Phe He Lys

195 200 205

Lys Ser Pro Asn Ser Phe Gly Phe Val Ser Pro Arg Asp He Gly Gin

210 215 220

Met Trp He Asp Gin Phe Asp Trp Val Tyr Arg Glu Met Asp Tyr Ala 225 230 235 240

Val Phe Ser Met Thr He His Pro Asp Val Ser Ala Arg Pro Gin Val 245 250 255 Leu Leu Met His Glu Lys He He Glu His He Asn Gin His Glu Gly

260 265 270

Val Arg Trp Val Thr Phe Asn Glu He Ala Asp Asp Phe Leu Lys Arg

275 280 285

Asn Pro Arg Lys Lys 290

(2) INFORMATION FOR SEQ ID NO: 972:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 136 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...136

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 972:

Val Cys Gly Val Leu Ser Leu Gin Ala Arg Leu Ser Phe Glu Asn Cys

1 5 10 15

Ser Lys Pro Leu Asp Cys Ser Leu Phe Ala Thr Thr Cys Thr Pro Gin

20 25 30

Asn Pro He Gly Ser Cys Met Val Ser Ser Gin Gly Gly Val Cys Gly

35 40 45

Val Leu Ser Leu Gin Ala Arg Leu Ser Phe Glu Asn Cys Ser Lys Pro

50 55 60

Leu Asp Cys Ser Leu Phe Ala Thr Thr Cys Thr Pro Gin Asn Pro He 65 70 75 80

Gly Ser Cys Met Val Ser Ser Gin Gly Gly Val Arg Gly Val Leu Ser

85 90 95

Leu Gin Ala Arg Leu Ser Phe Lys Asn Cys Phe Leu Val Lys Ser Leu

100 105 110

Lys Pro Ser Gin Leu Thr Leu Met Leu Thr Gly Phe Leu Gly Gly Phe

115 120 125

Ser Phe Leu Thr Thr Gly Phe Trp 130 135

(2) INFORMATION FOR SEQ ID NO: 973:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 360 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...360

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 973 :

Met Asn Gly Phe Cys Ala Arg Leu Arg Ala He Thr Phe Asn Glu Arg

1 5 10 15

Leu Lys Met Lys He Ala Val Leu Leu Ser Gly Gly Val Asp Ser Ser

20 25 30

Tyr Ser Ala Tyr Ser Leu Lys Glu Gin Gly His Glu Leu Val Gly He

35 40 45

Tyr Leu Lys Leu His Ala Ser Glu Lys Lys His Asp Leu Tyr He Lys

50 55 60

Asn Ala Gin Lys Ala Cys Glu Phe Leu Gly He Pro Leu Glu Val Leu 65 70 75 80

Asp Phe Gin Lys Asp Phe Lys Ser Ala Val Tyr Asp Glu Phe He Asn

85 90 95

Ala Tyr Glu Glu Gly Gin Thr Pro Asn Pro Cys Ala Leu Cys Asn Pro

100 105 110

Leu Met Lys Phe Gly Leu Ala Leu Asp His Ala Leu Lys Leu Gly Cys

115 120 125

Glu Lys He Ala Thr Gly His Tyr Ala Arg Val Lys Glu He Asp Lys

130 135 140

Val Ser Tyr He Gin Glu Ala Leu Asp Lys Thr Lys Asp Gin Ser Tyr 145 150 155 160

Phe Leu Tyr Ala Leu Glu His Glu Val He Ala Lys Leu Val Phe Pro

165 170 175

Leu Gly Asp Leu Leu Lys Lys Asp He Lys Pro Leu Ala Leu Asn Ala

180 185 190

Met Pro Phe Leu Gly Thr Leu Glu Thr Tyr Lys Glu Ser Gin Glu He

195 200 205

Cys Phe Val Glu Lys Ser Tyr He Asp Thr Leu Lys Lys His Val Glu

210 215 220

Val Glu Lys Glu Gly Val Val Lys Asn Leu Gin Gly Glu Val He Gly 225 230 235 240

Thr His Lys Gly Tyr Met Gin Tyr Thr He Gly Lys Arg Lys Gly Phe

245 250 255

Ser Val Lys Gly Ala Leu Glu Pro His Phe Val Val Gly He Asp Ala

260 265 270

Lys Lys Asn Glu Leu He Val Gly Lys Lys Glu Asp Leu Ala Thr His

275 280 285

Ser Leu Lys Ala Lys Asn Lys Ser Leu Thr Lys Asp Phe Lys Asp Gly

290 295 300

Glu Tyr Phe He Lys Ala Arg Tyr Arg Ser Val Pro Thr Lys Ala Phe 305 310 315 320

Val Ser Leu Lys Asp Gly Met He Glu Val Glu Phe Lys Glu Pro Phe

325 330 335

Tyr Gly Val Ala Lys Gly Gin Ala Leu Val Val Tyr Lys Asp Asp He

340 345 350

Leu Leu Gly Gly Gly Val He Val 355 360

(2) INFORMATION FOR SEQ ID NO: 974: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 357 ammo acids

(B) TYPE- ammo acid (D) TOPOLOGY: linear

(11) MOLECULE TYPE: protein

(m) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE-

(A) NAME/KEY: miscjeature

(B) LOCATION 1...357

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 974 :

Met Lys Ala Ser He Tyr Asp Phe Thr Leu Asp Glu Leu Ser Gin Leu

1 5 10 15

Leu Lys Pro Ser Phe Arg Ala Lys Gin Leu Tyr Leu Trp Leu Tyr Ala

20 25 30

Lys Tyr Lys Thr Ser Phe Lys Asp Met Gin Asn Asn Phe Ser Lys Asp

35 40 45

Phe He Ala Tyr Leu Glu Gin Glu Phe Thr Leu Arg Thr He Glu He

50 55 60

Ala His Val Arg Glu Ser Val Asp Gly Ser Lys Lys Tyr Leu Phe Lys 65 70 75 80

Ser Leu Arg Asp Asn His Thr Phe Glu Ala Val Leu Leu Lys Met Lys

85 90 95

Asp Lys Lys He Asp Glu Glu Thr Asn Ala Val Leu Glu Gly Glu Lys

100 105 110

Tyr Thr Val Cys Val Ser Cys Gin He Gly Cys Gin Val Gly Cys Ser

115 120 125

Phe Cys Phe Thr Gin Lys Gly Gly Phe Val Arg Asp Leu Lys Ala Ser

130 135 140

Glu He He Gin Gin Ala Leu Leu He Lys Glu Ala Asn Asn Leu Pro 145 150 155 160

He Glu Lys Ala Leu Asn He Val Phe Met Gly Met Gly Glu Pro Leu

165 170 175

Asn Asn Leu Asp Glu Val Cys Lys Ala Val Glu He Phe Asn Thr Gly

180 185 190

Met Gin He Ser Pro Lys Arg He Thr He Ser Thr Ser Gly Val Ala

195 200 205

Asp Lys He Pro He Leu Ala Gly Lys Asn Leu Gly Val Gin Leu Ala

210 215 220

He Ser Leu His Ala Val Asp Asp Lys Thr Arg Ser Ser Leu Met Pro 225 230 235 240

Leu Asn Lys Lys Tyr Asn He Glu Cys Val Leu Asn Glu Val Arg Lys

245 250 255

Trp Pro Leu Glu Gin Arg Lys Arg Val Met Phe Glu Tyr Leu Leu He

260 265 270

Lys Asp Leu Asn Asp Ser Leu Asp Cys Ala Lys Lys Leu Leu Lys Leu

275 280 285

Leu Asn Gly He Lys Ser Lys Val Asn Leu He Leu Phe Asn Pro His 290 295 300 Glu Gly Ser Lys Phe Glu Arg Pro Ser Leu Glu Ser Ala Arg Met Phe 305 310 315 320

Ala Asp Phe Leu Asn Ala Lys Gly Leu Leu Cys Thr He Arg Glu Ser

325 330 335

Lys Ala Leu Asp He Glu Ala Ala Cys Gly Gin Leu Arg Glu Lys Lys

340 345 350

Leu Gin Gin Lys He 355

(2) INFORMATION FOR SEQ ID NO: 975:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 468 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...468

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 975:

Met Ala Glu Trp Lys Thr Asp Thr Glu Glu Val Lys Lys Val Val Gly

1 5 10 15

Arg Cys Arg Glu Phe Lys Arg Ser Leu Gin Glu Glu Lys Cys Ser Pro

20 25 30

Phe He Lys Asp Leu Asp Ser Tyr Ala Leu Lys He He Val Glu Arg

35 40 45

Arg Lys Thr Glu Met Gin Leu Glu Lys Ala He Gly Glu Leu Lys Lys

50 55 60

Ala Lys Ser Asn Glu Asp Asp Ala Lys Val Ala Leu Arg Val Leu Gin 65 70 75 80

Gly Ala Ser Val Val Ser Trp He Trp Pro Pro Ala Arg He Ala Ala

85 90 95

Thr Ala Ala He Val Ala Ala Glu Ala Val Leu Lys Phe Met Lys Glu

100 105 110

Asp Thr Glu Lys Cys Lys Arg Asn Val Glu Leu Leu Glu Arg Met Leu

115 120 125

Glu He Tyr Ser Asn Gin Ala Lys Ala Ser Ala Asn Leu Met Asn Gin

130 135 140

Ala Trp Glu Gly He Lys Lys Arg Leu His Phe Tyr Thr Asp Lys His 145 150 155 160

Gin Glu Phe He Arg Arg Leu Lys Gin Ala Ser Asp Ala He Asp Asn

165 170 175

Glu Tyr Asn Phe Pro Thr Pro Gly Val Leu Leu Glu Tyr Asp Phe Glu

180 185 190

Arg Pro Ala He Ser Tyr Thr Pro Lys Lys Ser Val Phe Asn Glu Arg

195 200 205

Leu Lys Asp Leu Arg Glu Asn Phe Ser Ala Ser Leu Tyr Ala Asp Leu 210 215 220 Lys Asp Lys He His His Asn Ala Leu Ser Asn Asp Asp Leu Glu Arg 225 230 235 240

Met He Ala Phe Arg Glu Gin Glu Phe Glu Lys Ser Leu Glu Asp Trp

245 250 255

Met Gly Ala Tyr Ser Tyr Asp Glu Asn Pro Asn Asp Glu Leu Asp Arg

260 265 270

Met Ala He Ser Lys Glu Gin Glu Leu Glu Lys Ser Leu Glu Asp Leu

275 280 285

Met Pro Ser Val Leu Gly Val Pro Ser Tyr Asn Glu Ser Leu Thr Leu

290 295 300

Ala Lys Asn Arg Cys Val Lys Asn Phe Lys Glu Ala Leu Glu Gly Phe 305 310 315 320

Thr Glu Lys He Lys Glu Ser Pro Asn Asp Ser Asn Ala He Asn Glu

325 330 335

Ala Phe Asp Asn Leu Glu Thr Glu Leu Glu Arg Ala Thr Glu Asn Leu

340 345 350

Ser Gin Lys He Asp Pro Val Leu Glu Arg Asn Glu Asn Tyr Thr Gin

355 360 365

Lys Ala Leu Glu Tyr Arg Glu Phe Leu Glu Ser Arg Lys Glu Ser Phe

370 375 380

He Val Asp Glu Lys Asn Pro Tyr Pro Glu Glu Val Ser Phe Asn Glu 385 390 395 400

Trp Arg Trp Ala Glu Phe Asp Ser Val Phe Ser Ala He Val Pro Leu

405 410 415

Glu Asp Leu Asn Lys Thr Ala Cys Ala His His Ala Leu Lys Ala Leu

420 425 430

Gin Ala Thr Leu Lys Thr Thr He Trp Ala Leu Met Arg Gin Ser Trp

435 440 445

Asn Arg Ser Gin Lys Asp Ser Ser Leu Gly Gly He Cys Gly He Leu

450 455 460

Thr Arg Met Phe 465

(2) INFORMATION FOR SEQ ID NO: 976:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 268 ammo acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE -

(A) NAME/KEY: miscjeature

(B) LOCATION 1...268

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 976:

Met Lys Gin Ser Leu Arg Glu Gin Lys Leu Leu Lys He Leu Glu Asn 1 5 10 15

Asp Val Leu Thr He Leu Asp Ser Phe Ser Asn Tyr Leu Phe Glu Leu 20 25 30 Arg Glu Glu Leu Asp Phe He Glu Glu Glu Met Glu Gly Glu He Thr

35 40 45

Glu Gin Asn Leu Thr Ala Leu Tyr Asp Phe Ser Asn Phe Leu Glu Asp

50 55 60

His Val Asn Val Phe Tyr Glu Asn Val Leu Asn He Asp Asp Val Lys 65 70 75 80

Thr Glu His Leu Tyr Ser Gly Leu He Asp Ser Leu Asn Ala Asn Leu

85 90 95

His Phe Val Lys Ser Phe Leu Ser Asn Gin Asp Leu Asp Phe Arg Phe

100 105 110

Phe Lys Glu He Asn Asp Gly Gin Asp Pro Gin Lys Thr Leu Ser Arg

115 120 125

Leu He Pro Leu Gin Ser Gly Lys Asn Asp Ala Ser Ser Phe Lys Ala

130 135 140

Asn Asn Ser Phe Val Ser Leu Val Tyr Val Tyr Ala Tyr Phe Met Leu 145 150 155 160

Glu Thr He Arg Gin Ser Tyr Arg He Leu Arg Leu Leu Glu Lys Pro

165 170 175^'

He Asn Asn Asn He Ser Glu Asp Met Gin Ser Asp He Glu Asn Phe

180 185 190

Phe Val Gin Ala Asn Phe Leu Glu Tyr Tyr Val Gin Asn Lys He Tyr

195 200 205

Pro Thr Asn His Ala Tyr Asp Phe Thr His Leu He Met Asp Ser He

210 215 220

He Pro Asn Trp He Gin He Asp Met Ser Val Glu Ala Lys Lys Lys 225 230 235 240

Glu Leu Phe Glu Lys Tyr Phe Gin Asn He Asp Glu Val Thr Asn Lys

245 250 255

Met Leu Asp Gin Glu Asn Gin Asn Lys Asn Ser Asp 260 265

(2) INFORMATION FOR SEQ ID NO: 977:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 258 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL : YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...258

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 977:

Leu Leu Ser Asn Lys Thr Leu Pro Lys Arg Phe Ala Thr Tyr Ser Leu

1 5 10 15

Gin Glu Val Gly Val He Phe Leu Thr Thr Gin He Leu Ser He Met

20 25 30

Arg Lys Thr Arg Cys Ser Lys Thr Leu Phe Phe He Thr Arg Gly Arg 35 40 45 Glu Ser Phe Arg Tyr Gin Leu Cys Asp His Tyr Lys Gin Lys Arg His

50 55 60

Gin Phe Asp Glu Asp Phe Arg Ser Leu Leu Lys Ala Leu Lys He Ala 65 70 75 80

Leu Val Glu Lys Tyr Pro Leu Lys Lys Gly Ala Lys He Gin Gly Glu

85 90 95

His Cys Pne Glu Tyr Glu Ala Asp Asp He He Ser Phe Tyr Lys Lys

100 105 110

Lys Asp Pro Asn Asn Tyr Val He Ala Ser Met Asp Lys Asp He Leu

115 120 125

Tyr Ser Asn Arg Gly Ser His Phe Asn Leu Lys Thr Asn Ala Phe Phe

130 135 140

Asn Val Ser Gin Lys Glu Ala His Phe Phe Ala Tyr Tyr Gin Cys Val 145 150 155 160

Val Gly Asp Lys Gly Asp Asn He Lys Gly Val Lys Gly He Gly Gly

165 170 175

Phe Asn Tyr Lys Asp Phe Leu Asn Glu Asp Ala Lys Glu His Glu Leu

180 185 190

Trp Glu Gin He He Gin Ala Phe Lys He Lys Glu Asp Leu Ser Asp

195 200 205

Ser Glu Ala Lys Glu Lys Ala Leu Leu Asn Met Arg Leu Val Asn Met

210 215 220

His Gin Met Thr His His Gly Val He Lys Leu Trp Glu Pro Glu Phe 225 230 235 240

Lys Lys Ala Phe Phe Pro Lys Lys Pro Gin Arg Pro Asp Phe Lys Arg

245 250 255

He Ser

(2) INFORMATION FOR SEQ ID NO: 978:

(l) SEQUENCE CHARACTERISTICS.

(A) LENGTH: 256 ammo acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE.

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...256

( xi ) SEQUENCE DESCRI PTION . SEQ ID NO : 978 :

Leu Cys Leu Lys Leu Leu He Trp Asn Phe Lys Glu Hi s Ser Leu Lys

1 5 10 15

Val Asn Phe Phe Ala Thr Cys Leu Gly Ala Ala He Tyr Ser Asn Ala

20 25 30

Ser Leu Asn Ala He Lys Leu Leu Arg Lys Glu Asn Leu Glu Val Val

35 40 45

Phe Lys Lys Asp Gin Thr Cys Cys Gly Gin Pro Ser Tyr Asn Ser Gly 50 55 60 Tyr Tyr Glu Glu Thr Lys Lys Val Val Leu Tyr Asn He Lys Leu Tyr 65 70 75 80

Ser Asn Asn Asp Tyr Pro He He Leu Pro Ser Gly Ser Cys Thr Gly

85 90 95

Met Met Arg His Asp Tyr Leu Glu Leu Phe Glu Gly His Ala Glu Phe

100 105 110

Asn Met Vai Lys Asp Phe Cys Ser Arg Val Tyr Glu Leu Ser Glu Phe

115 120 125

Leu Asp Lys Lys Leu Gin Val Lys Tyr Glu Asp Lys Gly Glu Pro Leu

130 135 140

Lys He Thr Trp His Ser Asn Cys His Ala Leu Arg Val Ala Lys Val 145 150 155 160

He Asp Ser Ala Lys Asn Leu He Arg Gin Leu Lys Asn Val Glu Leu

165 170 175

He Glu Leu Glu Lys Glu Glu Glu Cys Cys Gly Phe Gly Gly Thr Phe

180 185 190

Ser Val Lys Glu Pro Glu He Ser Ala Val Met Val Lys Glu Lys He

195 200 205

Lys Asp He Glu Ser Arg His Val Asp Val He Val Ser Ala Asp Ala

210 215 220

Gly Cys Leu Met Asn He Ser Thr Ala Met Gin Lys Met Gly Ser Leu 225 230 235 240

Thr Lys Pro Met His Phe Tyr Asp Phe Leu Ala Ser Arg Leu Gly Leu 245 250 255

(2) INFORMATION FOR SEQ ID NO: 979:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 469 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...469

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 979 :

Leu Lys He Phe Val Leu Leu Met Ser Val He Leu Gly He Ser Leu

1 5 10 15

Thr Gly Cys He Gly Tyr Arg Met Asp Leu Glu His Phe Asn Thr Leu

20 25 30

Tyr Tyr Glu Glu Ser Pro Lys Lys Ala Tyr Glu Tyr Ser Lys Gin Phe

35 40 45

Thr Lys Lys Lys Lys Asn Ala Leu Leu Trp Asp Leu Gin Asn Gly Leu

50 55 60

Ser Ala Leu Tyr Ala Arg Asp Tyr Lys Thr Ser Leu Gly Val Leu Asp 65 70 75 80

Gin Ala Glu Gin Arg Phe Asp Lys Thr Gin Ser Ala Phe Thr Arg Gly 85 90 95 Ala Gly Tyr Val Gly Ala Thr Met He Asn Asp Asn Val Arg Ala Tyr

100 105 110

Gly Gly Asn He Tyr Glu Gly Val Leu He Asn Tyr Tyr Lys Ala He

115 120 125

Asp Tyr Met Leu Leu Asn Asp Ser Ala Lys Ala Arg Val Gin Phe Asn

130 135 140

Arg Ala Asn Glu Arg Gin Arg Arg Ala Lys Glu Phe Tyr Tyr Glu Glu 145 150 155 160

Val Gin Lys Ala He Lys Glu He Asp Ser Ser Lys Lys His Asn He

165 170 175

Asn Met Glu Arg Ser Arg Ala Glu Val Ser Glu He Leu Asn Asn Thr

180 185 190

Tyr Ser Asn Leu Asp Lys Tyr Glu Ala Tyr Gin Gly Leu Leu Asn Pro

195 200 205

Ala Val Ser Tyr Leu Ser Gly Leu Phe Tyr Ala Leu Asn Gly Asp Lys

210 215 220

Asn Lys Gly Leu Gly Tyr Leu Asn Glu Ala Tyr Gly He Ser Gin Ser 225 230 235 240

Pro Phe Val Ala Gin Asp Leu Val Phe Phe Lys Asn Pro Asn Arg Ser

245 250 255

His Phe Thr Trp He He He Glu Asp Gly Lys Glu Pro Gin Lys Ser

260 265 270

Glu Phe Lys He Asp Val Pro He Phe Met He Asp Ser Val Tyr Asn

275 280 285

Val Ser Val Ala Leu Pro Lys Leu Glu Lys Gly Glu Ala Phe Tyr Gin

290 295 300

Asn Phe Thr Leu Lys Asp Gly Glu Lys Val Thr Pro Phe Asp Thr Leu 305 310 315 320

Ala Ser He Asp Ala Val Val Ala Ser Glu Phe Arg Lys Gin Leu Pro

325 330 335

Tyr He He Thr Arg Ala He Leu Ser Ala Thr Phe Lys Val Gly Met

340 345 350

Gin Ala Val Ala Asn Tyr Tyr Leu Gly Phe Val Gly Gly Leu Val Thr

355 360 365

Ser Leu Tyr Ser Gly Val Ser Thr Phe Ala Asp Thr Arg Asn Thr Ser

370 375 380

He Phe Ala His Lys He Tyr Leu Met Arg He Lys Asn Lys Ala Phe 385 390 395 400

Glu Ser Tyr Glu Val Arg Ala Asp Ser He Asp Ala Phe Ser Phe Ser

405 410 415

Leu Lys Pro Cys Lys Arg Ser Leu Glu Ser Pro Lys He He Asp Ala

420 425 430

Arg Glu Leu Leu Ser Gly Phe Val Thr Ala Pro Gin Val Phe Cys Ser

435 440 445

Asn Arg His Asn He Leu Tyr Val Arg Ser Phe Lys Asn Gly Phe Val

450 455 460

Leu Ser His Leu Lys 465

(2) INFORMATION FOR SEQ ID NO: 980:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 350 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME/ KEY : mi scjeature

( B ) LOCATION 1 . . . 350

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 980 :

Met Lys Gin He Lys Ala Leu Ala Leu Phe Ser Gly Gly Leu Asp Ser

1 5 10 15

Leu Leu Ser Met Lys Leu Leu He Asp Gin Gly He Glu Val Thr Ala

20 25 30

Leu His Phe Asn He Gly Phe Gly Gly Asn Lys Asp Lys Arg Glu Tyr

35 40 45

Phe Glu Asn Ala Thr Ala Gin He Gly Ala Lys Leu Leu Val Cys Asp

50 55 60

He Arg Glu Gin Phe Phe Asn Asp Val Leu Phe Lys Pro Lys Tyr Gly 65 70 75 80

Tyr Gly Lys Tyr Phe Asn Pro Cys He Asp Cys His Ala Asn Met Phe

85 90 95

Arg Asn Ala Phe Tyr Lys Met Leu Glu Leu Asp Ala Asp Phe Val Leu

100 105 110

Ser Gly Glu Val Leu Gly Gin Arg Pro Lys Ser Gin Arg Lys Glu Ala

115 120 125

Leu Asn Gin Val Arg Lys Leu Val Arg Glu Val Gly Glu Glu Ala Arg

130 135 140

Phe Asp Leu He Leu Asp Arg Thr Gin Ala Ser Gly Glu Lys Pro Gin 145 150 155 160

Phe Leu Asp Glu Leu Leu Leu Arg Pro Met Ser Ala Lys Leu Leu Glu

165 170 175

Pro Thr Phe Met Glu Lys Lys Gly Trp Val Asp Arg Glu Lys Leu Leu

180 185 190

Asp Val Ser Gly Arg Gly Arg Ala Arg Gin Leu Gin Met He Lys Asp

195 200 205

Tyr Gly Leu Lys Tyr Tyr Glu Lys Pro Gly Gly Gly Cys Leu Leu Thr

210 215 220

Asp He Gin Val Ser Asn Lys He Lys Asn Leu Lys Glu Tyr Arg Glu 225 230 235 240

Met Val Phe Glu Asp Gly Val He Val Lys Asn Gly Arg Tyr Phe Val

245 250 255

Leu Pro His Asn Ala Arg Leu Val Val Ala Arg Asn Glu Glu Glu Asn

260 265 270

His Lys Leu Asp He Glu His Pro Leu Met Asp Lys He Glu Leu Leu

275 280 285

Gly Cys Lys Gly Pro Leu Ser Leu Val Asp Lys Asn Ala Ser Gin Glu

290 295 300

Asp Lys Glu Leu Ala Gly Arg He Ala Leu Gly Tyr Ala Lys Thr Leu 305 310 315 320

Lys Asn Gin Ala Tyr Leu He Gin He Gly Asn Glu Lys Arg Glu Leu

325 330 335

Tyr Pro Leu Asp Lys Glu Asn Ala Arg Glu Tyr Leu Phe Ala 340 345 350 (2) INFORMATION FOR SEQ ID NO: 981:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 405 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 405

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 981 :

Met Lys Lys Tyr Ser Ala He Pro Thr Pro Cys Tyr Ala Leu Glu Ser

1 5 10 15

Glu Arg Leu Glu Lys Asn Ala Lys He Leu Glu He Val Arg Gin Gin

20 25 30

Ser Gly Ala Lys Val Leu Leu Ala Leu Lys Gly Tyr Ala Phe Trp Arg

35 40 45

Glu Phe Gly He Leu Arg Gin Lys Leu Asn Gly Cys Cys Ala Ser Gly

50 55 60

Leu Tyr Glu Ala Lys Leu Ala Phe Glu Glu Phe Gly Gly Arg Glu Ser 65 70 75 80

His Lys Glu He Cys Val Tyr Ser Pro Ala Phe Lys Glu Ala Glu Met

85 90 95

Ser Ala He Leu Pro Leu Ala Thr Ser He He Phe Asn Ser Phe His

100 105 110

Gin Tyr Ala Thr Tyr Lys Asp Arg He Leu Asp Lys Asn Lys Gin Leu

115 120 125

Glu Asn Leu Gly Leu Ser Pro He Lys Met Gly Leu Arg He Asn Pro

130 135 140

Leu Tyr Ser Glu Val Thr Pro Ala He Tyr Asn Pro Cys Ser Lys Met 145 150 155 160

Ser Arg Leu Gly He Thr Pro Ser Gly Phe Glu Lys Gly Val Lys Glu

165 170 175

His Gly Leu Glu Gly Val Ser Gly Leu His Phe His Thr His Cys Glu

180 185 190

Gin Asn Ala Asp Ala Leu Cys Arg Thr Leu Glu His Val Glu Arg His

195 200 205

Phe Lys Pro Tyr Leu Glu Asn Met Ala Trp Val Asn Phe Gly Gly Gly

210 215 220

His His He Thr Arg Ser Asp Tyr Asp Val Asn Leu Leu He Gin Thr 225 230 235 240

He Lys Asp Phe Lys Glu Arg Tyr His Asn Thr Glu Val He Leu Glu

245 250 255

Pro Gly Glu Ala He Gly Trp Gin Cys Gly Phe Leu He Ala Ser Val

260 265 270

He Asp He Val Gin Asn Asp Gin Glu He Ala He Leu Asp Ala Ser

275 280 285

Phe Ser Ala His Met Pro Asp Cys Leu Glu Met Pro Tyr Arg Pro Ser 290 295 300

He Leu Lys Val Ser Val Glu Asn Asp Glu Glu He He Glu Val Glu 305 310 315 320

Lys Gly Glu Asn Gin Gly Ala Phe Ser Tyr Phe Leu Gly Gly Pro Thr

325 330 335

Cys Leu Ala Gly Asp Phe Met Gly Ser Phe Ser Phe Glu Thr Pro Leu

340 345 350

Lys Arg Gly Asp Lys He Val Phe Gin Asp Met Leu His Tyr Thr He

355 360 365

Val Lys Asn Asn Ser Phe Asn Gly Val Pro Leu Pro Ser Leu Ala Lys

370 375 380

He Asp Ser Gin Gly Phe Lys He Leu Lys Ser Phe Ser Tyr Glu Asp 385 390 395 400

Tyr Lys Asn Arg Asn 405

(2) INFORMATION FOR SEQ ID NO: 982:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 321 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 321

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 982 :

Met Ala Asp Ser Leu Ala Gly He Asp Gin Val Thr Ser Leu Hi s Lys

1 5 10 15

Asn Asn Glu Leu Gin Leu Leu Cys Phe Arg Leu Gly Lys Asn Lys Asp

20 25 30

Leu Tyr Ala Val Asn Val Phe Lys He Arg Glu Val Val Lys Tyr His

35 40 45

Gly Asn Leu Thr He He Ser His Glu Asn Asn Ser Leu Val Glu Gly

50 55 60

Leu He He He Arg Glu Leu Thr He Pro Leu He Asp Met Lys Lys 65 70 75 80

Trp Phe Tyr Tyr Asp Ser Gin Asn Lys Ser Lys Asp Leu Arg Pro Tyr

85 90 95

Arg He Glu Lys Glu Lys Gly Glu Asp Asp He Val Met He Cys Glu

100 105 110

Phe Ser Arg Trp Thr He Gly Val Arg He Tyr Glu Ala Asp Arg He

115 120 125

Leu Ser Lys Lys Trp Thr Glu Met Glu Gin Ser Ala Gly Leu Gly Gly

130 135 140

Ser Ala Gly Asn Asn Lys Leu Val Ser Arg Thr Arg Tyr Phe Asp Gly 145 150 155 160

Arg Leu Val Gin Val Val Asp He Glu Lys Met Leu He Asp Val Phe 165 170 175

Pro Trp He Glu Asp Glu Lys His Asn Asp Leu Glu Thr Leu Ser Lys

180 185 190

He His Ser Asn Gin Cys Val Leu Leu Ala Asp Asp Ser Pro Ser Val

195 200 205

Leu Lys Thr Met Gin Met He Leu Asp Lys Leu Gly Val Lys His He

210 215 220

Asp Phe He Asn Gly Lys Thr Leu Leu Glu His Leu Phe Asn Pro Thr 225 230 235 240

Thr Asp Val Ser Asn He Gly Leu He He Thr Asp Leu Glu Met Pro

245 250 255

Glu Ala Ser Gly Phe Glu Val He Lys Gin Val Lys Asn Asn Pro Leu

260 265 270

Thr Ser Lys He Pro He Val Val Asn Ser Ser Met Ser Gly Ser Ser

275 280 285

Asn Glu Asp Met Ala Arg Ser Leu Lys Ala Asp Asp Phe He Ser Lys

290 295 300

Ser Asn Pro Lys Asp He Gin Arg Val Val Lys Gin Phe Leu Glu Leu 305 310 315 320

Ala

(2) INFORMATION FOR SEQ ID NO: 983:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 735 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...735

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 983:

ATGCAATTTC AAAAAACCTT ATCTTCCTTA TCTTTATTTT TATCTTTATC TTTATTCTTA 60

TCTTTTAGTA TCGCTGAAGA AAATGGGGCG TATGCGAGCG TGGGTTTTGA ATATTCCATT 120

AGTCATGCCG TTGAGCACAA TAATCCCTTT TTAAATCAAG AACGCATCCA AACGATTTCT 180

AACGCTCAAA ACCAAATCTA TAAACTCAAT CAAATTGAAA ATGAAATCAC AAACATGCAA 240

AACACCTTTA ACTACACCAA CAACGCTTTG AAAAACAATG CTAAATTAAC CCCCACTGAA 300

ATGCAAGCCG AACAATACTA CCTCCAATCC ACCCTTCAAA ACATTGAAAA AATAGTCATG 360

CTTAGCGGTG GCGTTGCGTC TAACCCTAAA CTAGTCCAAG CGTTAGAAAA AATGCAAGAA 420

CCCATTACTA ACCCTTTAGA ATTGGTAGAA AACTTAAAAA ATTTAGAATT ACAATTCAGC 480

CAATCTCAAA ACAGCATGCT TTCTTCTTTG TCTTCTCAGA TCGCTCAAAT TTCAAATTCT 540

TTGAACGCGC TTGATCCCAG CTCTTATTCT AAAAACGTTT CAAGCATGTA TGGGGTAGGT 600

TTGAGCGTAG GGTATAAGCA TTTCTTTACC AAGAAAAAAA ATCAAGGGTT TCGTTATTAC 660

TTATTCTATG ACTATGGTTA CACTAATTTT GGTTTTGTGG GTAATGGCTT TGATGGTTTA 720 GGCAAAATGA ATAAC 735 (2) INFORMATION FOR SEQ ID NO- 984:

(1) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1899 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY- circular

(11) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...1899

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 984:

ATGAAACCAA CGAACGAACC TAAAAAACCT TTTTTTCAAA GTCCCATTGT TCTTGCGGTT 60

CTTGGAGGGA TTTTACTCAT TTTTTTCCTA CGCTCTTTCA ATTCTGATGG CAGTTTTTCG 120

GACAATTTCT TAGCTTCTAG CACTAAAAAT GTGAGCTACC ATGAAATCAA ACAGCTCATC 180

AGCAATAATG AAGTGGAAAA TGTGAGTATC GGTCAAACTT TGATCAAAGC CAGCCATAAA 240

GAGGGCAATA ATCGTGTGAT TTATATCGCT AAACGAGTGC CTGATCTAAC CTTAGTGCCT 300

TTGTTAGACG AGAAAAAAAT CAATTATTCT GGTTTTAGCG AATCTAACTT TTTTACCGAC 360

ATGTTAGGGT GGCTCATGCC TATTTTAGTG ATTTTAGGGC TATGGATGTT TATGGCAAAC 420

CGCATGCAAA AAAATATGGG TGGGGGTATT TTTGGCATGG GGAGCGCGAA AAAACTCATT 480

AACGCTGAAA AACCCAATGT GCGTTTTAAT GACATGGCGG GCAATGAAGA AGCCAAAGAA 540

GAAGTAGTAG AAATCGTGGA TTTCTTAAAA TACCCCGAAC GATACGCCAA TTTAGGGGCT 600

AAAATCCCTA AAGGTGTGCT GTTAGTAGGG CCTCCAGGAA CCGGTAAAAC CCTTTTAGCA 660

AAGGCGGTGG CTGGCGAAGC GCATGTGCCG TTTTTCTCTA TGGGAGGGAG CAGTTTCATT 720

GAAATGTTTG TGGGCTTAGG GGCAAGCAGG GTTAGGGATT TGTTTGAAAC CGCTAAAAAA 780

CAAGCCCCTA GCATCATTTT TATTGATGAA ATTGATGCCA TAGGCAAGAG CAGAGCGGCT 840

GGAGGCATGA TAAGTGGGAA TGATGAGAGA GAGCAAACCC TAAACCAGCT CTTAGCCGAA 900

ATGGATGGTT TTGGGAGCGA AAACGCACCT GTCATTGTTT TAGCCGCAAC GAACCGCCCT 960

GAAATCTTGG ATCCGGCTTT AATGCGTCCA GGGCGCTTTG ACAGGCAGGT TTTAGTGGAT 1020

AAGCCTGATT TTAATGGCAG GGTGGAAATC TTAAAAGTGC ATATTAAAGG CGTGAAACTC 1080

GCTAATGATG TGAATTTGCA AGAAGTCGCC AAACTCACCG CAGGGCTTGC AGGGGCGGAT 1140

TTGGCGAATA TCATCAATGA AGCCGCGCTT TTAGCGGGAC GAAACAACCA AAAAGAAGTC 1200

AAACAACAGC ATTTAAAAGA AGCGGTTGAA AGAGGGATTG CTGGGCTAGA AAAGAAAAGC 1260

AGGCGTATCA GTCCTAAAGA AAAGAAAATC GTCGCCTACC ATGAAAGCGG GCATGCCGTG 1320

ATTTCTGAAA TGACTAAAGG GAGCACTAGG GTGAATAAAG TCTCTATCAT TCCAAGGGGC 1380

ATGGCGGCTT TAGGCTACAC CCTTAACACG CCTGAAGAAA ACAAATACTT GATGCAAAAA 1440

CACGAACTCA TCGCTGAAAT TGATGTGCTT TTAGGCGGGA GGGCGGCTGA AGAAGTCTTT 1500

TTAGAAGAAA TTTCTACCGG TGCGAGCAAC GATTTAGAAA GAGCGACTGA TATTATTAAA 1560

GGCATGGTGA GTTACTACGG CATGAGCAGT GTCAGCGGGC TTATGGTGTT AGAAAAGCAA 1620

CGGAACGCCT TTTTAGGAGG CGGTTATGGG AGCAGTAGGG AATTTAGCGA AAAAACCGCA 1680

GAAGAAATGG ATCTTTTCAT TAAAAACCTA CTAGAAGAGC GCTATCAGCA TGTCAAACAA 1740

ACCTTAAGCG ACTATAGAGA GGCGATTGAA ATCATGGTCA AAGAATTGTT TGACAAAGAA 1800

GTCATTACAG GCGAAAGGGT GCGTGAAATC ATCAGCGAAT ACGAAGCCGC CAACAATTTA 1860

GAAAGCCGTT TGATCCCTTT AGAAGAGCAA GCGAGTTAA 1899 (2) INFORMATION FOR SEQ ID NO: 985:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3867 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...3867

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:985:

ATGGAAATAC AACAAACACA CCGCAAAATC AATCGCCCTT TAGTTTCTCT CGTTTTAGCA 60

GGAGCGTTGA TTAGCGCCAT ACCGCAAGAG AGTCATGCCG CCTTTTTCAC GACCGTGATC 120

ATTCCAGCCA TTGTTGGGGG TATCGCCACA GGCACTGCTG TAGGAACGGT CTCAGGGCTT 180

CTTAGTTGGG GACTCAAACA AGCCGAAGAA GCGAATAAAA CCCCAGATAA ACCCGATAAA 240

GTTTGGCGCA TTCAAGCAGG AAAAGGCTTT AATGAATTTC CTAACAAGGA ATACGACTTA 300

TACAAATCCC TTTTATCCAG TAAGATTGAT GGAGGTTGGG ACTGGGGGAA CGCCGCTAGG 360

CATTATTGGG TCAAAGGCGG GCAATGGAAC AAGCTTGAAG TGGATATGAA AGACGCTGTA 420

GGGACTTATA AACTATCAGG GCTTAGAAAC TTTACTGGTG GGGATTTAGA CGTGAATATG 480 CAAAAAGCCA CTTTGCGTTT GGGCCAATTC AATGGCAATT CTTTCACAAG CTATAAGGAT 540 AGCGCTGATC GCACCACGAG AGTGAATTTC AACGCTAAAA ATATTTCAAT TGATAATTTT 600 GTAGAAATCA ATAATCGTGT GGGTTCTGGA GCCGGGAGAA AAGCCAGCTC TACGGTTTTG 660 ACTTTGCAAG CTTCAGAAGG GATCACTAGC AGTAAAAATG CGGAAATTTC TCTTTATGAT 720 GGCGCCACGC TCAATTTGGC TTCAAACAGC GTTAAATTAA ATGGTAATGT GTGGATGGGC 780 CGTTTGCAAT ACGTGGGAGC GTATTTAGCC CCTTCATACA GCACGATCAA CACTTCAAAA 840 GTTCAAGGGG AAGTGGATTT TAACCATCTC ACTGTGGGGG ATCAAAACGC CGCTCAAGCG 900 GGCATTATCG CTAGCAATAA GACTCATATT GGCACACTGG ATTTGTGGCA AAGCGCCGGG 960

TTAAATATCA TTGCCCCTCC AGAAGGTGGC TACAAGGATA AACCTAATAG TACCACTTCT 1020

CAAAGTGGCA CTAAAAACGA CAAGAAAGAG ATCAGTCAAA ATAACAATAG CAACACAGAG 1080

GTCATTAACC CACCCAATAA CACGCAAAAA ACAGAAACTG AACCCACGCA AGTCATTGAT 1140

GGGCCTTTTG CTGGCGGCAA AGACACGGTT GTCAATATTT TCCACTTAAA CACTAAAGCC 1200

GATGGCACGA TTAAAGTGGG AGGGTTTAAA GCTTCTCTTA CCACGAATGC GGCTCATTTG 1260

AATATCGGCA AAGGCGGTGT CAATCTGTCC AATCAAGCGA GCGGGCGCAC CCTTTTAGTG 1320

GAAAATCTAA CCGGGAATAT CACCGTTGAT GGGCCTTTAA GAGTGAATAA TCAAGTGGGT 1380

GGCTATGCTT TGGCAGGATC AAGCGCGAAT TTTGAGTTTA AGGCTGGTGT GGATACTAAA 1440

AACGGCACAG CCACTTTCAA TAACGATATT AGTTTGGGAA GATTTGTGAA TTTAAAGGTG 1500

GATGCTCATA CAGCTAATTT TAAAGGTATT GATACGGGTA ATGGTGGTTT CAACACCTTA 1560

GATTTTAGTG GTGTTACAGA CAAAGTCAAT ATCAACAAGC TCATCACAGC TTCCACTAAT 1620

GTGGCCGTTA AAAACTTCAA CATTAATGAA TTGATTGTTA AAACCAATGG GATAAGTGTG 1680

GGGGAATACA CTCATTTTAG CGAAGATATA GGCAGTCAAT CGCGTATCAA TACCGTGCGT 1740

TTGGAAACTG GCACTAGGTC AATCTTTTCT GGGGGTGTCA AATTTAAAAG CGGTGAAAAA 1800

CTAGTTATCA ATGATTTTTA CTATAGCCCT TGGAATTATT TTGACGCTAG GAATGTTAAA 1860

AATGTTGAAA TCACCAGAAA ATTCGCTTCT TCAACCCCAG AAAACCCTTG GGGCACATCA 1920

AAGCTCATGT TTAATAATCT AACCTTGGGT CAAAATGCGG TCATGGACTA TAGTCAATTT 1980 TCAAATTTAA CCATTCAGGG GGATTTTATC AACAATCAAG GCACTATCAA CTATCTGGTC 2040

CGAGGCGGGA AAGTGGCAAC CTTAAATGTA GGCAATGCAG CAGCTATGAT GTTTAATAAT 2100

GATATAGACA GCGCGACCGG ATTTTACAAA CCGCTCATCA AGATTAACAG CGCTCAAGAT 2160

CTCATTAAAA ATACAGAGCA TGTTTTATTG AAAGCGAAAA TCATTGGTTA TGGTAATGTT 2220

TCTACAGGTA CCAATGGCAT TAGTAATGTT AATCTAGAAG AGCAATTCAA AGAGCGCCTA 2280

GCCCTTTATA ACAATAATAA CCGCATGGAT ACTTGTGTGG TGCGAAATAC TGATGACATT 2340

AAAGCATGCG GTATGGCTAT CGGCAATCAA AGCATGGTGA ACAACCCTGA CAATTACAAG 2400

TATCTTATCG GTAAGGCATG GAGAAATATA GGCATCAGTA AAACGGCTAA CGGCTCTAAA 2460

ATTTCGGTGT ATTATTTAGG CAATTCTACG CCTACTGAGA ATGGTGGCAA TACCACCAAC 2520

TTACCCACAA ACACCACTAA TAATGCGCAT TCTGCTAACT ACGCTCTCGT GAAGAACGCT 2580

CCTTTCGCTC ACAGCGCCAC TCCTAATTTA GTCGCTATCA ATCAGCATGA TTTTGGCACT 2640

ATTGAGAGCG TGTTTGAATT GGCTAACCGC TCTAAAGATA TTGACACGCT CTATACTCAT 2700

TCAGGCGCGC AAGGCAGGGA TCTCTTGCAA ACTTTATTGA TTGATAGCCA TGATGCGGGT 2760

TATGCCAGAC AAATGATTGA TAACACAAGC ACCGGTGAAA TCACCAAGCA ATTGAATGCG 2820

GCCACTGACG CTTTAAACAA CGTAGCCAGT TTAGAGCATA AACAAAGCGG CTTACAAACC 2880

TTGAGCTTGA GTAATGCGAT GATTTTAAAT TCTCGTTTAG TCAATCTCTC TAGGAAGCAC 2940

ACCAACCATA TTAACTCGTT CGCTCAACGC TTACAAGCTT TAAAAGGCCA AGAATTCGCT 3000

TCTTTAGAGA GCGCGGCAGA AGTGTTGTAT CAATTTGCCC CTAAATATGA AAAACCTACC 3060

AATGTTTGGG CTAACGCTAT TGGGGGAGCG AGCTTGAATA GCGGCTCTAA CGCTTCATTG 3120

TATGGCACAA GCGCCGGCGT AGACGCTTTC CTTAACGGGA ATGTGGAAGC CATTGTGGGC 3180

GGTTTTGGAA GCTATGGTTA TAGCTCCTTT AGCAATCAAG CGAACTCTCT TAACTCTGGG 3240

GCCAATAACG CTAATTTTGG CGTGTATAGC CGTTTTTTTG CCAACCAGCA TGAATTTGAC 3300

TTTGAAGCTC AAGGGGCGCT AGGGAGCGAT CAATCAAGCT TGAATTTCAA AAGCACTCTA 3360

TTACAAGATT TGAATCAAAG CTATAATTAC TTAGCCTATA GCGCCACAGC AAGAGCGAGT 3420

TATGGTTATG ACTTCGCGTT TTTTAGGAAC GCTTTAGTGT TAAAACCAAG CGTGGGCGTG 3480

AGCTATAACC ATTTAGGTTC AACCAACTTT AAAAGCAATA GCCAATCACA AGTGGCTTTA 3540

AAAAATGGCG CGAGCAGTCA GCATTTATTC AACGCTAACG CTAACGTGGA AGCGCGTTAT 3600

TATTATGGGG ACACTTCATA CTTTTATTTG CATGCGGGAG TTTTACAAGA GTTCGCTCAC 3660

TTTGGATCGA ATGATGTGGC GTCTTTAAAC ACCTTTAAAA TCAATGCCGC TCGCAGTCCT 3720

TTAAGCACCT ATGCAAGAGC GATGATGGGT GGGGAATTGC AATTGGCTAA AGAAGTGTTT 3780

TTGAATTTGG GCGTGGTTTA TTTGCACAAT TTGATTTCCA ACGCAAGCCA TTTCGCTTCC 3840

AATTTAGGAA TGAGGTATAG TTTCTAA 3867

(2) INFORMATION FOR SEQ ID NO: 986:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4455 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...4455

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 986: GGGGCGGTCT CTTTACGAGG GCAGTTTAAT TTAAGCAATA ATTCTTCTTT AGATTTTCAA 60 GGCTCTAGCG CTATCACCTC TAACACGGCG TTTAATTTCT ATGATAACGC TTTTTCTCAA 120

AGCCCCATCA CTTTCCATCA AGCCCTTGAC ATTAAAGTGC CCTTGAGTTT GGGAGGCAAC 180

CTCTTAAACC CTAACAACAG TAGCGTGCTG AATTTAAAAA ACAGCCAGCT TGTTTTTAGC 240

GATCAAGGGA GCTTGAATAT CGCTAACATT GATTTACTAA GCGATCTGAA TGGTAATAAA 300

AATCGTGTGT ATAACATCAT TCAAGCGGAC ATGAATGGTA ATTGGTATGA GCGTATCAAC 360

TTCTTTGGCA TGCGCATTAA TGATGGGATT TATGACGCTA AAAACCAAAC TTATAGTTTC 420

ACTAACCCTC TCAATAACGC CCTAAAAATC ACCGAGAGCT TTAAAAATAA CCAACTGAGC 480

GTTACGCTCT CTCAAATCCC GGGCATTAAA AACACGCTCT ATAACATTGG CTCTGAAATC 540

TTTAACTACC AAAAGGTTTA TAACAACGCT AATGGCGTGT ATTCTTATAG CGATGACGCA 600

CAAGGCGTGT TTTATCTCAC GAGCAGCGTG AAAGGCTATT ACAACCCCAA CCAATCCTAT 660

CAAGCCAGCG GCAGCAATAA CACCACGAAA AATAACAATC TAACCTCTGA ATCTTCTGTC 720

ATTTCGCAAA CCTATAACGC GCAAGGCAAC CCTATCAGCG CGTTACACGT CTATAACAAG 780

GGCTATAATT TCAGTAATAT CAAAGCGTTA GGGCAAATGG CGCTCAAACT CTACCCTGAA 840

ATCAAAAAGA TATTAGGGAA TGATTTTTCG CTTTCAAGTT TGAGCAATTT AAAAGGCGAT 900

GCGCTAAACC AGCTTACCAA GCTCATCACG CCTAGCGATT GGAAAAACAT TAACGAGTTG 960

ATTGATAACG CAAACAATTC GGTCGTGCAA AATTTCAATA ACGGCACTTT GATTATAGGA 1020

GCGACTAAAA TAGGGCAAAC AGACACCAAT AGTGCGGTGG TTTTTGGGGG CTTGGGCTAT 1080

CAAAAGCCTT GCGATTACAC TGATATTGTG TGCCAAAAAT TTAGAGGCAC TTATTTGGGG 1140

CAGCTTTTGG AGTCCATCTC GGCTGATTTG GGCTATATTG ACACGACTTT TAACGCTAAA 1200

GAAATTTATC TTACCGGCAC TTTAGGGAGC GGGAACGCAT GGGGGACTGG GGGGAGTGCG 1260

AGCGTAACTT TTAACAGCCA AACTTCGCTC ATTCTCAACC AAGCGAATAT CGTAAGCTCG 1320

CAAACCGATG GGATTTTTAG CATGCTGGGT CAAGAGGGCA TCAATAAGGT TTTCAATCAA 1380

GCCGGGCTCG CTAATATTTT GGGCGAAGTG GCAATGCAAT CCATTAACAA AGCCGGGGGA 1440

TTAGGGAATT TGATAGTAAA TACGCTAGGG AGTGATAGCG TGATTGGGGG GTATTTAACG 1500

CCTGAGCAAA AAAATCAAAC CCTAAGCCAG CTTTTGGGGC AGAATAATTT TGATAACCTC 1560

ATGAACGATA GCGGTTTGAA CACGGCGATT AAGGATTTGA TCAGACAAAA ATTAGGCTTT 1620

TGGACCGGGC TAGTGGGGGG ATTAGCCGGA CTGGGGGGCA TTGATTTGCA AAACCCTGAA 1680

AAGCTTATAG GCAGCATGTC CATCAATGAT TTATTGAGTA AAAAGGGGTT GTTCAATCAG 1740

ATCACCGGCT TTATTTCCGC TAACGATATA GGGCAAGTCA TAAGCGTGAT GCTGCAAGAT 1800

ATTGTCAAGC CGAGCGACGC TTTAAAAAAC GATGTAGCCG CTTTGGGCAA GCAAATGATT 1860

GGCGAATTTT TAGGCCAAGA CACGCTCAAT TCTTTAGAAA GCTTGCTGCA AAACCAGCAG 1920

ATTAAAAGCG TTTTAGACAA AGTCTTAGCG GCTAAAGGAT TAGGGTCTAT TTATGAACAA 1980

GGTTTGGGGG ATTTGATCCC TAATCTTGGT AAAAAGGGGA TTTTCGCTCC CTATGGCTTG 2040

AGTCAAGTGT GGCAAAAAGG GGATTTTAGT TTCAACGCGC AAGGCAATGT TTTTGTGCAA 2100

AATTCCACTT TCTCTAACGC TAATGGAGGC ACGCTCAGTT TTAACGCAGG AAATTCGCTC 2160

ATTTTTGCCG GAAACAACCA CATCGCTTTC ACTAACCATT CTGGAACGCT CAATTTGTTG 2220

TCTAATCAAG TTTCTAACAT TAACGTCACC ATGCTTAACG CTAGCAACGG CCTTAAGATT 2280

AACGCCACTA ATAACAATGT TTCCGTGTCT CAAGGCAATC TGTTTATCAA CGCTAGCTGC 2340

GTGCAACAAA GCGATCCAAC GACAGCTAGC GCCACAAACC CTTGCACCAC CGCTCAAAAT 2400

AACGCTTCTT CTAGTAATGC GTCAAACAAC GCGCCAATCG CCTTAAATAA TAACGATGAA 2460

AGCTTGGTGG TTACGGCGAA TGGTTTCAAT TTTTCAGGCA ATATTTACGC TAACGGGGTG 2520

GTTGATTTTT CAAAAATTAA AGGCTCTGCA AACGTTAAAA ACCTGTATCT TTACAATAAC 2580

GCTCAATTCC AAGCCAACAA CCTCACGATT TCCAACCAAG CGGTATTAGA GAAAAACGCT 2640

AGCTTTGTAA CGAATAACTT AAACATTCAA GGAGCGTTTA ACAACAACGC CACGCAAAAA 2700

ATAGAGGTGC TTCAAAATTT AGTGATCGCT TCAAACGCTT CTTTAAGCAC CGGGATTTAT 2760

GGGTTAGAAG TAGGGGGGGC ATTGAATAAT TTGGGAGCGA TCCATTTTAA TTTAGAAAAT 2820

TCTCAAACGC CTGTAAATCC GCTCATTCAA GTAGGGGGGA TCATTAATCT CAACACCACC 2880

CAAACGCCTT TTATGAATGT CAGCGTGGCT AATGGCGGAA CTTACACTTT ATTAAAAAGC 2940

AGCCGTTATA TTGATTACAA TATCAACCCT AACAGCTTGC AATCGTATTT GAAGCTCTAT 3000

ACCTTAATCA ATATCAACGG AAACCACATA GAGGAAAAAA ACGGCGTATT GACTTATTTG 3060

GGCCAACGGG TTTTATTACA AGATAAGGGG TTATTATTGA GTGTAGCACT ACCTAACTCA 3120

AACAACGCCT CTCAAAACAA CATTTTAAGC CTTTCTGTCC TTCACAACCA GATTAAAATG 3180

TCTTATGGTA ATAAAGTGAT GGACTTTACC CCTCCCACCT TACAGGATTA CATTGTGGGC 3240

ATTCAAGGAC AAAGCGCACT CAATCAAATT GAAGCTGTTG GGGGGAATAA CGCTATCAAG 3300

TGGCTTTCAA CATTGATGAT GGAGACTAAA GAAAACCCGC TTTTTGCGCC GATTTATTTA 3360

GAAAACCACT CTTTAAATGA AATCTTAGGC GTAACAAAAG ATCTTCAAAA CACCGCAAGC 3420

TTGATTTCTA ACCCTAATTT TAGAAATAAC GCTACCAGCC TTTTAGAAAT GGCGAGTTAC 3480 ACCCAACAAA CCAGCCGTTT GACAAAACTC TCTGATTTTA GGGCTAGAGA GGGAGAGTCC 3540

AATTTTTCAG AGCGCTTGTT AGAGCTTAAA AACAAGCGTT TTAGCGATCC TAACCCTAGT 3600

GAGGTTTTTG TCAAATACTC TCAACTCAGC AAACACCCCA ATAACCTTTG GATTCAAGGG 3660

GTGGGAGGAG CGAGCTTTAT TTCTGGGGGC AATGGCACGC TTTATGGCTT GAATGTGGGC 3720

TATGACCGAT TGGTTAAAAG CGTGATCCTT GGGGGTTATG TGGCTTATGG CTATAGCGGT 3780

TTTAACGGGA ACATCATGCA TTCTTTGGCT AATAATGTGG ATGTGGGGAT GTATGCGAGG 3840

GCTTTTTTGA AAAGAAACGA ATTCACTTTG AGCGCGAATG AAACTTATGG AGGCAATGCG 3900

AGTCATATCA ATTCTTCTAA TTCCTTGCTC TCTGTGTTGA ACCAACGCTA CAACTACAAC 3960

ACCTGGACAA CGAGCGTGAA TGGGAATTAC GGCTATGATT TCATGTTCAA ACAAAAAAGC 4020

GTGGTGCTAA AACCTCAAGT GGGCTTGAGC TATCATTTCA TAGGCTTGAG CGGGATGAAA 4080

GGTAAAATGC AAAATCCAGC TTACCAACAA TTCGTCATGC ATTCAAACCC TTCTAACGAA 4140

TCGGTTTTAA CGCTCAACAT GGGGTTAGAG AGCCGTAAAT ATTTTGGTAA AAATTCCTAT 4200

TATTTTGTAA CGGCGAGGTT GGGTAGGGAT CTTTTGATCA AAGCTAAAGG CGACAATGTG 4260

GTGCGTTTTG TGGGTGAAAA CACTTTATTG TACCGCAAGG GGGAAATTTT TAACACTTTT 4320

GCGAGCGTGA TCACAGGAGG CGAAATGCAT TTGTGGCGTT TGATGTATGT GAATGCGGGG 4380

GTGGGGCTTA AAATGGGCTT GCAATACCAA GATCTTAATA TCACTGGGAA TGTGGGCATG 4440

CGAGTGGCGT TTTAG 4455

(2) INFORMATION FOR SEQ ID NO: 987:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 903 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME /KEY : miscjeature

( B ) LOCATION 1 . . . 903

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 987:

ATGAGAAAAA CGATTTCAGC GTTGTTTTTA TCAGCGTGTA TAGGGTTATC GTCTGTTCAT 60

GCGAGTAACG CTTTGATTTT ACAAACAGAT TTTAGCCTAA AAGATGGGGC CGTCTCGGCG 120

ATGAAAGGCG TCGCTTTCAG CGTTGATTCT AATCTTAAAA TCTTTGATTT AACGCACGAA 180

ATCCCCCCGT ATAACATTTG GGAAGGCGCT TACCGCTTGT ATCAGACCGC TAGTTATTGG 240

CCAAAAGGCT CGGTATTTGT GAGCGTAGTG GATCCGGGCG TAGGCACTAA TCGTAAATCG 300

GTGGTATTGA AAACTAAAAA CGGCCAGTAT TTCGTCTCTC CAGATAACGG CACGCTGACT 360

TTGGTAGCGC AAACTTTGGG GATTGATAGC GTGCGTGAAA TTGATGAAAA AGCCAACCGC 420

TTGAAAGGTT CTGAAAAATC CTATACTTTC CATGGCCGTG ATGTGTATGC TTACACTGGG 480

GCGCGCTTGG CTTCTGGGGC GATCACATTC GAGCAGGTCG GGCCAGAGCT TCCTATAAAA 540

GTTGTTGAAA TTCCTTACCA AAAAGCGAAA GCCACAAAAG GGGGAGTGAA AGGCAATATC 600

CCGATTTTGG ATATTCAATA TGGCAATGTT TGGAGCAATA TCAGCGATAA ACTGCTCAAT 660

CAAGCAGGGA TCAAACGAAA CGATACAGTG TGTGTAACTA TTTTTAAAAA TTCCAAGAAA 720

CAATACGAAG GGAAAATGCC GTATGTCGCG AGCTTTGGCG ATGTGCCAGA AGGCCAGCCG 780

TTGGTCTATT TAAACAGCTT GTTGAATGTT TCCGTGGCGT TGAATATGGA TAATTTCGCG 840

CAAAAACATC AAATTAAATC TGGTGCTGAC TGGAATATTG ATATAAAGAA GTGCGCTAAA 900

TAA 903 (2) INFORMATION FOR SEQ ID NO: 988:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1581 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...1581

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 988:

ATGAAACTTT TTAACCCTCG TTTAATCGTT TTTATATTCG CGCTTCTTTT AGGGGTAGGG 60

TTTTCTGTGC CTTCTTTGCT AGAAACTAAA GGCCCTAAAA TCACTTTAGG TTTGGATTTA 120

AGGGGGGGGT TGAACATGCT TTTAGGGGTG CAAACCGATG AGGCTTTAAA AAACAAGTAT 180

TTAAGCCTAG CGTCTGCTTT AGAATACAAC GCTAAAAAGC AAAATATCTT GCTTAAAGAC 240

ATTAAATCCA GTTTAGAGGG GATCAGTTTT GAGCTTTTAG ATGAAGATGA GGCGAAAAAA 300

TTAGACGCGC TTTTATTGGA ATTGCAAGGT CATAGCCAGT TTGAAATCAA AAAAGAAGCG 360

GAGTTTTATA GCGTGAAACT CACCCCTTTA GAGCAAGAGG AATTGCGTAA AAACACGATC 420

TTGCAAGTGA TAGGGATCAT TCGTAACCGC TTGGATCAAT TTGGTTTGGC AGAGCCTGTA 480

GTCATTCAGC AAGGCCGAGA AGAAATTTCG GTGCAATTGC CCGGCATTAA GACTTTAGAA 540

GAAGAGCGGC GCGCTAAAGA CTTGATTTCT AAATCCGCTC ATTTGCAGAT GATGGCAGTG 600

GATGAAGAAC ACAATAAAGA TGCGATGAAT ATGACGGATT TAGAGGCTCA AAAATTAGGC 660

AGCGTGTTGT TGTCTGATGC GGAAATGGGG GGTAAAATCT TACTCAAAGC GATCCCTATT 720

TTAGATGGCG AAATGCTTAC AGATGCGAAA GTGGTGTATG ATCAAAATAA CCAGCCGGTG 780

GTGAGCTTCA CGCTAGATGC GCAAGGGGCT AAGATTTTTG GGGATTTTTC AGGCGCGAAT 840

GTGGGCAAAC GCATGGCGAT CGTTTTAGAC AATAAGGTCT ATTCAGCCCC GGTGATTAGG 900

GAACGCATTG GTGGGGGGAG CGGGCAGATT AACGGGAATT TTAGCGTGGC TCAAGCGAGC 960

GATTTAGCGA TCGCTTTAAG GAGTGGGGCG ATGAACGCGC CCATTCAGGT TTTAGAAAAA 1020

AGGATTGTAG GTCCGAGTTT AGGGAAAGAC AGCATTAAAA CTTCCATTAT CGCTCTAGTT 1080

GGAGGCTTTA TTTTAGTGAT GGGCTTTATG GCACTTTATT ACTCCATGGC TGGGGTGATC 1140

GCTTGCATGG CGTTAGTGGT CAATCTTTTT TTGATCGTGG CGGTCATGGC GATTTTTGGA 1200

GCGACGCTGA CTTTACCGGG AATGGCAGGG ATTGTTTTAA CCGTGGGGAT TGCCGTGGAT 1260

GCTAATATCA TTATCAACGA ACGCATTAGA GAAGTTTTAA GAGAAGGAGA GGGTGTTGTT 1320

AAGGCGATCC ATTTAGGCTA TATCAATGCG AGCCGGGCGA TTTTTGACTC CAATATCACT 1380

TCCTTGATCG CTTCGGTGTT GCTATACGCT TATGGCACAG GAGCGATTAA AGGCTTTGCC 1440

CTCACCACAG GCATTGGGAT TTTAGCCTCT ATCATCACCG CTATTATAGG CACGCAAGGG 1500

ATTTATCAAG CCCTTTTACC TAAATTAGCC CAAACGAAAA GCCTTTACTT TTGGTTTGGC 1560

GTGAAAAATA AAAGAGCTTA G 1581

(2) INFORMATION FOR SEQ ID NO: 989:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2382 base pairs

(B) TYPE: nucleic acid (C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL : NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...2382

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 989:

ATAATGAATG GTTATTTGAG GGTAAAAACC CCGTATTTTT TAGCGTCGGT CGTTTTGACT 60

TTTTGGACTT TTAATTCTTT TATGAGCGCG AAAGATAAGC ACCATTTTTT AAAAAAAGTT 120

ACAACCACCG AGCAAAAATT CAGTTCTAGT GCCCCAATTT CATGGCAAAG CGAAGAGGTG 180

CGTAATTCCA CAAGCTCTCG CACGGTGATT TCCAACAAAG AACTCAAAAA AACGGGGAAT 240

TTGAATATTG AAAACGCCTT GCAAAATGTG CCAGGGATTC AAATCAGAGA CGCTACAGGC 300

ACGGGCGTGC TGCCTAAAAT TTCGGTGCGC GGTTTTGGTG GGGGCGGTAA CGGGCATAGC 360

AACACCAACA TGATTTTAGT CAATGGTATC CCCATTTATG GCGCGCCGTA TTCCAATATT 420

GAACTGGCGA TTTTCCCTGT AACTTTCCAG TCAGTGGATA GGATTGATGT GATTAAGGGG 480

GGAACGAGCG TCCAATACGG CCCTAACACT TTTGGAGGCG TGGTGAATGT CATCACTAAA 540

GAAATCCCCA AAGAGTGGGA AAATCAAGCG GCTGAAAGGA TCACTTTTTG GGGGCGCTCC 600

TCTAATGGGA ATTTTGTCGA TCCCAAAGAA AAAGGCAAGC CCTTAGCCCA AACTTTAGGA 660

AACCAAATGC TGTTTAACAC TTATGGGCGA ACGGCTGGGA TGTTGGGTAA ATATATAGGC 720

ATTAGCGCTC AAGGCAATTG GATTAATGGG CAAGGTTTCA GGCAAAATAG CCCTACAAAG 780

GTGCAAAACT ACTTGTTGGA TGCGATTTAT AAGATCAATG CGACCAATAC TTTTAAAGCT 840

TATTACCAGT ATTATCAATA CAACTCTTAC CATCCAGGCA CTTTGAGCGC GCAAGATTAC 900

GCCTATAACC GCTTCATCAA TGAGCGCCCT GACAATCAAG ATGGAGGGCG AGCCAAGCGC 960

TTTGGGATCG TGTATCAAAA CTACTTTGGC GATCCGGATA GGAAAGTGGG GGGCGATTTT 1020

AAATTCACTT ATTTCACGCA TGACATGAGT AGGGATTTTG GGTTTTCCAA CCAATACCAA 1080

AGCGTGTATA TGAGCGGTCA AAATAAGATT TTACCCTTTA AAGGCAAGGG AGAAATCAGC 1140

GCAAAAAACC CTAATTGCGG TCTGTATTCT TATAGCGACA CGAATAGCCC TTGCTGGCAA 1200

TTTTTTGACA ATATCCGCCG ATCCGTGGTG AATGCCTTTG AGCCAAAACT CAATCTTATC 1260

GTCAATACTG GTAAAGTCAA ACAAACTTTT AACATGGGAA TGCGCTTTTT AACTGAAGAT 1320

TTATACCGCC GATCCACCAC CAGGAAAAAC CCTAGCATGC CTAATAATGG GAGTGGGTTT 1380

GATGCAGGAA CTTCACTCAA TAATTTCAAC AATTATACCG CTGTGTATGC CAGCGATGAA 1440

ATCAATTTCA ATAACGGCAT GCTAACGATC ACGCCGGGCT TGAGATACAC TTTTTTAAAT 1500

TACGAAAAAA AAGACGCTCC TCCCTTTAAG GTGGGTCAAA CCCCAAAAAC CACGAAAGAG 1560

CGTTATAACC AATGGAATCC GGCAGTCAAT GTCGGCTATA AACCCATTAA AGAATTATTG 1620

TTTTATTTCA ATTACCAAAG AAGCTACATT CCGCCCCAAT TCAGCAATAT CGGTAATTTT 1680

GTAGGCACAA GCACGGATTA TTTTCAAATC TTTAATGTCA TGGAAGGCGG CTCAAGATAT 1740

TATTTTAACC ATCAAGTGAG TTTTAACGCG AACTATTTTG TGATTTTTGC GAATCATTAT 1800

TTTACCGGGC GCTATGGGGA CAACAGAGAG CCGGTCAATG CGAGATCGCA AGGCGTGGAG 1860

CTGGAACTCT ACTACACGCC TATTAGGGGG CTTAATTTCC ATGCGGCTTA CACTTTTATA 1920

GACGCTAATA TCACAAGCCA CACGATGGTT ACTAACCCTG CTAATCCTAA AGGGCCTAAA 1980

AAAGATATTT TTGGCAAAAA GCTCCCTTTT GTCAGCCCGC ACCAATTCAT TTTAGACGCG 2040

AGTTACACTT ACGCTAAAAC CACGATTGGG TTAAGCTCTT TCTTTTATAG CCGCGCTTAT 2100

AGCGATGTGT TAAACACCGT GCCTTTTACA GAATACGCGC CCACGATTAA AAATGGGGCT 2160

ATCGTTACCA AAACAGCGGG CATGACGCCG TACTATTGGG TGTGGAATTT GCAAATTTCT 2220

ACCACTTTGT GGGAACGCAA AAATCAAAGC GTGAATGCGA GCTTGCAAAT CAATAACATT 2280

TTTAACATGA AATATTGGTT TAGCGGGATA GGCACTAGCC CTAACGGGAA AGAAGCTGCG 2340 CCTCCCAGGA GCATCACAGC GTATGTGAGT TATAATTTTT AA 2382

(2) INFORMATION FOR SEQ ID NO: 990:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1002 base pairs (3) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...1002

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 990:

ATGCTAATCG CTCGCTTTAA AAAAGCTTTA ATTTCCTATT CTTTAGGGGT TCTTCTTGTT 60

TCATCGTTAT TAGGCGTGGC TAACGCTTCT AATCAAGAGA TCCAAGTCAA GGATTATTTT 120

GGGGAGCAAA CCATAAAGCT TCCTGTTTCT AAAATAATCT ACTTGGGCAG CTTTGCAGAA 180

GTGCCTGCCA TGTTCAATAC TTGGGATAGG GTCGTGGGCA TTTCGGATTA CGCTTTTAAA 240

TCTGATATTG TTAAAGCCAC TCTCAAAGAT CCTGAACGCA TTAAACCCAT GAGCAGTGAT 300

CATGTGGCGG CGTTGAATGT GGAATTATTA AAAAAGCTTA GCCCTGATCT TGTGGTAACC 360

TTTGTGGGTA ACCCTAAAGC GGTAGAGCAT GCGAAAAAAT TTGGGATTTC ATTCCTTTCT 420

TTCCAAGAAA AAACCATTGT AGAGGTCATG GAAGATATTG ACGCTCAAGC TAAGGCCTTA 480

GAAGTTGACG CTTCTAAAAA ATTGGCTAAA ATGCAAGAAA CTTTGGATTT TATCAAAGAG 540

CGTTTGAAAA ATGTCAAAAA GAAAAAGGGG GTGGAGCTTT TCCATAAAGC CAATAAAATC 600

AGCGGCCATC AAGCCCTTGA TTCAGATATT TTAGAAAAAG GGGGCATAGA CAATTTTGGC 660

TTGAAATACG TCAAGTTTGG GCGCGCTGAC ATTAGTGTGG AAAAAATCGT TAAAGAAAAC 720

CCTGAGATTA TTTTTATTTG GTGGATAAGC CCGCTTAGCC CTGAAGACGT GTTGAACAAC 780

CCTAAATTTT CCACTATCAA AGCCATTAAA AACAAGCAAG TCTATAAGCT CCCCACAATG 840

GATATTGGCG GACCTAGAGC CCCACTCATT AGTCTTTTTA TCGCTTTAAA AGCCCACCCT 900

GAAGCGTTTA AGGGCGTGGA TATTAATGCG ATAATCAAAG ATTACTATAA AGTGGTCTTT 960

GATTTGAATG ACGCGGAAGT TGAACCCTTT TTGTGGCACT GA 1002

(2) INFORMATION FOR SEQ ID NO: 991:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1203 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...1203

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:991:

ATGTATAAAT TAGGAATATT TTTATTAGCC ACCTTACTAT CAGCTAACAC GCAAAAAGTG 60

AGCGATATTG CTAAAGACAT CCAACATAAA GAAACCCTTT TGAAAAAAAC CCATGAAGAA 120

AAAAACCAAC TGAACAGTCG TTTGAGTTCT TTAGGCGAAG CGATCCGCTC TAAAGAGCTT 180

CAAAAGGTTG AGATTGAACG CCAAATGGTC GCCTTAAAAA AGAGTCTTGA AAAAAATCGT 240

AACGAAAGTT TGGTGCAAGA AAAAGTCCTA ACCAACTACC GCAAGTCTTT AGATCATTTG 300

CAAAAACAAC GATCGTTTTT ACAAAAGAGA GTGTTTGATA CGCTTTTAGA GGATTTTCTT 360

TTCTCACAAG CCCTAAAGGG GCAGAATTTA GCCTCTTCTA ATGATGTGAT TTTGCAAGTG 420

GCGTTTGAAA ACTTGCACCA AAGCACCCTG TCTAAAATGT CGCAACTGAG CCAAGAAGAA 480

AAGAAGCTCA ATGTGCAAGC TTTAGAAGTC AAAAGCAGCA TTCAAAAAAT CTCCTCTGTC 540

ATAGATGAGC AAAAAACTCG TGAATCAACC TTAAAATCCT TGCAAACCGA ACAAAATAAG 600

CTCATTTTGA GCATGCAAAA AGATTATGCG ATCTATAACC AACGGCTATC CCTTTTAGAA 660

AAAGAACGCC AGAATTTAAA CGCTCTTTTA AAACGCTTGA ATATCATCAA ACAAAATAGG 720

GAAAATGAAG AGAGGGTCAG TTTGAAAAAA TCTTCTCAAG CTTTAGAAGT CAAACAAGTG 780

GCTAGCTCTT ATCAAAATAT CAACACCACG AGCTATAACG GGCCAAAAAC GATCGCTCCC 840

TTGAACGATT ACGAAGTGGT GCAAAAATTT GGCCCCTATA TTGACCCGGT TTATAATTTA 900

AAAATTTTTA GCGAGTCTAT CACGCTAGTG TCAAAAACCC CAAACGCTTT GGTGCGTAAT 960

GTTTTAGACG GGAAAATCGT GTTCGCTAAA GAAATCAACA TGCTTAAAAA AGTCGTTATC 1020

ATTGAGCATA AAAACGGGAT CCGCACGATT TATTCTCAAT TGGATAAAAT CGCCCCCACC 1080

ATTAAAAGCG GCATGCGGAT CCAAAAAGGC TATGTTTTAG GACGCATTGA TCAACGCTTG 1140

GGCTTTGAAG TTACCATGAG AGAAAAGCAC ATTAACCCCT TAGAACTCAT CGCGCGCAAT 1200

TAA 1203

(2) INFORMATION FOR SEQ ID NO: 992:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1650 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...1650

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 992:

ATGGATAAAA ACAACAATAA TAATCTCCGC TTGATTTTAG CGATCGCTCT GTCTTTCTTG 60 TTTATCGCTC TTTATAGCTA TTTTTTCCAA GAACCAAACA AAACAACAAC CGAAACCACA 120 AAGCAAGAAA CAACCAACAA CCACACAGCA ACAAGCCCCA CCGCGTCCAA TACCATCACC 180 CAAGATTTTA GCGTTACCCA AACCATCCCT CAAGAGAGTT TGTTAAGCAC GATTTCTTTT 240

GAACATGCCA AAATTGAAAT TGATTCTTTA GGGCGCATCA AACAGGTTTA TCTCAAAGAT 300

AAAAAGTATC TAACCCCTAA AGAAAAGGGC TTTTTAGAGC ATGTGAGCCA TCTTTTTAGC 360

TCCAAAGAAA ACTCGCAACC CTCCCTAAAA GAGCTCCCCC TTTTAGCAGC CGATAAACTC 420

AAGCCTTTAG AAGTGCGTTT TTTAGACCCC ACGCTCAATA ATAAAGCGTT CAACACCCCT 480

TATAGCGCCT CAAAAACCAC CCTTGGGCCT AACGAACAGC TCGTTTTAAC CCAAGATTTA 540

GGCACTCTTA GCATCATTAA AACCCTGACT TTTTATGATG ATTTGCATTA TGATTTAAAA 600

ATCGCATTCA AATCGCCCAA TAACCTTATC CCTAGCTATG TGATCACCAA TGGTTACAGG 660

CCGGTGGCTG ATTTAGACAG CTACACCTTT TCAGGCGTGC TTTTAGAAAA CACCGACAAA 720

AAAATTGAAA AAATTGAAGA TAAAGACGCT AAAGAAATCA AACGCTTTTC TAACACCCTC 780

TTTTTATCCA GCGTGGATAG GTATTTCACT ACTTTGCTTT TCACTAAAGA TCCTCAAGGT 840

TTTGAAGCCT TAATTGATTC AGAAATAGGG ACTAAAAACC CCTTAGGGTT CATTTCCCTT 900 AAAAACGAAG CGAATTTGCA TGGCTATATT GGCCCTAAAG ATTACCGCTC TTTGAAAGCG 960

ATTTCACCCA TGCTCACTGA TGTGATAGAG TATGGCTTGA TCACTTTCTT TGCCAAAGGC 1020

GTGTTTGTTT TACTGGATTA TTTGTATCAA TTTGTGGGCA ATTGGGGTTG GGCTATCATT 1080

CTTTTAACGA TTATCGTGCG CATTATCCTC TACCCCTTAA GCTATAAGGG CATGGTGAGC 1140

ATGCAAAAGC TCAAAGAATT AGCCCCTAAA ATGAAAGAAC TCCAAGAAAA ATACAAGGGC 1200

GAACCCCAAA AGTTACAAGC CCACATGATG CAGCTTTACA AAAAACATGG GGCTAACCCG 1260

CTAGGGGGTT GTTTGCCCTT AATCTTACAA ATCCCAGTAT TTTTTGCGAT TTATAGAGTG 1320

CTTTATAACG CTGTGGAATT GAAAAGCTCA GAGTGGGTTT TATGGATCCA TGATTTATCC 1380

ATCATGGATC CGTATTTCAT TTTACCGCTT CTTATGGGAG CGTCTATGTA TTGGCACCAG 1440

AGCGTTACGC CAAACACCAT GACCGATCCC ATGCAAGCAA AGATTTTTAA ACTCTTGCCC 1500

CTATTATTCA CGATCTTTCT AATCACTTTC CCTGCAGGGT TAGTCTTGTA TTGGACCACA 1560

CACAACATCC TTTCGGTGTT GCAGCAACTC ATCATTAATA AAGTCTTAGA GAATAAAAAA 1620

CGCGCGCACG CTCAAAACAT AAAGGAATAA 1650

(2) INFORMATION FOR SEQ ID NO: 993:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1440 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...1440

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 993:

ATGAAAAAAT CCCTTTGTTT GTCTTTCTTT CTGACCTTCT CTAACCCTCT TCAAGCCCTT 60 GTCATTGAGC TTTTAGAAGA GATTAAAACT TCGCCGCATA AAGGCACTTT TAAGGCTAAA 120 GTCCTTGATT CTAAAGAACC AAGACAAGTT TTAGGCGTTT ATAATATCTC CCCACACAAA 180 AAACTCACGC TCACTATCAC TCACATATCC ACGGCAATCG TCTATCAACC CCTTGATGAA 240 AAACTTTCTT TAGAAACGAC CTTAAGCCCT AACCGCCCTA CTATCCCTAG AAACACCCAA 300 ATCGTTTTTT CTTCAAAAGA ATTGAAAGAA^' CCGCACTCAA ACCCAATACC TTCTTTAAAC 360 GCGCCCATGC AAAAACCACA AAATAAACCC AGCTCATCGC AACAATCTCC TCAAAACTTT 420 TCTTACCCAG AGTCCAAACT AGGCTCTAAA AACTCTAAAA ACAGCCTTTT ACAGCCTTTA 480 GTAACTCCTA GCAAAGTAAG CCCCACTAAC GAAGTTAAAA CGCCAACAAA CGACGCTAAT 540

CCCCCTTTAA AGCATTCTTC ACAAGATCAA GAAAACAACC TCTTTGTAGC GCCACCCACT 600

GAAAAAACGC TCCCTAACAA CACCTCTAGT GCTGATGCGA GTGAAAACAA TGAAAGCAAC 660

GAAAATAGGG ATAATGTGGA AAAACAAGCG ATTAGAGATC CTAATATCAA AGAATTCGCA 720

TGCGGGAAGT GGGTTTATGA TGATGAAAAT TTACAAGCCT ATCGCCCAAG CATTTTAAAA 780

CGCGTTGATA AAGACAAAGA GATTACAACA GACATTACCC CTTGCGATTA CAGCACCGCT 840

GAAAATAAAA GCGGTAAAAT CATTACCCCC TATACTAAAA TCTCTGTTCA TAAAACAGAG 900

CCTTTAGAAG ACCCTCAAAC TTTTGAAGCT AAAAATAATT TCGCCATTCT CCAAGCCAGA 960

AGCTCTACAG AAAAGTGTAA AAGGGCTAGA GCGAGAAAAG ACGGCACGAC CAGGCAATGC 1020

TATCTGATAG AAGAGCCTTT AAAACAAGCG TGGGAGAGCG AGTATGAAAT CACCACGCAA 1080

TTAGTGAAAG CCATATATGA ACGCCCCAAA CAAGACGATC AAGTAGAGCC GACTTTTTAT 1140

GAAACCAGCG AATTGGCTTA TTCTTCCACA CGAAAAAGCG AAATAACGCG TAATGAATTG 1200

AATTTGAATG AAAAATTCAT GGAATTTGTG GAAGTGTATG AGGGGCATTA TTTAAACGAT 1260

ATAATCAAAG AGAGCAGCGA ATACAAAGAA TGGGTTAAAA ACCATGTGCG CTTTAAAGAA 1320

GGGGTGTGCA TGGCCTTAGA AATAGAAGAG CAACCACGAG CCAAAAGCAC GCCTTTGAGT 1380

ATTGAAAACT CTCGTGTTGT GTGTGTCAAA AAGGGGAATT ATTTATTCAA TGAAGTTTAA 1440

(2) INFORMATION FOR SEQ ID NO: 994:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 810 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 810

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 994:

GTGAAAGTTT ATCCGCAAGT TTTAAGCATT GCTGGTAGCG ATAGCGGTGG GGGCGCTGGG 60

ATACAGGCCG ATTTGAAAGC GTTTCAAACT TTTGGCGTGT TTGGGACAAG CGTGATCACT 120

TGCATCACCG CTCAAAACAC ACAGGGCGTG CATGGGGTGT ATCCATTGAG TGTAGAGAGC 180

GTGAAAGCGC AAATCCTAGC TATTAGAGAT GATTTTTCGA TCAAGGCGTT CAAAATGGGG 240

GCGTTATGCA ACGCTCAAAT CATTGAATGC GTAGCGAACG CTTTAGAAAC TTGTGATTTT 300

GGGTTGTGCG TTTTAGATCC GGTGATGGTG GCAAAGAATG GGGCTTTGCT TTTAGAAGAG 360

GAGGCGATTT TAAGCTTAAA AAAACGCCTT TTACCTAAAA CCAATTTACT AACCCCTAAC 420

CTCCCTGAAG TCTATGCGCT CACAGGCGTT CAAGCGCGAG ACGATAAAAG CGCTTCAAAA 480

GCGATGGGTG TTTTAAGGGA TTTAGGCGTT AAAAACGCTG TGATTAAAGG GGGGCATACA 540

GAACATTTTC AAGGGGAATT TAGCAACGAT TGGGTGTTTT TAGAAGACGC TGAATTTATC 600

TTAAGCGCCA AGCGATTCAA CACCAAAAAC ACGCATGGCA CGGGTTGTAC TTTGTCTAGC 660

TTGATTGTGG GCTTACTCGC TCAAGGGCTG GATTTAAAAA ACGCTATCAC AAAGGCTAAA 720

GAGCTTTTAA CTATCATCAT TCAAAACCCC TTAAACATTG GGCATGGGCA TGGGCCTTTG 780

AATTTGTGGA GCATCAAAAA GCATGTTTGA 810

(2) INFORMATION FOR SEQ ID NO: 995: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH. 1197 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS. double

(D) TOPOLOGY, circular

(n) MOLECULE TYPE- DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...1197

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 995:

TTGGGGGCTA TCATGGATAC TTTTTTAACA AGTATCTTGG TCCTGCTTAT GCGGGGACTT 60

CTCAATCAGC GAGCTATCAT GCAAGGCCTT ATGTGGTGGA TACCGCTTTT TTACGATACG 120

ATTACCAAAG ATGTTTTTGG GTTTAAGGCG GGGCGCTATG AAGCGAATAT TGATTTCATG 180

AGCGGTTCGA ATCAAGGGTG GGAAGTGTAT TATCAGCCCT ATAAGACTGA GACGCAAAGG 240

TTAAGGTTTT GGTGGTGGAG TTCTTTTGGG AGAGGTTTGG CGTTTAACTC TTGGATTTAT 300

GAGTTTTTTG CGACCGTGCC TTATTTGAAA AAGGGAGGCA ACCCTAGTAA CAGCAACGAT 360

TTCATCAATT ATGGCTGGCA TGGGATCACC ACGACTTATT CTTATAAAGG TTTAGACGCT 420

CAATTTTTTT ATTATTTTGC ACCTAAAACT TATAACGCTC CCGGTTTTAA GCTAGTCTAT 480

GACACGAATA GGAATTTTGA AAACGTAGGC TTTCGCTCTC AAAGCATGAT CATGACGACC 540

TTCCCTTTAT ATTATAGGGG GTGGTATAAC CCAGAGACAA ACACTTATAG CTTAGAAGAC 600

AGCACGCCTC ATGGCTCTTT GTTAGGGAGG AATGGCGTTA CTTTAAATAT CCGCCAGGTT 660

TTTTGGTGGG ATAATTTCAA CTGGTCCATT GGCTTTTATA ACACCTTTGG CAATTCAGAC 720

GCTTTTTTAG GCTCTCACAC CATGCCAAGG GGGAATAACA CTTCCTATAT CAGTAATGAA 780

ATCTCAGTAA CGACTAGGCA TGCCGGAATG ATCGGCTATG ATTTTTGGGA TAATACGGCT 840

TATGATGGGC TGGCTGATGC GATCACTAAC GCGAACACTT TCACTTTTTA CACTTCGGTT 900

GGAGGGATCC ATAAGCGTTT TGCATGGCAT GTTTTTGGGC GCGTCTCTCA TGCGAATAAA 960

AATGCGTTAG GGCAAGTGGG GAGGGCTAAT GAATATTCCT TGCAATTCAA TGCGAGCTAT 1020

GCGTTCACTG AATCGGTTCT CCTTAACTTT AGGATCACTT ATTATGGGGC TAGGATCAAT 1080

AAAGGGTATC AAGCAGGGTA TTTTGGAGCG CCCAAATTCA ATAACCCGGA TGGCGATTTT 1140

AGCGCTAATT ACCAAGACAG AAGTTACATG ATGACCAACC TCACGCTGAA GTTTTGA 1197

(2) INFORMATION FOR SEQ ID NO: 996:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1335 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE: (A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...1335

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 996:

TTGAGTAACG CTTTCTCCCA ATACCTTTAT TCGCTTTTAG GGGCGTATCC CACGAAACTC 60

AATGGTAACG ACGTGTCTGC GAACGCTCTT TTAAGTGGTG CGGTAGGCAG TGGGACTTGC 120

GCGGCTGCAG GGACGGCTGG TGGCACAACT CTTAACACTC AAAGCGCTTG CACCGCTGCG 180

GGCTATTACT GGCTCCCTAG CTTGACTGAT AGGATTTTAA GCACGATCGG CAGCCAGACT 240

AACTACGGCA CGAACACCAA TTTCCCCAAC ATGCAACAAC AGCTCACCTA CTTGAATGCG 300

GGGAATGTGT TTTTTAATGC GATGAATAAG GCTTTAGAGA AGAATGGGAC TGCTACTGCT 360

AATAGCACTA GTAGCACTAG CGGTGCGACT GGTTCAGATG GTCAAACTTA CTCTCAACAA 420

GCTATTCAAT ACCTTCAAGG CCAACAAAAT ATCTTAAATA ACGCAGCGAA CTTGCTCAAG 480

CAAGATGAAT TGCTCCTAGA AGCTTTCAAC TCTGCCGTAG CTGCTAACAT TGGGAATAAG 540

GAATTCAATT CAGCCGCTTT TACAGGTTTG GTGCAAGGCA TTATTGATCA ATCTCAATTG 600

GTTTATAACG AGCTCACTAA AAACACCATT AGCGGGAGCG CGGTTAATAA CGCTGGGATA 660

AACTCCAACC AAGCTAACGC TGTGCAAGGG CGTGCTAGTC AGCTCCCTAA CGCTCTTTAT 720

AACGTGCAAG TAACTTTGGA TAAAATCAAC GCGCTCAACA ATCAGGTGAG AAGCATGCCT 780

TACTTGCCCC AATTCAGAGC CGGGAACAGC CGTGCAACGA ATATTTTAAA CGGGTTTTAC 840

ACTAAAGTGG GCTATAAGCA ATTCTTCGGG AAGAAAAGGA ATATCGGTTT GCGCTATTAT 900

GGTTTCTTTT CTTATAACGG AGCGAGCGTG GGCTTTAGAT CCACTCAAAA TAATGTAGGG 960

TTATACACTT ATGGGGTGGG GACTGATGTG TTGTATAACA TCTTTAGCCG CTCCTATCAA 1020

AACCGCTCTG TGGATATGGG CTTTTTTAGC GGTATCCAAT TAGCCGGTGA GACCTTCCAA 1080

TCCACGCTCA GAGATGACCC CAATGTGAAA TTGCATGGGA AAATCAATAA CACGCACTTC 1140

CAGTTCCTCT TTGACTTCGG TATGAGAATG AACTTCGGTA AGTTGGACGG GAAATCCAAC 1200

CGCCACAACC AGCACACGGT GGAATTTGGC GTAGTAGTGC CTACGATTTA TAACACTTAT 1260

TACAAATCAG CAGGGACTAC CGTGAAGTAT TTCCGTCCTT ATAGCGTTTA TTGGTCTTAT 1320

GGGTATTCAT TCTAA 1335

(2) INFORMATION FOR SEQ ID NO: 997:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 402 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...402

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 997:

ATGGAGTTAA TTAAGAAATT GGAAAAAGAA AGCGAAGTTT TAAAGAAAGA TTTACAACAA 60 CATTCAAACG AGCTTTTTAA AATGTTGATT ATTGATAATG AAGATTTGTT TAAAGAGCAA 120 TTTGAGATTA TGTTTAAAGC ATGGGTTGAA ATCGTAAAAA TGATGTTTGA ATTAACCAAA 180

AAAACCAAAT TTGATGGCGA AATGATTGGC TACACAGAAG AACTTTTAAC CTTTTTAGTT 240

AGAGATTTTT TTAATGGGAT TTTTAAATCC AAAGTAATAC CTAAAATGCC TATTTTTTGC 300

GGTGATGTTA AATGCGAAGA TTTTAATGCC CTAAGAAGTT TAGTTTATCT TTCTGTGCTT 360

GAGTTGGAAG AAACGATAAA TCCTAATAAA ATCCCATTTT AA 402

(2) INFORMATION FOR SEQ ID NO: 998:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2091 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...2091

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 998:

ATGAAAATCA AAAAATCCCT CTTTGCTCTC TCTTTCTCTC TCATGGCTTC ATTATCAAGG 60

GCTGAAGATG ACGGATTTTA CATGAGTGTG GGCTATCAAA TCGGTGAAGC GGTCCAAAAA 120

GTGAAAAACA CTGGAGCATT ACAAAATCTT GCAGACAGAT ACGATAACTT GAGCAACCTT 180

TTAAACCAAT ACAATTACTT AAATTCCTTA GTCAATCTAG CCAGCACGCC TAGCGCGATT 240

ACCGGTGCGA TTGACAATCT AAGCTCAAGC GCGATCAATC TCACTAGCGC TACCACCACT 300

TCTCCGGCCT ATCAAGCTGT GGCTTTAGCG CTCAATGCGG CTGTGGGCAT GTGGCAAGTC 360

ATAGCCTTTG GCATCAGCTG TGGCCCTGGC CCCAATCTTG GCCCAGAACA TTTAGAAAAT 420

GGGGGCGTTC GATCGTTTGA CAACACGCCA AACTACAGCT ACAACACCGG TAGCGGAACG 480

ACCACCACCA CTTGTAATGG AGCCAGTAAT GTAGGGCCCA ATGGTATCCT ATCTAGCAGC 540

GAATACCAGG TTCTCAATAC CGCTTATCAA ACTATCCAAA CCGCTTTAAA CCAAAACCAA 600

GGAGGCGGGA TGCCTGCCTT GAATAGCTCC AAAAATATGG TAGTCAATAT CAATCAAACT 660

TTCACAAAAA ACCCTACCAC AGAATACACT TACCCCGATG GGAATGGCAA TTATTATTCA 720

GGCGGTTCAT CAATCCCAAT CCAGCTAAAG ATTAGTAGCG TCAATGACGC TGAAAACCTT 780

TTGCAACAAG CCGCTACTAT CATCAATGTC CTTACCACCC AAAACCCGCA TGTGAATGGT 840

GGCGGTGGGG CATGGGGGTT TGGCGGTAAG ACCGGGAATG TGATGGATAT TTTTGGCGAT 900

AGTTTTAACG CTATTAACGA AATGATCAAA AACGCTCAAG CCGTTTTAGA AAAAACCCAA 960

CAGCTTAACG CTAATGAAAA CACCCAAATC ACGCAACCAG ACAATTTCAA CCCCTACACT 1020

TCTAAAGACA CGCAGTTCGC TCAAGAAATG CTCAATAGAG CTAACGCTCA AGCAGAGATT 1080

TTGAGCTTAG CCCAACAAGT AGCGGACAAT TTCCACAGCA TTCAAGGGCC TATCCAACAA 1140

GATCTAGAAG AATGCACCGC AGGATCAGCT GGTGTGATTA ACGACAACAC TTATGGTTCA 1200

GGTTGCGCGT TTGTGAAAGA GACTCTCAAT TCCTTAGAGC AACACACCGC TTATTATGGC 1260

AACCAGGTCA ATCAGGATAG GGCTTTGTCT CAAACCATTT TGAATTTTAA AGAAGCCCTT 1320

AGCACTTTAG GGAACGACTC AAAAGCGATC AATAGCGGTA TCTCTAACTT GCCTAACGCT 1380

AAGTCCCTTC AAAACATGAC GCATGCCACT CAAAACCCTA ATTCCCCAGA AGGTTTGCTC 1440

ACTTATTCTT TGGATACCAG CAAATACAAC CAGCTCCAAA CTGTTGCGCA AGAATTAGGC 1500

AAAAACCCCT TTAGGCGCAT CGGCGTGATT AACTATCAAA ACAATAACGG GGCGATGAAC 1560

GGCATCGGCG TGCAAGCGGG CTATAAGCAA TTCTTTGGCA AAAAAAGGAA TTGGGGGTTA 1620

AGGTATTATG GTTTCTTTGA TTATAACCAT GCTTATATCA AATCTAATTT TTTTAACTCG 1680 GCTTCTGATG TGTGGACTTA TGGGGTGGGT ATGGACGCGC TTTATAACTT CATCAACGAT 1740

AAAAACACCA ACTTTTTAGG CAAAAATAAC AAGCTTTCTG TGGGGCTTTT TGGTGGCTTT 1800

GCGTTAGCCG GGACTTCGTG GCTTAATTCC CAACAAGTGA ATTTGACCAT GATGAATGGC 1860

ATTTATAACG CTAATGTCAG CGCTTCTAAC TTCCAATTTT TGTTTGATTT AGGCTTGAGA 1920

ATGAACCTCG CTAGGCCCAA GAAAAAAGAC AGCGATCATG CCGCTCAGCA TGGCATGGAA 1980

TTGGGCGTGA AAATCCCCAC CATTAACACG GATTATTATT CTTTCATGGG GGCTGAACTC 2040

AAATACAGAA GGCTCTATAG CGTGTATCTC AATTATGTGT TTGCTTACTA G 2091

(2) INFORMATION FOR SEQ ID NO: 999:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1116 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...1116

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 999:

ATGCAATTTC AAAAAACCTT ATCTTCCTTA TCTTTATTTT TATCTTTATC TTTATTCTTA 60

TCTTTTAGTA TCGCTGAAGA AAATGGGGCG TATGCGAGCG TGGGTTTTGA ATATTCCATC 120

AGTCATGCCG TTGAACACAA TAACCCTTTT TTGAATCAAG AACGCATCCA AACGATTTCT 180

AACGCTCAAA ACAAAATCTA TAAACTCAAT CAAGTCAAAA ATGAAATCAC AAACATGCCC 240

AACACCTTTA ACTACATCAA CAACGCTTTA AAAAACAATG CTAAATTAAC CCCTACTGAA 300

AAGCAAGCCG AAACCTACTA CCTGCAATCT ACCCTTCAAA ACATTGAAAA AATAGTCATG 360

CTTAGCGGGG GCGTTGCGTC TAACCCTAAA TTAGCCCAAG CGTTAGAAAA AATGCAAGAA 420

CCCATTACTA ACCCTTTAGA ATTGGTAGAA AACTTAAAAA ATTTAGAATT ACAATTCAGC 480

CAATCTCAAA ACAGCATGCT TTCTTCTTTG TCTTCTCAGA TCGCTCAAAT TTCAAATTCT 540

TTGAACGCGC TTGATCCCAG CTCTTATTCT AAAAACGTTT CAAGCATGTA TGGGGTAGGT 600

TTGAGCGTAG GGTATAAGCA TTTCTTTACC AAGAAAAAAA ATCAAGGGTT TCGTTATTAC 660

TTATTCTATG ACTATGGTTA CACTAATTTT GGTTTTGTGG GTAATGGCTT TGATGGTTTA 720

GGCAAAATGA ATAACCACCT CTATGGGCTT GGCATAGATT ATCTTTTCAA TTTCATTGAT 780

AATGCGCAAA AACATTCGAG CGTGGGGTTT TATGTAGGCT TTGCTTTAGC GGGGAGTTCG 840

TGGGTAGGGA GTGGTTTAGG CATGTGGGTG AGTCAAATGG ATTTCATCAA CAACTATTTG 900

ACGGATTATC GGGCTAAAAT GCACACGAGT TTTTTCCAAA TCCCTTTGAA TTTTGGGGTT 960

CGTGTGAATG TGGATAGGCA CAATGGCTTT GAAATGGGCT TAAAGATCCC TTTAGCGGTC 1020

AATTCCTTTT ATGAAACGCA TGGCAAAGGG TTAAACGCTT CCCTCTTTTT CAAACGCCTT 1080

GTCATGTTTA ACGTGAGTTA TGTTTATAGT TTTTAG 1116

(2) INFORMATION FOR SEQ ID NO: 1000:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1455 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double (D) TOPOLOGY: circular

(11) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI -SENSE- NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...1455

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1000:

ATGGCTAAAA TCACAACCGT GATTGACATA GGCTCTAATT CAGTGCGTTT GGCTGTCTTT 60

AAAAAGACGA GCCAGTTTGG GTTTTACTTG CTTTTTGAGA CTAAGTCCAA GGTTAGGATT 120

TCAGAGGGCT GTTATGCGTT TAAAGGGGTT TTACAAGAAA TCCCCATGCA ACGAGCCGTT 180

AAAGCCTTGA GCGAATTTAA AGAAATCGCC CTCAAATACA AAAGCAAAAA AATCCTGTGC 240

GTGGCGACCT CAGCGGTGCG CGATGCCCCT AATCGGTTAG AGTTTGTAGC GAGGGTGAAA 300

AAGGCTTGCG GTTTGCAAAT CAAAATCATT GATGGGCAAA AAGAAGCGCT CTATGGTGGG 360

ATCGCGTGCG CGAATTTGCT GCATAAAAAT TCAGGGATCA CGATAGACAT TGGAGGGGGT 420

AGCACCGAGT GCGCGTTGAT TGAGAAAGGT AAGATTAAGG ACTTAATCTC GCTTGATGTC 480

GGGACGATTC GCATTAAAGA AATGTTTCTA GACAAAGACT TAGATGTCAA ATTGGCTAAA 540

GCCTTTATCC AAAAAGAGGT CTCTAAACTG CCTTTTAAGC ATAAAAACGC CTTTGGGGTG 600

GGGGGGACGA TCAGAGCCTT GAGTAAGGTG CTGATGAAAC GCTTTGATTA CCCTATAGAT 660

TCTTTGCATG GCTATGAAAT AGATGCGCAT AAAAATTTAG CGTTCATTGA AAAAATCGTC 720

ATGCTCAAAG AAGACAAATT ACGGCTTTTA GGGGTGAATG AAGAGCGTTT GGATAGCATT 780

AGGAGCGGGG CGTTGATTTT ATCAGTCGTG TTAGAGCATT TGAAAACTTC CTTGATGATC 840

ACTAGCGGGG TAGGGGTGAG AGAGGGCGTG TTTTTGAGCG ATTTATTGCG CCACCATTAC 900

CATAAATTCC CCCCCAATAT CAACCCCTCT CTCATCTCTC TAAAAGATCG CTTTTTACCC 960

CATGAAAAGC ACAGCCAAAA GGTCAAAAAA GAATGCGTGA AATTGTTTGA AGTTTTATCG 1020

CCTTTGCATA AAATAGATGA AAAATACCTT TTCCATTTAA AGATTGCGGG GGAATTGGCG 1080

AGCATGGGTA AGATTTTAAG TGTATATTTA GCCCACAAGC ACAGCGCGTA TTTCATTTTA 1140

AACGCTTTGA GTTACGGCTT TAGCCACCAG GATAGGGCGA TCATTTGCTT ATTGGCGCAA 1200

TTTAGCCATA AAAAAATCCC TAAAGACAAC GCTATCGCCC ACATGAGTGC GATGATGCCA 1260

AGCCTTTTGA CCTTGCAGTG GCTGAGTTTT ATCCTTTCTT TAGCCGAAAA TTTGTGCCTG 1320

ACAGACAGCC ATCATTTAAA ATACACGCTA GAAAAAAACA AGCTTGTGAT CCATTCTAAT 1380

GATGCGCTTT ACTTGGCTAA AGAAATGCTC CCCAAACTCA TTAAGCCCAT TCCTTTGACG 1440

ATAGAGTTTG CTTGA 1455

(2) INFORMATION FOR SEQ ID NO: 1001:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 762 base pairs

(B) TYPE- nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic) (ill) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME / KEY : mi s cjeature

( B ) LOCATION 1 . . . 762

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1001:

AAACAGGTTA AATCTCGCAT GAAAGAAAAG CCGTTCAATA GCGAGCAGAT GGCTTTTTTA 60

GAAGAGCTTT TAAGCCACCA AGAAAAGCAT TTAGAGAGCA AGCTTTCTGG TTTTTCGGTG 120

AATGATTTGG ACATGCAAAG CGTGTTTCGG CTAGAAAGGA ACCGCTTGAA AATCGCTTAC 180

AGGCTTTTAG GTTTGATGAG CTTTATCGCG CTTGTCTTAG CGATCGTTTT AATCAGTATC 240

CTGCCCTTAC AAAAAACCGA ACACCATTTC GTGGATTTTT TAAACCAGGA CAAGCATTAC 300

GCCATTATCC AAAGAGCGGA TAAAAGCATT TCCAGTAATG AAGCGTTGGC TCGTTCGCTC 360

ATTGGGGCGT ATGTGTTAAA CCGAGAGAGC ATTAATCGCA TTGACGATAA ATCCCGCTAT 420

GAACTGGTGC GCTTGCAAAG CAGCTCTAAA GTGTGGCAAC GCTTTGAAGA TTTGATTAAA 480

GCCCAAAACA GCATCTATGT GCAAAGCCAT TTAGAAAGAG AAGTCCATAT CGTCAATATT 540

GCGATCTATC AGCAAGACAA TAACCCCATT GCGAGCGTGT CCATTGCGGC TAAACTTTTG 600

AATGAAAACA AGCTCGTGTA TGAAAAGCGT TATAAAATCG TATTGAGCTA TTTGTTTGAC 660

ACCCCGGATT TTGATTACGC TTCCATGCCT AAAAACCCTA CCGGCTTTAA AATCACTCGC 720

TACAGCATCA CTGAAATCGC GCCGACTAAT AGGAATGATT GA 762

(2) INFORMATION FOR SEQ ID NO: 1002:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1440 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...1440

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1002:

ATGAAAAAAT CCCTTTGTTT GTCTTTCTTT CTGACCTTCT CTAACCCTCT TCAAGCCCTT 60

GTCATTGAGC TTTTAGAAGA GATTAAAACT TCGCCGCATA AAGGCACTTT TAAGGCTAAA 120

GTCCTTGATT CTAAAGAACC AAGACAAGTT TTAGGCGTTT ATAATATCTC CCCACACAAA 180

AAACTCACGC TCACTATCAC TCACATATCC ACGGCAATCG TCTATCAACC CCTTGATGAA 240

AAACTTTCTT TAGAAACGAC CTTAAGCCCT AACCGCCCTA CTATCCCTAG AAACACCCAA 300

ATCGTTTTTT CTTCAAAAGA ATTGAAAGAA CCGCACTCAA ACCCAATACC TTCTTTAAAC 360

GCGCCCATGC AAAAACCACA AAATAAACCC AGCTCATCGC AACAATCTCC TCAAAACTTT 420

TCTTACCCAG AGTCCAAACT AGGCTCTAAA AACTCTAAAA ACAGCCTTTT ACAGCCTTTA 480

GTAACTCCTA GCAAAGTAAG CCCCACTAAC GAAGTTAAAA CGCCAACAAA CGACGCTAAT 540

CCCCCTTTAA AGCATTCTTC ACAAGATCAA GAAAACAACC TCTTTGTAGC GCCACCCACT 600

GAAAAAACGC TCCCTAACAA CACCTCTAGT GCTGATGCGA GTGAAAACAA TGAAAGCAAC 660 GAAAATAGGG ATAATGTGGA AAAACAAGCG ATTAGAGATC CTAATATCAA AGAATTCGCA 720

TGCGGGAAGT GGGTTTATGA TGATGAAAAT TTACAAGCCT ATCGCCCAAG CATTTTAAAA 780

CGCGTTGATA AAGACAAAGA GATTACAACA GACATTACCC CTTGCGATTA CAGCACCGCT 840

GAAAATAAAA GCGGTAAAAT CATTACCCCC TATACTAAAA TCTCTGTTCA TAAAACAGAG 900

CCTTTAGAAG ACCCTCAAAC TTTTGAAGCT AAAAATAATT TCGCCATTCT CCAAGCCAGA 960

AGCTCTACAG AAAAGTGTAA AAGGGCTAGA GCGAGAAAAG ACGGCACGAC CAGGCAATGC 1020

TATCTGATAG AAGAGCCTTT AAAACAAGCG TGGGAGAGCG AGTATGAAAT CACCACGCAA 1080

TTAGTGAAAG CCATATATGA ACGCCCCAAA CAAGACGATC AAGTAGAGCC GACTTTTTAT 1140

GAAACCAGCG AATTGGCTTA TTCTTCCACA CGAAAAAGCG AAATAACGCG TAATGAATTG 1200

AATTTGAATG AAAAATTCAT GGAATTTGTG GAAGTGTATG AGGGGCATTA TTTAAACGAT 1260

ATAATCAAAG AGAGCAGCGA ATACAAAGAA TGGGTTAAAA ACCATGTGCG CTTTAAAGAA 1320

GGGGTGTGCA TGGCCTTAGA AATAGAAGAG CAACCACGAG CCAAAAGCAC GCCTTTGAGT 1380

ATTGAAAACT CTCGTGTTGT GTGTGTCAAA AAGGGGAATT ATTTATTCAA TGAAGTTTAA 1440

(2) INFORMATION FOR SEQ ID NO: 1003:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1704 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...1704

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1003:

ATGATTTTTG GGGATTTTAA ATATCAAAAA AGCGTTAAAA AACTCACAGC CACTAACCTT 60

AACGAGCTTA AAAACGCCCT GGATTTTATC TCTCAAAATA GGGGGAAGGG GTATTTTGTG 120

GGGTATCTTT TGTATGAAGC GCGCTTAGCG TTTTTAGATG AAAATTTTCA AAGCCAAACC 180

CCTTTTTTGT ATTTTGAACA ATTTTTAGAA AGAAAAAAAT ACCCTTTAGA GCCTTTAAAA 240

GAGCATGCGT TTTACCCTAA AATCCACAGC TCTTTAGATC AAAAAACTTA TTTCAAGCAG 300

TTTAAGGCCG TTAAAGAGCA TCTCAAAAAC GGCGATACCT ATCAAGTGAA TTTGACAATG 360

GATTTATTGT TAAACACTAA AGCCAAACCA AAGCGCGTTT TTAAGGAAGT GATACACAAC 420

CAAAACACGC CTTTTAAGGC TTTTATAGAA AATGAGTTTG GGAGCGTTTT AAGCTTTTCG 480

CCGGAATTGT TTTTTGAATT AGAGTTTTTA GACACAGCGA TTAAGATTAT CACAAAACCC 540

ATGAAAGGCA CGATCGCTCG CTCAAACAAC CCCTTGATAG ATGAAAAAAA CCGATTGTTT 600

TTGCAAAATG ATGACAAAAA TAGAAGCGAA AATGTGATGA TCGTGGATTT ATTGCGTAAC 660

GATTTGAGCC GCTTGGCCTT AAAAAATAGC GTGAAAGTCA ATCAATTGTT TGAAATCATC 720

AGTTTGCCGA GCGTGTATCA AATGATAAGC GAGATTGAAG CTCAATTGCC CCTAAAAACA 780

AGCTTGTTTG AGATTTTTAA GGCGTTGTTC CCTTGCGGCT CTGTGACCGG ATGCCCTAAA 840

ATCAAAACCA TGCAAATCAT TGAAAGTTTA GAAAAACGCC CTAGGGGGGT GTATTGTGGG 900

GCGATAGGCA TGGTTGGAGG AAAAAAAGCC CTTTTTAGCG TGCCTATCCG CACTTTAGAA 960

AAAAGAGCGC ATGAAGATTT TTTGCATTTA GGGGTAGGGA GTGGGGTAAC TTATAAAAGT 1020

AAAGCTTCAA AGGAATATGA AGAGAGCTTT TTAAAATCCT TTTTTGTGAT GCCCAAAATA 1080

GAATTTGAGA TCGTGGAAAC GATGAGAGTT ATCAAAAGGG ATCAAAAATT AGAGATTAAC 1140

AATAAAAACG CCCATAAAGA ACGCTTAATG CATAGCGCCC AATATTTTAA CTTTAAATAC 1200 GATGAAAATC TTTTAGACTT TGAATTAGAA AAAGAAGGGG TTTTAAGGGT TTTACTCAAT 1260

AAAAGGGGCA AGCTCATTAA AGAATACAGA ACCTTAGAGC CTTTAAAAAG CCTAGAAATC 1320

CGTTTGAGTG AAGCCCCCAT TGACAAACAC GATGATTTTT TATACCATAA GACCGCTTAT 1380

GCCCCTTTTT ATCAAAACGC TCGAGCGCTC ATTAAAAAAG GCGTTATTTT TGATGAAATC 1440

TTTTATAACC AGGATTTGGA ACTCACTGAG GGCGCTAGGA GTAATCTTAT TTTAGAAATC 1500

CACAACAGGC TTTTAACCCC TTATTTCAGC GTGGGCGCAT TAACCGGGAC GGGCGTTGTG 1560

GGGTTGTTAA AAAAAGGTCT TGTTGAGCAT GCCCCTTTAA AATTACAAGA CTTGCAAAGA 1620

GCGGCTAAAA TCTATTGTAT TAACGCGCTA TACGGCTTAG TGGAGGTGGG AATAATAGGT 1680

TACCCAATGG AGCAAAAAAG TTAA 1704

(2) INFORMATION FOR SEQ ID NO: 1004:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1125 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...1125

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1004:

ATGAAAATCA GTGTTAGTAA AAACGATTTA GAAAACACTT TGCGCTACTT GCAAGCTTTT 60

TTGGATAAAA AGGACGCTTC CTCTATCGCT TCACACATCC ATTTAGAAGT CATTAAAGAA 120

AAGCTCTTTT TAAAAGCCAG CGATTCAGAT ATTGGACTAA AAAGCTATAT TTCTACGCAA 180

TCTACCGATA AAGAGGGCGT AGGCACGATC AACGGGAAGA AGTTTTTAGA TATTATCTCA 240

TGTTTGAAAG ACTCTAATAT TGTTTTAGAG ACTAAAGATG ACAGCTTGGT GATCAAACAA 300

AATAAAAGCT CTTTCAAACT CCCCATGTTT GACGCTGATG AGTTCCCTGA ATTCCCTGTT 360

ATTGATCCAA AAGTGAGTTT AGAAATCAAT GCCCCCTTTT TGGTGGATGC GTTTAAAAAG 420

ATCGCTCCTG TGATTGAGCA AACTAGCCAT AAAAGGGAAT TAGCCGGTGT TTTAATGCAA 480

TTCAATCAAA AACACCAAAC CCTTTCAGTG GTAGGCACGG ATACCAAGCG GCTCTCTTAC 540

ACGCAGTTAG AAAAAATCTC TATCCATTCC ACCGAAGAAG ACATCTCTTG CATTTTGCCT 600

AAAAGGGCTT TATTGGAAAT CCTTAAACTT TTTTATGAAA ATTTCAGTTT TAAAAGCGAC 660

GGCATGTTAG CGGTGGTTGA AAACGAAACG CACGCTTTTT TCACCAAGCT CATTGATGGG 720

AATTACCCTG ATTATCAAAA AATCCTCCCT AAAGAATACA CTTCTTCTTT CACTTTAGGC 780

AAGGAAGAAT TTAAAGAGGG CATTAAGTTG TGCAGTTCTT TAAGCTCCAC CATTAAGCTC 840

ACTTTAGAAA AAAACAACGC TTTGTTTGAA TCTTTGGATT CTGAGCATAG CGAAACCGCC 900

AAAACCTCTG TTGAGATTGA AAAAGGTTTG GATATTGAAA AAGCCTTTCA TTTGGGCGTG 960

AACGCAAAAT TTTTCCTTGA AGCCTTAAAC GCTTTAGGGA CAACGCAATT TGTTTTAAAA 1020

TGCAATGAGC CTTCTTCGCC TTTTTTGATT CAAGAACCTC TTGATGAAAA GCAAAGCCAC 1080

TTGAACGCTA AAATTTCCAC TTTGATGATG CCAATCACAC TATAA 1125

(2) INFORMATION FOR SEQ ID NO: 1005:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1107 base pairs (B) TYPE, nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY, circular

(11) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE-

(A) NAME/KEY: miscjeature

(B) LOCATION 1...1107

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1005:

ATGGTTGTTT TAGGAAGCAC CGGCTCTATC GGGAAAAACG CCCTTAAAAT CGCAAAAAAA 60

TTTGGTGTAA AAATAGAAGC CTTAAGCTGT GGGAAAAATA TCGCTTTAAT CAATGAACAA 120

ATCAAAGTTT TCAAACCCAA AAAAGTAGCG ATCTTAGATC CTAACGATTT GAATAATTTA 180

GAGCCTTTGG GCGCGGAAGT GTTTGTGGGG TTAGACGGCA TTGATGCGAT GATAGAGGAG 240

TGCGTTTCCA ATTTAGTCAT TAACGCCATT GTGGGCGTAG CCGGATTGAA AGCGAGCTTT 300

AAAAGCTTAC AAAGGAACAA AAAACTAGCC CTAGCGAATA AAGAAAGTTT AGTGAGCGCG 360

GGGCATTTAT TAGACATTTC ACAAATCACG CCCGTTGATA GCGAGCATTT TGGTTTGTGG 420

GCGTTGTTGC AAAACAAGAC TTTAAAGCCT AAATCTTTAA TCATTAGCGC GAGTGGGGGG 480

GCTTTTAGGG ACACGCCCTT AGATCTTATC GCTATTCAAA ATGCGCAAAA CGCGCTCAAG 540

CACCCTAATT GGAGCATGGG GGATAAAATC ACCATTGATT CAGCGAGCAT GGTCAATAAA 600

CTTTTTGAAA TTTTAGAAAC CTATTGGCTT TTTGGTGCGT CTTTAAAGAT TGACGCGCTG 660

ATTGAAAGAA GTTCTATCGT GCATGCTTTG GTGGAGTTTG AAGACAACTC TGTCATTGCG 720

CATTTAGCGA GTGCGGACAT GCAATTACCC ATAAGCTATG CCATTAACCC TAAATTAGCT 780

TCTTTGAGTG CTTCCATTAA ACCCTTAGAT TTATACGCTT TAAGCGCGAT TAAATTCGAA 840

CCCATTAGCG TGGAGCGCTA CACTTTGTGG CGTTATAAAG ATTTGTTGTT GGAAAACCCA 900

AAGCTTGGCG TGGTGCTGAA TGCGAGCAAT GAAGTGGCGA TGAAGAAGTT CTTGAATCAA 960

GAAATCGCTT TTGGTGGCTT TATCCAAATC ATCTCTCAAG CTTTAGAATT GTATGCTAAA 1020

AAATCTTTCA AGCTCTCTAG TTTAGATGAA GTGCTAGCGT TAGATAAGGA AGTTAGGGAG 1080

CGTTTTGGAA GTGTAGCGAG AGTGTAG 1107

(2) INFORMATION FOR SEQ ID NO: 1006:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1254 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE: (A) NAME/KEY: miscjeature

(B) LOCATION 1...1254

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1006:

ATGAAATATT TATGGCTTTT TTTAATATAC GCTATAGGGC TTTTTGCAAC AGATAAAACG 60

CTAGATATTA TTAAAACCAT TCAAAAACTT CCTAAGATTG AAGTGCGCTA CTCCATAGAT 120

AACGATGCCA ATTACGCTTT AAAATTGCAT GAAGTCTTAG CGAACGATTT AAAGACTAGC 180

CAGCATTTTG ATGTTTCTCA AAACAAAGAG CAAGGTGCTA TCAATTACGC AGAACTCAAG 240

GATAAAAAAG TCCATCTTGT AGCGCTTGTG AGCGTGGCGG TAGAAAACGG CAATAAAATT 300

TCACGATTAA AACTTTATGA TGTGGATACA GGAACGCTCA AAAAGACTTT TGACTACCCC 360

ATTGTAAGTT TAGATCTATA CCCTTTTGCA GCGCACAACA TGGCCATTGT GGTGAATGAT 420

TATTTAAAAG CCCCTTCTAT CGCTTGGATG AAGCGCCTGA TTGTTTTTTC TAAATACATT 480

GGACCAGGAA TCACAAACAT CGCACTAGCG GATTATACGA TGCGTTATCA AAAAGAAATC 540

ATCAAAAACA ACCGACTCAA TATTTTCCCC AAATGGGCGA ACGCTGAGCA AACGGAGTTT 600

TATTACACGC AGTATGGCGA AAAAACGCCC ATGATTTTAA AATACAACAT TCAAAAAGCC 660

ACTCATGAGA ATATCGCTAG CTCTCAAGGA ATGGCTGTGG TCTCTAGCGT GAGTTCTGAT 720

GGCTCTAAAA TTTTAATGTC TTTAGCCCCT GATGGCCAAC CGGATGTTTA TTTGTATGAC 780

ACGCATAAAA AAACTAAAAC CAAAATAACG CGCTATCCGG GGATAGATGT TTCAGGCGTG 840

TTTTTAGAAG ATGACAAGTC TATGGCTTTT GTTTCAGATA GATCCGGTTA TCCTAACATC 900

TATATGAAGA AATTGGGGTT AAAAGAGAGC GCGGAGCAAC TCCTTTATGA AGGAAGAAGC 960

AATGAATCCA TTGACGCCTA TAAGGATAGT ATCGTGTATG TGAGCCGAGA AAACCTTAAT 1020

GAATTTGGCA AAACGGTGTT TAATTTGAAT TTGATCGCTC TAAACAGCAA GTATATCCGC 1080

AGGCTTACCG TGAATGGCTC TAACCAGATG CCTAGGTTTT CTATGGATGG GAGAAATATC 1140

ATGTATATCA AAAAGACATC TCAAGAATAC GCCATGGGGC TTATTTTGCT AGACTATAAT 1200

CAGAGTTTTT TATTCCCTTT AAAGAATGTG AAAATACAAG CCTTTGATTG GTAA 1254

(2) INFORMATION FOR SEQ ID NO: 1007:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 660 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...660

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1007:

GTGAATAAAA AGCACCGCTT GGCTTTTTTA GGGCTAATTG TTGGGGTTCT ATTCTTCTTT 60

AGCGCGTGCC AACACCGCCT GCACATGGGG TATTATTCAG AAGTTACAGG GGATTATTTG 120

TTCAATTATA ATTCCACTAT CGTGGTGGCT TATGACAGAA GCGATGCGAT GACTTCTTAT 180

TATATCAATG TGATTGTTTA TGAATTGCAA AAATTAGGCT TTTATAATGT CTTCACGCAA 240

GCGGAATTCC CGCTAGATAA AGCAAAAAAT GTGATCTATG TGCGTATTGT CCGTAATATC 300

TCGGCTGTGC CGTTTTATCA ATACAATTAC CAACTGATCG ATCAAGTCAA TAAGCCTTGT 360

TATTTTCTTG GGGGGCAGTT TTATTGCTCC CAAACCCCTA CGGATTACTA CGCTATCAAT 420 GGCTTTAGCG AGCAAATTTT GATGAGCGCT AATTCGCATT TTATTTTGGA TTGGTATGAT 480

GTGGTGCTGC AAAAACGGGT TTTATATGTG GATGGGAGCG TGAGCGGGAG GACTTGTGGC 540

TATCAGATGC TTTATAGAGA TTTGATTAAA AGCACGATCA AACGCATTGA TTTTAACCGC 600

CCTGAACGCT ACTACTACAA TTTAAGACTG CCCCTTTATC AGCCATGTTA TAGGCAATGA 660

(2) INFORMATION FOR SEQ ID NO: 1008:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1251 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...1251

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1008:

ATGCAATATA AGAAAAATAA GAAAAGATAT TATCATTTAG CGTTAGGGAT CCTTTTTTGT 60

AATGGTCTGT CTTTGAAAGC TTTAGAAATT GCCGTCAAAC CCTTTGGCTA TCTGGGGCTA 120

TTGTATAATC AAGGGACGCA AAAAAACCCT CACAGCTATG TGGGGGCTTT AGCGCGTCTT 180

GGGGTGGATT TTTCTTATAG CAATGGGTGG TCGTTTGGTA TTGGGGCTAT TGGGGCTTGG 240

AATATTTATA ACAAACAGCG TTTGGCTAAC CTTTACATCA GTCTAGGGAA TTTTTTTGGT 300

AACCCTAACA ACGTTAAGCC TTATTTGAGC GCCGGCGATG TTTCTGATGC GTATCTTCAA 360

TACGCTAACC AGCGTTTTAA AATCGCTTTA GGGCGTTTTA ATACCGATTT TGTGGATTTT 420

GATTGGATAG GGGGCAATAT TCAAGGGGTC TCTGTGGCTT TCAAGCAAAA TTCCATGCGT 480

TATTTTGGGA TTTTTATGGA TAGCATGCTT TATAATGGGC ATCAAATCAA TAAAGAGCAA 540

GGGAATCGGA TCGCCACTTC CCTAAACGCT CTAGCGTCTT ATGATCCTGT GTCTAAACGC 600

TTGTATGTAG GGGGGGAAGT GTTTGTTTTG GGCGCAGAAT ACAAAAATAA AAATTTGATA 660

TTCGTTCCTT TTATTTTAAC GGACACCCGC TTGCCTTTGC CCACCCAAAA TGTTTTAGTG 720

CAAGTGGGGG GTAAGTTGGA GTATGACGCT TCTTTAGCTA AGGGTTTCAC TTCGCGCACT 780

CTAGTGCATG GCATGTATCA ATACGGCAAC ACCGATATTA CTACAAGCGC TAAAAATGCC 840

GGCTTGTTTT TGATCGATCA AACTTTCAAA TATAAAATTT TTAATTTTGG AACGGGTTTT 900

TATATCGTTC CGGCAAGGAA CAATAAGGGC TATCTATGGA CTTTTAATGA CAGGACTAAA 960

TTCTATGGCC GTGGGATCAA CGCGCCCGGC GTACCAGCGA TTTATTTTGC TAACTCCAGC 1020

ATTTCAGGCT ATGTTTTTTT AGGGCTTAAG ACTAAAAGGG TGCGTTTAGA TGCGATGGTG 1080

GCTTTTGGGG ATTATCAAGA ATATTCTTTG ATGAGCAGTT TTAGGGTTTG GACTTATAGG 1140

GATTTGTCTT TTGATATGGG TGGGGGGTAT GTGTATGCTT ATAATTCTAA AGCCACGAGA 1200

AAAAGCCTTG GAGATAGCTC TTTTGTCTTT TTTGGGAAGT TTTTGTTTTA A 1251

(2) INFORMATION FOR SEQ ID NO: 1009:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2007 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular (11) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...2007

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 1009:

ATGGTGAAAA ACACCAAAGG CATTCAACAG CTTTCAGAGA ATTATGAAAA GTTGAACAAT 60

CTTTTAAATA ATTACAACAC CCTAAACACT CTTGTAAAGC TGTCCTCCGA TCCGAGTGCT 120

GTCAACGACG CAAGGGATAA TCTAGGCTCA AGCACTAGGA ATTTGCTAGA TGTCAAAGCC 180

AATTCCCCCG CCTATCAAGC GGTGCTTTTA GCATTGAACG CTGCAGTGGG CTTGTGGCAA 240

GTTACAAGCT ATGCCTTTAC CGCTTGTGGT CCTGGTAGCA ATGAGAACGC GAATGGAGGT 300

ATCCAAACCT TTAATAATGT GCCAGGACAA AACACGACGA CCATCACTTG TAATTCGTAT 360

TATGAGCCAG GACATGGCGG GCCAATATCC ACTAAAAATT ATGCGATCAT CAACAAGGCT 420

TATCAAATCA TTCAAAAGGC TTTGACAGCC AATGGAGAAG GGATCCCAGT TTTAAGCAAC 480

ACCACTACAA AACTTGATTT CACTATCAAT GGAGACAAAA GAACGGGTGG CGAACCAAAT 540

AAAAAATTAG TATACCCATG GAGTCATGGG AAAGCTATTT CAACCTCGTG GAATGCAACC 600

ATAACAGCAC CAACAACAGA AAATATCAAT ACAACCAATA GCGCTCAAGA GCTTTTAAAA 660

CAAGCGAGCA TCATTATCAC TACCCTGAAT AGTGCATGCC CAAACTTCCA AAATGGTGGT 720

AGCGGTTATT GGGCAGGGAT AAGTGGCAAT GGGACAATGT GTGGGATGTT TAAGAATGAA 780

ATCAGCGCTA TCCAAGGCAT GATCGCTAAC GCGCAAGAAG CTGTCGCGCA AGCCAAAATC 840

GTTAGTGAAA ACACGCAAAA TCAAAACAGC CTAGACGCTG GAAAACCATT CAACCCCTAC 900

ACAGACGCTA GTTTTGCTGA AAGCATGCTC AAAAACGCGC AAGCCCAAGC GGAGATTTTA 960

AACCAAGCCG AACAAGTGGT GAAAAACTTT GAAAAAATCC CTACAGCCTT TGTAAATGAC 1020

TCTTTAGGGG TGTGTTATGA AGTGCAAGGA GGTGAGCGTC GTGGCACCAA TCCGGGTCAG 1080

ACGACTTCTA ACACTTGGGG GGCAGGCTGT GCGTATGTAG GACAAACGAT AACAAATCTT 1140

AAAAACAGCA TCGCCCATTT TGGCACTCAA GAGCAGCAGA TACAGCAAGC CGAAAACATC 1200

GCTGACACTC TGGTGAATTT CAAATCTAGA TACAGCGAAT TGGGCAACAC TTATAACAGC 1260

ATCACCACTG CGCTCTCTAA TATCCCTAAC GCGCAAAGCT TGCAAAATGC GGTGAGTAAA 1320

AAGAATAACC CCTATAGCCC GCAAGGCATA GACACCAATT ACTACCTCAA TCAAAACTCT 1380

TACAACCAAA TCCAAACCAT CAACCAAGAA CTCGGGCGTA ACCCCTTTAG GAAAGTGGGG 1440

ATTGTTAGTT CTCAAACCAA TAATGGCGCG ATGAATGGGA TCGGTATTCA GGTGGGTTAC 1500

AAACAATTCT TTGGCCAAAA AAGAAAATGG GGCGCTAGGT ATTACGGCTT TTTTGATTAC 1560

AACCATGCGT TCATTAAATC CAGCTTCTTC AACTCGGCTT CTGACGTGTG GACTTATGGC 1620

TTTGGAGCGG ACGCTCTTTA TAATTTCATC AACGATAAAG CCACCAATTT CTTAGGCAAA 1680

AACAACAAGC TTTCTGTGGG GCTTTTTGGG GGTATTGCAT TAGCCGGGAC TTCATGGCTT 1740

AATTCTGAGT ATGTGAATTT AGCCACCATG AATAACGTCT ATAACGCTAA AATGAACGTG 1800

GCGAATTTCC AATTCTTATT CAACATGGGA GTGAGGATGA ATTTAGCCAG GCCTAAGAAA 1860

AAAGACAGCG ATCATGCGGC TCAGCATGGG ATTGAGTTAG GGCTTAAAAT CCCCACCATC 1920

AACACGAACT ACTACTCCTT TATGGGGGCT GAACTCAAAT ACCGAAGGCT CTATAGCGTG 1980

TATTTGAATT ACGTGTTCGC TTACTAA 2007

(2) INFORMATION FOR SEQ ID NO: 1010:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1029 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double (D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...1029

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1010:

TTGACTAAAA AATTCATGTC TTGGATGGTG GTTATCGGGG CTTTAATTTG CGTGCTTTTA 60

GGGGTGTTTA TCTTCTTCAC TAGCATGTCG GTTAAAAAAT CTTTAACCGC TTATCTTAAC 120

GCTTATTTAG AGCAACGCCC AAATATCGAG GGCATGGGGA TTATAGGAGT TCCTTTTAAA 180

TGCGAAGGGT TTTTTAAAAT CGCATGCGTT TCTAAAGAAC TTCGTTTTTT AGATCCTCAA 240

AACTCCCCTA TTATGGATTT TAAAAATTTA AAGATCAAGC TCCATTCTTT AGATAAAAGC 300

TCTCTTACCC TTTCTATCCA TTCTCAAATC CAATCCCCTA TTTTAGAACA ATCCATTCAG 360

CAAAAAATCA GCCAAATCCC CTTAAAAAAC TTGAATGCCT TATTGGAAAA ATTCAAACCC 420

ACGCGCTTGA ATTGCTCTTT AACATTCAAC GCTTTAGATG AAAAAACCTT AAACGATAAT 480

TTAAAATGCG ATTTGACTAA TGCAGAGAAT ATCCTTGCTT ACACTTTTTT TCAAGAAGGT 540

TTAATGGAGG CGCAAGAAAA TCTCTCCCTT AAAAATATTT TTAAAACCTT GAGTTCTAAA 600

GACGCTAAAG CCATAGAAGA GTTGCAAGAC AAACTGCGTT TTTTAGCGCC AAAGTTGAGT 660

GTTTCTATCC AAGCACGCCA TTTTAAAAAC GTTTTAGAGT CCTTTTACCA ACAAAATAAA 720

GAGAGTTTGG GCTTTTTTTC CCCTTATTTT AGTTTGCGTT CTCAAACCCC TAGCGTCTCT 780

TATGAAAGCG CGTTAGCTTC TTTAGAAAAC TATTTTATGG CCTTGTTCCA ATCCCATTTT 840

AAAGACGATA CCGCGCTCCA ACAGAATTTT AAAGGATTGT TGCAAGCCTT TGTTTCTATG 900

GCTAAAGACA AACGATCTCA AATCGTTCTT AACGCCCAAG CTAAAGACAA CACCAAGCTG 960

ACTTTTAACG CCTTGTTAGA AAGCCTAAGC GTGAATTTCT TTCAATCTTA CAAAATAAGC 1020

CATGAGTGA 1029

(2) INFORMATION FOR SEQ ID NO: 1011:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 882 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...882 (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1011:

ATGAGATTGT TGTTCTTGTT ACTGAGCGCT ACTTTGATGT TACTGGCTGA AGAAAAAATA 60

CCTTTAAGCG ATGACGCCCC CATTAAATTG GTTCATTGGC AAAATGCGCT AAAAGAAGTC 120

CAACCCGATT CAAACGCTCC GGCAACGCCA CCTATAAAGG CCGTGCAAAC CACGCTCACT 180

TTTGAAACGC CTTTTAATAA AACGCCTAAA ATCATGGAGG TTGAAGGGCA AAAAGTCATC 240

GTGTTAAAAA ACGCTCAATT GGATTCTAAA AAAACGATGG ATTTTAAAGA AGCCTCTTTG 300

AATGCCTTAG AAATGTTTTC CTACCAAAAT GACATCTACC TCTTGTCTAA AAAAGCTAAA 360

GCGGGATTAG AAATCCAAGC TTCAAGCAGC AAGGATAAAA AGCAACTCCG CTTTCTTTTT 420

TTACCCAAAG GTTTTCATTT AGCCCCACCG CCTAGCCTGA AAGAAAAATC TCAGCATGCC 480

AATCTCGCAA GCCAAGATGA AAAAGAGCGA GCCAAAAGCC CCTCAAACGC TCTAGAGTTA 540

AAACCCCCAC TGGATTTAAG CCATGCTTAC AAGGGGTTAG CGGTTATTGC TGTCTTACTC 600

TTAATATTGT ATGTAATCAA AAAAAAAATT GTTCCTACAC CAGGGTCTTT TTTAAAAAAA 660

GATTTGAAGC TAGACATTAG CGTTTTGGGT CGTGTTGATG CGAACCATAA AATCATCTCA 720

ATAGAAACCA ATAAGGAGCG TTACTTGGTC TTACTAAGCG ACAAATACGG CCTGCTTTTA 780

GACAAAATAA GCCCAAAAAC ATCTAAAGAA GAACTGATTA AAGAAGCTGA AAATAAGATA 840

AAGAATTCAA AATTAGGAAA TTTATATGCC GGAAAATTCT AA 882

(2) INFORMATION FOR SEQ ID NO: 1012:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 861 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 861

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1012:

ATGCTTAGAA ATCAATTTCG TATCGTGTTT GTCTCTTGTA TTGTCGCTAG CAGTTTGCAA 60

GCTCAAGAAA ATACCCACAC TTTGGGTAAG GTAACCACTA AGGGTGAAAG GACTTTTGAA 120

TACAACAATA AAATGTATAT TGACAGGAAA GAGCTCCAAC AACGCCAAAG CAACCAAATC 180

CGTGATATTT TTAGGACTAG GGCGGATGTG AATGTGGCCA GTGGGGGCTT AATGGCGCAA 240

AAAATCTATG TTAGGGGGAT TGAGAGCCGT CTCTTAAGGG TAACGATAGA TGGCGTCGCT 300

CAAAATGGTA ACATTTTCCA CCATGACGCT AACACCGTGA TCGATCCCAA CATGATTAAA 360

GAAGTGGAAG TGATTAAGGG GGCAGCGAAC GCTTCAGCAG GTCCAGGCGC GGTTGCGGGT 420

AAATTGTCTT TCACCACGAT TGACGCTAAC GACTTTTTAA GAAAGAATCA AACTTATGGC 480

GCTAAAGCGG AAGCAGCCTT TTACACTAAC TTTGGATACC GCATGAACGC CACTGCAGCC 540

TATCGGGGGA AAAACTGGGA CATCCTAGCC TATTACAACC ATCAAAATAT TTTTTACTAC 600

AGAGACGGGA ATAACGCTTT TAGGAGTCTC TTCCACCCTA ACTACGATTT ACAAGATCCA 660

AGCAATAGCG AAATGAGCGT AGGGACTCCT AGTGAAGTCA ATAGCGTTTT AGCTAAAATT 720

AATGGCTATA TCAACGAAAC CGATAGCATT AGCGTGAGCT ACAACCTCAC ACGAGACAAT 780

TCTACAAGGC TTTTACGCCC TAACACCACT TCAGCCCTCT CCAAAGCCAA TGACCAGGAA 840

GCCAGCCAGC CCCCTTTGTG A 861 (2) INFORMATION FOR SEQ ID NO.1013

(l) SEQUENCE CHARACTERISTICS-

(A) LENGTH- 1026 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...1026

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1013:

ATGAAACGGC TTTTATTGTT AGCCTTGGCC CTCTTTTTTA GCCTCTCATG CACTAACGCT 60

CAAGAAATTA AAGAAACTCA AGAGACTAAA AAAACTAAAG AAACTAAAAG CCAAACCCGT 120

TTTAACATTT CCACCACTAA GGTCATAGAA AAAGAATTTT CTCAAAGCCG GCGCTATTAC 180

GCGCTTTTAG AGCCTAATGA AGCGCTGATT TTTTCTCAAA CCCTGCGTTT TGATGGCTAT 240

GTGGAAAAGC TTTATGCGAA TAAAACCTAT ACCCCCATTA AAAAGGGCGA TAGGCTATTG 300

AGCGTGTATT CCCCTGAATT AGCGGGCGTT CAAAGCGAGC TGTTATCGTC ATTGAAATTC 360

AACCAGCAAG TGGGAGCGAT TAAAGAAAAA TTAAAACTAC TAGGGCTAGA AAACTTTAGC 420

ATTGAAAAAA TCATCAGCAG CCATAAAGTC CAAAATGAAA TCACTATTTA CTCTCGTTTC 480

AACGGCGTTA TTTTTAAAAA AAGCCCGGAT CTCAATGAGG GGAGTTTCAT TAAAAAAGGG 540

CAAGAGCTTT TCAAAATCAT AGATTTAAGC CGATTGTGGG CGCTTGTTAA AGTCAATCAA 600

GAGGATTTAG AATTTTTAAA AAACACGCAT CAAGCGATTT TGTTCGTAGA GGGGGTTAAA 660

GGCAAGCAAG CAATCACGCT TGAAAACATC AACCCCATCA TAAATGCGCA AGATAAAATG 720

CTAGAAGCGC GCTTCAATGT GCCTAATCTT AAATTGCTTT ATTACCCTAA CATGTTCGCT 780

CAAGTAGAAA TCTTTCACAA ACCCCAAAAA ATGAAGATCT TGCCTAAAGA AGCGGTTTTG 840

ATTAAGGGGG GGAAAGCTAT CGTGTTTAAA AAAGATGATT TTGGCTTAAG CCCGTTAGAA 900

ATTAAAGCCG TCCGCTTGAG CGATGGGAGT TATGAAATTT TAGAGGGTTT AAAAGCGGGC 960

GAAGAAGTCG CTAATAACGC TTTATTCGTG CTAGACGCTG ACGCTCAAAA CAATGGGGAT 1020

TATTGA 1026

(2) INFORMATION FOR SEQ ID NO: 1014:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1392 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE: (A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...1392

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1014-

ATGGCTTTTT GCGCTCGCCA AAAGCCTCTA AAGGAAATCA TGCGTTTTTT TATTTTATTT 60

TTTATGGGTA TGCTTGGCGT TGGTTTTTCT CAAACCGAGT TGGATTTAAA GGATTTAGAA 120

AAAAAGCCCG CCGGGATCGT TAGGGATTAT TATTTATGGC GTTATATTAG CGATAAAAAA 180

ACGAGTTTAG AAAACGCTAA AAAAGCCTAT GAATTGACTC AAAATAAAAA CAGCGCCCTA 240

CAAAAAGCCA TGCAAGAAAA AGGCGTAGAA AATTCAGATA AAAGCCCTGA TGCCAAAATG 300

CCTGAAGATA TTTATTGCAA GCAAATTACC TTAGAAAGCA TGTTAGAAAC AACAGACGCT 360

TTCCAAGCGA GTTGTATCGC TATCGCTTTA AAATCAAAAA TCAGAGATTT TGATAAAATC 420

CCCATTCAAA CCTTTAAACC TTTACAAGAA AAAATCAAAG AGGCTTACCC CATTCTTTAT 480

GAAGAATTAG AAATCTTGCA AAGTAAGAAC GTGAGCGCTT CTTTGTTTAA GGCTAACGCG 540

CAAGTGTTTA GCGCGCTCTT TAATCATTTG AGTTATGAAA AAAAGCTCCA AATTTTTGAA 600

AAGCATATCC CGATTAAAGA GTTAAACCGC CTTTTAGATG AAGATTACCC GGCGTTTAAC 660

CGCTTGATCT ATCAAGTCAT CTTAGATCCT AAATTGGATC ATTTTAAAGA CGCTCTCGCT 720

AAAAGTAACG CCACCCAAAG CAACGCGCAA ACCTTTTTTA TTCTAGGAAT CAATGAAATC 780

TTGCACAAAA AAACTTCTAA AGCGCTCAAG TATTTTGAAC GCTCAGAAGC GGTTGTCAAG 840

GACGATGATT TTTCAAAAGA CAGAGCGATT TTTTGGCAGT ATTTAGCCTC TAAAAAGAAA 900

AAAACTTTGG AGCACCTTTC ACAAAGCCCA GCCCTAAACC TCTATAGTCT TTATGCGAGC 960

CGCAAACTCA AAACCACGCC CAGTTATCGC ATCATTTCTC ATATCCAAAA TTTAAGCCAA 1020

GAGAACCCTC CTTTTAACAC TTACGATCCT TTTTCGTGGC AAATTTTTAA GGAAAAAACT 1080

TTGAGTTTGA AAGATGAGGG CGCGTTTAAT GCGATGCTAA AAAGCCTGTA TTATGAAAAA 1140

AGCGCTCCTG AATTGACTTA CCTTTTAAGC CAACGCAATA AAGACAAGAT TTATTATTAT 1200

TTATCCCCTT ATGAGGGCAT TATTGAGTGG CAAAATACAG ATGAAAGGGC TATGGCGTAT 1260

GCGATCGCTA GGCAAGAAAG CTTTTTGCTC CCGGCTTTAA TCTCTCGCTC CTTCGCTCTA 1320

GGGCTTATGC AGATCATGCC TTTTAATGTA GGGCCTTTCG CTAAAGCCTT GGCATGGATA 1380

ATGTTGATCT AA 1392

(2) INFORMATION FOR SEQ ID NO: 1015:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1125 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...1125

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1015: ATGCCAAAAA GAATGAAGTG TTTTAGTCAA AAATGGTTGG TTTTTTTTGT TACCCATTGG 60 CTTTTGTTGG CTTCTTTAAG TCATGCGAAG ATGGCTTTTG AATCCAATAT TGACACCAAA 120

GCGTTAGAGG CTTTTGGGGT CAATGCGAGC TTTTTATCCC AAATGCCAGG CGCTTTAAAA 180

AAGGTGAATA AGGAAGAGGA ATGGAAAAAG TTAGTCAAAA GATTTGACGT GAATTACCAA 240

TTCATCCCTA TCATTAAAAA CATGCTCATA GGAGCGAGCG TGCCGCAAGA ATTTTTGTTT 300

TTAGCCATGG CCGAGTCTAA GTTTTCATCA AGGGCTTATA GCAGGAAAAA AGCGGTAGGG 360

ATTTGGCAAT TCATGCCAAG CACGGCCAAA GAGTTAGGGC TTAAGGTCAA TCATTACATT 420

GATGAAAGAA GAGATCCCAT TAAAAGCACT CAAGCGGCGA TCGCTTATTT GAAACGGCTC 480

TACAAGCAAA CCGGTGAGTG GTATTTGGTC GCTATGGCGT ATAATTACGG CTTACGCAAG 540

GTTCAAAACG CTATTAAAGC CGCCGGCACT TCAGACATTA AAGTCTTGCT AGATGAAGAT 600

AAAAAATACC TCCCTAAAGA AACACGAGAG TATATCCGCT CCATTCTAAG CCTGGCGTTG 660

AAATTCAACA GCCTAGACAA TCTCAAAGAT AAAGAGTATT TGCTCAATCG TGGGGCGAGG 720

GTGAGTTTAG TGGGCGTCCC GTTTAAAAGA CACACTTCTT TAGTCCAGGT GGCCAAAAAT 780

TTGAATTTGA GTTTAGAAAC CTTAAAATCT TACAACCACC AATTCCGCTA TAACATTCTG 840

CCCTCTAAAG ACCCCACCTA CACCATTTAT ATCCCTTATG AAAAACTCGC CCTTTTCAAA 900

CAACGCCAAC TCAAACAAAA TAAAAACGCT CAAGCTAATC CTAAAAGCCC TTTCATCACC 960

CATGTGGTCT TGCCTAAAGA AACCTTATCT TCTATCGCTA AACGCTATCA AGTCAGCATT 1020

TCCAGTATCC AATTAGCCAA TAACCTCAAA GATTCTAATA TCTTTATCCA CCAGCGCTTA 1080

ATCATCCCCA CTAACAAAAA ATTACTCGCT ACAAGGGAAT TTTAA 1125

(2) INFORMATION FOR SEQ ID NO: 1016:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1002 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...1002

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1016:

ATGCTAATCG CTCGCTTTAA AAAAGCTTTA ATTTCCTATT CTTTAGGGGT TCTTCTTGTT 60

TCATCGTTAT TAGGCGTGGC TAACGCTTCT AATCAAGAGA TCCAAGTCAA GGATTATTTT 120

GGGGAGCAAA CCATAAAGCT TCCTGTTTCT AAAATAATCT ACTTGGGCAG CTTTGCAGAA 180

GTGCCTGCCA TGTTCAATAC TTGGGATAGG GTCGTGGGCA TTTCGGATTA CGCTTTTAAA 240

TCTGATATTG TTAAAGCCAC TCTCAAAGAT CCTGAACGCA TTAAACCCAT GAGCAGTGAT 300

CATGTGGCGG CGTTGAATGT GGAATTATTA AAAAAGCTTA GCCCTGATCT TGTGGTAACC 360

TTTGTGGGTA ACCCTAAAGC GGTAGAGCAT GCGAAAAAAT TTGGGATTTC ATTCCTTTCT 420

TTCCAAGAAA AAACCATTGT AGAGGTCATG GAAGATATTG ACGCTCAAGC TAAGGCCTTA 480

GAAGTTGACG CTTCTAAAAA ATTGGCTAAA ATGCAAGAAA CTTTGGATTT TATCAAAGAG 540

CGTTTGAAAA ATGTCAAAAA GAAAAAGGGG GTGGAGCTTT TCCATAAAGC CAATAAAATC 600

AGCGGCCATC AAGCCCTTGA TTCAGATATT TTAGAAAAAG GGGGCATAGA CAATTTTGGC 660

TTGAAATACG TCAAGTTTGG GCGCGCTGAC ATTAGTGTGG AAAAAATCGT TAAAGAAAAC 720

CCTGAGATTA TTTTTATTTG GTGGATAAGC CCGCTTAGCC CTGAAGACGT GTTGAACAAC 780

CCTAAATTTT CCACTATCAA AGCCATTAAA AACAAGCAAG TCTATAAGCT CCCCACAATG 840

GATATTGGCG GACCTAGAGC CCCACTCATT AGTCTTTTTA TCGCTTTAAA AGCCCACCCT 900 GAAGCGTTTA AGGGCGTGGA TATTAATGCG ATAATCAAAG ATTACTATAA AGTGGTCTTT 960 GATTTGAATG ACGCGGAAGT TGAACCCTTT TTGTGGCACT GA 1002

(2) INFORMATION FOR SEQ ID NO: 1017:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1602 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...1602

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1017:

ATGGAAATTA GAAACATCAA AGAGTTTGAA AAAGCTTCCA AAAAACTCCA AAAAGACACT 60

TTAAAGATCG CTCTCGCTCT TTTGTTCCTC ATTGGCGCCG CTTTGCTCGC TCTCATTTTT 120

GGGCAGGCTA ATTCTAAGGG ATTGTTGCTC ATCTTTGCGG CCGTGATTGG GGGGTATATG 180

GCGATGAATA TTGGCGCGAA CGATGTGTCT AATAATGTCG GCCCTGCCGT AGGCTCTAAA 240

GCCATTAGCA TGGGTGGGGC GATTTTGATC GCTGCGGTTT GTGAAATGCT AGGAGCGATC 300

ATTGCTGGGG GGGAAGTGGT TTCTACGATT AAGGGCCGTA TCGTTTCGCC TGAATTTATT 360

AACGATGCGC ATGTTTTCAT TAATGTCATG TTGGCTAGCC TTTTGAGTGG GGCGTTATGG 420

TTGCATGTAG CCACTTTAAT AGGCGCTCCC GTTTCCACTT CGCACTCCGT AGTGGGAGGG 480 ATTATGGGGG CTGGAATGGC AGCAGCTGGA ATGTCTGCTA TCAATTGGCA TTTTTTATCC 540 GGCATTGTGG CTAGTTGGGT AATCTCGCCT TTAATGGGGG CTTTGATAGC CATGTTTTTT 600 TTAATGCTCA TTAAAAAGAC TATCGCTTAT AAAGAAGATA AAAAGAGCGC GGCTTTAAAG 660

GTCGTGCCTT ATTTGGTGGC GTTGATGAGC TTAGCCTTTA GCTGGTATTT GATCGTGAAG 720

GTTTTAAAAC GCCTCTATGC GGTGGGTTTT GAAATCCAGC TCGCTTGCGG TTGTGTCCTT 780 GCGCTTTTGA TTTTTATCCT TTTTAAAAGA TTTGTGTTAA AAAAAGCCCC GCAATTAGAA 840 AATAGCCACG AAAGCGTCAA TGAGCTTTTT AATGTCCCTT TGATTTTTGC CGCCGCGCTT 900 TTAAGCTTTG CGCATGGGGC TAATGATGTA GCTAACGCTA TCGGTCCTTT AGCCGCAATC 960

AGTCAAACTT TAGAAGATGC GAGCAGCCCT ATGGGGAGTA CTTTAAACTC TGTGCCGTTG 1020

TGGATTATGG TAGTAGGGGC AGCTGGGATC GCTTTAGGCT TGAGCTTGTA TGGGCCAAAG 1080

CTCATTAAAA CGGTGGGGTC TGAAATCACA GAATTAGACA AAATGCAAGC TTTTTGCATC 1140

GCGCTTTCAG CGGTCATCAC CGTGCTTTTA GCCTCTCAAT TAGGCTTACC GGTAAGCTCT 1200

ACGCATATTG TGGTGGGCGC GGTGTTTGGG GTGGGCTTTT TAAGGGAGCG TTTGAGGGAG 1260

CAATCCAGAA GGCGTTTTGC TAGAATCAGA GACAACATTG TAGCGGCGCA CTTTGGGGAA 1320

GATTTAGAAG AAATTGAAGG CTTTTTAGAG CGCTTTGATA AAGCCAATTT GAAAGAAAAA 1380

TCGCTCATGC TAGAGAGCTT GAAAAAAAGC AAGAACACCG CTATCGCTTT GGAATTGAAA 1440

AAGAAAGAAA AAAAGTCGCT TAAAAAAGTG TATAAAGAAG AAGTGATCAA ACGCTCCATT 1500

TTGAAAAAGA TTGTTACCGC TTGGTTGGTA ACCGTGCCGG TTTCTGCGCT TTTAGGGGCG 1560

CTTCTTTTTG TAGCTCTTGG TTTTATAGAA AAGTATTTCT AG 1602

(2) INFORMATION FOR SEQ ID NO: 1018:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 990 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...990

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1018:

ATGTCAAATA GCATGTTGGA TAAAAATAAA GCGATTCTTA CAGGGGGTGG GGCTTTATTG 60

TTAGGGCTAA TCGTGCTTTT TTATTTGGCT TATCGCCCTA AGGCTGAAGT GTTGCAAGGG 120

TTTTTAGAGG CTAGGGAATA CAGCGTGAGC TCTAAAGTCC CTGGCCGCAT TGAAAAGGTG 180

TTTGTTAAAA AAGGCGATCG CATTAAAAAG GGCGATTTAG TTTTTAGCAT TTCTAGCCCT 240

GAATTAGAAG CCAAGCTCGC TCAAGCTGAA GCCGGGCATA AAGCCGCTAA AGCCGTTAGC 300

GATGAAGTGA AAAGAGGCTC AAGAGATGAA ACGATCAATT CTGCGAGGGA CGTTTGGCAA 360

GCGGCAAAAT CCCAAGCGAA TTTGGCTAAA GAGACTTATA AGCGCGTTCA AGATTTGTAT 420

GACAATGGCG TGGCGAGTTT GCAAAAGCGC GATGAAGCCT ATGCGGCTTA TGAAAGCACC 480

AAATACAACG AGAGCGCGGC TTACCAAAAG TATAAAATGG CTTTAGGGGG GGCGAGTTCT 540

GAAAGCAAGA TTGCCGCTAA GGCTAAAGAG AGCGCGGCTT TAGGGCAAGT GAATGAAGTG 600

GAATCCTACT TAAAAGACGT CAAAGCCCTA GCCCCTATTG ATGGGGAAGT GAGTAACGTG 660

CTTTTAAGCG GTGGCGAGCT TAGCCCTAAG GGCTTTCCTG TGGTGCTCAT GATAGATTTA 720

AAGGATAGTT GGTTAAAAAT CAGCGTGCCT GAAAAGTATT TGAACGAGTT TAAAGTGGGT 780

AAGGAATTTG AAGGCTATAT CCCAGCGTTG AAAAGAAGCG CGAAATTCAG GGTCAAATAT 840

TTGAGCGTGA TGGGGGATTT TGCGACCTGG AAAGCGACGA ATAATTCCAA CACTTACGAC 900

ATGAAAAGCT ATGAAGTGGA GGCCATACCC TTAGAAGAGT TGGAAAACTT TAGGGTGGGG 960

ATGAGCGTGT TGGTTACCAT TAAACCTTAA 990

(2) INFORMATION FOR SEQ ID NO: 1019:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 879 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature (B) LOCATION 1...879

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1019:

AGACTGGAAT CACCGCTACA CTCAGGCTTT AGCCCTAGCG CGGCCCTTGT GATCAGCCCC 60

ATTGAGCCTT TATCTCTAAA AATCACTTAT TCTCAAGTTA CAAGGGGGGT TATGCCAGGA 120

GATGGCGTGT ACATGCGTCA AAACGATTTA CGATACGCTA AAAATATCAA GCCTGAAGTG 180

GGCTCTAACG CTGAATTTAA TATTGACTAT TCAAGCCAGT ATTTTAGCGG GAGGGCTGCG 240

GCGTTCTATC AAGCTTTGGA TAATTTCATC TCACAATACG CGCAACGCTT GATCGTAACC 300

AATTTGAGTC AAGCGATTCG CATTTATGGC TATGAAGTGG GTGGGACTTT TAGATACAAG 360

GGCGTGAGTT TGAATGTGGG GATCTCGCGC ACTTGGCCCA CCACTAGGGG GTATTTAATG 420

GCGGACAGCT ATGAGCTTGC CGCAAGCACC GGTAATGTTT TTATCATTAA ATTGGATTAC 480

ACCATTCCAA AAACAGGGAT CAATCTTGCA TGGCTTAGCC GCTTTGTTAC CGGTTTGGAT 540

TATTGCGGGT TTGATATTTA CTTGCCTGAT TATGGGACAG CTGAAAAACC CAAAACCCCT 600

ACCGATTTAG CCAAATGCGG ATCCCAATTG GGGTTAGTGC ATATGCACAA ACCGGGCTAT 660

GGCGTGAGTA ATTTTTATAT CAATTGGAGC CCTAAAACCA AAAGCCACTG GAAGGGTTTG 720

CTGCTTTCAG CCGTGTTTAA TAATGTTTTC AACAAATTCT ATGTGGATCA AACAAGCCCC 780

TATGTCATGA GCCCGGATAT GCCAGGCACT GACGCTATTA AAAGAGCGAT CGCAGAGCCT 840

GGGTTTAATG CGCGTTTTGA AGTGGCTTAC AAATGGTAG 879

(2) INFORMATION FOR SEQ ID NO: 1020:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1455 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...1455

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1020:

ATGGCTAAAA TCACAACCGT GATTGACATA GGCTCTAATT CAGTGCGTTT GGCTGTCTTT 60

AAAAAGACGA GCCAGTTTGG GTTTTACTTG CTTTTTGAGA CTAAGTCCAA GGTTAGGATT 120

TCAGAGGGCT GTTATGCGTT TAAAGGGGTT TTACAAGAAA TCCCCATGCA ACGAGCCGTT 180

AAAGCCTTGA GCGAATTTAA AGAAATCGCC CTCAAATACA AAAGCAAAAA AATCCTGTGC 240

GTGGCGACCT CAGCGGTGCG CGATGCCCCT AATCGGTTAG AGTTTGTAGC GAGGGTGAAA 300

AAGGCTTGCG GTTTGCAAAT CAAAATCATT GATGGGCAAA AAGAAGCGCT CTATGGTGGG 360

ATCGCGTGCG CGAATTTGCT GCATAAAAAT TCAGGGATCA CGATAGACAT TGGAGGGGGT 420

AGCACCGAGT GCGCGTTGAT TGAGAAAGGT AAGATTAAGG ACTTAATCTC GCTTGATGTC 480

GGGACGATTC GCATTAAAGA AATGTTTCTA GACAAAGACT TAGATGTCAA ATTGGCTAAA 540

GCCTTTATCC AAAAAGAGGT CTCTAAACTG CCTTTTAAGC ATAAAAACGC CTTTGGGGTG 600

GGGGGGACGA TCAGAGCCTT GAGTAAGGTG CTGATGAAAC GCTTTGATTA CCCTATAGAT 660

TCTTTGCATG GCTATGAAAT AGATGCGCAT AAAAATTTAG CGTTCATTGA AAAAATCGTC 720

ATGCTCAAAG AAGACAAATT ACGGCTTTTA GGGGTGAATG AAGAGCGTTT GGATAGCATT 780

AGGAGCGGGG CGTTGATTTT ATCAGTCGTG TTAGAGCATT TGAAAACTTC CTTGATGATC 840 ACTAGCGGGG TAGGGGTGAG AGAGGGCGTG TTTTTGAGCG ATTTATTGCG CCACCATTAC 900

CATAAATTCC CCCCCAATAT CAACCCCTCT CTCATCTCTC TAAAAGATCG CTTTTTACCC 960

CATGAAAAGC ACAGCCAAAA GGTCAAAAAA GAATGCGTGA AATTGTTTGA AGTTTTATCG 1020

CCTTTGCATA AAATAGATGA AAAATACCTT TTCCATTTAA AGATTGCGGG GGAATTGGCG 1080

AGCATGGGTA AGATTTTAAG TGTATATTTA GCCCACAAGC ACAGCGCGTA TTTCATTTTA 1140

AACGCTTTGA GTTACGGCTT TAGCCACCAG GATAGGGCGA TCATTTGCTT ATTGGCGCAA 1200

TTTAGCCATA AAAAAATCCC TAAAGACAAC GCTATCGCCC ACATGAGTGC GATGATGCCA 1260

AGCCTTTTGA CCTTGCAGTG GCTGAGTTTT ATCCTTTCTT TAGCCGAAAA TTTGTGCCTG 1320

ACAGACAGCC ATCATTTAAA ATACACGCTA GAAAAAAACA AGCTTGTGAT CCATTCTAAT 1380

GATGCGCTTT ACTTGGCTAA AGAAATGCTC CCCAAACTCA TTAAGCCCAT TCCTTTGACG 1440

ATAGAGTTTG CTTGA 1455

(2) INFORMATION FOR SEQ ID NO: 1021:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 669 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 669

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1021:

ATGGTAGGAA TGAAAACTGA GATGAAATCT TTTTTAAAAC TTTTTGCACA GCCTTTGTTG 60

GTGGTTTTAG CGTTCATGTT GTTGTATGCT TTAGCGCATG CTGTGCTTGG TTTTTACGTG 120

AAAAAAGACA GCGCTCCAAT GAGTCCAAAT GTAGAAAAAA GCGAGACAGA GCGCCAAAAC 180

AGCACGTTTT CGCCTAAAGA AGAAGCCAAC GCAACCACAA CCGCCACAGA ACAAAACCCC 240

ACCAAAGACA CAGTGCCACC TTTAGACACA GCCACACAAA AACAAGAGAT TAAACAAGAG 300

ATTAAACAAG AGATTAAACA AGAGATTAAA CAAGAGATTA AACAAGAGAT TAAACAAGAG 360

ATTAAACAAG AAACTAAACA AGAGCAAGAA AAAGAAAATA AGCCTAAACA AAACAGTGTC 420

TCGCCCGTTC AAAACGATCA AAAAACCCCC ACAACCCCCT TAATGGGAAA AAAACCTCTA 480

GAGTATAAAG TCGCAGTCAG TGGCGTGAAC GTGCGCGCTT TTCCTAGCAC AAAAGGCAAA 540

ATCATTGGCT CGCTTATAAA AAATAAAAGC GTGAAGGTTT TAGAAATCCA AAACGATTGG 600

GCTGAAATTG AATTTTCTCA CGAAACAAAG GGATATGTGT TTTTAAAACT TTTAAAAAAG 660

GCTGAATGA 669

(2) INFORMATION FOR SEQ ID NO: 1022:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 408 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL : NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 408

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1022:

GAGCCTGATG CAACAAGCCG CAGAACATTG AATCACCCCT ATTTTGGCGT TTTTGTTTTG 60

TTGGTATTCA CCTTTTGGGT GTTTAACTTA ACCTTAAGGA TTCAAAGGTT TTTAAGCCGT 120

AAAATGGCTC AAAAAAAGGG CGAAAAGCTC AAGCTCGCTC CCTATGAATG TGGGCCTGTG 180

GCTCTCAAGC AGCCTAATAG GGTGTCCCAT CATTTTTATA TCATGGCCAT GCTTTTTATT 240

TTATTTGATG TAGAAATCGT TTTCATGTTC CCTTGGGCGA TTGATTTTAA AAAGTTAGGC 300

TTGTTTGGGC TCGTTGAAAT GCTAGGCTTT GTCTTCTTTT TGGCAATCGG TTTTATTTAC 360

GCTTTAAAGC GAAACGCTTT GAGCTGGCAA AAATTAGAGG TGAAATAA 408

(2) INFORMATION FOR SEQ ID NO: 1023:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1908 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...1908

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1023:

CTGTCCTCCG ATCCGAGTGC TGTCAACGAC GCAAGGGATA ATCTAGGCTC AAGCACTAGG 60

AATTTGCTAG ATGTCAAAGC CAATTCCCCC GCCTATCAAG CGGTGCTTTT AGCATTGAAC 120

GCTGCAGTGG GCTTGTGGCA AGTTACAAGC TATGCCTTTA CCGCTTGTGG TCCTGGTAGC 180

AATGAGAACG CGAATGGAGG TATCCAAACC TTTAATAATG TGCCAGGACA AAACACGACG 240

ACCATCACTT GTAATTCGTA TTATGAGCCA GGACATGGCG GGCCAATATC CACTAAAAAT 300

TATGCGATCA TCAACAAGGC TTATCAAATC ATTCAAAAGG CTTTGACAGC CAATGGAGAA 360

GGGATCCCAG TTTTAAGCAA CACCACTACA AAACTTGATT TCACTATCAA TGGAGACAAA 420

AGAACGGGTG GCGAACCAAA TAAAAAATTA GTATACCCAT GGAGTCATGG GAAAGCTATT 480

TCAACCTCGT GGAATGCAAC CATAACAGCA CCAACAACAG AAAATATCAA TACAACCAAT 540

AGCGCTCAAG AGCTTTTAAA ACAAGCGAGC ATCATTATCA CTACCCTGAA TAGTGCATGC 600

CCAAACTTCC AAAATGGTGG TAGCGGTTAT TGGGCAGGGA TAAGTGGCAA TGGGACAATG 660

TGTGGGATGT TTAAGAATGA AATCAGCGCT ATCCAAGGCA TGATCGCTAA CGCGCAAGAA 720 GCTGTCGCGC AAGCCAAAAT CGTTAGTGAA AACACGCAAA ATCAAAACAG CCTAGACGCT 780

GGAAAACCAT TCAACCCCTA CACAGACGCT AGTTTTGCTG AAAGCATGCT CAAAAACGCG 840

CAAGCCCAAG CGGAGATTTT AAACCAAGCC GAACAAGTGG TGAAAAACTT TGAAAAAATC 900

CCTACAGCCT TTGTAAATGA CTCTTTAGGG GTGTGTTATG AAGTGCAAGG AGGTGAGCGT 960

CGTGGCACCA ATCCGGGTCA GACGACTTCT AACACTTGGG GGGCAGGCTG TGCGTATGTA 1020

GGACAAACGA TAACAAATCT TAAAAACAGC ATCGCCCATT TTGGCACTCA AGAGCAGCAG 1080

ATACAGCAAG CCGAAAACAT CGCTGACACT CTGGTGAATT TCAAATCTAG ATACAGCGAA 1140

TTGGGCAACA CTTATAACAG CATCACCACT GCGCTCTCTA ATATCCCTAA CGCGCAAAGC 1200

TTGCAAAATG CGGTGAGTAA AAAGAATAAC CCCTATAGCC CGCAAGGCAT AGACACCAAT 1260

TACTACCTCA ATCAAAACTC TTACAACCAA ATCCAAACCA TCAACCAAGA ACTCGGGCGT 1320

AACCCCTTTA GGAAAGTGGG GATTGTTAGT TCTCAAACCA ATAATGGCGC GATGAATGGG 1380

ATCGGTATTC AGGTGGGTTA CAAACAATTC TTTGGCCAAA AAAGAAAATG GGGCGCTAGG 1440

TATTACGGCT TTTTTGATTA CAACCATGCG TTCATTAAAT CCAGCTTCTT CAACTCGGCT 1500

TCTGACGTGT GGACTTATGG CTTTGGAGCG GACGCTCTTT ATAATTTCAT CAACGATAAA 1560

GCCACCAATT TCTTAGGCAA AAACAACAAG CTTTCTGTGG GGCTTTTTGG GGGTATTGCA 1620

TTAGCCGGGA CTTCATGGCT TAATTCTGAG TATGTGAATT TAGCCACCAT GAATAACGTC 1680

TATAACGCTA AAATGAACGT GGCGAATTTC CAATTCTTAT TCAACATGGG AGTGAGGATG 1740

AATTTAGCCA GGCCTAAGAA AAAAGACAGC GATCATGCGG CTCAGCATGG GATTGAGTTA 1800

GGGCTTAAAA TCCCCACCAT CAACACGAAC TACTACTCCT TTATGGGGGC TGAACTCAAA 1860

TACCGAAGGC TCTATAGCGT GTATTTGAAT TACGTGTTCG CTTACTAA 1908

(2) INFORMATION FOR SEQ ID NO: 1024:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 525 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 525

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1024:

ATCAAACGCA TCATTAAATC AAACGCATCA TTAAATCAAT TAAATACCAC TAGATACAAT 60

ACCCCAAGTC ATCTTTTTTT CAAAAAAGGG GTAGGAATGG CAACCATTCA ACCATTCAAC 120

CATTCAACCA TTCAACCATT CAACCATTCA ACCATTCAAC CATTCAATCA TTCAATCATT 180

CAATCATTCA ATCATTCAAC CATTCAAGCA ACGCTACCTT ATTTTTATAA CTATTTATCT 240

TTTTACAAAA ACCTATTTAA AAATCCCCTA TTTTTTATTA TTCCCCCTTT TATTAACCCT 300

TTTATTAACC CTTTTATTAA CCCTTTTATT AACCCTTTTA TTAACCCTTT TATTAACCCT 360

TTTATTAACC CTTTTATTAA CCCTTTTATT AACCCTTTTA TTAACCCTTT TATTAACCCT 420

TTTATTAACC CTTTTATTAA CCCTTTTATT AACCCTTTTA TTAACCCTTT TATTTCCCCT 480

TCATTAACCC ACGCTACAAC ATTTTCAAAC CATTTGATTC CATAA 525

(2) INFORMATION FOR SEQ ID NO: 1025:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2247 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS. double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...2247

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1025:

ATGGAAGACT TTTTGTATAA CACCTTATAT TTCATAGAGG ATTATAAGTT GGTTGTTATT 60

TTTAGTTTCA TAGGGTTAAT AGCGTTATTT TTCCTCTACA AATTCATAAA AACTCAAAAA 120

AAGGTTTTTA AAGATAAAGC TAACCAGCCT CAAAAGAAAA AAAGCTTTAA AGAAATCATT 180

ATAGATGGGC TGAAAGAAAG GGTTAAAACC TTTGGCTTTT GGTTGCAAGC TATACTATTA 240

CTATCCTATT CTTTTATCAC ATCAGGGTTA TTTTTCTTGA TTCTCTTAGG TAATTTTTAT 300

GATGATAATA GATTGCCTGA GAGCGATGAT GATCTTTTTG ATATATGGGT CTATGCGATA 360

CAAGATTTTC CTGCATACTA TTTTAAGGCA CTCACTTTTA GCTCGCTCAA GATTTATGGG 420

TTCAATATAT CCTTAGTCGT ATATAGTTCT ATTTTATGCT CTTATATATT CATTACCTTT 480

TTTGTGTGGT TCTTAAAATA CTTAACTCGG ACTAGGGACA TAGGAGCGAA TAAAAAAGTT 540

GATGATCTCT TTGGTAGCGC GAGTTGGGAA ACTGAAGAGA AAATGATCAA AGCCAAGCTT 600

ATCACACCCA ACAATAAAAA ACGCGCCTTT GACAAACGAG AGGTTATTGT AGGCAGGCGT 660

GGCTTAGGGG ATTTTATCGC TTACGCAGGA CAGGCGTTTA TTGGCTTGAT TGCTCCTACT 720

AGGAGCGGTA AGGGTGTGGG TTTCATCATG CCCAATATGA TCAATTACCC TCAAAATATC 780

GTTGTGTTTG ATCCTAAGGC TGACACTATG GAAACTTGCG GGAAAATCAG AGAAAAACGC 840

TTCAACCAAA AAGTGTTCAT CTATGAACCT TTCTCCTTAA AAACACACCG ATTTAATCCT 900

TTCGCTTATG TGGATTTTGG TAATGATGTG GTTTTGACTG AAGACATACT CTCTCAAATT 960

GACACACGCC TAAAAGGGCA TGGCATGGTG GCTAGTGGAG GGGATTTTTC CACTCAAATC 1020

TTTGGATTGG CTAAGTTGGT GTTCCCTGAA AGACCTAATG AAAAAGATCC TTTTTTTAGC 1080

AATCAGGCGC GAAACCTTTT TGTCATCAAT TGCAATATTT A AGGGATCT CATGTGGACT 1140

AAAAAGGGGC TTGAGTTTGT CAAAAGAAAA AAAATCATCA TGCCTGAAAC CCCCACGATG 1200

TTTTTCATAG GTTCTATGGC AAGCGGTATC AACTTGATTG ATGAAGACAC AAACATGGAA 1260

AAAGTCGTGT CTTTAATGGA ATTTTTTGGA GGTGAAGAAG ATAAGAGTGG CGACAATCTA 1320

AGAGCGCTTA GTCCTGCCAC TAGAAACATG TGGAATAACT TCAAGACAAT GGGTGGCGCT 1380

AAAGAAACTT ACAGCTCGGT TCAAGGGGTC TATACATCAG CGTTTGCGCC TTACAATAAC 1440

GCCATGATCA GGAATTTCAC GAGCGCTAAT GATTTTGATT TCAGGCGTTT AAGGATCGAT 1500

GCAGTGAGTA TTGGTGTGAT CGCTAATCCT AAAGAAAGCA CTATTGTTGG ACCGATATTA 1560

GAGCTGTTTT TCAACGTGAT GATTTATAGC AATTTGATTC TGCCAATCCA TGATCCACAA 1620

TGCAAAAGAA GCTGCTTGAT GCTCATGGAT GAATTTACGC TCTGTGGCTA TTTAGAGACC 1680

TTTGTTAAAG CGGTAGGGAT CATGGCAGAA TACAACATGC GCCCCGCTTT TGTGTTTCAA 1740

AGTAAGGCGC AATTAGAAAA CGACCCCCCA CTTGGTTATG GTAGGAATGG CGCTAAGACT 1800

ATTTTAGACA ACCTTTCTTT GAATATGTAT TATGGGATCA ACAACGATAA CTACTATGAA 1860

CATTTTGAAA AGCTTTCTAA AGTGTTAGGG AAATACACAA GGCAAGATGT GAGCCGGAGC 1920

ATTGATGATA ATACGGGTAA GACCAACACT TCTATCAGCA ACAAGGAGCG GTTTTTGATG 1980

ACCCCTGATG AATTGATGAC TATGGGCGAT GAGCTTATCA TTTTAGAAAA CACGCTCAAA 2040

CCCATCAAGT GCCACAAGGC GCTTTACTAT GATGATCCCT TCTTCACCGA TGAGCTCATT 2100

AAGGTGAGTC CAAGCTTGAG CAAGAAATAC AAATTGGGGA AAGTGCCTAA TCAAGCAACA 2160

TTTTATGATG ACTTGCAAGC CGCTAAAACC AGAGGCGAAT TGAGCTATGA TAAATCTTTA 2220 GTGCCTGTGG GTTCAAGCGA ACTGTGA 2247

(2) INFORMATION FOR SEQ ID NO: 1026:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1215 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...1215

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1026:

CTGAATGCAA AATCTCAATC CTCCCTAAAA AACAAAATCA CTCTTAAGAA TAAGCTAAAT 60

CATGCTAGAA TTATACTTGA ATTTATTCCT AGTTTAATTT ATTTCTTAAT ACAAAAGGTG 120

AGCGTTTTGA AACATTTAGC CCCACTCATT CATATCCCTT TTAAAGCCTT ATGGCTAGGC 180

ACAGCCTTAA GCATGTTCTT AAGTTTGAAT TTGAACGCTG AAGAAAACCC TACTAAAACA 240

GAGCCTAAGC CCGCTAAAGG GGTTAAAAAC AAGCCCAAAT CGCCTGTTAC TAATGTCATG 300

ATGACCAATT GCGATAACCT TAAAGACTTT AACGCTAAGC AAAAAGAAGT TTTAAAAGCC 360

GCTTATCAAT TCGGATCTAA AGAAAATTTA GGCTATGAAA TGGCGGGCAT TGCGTGGAAA 420

GAATCATGCG CAGGGACTTA TAAAATCAAT TTTTCGGATC CGAGTGCGGG CATTTACCAT 480

GCGTATATCC CTAGCGTTTT AAAAAGCTAT GGGCATAATA ATAGCCCCTT TTTGCGTAAC 540

GTGATGGGGG AATTGCTCAT TAAAGACGAT GCGTTTGCTT CTGAAGTGGC CCTAAAAGAA 600

TTGCTCTATT GGAAAACGCG CTACCATGAC AACCTAAAAG ACATGATCAA GTCTTACAAT 660

AAGGGCAGTC GTTGGGAAAA AAACGAGAAA GCTAACGCTG ATGCTGAAAA ATATTATGAA 720

GAGATACAAG ATAGAATCAG GCGTTTGAAA GAATCTAAAA TCTTTGACTC GCAGTCTAGT 780

AATGACCAAG AATTGCAAAA AAGCGCTAAT AGCAATTTGG ATCTAGACCC TATCGGCAAC 840

GCCATGCCCC AAACTTTAGC TCAAACAGAG ACCCAAAAAT CTCAAATAGA AAAATCTCAA 900

ATAGAGGAAG CTCAAACGCA AAAATCTCAA GAAATGAAAG AGGCAGCTAG CGAGCAAGCC 960

ATTAAGAAGC CGCTAGAAAA AGAAAAAGAT AAACCCATGT ATTTGGCTCA AATCAATAGT 1020

GCTGATTTCG CGCCCGCTAA AAAAAGCCCA AAAAAACCGG CTAAAGCGAG TCCAAAACGC 1080

TCCTCTAAAA ATAATATCAG CGTTAAAAGC AACACCAAAA CCGCTTCCAA AAATAAAGAA 1140

GTGTGCAAAA ATTGCTCTCC AGGGCAAAGG AATGCGATTT TAGCTAACCA TATCACCCTC 1200

ATGCAAGAGC TTTAA 1215

(2) INFORMATION FOR SEQ ID NO: 1027:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 813 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 813

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1027:

ATGAAAAAGT TTGTAGTGTT TAAAACGCTC TGTTTATCGG TAGTGTTAGG TAATAGTCTT 60

GTGGCAGCAG AAGGTAGCAC AGAAGTGCAA AAGCAATTGG AAAAGCCAAA AGATTATAAA 120

GCAGTGAAAG GCGAGAAAAA CGCTTGGTAT CTGGGGATTA GCTATCAAGT CGGTCAGGCT 180

TCACAAAGCG TTAAAAACCC CCCCAAAAGC AGTGAATTTA ACTATCCTAA GTTCCCTGTG 240

GGTAAAACCG ACTATCTGGC CGTTATGCAA GGCTTAGGGC TTACTGTGGG TTATAAGCAG 300

TTTTTCGGGG AGAAAAGATG GTTTGGTGCG CGCTATTACG GCTTTATGGA TTATGGGCAT 360

GCCGTGTTTG GAGCGAACGC TTTGACATCA GATAATGGTG GGGTGTGCAA ACTCAATGAG 420

CCATGCGCGA CCAAAGTAGG GACTATGGGC AATCTGTCTG ACATGTTCAC TTATGGTGTG 480

GGTATTGACA CTTTATACAA TGTCATTAAT AAGGAAGACG CGAGTTTTGG TTTCTTTTTT 540

GGGGCTCAAA TCGCGGGTAA CTCTTGGGGT AATACGACAG GGGCCTTTTT GGAAACTAAA 600

AGCCCTTATA AGCACACCTC CTATAGCCTT GATCCGGCGA TTTTCCAGTT CCTTTTTAAT 660

TTAGGGATTC GCACCCATAT TGGTCAGCAT CAAGAATTTG ACTTTGGCGT GAAGATTCCT 720

ACTATCAATG TTTATTATTT TAACCATGGG AACTTGAGCT TCACTTACCG CCGTCAATAC 780

AGCCTTTATG TAGGGTATCG TTACAATTTC TGA 813

(2) INFORMATION FOR SEQ ID NO: 1028:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 759 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...759

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1028:

ATGAAACCTT ATTTCAGTTT GGAGAAATTG GATTTATACC ATGGCGATGC GAGCGTTTTA 60

GAGACTTTTG AAAAAGGTTT TTATGATTTG TGCGTTACTT CACCGCCCTA TAATTTGAGT 120

ATTGAATACC AAGGGAGTAA TGATTTTAGG GCTTATGACG ATTATTTGAA TTGGTGTAAA 180

AATTGGCTTA AAAATTGTTA TTTTTGGGGT AAGGAACAGG CGAGGTTGTG TTTGAATGTC 240

CCTTTGGATA CGAATAAGCA TGGCAAGCAA AGTTTGGGGG CTGATATTAC TATAGTGGCT 300

AAAGAATGCG GTTGGAAATA CCAAAATACG ATTATTTGGA ATGAAAGCAA TATCTCAAGA 360 CGCACCGCTT GGGGGAGTTG GCTGCAAGCT AGCGCACCTT ATGCGATCGC TCCTGTGGAG 420

TTGATCGTTG TTTTTTATAA AAACGAATAC AAACGAAAAA AACAAACTTC TACGATGAGT 480

AGAGAGGAAT TTTTACTCTA CACGAACGGG CTTTGGAATT TTAGCGGTGA ATCCAAAAAG 540

CGCCTAAAGC ACCCAGCCCC ATTCCCAAGG GAATTACCCA GGCGTTGCAT CCAATTGTTT 600

TCTTTTTTGG AAGACACGAT TTTTGATCCC TTTAGCGGCT CTGGCACGAC TATTTTAGAG 660

GCCAACGCTT TAGGGCGTTT TAGCGTGGGT TTAGAGATTG AAAAAGAATA TTGCGAGTTG 720

TCTAAAAAGC GTATTTTAGA GAGTTTGTCG TTAGTGTGA 759

(2) INFORMATION FOR SEQ ID NO: 1029:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2778 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...2778

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1029:

TTAGTTATAA TATCGCTACT AACAACACTC AAGCTAAAAT CCATTAAGGA AATCAGTATT 60

AAAAAATTTA TTCTATCTTC TCTTGTTTTC GCATGTATCA ATACCGGCGT TGAAGCTTTA 120

GAAAATGACG GCTCTAAACC AAACGATTTG GCTTCTCCAA AAGAAACCCC AAAAGAGGCT 180

CAAAAAAATG AAGCTCAAAA CGAAACCTCT CAATCCAATC AAACGCCTAA AGAAATGAAA 240

GTCAAGTCCA TTTCTTATGT CGGGCTTTCT TACATGTCTG ACATGCTCGC TAATGAAATT 300

GCAAAGATTC GCGTGGGCGA TATGGTGGAT TCTAAAAAAA TAGACACCGC TGTTTTAGCT 360

TTGTTCAACC AAGGGTATTT TAAAGACGTT TATGCCACTT TTGAAAACGG CATTTTAGAG 420

TTTCATTTTG ATGAAAAAGC CAGGATTGCC GGGGTAGAAA TCAAGGGTTA TGGGACTGAA 480

AAGGAAAAAG ACGGCTTAAA ATCCCAAATG GGGATCAAAA AGGGCGACAC CTTTGATGAG 540

CAAAAATTAG AGCATGCTAA AACGGCTTTA AAAACGGCTT TAGAGGGGCA GGGCTATTAT 600

GGGAGCGTGG TGGAGGTGCG CACAGAAAAG GTCAGTGAGG GAGCGTTATT GATCGTGTTT 660

GATGTGAATA GGGGGGACAG TATTTATATC AAACAATCCA TTTATGAGGG AAGCGATAAA 720

TTAAAACGCC GTGTGATTGA ATCTTTGAGC GCGAACAAGC AGCGCGATTT CATGGGCTGG 780

ATGTGGGGCT TGAATGACGG GAAATTGCGC TTAGATCAAT TAGAATACGA TTCTTTGCGT 840

ATCCAAGATG TGTATATGCG TAGGGGTTAC TTAGACGCTC ATATTTCTTC GCCTTTTTTG 900

AAAACGGATT TTTCCACCCA TGACGCTAAG CTCCATTATA AGGTCAAAGA GGGGATCCAA 960

TACAGGATTT CAGATATTTT AATAGAGATT GACAACCCGG TAGTCCCCTT AAAAACCTTA 1020

GAAAAAGCGC TTAAAGTTAA AAGGAAAGAT GTCTTTAATA TTGAGCATTT AAGAGCGGAT 1080

GCGCAAATTT TAAAAACCGA AATCGCCGAT AAGGGCTATG CGTTTGCGGT GGTGAAGCCA 1140

GACTTGGATA AAGACGAAAA AAACGGGCTT GTGAAAGTCA TTTATCGTAT TGAAGTGGGC 1200

GATATGGTGC ATATCAATGA TGTCATCATT TCAGGGAACC AGCGCACGAG CGATAGGATC 1260

ATTAGGAGGG AATTGTTACT AGGGCCTAAA GATAAATACA ACTTGACCAA ACTGAGAAAT 1320

TCCGAAAATT CTTTGAGGCG TTTAGGGTTT TTCTCTAAAG TCAAGATTGA AGAAAAAAGG 1380

GTCAATAGCT CATTGATGGA TTTGTTAGTG AGCGTAGAAG AGGGGCGCAC CGGGCAGTTG 1440

CAATTCGGGT TGGGCTATGG CTCTTATGGA GGGCTCATGC TTAATGGGAG CGTGAGCGAA 1500

AGGAATCTTT TTGGCACAGG GCAAAGCATG AGCTTGTATG CTAACATTGC CACAGGGGGG 1560 GGTAGATCTT ATCCGGGCAT GCCAAAAGGG GCGGGGCGTA TGTTTGCCGG GAATTTGAGC 1620

TTGACTAATC CAAGGATTTT TGACAGCTGG TATAGCTCTA CGATCAATCT TTATGCGGAT 1680

TACAGGATAA GCTACCAATA CATCCAACAA GGCGGGGGCT TTGGGGTGAA TGTCGGGCGC 1740

ATGCTGGGTA ATAGAACCCA TGTGAGCTTA GGGTATAACT TGAATGTTAC CAAACTCCTT 1800

GGTTTCAGCA GCCCCTTATA CAACCGCTAC TATTCCTCTG TTAATGAAGT GGCCTCTCCA 1860

AGGCAATGTT CCACACCCGC ATCGGTGATT ATCAACCGCT TATCAGGCGG TAGAACTCCA 1920

TTGGTTCCTG AAAGCTGTTC TAGTCCTGGA GCGATCACCA CTTCACCAGA AATAAAAGGT 1980

ATTTGGGATA GGGATTACCA CACGCCTATC ACCAGTTCTT TCACCCTTGA TGTGAGCTAT 2040

GACAACACCG ATGATTATTA TTTCCCTAGA AATGGGGTTA TCTTTAGTTC CTATGCGACA 2100

ATGTCTGGTT TGCCAAGCTC TGGCACGCTC AATTCTTGGA ACGGGTTAGG CGGGAATGTC 2160

CGTAACACCA AAGTTTATGG TAAATTCGCC GCTTACCACC ATTTGCAAAA ATATTTATTG 2220

ATAGATTTGA TCGCTCGTTT TAAAACGCAA GGGGGCTATA TCTTTAGGTA TAACACCGAT 2280

GATTACTTGC CCTTAAACTC CACTTTCTAC ATGGGGGGCG TAACCACGGT GAGAGGCTTT 2340

AGGAACGGCT CAATCACACC TAAAGATGAG TTTGGCTTGT GGCTTGGAGG CGATGGGATT 2400

TTTACCGCTT CTACTGAATT GAGCTATGGG GTGTTAAAAG CGGCTAAAAT GCGTTTAGCG 2460

TGGTTTTTTG ACTTTGGTTT CTTAACCTTT AAAACCCCAA CTAGGGGGAG TTTCTTCTAT 2520

AACGCTCCCA CCACGACGGC GAATTTTAAA GATTATGGCG TTGTAGGGGC TGGGTTTGAA 2580

AGGGCGACTT GGAGGGCTTC TACAGGCTTA CAGATTGAAT GGATTTCGCC CATGGGGCCT 2640

TTGGTGTTGA TTTTCCCTAT AGCGTTTTTC AACCAATGGG GCGATGGCAA TGGCAAAAAA 2700

TGTAAAGGGC TGTGCTTTAA CCCTAACATG AACGATTACA CGCAACATTT TGAATTTTCT 2760

ATGGGAACAA GGTTTTAA 2778

(2) INFORMATION FOR SEQ ID NO: 1030:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 576 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 576

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1030:

ATGAAACAAC TATTTTTGAT TATTGGAGCC CCAGGGAGTG GTAAAACCAC TGACGCAGAG 60

CTTATCGCTA AGAATAACAG CGAAACAATC GCTCATTTTT CTACTGGGGA TTTACTCAGG 120

GCTGAGAGCG CTAAAAAGAC TGAGCGAGGC TTATTGATTG AGAAATTCAC TTCTCAAGGC 180

GAATTAGTGC CTTTAGAAAT TGTGGTAGAA ACGATCCTTT CAGCGATTAA AAGCTCTAGT 240

AAAGGGATCA TTTTAATTGA TGGCTATCCC AGGAGCGTGG AGCAAATGCA AGCTTTGGAT 300

AAGGAATTGA ACGCTCAAAA TGAAGTGATC TTAAAAAGCG TGATTGAAGT AGAAGTGAGC 360

GAAAACACCG CTAAAGAAAG GGTTTTAGGG CGCTCTAGGG GGGCTGATGA TAATGAAAGG 420

GTGTTTCATA ACCGCATGCG GGTGTTTTTA GATCCGTTGG TTGAAATCCA AAACTTCTAC 480

AAGGCCAAGC ATTTGCATAA AATTATCAAT GGTGAAAGAA GCATTGAAGA AATCGTGAAT 540

GAAATGCAAA AATATATTTT GTCTTTTGCA AATTAA 576

(2) INFORMATION FOR SEQ ID NO: 1031: (l) SEQUENCE CHARACTERISTICS

(A) LENGTH- 1023 base pairs

(B) TYPE nucleic acid

(C) STRANDEDNESS. double

(D) TOPOLOGY, circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL- NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...1023

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1031:

TTGAGTTCGT TATGGCTGAC AAACCCCTTA AATGCCCATG AAAAGAATGG CGCGTTTGTG 60

GGGATTAGCT TGGAAGTGGG TAGGGTCGAT CAAAAGACCA ACGCTTATAG AAACGGCGAG 120

TTGTTTCAAG TGCCTTTTGG CGATGTTTCG GCTAATGATG ATGGCAAAGT CCCTGATGGG 180

CAGACCGGTG GCTGTCAGCC AGCTTCAGGG ACTCCAGGAA CGCCAGGCTA TACTAAAGCT 240

AATTGCGTGG TCAATTGGAC TTCTCGCACC ATGCTTAGCA CCAATAAGGA CATTCCTGGC 300

CGTAACCAGC CGATGTATGG GCTAGGCGTG ATGACAGGGT ATAAGCATTT TGTGGGTAAA 360

AAAAGGTGGT TTGGGCTGCG TTATTATGGC TTTTTTGATT ACGGGCATAC CAATTTCTCT 420

AACTCTAGGG CCGCTAACGC CATATCGCCC TTTTATTTGA GCGATCAAAA AGCGGACATG 480

TATACTTATG GTTTTGGCAC AGACATGCTT TTTAACGTTA TAGACAAGCC TAAAGCCACG 540

GCCGGGTTTT TTGTGGGCGT GAATTTTGCG GGTAACACTT GGACTAATAA TCGTGTGGGG 600

TATTTTAAGG ACGGGTATGT TTATGGCGTC AATACGGACG CTGACGCTTA CATGACTAAC 660

GCTGATGGCA CGATCACATG CGGAGACACG ACGCCGGCGA GTTGTAATGT GGGGATTAAC 720

CCTAACAGCG TCTATACCAC AGGAAAATTA AACGCTAAAG TGAATCACAC GATTTTCCAA 780

TTTTTAGTGA ATGTGGGCAT TAGAACCAAT ATTTTTGAAC ACCATGGCAT TGAGTTTGGT 840

ATCAAAATCC CCACGCTCCC TAATTACTTT TTCAAAGGTT CTACTACTAT AAGAGCGAAA 900

AAACAAGGCC CACTAGAGAA TGGGAACCCG ACTACTATCA CCGGAGCAGA AACCAATTTC 960

AGCTTAACCC AAACCTTACG CCGTCAGTAT TCTATGTATT TGCGTTATGT TTATACTTTT 1020

TAA 1023

(2) INFORMATION FOR SEQ ID NO: 1032:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1587 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE.

(A) ORGANISM: Helicobacter pylori ( ix ) FEATURE :

(A) NAME/KEY: miscjeature

(B) LOCATION 1...1587

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1032:

ATGAAATTAA AAAAACGAAA AGTTGCGGCT ACATTGCTAA AGCGTTTGAC CTTGCCACTA 60

TTGTTCACTA CGGGTTCATT AGGGGCGGTT ACTTATGAAG TGCATGGGGA TTTTATCAAC 120

TTCTCCAAAG TGGGTTTTAA CCGTTCGCCT ATTAACCCTG TTAAAGGTAT CTATCCTACA 180

GAAACTTTTG TTAACCTTAC GGGTAAGCTA GAGGGGTCTG TGCATTTAGG TAGGGGATGG 240

ACCGTGAATG TAGGCGGTGT TTTGGGCGGA CAAGTTTATG ATAACACTAG GTATGATAGG 300

TGGGCAAAGG ATTTTACCCC CCCAAGCTAT TGGGATAAAA CTTCTTGCGG CACTGATTCT 360

TTGAGCCTTT GTATGAATGC GACTAAAATG TGGCAACAGC AAGGGCCAGG TGGTATCATT 420

GACCCTAGGG GTATTGGCTA TATGTATATG GGTGAGTGGA ACGGCTTGTT CCCTAATTAC 480

TATCCGGCTA ACGCCTACTT GCCCGGGCAT TCAAGGCGCT ATGAAGTTTA TAAAGCGAAT 540

CTTACCTATG ACAGCGACAG AGTCCATATG GTAATGGGGC GCTTTGATGT TACCGAGCAG 600

GAGCAAATGG ATTGGATTTA CCAATTGTTC CAAGGTTTTT ATGGGACTTT CAAGCTTACT 660

AAGAACATGA AATTCTTGCT CTTTAGCTCT TGGGGTCGTG GTATCGCTGA TGGTCAATGG 720

TTGTTCCCTA TCTATCGTGA AAAGCCTTGG GGTATTCATA AGGCGGGTAT TATTTATCGC 780

CCTACAAAGA ATCTAATGAT CCACCCTTAT GTGTATCTCA TCCCAATGGT AGGTACATTG 840

CCCGGTGCTA AAATAGAATA CGATACCAAT CCTGAGTTTA GCGGTAGAGG TATAAGGAAT 900

AAAACGACTT TCTATGTGTT GTATGACTAT CGTTGGAATA ACGCTGAATA CGGCCGTTAC 960

GCACCCGCTC GTTATAACAC TTGGGATCCG TTCTTGGATA ATGGTAAGTG GCGTGGCTTG 1020

CAAGGTCCTG GTGGTGCGAC GCTCTATTTG CACCACCACA TAGACATTAA CAACTACTTT 1080

GTGGTTGGTG GTGCTTACCT CAACATCGGT AACCCTAACA TGAACTTAGG TACTTGGGGT 1140

AACCCTGTGG CTCTTGATGG TATCGAACAA TGGGTCGGTG GCATCTACAG CTTAGGCTTT 1200

GCGGGGATTG ACAACATTAC CGATGCTGAT GCGTTCACTG AGTATGTTAA AGGTGGAGGT 1260

AAGCATGGTA AGTTCAGTTG GAGCGTTTAT CAGCGCTTCA CTACCGCACC AAGGGCTTTG 1320

GAATATGGTA TTGGTATGTA TCTAGACTAT CAGTTCAGCA AGCATGTTAA AGCGGGTCTC 1380

AAACTCGTGT GGTTAGAGTT CCAAATCCGT GCGGGTTACA ACCCTGGAAC CGGTTTCCTT 1440

GGGCCAAACG GTCAGCCGCT CAACTTGAAT AATGGTTTGT TTGAATCTTC GGCGTTCGCG 1500

CAAGGCCCTC AAAACATGGG TGGTATCGCA AAAAGCATTA CTCAAGACAG AAGCCATTTG 1560

ATGACACACA TCAGTTATAG TTTCTAA 1587

(2) INFORMATION FOR SEQ ID NO: 1033:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 705 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME / KEY : mi scjeature

( B ) LOCATION 1 . . . 705

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1033: ATGACAAAAA TTGCCATGGC TAATTTCAAA TCCGCTATGC CTGTTTTTAA AAGCCATGCG 60

TATTTAAAAG AATTGGAAAA AACTTTAAAG CCGCAGCATT TTGATAGGGT GTTTGTATTC 120

CCTGATTTTT TGGGGTTATT GCCTAACGCG TTTTTGCATT TCACTTTAGG AGCGCAAAAC 180

GCTTACCCTA GAGATTGTGG GGCTTTTACC GGTGAAATCA CTTCCAAACA TTTAGAAGAA 240

CTGAAAATCC ACACGCTTTT AATAGGGCAT AGCGAGAGGC GAGTGCTTTT AAAGGAAAGC 300

CCTAGCTTTT TGAAAGAAAA ATTTGATTTT TTTAAAGGTA AAAATTTTAA AATTGTCTAT 360

TGTATTGGCG AAGATTTAAC GACCAGAGAA AAGGGTTTTA GGGCTGTAAA GGAATTTTTA 420

AGCGAGCAAT TAGAAAATAT TGATCTTAAT TATTCCAATT TAATTGTGGC TTATGAGCCT 480

ATTTGGGCGA TTGGCACTAA AAAAAGCGCG TCTTTAGAAG ATATTTACCT CACGCATGGT 540

TTTTTAAAGC AAATCTTAAA TCAAAAAACG CCCTTATTGT ATGGGGGGAG CGTGAATGCG 600

CAAAACGCTA AAGAAATTTT AGGGATTGAT AGCGTGGATG GCTTATTGAT TGGGAGCGCG 660

TCTTTGGAAT TAGAAAATTT TAAAACAATC ATTTCATTTT TATAA 705

(2) INFORMATION FOR SEQ ID NO: 1034:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1398 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...1398

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1034:

ATGTTCATTT ATGATACCAA ATTAAAACAA AAAGTCCCTT TTGAGCCTTT AGTCCACAAT 60

AAGGCGAATA TTTATGTGTG TGGGCCTACG GTGTATGATG ACGCTCATTT AGGGCATGCC 120

AGGAGCGCGA TTGCTTTTGA TTTGTTGAGG CGCACGCTTG AATTGAGCGG CTATGAAGTG 180

GTGCTAGTAA GGAATTTCAC GGATATTGAC GATAAGATTA TCAATAAAGC CTTCAAAGAA 240

AACAAAAGCA TTCAAGAATT AAGCAGCATT TACATTGAAT CTTACACGAG GGATCTAAAC 300

GCTTTGAACG TGAAACAACC CAGCCTAGAG CCTAAAGCGA GCGAGTATTT AGACGCTATG 360

GTGCGCATGA TTGAAACGCT TTTAGAAAAA AATTTCGCTT ATAGAGTTTC TAATGGGGAT 420

ATTTATTTAG ACACGAGCAA GGACAAAGAT TACGGCTCTT TGAGCATGCA TAATAGCAGC 480

GTGGAATTTA GCCGTATCGG TTTGGTGCAA GAAAAACGGC TTGAGCAGGA TTTTGTGTTA 540

TGGAAAAGCT ATAAGGGGGA TAATGATGTG GGCTTTGATA GCCCTTTAGG CAAAGGGCGC 600

CCTGGCTGGC ACATAGAATG CTCTAGCATG GTTTTTGAAA CTTTAGCGCT CGCTAACGCC 660

CCTTATCAAA TTGATATTCA TGCTGGCGGA ACGGATTTGT TATTCCCCCA CCATGAAAAT 720

GAAGCGTGCC AAACCCGTTG TGCCTTTGGC GTGGAGATCG CTAAATACTG GATGCACAAT 780

GGCTTTGTGA ATATCAATAA CGAAAAAATG TCTAAAAGTT TAGGGAATAG CTTTTTCATT 840

AAAGACGCCC TCAAAAACTA TGATGGCGAG ATTTTGCGTA ATTACTTACT AGGGGTGCAT 900

TACCGCTCTG TTTTGAATTT CAATGAAGAA GACTTGTTAA TGAGTAAAAA ACGCTTGGAT 960

AAAATCTATC GTTTGAAACA GCGCGTTTTA GGGACTTTAG GAGGAATAAA TCCAAACTTT 1020

AAAAAAGAAA TTTTAGAATG CATGCAAGAT GATTTAAACG TTTCTAAAGC GTTGAGCGTT 1080

TTAGAAAGCA TGCTTTCTTC TACGAATGAA AAACTGGATC AAAACCCTAA AAACAAGGCT 1140

TTGAAAGGCG AAATTTTAGC GAATCTGAAA TTCATAGAAG AACTGCTTGG TATTGGGTTT 1200 AAAGACCCTA GCGCGTATTT CCAATTAGGC GTGAGCGAGA GCGAAAAACA AGAAATTGAA 1260

AACAAGATAG AAGAAAGAAA ACGTGCCAAA GAACAAAAAG ATTTTTTAAA AGCCGATAGC 1320

ATCAGAGAAG AGCTTTTACA ACAAAAAATC GCTTTGATGG ACACCCCACA AGGCACGATT 1380

TGGGAGAAGC TTTTTTAA 1398

(2) INFORMATION FOR SEQ ID NO: 1035:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3642 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...3642

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1035:

ATGAAACAAT TTAAAAAGAA ACCAAAAAAG ATAAAACGAT CGCATCAAAA TCAAAAAACA 60

ATCTTAAAGC GTCCTTTATG GCTTATGCCT TTACTGATTG GCGGGTTTGC TAGTGGGGTG 120

TATGCGGATG GAACAGACAT TTTGGGGCTT AGTTGGGGGG AAAAAAGCCA AAAGGTATGC 180

GTGCATCGTC CATGGTATGC TATATGGAGT TGCGATAAAT GGGAGGAAAA AACACAACAA 240

TTTACAGGAA ACCAACTCAT CACAAAAACT TGGGCAGGGG GTAATGCGGC TAACTACTAC 300

CACTCTCAAA ACAACCAAGA CATCACAGCC AATTTAAAAA ATGATAACGG CACTTATTTT 360

TTAAGCGGTC TGTATAACTA CACCGGAGGG GAATATAATG GGGGGAATTT AGACATTGAA 420

TTAGGCAGTA ACGCTACTTT TAATCTAGGT GCGAGTAGTG GGAATAGCTT CACTTCTTGG 480

TATCCTAATG GGCATACTGA TGTTACTTTT AGCGCTGGGA CTATCAATGT GAATAACAGC 540

GTAGAAGTGG GCAATCGTGT GGGATCGGGA GCTGGCACGC ACACCGGCAC AGCCACTTTA 600

AACTTGAACG CTAATAAGGT TACTATCAAT TCCAATATCA GCGCGTATAA AACTTCGCAA 660

GTGAATGTAG GCAATGCTAA CAGCGTTATT ACCATTAATT CGGTTTCTTT AAATGGGGAT 720

ACTTGCAGTT CTTTAGCTAG GGTGGGCGTA GGGGCTAATT GCTCCACTTC TGGGCCTAGC 780

TATTCTTTTA AAGGGACGAC TAACGCTACT AACACGACTT TTAGCAATTC AAGCGGCAGT 840

TTCACTTTTG AAGAGAACGC CACTTTTAGC GGGGCGAAAT TAAATGGGGG GGCATTCACT 900

TTCAATAAAA AGTTTAACGC TACCAATAAT ACCGCTTTTA ATAGCGGTAG TTTTACTTTT 960

AAAGGCACAA GCTCTTTTAA TGGTGCGAAT TTTAGTAACG CTTCCTATAC TTTTAATAAT 1020

CAAGCCACTT TCCAAAACAG CTCCTTTAAT GGGGGGACTT TTACTTTTAA TGACCAGACC 1080

AATCAAAGCA CCCAGCACCC CCAAATTCAA AACAGCTCTT TTAGCGGCAG TGCTACCACT 1140

CTTAAGGGTT TTGCGACTTT TGAGCAAGCC TTTAACAATT CAAACCACCA ACTAACGATA 1200

CAAAACGCTT CCTTTAATAA CGCTACTTTC AACAATACCG GTAAAATCAC TATAGAAAAA 1260

GATGCGAGCT TTAATAACAC TTCGTTCAAC ACTCCTGTTG ATACAAACAA CATGACTATT 1320

AGTGGTGGCG TTACTTTAAG CGGTAAAAAT GACTTGAAAA ATGGTGCAAC CCTTGATTTT 1380

GGGAGTTCTA AAATCACTCT CACTCAAGGG ACGACTTTCA ACCTCACAAG TTTAGGCAGT 1440

GAGAAGAGCG TAACGATTTT AAATTCTAGA GGTGGGATCA CTTACAATCA TCTTTTAAAC 1500

CATGCGATCA ATAGCTTGAC AAACGCCCTA AAAACGAACG AAAGCTCTTC AAAACCGCAA 1560

AGTTTCGCTC AAGGTTTGTG GGATATGATC ACTTACAATG GGGTTACCGG GCAGCTTTTG 1620

AATGAAAACG CTGCAACATC TAAACCCACT GACTCTTCGC CCTCTAAATC CTCTACAAAC 1680

TCTACGCAAG TCTATCAAGT GGGTTACAAA ATAGGGGATA CTATCTACAA ACTGCAAGAA 1740 ACTTTCAGCC ACAATTCCAT TATTATTCAG GCTTTAGAGA GCGGGACTTA CACGCCACCC 1800

CCTGTCATTA ACGGCTCCAA ATTTGACTTA TCCGCTTCAA ATTATATCAA TGCTGACATG 1860

CCTTGGTATA ACCATAAATA TTATATTCCT AAATCCCAAA ATTTTACAGA GAGCGGGACT 1920

TATTACTTGC CGAGCGTTCA AATATGGGGG AGCTACACTA ACTCGTTTAA ACAAACCTTT 1980

AGCGCAAGTA ATAGCAATCT GGTGATTGGG TATAACGCAA CATGGACTGA TCACAATGTT 2040

TCTTCTAGCG ACACGGTGGC TTTTGGGGAC ACTTCAGGGA GCGCTCTTAA TGGGCATTGC 2100

GGGCCTTGGC CCTATTACCA ATGCACAGGC ACGACTAACG GCACTTATAG CGCTTATCAT 2160

GTCTATATCA CAGCGAATCT GCGTTCTGGC AATCGTATAG GCACCGGTGG GGCAGCCAAT 2220

CTAATCTTTA ATGGGGTAGA TAGTATCAAT ATCGCTAACG CTACCATCAC GCAACATAAC 2280

GCCGGGGCTT ATTCAAGCTC TATGACTTTT TCCACGCAAA ACATGGACAA TTCGCAGAAT 2340

TTGAATGGCC TAAATTCTAA CGGCAAGCTT TTGGTGTATG GCACAACTTT CACTAACCAA 2400

GCCAAAGACG GGAAATTCAT TTTCAATGCA GGGCAAGCGA CTTTTGAAAA CACCAACTTT 2460

AATGGAGGGA GTTACCAATT CAGCGGCGAT AGCTTGAATT TTTCAAATAA CAACCAGTTC 2520

AATAGCGGTT CGTTTGAGAT TGGCGCAAAA AATACTATTT TTAATAACGC TAATTTTAAC 2580

AACAGCACTT CTTTTAATTT CAATAATTCT AGCGCGACCA CTTCGTTTGT GGGGGATTTC 2640

ACTAACGCTA ATTCAAATTT GCAAATCGCT GGGAACGCTG TTTTTGGGAA CTCTACTAAT 2700

GGCTCTCAAA ATACCGCTAA TTTTAATAAT ACCGGCTCTG TTAATATTGC AGGGAATGCA 2760

ACCTTTGATA ACGTGGTATT TAACAGCCCT ACGAACACGA GCGTGAAAGG GAAAGTTACT 2820

CTCAATAACA TCACTTTAAA AAACTTGAAC GCTCCTTTGT CTTTTGGCGA TGGGACGATT 2880

GTTTTTAGCG CTCATTCGGT GATTAATATT GGTGAAGCTA TCACAAATGG CAACCCTATC 2940

ACCCTTGTAA GCTCTTCTAA AGCAATTGAA TACAACGACG CTTTCAGTAA AAATCTATGG 3000

CAGCTCATCA ACTACCAAGG GCATGGGGCT AGCAGTGAAA AGCTCGTTTC TAGTGCGGGT 3060

AATGGCGTCT ATGATGTGGT GTATTCTTTC AACAACCAAA CCTACAATTT CCAAGAGGTT 3120

TTTTCACCCA ACAGCATTTC TATCCGGCGT TTGGGCGTTG GCATGGTGTT TGATTATGTG 3180

GATATGGAAA AATCGGATCG TTTGTATTAT CAAAACGCTC TCGGTTTTAT GACCTACATG 3240

CCTAATAGCT ATAACAATAA TTTAGGGAAT TTAAACAACA CCATTTACTA TTACGACAAC 3300

AGCATTGACT TTTATGCGAG CGGGAAAACT CTATTCACTA AAGCGGAATT TTCTCAAACG 3360

TTCACTGGGC AAAACAGCGC GATCGTTTTT GGGGCTAAAA ATATATGGAC GAGCGTAAGC 3420

GATGCGCCGC AATCTAATGT GATCATTCGC TTTGGGGACA ATAAGGGAGC AGGGAGTAAT 3480

GATGCGAGTG GGCATTGCTG GAATTTGCAA TGCATAGGCT TTATCACAGG GCATTATGAA 3540

GCGCAAAAGA TTTACATCAC CGGCAGTATT GAAAGCGGGA ACCGCATTTC TAGCGGTGGG 3600

GCGCGAGCCT TAATTTTAAC GGGCTTCAAG GCATTCTTTT AA 3642

(2) INFORMATION FOR SEQ ID NO: 1036:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1503 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...1503

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1036:

ATGGCTGAAT GGAAAACGGA CACAGAAGAA GTCAAAAAGG TTGTTGGAAG ATGCAGGGAA 60 TTTAAAAGAT CCCTGCAAGA AGAAAAATGC AGTCCATTTA TCAAAGACCT TGATAGTTAC 120

GCGCTAAAAA TCATAGTGGA GCGCAGAAAA ACTGAAATGC AATTGGAAAA AGCCATAGGA 180

GAATTAAAAA AAGCCAAAAG CAATGAAGAT GACGCTAAAG TTGCTTTAAG AGTCTTGCAA 240

GGTGCTTCTG TCGTCTCGTG GATTTGGCCT CCTGCTAGAA TAGCTGCTAC GGCAGCCATT 300

GTAGCCGCTG AAGCTGTTTT GAAATTTATG AAAGAAGACA CAGAAAAATG CAAAAGGAAT 360

GTGGAGCTAT TAGAACGAAT GCTTGAAATC TACTCGAATC AAGCCAAAGC GAGCGCGAAT 420

CTTATGAATC AAGCTTGGGA GGGCATTAAA AAGAGGTTGC ATTTTTATAC TGATAAGCAC 480

CAGGAATTTA TCAGGCGTTT GAAACAAGCG AGCGATGCGA TAGATAACGA ATACAACTTT 540

CCAACTCCAG GCGTTTTATT GGAATACGAT TTTGAACGGC CTGCTATCTC TTATACCCCT 600

AAAAAAAGCG TTTTTAATGA GCGCTTGAAG GATTTGAGGG AAAATTTTAG CGCTTCTTTA 660

TACGCTGATT TGAAAGACAA GATCCATCAT AACGCCTTGT CTAACGATGA TTTAGAACGC 720

ATGATAGCTT TTAGAGAGCA AGAATTTGAA AAGAGTTTAG AGGATTGGAT GGGTGCATAT 780

TCTTATGATG AAAACCCTAA CGATGAATTA GATCGCATGG CAATATCTAA AGAGCAGGAG 840

TTGGAAAAGA GTTTAGAGGA TTTGATGCCA AGCGTTTTAG GCGTGCCTTC TTATAACGAA 900

AGCTTGACTT TAGCCAAAAA TCGTTGCGTT AAAAACTTTA AGGAAGCTTT AGAAGGTTTT 960

ACAGAAAAAA TCAAAGAATC CCCTAACGAT TCAAACGCTA TCAATGAAGC CTTTGATAAT 1020

TTAGAAACAG AGTTAGAGCG CGCTACAGAA AATTTGAGTC AAAAAATCGA TCCCGTTTTA 1080

GAACGGAATG AAAATTATAC GCAAAAAGCG TTGGAGTATA GGGAGTTTTT AGAAAGCCGT 1140

AAAGAGAGCT TTATTGTAGA TGAAAAAAAC CCCTATCCGG AAGAAGTCAG CTTTAATGAA 1200

TGGCGTTGGG CGGAATTTGA TAGCGTTTTT AGCGCCATTG TGCCTTTAGA AGATTTAAAT 1260

AAAACCGCAT GCGCTCATCA TGCCCTAAAG GCTTTACAAG CTACGCTTAA AGACAACGAT 1320

TTGGGCTTTG ATGCGACAGA GTTGGAACAG ATCGCAAAAG GATTCATCCC TAGGGGGTAT 1380

TTGTGGCATT TTGACGCGAA TGTTTTAGGG AATTTAGCGC TGGTGAGAGA AGAGTTATTA 1440

TTAGGCGTGA AACACACGAA AGGATATTCA CTATGGACAG AATTTCTACA GAAACAGAAT 1500

TGA 1503

(2) INFORMATION FOR SEQ ID NO: 1037:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 245 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...245

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1037:

Met Gin Phe Gin Lys Thr Leu Ser Ser Leu Ser Leu Phe Leu Ser Leu

1 5 10 15

Ser Leu Phe Leu Ser Phe Ser He Ala Glu Glu Asn Gly Ala Tyr Ala

20 25 30

Ser Val Gly Phe Glu Tyr Ser He Ser His Ala Val Glu His Asn Asn

35 40 45

Pro Phe Leu Asn Gin Glu Arg He Gin Thr He Ser Asn Ala Gin Asn

50 55 60

Gin He Tyr Lys Leu Asn Gin He Glu Asn Glu He Thr Asn Met Gin 65 70 75 80

Asn Thr Phe Asn Tyr Thr Asn Asn Ala Leu Lys Asn Asn Ala Lys Leu 85 90 95

Thr Pro Thr Glu Met Gin Ala Glu Gin Tyr Tyr Leu Gin Ser Thr Leu

100 105 110

Gin Asn He Glu Lys He Val Met Leu Ser Gly Gly Val Ala Ser Asn

115 120 125

Pro Lys Leu Val Gin Ala Leu Glu Lys Met Gin Glu Pro He Thr Asn

130 135 140

Pro Leu Glu Leu Val Glu Asn Leu Lys Asn Leu Glu Leu Gin Phe Ser 145 150 155 160

Gin Ser Gin Asn Ser Met Leu Ser Ser Leu Ser Ser Gin He Ala Gin

165 170 175

He Ser Asn Ser Leu Asn Ala Leu Asp Pro Ser Ser Tyr Ser Lys Asn

180 185 190

Val Ser Ser Met Tyr Gly Val Gly Leu Ser Val Gly Tyr Lys His Phe

195 200 205

Phe Thr Lys Lys Lys Asn Gin Gly Phe Arg Tyr Tyr Leu Phe Tyr Asp

210 215 220

Tyr Gly Tyr Thr Asn Phe Gly Phe Val Gly Asn Gly Phe Asp Gly Leu 225 230 235 240

Gly Lys Met Asn Asn 245

(2) INFORMATION FOR SEQ ID NO: 1038:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 632 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...632

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 1038 :

Met Lys Pro Thr Asn Glu Pro Lys Lys Pro Phe Phe Gin Ser Pro He

1 5 10 15

Val Leu Ala Val Leu Gly Gly He Leu Leu He Phe Phe Leu Arg Ser

20 25 30

Phe Asn Ser Asp Gly Ser Phe Ser Asp Asn Phe Leu Ala Ser Ser Thr

35 40 45

Lys Asn Val Ser Tyr His Glu He Lys Gin Leu He Ser Asn Asn Glu

50 55 60

Val Glu Asn Val Ser He Gly Gin Thr Leu He Lys Ala Ser His Lys 65 70 75 80

Glu Gly Asn Asn Arg Val He Tyr He Ala Lys Arg Val Pro Asp Leu

85 90 95

Thr Leu Val Pro Leu Leu Asp Glu Lys Lys He Asn Tyr Ser Gly Phe

100 105 110

Ser Glu Ser Asn Phe Phe Thr Asp Met Leu Gly Trp Leu Met Pro He 115 120 125

Leu Val He Leu Gly Leu Trp Met Phe Met Ala Asn Arg Met Gin Lys

130 135 140

Asn Met Gly Gly Gly He Phe Gly Met Gly Ser Ala Lys Lys Leu He 145 150 155 160

Asn Ala Glu Lys Pro Asn Val Arg Phe Asn Asp Met Ala Gly Asn Glu

165 170 175

Glu Ala Lys Glu Glu Val Val Glu He Val Asp Phe Leu Lys Tyr Pro

180 185 190

Glu Arg Tyr Ala Asn Leu Gly Ala Lys He Pro Lys Gly Val Leu Leu

195 200 205

Val Gly Pro Pro Gly Thr Gly Lys Thr Leu Leu Ala Lys Ala Val Ala

210 215 220

Gly Glu Ala His Val Pro Phe Phe Ser Met Gly Gly Ser Ser Phe He 225 230 235 240

Glu Met Phe Val Gly Leu Gly Ala Ser Arg Val Arg Asp Leu Phe Glu

245 250 255

Thr Ala Lys Lys Gin Ala Pro Ser He He Phe He Asp Glu He Asp

260 265 270

Ala He Gly Lys Ser Arg Ala Ala Gly Gly Met He Ser Gly Asn Asp

275 280 285

Glu Arg Glu Gin Thr Leu Asn Gin Leu Leu Ala Glu Met Asp Gly Phe

290 295 300

Gly Ser Glu Asn Ala Pro Val He Val Leu Ala Ala Thr Asn Arg Pro 305 310 315 320

Glu He Leu Asp Pro Ala Leu Met Arg Pro Gly Arg Phe Asp Arg Gin

325 330 335

Val Leu Val Asp Lys Pro Asp Phe Asn Gly Arg Val Glu He Leu Lys

340 345 350

Val His He Lys Gly Val Lys Leu Ala Asn Asp Val Asn Leu Gin Glu

355 360 365

Val Ala Lys Leu Thr Ala Gly Leu Ala Gly Ala Asp Leu Ala Asn He

370 375 380

He Asn Glu Ala Ala Leu Leu Ala Gly Arg Asn Asn Gin Lys Glu Val 385 390 395 400

Lys Gin Gin His Leu Lys Glu Ala Val Glu Arg Gly He Ala Gly Leu

405 410 415

Glu Lys Lys Ser Arg Arg He Ser Pro Lys Glu Lys Lys He Val Ala

420 425 430

Tyr His Glu Ser Gly His Ala Val He Ser Glu Met Thr Lys Gly Ser

435 440 445

Thr Arg Val Asn Lys Val Ser He He Pro Arg Gly Met Ala Ala Leu

450 455 460

Gly Tyr Thr Leu Asn Thr Pro Glu Glu Asn Lys Tyr Leu Met Gin Lys 465 470 475 480

His Glu Leu He Ala Glu He Asp Val Leu Leu Gly Gly Arg Ala Ala

485 490 495

Glu Glu Val Phe Leu Glu Glu He Ser Thr Gly Ala Ser Asn Asp Leu

500 505 510

Glu Arg Ala Thr Asp He He Lys Gly Met Val Ser Tyr Tyr Gly Met

515 520 525

Ser Ser Val Ser Gly Leu Met Val Leu Glu Lys Gin Arg Asn Ala Phe

530 535 540

Leu Gly Gly Gly Tyr Gly Ser Ser Arg Glu Phe Ser Glu Lys Thr Ala 545 550 555 560

Glu Glu Met Asp Leu Phe He Lys Asn Leu Leu Glu Glu Arg Tyr Gin 565 570 575 His Val Lys Gin Thr Leu Ser Asp Tyr Arg Glu Ala He Glu He Met

580 585 590

Val Lys Glu Leu Phe Asp Lys Glu Val He Thr Gly Glu Arg Val Arg

595 600 605

Glu He He Ser Glu Tyr Glu Ala Ala Asn Asn Leu Glu Ser Arg Leu

610 615 620

He Pro Leu Glu Glu Gin Ala Ser 625 630

(2) INFORMATION FOR SEQ ID NO: 1039:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1288 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...1288

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 1039 :

Met Glu He Gin Gin Thr His Arg Lys He Asn Arg Pro Leu Val Ser

1 5 10 15

Leu Val Leu Ala Gly Ala Leu He Ser Ala He Pro Gin Glu Ser His

20 25 30

Ala Ala Phe Phe Thr Thr Val He He Pro Ala He Val Gly Gly He

35 40 45

Ala Thr Gly Thr Ala Val Gly Thr Val Ser Gly Leu Leu Ser Trp Gly

50 55 60

Leu Lys Gin Ala Glu Glu Ala Asn Lys Thr Pro Asp Lys Pro Asp Lys 65 70 75 80

Val Trp Arg He Gin Ala Gly Lys Gly Phe Asn Glu Phe Pro Asn Lys

85 90 95

Glu Tyr Asp Leu Tyr Lys Ser Leu Leu Ser Ser Lys He Asp Gly Gly

100 105 110

Trp Asp Trp Gly Asn Ala Ala Arg His Tyr Trp Val Lys Gly Gly Gin

115 120 125

Trp Asn Lys Leu Glu Val Asp Met Lys Asp Ala Val Gly Thr Tyr Lys

130 135 140

Leu Ser Gly Leu Arg Asn Phe Thr Gly Gly Asp Leu Asp Val Asn Met 145 150 155 160

Gin Lys Ala Thr Leu Arg Leu Gly Gin Phe Asn Gly Asn Ser Phe Thr

165 170 175

Ser Tyr Lys Asp Ser Ala Asp Arg Thr Thr Arg Val Asn Phe Asn Ala

180 185 190

Lys Asn He Ser He Asp Asn Phe Val Glu He Asn Asn Arg Val Gly

195 200 205

Ser Gly Ala Gly Arg Lys Ala Ser Ser Thr Val Leu Thr Leu Gin Ala 210 215 220 Ser Glu Gly He Thr Ser Ser Lys Asn Ala Glu He Ser Leu Tyr Asp 225 230 235 240

Gly Ala Thr Leu Asn Leu Ala Ser Asn Ser Val Lys Leu Asn Gly Asn

245 250 255

Val Trp Met Gly Arg Leu Gin Tyr Val Gly Ala Tyr Leu Ala Pro Ser

260 265 270

Tyr Ser Thr He Asn Thr Ser Lys Val Gin Gly Glu Val Asp Phe Asn

275 280 285

His Leu Thr Val Gly Asp Gin Asn Ala Ala Gin Ala Gly He He Ala

290 295 300

Ser Asn Lys Thr His He Gly Thr Leu Asp Leu Trp Gin Ser Ala Gly 305 310 315 320

Leu Asn He He Ala Pro Pro Glu Gly Gly Tyr Lys Asp Lys Pro Asn

325 330 335

Ser Thr Thr Ser Gin Ser Gly Thr Lys Asn Asp Lys Lys Glu He Ser

340 345 350

Gin Asn Asn Asn Ser Asn Thr Glu Val He Asn Pro Pro Asn Asn Thr

355 360 365

Gin Lys Thr Glu Thr Glu Pro Thr Gin Val He Asp Gly Pro Phe Ala

370 375 380

Gly Gly Lys Asp Thr Val Val Asn He Phe His Leu Asn Thr Lys Ala 385 390 395 400

Asp Gly Thr He Lys Val Gly Gly Phe Lys Ala Ser Leu Thr Thr Asn

405 410 415

Ala Ala His Leu Asn He Gly Lys Gly Gly Val Asn Leu Ser Asn Gin

420 425 430

Ala Ser Gly Arg Thr Leu Leu Val Glu Asn Leu Thr Gly Asn He Thr

435 440 445

Val Asp Gly Pro Leu Arg Val Asn Asn Gin Val Gly Gly Tyr Ala Leu

450 455 460

Ala Gly Ser Ser Ala Asn Phe Glu Phe Lys Ala Gly Val Asp Thr Lys 465 470 475 480

Asn Gly Thr Ala Thr Phe Asn Asn Asp He Ser Leu Gly Arg Phe Val

485 490 495

Asn Leu Lys Val Asp Ala His Thr Ala Asn Phe Lys Gly He Asp Thr

500 505 510

Gly Asn Gly Gly Phe Asn Thr Leu Asp Phe Ser Gly Val Thr Asp Lys

515 520 525

Val Asn He Asn Lys Leu He Thr Ala Ser Thr Asn Val Ala Val Lys

530 535 540

Asn Phe Asn He Asn Glu Leu He Val Lys Thr Asn Gly He Ser Val 545 550 555 560

Gly Glu Tyr Thr His Phe Ser Glu Asp He Gly Ser Gin Ser Arg He

565 570 575

Asn Thr Val Arg Leu Glu Thr Gly Thr Arg Ser He Phe Ser Gly Gly

580 585 590

Val Lys Phe Lys Ser Gly Glu Lys Leu Val He Asn Asp Phe Tyr Tyr

595 600 605

Ser Pro Trp Asn Tyr Phe Asp Ala Arg Asn Val Lys Asn Val Glu He

610 615 620

Thr Arg Lys Phe Ala Ser Ser Thr Pro Glu Asn Pro Trp Gly Thr Ser 625 630 635 640

Lys Leu Met Phe Asn Asn Leu Thr Leu Gly Gin Asn Ala Val Met Asp

645 650 655

Tyr Ser Gin Phe Ser Asn Leu Thr He Gin Gly Asp Phe He Asn Asn

660 665 670

Gin Gly Thr He Asn Tyr Leu Val Arg Gly Gly Lys Val Ala Thr Leu 675 680 685

Asn Val Gly Asn Ala Ala Ala Met Met Phe Asn Asn Asp He Asp Ser

690 695 700

Ala Thr Gly Phe Tyr Lys Pro Leu He Lys He Asn Ser Ala Gin Asp 705 710 715 720

Leu He Lys Asn Thr Glu His Val Leu Leu Lys Ala Lys He He Gly

725 730 735

Tyr Gly Asn Val Ser Thr Gly Thr Asn Gly He Ser Asn Val Asn Leu

740 745 750

Glu Glu Gin Phe Lys Glu Arg Leu Ala Leu Tyr Asn Asn Asn Asn Arg

755 760 765

Met Asp Thr Cys Val Val Arg Asn Thr Asp Asp He Lys Ala Cys Gly

770 775 780

Met Ala He Gly Asn Gin Ser Met Val Asn Asn Pro Asp Asn Tyr Lys 785 790 795 800

Tyr Leu He Gly Lys Ala Trp Arg Asn He Gly He Ser Lys Thr Ala

805 810 815

Asn Gly Ser Lys He Ser Val Tyr Tyr Leu Gly Asn Ser Thr Pro Thr

820 825 830

Glu Asn Gly Gly Asn Thr Thr Asn Leu Pro Thr Asn Thr Thr Asn Asn

835 840 845

Ala His Ser Ala Asn Tyr Ala Leu Val Lys Asn Ala Pro Phe Ala His

850 855 860

Ser Ala Thr Pro Asn Leu Val Ala He Asn Gin His Asp Phe Gly Thr 865 870 875 880

He Glu Ser Val Phe Glu Leu Ala Asn Arg Ser Lys Asp He Asp Thr

885 890 895

Leu Tyr Thr His Ser Gly Ala Gin Gly Arg Asp Leu Leu Gin Thr Leu

900 905 910

Leu He Asp Ser His Asp Ala Gly Tyr Ala Arg Gin Met He Asp Asn

915 920 925

Thr Ser Thr Gly Glu He Thr Lys Gin Leu Asn Ala Ala Thr Asp Ala

930 935 940

Leu Asn Asn Val Ala Ser Leu Glu His Lys Gin Ser Gly Leu Gin Thr 945 950 955 960

Leu Ser Leu Ser Asn Ala Met He Leu Asn Ser Arg Leu Val Asn Leu

965 970 975

Ser Arg Lys His Thr Asn His He Asn Ser Phe Ala Gin Arg Leu Gin

980 985 990

Ala Leu Lys Gly Gin Glu Phe Ala Ser Leu Glu Ser Ala Ala Glu Val

995 1000 1005

Leu Tyr Gin Phe Ala Pro Lys Tyr Glu Lys Pro Thr Asn Val Trp Ala

1010 1015 1020

Asn Ala He Gly Gly Ala Ser Leu Asn Ser Gly Ser Asn Ala Ser Leu 1025 1030 1035 1040

Tyr Gly Thr Ser Ala Gly Val Asp Ala Phe Leu Asn Gly Asn Val Glu

1045 1050 1055

Ala He Val Gly Gly Phe Gly Ser Tyr Gly Tyr Ser Ser Phe Ser Asn

1060 1065 1070

Gin Ala Asn Ser Leu Asn Ser Gly Ala Asn Asn Ala Asn Phe Gly Val

1075 1080 1085

Tyr Ser Arg Phe Phe Ala Asn Gin His Glu Phe Asp Phe Glu Ala Gin

1090 1095 1100

Gly Ala Leu Gly Ser Asp Gin Ser Ser Leu Asn Phe Lys Ser Thr Leu 1105 1110 1115 1120

Leu Gin Asp Leu Asn Gin Ser Tyr Asn Tyr Leu Ala Tyr Ser Ala Thr 1125 1130 1135 Ala Arg Ala Ser Tyr Gly Tyr Asp Phe Ala Phe Phe Arg Asn Ala Leu

1140 1145 1150

Val Leu Lys Pro Ser Val Gly Val Ser Tyr Asn His Leu Gly Ser Thr

1155 1160 1165

Asn Phe Lys Ser Asn Ser Gin Ser Gin Val Ala Leu Lys Asn Gly Ala

1170 1175 1180

Ser Ser Gin His Leu Phe Asn Ala Asn Ala Asn Val Glu Ala Arg Tyr 1185 1190 1195 1200

Tyr Tyr Gly Asp Thr Ser Tyr Phe Tyr Leu His Ala Gly Val Leu Gin

1205 1210 1215

Glu Phe Ala His Phe Gly Ser Asn Asp Val Ala Ser Leu Asn Thr Phe

1220 1225 1230

Lys He Asn Ala Ala Arg Ser Pro Leu Ser Thr Tyr Ala Arg Ala Met

1235 1240 1245

Met Gly Gly Glu Leu Gin Leu Ala Lys Glu Val Phe Leu Asn Leu Gly

1250 1255 1260

Val Val Tyr Leu His Asn Leu He Ser Asn Ala Ser His Phe Ala Ser 1265 1270 1275 1280

Asn Leu Gly Met Arg Tyr Ser Phe 1285

(2) INFORMATION FOR SEQ ID NO: 1040:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1484 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...1484

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1040:

Gly Ala Val Ser Leu Arg Gly Gin Phe Asn Leu Ser Asn Asn Ser Ser

1 5 10 15

Leu Asp Phe Gin Gly Ser Ser Ala He Thr Ser Asn Thr Ala Phe Asn

20 25 30

Phe Tyr Asp Asn Ala Phe Ser Gin Ser Pro He Thr Phe His Gin Ala

35 40 45

Leu Asp He Lys Val Pro Leu Ser Leu Gly Gly Asn Leu Leu Asn Pro

50 55 60

Asn Asn Ser Ser Val Leu Asn Leu Lys Asn Ser Gin Leu Val Phe Ser 65 70 75 80

Asp Gin Gly Ser Leu Asn He Ala Asn He Asp Leu Leu Ser Asp Leu

85 90 95

Asn Gly Asn Lys Asn Arg Val Tyr Asn He He Gin Ala Asp Met Asn

100 105 110

Gly Asn Trp Tyr Glu Arg He Asn Phe Phe Gly Met Arg He Asn Asp 115 120 125 Gly He Tyr Asp Ala Lys Asn Gin Thr Tyr Ser Phe Thr Asn Pro Leu

130 135 140

Asn Asn Ala Leu Lys He Thr Glu Ser Phe Lys Asn Asn Gin Leu Ser 145 150 155 160

Val Thr Leu Ser Gin He Pro Gly He Lys Asn Thr Leu Tyr Asn He

165 170 175

Gly Ser Glu He Phe Asn Tyr Gin Lys Val Tyr Asn Asn Ala Asn Gly

180 185 190

Val Tyr Ser Tyr Ser Asp Asp Ala Gin Gly Val Phe Tyr Leu Thr Ser

195 200 205

Ser Val Lys Gly Tyr Tyr Asn Pro Asn Gin Ser Tyr Gin Ala Ser Gly

210 215 220

Ser Asn Asn Thr Thr Lys Asn Asn Asn Leu Thr Ser Glu Ser Ser Val 225 230 235 240

He Ser Gin Thr Tyr Asn Ala Gin Gly Asn Pro He Ser Ala Leu His

245 250 255

Val Tyr Asn Lys Gly Tyr Asn Phe Ser Asn He Lys Ala Leu Gly Gin

260 265 270

Met Ala Leu Lys Leu Tyr Pro Glu He Lys Lys He Leu Gly Asn Asp

275 280 285

Phe Ser Leu Ser Ser Leu Ser Asn Leu Lys Gly Asp Ala Leu Asn Gin

290 295 300

Leu Thr Lys Leu He Thr Pro Ser Asp Trp Lys Asn He Asn Glu Leu 305 310 315 320

He Asp Asn Ala Asn Asn Ser Val Val Gin Asn Phe Asn Asn Gly Thr

325 330 335

Leu He He Gly Ala Thr Lys He Gly Gin Thr Asp Thr Asn Ser Ala

340 345 350

Val Val Phe Gly Gly Leu Gly Tyr Gin Lys Pro Cys Asp Tyr Thr Asp

355 360 365

He Val Cys Gin Lys Phe Arg Gly Thr Tyr Leu Gly Gin Leu Leu Glu

370 375 380

Ser He Ser Ala Asp Leu Gly Tyr He Asp Thr Thr Phe Asn Ala Lys 385 390 395 400

Glu He Tyr Leu Thr Gly Thr Leu Gly Ser Gly Asn Ala Trp Gly Thr

405 410 415

Gly Gly Ser Ala Ser Val Thr Phe Asn Ser Gin Thr Ser Leu He Leu

420 425 430

Asn Gin Ala Asn He Val Ser Ser Gin Thr Asp Gly He Phe Ser Met

435 440 445

Leu Gly Gin Glu Gly He Asn Lys Val Phe Asn Gin Ala Gly Leu Ala

450 455 460

Asn He Leu Gly Glu Val Ala Met Gin Ser He Asn Lys Ala Gly Gly 465 470 475 480

Leu Gly Asn Leu He Val Asn Thr Leu Gly Ser Asp Ser Val He Gly

485 490 495

Gly Tyr Leu Thr Pro Glu Gin Lys Asn Gin Thr Leu Ser Gin Leu Leu

500 505 510

Gly Gin Asn Asn Phe Asp Asn Leu Met Asn Asp Ser Gly Leu Asn Thr

515 520 525

Ala He Lys Asp Leu He Arg Gin Lys Leu Gly Phe Trp Thr Gly Leu

530 535 540

Val Gly Gly Leu Ala Gly Leu Gly Gly He Asp Leu Gin Asn Pro Glu 545 550 555 560

Lys Leu He Gly Ser Met Ser He Asn Asp Leu Leu Ser Lys Lys Gly

565 570 575

Leu Phe Asn Gin He Thr Gly Phe He Ser Ala Asn Asp He Gly Gin 580 585 590

Val He Ser Val Met Leu Gin Asp He Val Lys Pro Ser Asp Ala Leu

595 600 605

Lys Asn Asp Val Ala Ala Leu Gly Lys Gin Met He Gly Glu Phe Leu

610 615 620

Gly Gin Asp Thr Leu Asn Ser Leu Glu Ser Leu Leu Gin Asn Gin Gin 625 630 635 640

He Lys Ser Val Leu Asp Lys Val Leu Ala Ala Lys Gly Leu Gly Ser

645 650 655

He Tyr Glu Gin Gly Leu Gly Asp Leu He Pro Asn Leu Gly Lys Lys

660 665 670

Gly He Phe Ala Pro Tyr Gly Leu Ser Gin Val Trp Gin Lys Gly Asp

675 680 685

Phe Ser Phe Asn Ala Gin Gly Asn Val Phe Val Gin Asn Ser Thr Phe

690 695 700

Ser Asn Ala Asn Gly Gly Thr Leu Ser Phe Asn Ala Gly Asn Ser Leu 705 710 715 720

He Phe Ala Gly Asn Asn His He Ala Phe Thr Asn His Ser Gly Thr

725 730 735

Leu Asn Leu Leu Ser Asn Gin Val Ser Asn He Asn Val Thr Met Leu

740 745 750

Asn Ala Ser Asn Gly Leu Lys He Asn Ala Thr Asn Asn Asn Val Ser

755 760 765

Val Ser Gin Gly Asn Leu Phe He Asn Ala Ser Cys Val Gin Gin Ser

770 775 780

Asp Pro Thr Thr Ala Ser Ala Thr Asn Pro Cys Thr Thr Ala Gin Asn 785 790 795 800

Asn Ala Ser Ser Ser Asn Ala Ser Asn Asn Ala Pro He Ala Leu Asn

805 810 815

Asn Asn Asp Glu Ser Leu Val Val Thr Ala Asn Gly Phe Asn Phe Ser

820 825 830

Gly Asn He Tyr Ala Asn Gly Val Val Asp Phe Ser Lys He Lys Gly

835 840 845

Ser Ala Asn Val Lys Asn Leu Tyr Leu Tyr Asn Asn Ala Gin Phe Gin

850 855 860

Ala Asn Asn Leu Thr He Ser Asn Gin Ala Val Leu Glu Lys Asn Ala 865 870 875 880

Ser Phe Val Thr Asn Asn Leu Asn He Gin Gly Ala Phe Asn Asn Asn

885 890 895

Ala Thr Gin Lys He Glu Val Leu Gin Asn Leu Val He Ala Ser Asn

900 905 910

Ala Ser Leu Ser Thr Gly He Tyr Gly Leu Glu Val Gly Gly Ala Leu

915 920 925

Asn Asn Leu Gly Ala He His Phe Asn Leu Glu Asn Ser Gin Thr Pro

930 935 940

Val Asn Pro Leu He Gin Val Gly Gly He He Asn Leu Asn Thr Thr 945 950 955 960

Gin Thr Pro Phe Met Asn Val Ser Val Ala Asn Gly Gly Thr Tyr Thr

965 970 975

Leu Leu Lys Ser Ser Arg Tyr He Asp Tyr Asn He Asn Pro Asn Ser

980 985 990

Leu Gin Ser Tyr Leu Lys Leu Tyr Thr Leu He Asn He Asn Gly Asn

995 1000 1005

His He Glu Glu Lys Asn Gly Val Leu Thr Tyr Leu Gly Gin Arg Val

1010 1015 1020

Leu Leu Gin Asp Lys Gly Leu Leu Leu Ser Val Ala Leu Pro Asn Ser 1025 1030 1035 1040 Asn Asn Ala Ser Gin Asn Asn He Leu Ser Leu Ser Val Leu His Asn

1045 1050 1055

Gin He Lys Met Ser Tyr Gly Asn Lys Val Met Asp Phe Thr Pro Pro

1060 1065 1070

Thr Leu Gin Asp Tyr He Val Gly He Gin Gly Gin Ser Ala Leu Asn

1075 1080 1085

Gin He Glu Ala Val Gly Gly Asn Asn Ala He Lys Trp Leu Ser Thr

1090 1095 1100

Leu Met Met Glu Thr Lys Glu Asn Pro Leu Phe Ala Pro He Tyr Leu 1105 1110 1115 1120

Glu Asn His Ser Leu Asn Glu He Leu Gly Val Thr Lys Asp Leu Gin

1125 1130 1135

Asn Thr Ala Ser Leu He Ser Asn Pro Asn Phe Arg Asn Asn Ala Thr

1140 1145 1150

Ser Leu Leu Glu Met Ala Ser Tyr Thr Gin Gin Thr Ser Arg Leu Thr

1155 1160 1165

Lys Leu Ser Asp Phe Arg Ala Arg Glu Gly Glu Ser Asn Phe Ser Glu

1170 1175 1180

Arg Leu Leu Glu Leu Lys Asn Lys Arg Phe Ser Asp Pro Asn Pro Ser 1185 1190 1195 1200

Glu Val Phe Val Lys Tyr Ser Gin Leu Ser Lys His Pro Asn Asn Leu

1205 1210 1215

Trp He Gin Gly Val Gly Gly Ala Ser Phe He Ser Gly Gly Asn Gly

1220 1225 1230

Thr Leu Tyr Gly Leu Asn Val Gly Tyr Asp Arg Leu Val Lys Ser Val

1235 1240 1245

He Leu Gly Gly Tyr Val Ala Tyr Gly Tyr Ser Gly Phe Asn Gly Asn

1250 1255 1260

He Met His Ser Leu Ala Asn Asn Val Asp Val Gly Met Tyr Ala Arg 1265 1270 1275 1280

Ala Phe Leu Lys Arg Asn Glu Phe Thr Leu Ser Ala Asn Glu Thr Tyr

1285 1290 1295

Gly Gly Asn Ala Ser His He Asn Ser Ser Asn Ser Leu Leu Ser Val

1300 1305 1310

Leu Asn Gin Arg Tyr Asn Tyr Asn Thr Trp Thr Thr Ser Val Asn Gly

1315 1320 1325

Asn Tyr Gly Tyr Asp Phe Met Phe Lys Gin Lys Ser Val Val Leu Lys

1330 1335 1340

Pro Gin Val Gly Leu Ser Tyr His Phe He Gly Leu Ser Gly Met Lys 1345 1350 1355 1360

Gly Lys Met Gin Asn Pro Ala Tyr Gin Gin Phe Val Met His Ser Asn

1365 1370 1375

Pro Ser Asn Glu Ser Val Leu Thr Leu Asn Met Gly Leu Glu Ser Arg

1380 1385 1390

Lys Tyr Phe Gly Lys Asn Ser Tyr Tyr Phe Val Thr Ala Arg Leu Gly

1395 1400 1405

Arg Asp Leu Leu He Lys Ala Lys Gly Asp Asn Val Val Arg Phe Val

1410 1415 1420

Gly Glu Asn Thr Leu Leu Tyr Arg Lys Gly Glu He Phe Asn Thr Phe 1425 1430 1435 1440

Ala Ser Val He Thr Gly Gly Glu Met His Leu Trp Arg Leu Met Tyr

1445 1450 1455

Val Asn Ala Gly Val Gly Leu Lys Met Gly Leu Gin Tyr Gin Asp Leu

1460 1465 1470

Asn He Thr Gly Asn Val Gly Met Arg Val Ala Phe 1475 1480 (2) INFORMATION FOR SEQ ID NO: 1041:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 300 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...300

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 1041 :

Met Arg Lys Thr He Ser Ala Leu Phe Leu Ser Ala Cys He Gly Leu

1 5 10 15

Ser Ser Val His Ala Ser Asn Ala Leu He Leu Gin Thr Asp Phe Ser

20 25 30

Leu Lys Asp Gly Ala Val Ser Ala Met Lys Gly Val Ala Phe Ser Val

35 40 45

Asp Ser Asn Leu Lys He Phe Asp Leu Thr His Glu He Pro Pro Tyr

50 55 60

Asn He Trp Glu Gly Ala Tyr Arg Leu Tyr Gin Thr Ala Ser Tyr Trp 65 70 75 80

Pro Lys Gly Ser Val Phe Val Ser Val Val Asp Pro Gly Val Gly Thr

85 90 95

Asn Arg Lys Ser Val Val Leu Lys Thr Lys Asn Gly Gin Tyr Phe Val

100 105 110

Ser Pro Asp Asn Gly Thr Leu Thr Leu Val Ala Gin Thr Leu Gly He

115 120 125

Asp Ser Val Arg Glu He Asp Glu Lys Ala Asn Arg Leu Lys Gly Ser

130 135 140

Glu Lys Ser Tyr Thr Phe His Gly Arg Asp Val Tyr Ala Tyr Thr Gly 145 150 155 160

Ala Arg Leu Ala Ser Gly Ala He Thr Phe Glu Gin Val Gly Pro Glu

165 170 175

Leu Pro He Lys Val Val Glu He Pro Tyr Gin Lys Ala Lys Ala Thr

180 185 190

Lys Gly Gly Val Lys Gly Asn He Pro He Leu Asp He Gin Tyr Gly

195 200 205

Asn Val Trp Ser Asn He Ser Asp Lys Leu Leu Asn Gin Ala Gly He

210 215 220

Lys Arg Asn Asp Thr Val Cys Val Thr He Phe Lys Asn Ser Lys Lys 225 230 235 240

Gin Tyr Glu Gly Lys Met Pro Tyr Val Ala Ser Phe Gly Asp Val Pro

245 250 255

Glu Gly Gin Pro Leu Val Tyr Leu Asn Ser Leu Leu Asn Val Ser Val

260 265 270

Ala Leu Asn Met Asp Asn Phe Ala Gin Lys His Gin He Lys Ser Gly

275 280 285

Ala Asp Trp Asn He Asp He Lys Lys Cys Ala Lys 290 295 300

(2) INFORMATION FOR SEQ ID NO: 1042:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 526 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME / KEY : miscjeature

( B ) LOCATION 1 . . . 526

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 1042 :

Met Lys Leu Phe Asn Pro Arg Leu He Val Phe He Phe Ala Leu Leu

1 5 10 15

Leu Gly Val Gly Phe Ser Val Pro Ser Leu Leu Glu Thr Lys Gly Pro

20 25 30

Lys He Thr Leu Gly Leu Asp Leu Arg Gly Gly Leu Asn Met Leu Leu

35 40 45

Gly Val Gin Thr Asp Glu Ala Leu Lys Asn Lys Tyr Leu Ser Leu Ala

50 55 60

Ser Ala Leu Glu Tyr Asn Ala Lys Lys Gin Asn He Leu Leu Lys Asp 65 70 75 80

He Lys Ser Ser Leu Glu Gly He Ser Phe Glu Leu Leu Asp Glu Asp

85 90 95

Glu Ala Lys Lys Leu Asp Ala Leu Leu Leu Glu Leu Gin Gly His Ser

100 105 110

Gin Phe Glu He Lys Lys Glu Ala Glu Phe Tyr Ser Val Lys Leu Thr

115 120 125

Pro Leu Glu Gin Glu Glu Leu Arg Lys Asn Thr He Leu Gin Val He

130 135 140

Gly He He Arg Asn Arg Leu Asp Gin Phe Gly Leu Ala Glu Pro Val 145 150 155 160

Val He Gin Gin Gly Arg Glu Glu He Ser Val Gin Leu Pro Gly He

165 170 175

Lys Thr Leu Glu Glu Glu Arg Arg Ala Lys Asp Leu He Ser Lys Ser

180 185 190

Ala His Leu Gin Met Met Ala Val Asp Glu Glu His Asn Lys Asp Ala

195 200 205

Met Asn Met Thr Asp Leu Glu Ala Gin Lys Leu Gly Ser Val Leu Leu

210 215 220

Ser Asp Ala Glu Met Gly Gly Lys He Leu Leu Lys Ala He Pro He 225 230 235 240

Leu Asp Gly Glu Met Leu Thr Asp Ala Lys Val Val Tyr Asp Gin Asn

245 250 255

Asn Gin Pro Val Val Ser Phe Thr Leu Asp Ala Gin Gly Ala Lys He

260 265 270

Phe Gly Asp Phe Ser Gly Ala Asn Val Gly Lys Arg Met Ala He Val 275 280 285

Leu Asp Asn Lys Val Tyr Ser Ala Pro Val He Arg Glu Arg He Gly

290 295 300

Gly Gly Ser Gly Gin He Asn Gly Asn Phe Ser Val Ala Gin Ala Ser 305 310 315 320

Asp Leu Ala He Ala Leu Arg Ser Gly Ala Met Asn Ala Pro He Gin

325 330 335

Val Leu Glu Lys Arg He Val Gly Pro Ser Leu Gly Lys Asp Ser He

340 345 350

Lys Thr Ser He He Ala Leu Val Gly Gly Phe He Leu Val Met Gly

355 360 365

Phe Met Ala Leu Tyr Tyr Ser Met Ala Gly Val He Ala Cys Met Ala

370 375 380

Leu Val Val Asn Leu Phe Leu He Val Ala Val Met Ala He Phe Gly 385 390 395 400

Ala Thr Leu Thr Leu Pro Gly Met Ala Gly He Val Leu Thr Val Gly

405 410 415

He Ala Val Asp Ala Asn He He He Asn Glu Arg He Arg Glu Val

420 425 430

Leu Arg Glu Gly Glu Gly Val Val Lys Ala He His Leu Gly Tyr He

435 440 445

Asn Ala Ser Arg Ala He Phe Asp Ser Asn He Thr Ser Leu He Ala

450 455 460

Ser Val Leu Leu Tyr Ala Tyr Gly Thr Gly Ala He Lys Gly Phe Ala 465 470 475 480

Leu Thr Thr Gly He Gly He Leu Ala Ser He He Thr Ala He He

485 490 495

Gly Thr Gin Gly He Tyr Gin Ala Leu Leu Pro Lys Leu Ala Gin Thr

500 505 510

Lys Ser Leu Tyr Phe Trp Phe Gly Val Lys Asn Lys Arg Ala 515 520 525

(2) INFORMATION FOR SEQ ID NO: 1043:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 793 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...793

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 1043 :

He Met Asn Gly Tyr Leu Arg Val Lys Thr Pro Tyr Phe Leu Ala Ser

1 5 10 15

Val Val Leu Thr Phe Trp Thr Phe Asn Ser Phe Met Ser Ala Lys Asp

20 25 30

Lys His His Phe Leu Lys Lys Val Thr Thr Thr Glu Gin Lys Phe Ser 35 40 45

Ser Ser Ala Pro He Ser Trp Gin Ser Glu Glu Val Arg Asn Ser Thr

50 55 60

Ser Ser Arg Thr Val He Ser Asn Lys Glu Leu Lys Lys Thr Gly Asn 65 70 75 80

Leu Asn He Glu Asn Ala Leu Gin Asn Val Pro Gly He Gin He Arg

85 90 95

Asp Ala Thr Gly Thr Gly Val Leu Pro Lys He Ser Val Arg Gly Phe

100 105 110

Gly Gly Gly Gly Asn Gly His Ser Asn Thr Asn Met He Leu Val Asn

115 120 125

Gly He Pro He Tyr Gly Ala Pro Tyr Ser Asn He Glu Leu Ala He

130 135 140

Phe Pro Val Thr Phe Gin Ser Val Asp Arg He Asp Val He Lys Gly 145 150 155 160

Gly Thr Ser Val Gin Tyr Gly Pro Asn Thr Phe Gly Gly Val Val Asn

165 170 175

Val He Thr Lys Glu He Pro Lys Glu Trp Glu Asn Gin Ala Ala Glu

180 185 190

Arg He Thr Phe Trp Gly Arg Ser Ser Asn Gly Asn Phe Val Asp Pro

195 200 205

Lys Glu Lys Gly Lys Pro Leu Ala Gin Thr Leu Gly Asn Gin Met Leu

210 215 220

Phe Asn Thr Tyr Gly Arg Thr Ala Gly Met Leu Gly Lys Tyr He Gly 225 230 235 240

He Ser Ala Gin Gly Asn Trp He Asn Gly Gin Gly Phe Arg Gin Asn

245 250 255

Ser Pro Thr Lys Val Gin Asn Tyr Leu Leu Asp Ala He Tyr Lys He

260 265 270

Asn Ala Thr Asn Thr Phe Lys Ala Tyr Tyr Gin Tyr Tyr Gin Tyr Asn

275 280 285

Ser Tyr His Pro Gly Thr Leu Ser Ala Gin Asp Tyr Ala Tyr Asn Arg

290 295 300

Phe He Asn Glu Arg Pro Asp Asn Gin Asp Gly Gly Arg Ala Lys Arg 305 310 315 320

Phe Gly He Val Tyr Gin Asn Tyr Phe Gly Asp Pro Asp Arg Lys Val

325 330 335

Gly Gly Asp Phe Lys Phe Thr Tyr Phe Thr His Asp Met Ser Arg Asp

340 345 350

Phe Gly Phe Ser Asn Gin Tyr Gin Ser Val Tyr Met Ser Gly Gin Asn

355 360 365

Lys He Leu Pro Phe Lys Gly Lys Gly Glu He Ser Ala Lys Asn Pro

370 375 380

Asn Cys Gly Leu Tyr Ser Tyr Ser Asp Thr Asn Ser Pro Cys Trp Gin 385 390 395 400

Phe Phe Asp Asn He Arg Arg Ser Val Val Asn Ala Phe Glu Pro Lys

405 410 415

Leu Asn Leu He Val Asn Thr Gly Lys Val Lys Gin Thr Phe Asn Met

420 425 430

Gly Met Arg Phe Leu Thr Glu Asp Leu Tyr Arg Arg Ser Thr Thr Arg

435 440 445

Lys Asn Pro Ser Met Pro Asn Asn Gly Ser Gly Phe Asp Ala Gly Thr

450 455 460

Ser Leu Asn Asn Phe Asn Asn Tyr Thr Ala Val Tyr Ala Ser Asp Glu 465 470 475 480

He Asn Phe Asn Asn Gly Met Leu Thr He Thr Pro Gly Leu Arg Tyr 485 490 495 Thr Phe Leu Asn Tyr Glu Lys Lys Asp Ala Pro Pro Phe Lys Val Gly

500 505 510

Gin Thr Pro Lys Thr Thr Lys Glu Arg Tyr Asn Gin Trp Asn Pro Ala

515 520 525

Val Asn Val Gly Tyr Lys Pro He Lys Glu Leu Leu Phe Tyr Phe Asn

530 535 540

Tyr Gin Arg Ser Tyr He Pro Pro Gin Phe Ser Asn He Gly Asn Phe 545 550 555 560

Val Gly Thr Ser Thr Asp Tyr Phe Gin He Phe Asn Val Met Glu Gly

565 570 575

Gly Ser Arg Tyr Tyr Phe Asn His Gin Val Ser Phe Asn Ala Asn Tyr

580 585 590

Phe Val He Phe Ala Asn His Tyr Phe Thr Gly Arg Tyr Gly Asp Asn

595 600 605

Arg Glu Pro Val Asn Ala Arg Ser Gin Gly Val Glu Leu Glu Leu Tyr

610 615 620

Tyr Thr Pro He Arg Gly Leu Asn Phe His Ala Ala Tyr Thr Phe He 625 630 635 640

Asp Ala Asn He Thr Ser His Thr Met Val Thr Asn Pro Ala Asn Pro

645 650 655

Lys Gly Pro Lys Lys Asp He Phe Gly Lys Lys Leu Pro Phe Val Ser

660 665 670

Pro His Gin Phe He Leu Asp Ala Ser Tyr Thr Tyr Ala Lys Thr Thr

675 680 685

He Gly Leu Ser Ser Phe Phe Tyr Ser Arg Ala Tyr Ser Asp Val Leu

690 695 700

Asn Thr Val Pro Phe Thr Glu Tyr Ala Pro Thr He Lys Asn Gly Ala 705 710 715 720

He Val Thr Lys Thr Ala Gly Met Thr Pro Tyr Tyr Trp Val Trp Asn

725 730 735

Leu Gin He Ser Thr Thr Leu Trp Glu Arg Lys Asn Gin Ser Val Asn

740 745 750

Ala Ser Leu Gin He Asn Asn He Phe Asn Met Lys Tyr Trp Phe Ser

755 760 765

Gly He Gly Thr Ser Pro Asn Gly Lys Glu Ala Ala Pro Pro Arg Ser

770 775 780

He Thr Ala Tyr Val Ser Tyr Asn Phe 785 790

(2) INFORMATION FOR SEQ ID NO: 1044:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 333 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...333 ( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 1044 :

Met Leu He Ala Arg Phe Lys Lys Ala Leu He Ser Tyr Ser Leu Gly

1 5 10 15

Val Leu Leu Val Ser Ser Leu Leu Gly Val Ala Asn Ala Ser Asn Gin

20 25 30

Glu He Gin Val Lys Asp Tyr Phe Gly Glu Gin Thr He Lys Leu Pro

35 40 45

Val Ser Lys He He Tyr Leu Gly Ser Phe Ala Glu Val Pro Ala Met

50 55 60

Phe Asn Thr Trp Asp Arg Val Val Gly He Ser Asp Tyr Ala Phe Lys 65 70 75 80

Ser Asp He Val Lys Ala Thr Leu Lys Asp Pro Glu Arg He Lys Pro

85 90 95

Met Ser Ser Asp His Val Ala Ala Leu Asn Val Glu Leu Leu Lys Lys

100 105 110

Leu Ser Pro Asp Leu Val Val Thr Phe Val Gly Asn Pro Lys Ala Val

115 120 125

Glu His Ala Lys Lys Phe Gly He Ser Phe Leu Ser Phe Gin Glu Lys

130 135 140

Thr He Val Glu Val Met Glu Asp He Asp Ala Gin Ala Lys Ala Leu 145 150 155 160

Glu Val Asp Ala Ser Lys Lys Leu Ala Lys Met Gin Glu Thr Leu Asp

165 170 175

Phe He Lys Glu Arg Leu Lys Asn Val Lys Lys Lys Lys Gly Val Glu

180 185 190

Leu Phe His Lys Ala Asn Lys He Ser Gly His Gin Ala Leu Asp Ser

195 200 205

Asp He Leu Glu Lys Gly Gly He Asp Asn Phe Gly Leu Lys Tyr Val

210 215 220

Lys Phe Gly Arg Ala Asp He Ser Val Glu Lys He Val Lys Glu Asn 225 230 235 240

Pro Glu He He Phe He Trp Trp He Ser Pro Leu Ser Pro Glu Asp

245 250 255

Val Leu Asn Asn Pro Lys Phe Ser Thr He Lys Ala He Lys Asn Lys

260 265 270

Gin Val Tyr Lys Leu Pro Thr Met Asp He Gly Gly Pro Arg Ala Pro

275 280 285

Leu He Ser Leu Phe He Ala Leu Lys Ala His Pro Glu Ala Phe Lys

290 295 300

Gly Val Asp He Asn Ala He He Lys Asp Tyr Tyr Lys Val Val Phe 305 310 315 320

Asp Leu Asn Asp Ala Glu Val Glu Pro Phe Leu Trp His 325 330

(2) INFORMATION FOR SEQ ID NO: 1045:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 400 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE: (A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...400

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 1045 :

Met Tyr Lys Leu Gly He Phe Leu Leu Ala Thr Leu Leu Ser Ala Asn

1 5 10 15

Thr Gin Lys Val Ser Asp He Ala Lys Asp He Gin His Lys Glu Thr

20 25 30

Leu Leu Lys Lys Thr His Glu Glu Lys Asn Gin Leu Asn Ser Arg Leu

35 40 45

Ser Ser Leu Gly Glu Ala He Arg Ser Lys Glu Leu Gin Lys Val Glu

50 55 60

He Glu Arg Gin Met Val Ala Leu Lys Lys Ser Leu Glu Lys Asn Arg 65 70 75 80

Asn Glu Ser Leu Val Gin Glu Lys Val Leu Thr Asn Tyr Arg Lys Ser

85 90 95

Leu Asp His Leu Gin Lys Gin Arg Ser Phe Leu Gin Lys Arg Val Phe

100 105 110

Asp Thr Leu Leu Glu Asp Phe Leu Phe Ser Gin Ala Leu Lys Gly Gin

115 120 125

Asn Leu Ala Ser Ser Asn Asp Val He Leu Gin Val Ala Phe Glu Asn

130 135 140

Leu His Gin Ser Thr Leu Ser Lys Met Ser Gin Leu Ser Gin Glu Glu 145 150 155 160

Lys Lys Leu Asn Val Gin Ala Leu Glu Val Lys Ser Ser He Gin Lys

165 170 175

He Ser Ser Val He Asp Glu Gin Lys Thr Arg Glu Ser Thr Leu Lys

180 185 190

Ser Leu Gin Thr Glu Gin Asn Lys Leu He Leu Ser Met Gin Lys Asp

195 200 205

Tyr Ala He Tyr Asn Gin Arg Leu Ser Leu Leu Glu Lys Glu Arg Gin

210 215 220

Asn Leu Asn Ala Leu Leu Lys Arg Leu Asn He He Lys Gin Asn Arg 225 230 235 240

Glu Asn Glu Glu Arg Val Ser Leu Lys Lys Ser Ser Gin Ala Leu Glu

245 250 255

Val Lys Gin Val Ala Ser Ser Tyr Gin Asn He Asn Thr Thr Ser Tyr

260 265 270

Asn Gly Pro Lys Thr He Ala Pro Leu Asn Asp Tyr Glu Val Val Gin

275 280 285

Lys Phe Gly Pro Tyr He Asp Pro Val Tyr Asn Leu Lys He Phe Ser

290 295 300

Glu Ser He Thr Leu Val Ser Lys Thr Pro Asn Ala Leu Val Arg Asn 305 310 315 320

Val Leu Asp Gly Lys He Val Phe Ala Lys Glu He Asn Met Leu Lys

325 330 335

Lys Val Val He He Glu His Lys Asn Gly He Arg Thr He Tyr Ser

340 345 350

Gin Leu Asp Lys He Ala Pro Thr He Lys Ser Gly Met Arg He Gin

355 360 365

Lys Gly Tyr Val Leu Gly Arg He Asp Gin Arg Leu Gly Phe Glu Val

370 375 380

Thr Met Arg Glu Lys His He Asn Pro Leu Glu Leu He Ala Arg Asn 385 390 395 400

(2) INFORMATION FOR SEQ ID NO: 1046:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 549 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL : YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...549

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 1046 :

Met Asp Lys Asn Asn Asn Asn Asn Leu Arg Leu He Leu Ala He Ala

1 5 10 15

Leu Ser Phe Leu Phe He Ala Leu Tyr Ser Tyr Phe Phe Gin Glu Pro

20 25 30

Asn Lys Thr Thr Thr Glu Thr Thr Lys Gin Glu Thr Thr Asn Asn His

35 40 45

Thr Ala Thr Ser Pro Thr Ala Ser Asn Thr He Thr Gin Asp Phe Ser

50 55 60

Val Thr Gin Thr He Pro Gin Glu Ser Leu Leu Ser Thr He Ser Phe 65 70 75 80

Glu His Ala Lys He Glu He Asp Ser Leu Gly Arg He Lys Gin Val

85 90 95

Tyr Leu Lys Asp Lys Lys Tyr Leu Thr Pro Lys Glu Lys Gly Phe Leu

100 105 110

Glu His Val Ser His Leu Phe Ser Ser Lys Glu Asn Ser Gin Pro Ser

115 120 125

Leu Lys Glu Leu Pro Leu Leu Ala Ala Asp Lys Leu Lys Pro Leu Glu

130 135 140

Val Arg Phe Leu Asp Pro Thr Leu Asn Asn Lys Ala Phe Asn Thr Pro 145 150 155 160

Tyr Ser Ala Ser Lys Thr Thr Leu Gly Pro Asn Glu Gin Leu Val Leu

165 170 175

Thr Gin Asp Leu Gly Thr Leu Ser He He Lys Thr Leu Thr Phe Tyr

180 185 190

Asp Asp Leu His Tyr Asp Leu Lys He Ala Phe Lys Ser Pro Asn Asn

195 200 205

Leu He Pro Ser Tyr Val He Thr Asn Gly Tyr Arg Pro Val Ala Asp

210 215 220

Leu Asp Ser Tyr Thr Phe Ser Gly Val Leu Leu Glu Asn Thr Asp Lys 225 230 235 240

Lys He Glu Lys He Glu Asp Lys Asp Ala Lys Glu He Lys Arg Phe

245 250 255

Ser Asn Thr Leu Phe Leu Ser Ser Val Asp Arg Tyr Phe Thr Thr Leu

260 265 270

Leu Phe Thr Lys Asp Pro Gin Gly Phe Glu Ala Leu He Asp Ser Glu 275 280 285

He Gly Thr Lys Asn Pro Leu Gly Phe He Ser Leu Lys Asn Glu Ala

290 295 300

Asn Leu His Gly Tyr He Gly Pro Lys Asp Tyr Arg Ser Leu Lys Ala 305 310 315 320

He Ser Pro Met Leu Thr Asp Val He Glu Tyr Gly Leu He Thr Phe

325 330 335

Phe Ala Lys Gly Val Phe Val Leu Leu Asp Tyr Leu Tyr Gin Phe Val

340 345 350

Gly Asn Trp Gly Trp Ala He He Leu Leu Thr He He Val Arg He

355 360 365

He Leu Tyr Pro Leu Ser Tyr Lys Gly Met Val Ser Met Gin Lys Leu

370 375 380

Lys Glu Leu Ala Pro Lys Met Lys Glu Leu Gin Glu Lys Tyr Lys Gly 385 390 395 400

Glu Pro Gin Lys Leu Gin Ala His Met Met Gin Leu Tyr Lys Lys His

405 410 415

Gly Ala Asn Pro Leu Gly Gly Cys Leu Pro Leu He Leu Gin He Pro

420 425 430

Val Phe Phe Ala He Tyr Arg Val Leu Tyr Asn Ala Val Glu Leu Lys

435 440 445

Ser Ser Glu Trp Val Leu Trp He His Asp Leu Ser He Met Asp Pro

450 455 460

Tyr Phe He Leu Pro Leu Leu Met Gly Ala Ser Met Tyr Trp His Gin 465 470 475 480

Ser Val Thr Pro Asn Thr Met Thr Asp Pro Met Gin Ala Lys He Phe

485 490 495

Lys Leu Leu Pro Leu Leu Phe Thr He Phe Leu He Thr Phe Pro Ala

500 505 510

Gly Leu Val Leu Tyr Trp Thr Thr His Asn He Leu Ser Val Leu Gin

515 520 525

Gin Leu He He Asn Lys Val Leu Glu Asn Lys Lys Arg Ala His Ala

530 535 540

Gin Asn He Lys Glu 545

(2) INFORMATION FOR SEQ ID NO: 1047:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 479 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...479

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1047: Met Lys Lys Ser Leu Cys Leu Ser Phe Phe Leu Thr Phe Ser Asn Pro 1 5 10 15

Leu Gin Ala Leu Val He Glu Leu Leu Glu Glu He Lys Thr Ser Pro

20 25 30

His Lys Gly Thr Phe Lys Ala Lys Val Leu Asp Ser Lys Glu Pro Arg

35 40 45

Gin Val Leu Gly Val Tyr Asn He Ser Pro His Lys Lys Leu Thr Leu

50 55 60

Thr He Thr His He Ser Thr Ala He Val Tyr Gin Pro Leu Asp Glu 65 70 75 80

Lys Leu Ser Leu Glu Thr Thr Leu Ser Pro Asn Arg Pro Thr He Pro

85 90 95

Arg Asn Thr Gin He Val Phe Ser Ser Lys Glu Leu Lys Glu Pro His

100 105 110

Ser Asn Pro He Pro Ser Leu Asn Ala Pro Met Gin Lys Pro Gin Asn

115 120 125

Lys Pro Ser Ser Ser Gin Gin Ser Pro Gin Asn Phe Ser Tyr Pro Glu

130 135 140

Ser Lys Leu Gly Ser Lys Asn Ser Lys Asn Ser Leu Leu Gin Pro Leu 145 150 155 160

Val Thr Pro Ser Lys Val Ser Pro Thr Asn Glu Val Lys Thr Pro Thr

165 170 175

Asn Asp Ala Asn Pro Pro Leu Lys His Ser Ser Gin Asp Gin Glu Asn

180 185 190

Asn Leu Phe Val Ala Pro Pro Thr Glu Lys Thr Leu Pro Asn Asn Thr

195 200 205

Ser Ser Ala Asp Ala Ser Glu Asn Asn Glu Ser Asn Glu Asn Arg Asp

210 215 220

Asn Val Glu Lys Gin Ala He Arg Asp Pro Asn He Lys Glu Phe Ala 225 230 235 240

Cys Gly Lys Trp Val Tyr Asp Asp Glu Asn Leu Gin Ala Tyr Arg Pro

245 250 255

Ser He Leu Lys Arg Val Asp Lys Asp Lys Glu He Thr Thr Asp He

260 265 270

Thr Pro Cys Asp Tyr Ser Thr Ala Glu Asn Lys Ser Gly Lys He He

275 280 285

Thr Pro Tyr Thr Lys He Ser Val His Lys Thr Glu Pro Leu Glu Asp

290 295 300

Pro Gin Thr Phe Glu Ala Lys Asn Asn Phe Ala He Leu Gin Ala Arg 305 310 315 320

Ser Ser Thr Glu Lys Cys Lys Arg Ala Arg Ala Arg Lys Asp Gly Thr

325 330 335

Thr Arg Gin Cys Tyr Leu He Glu Glu Pro Leu Lys Gin Ala Trp Glu

340 345 350

Ser Glu Tyr Glu He Thr Thr Gin Leu Val Lys Ala He Tyr Glu Arg

355 360 365

Pro Lys Gin Asp Asp Gin Val Glu Pro Thr Phe Tyr Glu Thr Ser Glu

370 375 380

Leu Ala Tyr Ser Ser Thr Arg Lys Ser Glu He Thr Arg Asn Glu Leu 385 390 395 400

Asn Leu Asn Glu Lys Phe Met Glu Phe Val Glu Val Tyr Glu Gly His

405 410 415

Tyr Leu Asn Asp He He Lys Glu Ser Ser Glu Tyr Lys Glu Trp Val

420 425 430

Lys Asn His Val Arg Phe Lys Glu Gly Val Cys Met Ala Leu Glu He

435 440 445

Glu Glu Gin Pro Arg Ala Lys Ser Thr Pro Leu Ser He Glu Asn Ser 450 455 460 Arg Val Val Cys Val Lys Lys Gly Asn Tyr Leu Phe Asn Glu Val 465 470 475

(2) INFORMATION FOR SEQ ID NO: 1048:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 269 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...269

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 1048 :

Val Lys Val Tyr Pro Gin Val Leu Ser He Ala Gly Ser Asp Ser Gly

1 5 10 15

Gly Gly Ala Gly He Gin Ala Asp Leu Lys Ala Phe Gin Thr Phe Gly

20 25 30

Val Phe Gly Thr Ser Val He Thr Cys He Thr Ala Gin Asn Thr Gin

35 40 45

Gly Val His Gly Val Tyr Pro Leu Ser Val Glu Ser Val Lys Ala Gin

50 55 60

He Leu Ala He Arg Asp Asp Phe Ser He Lys Ala Phe Lys Met Gly 65 70 75 80

Ala Leu Cys Asn Ala Gin He He Glu Cys Val Ala Asn Ala Leu Glu

85 90 95

Thr Cys Asp Phe Gly Leu Cys Val Leu Asp Pro Val Met Val Ala Lys

100 105 110

Asn Gly Ala Leu Leu Leu Glu Glu Glu Ala He Leu Ser Leu Lys Lys

115 120 125

Arg Leu Leu Pro Lys Thr Asn Leu Leu Thr Pro Asn Leu Pro Glu Val

130 135 140

Tyr Ala Leu Thr Gly Val Gin Ala Arg Asp Asp Lys Ser Ala Ser Lys 145 150 155 160

Ala Met Gly Val Leu Arg Asp Leu Gly Val Lys Asn Ala Val He Lys

165 170 175

Gly Gly His Thr Glu His Phe Gin Gly Glu Phe Ser Asn Asp Trp Val

180 185 190

Phe Leu Glu Asp Ala Glu Phe He Leu Ser Ala Lys Arg Phe Asn Thr

195 200 205

Lys Asn Thr His Gly Thr Gly Cys Thr Leu Ser Ser Leu He Val Gly

210 215 220

Leu Leu Ala Gin Gly Leu Asp Leu Lys Asn Ala He Thr Lys Ala Lys 225 230 235 240

Glu Leu Leu Thr He He He Gin Asn Pro Leu Asn He Gly His Gly

245 250 255

His Gly Pro Leu Asn Leu Trp Ser He Lys Lys His Val 260 265 (2) INFORMATION FOR SEQ ID NO: 1049:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 398 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 398

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 1049 :

Leu Gly Ala He Met Asp Thr Phe Leu Thr Ser He Leu Val Leu Leu

1 5 10 15

Met Arg Gly Leu Leu Asn Gin Arg Ala He Met Gin Gly Leu Met Trp

20 25 30

Trp He Pro Leu Phe Tyr Asp Thr He Thr Lys Asp Val Phe Gly Phe

35 40 45

Lys Ala Gly Arg Tyr Glu Ala Asn He Asp Phe Met Ser Gly Ser Asn

50 55 60

Gin Gly Trp Glu Val Tyr Tyr Gin Pro Tyr Lys Thr Glu Thr Gin Arg 65 70 75 80

Leu Arg Phe Trp Trp Trp Ser Ser Phe Gly Arg Gly Leu Ala Phe Asn

85 90 95

Ser Trp He Tyr Glu Phe Phe Ala Thr Val Pro Tyr Leu Lys Lys Gly

100 105 110

Gly Asn Pro Ser Asn Ser Asn Asp Phe He Asn Tyr Gly Trp His Gly

115 120 125

He Thr Thr Thr Tyr Ser Tyr Lys Gly Leu Asp Ala Gin Phe Phe Tyr

130 135 140

Tyr Phe Ala Pro Lys Thr Tyr Asn Ala Pro Gly Phe Lys Leu Val Tyr 145 150 155 160

Asp Thr Asn Arg Asn Phe Glu Asn Val Gly Phe Arg Ser Gin Ser Met

165 170 175

He Met Thr Thr Phe Pro Leu Tyr Tyr Arg Gly Trp Tyr Asn Pro Glu

180 185 190

Thr Asn Thr Tyr Ser Leu Glu Asp Ser Thr Pro His Gly Ser Leu Leu

195 200 205

Gly Arg Asn Gly Val Thr Leu Asn He Arg Gin Val Phe Trp Trp Asp

210 215 220

Asn Phe Asn Trp Ser He Gly Phe Tyr Asn Thr Phe Gly Asn Ser Asp 225 230 235 240

Ala Phe Leu Gly Ser His Thr Met Pro Arg Gly Asn Asn Thr Ser Tyr

245 250 255

He Ser Asn Glu He Ser Val Thr Thr Arg His Ala Gly Met He Gly

260 265 270

Tyr Asp Phe Trp Asp Asn Thr Ala Tyr Asp Gly Leu Ala Asp Ala He 275 280 285 Thr Asn Ala Asn Thr Phe Thr Phe Tyr Thr Ser Val Gly Gly He His

290 295 300

Lys Arg Phe Ala Trp His Val Phe Gly Arg Val Ser His Ala Asn Lys 305 310 315 320

Asn Ala Leu Gly Gin Val Gly Arg Ala Asn Glu Tyr Ser Leu Gin Phe

325 330 335

Asn Ala Ser Tyr Ala Phe Thr Glu Ser Val Leu Leu Asn Phe Arg He

340 345 350

Thr Tyr Tyr Gly Ala Arg He Asn Lys Gly Tyr Gin Ala Gly Tyr Phe

355 360 365

Gly Ala Pro Lys Phe Asn Asn Pro Asp Gly Asp Phe Ser Ala Asn Tyr

370 375 380

Gin Asp Arg Ser Tyr Met Met Thr Asn Leu Thr Leu Lys Phe 385 390 395

(2) INFORMATION FOR SEQ ID NO: 1050:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 444 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...444

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1050:

Leu Ser Asn Ala Phe Ser Gin Tyr Leu Tyr Ser Leu Leu Gly Ala Tyr

1 5 10 15

Pro Thr Lys Leu Asn Gly Asn Asp Val Ser Ala Asn Ala Leu Leu Ser

20 25 30

Gly Ala Val Gly Ser Gly Thr Cys Ala Ala Ala Gly Thr Ala Gly Gly

35 40 45

Thr Thr Leu Asn Thr Gin Ser Ala Cys Thr Ala Ala Gly Tyr Tyr Trp

50 55 60

Leu Pro Ser Leu Thr Asp Arg He Leu Ser Thr He Gly Ser Gin Thr 65 70 75 80

Asn Tyr Gly Thr Asn Thr Asn Phe Pro Asn Met Gin Gin Gin Leu Thr

85 90 95

Tyr Leu Asn Ala Gly Asn Val Phe Phe Asn Ala Met Asn Lys Ala Leu

100 105 110

Glu Lys Asn Gly Thr Ala Thr Ala Asn Ser Thr Ser Ser Thr Ser Gly

115 120 125

Ala Thr Gly Ser Asp Gly Gin Thr Tyr Ser Gin Gin Ala He Gin Tyr

130 135 140

Leu Gin Gly Gin Gin Asn He Leu Asn Asn Ala Ala Asn Leu Leu Lys 145 150 155 160

Gin Asp Glu Leu Leu Leu Glu Ala Phe Asn Ser Ala Val Ala Ala Asn 165 170 175 He Gly Asn Lys Glu Phe Asn Ser Ala Ala Phe Thr Gly Leu Val Gin

180 185 190

Gly He He Asp Gin Ser Gin Leu Val Tyr Asn Glu Leu Thr Lys Asn

195 200 205

Thr He Ser Gly Ser Ala Val Asn Asn Ala Gly He Asn Ser Asn Gin

210 215 220

Ala Asn Ala Val Gin Gly Arg Ala Ser Gin Leu Pro Asn Ala Leu Tyr 225 230 235 240

Asn Val Gin Val Thr Leu Asp Lys He Asn Ala Leu Asn Asn Gin Val

245 250 255

Arg Ser Met Pro Tyr Leu Pro Gin Phe Arg Ala Gly Asn Ser Arg Ala

260 265 270

Thr Asn He Leu Asn Gly Phe Tyr Thr Lys Val Gly Tyr Lys Gin Phe

275 280 285

Phe Gly Lys Lys Arg Asn He Gly Leu Arg Tyr Tyr Gly Phe Phe Ser

290 295 300

Tyr Asn Gly Ala Ser Val Gly Phe Arg Ser Thr Gin Asn Asn Val Gly 305 310 315 320

Leu Tyr Thr Tyr Gly Val Gly Thr Asp Val Leu Tyr Asn He Phe Ser

325 330 335

Arg Ser Tyr Gin Asn Arg Ser Val Asp Met Gly Phe Phe Ser Gly He

340 345 350

Gin Leu Ala Gly Glu Thr Phe Gin Ser Thr Leu Arg Asp Asp Pro Asn

355 360 365

Val Lys Leu His Gly Lys He Asn Asn Thr His Phe Gin Phe Leu Phe

370 375 380

Asp Phe Gly Met Arg Met Asn Phe Gly Lys Leu Asp Gly Lys Ser Asn 385 390 395 400

Arg His Asn Gin His Thr Val Glu Phe Gly Val Val Val Pro Thr He

405 410 415

Tyr Asn Thr Tyr Tyr Lys Ser Ala Gly Thr Thr Val Lys Tyr Phe Arg

420 425 430

Pro Tyr Ser Val Tyr Trp Ser Tyr Gly Tyr Ser Phe 435 440

(2) INFORMATION FOR SEQ ID NO: 1051:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 133 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME / KEY : miscjeature

( B ) LOCATION 1 . . . 133

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 1051 :

Met Glu Leu He Lys Lys Leu Glu Lys Glu Ser Glu Val Leu Lys Lys 1 5 10 15 Asp Leu Gin Gin His Ser Asn Glu Leu Phe Lys Met Leu He He Asp

20 25 30

Asn Glu Asp Leu Phe Lys Glu Gin Phe Glu He Met Phe Lys Ala Trp

35 40 45

Val Glu He Val Lys Met Met Phe Glu Leu Thr Lys Lys Thr Lys Phe

50 55 60

Asp Gly Glu Met He Gly Tyr Thr Glu Glu Leu Leu Thr Phe Leu Val 65 70 75 80

Arg Asp Phe Phe Asn Gly He Phe Lys Ser Lys Val He Pro Lys Met

85 90 95

Pro He Phe Cys Gly Asp Val Lys Cys Glu Asp Phe Asn Ala Leu Arg

100 105 110

Ser Leu Val Tyr Leu Ser Val Leu Glu Leu Glu Glu Thr He Asn Pro

115 120 125

Asn Lys He Pro Phe 130

(2) INFORMATION FOR SEQ ID NO: 1052:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 696 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A ) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 696

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 1052 :

Met Lys He Lys Lys Ser Leu Phe Ala Leu Ser Phe Ser Leu Met Ala

1 5 10 15

Ser Leu Ser Arg Ala Glu Asp Asp Gly Phe Tyr Met Ser Val Gly Tyr

20 25 30

Gin He Gly Glu Ala Val Gin Lys Val Lys Asn Thr Gly Ala Leu Gin

35 40 45

Asn Leu Ala Asp Arg Tyr Asp Asn Leu Ser Asn Leu Leu Asn Gin Tyr

50 55 60

Asn Tyr Leu Asn Ser Leu Val Asn Leu Ala Ser Thr Pro Ser Ala He 65 70 75 80

Thr Gly Ala He Asp Asn Leu Ser Ser Ser Ala He Asn Leu Thr Ser

85 90 95

Ala Thr Thr Thr Ser Pro Ala Tyr Gin Ala Val Ala Leu Ala Leu Asn

100 105 110

Ala Ala Val Gly Met Trp Gin Val He Ala Phe Gly He Ser Cys Gly

115 120 125

Pro Gly Pro Asn Leu Gly Pro Glu His Leu Glu Asn Gly Gly Val Arg

130 135 140

Ser Phe Asp Asn Thr Pro Asn Tyr Ser Tyr Asn Thr Gly Ser Gly Thr 145 150 155 160 Thr Thr Thr Thr Cys Asn Gly Ala Ser Asn Val Gly Pro Asn Gly He

165 170 175

Leu Ser Ser Ser Glu Tyr Gin Val Leu Asn Thr Ala Tyr Gin Thr He

180 185 190

Gin Thr Ala Leu Asn Gin Asn Gin Gly Gly Gly Met Pro Ala Leu Asn

195 200 205

Ser Ser Lys Asn Met Val Val Asn He Asn Gin Thr Phe Thr Lys Asn

210 215 220

Pro Thr Thr Glu Tyr Thr Tyr Pro Asp Gly Asn Gly Asn Tyr Tyr Ser 225 230 235 240

Gly Gly Ser Ser He Pro He Gin Leu Lys He Ser Ser Val Asn Asp

245 250 255

Ala Glu Asn Leu Leu Gin Gin Ala Ala Thr He He Asn Val Leu Thr

260 265 270

Thr Gin Asn Pro His Val Asn Gly Gly Gly Gly Ala Trp Gly Phe Gly

275 280 285

Gly Lys Thr Gly Asn Val Met Asp He Phe Gly Asp Ser Phe Asn Ala

290 295 300

He Asn Glu Met He Lys Asn Ala Gin Ala Val Leu Glu Lys Thr Gin 305 310 315 320

Gin Leu Asn Ala Asn Glu Asn Thr Gin He Thr Gin Pro Asp Asn Phe

325 330 335

Asn Pro Tyr Thr Ser Lys Asp Thr Gin Phe Ala Gin Glu Met Leu Asn

340 345 350

Arg Ala Asn Ala Gin Ala Glu He Leu Ser Leu Ala Gin Gin Val Ala

355 360 365

Asp Asn Phe His Ser He Gin Gly Pro He Gin Gin Asp Leu Glu Glu

370 375 380

Cys Thr Ala Gly Ser Ala Gly Val He Asn Asp Asn Thr Tyr Gly Ser 385 390 395 400

Gly Cys Ala Phe Val Lys Glu Thr Leu Asn Ser Leu Glu Gin His Thr

405 410 415

Ala Tyr Tyr Gly Asn Gin Val Asn Gin Asp Arg Ala Leu Ser Gin Thr

420 425 430

He Leu Asn Phe Lys Glu Ala Leu Ser Thr Leu Gly Asn Asp Ser Lys

435 440 445

Ala He Asn Ser Gly He Ser Asn Leu Pro Asn Ala Lys Ser Leu Gin

450 455 460

Asn Met Thr His Ala Thr Gin Asn Pro Asn Ser Pro Glu Gly Leu Leu 465 470 475 480

Thr Tyr Ser Leu Asp Thr Ser Lys Tyr Asn Gin Leu Gin Thr Val Ala

485 490 495

Gin Glu Leu Gly Lys Asn Pro Phe Arg Arg He Gly Val He Asn Tyr

500 505 510

Gin Asn Asn Asn Gly Ala Met Asn Gly He Gly Val Gin Ala Gly Tyr

515 520 525

Lys Gin Phe Phe Gly Lys Lys Arg Asn Trp Gly Leu Arg Tyr Tyr Gly

530 535 540

Phe Phe Asp Tyr Asn His Ala Tyr He Lys Ser Asn Phe Phe Asn Ser 545 550 555 560

Ala Ser Asp Val Trp Thr Tyr Gly Val Gly Met Asp Ala Leu Tyr Asn

565 570 575

Phe He Asn Asp Lys Asn Thr Asn Phe Leu Gly Lys Asn Asn Lys Leu

580 585 590

Ser Val Gly Leu Phe Gly Gly Phe Ala Leu Ala Gly Thr Ser Trp Leu

595 600 605

Asn Ser Gin Gin Val Asn Leu Thr Met Met Asn Gly He Tyr Asn Ala 610 615 620

Asn Val Ser Ala Ser Asn Phe Gin Phe Leu Phe Asp Leu Gly Leu Arg 625 630 635 640

Met Asn Leu Ala Arg Pro Lys Lys Lys Asp Ser Asp His Ala Ala Gin

645 650 655

His Gly Met Glu Leu Gly Val Lys He Pro Thr He Asn Thr Asp Tyr

660 665 670

Tyr Ser Phe Met Gly Ala Glu Leu Lys Tyr Arg Arg Leu Tyr Ser Val

675 680 685

Tyr Leu Asn Tyr Val Phe Ala Tyr 690 695

(2) INFORMATION FOR SEQ ID NO: 1053:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 371 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 371

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1053:

Met Gin Phe Gin Lys Thr Leu Ser Ser Leu Ser Leu Phe Leu Ser Leu

1 5 10 15

Ser Leu Phe Leu Ser Phe Ser He Ala Glu Glu Asn Gly Ala Tyr Ala

20 25 30

Ser Val Gly Phe Glu Tyr Ser He Ser His Ala Val Glu His Asn Asn

35 40 45

Pro Phe Leu Asn Gin Glu Arg He Gin Thr He Ser Asn Ala Gin Asn

50 55 60

Lys He Tyr Lys Leu Asn Gin Val Lys Asn Glu He Thr Asn Met Pro 65 70 75 80

Asn Thr Phe Asn Tyr He Asn Asn Ala Leu Lys Asn Asn Ala Lys Leu

85 90 95

Thr Pro Thr Glu Lys Gin Ala Glu Thr Tyr Tyr Leu Gin Ser Thr Leu

100 105 110

Gin Asn He Glu Lys He Val Met Leu Ser Gly Gly Val Ala Ser Asn

115 120 125

Pro Lys Leu Ala Gin Ala Leu Glu Lys Met Gin Glu Pro He Thr Asn

130 135 140

Pro Leu Glu Leu Val Glu Asn Leu Lys Asn Leu Glu Leu Gin Phe Ser 145 150 155 160

Gin Ser Gin Asn Ser Met Leu Ser Ser Leu Ser Ser Gin He Ala Gin

165 170 175

He Ser Asn Ser Leu Asn Ala Leu Asp Pro Ser Ser Tyr Ser Lys Asn

180 185 190

Val Ser Ser Met Tyr Gly Val Gly Leu Ser Val Gly Tyr Lys His Phe 195 200 205

Phe Thr Lys Lys Lys Asn Gin Gly Phe Arg Tyr Tyr Leu Phe Tyr Asp

210 215 220

Tyr Gly Tyr Thr Asn Phe Gly Phe Val Gly Asn Gly Phe Asp Gly Leu 225 230 235 240

Gly Lys Met Asn Asn His Leu Tyr Gly Leu Gly He Asp Tyr Leu Phe

245 250 255

Asn Phe He Asp Asn Ala Gin Lys His Ser Ser Val Gly Phe Tyr Val

260 265 270

Gly Phe Ala Leu Ala Gly Ser Ser Trp Val Gly Ser Gly Leu Gly Met

275 280 285

Trp Val Ser Gin Met Asp Phe He Asn Asn Tyr Leu Thr Asp Tyr Arg

290 295 300

Ala Lys Met His Thr Ser Phe Phe Gin He Pro Leu Asn Phe Gly Val 305 310 315 320

Arg Val Asn Val Asp Arg His Asn Gly Phe Glu Met Gly Leu Lys He

325 330 335

Pro Leu Ala Val Asn Ser Phe Tyr Glu Thr His Gly Lys Gly Leu Asn

340 345 350

Ala Ser Leu Phe Phe Lys Arg Leu Val Met Phe Asn Val Ser Tyr Val

355 360 365

Tyr Ser Phe 370

(2) INFORMATION FOR SEQ ID NO: 1054:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 484 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...484

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 1054 :

Met Ala Lys He Thr Thr Val He Asp He Gly Ser Asn Ser Val Arg

1 5 10 15

Leu Ala Val Phe Lys Lys Thr Ser Gin Phe Gly Phe Tyr Leu Leu Phe

20 25 30

Glu Thr Lys Ser Lys Val Arg He Ser Glu Gly Cys Tyr Ala Phe Lys

35 40 45

Gly Val Leu Gin Glu He Pro Met Gin Arg Ala Val Lys Ala Leu Ser

50 55 60

Glu Phe Lys Glu He Ala Leu Lys Tyr Lys Ser Lys Lys He Leu Cys 65 70 75 80

Val Ala Thr Ser Ala Val Arg Asp Ala Pro Asn Arg Leu Glu Phe Val

85 90 95

Ala Arg Val Lys Lys Ala Cys Gly Leu Gin He Lys He He Asp Gly 100 105 110

Gin Lys Glu Ala Leu Tyr Gly Gly He Ala Cys Ala Asn Leu Leu His

115 120 125

Lys Asn Ser Gly He Thr He Asp He Gly Gly Gly Ser Thr Glu Cys

130 135 140

Ala Leu He Glu Lys Gly Lys He Lys Asp Leu He Ser Leu Asp Val 145 150 155 160

Gly Thr He Arg He Lys Glu Met Phe Leu Asp Lys Asp Leu Asp Val

165 170 175

Lys Leu Ala Lys Ala Phe He Gin Lys Glu Val Ser Lys Leu Pro Phe

180 185 190

Lys His Lys Asn Ala Phe Gly Val Gly Gly Thr He Arg Ala Leu Ser

195 200 205

Lys Val Leu Met Lys Arg Phe Asp Tyr Pro He Asp Ser Leu His Gly

210 215 220

Tyr Glu He Asp Ala His Lys Asn Leu Ala Phe He Glu Lys He Val 225 230 235 240

Met Leu Lys Glu Asp Lys Leu Arg Leu Leu Gly Val Asn Glu Glu Arg

245 250 255

Leu Asp Ser He Arg Ser Gly Ala Leu He Leu Ser Val Val Leu Glu

260 265 270

His Leu Lys Thr Ser Leu Met He Thr Ser Gly Val Gly Val Arg Glu

275 280 285

Gly Val Phe Leu Ser Asp Leu Leu Arg His His Tyr His Lys Phe Pro

290 295 300

Pro Asn He Asn Pro Ser Leu He Ser Leu Lys Asp Arg Phe Leu Pro 305 310 315 320

His Glu Lys His Ser Gin Lys Val Lys Lys Glu Cys Val Lys Leu Phe

325 330 335

Glu Val Leu Ser Pro Leu His Lys He Asp Glu Lys Tyr Leu Phe His

340 345 350

Leu Lys He Ala Gly Glu Leu Ala Ser Met Gly Lys He Leu Ser Val

355 360 365

Tyr Leu Ala His Lys His Ser Ala Tyr Phe He Leu Asn Ala Leu Ser

370 375 380

Tyr Gly Phe Ser His Gin Asp Arg Ala He He Cys Leu Leu Ala Gin 385 , 390 395 400

Phe Ser His Lys Lys He Pro Lys Asp Asn Ala He Ala His Met Ser

405 410 415

Ala Met Met Pro Ser Leu Leu Thr Leu Gin Trp Leu Ser Phe He Leu

420 425 430

Ser Leu Ala Glu Asn Leu Cys Leu Thr Asp Ser His His Leu Lys Tyr

435 440 445

Thr Leu Glu Lys Asn Lys Leu Val He His Ser Asn Asp Ala Leu Tyr

450 455 460

Leu Ala Lys Glu Met Leu Pro Lys Leu He Lys Pro He Pro Leu Thr 465 470 475 480

He Glu Phe Ala

(2) INFORMATION FOR SEQ ID NO: 1055:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 253 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...253

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1055:

Lys Gin Val Lys Ser Arg Met Lys Glu Lys Pro Phe Asn Ser Glu Gin

1 5 10 15

Met Ala Phe Leu Glu Glu Leu Leu Ser His Gin Glu Lys His Leu Glu

20 25 30

Ser Lys Leu Ser Gly Phe Ser Val Asn Asp Leu Asp Met Gin Ser Val

35 40 45

Phe Arg Leu Glu Arg Asn Arg Leu Lys He Ala Tyr Arg Leu Leu Gly

50 55 60

Leu Met Ser Phe He Ala Leu Val Leu Ala He Val Leu He Ser He 65 70 75 80

Leu Pro Leu Gin Lys Thr Glu His His Phe Val Asp Phe Leu Asn Gin

85 90 95

Asp Lys His Tyr Ala He He Gin Arg Ala Asp Lys Ser He Ser Ser

100 105 110

Asn Glu Ala Leu Ala Arg Ser Leu He Gly Ala Tyr Val Leu Asn Arg

115 120 125

Glu Ser He Asn Arg He Asp Asp Lys Ser Arg Tyr Glu Leu Val Arg

130 135 140

Leu Gin Ser Ser Ser Lys Val Trp Gin Arg Phe Glu Asp Leu He Lys 145 150 155 160

Ala Gin Asn Ser He Tyr Val Gin Ser His Leu Glu Arg Glu Val His

165 170 175

He Val Asn He Ala He Tyr Gin Gin Asp Asn Asn Pro He Ala Ser

180 185 190

Val Ser He Ala Ala Lys Leu Leu Asn Glu Asn Lys Leu Val Tyr Glu

195 200 205

Lys Arg Tyr Lys He Val Leu Ser Tyr Leu Phe Asp Thr Pro Asp Phe

210 215 220

Asp Tyr Ala Ser Met Pro Lys Asn Pro Thr Gly Phe Lys He Thr Arg 225 230 235 240

Tyr Ser He Thr Glu He Ala Pro Thr Asn Arg Asn Asp 245 250

(2) INFORMATION FOR SEQ ID NO: 1056:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 479 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME / KEY : mi scjeature

( B ) LOCATION 1 . . . 479

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1056:

Met Lys Lys Ser Leu Cys Leu Ser Phe Phe Leu Thr Phe Ser Asn Pro

1 5 10 15

Leu Gin Ala Leu Val He Glu Leu Leu Glu Glu He Lys Thr Ser Pro

20 25 30

His Lys Gly Thr Phe Lys Ala Lys Val Leu Asp Ser Lys Glu Pro Arg

35 40 45

Gin Val Leu Gly Val Tyr Asn He Ser Pro His Lys Lys Leu Thr Leu

50 55 60

Thr He Thr His He Ser Thr Ala He Val Tyr Gin Pro Leu Asp Glu 65 70 75 80

Lys Leu Ser Leu Glu Thr Thr Leu Ser Pro Asn Arg Pro Thr He Pro

85 90 95

Arg Asn Thr Gin He Val Phe Ser Ser Lys Glu Leu Lys Glu Pro His

100 105 110

Ser Asn Pro He Pro Ser Leu Asn Ala Pro Met Gin Lys Pro Gin Asn

115 120 125

Lys Pro Ser Ser Ser Gin Gin Ser Pro Gin Asn Phe Ser Tyr Pro Glu

130 135 140

Ser Lys Leu Gly Ser Lys Asn Ser Lys Asn Ser Leu Leu Gin Pro Leu 145 150 155 160

Val Thr Pro Ser Lys Val Ser Pro Thr Asn Glu Val Lys Thr Pro Thr

165 170 175

Asn Asp Ala Asn Pro Pro Leu Lys His Ser Ser Gin Asp Gin Glu Asn

180 185 190

Asn Leu Phe Val Ala Pro Pro Thr Glu Lys Thr Leu Pro Asn Asn Thr

195 200 205

Ser Ser Ala Asp Ala Ser Glu Asn Asn Glu Ser Asn Glu Asn Arg Asp

210 215 220

Asn Val Glu Lys Gin Ala He Arg Asp Pro Asn He Lys Glu Phe Ala 225 230 235 240

Cys Gly Lys Trp Val Tyr Asp Asp Glu Asn Leu Gin Ala Tyr Arg Pro

245 250 255

Ser He Leu Lys Arg Val Asp Lys Asp Lys Glu He Thr Thr Asp He

260 265 270

Thr Pro Cys Asp Tyr Ser Thr Ala Glu Asn Lys Ser Gly Lys He He

275 280 285

Thr Pro Tyr Thr Lys He Ser Val His Lys Thr Glu Pro Leu Glu Asp

290 295 300

Pro Gin Thr Phe Glu Ala Lys Asn Asn Phe Ala He Leu Gin Ala Arg 305 310 315 320

Ser Ser Thr Glu Lys Cys Lys Arg Ala Arg Ala Arg Lys Asp Gly Thr

325 330 335

Thr Arg Gin Cys Tyr Leu He Glu Glu Pro Leu Lys Gin Ala Trp Glu

340 345 350

Ser Glu Tyr Glu He Thr Thr Gin Leu Val Lys Ala He Tyr Glu Arg

355 360 365

Pro Lys Gin Asp Asp Gin Val Glu Pro Thr Phe Tyr Glu Thr Ser Glu 370 375 380 Leu Ala Tyr Ser Ser Thr Arg Lys Ser Glu He Thr Arg Asn Glu Leu 385 390 395 400

Asn Leu Asn Glu Lys Phe Met Glu Phe Val Glu Val Tyr Glu Gly His

405 410 415

Tyr Leu Asn Asp He He Lys Glu Ser Ser Glu Tyr Lys Glu Trp Val

420 425 430

Lys Asn His Val Arg Phe Lys Glu Gly Val Cys Met Ala Leu Glu He

435 440 445

Glu Glu Gin Pro Arg Ala Lys Ser Thr Pro Leu Ser He Glu Asn Ser

450 455 460

Arg Val Val Cys Val Lys Lys Gly Asn Tyr Leu Phe Asn Glu Val 465 470 475

(2) INFORMATION FOR SEQ ID NO: 1057:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 567 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME / KEY : miscjeature

( B ) LOCATION 1 . . . 567

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 1057 :

Met He Phe Gly Asp Phe Lys Tyr Gin Lys Ser Val Lys Lys Leu Thr

1 5 10 15

Ala Thr Asn Leu Asn Glu Leu Lys Asn Ala Leu Asp Phe He Ser Gin

20 25 30

Asn Arg Gly Lys Gly Tyr Phe Val Gly Tyr Leu Leu Tyr Glu Ala Arg

35 40 45

Leu Ala Phe Leu Asp Glu Asn Phe Gin Ser Gin Thr Pro Phe Leu Tyr

50 55 60

Phe Glu Gin Phe Leu Glu Arg Lys Lys Tyr Pro Leu Glu Pro Leu Lys 65 70 75 80

Glu His Ala Phe Tyr Pro Lys He His Ser Ser Leu Asp Gin Lys Thr

85 90^ 95

Tyr Phe Lys Gin Phe Lys Ala Val Lys Glu His Leu Lys Asn Gly Asp

100 105 110

Thr Tyr Gin Val Asn Leu Thr Met Asp Leu Leu Leu Asn Thr Lys Ala

115 120 125

Lys Pro Lys Arg Val Phe Lys Glu Val He His Asn Gin Asn Thr Pro

130 135 140

Phe Lys Ala Phe He Glu Asn Glu Phe Gly Ser Val Leu Ser Phe Ser 145 150 155 160

Pro Glu Leu Phe Phe Glu Leu Glu Phe Leu Asp Thr Ala He Lys He

165 170 175

He Thr Lys Pro Met Lys Gly Thr He Ala Arg Ser Asn Asn Pro Leu 180 185 190 He Asp Glu Lys Asn Arg Leu Phe Leu Gin Asn Asp Asp Lys Asn Arg

195 200 205

Ser Glu Asn Val Met He Val Asp Leu Leu Arg Asn Asp Leu Ser Arg

210 215 220

Leu Ala Leu Lys Asn Ser Val Lys Val Asn Gin Leu Phe Glu He He 225 230 235 240

Ser Leu Pro Ser Val Tyr Gin Met He Ser Glu He Glu Ala Gin Leu

245 250 255

Pro Leu Lys Thr Ser Leu Phe Glu He Phe Lys Ala Leu Phe Pro Cys

260 265 270

Gly Ser Val Thr Gly Cys Pro Lys He Lys Thr Met Gin He He Glu

275 280 285

Ser Leu Glu Lys Arg Pro Arg Gly Val Tyr Cys Gly Ala He Gly Met

290 295 300

Val Gly Gly Lys Lys Ala Leu Phe Ser Val Pro He Arg Thr Leu Glu 305 310 315 320

Lys Arg Ala His Glu Asp Phe Leu His Leu Gly Val Gly Ser Gly Val

325 330 335

Thr Tyr Lys Ser Lys Ala Ser Lys Glu Tyr Glu Glu Ser Phe Leu Lys

340 345 350

Ser Phe Phe Val Met Pro Lys He Glu Phe Glu He Val Glu Thr Met

355 360 365

Arg Val He Lys Arg Asp Gin Lys Leu Glu He Asn Asn Lys Asn Ala

370 375 380

His Lys Glu Arg Leu Met His Ser Ala Gin Tyr Phe Asn Phe Lys Tyr 385 390 395 400

Asp Glu Asn Leu Leu Asp Phe Glu Leu Glu Lys Glu Gly Val Leu Arg

405 410 . 415

Val Leu Leu Asn Lys Arg Gly Lys Leu He Lys Glu Tyr Arg Thr Leu

420 425 430

Glu Pro Leu Lys Ser Leu Glu He Arg Leu Ser Glu Ala Pro He Asp

435 440 445

Lys His Asp Asp Phe Leu Tyr His Lys Thr Ala Tyr Ala Pro Phe Tyr

450 455 460

Gin Asn Ala Arg Ala Leu He Lys Lys Gly Val He Phe Asp Glu He 465 470 475 480

Phe Tyr Asn Gin Asp Leu Glu Leu Thr Glu Gly Ala Arg Ser Asn Leu

485 490 495

He Leu Glu He His Asn Arg Leu Leu Thr Pro Tyr Phe Ser Val Gly

500 505 510

Ala Leu Thr Gly Thr Gly Val Val Gly Leu Leu Lys Lys Gly Leu Val

515 520 525

Glu His Ala Pro Leu Lys Leu Gin Asp Leu Gin Arg Ala Ala Lys He

530 535 540

Tyr Cys He Asn Ala Leu Tyr Gly Leu Val Glu Val Gly He He Gly 545 550 555 560

Tyr Pro Met Glu Gin Lys Ser 565

(2) INFORMATION FOR SEQ ID NO: 1058:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 374 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein (m) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE.

(A) NAME/KEY: miscjeature

(B) LOCATION 1...374

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 1058 :

Met Lys He Ser Val Ser Lys Asn Asp Leu Glu Asn Thr Leu Arg Tyr

1 5 10 15

Leu Gin Ala Phe Leu Asp Lys Lys Asp Ala Ser Ser He Ala Ser His

20 25 30

He His Leu Glu Val He Lys Glu Lys Leu Phe Leu Lys Ala Ser Asp

35 40 45

Ser Asp He Gly Leu Lys Ser Tyr He Ser Thr Gin Ser Thr Asp Lys

50 55 60

Glu Gly Val Gly Thr He Asn Gly Lys Lys Phe Leu Asp He He Ser 65 70 75 80

Cys Leu Lys Asp Ser Asn He Val Leu Glu Thr Lys Asp Asp Ser Leu

85 90 95

Val He Lys Gin Asn Lys Ser Ser Phe Lys Leu Pro Met Phe Asp Ala

100 105 110

Asp Glu Phe Pro Glu Phe Pro Val He Asp Pro Lys Val Ser Leu Glu

115 120 125

He Asn Ala Pro Phe Leu Val Asp Ala Phe Lys Lys He Ala Pro Val

130 135 140

He Glu Gin Thr Ser His Lys Arg Glu Leu Ala Gly Val Leu Met Gin 145 150 155 160

Phe Asn Gin Lys His Gin Thr Leu Ser Val Val Gly Thr Asp Thr Lys

165 170 175

Arg Leu Ser Tyr Thr Gin Leu Glu Lys He Ser He His Ser Thr Glu

180 185 190

Glu Asp He Ser Cys He Leu Pro Lys Arg Ala Leu Leu Glu He Leu

195 200 205

Lys Leu Phe Tyr Glu Asn Phe Ser Phe Lys Ser Asp Gly Met Leu Ala

210 215 220

Val Val Glu Asn Glu Thr His Ala Phe Phe Thr Lys Leu He Asp Gly 225 230 235 240

Asn Tyr Pro Asp Tyr Gin Lys He Leu Pro Lys Glu Tyr Thr Ser Ser

245 250 255

Phe Thr Leu Gly Lys Glu Glu Phe Lys Glu Gly He Lys Leu Cys Ser

260 265 270

Ser Leu Ser Ser Thr He Lys Leu Thr Leu Glu Lys Asn Asn Ala Leu

275 280 285

Phe Glu Ser Leu Asp Ser Glu His Ser Glu Thr Ala Lys Thr Ser Val

290 295 300

Glu He Glu Lys Gly Leu Asp He Glu Lys Ala Phe His Leu Gly Val 305 310 315 320

Asn Ala Lys Phe Phe Leu Glu Ala Leu Asn Ala Leu Gly Thr Thr Gin

325 330 335

Phe Val Leu Lys Cys Asn Glu Pro Ser Ser Pro Phe Leu He Gin Glu

340 345 350

Pro Leu Asp Glu Lys Gin Ser His Leu Asn Ala Lys He Ser Thr Leu 355 360 365

Met Met Pro He Thr Leu 370

(2) INFORMATION FOR SEQ ID NO.1059

(l) SEQUENCE CHARACTERISTICS.

(A) LENGTH: 368 ammo acids

(D) TOPOLOGY: linear

(n) MOLECULE TYPE: protein

(m) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...368

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 1059 :

Met Val Val Leu Gly Ser Thr Gly Ser He Gly Lys Asn Ala Leu Lys

1 5 10 15

He Ala Lys Lys Phe Gly Val Lys He Glu Ala Leu Ser Cys Gly Lys

20 25 30

Asn He Ala Leu He Asn Glu Gin He Lys Val Phe Lys Pro Lys Lys

35 40 45

Val Ala He Leu Asp Pro Asn Asp Leu Asn Asn Leu Glu Pro Leu Gly

50 55 60

Ala Glu Val Phe Val Gly Leu Asp Gly He Asp Ala Met He Glu Glu 65 70 75 80

Cys Val Ser Asn Leu Val He Asn Ala He Val Gly Val Ala Gly Leu

85 90 95

Lys Ala Ser Phe Lys Ser Leu Gin Arg Asn Lys Lys Leu Ala Leu Ala

100 105 110

Asn Lys Glu Ser Leu Val Ser Ala Gly His Leu Leu Asp He Ser Gin

115 120 125

He Thr Pro Val Asp Ser Glu His Phe Gly Leu Trp Ala Leu Leu Gin

130 135 140

Asn Lys Thr Leu Lys Pro Lys Ser Leu He He Ser Ala Ser Gly Gly 145 150 155 160

Ala Phe Arg Asp Thr Pro Leu Asp Leu He Ala He Gin Asn Ala Gin

165 170 175

Asn Ala Leu Lys His Pro Asn Trp Ser Met Gly Asp Lys He Thr He

180 185 190

Asp Ser Ala Ser Met Val Asn Lys Leu Phe Glu He Leu Glu Thr Tyr

195 200 205

Trp Leu Phe Gly Ala Ser Leu Lys He Asp Ala Leu He Glu Arg Ser

210 215 220

Ser He Val His Ala Leu Val Glu Phe Glu Asp Asn Ser Val He Ala 225 230 235 240

His Leu Ala Ser Ala Asp Met Gin Leu Pro He Ser Tyr Ala He Asn

245 250 255

Pro Lys Leu Ala Ser Leu Ser Ala Ser He Lys Pro Leu Asp Leu Tyr 260 265 270

Ala Leu Ser Ala He Lys Phe Glu Pro He Ser Val Glu Arg Tyr Thr

275 280 285

Leu Trp Arg Tyr Lys Asp Leu Leu Leu Glu Asn Pro Lys Leu Gly Val

290 295 300

Val Leu Asn Ala Ser Asn Glu Val Ala Met Lys Lys Phe Leu Asn Gin 305 310 315 320

Glu He Ala Phe Gly Gly Phe He Gin He He Ser Gin Ala Leu Glu

325 330 335

Leu Tyr Ala Lys Lys Ser Phe Lys Leu Ser Ser Leu Asp Glu Val Leu

340 345 350

Ala Leu Asp Lys Glu Val Arg Glu Arg Phe Gly Ser Val Ala Arg Val 355 360 365

(2) INFORMATION FOR SEQ ID NO: 1060:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 417 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...417

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 1060 :

Met Lys Tyr Leu Trp Leu Phe Leu He Tyr Ala He Gly Leu Phe Ala

1 5 10 15

Thr Asp Lys Thr Leu Asp He He Lys Thr He Gin Lys Leu Pro Lys

20 25 30

He Glu Val Arg Tyr Ser He Asp Asn Asp Ala Asn Tyr Ala Leu Lys

35 40 45

Leu His Glu Val Leu Ala Asn Asp Leu Lys Thr Ser Gin His Phe Asp

50 55 60

Val Ser Gin Asn Lys Glu Gin Gly Ala He Asn Tyr Ala Glu Leu Lys 65 70 75 80

Asp Lys Lys Val His Leu Val Ala Leu Val Ser Val Ala Val Glu Asn

85 90 95

Gly Asn Lys He Ser Arg Leu Lys Leu Tyr Asp Val Asp Thr Gly Thr

100 105 110

Leu Lys Lys Thr Phe Asp Tyr Pro He Val Ser Leu Asp Leu Tyr Pro

115 120 125

Phe Ala Ala His Asn Met Ala He Val Val Asn Asp Tyr Leu Lys Ala

130 135 140

Pro Ser He Ala Trp Met Lys Arg Leu He Val Phe Ser Lys Tyr He 145 150 155 160

Gly Pro Gly He Thr Asn He Ala Leu Ala Asp Tyr Thr Met Arg Tyr

165 170 175

Gin Lys Glu He He Lys Asn Asn Arg Leu Asn He Phe Pro Lys Trp 180 185 190

Ala Asn Ala Glu Gin Thr Glu Phe Tyr Tyr Thr Gin Tyr Gly Glu Lys

195 200 205

Thr Pro Met He Leu Lys Tyr Asn He Gin Lys Ala Thr His Glu Asn

210 215 220

He Ala Ser Ser Gin Gly Met Ala Val Val Ser Ser Val Ser Ser Asp 225 230 235 240

Gly Ser Lys He Leu Met Ser Leu Ala Pro Asp Gly Gin Pro Asp Val

245 250 255

Tyr Leu Tyr Asp Thr His Lys Lys Thr Lys Thr Lys He Thr Arg Tyr

260 265 270

Pro Gly He Asp Val Ser Gly Val Phe Leu Glu Asp Asp Lys Ser Met

275 280 285

Ala Phe Val Ser Asp Arg Ser Gly Tyr Pro Asn He Tyr Met Lys Lys

290 295 300

Leu Gly Leu Lys Glu Ser Ala Glu Gin Leu Leu Tyr Glu Gly Arg Ser 305 310 315 320

Asn Glu Ser He Asp Ala Tyr Lys Asp Ser He Val Tyr Val Ser Arg

325 330 335

Glu Asn Leu Asn Glu Phe Gly Lys Thr Val Phe Asn Leu Asn Leu He

340 345 350

Ala Leu Asn Ser Lys Tyr He Arg Arg Leu Thr Val Asn Gly Ser Asn

355 360 365

Gin Met Pro Arg Phe Ser Met Asp Gly Arg Asn He Met Tyr He Lys

370 375 380

Lys Thr Ser Gin Glu Tyr Ala Met Gly Leu He Leu Leu Asp Tyr Asn 385 390 395 400

Gin Ser Phe Leu Phe Pro Leu Lys Asn Val Lys He Gin Ala Phe Asp

405 410 415

Trp

(2) INFORMATION FOR SEQ ID NO: 1061:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 219 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A ) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 219

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 1061 :

Val Asn Lys Lys Hi s Arg Leu Ala Phe Leu Gly Leu He Val Gly Val

1 5 10 15

Leu Phe Phe Phe Ser Ala Cys Gin His Arg Leu His Met Gly Tyr Tyr

20 25 30

Ser Glu Val Thr Gly Asp Tyr Leu Phe Asn Tyr Asn Ser Thr He Val 35 40 45

Val Ala Tyr Asp Arg Ser Asp Ala Met Thr Ser Tyr Tyr He Asn Val

50 55 60

He Val Tyr Glu Leu Gin Lys Leu Gly Phe Tyr Asn Val Phe Thr Gin 65 70 75 80

Ala Glu Phe Pro Leu Asp Lys Ala Lys Asn Val He Tyr Val Arg He

85 90 95

Val Arg Asn He Ser Ala Val Pro Phe Tyr Gin Tyr Asn Tyr Gin Leu

100 105 110

He Asp Gin Val Asn Lys Pro Cys Tyr Phe Leu Gly Gly Gin Phe Tyr

115 120 125

Cys Ser Gin Thr Pro Thr Asp Tyr Tyr Ala He Asn Gly Phe Ser Glu

130 135 140

Gin He Leu Met Ser Ala Asn Ser His Phe He Leu Asp Trp Tyr Asp 145 150 155 160

Val Val Leu Gin Lys Arg Val Leu Tyr Val Asp Gly Ser Val Ser Gly

165 170 175

Arg Thr Cys Gly Tyr Gin Met Leu Tyr Arg Asp Leu He Lys Ser Thr

180 185 190

He Lys Arg He Asp Phe Asn Arg Pro Glu Arg Tyr Tyr Tyr Asn Leu

195 200 205

Arg Leu Pro Leu Tyr Gin Pro Cys Tyr Arg Gin 210 215

(2) INFORMATION FOR SEQ ID NO: 1062:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 416 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...416

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1062:

Met Gin Tyr Lys Lys Asn Lys Lys Arg Tyr Tyr His Leu Ala Leu Gly

1 5 10 15

He Leu Phe Cys Asn Gly Leu Ser Leu Lys Ala Leu Glu He Ala Val

20 25 30

Lys Pro Phe Gly Tyr Leu Gly Leu Leu Tyr Asn Gin Gly Thr Gin Lys

35 40 45

Asn Pro His Ser Tyr Val Gly Ala Leu Ala Arg Leu Gly Val Asp Phe

50 55 60

Ser Tyr Ser Asn Gly Trp Ser Phe Gly He Gly Ala He Gly Ala Trp 65 70 75 80

Asn He Tyr Asn Lys Gin Arg Leu Ala Asn Leu Tyr He Ser Leu Gly

85 90 95

Asn Phe Phe Gly Asn Pro Asn Asn Val Lys Pro Tyr Leu Ser Ala Gly 100 105 110

Asp Val Ser Asp Ala Tyr Leu Gin Tyr Ala Asn Gin Arg Phe Lys He

115 120 125

Ala Leu Gly Arg Phe Asn Thr Asp Phe Val Asp Phe Asp Trp He Gly

130 135 140

Gly Asn He Gin Gly Val Ser Val Ala Phe Lys Gin Asn Ser Met Arg 145 150 155 160

Tyr Phe Gly He Phe Met Asp Ser Met Leu Tyr Asn Gly His Gin He

165 170 175

Asn Lys Glu Gin Gly Asn Arg He Ala Thr Ser Leu Asn Ala Leu Ala

180 185 190

Ser Tyr Asp Pro Val Ser Lys Arg Leu Tyr Val Gly Gly Glu Val Phe

195 200 205

Val Leu Gly Ala Glu Tyr Lys Asn Lys Asn Leu He Phe Val Pro Phe

210 215 220

He Leu Thr Asp Thr Arg Leu Pro Leu Pro Thr Gin Asn Val Leu Val 225 230 235 240

Gin Val Gly Gly Lys Leu Glu Tyr Asp Ala Ser Leu Ala Lys Gly Phe

245 250 255

Thr Ser Arg Thr Leu Val His Gly Met Tyr Gin Tyr Gly Asn Thr Asp

260 265 270

He Thr Thr Ser Ala Lys Asn Ala Gly Leu Phe Leu He Asp Gin Thr

275 280 285

Phe Lys Tyr Lys He Phe Asn Phe Gly Thr Gly Phe Tyr He Val Pro

290 295 300

Ala Arg Asn Asn Lys Gly Tyr Leu Trp Thr Phe Asn Asp Arg Thr Lys 305 310 315 320

Phe Tyr Gly Arg Gly He Asn Ala Pro Gly Val Pro Ala He Tyr Phe

325 330 335

Ala Asn Ser Ser He Ser Gly Tyr Val Phe Leu Gly Leu Lys Thr Lys

340 345 350

Arg Val Arg Leu Asp Ala Met Val Ala Phe Gly Asp Tyr Gin Glu Tyr

355 360 365

Ser Leu Met Ser Ser Phe Arg Val Trp Thr Tyr Arg Asp Leu Ser Phe

370 375 380

Asp Met Gly Gly Gly Tyr Val Tyr Ala Tyr Asn Ser Lys Ala Thr Arg 385 390 395 400

Lys Ser Leu Gly Asp Ser Ser Phe Val Phe Phe Gly Lys Phe Leu Phe 405 410 415

(2) INFORMATION FOR SEQ ID NO: 1063:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 668 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 668 (xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 1063 :

Met Val Lys Asn Thr Lys Gly He Gin Gin Leu Ser Glu Asn Tyr Glu

1 5 10 15

Lys Leu Asn Asn Leu Leu Asn Asn Tyr Asn Thr Leu Asn Thr Leu Val

20 25 30

Lys Leu Ser Ser Asp Pro Ser Ala Val Asn Asp Ala Arg Asp Asn Leu

35 40 45

Gly Ser Ser Thr Arg Asn Leu Leu Asp Val Lys Ala Asn Ser Pro Ala

50 55 60

Tyr Gin Ala Val Leu Leu Ala Leu Asn Ala Ala Val Gly Leu Trp Gin 65 70 75 80

Val Thr Ser Tyr Ala Phe Thr Ala Cys Gly Pro Gly Ser Asn Glu Asn

85 90 95

Ala Asn Gly Gly He Gin Thr Phe Asn Asn Val Pro Gly Gin Asn Thr

100 105 110

Thr Thr He Thr Cys Asn Ser Tyr Tyr Glu Pro Gly His Gly Gly Pro

115 120 125

He Ser Thr Lys Asn Tyr Ala He He Asn Lys Ala Tyr Gin He He

130 135 140

Gin Lys Ala Leu Thr Ala Asn Gly Glu Gly He Pro Val Leu Ser Asn 145 150 155 160

Thr Thr Thr Lys Leu Asp Phe Thr He Asn Gly Asp Lys Arg Thr Gly

165 170 175

Gly Glu Pro Asn Lys Lys Leu Val Tyr Pro Trp Ser His Gly Lys Ala

180 185 190

He Ser Thr Ser Trp Asn Ala Thr He Thr Ala Pro Thr Thr Glu Asn

195 200 205

He Asn Thr Thr Asn Ser Ala Gin Glu Leu Leu Lys Gin Ala Ser He

210 215 220

He He Thr Thr Leu Asn Ser Ala Cys Pro Asn Phe Gin Asn Gly Gly 225 230 235 240

Ser Gly Tyr Trp Ala Gly He Ser Gly Asn Gly Thr Met Cys Gly Met

245 250 255

Phe Lys Asn Glu He Ser Ala He Gin Gly Met He Ala Asn Ala Gin

260 265 270

Glu Ala Val Ala Gin Ala Lys He Val Ser Glu Asn Thr Gin Asn Gin

275 280 285

Asn Ser Leu Asp Ala Gly Lys Pro Phe Asn Pro Tyr Thr Asp Ala Ser

290 295 300

Phe Ala Glu Ser Met Leu Lys Asn Ala Gin Ala Gin Ala Glu He Leu 305 310 315 320

Asn Gin Ala Glu Gin Val Val Lys Asn Phe Glu Lys He Pro Thr Ala

325 330 335

Phe Val Asn Asp Ser Leu Gly Val Cys Tyr Glu Val Gin Gly Gly Glu

340 345 350

Arg Arg Gly Thr Asn Pro Gly Gin Thr Thr Ser Asn Thr Trp Gly Ala

355 360 365

Gly Cys Ala Tyr Val Gly Gin Thr He Thr Asn Leu Lys Asn Ser He

370 375 380

Ala His Phe Gly Thr Gin Glu Gin Gin He Gin Gin Ala Glu Asn He 385 390 395 400

Ala Asp Thr Leu Val Asn Phe Lys Ser Arg Tyr Ser Glu Leu Gly Asn

405 410 415

Thr Tyr Asn Ser He Thr Thr Ala Leu Ser Asn He Pro Asn Ala Gin 420 425 430 Ser Leu Gin Asn Ala Val Ser Lys Lys Asn Asn Pro Tyr Ser Pro Gin

435 440 445

Gly He Asp Thr Asn Tyr Tyr Leu Asn Gin Asn Ser Tyr Asn Gin He

450 455 460

Gin Thr He Asn Gin Glu Leu Gly Arg Asn Pro Phe Arg Lys Val Gly 465 470 475 480

He Val Ser Ser Gin Thr Asn Asn Gly Ala Met Asn Gly He Gly He

485 490 495

Gin Val Gly Tyr Lys Gin Phe Phe Gly Gin Lys Arg Lys Trp Gly Ala

500 505 510

Arg Tyr Tyr Gly Phe Phe Asp Tyr Asn His Ala Phe He Lys Ser Ser

515 520 525

Phe Phe Asn Ser Ala Ser Asp Val Trp Thr Tyr Gly Phe Gly Ala Asp

530 535 540

Ala Leu Tyr Asn Phe He Asn Asp Lys Ala Thr Asn Phe Leu Gly Lys 545 550 555 560

Asn Asn Lys Leu Ser Val Gly Leu Phe Gly Gly He Ala Leu Ala Gly

565 570 575

Thr Ser Trp Leu Asn Ser Glu Tyr Val Asn Leu Ala Thr Met Asn Asn

580 585 590

Val Tyr Asn Ala Lys Met Asn Val Ala Asn Phe Gin Phe Leu Phe Asn

595 600 605

Met Gly Val Arg Met Asn Leu Ala Arg Pro Lys Lys Lys Asp Ser Asp

610 615 620

His Ala Ala Gin His Gly He Glu Leu Gly Leu Lys He Pro Thr He 625 630 635 640

Asn Thr Asn Tyr Tyr Ser Phe Met Gly Ala Glu Leu Lys Tyr Arg Arg

645 650 655

Leu Tyr Ser Val Tyr Leu Asn Tyr Val Phe Ala Tyr 660 665

(2) INFORMATION FOR SEQ ID NO: 1064:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 342 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...342

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 1064 :

Leu Thr Lys Lys Phe Met Ser Trp Met Val Val He Gly Ala Leu He

1 5 10 15

Cys Val Leu Leu Gly Val Phe He Phe Phe Thr Ser Met Ser Val Lys

20 25 30

Lys Ser Leu Thr Ala Tyr Leu Asn Ala Tyr Leu Glu Gin Arg Pro Asn 35 40 45 He Glu Gly Met Gly He He Gly Val Pro Phe Lys Cys Glu Gly Phe

50 55 60

Phe Lys He Ala Cys Val Ser Lys Glu Leu Arg Phe Leu Asp Pro Gin 65 70 75 80

Asn Ser Pro He Met Asp Phe Lys Asn Leu Lys He Lys Leu His Ser

85 90 95

Leu Asp Lys Ser Ser Leu Thr Leu Ser He His Ser Gin He Gin Ser

100 105 110

Pro He Leu Glu Gin Ser He Gin Gin Lys He Ser Gin He Pro Leu

115 120 125

Lys Asn Leu Asn Ala Leu Leu Glu Lys Phe Lys Pro Thr Arg Leu Asn

130 135 140

Cys Ser Leu Thr Phe Asn Ala Leu Asp Glu Lys Thr Leu Asn Asp Asn 145 150 155 160

Leu Lys Cys Asp Leu Thr Asn Ala Glu Asn He Leu Ala Tyr Thr Phe

165 170 175

Phe Gin Glu Gly Leu Met Glu Ala Gin Glu Asn Leu Ser Leu Lys Asn

180 185 190

He Phe Lys Thr Leu Ser Ser Lys Asp Ala Lys Ala He Glu Glu Leu

195 200 205

Gin Asp Lys Leu Arg Phe Leu Ala Pro Lys Leu Ser Val Ser He Gin

210 215 220

Ala Arg His Phe Lys Asn Val Leu Glu Ser Phe Tyr Gin Gin Asn Lys 225 230 235 240

Glu Ser Leu Gly Phe Phe Ser Pro Tyr Phe Ser Leu Arg Ser Gin Thr

245 250 255

Pro Ser Val Ser Tyr Glu Ser Ala Leu Ala Ser Leu Glu Asn Tyr Phe

260 265 270

Met Ala Leu Phe Gin Ser His Phe Lys Asp Asp Thr Ala Leu Gin Gin

275 280 285

Asn Phe Lys Gly Leu Leu Gin Ala Phe Val Ser Met Ala Lys Asp Lys

290 295 300

Arg Ser Gin He Val Leu Asn Ala Gin Ala Lys Asp Asn Thr Lys Leu 305 310 315 320

Thr Phe Asn Ala Leu Leu Glu Ser Leu Ser Val Asn Phe Phe Gin Ser

325 330 335

340

(2) INFORMATION FOR SEQ ID NO: 1065.

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 293 ammo acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(ill) HYPOTHETICAL : YES

(Vl) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE.

(A) NAME/KEY: miscjeature

(B) LOCATION 1...293 (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1065:

Met Arg Leu Leu Phe Leu Leu Leu Ser Ala Thr Leu Met Leu Leu Ala

1 5 10 15

Glu Glu Lys He Pro Leu Ser Asp Asp Ala Pro He Lys Leu Val His

20 25 30

Trp Gin Asn Ala Leu Lys Glu Val Gin Pro Asp Ser Asn Ala Pro Ala

35 40 45

Thr Pro Pro He Lys Ala Val Gin Thr Thr Leu Thr Phe Glu Thr Pro

50 55 60

Phe Asn Lys Thr Pro Lys He Met Glu Val Glu Gly Gin Lys Val He 65 70 75 80

Val Leu Lys Asn Ala Gin Leu Asp Ser Lys Lys Thr Met Asp Phe Lys

85 90 95

Glu Ala Ser Leu Asn Ala Leu Glu Met Phe Ser Tyr Gin Asn Asp He

100 105 110

Tyr Leu Leu Ser Lys Lys Ala Lys Ala Gly Leu Glu He Gin Ala Ser

115 120 125

Ser Ser Lys Asp Lys Lys Gin Leu Arg Phe Leu Phe Leu Pro Lys Gly

130 135 140

Phe His Leu Ala Pro Pro Pro Ser Leu Lys Glu Lys Ser Gin His Ala 145 150 155 160

Asn Leu Ala Ser Gin Asp Glu Lys Glu Arg Ala Lys Ser Pro Ser Asn

165 170 175

Ala Leu Glu Leu Lys Pro Pro Leu Asp Leu Ser His Ala Tyr Lys Gly

180 185 190

Leu Ala Val He Ala Val Leu Leu Leu He Leu Tyr Val He Lys Lys

195 200 205

Lys He Val Pro Thr Pro Gly Ser Phe Leu Lys Lys Asp Leu Lys Leu

210 215 220

Asp He Ser Val Leu Gly Arg Val Asp Ala Asn His Lys He He Ser 225 230 235 240

He Glu Thr Asn Lys Glu Arg Tyr Leu Val Leu Leu Ser Asp Lys Tyr

245 250 255

Gly Leu Leu Leu Asp Lys He Ser Pro Lys Thr Ser Lys Glu Glu Leu

260 265 270

He Lys Glu Ala Glu Asn Lys He Lys Asn Ser Lys Leu Gly Asn Leu

275 280 285

Tyr Ala Gly Lys Phe 290

(2) INFORMATION FOR SEQ ID NO: 1066:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 286 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL : YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature ( B ) LOCATION 1 . . 286

( xi ) SEQUENCE DESCRI PTION . SEQ ID NO : 1066 .

Met Leu Arg Asn Gin Phe Arg He Val Phe Val Ser Cys He Val Al a

1 5 10 15

Ser Ser Leu Gin Ala Gin Glu Asn Thr His Thr Leu Gly Lys Val Thr

20 25 30

Thr Lys Gly Glu Arg Thr Phe Glu Tyr Asn Asn Lys Met Tyr He Asp

35 40 45

Arg Lys Glu Leu Gin Gin Arg Gin Ser Asn Gin He Arg Asp He Phe

50 55 60

Arg Thr Arg Ala Asp Val Asn Val Ala Ser Gly Gly Leu Met Ala Gin 65 70 75 80

Lys He Tyr Val Arg Gly He Glu Ser Arg Leu Leu Arg Val Thr He

85 90 95

Asp Gly Val Ala Gin Asn Gly Asn He Phe His His Asp Ala Asn Thr

100 105 110

Val He Asp Pro Asn Met He Lys Glu Val Glu Val He Lys Gly Ala

115 120 125

Ala Asn Ala Ser Ala Gly Pro Gly Ala Val Ala Gly Lys Leu Ser Phe

130 135 140

Thr Thr He Asp Ala Asn Asp Phe Leu Arg Lys Asn Gin Thr Tyr Gly 145 150 155 160

Ala Lys Ala Glu Ala Ala Phe Tyr Thr Asn Phe Gly Tyr Arg Met Asn

165 170 175

Ala Thr Ala Ala Tyr Arg Gly Lys Asn Trp Asp He Leu Ala Tyr Tyr

180 185 190

Asn His Gin Asn He Phe Tyr Tyr Arg Asp Gly Asn Asn Ala Phe Arg

195 200 205

Ser Leu Phe His Pro Asn Tyr Asp Leu Gin Asp Pro Ser Asn Ser Glu

210 215 220

Met Ser Val Gly Thr Pro Ser Glu Val Asn Ser Val Leu Ala Lys He 225 230 235 240

Asn Gly Tyr He Asn Glu Thr Asp Ser He Ser Val Ser Tyr Asn Leu

245 250 255

Thr Arg Asp Asn Ser Thr Arg Leu Leu Arg Pro Asn Thr Thr Ser Ala

260 265 270

Leu Ser Lys Ala Asn Asp Gin Glu Ala Ser Gin Pro Pro Leu 275 280 285

(2) INFORMATION FOR SEQ ID NO: 1067:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 341 ammo acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature (B) LOCATION 1...341

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1067:

Met Lys Arg Leu Leu Leu Leu Ala Leu Ala Leu Phe Phe Ser Leu Ser

1 5 10 15

Cys Thr Asn Ala Gin Glu He Lys Glu Thr Gin Glu Thr Lys Lys Thr

20 25 30

Lys Glu Thr Lys Ser Gin Thr Arg Phe Asn He Ser Thr Thr Lys Val

35 40 45

He Glu Lys Glu Phe Ser Gin Ser Arg Arg Tyr Tyr Ala Leu Leu Glu

50 55 60

Pro Asn Glu Ala Leu He Phe Ser Gin Thr Leu Arg Phe Asp Gly Tyr 65 70 75 80

Val Glu Lys Leu Tyr Ala Asn Lys Thr Tyr Thr Pro He Lys Lys Gly

85 90 95

Asp Arg Leu Leu Ser Val Tyr Ser Pro Glu Leu Ala Gly Val Gin Ser

100 105 110

Glu Leu Leu Ser Ser Leu Lys Phe Asn Gin Gin Val Gly Ala He Lys

115 120 125

Glu Lys Leu Lys Leu Leu Gly Leu Glu Asn Phe Ser He Glu Lys He

130 135 140

He Ser Ser His Lys Val Gin Asn Glu He Thr He Tyr Ser Arg Phe 145 150 155 160

Asn Gly Val He Phe Lys Lys Ser Pro Asp Leu Asn Glu Gly Ser Phe

165 170 175

He Lys Lys Gly Gin Glu Leu Phe Lys He He Asp Leu Ser Arg Leu

180 185 190

Trp Ala Leu Val Lys Val Asn Gin Glu Asp Leu Glu Phe Leu Lys Asn

195 200 205

Thr His Gin Ala He Leu Phe Val Glu Gly Val Lys Gly Lys Gin Ala

210 215 220

He Thr Leu Glu Asn He Asn Pro He He Asn Ala Gin Asp Lys Met 225 230 235 240

Leu Glu Ala Arg Phe Asn Val Pro Asn Leu Lys Leu Leu Tyr Tyr Pro

245 250 255

Asn Met Phe Ala Gin Val Glu He Phe His Lys Pro Gin Lys Met Lys

260 265 270

He Leu Pro Lys Glu Ala Val Leu He Lys Gly Gly Lys Ala He Val

275 280 285

Phe Lys Lys Asp Asp Phe Gly Leu Ser Pro Leu Glu He Lys Ala Val

290 295 300

Arg Leu Ser Asp Gly Ser Tyr Glu He Leu Glu Gly Leu Lys Ala Gly 305 310 315 320

Glu Glu Val Ala Asn Asn Ala Leu Phe Val Leu Asp Ala Asp Ala Gin

325 330 335

Asn Asn Gly Asp Tyr 340

(2) INFORMATION FOR SEQ ID NO: 1068:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 463 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL : YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...463

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 1068 :

Met Ala Phe Cys Ala Arg Gin Lys Pro Leu Lys Glu He Met Arg Phe

1 5 10 15

Phe He Leu Phe Phe Met Gly Met Leu Gly Val Gly Phe Ser Gin Thr

20 25 30

Glu Leu Asp Leu Lys Asp Leu Glu Lys Lys Pro Ala Gly He Val Arg

35 40 45

Asp Tyr Tyr Leu Trp Arg Tyr He Ser Asp Lys Lys Thr Ser Leu Glu

50 55 60

Asn Ala Lys Lys Ala Tyr Glu Leu Thr Gin Asn Lys Asn Ser Ala Leu 65 70 75 80

Gin Lys Ala Met Gin Glu Lys Gly Val Glu Asn Ser Asp Lys Ser Pro

85 90 95

Asp Ala Lys Met Pro Glu Asp He Tyr Cys Lys Gin He Thr Leu Glu

100 105 110

Ser Met Leu Glu Thr Thr Asp Ala Phe Gin Ala Ser Cys He Ala He

115 120 125

Ala Leu Lys Ser Lys He Arg Asp Phe Asp Lys He Pro He Gin Thr

130 135 140

Phe Lys Pro Leu Gin Glu Lys He Lys Glu Ala Tyr Pro He Leu Tyr 145 150 155 160

Glu Glu Leu Glu He Leu Gin Ser Lys Asn Val Ser Ala Ser Leu Phe

165 170 175

Lys Ala Asn Ala Gin Val Phe Ser Ala Leu Phe Asn His Leu Ser Tyr

180 185 190

Glu Lys Lys Leu Gin He Phe Glu Lys His He Pro He Lys Glu Leu

195 200 205

Asn Arg Leu Leu Asp Glu Asp Tyr Pro Ala Phe Asn Arg Leu He Tyr

210 215 220

Gin Val He Leu Asp Pro Lys Leu Asp His Phe Lys Asp Ala Leu Ala 225 230 235 240

Lys Ser Asn Ala Thr Gin Ser Asn Ala Gin Thr Phe Phe He Leu Gly

245 250 255

He Asn Glu He Leu His Lys Lys Thr Ser Lys Ala Leu Lys Tyr Phe

260 265 270

Glu Arg Ser Glu Ala Val Val Lys Asp Asp Asp Phe Ser Lys Asp Arg

275 280 285

Ala He Phe Trp Gin Tyr Leu Ala Ser Lys Lys Lys Lys Thr Leu Glu

290 295 300

His Leu Ser Gin Ser Pro Ala Leu Asn Leu Tyr Ser Leu Tyr Ala Ser 305 310 315 320

Arg Lys Leu Lys Thr Thr Pro Ser Tyr Arg He He Ser His He Gin

325 330 335

Asn Leu Ser Gin Glu Asn Pro Pro Phe Asn Thr Tyr Asp Pro Phe Ser

340 345 350

Trp Gin He Phe Lys Glu Lys Thr Leu Ser Leu Lys Asp Glu Gly Ala 355 360 365

Phe Asn Ala Met Leu Lys Ser Leu Tyr Tyr Glu Lys Ser Ala Pro Glu

370 375 380

Leu Thr Tyr Leu Leu Ser Gin Arg Asn Lys Asp Lys He Tyr Tyr Tyr 385 390 395 400

Leu Ser Pro Tyr Glu Gly He He Glu Trp Gin Asn Thr Asp Glu Arg

405 410 415

Ala Met Ala Tyr Ala He Ala Arg Gin Glu Ser Phe Leu Leu Pro Ala

420 425 430

Leu He Ser Arg Ser Phe Ala Leu Gly Leu Met Gin He Met Pro Phe

435 440 445

Asn Val Gly Pro Phe Ala Lys Ala Leu Ala Trp He Met Leu He 450 455 460

(2) INFORMATION FOR SEQ ID NO: 1069:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 374 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...374

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1069:

Met Pro Lys Arg Met Lys Cys Phe Ser Gin Lys Trp Leu Val Phe Phe

1 5 10 15

Val Thr His Trp Leu Leu Leu Ala Ser Leu Ser His Ala Lys Met Ala

20 25 30

Phe Glu Ser Asn He Asp Thr Lys Ala Leu Glu Ala Phe Gly Val Asn

35 40 45

Ala Ser Phe Leu Ser Gin Met Pro Gly Ala Leu Lys Lys Val Asn Lys

50 55 60

Glu Glu Glu Trp Lys Lys Leu Val Lys Arg Phe Asp Val Asn Tyr Gin 65 70 75 80

Phe He Pro He He Lys Asn Met Leu He Gly Ala Ser Val Pro Gin

85 90 95

Glu Phe Leu Phe Leu Ala Met Ala Glu Ser Lys Phe Ser Ser Arg Ala

100 105 110

Tyr Ser Arg Lys Lys Ala Val Gly He Trp Gin Phe Met Pro Ser Thr

115 120 125

Ala Lys Glu Leu Gly Leu Lys Val Asn His Tyr He Asp Glu Arg Arg

130 135 140

Asp Pro He Lys Ser Thr Gin Ala Ala He Ala Tyr Leu Lys Arg Leu 145 150 155 160

Tyr Lys Gin Thr Gly Glu Trp Tyr Leu Val Ala Met Ala Tyr Asn Tyr

165 170 175

Gly Leu Arg Lys Val Gin Asn Ala He Lys Ala Ala Gly Thr Ser Asp 180 185 190

He Lys Val Leu Leu Asp Glu Asp Lys Lys Tyr Leu Pro Lys Glu Thr

195 200 205

Arg Glu Tyr He Arg Ser He Leu Ser Leu Ala Leu Lys Phe Asn Ser

210 215 220

Leu Asp Asn Leu Lys Asp Lys Glu Tyr Leu Leu Asn Arg Gly Ala Arg 225 230 235 240

Val Ser Leu Val Gly Val Pro Phe Lys Arg His Thr Ser Leu Val Gin

245 250 255

Val Ala Lys Asn Leu Asn Leu Ser Leu Glu Thr Leu Lys Ser Tyr Asn

260 265 270

His Gin Phe Arg Tyr Asn He Leu Pro Ser Lys Asp Pro Thr Tyr Thr

275 280 285

He Tyr He Pro Tyr Glu Lys Leu Ala Leu Phe Lys Gin Arg Gin Leu

290 295 300

Lys Gin Asn Lys Asn Ala Gin Ala Asn Pro Lys Ser Pro Phe He Thr 305 310 315 320

His Val Val Leu Pro Lys Glu Thr Leu Ser Ser He Ala Lys Arg Tyr

325 330 335

Gin Val Ser He Ser Ser He Gin Leu Ala Asn Asn Leu Lys Asp Ser

340 345 350

Asn He Phe He His Gin Arg Leu He He Pro Thr Asn Lys Lys Leu

355 360 365

Leu Ala Thr Arg Glu Phe 370

(2) INFORMATION FOR SEQ ID NO: 1070:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 333 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...333

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 1070 :

Met Leu He Ala Arg Phe Lys Lys Ala Leu He Ser Tyr Ser Leu Gly

1 5 10 15

Val Leu Leu Val Ser Ser Leu Leu Gly Val Ala Asn Ala Ser Asn Gin

20 25 30

Glu He Gin Val Lys Asp Tyr Phe Gly Glu Gin Thr He Lys Leu Pro

35 40 45

Val Ser Lys He He Tyr Leu Gly Ser Phe Ala Glu Val Pro Ala Met

50 55 60

Phe Asn Thr Trp Asp Arg Val Val Gly He Ser Asp Tyr Ala Phe Lys 65 70 75 80

Ser Asp He Val Lys Ala Thr Leu Lys Asp Pro Glu Arg He Lys Pro 85 90 95

Met Ser Ser Asp His Val Ala Ala Leu Asn Val Glu Leu Leu Lys Lys

100 105 110

Leu Ser Pro Asp Leu Val Val Thr Phe Val Gly Asn Pro Lys Ala Val

115 120 125

Glu His Ala Lys Lys Phe Gly He Ser Phe Leu Ser Phe Gin Glu Lys

130 135 140

Thr He Val Glu Val Met Glu Asp He Asp Ala Gin Ala Lys Ala Leu 145 150 155 160

Glu Val Asp Ala Ser Lys Lys Leu Ala Lys Met Gin Glu Thr Leu Asp

165 170 175

Phe He Lys Glu Arg Leu Lys Asn Val Lys Lys Lys Lys Gly Val Glu

180 185 190

Leu Phe His Lys Ala Asn Lys He Ser Gly His Gin Ala Leu Asp Ser

195 200 205

Asp He Leu Glu Lys Gly Gly He Asp Asn Phe Gly Leu Lys Tyr Val

210 215 220

Lys Phe Gly Arg Ala Asp He Ser Val Glu Lys He Val Lys Glu Asn 225 230 235 240

Pro Glu He He Phe He Trp Trp He Ser Pro Leu Ser Pro Glu Asp

245 250 255

Val Leu Asn Asn Pro Lys Phe Ser Thr He Lys Ala He Lys Asn Lys

260 265 270

Gin Val Tyr Lys Leu Pro Thr Met Asp He Gly Gly Pro Arg Ala Pro

275 280 285

Leu He Ser Leu Phe He Ala Leu Lys Ala His Pro Glu Ala Phe Lys

290 295 300

Gly Val Asp He Asn Ala He He Lys Asp Tyr Tyr Lys Val Val Phe 305 310 315 320

Asp Leu Asn Asp Ala Glu Val Glu Pro Phe Leu Trp His 325 330

(2) INFORMATION FOR SEQ ID NO: 1071:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 533 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...533

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 1071 :

Met Glu He Arg Asn He Lys Glu Phe Glu Lys Ala Ser Lys Lys Leu

1 5 10 15

Gin Lys Asp Thr Leu Lys He Ala Leu Ala Leu Leu Phe Leu He Gly

20 25 30

Ala Ala Leu Leu Ala Leu He Phe Gly Gin Ala Asn Ser Lys Gly Leu 35 40 45

Leu Leu He Phe Ala Ala Val He Gly Gly Tyr Met Ala Met Asn He

50 55 60

Gly Ala Asn Asp Val Ser Asn Asn Val Gly Pro Ala Val Gly Ser Lys 65 70 75 80

Ala He Ser Met Gly Gly Ala He Leu He Ala Ala Val Cys Glu Met

85 90 95

Leu Gly Ala He He Ala Gly Gly Glu Val Val Ser Thr He Lys Gly

100 105 110

Arg He Val Ser Pro Glu Phe He Asn Asp Ala His Val Phe He Asn

115 120 125

Val Met Leu Ala Ser Leu Leu Ser Gly Ala Leu Trp Leu His Val Ala

130 135 140

Thr Leu He Gly Ala Pro Val Ser Thr Ser His Ser Val Val Gly Gly 145 150 155 160

He Met Gly Ala Gly Met Ala Ala Ala Gly Met Ser Ala He Asn Trp

165 170 175

His Phe Leu Ser Gly He Val Ala Ser Trp Val He Ser Pro Leu Met

180 185 190

Gly Ala Leu He Ala Met Phe Phe Leu Met Leu He Lys Lys Thr He

195 200 205

Ala Tyr Lys Glu Asp Lys Lys Ser Ala Ala Leu Lys Val Val Pro Tyr

210 215 220

Leu Val Ala Leu Met Ser Leu Ala Phe Ser Trp Tyr Leu He Val Lys 225 230 235 240

Val Leu Lys Arg Leu Tyr Ala Val Gly Phe Glu He Gin Leu Ala Cys

245 250 255

Gly Cys Val Leu Ala Leu Leu He Phe He Leu Phe Lys Arg Phe Val

260 265 270

Leu Lys Lys Ala Pro Gin Leu Glu Asn Ser His Glu Ser Val Asn Glu

275 280 285

Leu Phe Asn Val Pro Leu He Phe Ala Ala Ala Leu Leu Ser Phe Ala

290 295 300

His Gly Ala Asn Asp Val Ala Asn Ala He Gly Pro Leu Ala Ala He 305 310 315 320

Ser Gin Thr Leu Glu Asp Ala Ser Ser Pro Met Gly Ser Thr Leu Asn

325 330 335

Ser Val Pro Leu Trp He Met Val Val Gly Ala Ala Gly He Ala Leu

340 345 350

Gly Leu Ser Leu Tyr Gly Pro Lys Leu He Lys Thr Val Gly Ser Glu

355 360 365

He Thr Glu Leu Asp Lys Met Gin Ala Phe Cys He Ala Leu Ser Ala

370 375 380

Val He Thr Val Leu Leu Ala Ser Gin Leu Gly Leu Pro Val Ser Ser 385 390 395 400

Thr His He Val Val Gly Ala Val Phe Gly Val Gly Phe Leu Arg Glu

405 410 415

Arg Leu Arg Glu Gin Ser Arg Arg Arg Phe Ala Arg He Arg Asp Asn

420 425 430

He Val Ala Ala His Phe Gly Glu Asp Leu Glu Glu He Glu Gly Phe

435 440 445

Leu Glu Arg Phe Asp Lys Ala Asn Leu Lys Glu Lys Ser Leu Met Leu

450 455 460

Glu Ser Leu Lys Lys Ser Lys Asn Thr Ala He Ala Leu Glu Leu Lys 465 470 475 480

Lys Lys Glu Lys Lys Ser Leu Lys Lys Val Tyr Lys Glu Glu Val He 485 490 495 Lys Arg Ser He Leu Lys Lys He Val Thr Ala Trp Leu Val Thr Val

500 505 510

Pro Val Ser Ala Leu Leu Gly Ala Leu Leu Phe Val Ala Leu Gly Phe

515 520 525

He Glu Lys Tyr Phe 530

(2) INFORMATION FOR SEQ ID NO: 1072:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 329 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 329

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 1072 :

Met Ser Asn Ser Met Leu Asp Lys Asn Lys Ala He Leu Thr Gly Gly

1 5 10 15

Gly Ala Leu Leu Leu Gly Leu He Val Leu Phe Tyr Leu Ala Tyr Arg

20 25 30

Pro Lys. Ala Glu Val Leu Gin Gly Phe Leu Glu Ala Arg Glu Tyr Ser

35 40 45

Val Ser Ser Lys Val Pro Gly Arg He Glu Lys Val Phe Val Lys Lys

50 55 60

Gly Asp Arg He Lys Lys Gly Asp Leu Val Phe Ser He Ser Ser Pro 65 70 75 80

Glu Leu Glu Ala Lys Leu Ala Gin Ala Glu Ala Gly His Lys Ala Ala

85 90 95

Lys Ala Val Ser Asp Glu Val Lys Arg Gly Ser Arg Asp Glu Thr He

100 105 110

Asn Ser Ala Arg Asp Val Trp Gin Ala Ala Lys Ser Gin Ala Asn Leu

115 120 125

Ala Lys Glu Thr Tyr Lys Arg Val Gin Asp Leu Tyr Asp Asn Gly Val

130 135 140

Ala Ser Leu Gin Lys Arg Asp Glu Ala Tyr Ala Ala Tyr Glu Ser Thr 145 150 155 160

Lys Tyr Asn Glu Ser Ala Ala Tyr Gin Lys Tyr Lys Met Ala Leu Gly

165 170 175

Gly Ala Ser Ser Glu Ser Lys He Ala Ala Lys Ala Lys Glu Ser Ala

180 185 190

Ala Leu Gly Gin Val Asn Glu Val Glu Ser Tyr Leu Lys Asp Val Lys

195 200 205

Ala Leu Ala Pro He Asp Gly Glu Val Ser Asn Val Leu Leu Ser Gly

210 215 220

Gly Glu Leu Ser Pro Lys Gly Phe Pro Val Val Leu Met He Asp Leu 225 230 235 240 Lys Asp Ser Trp Leu Lys He Ser Val Pro Glu Lys Tyr Leu Asn Glu

245 250 255

Phe Lys Val Gly Lys Glu Phe Glu Gly Tyr He Pro Ala Leu Lys Arg

260 265 270

Ser Ala Lys Phe Arg Val Lys Tyr Leu Ser Val Met Gly Asp Phe Ala

275 280 285

Thr Trp Lys Ala Thr Asn Asn Ser Asn Thr Tyr Asp Met Lys Ser Tyr

290 295 300

Glu Val Glu Ala He Pro Leu Glu Glu Leu Glu Asn Phe Arg Val Gly 305 310 315 320

Met Ser Val Leu Val Thr He Lys Pro 325

(2) INFORMATION FOR SEQ ID NO: 1073:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 292 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 292

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1073:

Arg Leu Glu Ser Pro Leu His Ser Gly Phe Ser Pro Ser Ala Ala Leu

1 5 10 15

Val He Ser Pro He Glu Pro Leu Ser Leu Lys He Thr Tyr Ser Gin

20 25 30

Val Thr Arg Gly Val Met Pro Gly Asp Gly Val Tyr Met Arg Gin Asn

35 40 45

Asp Leu Arg Tyr Ala Lys Asn He Lys Pro Glu Val Gly Ser Asn Ala

50 55 60

Glu Phe Asn He Asp Tyr Ser Ser Gin Tyr Phe Ser Gly Arg Ala Ala 65 70 75 80

Ala Phe Tyr Gin Ala Leu Asp Asn Phe He Ser Gin Tyr Ala Gin Arg

85 90 95

Leu He Val Thr Asn Leu Ser Gin Ala He Arg He Tyr Gly Tyr Glu

100 105 110

Val Gly Gly Thr Phe Arg Tyr Lys Gly Val Ser Leu Asn Val Gly He

115 120 125

Ser Arg Thr Trp Pro Thr Thr Arg Gly Tyr Leu Met Ala Asp Ser Tyr

130 135 140

Glu Leu Ala Ala Ser Thr Gly Asn Val Phe He He Lys Leu Asp Tyr 145 150 155 160

Thr He Pro Lys Thr Gly He Asn Leu Ala Trp Leu Ser Arg Phe Val

165 170 175

Thr Gly Leu Asp Tyr Cys Gly Phe Asp He Tyr Leu Pro Asp Tyr Gly 180 185 190 Thr Ala Glu Lys Pro Lys Thr Pro Thr Asp Leu Ala Lys Cys Gly Ser

195 200 205

Gin Leu Gly Leu Val His Met His Lys Pro Gly Tyr Gly Val Ser Asn

210 215 220

Phe Tyr He Asn Trp Ser Pro Lys Thr Lys Ser His Trp Lys Gly Leu 225 230 235 240

Leu Leu Ser Ala Val Phe Asn Asn Val Phe Asn Lys Phe Tyr Val Asp

245 250 255

Gin Thr Ser Pro Tyr Val Met Ser Pro Asp Met Pro Gly Thr Asp Ala

260 265 270

He Lys Arg Ala He Ala Glu Pro Gly Phe Asn Ala Arg Phe Glu Val

275 280 285

Ala Tyr Lys Trp 290

(2) INFORMATION FOR SEQ ID NO: 1074:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 484 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...484

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 1074 :

Met Ala Lys He Thr Thr Val He Asp He Gly Ser Asn Ser Val Arg

1 5 10 15

Leu Ala Val Phe Lys Lys Thr Ser Gin Phe Gly Phe Tyr Leu Leu Phe

20 . 25 30

Glu Thr Lys Ser Lys Val Arg He Ser Glu Gly Cys Tyr Ala Phe Lys

35 40 45

Gly Val Leu Gin Glu He Pro Met Gin Arg Ala Val Lys Ala Leu Ser

50 55 60

Glu Phe Lys Glu He Ala Leu Lys Tyr Lys Ser Lys Lys He Leu Cys 65 70 75 80

Val Ala Thr Ser Ala Val Arg Asp Ala Pro Asn Arg Leu Glu Phe Val

85 90 95

Ala Arg Val Lys Lys Ala Cys Gly Leu Gin He Lys He He Asp Gly

100 105 110

Gin Lys Glu Ala Leu Tyr Gly Gly He Ala Cys Ala Asn Leu Leu His

115 120 125

Lys Asn Ser Gly He Thr He Asp He Gly Gly Gly Ser Thr Glu Cys

130 135 140

Ala Leu He Glu Lys Gly Lys He Lys Asp Leu He Ser Leu Asp Val 145 150 155 160

Gly Thr He Arg He Lys Glu Met Phe Leu Asp Lys Asp Leu Asp Val 165 170 175 Lys Leu Ala Lys Ala Phe He Gin Lys Glu Val Ser Lys Leu Pro Phe

180 185 190

Lys His Lys Asn Ala Phe Gly Val Gly Gly Thr He Arg Ala Leu Ser

195 200 205

Lys Val Leu Met Lys Arg Phe Asp Tyr Pro He Asp Ser Leu His Gly

210 215 220

Tyr Glu He Asp Ala His Lys Asn Leu Ala Phe He Glu Lys He Val 225 230 235 240

Met Leu Lys Glu Asp Lys Leu Arg Leu Leu Gly Val Asn Glu Glu Arg

245 250 255

Leu Asp Ser He Arg Ser Gly Ala Leu He Leu Ser Val Val Leu Glu

260 265 270

His Leu Lys Thr Ser Leu Met He Thr Ser Gly Val Gly Val Arg Glu

275 280 285

Gly Val Phe Leu Ser Asp Leu Leu Arg His His Tyr His Lys Phe Pro

290 295 300

Pro Asn He Asn Pro Ser Leu He Ser Leu Lys Asp Arg Phe Leu Pro 305 310 315 320

His Glu Lys His Ser Gin Lys Val Lys Lys Glu Cys Val Lys Leu Phe

325 330 335

Glu Val Leu Ser Pro Leu His Lys He Asp Glu Lys Tyr Leu Phe His

340 345 350

Leu Lys He Ala Gly Glu Leu Ala Ser Met Gly Lys He Leu Ser Val

355 360 365

Tyr Leu Ala His Lys His Ser Ala Tyr Phe He Leu Asn Ala Leu Ser

370 375 380

Tyr Gly Phe Ser His Gin Asp Arg Ala He He Cys Leu Leu Ala Gin 385 390 395 400

Phe Ser His Lys Lys He Pro Lys Asp Asn Ala He Ala His Met Ser

405 410 415

Ala Met Met Pro Ser Leu Leu Thr Leu Gin Trp Leu Ser Phe He Leu

420 425 430

Ser Leu Ala Glu Asn Leu Cys Leu Thr Asp Ser His His Leu Lys Tyr

435 440 445

Thr Leu Glu Lys Asn Lys Leu Val He His Ser Asn Asp Ala Leu Tyr

450 455 460

Leu Ala Lys Glu Met Leu Pro Lys Leu He Lys Pro He Pro Leu Thr 465 470 475 480

He Glu Phe Ala

(2) INFORMATION FOR SEQ ID NO: 1075:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 222 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature ( B ) LOCATION 1 . . . 222

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 1075 :

Met Val Gly Met Lys Thr Glu Met Lys Ser Phe Leu Lys Leu Phe Ala

1 5 10 15

Gin Pro Leu Leu Val Val Leu Ala Phe Met Leu Leu Tyr Ala Leu Ala

20 25 30

His Ala Val Leu Gly Phe Tyr Val Lys Lys Asp Ser Ala Pro Met Ser

35 40 45

Pro Asn Val Glu Lys Ser Glu Thr Glu Arg Gin Asn Ser Thr Phe Ser

50 55 60

Pro Lys Glu Glu Ala Asn Ala Thr Thr Thr Ala Thr Glu Gin Asn Pro 65 70 75 80

Thr Lys Asp Thr Val Pro Pro Leu Asp Thr Ala Thr Gin Lys Gin Glu

85 90 95

He Lys Gin Glu He Lys Gin Glu He Lys Gin Glu He Lys Gin Glu

100 105 110

He Lys Gin Glu He Lys Gin Glu He Lys Gin Glu Thr Lys Gin Glu

115 120 125

Gin Glu Lys Glu Asn Lys Pro Lys Gin Asn Ser Val Ser Pro Val Gin

130 135 140

Asn Asp Gin Lys Thr Pro Thr Thr Pro Leu Met Gly Lys Lys Pro Leu 145 150 155 160

Glu Tyr Lys Val Ala Val Ser Gly Val Asn Val Arg Ala Phe Pro Ser

165 170 175

Thr Lys Gly Lys He He Gly Ser Leu He Lys Asn Lys Ser Val Lys

180 185 190

Val Leu Glu He Gin Asn Asp Trp Ala Glu He Glu Phe Ser His Glu

195 200 205

Thr Lys Gly Tyr Val Phe Leu Lys Leu Leu Lys Lys Ala Glu 210 215 220

(2) INFORMATION FOR SEQ ID NO: 1076:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 135 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME / KEY : miscjeature

( B ) LOCATION 1 . . . 135

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1076:

Glu Pro Asp Ala Thr Ser Arg Arg Thr Leu Asn His Pro Tyr Phe Gly 1 5 10 15

Val Phe Val Leu Leu Val Phe Thr Phe Trp Val Phe Asn Leu Thr Leu 20 25 30 Arg He Gin Arg Phe Leu Ser Arg Lys Met Ala Gin Lys Lys Gly Glu

35 40 45

Lys Leu Lys Leu Ala Pro Tyr Glu Cys Gly Pro Val Ala Leu Lys Gin

50 55 60

Pro Asn Arg Val Ser His His Phe Tyr He Met Ala Met Leu Phe He 65 70 75 80

Leu Phe Asp Val Glu He Val Phe Met Phe Pro Trp Ala He Asp Phe

85 90 95

Lys Lys Leu Gly Leu Phe Gly Leu Val Glu Met Leu Gly Phe Val Phe

100 105 110

Phe Leu Ala He Gly Phe He Tyr Ala Leu Lys Arg Asn Ala Leu Ser

115 120 125

Trp Gin Lys Leu Glu Val Lys 130 135

(2) INFORMATION FOR SEQ ID NO: 1077:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 635 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 635

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1077:

Leu Ser Ser Asp Pro Ser Ala Val Asn Asp Ala Arg Asp Asn Leu Gly

1 5 10 15

Ser Ser Thr Arg Asn Leu Leu Asp Val Lys Ala Asn Ser Pro Ala Tyr

20 25 30

Gin Ala Val Leu Leu Ala Leu Asn Ala Ala Val Gly Leu Trp Gin Val

35 40 45

Thr Ser Tyr Ala Phe Thr Ala Cys Gly Pro Gly Ser Asn Glu Asn Ala

50 55 60

Asn Gly Gly He Gin Thr Phe Asn Asn Val Pro Gly Gin Asn Thr Thr 65 70 75 80

Thr He Thr Cys Asn Ser Tyr Tyr Glu Pro Gly His Gly Gly Pro He

85 90 95

Ser Thr Lys Asn Tyr Ala He He Asn Lys Ala Tyr Gin He He Gin

100 105 110

Lys Ala Leu Thr Ala Asn Gly Glu Gly He Pro Val Leu Ser Asn Thr

115 120 125

Thr Thr Lys Leu Asp Phe Thr He Asn Gly Asp Lys Arg Thr Gly Gly

130 135 140

Glu Pro Asn Lys Lys Leu Val Tyr Pro Trp Ser His Gly Lys Ala He 145 150 155 160

Ser Thr Ser Trp Asn Ala Thr He Thr Ala Pro Thr Thr Glu Asn He 165 170 175 Asn Thr Thr Asn Ser Ala Gin Glu Leu Leu Lys Gin Ala Ser He He

180 185 190

He Thr Thr Leu Asn Ser Ala Cys Pro Asn Phe Gin Asn Gly Gly Ser

195 200 205

Gly Tyr Trp Ala Gly He Ser Gly Asn Gly Thr Met Cys Gly Met Phe

210 215 220

Lys Asn Glu He Ser Ala He Gin Gly Met He Ala Asn Ala Gin Glu 225 230 235 240

Ala Val Ala Gin Ala Lys He Val Ser Glu Asn Thr Gin Asn Gin Asn

245 250 255

Ser Leu Asp Ala Gly Lys Pro Phe Asn Pro Tyr Thr Asp Ala Ser Phe

260 265 270

Ala Glu Ser Met Leu Lys Asn Ala Gin Ala Gin Ala Glu He Leu Asn

275 280 285

Gin Ala Glu Gin Val Val Lys Asn Phe Glu Lys He Pro Thr Ala Phe

290 295 300

Val Asn Asp Ser Leu Gly Val Cys Tyr Glu Val Gin Gly Gly Glu Arg 305 310 315 320

Arg Gly Thr Asn Pro Gly Gin Thr Thr Ser Asn Thr Trp Gly Ala Gly

325 330 335

Cys Ala Tyr Val Gly Gin Thr He Thr Asn Leu Lys Asn Ser He Ala

340 345 350

His Phe Gly Thr Gin Glu Gin Gin He Gin Gin Ala Glu Asn He Ala

355 360 365

Asp Thr Leu Val Asn Phe Lys Ser Arg Tyr Ser Glu Leu Gly Asn Thr

370 375 380

Tyr Asn Ser He Thr Thr Ala Leu Ser Asn He Pro Asn Ala Gin Ser 385 390 395 400

Leu Gin Asn Ala Val Ser Lys Lys Asn Asn Pro Tyr Ser Pro Gin Gly

405 410 415

He Asp Thr Asn Tyr Tyr Leu Asn Gin Asn Ser Tyr Asn Gin He Gin

420 425 430

Thr He Asn Gin Glu Leu Gly Arg Asn Pro Phe Arg Lys Val Gly He

435 440 445

Val Ser Ser Gin Thr Asn Asn Gly Ala Met Asn Gly He Gly He Gin

450 455 460

Val Gly Tyr Lys Gin Phe Phe Gly Gin Lys Arg Lys Trp Gly Ala Arg 465 470 475 480

Tyr Tyr Gly Phe Phe Asp Tyr Asn His Ala Phe He Lys Ser Ser Phe

485 490 495

Phe Asn Ser Ala Ser Asp Val Trp Thr Tyr Gly Phe Gly Ala Asp Ala

500 505 510

Leu Tyr Asn Phe He Asn Asp Lys Ala Thr Asn Phe Leu Gly Lys Asn

515 520 525

Asn Lys Leu Ser Val Gly Leu Phe Gly Gly He Ala Leu Ala Gly Thr

530 535 540

Ser Trp Leu Asn Ser Glu Tyr Val Asn Leu Ala Thr Met Asn Asn Val 545 550 555 560

Tyr Asn Ala Lys Met Asn Val Ala Asn Phe Gin Phe Leu Phe Asn Met

565 570 575

Gly Val Arg Met Asn Leu Ala Arg Pro Lys Lys Lys Asp Ser Asp His

580 585 590

Ala Ala Gin His Gly He Glu Leu Gly Leu Lys He Pro Thr He Asn

595 600 605

Thr Asn Tyr Tyr Ser Phe Met Gly Ala Glu Leu Lys Tyr Arg Arg Leu

610 615 620

Tyr Ser Val Tyr Leu Asn Tyr Val Phe Ala Tyr 625 630 635

(2) INFORMATION FOR SEQ ID NO: 1078:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 174 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME / KEY : miscjeature

( B ) LOCATION 1 . . . 174

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 1078 :

He Lys Arg He He Lys Ser Asn Ala Ser Leu Asn Gin Leu Asn Thr

1 5 10 15

Thr Arg Tyr Asn Thr Pro Ser His Leu Phe Phe Lys Lys Gly Val Gly

20 25 30

Met Ala Thr He Gin Pro Phe Asn His Ser Thr He Gin Pro Phe Asn

35 40 45

His Ser Thr He Gin Pro Phe Asn His Ser He He Gin Ser Phe Asn

50 55 60

His Ser Thr He Gin Ala Thr Leu Pro Tyr Phe Tyr Asn Tyr Leu Ser 65 70 75 80

Phe Tyr Lys Asn Leu Phe Lys Asn Pro Leu Phe Phe He He Pro Pro

85 90 95

Phe He Asn Pro Phe He Asn Pro Phe He Asn Pro Phe He Asn Pro

100 105 110

Phe He Asn Pro Phe He Asn Pro Phe He Asn Pro Phe He Asn Pro

115 120 125

Phe He Asn Pro Phe He Asn Pro Phe He Asn Pro Phe He Asn Pro

130 135 140

Phe He Asn Pro Phe He Asn Pro Phe He Asn Pro Phe He Ser Pro 145 150 155 160

Ser Leu Thr His Ala Thr Thr Phe Ser Asn His Leu He Pro 165 170

(2) INFORMATION FOR SEQ ID NO: 1079:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 748 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE: (A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...748

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 1079 :

Met Glu Asp Phe Leu Tyr Asn Thr Leu Tyr Phe He Glu Asp Tyr Lys

1 5 10 15

Leu Val Val He Phe Ser Phe He Gly Leu He Ala Leu Phe Phe Leu

20 25 30

Tyr Lys Phe He Lys Thr Gin Lys Lys Val Phe Lys Asp Lys Ala Asn

35 40 45

Gin Pro Gin Lys Lys Lys Ser Phe Lys Glu He He He Asp Gly Leu

50 55 60

Lys Glu Arg Val Lys Thr Phe Gly Phe Trp Leu Gin Ala He Leu Leu 65 70 75 80

Leu Ser Tyr Ser Phe He Thr Ser Gly Leu Phe Phe Leu He Leu Leu

85 90 95

Gly Asn Phe Tyr Asp Asp Asn Arg Leu Pro Glu Ser Asp Asp Asp Leu

100 105 110

Phe Asp He Trp Val Tyr Ala He Gin Asp Phe Pro Ala Tyr Tyr Phe

115 120 125

Lys Ala Leu Thr Phe Ser Ser Leu Lys He Tyr Gly Phe Asn He Ser

130 135 140

Leu Val Val Tyr Ser Ser He Leu Cys Ser Tyr He Phe He Thr Phe 145 150 155 160

Phe Val Trp Phe Leu Lys Tyr Leu Thr Arg Thr Arg Asp He Gly Ala

165 170 175

Asn Lys Lys Val Asp Asp Leu Phe Gly Ser Ala Ser Trp Glu Thr Glu

180 185 190

Glu Lys Met He Lys Ala Lys Leu He Thr Pro Asn Asn Lys Lys Arg

195 200 205

Ala Phe Asp Lys Arg Glu Val He Val Gly Arg Arg Gly Leu Gly Asp

210 215 220

Phe He Ala Tyr Ala Gly Gin Ala Phe He Gly Leu He Ala Pro Thr 225 230 235 240

Arg Ser Gly Lys Gly Val Gly Phe He Met Pro Asn Met He Asn Tyr

245 250 255

Pro Gin Asn He Val Val Phe Asp Pro Lys Ala Asp Thr Met Glu Thr

260 265 270

Cys Gly Lys He Arg Glu Lys Arg Phe Asn Gin Lys Val Phe He Tyr

275 280 285

Glu Pro Phe Ser Leu Lys Thr His Arg Phe Asn Pro Phe Ala Tyr Val

290 295 300

Asp Phe Gly Asn Asp Val Val Leu Thr Glu Asp He Leu Ser Gin He 305 310 315 320

Asp Thr Arg Leu Lys Gly His Gly Met Val Ala Ser Gly Gly Asp Phe

325 330 335

Ser Thr Gin He Phe Gly Leu Ala Lys Leu Val Phe Pro Glu Arg Pro

340 345 350

Asn Glu Lys Asp Pro Phe Phe Ser Asn Gin Ala Arg Asn Leu Phe Val

355 360 365

He Asn Cys Asn He Tyr Arg Asp Leu Met Trp Thr Lys Lys Gly Leu

370 375 380

Glu Phe Val Lys Arg Lys Lys He He Met Pro Glu Thr Pro Thr Met 385 390 395 400

Phe Phe He Gly Ser Met Ala Ser Gly He Asn Leu He Asp Glu Asp

405 410 415

Thr Asn Met Glu Lys Val Val Ser Leu Met Glu Phe Phe Gly Gly Glu

420 425 430

Glu Asp Lys Ser Gly Asp Asn Leu Arg Ala Leu Ser Pro Ala Thr Arg

435 440 445

Asn Met Trp Asn Asn Phe Lys Thr Met Gly Gly Ala Lys Glu Thr Tyr

450 455 460

Ser Ser Val Gin Gly Val Tyr Thr Ser Ala Phe Ala Pro Tyr Asn Asn 465 470 475 480

Ala Met He Arg Asn Phe Thr Ser Ala Asn Asp Phe Asp Phe Arg Arg

485 490 495

Leu Arg He Asp Ala Val Ser He Gly Val He Ala Asn Pro Lys Glu

500 505 510

Ser Thr He Val Gly Pro He Leu Glu Leu Phe Phe Asn Val Met He

515 520 525

Tyr Ser Asn Leu He Leu Pro He His Asp Pro Gin Cys Lys Arg Ser

530 535 540

Cys Leu Met Leu Met Asp Glu Phe Thr Leu Cys Gly Tyr Leu Glu Thr 545 550 555 560

Phe Val Lys Ala Val Gly He Met Ala Glu Tyr Asn Met Arg Pro Ala

565 570 575

Phe Val Phe Gin Ser Lys Ala Gin Leu Glu Asn Asp Pro Pro Leu Gly

580 585 590

Tyr Gly Arg Asn Gly Ala Lys Thr He Leu Asp Asn Leu Ser Leu Asn

595 600 605

Met Tyr Tyr Gly He Asn Asn Asp Asn Tyr Tyr Glu His Phe Glu Lys

610 615 ^' 620

Leu Ser Lys Val Leu Gly Lys Tyr Thr Arg Gin Asp Val Ser Arg Ser 625 630 635 640

He Asp Asp Asn Thr Gly Lys Thr Asn Thr Ser He Ser Asn Lys Glu

645 650 655

Arg Phe Leu Met Thr Pro Asp Glu Leu Met Thr Met Gly Asp Glu Leu

660 665 670

He He Leu Glu Asn Thr Leu Lys Pro He Lys Cys His Lys Ala Leu

675 680 685

Tyr Tyr Asp Asp Pro Phe Phe Thr Asp Glu Leu He Lys Val Ser Pro

690 695 700

Ser Leu Ser Lys Lys Tyr Lys Leu Gly Lys Val Pro Asn Gin Ala Thr 705 710 715 720

Phe Tyr Asp Asp Leu Gin Ala Ala Lys Thr Arg Gly Glu Leu Ser Tyr

725 730 735

Asp Lys Ser Leu Val Pro Val Gly Ser Ser Glu Leu 740 745

(2) INFORMATION FOR SEQ ID NO: 1080:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 404 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...404

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 1080 :

Leu Asn Ala Lys Ser Gin Ser Ser Leu Lys Asn Lys He Thr Leu Lys

1 5 10 15

Asn Lys Leu Asn His Ala Arg He He Leu Glu Phe He Pro Ser Leu

20 25 30

He Tyr Phe Leu He Gin Lys Val Ser Val Leu Lys His Leu Ala Pro

35 40 45

Leu He His He Pro Phe Lys Ala Leu Trp Leu Gly Thr Ala Leu Ser

50 55 60

Met Phe Leu Ser Leu Asn Leu Asn Ala Glu Glu Asn Pro Thr Lys Thr 65 70 75 80

Glu Pro Lys Pro Ala Lys Gly Val Lys Asn Lys Pro Lys Ser Pro Val

85 90 95

Thr Asn Val Met Met Thr Asn Cys Asp Asn Leu Lys Asp Phe Asn Ala

100 105 110

Lys Gin Lys Glu Val Leu Lys Ala Ala Tyr Gin Phe Gly Ser Lys Glu

115 120 125

Asn Leu Gly Tyr Glu Met Ala Gly He Ala Trp Lys Glu Ser Cys Ala

130 135 140

Gly Thr Tyr Lys He Asn Phe Ser Asp Pro Ser Ala Gly He Tyr His 145 150 155 160

Ala Tyr He Pro Ser Val Leu Lys Ser Tyr Gly His Asn Asn Ser Pro

165 170 175

Phe Leu Arg Asn Val Met Gly Glu Leu Leu He Lys Asp Asp Ala Phe

180 185 190

Ala Ser Glu Val Ala Leu Lys Glu Leu Leu Tyr Trp Lys Thr Arg Tyr

195 200 205

His Asp Asn Leu Lys Asp Met He Lys Ser Tyr Asn Lys Gly Ser Arg

210 215 220

Trp Glu Lys Asn Glu Lys Ala Asn Ala Asp Ala Glu Lys Tyr Tyr Glu 225 230 235 240

Glu He Gin Asp Arg He Arg Arg Leu Lys Glu Ser Lys He Phe Asp

245 250 255

Ser Gin Ser Ser Asn Asp Gin Glu Leu Gin Lys Ser Ala Asn Ser Asn

260 265 270

Leu Asp Leu Asp Pro He Gly Asn Ala Met Pro Gin Thr Leu Ala Gin

275 280 285

Thr Glu Thr Gin Lys Ser Gin He Glu Lys Ser Gin He Glu Glu Ala

290 295 300

Gin Thr Gin Lys Ser Gin Glu Met Lys Glu Ala Ala Ser Glu Gin Ala 305 310 315 320

He Lys Lys Pro Leu Glu Lys Glu Lys Asp Lys Pro Met Tyr Leu Ala

325 330 335

Gin He Asn Ser Ala Asp Phe Ala Pro Ala Lys Lys Ser Pro Lys Lys

340 345 350

Pro Ala Lys Ala Ser Pro Lys Arg Ser Ser Lys Asn Asn He Ser Val

355 360 365

Lys Ser Asn Thr Lys Thr Ala Ser Lys Asn Lys Glu Val Cys Lys Asn 370 375 380 Cys Ser Pro Gly Gin Arg Asn Ala He Leu Ala Asn His He Thr Leu 385 390 395 400

Met Gin Glu Leu

(2) INFORMATION FOR SEQ ID NO: 1081:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 270 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 270

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1081:

Met Lys Lys Phe Val Val Phe Lys Thr Leu Cys Leu Ser Val Val Leu

1 5 10 15

Gly Asn Ser Leu Val Ala Ala Glu Gly Ser Thr Glu Val Gin Lys Gin

20 25 30

Leu Glu Lys Pro Lys Asp Tyr Lys Ala Val Lys Gly Glu Lys Asn Ala

35 40 45

Trp Tyr Leu Gly He Ser Tyr Gin Val Gly Gin Ala Ser Gin Ser Val

50 55 60

Lys Asn Pro Pro Lys Ser Ser Glu Phe Asn Tyr Pro Lys Phe Pro Val 65 70 75 80

Gly Lys Thr Asp Tyr Leu Ala Val Met Gin Gly Leu Gly Leu Thr Val

85 90 95

Gly Tyr Lys Gin Phe Phe Gly Glu Lys Arg Trp Phe Gly Ala Arg Tyr

100 105 110

Tyr Gly Phe Met Asp Tyr Gly His Ala Val Phe Gly Ala Asn Ala Leu

115 120 125

Thr Ser Asp Asn Gly Gly Val Cys Lys Leu Asn Glu Pro Cys Ala Thr

130 135 140

Lys Val Gly Thr Met Gly Asn Leu Ser Asp Met Phe Thr Tyr Gly Val 145 150 155 160

Gly He Asp Thr Leu Tyr Asn Val He Asn Lys Glu Asp Ala Ser Phe

165 170 175

Gly Phe Phe Phe Gly Ala Gin He Ala Gly Asn Ser Trp Gly Asn Thr

180 185 190

Thr Gly Ala Phe Leu Glu Thr Lys Ser Pro Tyr Lys His Thr Ser Tyr

195 200 205

Ser Leu Asp Pro Ala He Phe Gin Phe Leu Phe Asn Leu Gly He Arg

210 215 220

Thr His He Gly Gin His Gin Glu Phe Asp Phe Gly Val Lys He Pro 225 230 235 240

Thr He Asn Val Tyr Tyr Phe Asn His Gly Asn Leu Ser Phe Thr Tyr 245 250 255 Arg Arg Gin Tyr Ser Leu Tyr Val Gly Tyr Arg Tyr Asn Phe 260 265 270

(2) INFORMATION FOR SEQ ID NO:1082:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 252 amino acids (3) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...252

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1082:

Met Lys Pro Tyr Phe Ser Leu Glu Lys Leu Asp Leu Tyr His Gly Asp

1 5 10 15

Ala Ser Val Leu Glu Thr Phe Glu Lys Gly Phe Tyr Asp Leu Cys Val

20 25 30

Thr Ser Pro Pro Tyr Asn Leu Ser He Glu Tyr Gin Gly Ser Asn Asp

35 40 45

Phe Arg Ala Tyr Asp Asp Tyr Leu Asn Trp Cys Lys Asn Trp Leu Lys

50 55 60

Asn Cys Tyr Phe Trp Gly Lys Glu Gin Ala Arg Leu Cys Leu Asn Val 65 70 75 80

Pro Leu Asp Thr Asn Lys His Gly Lys Gin Ser Leu Gly Ala Asp He

85 90 95

Thr He Val Ala Lys Glu Cys Gly Trp Lys Tyr Gin Asn Thr He He

100 105 110

Trp Asn Glu Ser Asn He Ser Arg Arg Thr Ala Trp Gly Ser Trp Leu

115 120 125

Gin Ala Ser Ala Pro Tyr Ala He Ala Pro Val Glu Leu He Val Val

130 135 140

Phe Tyr Lys Asn Glu Tyr Lys Arg Lys Lys Gin Thr Ser Thr Met Ser 145 150 155 160

Arg Glu Glu Phe Leu Leu Tyr Thr Asn Gly Leu Trp Asn Phe Ser Gly

165 170 175

Glu Ser Lys Lys Arg Leu Lys His Pro Ala Pro Phe Pro Arg Glu Leu

180 185 190

Pro Arg Arg Cys He Gin Leu Phe Ser Phe Leu Glu Asp Thr He Phe

195 200 205

Asp Pro Phe Ser Gly Ser Gly Thr Thr He Leu Glu Ala Asn Ala Leu

210 215 220

Gly Arg Phe Ser Val Gly Leu Glu He Glu Lys Glu Tyr Cys Glu Leu 225 230 235 240

Ser Lys Lys Arg He Leu Glu Ser Leu Ser Leu Val 245 250

(2) INFORMATION FOR SEQ ID NO: 1083: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 925 ammo acids

(B) TYPE: ammo acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(ill) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...925

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 1083 :

Leu Val He He Ser Leu Leu Thr Thr Leu Lys Leu Lys Ser He Lys

1 5 10 15

Glu He Ser He Lys Lys Phe He Leu Ser Ser Leu Val Phe Ala Cys

20 25 30

He Asn Thr Gly Val Glu Ala Leu Glu Asn Asp Gly Ser Lys Pro Asn

35 40 45

Asp Leu Ala Ser Pro Lys Glu Thr Pro Lys Glu Ala Gin Lys Asn Glu

50 55 60

Ala Gin Asn Glu Thr Ser Gin Ser Asn Gin Thr Pro Lys Glu Met Lys 65 70 75 80

Val Lys Ser He Ser Tyr Val Gly Leu Ser Tyr Met Ser Asp Met Leu

85 90 95

Ala Asn Glu He Ala Lys He Arg Val Gly Asp Met Val Asp Ser Lys

100 105 110

Lys He Asp Thr Ala Val Leu Ala Leu Phe Asn Gin Gly Tyr Phe Lys

115 120 125

Asp Val Tyr Ala Thr Phe Glu Asn Gly He Leu Glu Phe His Phe Asp

130 135 140

Glu Lys Ala Arg He Ala Gly Val Glu He Lys Gly Tyr Gly Thr Glu 145 150 155 160

Lys Glu Lys Asp Gly Leu Lys Ser Gin Met Gly He Lys Lys Gly Asp

165 170 175

Thr Phe Asp Glu Gin Lys Leu Glu His Ala Lys Thr Ala Leu Lys Thr

180 185 190

Ala Leu Glu Gly Gin Gly Tyr Tyr Gly Ser Val Val Glu Val Arg Thr

195 200 205

Glu Lys Val Ser Glu Gly Ala Leu Leu He Val Phe Asp Val Asn Arg

210 215 220

Gly Asp Ser He Tyr He Lys Gin Ser He Tyr Glu Gly Ser Asp Lys 225 230 235 240

Leu Lys Arg Arg Val He Glu Ser Leu Ser Ala Asn Lys Gin Arg Asp

245 250 255

Phe Met Gly Trp Met Trp Gly Leu Asn Asp Gly Lys Leu Arg Leu Asp

260 265 270

Gin Leu Glu Tyr Asp Ser Leu Arg He Gin Asp Val Tyr Met Arg Arg

275 280 285

Gly Tyr Leu Asp Ala His He Ser Ser Pro Phe Leu Lys Thr Asp Phe 290 295 300 Ser Thr His Asp Ala Lys Leu His Tyr Lys Val Lys Glu Gly He Gin 305 310 315 320

Tyr Arg He Ser Asp He Leu He Glu He Asp Asn Pro Val Val Pro

325 330 335

Leu Lys Thr Leu Glu Lys Ala Leu Lys Val Lys Arg Lys Asp Val Phe

340 345 350

Asn He Glu His Leu Arg Ala Asp Ala Gin He Leu Lys Thr Glu He

355 360 365

Ala Asp Lys Gly Tyr Ala Phe Ala Val Val Lys Pro Asp Leu Asp Lys

370 375 380

Asp Glu Lys Asn Gly Leu Val Lys Val He Tyr Arg He Glu Val Gly 385 390 395 400

Asp Met Val His He Asn Asp Val He He Ser Gly Asn Gin Arg Thr

405 410 415

Ser Asp Arg He He Arg Arg Glu Leu Leu Leu Gly Pro Lys Asp Lys

420 425 430

Tyr Asn Leu Thr Lys Leu Arg Asn Ser Glu Asn Ser Leu Arg Arg Leu

435 440 445

Gly Phe Phe Ser Lys Val Lys He Glu Glu Lys Arg Val Asn Ser Ser

450 455 460

Leu Met Asp Leu Leu Val Ser Val Glu Glu Gly Arg Thr Gly Gin Leu 465 470 475 480

Gin Phe Gly Leu Gly Tyr Gly Ser Tyr Gly Gly Leu Met Leu Asn Gly

485 490 495

Ser Val Ser Glu Arg Asn Leu Phe Gly Thr Gly Gin Ser Met Ser Leu

500 505 510

Tyr Ala Asn He Ala Thr Gly Gly Gly Arg Ser Tyr Pro Gly Met Pro

515 520 525

Lys Gly Ala Gly Arg Met Phe Ala Gly Asn Leu Ser Leu Thr Asn Pro

530 535 540

Arg He Phe Asp Ser Trp Tyr Ser Ser Thr He Asn Leu Tyr Ala Asp 545 550 555 560

Tyr Arg He Ser Tyr Gin Tyr He Gin Gin Gly Gly Gly Phe Gly Val

565 570 575

Asn Val Gly Arg Met Leu Gly Asn Arg Thr His Val Ser Leu Gly Tyr

580 585 590

Asn Leu Asn Val Thr Lys Leu Leu Gly Phe Ser Ser Pro Leu Tyr Asn

595 600 605

Arg Tyr Tyr Ser Ser Val Asn Glu Val Ala Ser Pro Arg Gin Cys Ser

610 615 620

Thr Pro Ala Ser Val He He Asn Arg Leu Ser Gly Gly Arg Thr Pro 625 630 635 640

Leu Val Pro Glu Ser Cys Ser Ser Pro Gly Ala He Thr Thr Ser Pro

645 650 655

Glu He Lys Gly He Trp Asp Arg Asp Tyr His Thr Pro He Thr Ser

660 665 670

Ser Phe Thr Leu Asp Val Ser Tyr Asp Asn Thr Asp Asp Tyr Tyr Phe

675 680 685

Pro Arg Asn Gly Val He Phe Ser Ser Tyr Ala Thr Met Ser Gly Leu

690 695 700

Pro Ser Ser Gly Thr Leu Asn Ser Trp Asn Gly Leu Gly Gly Asn Val 705 710 715 720

Arg Asn Thr Lys Val Tyr Gly Lys Phe Ala Ala Tyr His His Leu Gin

725 730 735

Lys Tyr Leu Leu He Asp Leu He Ala Arg Phe Lys Thr Gin Gly Gly

740 745 750

Tyr He Phe Arg Tyr Asn Thr Asp Asp Tyr Leu Pro Leu Asn Ser Thr 755 760 765

Phe Tyr Me Gly Gly Val Thr Thr Val Arg Gly Phe Arg Asn Gly Ser

770 775 780

He Thr Pro Lys Asp Glu Phe Gly Leu Trp Leu Gly Gly Asp Gly He 785 790 795 800

Phe Thr Ala Ser Thr Glu Leu Ser Tyr Gly Val Leu Lys Ala Ala Lys

805 810 815

Met Arg Leu Ala Trp Phe Phe Asp Phe Gly Phe Leu Thr Phe Lys Thr

820 825 830

Pro Thr Arg Gly Ser Phe Phe Tyr Asn Ala Pro Thr Thr Thr Ala Asn

835 840 845

Phe Lys Asp Tyr Gly Val Val Gly Ala Gly Phe Glu Arg Ala Thr Trp

850 855 860

Arg Ala Ser Thr Gly Leu Gin He Glu Trp He Ser Pro Met Gly Pro 865 870 875 880

Leu Val Leu He Phe Pro He Ala Phe Phe Asn Gin Trp Gly Asp Gly

885 890 895

Asn Gly Lys Lys Cys Lys Gly Leu Cys Phe Asn Pro Asn Met Asn Asp

900 905 910

Tyr Thr Gin His Phe Glu Phe Ser Met Gly Thr Arg Phe 915 920 925

(2) INFORMATION FOR SEQ ID NO: 1084:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 191 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 191

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 1084 :

Met Lys Gin Leu Phe Leu He He Gly Ala Pro Gly Ser Gly Lys Thr

1 5 10 15

Thr Asp Ala Glu Leu He Ala Lys Asn Asn Ser Glu Thr He Ala His

20 25 30

Phe Ser Thr Gly Asp Leu Leu Arg Ala Glu Ser Ala Lys Lys Thr Glu

35 40 45

Arg Gly Leu Leu He Glu Lys Phe Thr Ser Gin Gly Glu Leu Val Pro

50 55 60

Leu Glu He Val Val Glu Thr He Leu Ser Ala He Lys Ser Ser Ser 65 70 75 80

Lys Gly He He Leu He Asp Gly Tyr Pro Arg Ser Val Glu Gin Met

85 90 95

Gin Ala Leu Asp Lys Glu Leu Asn Ala Gin Asn Glu Val He Leu Lys

100 105 110

Ser Val He Glu Val Glu Val Ser Glu Asn Thr Ala Lys Glu Arg Val 115 120 125

Leu Gly Arg Ser Arg Gly Ala Asp Asp Asn Glu Arg Val Phe His Asn

130 135 140

Arg Met Arg Val Phe Leu Asp Pro Leu Val Glu He Gin Asn Phe Tyr 145 150 155 160

Lys Ala Lys His Leu His Lys He He Asn Gly Glu Arg Ser He Glu

165 170 175

Glu He Val Asn Glu Met Gin Lys Tyr He Leu Ser Phe Ala Asn 180 185 190

(2) INFORMATION FOR SEQ ID NO: 1085:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 340 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...340

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1085:

Leu Ser Ser Leu Trp Leu Thr Asn Pro Leu Asn Ala His Glu Lys Asn

1 5 10 15

Gly Ala Phe Val Gly He Ser Leu Glu Val Gly Arg Val Asp Gin Lys

20 25 30

Thr Asn Ala Tyr Arg Asn Gly Glu Leu Phe Gin Val Pro Phe Gly Asp

35 40 45

Val Ser Ala Asn Asp Asp Gly Lys Val Pro Asp Gly Gin Thr Gly Gly

50 55 60

Cys Gin Pro Ala Ser Gly Thr Pro Gly Thr Pro Gly Tyr Thr Lys Ala 65 70 75 80

Asn Cys Val Val Asn Trp Thr Ser Arg Thr Met Leu Ser Thr Asn Lys

85 90 95

Asp He Pro Gly Arg Asn Gin Pro Met Tyr Gly Leu Gly Val Met Thr

100 105 110

Gly Tyr Lys His Phe Val Gly Lys Lys Arg Trp Phe Gly Leu Arg Tyr

115 120 125

Tyr Gly Phe Phe Asp Tyr Gly His Thr Asn Phe Ser Asn Ser Arg Ala

130 135 140

Ala Asn Ala He Ser Pro Phe Tyr Leu Ser Asp Gin Lys Ala Asp Met 145 150 155 160

Tyr Thr Tyr Gly Phe Gly Thr Asp Met Leu Phe Asn Val He Asp Lys

165 170 175

Pro Lys Ala Thr Ala Gly Phe Phe Val Gly Val Asn Phe Ala Gly Asn

180 185 190

Thr Trp Thr Asn Asn Arg Val Gly Tyr Phe Lys Asp Gly Tyr Val Tyr

195 200 205

Gly Val Asn Thr Asp Ala Asp Ala Tyr Met Thr Asn Ala Asp Gly Thr 210 215 220

He Thr Cys Gly Asp Thr Thr Pro Ala Ser Cys Asn Val Gly He Asn 225 230 235 240

Pro Asn Ser Val Tyr Thr Thr Gly Lys Leu Asn Ala Lys Val Asn His

245 250 255

Thr He Phe Gin Phe Leu Val Asn Val Gly He Arg Thr Asn He Phe

260 265 270

Glu His His Gly He Glu Phe Gly He Lys He Pro Thr Leu Pro Asn

275 280 285

Tyr Phe Phe Lys Gly Ser Thr Thr He Arg Ala Lys Lys Gin Gly Pro

290 295 300

Leu Glu Asn Gly Asn Pro Thr Thr He Thr Gly Ala Glu Thr Asn Phe 305 310 315 320

Ser Leu Thr Gin Thr Leu Arg Arg Gin Tyr Ser Met Tyr Leu Arg Tyr

325 330 335

Val Tyr Thr Phe 340

(2) INFORMATION FOR SEQ ID NO: 1086:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 528 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 528

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1086:

Met Lys Leu Lys Lys Arg Lys Val Ala Ala Thr Leu Leu Lys Arg Leu

1 5 10 15

Thr Leu Pro Leu Leu Phe Thr Thr Gly Ser Leu Gly Ala Val Thr Tyr

20 25 30

Glu Val His Gly Asp Phe He Asn Phe Ser Lys Val Gly Phe Asn Arg

35 40 45

Ser Pro He Asn Pro Val Lys Gly He Tyr Pro Thr Glu Thr Phe Val

50 55 60

Asn Leu Thr Gly Lys Leu Glu Gly Ser Val His Leu Gly Arg Gly Trp 65 70 75 80

Thr Val Asn Val Gly Gly Val Leu Gly Gly Gin Val Tyr Asp Asn Thr

85 90 95

Arg Tyr Asp Arg Trp Ala Lys Asp Phe Thr Pro Pro Ser Tyr Trp Asp

100 105 110

Lys Thr Ser Cys Gly Thr Asp Ser Leu Ser Leu Cys Met Asn Ala Thr

115 120 125

Lys Met Trp Gin Gin Gin Gly Pro Gly Gly He He Asp Pro Arg Gly

130 135 140

He Gly Tyr Met Tyr Met Gly Glu Trp Asn Gly Leu Phe Pro Asn Tyr 145 150 155 160

Tyr Pro Ala Asn Ala Tyr Leu Pro Gly His Ser Arg Arg Tyr Glu Val

165 170 175

Tyr Lys Ala Asn Leu Thr Tyr Asp Ser Asp Arg Val His Met Val Met

180 185 190

Gly Arg Phe Asp Val Thr Glu Gin Glu Gin Met Asp Trp He Tyr Gin

195 200 205

Leu Phe Gin Gly Phe Tyr Gly Thr Phe Lys Leu Thr Lys Asn Met Lys

210 215 220

Phe Leu Leu Phe Ser Ser Trp Gly Arg Gly He Ala Asp Gly Gin Trp 225 230 235 240

Leu Phe Pro He Tyr Arg Glu Lys Pro Trp Gly He His Lys Ala Gly

245 250 255

He He Tyr Arg Pro Thr Lys Asn Leu Met He His Pro Tyr Val Tyr

260 265 270

Leu He Pro Met Val Gly Thr Leu Pro Gly Ala Lys He Glu Tyr Asp

275 280 285

Thr Asn Pro Glu Phe Ser Gly Arg Gly He Arg Asn Lys Thr Thr Phe

290 295 300

Tyr Val Leu Tyr Asp Tyr Arg Trp Asn Asn Ala Glu Tyr Gly Arg Tyr 305 310 315 320

Ala Pro Ala Arg Tyr Asn Thr Trp Asp Pro Phe Leu Asp Asn Gly Lys

325 330 335

Trp Arg Gly Leu Gin Gly Pro Gly Gly Ala Thr Leu Tyr Leu His His

340 345 350

His He Asp He Asn Asn Tyr Phe Val Val Gly Gly Ala Tyr Leu Asn

355 360 365

He Gly Asn Pro Asn Met Asn Leu Gly Thr Trp Gly Asn Pro Val Ala

370 375 380

Leu Asp Gly He Glu Gin Trp Val Gly Gly He Tyr Ser Leu Gly Phe 385 390 395 400

Ala Gly He Asp Asn He Thr Asp Ala Asp Ala Phe Thr Glu Tyr Val

405 410 415

Lys Gly Gly Gly Lys His Gly Lys Phe Ser Trp Ser Val Tyr Gin Arg

420 425 430

Phe Thr Thr Ala Pro Arg Ala Leu Glu Tyr Gly He Gly Met Tyr Leu

435 440 445

Asp Tyr Gin Phe Ser Lys His Val Lys Ala Gly Leu Lys Leu Val Trp

450 455 460

Leu Glu Phe Gin He Arg Ala Gly Tyr Asn Pro Gly Thr Gly Phe Leu 465 470 475 480

Gly Pro Asn Gly Gin Pro Leu Asn Leu Asn Asn Gly Leu Phe Glu Ser

485 490 495

Ser Ala Phe Ala Gin Gly Pro Gin Asn Met Gly Gly He Ala Lys Ser

500 505 510

He Thr Gin Asp Arg Ser His Leu Met Thr His He Ser Tyr Ser Phe 515 520 525

(2) INFORMATION FOR SEQ ID NO: 1087:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 234 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL : YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME/ KEY : mi scjeature

( B ) LOCATION 1 . . . 234

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 1087 :

Met Thr Lys He Ala Met Ala Asn Phe Lys Ser Ala Met Pro Val Phe

1 5 10 15

Lys Ser His Ala Tyr Leu Lys Glu Leu Glu Lys Thr Leu Lys Pro Gin

20 25 30

His Phe Asp Arg Val Phe Val Phe Pro Asp Phe Leu Gly Leu Leu Pro

35 40 45

Asn Ala Phe Leu His Phe Thr Leu Gly Ala Gin Asn Ala Tyr Pro Arg

50 55 60

Asp Cys Gly Ala Phe Thr Gly Glu He Thr Ser Lys His Leu Glu Glu 65 70 75 80

Leu Lys He His Thr Leu Leu He Gly His Ser Glu Arg Arg Val Leu

85 90 95

Leu Lys Glu Ser Pro Ser Phe Leu Lys Glu Lys Phe Asp Phe Phe Lys

100 105 110

Gly Lys Asn Phe Lys He Val Tyr Cys He Gly Glu Asp Leu Thr Thr

115 120 125

Arg Glu Lys Gly Phe Arg Ala Val Lys Glu Phe Leu Ser Glu Gin Leu

130 135 140

Glu Asn He Asp Leu Asn Tyr Ser Asn Leu He Val Ala Tyr Glu Pro 145 150 155 160

He Trp Ala He Gly Thr Lys Lys Ser Ala Ser Leu Glu Asp He Tyr

165 170 175

Leu Thr His Gly Phe Leu Lys Gin He Leu Asn Gin Lys Thr Pro Leu

180 185 190

Leu Tyr Gly Gly Ser Val Asn Ala Gin Asn Ala Lys Glu He Leu Gly

195 200 205

He Asp Ser Val Asp Gly Leu Leu He Gly Ser Ala Ser Leu Glu Leu

210 215 220

Glu Asn Phe Lys Thr He He Ser Phe Leu 225 230

(2) INFORMATION FOR SEQ ID NO: 1088:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 465 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL : YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE: ( A ) NAME / KEY : mi scjeature

( B ) LOCATION 1 . . . 465

( xi ) SEQUENCE DESCRI PTION : SEQ ID NO : 1088 :

Met Phe H e Tyr Asp Thr Lys Leu Lys Gin Lys Val Pro Phe Glu Pro

1 5 10 15

Leu Val His Asn Lys Ala Asn He Tyr Val Cys Gly Pro Thr Val Tyr

20 25 30

Asp Asp Ala His Leu Gly His Ala Arg Ser Ala He Ala Phe Asp Leu

35 40 45

Leu Arg Arg Thr Leu Glu Leu Ser Gly Tyr Glu Val Val Leu Val Arg

50 55 60

Asn Phe Thr Asp He Asp Asp Lys He He Asn Lys Ala Phe Lys Glu 65 70 75 80

Asn Lys Ser He Gin Glu Leu Ser Ser He Tyr He Glu Ser Tyr Thr

85 90 95

Arg Asp Leu Asn Ala Leu Asn Val Lys Gin Pro Ser Leu Glu Pro Lys

100 105 110

Ala Ser Glu Tyr Leu Asp Ala Met Val Arg Met He Glu Thr Leu Leu

115 120 125

Glu Lys Asn Phe Ala Tyr Arg Val Ser Asn Gly Asp He Tyr Leu Asp

130 135 140

Thr Ser Lys Asp Lys Asp Tyr Gly Ser Leu Ser Met His Asn Ser Ser 145 150 155 160

Val Glu Phe Ser Arg He Gly Leu Val Gin Glu Lys Arg Leu Glu Gin

165 170 175

Asp Phe Val Leu Trp Lys Ser Tyr Lys Gly Asp Asn Asp Val Gly Phe

180 185 190

Asp Ser Pro Leu Gly Lys Gly Arg Pro Gly Trp His He Glu Cys Ser

195 200 205

Ser Met Val Phe Glu Thr Leu Ala Leu Ala Asn Ala Pro Tyr Gin He

210 215 220

Asp He His Ala Gly Gly Thr Asp Leu Leu Phe Pro His His Glu Asn 225 230 235 240

Glu Ala Cys Gin Thr Arg Cys Ala Phe Gly Val Glu He Ala Lys Tyr

245 250 255

Trp Met His Asn Gly Phe Val Asn He Asn Asn Glu Lys Met Ser Lys

260 265 270

Ser Leu Gly Asn Ser Phe Phe He Lys Asp Ala Leu Lys Asn Tyr Asp

275 280 285

Gly Glu He Leu Arg Asn Tyr Leu Leu Gly Val His Tyr Arg Ser Val

290 295 300

Leu Asn Phe Asn Glu Glu Asp Leu Leu Met Ser Lys Lys Arg Leu Asp 305 310 315 320

Lys He Tyr Arg Leu Lys Gin Arg Val Leu Gly Thr Leu Gly Gly He

325 330 335

Asn Pro Asn Phe Lys Lys Glu He Leu Glu Cys Met Gin Asp Asp Leu

340 345 350

Asn Val Ser Lys Ala Leu Ser Val Leu Glu Ser Met Leu Ser Ser Thr

355 360 365

Asn Glu Lys Leu Asp Gin Asn Pro Lys Asn Lys Ala Leu Lys Gly Glu

370 375 380

He Leu Ala Asn Leu Lys Phe He Glu Glu Leu Leu Gly He Gly Phe 385 390 395 400

Lys Asp Pro Ser Ala Tyr Phe Gin Leu Gly Val Ser Glu Ser Glu Lys 405 410 415 Gin Glu He Glu Asn Lys He Glu Glu Arg Lys Arg Ala Lys Glu Gin

420 425 430

Lys Asp Phe Leu Lys Ala Asp Ser He Arg Glu Glu Leu Leu Gin Gin

435 440 445

Lys He Ala Leu Met Asp Thr Pro Gin Gly Thr He Trp Glu Lys Leu

450 455 460

Phe 465

(2) INFORMATION FOR SEQ ID NO: 1089:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1213 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...1213

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1089:

Met Lys Gin Phe Lys Lys Lys Pro Lys Lys He Lys Arg Ser His Gin

1 5 10 15

Asn Gin Lys Thr He Leu Lys Arg Pro Leu Trp Leu Met Pro Leu Leu

20 25 30

He Gly Gly Phe Ala Ser Gly Val Tyr Ala Asp Gly Thr Asp He Leu

35 40 45

Gly Leu Ser Trp Gly Glu Lys Ser Gin Lys Val Cys Val His Arg Pro

50 55 60

Trp Tyr Ala He Trp Ser Cys Asp Lys Trp Glu Glu Lys Thr Gin Gin 65 70 75 80

Phe Thr Gly Asn Gin Leu He Thr Lys Thr Trp Ala Gly Gly Asn Ala

85 90 95

Ala Asn Tyr Tyr His Ser Gin Asn Asn Gin Asp He Thr Ala Asn Leu

100 105 110

Lys Asn Asp Asn Gly Thr Tyr Phe Leu Ser Gly Leu Tyr Asn Tyr Thr

115 120 125

Gly Gly Glu Tyr Asn Gly Gly Asn Leu Asp He Glu Leu Gly Ser Asn

130 135 140

Ala Thr Phe Asn Leu Gly Ala Ser Ser Gly Asn Ser Phe Thr Ser Trp 145 150 155 160

Tyr Pro Asn Gly His Thr Asp Val Thr Phe Ser Ala Gly Thr He Asn

165 170 175

Val Asn Asn Ser Val Glu Val Gly Asn Arg Val Gly Ser Gly Ala Gly

180 185 190

Thr His Thr Gly Thr Ala Thr Leu Asn Leu Asn Ala Asn Lys Val Thr

195 200 205

He Asn Ser Asn He Ser Ala Tyr Lys Thr Ser Gin Val Asn Val Gly 210 215 220 Asn Ala Asn Ser Val He Thr He Asn Ser Val Ser Leu Asn Gly Asp 225 230 235 240

Thr Cys Ser Ser Leu Ala Arg Val Gly Val Gly Ala Asn Cys Ser Thr

245 250 255

Ser Gly Pro Ser Tyr Ser Phe Lys Gly Thr Thr Asn Ala Thr Asn Thr

260 265 270

Thr Phe Ser Asn Ser Ser Gly Ser Phe Thr Phe Glu Glu Asn Ala Thr

275 280 285

Phe Ser Gly Ala Lys Leu Asn Gly Gly Ala Phe Thr Phe Asn Lys Lys

290 295 300

Phe Asn Ala Thr Asn Asn Thr Ala Phe Asn Ser Gly Ser Phe Thr Phe 305 310 315 320

Lys Gly Thr Ser Ser Phe Asn Gly Ala Asn Phe Ser Asn Ala Ser Tyr

325 330 335

Thr Phe Asn Asn Gin Ala Thr Phe Gin Asn Ser Ser Phe Asn Gly Gly

340 345 350

Thr Phe Thr Phe Asn Asp Gin Thr Asn Gin Ser Thr Gin His Pro Gin

355 360 365

He Gin Asn Ser Ser Phe Ser Gly Ser Ala Thr Thr Leu Lys Gly Phe

370 375 380

Ala Thr Phe Glu Gin Ala Phe Asn Asn Ser Asn His Gin Leu Thr He 385 390 395 400

Gin Asn Ala Ser Phe Asn Asn Ala Thr Phe Asn Asn Thr Gly Lys He

405 410 415

Thr He Glu Lys Asp Ala Ser Phe Asn Asn Thr Ser Phe Asn Thr Pro

420 425 430

Val Asp Thr Asn Asn Met Thr He Ser Gly Gly Val Thr Leu Ser Gly

435 440 445

Lys Asn Asp Leu Lys Asn Gly Ala Thr Leu Asp Phe Gly Ser Ser Lys

450 455 460

He Thr Leu Thr Gin Gly Thr Thr Phe Asn Leu Thr Ser Leu Gly Ser 465 470 475 480

Glu Lys Ser Val Thr He Leu Asn Ser Arg Gly Gly He Thr Tyr Asn

485 490 495

His Leu Leu Asn His Ala He Asn Ser Leu Thr Asn Ala Leu Lys Thr

500 505 510

Asn Glu Ser Ser Ser Lys Pro Gin Ser Phe Ala Gin Gly Leu Trp Asp

515 520 525

Met He Thr Tyr Asn Gly Val Thr Gly Gin Leu Leu Asn Glu Asn Ala

530 535 540

Ala Thr Ser Lys Pro Thr Asp Ser Ser Pro Ser Lys Ser Ser Thr Asn 545 550 555 560

Ser Thr Gin Val Tyr Gin Val Gly Tyr Lys He Gly Asp Thr He Tyr

565 570 575

Lys Leu Gin Glu Thr Phe Ser His Asn Ser He He He Gin Ala Leu

580 585 590

Glu Ser Gly Thr Tyr Thr Pro Pro Pro Val He Asn Gly Ser Lys Phe

595 600 605

Asp Leu Ser Ala Ser Asn Tyr He Asn Ala Asp Met Pro Trp Tyr Asn

610 615 620

His Lys Tyr Tyr He Pro Lys Ser Gin Asn Phe Thr Glu Ser Gly Thr 625 630 635 640

Tyr Tyr Leu Pro Ser Val Gin He Trp Gly Ser Tyr Thr Asn Ser Phe

645 650 655

Lys Gin Thr Phe Ser Ala Ser Asn Ser Asn Leu Val He Gly Tyr Asn

660 665 670

Ala Thr Trp Thr Asp His Asn Val Ser Ser Ser Asp Thr Val Ala Phe 675 680 685

Gly Asp Thr Ser Gly Ser Ala Leu Asn Gly His Cys Gly Pro Trp Pro

690 695 700

Tyr Tyr Gin Cys Thr Gly Thr Thr Asn Gly Thr Tyr Ser Ala Tyr His 705 710 715 720

Val Tyr He Thr Ala Asn Leu Arg Ser Gly Asn Arg He Gly Thr Gly

725 730 735

Gly Ala Ala Asn Leu He Phe Asn Gly Val Asp Ser He Asn He Ala

740 745 750

Asn Ala Thr He Thr Gin His Asn Ala Gly Ala Tyr Ser Ser Ser Met

755 760 765

Thr Phe Ser Thr Gin Asn Met Asp Asn Ser Gin Asn Leu Asn Gly Leu

770 775 780

Asn Ser Asn Gly Lys Leu Leu Val Tyr Gly Thr Thr Phe Thr Asn Gin 785 790 795 800

Ala Lys Asp Gly Lys Phe He Phe Asn Ala Gly Gin Ala Thr Phe Glu

805 810 815

Asn Thr Asn Phe Asn Gly Gly Ser Tyr Gin Phe Ser Gly Asp Ser Leu

820 825 830

Asn Phe Ser Asn Asn Asn Gin Phe Asn Ser Gly Ser Phe Glu He Gly

835 840 845

Ala Lys Asn Thr He Phe Asn Asn Ala Asn Phe Asn Asn Ser Thr Ser

850 855 860

Phe Asn Phe Asn Asn Ser Ser Ala Thr Thr Ser Phe Val Gly Asp Phe 865 870 875 880

Thr Asn Ala Asn Ser Asn Leu Gin He Ala Gly Asn Ala Val Phe Gly

885 890 895

Asn Ser Thr Asn Gly Ser Gin Asn Thr Ala Asn Phe Asn Asn Thr Gly

900 905 910

Ser Val Asn He Ala Gly Asn Ala Thr Phe Asp Asn Val Val Phe Asn

915 920 925

Ser Pro Thr Asn Thr Ser Val Lys Gly Lys Val Thr Leu Asn Asn He

930 935 940

Thr Leu Lys Asn Leu Asn Ala Pro Leu Ser Phe Gly Asp Gly Thr He 945 950 955 960

Val Phe Ser Ala His Ser Val He Asn He Gly Glu Ala He Thr Asn

965 970 975

Gly Asn Pro He Thr Leu Val Ser Ser Ser Lys Ala He Glu Tyr Asn

980 985 990

Asp Ala Phe Ser Lys Asn Leu Trp Gin Leu He Asn Tyr Gin Gly His

995 1000 1005

Gly Ala Ser Ser Glu Lys Leu Val Ser Ser Ala Gly Asn Gly Val Tyr

1010 1015 1020

Asp Val Val Tyr Ser Phe Asn Asn Gin Thr Tyr Asn Phe Gin Glu Val 1025 1030 1035 1040

Phe Ser Pro Asn Ser He Ser He Arg Arg Leu Gly Val Gly Met Val

1045 1050 1055

Phe Asp Tyr Val Asp Met Glu Lys Ser Asp Arg Leu Tyr Tyr Gin Asn

1060 1065 1070

Ala Leu Gly Phe Met Thr Tyr Met Pro Asn Ser Tyr Asn Asn Asn Leu

1075 1080 1085

Gly Asn Leu Asn Asn Thr He Tyr Tyr Tyr Asp Asn Ser He Asp Phe

1090 1095 1100

Tyr Ala Ser Gly Lys Thr Leu Phe Thr Lys Ala Glu Phe Ser Gin Thr 1105 1110 1115 1120

Phe Thr Gly Gin Asn Ser Ala He Val Phe Gly Ala Lys Asn He Trp 1125 1130 1135 Thr Ser Val Ser Asp Ala Pro Gin Ser Asn Val He He Arg Phe Gly

1140 1145 1150

Asp Asn Lys Gly Ala Gly Ser Asn Asp Ala Ser Gly His Cys Trp Asn

1155 1160 1165

Leu Gin Cys He Gly Phe He Thr Gly His Tyr Glu Ala Gin Lys He

1170 1175 1180

Tyr He Thr Gly Ser He Glu Ser Gly Asn Arg He Ser Ser Gly Gly 1185 1190 1195 1200

Ala Arg Ala Leu He Leu Thr Gly Phe Lys Ala Phe Phe 1205 1210

(2) INFORMATION FOR SEQ ID NO: 1090:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 500 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...500

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1090:

Met Ala Glu Trp Lys Thr Asp Thr Glu Glu Val Lys Lys Val Val Gly

1 5 10 15

Arg Cys Arg Glu Phe Lys Arg Ser Leu Gin Glu Glu Lys Cys Ser Pro

20 25 30

Phe He Lys Asp Leu Asp Ser Tyr Ala Leu Lys He He Val Glu Arg

35 40 45

Arg Lys Thr Glu Met Gin Leu Glu Lys Ala He Gly Glu Leu Lys Lys

50 55 60

Ala Lys Ser Asn Glu Asp Asp Ala Lys Val Ala Leu Arg Val Leu Gin 65 70 75 80

Gly Ala Ser Val Val Ser Trp He Trp Pro Pro Ala Arg He Ala Ala

85 90 95

Thr Ala Ala He Val Ala Ala Glu Ala Val Leu Lys Phe Met Lys Glu

100 105 110

Asp Thr Glu Lys Cys Lys Arg Asn Val Glu Leu Leu Glu Arg Met Leu

115 120 125

Glu He Tyr Ser Asn Gin Ala Lys Ala Ser Ala Asn Leu Met Asn Gin

130 135 140

Ala Trp Glu Gly He Lys Lys Arg Leu His Phe Tyr Thr Asp Lys His 145 150 155 160

Gin Glu Phe He Arg Arg Leu Lys Gin Ala Ser Asp Ala He Asp Asn

165 170 175

Glu Tyr Asn Phe Pro Thr Pro Gly Val Leu Leu Glu Tyr Asp Phe Glu

180 185 190

Arg Pro Ala He Ser Tyr Thr Pro Lys Lys Ser Val Phe Asn Glu Arg 195 200 205 Leu Lys Asp Leu Arg Glu Asn Phe Ser Ala Ser Leu Tyr Ala Asp Leu

210 215 220

Lys Asp Lys He His His Asn Ala Leu Ser Asn Asp Asp Leu Glu Arg 225 230 235 240

Met He Ala Phe Arg Glu Gin Glu Phe Glu Lys Ser Leu Glu Asp Trp

245 250 255

Met Gly Ala Tyr Ser Tyr Asp Glu Asn Pro Asn Asp Glu Leu Asp Arg

260 265 270

Met Ala He Ser Lys Glu Gin Glu Leu Glu Lys Ser Leu Glu Asp Leu

275 280 285

Met Pro Ser Val Leu Gly Val Pro Ser Tyr Asn Glu Ser Leu Thr Leu

290 295 300

Ala Lys Asn Arg Cys Val Lys Asn Phe Lys Glu Ala Leu Glu Gly Phe 305 310 315 320

Thr Glu Lys He Lys Glu Ser Pro Asn Asp Ser Asn Ala He Asn Glu

325 330 335

Ala Phe Asp Asn Leu Glu Thr Glu Leu Glu Arg Ala Thr Glu Asn Leu

340 345 350

Ser Gin Lys He Asp Pro Val Leu Glu Arg Asn Glu Asn Tyr Thr Gin

355 360 365

Lys Ala Leu Glu Tyr Arg Glu Phe Leu Glu Ser Arg Lys Glu Ser Phe

370 375 380

He Val Asp Glu Lys Asn Pro Tyr Pro Glu Glu Val Ser Phe Asn Glu 385 390 395 400

Trp Arg Trp Ala Glu Phe Asp Ser Val Phe Ser Ala He Val Pro Leu

405 410 415

Glu Asp Leu Asn Lys Thr Ala Cys Ala His His Ala Leu Lys Ala Leu

420 425 430

Gin Ala Thr Leu Lys Asp Asn Asp Leu Gly Phe Asp Ala Thr Glu Leu

435 440 445

Glu Gin He Ala Lys Gly Phe He Pro Arg Gly Tyr Leu Trp His Phe

450 455 460

Asp Ala Asn Val Leu Gly Asn Leu Ala Leu Val Arg Glu Glu Leu Leu 465 470 475 480

Leu Gly Val Lys His Thr Lys Gly Tyr Ser Leu Trp Thr Glu Phe Leu

485 490 495

Gin Lys Gin Asn 500

(2) INFORMATION FOR SEQ ID NO: 1091:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE: (A) NAME/KEY: miscjeature

(B) LOCATION 1...22

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1091: TTAACCATGG TGAAAAGCGA TA 22

(2) INFORMATION FOR SEQ ID NO: 1092:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 23

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1092: TAGAATTCGC ATAACGATCA ATC 23

(2) INFORMATION FOR SEQ ID NO: 1093:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter, pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...22

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1093: TTAACCATGG TGAAAAGCGA TA 22 (2) INFORMATION FOR SEQ ID NO: 1094

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS. double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME / KEY : mi scjeature

( B ) LOCATION 1 . . . 23

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1094: TAGAATTCGC ATAACGATCA ATC 23

(2) INFORMATION FOR SEQ ID NO: 1095:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A) NAME / KEY : miscjeature

( B ) LOCATION 1 . . . 22

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1095: ATATCCATGG TGAGTTTGAT GA 22

(2) INFORMATION FOR SEQ ID NO: 1096:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular (n) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL. NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...25

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1096: ATGAATTCAA TTTTTTATTT TGCCA 25

(2) INFORMATION FOR SEQ ID NO: 1097:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...23

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1097: AATTCCATGG CTATCCAAAT CCG 23

(2) INFORMATION FOR SEQ ID NO: 1098:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (ill) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE

(A) ORGANISM Helicobacter pylori

(ix) FEATURE.

(A ) NAME / KEY . miscjeature

( B ) LOCATION 1 . . 25

(xi) SEQUENCE DESCRIPTION. SEQ ID NO.1098: ATGAATTCGC CAAAATCGTA GTATT 25

(2) INFORMATION FOR SEQ ID NO: 1099:

(l) SEQUENCE CHARACTERISTICS-

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A ) NAME/ KEY : mi scjeature

( B ) LOCATION 1 . . . 24

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO : 1099- GATACCATGG AATTTATGAA AAAG 24

(2) INFORMATION FOR SEQ ID NO: 1100:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...25 (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1100- TGAATTCGAA AAAGTGTAGT TATAC 25

(2) INFORMATION FOR SEQ ID NO: 1101:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...19

(xi) SEQUENCE DESCRIPTION: SEQ ID NO.1101: CCCTTCATTT TAGAAATCG 19

(2) INFORMATION FOR SEQ ID NO: 1102:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(lil) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1102: ATTTCAACCA ATTCAATGCG 20

(2) INFORMATION FOR SEQ ID NO: 1103: (l) SEQUENCE CHARACTERISTICS (A) LENGTH: 20 base pairs

(3) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1103: GCCCCTTTTG ATTTGAAGCT 20

(2) INFORMATION FOR SEQ ID NO: 1104:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME/ KEY : mi scjeature

( B ) LOCATION 1 . . . 22

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1104: TCGCTCCAAG ATACCAAGAA GT 22

(2) INFORMATION FOR SEQ ID NO: 1105:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...22

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1105: CTTGAATTAG GGGCAAAGAT CG 22

(2) INFORMATION FOR SEQ ID NO: 1106:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...22

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1106: ATGCGTTTTT ACCCAAAGAA GT 22

(2) INFORMATION FOR SEQ ID NO: 1107:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori (ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...22

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1107: ATAACGCCAC TTCCTTATTG GT 22

(2) INFORMATION FOR SEQ ID NO: 1108:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...19

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1108: CTTTGGGTAA AAACGCATC 19

(2) INFORMATION FOR SEQ ID NO: 1109:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1109: CGATCTTTGA TCCTAATTCA 20 (2) INFORMATION FOR SEQ ID NO: 1110:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...19

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1110: ATCAAGTTGC CTATGCTGA 19

(2) INFORMATION FOR SEQ ID NO: 1111:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...22

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1111: TTGAACACTT TTGATTATGC GG 22

(2) INFORMATION FOR SEQ ID NO: 1112:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double (D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 23

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1112: GGATTATGCG ATTGTTTTAC AAG 23

(2) INFORMATION FOR SEQ ID NO: 1113:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1113: GTCTTTAGCA AAAATGGCGT C 21

(2) INFORMATION FOR SEQ ID NO: 1114:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE-

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1114: AATGAGCGTA AGAGAGCCTT C 21

(2) INFORMATION FOR SEQ ID NO: 1115:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...18

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1115: CTTATGGGGG TATTGTCA 18

(2) INFORMATION FOR SEQ ID NO: 1116:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi ) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...18 (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1116: AGCATGTGGG TATCCAGC 18

(2) INFORMATION FOR SEQ ID NO: 1117:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...19

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1117: AGGTTGTTGC CTAAAGACT 19

(2) INFORMATION FOR SEQ ID NO: 1118:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL : NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 18

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1118: CTGCCTCCAC CTTTGATC 18

(2) INFORMATION FOR SEQ ID NO: 1119: (l) SEQUENCE CHARACTERISTICS: (A) LENGTH- 19 base pairs (3) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...19

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1119: ACCAATATCA ATTGGCACT 19

(2) INFORMATION FOR SEQ ID NO: 1120:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 18

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1120: ACTTGGAAAA GCTCTGCA 18

(2) INFORMATION FOR SEQ ID NO: 1121:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 19 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...19

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1121: CTTGCTTGTC ATATCTAGC 19

(2) INFORMATION FOR SEQ ID NO: 1122:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...18

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1122: GTTGAAGTGT TGGTGCTA 18

(2) INFORMATION FOR SEQ ID NO: 1123:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori (ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...22

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1123: CAAGCAAGTG GTTTGGTTTT AG 22

(2) INFORMATION FOR SEQ ID NO: 1124:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 22

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1124: TGGAAAGAGC AAATCATTGA AG 22

(2) INFORMATION FOR SEQ ID NO: 1125:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1125: GCCCATAATC AAAAAGCCCA T 21

(2) INFORMATION FOR SEQ ID NO: 1126:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 24

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1126: CTAAAACCAA ACCACTTGCT TGTC 24

(2) INFORMATION FOR SEQ ID NO: 1127:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 16

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1127: GTAAAACGAC GGCCAG 16

(2) INFORMATION FOR SEQ ID NO: 1128:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid (C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...17

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1128: CAGGAAACAG CTATGAC 17

(2) INFORMATION FOR SEQ ID NO: 1129:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1129: TTGCCCCATC GTATTGATAG A 21

(2) INFORMATION FOR SEQ ID NO: 1130:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1130: AGAGCGTATT TCACCCGAAA G 21

(2) INFORMATION FOR SEQ ID NO: 1131:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1131: TCTTGCATCT TAATCCACTC C 21

(2) INFORMATION FOR SEQ ID NO: 1132:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature (B) LOCATION 1...21 (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1132: CGGGTCAAAA CGACCACTTA A 21

(2) INFORMATION FOR SEQ ID NO:1133:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1133: AATCCGTTTC GCTAATTTAG T 21

(2) INFORMATION FOR SEQ ID NO: 1134:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1134: AACACTTCAA TTTCCTCTAT A 21

(2) INFORMATION FOR SEQ ID NO: 1135: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1135: TGGTATAAGG ATTTGAATGG A 21

(2) INFORMATION FOR SEQ ID NO: 1136:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1136: TTGACTAAAC ACATGCGAGA A 21

(2) INFORMATION FOR SEQ ID NO: 1137:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular (11) MOLECULE TYPE DNA (genomic)

(m) HYPOTHETICAL ^• NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM. Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1137: ATAGAGAGCG TTGTGTTTAG C 21

(2) INFORMATION FOR SEQ ID NO: 1138:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1138: CCTTTATTGG TTTTGATCGT G 21

(2) INFORMATION FOR SEQ ID NO: 1139:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE: ( A ) ORGANISM : Hel icobac ter pylori

( ix ) FEATURE :

(A ) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1139: ATGTCCGTTG TCTGTATGGA A 21

(2) INFORMATION FOR SEQ I'D NO: 1140:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1140: TAGGGTGTCT AGGGATTTGA T 21

(2) INFORMATION FOR SEQ ID NO: 1141:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1141: GCGTTTGGCT TCTTCGTTGT C 21

(2) INFORMATION FOR SEQ ID NO: 1142:

( ) SEQUENCE CHARACTERISTICS

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME / KEY : miscjeature

( B ) LOCATION 1 . . . 21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1142: GAAATGGAAA ATAGCGGTCA A 21

(2) INFORMATION FOR SEQ ID NO: 1143:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A ) NAME / KEY : miscjeature

( B ) LOCATION 1 . . . 20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1143:

GCAAATCCCC AGCCACTTCC 20

(2) INFORMATION FOR SEQ ID NO: 1144:

(l) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(11) MOLECULE TYPE- DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1144: GTGGCTAAAA ATGAGGGCTT 20

(2) INFORMATION FOR SEQ ID NO: 1145:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 22

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1145: GTTAGGAAAT TAGAAATCAT TG 22

(2) INFORMATION FOR SEQ ID NO: 1146:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic) (m) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO

(vi ) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE -

(A) NAME/KEY: miscjeature

(B) LOCATION 1...21

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 1146: GCTAAAACTT CATCGCTCAA T 21

(2) INFORMATION FOR SEQ ID NO: 1147:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(Vl) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...21

(Xl) SEQUENCE DESCRIPTION: SEQ ID NO: 1147: GTTGGGCAGA AAATAAGGTG A 21

(2) INFORMATION FOR SEQ ID NO: 1148:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(Vi ) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE: (A) NAME/KEY: miscjeature

(B) LOCATION 1...21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1148: CAAACAAACC TGACAAGAAA C 21

(2) INFORMATION FOR SEQ ID NO: 1149:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL : NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1149: CATTGATGCC TAAAACTTCG 20

(2) INFORMATION FOR SEQ ID NO: 1150:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1150: CGTGGTGGTT TTCCCGTTAG 20 (2) INFORMATION FOR SEQ ID NO 1151

(l) SEQUENCE CHARACTERISTICS

(A) LENGTH 20 base pairs

(B) TYPE- nucleic acid

(C) STRANDEDNESS. double

(D) TOPOLOGY circular

(n) MOLECULE TYPE- DNA (genomic)

(ill) HYPOTHETICAL- NO

(iv) ANTI-SENSE. NO

(vi) ORIGINAL SOURCE.

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY. miscjeature

(B) LOCATION 1...20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1151: GGGGCATTGT GTTTGTTTTT 20

(2) INFORMATION FOR SEQ ID NO: 1152:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1152- TGGTCTATCA TGCGAATTAT 20

(2) INFORMATION FOR SEQ ID NO: 1153:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY, circular (11) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE. NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM- Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1153: GCCCTGATCC ATTCCCCCCT 20

(2) INFORMATION FOR SEQ ID NO: 1154:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

( i) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL : NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...20

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 1154: CGCGCTAGAG GCTTGTAAAA 20

(2) INFORMATION FOR SEQ ID NO: 1155:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic) (ill) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1155: GCCCTGATCC ATTCCCCCCT 20

(2) INFORMATION FOR SEQ ID NO: 1156:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1156: CTGTTTTTAG CGTCCCTGTA 20

(2) INFORMATION FOR SEQ ID NO: 1157:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...20 (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1157: GGCGTTATTA AGCGACATCG 20

(2) INFORMATION FOR SEQ ID NO: 1158:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1158: TTTCACCGGC AATTTTAGGC 20

(2) INFORMATION FOR SEQ ID NO: 1159:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1159: GCGTTTTGAT TCTGTCTGTT A 21

(2) INFORMATION FOR SEQ ID NO: 1160: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS. double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL : NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1160: GTAAAAACAC CGCTAACGCA T 21

(2) INFORMATION FOR SEQ ID NO: 1161:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(lil) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1161: GCGTGTTTTC TAAGGGTTCA 20

(2) INFORMATION FOR SEQ ID NO: 1162:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic) (ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE.

(A) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1162: GGAATTTTAA CGCTCTTTTT 20

(2) INFORMATION FOR SEQ ID NO: 1163:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1163: AAATCTCTGT GGGCTTAGTG 20

(2) INFORMATION FOR SEQ ID NO: 1164:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi ) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori ( ix ) FEATURE .

(A) NAME/KEY. miscjeature

(B) LOCATION 1...20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1164: AATCAAAAAC AAGAGCGTGG 20

(2) INFORMATION FOR SEQ ID NO: 1165:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1165: GCCCCAGCCC CATAATACAA A 21

(2) INFORMATION FOR SEQ ID NO: 1166:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1166: GGAGGGCGCA ATTAAACATC G 21 (2) INFORMATION FOR SEQ ID NO: 1167:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH 20 base pairs

(B) TYPE, nucleic acid

(C) STRANDEDNESS- double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A ) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1167: TCACGCTTTC TAAATCATCA 20

(2) INFORMATION FOR SEQ ID NO: 1168:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1168: CGCTAATCAC ATCCTTTCTT 20

(2) INFORMATION FOR SEQ ID NO: 1169:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double (D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1169: TGCCCAAAAA TCCACTAACG 20

(2) INFORMATION FOR SEQ ID NO: 1170:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1170: AACGGGTTTG ACACTGATGA 20

(2) INFORMATION FOR SEQ ID NO: 1171:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1171: GAATGCGGTG GTTTTAGAGA G 21

(2) INFORMATION FOR SEQ ID NO: 1172:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1172: GCGTTTTTAA GACTGAATAC A 21

(2) INFORMATION FOR SEQ ID NO: 1173:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A ) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 20 (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1173: GGGCGATGTG ATTGGCGATT 20

(2) INFORMATION FOR SEQ ID NO: 1174:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1174: GGATAGCCTG CCAAAACGCC 20

(2) INFORMATION FOR SEQ ID NO: 1175:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1175: AAGTTTATGC GGGCGAGATT 20

(2) INFORMATION FOR SEQ ID NO: 1176: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL : NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1176: GGAGCAATCA GCCATTTTTC 20

(2) INFORMATION FOR SEQ ID NO: 1177:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

( B ) LOCATION 1...20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1177: CTAGCGATTC AAGGCGATGG 20

(2) INFORMATION FOR SEQ ID NO: 1178:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (ill) HYPOTHETICAL. NO

(iv) ANTI-SENSE NO

(vi) ORIGINAL SOURCE.

(A) ORGANISM. Helicobacter pylori

(ix) FEATURE:

( A) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1178: CGGCCTCCTT CAAACACATT 20

(2) INFORMATION FOR SEQ ID NO: 1179:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1179: AGCGGGCAGT TTAGGACCAC 20

(2) INFORMATION FOR SEQ ID NO: 1180:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori (ix) FEATURE -

(A) NAME/KEY miscjeature

(B) LOCATION 1...21

(xi) SEQUENCE DESCRIPTION. SEQ ID NO : 1180- GCATTGATCG CATTTTTAGC C 21

(2) INFORMATION FOR SEQ ID NO: 1181:

(l) SEQUENCE CHARACTERISTICS -

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1181: ACGGGTTAGC AGGGCAGAAT 20

(2) INFORMATION FOR SEQ ID NO: 1182:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1182: CAAAAGAGGC GGGTTCATGC 20

(2) INFORMATION FOR SEQ ID NO: 1183:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1183: TTTAGAAGTC GTTGATGAGA 20

(2) INFORMATION FOR SEQ ID NO: 1184:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1184: CATACACGCT CACTTCATCG 20

(2) INFORMATION FOR SEQ ID NO: 1185:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid (C) STRANDEDNESS double

(D) TOPOLOGY, circular

(11) MOLECULE TYPE. DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE- NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...22

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1185: AGTGTGGTCG CCTGTGGTGG AG 22

(2) INFORMATION FOR SEQ ID NO: 1186:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

( i) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...22

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1186: CCCCTAATAG TCTGTCAATC AT 22

(2) INFORMATION FOR SEQ ID NO: 1187:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (ill) HYPOTHETICAL: NO (iv) ANTI-SENSE. NO

(Vl ) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE-

( A ) NAME/ KEY : mi scjeature

( B ) LOCATION 1 . . . 22

(Xl ) SEQUENCE DESCRIPTION: SEQ ID NO: 1187: CAAAAGATTG AAGCAGAAGA GT 22

(2) INFORMATION FOR SEQ ID NO: 1188:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(Vi ) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 22

(Xl ) SEQUENCE DESCRIPTION: SEQ ID NO: 1188: AATGGTTTTC CTATACCCTT GA 22

(2) INFORMATION FOR SEQ ID NO: 1189:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(Vl) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature (B) LOCATION 1...20 (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1189: GAGAGCAAAT CCTTATCCAG 20

(2) INFORMATION FOR SEQ ID NO: 1190:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1190: CATACACGCT CACTTCATCG 20

(2) INFORMATION FOR SEQ ID NO: 1191:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...22

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1191: AGTGTGGTCG CCTGTGGTGG AG 22

(2) INFORMATION FOR SEQ ID NO: 1192: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY, circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...22

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1192: CCCCTAATAG TCTGTCAATC AT 22

(2) INFORMATION FOR SEQ ID NO: 1193:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 22

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1193: CAAAAGATTG AAGCAGAAGA GT 22

(2) INFORMATION FOR SEQ ID NO: 1194:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular (11) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE- NO

(v ) ORIGINAL SOURCE.

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...22

(Xl) SEQUENCE DESCRIPTION: SEQ ID NO: 1194: AATGGTTTTC CTATACCCTT GA 22

(2) INFORMATION FOR SEQ ID NO: 1195:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 21

(Xl) SEQUENCE DESCRIPTION: SEQ ID NO: 1195: TTGAAACCCC AAAAGTTTTA C 21

(2) INFORMATION FOR SEQ ID NO: 1196:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi ) ORIGINAL SOURCE: (A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY. miscjeature

(B) LOCATION 1...21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1196: TCAACTGATA GGTAATATCC C 21

(2) INFORMATION FOR SEQ ID NO: 1197:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1197: GCTAGGATTT ATGCCAATTT A 21

(2) INFORMATION FOR SEQ ID NO: 1198:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi ) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1198: TACGAGACAA AATAGGGATT T 21

(2) INFORMATION FOR SEQ ID NO: 1199:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1199: ATAGGCATGC AGAATTTTTC C 21

(2) INFORMATION FOR SEQ ID NO: 1200:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...17

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1200:

CCATTACATT TCGCCTC 17

(2) INFORMATION FOR SEQ ID NO: 1201:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(11) MOLECULE TYPE- DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1201. CGATAGATAT TGTAGAAGTC A 21

(2) INFORMATION FOR SEQ ID NO: 1202:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1202: GGGCTTGTAT TCATTTTGTA A 21

(2) INFORMATION FOR SEQ ID NO: 1203:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic) (m) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME / KEY : mi scjeature

( B ) LOCATION 1 . . . 21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1203: GTTTTAAAAA CGCCATAGCC A 21

(2) INFORMATION FOR SEQ ID NO: 1204:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1204: TTCTAAAAGG TGGTAATCTT C 21

(2) INFORMATION FOR SEQ ID NO: 1205:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE: (A) NAME/KEY- miscjeature

(B) LOCATION 1...22

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1205: TAAGTCAAGC CATAAAACCA AA 22

(2) INFORMATION FOR SEQ ID NO- 1206:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS. double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1206: TTTTGGGGTA AAAAGGCTGA A 21

(2) INFORMATION FOR SEQ ID NO: 1207:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi ) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1207: ATCTTTTTGC CCTTGCTCAT A 21 (2) INFORMATION FOR SEQ ID NO: 1208:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1208: AGACAGCACC AGTTTGATAA A 21

(2) INFORMATION FOR SEQ ID NO: 1209:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1209: CAGCCACACT TCAATGTCTA T 21

(2) INFORMATION FOR SEQ ID NO: 1210:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular (11) MOLECULE TYPE. DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE. NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1210: GTAAGGCGTT AGAAAAATAC C 21

(2) INFORMATION FOR SEQ ID NO: 1211:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1211: GCCCCATTAA AATCCTTTTC T 21

(2) INFORMATION FOR SEQ ID NO: 1212:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 17 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic) (ill) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi ) ORIGINAL SOURCE

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE-

(A) NAME/KEY- miscjeature

(B) LOCATION 1...17

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 1212: AAAGGATACA AGGGGGA 17

(2) INFORMATION FOR SEQ ID NO: 1213:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1213: CTCGCTCCAT TTTATCTTTT A 21

(2) INFORMATION FOR SEQ ID NO: 1214:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...21 (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1214: TTTTTTAGGG AGGATTGAGA T 21

(2) INFORMATION FOR SEQ ID NO: 1215:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature ^' (B) LOCATION 1...21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1215:

TGTTTGGAAA TGCTGGTGAT C 21

(2) INFORMATION FOR SEQ ID NO: 1216:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1216: CTTTTGGGGG AGTTTGACAA G 21

(2) INFORMATION FOR SEQ ID NO: 1217: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...21

(xi) SEQUENCE DESCRIPTION: SEQ -ID NO: 1217: TTTGATAAAC GCCCACTTTT T 21

(2) INFORMATION FOR SEQ ID NO: 1218:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1218: TTTCAAAACG CTCACCTTTT G 21

(2) INFORMATION FOR SEQ ID NO: 1219:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE. NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM. Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1219- TCTATTCTTT TGATGCTCTC T 21

(2) INFORMATION FOR SEQ ID NO: 1220:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(lil) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1220: ATAATGAGTT TGATCGTTAC G 21

(2) INFORMATION FOR SEQ ID NO: 1221:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori (ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...21

(xi) SEQUENCE DESCRIPTION- SEQ ID NO: 1221: ACAATAATAG GCTTTGTCTT C 21

(2) INFORMATION FOR SEQ ID NO: 1222.

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii] MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1222: AATTAGCCCT TAAAATAGAT G 21

(2) INFORMATION FOR SEQ ID NO: 1223:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A ) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1223: AACAACCGCT AAAATCAAAC 20 (2) INFORMATION FOR SEQ ID NO: 1224:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1224: CTTCAGCGAT ACTAAAAGAT 20

(2) INFORMATION FOR SEQ ID NO: 1225:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1225: TAGGGGCGAT TGAAAACAGC 20

(2) INFORMATION FOR SEQ ID NO: 1226:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double (D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1226: GCTGGATAAG GATTTGCTCT 20

(2) INFORMATION FOR SEQ ID NO: 1227:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1227: TTTTTGGGGG TATGCTAAAA 20

(2) INFORMATION FOR SEQ ID NO: 1228:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1228: GGCTGGTAAA TACTGGATAG 20

(2) INFORMATION FOR SEQ ID NO: 1229:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1229: AGGCTATTCA AGGTGGCTAA A 21

(2) INFORMATION FOR SEQ ID NO: 1230:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 22 (xi) SEQUENCE DESCRIPTION. SEQ ID NO 1230 ATTCTCATCA ACGACTTCTA AA 22

(2) INFORMATION FOR SEQ ID NO.1231.

(l) SEQUENCE CHARACTERISTICS.

(A) LENGTH. 20 base pairs

(B) TYPE, nucleic acid

(C) STRANDEDNESS. double

(D) TOPOLOGY- circular

(ii) MOLECULE TYPE. DNA (genomic)

(ill) HYPOTHETICAL. NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1231: GCAGTTGGCG GTATTTGGTG 20

(2) INFORMATION FOR SEQ ID NO: 1232:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1232: GAGAGCGAAG TTTATGAGAA 20

(2) INFORMATION FOR SEQ ID NO: 1233: (l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1233: TGATTGTTGG GTAGCTCTCA 20

(2) INFORMATION FOR SEQ ID NO: 1234:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1234: AAAATCGGTC TGATGCTCTT A 21

(2) INFORMATION FOR SEQ ID NO: 1235:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1235: CTTTTCCTTT CGCTTGAAGA 20

(2) INFORMATION FOR SEQ ID NO: 1236:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1236: AAAACAAACG CATCAAAAAT 20

(2) INFORMATION FOR SEQ ID NO: 1237:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori (ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1237: TTTCAAGGCG AGGAGGCAGA T 21

(2) INFORMATION FOR SEQ ID NO: 1238:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1238: GCACAAAGAC CCCACCACGA T 21

(2) INFORMATION FOR SEQ ID NO: 1239:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1239: CGCCCGAATG GATGAGTAGG 20

(2) INFORMATION FOR SEQ ID NO: 1240:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1240: TGCAACAAAA ATACGCCCTT 20

(2) INFORMATION FOR SEQ ID NO: 1241:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A ) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1241: TTTTTAAGGG CGTATTTTTG T 21

(2) INFORMATION FOR SEQ ID NO: 1242:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid (C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1242: TGGGTTTTAA GGAATGTGAT G 21

(2) INFORMATION FOR SEQ ID NO: 1243:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1243: CGCGCTCAAA ATCCCTAAAT 20

(2) INFORMATION FOR SEQ ID NO: 1244:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO ( iv ) ANTI - SENSE : NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME / KEY : mi scjeature

( B ) LOCATION 1 . . . 20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1244: GGCCCATTCT TTCGGATATT 20

(2) INFORMATION FOR SEQ ID NO: 1245:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1245: GCCCCATTCC TGTTTTTAGC 20

(2) INFORMATION FOR SEQ ID NO: 1246:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature (B) LOCATION 1...20 (xi) SEQUENCE DESCRIPTION. SEQ ID NO.1246: CGCTTTAACG CTCCTTTCAC 20

(2) INFORMATION FOR SEQ ID NO: 1247:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1247: AGCGTTTTTG TAAGGGGGTA T 21

(2) INFORMATION FOR SEQ ID NO: 1248:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi ) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1248: TCCCTATCAT AGCGTTAGTG C 21

(2) INFORMATION FOR SEQ ID NO: 1249: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1249: CTTAGGGGTT TTTAGCATGA A 21

(2) INFORMATION FOR SEQ ID NO: 1250:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1250: GCACAATTCC CACACGCTGC 20

(2) INFORMATION FOR SEQ ID NO: 1251:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1251: CCAAAGCTAA AGCGGTGTTT T 21

(2) INFORMATION FOR SEQ ID NO: 1252:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 23

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1252: GCTCATGGAT ATAAAGGGGT ATT 23

(2) INFORMATION FOR SEQ ID NO: 1253:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE: (A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1253: CTTAGCCCCT TTAGTGTTTA 20

(2) INFORMATION FOR SEQ ID NO: 1254:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1254: CGCAAAAGGG TAGGGGATAA 20

(2) INFORMATION FOR SEQ ID NO: 1255:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1255: TTTTATTTTT AGAAACGAAT C 21

(2) INFORMATION FOR SEQ ID NO: 1256:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1256: CAAACTTATC GCCCTCTCTA 20

(2) INFORMATION FOR SEQ ID NO: 1257:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...23

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1257:

AAAGATAACG CTAGGATTTC TAC 23

(2) INFORMATION FOR SEQ ID NO: 1258:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...23

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1258: TAATTCTACA GAGTGGTTAA TGG 23

(2) INFORMATION FOR SEQ ID NO: 1259:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1259: GCGGTCATGG AATTTTTAGA 20

(2) INFORMATION FOR SEQ ID NO: 1260:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE. NO

(vi) ORIGINAL SOURCE

(A) ORGANISM- Helicobacter pylori

(ix) FEATURE.

(A) NAME/KEY: miscjeature

(B) LOCATION 1...22

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1260: ATTCAAAGAA AGCTGGCTGT CT 22

(2) INFORMATION FOR SEQ ID NO: 1261:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(i ) MOLECULE TYPE: DNA (genomic)

(lil) HYPOTHETICAL: NO

(iv) ANTI-SENSE- NO

(Vl) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1261: GCTTGTGGGG GTTGTTTTAT 20

(2) INFORMATION FOR SEQ ID NO: 1262:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM- Helicobacter pylori

(ix) FEATURE: ( A ) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1262: GAACCCCCTA AAATGACAAT 20

(2) INFORMATION FOR SEQ ID NO: 1263:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1263: ACCATGCTCA TTAACGCTAG G 21

(2) INFORMATION FOR SEQ ID NO: 1264:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1264: GTAAGTTTGA GCGGCTAATT C 21 (2) INFORMATION FOR SEQ ID NO: 1265:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (3) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1265: AAAAAGAAAG AAGAACTCGT G 21

(2) INFORMATION FOR SEQ ID NO: 1266:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1266: AAAGATACTC CCCTGTGATT A 21

(2) INFORMATION FOR SEQ ID NO: 1267:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1267: CAAAGAAACG CAAAATACAG 20

(2) INFORMATION FOR SEQ ID NO: 1268:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/ KEY : miscjeature

( B) LOCATION 1 . . . 20

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1268: GCATGGTATT CAGCGTTTTC 20

(2) INFORMATION FOR SEQ ID NO: 1269:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (v ) ORIGINAL SOURCE.

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE-

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 21

(xi) SEQUENCE DESCRIPTION- SEQ ID NO: 1269: GCAGCGGCAC AGCGACTTTA G 21

(2) INFORMATION FOR SEQ ID NO: 1270:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1270: CGCCCCCAAA AAGTCGCAGT A 21

(2) INFORMATION FOR SEQ ID NO: 1271:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...22 (xi) SEQUENCE DESCRIPTION SEQ ID NO 1271

AAAGGTTTGA AACAAGAAAT CT 22

(2) INFORMATION FOR SEQ ID NO 1272:

(l) SEQUENCE CHARACTERISTICS. (A) LENGTH: 21 base pairs (3) TYPE nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY circular

( i) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1272: CACTTGAGCG TTAGCAACAA T 21

(2) INFORMATION FOR SEQ ID NO: 1273:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE.

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1273: GGGGTGTTTG AAATTGATAG A 21

(2) INFORMATION FOR SEQ ID NO: 1274: (l) SEQUENCE CHARACTERISTICS: (A) LENGTH 21 base pairs

(B) TYPE nucleic acid

(C) STRANDEDNESS. double

(D) TOPOLOGY, circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM. Helicobacter pylori

(ix) FEATURE:

(A ) NAME/KEY : mi scjeature

( B ) LOCATION 1 . . . 21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1274: CGCTAGGAGA AAGGAAGGAA A 21

(2) INFORMATION FOR SEQ ID NO: 1275:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(lil) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi ) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME / KEY : mi scjeature

( B ) LOCATION 1 . . . 21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1275: CAAGGGCGTT TTTTGGGGTA T 21

(2) INFORMATION FOR SEQ ID NO: 1276:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME/ KEY : mi scjeature

( B ) LOCATION 1 . . . 21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1276: GGGATTGTTA CAGGAAAAGA T 21

(2) INFORMATION FOR SEQ ID NO: 1277:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A ) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1277: GGAATACAAT AACGCATAAA T 21

(2) INFORMATION FOR SEQ ID NO:1278:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori (ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1278: GCCTTTTTAG ACAACCCTAC T 21

(2) INFORMATION FOR SEQ ID NO: 1279:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI -SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1279: CCCCTAAACT CAAATCTCAA T 21

(2) INFORMATION FOR SEQ ID NO: 1280:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1280: GCTAGAAATG CCATGAGAAA G 21 (2) INFORMATION FOR SEQ ID NO: 1281.

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1281: GCGATTATGG GGTATTTATT G 21

(2) INFORMATION FOR SEQ ID NO: 1282:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...21

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 1282: TTATTGTGGA GTTGCTTGTC A 21

(2) INFORMATION FOR SEQ ID NO: 1283:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double (D) TOPOLOGY circular

(11) MOLECULE TYPE. DNA (genomic)

(m) HYPOTHETICAL. NO

(iv) ANTI-SENSE- NO

(vi) ORIGINAL SOURCE.

(A) ORGANISM- Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1283- TATGCGGCTC ATCCTATTAA A 21

(2) INFORMATION FOR SEQ ID NO: 1284:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1284: CCCTAAATCC AAATCAAGCA G 21

(2) INFORMATION FOR SEQ ID NO: 1285:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(n) MOLECULE TYPE: DNA (genomic) (ill) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1285: ATCTTACCTA TCACCTCAAA T 21

(2) INFORMATION FOR SEQ ID NO: 1286:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 21

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1286: AGACAGCAAC ATCTTTGTGA A 21

(2) INFORMATION FOR SEQ ID NO: 1287:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...25 (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1287: TTATGGATCC AAACCAATTA AAACT 25

(2) INFORMATION FOR SEQ ID NO: 1288:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...23

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1288: TATCTCGAGT TATAGAGAAG GGC 23

(2) INFORMATION FOR SEQ ID NO: 1289:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 29 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 29

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1289: AAATAGTCAT ATGAAAATAG GCGTTTTTG 29

(2) INFORMATION FOR SEQ ID NO: 1290: (l) SEQUENCE CHARACTERISTICS.

(A) LENGTH. 28 base pairs

(B) TYPE nucleic acid

(C) STRANDEDNESS double

(D) TOPOLOGY, circular

(ii) MOLECULE TYPE: DNA (genomic)

(m) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM- Helicobacter pylori

(ix) FEATURE:

( A ) NAME / KEY : mi scjeature

( B ) LOCATION 1 . . . 28

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1290: AGAATTCTAT TACAATTTGA GCCATTCT 28

(2) INFORMATION FOR SEQ ID NO: 1291:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

( A ) NAME/ KEY : miscjeature

( B ) LOCATION 1 . . . 26

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1291: GCGAATTCGA TCAGAATTTT TTTTCT 26

(2) INFORMATION FOR SEQ ID NO: 1292:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic) (ill) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

( i) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...26

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 1292: ATAAGTACTT GTGAATCTTA TACTAG 26

(2) INFORMATION FOR SEQ ID NO: 1293:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2694 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

( iv) ANTI-SENSE : NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...2694

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1293:

ATGGAGCAGC CAGTCATTAA AGAAGGGACT TTAGCTTTAA TTGATACCTT TGCGTATTTG 60

TTTAGAAGCT ATTACATGAG CGCTAAAAAT AAGCCTTTAA CCAACGATAA GGGCTTTCCT 120

ACAGGGCTTT TAACGGGGCT TGTGGGCATG GTTAAAAAAT TTTATAAAGA CAGAAAAAAC 180

ATGCCTTTTA TCGTGTTCGC CCTAGAAAGC CAGACTAAAA CTAAAAGAGC TGAAAAACTG 240

GGCGAATACA AACAAAATCG TAAAGACGCC CCTAAAGAGA TGCTTTTACA AATCCCTATC 300

GCCTTAGAAT GGTTGCAAAA AATGGGTTTT ACTTGCGTGG AGGTGGGAGG GTTTGAAGCC 360

GATGATGTGA TCGCAAGTTT AGCCACGCTA AGCCCTTATA AAACCCGCAT TTATTCTAAA 420

GATAAGGATT TTAACCAGCT TTTGAGCGAT AAAATCGCGC TTTTTGATGG CAAAACGGAG 480

TTTTTGGCGA AAGATTGCGT GGAAAAATAC GGGATTTTGC CGAGTCAATT CACGGATTAT 540

CAGGGCATTG TGGGGGATAG CAGCGATAAT TACAAGGGGG TTAAAGGCAT TGGGAGCAAG 600

AACGCTAAGG AATTGTTGCA GCGATTAGGG AGCTTGGAAA AAATCTATGA AAATTTAGAC 660

TTGGCGAAAA ATTTACTCAG CCCTAAAATG TATCAAGCCT TGATACAAGA CAAAGGAAGC 720

GCCTTTTTAA GCAAAGAATT AGCCACTTTA GAAAGAGGAT GCATTAAAGA ATTTGATTTT 780

TTAAGTTGCG CTTTTCCGAG CGAAAACCCC TTGTTGAAAA TCAAAGATGA ATTGAAAGAA 840

TATGGTTTCA TTTCTACCTT AAGGGATTTA GAAAATTCCC CTTTCATTGT AGAAAACGTG 900

CCCATATTAA ACAGCACGCC TATATTAGAC AATACCCCCG CCTTAGACAA CGCCCCTAAA 960

AAATCGCGCA TGATTGTTTT AGAAAGCGCT GAGCCTTTGA GCATGTTTTT AGAAAAATTA 1020

GAAAACCCTA ACGCTAGGGT TTTTATGCGT TTGGTTTTGG ATAAAGACAA AAAAATTCTA 1080 GCCCTAGCGT TTTTATTACA AGATCAAGGC TATTTTTTAC CTTTAGAAGA GGCGTTGTTT 1140

TCGCCCTTTT CTTTGGAATT TTTACAAAAC GCTTTTTCTC AAATGTTACA GCATGCGTGT 1200

ATCATTGGGC ATGATTTAAA GCCTTTATTA AGCTTTTTAA AAGCCAAATA TCAGGTGCCT 1260

TTGGAAAATA TCCGCATCCA AGACACTCAG ATTTTAGCGT TTTTAAAGAA TCCGGAAAAA 1320

GTGGGGTTTG ATGAGGTTTT AAAGGAATAT TTAAAAGAAG ATTTAATCCC GCATGAAAAG 1380

ATCAAAGATT TTAAGACAAA AAGTAAGGCG GAAAAATCAG AACTTTTAAG CATGGAATTA 1440

AACGCCTTAA AGCGTTTGTG CGAATACTTT GAAAAAGGGG GGCTAGAAGA GGATTTGCTC 1500

ACTTTAGCTA GAGACATTGA AACGCCGTTT GTGAAAGTTT TAATGGGCAT GGAATTTCAA 1560

GGCTTTAAGA TTGATGCGCC TTATTTCAAG CGCTTAGAGC AGGAGTTTAA GAATGAATTA 1620

AACGTTTTAG AGCGCCAAAT TTTGGATCTA ATCGGCGTGG ATTTCAACCT CAATTCGCCC 1680

AAGCAACTTG GCGAAGTCTT GTATGATAAA TTAGGGCTTC CTAAAAATAA AAGCCACTCT 1740

ACCGATGAAA AAAACTTGTT AAAAATCCTA GACAAGCACC CAAGCATCCC TTTGATTTTA 1800

GAATACAGGG AATTGAATAA GCTTTTTAAC ACTTACACGA CCCCCTTATT GCGCTTAAAA 1860

GACAAAGACG ATAAAATCCA TACCACTTTC ATCCAAACCG GCACAGCTAC CGGGCGTTTA 1920

AGCTCGCATT CGCCTAATTT GCAAAATATC CCGGTGCGAT CGCCTAAAGG CTTACTCATT 1980

CGTAAGGGTT TTATCGCTAG CTCTAAAGAA TATTGTTTAT TAGGGGTGGA TTATTCGCAG 2040

ATTGAATTAC GCTTGTTGGC CCATTTCAGC CAGGATAAGG ATTTAATGGA AGCGTTTTTA 2100

AAGGGGCGAG ACATCCATTT AGAAACTTCT AAGGCGTTGT TTGGAGAAGA TTTAGCCAAA 2160

GAAAAACGAT CCATCGCTAA AAGCATTAAT TTTGGGCTGG TGTATGGCAT GGGGAGTAAG 2220

AAATTGAGCG AAACTTTAAG CATCCCTTTA AGTGAGGCTA AAAGTTACAT AGAAGCGTAT 2280

TTCAAGCGAT TCCCTAGCAT TAAAGATTAT TTGAATGGCA TGCGAGAAGA GATTTTAAAA 2340

ACTTCTAAAG CTTTTACTTT GCTGGGGCGT TACCGGGTGT TTGATTTTAC CGGCGTGAAT 2400

GATTATGTCA AGGGCAATTA TTTGCGAGAG GGCGTGAATG CGATTTTTCA AGGGAGTGCC 2460

AGCGATTTAT TGAAATTAGG CATGCTTAAA GTGAGCGAGC GTTTCAAAAA CAACCCTTCG 2520

GTGAGGCTGC TTTTGCAAGT GCATGACGAA TTGATTTTTG AAATTGAAGA AAAAAACGCC 2580

CCAGAGTTGC AGCAAGAAAT CCAACGCATT CTTAATGATG AAGTCTATCC TTTGAGGGTG 2640

CCGTTAGAAA CAAGCGCGTT TATCGCTAAG CGTTGGAATG AATTAAAAGG TTAG 2694

(2) INFORMATION FOR SEQ ID NO: 1294:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2007 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...2007

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1294:

ATGAAAAAAC CCTTTTACTC TCTCTCTCTC GCTTCATCGC TTTTAAACGC TGAAGACAAC 60

GGCTTTTTTA TCAGCGCGGG CTATCAAATC GGTGAAGCCG CTCAAATGGT GAAAAACACC 120

GGCGAATTGA AAAAACTTTC AGACACTTAT GAGAATTTGA GCAACCTTTT AACCAATTTT 180

AACAACCTCA ATCAGGCGGT AACGAACGCG AGCAGCCCTT CAGAAATCAA TGCTGCGATC 240

GATAATTTAA AAGCAAACAC GCAAGGGCTA ATTGGCGAAA AAACCAATTC CCCGGCGTAT 300

CAAGCGGTGT ATTTGGCGCT CAATGCGGCG GTAGGGCTGT GGAATGTCAT CGCCTATAAT 360 GTCCAATGCG GTCCTGGTAA CAGTGGACAA CAAAGCGTAA CCTTTGAGGG CCAACCAGGA 420

CATAATTCAA GTTCCATTAA TTGCAATTTA ACCGGTTATA ACAACGGGGT TAGCGGCCCT 480

TTATCCATTG AGAATTTTAA AAAGCTTAAT CAGGCTTATC AAACTATCCA ACAAGCTTTA 540

AAACAAGATA GCGGATTTCC TGTTTTGGAT AGTGCAGGAA AACAAGTAAC TATAACAATA 600

ACAACGCAAA CTAATGGAGC TAATAAAAGT GAAACTACTA CTACTACTAC TACTACTAAT 660

GACGCTCAAA CCCTTTTGCA AGAAGCCAGT AAAATGATAA GCGTCCTCAC TACAAACTGC 720

CCATGGGTCA ATCACAATCA AGGACAAAAC GGGGGCGCGC CGTGGGGTTT AGATACGGCA 780

GGGAATGTGT GTCAGGTTTT TGCCACGGAA TTTAGCGCCG TTACTAGCAT GATCAAAAAC 840

GCCCAAGAAA TCGTAACGCA AGCTCAAAGC CTTAACCAGC AAAACAATCA AAACGCGCCG 900

CAAGATTTCA ATCCTTACAC CTCTGCTGAT AGGGCTTTCG CTCAAAACAT GCTCAATCAC 960

GCGCAAGCGC AAGCCAAGAT ACTTGAGCTA GCCGATCAAA TGAAAAAAGA CCTTAACACT 1020

ATCCCAAGCC AATTTATCAC AAATTACTTG GCAGCTTGCC ACAATGGGGG TGGGACATTA 1080

CCTGATGCGG GGGTTACTAA CAACACTTGG GGGGCCGGTT GCGCGTATGT GGAAGAGACG 1140

ATAACGGCTT TAAACAACAG CCTTGCGCAT TTTGGCACTC AAGCTGAGCA AATCAAGCAA 1200

TCTGAGTTGT TGGCGCGCAC CATACTTGAT TTTAGAGGCA GCCTTAGTAA TTTAAACAAC 1260

ACTTATAACA GCATCACCAC GACCGCTTCA AACACGCCTA ATTCCCCATT CCTTAAAAAT 1320

TTGATAAGCC AATCCACTAA CCCTAATAAC CCCGGGGGCT TACAGGCCGT TTATCAAGTC 1380

AACCAAAGCG CTTATTCGCA ATTATTAAGC GCCACGCAAG AATTAGGGCA TAACCCTTTC 1440

AGACGCGTTG GATTAATCAG CTCTCAAACC AACAATGGTG CCATGAATGG GATCGGTGTG 1500

CAAGTGGGCT ACAAACAATT TTTTGGTGAA AAGAGAAGGT GGGGGTTAAG GTATTACGGC 1560

TTTTTTGACT ATAACCATGC TTATATCAAA TCTAGCTTTT TCAATTCGGC TTCTGATGTG 1620

TTCACTTATG GGGTAGGGAC AGATGTCCTC TATAACTTTA TCAATGATAA AACCACCAAA 1680

AACAGCAAGA TTTCTTTTGG GGTGTTTGGG GGGATTGCGT TAGCTGGCAC TTCATGGCTG 1740

AATTCCCAGT ATGTGAATTT AGCGACCTTC AATAATTTCT ATAGCGCTAA AATGAATGTG 1800

GCGAATTTCC AATTCTTGTT CAATTTAGGC TTGAGAATGA ACCTCGCTAA GAATAAGAAA 1860

AAAGCGAGCG ATCATGCGGC TCAGCATGGC GTGGAATTAG GCGTGAAGAT CCCCACGATC 1920

AACACGAATT ACTATTCTTT GCTAGGCACT CAACTCCAAT ACCGAAGATT GTATAGCGTG 1980

TATTTGAATT ATGTGTTCGC TTACTAA 2007

(2) INFORMATION FOR SEQ ID NO: 1295:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1914 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: circular

(ii) MOLECULE TYPE: DNA (genomic)

(iii) HYPOTHETICAL: NO

(iv) ANTI-SENSE: NO

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...1914

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1295:

ATGAAAAGAC AATTCTACTC TCTCTCTCTC TCTCTCGCTT CATCGCTCTT GCATGCTGAA 60

GACAACGGCT TTTTTGTGAG CGCGGGCTAT CAAATCGGCG AAGCGGTGCA AATGGTCAAA 120

AACACCGGCG AATTGAAAAA CTTGAACGAC AAATACGAGC AGTTAAGCCA ATCTTTAGCC 180

CAACTGGCTT CGTTAAAAAA AAGCATTCAA ACGGCGAACA ACATTCAGGC TGTCAACAAT 240

GCTTTAAGCG ATTTAAAAAG CTTTGCGAGT AACAACCACA CAAACAAAGA AACATCGCCC 300 ATCTACAACA CCGCGCAAGC TGTTATCACT TCAGTATTGG CTTTTTGGAG TCTTTATGCA 360

GGGAACGCTC TCAGTTTTCA TGTGACCGGT TTGAATGATG GATCTAATTC TCCTTTAGGA 420

AGAATCCATA GAGATGGGAA CTGCACAGGA TTACAACAAT GTTTTATGAG CAAAGAAACT 480

TATGATAAAA TGAAGACACT TGCCGAAAAC CTCCAAAAAG CTCAAGGCAA TCTCTGTGCC 540

TTATCAGAAT GCTCTAGCAA TCAATCAAAT GGAGGCAAAA CTTCCATGAC TACAGCTCTT 600

CAAACCGCGC AACAGCTCAT GGACTTAATC GAACAGACCA AGGTTTCTAT GGTGTGGAAA 660

AATATCGTCA TCGCAGGTGT TACAAACAAA CCCAATGGTG CTGGCGCTAT CACATCCACT 720

GGTCATGTAA CCGACTATGC GGTGTTTAAC AACATCAAGG CGATGCTACC TATCTTGCAA 780

CAAGCGCTTA CGCTTTCTCA AAGTAACCAC ACCCTATCCA CTCAGTTGCA AGCTCGAGCT 840

ATGGGATCTC AAACAAATCG TGAATTCGCT AAAGACATCT ACGCTTTAGC TCAAAACCAA 900

AAGCAAATCC TTTCTAACGC TTCAAGTATC TTCAATCTCT TTAATTCCAT TCCTAAAGAC 960

CAACTTAAGT ATTTGGAGAA CGCTTACTTG AAAGTGCCAC ATTTGGGTAA AACCCCTACT 1020

AACCCTTACA GACAGAATGT GAATTTGAAT AAAGAAATTA ATGCGGTTCA AGACAATGTA 1080

GCTAATTATG GTAATCGTTT GGATTCGGCT TTAAGCGTGG CTAAAGATGT TTATAACCTA 1140

AAATCCAATC AAACAGAGAT CGTAACCACT TATAACGATG CTAAGAATTT GAGCGAAGAG 1200

ATTTCTAAAC TTCCCTATAA CCAAGTCAAT GTAACAAACA TCGTTATGTC GCCTAAAGAT 1260

TCTACAGCGG GCCAATACCA AATCAACCCA GAGCAGCAAT CCAATCTTAA CCAAGCTTTA 1320

GCGGCGATGA GCAATAACCC CTTTAAAAAA GTGGGCATGA TCAGCTCTCA AAACAATAAC 1380

GGCGCTTTGA ACGGGCTTGG CGTGCAAGTG GGTTATAAAC AATTCTTTGG CGAAAGCAAA 1440

AGATGGGGGT TAAGGTATTA TGGTTTCTTT GATTACAACC ACGGCTATAT CAAATCCAGC 1500

TTTTTTAATT CTTCTTCTGA TATATGGACT TATGGCGGTG GGAGCGATTT GTTAGTGAAT 1560

TTTATCAACG ATAGCATCAC AAGAAAGAAC AACAAGCTTT CTGTGGGTCT TTTTGGTGGT 1620

ATCCAACTAG CAGGGACTAC ATGGCTTAAT TCTCAATACA TGAATTTAAC AGCGTTCAAT 1680

AACCCTTACA GCGCGAAAGT CAATGCTTCC AATTTCCAAT TTTTGTTCAA TCTCGGCTTG 1740

AGGACGAATC TCGCTACAGC TAAGAAAAAA GACAGCGAAC GTTCCGCGCA ACATGGCGTT 1800

GAACTGGGCA TTAAAATCCC TACCATTAAC ACCAATTATT ATTCTTTTCT AGGCACTAAG 1860

CTAGAATACC GAAGGCTTTA TAGCGTGTAT CTCAATTATG TGTTTGCTTA TTAA 1914

(2) INFORMATION FOR SEQ ID NO: 1296:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 897 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...897

( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 1296 :

Met Glu Gin Pro Val He Lys Glu Gly Thr Leu Ala Leu He Asp Thr

1 5 10 15

Phe Ala Tyr Leu Phe Arg Ser Tyr Tyr Met Ser Ala Lys Asn Lys Pro

20 25 30

Leu Thr Asn Asp Lys Gly Phe Pro Thr Gly Leu Leu Thr Gly Leu Val

35 40 45

Gly Met Val Lys Lys Phe Tyr Lys Asp Arg Lys Asn Met Pro Phe He

50 55 60

Val Phe Ala Leu Glu Ser Gin Thr Lys Thr Lys Arg Ala Glu Lys Leu 65 70 75 80

Gly Glu Tyr Lys Gin Asn Arg Lys Asp Ala Pro Lys Glu Met Leu Leu

85 90 95

Gin He Pro He Ala Leu Glu Trp Leu Gin Lys Met Gly Phe Thr Cys

100 105 110

Val Glu Val Gly Gly Phe Glu Ala Asp Asp Val He Ala Ser Leu Ala

115 120 125

Thr Leu Ser Pro Tyr Lys Thr Arg He Tyr Ser Lys Asp Lys Asp Phe

130 135 140

Asn Gin Leu Leu Ser Asp Lys He Ala Leu Phe Asp Gly Lys Thr Glu 145 150 155 160

Phe Leu Ala Lys Asp Cys Val Glu Lys Tyr Gly He Leu Pro Ser Gin

165 170 175

Phe Thr Asp Tyr Gin Gly He Val Gly Asp Ser Ser Asp Asn Tyr Lys

180 185 190

Gly Val Lys Gly He Gly Ser Lys Asn Ala Lys Glu Leu Leu Gin Arg

195 200 205

Leu Gly Ser Leu Glu Lys He Tyr Glu Asn Leu Asp Leu Ala Lys Asn

210 215 220

Leu Leu Ser Pro Lys Met Tyr Gin Ala Leu He Gin Asp Lys Gly Ser 225 230 235 240

Ala Phe Leu Ser Lys Glu Leu Ala Thr Leu Glu Arg Gly Cys He Lys

245 250 255

Glu Phe Asp Phe Leu Ser Cys Ala Phe Pro Ser Glu Asn Pro Leu Leu

260 265 270

Lys He Lys Asp Glu Leu Lys Glu Tyr Gly Phe He Ser Thr Leu Arg

275 280 285

Asp Leu Glu Asn Ser Pro Phe He Val Glu Asn Val Pro He Leu Asn

290 295 300

Ser Thr Pro He Leu Asp Asn Thr Pro Ala Leu Asp Asn Ala Pro Lys 305 310 315 320

Lys Ser Arg Met He Val Leu Glu Ser Ala Glu Pro Leu Ser Met Phe

325 330 335

Leu Glu Lys Leu Glu Asn Pro Asn Ala Arg Val Phe Met Arg Leu Val

340 345 350

Leu Asp Lys Asp Lys Lys He Leu Ala Leu Ala Phe Leu Leu Gin Asp

355 360 365

Gin Gly Tyr Phe Leu Pro Leu Glu Glu Ala Leu Phe Ser Pro Phe Ser

370 375 380

Leu Glu Phe Leu Gin Asn Ala Phe Ser Gin Met Leu Gin His Ala Cys 385 390 395 400

He He Gly His Asp Leu Lys Pro Leu Leu Ser Phe Leu Lys Ala Lys

405 410 415

Tyr Gin Val Pro Leu Glu Asn He Arg He Gin Asp Thr Gin He Leu

420 425 430

Ala Phe Leu Lys Asn Pro Glu Lys Val Gly Phe Asp Glu Val Leu Lys

435 440 445

Glu Tyr Leu Lys Glu Asp Leu He Pro His Glu Lys He Lys Asp Phe

450 455 460

Lys Thr Lys Ser Lys Ala Glu Lys Ser Glu Leu Leu Ser Met Glu Leu 465 470 475 480

Asn Ala Leu Lys Arg Leu Cys Glu Tyr Phe Glu Lys Gly Gly Leu Glu

485 490 495

Glu Asp Leu Leu Thr Leu Ala Arg Asp He Glu Thr Pro Phe Val Lys

500 505 510

Val Leu Met Gly Met Glu Phe Gin Gly Phe Lys He Asp Ala Pro Tyr 515 520 525 Phe Lys Arg Leu Glu Gin Glu Phe Lys Asn Glu Leu Asn Val Leu Glu

530 535 540

Arg Gin He Leu Asp Leu He Gly Val Asp Phe Asn Leu Asn Ser Pro 545 550 555 560

Lys Gin Leu Gly Glu Val Leu Tyr Asp Lys Leu Gly Leu Pro Lys Asn

565 570 575

Lys Ser His Ser Thr Asp Glu Lys Asn Leu Leu Lys He Leu Asp Lys

580 585 590

His Pro Ser He Pro Leu He Leu Glu Tyr Arg Glu Leu Asn Lys Leu

595 600 605

Phe Asn Thr Tyr Thr Thr Pro Leu Leu Arg Leu Lys Asp Lys Asp Asp

610 615 620

Lys He His Thr Thr Phe He Gin Thr Gly Thr Ala Thr Gly Arg Leu 625 630 635 640

Ser Ser His Ser Pro Asn Leu Gin Asn He Pro Val Arg Ser Pro Lys

645 650 655

Gly Leu Leu He Arg Lys Gly Phe He Ala Ser Ser Lys Glu Tyr Cys

660 665 670

Leu Leu Gly Val Asp Tyr Ser Gin He Glu Leu Arg Leu Leu Ala His

675 680 685

Phe Ser Gin Asp Lys Asp Leu Met Glu Ala Phe Leu Lys Gly Arg Asp

690 695 700

He His Leu Glu Thr Ser Lys Ala Leu Phe Gly Glu Asp Leu Ala Lys 705 710 715 720

Glu Lys Arg Ser He Ala Lys Ser He Asn Phe Gly Leu Val Tyr Gly

725 730 735

Met Gly Ser Lys Lys Leu Ser Glu Thr Leu Ser He Pro Leu Ser Glu

740 745 750

Ala Lys Ser Tyr He Glu Ala Tyr Phe Lys Arg Phe Pro Ser He Lys

755 760 765

Asp Tyr Leu Asn Gly Met Arg Glu Glu He Leu Lys Thr Ser Lys Ala

770 775 780

Phe Thr Leu Leu Gly Arg Tyr Arg Val Phe Asp Phe Thr Gly Val Asn 785 790 795 800

Asp Tyr Val Lys Gly Asn Tyr Leu Arg Glu Gly Val Asn Ala He Phe

805 810 815

Gin Gly Ser Ala Ser Asp Leu Leu Lys Leu Gly Met Leu Lys Val Ser

820 825 830

Glu Arg Phe Lys Asn Asn Pro Ser Val Arg Leu Leu Leu Gin Val His

835 840 845

Asp Glu Leu He Phe Glu He Glu Glu Lys Asn Ala Pro Glu Leu Gin

850 855 860

Gin Glu He Gin Arg He Leu Asn Asp Glu Val Tyr Pro Leu Arg Val 865 870 875 880

Pro Leu Glu Thr Ser Ala Phe He Ala Lys Arg Trp Asn Glu Leu Lys

885 890 895

Gly

(2) INFORMATION FOR SEQ ID NO: 1297:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 668 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A ) NAME/KEY : miscjeature

( B ) LOCATION 1 . . . 668

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1297:

Met Lys Lys Pro Phe Tyr Ser Leu Ser Leu Ala Ser Ser Leu Leu Asn

1 5 10 15

Ala Glu Asp Asn Gly Phe Phe He Ser Ala Gly Tyr Gin He Gly Glu

20 25 30

Ala Ala Gin Met Val Lys Asn Thr Gly Glu Leu Lys Lys Leu Ser Asp

35 40 45

Thr Tyr Glu Asn Leu Ser Asn Leu Leu Thr Asn Phe Asn Asn Leu Asn

50 55 60

Gin Ala Val Thr Asn Ala Ser Ser Pro Ser Glu He Asn Ala Ala He 65 70 75 80

Asp Asn Leu Lys Ala Asn Thr Gin Gly Leu He Gly Glu Lys Thr Asn

85 90 95

Ser Pro Ala Tyr Gin Ala Val Tyr Leu Ala Leu Asn Ala Ala Val Gly

100 105 110

Leu Trp Asn Val He Ala Tyr Asn Val Gin Cys Gly Pro Gly Asn Ser

115 120 125

Gly Gin Gin Ser Val Thr Phe Glu Gly Gin Pro Gly His Asn Ser Ser

130 135 140

Ser He Asn Cys Asn Leu Thr Gly Tyr Asn Asn Gly Val Ser Gly Pro 145 150 155 160

Leu Ser He Glu Asn Phe Lys Lys Leu Asn Gin Ala Tyr Gin Thr He

165 170 175

Gin Gin Ala Leu Lys Gin Asp Ser Gly Phe Pro Val Leu Asp Ser Ala

180 185 190

Gly Lys Gin Val Thr He Thr He Thr Thr Gin Thr Asn Gly Ala Asn

195 200 205

Lys Ser Glu Thr Thr Thr Thr Thr Thr Thr Thr Asn Asp Ala Gin Thr

210 215 220

Leu Leu Gin Glu Ala Ser Lys Met He Ser Val Leu Thr Thr Asn Cys 225 230 235 240

Pro Trp Val Asn His Asn Gin Gly Gin Asn Gly Gly Ala Pro Trp Gly

245 250 255

Leu Asp Thr Ala Gly Asn Val Cys Gin Val Phe Ala Thr Glu Phe Ser

260 265 270

Ala Val Thr Ser Met He Lys Asn Ala Gin Glu He Val Thr Gin Ala

275 280 285

Gin Ser Leu Asn Gin Gin Asn Asn Gin Asn Ala Pro Gin Asp Phe Asn

290 295 300

Pro Tyr Thr Ser Ala Asp Arg Ala Phe Ala Gin Asn Met Leu Asn His 305 310 315 320

Ala Gin Ala Gin Ala Lys He Leu Glu Leu Ala Asp Gin Met Lys Lys

325 330 335

Asp Leu Asn Thr He Pro Ser Gin Phe He Thr Asn Tyr Leu Ala Ala

340 345 350

Cys His Asn Gly Gly Gly Thr Leu Pro Asp Ala Gly Val Thr Asn Asn 355 360 365

Thr Trp Gly Ala Gly Cys Ala Tyr Val Glu Glu Thr He Thr Ala Leu

370 375 380

Asn Asn Ser Leu Ala His Phe Gly Thr Gin Ala Glu Gin He Lys Gin 385 390 395 400

Ser Glu Leu Leu Ala Arg Thr He Leu Asp Phe Arg Gly Ser Leu Ser

405 410 415

Asn Leu Asn Asn Thr Tyr Asn Ser He Thr Thr Thr Ala Ser Asn Thr

420 425 430

Pro Asn Ser Pro Phe Leu Lys Asn Leu He Ser Gin Ser Thr Asn Pro

435 440 445

Asn Asn Pro Gly Gly Leu Gin Ala Val Tyr Gin Val Asn Gin Ser Ala

450 455 460

Tyr Ser Gin Leu Leu Ser Ala Thr Gin Glu Leu Gly His Asn Pro Phe 465 470 475 480

Arg Arg Val Gly Leu He Ser Ser Gin Thr Asn Asn Gly Ala Met Asn

485 490 495

Gly He Gly Val Gin Val Gly Tyr Lys Gin Phe Phe Gly Glu Lys Arg

500 505 510

Arg Trp Gly Leu Arg Tyr Tyr Gly Phe Phe Asp Tyr Asn His Ala Tyr

515 520 525

He Lys Ser Ser Phe Phe Asn Ser Ala Ser Asp Val Phe Thr Tyr Gly

530 535 540

Val Gly Thr Asp Val Leu Tyr Asn Phe He Asn Asp Lys Thr Thr Lys 545 550 555 560

Asn Ser Lys He Ser Phe Gly Val Phe Gly Gly He Ala Leu Ala Gly

565 570 575

Thr Ser Trp Leu Asn Ser Gin Tyr Val Asn Leu Ala Thr Phe Asn Asn

580 585 590

Phe Tyr Ser Ala Lys Met Asn Val Ala Asn Phe Gin Phe Leu Phe Asn

595 600 605

Leu Gly Leu Arg Met Asn Leu Ala Lys Asn Lys Lys Lys Ala Ser Asp

610 615 620

His Ala Ala Gin His Gly Val Glu Leu Gly Val Lys He Pro Thr He 625 630 635 640

Asn Thr Asn Tyr Tyr Ser Leu Leu Gly Thr Gin Leu Gin Tyr Arg Arg

645 650 655

Leu Tyr Ser Val Tyr Leu Asn Tyr Val Phe Ala Tyr 660 665

(2) INFORMATION FOR SEQ ID NO: 1298:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 637 amino acids

(B) TYPE: amino acid (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(iii) HYPOTHETICAL: YES

(vi) ORIGINAL SOURCE:

(A) ORGANISM: Helicobacter pylori

(ix) FEATURE:

(A) NAME/KEY: miscjeature

(B) LOCATION 1...637 (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1298:

Met Lys Arg Gin Phe Tyr Ser Leu Ser Leu Ser Leu Ala Ser Ser Leu

1 5 10 15

Leu His Ala Glu Asp Asn Gly Phe Phe Val Ser Ala Gly Tyr Gin He

20 25 30

Gly Glu Ala Val Gin Met Val Lys Asn Thr Gly Glu Leu Lys Asn Leu

35 40 45

Asn Asp Lys Tyr Glu Gin Leu Ser Gin Ser Leu Ala Gin Leu Ala Ser

50 55 60

Leu Lys Lys Ser He Gin Thr Ala Asn Asn He Gin Ala Val Asn Asn 65 70 75 80

Ala Leu Ser Asp Leu Lys Ser Phe Ala Ser Asn Asn His Thr Asn Lys

85 90 95

Glu Thr Ser Pro He Tyr Asn Thr Ala Gin Ala Val He Thr Ser Val

100 105 110

Leu Ala Phe Trp Ser Leu Tyr Ala Gly Asn Ala Leu Ser Phe His Val

115 120 125

Thr Gly Leu Asn Asp Gly Ser Asn Ser Pro Leu Gly Arg He His Arg

130 135 140

Asp Gly Asn Cys Thr Gly Leu Gin Gin Cys Phe Met Ser Lys Glu Thr 145 150 155 160

Tyr Asp Lys Met Lys Thr Leu Ala Glu Asn Leu Gin Lys Ala Gin Gly

165 170 175

Asn Leu Cys Ala Leu Ser Glu Cys Ser Ser Asn Gin Ser Asn Gly Gly

180 185 190

Lys Thr Ser Met Thr Thr Ala Leu Gin Thr Ala Gin Gin Leu Met Asp

195 200 205

Leu He Glu Gin Thr Lys Val Ser Met Val Trp Lys Asn He Val He

210 215 220

Ala Gly Val Thr Asn Lys Pro Asn Gly Ala Gly Ala He Thr Ser Thr 225 230 235 240

Gly His Val Thr Asp Tyr Ala Val Phe Asn Asn He Lys Ala Met Leu

245 250 255

Pro He Leu Gin Gin Ala Leu Thr Leu Ser Gin Ser Asn His Thr Leu

260 265 270

Ser Thr Gin Leu Gin Ala Arg Ala Met Gly Ser Gin Thr Asn Arg Glu

275 280 285

Phe Ala Lys Asp He Tyr Ala Leu Ala Gin Asn Gin Lys Gin He Leu

290 295 300

Ser Asn Ala Ser Ser He Phe Asn Leu Phe Asn Ser He Pro Lys Asp 305 310 315 320

Gin Leu Lys Tyr Leu Glu Asn Ala Tyr Leu Lys Val Pro His Leu Gly

325 330 335

Lys Thr Pro Thr Asn Pro Tyr Arg Gin Asn Val Asn Leu Asn Lys Glu

340 345 350

He Asn Ala Val Gin Asp Asn Val Ala Asn Tyr Gly Asn Arg Leu Asp

355 360 365

Ser Ala Leu Ser Val Ala Lys Asp Val Tyr Asn Leu Lys Ser Asn Gin

370 375 380

Thr Glu He Val Thr Thr Tyr Asn Asp Ala Lys Asn Leu Ser Glu Glu 385 390 395 400

He Ser Lys Leu Pro Tyr Asn Gin Val Asn Val Thr Asn He Val Met

405 410 415

Ser Pro Lys Asp Ser Thr Ala Gly Gin Tyr Gin He Asn Pro Glu Gin 420 425 430 Gin Ser Asn Leu Asn Gin Ala Leu Ala Ala Met Ser Asn Asn Pro Phe

435 440 445

Lys Lys Val Gly Met He Ser Ser Gin Asn Asn Asn Gly Ala Leu Asn

450 455 460

Gly Leu Gly Val Gin Val Gly Tyr Lys Gin Phe Phe Gly Glu Ser Lys 465 470 475 480

Arg Trp Gly Leu Arg Tyr Tyr Gly Phe Phe Asp Tyr Asn His Gly Tyr

485 490 495

He Lys Ser Ser Phe Phe Asn Ser Ser Ser Asp He Trp Thr Tyr Gly

500 505 510

Gly Gly Ser Asp Leu Leu Val Asn Phe He Asn Asp Ser He Thr Arg

515 520 525

Lys Asn Asn Lys Leu Ser Val Gly Leu Phe Gly Gly He Gin Leu Ala

530 535 540

Gly Thr Thr Trp Leu Asn Ser Gin Tyr Met Asn Leu Thr Ala Phe Asn 545 550 555 560

Asn Pro Tyr Ser Ala Lys Val Asn Ala Ser Asn Phe Gin Phe Leu Phe

565 570 575

Asn Leu Gly Leu Arg Thr Asn Leu Ala Thr Ala Lys Lys Lys Asp Ser

580 585 590

Glu Arg Ser Ala Gin His Gly Val Glu Leu Gly He Lys He Pro Thr

595 600 605

He Asn Thr Asn Tyr Tyr Ser Phe Leu Gly Thr Lys Leu Glu Tyr Arg

610 615 620

Arg Leu Tyr Ser Val Tyr Leu Asn Tyr Val Phe Ala Tyr 625 630 635

Claims

1. An isolated nucleic acid comprising a nucleotide sequence encoding an H. pylori polypeptide selected from the group consisting of SEQ ID NO: 492-SEQ ID NO: 759, SEQ ID NO: 761 , SEQ ID NO: 763, SEQ ID NO: 765-SEQ ID NO: 818, SEQ ID NO: 820-SEQ ID NO: 846, SEQ ID NO: 848-SEQ ID NO: 896, SEQ ID NO: 898- SEQ ID NO: 963, SEQ ID NO: 966-SEQ ID NO: 982, SEQ ID NO: 1037, SEQ ID NO: 1038, SEQ ID NO: 1041-SEQ ID NO: 1087, SEQ ID NO:1090 and SEQ ID NO: 1296- SEQ ID NO: 1298.

2. A recombinant expression vector comprising the nucleic acid of claim 1 operably linked to a transcription regulatory element.

3. A cell comprising a recombinant expression vector of claim 2.

4. A method for producing an H. pylori polypeptide comprising culturing a cell of claim 3 under conditions that permit expression of the polypeptide.

5. A probe comprising a nucleotide sequence consisting of at least 8 nucleotides of a nucleotide sequence selected from the group consisting of SEQ ID NO: 1-SEQ ID NO: 268, SEQ ID NO: 270, SEQ ID NO: 272, SEQ ID NO: 274-SEQ ID NO: 327, SEQ ID NO: 329-SEQ ID NO: 364, SEQ ID NO: 366-SEQ ID NO: 405, SEQ ID NO: 407-SEQ ID NO: 472, SEQ ID NO: 475-SEQ ID NO: 491, SEQ ID NO: 983, SEQ ID NO: 984, SEQ ID NO: 987-SEQ ID NO: 1033, SEQ ID NO: 1036 and SEQ ID NO: 1293-SEQ ID NO: 1295 or the complement thereof.

6. An isolated nucleic acid comprising a nucleotide sequence of at least 8 nucleotides in length, wherein the sequence is hybridizable to a nucleic acid having a nucleotide sequence selected from the group consisting of SEQ ID NO: 1-SEQ ID NO: 268, SEQ ID NO: 270, SEQ ID NO: 272, SEQ ID NO: 274-SEQ ID NO: 327, SEQ ID NO: 329-SEQ ID NO: 364, SEQ ID NO: 366-SEQ ID NO: 405, SEQ ID NO: 407-SEQ ID NO: 472, SEQ ID NO: 475-SEQ ID NO: 491, SEQ ID NO: 983, SEQ ID NO: 984, SEQ ID NO: 987-SEQ ID NO: 1033, SEQ ID NO: 1036 and SEQ ID NO: 1293-SEQ ID NO: 1295 or the complement thereof.

7. A vaccine composition for prevention or treatment of an H. pylori infection comprising an effective amount of an isolated nucleic acid comprising a nucleotide sequence encoding an H. pylori polypeptide or a fragment thereof, said nucleic acid comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 1-SEQ ID NO: 268, SEQ ID NO: 270, SEQ ID NO: 272, SEQ ID NO: 274-SEQ ID NO: 327, SEQ ID NO: 329-SEQ ID NO: 364, SEQ ID NO: 366-SEQ ID NO: 405, SEQ ID NO: 407-SEQ ID NO: 472, SEQ ID NO: 475-SEQ ID NO: 491, SEQ ID NO: 983, SEQ ID NO: 984, SEQ ID NO: 987-SEQ ID NO: 1033, SEQ ID NO: 1036 and SEQ ID NO: 1293-SEQ ID NO: 1295.

8. A vaccine composition of claim 7, further comprising a pharmaceutically acceptable carrier.

9. A vaccine composition of claim 8, wherein the pharmaceutically acceptable carrier is an adjuvant.

10. A method of treating a subject for H. pylori infection comprising administering to a subject a vaccine composition of claim 7, such that treatment ofH pylori infection occurs.

11. A method of claim 10, wherein the treatment is a prophylactic treatment.

12. A method of claim 10, wherein the treatment is a therapeutic treatment.

13. A method for detecting the presence of a Helicobacter nucleic acid in a sample comprising:

(a) contacting a sample with a probe of claim 5 under conditions in which a hybrid can form between the probe and a Helicobacter nucleic acid in the sample; and (b) detecting the hybrid formed in step (a), wherein detection of a hybrid indicates the presence of a Helicobacter nucleic acid in the sample.

14. A recombinant or substantially pure preparation of an H. pylori polypeptide selected from the group consisting of SEQ ID NO: 492-SEQ ID NO: 759, SEQ ID NO: 761, SEQ ID NO: 763, SEQ ID NO: 765-SEQ ID NO: 818, SEQ ID NO: 820-SEQ ID NO: 846, SEQ ID NO: 848-SEQ ID NO: 896, SEQ ID NO: 898-SEQ ID NO: 963, SEQ ID NO: 966-SEQ ID NO: 982, SEQ ID NO: 1037, SEQ ID NO: 1038, SEQ ID NO: 1041 -SEQ ID NO: 1087, SEQ ID NO: 1090 and SEQ ID NO: 1296-SEQ ID NO: 1298.

15. A vaccine composition for prevention or treatment of an H. pylori infection comprising an effective amount of a purified H. pylori polypeptide or a fragment thereof, wherein said H. pylori polypeptide is selected from the group consisting of SEQ ID NO: 492-SEQ ID NO: 759, SEQ ID NO: 761, SEQ ID NO: 763, SEQ ID NO: 765-SEQ ID NO: 818, SEQ ID NO: 820-SEQ ID NO: 846, SEQ ID NO: 848-SEQ ID NO: 896, SEQ ID NO: 898-SEQ ID NO: 963, SEQ ID NO: 966-SEQ ID NO: 982, SEQ ID NO: 1037, SEQ ID NO: 1038, SEQ ID NO: 1041-SEQ ID NO: 1087, SEQ ID NO:1090 and SEQ ID NO: 1296-SEQ ID NO: 1298.

16. A vaccine composition of claim 15, further comprising a pharmaceutically acceptable carrier.

17. A vaccine composition of claim 16, wherein the pharmaceutically acceptable carrier is an adjuvant.

18. A method of treating a subject for H. pylori infection comprising administering to a subject a vaccine composition of claim 15, such that treatment ofH. pylori infection occurs.

19. A method of claim 18, wherein the treatment is a prophylactic treatment.

20. A method of claim 18, wherein the treatment is a therapeutic treatment.

21. An isolated nucleic acid comprising a nucleotide sequence encoding an H. pylori cell envelope polypeptide or a fragment thereof, said nucleic acid selected from the group consisting of SEQ ID NO: 255, SEQ ID NO: 263, SEQ ID NO: 266, SEQ ID NO: 277, SEQ ID NO: 280, SEQ ID NO: 285, SEQ ID NO: 292, SEQ ID NO: 294, SEQ ID NO: 299, SEQ ID NO: 311 , SEQ ID NO: 312, SEQ ID NO: 313, SEQ ID NO: 321, SEQ ID NO: 327, SEQ ID NO: 329, SEQ ID NO: 331, SEQ ID NO: 353, SEQ ID NO: 364, SEQ ID NO: 366, SEQ ID NO: 368, SEQ ID NO: 375, SEQ ID NO: 384, SEQ ID NO: 391, SEQ ID NO: 392, SEQ ID NO: 397, SEQ ID NO: 398, SEQ ID NO: 402, SEQ ID NO: 404, SEQ ID NO: 409, SEQ ID NO: 410, SEQ ID NO: 412, SEQ ID NO: 427, SEQ ID NO: 433, SEQ ID NO: 434, SEQ ID NO: 441, SEQ ID NO: 444, SEQ ID NO: 445, SEQ ID NO: 449, SEQ ID NO: 450, SEQ ID NO: 452, SEQ ID NO: 453, SEQ ID NO: 466, SEQ ID NO: 468, SEQ ID NO: 469, SEQ ID NO: 983, SEQ ID NO: 989, SEQ ID NO: 1008, SEQ ID NO: 1011, SEQ ID NO: 1014, SEQ ID NO: 1015, SEQ ID NO: 1029, SEQ ID NO: 1032, SEQ ID NO: 259, SEQ ID NO: 286, SEQ ID NO: 326, SEQ ID NO: 374, SEQ ID NO: 399, SEQ ID NO: 422, SEQ ID NO: 454, SEQ ID NO: 465, SEQ ID NO: 998, SEQ ID NO: 1009, SEQ ID NO: 1023, SEQ ID NO: 1294, SEQ ID NO: 1295, SEQ ID NO: 319, SEQ ID NO: 325, SEQ ID NO: 425, SEQ ID NO: 437, SEQ ID NO: 438, SEQ ID NO: 447, SEQ ID NO: 448, SEQ ID NO: 467, SEQ ID NO: 996, SEQ ID NO: 1027, SEQ ID NO: 1031, SEQ ID NO: 254, SEQ ID NO: 352, SEQ ID NO: 415, SEQ ID NO: 1019, SEQ ID NO: 381, SEQ ID NO: 389, SEQ ID NO: 1010, SEQ ID NO: 1012, SEQ ID NO: 354, SEQ ID NO: 372, SEQ ID NO: 400, SEQ ID NO: 421, SEQ ID NO: 1022, SEQ ID NO: 463, SEQ ID NO: 281, SEQ ID NO: 988, SEQ ID NO: 411, SEQ ID NO: 407, SEQ ID NO: 1017, SEQ ID NO: 290, SEQ ID NO: 417, SEQ ID NO: 430, SEQ ID NO: 992, SEQ ID NO: 1025, SEQ ID NO: 477, SEQ ID NO: 414, SEQ ID NO: 253, SEQ ID NO: 293, SEQ ID NO: 334, SEQ ID NO: 343, SEQ ID NO: 418, SEQ ID NO: 424, and SEQ ID NO: 443.

22. The purified nucleic acid of claim 21 , wherein said H. pylori cell envelope polypeptide or a fragment thereof is an H. pylori outer membrane polypeptide or a fragment thereof encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 255, SEQ ID NO: 263, SEQ ID NO: 266, SEQ ID NO: 277, SEQ ID NO: 280, SEQ ID NO: 285, SEQ ID NO: 292, SEQ ID NO: 294, SEQ ID NO: 299, SEQ ID NO: 311, SEQ ID NO: 312, SEQ ID NO: 313, SEQ ID NO: 321, SEQ ID NO: 327, SEQ ID NO: 329, SEQ ID NO: 331, SEQ ID NO: 353, SEQ ID NO: 364, SEQ ID NO: 366, SEQ ID NO: 368, SEQ ID NO: 375, SEQ ID NO: 384, SEQ ID NO: 391, SEQ ID NO: 392, SEQ ID NO: 397, SEQ ID NO: 398, SEQ ID NO: 402, SEQ ID NO: 404, SEQ ID NO: 409, SEQ ID NO: 410, SEQ ID NO: 412, SEQ ID NO: 427, SEQ ID NO: 433, SEQ ID NO: 434, SEQ ID NO: 441 , SEQ ID NO: 444, SEQ ID NO: 445, SEQ ID NO: 449, SEQ ID NO: 450, SEQ ID NO: 452, SEQ ID NO: 453, SEQ ID NO: 466, SEQ ID NO: 468, SEQ ID NO: 469, SEQ ID NO: 983, SEQ ID NO: 989, SEQ ID NO: 1008, SEQ ID NO: 1011, SEQ ID NO: 1014, SEQ ID NO: 1015, SEQ ID NO: 1029, SEQ ID NO: 1032, SEQ ID NO: 259, SEQ ID NO: 286, SEQ ID NO: 326, SEQ ID NO: 374, SEQ ID NO: 399, SEQ ID NO: 422, SEQ ID NO: 454, SEQ ID NO: 465, SEQ ID NO: 998, SEQ ID NO: 1009, SEQ ID NO: 1023, SEQ ID NO: 1294, SEQ ID NO: 1295, SEQ ID NO: 319, SEQ ID NO: 325, SEQ ID NO: 425, SEQ ID NO: 437, SEQ ID NO: 438, SEQ ID NO: 447, SEQ ID NO: 448, SEQ ID NO: 467, SEQ ID NO: 996, SEQ ID NO: 1027, SEQ ID NO: 1031, SEQ ID NO: 254, SEQ ID NO: 352, SEQ ID NO: 415, SEQ ID NO: 1019, SEQ ID NO: 381, SEQ ID NO: 389, SEQ ID NO: 1010, and SEQ ID NO: 1012.

23. he purified nucleic acid of claim 22, wherein said H pylori outer membrane polypeptide or a fragment thereof is an H. pylori polypeptide having a terminal phenylalanine residue or a fragment thereof encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 255, SEQ ID NO: 263, SEQ ID NO: 266, SEQ ID NO: 277, SEQ ID NO: 280, SEQ ID NO: 285, SEQ ID NO: 292, SEQ ID NO: 294, SEQ ID NO: 299, SEQ ID NO: 311, SEQ ID NO: 312, SEQ ID NO: 313, SEQ ID NO: 321, SEQ ID NO: 327, SEQ ID NO: 329, SEQ ID NO: 331, SEQ ID NO: 353, SEQ ID NO: 364, SEQ ID NO: 366, SEQ ID NO: 368, SEQ ID NO: 375, SEQ ID NO: 384, SEQ ID NO: 391, SEQ ID NO: 392, SEQ ID NO: 397, SEQ ID NO: 398, SEQ ID NO: 402, SEQ ID NO: 404, SEQ ID NO: 409, SEQ ID NO: 410, SEQ ID NO: 412, SEQ ID NO: 427, SEQ ID NO: 433, SEQ ID NO: 434, SEQ ID NO: 441, SEQ ID NO: 444, SEQ ID NO: 445, SEQ ID NO: 449, SEQ ID NO: 450, SEQ ID NO: 452, SEQ ID NO: 453, SEQ ID NO: 466, SEQ ID NO: 468, SEQ ID NO: 469, SEQ ID NO: 983, SEQ ID NO: 989, SEQ ID NO: 1008, SEQ ID NO: 1011, SEQ ID NO: 1014, SEQ ID NO: 1015, SEQ ID NO: 1029, and SEQ ID NO: 1032.

24. The purified nucleic acid of claim 22, wherein said H. pylori outer membrane polypeptide or a fragment thereof is an H. pylori polypeptide having a C- terminal tyrosine cluster or a fragment thereof encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 286, SEQ ID NO: 326, SEQ ID NO: 374, SEQ ID NO: 399, SEQ ID NO: 422, SEQ ID NO: 454, SEQ ID NO: 465, SEQ ID NO: 998, SEQ ID NO: 1009, SEQ ID NO: 1023, SEQ ID NO: 1294, and SEQ ID NO: 1295.

25. The purified nucleic acid of claim 22, wherein said H. pylori outer membrane polypeptide or a fragment thereof is an H. pylori polypeptide having a terminal phenylalanine residue and a C-terminal tyrosine cluster or a fragment thereof encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 319, SEQ ID NO: 325, SEQ ID NO: 425, SEQ ID NO: 437, SEQ ID NO: 438, SEQ ID NO: 447, SEQ ID NO: 448, SEQ ID NO: 467, SEQ ID NO: 996, SEQ ID NO: 1027, and SEQ ID NO: 1031.

26. The purified nucleic acid of claim 21 , wherein said H. pylori cell envelope polypeptide or a fragment thereof is an H. pylori inner membrane polypeptide or a fragment thereof encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 354, SEQ ID NO: 372, SEQ ID NO: 400, SEQ ID NO: 421, SEQ ID NO: 1022, SEQ ID NO: 463, SEQ ID NO: 281, SEQ ID NO: 988, SEQ ID NO: 41 1, SEQ ID NO: 407, SEQ ID NO: 1017, SEQ ID NO: 290, SEQ ID NO: 417, SEQ ID NO: 430, SEQ ID NO: 992, and SEQ ID NO: 1025.

27. The purified nucleic acid of claim 26, wherein said H. pylori inner membrane polypeptide or a fragment thereof is an H pylori polypeptide involved in outer membrane and cell wall synthesis or a fragment thereof encoded by the nucleic acid comprising a nucleotide sequence of SEQ ID NO: 354.

28. The purified nucleic acid of claim 26, wherein said H. pylori inner membrane polypeptide or a fragment thereof is an H pylori polypeptide involved in energy conversion or a fragment thereof encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 372, SEQ ID NO: 400, SEQ ID NO: 421, and SEQ ID NO: 1022.

29. The purified nucleic acid of claim 26, wherein said H. pylori inner membrane polypeptide or a fragment thereof is an H pylori polypeptide involved in cofactor metabolism or a fragment thereof encoded by the nucleic acid comprising a nucleotide sequence of SEQ ID NO: 463.

30. The purified nucleic acid of claim 26, wherein said H. pylori inner membrane polypeptide or a fragment thereof is an H. pylori polypeptide involved in secretion and adhesion or a fragment thereof encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 281 and SEQ ID NO: 988.

31. The purified nucleic acid of claim 26, wherein said H. pylori inner membrane polypeptide or a fragment thereof is an H. pylori polypeptide involved in transport or a fragment thereof encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 407 and SEQ ID NO: 1017.

32. The purified nucleic acid of claim 21, wherein said H pylori cell envelope polypeptide or a fragment thereof is an H. pylori flagellar polypeptide or a fragment thereof encoded by the nucleic acid comprising a nucleotide sequence of SEQ ID NO: 477.

33. The purified nucleic acid of claim 21, wherein said H. pylori cell envelope polypeptide or a fragment thereof is an H. pylori transport polypeptide or a fragment thereof encoded by the nucleic acid comprising a nucleotide sequence of SEQ ID NO: 414.

34. A recombinant expression vector comprising the nucleic acid of claim 21 operably linked to a transcription regulatory element.

35. A cell comprising a recombinant expression vector of claim 34.

36. A method for producing an H. pylori polypeptide comprising culturing a cell of claim 35 under conditions that permit expression of the polypeptide.

37. An isolated nucleic acid comprising a nucleotide sequence encoding an H pylori secreted polypeptide or a fragment thereof, said nucleic acid selected from the group consisting of SEQ ID NO: 355, SEQ ID NO: 1006, SEQ ID NO: 257, SEQ ID NO: 258, SEQ ID NO: 260, SEQ ID NO: 261, SEQ ID NO: 264, SEQ ID NO: 265, SEQ ID NO: 268, SEQ ID NO: 270, SEQ ID NO: 272, SEQ ID NO: 274, SEQ ID NO: 275, SEQ ID NO: 276, SEQ ID NO: 279, SEQ ID NO: 283, SEQ ID NO: 284, SEQ ID NO: 287, SEQ ID NO: 288, SEQ ID NO: 289, SEQ ID NO: 291, SEQ ID NO: 295, SEQ ID NO: 296, SEQ ID NO: 297, SEQ ID NO: 298, SEQ ID NO: 300, SEQ ID NO: 301, SEQ ID NO: 302, SEQ ID NO: 303, SEQ ID NO: 304, SEQ ID NO: 305, SEQ ID NO: 314, SEQ ID NO: 315, SEQ ID NO: 323, SEQ ID NO: 338, SEQ ID NO: 342, SEQ ID NO: 348, SEQ ID NO: 349, SEQ ID NO: 356, SEQ ID NO: 358, SEQ ID NO: 359, SEQ ID NO: 360, SEQ ID NO: 361, SEQ ID NO: 362, SEQ ID NO: 363, SEQ ID NO: 367, SEQ ID NO: 370, SEQ ID NO: 371, SEQ ID NO: 373, SEQ ID NO: 377, SEQ ID NO: 378, SEQ ID NO: 379, SEQ ID NO: 380, SEQ ID NO: 388, SEQ ID NO: 390, SEQ ID NO: 394, SEQ ID NO: 395, SEQ ID NO: 396, SEQ ID NO: 401, SEQ ID NO: 403, SEQ ID NO: 405, SEQ ID NO: 408, SEQ ID NO: 420, SEQ ID NO: 426, SEQ ID NO: 428, SEQ ID NO: 429, SEQ ID NO: 432, SEQ ID NO: 439, SEQ ID NO: 442, SEQ ID NO: 451, SEQ ID NO: 471, SEQ ID NO: 478, SEQ ID NO: 488, SEQ ID NO: 987, SEQ ID NO: 990, SEQ ID NO: 991, SEQ ID NO: 993, SEQ ID NO: 1001, SEQ ID NO: 1002, SEQ ID NO: 1007, SEQ ID NO: 1013, SEQ ID NO: 1016, SEQ ID NO: 1018, SEQ ID NO: 1021, and SEQ ID NO: 1026.

38. The purified nucleic acid of claim 37, wherein said H. pylori secreted polypeptide or a fragment thereof is an H. pylori polypeptide involved in secretion and adhesion or a fragment thereof encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 355 and SEQ ID NO: 1006.

39. A recombinant expression vector comprising the nucleic acid of claim 38 operably linked to a transcription regulatory element.

40. A cell comprising a recombinant expression vector of claim 39.

41. A method for producing an H. pylori polypeptide comprising culturing a cell of claim 40 under conditions that permit expression of the polypeptide.

42. An isolated nucleic acid comprising a nucleotide sequence encoding an H. pylori cytoplasmic polypeptide or a fragment thereof, said nucleic acid selected from the group consisting of SEQ ID NO: 470, SEQ ID NO: 1033, SEQ ID NO: 357, SEQ ID NO: 457, SEQ ID NO: 461, SEQ ID NO: 1030, SEQ ID NO: 345, SEQ ID NO: 383,

SEQ ID NO: 387, SEQ ID NO: 455, SEQ ID NO: 1003, SEQ ID NO: 351, SEQ ID NO: 416, SEQ ID NO: 278, SEQ ID NO: 335, SEQ ID NO: 346, SEQ ID NO: 350, SEQ ID NO: 419, SEQ ID NO: 460, SEQ ID NO: 472, SEQ ID NO: 1000, SEQ ID NO: 1004, SEQ ID NO: 1020, SEQ ID NO: 1293, SEQ ID NO: 318, SEQ ID NO: 322, SEQ ID NO: 324, SEQ ID NO: 330, SEQ ID NO: 347, SEQ ID NO: 440, SEQ ID NO: 446, SEQ ID NO: 464, SEQ ID NO: 490, SEQ ID NO: 491, SEQ ID NO: 995, SEQ ID NO: 997, SEQ ID NO: 1005, SEQ ID NO: 1028.

43. The purified nucleic acid of claim 42, wherein said H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide involved in energy conversion or a fragment thereof encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 470 and SEQ ID NO: 1033.

44. The purified nucleic acid of claim 42, wherein said H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide involved in amino acid metabolism and transport or a fragment thereof encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 357 and SEQ ID NO: 457.

45. The purified nucleic acid of claim 42, wherein said H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide involved in nucleotide metabolism and transport or a fragment thereof encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 461 and SEQ ID NO: 1030.

46. The purified nucleic acid of claim 42, wherein said H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide involved in cofactor metabolism or a fragment thereof encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 345, SEQ ID NO: 383, SEQ ID NO: 387, SEQ ID NO: 455, and SEQ ID NO: 1003.

47. The purified nucleic acid of claim 42, wherein said H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide involved in lipid metabolism or a fragment thereof encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 351 and SEQ ID NO: 416.

48. The purified nucleic acid of claim 42, wherein said H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide involved in genome replication, transcription, recombination and repair or a fragment thereof encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 278, SEQ ID NO: 335, SEQ ID NO: 346, SEQ ID NO: 350, SEQ ID NO: 419, SEQ ID NO: 460, SEQ ID NO: 472, SEQ ID NO: 1000, SEQ ID NO: 1004, SEQ ID NO: 1020, and SEQ ID NO: 1293.

49. A recombinant expression vector comprising the nucleic acid of claim 42 operably linked to a transcription regulatory element.

50. A cell comprising a recombinant expression vector of claim 49.

51. A method for producing an H. pylori polypeptide comprising culturing a cell of claim 50 under conditions that permit expression of the polypeptide.

52. An isolated nucleic acid comprising a nucleotide sequence encoding an

H. pylori cellular polypeptide or a fragment thereof, said nucleic acid selected from the group consisting of SEQ ID NO: 256, SEQ ID NO: 267, SEQ ID NO: 282, SEQ ID NO: 306, SEQ ID NO: 307, SEQ ID NO: 308, SEQ ID NO: 309, SEQ ID NO: 310, SEQ ID NO: 316, SEQ ID NO: 317, SEQ ID NO: 332, SEQ ID NO: 333, SEQ ID NO: 336, SEQ ID NO: 337, SEQ ID NO: 339, SEQ ID NO: 340, SEQ ID NO: 341, SEQ ID NO: 344, SEQ ID NO: 369, SEQ ID NO: 376, SEQ ID NO: 382, SEQ ID NO: 386, SEQ ID NO: 423, SEQ ID NO: 431, SEQ ID NO: 435, SEQ ID NO: 436, SEQ ID NO: 458, SEQ ID NO: 462, SEQ ID NO: 475, SEQ ID NO: 476, SEQ ID NO: 479, SEQ ID NO: 480, SEQ ID NO: 481, SEQ ID NO: 482, SEQ ID NO: 483, SEQ ID NO: 484, SEQ ID NO: 485, SEQ ID NO: 486, SEQ ID NO: 487, SEQ ID NO: 489, SEQ ID NO: 984, SEQ ID NO: 994, SEQ ID NO: 1024, and SEQ ID NO: 1036.

53. A recombinant expression vector comprising the nucleic acid of claim 52 operably linked to a transcription regulatory element.

54. A cell comprising a recombinant expression vector of claim 53.

55. A method for producing an H pylori polypeptide comprising culturing a cell of claim 54 under conditions that permit expression of the polypeptide.

56. A vaccine composition for prevention or treatment of an H pylori infection comprising an effective amount of a nucleic acid of claim 21.

57. A vaccine composition of claim 56, further comprising a pharmaceutically acceptable carrier.

58. A vaccine composition of claim 57, wherein the pharmaceutically acceptable carrier is an adjuvant.

59. A method of treating a subject for H. pylori infection comprising administering to a subject a vaccine composition of claim 56, such that treatment ofH. pylori infection occurs.

60. A method of claim 59, wherein the treatment is a prophylactic treatment.

61. A method of claim 59, wherein the treatment is a therapeutic treatment.

62. A vaccine composition for prevention or treatment of an H. pylori infection comprising an effective amount of a nucleic acid of claim 37.

63. A vaccine composition of claim 62, further comprising a pharmaceutically acceptable carrier.

64. A vaccine composition of claim 63, wherein the pharmaceutically acceptable carrier is an adjuvant.

65. A method of treating a subject for H. pylori infection comprising administering to a subject a vaccine composition of claim 62, such that treatment ofH. pylori infection occurs.

66. A method of claim 65, wherein the treatment is a prophylactic treatment.

67. A method of claim 65, wherein the treatment is a therapeutic treatment.

68. A vaccine composition for prevention or treatment of an H. pylori infection comprising an effective amount of a nucleic acid of claim 42.

69. A vaccine composition of claim 68, further comprising a pharmaceutically acceptable carrier.

70. A vaccine composition of claim 69, wherein the pharmaceutically acceptable carrier is an adjuvant.

71. A method of treating a subject for H. pylori infection comprising administering to a subject a vaccine composition of claim 68, such that treatment ofH. pylori infection occurs.

72. A method of claim 71 , wherein the treatment is a prophylactic treatment.

73. A method of claim 71 , wherein the treatment is a therapeutic treatment.

74. A vaccine composition for prevention or treatment of an H. pylori infection comprising an effective amount of a nucleic acid of claim 52.

75. A vaccine composition of claim 74, further comprising a pharmaceutically acceptable carrier.

76. A vaccine composition of claim 75, wherein the pharmaceutically acceptable carrier is an adjuvant.

77. A method of treating a subject for H. pylori infection comprising administering to a subject a vaccine composition of claim 74, such that treatment ofH. pylori infection occurs.

78. A method of claim 77, wherein the treatment is a prophylactic treatment.

79. A method of claim 77, wherein the treatment is a therapeutic treatment.

80. A purified H. pylori cell envelope polypeptide or a fragment thereof, wherein said polypeptide is selected from the group consisting of SEQ ID NO: 746, SEQ ID NO: 754, SEQ ID NO: 757, SEQ ID NO: 768, SEQ ID NO: 771, SEQ ID NO: 776, SEQ ID NO: 783, SEQ ID NO: 785, SEQ ID NO: 790, SEQ ID NO: 802, SEQ ID NO: 803, SEQ ID NO: 804, SEQ ID NO: 812, SEQ ID NO: 818, SEQ ID NO: 820, SEQ ID NO: 882, SEQ ID NO: 844, SEQ ID NO: 855, SEQ ID NO: 857, SEQ ID NO: 859, SEQ ID NO: 866, SEQ ID NO: 875, SEQ ID NO: 882, SEQ ID NO: 883, SEQ ID NO: 888, SEQ ID NO: 889, SEQ ID NO: 893, SEQ ID NO: 895, SEQ ID NO: 900, SEQ ID NO: 901, SEQ ID NO: 903, SEQ ID NO: 918, SEQ ID NO: 924, SEQ ID NO: 925, SEQ ID NO: 932, SEQ ID NO: 935, SEQ ID NO: 936, SEQ ID NO: 940, SEQ ID NO: 941, SEQ ID NO: 943, SEQ ID NO: 944, SEQ ID NO: 957, SEQ ID NO: 959, SEQ ID NO: 960, SEQ ID NO: 1037, SEQ ID NO: 1043, SEQ ID NO: 1062, SEQ ID NO: 1065, SEQ ID NO: 1068, SEQ ID NO: 1069, SEQ ID NO: 1083, SEQ ID NO: 1086, SEQ ID NO: 750, SEQ ID NO: 777, SEQ ID NO: 817, SEQ ID NO: 865, SEQ ID NO: 890, SEQ ID NO: 913, SEQ ID NO: 945, SEQ ID NO: 956, SEQ ID NO: 1052, SEQ ID NO: 1063, SEQ ID NO: 1077, SEQ ID NO: 1297, SEQ ID NO: 1298, SEQ ID NO: 810, SEQ ID NO: 816, SEQ ID NO: 916, SEQ ID NO: 928, SEQ ID NO: 929, SEQ ID NO: 938, SEQ ID NO: 939, SEQ ID NO: 958, SEQ ID NO: 1050, SEQ ID NO: 1081, SEQ ID NO: 1085, SEQ ID NO: 745, SEQ ID NO: 843, SEQ ID NO: 906, SEQ ID NO: 1073, SEQ ID NO: 872, SEQ ID NO: 880, SEQ ID NO: 1064, SEQ ID NO: 1066, SEQ ID NO:

845, SEQ ID NO: 863, SEQ ID NO: 891, SEQ ID NO: 912, SEQ ID NO: 1076, SEQ ID NO: 954, SEQ ID NO: 772, SEQ ID NO: 1042, SEQ ID NO: 902, SEQ ID NO: 898, SEQ ID NO: 1071, SEQ ID NO: 781, SEQ ID NO: 908, SEQ ID NO: 921, SEQ ID NO: 1046, SEQ ID NO: 1079, SEQ ID NO: 968, SEQ ID NO: 905, SEQ ID NO: 744, SEQ ID NO: 784, SEQ ID NO: 825, SEQ ID NO: 834, SEQ ID NO: 909, SEQ ID NO: 915, and SEQ ID NO: 934.

81. The purified polypeptide of claim 80, wherein said H. pylori cell envelope polypeptide or a fragment thereof is an H. pylori outer membrane polypeptide or a fragment thereof selected from the group consisting of SEQ ID NO: 746, SEQ ID NO: 754, SEQ ID NO: 757, SEQ ID NO: 768, SEQ ID NO: 771, SEQ ID NO: 776, SEQ ID NO: 783, SEQ ID NO: 785, SEQ ID NO: 790, SEQ ID NO: 802, SEQ ID NO: 803, SEQ ID NO: 804, SEQ ID NO: 812, SEQ ID NO: 818, SEQ ID NO: 820, SEQ ID NO: 882, SEQ ID NO: 844, SEQ ID NO: 855, SEQ ID NO: 857, SEQ ID NO: 859, SEQ ID NO: 866, SEQ ID NO: 875, SEQ ID NO: 882, SEQ ID NO: 883, SEQ ID NO: 888, SEQ ID NO: 889, SEQ ID NO: 893, SEQ ID NO: 895, SEQ ID NO: 900, SEQ ID NO: 901, SEQ ID NO: 903, SEQ ID NO: 918, SEQ ID NO: 924, SEQ ID NO: 925, SEQ ID NO: 932, SEQ ID NO: 935, SEQ ID NO: 936, SEQ ID NO: 940, SEQ ID NO: 941, SEQ ID NO: 943, SEQ ID NO: 944, SEQ ID NO: 957, SEQ ID NO: 959, SEQ ID NO: 960, SEQ ID NO: 1037, SEQ ID NO: 1043, SEQ ID NO: 1062, SEQ ID NO: 1065, SEQ ID NO: 1068, SEQ ID NO: 1069, SEQ ID NO: 1083, SEQ ID NO: 1086, SEQ ID NO: 750, SEQ ID NO: 777, SEQ ID NO: 817, SEQ ID NO: 865, SEQ ID NO: 890, SEQ ID NO: 913, SEQ ID NO: 945, SEQ ID NO: 956, SEQ ID NO: 1052, SEQ ID NO: 1063, SEQ ID NO: 1077, SEQ ID NO: 1297, SEQ ID NO: 1298, SEQ ID NO: 810, SEQ ID NO: 816, SEQ ID NO: 916, SEQ ID NO: 928, SEQ ID NO: 929, SEQ ID NO: 938, SEQ ID NO: 939, SEQ ID NO: 958, SEQ ID NO: 1050, SEQ ID NO: 1081, SEQ ID NO: 1085, SEQ ID NO: 745, SEQ ID NO: 843, SEQ ID NO: 906, SEQ ID NO: 1073, SEQ ID NO: 872, SEQ ID NO: 880, SEQ ID NO: 1064, and SEQ ID NO: 1066.

82. The purified polypeptide of claim 81 , wherein said H. pylori outer membrane polypeptide or a fragment thereof is an H. pylori polypeptide having a terminal phenylalanine residue or a fragment thereof selected from the group consisting of SEQ ID NO: 746, SEQ ID NO: 754, SEQ ID NO: 757, SEQ ID NO: 768, SEQ ID NO: 771, SEQ ID NO: 776, SEQ ID NO: 783, SEQ ID NO: 785, SEQ ID NO: 790, SEQ ID NO: 802, SEQ ID NO: 803, SEQ ID NO: 804, SEQ ID NO: 812, SEQ ID NO: 818, SEQ ID NO: 820, SEQ ID NO: 882, SEQ ID NO: 844, SEQ ID NO: 855, SEQ ID NO: 857, SEQ ID NO: 859, SEQ ID NO: 866, SEQ ID NO: 875, SEQ ID NO: 882, SEQ ID NO: 883, SEQ ID NO: 888, SEQ ID NO: 889, SEQ ID NO: 893, SEQ ID NO: 895, SEQ ID NO: 900, SEQ ID NO: 901, SEQ ID NO: 903, SEQ ID NO: 918, SEQ ID NO: 924, SEQ ID NO: 925, SEQ ID NO: 932, SEQ ID NO: 935, SEQ ID NO: 936, SEQ ID NO: 940, SEQ ID NO: 941, SEQ ID NO: 943, SEQ ID NO: 944, SEQ ID NO: 957, SEQ ID NO: 959, SEQ ID NO: 960, SEQ ID NO: 1037, SEQ ID NO: 1043, SEQ ID NO: 1062, SEQ ID NO: 1065, SEQ ID NO: 1068, SEQ ID NO: 1069, SEQ ID NO: 1083, and SEQ ID NO: 1086.

83. The purified polypeptide of claim 81 , wherein said H. pylori outer membrane polypeptide or a fragment thereof is an H. pylori polypeptide a C-terminal tyrosine cluster or a fragment thereof selected from the group consisting of SEQ ID NO: 746, SEQ ID NO: 754, SEQ ID NO: 757, SEQ ID NO: 768, SEQ ID NO: 771, SEQ ID NO: 776, SEQ ID NO: 783, SEQ ID NO: 785, SEQ ID NO: 790, SEQ ID NO: 802, SEQ ID NO: 803, SEQ ID NO: 804, SEQ ID NO: 812, SEQ ID NO: 818, SEQ ID NO: 820, SEQ ID NO: 882, SEQ ID NO: 844, SEQ ID NO: 855, SEQ ID NO: 857, SEQ ID NO: 859, SEQ ID NO: 866, SEQ ID NO: 875, SEQ ID NO: 882, SEQ ID NO: 883, SEQ ID NO: 888, SEQ ID NO: 889, SEQ ID NO: 893, SEQ ID NO: 895, SEQ ID NO: 900, SEQ ID NO: 901, SEQ ID NO: 903, SEQ ID NO: 918, SEQ ID NO: 924, SEQ ID NO: 925, SEQ ID NO: 932, SEQ ID NO: 935, SEQ ID NO: 936, SEQ ID NO: 940, SEQ ID NO: 941, SEQ ID NO: 943, SEQ ID NO: 944, SEQ ID NO: 957, SEQ ID NO: 959, SEQ ID NO: 960, SEQ ID NO: 1037, SEQ ID NO: 1043, SEQ ID NO: 1062, SEQ ID NO: 1065, SEQ ID NO: 1068, SEQ ID NO: 1069, SEQ ID NO: 1083, and SEQ ID NO: 1086.

84. The purified polypeptide of claim 81 , wherein said H. pylori outer membrane polypeptide or a fragment thereof is an H. pylori polypeptide having a terminal phenylalanine residue and a C-terminal tyrosine cluster or a fragment thereof selected from the group consisting of SEQ ID NO: 810, SEQ ID NO: 816, SEQ ID NO: 916, SEQ ID NO: 928, SEQ ID NO: 929, SEQ ID NO: 938, SEQ ID NO: 939, SEQ ID NO: 958, SEQ ID NO: 1050, SEQ ID NO: 1081, and SEQ ID NO: 1085.

85. The purified polypeptide of claim 80, wherein said H. pylori cell envelope polypeptide or a fragment thereof is an H. pylori inner membrane polypeptide or a fragment thereof selected from the group consisting of SEQ ID NO: 845, SEQ ID NO: 863, SEQ ID NO: 891, SEQ ID NO: 912, SEQ ID NO: 1076, SEQ ID NO: 954, SEQ ID NO: 772, SEQ ID NO: 1042, SEQ ID NO: 902, SEQ ID NO: 898, SEQ ID NO: 1071, SEQ ID NO: 781, SEQ ID NO: 908, SEQ ID NO: 921, SEQ ID NO: 1046, SEQ ID NO: 1079.

86. The purified polypeptide of claim 85, wherein said H. pylori inner membrane polypeptide or a fragment thereof is an H. pylori polypeptide involved in outer membrane and cell wall synthesis or a fragment thereof comprising an amino acid sequence of SEQ ID NO: 845.

87. The purified polypeptide of claim 85, wherein said H. pylori inner membrane polypeptide or a fragment thereof is an H. pylori polypeptide involved in energy conversion or a fragment thereof selected from the group consisting of SEQ ID NO: 863, SEQ ID NO: 891, SEQ ID NO: 912, and SEQ ID NO: 1076.

88. The purified polypeptide of claim 85, wherein said H. pylori inner membrane polypeptide or a fragment thereof is an H. pylori polypeptide involved in cofactor metabolism or a fragment thereof comprising an amino acid sequence of SEQ ID NO: 954.

89. The purified polypeptide of claim 85, wherein said H. pylori inner membrane polypeptide or a fragment thereof is an H. pylori polypeptide involved in secretion and adhesion or a fragment thereof selected from the group consisting of SEQ ID NO: 772 and SEQ ID NO: 1042.

90. The purified polypeptide of claim 85, wherein said H. pylori inner membrane polypeptide or a fragment thereof is an H. pylori polypeptide involved in transport or a fragment thereof selected from the group consisting of SEQ ID NO: 898 and SEQ ID NO: 1071.

91. The purified polypeptide of claim 80, wherein said H. pylori cell envelope polypeptide or a fragment thereof is an H. pylori flagellar polypeptide or a fragment thereof comprising an amino acid sequence of SEQ ID NO: 968.

92. The purified polypeptide of claim 80, wherein said H. pylori cell envelope polypeptide or a fragment thereof is an H. pylori transport polypeptide or a fragment thereof comprising an amino acid sequence of SEQ ID NO: 905.

93. A purified H. pylori cellular polypeptide or a fragment thereof, wherein said polypeptide is selected from the group consisting of SEQ ID NO: 747, SEQ ID NO: 758, SEQ ID NO: 773, SEQ ID NO: 797, SEQ ID NO: 798, SEQ ID NO: 799, SEQ ID NO: 800, SEQ ID NO: 801, SEQ ID NO: 807, SEQ ID NO: 808, SEQ ID NO: 823, SEQ ID NO: 824, SEQ ID NO: 827, SEQ ID NO: 828, SEQ ID NO: 830, SEQ ID NO: 831 , SEQ ID NO: 832, SEQ ID NO: 835, SEQ ID NO: 860, SEQ ID NO: 867, SEQ ID NO: 873, SEQ ID NO: 877, SEQ ID NO: 914, SEQ ID NO: 922, SEQ ID NO: 926, SEQ ID NO: 927, SEQ ID NO: 949, SEQ ID NO: 953, SEQ ID NO: 966, SEQ ID NO: 967, SEQ ID NO: 970, SEQ ID NO: 971, SEQ ID NO: 972, SEQ ID NO: 973, SEQ ID NO: 974, SEQ ID NO: 975, SEQ ID NO: 976, SEQ ID NO: 977, SEQ ID NO: 978, SEQ ID NO: 980, SEQ ID NO: 1038, SEQ ID NO: 1048, SEQ ID NO: 1078, and SEQ ID NO: 1090.

94. A purified H. pylori secreted polypeptide or a fragment thereof, wherein said polypeptide is selected from the group consisting of SEQ ID NO: 846, SEQ ID NO: 1060, SEQ ID NO: 748, SEQ ID NO: 749, SEQ ID NO: 751, SEQ ID NO: 752, SEQ ID NO: 755, SEQ ID NO: 756, SEQ ID NO: 759, SEQ ID NO: 761, SEQ ID NO: 763, SEQ ID NO: 765, SEQ ID NO: 766, SEQ ID NO: 767, SEQ ID NO: 770, SEQ ID NO: 774, SEQ ID NO: 775, SEQ ID NO: 778, SEQ ID NO: 779, SEQ ID NO: 780, SEQ ID NO: 782, SEQ ID NO: 786, SEQ ID NO: 787, SEQ ID NO: 788, SEQ ID NO: 789, SEQ ID NO: 791, SEQ ID NO: 792, SEQ ID NO: 793, SEQ ID NO: 794, SEQ ID NO: 795, SEQ ID NO: 796, SEQ ID NO: 805, SEQ ID NO: 806, SEQ ID NO: 814, SEQ ID NO: 829, SEQ ID NO: 833, SEQ ID NO: 839, SEQ ID NO: 840, SEQ ID NO: 849, SEQ ID NO: 850, SEQ ID NO: 851, SEQ ID NO: 852, SEQ ID NO: 853, SEQ ID NO: 854, SEQ ID NO: 858, SEQ ID NO: 861, SEQ ID NO: 862, SEQ ID NO: 864, SEQ ID NO: 868, SEQ ID NO: 869, SEQ ID NO: 870, SEQ ID NO: 871, SEQ ID NO: 879, SEQ ID NO: 881, SEQ ID NO: 885, SEQ ID NO: 886, SEQ ID NO: 887, SEQ ID NO: 892, SEQ ID NO: 894, SEQ ID NO: 896, SEQ ID NO: 899, SEQ ID NO: 911, SEQ ID NO: 917, SEQ ID NO: 919, SEQ ID NO: 920, SEQ ID NO: 923, SEQ ID NO: 930, SEQ ID NO: 933, SEQ ID NO: 942, SEQ ID NO: 962, SEQ ID NO: 969, SEQ ID NO: 979, SEQ ID NO: 1041, SEQ ID NO: 1044, SEQ ID NO: 1045, SEQ ID NO: 1047, SEQ ID NO: 1055, SEQ ID NO: 1056, SEQ ID NO: 1061, SEQ ID NO: 1067, SEQ ID NO: 1070, SEQ ID NO: 1072, SEQ ID NO: 1075, and SEQ ID NO: 1080.

95. The purified polypeptide of claim 94, wherein said H. pylori secreted polypeptide or a fragment thereof is an H pylori polypeptide involved in secretion and adhesion or a fragment thereof selected from the group consisting of SEQ ID NO: 846 and SEQ ID NO: 1060.

96. A purified H. pylori cytoplasmic polypeptide or a fragment thereof, wherein said polypeptide is selected from the group consisting of SEQ ID NO: 961 , SEQ ID NO: 1087, SEQ ID NO: 848, SEQ ID NO: 948, SEQ ID NO: 952, SEQ ID NO: 1084, SEQ ID NO: 836, SEQ ID NO: 874, SEQ ID NO: 878, SEQ ID NO: 946, SEQ ID NO: 1057, SEQ ID NO: 842, SEQ ID NO: 907, SEQ ID NO: 769, SEQ ID NO: 826, SEQ ID NO: 837, SEQ ID NO: 841, SEQ ID NO: 910, SEQ ID NO: 951, SEQ ID NO: 963, SEQ ID NO: 1054, SEQ ID NO: 1058, SEQ ID NO: 1074, SEQ ID NO: 1296, SEQ ID NO: 809, SEQ ID NO: 813, SEQ ID NO: 815, SEQ ID NO: 821, SEQ ID NO: 838, SEQ ID NO: 931, SEQ ID NO: 937, SEQ ID NO: 955, SEQ ID NO: 981, SEQ ID NO: 982, SEQ ID NO: 1049, SEQ ID NO: 1051, SEQ ID NO: 1059, and SEQ ID NO: 1082.

97. The purified polypeptide of claim 96, wherein said H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide involved in energy conversion or a fragment thereof selected from the group consisting of SEQ ID NO: 961 and SEQ ID NO: 1087.

98. The purified polypeptide of claim 96, wherein said H pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide involved in amino acid metabolism and transport or a fragment thereof selected from the group consisting of SEQ ID NO: 848 and SEQ ID NO: 948.

99. The purified polypeptide of claim 96, wherein said H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide involved in nucleotide metabolism and transport or a fragment thereof selected from the group consisting of SEQ ID NO: 952 and SEQ ID NO: 1084.

100. The purified polypeptide of claim 96, wherein said H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide involved in cofactor metabolism or a fragment thereof selected from the group consisting of SEQ ID NO: 836, SEQ ID NO: 874, SEQ ID NO: 878, SEQ ID NO: 946, and SEQ ID NO: 1057.

101. The purified polypeptide of claim 96, wherein said H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide involved in lipid metabolism or a fragment thereof selected from the group consisting of SEQ ID NO: 842 and SEQ ID NO: 907.

102. The purified polypeptide of claim 96, wherein said H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide involved in genome replication, transcription, recombination and repair or a fragment thereof selected from the group consisting of SEQ ID NO: 769, SEQ ID NO: 826, SEQ ID NO: 837, SEQ ID NO: 841, SEQ ID NO: 910, SEQ ID NO: 951, SEQ ID NO: 963, SEQ ID NO: 1054, SEQ ID NO: 1058, SEQ ID NO: 1074, and SEQ ID NO: 1296.

103. A vaccine composition for prevention or treatment of an H. pylori infection comprising an effective amount of an H. pylori polypeptide of claim 80.

104. A vaccine composition of claim 103, further comprising a pharmaceutically acceptable carrier.

105. A vaccine composition of claim 104, wherein the pharmaceutically acceptable carrier is an adjuvant.

106. A method of treating a subject for H. pylori infection comprising administering to a subject a vaccine composition of claim 103, such that treatment ofH. pylori infection occurs.

107. A method of claim 106, wherein the treatment is a prophylactic treatment.

108. A method of claim 106, wherein the treatment is a therapeutic treatment.

109. A vaccine composition for prevention or treatment of an H. pylori infection comprising an effective amount of an H. pylori polypeptide of claim 93.

110. A vaccine composition of claim 109, further comprising a pharmaceutically acceptable carrier.

111. A vaccine composition of claim 110, wherein the pharmaceutically acceptable carrier is an adjuvant.

112. A method of treating a subject for H. pylori infection comprising administering to a subject a vaccine composition of claim 109, such that treatment ofH. pylori infection occurs.

113. A method of claim 112, wherein the treatment is a prophylactic treatment.

114. A method of claim 112, wherein the treatment is a therapeutic treatment.

115. A vaccine composition for prevention or treatment of an H. pylori infection comprising an effective amount of an H. pylori polypeptide of claim 94.

116. A vaccine composition of claim 115, further comprising a pharmaceutically acceptable carrier.

117. A vaccine composition of claim 116, wherein the pharmaceutically acceptable carrier is an adjuvant.

118. A method of treating a subject for H. pylori infection comprising administering to a subject a vaccine composition of claim 115, such that treatment ofH. pylori infection occurs.

119. A method of claim 118, wherein the treatment is a prophylactic treatment.

120. A method of claim 118, wherein the treatment is a therapeutic treatment.

121. A vaccine composition for prevention or treatment of an H. pylori infection comprising an effective amount of an H. pylori polypeptide of claim 96.

122. A vaccine composition of claim 121, further comprising a pharmaceutically acceptable carrier.

123. A vaccine composition of claim 122, wherein the pharmaceutically acceptable carrier is an adjuvant.

124. A method of treating a subject for H. pylori infection comprising administering to a subject a vaccine composition of claim 121, such that treatment ofH. pylori infection occurs.

125. A method of claim 124, wherein the treatment is a prophylactic treatment.

126. A method of claim 124, wherein the treatment is a therapeutic treatment.

127. A method for detecting the presence of a Helicobacter nucleic acid in a sample comprising:

(a) contacting a sample with a nucleic acid of claim 21 under conditions in which a hybrid can form between the probe and a Helicobacter nucleic acid in the sample; and

(b) detecting the hybrid formed in step (a), wherein detection of a hybrid indicates the presence of a Helicobacter nucleic acid in the sample.

128. A method for detecting the presence of a Helicobacter nucleic acid in a sample comprising:

(a) contacting a sample with a nucleic acid of claim 37 under conditions in which a hybrid can form between the probe and a Helicobacter nucleic acid in the sample; and

(b) detecting the hybrid formed in step (a), wherein detection of a hybrid indicates the presence of a Helicobacter nucleic acid in the sample.

129. A method for detecting the presence of a Helicobacter nucleic acid in a sample comprising: .

(a) contacting a sample with a nucleic acid of claim 42 under conditions in which a hybrid can form between the probe and a Helicobacter nucleic acid in the sample; and

(b) detecting the hybrid formed in step (a), wherein detection of a hybrid indicates the presence of a Helicobacter nucleic acid in the sample.

130. A method for detecting the presence of a Helicobacter nucleic acid in a sample comprising:

(a) contacting a sample with a nucleic acid of claim 52 under conditions in which a hybrid can form between the probe and a Helicobacter nucleic acid in the sample; and

(b) detecting the hybrid formed in step (a), wherein detection of a hybrid indicates the presence of a Helicobacter nucleic acid in the sample.