AU3796099A - Assays using nucleic acid and amino acid sequences relating to helicobacter pylori - Google Patents

Assays using nucleic acid and amino acid sequences relating to helicobacter pylori Download PDF

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AU3796099A
AU3796099A AU37960/99A AU3796099A AU3796099A AU 3796099 A AU3796099 A AU 3796099A AU 37960/99 A AU37960/99 A AU 37960/99A AU 3796099 A AU3796099 A AU 3796099A AU 3796099 A AU3796099 A AU 3796099A
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Australia
Prior art keywords
seq
pylori
polypeptide
sequence
nucleic acid
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AU37960/99A
Inventor
O. Thomas Berglindh
Bjorn L. Mellgard
Douglas Smith
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AstraZeneca AB
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Astra AB
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Priority claimed from AU63278/96A external-priority patent/AU710880C/en
Application filed by Astra AB filed Critical Astra AB
Priority to AU37960/99A priority Critical patent/AU3796099A/en
Publication of AU3796099A publication Critical patent/AU3796099A/en
Abandoned legal-status Critical Current

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AUSTRALIA
PATENTS ACT 1990 REGULATION 3.2 HX 1484-2P AU Name of Applicant: Actual Inventor/s: Address for Service: ASTRA AKTIEBOLAG DOUGLAS
SMITH,
O. THOMAS BERGLINDH and BJORN L. MELLGARD.
E.F. WELLINGTON
CO.,
Patent and Trade Mark Attorneys, 312 St. Kilda Road, Melbourne, Southbank, Victoria, 3006.
Invention Title: ASSAYS USING NUCLEIC ACID AND AMINO ACID SEQUENCES RELATING TO HELICOBACTER
PYLORI"
Details of Associated Provisional Applications Nos: The following statement is a full description of this invention including the best method of performing it known to us.
1
I
ASSAYS USING NUCLEIC ACID AND AMINO ACID SEQUENCES RELATING TO HELICOBACTER PYLORI Background of the Invention Helicobacter pylori is a gram-negative. S-shaped, microaerophilic bacterium that was discovered and cultured from a human gastric biopsy specimen. (Warren. J.R. and B.
Marshall, (1983) Lancet 1: 1273-1275; and Marshall et al.. (1984) Microbios Lett. 25: 83- 88). H. pylori has been strongly linked to chronic gastritis and duodenal ulcer disease.
(Rathbone et. al., (1986) Gut 27: 635-641). Moreover, evidence is accumulating for an etiologic role of H. pylori in nonulcer dyspepsia, gastric ulcer disease, and gastric adenocarcinoma. (Blaser M. (1993) Trends Microbiol. 1: 255-260). Transmission of the bacteria occurs via the oral route, and the risk of infection increases with age. (Taylor.
D.N. and M. J. Blaser. (1991) Epidemiol. Rev 1H: 42-50). H. pylori colonizes the human gastric mucosa. establishing an infection that usually persists for decades. Infection by H.
pylori is prevalent worldwide. Developed countries have infection rates over 50% of the adult population, while developing countries have infection rates reaching 90% of the adults over the age of 20. (Hopkins R. J. and J. G. Morris (1994) Am. J. Med. 97: 265-277).
The bacterial factors necessary for colonization of the gastric environment, and for virulence of this pathogen, are poorly understood. Examples of the putative virulence 20 factors include the following: urease. an enzyme that may play a role in neutralizing gastric acid pH (Eaton et al., (1991) Infect. Immunol. 59: 2470-2475; Ferrero, R.L. and A. Lee (1991) Microb. Ecol. Hllh. Dis. 4: 121-134; Labigne et al.. (1991)]. Bacteriol. 173: 1920- 1931); the bacterial flagellar proteins responsible for motility across the mucous layer.
(Hazell et al.. (1986) J. Inf Dis. 153: 658-663; Leying et al., (1992) Mol. Microbiol. 6: 25 2863-2874: and Haas et al.. (1993) Mol. Microbiol. 8: 753-760); Vac A. a bacterial toxin that induces the formation of intracellular vacuoles in epithelial cells (Schmitt. W. and R.
Haas, (1994) Molecular Microbiol. 12(2): 307-319); and several gastric tissue-specific adhesins. (Boren et al.. (1993) Science 262: 1892-1895: Evans et al., (1993) J. Bacteriol.
175: 674-683; and Falk et al.. (1993) Proc. Natl. Acad. Sci. USA 90: 2035-203).
Numerous therapeutic agents are currently available that eradicate H. pylori infections in vitro. (Huesca et. al., (1993) Zbl. Bakt. 280: 244-252; Hopkins. R. J. and J. G.
Morris. supra). However, many of these treatments are suboptimally effective in vivo because of bacterial resistance, altered drug distribution, patient non-compliance or poor drug availabilty. (Hopkins. R. J. and J. G. Morris, supra). Treatment with antibiotics combined with bismuth are part of the standard regime used to treat H. pylori infection.
(Malfertheiner, P. and J. E. Dominguez-Munoz (1993) Clinical Therapeutics 15 Supp. B: 37-48). Recently, combinations of a proton pump inhibitors and a single antibiotic have been shown to ameliorate duodenal ulcer disease. (Malfertheiner. P. and J. E. Dominguez- Munoz supra). However, methods employing antibiotic agents can have the problem of the emergence of bacterial strains which are resistant to these agents. (Hopkins, R. J. and J. G.
Morris, supra). These limitations demonstrate that new more effective methods are needed to combat H. pylori infections in vivo. In particular, the design of new vaccines that may prevent infection by this bacterium is highly desirable.
Summary of the Invention In a first aspect, the present invention provides a drug screening assay comprising the step of contacting a test compound with a purified polypeptide comprising an amino acid sequence that is at least 60% homologous to an amino acid sequence shown in the sequence listing set out hereinafter.
In a second aspect, the present invention provides a drug screening assay comprising the step of contacting a test compound with an isolated nucleic acid comprising a nucleotide sequence that is at least 60% homologous to a nucleotide sequence shown in the 15 sequence listing set out hereinafter.
In preferred embodiments of the first aspect of the invention, the assay is characterized in that: the assay comprises determining if the compound binds to said amino acid sequence of the purified polypeptide; or *o 20 the assay comprises determining if the test compound alters the binding affinity of said amino acid sequence of the purified 00 polypeptide for a ligand thereof; or the ability of the test compound to inhibit the binding ability of said amino acid sequence to the ligand is determined; or the polypeptide has enzyme activity, and the assay comprises detecting if the test compound changes the enzymatic activity, more preferably the enzymatic activity produces a detectable reaction product with distinctive absorption, fluorescence or chemiluminescence properties; or the assay is a cell-free assay; or the amino acid sequence comprised by the purified polypeptide is at least 70%, 80%, 90%, 95%, 98% or 99% homologous to an amino acid sequence shown in the sequence listing, or identical to an amino acid sequence shown in the sequence listing.
In preferred embodiments of the second aspect of the invention, the assay is characterized in that: the assay comprises determining if the compound binds to, or interacts with, said nucleotide sequence of the nucleic acid; or *the assay is an in vitro assay; or .o the nucleotide sequence comprised by the nucleic acid is at least :15 70%, 80%, 90%, 95%, 98% or 99% homologous to a nucleotide sequence ae shown in the sequence listing, or identical to a nucleotide sequence shown in the sequence listing.
Other objects and features of the present invention, will be in part apparent and in part pointed out hereinafter in referring to the description of the parent invention, that is, the invention of Australian Patent Application No. 63278/96, which parent invention is hereinafter referred to as the invention or this invention.
This invention relates to novel genes, genes encoding polypeptides such as bacterial surface proteins, from the organism Helicobacter pylori pylori), and other related genes, their products, and uses thereof. The nucleic acids and peptides of the present invention have utility for diagnostic and therapeutics for H. pylori and other Helicobacter species. They can also be used to detect the presence ofH. pylori and other Helicobacter species in a sample; and for use in screening compounds for the ability to interfere with the H. pylori life cycle or to inhibit H pylori infection. More specifically, this invention features compositions of nucleic acids corresponding to entire coding sequences of H. pylori proteins, including surface or secreted proteins or parts thereof, nucleic acids capable of binding mRNA from H. pylori proteins to block protein translation. and methods for producing H. pylori proteins or parts thereof using peptide synthesis and recombinant DNA techniques. This invention also features antibodies and nucleic acids useful as probes to detect H. pylori infection. In addition. vaccine compositions and methods for the protection or treatment of infection by H. pylori are within the scope of this invention.
*e* Detailed Description of the Drawings Figure 1 is a bar graph that depicts the antibody titer in serum of mice following immunization with specific H. pylori antigens.
Figure 2 is a bar graph that depicts the antibody titer in mucous of mice following 20 immunization with specific H. pylori antigens.
9* *9 Figure 3 is a bar graph that depicts therapeutic immunization of H. pylori infected mice with specific antigens dissolved in HEPES buffer.
Figure 4 is a bar graph that depicts therapeutic immunization of H. pylori infected S: mice with specific antigens dissolved in buffer containing DOC.
Detailed Description of the Invention In one aspect the invention features a recombinant or substantially pure preparation of H pylori polypeptide of SEQ ID NO: 384. The invention also includes substantially pure nucleic acid encoding an H. pylori polypeptide of SEQ ID NO: 384. such nucleic acid I
I
is contained in SEQ ID NO: 1. The H. pylori polypeptide sequences of the invention described herein are contained in the Sequence Listing, and the nucleic acids encoding H.
pylori polypeptides of the invention are contained in the Sequence Listing.
In another aspect, the invention features a recombinant or substantially pure preparation of an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 384 through SEQ ID NO: 389, SEQ ID NO: 391 through SEQ ID NO: 400, SEQ ID NO: 402 through SEQ ID NO: 406, SEQ ID NO: 408, SEQ ID NO: 411 through SEQ ID NO: 412, SEQ ID NO: 414 through SEQ ID NO: 430, SEQ ID NO: 432 through SEQ ID NO: 434, SEQ ID NO: 436 through SEQ ID NO: 441, and SEQ ID NO: 443. The invention also includes substantially pure nucleic acid encoding an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides SEQ ID NO: 384 through SEQ ID NO: 389, SEQ ID NO: 391 through SEQ ID NO: 400, SEQ ID NO: 402 through SEQ ID NO: 406. SEQ ID NO: 408. SEQ ID NO: 411 through SEQ ID NO: 412, SEQ ID NO: 414 through SEQ ID NO: 430, SEQ ID NO: 432 through SEQ ID NO: 434, SEQ ID NO: 436 through SEQ ID NO: 441, and SEQ ID NO: 443, such nucleic acids are contained in SEQ ID NO: 1 through SEQ ID NO: In another aspect, the invention features a recombinant or substantially pure preparation of an H. pylori polypeptide selected from the group consisting of H. pylori S* polypeptides of SEQ ID NO: 444, SEQ ID NO: 446 through SEQ ID NO: 448, SEQ ID 20 NO: 450 through SEQ ID NO: 462, SEQ ID NO: 465 through SEQ ID NO: 466, SEQ ID S* NO: 468 through SEQ ID NO: 469, SEQ ID NO: 471 through SEQ ID NO: 473, SEQ ID NO: 475, SEQ ID NO: 478 through SEQ ID NO: 479, SEQ ID NO: 481 through SEQ ID NO: 484, SEQ ID NO: 486, SEQ ID NO: 488 through SEQ ID NO: 501, and SEQ ID NO: 503 through SEQ ID NO: 506. The invention also includes substantially pure nucleic acid encoding an H pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 444, SEQ ID NO: 446 through SEQ ID NO: 448. SEQ ID NO: 450 through SEQ ID NO: 462, SEQ ID NO: 465 through SEQ ID NO: 466, SEQ ID NO: 468 through SEQ ID NO: 469. SEQ ID NO: 471 through SEQ ID NO: 473, SEQ ID NO: 475, SEQ ID NO: 478 through SEQ ID NO: 479, SEQ ID NO: 481 through SEQ ID NO: 484, SEQ ID NO: 486. SEQ ID NO: 488 through SEQ ID NO: 501, and SEQ ID NO: 503 through SEQ ID NO: 506. such nucleic acids are contained in SEQ ID NO: 51 through SEQ ID NO: 100.
In another aspect. the invention features a recombinant or substantially pure preparation of an H pylori polypeptide selected from the group consisting of H pylori polypeptides of SEQ ID NO: 509 through SEQ ID NO: 510. SEQ ID NO: 512 through SEQ ID NO: 514, SEQ ID NO: 516. SEQ ID NO: 518 through SEQ ID NO: 520, SEQ ID NO: 522 through SEQ ID NO: 525. SEQ ID NO: 527 through SEQ ID NO: 533, SEQ ID NO: 535 through SEQ ID NO: 537, SEQ ID NO: 539 through SEQ ID NO: 540, SEQ ID NO: 542 through SEQ ID NO: 544, SEQ ID NO: 546 through SEQ ID NO: 548, SEQ ID NO: 550, SEQ ID NO: 553 through SEQ ID NO: 556, SEQ ID NO: 558, SEQ ID NO: 560, SEQ ID NO: 562 through SEQ ID NO: 568, SEQ ID NO: 570, and SEQ ID NO: 572 through SEQ ID NO: 575. The invention also includes substantially pure nucleic acid encoding an H pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 509 through SEQ ID NO: 510, SEQ ID NO: 512 through SEQ ID NO: 514, SEQ ID NO: 516. SEQ ID NO: 518 through SEQ ID NO: 520, SEQ ID NO: 522 through SEQ ID NO: 525, SEQ ID NO: 527 through SEQ ID NO: 533, SEQ ID NO: 535 through SEQ ID NO: 537, SEQ ID NO: 539 through SEQ ID NO: 540, SEQ ID NO: 542 through SEQ ID NO: 544, SEQ ID NO: 546 through SEQ ID NO: 548, SEQ ID NO: 550, SEQ ID NO: 553 through SEQ ID NO: 556, SEQ ID NO: 558, SEQ ID NO: 560, SEQ ID NO: 562 through SEQ ID NO: 568, SEQ ID NO: 570, and SEQ ID NO: 572 through SEQ ID NO: 575, such nucleic acids are contained in SEQ ID NO: 101 through SEQ ID NO: 150.
In another aspect, the invention features a recombinant or substantially pure preparation of an H. pylori polypeptide selected from the group consisting of H pylori polypeptides of SEQ ID NO: 576 through SEQ ID NO: 579, SEQ ID NO: 581 through SEQ ID NO: 583, SEQ ID NO: 585 through SEQ ID NO: 593, SEQ ID NO: 596 through SEQ ID NO: 614. SEQ ID NO: 617 through SEQ ID NO: 623, SEQ ID NO: 625, SEQ ID NO: 627, SEQ ID NO: 629 through SEQ ID NO: 631, SEQ ID NO: 633, and SEQ ID NO: 635 through SEQ ID NO: 636. The invention also includes substantially pure nucleic acid 20 encoding an H. pylori polypeptide selected from the group consisting of H pylori polypeptides of SEQ ID NO: 576 through SEQ ID NO: 579, SEQ ID NO: 581 through SEQ ID NO: 583, SEQ ID NO: 585 through SEQ ID NO: 593, SEQ ID NO: 596 through
SEQ
ID NO: 614, SEQ ID NO: 617 through SEQ ID NO: 623, SEQ ID NO: 625, SEQ ID NO: 627. SEQ ID NO: 629 through SEQ ID NO: 631, SEQ ID NO: 633, and SEQ ID NO: 635 through SEQ ID NO: 636. such nucleic acids are contained in SEQ ID NO: 151 through SEQ ID NO: 200.
In another aspect, the invention features a recombinant or substantially pure preparation of an H. pylori polypeptide selected from the group consisting of H pylori polypeptides of SEQ ID NO: 638 through SEQ ID NO: 640, SEQ ID NO: 642 through SEQ ID NO: 643, SEQ ID NO: 647, SEQ ID NO: 649 through SEQ ID NO: 651, SEQ ID NO: 653 through SEQ ID NO: 661, SEQ ID NO: 663 through SEQ ID NO: 670, SEQ ID NO: 673 through SEQ ID NO:674, SEQ ID NO: 676, SEQ ID NO: 678 through SEQ ID NO: 683, SEQ ID NO: 687 through SEQ ID NO: 692. and SEQ ID NO: 694 through SEQ ID NO: 702. The invention also includes substantially pure nucleic acid encoding an H. pylori polypeptide selected from the group consisting ofH. pylori polypeptides of SEQ ID NO: 638 through SEQ ID NO: 640, SEQ ID NO: 642 through SEQ ID NO: 643, SEQ ID NO: 647, SEQ ID NO: 649 through SEQ ID NO: 651, SEQ ID NO: 653 through SEQ ID NO: 661. SEQ ID NO: 663 through SEQ ID NO: 670, SEQ ID NO: 673 through SEQ ID NO: 674, SEQ ID NO: C76, SEQ ID NO: 678 through SEQ ID NO: 683, SEQ ID NO: 687 through SEQ ID NO: 692. and SEQ ID NO: 694 through SEQ ID NO: 702, such nucleic acids are contained in SEQ ID NO: 201 through SEQ ID NO: 250.
In another aspect, the invention features a recombinant or substantially pure preparation of an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 705 through SEQ ID NO: 708, SEQ ID NO: 712 through SEQ ID NO: 714, SEQ ID NO: 716 through SEQ ID NO: 722. SEQ ID NO: 725 through SEQ ID NO: 730, SEQ ID NO: 732 through SEQ ID NO: 733. SEQ ID NO: 735 through SEQ ID NO: 744, SEQ ID NO: 746 through SEQ ID NO: 752. SEQ ID NO: 755 through SEQ ID NO: 757, SEQ ID NO: 759, SEQ ID NO: 761 through SEQ ID NO: 763, and SEQ ID NO: 767 through SEQ ID NO: 770. The invention also includes substantially pure nucleic acid encoding an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 705 through SEQ ID NO: 708, SEQ ID NO: 712 through SEQ ID NO: 714, SEQ ID NO: 716 through SEQ ID NO: 722. SEQ ID NO: 725 through SEQ ID NO: 730, SEQ ID NO: 732 through SEQ ID NO: 733. SEQ ID NO: 735 through SEQ ID NO: 744, SEQ ID NO: 746 through SEQ ID NO: 752, SEQ ID NO: 755 through SEQ ID NO: 757, SEQ ID NO: 759, SEQ ID NO: 761 through SEQ ID NO: 763. and SEQ ID NO: 767 through SEQ ID NO: 770, such nucleic acids are contained in SEQ ID NO: 251 through SEQ ID NO: 300.
In another aspect, the invention features a recombinant or substantially pure 20 preparation of an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 771 through SEQ ID NO: 773, SEQ ID NO: 775, SEQ ID NO: 777, SEQ ID NO: 779 through SEQ ID NO: 784, SEQ ID NO: 786 through SEQ ID NO: 787, SEQ ID NO: 789 through SEQ ID NO: 792, SEQ ID NO: 794, SEQ ID NO: 796, SEQ ID NO: 798 through SEQ ID NO: 805, SEQ ID NO: 807 through SEQ ID NO: 811, SEQ ID NO: 813 through SEQ ID NO: 819, SEQ ID NO: 821 through SEQ ID NO: 822.
.SEQ ID NO: 824 through SEQ ID NO: 826, SEQ ID NO: 828 through SEQ ID NO: 832, and SEQ ID NO: 835. The invention also includes substantially pure nucleic acid encoding an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 771 through SEQ ID NO: 773, SEQ ID NO: 775, SEQ ID NO: 777, SEQ ID NO: 779 through SEQ ID NO: 784, SEQ ID NO: 786 through SEQ ID NO: 787, SEQ ID NO: 789 through SEQ ID NO: 792, SEQ ID NO: 794, SEQ ID NO: 796, SEQ ID NO: 798 through SEQ ID NO: 805, SEQ ID NO: 807 through SEQ ID NO: 811, SEQ ID NO: 813 through SEQ ID NO: 819, SEQ ID NO: 821 through SEQ ID NO: 822, SEQ ID NO: 824 through SEQ ID NO: 826. SEQ ID NO: 828 through SEQ ID NO: 832, and SEQ ID NO: 835, such nucleic acids are contained in SEQ ID NO: 301 through SEQ ID NO: 350.
In another aspect. the invention features a recombinant or substantially pure preparation of an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 836 through SEQ ID NO: 841, SEQ ID NO: 843 through SEQ ID NO: 851, SEQ ID NO: 853, SEQ ID NO: 855 through SEQ ID NO: 857, SEQ ID NO:
I
859 through SEQ ID NO: 862, SEQ ID NO: 866, SEQ ID NO: 868 through SEQ ID NO: 871, SEQ ID NO: 873 through SEQ ID NO: 876. and SEQ ID NO: 879. The invention also includes substantially pure nucleic acid encoding an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 836 through SEQ ID NO: 841, SEQ ID NO: 843 through SEQ ID NO: 851, SEQ ID NO: 853, SEQ ID NO: 855 through SEQ ID NO: 857, SEQ ID NO: 859 through SEQ ID NO: 862. SEQ ID NO: 866. SEQ ID NO: 868 through SEQ ID NO: 871, SEQ ID NO: 873 through SEQ ID NO: 876, and SEQ ID NO: 879, such nucleic acids are contained in SEQ ID NO: 351 through SEQ ID NO: 383.
In another aspect, the invention features a recombinant or substantially pure preparation of an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 385, SEQ ID NO: 390, SEQ ID NO: 401, SEQ ID NO: 407, SEQ ID NO: 409 through SEQ ID NO: 410. SEQ ID NO: 413, SEQ ID NO: 431. SEQ ID NO: 435, SEQ ID NO: 442, SEQ ID NO: 445, SEQ ID NO: 449, SEQ ID NO: 463 through SEQ ID NO: 464. SEQ ID NO: 467, SEQ ID NO: 470, SEQ ID NO: 474, SEQ ID NO: 476 through SEQ ID NO: 477, SEQ ID NO: 480. SEQ ID NO: 485, SEQ ID NO: 487, SEQ ID NO: 502, SEQ ID NO: 507 through SEQ ID NO: 508, SEQ ID NO: 511, SEQ ID NO: 515, SEQ ID NO: 517, SEQ ID NO: 521, SEQ ID NO: 526, SEQ ID NO: 534, SEQ ID NO: 538, SEQ ID NO: 541, SEQ ID NO: 545, SEQ ID NO: 549, SEQ ID NO: 551 through SEQ 20 ID NO: 552, SEQ ID NO: 557, SEQ ID NO: 559, SEQ ID NO: 561, SEQ ID NO: 569, SEQ ID NO: 571, SEQ ID NO: 580, SEQ ID NO: 584, SEQ ID NO: 594 through SEQ ID NO: 595, SEQ ID NO: 615 through SEQ ID NO: 616, SEQ ID NO: 624, and SEQ ID NO: 626. The invention also includes substantially pure nucleic acid encoding an H. pylori Spolypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 385, SEQ ID NO: 390, SEQ ID NO: 401, SEQ ID NO: 407, SEQ ID NO: 409 through SEQ 'ID NO: 410, SEQ ID NO: 413, SEQ ID NO: 431, SEQ ID NO: 435, SEQ ID NO: 442, SEQ ID NO: 445, SEQ ID NO: 449, SEQ ID NO: 463 through SEQ ID NO: 464, SEQ ID NO: 467, SEQ ID NO: 470, SEQ ID NO: 474, SEQ ID NO: 476 through SEQ ID NO: 477, SEQ ID NO: 480, SEQ ID NO: 485, SEQ ID NO: 487, SEQ ID NO: 502, SEQ ID NO: 507 through SEQ ID NO: 508, SEQ ID NO: 511, SEQ ID NO: 515, SEQ ID NO: 517, SEQ ID NO: 521, SEQ ID NO: 526, SEQ ID NO: 534, SEQ ID NO: 538, SEQ ID NO: 541, SEQ ID NO: 545, SEQ ID NO: 549, SEQ ID NO: 551 through SEQ ID NO: 552. SEQ ID NO: 557, SEQ ID NO: 559, SEQ ID NO: 561, SEQ ID NO: 569, SEQ ID NO: 571. SEQ ID NO: 580, SEQ ID NO: 584, SEQ ID NO: 594 through SEQ ID NO: 595, SEQ ID NO: 615 through SEQ ID NO: 616, SEQ ID NO: 624, and SEQ ID NO: 626, such nucleic acids are contained in SEQ ID NO: 881 through SEQ ID NO: 930.
In another aspect, the invention features a recombinant or substantially pure preparation of an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 628, SEQ ID NO: 632, SEQ ID NO: 634, SEQ ID NO: 637, SEQ ID NO: 641, SEQ ID NO: 644 through SEQ ID NO: 646, SEQ ID NO: 648, SEQ ID NO: 652, SEQ ID NO: 662. SEQ ID NO: 671 through SEQ ID NO: 672, SEQ ID NO: 675, SEQ ID NO: 677, SEQ ID NO: 684 through SEQ ID NO: 686, SEQ ID NO: 693, SEQ ID NO: 703 through SEQ ID NO: 704, SEQ ID NO: 709 through SEQ ID NO: 711. SEQ ID NO: 715. SEQ ID NO: 723 through SEQ ID NO: 724, SEQ ID NO: 731, SEQ ID NO: 734, SEQ ID NO: 745, SEQ ID NO: 753 through SEQ ID NO: 754, SEQ ID NO: 758, SEQ ID NO: 760, SEQ ID NO: 764 through SEQ ID NO: 766, SEQ ID NO: 774, SEQ ID NO: 776, SEQ ID NO: 778, SEQ ID NO: 785, SEQ ID NO: 788, SEQ ID NO: 793, SEQ ID NO: 795, SEQ ID NO: 797, SEQ ID NO: 806, SEQ ID NO: 812, SEQ ID NO: 820, SEQ ID NO: 823, and SEQ ID NO: 827. The invention also includes substantially pure nucleic acid encoding an H. pylori polypeptide selected from the group consisting ofH. pylori polypeptides of SEQ ID NO: 628, SEQ ID NO: 632, SEQ ID NO: 634, SEQ ID NO: 637, SEQ ID NO: 641, SEQ ID NO: 644 through SEQ ID NO: 646, SEQ ID NO: 648, SEQ ID NO: 652, SEQ ID NO: 662. SEQ ID NO: 671 through SEQ ID NO: 672, SEQ ID NO: 675, SEQ ID NO: 677, SEQ ID NO: 684 through SEQ ID NO: 686, SEQ ID NO: 693, SEQ ID NO: 703 through SEQ ID NO: 704, SEQ ID NO: 709 through SEQ ID NO: 711, SEQ ID NO: 715, SEQ ID NO: 723 through SEQ ID NO: 724, SEQ ID NO: 731, SEQ ID NO: 734, SEQ ID NO: 745, SEQ ID NO: 753 through SEQ ID NO: 754, SEQ ID NO: 758, SEQ ID •NO: 760, SEQ ID NO: 764 through SEQ ID NO: 766, SEQ ID NO: 774, SEQ ID NO: 776, 20 SEQ ID NO: 778, SEQ ID NO: 785, SEQ ID NO: 788, SEQ ID NO: 793, SEQ ID NO: 795, SEQ ID NO: 797, SEQ ID NO: 806, SEQ ID NO: 812, SEQ ID NO: 820, SEQ ID NO: 823, and SEQ ID NO: 827, such nucleic acids are contained in SEQ ID NO: 931 through SEQ ID NO: 980.
In another aspect, the invention features a recombinant or substantially pure preparation of an H. pylori polypeptide selected from the group consisting ofH. pylori polypeptides of SEQ ID NO: 833 through SEQ ID NO: 834, SEQ ID NO: 842, SEQ ID NO: 852, SEQ ID NO: 854, SEQ ID NO: 858, SEQ ID NO: 863, SEQ ID NO: 864 through SEQ ID NO: 865, SEQ ID NO: 867, SEQ ID NO: 872, SEQ ID NO: 877 through SEQ ID NO: 878, and SEQ ID NO: 880. The invention also includes substantially pure nucleic acid encoding an H. pylori polypeptide selected from the group consisting ofH. pylori polypeptides of SEQ ID NO: 833 through SEQ ID NO: 834, SEQ ID NO: 842, SEQ ID NO: 852, SEQ ID NO: 8-54, SEQ ID NO: 858, SEQ ID NO: 863, SEQ ID NO: 864 through SEQ ID NO: 865, SEQ ID NO: 867, SEQ ID NO: 872, SEQ ID NO: 877 through SEQ ID NO: 878, and SEQ ID NO: 880, such nucleic acids are contained in SEQ ID NO: 981 through SEQ ID NO: 994.
In another aspect, the invention features a recombinant or substantially pure preparation of an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 1446 through SEQ ID NO: 1461, SEQ ID NO: 1463, and SEQ ID NO: 1465. through SEQ ID NO: 1495. The invention also includes substantially pure nucleic acid encoding an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides SEQ ID NO: 1446 through SEQ ID NO: 1461, SEQ ID NO: 1463, and SEQ ID NO: 1465 through SEQ ID NO: 1495, such nucleic acids are contained in SEQ ID NO: 995 through SEQ ID NO: SEQ ID NO: 1010, SEQ ID NO: 1012, and SEQ ID NO: 1014 through SEQ ID NO: 1044.
In another aspect. the invention features a recombinant or substantially pure preparation of an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 1497 through SEQ ID NO: 1515, and SEQ ID NO: 1517 through SEQ ID NO: 1545. The invention also includes substantially pure nucleic acid encoding an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides SEQ ID NO: 1497 through SEQ ID NO: 1515, and SEQ ID NO: 1517 through SEQ ID NO: 1545, such nucleic acids are contained in SEQ ID NO: 1046 through SEQ ID NO: 1064, and SEQ ID NO: 1066 through SEQ ID NO: 1094.
In another aspect, the invention features a recombinant or substantially pure preparation of an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 1546 through SEQ ID NO: 1595. The invention also includes substantially pure nucleic acid encoding an H. pylori polypeptide selected from the group consisting of H pylori polypeptides SEQ ID NO: 1546 through SEQ ID NO: 1595, such nucleic acids are contained in SEQ ID NO: 1095 through SEQ ID NO: 1144.
20 In another aspect, the invention features a recombinant or substantially pure preparation of an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 1596 through SEQ ID NO: 1617, SEQ ID NO: 1620 through •9 -9 SEQ ID NO: 1645. The invention also includes substantially pure nucleic acid encoding an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides SEQ ID NO: 1596 through SEQ ID NO: 1617, SEQ ID NO: 1620 through SEQ ID NO: 1645, such *9.o nucleic acids are contained in SEQ ID NO: 1145 through SEQ ID NO: 1166, and SEQ ID NO: 1169 through SEQ ID NO: 1194.
In another aspect, the invention features a recombinant or substantially pure S" preparation of an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 1646 through SEQ ID NO: 1681, and SEQ ID NO: 1683 through SEQ ID NO: 1695. The invention also includes substantially pure nucleic acid encoding an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides SEQ ID NO: 1646 through SEQ ID NO: 1681. and SEQ ID NO: 1683 through SEQ ID NO: 1695, such nucleic acids are contained in SEQ ID NO: 1195 through SEQ ID NO: 1230, and SEQ ID NO: 1232 through SEQ ID NO: 1244.
In another aspect, the invention features a recombinant or substantially pure preparation of an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 1696 through SEQ ID NO: 1745. The invention also includes substantially pure nucleic acid encoding an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides SEQ ID NO: 1696 through SEQ ID NO: 1745, such nucleic acids are contained in SEQ ID NO: 1245 through SEQ ID NO: 1294.
In another aspect, the invention features a recombinant or substantially pure preparation of an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 1746 through SEQ ID NO: 1783, and SEQ ID NO: 1786 through SEQ ID NO: 1795. The invention also includes substantially pure nucleic acid encoding an H. pylori polypeptide selected from the group consisting ofH. pylori polypeptides SEQ ID NO: 1746 through SEQ ID NO: 1783, and SEQ ID NO: 1786 through SEQ ID NO: 1795, such nucleic acids are contained in SEQ ID NO: 1295 through SEQ ID NO: 1332, and SEQ ID NO: 1335 through SEQ ID NO: 1344.
In another aspect, the invention features a recombinant or substantially pure preparation of an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 1796 through SEQ ID NO: 1817, SEQ ID NO: 1819, SEQ ID NO: 1821. SEQ ID NO: 1823 through SEQ ID NO: 1836. and SEQ ID NO: 1838 through S 15 SEQ ID NO: 1845. The invention also includes substantially pure nucleic acid encoding an H. pylori polypeptide selected from the group consisting of H pylori polypeptides SEQ ID NO: 1796 through SEQ ID NO: 1817, SEQ ID NO: 1819, SEQ ID NO: 1821, SEQ ID NO: 1823 through SEQ ID NO: 1836, and SEQ ID NO: 1838 through SEQ ID NO: 1845, such nucleic acids are contained in SEQ ID NO: 1345 through SEQ ID NO: 1366, SEQ ID NO: S 20 1368, SEQ ID NO: 1370, SEQ ID NO: 1372 through SEQ ID NO: 1385. and SEQ ID NO: 1387 through SEQ ID NO: 1394.
In another aspect, the invention features a recombinant or substantially pure ^preparation of an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 1846 through SEQ ID NO: 1896. The invention also includes substantially pure nucleic acid encoding an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides SEQ ID NO: 1846 through SEQ ID NO: 1896, such nucleic acids are contained in SEQ ID NO: 1395 through SEQ ID NO: 1445.
In another aspect, the invention features a recombinant or substantially pure preparation of an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides of the invention as set forth in the Sequence Listing. The invention also includes substantially pure nucleic acid encoding an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides of the invention as set forth in the Sequence Listing. It should be understood that this invention encompasses each of the H. pylori polypeptides and nucleic acids encoding such polypeptides as identified in the Sequence Listing by a given sequence identification number. For example, a representative H. pylori polypeptide is contained in SEQ ID NO: 1450. Therefore, this invention encompasses a recombinant or substantially pure preparation of an H. pylori polypeptide of SEQ ID NO: 1450. The invention also includes substantially pure nucleic acid encoding an H. pylori polypeptide of SEQ ID NO: 1450.
In another aspect, the invention pertains to any individual H. pylori polypeptide member or nucleic acid encoding such member from the above-identified groups ofH.
pylori polypeptides SEQ ID NO: 1546 through SEQ ID NO: 1595) or nucleic acids SEQ ID NO: 1095-SEQ ID NO: 1144), as well as any subgroups from within the above-identified groups. Furthermore, the subgroups can preferably consists of 1, 3, 5, 20. 30 or 40 members of any of the groups identified above, as well as any combinations thereof. For example, the group consisting of H. pylori polypeptides SEQ ID NO: 1846 through SEQ ID NO: 1896 can be divided into one or more subgroups as follows: SEQ ID NO: 1846-SEQ ID NO: 1860; SEQ ID NO: 1861-SEQ ID NO: 1875; SEQ ID NO: 1876-SEQ ID NO: 1885; SEQ ID NO: 1886-SEQ ID NO: 1896; or any combinations thereof.
Particularly perferred is an isolated nucleic acid comprising a nucleotide sequence encoding an H. pylori cell envelope polypeptide or a fragment thereof. Such nucleic acid is selected from the group consisting of SEQ ID NO: 1020, SEQ ID NO: 1021, SEQ ID NO: 15 1036. SEQ ID NO: 1050, SEQ ID NO: 1071, SEQ ID NO: 1101. SEQ ID NO: 1135. SEQ SID NO: 1276, SEQ ID NO: 1150, SEQ ID NO: 1187, SEQ ID NO: 1192, SEQ ID NO: 1361, SEQ ID NO: 1379. SEQ ID NO: 1399, SEQ ID NO: 1403, SEQ ID NO: 1400. SEQ SID NO: 1189, SEQ ID NO: 1002, SEQ ID NO: 1213, SEQ ID NO: 1214, SEQ ID NO: 1215, SEQ ID NO: 1234, SEQ ID NO: 1236, SEQ ID NO: 1237, SEQ ID NO: 1224. SEQ 20 ID NO: 1251, SEQ ID NO: 1262, SEQ ID NO: 1149, SEQ ID NO: 1220, SEQ ID NO: 1240, SEQ ID NO: 1164, SEQ ID NO: 1165, SEQ ID NO: 1404, SEQ ID NO: 1144, SEQ ID NO: 1182, SEQ ID NO: 1157, SEQ ID NO: 1160, SEQ ID NO: 1300, SEQ ID NO: 1321, SEQ ID NO: 1323. SEQ ID NO: 1329, SEQ ID NO: 1332, SEQ ID NO: 1345, SEQ ID NO: 1358, SEQ ID NO: 1375. SEQ ID NO: 1417. SEQ ID NO: 1283. SEQ ID NO: 25 1335, SEQ ID NO: 1368. SEQ ID NO: 1179, SEQ ID NO: 1255, SEQ ID NO: 1258, SEQ ID NO: 1044, SEQ ID NO: 1273, SEQ ID NO: 1219, SEQ ID NO: 1274, SEQ ID NO: 1210. SEQ ID NO: 1422. SEQ ID NO: 1302, SEQ ID NO: 1308, SEQ ID NO: 1310, SEQ ID NO: 1331, SEQ ID NO: 1432. SEQ ID NO: 1052, SEQ ID NO: 1091, SEQ ID NO: 1421, SEQ ID NO: 1069. SEQ ID NO: 1005, SEQ ID NO: 1007, SEQ ID NO: 1166. SEQ ID NO: 1177, SEQ ID NO: 1193. SEQ ID NO: 1206, SEQ ID NO: 1207, SEQ ID NO: 1304, SEQ ID NO: 1305. SEQ ID NO: 1346, SEQ ID NO: 1348, SEQ ID NO: 1350, SEQ ID NO: 1032, SEQ ID NO: 1053. SEQ ID NO: 1081. SEQ ID NO: 1124, SEQ ID NO: 1382, SEQ ID NO: 1437. SEQ ID NO: 1263, SEQ ID NO: 1173, SEQ ID NO: 1405. SEQ ID NO: 1406, SEQ ID NO: 1410. SEQ ID NO: 1086, SEQ ID NO: 1322, SEQ ID NO: 1266, SEQ ID NO: 1282. SEQ ID NO: 1271, SEQ ID NO: 1208, SEQ ID NO: 1126, SEQ ID NO: 1270, SEQ ID NO: 1278. SEQ ID NO: 1419, SEQ ID NO: 1125, SEQ ID NO: 1181, SEQ ID NO: 1416. SEQ ID NO: 1096, SEQ ID NO: 1082, SEQ ID NO: 1146, SEQ ID NO: 1145, SEQ ID NO: 1108. SEQ ID NO: 1148, SEQ ID NO: 1337, SEQ ID NO: 1338. SEQ ID NO: 1424. SEQ ID NO: 1000. SEQ ID NO: 1027. SEQ ID NO: 1175, SEQ ID NO: 1330, SEQ ID NO: 217, SEQ ID NO: 217, SEQ ID NO: 367, SEQ ID NO: 911,SEQ ID NO: 944. SEQ ID NO: 18. SEQ ID NO: 107, SEQ ID NO: 894. SEQ ID NO: 943, SEQ ID NO: 203, SEQ ID NO: 85. SEQ ID NO: 290, SEQ ID NO: 5. SEQ ID NO: 199, SEQ ID NO: 992, SEQ ID NO: 934, SEQ ID NO: 899, SEQ ID NO: 302, SEQ ID NO: 215, SEQ ID NO: 893, SEQ ID NO: 984, SEQ ID NO: 97,SEQ ID NO: 22. SEQ ID NO: 49, SEQ ID NO: 309, SEQ ID NO: 150, SEQ ID NO: 240, SEQ ID NO: 957, SEQ ID NO: 57. SEQ ID NO: 2, SEQ ID NO: 92, SEQ ID NO: 255, SEQ ID NO: 164, SEQ ID NO: 201, SEQ ID NO: 278, SEQ ID NO: 245, SEQ ID NO: 921, SEQ ID NO: 896, SEQ ID NO: 248, SEQ ID NO: 159, SEQ ID NO: 979, SEQ ID NO: 194, SEQ ID NO: 194, SEQ ID NO: 946, SEQ ID NO: 916, SEQ ID NO: 76, SEQ ID NO: 905, SEQ ID NO: 914, SEQ ID NO: 931, SEQ ID NO: 50, SEQ ID NO: 250, SEQ ID NO: 969, SEQ ID NO: 66,SEQ ID NO: 275, SEQ ID NO: 330, SEQ ID NO: 204, SEQ ID NO: 383, SEQ ID NO: 303, SEQ ID NO: 70, SEQ ID NO: 983, SEQ ID NO: 972, SEQ ID NO: 929, SEQ ID NO: 972, SEQ ID NO: 936, SEQ ID NO: 267. SEQ ID NO: 197, SEQ ID NO: 55, SEQ ID NO: 54, 15 SEQ ID NO: 210, SEQ ID NO: 90, SEQ ID NO: 15. SEQ ID NO: 913, SEQ ID NO: 227, SEQ ID NO: 79, SEQ ID NO: 191, SEQ ID NO: 238, SEQ ID NO: 274, SEQ ID NO: 27, SEQ ID NO: 258. SEQ ID NO: 295, SEQ ID NO: 10, SEQ ID NO: 160, SEQ ID NO: 225, SSEQ ID NO: 964, SEQ ID NO: 166, SEQ ID NO: 56, SEQ ID NO: 980,SEQ ID NO: 903, SEQ ID NO: 261, SEQ ID NO: 71, SEQ ID NO: 955, SEQ ID NO: 361, SEQ ID NO: 58, 20 SEQ ID NO: 114, SEQ ID NO: 940, SEQ ID NO: 960. SEQ ID NO: 144, SEQ ID NO: *362. SEQ ID NO: 40, SEQ ID NO: 285, SEQ ID NO: 11, SEQ ID NO: 161. SEQ ID NO: 974, SEQ ID NO: 111, SEQ ID NO: 316, SEQ ID NO: 257, SEQ ID NO: 78, SEQ ID NO: 966, SEQ ID NO: 352, SEQ ID NO: 981, SEQ ID NO: 158, SEQ ID NO: 989, SEQ ID NO: 963, SEQ ID NO: 48, SEQ ID NO: 68, SEQ ID NO: 135, SEQ ID NO: 910, SEQ ID NO: 236, SEQ ID NO: 241, SEQ ID NO: 949, SEQ ID NO: 945, SEQ ID NO: 207, SEQ ID NO: 977, SEQ ID NO: 978, SEQ ID NO: 994, SEQ ID NO: 163, SEQ ID NO: 256, SEQ ID NO: 287, SEQ ID NO: 184, SEQ ID NO: 45, SEQ ID NO: 136, SEQ ID NO: 214, SEQ ID NO: 16, SEQ ID NO: 192, SEQ ID NO: 373, SEQ ID NO: 892, SEQ ID NO: 239, SEQ ID NO: 34, SEQ ID NO: 340, SEQ ID NO: 41, SEQ ID NO: 332, SEQ ID NO: 134, and SEQ ID NO: 330.
In one embodiment, the H. pylori cell envelope polypeptide or a fragment thereof is an H. pylori flagella-associated polypeptide or a fragment thereof encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 1020, SEQ ID NO: 1021, SEQ ID NO: 1036, SEQ ID NO: 1050, SEQ ID NO: 1071, SEQ ID NO: 1101, SEQ ID NO: 1135, SEQ ID NO: 1276, SEQ ID NO: 1150. SEQ ID NO: 1187, SEQ ID NO: 1192. SEQ ID NO: 1361, SEQ ID NO: 1379, SEQ ID NO: 1399, SEQ ID NO: 1403, SEQ ID NO: 1400, SEQ ID NO: 1189, SEQ ID NO: 217, SEQ ID NO: 367, SEQ ID NO: 911,SEQ ID NO: 944, SEQ ID NO: 18, SEQ ID NO: 107, SEQ ID NO: 894, SEQ ID NO: 943, SEQ ID NO: -12- 203, SEQ ID NO: 85, SEQ ID NO: 290. SEQ ID NO: 5, SEQ ID NO: 199. SEQ ID NO: 992. SEQ ID NO: 934, SEQ ID NO: 899, SEQ ID NO: 302, and SEQ ID NO: 215.
In another embodiment, the H. pylori cell envelope polypeptide or a fragment thereof is an H. pylori inner membrane polypeptide or a fragment thereof encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 1002, SEQ ID NO: 1213, SEQ ID NO: 1214, SEQ ID NO: 1215, SEQ ID NO: 1234, SEQ ID NO: 1236, SEQ ID NO: 1237, SEQ ID NO: 1224, SEQ ID NO: 1251, SEQ ID NO: 1262, SEQ ID NO: 1149, SEQ ID NO: 1220, SEQ ID NO: 1240, SEQ ID NO: 1164, SEQ ID NO: 1165. SEQ ID NO: 1404, SEQ ID NO: 1144, SEQ ID NO: 1182, SEQ ID NO: 1157, SEQ ID NO: 1160, SEQ ID NO: 1300, SEQ ID NO: 1321, SEQ ID NO: 1323, SEQ ID NO: 1329, SEQ ID NO: 1332. SEQ ID NO: 1345, SEQ ID NO: 1358, SEQ ID NO: 1375, SEQ ID NO: 1417, SEQ ID NO: 1283, SEQ ID NO: 1335, SEQ ID NO: 1368, SEQ ID NO: 1179, SEQ ID NO: 1255, SEQ ID NO: 1258. SEQ ID NO: 1044, SEQ ID NO: 1273. SEQ ID NO: 893, SEQ ID NO: 984, SEQ ID NO: 97.SEQ ID NO: 22, SEQ ID NO: 49. SEQ ID NO: 309, 15 SEQ ID NO: 150, SEQ ID NO: 240, SEQ ID NO: 957, SEQ ID NO: 57, SEQ ID NO: 2, '"SEQ ID NO: 92, SEQ ID NO: 255, SEQ ID NO: 164, SEQ ID NO: 201, SEQ ID NO: 278, SEQ ID NO: 245, SEQ ID NO: 921, SEQ ID NO: 896, SEQ ID NO: 248, SEQ ID NO: 159, SEQ ID NO: 979, SEQ ID NO: 194, SEQ ID NO: 194, SEQ ID NO: 946, SEQ ID NO: 916, SEQ ID NO: 76, SEQ ID NO: 905, SEQ ID NO: 914, SEQ ID NO: 931, SEQ ID NO: 50, SEQ ID NO: 250, SEQ ID NO: 969, SEQ ID NO: 66.SEQ ID NO: 275, SEQ ID NO: 330, SEQ ID NO: 204, SEQ ID NO: 383, SEQ ID NO: 303, SEQ ID NO: 70, SEQ ID NO: 983, SEQ ID NO: 972, SEQ ID NO: 929, SEQ ID NO: 972, SEQ ID NO: 936, SEQ ID NO: 267, SEQ ID NO: 197, SEQ ID NO: 55, SEQ ID NO: 54, and SEQ ID NO: 210.
In yet another embodiment, the H. pylori cell envelope polypeptide or a fragment thereof is an H. pylori transporter polypeptide or a fragment thereof encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 1219. SEQ ID NO: 1274, SEQ ID NO: 1210, SEQ ID NO: 1422. SEQ ID NO: 1302, SEQ ID NO: 1308, SEQ ID NO: 1310, SEQ ID NO: 1331. SEQ ID NO: 1432, SEQ ID NO: 1052, SEQ ID NO: 1091, SEQ ID NO: 1421, SEQ ID NO: 1069, SEQ ID NO: 1005, SEQ ID NO: 1007, SEQ ID NO: 1166, SEQ ID NO: 1177, SEQ ID NO: 1193, SEQ ID NO: 1206, SEQ ID NO: 1207, SEQ ID NO: 1304, SEQ ID NO: 1305, SEQ ID NO: 1346, SEQ ID NO: 1348, SEQ ID NO: 1350, SEQ ID NO: 1032, SEQID NO: 1053, SEQ ID NO: 1081, SEQ ID NO: 1124, SEQ ID NO: 1382, SEQ ID NO: 1437, SEQ ID NO: 1263, SEQ ID NO: 90, SEQ ID NO: 15, SEQ ID NO: 913, SEQ ID NO: 227, SEQ ID NO: 79, SEQ ID NO: 191, SEQ ID NO: 238, SEQ ID NO: 274, SEQ ID NO: 27. SEQ ID NO: 258, SEQ ID NO: 295, SEQ ID NO: 10. SEQ ID NO: 160, SEQ ID NO: 225, SEQ ID NO: 964, SEQ ID NO: 166, SEQ ID NO: 56, SEQ ID NO: 980.SEQ ID NO: 903. SEQ ID NO: 261, SEQ ID NO: 71, SEQ ID NO: 955, SEQ ID NO: 361, SEQ ID NO: 58. SEQ ID NO: 114, SEQ ID NO: 940, SEQ ID NO: 960, SEQ ID NO: 144, SEQ ID NO: 362. SEQ ID NO: 40. SEQ ID NO: 285, SEQ ID NO: 11, SEQ -13- ID NO: 161. SEQ ID NO: 974, SEQ ID NO: 111, SEQ ID NO: 316. SEQ ID NO: 257, SEQ ID NO: 78, and SEQ ID NO: 966.
In yet a further embodiment, the H pylori cell envelope polypeptide or a fragment thereof is an H. pylori outer membrane polypeptide or a fragment thereof encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 1173, SEQ ID NO: 1405, SEQ ID NO: 1406, SEQ ID NO: 1410, SEQ ID NO: 1086, SEQ ID NO: 1322. SEQ ID NO: 1266, SEQ ID NO: 1282. SEQ ID NO: 1271, SEQ ID NO: 1208, SEQ ID NO: 1126, SEQ ID NO: 1270, SEQ ID NO: 1278, SEQ ID NO: 1419, SEQ ID NO: 1125, SEQ ID NO: 1181, SEQ ID NO: 1416, SEQ ID NO: 1096, SEQ ID NO: 1082, SEQ ID NO: 1146, SEQ ID NO: 1145, SEQ ID NO: 1108, SEQ ID NO: 1148, SEQ ID NO: 1337, SEQ ID NO: 1338, SEQ ID NO: 1424, SEQ ID NO: 1000, SEQ ID NO: 1027. SEQ ID NO: 1175, SEQ ID NO: 1330. SEQ ID NO: 352, SEQ ID NO: 981, SEQ ID NO: 158. SEQ ID NO: 989, SEQ ID NO: 963, SEQ ID NO: 48, SEQ ID NO: 68, SEQ ID NO: 135, SEQ ID NO: 910, SEQ ID NO: 236, SEQ ID NO: 241, SEQ ID NO: 949, SEQ ID NO: 945. SEQ ID 15 NO: 207, and SEQ ID NO: 977.
Particularly preferred is an isolated nucleic acid comprising a nucleotide sequence encoding an H pylori cytoplasmic polypeptide or a fragment thereof. Such nucleic acid is selected from the group consisting of SEQ ID NO: 1147, SEQ ID NO: 1288, SEQ ID NO: 1324, SEQ ID NO: 1363, SEQ ID NO: 997, SEQ ID NO: 1015, SEQ ID NO: 1084. SEQ 20 ID NO: 1094, SEQ ID NO: 1099, SEQ ID NO: 1229, SEQ ID NO: 1250, SEQ ID NO: 1268, SEQ ID NO: 1293, SEQ ID NO: 1339, SEQ ID NO: 1408, SEQ ID NO: 1429, SEQ ID NO: 1434, SEQ ID NO: 1228, SEQ ID NO: 1031, SEQ ID NO: 1034, SEQ ID NO: 1008, SEQ ID NO: 1061, SEQ ID NO: 1064, SEQ ID NO: 1191, SEQ ID NO: 1217, SEQ ID NO: 1365. SEQ ID NO: 1394, SEQ ID NO: 1414, SEQ ID NO: 1415, SEQ ID NO: 25 1435. SEQ ID NO: 1058, SEQ ID NO: 1059, SEQ ID NO: 1080, SEQ ID NO: 1128, SEQ ID NO: 1133, SEQ ID NO: 1211, SEQ ID NO: 1252, SEQ ID NO: 1253, SEQ ID NO: 1286, SEQ ID NO: 1289. SEQ ID NO: 1291, SEQ ID NO: 1303, SEQ ID NO: 1396, SEQ ID NO: 996, SEQ ID NO: 1095. SEQ ID NO: 1156, SEQ ID NO: 1158, SEQ ID NO: 1159, SEQ ID NO: 1277, SEQ ID NO: 1038, SEQ ID NO: 1257, SEQ ID NO: 1357, SEQ ID NO: 1436, SEQ ID NO: 1047. SEQ ID NO: 1055, SEQ ID NO: SEQ ID NO: 1141, SEQ ID NO: 1227, SEQ ID NO: 1327. SEQ ID NO: 1412, SEQ ID NO: 1003, SEQ ID NO: 1087, SEQ ID NO: 1116, SEQ ID NO: 1130, SEQ ID NO: 1132, SEQ ID NO: 1185, SEQ ID NO: 1188. SEQ ID NO: 1198. SEQ ID NO: 1218, SEQ ID NO: 1244, SEQ ID NO: 1306. SEQ ID NO: 1325. SEQ ID NO: 1397, SEQ ID NO: 1398, SEQ ID NO: 1407, SEQ ID NO: 1433, SEQ ID NO: 1216. SEQ ID NO: 1239, SEQ ID NO: 1362, SEQ ID NO: 1017, SEQ ID NO: 1019. SEQ ID NO: 1360, SEQ ID NO: 1423, SEQ ID NO: 1425, SEQ ID NO: 1374, SEQ ID NO: 1028. SEQ ID NO: 1037, SEQ ID NO: 1077, SEQ ID NO: 1115, SEQ ID NO: 1232, SEQ ID NO: 1241, SEQ ID NO: 1267, SEQ ID NO: 1163, SEQ ID NO: 1068. SEQ ID NO: 1025. SEQ ID NO: 1042, SEQ ID NO: 1046, SEQ ID NO: -14- 1056, SEQ ID NO: 1039, SEQ ID NO: 1072, SEQ ID NO: 1073, SEQ ID NO: 1092, SEQ ID NO: 1100, SEQ ID NO: 1102. SEQ ID NO: 1103, SEQ ID NO: 1104. SEQ ID NO: 1111, SEQ ID NO: 1119, SEQ ID NO: 1136, SEQ ID NO: 1137, SEQ ID NO: 1140, SEQ ID NO: 1142. SEQ ID NO: 1233, SEQ ID NO: 1238, SEQ ID NO: 1243, SEQ ID NO: 1245, SEQ ID NO: 1247, SEQ ID NO: 1249, SEQ ID NO: 1261, SEQ ID NO: 1269, SEQ ID NO: 1279, SEQ ID NO: 1284, SEQ ID NO: 1290, SEQ ID NO: 1297, SEQ ID NO: 1328, SEQ ID NO: 1370, SEQ ID NO: 1372, SEQ ID NO: 1377, SEQ ID NO: 1383, SEQ ID NO: 1384, SEQ ID NO: 1385, SEQ ID NO: 1388, SEQ ID NO: 1401, SEQ ID NO: 1402, SEQ ID NO: 1418, SEQ ID NO: 1420, SEQ ID NO: 1427, SEQ ID NO: 1070, SEQ ID NO: 1151, SEQ ID NO: 1176, SEQ ID NO: 999, SEQ ID NO: 1006, SEQ ID NO: 1012, SEQ ID NO: 1018, SEQ ID NO: 1030, SEQ ID NO: 1033, SEQ ID NO: 1041, SEQ ID NO: 1049, SEQ ID NO: 1054, SEQ ID NO: 1057, SEQ ID NO: 1090, SEQ ID NO: 1097, SEQ ID NO: 1129, SEQ ID NO: 1139, SEQ ID NO: 1143, SEQ ID NO: 1152. SEQ ID NO: 1153. SEQ ID NO: 1155, SEQ ID NO: 1161, SEQ ID NO: 1162, SEQ ID NO: 1169, 15 SEQ ID NO: 1170. SEQ ID NO: 1171. SEQ ID NO: 1180, SEQ ID NO: 1194. SEQ ID NO: 1195, SEQ ID NO: 1199, SEQ ID NO: 1200, SEQ ID NO: 1201, SEQ ID NO: 1202, SSEQ ID NO: 1205, SEQ ID NO: 1312, SEQ ID NO: 1336, SEQ ID NO: 1349, SEQ ID NO: 1355, SEQ ID NO: 1359, SEQ ID NO: 1413, SEQ ID NO: 1426. SEQ ID NO: 1430, SEQ ID NO: 882, SEQ ID NO: 382, SEQ ID NO: 130, SEQ ID NO: 230, SEQ ID NO: 20 269, SEQ ID NO: 312, SEQ ID NO: 211, SEQ ID NO: 959, SEQ ID NO: 938, SEQ ID *NO: 110, SEQ ID NO: 244, SEQ ID NO: 328, SEQ ID NO: 235, SEQ ID NO: 315, SEQ ID NO: 296, SEQ ID NO: 976, SEQ ID NO: 321, SEQ ID NO: 43, SEQ ID NO: 281, SEQ ID NO: 326, SEQ ID NO: 272, SEQ ID NO: 344, SEQ ID NO: 139, SEQ ID NO: 30, SEQ ID NO: 220, SEQ ID NO: 364, SEQ ID NO: 369, SEQ ID NO: 372, SEQ ID NO: 991, 25 SEQ ID NO: 128, SEQ ID NO: 347, SEQ ID NO: 52, SEQ ID NO: 12, SEQ ID NO: 247.
SEQ ID NO: 64, SEQ ID NO: 101, SEQ ID NO: 338, SEQ ID NO: 83, SEQ ID NO: 46, SEQ ID NO: 348, SEQ ID NO: 223, SEQ ID NO: 39, SEQ ID NO: 232, SEQ ID NO: 168, SEQ ID NO: 65, SEQ ID NO: 952, SEQ ID NO: 341, SEQ ID NO: 69, SEQ ID NO: 924, SEQ ID NO: 4, SEQ ID NO: 197, SEQ ID NO: 313, SEQ ID NO: 119, SEQ ID NO: 188, SEQ ID NO: 956, SEQ ID NO: 935, SEQ ID NO: 246, SEQ ID NO: 196, SEQ ID NO: 376, SEQ ID NO: 172, SEQ ID NO: 25, SEQ ID NO: 126, SEQ ID NO: 951, SEQ ID NO: 147, SEQ ID NO: 895, SEQ ID NO: 14, SEQ ID NO: 154, SEQ ID NO: 277, SEQ ID NO: 363, SEQ ID NO: 342, SEQ ID NO: 378, SEQ ID NO: 130, SEQ ID NO: 198, SEQ ID NO: 243, SEQ ID NO: 19, SEQ ID NO: 9, SEQ ID NO: 149, SEQ ID NO: 167, SEQ ID NO: 349, SEQ ID NO: 209, SEQ ID NO: 990, SEQ ID NO: 185, SEQ ID NO: 883, SEQ ID NO: 8, SEQ ID NO: 887, SEQ ID NO: 350, SEQ ID NO: 987, SEQ ID NO: 63, SEQ ID NO: 249, SEQ ID NO: 118, SEQ ID NO: 132, SEQ ID NO: 47, SEQ ID NO: 106, SEQ ID NO: 324, SEQ ID NO: 155, SEQ ID NO: 121, SEQ ID NO: 153, SEQ ID NO: 87, SEQ ID NO: 986. SEQ ID NO: 262, SEQ ID NO: 333, SEQ ID NO: 36. SEQ ID NO: 982, SEQ ID NO: 986. SEQ ID NO: 262. SEQ ID NO: 333. SEQ ID NO: 36. SEQ ID NO: 982, SEQ ID NO: 180, SEQ ID NO: 84, SEQ ID NO: 900. SEQ ID NO: 20. SEQ ID NO: 7, SEQ ID NO: 61, SEQ ID NO: 253, SEQ ID NO: 120, SEQ ID NO: 268, SEQ ID NO: 299, SEQ ID NO: 942, SEQ ID NO: 173, SEQ ID NO: 187, SEQ ID NO: 187, SEQ ID NO: 234, SEQ ID NO: 112, SEQ ID NO: 324. SEQ ID NO: 971, SEQ ID NO: 62, SEQ ID NO: 308, SEQ ID NO: 74, SEQ ID NO: 1, SEQ ID NO: 266. SEQ ID NO: 337, SEQ ID NO: 93, SEQ ID NO: 44, SEQ ID NO: 335, SEQ ID NO: 368, SEQ ID NO: 208, SEQ ID NO: 358, SEQ ID NO: 923, SEQ ID NO: 310, SEQ ID NO: 26, SEQ ID NO: 279, SEQ ID NO: 890, SEQ ID NO: 325, SEQ ID NO: 109, SEQ ID NO: 143, SEQ ID NO: 918, SEQ ID NO: 252, SEQ ID NO: 953, SEQ ID NO: 902, SEQ ID NO: 174, SEQ ID NO: 73, SEQ ID NO: 898, SEQ ID NO: 300, SEQ ID NO: 356, SEQ ID NO: 298, SEQ ID NO: 354, SEQ ID NO: 138, SEQ ID NO: 319, SEQ ID NO: 80, SEQ ID NO: 933, SEQ ID NO: 891, SEQ ID NO: 366, SEQ ID NO: 113, SEQ ID NO: 320, SEQ ID NO: 915, SEQ ID NO: 351, SEQ ID NO: 162, SEQ ID NO: 965, SEQ ID NO: 67, SEQ ID NO: 314, SEQ ID NO: 904, SEQ ID NO: 345, SEQ ID NO: 374, SEQ ID NO: 962. SEQ ID NO: 270, SEQ ID NO: 186, SEQ ID NO: 15 SEQ ID NO: 379. SEQ ID NO: 889, SEQ ID NO: 967, SEQ ID NO: 973, SEQ ID NO: 280, SEQ ID NO: 170, SEQ ID NO: 985, and SEQ ID NO: 932.
In one embodiment, the H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof involved in energy conversion encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 1147, SEQ ID NO: 20 1288, SEQ ID NO: 1324, SEQ ID NO: 1363, SEQ ID NO: 882, SEQ ID NO: 382, SEQ ID NO: 130, and SEQ ID NO: 230.
In another embodiment, the H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof involved in amino acid metabolism encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 997, SEQ 25 ID NO: 1015. SEQ ID NO: 1084, SEQ IDNO: 1094, SEQ ID NO: 1099, SEQ ID NO: 1229. SEQ ID NO: 1250, SEQ ID NO: 1268, SEQ ID NO: 1293, SEQ ID NO: 1339, SEQ ID NO: 1408, SEQ ID NO: 1429, SEQ ID NO: 1434, SEQ ID NO: 1228, SEQ ID NO: 1031, SEQ ID NO: 1034, SEQ ID NO: 1008, SEQ ID NO: 269, SEQ ID NO: 312, SEQ ID NO: 211, SEQ ID NO: 959, SEQ ID NO: 938, SEQ ID NO: 110, SEQ ID NO: 244, SEQ ID NO: 328, SEQ ID NO: 235. SEQ ID NO: 315, SEQ ID NO: 296. SEQ ID NO: 976, SEQ ID NO: 321, SEQ ID NO: 43, SEQ ID NO: 281, SEQ ID NO: 326, and SEQ ID NO: 272.
In yet another embodiment, the H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof involved in nucleotide metabolism encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 1061, SEQ ID NO: 1064, SEQ ID NO: 1191, SEQ ID NO: 1217, SEQ ID NO: 1365, SEQ ID NO: 1394, SEQ ID NO: 1414. SEQ ID NO: 1415, SEQ ID NO: 1435, SEQ ID NO: 1058, SEQ ID NO: 1059, SEQ ID NO: 344, SEQ ID NO: 139, SEQ ID NO: 30, SEQ ID NO: 220, SEQ ID NO: 364. SEQ ID NO: 369. SEQ ID NO: 372. SEQ ID NO: 991, SEQ ID NO: 128, SEQ ID NO: 347, and SEQ ID NO: 52.
In yet a further embodiment, the H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof involved in carbohydrate metabolism encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 1080. SEQ ID NO: 1128, SEQ ID NO: 1133, SEQ ID NO: 1211, SEQ ID NO: 1252, SEQ ID NO: 1253, SEQ ID NO: 1286, SEQ ID NO: 1289, SEQ ID NO: 1291, SEQ ID NO: 1303, SEQ ID NO: 1396, SEQ ID NO: 996, SEQ ID NO: 12, SEQ ID NO: 247, SEQ ID NO: 64, SEQ ID NO: 101, SEQ ID NO: 338, SEQ ID NO: 83, SEQ ID NO: 46, SEQ ID NO: 348, SEQ ID NO: 223, SEQ ID NO: 39, SEQ ID NO: 232. and SEQ ID NO: 168.
In another embodiment, the H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof involved in cofactor metabolism encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 1095, SEQ ID NO: 1156. SEQ ID NO: 1158, SEQ ID NO: 1159, SEQ ID NO: 1277, SEQ ID NO: 1038, SEQ 15 ID NO: 65. SEQ ID NO: 952. SEQ ID NO: 341, SEQ ID NO: 69, SEQ ID NO: 924, and SEQ ID NO: 4.
In another embodiment, the H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof involved in lipid metabolism encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 1257, SEQ ID NO: S 20 1357, SEQ ID NO: 1436, SEQ ID NO: 197, SEQ ID NO: 313, and SEQ ID NO: 119.
In another embodiment, the H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof involved in mRNA translation and ribosome biogenesis encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 1047, SEQ ID NO: 1055, SEQ ID NO:. SEQ ID NO: 1141, SEQ ID NO: 1227, SEQ ID NO: 1327, SEQ ID NO: 1412. SEQ ID NO: 188, SEQ ID NO: 956. SEQ ID NO: 935. SEQ ID NO: 246. SEQ ID NO: 196, and SEQ ID NO: 376.
In another embodiment, the H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof involved in genome replication, transcription, recombination and repair encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 1003, SEQ ID NO: 1087, SEQ ID NO: 1116, SEQ ID NO: 1130, SEQ ID NO: 1132, SEQ ID NO: 1185, SEQ ID NO: 1188, SEQ ID NO: 1198. SEQ ID NO: 1218, SEQ ID NO:-1244, SEQ ID NO: 1306, SEQ ID NO: 1325, SEQ ID NO: 1397, SEQ ID NO: 1398, SEQ ID NO: 1407, SEQ ID NO: 1433, SEQ ID NO: 172, SEQ ID NO: SEQ ID NO: 126, SEQ ID NO: 951, SEQ ID NO: 147, SEQ ID NO: 895, SEQ ID NO: 14, SEQ ID NO: 154, SEQ ID NO: 277. SEQ ID NO: 363, SEQ ID NO: 342, SEQ ID NO: 378, SEQ ID NO: 130, SEQ ID NO: 198, SEQ ID NO: 243, SEQ ID NO: 19, and SEQ ID NO: 9.
In another embodiment, the H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof involved in outer membrane or cell wall biosynthesis encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 1216, SEQ ID NO: 1239, SEQ ID NO: 1362, SEQ ID NO: 1017, SEQ ID NO: 1019, SEQ ID NO: 1360, SEQ ID NO: 149, SEQ ID NO: 167, SEQ ID NO: 349, SEQ ID NO: 209, SEQ ID NO: 990, SEQ ID NO: 185, SEQ ID NO: 883, and SEQ ID NO: 8.
In yet another embodiment, the H. pylori cytoplasmic polypeptide is an H. pylori chaperone polypeptide or a fragment thereof encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 1423, SEQ ID NO: 1425, SEQ ID NO: 1374, SEQ ID NO: 887, SEQ ID NO: 350, and SEQ ID NO: 987.
Particularly preferred is an isolated nucleic acid comprising a nucleotide sequence encoding an H. pylori secreted or periplasmic polypeptide or a fragment thereof. Such nucleic acid is selected from the group consisting of SEQ ID NO: 1004, SEQ ID NO: 1138, SEQ ID NO: 1067, SEQ ID NO: 1078, SEQ ID NO: 1314, SEQ ID NO: 1319, SEQ ID NO: 1378, SEQ ID NO: 1105, SEQ ID NO: 1114, SEQ ID NO: 1118. SEQ ID NO: 1120, SEQ ID NO: 1123, SEQ ID NO: 1127, SEQ ID NO: 1212, SEQ ID NO: 1223, SEQ ID 15 NO: 1225, SEQ ID NO: 1246, SEQ ID NO: 1248, SEQ ID NO: 1259. SEQ ID NO: 1264, SEQ ID NO: 1265, SEQ ID NO: 1281, SEQ ID NO: 1285, SEQ ID NO: 1294, SEQ ID NO: 1298, SEQ ID NO: 1299, SEQ ID NO: 1315, SEQ ID NO: 1316, SEQ ID NO: 1317, SEQ ID NO: 1318, SEQ ID NO: 1344, SEQ ID NO: 1351, SEQ ID NO: 1353, SEQ ID NO: 1373, SEQ ID NO: 1380, SEQ ID NO: 1387, SEQ ID NO: 1389, SEQ ID NO: 1393, 20 SEQ ID NO: 1411, SEQ ID NO: 1428, SEQ ID NO: 1431, SEQ ID NO: 1439, SEQ ID S° NO: 1043, SEQ ID NO: 1183, SEQ ID NO: 1184, SEQ ID NO: 1196, SEQ ID NO: 1197, SEQ ID NO: 1203, SEQ ID NO: 995, SEQ ID NO: 998, SEQ ID NO: 1001, SEQ ID NO: S1022. SEQ ID NO: 1023, SEQ ID NO: 1029, SEQ ID NO: 1040, SEQ ID NO: 1051, SEQ ID NO: 1062, SEQ ID NO: 1154, SEQ ID NO.: 1320, SEQ ID NO: 1075, SEQ ID NO: 1106, SEQ ID NO: 1109, SEQ ID NO: 1134, SEQ ID NO: 1221. SEQ ID NO: 1226, SEQ ID NO: 1235, SEQ ID NO: 1301, SEQ ID NO: 1311, SEQ ID NO: 1326, SEQ ID NO: 1341, SEQ ID NO: 1354, SEQ ID NO: 1364, SEQ ID NO: 1366, SEQ ID NO: 1376, SEQ ID NO: 1391, SEQ ID NO: 1395, SEQ ID NO: 1445, SEQ ID NO: 1079, SEQ ID NO: 1186, SEQ ID NO: 1010, SEQ ID NO: 1016, SEQ ID NO: 1172, SEQ ID NO: 1174, SEQ ID NO: 117, SEQ ID NO: 254, SEQ ID NO: 24, SEQ ID NO: 242, SEQ ID NO: 950, SEQ ID NO: 263, SEQ ID NO: 286, SEQ ID NO: 947, SEQ ID NO: 51, SEQ ID NO: 177, SEQ ID NO: 156, SEQ ID NO: 190, SEQ ID NO: 375, SEQ ID NO: 222, SEQ ID NO: 21, SEQ ID NO: 912, SEQ ID NO: 148, SEQ ID NO: 202, SEQ ID NO: 224, SEQ ID NO: 112, SEQ ID NO: 32, SEQ ID NO: 339, SEQ ID NO: 182, SEQ ID NO: 228, SEQ ID NO: 152, SEQ ID NO: 219, SEQ ID NO: 137, SEQ ID NO: 318, SEQ ID NO: 141, SEQ ID NO: 165, SEQ ID NO: 334, SEQ ID NO: 13, SEQ ID NO: 297, SEQ ID NO: 35, SEQ ID NO: 216, SEQ ID NO: 908, SEQ ID NO: 124, SEQ ID NO: 75, SEQ ID NO: 927, SEQ ID NO: 221. SEQ ID NO: 178, SEQ ID NO: 169, SEQ ID NO: 293, SEQ ID NO: 289, SEQ ID NO: 926, SEQ ID NO: 948, SEQ ID NO: 115, SEQ ID NO: 251, SEQ ID NO: 345, SEQ -18- ID NO: 17. SEQ ID NO: 920. SEQ ID NO: 95, SEQ ID NO: 86, SEQ ID NO: 360, SEQ ID NO: 271, SEQ ID NO: 970, SEQ ID NO: 288, SEQ ID NO: 282. SEQ ID NO: 98, SEQ ID NO: 29, SEQ ID NO: 317, SEQ ID NO: 343, SEQ ID NO: 291. SEQ ID NO: 108, SEQ ID NO: 377, SEQ ID NO: 305, SEQ ID NO: 305, SEQ ID NO: 100. SEQ ID NO: 988. SEQ ID NO: 212, SEQ ID NO: 884, SEQ ID NO: 37, SEQ ID NO: 968, SEQ ID NO: 975, SEQ ID NO: 237, SEQ ID NO: 335, SEQ ID NO: 260, SEQ ID NO: 370, SEQ ID NO: 91. SEQ ID NO: 276, SEQ ID NO: 311. SEQ ID NO: 173, SEQ ID NO: 102, SEQ ID NO: 304, SEQ ID NO: 380, SEQ ID NO: 127, SEQ ID NO: 993, SEQ ID NO: 925. SEQ ID NO: 181, and SEQ ID NO: 171.
Particularly preferred is an isolated nucleic acid comprising a nucleotide sequence encoding an H. pylori surface or membrane polypeptide or a fragment thereof. Such nucleic acid is selected from the group consisting of SEQ ID NO: 1060, SEQ ID NO: 1110, SEQ ID NO: 1112, SEQ ID NO: 1230. SEQ ID NO: 1260, SEQ ID NO: 1280. SEQ ID NO: 1292, SEQ ID NO: 1296. SEQ ID NO: 1307. SEQ ID NO: 1442, SEQ ID NO: 1444.
SEQ ID NO: 1122. SEQ ID NO: 1254, SEQ ID NO: 1256, SEQ ID NO: 1272. SEQ ID NO: 1275, SEQ ID NO: 1309, SEQ ID NO: 1313, SEQ ID NO: 1347, SEQ ID NO: 1352, SEQ ID NO: 1356, SEQ ID NO: 1438, SEQ ID NO: 1441, SEQ ID NO: 1009, SEQ ID NO: 1026, SEQ ID NO: 1048, SEQ ID NO: 1063, SEQ ID NO: 1190, SEQ ID NO: 1083, SEQ ID NO: 1113. SEQ ID NO: 1222, SEQ ID NO: 1295, SEQ ID NO: 1343. SEQ ID NO: 1392, SEQ ID NO: 1443, SEQ ID NO: 1085, SEQ ID NO: 1093, SEQ ID NO: 1117.
SEQ ID NO: 1121, SEQ ID NO: 1131, SEQ ID NO: 1287, SEQ ID NO: 1440, SEQ ID NO: 1209, SEQ ID NO: 1342, SEQ ID NO: 1381, SEQ ID NO: 1390, SEQ ID NO: 1409, SEQ ID NO: 1035, SEQ ID NO: 1014, SEQ ID NO: 1088, SEQ ID NO: 1242, SEQ ID NO: 1178, SEQ ID NO: 1089. SEQ ID NO: 1340, SEQ ID NO: 1074. SEQ ID NO: 1107, SEQ ID NO: 1204, SEQ ID NO: 1066. SEQ ID NO: 381, SEQ ID NO: 229, SEQ ID NO: S323, SEQ ID NO: 371, SEQ ID NO: 284, SEQ ID NO: 116, SEQ ID NO: 3. SEQ ID NO: 6, SEQ ID NO: 907, SEQ ID NO: 193, SEQ ID NO: 145. SEQ ID NO: 59. SEQ ID NO: 322, SEQ ID NO: 94, SEQ ID NO: 306, SEQ ID NO: 939. SEQ ID NO: 205, SEQ ID NO: 123, SEQ ID NO: 906, SEQ ID NO: 928, SEQ ID NO: 346, SEQ ID NO: 129. SEQ ID 30 NO: 307, SEQ ID NO: 133, SEQ ID NO: 131, SEQ ID NO: 886, SEQ ID NO: 179, SEQ ID NO: 104, SEQ ID NO: 213, SEQ ID NO: 359, SEQ ID NO: 140, SEQ ID NO: 146.
SEQ ID NO: 327, SEQ-ID NO: 365, SEQ ID NO: 33, SEQ ID NO: 331, SEQ ID NO: 175, SEQ ID NO: 200, SEQ ID NO: 292, SEQ ID NO: 23, SEQ ID NO: 336, SEQ ID NO: 301, SEQ ID NO: 28, SEQ ID NO: 941, SEQ ID NO: 103, SEQ ID NO: 231, SEQ ID NO: 176, SEQ ID NO: 31, SEQ ID NO: 917. SEQ ID NO: 151, SEQ ID NO: 922, SEQ ID NO: 265, SEQ ID NO: 142, SEQ ID NO: 259, SEQ ID NO: 122, SEQ ID NO: 206, SEQ ID NO: 96, SEQ ID NO: 353, SEQ ID NO: 38, SEQ ID NO: 89, SEQ ID NO: 77, SEQ ID NO: 954.
SEQ ID NO: 264, SEQ ID NO: 937, SEQ ID NO: 226, SEQ ID NO: 283, SEQ ID NO: 88.
I
-19- SEQ ID NO: 125, SEQ ID NO: 183, SEQ ID NO: 195. SEQ ID NO: 81, SEQ ID NO: 901, SEQ ID NO: 82, SEQ ID NO: 42, SEQ ID NO: 881. and SEQ ID NO: 885.
In one embodiment, the H pylori surface or membrane polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof having at least one membrane spanning region encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 1060, SEQ ID NO: 1110, SEQ ID NO: 1112, SEQ ID NO: 1230, SEQ ID NO: 1260, SEQ ID NO: 1280, SEQ ID NO: 1292, SEQ ID NO: 1296, SEQ ID NO: 1307, SEQ ID NO: 1442, SEQ ID NO: 1444, SEQ ID NO: 381. SEQ ID NO: 229, SEQ ID NO: 323, SEQ ID NO: 371, SEQ ID NO: 284, SEQ ID NO: 116, SEQ ID NO: 3, SEQ ID NO: 6, SEQ ID NO: 907, SEQ ID NO: 193, SEQ ID NO: 145, SEQ ID NO: 59, SEQ ID NO: 322, SEQ ID NO: 94, SEQ ID NO: 306. and SEQ ID NO: 881.
In another embodiment, the H. pylori surface or membrane polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof having at least two membrane spanning regions encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 1122. SEQ ID NO: 1254, SEQ ID NO: 1256, SEQ ID NO: 1272, SEQ ID NO: 1275, SEQ ID NO: 1309, SEQ ID NO: 1313, SEQ ID NO: 1347, SEQ ID NO: 1352, SEQ ID NO: 1356, SEQ ID NO: 1438, SEQ ID NO: 1441, SEQ ID NO: 1009, SEQ ID NO: 1026, SEQ ID NO: 1048, SEQ ID NO: 1063, SEQ ID NO: 1190, SEQ ID NO: 939, SEQ ID NO: 205, SEQ ID NO: 123, SEQ ID NO: 906, SEQ ID NO: 928, SEQ ID NO: 20 346, SEQ ID NO: 129, SEQ ID NO: 307, SEQ ID NO: 133, SEQ ID NO: 131, SEQ ID NO: 886, SEQ ID NO: 179, SEQ ID NO: 104, SEQ ID NO: 213, SEQ ID NO: 359, SEQ ID NO: 140. SEQ ID NO: 146, SEQ ID NO: 327, and SEQ ID NO: 365.
In yet another embodiment, the H. pylori surface or membrane polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof having at least three 25 membrane spanning regions encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 1083. SEQ ID NO: 1113, SEQ ID NO: 1222, SEQ ID NO: 1295, SEQ ID NO: 1343, SEQ ID NO: 1392, SEQ ID NO: 1443, SEQ ID NO: 33, SEQ ID NO: 331, SEQ ID NO: 175, SEQ ID NO: 200, SEQ ID NO: 292, SEQ ID NO: 23, and SEQ ID NO: 336.
In yet a further embodiment, the H. pylori surface or membrane polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof having at least four membrane spanning regions encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 1085. SEQ ID NO: 1093, SEQ ID NO: 1117, SEQ ID NO: 1121, SEQ ID NO: 1131, SEQ ID NO: 1287, SEQ ID NO: 1440, SEQ ID NO: 1209, SEQ ID NO: 301, SEQ ID NO: 28, SEQ ID NO: 941, SEQ ID NO: 103, SEQ ID NO: 231, SEQ ID NO: 176, SEQ ID NO: 31, SEQ ID NO: 917, SEQ ID NO: 151. and SEQ ID NO: .922.
In another embodiment, the H. pylori surface or membrane polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof having at least five membrane spanning regions encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 1342, SEQ ID NO: 1381, SEQ ID NO: 1390, SEQ ID NO: 1409, SEQ ID NO: 1035, SEQ ID NO: 265, SEQ ID NO: 142. SEQ ID NO: 259, SEQ ID NO: 122, SEQ ID NO: 206, and SEQ ID NO: 885.
In another embodiment, the H. pylori surface or membrane polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof having at least six membrane spanning regions encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 1014, SEQ ID NO: 1088, SEQ ID NO: 1242, SEQ ID NO: 1178, SEQ ID NO: 96, SEQ ID NO: 353, SEQ ID NO: 38, SEQ ID NO: 89, SEQ ID NO: 77, SEQ ID NO: 954, SEQ ID NO: 264.
In another embodiment, the H. pylori surface or membrane polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof having at least seven membrane spanning regions encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 1089, SEQ ID NO: 1340, SEQ ID NO: 1074, SEQ ID NO: 1107, SEQ ID NO: 1204, SEQ ID NO: 1066, SEQ ID NO: 937, SEQ ID NO: 226, SEQ ID NO: 283, SEQ ID NO: 88, SEQ ID NO: 125, SEQ ID NO: 183. SEQ ID NO: 195, SEQ ID NO: 81. SEQ ID NO: 901, SEQ ID NO: 82, and SEQ ID NO: 42.
Particularly preferred is a purified or isolated H. pylori cell envelope polypeptide or a fragment thereof, wherein the polypeptide is selected from the group consisting of SEQ ID NO: 1471, SEQ ID NO: 1472, SEQ ID NO: 1487, SEQ ID NO: 1501, SEQ ID NO: 1522, SEQ ID NO: 1552, SEQ ID NO: 1586. SEQ ID NO: 1727, SEQ ID NO: 1601, SEQ 20 ID NO: 1638, SEQ ID NO: 1643, SEQ ID NO: 1812, SEQ ID NO: 1830, SEQ ID NO: 1850, SEQ ID NO: 1854, SEQ ID NO: 1851, SEQ ID NO: 1640, SEQ ID NO: 1453, SEQ ID NO: 1664, SEQ ID NO: 1665, SEQ ID NO: 1666, SEQ ID NO: 1685, SEQ ID NO: 1687, SEQ ID NO: 1688, SEQ ID NO: 1675, SEQ ID NO: 1702, SEQ ID NO: 1713, SEQ ID NO: 1600, SEQ ID NO: 1671, SEQ ID NO:.1691, SEQ ID NO: 1615. SEQ ID NO: 1616. SEQ ID NO: 1855, SEQ ID NO: 1595. SEQ ID NO: 1633, SEQ ID NO: 1608, SEQ •ID NO: 1611, SEQ ID NO: 1751, SEQ ID NO: 1772, SEQ ID NO: 1774, SEQ ID NO: 1780. SEQ ID NO: 1783, SEQ ID NO: 1796. SEQ ID NO: 1809, SEQ ID NO: 1826, SEQ ID NO: 1868, SEQ ID NO: 1734, SEQ ID NO: 1786, SEQ ID NO: 1819, SEQ ID NO: 1630, SEQ ID NO: 1706, SEQ ID NO: 1709, SEQ ID NO: 1495, SEQ ID NO: 1724, SEQ ID NO: 1670, SEQ ID NO: 1725, SEQ ID NO: 1661, SEQ ID NO: 1873, SEQ ID NO: 1753, SEQ ID NO: 1759, SEQ ID NO: 1761, SEQ ID NO: 1782, SEQ ID NO: 1883, SEQ ID NO: 1503, SEQ ID NO: 1542, SEQ ID NO: 1872, SEQ ID NO: 1520, SEQ ID NO: 1456. SEQ ID NO: 1458, SEQ ID NO: 1617. SEQ ID NO: 1628, SEQ ID NO: 1644, SEQ ID NO: 1657, SEQ ID NO: 1658, SEQ ID NO: 1755, SEQ ID NO: 1756, SEQ ID NO: 1797, SEQ ID NO: 1799, SEQ ID NO: 1801. SEQ ID NO: 1483, SEQ ID NO: 1504, SEQ ID NO: 1532, SEQ ID NO: 1575, SEQ ID NO: 1833, SEQ ID NO: 1888, SEQ ID NO: 1714, SEQ ID NO: 1624, SEQ ID NO: 1856. SEQ ID NO: 1857, SEQ ID NO: 1861, SEQ ID NO: 1537, SEQ ID NO: 1773, SEQ ID NO: 1717, SEQ ID NO: 1733, SEQ ID NO: 1722, SEQ ID NO: 1659, SEQ ID NO: 1577, SEQ ID NO: 1721, SEQ ID NO: 1729. SEQ ID NO: 1870, SEQ ID NO: 1576, SEQ ID NO: 1632. SEQ ID NO: 1867, SEQ ID NO: 1547, SEQ ID NO: 1533. SEQ ID NO: 1597, SEQ ID NO: 1596, SEQ ID NO: 1559. SEQ ID NO: 1599, SEQ ID NO: 1788, SEQ ID NO: 1789, SEQ ID NO: 1875, SEQ ID NO: 1451, SEQ ID NO: 1478, SEQ ID NO: 1626, SEQ ID NO: 1781, SEQ ID NO: 660. SEQ ID NO: 660, SEQ ID NO: 855, SEQ ID NO: 534, SEQ ID NO: 675, SEQ ID NO: 404, SEQ ID NO: 518, SEQ ID NO: 464, SEQ ID NO: 672, SEQ ID NO: 640, SEQ ID NO: 490. SEQ ID NO: 755, SEQ ID NO: 389, SEQ ID NO: 635, SEQ ID NO: 877, SEQ ID NO: 637, SEQ ID NO: 477, SEQ ID NO: 772, SEQ ID NO: 658, SEQ ID NO: 463, SEQ ID NO: 852, SEQ ID NO: 503, SEQ ID NO: 411, SEQ ID NO: 441, SEQ ID NO: 782, SEQ ID NO: 575, SEQ ID NO: 691, SEQ ID NO: 724, SEQ ID NO: 452, SEQ ID NO: 386. SEQ ID NO: 497, SEQ ID NO: 712, SEQ ID NO: 591, SEQ ID NO: 638, SEQ ID NO: 740, SEQ ID NO: 697, SEQ ID NO: 569, SEQ ID NO: 470, SEQ ID NO: 700. SEQ ID NO: 586, SEQ ID NO: 823, SEQ ID NO: 627, SEQ ID NO: 627, SEQ ID NO: 684, SEQ ID NO: 551, SEQ ID NO: 478, SEQ ID NO: 508, SEQ ID NO: 545, SEQ ID NO: 628. SEQ ID NO: 443. SEQ ID NO: 702. SEQ ID NO: 776, SEQ ID NO: 461, SEQ ID NO: 737, SEQ ID NO: 809, SEQ ID NO: 642. SEQ ID NO: 879, SEQ ID NO: 773. SEQ ID NO: 468, SEQ ID NO: 842, SEQ ID NO: 788, SEQ ID NO: 624, SEQ ID NO: 788, SEQ ID NO: 644, SEQ ID NO: 727, SEQ ID NO: 631, SEQ ID NO: 450, SEQ ID NO: 448, SEQ ID NO: 653, SEQ ID NO: 495, SEQ ID NO: 400, SEQ ID NO: 541, SEQ ID 20 NO: 673, SEQ ID NO: 482, SEQ ID NO: 622, SEQ ID NO: 689, SEQ ID NO: 736. SEQ ID NO: 417, SEQ ID NO: 716, SEQ ID NO: 762, SEQ ID NO: 395, SEQ ID NO: 587, SEQ ID NO: 669, SEQ ID NO: 758, SEQ ID NO: 593, SEQ ID NO: 451, SEQ ID NO: 827, SEQ ID NO: 502, SEQ ID NO: 719, SEQ ID NO: 469, SEQ ID NO: 715, SEQ ID NO: 847, SEQ ID NO: 453, SEQ ID NO: 527. SEQ ID NO: 652, SEQ ID NO: 745, SEQ ID NO: 567. SEQ ID NO: 848, SEQ ID NO: 430, SEQ ID NO: 748, SEQ ID NO: 396, SEQ ID NO: 588, SEQ ID NO: 795, SEQ ID NO: 523. SEQ ID NO: 791, SEQ ID NO: 714, SEQ ID NO: 481, SEQ ID NO: 765, SEQ ID NO: 837, SEQ ID NO: 833, SEQ ID NO: 585, SEQ ID NO: 865, SEQ ID NO: 764, SEQ ID NO: 440, SEQ ID NO: 465, SEQ ID NO: 555, SEQ ID NO: 526, SEQ ID NO: 687, SEQ ID NO: 692, SEQ ID NO: 693, 30 SEQ ID NO: 677, SEQ ID NO: 649, SEQ ID NO: 812, SEQ ID NO: 820, SEQ ID NO: 880, SEQ ID NO: 590, SEQ ID NO:713, SEQ ID NO:750, SEQ ID NO:613, SEQ ID NO: 437, SEQ ID NO: 556, SEQ ID NO: 657, SEQ ID NO: 402, SEQ ID NO: 623. SEQ ID NO: 862, SEQ ID NO: 449, SEQ ID NO: 690, SEQ ID NO: 424, SEQ ID NO: 821, SEQ ID NO: 432, SEQ ID NO: 811. SEQ ID NO: 554, and SEQ ID NO: 809.
In one embodiment, the H. pylori cell envelope polypeptide or a fragment thereof is an H. pylori flagella-associated polypeptide or a fragment thereof selected from the group consisting of SEQ ID NO: 1471, SEQ ID NO: 1472, SEQ ID NO: 1487, SEQ ID NO: 1501, SEQ ID NO: 1522, SEQ ID NO: 1552, SEQ ID NO: 1586, SEQ ID NO: 1727. SEQ ID NO: 1601, SEQ ID NO: 1638, SEQ ID NO: 1643, SEQ ID NO: 1812, SEQ ID NO: 1830, SEQ ID NO: 1850, SEQ ID NO: 1854, SEQ ID NO: 1851. SEQ ID NO: 1640. SEQ ID NO: 660, SEQ ID NO: 660, SEQ ID NO: 855. SEQ ID NO: 534, SEQ ID NO: 675. SEQ ID NO: 404, SEQ ID NO: 518. SEQ ID NO: 464, SEQ ID NO: 672, SEQ ID NO: 640, SEQ ID NO: 490, SEQ ID NO: 755, SEQ ID NO: 389, SEQ ID NO: 635, SEQ ID NO: 877, SEQ ID NO: 637, SEQ ID NO: 477, SEQ ID NO: 772, and SEQ ID NO: 658.
In another embodiment, the H. pylori cell envelope polypeptide or a fragment thereof is an H. pylori inner membrane polypeptide or a fragment thereof selected from the group consisting of SEQ ID NO: 1453, SEQ ID NO: 1664, SEQ ID NO: 1665. SEQ ID NO: 1666, SEQ ID NO: 1685, SEQ ID NO: 1687, SEQ ID NO: 1688. SEQ ID NO: 1675, SEQ ID NO: 1702, SEQ ID NO: 1713, SEQ ID NO: 1600, SEQ ID NO: 1671, SEQ ID NO: 1691, SEQ ID NO: 1615, SEQ ID NO: 1616. SEQ ID NO: 1855, SEQ ID NO: 1595, SEQ ID NO: 1633, SEQ ID NO: 1608. SEQ ID NO: 1611, SEQ ID NO: 1751, SEQ ID NO: 1772, SEQ ID NO: 1774, SEQ ID NO: 1780. SEQ ID NO: 1783, SEQ ID NO: 1796, SEQ ID NO: 1809, SEQ ID NO: 1826, SEQ ID NO: 1868. SEQ ID NO: 1734, SEQ ID NO: 1786, SEQ ID NO: 1819. SEQ ID NO: 1630. SEQ ID NO: 1706. SEQ ID NO: 1709, SEQ ID NO: 1495, SEQ ID NO: 1724, SEQ ID NO: 463, SEQ ID NO: 852. SEQ ID NO: 503, SEQ ID NO: 411, SEQ ID NO: 441, SEQ ID NO: 782, SEQ ID NO: 575, SEQ ID NO: 691, SEQ ID NO: 724, SEQ ID NO: 452, SEQ ID NO: 386, SEQ ID NO: 497, SEQ ID NO: 712, SEQ ID NO: 591, SEQ ID NO: 638, SEQ ID NO: 740, SEQ ID NO: 697, SEQ ID NO: 569, SEQ ID NO: 470, SEQ ID NO: 700, SEQ ID NO: 586, SEQ ID NO: 823, SEQ ID NO: 627, SEQ ID NO: 627, SEQ ID NO: 684, SEQ ID NO: 551, SEQ ID SNO: 478, SEQ ID NO: 508. SEQ ID NO: 545, SEQ ID NO: 628, SEQ ID NO: 443, SEQ ID NO: 702, SEQ ID NO: 776, SEQ ID NO: 461, SEQ ID NO: 737, SEQ ID NO: 809, SEQ ID NO: 642, SEQ ID NO: 879. SEQ ID NO: 773, SEQ ID NO: 468, SEQ ID NO: 842. SEQ ID NO: 788, SEQ ID NO: 624, SEQ ID NO: 788, SEQ ID NO: 644. SEQ ID NO: 727, SEQ ID NO: 631, SEQ ID NO: 450, SEQ ID NO: 448. and SEQ ID NO: 653.
In yet another embodiment, the H. pylori cell envelope polypeptide or a fragment thereof is an H. pylori transporter polypeptide or a fragment thereof selected from the group consisting of SEQ ID NO: 1670, SEQ ID NO: 1725, SEQ ID NO: 1661, SEQ ID NO: 1873, SEQ ID NO: 1753, SEQ ID NO: 1759, SEQ ID NO: 1761, SEQ ID NO: 1782, SEQ ID NO: 1883, SEQ ID NO: 1503, SEQ ID NO: 1542, SEQ ID NO: 1872, SEQ ID NO: 1520, SEQ ID NO: 1456, SEQ ID NO: 1458, SEQ ID NO: 1617, SEQ ID NO: 1628. SEQ ID NO: 1644, SEQ ID NO: 1657, SEQ ID NO: 1658, SEQ ID NO: 1755, SEQ ID NO: 1756, SEQ ID NO: 1797, SEQ ID NO: 1799, SEQ ID NO: 1801, SEQ ID NO: 1483, SEQ ID NO: 1504, SEQ ID NO: 1532, SEQ ID NO: 1575. SEQ ID NO: 1833, SEQ ID NO: 1888, SEQ ID NO: 1714, SEQ ID NO: 495, SEQ ID NO: 400, SEQ ID NO: 541. SEQ ID NO: 673, SEQ ID NO: 482, SEQ ID NO: 622, SEQ ID NO: 689, SEQ ID NO: 736, SEQ ID NO: 417, SEQ ID NO: 716, SEQ ID NO: 762, SEQ ID NO: 395. SEQ ID NO: 587, SEQ ID NO: 669, SEQ ID NO: 758, SEQ ID NO: 593, SEQ ID NO: 451, SEQ ID NO: 827, -23- SEQ ID NO: 502, SEQ ID NO: 719. SEQ ID NO: 469, SEQ ID NO: 715, SEQ ID NO: 847. SEQ ID NO: 453, SEQ ID NO: 527. SEQ ID NO: 652, SEQ ID NO: 745, SEQ ID NO: 567, SEQ ID NO: 848, SEQ ID NO: 430, SEQ ID NO: 748, SEQ ID NO: 396, SEQ ID NO: 588, SEQ ID NO: 795, SEQ ID NO: 523, SEQ ID NO: 791, SEQ ID NO: 714, SEQ ID NO: 481, and SEQ ID NO: 765.
In another embodiment, the H. pylori cell envelope polypeptide or a fragment thereof is an H. pylori outer membrane polypeptide or a fragment thereof selected from the group consisting of SEQ ID NO: 1624, SEQ ID NO: 1856, SEQ ID NO: 1857, SEQ ID NO: 1861, SEQ ID NO: 1537, SEQ ID NO: 1773, SEQ ID NO: 1717. SEQ ID NO: 1733, SEQ ID NO: 1722, SEQ ID NO: 1659, SEQ ID NO: 1577, SEQ ID NO: 1721. SEQ ID NO: 1729, SEQ ID NO: 1870, SEQ ID NO: 1576, SEQ ID NO: 1632. SEQ ID NO: 1867, SEQ ID NO: 1547, SEQ ID NO: 1533, SEQ ID NO: 1597, SEQ ID NO: 1596, SEQ ID NO: 1559. SEQ ID NO: 1599, SEQ ID NO: 1788, SEQ ID NO: 1789. SEQ ID NO: 1875, SEQ ID NO: 1451, SEQ ID NO: 1478. SEQ ID NO: 1626, SEQ ID NO: 1781, SEQ ID NO: 837, SEQ ID NO: 833, SEQ ID NO: 585. SEQ ID NO: 865, SEQ ID NO: 764, SEQ ID NO: 440, SEQ ID NO: 465, SEQ ID NO: 555, SEQ ID NO: 526, SEQ ID NO: 687, SEQ ID NO: 692, SEQ ID NO: 693, SEQ ID NO: 677, SEQ ID NO: 649, and SEQ ID NO: 812.
Particularly preferred is a purified or isolated H. pylori cytoplasmic polypeptide or a 20 fragment thereof, wherein the polypeptide is selected from the group consisting of SEQ ID NO: 1598, SEQ ID NO: 1739, SEQ ID NO: 1775, SEQ ID NO: 1814, SEQ ID NO: 1448, SEQ ID NO: 1466, SEQ ID NO: 1535, SEQ ID NO: 1545, SEQ ID NO: 1550, SEQ ID NO: 1680, SEQ ID NO: 1701, SEQ ID NO: 1719, SEQ ID NO: 1744, SEQ ID NO: 1790, o* SEQ ID NO: 1859, SEQ ID NO: 1880, SEQ ID NO: 1885, SEQ ID NO: 1679, SEQ ID NO: 1482, SEQ ID NO: 1485, SEQ ID NO: 1459, SEQ ID NO: 1512, SEQ ID NO: 1515, SEQ ID NO: 1642, SEQ ID NO: 1668, SEQ ID NO: 1816, SEQ ID NO: 1845. SEQ ID NO: 1865, SEQ ID NO: 1866, SEQ ID NO: 1886, SEQ ID NO: 1509, SEQ ID NO: 1510, SEQ ID NO: 1531, SEQ ID NO: 1579, SEQ ID NO: 1584, SEQ ID NO: 1662, SEQ ID NO: 1703, SEQ ID NO: 1704, SEQ ID NO: 1737, SEQ ID NO: 1740, SEQ ID NO: 1742, 30 SEQ ID NO: 1754, SEQ ID NO: 1847, SEQ ID NO: 1447, SEQ ID NO: 1546, SEQ ID NO: 1607, SEQ ID NO: 1609, SEQ ID NO: 1610, SEQ ID NO: 1728, SEQ ID NO: 1489, 99" SEQ ID NO: 1708, SEQ ID NO: 1808, SEQ ID NO: 1887, SEQ ID NO: 1498. SEQ ID NO: 1506, SEQ ID NO: 1592, SEQ ID NO: 1678, SEQ ID NO: 1778, SEQ ID NO: 1863, SEQ ID NO: 1454, SEQ ID NO: 1538, SEQ ID NO: 1567, SEQ ID NO: 1581, SEQ ID NO: 1583, SEQ ID NO: 1636. SEQ ID NO: 1639, SEQ ID NO: 1649. SEQ ID NO: 1669, SEQ ID NO: 1695, SEQ ID NO: 1757, SEQ ID NO: 1776, SEQ ID NO: 1848, SEQ ID NO: 1849, SEQ ID NO: 1858, SEQ ID NO: 1884, SEQ ID NO: 1667, SEQ ID NO: 1690, SEQ ID NO: 1813, SEQ ID NO: 1468, SEQ ID NO: 1470, SEQ ID NO: 1811. SEQ ID NO: 1874, SEQ ID NO: 1876. SEQ ID NO: 1825, SEQ ID NO: 1479, SEQ ID NO: 1488.
I
-24- SEQ ID NO: 1528, SEQ ID NO: 1566, SEQ ID NO: 1683. SEQ ID NO: 1692, SEQ ID NO: 1718, SEQ ID NO: 1614, SEQ ID NO: 1519, SEQ ID NO: 1476, SEQ ID NO: 1493, SEQ ID NO: 1497, SEQ ID NO: 1507, SEQ ID NO: 1490, SEQ ID NO: 1523. SEQ ID NO: 1524, SEQ ID NO: 1543, SEQ ID NO: 1551, SEQ ID NO: 1553, SEQ ID NO: 1554, SEQ ID NO: 1555, SEQ ID NO: 1562. SEQ ID NO: 1570, SEQ ID NO: 1587, SEQ ID NO: 1588, SEQ ID NO: 1591, SEQ ID NO: 1593, SEQ ID NO: 1684, SEQ ID NO: 1689, SEQ ID NO: 1694, SEQ ID NO: 1696, SEQ ID NO: 1698, SEQ ID NO: 1700, SEQ ID NO: 1712, SEQ ID NO: 1720, SEQ ID NO: 1730, SEQ ID NO: 1735, SEQ ID NO: 1741, SEQ ID NO: 1748, SEQ ID NO: 1779. SEQ ID NO: 1821, SEQ ID NO: 1823, SEQ ID NO: 1828, SEQ ID NO: 1834, SEQ ID NO: 1835, SEQ ID NO: 1836, SEQ ID NO: 1839, SEQ ID NO: 1852, SEQ ID NO: 1853, SEQ ID NO: 1869, SEQ ID NO: 1871, SEQ ID NO: 1878, SEQ ID NO: 1521, SEQ ID NO: 1602, SEQ ID NO: 1627, SEQ ID NO: 1450, SEQ ID NO: 1457. SEQ ID NO: 1463. SEQ ID NO: 1469, SEQ ID NO: 1481. SEQ ID NO: 1484, SEQ ID NO: 1492, SEQ ID NO: 1500, SEQ ID NO: 1505, SEQ ID NO: 1508.
SEQ ID NO: 1541, SEQ ID NO: 1548, SEQ ID NO: 1580. SEQ ID NO: 1590, SEQ ID NO: 1594, SEQ ID NO: 1603, SEQ ID NO: 1604, SEQ ID NO: 1606, SEQ ID NO: 1612, SEQ ID NO: 1613, SEQ ID NO: 1620, SEQ ID NO: 1621, SEQ ID NO: 1622. SEQ ID NO: 1631, SEQ ID NO: 1645. SEQ ID NO: 1646, SEQ ID NO: 1650, SEQ ID NO: 1651, SEQ ID NO: 1652, SEQ ID NO: 1653, SEQ ID NO: 1656, SEQ ID NO: 1763, SEQ ID 20 NO: 1787, SEQ ID NO: 1800, SEQ ID NO: 1806, SEQ ID NO: 1810, SEQ ID NO: 1864, SEQ ID NO: 1877, SEQ ID NO: 1881, SEQ ID NO: 390, SEQ ID NO: 876, SEQ ID NO: 547, SEQ ID NO: 678, SEQ ID NO: 729, SEQ ID NO: 786, SEQ ID NO: 654, SEQ ID NO: 734, SEQ ID NO: 646, SEQ ID NO: 522, SEQ ID NO: 696, SEQ ID NO: 807, SEQ ID NO: 683. SEQ ID NO: 790, SEQ ID NO: 763, SEQ ID NO: 806, SEQ ID NO: 799, SEQ ID NO: 434, SEQ ID NO: 743, SEQ ID NO: 804, SEQ ID NO: 733, SEQ ID NO: 826, SEQ ID NO: 562, SEQ ID NO: 420, SEQ ID NO: 664, SEQ ID NO: 850, SEQ ID NO: 857, SEQ ID NO: 861, SEQ ID NO: 872, SEQ ID NO: 544, SEQ ID NO: 830, SEQ ID NO: 446, SEQ ID NO: 397, SEQ ID NO: 699, SEQ ID NO: 459, SEQ ID NO: 509, SEQ ID NO: 818, SEQ ID NO: 488, SEQ ID NO: 438, SEQ ID NO: 831, SEQ ID NO: 30 667, SEQ ID NO: 429, SEQ ID NO: 680, SEQ ID NO: 597, SEQ ID NO: 460, SEQ ID NO: 709, SEQ ID NO: 822, SEQ ID NO: 466, SEQ ID NO: 584, SEQ ID NO: 388, SEQ ID NO: 631, SEQ ID NO: 787, SEQ ID NO: 532, SEQ ID NO: 619, SEQ ID NO: 723, SEQ ID NO: 641, SEQ ID NO: 698, SEQ ID NO: 630, SEQ ID NO: 869, SEQ ID NO: 601, SEQ ID NO: 415, SEQ ID NO: 542. SEQ ID NO: 704, SEQ ID NO: 572, SEQ ID NO: 467, SEQ ID NO: 399, SEQ ID NO: 579, SEQ ID NO: 739, SEQ ID NO: 849, SEQ ID NO: 824, SEQ ID NO: 871, SEQ ID NO: 547, SEQ ID NO: 633, SEQ ID NO: 695, SEQ ID NO: 405, SEQ ID NO: 394, SEQ ID NO: 761, SEQ ID NO: 574, SEQ ID NO: 596, SEQ ID NO: 832, SEQ ID NO: 651, SEQ ID NO: 867, SEQ ID NO: 614, SEQ ID NO: 401, SEQ ID NO: 393, SEQ ID NO: 413, SEQ ID NO: 835, SEQ ID NO: 863, SEQ ID NO: 458. SEQ ID NO: 701, SEQ ID NO: 531. SEQ ID NO: 550, SEQ ID NO: 439, SEQ ID NO: 516, SEQ ID NO: 802, SEQ ID NO: 581, SEQ ID NO: 535, SEQ ID NO: 578, SEQ ID NO: 492, SEQ ID NO: 858, SEQ ID NO: 720, SEQ ID NO: 813. SEQ ID NO: 426, SEQ ID NO: 834, SEQ ID NO: 609, SEQ ID NO: 489, SEQ ID NO: 480, SEQ ID NO: 406, SEQ ID NO: 392, SEQ ID NO: 456, SEQ ID NO: 707, SEQ ID NO: 533, SEQ ID NO: 728. SEQ ID NO: 769, SEQ ID NO: 671, SEQ ID NO: 602, SEQ ID NO: 618, SEQ ID NO: 618, SEQ ID NO: 682, SEQ ID NO: 524, SEQ ID NO: 802. SEQ ID NO: 785, SEQ ID NO: 457, SEQ ID NO: 781, SEQ ID NO: 473, SEQ ID NO: 384, SEQ ID NO: 726, SEQ ID NO: 817, SEQ ID NO: 498, SEQ ID NO: 436, SEQ ID NO: 815, SEQ ID NO: 856, SEQ ID NO: 650, SEQ ID NO: 844, SEQ ID NO: 580, SEQ ID NO: 783. SEQ ID NO: 416, SEQ ID NO: 741, SEQ ID NO: 442, SEQ ID NO: 803, SEQ ID NO: 520, SEQ ID NO: 566, SEQ ID NO: 557, SEQ ID NO: 706, SEQ ID NO: 710, SEQ ID NO: 487, SEQ ID NO: 603, SEQ ID NO: 472, SEQ ID NO: 476, SEQ ID NO: 770, SEQ ID NO: 841, SEQ ID NO: 768, SEQ ID NO: 839, SEQ ID NO: 560. SEQ ID NO: 796, SEQ ID NO: 483, SEQ ID NO: 634, SEQ ID NO: 445, SEQ ID NO: 853, SEQ ID NO: 525, SEQ ID NO: 798, SEQ ID NO: 549, SEQ ID NO: 836, SEQ ID NO: 589, SEQ ID NO: 760, SEQ ID NO: 462, SEQ ID NO: 789, SEQ ID NO: 507, SEQ ID NO: 828, SEQ ID NO: 866, SEQ ID NO: 754, SEQ ID NO: 730, SEQ ID NO: 617, SEQ ID NO: 455, SEQ ID NO: 873, SEQ ID NO: 435, SEQ ID NO: 766, SEQ ID NO: 793, SEQ ID 20 NO: 742, SEQ ID NO: 599, SEQ ID NO: 854, and SEQ ID NO: 632.
In one embodiment, the H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof involved in energy conversion selected from the group consisting of SEQ ID NO: 1598, SEQ ID NO: 1739, SEQ ID NO: 1775, SEQ ID NO: 1814, SEQ ID NO: 390, SEQ ID NO: 876, SEQ ID NO: 547, and SEQ ID NO: 678.
In another embodiment, the H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof involved in amino acid metabolism S selected from the group consisting of SEQ ID NO: 1448, SEQ ID NO: 1466, SEQ ID NO: 1535, SEQ ID NO: 1545, SEQ ID NO: 1550, SEQ ID NO: 1680, SEQ ID NO: 1701, SEQ ID NO: 1719, SEQ ID NO: 1744, SEQ ID NO: 1790, SEQ ID NO: 1859, SEQ ID NO: S 30 1880, SEQ ID NO: 1885, SEQ ID NO: 1679, SEQ ID NO: 1482, SEQ ID NO: 1485, SEQ ID NO: 1459, SEQ ID NO: 729, SEQ ID NO: 786, SEQ ID NO: 654, SEQ ID NO: 734, SEQ ID NO: 646, SEQ ID-NO: 522, SEQ ID NO: 696, SEQ ID NO: 807, SEQ ID NO: 683, SEQ ID NO: 790, SEQ ID NO: 763, SEQ ID NO: 806, SEQ ID NO: 799, SEQ ID NO: 434, SEQ ID NO: 743, SEQ ID NO: 804, and SEQ ID NO: 733.
In yet another embodiment, the H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof involved in nucleotide metabolism selected from the group consisting of SEQ ID NO: 1512, SEQ ID NO: 1515, SEQ ID NO: 1642, SEQ ID NO: 1668, SEQ ID NO: 1816, SEQ ID NO: 1845, SEQ ID NO: 1865, SEQ ID NO: 1866, SEQ ID NO: 1886, SEQ ID NO: 1509, SEQ ID NO: 1510, SEQ ID NO: 826, -26- SEQ ID NO: 562, SEQ ID NO: 420, SEQ ID NO: 664, SEQ ID NO: 850, SEQ ID NO: 857, SEQ ID NO: 861, SEQ ID NO: 872, SEQ ID NO: 544, SEQ ID NO: 830, and SEQ ID NO: 446.
In yet a further embodiment, the H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof involved in carbohydrate metabolism selected from the group consisting of SEQ ID NO: 1531, SEQ ID NO: 1579, SEQ ID NO: 1584, SEQ ID NO: 1662, SEQ ID NO: 1703, SEQ ID NO: 1704, SEQ ID NO: 1737, SEQ ID NO: 1740, SEQ ID NO: 1742, SEQ ID NO: 1754. SEQ ID NO: 1847, SEQ ID NO: 1447, SEQ ID NO: 397, SEQ ID NO: 699, SEQ ID NO: 459, SEQ ID NO: 509, SEQ ID NO: 818, SEQ ID NO: 488, SEQ ID NO: 438, SEQ ID NO: 831, SEQ ID NO: 667, SEQ ID NO: 429, SEQ ID NO: 680, and SEQ ID NO: 597.
In another embodiment, the H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof involved in cofactor metabolism selected from the group consisting of SEQ ID NO: 1546, SEQ ID NO: 1607, SEQ ID NO: 1609, SEQ ID NO: 1610, SEQ ID NO: 1728, SEQ ID NO: 1489, SEQ ID NO: 460. SEQ ID NO: 709, SEQ ID NO: 822, SEQ ID NO: 466, SEQ ID NO: 584, and SEQ ID NO: 388.
In another embodiment, the H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof involved in lipid metabolism selected from the group consisting of SEQ ID NO: 1708, SEQ ID NO: 1808, SEQ ID NO: 1887, 20 SEQ ID NO: 631, SEQ ID NO: 787, and SEQ ID NO: 532.
In another embodiment, the H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof involved in mRNA translation and ribosome biogenesis selected from the group consisting of SEQ ID NO: 1498, SEQ ID NO: 1506, SEQ ID NO: 1592, SEQ ID NO: 1678, SEQ ID NO: 1778, SEQ ID NO: 1863, SEQ ID NO: 619. SEQ ID NO: 723, SEQ ID NO: 641, SEQ ID NO: 698. SEQ ID NO: 630, and SEQ ID NO: 869.
In another embodiment, the H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof involved in genome replication, transcription, recombination and repair selected from the group consisting of SEQ ID NO: 30 1454, SEQ ID NO: 1538, SEQ ID NO: 1567, SEQ ID NO: 1581, SEQ ID NO: 1583, SEQ ID NO: 1636, SEQ ID NO: 1639, SEQ ID NO: 1649, SEQ ID NO: 1669, SEQ ID NO: 1695, SEQ ID NO: 1757, SEQ ID NO: 1776, SEQ ID NO: 1848, SEQ ID NO: 1849, SEQ ID NO: 1858, SEQ ID NO: 1884, SEQ ID NO: 601, SEQ ID NO: 415, SEQ ID NO: 542, SEQ ID NO: 704, SEQ ID NO: 572, SEQ ID NO: 467, SEQ ID NO: 399, SEQ ID NO: 579, SEQ ID NO: 739, SEQ ID NO: 849, SEQ ID NO: 824, SEQ ID NO: 871, SEQ ID NO: 547, SEQ ID NO: 633, SEQ ID NO: 695, SEQ ID NO: 405, SEQ ID NO: 394, and SEQ ID NO: 761.
In another embodiment, the H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof involved in outer membrane or cell wall biosynthesis selected from the group consisting of SEQ ID NO: 1667, SEQ ID NO: 1690, SEQ ID NO: 1813, SEQ ID NO: 1468, SEQ ID NO: 1470. SEQ ID NO: 1811, SEQ ID NO: 574, SEQ ID NO: 596, SEQ ID NO: 832. SEQ ID NO: 651, SEQ ID NO: 867, SEQ ID NO: 614, SEQ ID NO: 401, and SEQ ID NO: 393.
In yet another embodiment, the H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori chaperone polypeptide or a fragment thereof selected from the group consisting of SEQ ID NO: 1874, SEQ ID NO: 1876, SEQ ID NO: 1825, SEQ ID NO: 413, SEQ ID NO: 835, and SEQ ID NO: 863.
Particularly preferred is a purified or isolated H. pylori secreted or periplasmic polypeptide or a fragment thereof, wherein the polypeptide is selected from the group consisting of SEQ ID NO: 1455, SEQ ID NO: 1589, SEQ ID NO: 1518, SEQ ID NO: 1529, SEQ ID NO: 1765, SEQ ID NO: 1770, SEQ ID NO: 1829, SEQ ID NO: 1556, SEQ ID NO: 1565, SEQ ID NO: 1569, SEQ ID NO: 1571. SEQ ID NO: 1574, SEQ ID NO: 1578, SEQ ID NO: 1663, SEQ ID NO: 1674, SEQ ID NO: 1676. SEQ ID NO: 1697. SEQ ID NO: 1699, SEQ ID NO: 1710, SEQ ID NO: 1715, SEQ ID NO: 1716. SEQ ID NO: 1732, SEQ ID NO: 1736, SEQ ID NO: 1745, SEQ ID NO: 1749, SEQ ID NO: 1750, SEQ ID NO: 1766, SEQ ID NO: 1767, SEQ ID NO: 1768, SEQ ID NO: 1769, SEQ ID NO: 1795, SEQ ID NO: 1802, SEQ ID NO: 1804, SEQ ID NO: 1824, SEQ ID NO: 1831, SEQ ID NO: 1838, SEQ ID NO: 1840, SEQ ID NO: 1844, SEQ ID NO: 1862. SEQ ID NO: 1879, 20 SEQ ID NO: 1882, SEQ ID NO: 1890, SEQ ID NO: 1494, SEQ ID NO: 1634, SEQ ID NO: 1635, SEQ ID NO: 1647, SEQ ID NO: 1648, SEQ ID NO: 1654, SEQ ID NO: 1446, SEQ ID NO: 1449, SEQ ID NO: 1452, SEQ ID NO: 1473, SEQ ID NO: 1474, SEQ ID NO: 1480, SEQ ID NO: 1491, SEQ ID NO: 1502, SEQ ID NO: 1513. SEQ ID NO: 1605, SEQ ID NO: 1771, SEQ ID NO: 1526, SEQ ID NO: 1557, SEQ ID NO: 1560, SEQ ID NO: 1585, SEQ ID NO: 1672. SEQ ID NO: 1677, SEQ ID NO: 1686, SEQ ID NO: 1752.
SEQ ID NO: 1762, SEQ ID NO: 1777, SEQ ID NO: 1792, SEQ ID NO: 1805, SEQ ID NO: 1815, SEQ ID NO: 1817, SEQ ID NO: 1827, SEQ ID NO: 1842, SEQ ID NO: 1846, SEQ ID NO: 1896, SEQ ID NO: 1530, SEQ ID NO: 1637, SEQ ID NO: 1461, SEQ ID 0 NO: 1467, SEQ ID NO: 1623, SEQ ID NO: 1625, SEQ ID NO: 530, SEQ ID NO: 708, 30 SEQ ID NO: 414, SEQ ID NO: 694, SEQ ID NO: 703. SEQ ID NO: 721, SEQ ID NO: 749, SEQ ID NO: 685, SEQ ID NO: 444, SEQ ID NO: 606, SEQ ID NO: 582, SEQ ID NO: 621, SEQ ID NO: 868, SEQ ID NO: 666, SEQ ID NO: 408, SEQ ID NO: 538, SEQ ID NO: 573, SEQ ID NO: 639, SEQ ID NO: 668, SEQ ID NO: 524, SEQ ID NO: 422, SEQ ID NO: 819, SEQ ID NO: 611, SEQ ID NO: 674, SEQ ID NO: 577, SEQ ID NO: 663, SEQ ID NO: 558, SEQ ID NO: 794, SEQ ID NO: 564, SEQ ID NO: 592, SEQ ID NO: 814, SEQ ID NO: 398, SEQ ID NO: 767, SEQ ID NO: 425, SEQ ID NO: 659. SEQ ID NO: 517, SEQ ID NO: 539, SEQ ID NO: 475, SEQ ID NO: 615, SEQ ID NO: 665, SEQ ID NO: 607, SEQ ID NO: 598, SEQ ID NO: 759. SEQ ID NO: 752. SEQ ID NO: 595, SEQ ID NO: 686, SEQ ID NO: 528. SEQ ID NO: 705. SEQ ID NO: 828, SEQ ID NO: 403, SEQ ID NO: 561, SEQ ID NO: 500, SEQ ID NO: 491. SEQ ID NO: 846. SEQ ID NO: 732. SEQ ID NO: 778, SEQ ID NO: 751. SEQ ID NO: 744, SEQ ID NO: 504, SEQ ID NO: 419, SEQ ID NO: 792, SEQ ID NO: 825, SEQ ID NO: 756. SEQ ID NO: 519. SEQ ID NO: 870, SEQ ID NO: 777, SEQ ID NO: 808, SEQ ID NO: 506. SEQ ID NO: 864, SEQ ID NO: 655, SEQ ID NO: 407, SEQ ID NO: 427, SEQ ID NO: 774, SEQ ID NO: 797, SEQ ID NO: 688, SEQ ID NO: 815, SEQ ID NO: 718. SEQ ID NO: 859, SEQ ID NO: 775, SEQ ID NO: 874, SEQ ID NO: 543, SEQ ID NO: 878, SEQ ID NO: 594, SEQ ID NO: 610, and SEQ ID NO: 600.
Particularly preferred is a purified or isolated H. pylori surface or membrane polypeptide or a fragment thereof, wherein the polypeptide is selected from the group consisting of SEQ ID NO: 1511. SEQ ID NO: 1561, SEQ ID NO: 1563, SEQ ID NO: 1681, SEQ ID NO: 1711, SEQ ID NO: 1731, SEQ ID NO: 1743, SEQ ID NO: 1747, SEQ ID NO: 1758, SEQ ID NO: 1893, SEQ ID NO: 1895, SEQ ID NO: 1573, SEQ ID NO: 1705, SEQ ID NO: 1707, SEQ ID NO: 1723, SEQ ID NO: 1726, SEQ ID NO: 1760. SEQ ID NO: 1764, SEQ ID NO: 1798. SEQ ID NO: 1803, SEQ ID NO: 1807, SEQ ID NO: 1889, SEQ ID NO: 1892. SEQ ID NO: 1460, SEQ ID NO: 1477, SEQ ID NO: 1499. SEQ ID NO: 1514, SEQ ID NO: 1641, SEQ ID NO: 1534, SEQ ID NO: 1564, SEQ ID NO: 1673, SEQ ID NO: 1746, SEQ ID NO: 1794, SEQ ID NO: 1843, SEQ ID NO: 1894, SEQ ID NO: 1536, SEQ ID NO: 1544, SEQ ID NO: 1568, SEQ ID NO: 1572, SEQ ID NO: 1582, 20 SEQ ID NO: 1738, SEQ ID NO: 1891, SEQ ID NO: 1660, SEQ ID NO: 1793, SEQ ID NO: 1832, SEQ ID NO: 1841. SEQ ID NO: 1860, SEQ ID NO: 1486, SEQ ID NO: 1465, SEQ ID NO: 1539, SEQ ID NO: 1693, SEQ ID NO: 1629, SEQ ID NO: 1540, SEQ ID NO: 1791, SEQ ID NO: 1525. SEQ ID NO: 1558, SEQ ID NO: 1655, SEQ ID NO: 1517, SEQ ID NO: 875. SEQ ID NO: 676. SEQ ID NO: 801, SEQ ID NO: 860, SEQ ID NO: 747. SEQ ID NO: 529. SEQ ID NO: 387, SEQ ID NO: 391, SEQ ID NO: 515, SEQ ID NO: 625, SEQ ID NO: 568. SEQ ID NO: 454, SEQ ID NO: 800, SEQ ID NO: 499, SEQ ID NO: 779, SEQ ID NO: 648. SEQ ID NO: 643, SEQ ID NO: 537, SEQ ID NO: 511, SEQ ID NO: 616. SEQ ID NO: 829. SEQ ID NO: 546, SEQ ID NO: 780, SEQ ID NO: 553, SEQ ID NO: 549, SEQ ID NO: 410, SEQ ID NO: 608, SEQ ID NO: 513, SEQ ID 30 NO: 656, SEQ ID NO: 845. SEQ ID NO: 563, SEQ ID NO: 570, SEQ ID NO: 805, SEQ ID NO: 851, SEQ ID NO: 423. SEQ ID NO: 810, SEQ ID NO: 604, SEQ ID NO: 636, SEQ ID NO: 757, SEQ ID NO: 412. SEQ ID NO: 816, SEQ ID NO: 771, SEQ ID NO: 418, SEQ ID NO: 662. SEQ ID NO: 512, SEQ ID NO: 679, SEQ ID NO: 605, SEQ ID NO: 421, SEQ ID NO: 552. SEQ ID NO: 576, SEQ ID NO: 571, SEQ ID NO: 725, SEQ ID NO: 565, SEQ ID NO: 717. SEQ ID NO: 536, SEQ ID NO: 647, SEQ ID NO: 501, SEQ ID NO: 838, SEQ ID NO: 428. SEQ ID NO: 494, SEQ ID NO: 479, SEQ ID NO: 711, SEQ ID NO: 722 ,SEQ ID NO: 645, SEQ ID NO: 670, SEQ ID NO: 746, SEQ ID NO: 493, SEQ ID NO: 540, SEQ ID NO: 612, SEQ ID NO: 629, SEQ ID NO: 484, SEQ ID NO: 485, SEQ ID NO: 486. SEQ ID NO: 433, SEQ ID NO: 385, and SEQ ID NO: 409.
-29- In one embodiment, the H. pylori surface or membrane polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof having at least one membrane spanning region selected from the group consisting of SEQ ID NO: 1511, SEQ ID NO: 1561, SEQ ID NO: 1563, SEQ ID NO: 1681, SEQ ID NO: 1711, SEQ ID NO: 1731. SEQ ID NO: 1743. SEQ ID NO: 1747, SEQ ID NO: 1758, SEQ ID NO: 1893, SEQ ID NO: 1895, SEQ ID NO: 875, SEQ ID NO: 676, SEQ ID NO: 801, SEQ ID NO: 860. SEQ ID NO: 747, SEQ ID NO: 529, SEQ ID NO: 387, SEQ ID NO: 391, SEQ ID NO: 515, SEQ ID NO: 625, SEQ ID NO: 568, SEQ ID NO: 454, SEQ ID NO: 800. SEQ ID NO: 499, SEQ ID NO: 779, and SEQ ID NO: 385.
In another embodiment, the H. pylori surface or membrane polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof having at least two membrane spanning regions selected from the group consisting of SEQ ID NO: 1573, SEQ ID NO: 1705, SEQ ID NO: 1707, SEQ ID NO: 1723, SEQ ID NO: 1726, SEQ ID NO: 1760, SEQ ID NO: 1764. SEQ ID NO: 1798, SEQ ID NO: 1803. SEQ ID NO: 1807. SEQ ID NO: 1889. SEQ ID NO: 1892, SEQ ID NO: 1460, SEQ ID NO: 1477, SEQ ID NO: 1499, SEQ ID NO: 1514, SEQ ID NO: 1641, SEQ ID NO: 648. SEQ ID NO: 643, SEQ ID NO: 537, SEQ ID NO: 511, SEQ ID NO: 616, SEQ ID NO: 829, SEQ ID NO: 546, SEQ ID NO: 780, SEQ ID NO: 553, SEQ ID NO: 549, SEQ ID NO: 410, SEQ ID NO: 608, SEQ ID NO: 513, SEQ ID NO: 656, SEQ ID NO: 845. SEQ ID NO: 563, SEQ ID NO: 20 570, SEQ ID NO: 805, and SEQ ID NO: 851.
In yet another embodiment, the H. pylori surface or membrane polypeptide or a ::fragment thereof is an H. pylori polypeptide or a fragment thereof having at least three membrane spanning regions selected from the group consisting of SEQ ID NO: 1534, SEQ ID NO: 1564, SEQ ID NO: 1673, SEQ ID NO: 1746, SEQ ID NO: 1794, SEQ ID NO: 1843, SEQ ID NO: 1894, SEQ ID NO: 423, SEQ ID NO: 810. SEQ ID NO: 604. SEQ ID 636, SEQ ID NO: 757, SEQ ID NO: 412, and SEQ ID NO: 816.
S. In yet a further embodiment, the H. pylori surface or membrane polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof having at least four membrane spanning regions selected from the group consisting of SEQ ID NO: 1536, SEQ ID NO: 1544, SEQ ID NO: 1568, SEQ ID NO: 1572, SEQ ID NO: 1582. SEQ ID NO: 1738, SEQ ID NO: 1891, SEQ ID NO: 1660, SEQ ID NO: 771, SEQ ID NO: 418, SEQ ID NO: 662, SEQ ID NO: 512, SEQ ID NO: 679, SEQ ID NO: 605, SEQ ID NO: 421, SEQ ID NO: 552, SEQ ID NO: 576, SEQ ID NO: 571.
In another embodiment, the H. pylori surface or membrane polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof having at least five membrane spanning regions selected from the group consisting of SEQ ID NO: 1793, SEQ ID NO: 1832, SEQ ID NO: 1841, SEQ ID NO: 1860, SEQ ID NO: 1486. SEQ ID NO: 725, SEQ ID NO: 565, SEQ ID NO: 717, SEQ ID NO: 536, SEQ ID NO: 647, and SEQ ID NO: 409.
In another embodiment, the H. pylori surface or membrane polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof having at least six membrane spanning regions selected from the group consisting of SEQ ID NO: 1465, SEQ ID NO: 1539, SEQ ID NO: 1693, SEQ ID NO: 1629, SEQ ID NO: 501, SEQ ID NO: 838, SEQ ID NO: 428, SEQ ID NO: 494. SEQ ID NO: 479. SEQ ID NO: 711. and SEQ ID NO: 722.
In yet another embodiment, the H. pylori surface or membrane polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof having at least seven membrane spanning regions selected from the group consisting of SEQ ID NO: 1540, SEQ ID NO: 1791, SEQ ID NO: 1525, SEQ ID NO: 1558, SEQ ID NO: 1655, SEQ ID NO: 1517, SEQ ID NO: 645, SEQ ID NO: 670, SEQ ID NO: 746, SEQ ID NO: 493, SEQ ID NO: 540, SEQ ID NO: 612, SEQ ID NO: 629, SEQ ID NO: 484, SEQ ID NO: 485, SEQ ID NO: 486, and SEQ ID NO: 433.
In another aspect, the invention pertains to any individual H. pylori polypeptide member or nucleic acid encoding such a member from the above-identified groups of H.
pylori polypeptides.
In another aspect, the invention features nucleic acids capable of binding mRNA of H. pylori. Such nucleic acid is capable of acting as antisense nucleic acid to control the translation of mRNA of H. pylori. A further aspect features a nucleic acid which is capable 20 of binding specifically to an H. pylori nucleic acid. These nucleic acids are also referred to herein as complements and have utility as probes and as capture reagents.
In another aspect, the invention features an expression system comprising an open reading frame corresponding to H. pylori nucleic acid. The nucleic acid further comprises a control sequence compatible with an intended host. The expression system is useful for making polypeptides corresponding to H. pylori nucleic acid.
In another aspect, the invention features a cell transformed with the expression system to produce H. pylori polypeptides.
In another aspect, the invention features a method of generating antibodies against H. pylori polypeptides which are capable of binding specifically to H. pylori polypeptides.
30 Such antibodies have utility as reagents for immunoassays to evaluate the abundance and distribution ofH. pylori-specific antigens.
In another aspect,'the invention features a method of generating vaccines for immunizing an individual against H. pylori. The method includes: immunizing a subject with an H. pylori polypeptide, a surface or secreted polypeptide, or active portion thereof, and a pharmaceutically acceptable carrier. Such vaccines have therapeutic and prophylactic utilities.
In another aspect, the invention provides a method for generating a vaccine comprising a modified immunogenic H. pylori polypeptide, a surface or secreted polypeptide, or active portion thereof, and a pharmacologically acceptable carrier.
-31- In another aspect, the invention features a method of evaluating a compound, e.g. a polypeptide, a fragment of a host cell polypeptide, for the ability to bind an H. pylori polypeptide. The method includes: contacting the candidate compound with an H. pylori polypeptide and determining if the compound binds or otherwise interacts with an H. pylori polypeptide. Compounds which bind H. pylori are candidates as activators or inhibitors of the bacterial life cycle. These assays can be performed in vitro or in vivo.
In another aspect, the invention features a method of evaluating a compound, e.g. a polypeptide, a fragment of a host cell polypeptide, for the ability to bind an H. pylori nucleic acid, DNA or RNA. The method includes: contacting the candidate compound with an H. pylori nucleic acid and determining if the compound binds or otherwise interacts with an H. pylori polypeptide. Compounds which bind H. pylori are candidates as activators or inhibitors of the bacterial life cycle. These assays can be performed in vitro or in vivo.
The invention features H. pylori polypeptides, preferably a substantially pure preparation of an H. pylori polypeptide. or a recombinant H pylori polypeptide. In preferred embodiments: the polypeptide has biological activity; the polypeptide has an amino acid sequence at least 60%, 70%, 80%, 90%, 95%, 98%, or 99% identical to an amino acid sequence of the invention contained in the Sequence Listing, preferably it has about 65% sequence identity with an amino acid sequence of the invention contained in the 20 Sequence Listing, and most preferably it has about 92% to about 99% sequence identity with an amino acid sequence of the invention contained in the Sequence Listing; the polypeptide has an amino acid sequence essentially the same as an amino acid sequence of the invention contained in the Sequence Listing; the polypeptide is at least 5, 10, 20, 100. or 150 amino acid residues in length; the polypeptide includes at least 5, preferably at least 10, more preferably at least 20, more preferably at least 50, 100, or 150 contiguous amino acid residues of the invention contained in the Sequence Listing. In yet another preferred embodiment, the amino acid sequence which differs in sequence identity by about 7% to about 8% from the H. pylori amino acid sequences of the invention contained in the Sequence Listing is also encompassed by the invention.
30 In preferred embodiments: the H. pylori polypeptide is encoded by a nucleic acid of the invention contained in the Sequence Listing, or by a nucleic acid having at least 70%, 80%, 90%, 95%. 98%. or 99% homology with a nucleic acid of the invention contained in the Sequence Listing.
In a preferred embodiment, the subject H. pylori polypeptide differs in amino acid sequence at 1, 2, 3, 5, 10 or more residues from a sequence of the invention contained in the Sequence Listing. The differences, however, are such that the H. pylori polypeptide exhibits an H. pylori biological activity, the H. pylori polypeptide retains a biological activity of a naturally occurring H. pylori enzyme.
I
-32- In preferred embodiments, the polypeptide includes all or a fragment of an amino acid sequence of the invention contained in the Sequence Listing; fused, in reading frame, to additional amino acid residues, preferably to residues encoded by genomic DNA 5' or 3' to the genomic DNA which encodes a sequence of the invention contained in the Sequence Listing.
In yet other preferred embodiments, the H. pylori polypeptide is a recombinant fusion protein having a first H. pylori polypeptide portion and a second polypeptide portion, a second polypeptide portion having an amino acid sequence unrelated to H.
pylori. The second polypeptide portion can be, any of glutathione-S-transferase, a DNA binding domain, or a polymerase activating domain. In preferred embodiment the fusion protein can be used in a two-hybrid assay.
Polypeptides of the invention include those which arise as a result of alternative transcription events, alternative RNA splicing events, and alternative translational and postranslational events.
The invention also encompasses an immunogenic component which includes an H.
pylori polypeptide in an immunogenic preparation; the immunogenic component being capable of eliciting an immune response specific for the H. pylori polypeptide, a humoral response, an antibody response, or a cellular response. In preferred embodiments, the immunogenic component comprises at least one antigenic determinant from a 20 polypeptide of the invention contained in the Sequence Listing.
In another aspect, the invention provides a substantially pure nucleic acid having a .o nucleotide sequence which encodes an H. pylori polypeptide. In preferred embodiments: the encoded polypeptide has biological activity; the encoded polypeptide has an amino acid sequence at least 60%, 70%, 80%, 90%, 95%, 98%, or 99% homologous to an amino acid sequence of the invention contained in the Sequence Listing; the encoded polypeptide has an amino. acid sequence essentially the same as an amino acid sequence of the invention contained in the Sequence Listing; the encoded polypeptide is at least 5, 10, 20, 50, 100, or 150 amino acids in length; the encoded polypeptide comprises at least 5, preferably at least more preferably at least 20, more preferably at least 50, 100, or 150 contiguous amino acids of the invention contained in the Sequence Listing.
In preferred embodiments: the nucleic acid of the invention is that contained in the :"Sequence Listing; the nucleic acid is at least 60%, 70%, 80%, 90%, 95%, 98%, or 99% homologous with a nucleic acid sequence of the invention contained in the Sequence Listing.
In a preferred embodiment, the encoded H. pylori polypeptide differs by amino acid substitution, addition or deletion of at least one amino acid residue) in amino acid sequence at 1, 2, 3, 5, 10 or more residues, from a sequence of the invention contained in the Sequence Listing. The differences, however, are such that: the H. pylori encoded I I polypeptide exhibits a H. pylori biological activity, the encoded H. pylori enzyme retains a biological activity of a naturally occurring H. pylori.
In preferred embodiments, the encoded polypeptide includes all or a fragment of an amino acid sequence of the invention contained in the Sequence Listing; fused, in reading frame, to additional amino acid residues, preferably to residues encoded by genomic DNA or 3' to the genomic DNA which encodes a sequence of the invention contained in the Sequence Listing.
In preferred embodiments, the subject H. pylori nucleic acid will include a transcriptional regulatory sequence, e.g. at least one of a transcriptional promoter or transcriptional enhancer sequence, operably linked to the H. pylori gene sequence, to render the H. pylori gene sequence suitable for expression in a recombinant host cell.
In yet a further preferred embodiment, the nucleic acid which encodes an H. pylori polypeptide of the invention, hybridizes under stringent conditions to a nucleic acid probe corresponding to at least 8 consecutive nucleotides of the invention contained in the Sequence Listing; more preferably to at least 12 consecutive nucleotides of the invention contained in the Sequence Listing; more preferably to at least 20 consecutive nucleotides of the invention contained in the Sequence Listing; more preferably to at least 40 consecutive nucleotides of the invention contained in the Sequence Listing.
In a preferred embodiment, the nucleic acid encodes a peptide which differs by at 20 least one amino acid residue from the sequences of the invention contained in the Sequence S Listing.
In a preferred embodiment, the nucleic acid differs by at least one nucleotide from a S nucleotide sequence of the invention contained in the Sequence Listing which encodes amino acids of the invention contained in the Sequence Listing.
25 In another aspect, the invention encompasses: a vector including a nucleic acid which encodes an H. pylori polypeptide or an H. pylori polypeptide variant as described herein; a host cell transfected with the vector; and a method of producing a recombinant H.
pylori polypeptide or H. pylori polypeptide variant; including culturing the cell, in a cell culture medium, and isolating the H. pylori or H. pylori polypeptide variant, from the cell or from the cell culture medium.
In another aspect, the invention features, a purified recombinant nucleic acid having at least 50%, 60%, 70%; 80%, 90%, 95%, 98%, or 99% homology with a sequence of the invention contained in the Sequence Listing.
The invention also provides a probe or primer which includes a substantially purified oligonucleotide. The oligonucleotide includes a region of nucleotide sequence which hybridizes under stringent conditions to at least 10 consecutive nucleotides of sense or antisense sequence of the invention contained in the Sequence Listing, or naturally occurring mutants thereof. In preferred embodiments, the probe or primer further includes a label group attached thereto. The label group can be, a radioisotope. a fluorescent -34compound. an enzyme, and/or an enzyme co-factor. Preferably the oligonucleotide is at least 10 and less than 20, 30. 50. 100, or 150 nucleotides in length.
The invention further provides nucleic acids, RNA or DNA. encoding a polypeptide of the invention. This includes double stranded nucleic acids as well as coding and antisense single strands.
The H. pylori strain, from which genomic sequences have been sequenced. has been deposited in the American Type Culture Collection(ATCC 55679) as strain HP-J99.
Included in the invention are: allelic variations; natural mutants; induced mutants; proteins encoded by DNA that hybridizes under high or low stringency conditions to a nucleic acid which encodes a polypeptide of the invention contained in the Sequence Listing (for definitions of high and low stringency see Current Protocols in Molecular Biology, John Wiley Sons, New York, 1989, 6.3.1 6.3.6, hereby incorporated by reference); and, polypeptides specifically bound by antisera to H. pylori polypeptides.
especially by antisera to an active site or binding domain ofH. pylori polypeptide. The invention also includes fragments, preferably biologically active fragments. These and other polypeptides are also referred to herein as H. pylori polypeptide analogs or variants.
Putative functions have been determined for several of the H. pylori polypeptides of the invention, as shown in Table 1.
.'.'.Accordingly, uses of the claimed H. pylori polypeptides in these identified functions 20 are also within the scope of the invention.
In addition, the present invention encompasses H. pylori polypeptides characterized as shown in Table 1 below, including: H. pylori cell envelope proteins, H. pylori periplasmic/secreted proteins, H. pylori cytoplasmic proteins, and other H. pylori surface and membrane proteins. Members of these groups were identified by BLAST homology 25 searches and by searches for secretion signal or transmembrane protein motifs.
(Polypeptides in the same'row of Table 1, rows 1 and 3. or rows 2 and 4. are related to one another as described in Table 3 below.) *o* TABLE I TABLE OF FUNCTIONAL GROUPS nt aa flt aa ORF Name SeqID SeqID ORE Name SeqID SeqID Row 1 23 4 012ge201orf34 1071 1522 2 945837.aa 944 675 Tl gel10401orf5 1021 1552 269987.aa 2107 518 O2eI2O32orfll 1135 1586 6 289090.aa 894 464 02geI23orf11 1276 1727 229283.aa 943 672 06cp20302orf12 101 1601 2 95527.aa 203 640 07ge20151orf27 1187 1638 l1795505.aa 18 404 07ge I151orf27 1187 1638 3611066.aa 207 518 Ogep2llO2orfl 1192 156 16049.aa 59 389 72e 2910341orfl6 136 1827 2 4883.aa 993 635 h6p2lO0lorfS2 1379 1801 91527.aa 92 877 :9 hpelll22orf27 1399 168 2 5478375.aa 94 67 hp3ell1l68orf2 1403 1854 16984442.aa 899 477 *hpelIlIl22orfS 1400 1851 3942217.aa 302 772 0 7ge20415orf34 19 1640 2 6380318.aa 215 658 Inner membrane proteins 0 Ocel110 16orfl 1002 1453 O9ap Il4O6orfl 4 1213 1664 16131887.aa 893 463 O9aplIl406orflS5 1214 1665 6093906.aa 984 852 O9aplIl4O6orfS 1215 1666 2082012.aa 97 503 IlceI 6O3orfl6 1234 1685 1204418.aa 22 411 1 IceI 6O3orfl 6 1234 1685 14455461.aa 49 441 IlIcelIl6O3orf25 1236 1687 4035783.aa 309 782 IlIceI 6O3orf6 1237 1688 2 3915877.aa 150 575 09cp10502orf22 1224 1675 30730068.aa 240 691 09cp10502orf22 1224 1675 3385833.aa 957 724 11lgplIO9O4orf29 1251 1702 14713512.aa 57 452 12apl0324orf2 1262 1713 10353192.aa 2 386 O6cp2O3O2orflO0 1149 1600 203192.aa 92 497 O9ap2O8O2orfS 1220 1671 32704686.aa 255 712 11lgel0309orfl 4 1240 1691 24222885.aa 164 591 11 gel0309orfl 4 1240 1691 2548562.aa 201 638 O6gplIO4O9orfl 1164 1615 34666680.aa 278 740 O6gplIO4O9orf8 1165 1616 3203142.aa 245 697 a a a a. a a. a a. a hp3eIIl68orf29 1404 1855 23853165.aa 921 569 O6cplIIII8orf6 1144 1595 16412593.aa 896 470 O6cplIII18orf6 1144 1595 32236462.aa 248 700 07ee20513orf28 1182 1633 24132293.aa 159 586 07ee20513orf28 1182 1633 486075.aa 979 823 O6eplO306orfl2 1157 1608 24651083.aa 194 627 O6eplO306orf3 1160 1611 24651083.aa 194 627 06ep10306orf3 1160 1611 30089217.aa 946 684 13ep12003orf20 1300 1751 2 3493756.aa 916 551 14geI0705orfl1 1321 1772 1 7 086587.aa 76 478 14geI0705orfl 1 1321 1772 21486677.aa 905 508 14ge10705orfl1 1321 1772 23468781.aa 914 545 14ge10705orfl 1 1321 1772 24708129.aa 931 628 l4gpII82Oorfl3 1323 1774 14494077.aa 50 443 l4gpl I 82Oorfl 3 1323 1774 3242337.aa 250 702 l4gpIl 82Oorfi 3 1323 1774 3962777.aa 969 776 l4gpl2Olorfl2 1329 1780 15824052.aa 66 461 l4gpl2OI1orfl2 1329 1780 34489543.aa 275 737 l4gpl2Olorfl6 1332 1783 4698838.aa 330 809 27ze 103 5 1 orf1 7 1345 1796 25605166.aa 204 642 29zp 10241orfl4 1358 1809 9776562.aa 383 879 hplpl3947orf2 1375 1826 3953143.aa 303 773 hp4pl 1352orf4 1417 1868 16406265.aa 70 468 13apI1517orf20 1283 1734 5267037.aa 983 842 16ae1ll3orfl 1335 1786 423131.aa 972 788 hp1p13922orf22 1368 1819 24611590.aa 929 624 07ee 162Oorf2 1179 1630 423131.aa 972 788 12ae 10622orf9 1255 1706 259665.aa 936 644 12ae 10622orf9 1255 1706 34097707.aa 267 727 l2aeI1404orfl 5 1258 1709 24806290.aa 197 631 O2celO213orfl4 1044 1495 14645905.aa 55 450 12geO305orf5 1273 1724 14642202.aa 54 448 Olxe2l7l7orf18 1024 1475 26 261040.aa 210 653 A.3. Transporters 09ap20802orf27 1219 1670 2 0 032561.aa 90 495 l2gelO305orfl6 1274 1725 11132778.aa 15 400 O9ae 11601orfl4 1210 1661 23439633.aa 913 541 O9ae 11601orfl4 1210 1661 29302003.aa 227 673 hpel 1726orf7 1422 1873 179677.aa 79 482 l4ce Ill3orfl 1302 1753 24609593.aa 191 622 l4cplOIl9orfl2 1308 1759 30662792.aa 238 689 l4cp1I 9orfl5 1310 1761 34427317.aa 274 736 l4gpI2015orfl4 1331 1782 12617677.aa 27 417 hp5el544Oorfl6 1432 1883 33203192.aa 258 716 IS44Oorfl 6 1432 1883 36573502.aa 295 762 O2ceI1022orf7 1052 1503 1071890.aa 10 395 O4ep 10811orf4 1091 1542 24215.aa 160 587 -37- O4ep 10811orf4 1091 1542 289711.aa 225 669 hp5eIl726orf4 1421 1872 36203402.aa 964 758 02ge201 6orf28 1069 1520 24238762.aa 166 593 0 ce 1513orf2l 1005 1456 1464715.aa 56 451 Olcel 15l3orf2l 1005 1456 4882763.aa 980 827 01ce I668orl0 1007 1458 207817.aa 903 502 06gp 11202orf7 1166 1617 33399142.aa 261 719 07cp21714orf13 1177 1628 16406581.aa 71 469 07gp11807orf25 1193 1644 3319687.aa 955 715 O7gp 1807orf8 1206 1657 5875152.aa 361 847 07gp 11807orf9 1207 1658 14714687.aa 58 453 l4ce20219orfl 1304 1755 22441050.aa 114 527 14ce20219orf2 1305 1756 26258562.aa 940 652 27ze10351orfl8 1346 1797 35345228.aa 960 745 27ze10351orf24 1348 1799 23728388.aa 144 567 27ze10351orf29 1350 1801 5878208.aa 362 848 O2ae 161orfll 1032 1483 13726562.aa 40 430 O2ae 116lorfll 1032 1483 35428912.aa 285 748 O2ceI1022orf8 1053 1504 10723412.aa 11 396 O2ceI1022orf8 1053 1504 24218968.aa 161 588 Q2ce 11022orft 1053 1504 4455467.aa 974 795 03eel 1215orf29 1081 1532 22265691.aa 111 523 11911orf4l 1124 1575 4338438.aa 316 791 hp2plO625orf28 1382 1833 32952.aa 257 714 hp5plS641orfl2 1437 1888 17787558.aa 78 481 12ap10324orf3 1263 1714 3906712.aa 966 765 A.4. Outer membrane proteins O7ap8O6OIorf8 1173 1624 5083193.aa 352 837 hp3el 168orf3O 1405 1856 4960952.aa 981 833 hp3plOlS6orfl12 1406 1857 24104558.aa 158 585 hp4e13394orf2 1410 1861 7116626.aa 989 865 O4ce 11617orf2 1086 1537 36126938.aa 963 764 l4gelO705orfS 1322 1773 1431462.aa 48 440 l4geI0705orf5 1322 1773 16225006.aa 68 465 12ap10324orf7 1266 1717 23531562.aa 135 555 1 3aelO712orf9 1282 1733 22379952.aa 910 526 l2geIO305orfl 1271 1722 30478562.aa 236 687 l2gelO305rfl 1271 1722 31250333.aa 241 692 07gp3ll6orf4 1208 1659 31262.aa 949 693 05cp20518orf33 1126 1577 29479681.aa 945 677 12ap 11614orf8 1270 1721 26054702.aa 207 649 I2ge2O3Oorf2 1278 1729 4721061.aa 977 812 Other cell envelope proteins hp4p 13S52orf9 1419 1870 4821082.aa 978 820 05cp2O l8orf3 1125 1576 978477.aa 994 880 07ee20513orf14 1181 1632 24220627.aa 163 590 hp4p 1352orf2 1416 1867 32705252.aa 256 713 -3 8hp4p 113 2orf2 1416 1867 '35445843.aa 287 750 O4gelIl7l3orfll1 1096 1547 24427340.aa 184 613 03eell12l5orf3O 1082 1533 141631 2.aa 45 437 O6cplIlI722orfl 5 1146 1597 23535937.aa 136 556 06cp1I1I722orf1 5 1146 1597 26366312.aa 214 657 06cp1I1I722orf1 2 1145 1596 114505.aa 16 402 05ae20220orf32 1108 1559 2461062.aa 192 623 06cp1 1722orf21 1148 1599 6828218.aa 373 862 l6aelO5O8orfl3 1337 1788 14642217.aa 892 449 l6aelOSO8orfl4 1338 1789 30703183.aa. 239 690 hp~el2982orfl4 1424 1875 1365943.aa 34 424 0lae2200lorf2 1000 1451 4826401.aa 340 821 O1xe21717orf5 1027 1478 1385937.aa 41 432 Olxe2l7l7orfS 1027 1478 4714375.aa 332 811 07ce10203orf22 1175 1626 23526667.aa 134 554 l4gpl2Ol~orfl3 1330 1781 4 698838.aa 330 809 B. CYTOPLASAMIC
PROTEINS
B. 1. Proteins involved in energy conversion 06cp1I1722orf1 6 1147 1598 10553192.aa 882 390 13ee10216orf55 1288 1739 914087.aa 382 876 l4gpl1l820orf2O 1324 1775 23475342.aa 130 547 hplIpll1244orf7 1363 1814 29500075.aa 230 678 B.2. Proteins involved in amino acid metabolism Olael2O2lorfl 997 1448 34109763.aa 269 729 0O1eel1162l1orf6 1015 1466 4177212.aa 312 786 O3ge3llO6orfl 1084 1535 26301059.aa 211 654 *04ep71403orf1 5 1094 1545 34194093.aa 959 734 04ge1 1713orf37 1099 1550 25992137.aa 938 646 9gplO9O3orf3 1229 1680 2197663 7.aa 110 522 IlIgplIO9O4orf2 7 1250 1701 31681556.aa 244 696 *l2apI 6l4orf4 1268 1719 45914063.aa 328 807 l3eel2Ol6orflO 1293 1744 30082267.aa 235 683 l6aelOSO8orf21 1339 1790 429192.aa 315 790 *hp3plO349orfl6 1408 1859 36594167.aa 296 763 hp~e15211orf22 1429 1880 4578469.aa 976 806 *hp~el544Oorfl9 1434 1885 4492217.aa 321 799 09cp10713orf29 1228 1679 1408.aa 43 434 O2aell6llorfl 1031 1482 35269000.aa 281 743 O2aelIl6l2orfl 3 1034 1485 4570262.aa 326 804 0OIcelIl6I8orfl 8 1008 1459 34189716.aa 272 733 B.3. Proteins involved in nucleotide metabolism 02cp20821 oflO0 1061 1512 4882652.aa 344 826 O2ep3O6O7orfIO 1064 1515 23598962.aa 139 562 O7ge2O4l5orf6 1191 1642 12897656.aa 30 420 09ap20802orfl 1217 1668 2738378.aa 220 664 hplpl3852orfS 1365 1816 598933.aa 364 850 [hp3ellO024orf24 1394 1845 6517040.aa. 369 857 hp4el4535orf3 1414 1865 677088.aa 372 861 hp4el4535orf4 1415 1866 867183.aa 991 872 hp~el5440orf2l 1435 1886 23442642.aa 128 544 02cp I1822orf22 1058 1509 4895327.aa 347 830 02cp1I1822orf26 1059 1510 14574201.aa 52 446 BA4. Proteins involved in carbohydrate metabolism 03ee I1215orf26 1080 1531 10737627.aa 12 397 05cp2Ol~orfS 1128 1579 32144532.aa 247 699 05cp20518orf64 1133 1584 15807794.aa 64 459 O9ael1160lo-f3 1211 1662 2149041.aa 101 509 11lgplIl422orfl 1252 1703 4787562.aa 338 818 11 gplIl422orf2 1253 1704 19541302.aa 83 488 13ee10216orf43 1286 1737 14257751.aa 46 438 13ee10216orf56 1289 1740 4897177.aa 348 831 l3eelO2l6orf9 1291 1742 2855006.aa 223 667 l4celIl159orf2 1303 1754 13723593.aa 39 429 hp3e Il16Oorfl 1 1396 1847 29557266.aa 232 680 0 1ael1142l1orfl 996 1447 24300682.aa 168 597 Proteins involved in cofactor metabolism 04gelO8l6orf2 1095 1546 1581937.aa 65 460 O6eelIO7O9orfS 1156 1607 3261306.aa 952 709 O6eplO3O6orfl3 1158 1609 485375.aa 341 822 O6eplO3O6orfl4 1159 1610 16251627.aa 69 466 12ge20305orf14 1277 1728 24089437.aa 924 584 *02ae1I1612orf26 1038 1489 10407625.aa 4 388 B.6. Proteins involved in lipid metabolism 1 2aelIl4O4orfl 4 1257 1708 24806290.aa 197 631 2 9zpI1024l1orfll1 1357 1808 422937.aa 313 787 hp~el544Oorf22 1436 1887 22667967.aa 119 532 B.7. Proteins involved in mRLNA translation and ribosome biogenesis O2celO2l3orf2 1047 1498 24500088.aa 188 619 O2cpll4O4orfil 1055 1506 33601578.aa 956 723 O6celO5l5orf4 1141 1592 25595387.aa 935 641 09cp10713orf28 1227 1678 32036462.aa. 246 698 l4gpll182OorfS 1327 1778 24803280.aa 196 630 hp4elI4522orfll1 1412 1863 785437.aa 376 869 B.8. Proteins involved in genome replication.
transcription. recombination& repair 0O1cel110 16orfi 4 1003 1454 24396937.aa 172 601 04ce1I1617orf27 1087 1538 12520952.aa 25 415 IlSO0orfI 1116 1567 23440814.aa 126 542 O5cp2OSI8orfS6 1130 1581 32431687.aa 951 704 O5cp2OSI8orf63 1132 1583 23880087.aa 147 572 O7gelIl1O4orf4 1185 1636 16305252.aa 895 467 O7ge2O4l~orf3O 1188 1639 10745275.aa 14 399 07gp1 1807orf35 1198 1649 24036302.aa 154 579 09ap20802orf22 1218 1669 34574062.aa 277 739 09ap20802orf22 1218 1669 5879160.aa 363 849 11lgelIO3O9o-f~l 1244 1695 487750.aa 342 824 14ce2l~l6orfl 1306 1757 85786.aa 378 871 14gp I1820orf27 1325 1776 23475342.aa 130 547 hp3ellO06Oorf2 1397 1848 24818802.aa 198 633 hp3ellO06Oorf'9 1398 1849 3166040.aa 243 695 hp3plOI56orf8 1407 1858 11 719687.aa 19 405 hp~el 544Oorfl 8 1433 1884 10677187.aa 9 394 hp5el544Oorfl8 1433 1884 36523442.aa 761 B.9. Proteins involved in outer membrane or cell wall biosynthesis 09aplIl4O6orf8 1216 1667 23912807.aa 149 574 09apll4O6orfS 1216 1667 24298127.aa 167 596 1llep1201llorf9 1239 1690 495312.aa 349 832 29zp10241orf7 1362 1813 26197187.aa 209 651 Olep3O520orfl6 1017 1468 7225666.aa 990 867 Olep3O520orf27 1019 1470 24441412.aa 185 614 Olep3O520orf27 1019 1470 1 1253.aa 883 401 29zp 10241 orf4 1360 1811 10675632.aa 8 393 B. 10. Chaperones hp~e 12982orfl 3 1423 1874 12343763.aa 887 413 hp~e 15211orflO0 1425 1876 50253.aa 350 835 hpll397orl 174 825 684425aa987 863 B. 11 Other cytoplasmic proteins Olxe2l7l7orfi9 1028 1479 156587.aa 63 458 *02ae1I1612orf25 1037 1488 32422343.aa 249 701 O3eell12l5orflO 1077 1528 22542803.aa 118 531 05ae20220orf99 1115 1566 23492181.aa 132 550 11lce IO9l7orfl 4 1232 1683 14313885.aa 47 439 I IlgelIO3O9orfl 5 1241 1692 21647676.aa 106 516 l2aplIl6l4orf2 1267 1718 4562712.aa 324 802 O6ge 10l1l1orfl 1163 1614 24070250.aa 155 581 *02ge20116orf22 1068 1519 22704567.aa 121 535 02ge20116orf22 1068 1519 24003758.aa 153 578 *02ge20116orf22 1068 1519 19626250.aa 87 492 O2cplIl4O4orf9 1056 1507 6517192.aa 986 858 O3gpll5l6orf6O 1032 1554 19556290.aa 842 489 O3aelO3O16orfl 1042 1555 1470.aa 900 803 O4gaIe222orfS4 1111 1562 11983829.aa 20 406 cp11911orfll1 1119 1570 10664078.aa 7 392 gp11901orf2O 1136 1587 15039062.aa 61 456 0 0** 0*e* 09 0 0 *00 0 -41- 119Olorf24 1137 1588 32600912.aa 253 707 06aelI1405orflO 1140 1591 22687687.aa 120 533 O6ceI1002orf2 1142 1593 34099062.aa 268 728 1lce10917orf9 1233 1684 391313.aa 299 769 11cpl200Gorfl 7 1238 1689 291700.aa 942 671 llgel 0309orf25 1243 1694 24406401.aa 173 602 llge10309orf56 1245 1696 244953 12.aa 187 618 1lgel0309orf66 1247 1698 24495312.aa 187 618 11gpI0904orfl2 1249 1700 29844512.aa 234 682 l2aelI1404orf9 1261 1712 22303918.aa 112 524 12ap 11614orf6 1269 1720 4562712.aa 324 802 12ge20305orf3 1279 1730 4095342.aa 971 785 13apl1517orf3l 1284 1735 15126875.aa 62 457 13ee10216orf82 1290 1741 4035262.aa 308 781 13ee12016orf24 1297 1748 16459375.aa 74 473 l4gp1201orfl 1328 1779 10009666.aa 1 384 hplpl3922orf3O 1370 1821 34089087.aa 266 726 hplpl3939orfl3 1372 1823 4766691.aa 337 817 hp2e 10911orf25 1377 1828 2035936.aa 93 498 hp2plO625orf3O 1383 1834 1411681.aa 44 436 hp2plO62orf7 1384 1835 4740887.aa 335 815 hp2p IO625orfS 1385 1836 6495137.aa 368 856 hp3elO349orfl8 1388 1839 260941.aa 208 650 hp3e II168orfl4 1401 1852 5325005.aa 358 844 hp3eI 168orfl5 1402 1853 24039587.aa 923 580 hp4p 113 52orf8 1418 1869 4040928.aa 310 783 hp4pl3402orfI 1420 1871 1256885.aa 26 416 15211 orfl 5 1427 1878 35156938.aa 279 741 02ge2OII1 rf3 3 1070 1521 14480927.aa 890 442 06cp2O3 OorfB 1151 1602 4569693.aa 325 803 07ce I 1409rf4 1176 1627 21742157.aa 109 520 Olael2O2lorf8 999 1450 23646885.aa 143 566 0lce 1513orf24 1006 1457 2 3539006.aa 918 557 01cp1171Oorf27 1012 1463 32595137.aa 252 706 Olep3O520orf2O 1018 1469 32627125.aa 953 710 O2ae 11211orfl9 1030 1481 19537968.aa 902 487 O2ae 116llorf5 1033 1484 24407533.aa 174 603 O2ce 10l4orfl 1041 1492 16440842.aa 73 472 02ce10213orf32 1049 1500 16839562.aa 898 476 O2ce 122orf2 1054 1505 3930468.aa 300 770 O2cp 11721orfl3 1057 1508 5265957.aa 356 841 O4ep 1O8llorfl 1090 1541 3907042.aa 298 768 04ge 11713orf27 1097 1548 5111308.aa 354 839 05cp2O l8orf5O 1129 1580 23573294.aa 138 560 06aellO20orf2 1139 1590 4486092.aa 319 796 O6ceI1002orf8 1143 1594 194415.aa 80 483 O6cp3O6O3orfl 1 1152 1603 24824087.aa 933 634 -42- 06ee 10207orf2 1153 1604 14572133.aa 891 445 06ee I 0709orfl 7 1155 1606 6 l36430.aa 366 853 O6eplIlI 108orf2O 1161 1612 2 2 3 7 0182.aa 113 525 O6ge1ll orfl2 1162 1613 44 91093.aa 320 798 O7ap l lIlorf3 1169 1620 2 34 9 0686.aa 915 549 O7apSO6O Iorfl0 1170 1621 5 0 7 8593.aa 351 836 07ap80601 orf2 1171 1622 2 4 2 19012.aa 162 589 O7ee2Ol3orfl 1180 1631 36 520792.aa 965 760 07gp11807orf28 1194 1645 l 6 100038.aa 67 462 07gp 11807orf29 1195 1646 4 2 6 83.aa 314 789 07gp 11807orf38 1199 1650 2 l 4 812.aa 904 507 O7gpl 1807rf4l 1200 1651 4 8 8 2 842.aa 345 828 07gp11807orf42 1201 1652 7 19606.aa 374 866 07gp 11807orf44 1202 1653 3 5 949212.aa 962 754 O7gpl 807orf54 1205 1656 34 161500.aa 270 730 l4cplO923orfl 1312 1763 24 4 92192.aa 186 617 l6aelO508orflO 1336 1787 l 4 864452.aa 60 455 27ze 10351orf25 1349 1800 87 S042.aa 379 873 29gp 10119orf6 1355 1806 l 4 094816.aa 889 435 29zp 10241orf18 1359 1810 3906937.aa 967 766 hp4eI4535orf2 1413 1864 43 4 90713.aa 973 793 hp5e15211orfl3 1426 1877 3 5163962.aa 280 742 hp5eIS21Iorf29 1430 1881 24 329712.aa 170 599 6 2 5277.aa 985 854 24 8 16915.aa 932 632 see* SECRETED OR PERIPLASMIC
PROTEINS
C. 1. Secreted or periplasmic proteins Olce1016orfl9 1004 1455 2 2 4 60468.aa 117 530 105 gp 1190 1 25 1138 1589?- 3 2 6 O9 4 03.aa 254 708 O2ge2Oll6orf2O 1067 1518 I 25 O5125.aa 24 414 O3eelI1215orfl5 1078 1529 3 157067aa 242 694 14cp 10923orf3 1314 1765 3 2 42952.aa 950 703 l4ee Il2l7orfl 1319 1770 335 95708.aa 263 721 l4eell2l1 7orfl 1319 1770 3 54 4 2513.aa 286 749 hp2e 10911orf30 1378 1829 3
O
10 0332.aa 947 685 05ae20220orfl24 1105 1556 I 457 0443.aa 51 444 05ae20220orf92 1114 1565 2 4410643.aa 177 606 O5ap2l2l6orf7 1171 1569 2 4O78837.aa 156 582 191lorfl2 1120 1571 2 46 09431.aa 190 621 11911orf27 1123 1574 7 83432.aa 375 868 O5cp20518orf4l 1127 1578 2 8 4 3 912.aa 222 666 O9ae 11601orf4 1212 1663 11 8 76 471.aa 21 408 O9cp 10502orf7 1223 1674 23438887.aa 912 538 09cp 10713orf25 1225 1676 23 9 1 2707.aa 148 573 lgel03O9orf63 1246 1697 2 5 501501.aa 202 639 11ge10309orf9 1248 1699 289077.aa 224 668 l2aelI1404orf3 1259 1710 22 303918.aa 112 524 -43- 12ap10324orf4 1264 1715 13178562.aa 32 422 12ap10324o-f5 1265 1716 4805318.aa 339 819 l3aelO712orf4 1281 1732 24416083.aa 182 611 l3apll15l7orfl 1285 1736 29386577.aa 228 674 13ee12016orf15 1294 1745 23958179.aa 152 577 13ee12016orf5 1298 1749 272058.aa 219 663 l3eel2Ol6orf8 1299 1750 23564012.aa 137 558 14cp10923orf8 1315 1766 4414000.aa 318 794 l4cpl1112l1orf6 1316 1767 23631292.aa 141 564 l4ee10308orf8 1317 1768 24230058.aa 165 592 14ee10308orf'9 1318 1769 4728193.aa 334 814 l6epl10 117orf8 1344 1795 10742963.aa 13 398 27zelO3SlorfS 1351 1802 3906963.aa 297 767 29gell Ilorfl 1353 1804 1367157.aa 35 425 hplpl3939orf9 1373 1824 26423583.aa 216 659 hp2elIl858orfS 1380 1831 21687842.aa 908 517 hp3elO349orfl17 1387 1838 2 3439055.aa 124 539 hp3e10349orf24 1389 1840 16603418.aa 75 475 hp3 elIlO24orf22 1393 1844 2445812.aa 927 615 hp3elIlO24orf22 1393 1844 2774062.aa 221 665 hp4el3394orfS 1411 1862 24411011.aa 178 607 hp~e 15211orf2I 1428 1879 24328910O.aa 169 598 hp~eIS276orfl4 1431 1882 36335436.aa 293 759 hp~pl564Iorf8 1439 1890 35837767.aa 289 752 02ce1I0213orf1 1 1043 1494 24276587.aa 926 595 O7gelIl154orf2 1183 1634 30283516.aa 948 686 O7gelIl154orf3 1184 1635 22447252.aa 115 528 07gp1I1807orf32 1196 1647 32462543.aa 251 705 07gp1I1807orf33 1197 1648 4882842.aa 345 828 9..07gp1I1807orf48 1203 1654 116018.aa 17 403 0O1aelIl4O3orfl 995 1446 23594838.aa 920 561 Olael2O2lorf7 998 1449 20415937.aa 95 500 OlcelO5l6orf2 1001 1452 1962590.aa 86 491 04 1 gpl110 16orfl 4 1022 1473 5869090.aa 360 846 Olxe2l7l7orfl2 1023 1474 34179577.aa 271 732 O2ae11211orflO0 1029 1480 3987580.aa 970 778 O2aelIl6l2orf4 1040 1491 35704718.aa 288 751 O2celO2l6orfl 1051 1502 35336707.aa 282 744 02cp20821orf12 1062 1513 20836042.aa 98 504 02cp2082lorf12 1062 1513 12698442.aa 29 419 O6eelIO7O9orfl 6 1154 1605 4339708.aa 317 792 l4eplIlIIlI orfl 1320 1771 4882318.aa 343 825 C.2. Proteins likely to be secreted or periplasmic O3ap2l82OorfS 1075 1526 36131282.aa 291 756 05ae20220orf24 1106 1557 21720017.aa 108 519 O05ae2O22Oorf5O 1109 1560 80257.aa 377 870 0Dcpg2 0 518 orf 9 1134 1585 3964593.aa 305 777 05cp20518orf9 1134 1585 4687507.aa 305 808 09cp10502orfl4 1221 1672 2111040.aa 100 506
O
9 cplO7l3orf26 1226 1677 7031343.aa 988 864 1 IcelIl603orf22 1235 1686 26306340.aa 212 655 14ce1I0720orf2 1301 1752 11 81418.aa 884 40-7 l4cpl10l1l9orfl 1311 1762 1370202.aa 37 427 14gp1I1820o-f4 1326 1777 3953952.aa 968 774 l6cp3OlO9orf6 1341 1792 4490717.aa 975 7-9-7 29gpl10 1l9orf5 1354 1805 30603402.aa 237 688 hplIplIl256orf7 1364 1815 4740887.aa 3 35 815 hp~p13868orf24 1366 1817 33397538.aa 260 718 hplpl4Ol3orf4 1376 1827 663530.aa 370 -859 hp3 elIlO24orfl 6 1391 1842 2 0173437.aa 91 496 hp3 elIlO24orfl 6 1391 1842 3 4 573431.aa 276 738 hp3 e IlO24orf6 1395 1846 4
O
6 2813.aa 311 784 hp6plO723orf7 1445 1896 24 4 0 6 401.aa 173 602 O3eell12l5of20 1079 1530 2 150290.aa 102 510 07ge20415orf22 1186 1637 3 958537.aa 304 775 0OIce Il6l8orf2O 1010 1461 8 82827.aa 380 874 0: 1 OeplIO2l6orf6 1016 1467 23 4 41078.aa 127 543 O7ap8O6Ol orfS 1172 1623 9 17200.aa 993 878 S04ge1I1713orf35 1098 1549 2 4 25 6572.aa 925 594 03ap21820orf9 1076 1527 2 4 415917.aa 181 610 O7celO2O3orfl4 1174 1625 2 4 395801.aa 171 600 OTHER SURFACE AND MEMBRANE PROTEiNS D. Proteins likely to contain a single membrane spanning region O2cp I 822orf8 1060 1511 907827.aa 381 875 05Oae2O22Oorf5l 1110 1561 2 9458178.aa 229 676 -05ae20220orf6 1112 1563 4 548792.aa 323 801 I. I* lael1O305orf4 1230 1681 6 6 96887.aa 371 860 l2aelIl4O4orf8 1260 1711 3 5417942.aa 284 747 12ge20305orf35 1280 1731 22453166.aa 116 529 B~eelIl7l8orf2 1292 1743 -1038312.aa 3 387 13eeI2OI6orfl9 1296 1747 10580417.aa 6 391 13eeI2OI6orfl9 1296 1747 21618785.aa 907 515 -14ce2l516orf3 1307 1758 24634750.aa 193 625 hp6p IO723orf2O 1442 1893 23831562.aa 145 568 hp6plO723orfS 1444 1895 14726542.aa 59 454 O2celO2l3orfl 1042 1493 4 531568.aa 322 800 02ae1I1612orf36 1039 1490 2 040717.aa 94 499 O4gelI 7I3orf4I 1100 1551 39 91067.aa 306 779 lO037799.aa 881 385 D.2. Proteins likely to contain two membrane spans O5cp11911orfl 5 1122 1573 2 6 O52137.aa 939 648 12ae I0622orfl 6 1254 1705 2 59 25.aa 205 643 l2aelIl4O4orfl 2 1256 1707 2 3 43 8840.aa 123 537
S
4 l2gelO3O5orflO 1272 1723 21503772.aa 906 511 l2gelO3O~orflO 1272 1723 24488537.aa 928 616 12ge10305orf2l 1275 1726 489057.aa 346 829 l4cpl10l1l9o-fl4 1309 1760 23473437.aa 129 546 l4cpl10l1l9orfl 4 1309 1760 40339452.aa 307 780 14cp10923orf14 1313 1764 23515833.aa 133 553 27ze10351orf22 1347 1798 23486342.aa 131 548 27ze10351orf7 1352 1803 11 924177.aa 886 410 29gpl10l1l9orf7 1356 1807 24413512.aa 179 608 hp5pl564lorfS 1438 1889 21563752.aa 104 513 hp6plO723orfl3 1441 1892 26351567.aa 213 656 0 Ice11618orfl 9 1009 1460 55843.aa 359 845 0O1xe2l7l7o-f40 1026 1477 23610905.aa 140 563 02ce10213orf23 1048 1499 23867207.aa 146 570 02cp2082 Iorf8 1063 1514 4572168.aa 327 805 07ge20415orf39 1190 1641 5993958.aa 365 851 D.3. Proteins likely to contain 3 membrane spanning regions O3gelO5O5orfl4 1083 1534 1364378.aa 33 423 05ae20220orf88 1113 1564 4708337.aa 331 810 09cplO5O2orfl6 1222 1673 24409577.aa 175 604 l3eel2Ol6orfl8 1295 1746 25398250.aa 200 636 l6epl10l1l7orfl 1343 1794 36134661.aa 292 757 hp3 e IlO24orfI 7 1392 1843 1206675.aa 23 412 hp6p10723orf43 1443 1894 4744128.aa 336 816 DA4. Proteins likely to contain 4 membrane spanning regions O3xe Il2l5orfS 1085 1536 3933437.aa 301 771 04ep71403orf12 1093 1544 12694087.aa 28 418 O5aplIl1O0orflO0 1117 1568 26758437.aa 941 662 05cp11911 orfl 3 1121 1572 21511555.aa 103 512 O5cp11911orfl3 1121 1572 29531590.aa 231 679 05cp20518orf61 1131 1582 24409641I.aa 176 605 l3eelO2l6orfS 1287 1738 12969218.aa 31 421 B~eelO02l6orfS 1287 1738 23494043.aa 917 552 hp~pl564lorf9 1440 1891 23945317.aa 151 576 O9ae11601orflI1 1209 1660 23867687.aa 922 571 Proteins likely to contain 5 membrane spanning regions l6epl10l1I7orf6 1342 1793 hp2plO625orfl4 1381 1832 33986087.aa 265 725 hp3e10349orf25 1390 1841 23631317.aa 142 565 hp3p10349orf32 1409 1860 33218912.aa 259 717 O2aelIl6l2orfI 4 1035 1486 23437502.aa 122 536 25995917.aa 206 647 11878127.aa 885 409 D.6. Proteins likely to contain 6 membrane spanning regions 0O1cpl1171Oo-f34 1014 1465 2042312.aa 96 501 0O1cpl117l1Oorf34 1014 1465 5 083577.aa 353 838 04eplO2O6orf22 1088 1539 13704718.aa 38 428 -46- 0 4ep10206orf22 1088 1539 2 0 023400.aa 89 494 1 gel0309orfl8 1242 1693 17 089217.aa 77 479 07cp21714orfl4 1178 1629 3 2 663212.aa 954 711 07cp21714orf14 1178 1629 3360130.aa 264 722 D.7. Proteins likely to contain 7 or more membrane spanning regions 04ep10206orf23 1089 1540 2 5976418.aa 937 645 04ep 10206orf23 1089 1540 2915903.aa 226 670 16ael0508orf3 1340 1791 35360843.aa 283 746 03ap21820orfl3 1074 1525 197166.aa 88 493 03ap21820orfl3 1074 1525 234391.aa 125 540 03ap21820orfl3 1074 1525 24417212.aa 183 612 05ae20220orf31 1107 1558 24798427.aa 195 629 07gp11807orf49 1204 1655 19531291.aa 81 484 07gp11807orf49 1204 1655 19 536375.aa 901 485 02ep30607orf31 1066 1517 19536458.aa 82 486 02ep30607orf31 1066 1517 13865928.aa 42 433 [In Table 1, "nt" represents nucleotide Seq. ID number and "aa" represents amino Seq. ID number] Definitions 5 A purified or isolated polypeptide or a substantially pure preparation of a polypeptide are used interchangeably herein and, as used herein, mean a polypeptide that has been separated from other proteins, lipids, and nucleic acids with which it naturally occurs. Preferably, the polypeptide is also separated from substances, antibodies or gel matrix, polyacrylamide, which are used to purify it. Preferably, the polypeptide constitutes at least 10, 20, 50 70, 80 or 95% dry weight of the purified preparation.
Preferably, the preparation contains: sufficient polypeptide to allow protein sequencing; at least 1, 10, or 100 tg of the polypeptide; at least 1, 10, or 100 mg of the polypeptide.
A purified preparation of cells refers to, in the case of plant or animal cells, an in vitro preparation of cells and not an entire intact plant or animal. In the case of cultured cells or microbial cells, it consists of a preparation of at least 10% and more preferably of the subject cells.
A purified or isolated or a substantially pure nucleic acid, a substantially pure DNA, (are terms used interchangeably herein) is a nucleic acid which is one or both of the following: not immediately contiguous with both of the coding sequences with which it is immediately contiguous one at the 5' end and one at the 3' end) in the naturallyoccurring genome of the organism from which the nucleic acid is derived; or which is substantially free of a nucleic acid with which it occurs in the organism from which the nucleic acid is derived. The term includes, for example, a recombinant DNA which is incorporated into a vector, into an autonomously replicating plasmid or virus, or into the genomic DNA of a prokaryote or eukaryote, or which exists as a separate molecule a cDNA or a genomic DNA fragment produced by PCR or restriction endonuclease treatment) independent of other DNA sequences. Substantialry pure DNA also includes a -47recombinant DNA which is part of a hybrid gene encoding additional H. pylori DNA sequence.
A "contig" as used herein is a nucleic acid representing a continuous stretch of genomic sequence of an organism.
An "open reading frame", also referred to herein as ORF, is a region of nucleic acid which encodes a polypeptide. This region may represent a portion of a coding sequence or a total sequence and can be determined from a stop to stop codon or from a start to stop codon.
As used herein, a "coding sequence" is a nucleic acid which is transcribed into messenger RNA and/or translated into a polypeptide when placed under the control of appropriate regulatory sequences. The boundaries of the coding sequence are determined by a translation start codon at the five prime terminus and a translation stop code at the three prime terminus. A coding sequence can include but is not limited to messenger RNA, synthetic DNA, and recombinant nucleic acid sequences.
A "complement" ofa nucleic acid as used herein referes to an anti-parallel or antisense sequence that participates in Watson-Crick base-pairing with the original sequence.
A "gene product" is a protein or structural RNA which is specifically encoded by a gene.
As used herein, the term "probe" refers to a nucleic acid, peptide or other chemical entity which specifically binds to a molecule of interest. Probes are often associated with or capable of associating with a label. A label is a chemical moiety capable of detection.
Typical labels comprise dyes, radioisotopes, luminescent and chemiluminescent moieties, fluorophores, enzymes, precipitating agents, amplification sequences, and the like.
Similarly, a nucleic acid, peptide or other chemical entity which specifically binds to a molecule of interest and immobilizes such molecule is referred herein as a "capture ligand".
Capture ligands are typically associated with or capable of associating with a support such as nitro-cellulose, glass, nylon membranes, beads, particles and the like. The specificity of hybridization is dependent on conditions such as the base pair composition of the nucleotides, and the temperature and salt concentration of the reaction. These conditions are readily discemrnable to one of ordinary skill in the art using routine experimentation.
Homologous refers to the sequence similarity or sequence identity between two polypeptides or between two nucleic acid molecules. When a position in both of the two compared sequences is occupied by the same base or amino acid monomer subunit, if a position in each of two DNA molecules is occupied by adenine, then the molecules are homologous at that position. The percent of homology between two sequences is a function of the number of matching or homologous positions shared by the two sequences divided by the number of positions compared x 100. For example, if 6 of 10 of the positions in two sequences are matched or homologous then the two sequences are homologous. By way of example, the DNA sequences ATTGCC and TATGGC share homology. Generally, a comparison is made when two sequences are aligned to give maximum homology.
Nucleic acids are hybridizable to each other when at least one strand of a nucleic acid can anneal to the other nucleic acid under defined stringency conditions. Stringency of hybridization is determined by: the temperature at which hybridization and/or washing is performed; and the ionic strength and polarity of the hybridization and washing solutions. Hybridization requires that the two nucleic acids contain complementary sequences; depending on the stringency of hybridization, however, mismatches may be tolerated. Typically, hybridization of two sequences at high stingency (such as, for example, in a solution of 0.5X SSC, at 65° C) requires that the sequences be essentially completely homologous. Conditions of intermediate stringency (such as, for example, 2X SSC at 65 C) and low stringency (such as, for example 2X SSC at 55° require correspondingly less overall complementarity between the hybridizing sequences. (1X SSC is 0.15 M NaCl, 0.015 M Na citrate).
The terms peptides, proteins, and polypeptides are used interchangeably herein.
As used herein, the term "surface protein" refers to all surface accessible proteins, 0 e.g. inner and outer membrane proteins, proteins adhering to the cell wall, and secreted proteins.
A polypeptide has H. pylori biological activity if it has one, two and preferably more of the following properties: if when expressed in the course of an H. pylori infection, it can promote, or mediate the attachment ofH. pylori to a cell; it has an enzymatic activity, structural or regulatory function characteristic of an H. pylori protein; or the gene which encodes it can rescue a lethal mutation in an H. pylori gene. A polypeptide has biological activity if it is an antagonist, agonist, or super-agonist of a polypeptide having one of the above-listed properties.
A biologically active fragment or analog is one having an in vivo or in vitro activity which is characteristic of the H. pylori polypeptides of the invention contained in the Sequence Listing, or of other naturally occurring H. pylori polypeptides, one or more of the biological activities described herein. Especially preferred are fragments which exist in vivo, fragments which arise from post transcriptional processing or which arise from translation of alternatively spliced RNA's. Fragments include those expressed in native or endogenous cells as well as those made in expression systems, in CHO cells. Because peptides such as H. pylori polypeptides often exhibit a range of physiological properties and because such properties may be attributable to different portions of the molecule, a useful H. pylori fragment or H. pylori analog is one which exhibits a biological activity in any biological assay for H. pylori activity. Most preferably the fragment or analog possesses 10%, preferably 40%, more preferably 60%, 70%, 80% or 90% or greater of the activity ofH. pylori, in any in vivo or in vitro assay.
-49- Analogs can differ from naturally occurring H. pylori polypeptides in amino acid sequence or in ways that do not involve sequence, or both. Non-sequence modifications include changes in acetylation, methylation, phosphorylation, carboxylation, or glycosylation. Preferred analogs include H. pylori polypeptides (or biologically active fragments thereof) whose sequences differ from the wild-type sequence by one or more conservative amino acid substitutions or by one or more non-conservative amino acid substitutions, deletions, or insertions which do not substantially diminish the biological activity of the H. pylori polypeptide. Conservative substitutions typically include the substitution of one amino acid for another with similar characteristics, substitutions within the following groups: valine, glycine; glycine, alanine; valine, isoleucine, leucine; aspartic acid, glutamic acid; asparagine, glutamine; serine, threonine; lysine, arginine: and phenylalanine, tyrosine. Other conservative substitutions can be made in view of the table below.
*5 TABLE 2 CONSERVATIVE AMINO ACID REPLACEMENTS For Amino Acid Code Replace with any of Alanine A D-Ala, Gly, beta-Ala, L-Cys, D-Cys Arginine R D-Arg, Lys, D-Lys, homo-Arg, D-homo-Arg, Met, Ile, D-Met, D-Ile, Orn. D-Orn Asparagine N D-Asn, Asp, D-Asp, Glu, D-Glu, Gln, D-Gln Aspartic Acid D D-Asp, D-Asn, Asn, Glu, D-Glu, Gin, D-Gln Cysteine C D-Cys, S-Me-Cys, Met, D-Met, Thr, D-Thr Glutamine Q D-Gln, Asn, D-Asn. Glu, D-Glu, Asp, D-Asp Glutamic Acid E D-Glu, D-Asp, Asp, Asn, D-Asn, Gln, D-Gln Glycine G Ala, D-Ala, Pro, D-Pro, P-Ala, Acp Isoleucine I D-Ile, Val, D-Val, Leu, D-Leu, Met, D-Met Leucine L D-Leu, Val, D-Val, Leu, D-Leu, Met, D-Met Lysine K D-Lys, Arg, D-Arg, homo-Arg, D-homo-Arg, Met, D- Met, Ile, D-Ile, Orn. D-Orn Methionine M D-Met, S-Me-Cys, Ile, D-Ile, Leu, D-Leu, Val, D-Val Phenylalanine F D-Phe, Tyr, D-Thr, L-Dopa, His, D-His, Trp, D-Trp, Trans-3,4, or 5-phenylproline, cis-3,4, or Proline P D-Pro, L-I-thioazolidine-4-carboxylic acid, D-or L-1oxazolidine-4-carboxvlic acid Serine S D-Ser, Thr, D-Thr, allo-Thr, Met, D-Met, Met(O), D-Met(O). L-Cys. D-Cys Threonine T D-Thr, Ser, D-Ser, allo-Thr, Met, D-Met, Met(O), D-Met(O), Val. D-Val Tyrosine Y D-Tyr, Phe, D-Phe, L-Dopa, His, D-His Valine V D-Val, Leu, D-Leu, lie, D-Ile, Met, D-Met Other analogs within the invention are those with modifications which increase peptide stability; such analogs may contain, for example, one or more non-peptide bonds (which replace the peptide bonds) in the peptide sequence. Also included are: analogs that include residues other than naturally occurring L-amino acids, D-amino acids or nonnaturally occurring or synthetic amino acids, P or y amino acids; and cyclic analogs.
As used herein, the term "fragment", as applied to an H. pylori analog, will ordinarily be at least about 20 residues, more typically at least about 40 residues, preferably at least about 60 residues in length. Fragments of H. pylori polypeptides can be generated by methods known to those skilled in the art. The ability of a candidate fragment to exhibit a biological activity of H. pylori polypeptide can be assessed by methods known to those skilled in the art as described herein. Also included are H. pylori polypeptides containing residues that are not required for biological activity of the peptide or that result from alternative mRNA splicing or alternative protein processing events.
15 An "immunogenic component" as used herein is a moiety, such as an H. pylori polypeptide, analog or fragment thereof, that is capable of eliciting a humoral and/or cellular immune response in a host animal.
An "antigenic component" as used herein is a moiety, such as an H. pylori polypeptide, analog or fragment thereof, that is capable of binding to a specific antibody with sufficiently high affinity to form a detectable antigen-antibody complex.
As used herein, the term "transgene" means a nucleic acid (encoding, one or more polypeptides), which is partly or entirely heterologous, foreign, to the transgenic animal or cell into which it is introduced, or, is homologous to an endogenous gene of the transgenic animal or cell into which it is introduced, but which is designed to be inserted, or is inserted, into the cell's genome in such a way as to alter the genome of the cell into which it is inserted it is inserted at a location which differs from that of the natural gene or its insertion results in a knockout). A transgene can include one or more transcriptional regulatory sequences and any other nucleic acid, such as introns, that may be necessary for optimal expression of the selected nucleic acid, all operably linked to the selected nucleic acid, and may include an enhancer sequence.
As used herein, the term "transgenic cell" refers to a cell containing a transgene.
As used herein, a "transgenic animal" is any animal in which one or more, and preferably essentially all, of the cells of the animal includes a transgene. The transgene can be introduced into the cell, directly or indirectly by introduction into a precursor of the cell, by way of deliberate genetic manipulation, such as by a process of transformation of competent cells or by microinjection or by infection with a recombinant virus. This molecule may be integrated within a chromosome, or it may be extrachromosomally replicating DNA.
The term "antibody" as used herein is intended to include fragments thereof which are specifically reactive with H. pylori polypeptides.
As used herein, the term "cell-specific promoter" means a DNA sequence that serves as a promoter, regulates expression of a selected DNA sequence operably linked to the promoter, and which effects expression of the selected DNA sequence in specific cells of a tissue. The term also covers so-called "leaky" promoters, which S 15 regulate expression of a selected DNA primarily in one tissue, but cause expression in other tissues as well.
Misexpression, as used herein, refers to a non-wild type pattern of gene expression.
It includes: expression at non-wild type levels, over or under expression; a pattern of Sexpression that differs from wild type in terms of the time or stage at which the gene is expressed, increased or decreased expression (as compared with wild type) at a predetermined developmental period or stage; a pattern of expression that differs from wild type in terms of decreased expression (as compared with wild type) in a predetermined cell type or tissue type; a pattern of expression that differs from wild type in terms of the splicing size, amino acid sequence, post-transitional modification, or biological activity of 25 the expressed polypeptide; a pattern of expression that differs from wild type in terms of the effect of an environmental stimulus or extracellular stimulus on expression of the gene, a pattemrn of increased or decreased expression (as compared with wild type) in the presence of an increase or decrease in the strength of the stimulus.
As used herein, "host cells" and other such terms denoting microorganisms or higher eukaryotic cell lines cultured as unicellular entities refers to cells which can become or have been used as recipients for a recombinant vector or other transfer DNA, and include the progeny of the original cell which has been transfected. It is understood by individuals skilled in the art that the progeny of a single parental cell may not necessarily be completely identical in genomic or total DNA compliment to the original parent, due to accident or deliberate mutation.
As used herein, the term "control sequence" refers to a nucleic acid having a base sequence which is recognized by the host organism to effect the expression of encoded sequences to which they are ligated. The nature of such control sequences differs depending upon the host organism; in prokaryotes, such control sequences generally include a promoter, ribosomal binding site, terminators, and in some cases operators; in eukarvotes.
generally such control sequences include promoters, terminators and in some instances, enhancers. The term control sequence is intended to include at a minimum, all components whose presence is necessary for expression, and may also include additional components whose presence is advantageous, for example, leader sequences.
As used herein, the term "operably linked" refers to sequences joined or ligated to function in their intended manner. For example, a control sequence is operably linked to coding sequence by ligation in such a way that expression of the coding sequence is achieved under conditions compatible with the control sequence and host cell.
The metabolism of a substance, as used herein, means any aspect of the, expression, function, action, or regulation of the substance. The metabolism of a substance includes modifications, covalent or non-covalent modifications of the substance. The metabolism of a substance includes modifications, covalent or non-covalent modification, the substance induces in other substances. The metabolism of a substance 15 also includes changes in the distribution of the substance. The metabolism of a substance includes changes the substance induces in the distribution of other substances.
A "sample" as used herein refers to a biological sample, such as, for example, tissue or fluid isloated from an individual (including without limitation plasma, serum, cerebrospinal fluid, lymph, tears, saliva and tissue sections) or from in vitro cell culture 0" 0 20 constituents, as well as samples from the environment.
The practice of the invention will employ, unless otherwise indicated, conventional techniques of chemistry, molecular biology, microbiology, recombinant DNA, and immunology, which are within the skill of the art. Such techniques are explained fully in the literature. See Sambrook, Fritsch, and Maniatis, Molecular Cloning; Laboratory Manual 2nd ed. (1989); DNA Cloning, Volumes I and II (D.N Glover ed. 1985); Oligonucleotide Synthesis Gait ed, 1984); Nucleic Acid Hybridization Hames S.J. Higgins eds. 1984); the series, Methods in Enzymoloqy (Academic Press, Inc.), particularly Vol. 154 and Vol. 155 (Wu and Grossman, eds.) and PCR-A Practical Approach (McPherson, Quirke, and Taylor, eds., 1991).
I. Isolation of Nucleic Acids of H. pvlori and Uses Therefor H. pvlori Genomic Sequence This invention provides nucleotide sequences of the genome of H. pylori which thus comprises a DNA sequence library of H. pylori genomic DNA. The detailed description that follows provides nucleotide sequences of H. pylori, and also describes how the sequences were obtained and how ORFs and protein-coding sequences were identified.
Also described are methods of using the disclosed H. pylori sequences in methods including diagnostic and therapeutic applications. Furthermore, the library can be used as a -53database for identification and comparison of medically important sequences in this and other strains of H. pylori.
To determine the genomic sequence of H pylori, DNA was isolated from a strain of H. pylori (ATCC 55679) and mechanically sheared by nebulization to a median size of 2 kb. Following size fractionation by gel electrophoresis, the fragments were blunt-ended, ligated to adapter oligonucleotides, and cloned into each of 20 different pMPX vectors (Rice et al., abstracts of Meeting of Genome Mapping and Sequencing, Cold Spring Harbor, NY, 5/11-5/15, 1994, p. 225) to construct a series of "shotgun" subclone libraries.
DNA sequencing was achieved using multiplex sequencing procedures essentially as disclosed in Church et al., 1988, Science 240:185; U.S. Patents No. 4,942,124 and 5,149,625). DNA was extracted from pooled cultures and subjected to chemical or enzymatic sequencing. Sequencing reactions were resolved by electrophoresis, and the products were transferred and covalently bound to nylon membranes. Finally, the membranes were sequentially hybridized with a series of labelled oligonucleotides 15 complimentary to "tag" sequences present in the different shotgun cloning vectors. In this manner, a large number of sequences could be obtained from a single set of sequencing S: reactions. The cloning and sequencing procedures are described in more detail in the Exemplification.
Individual sequence reads obtained in this manner were assembled using the FALCONTM program (Church et al., 1994, Automated DNA Sequencing and Analysis, J.C.
Venter, ed., Academic Press) and PHRAP Green, Abstracts of DOE Human Genome Program Contractor-Grantee Workshop V, Jan. 1996, p.157). The average contig length was about 3-4 kb.
A variety of approaches are used to order the contigs so as to obtain a continuous sequence representing the entire H. pylori genome. Synthetic oligonucleotides are designed that are complementary to sequences at the end of each contig. These oligonucleotides may be hybridized to libaries ofH. pylori genomic DNA in, for example, lambda phage vectors or plasmid vectors to identify clones that contain sequences corresponding to the junctional regions between individual contigs. Such clones are then used to isolate template DNA and the same oligonucleotides are used as primers in polymerase chain reaction (PCR) to amplify junctional fragments, the nucleotide sequence of which is then determined.
The H. pylori sequences were analyzed for the presence of open reading frames (ORFs) comprising at least 180 nucleotides. As a result of the analysis of ORFs based on stop-to-stop codon reads, it should be understood that these ORFs may not correspond to the ORF of a naturally-occurring H. pylori polypeptide. These ORFs may contain start codons which indicate the initiation of protein synthesis of a naturally-occurring
H.
pyloripolypeptide. Such start codons within the ORFs provided herein can be identified by those of ordinary skill in the relevant art, and the resulting ORF and the encoded H. pylori polypeptide is within the scope of this invention. For example, within the ORFs a codon SUBSTITUTE SHEET (RULE 26) such as AUG or GUG (encoding methionine or valine) which is part of the initiation signal for protein synthesis can be identified and the ORF modified to correspond to a naturallyoccurring H. pylori polypeptide. The predicted coding regions were defined by evaluating the coding potential of such sequences with the program GENEMARKTM (Borodovsky and Mclninch. 1993, Comp. Chem. 17:123).
Other H. ovlori Nucleic Acids The nucleic acids of this invention may be obtained directly from the DNA of the above referenced H. pylori strain by using the polymerase chain reaction (PCR). See "PCR.
A Practical Approach" (McPherson, Quirke. and Taylor. eds., IRL Press. Oxford, UK, 1991) for details about the PCR. High fidelity PCR can be used to ensure a faithful DNA copy prior to expression. In addition, the authenticity of amplified products can be checked by conventional sequencing methods. Clones carrying the desired sequences described in this invention may also be obtained by screening the libraries by means of the PCR or by hybridization of synthetic oligonucleotide probes to filter lifts of the library colonies or plaques as known in the art (see, Sambrook et al., Molecular Cloning, A Laboratory Manual 2nd edition. 1989, Cold Spring Harbor Press. NY).
It is also possible to obtain nucleic acids encoding H. pylori polypeptides from a cDNA library in accordance with protocols herein described. A cDNA encoding an H.
20 pylori polypeptide can be obtained by isolating total mRNA from an appropriate strain.
Double stranded cDNAs can then be prepared from the total mRNA. Subsequently, the cDNAs can be inserted into a suitable plasmid or viral bacteriophage) vector using any one of a number of known techniques. Genes encoding H. pylori polypeptides can also be cloned using established polymerase chain reaction techniques in accordance with the 25 nucleotide sequence information provided by the invention. The nucleic acids of the invention can be DNA or RNA. Preferred nucleic acids of the invention are contained in the Sequence Listing.
The nucleic acids of the invention can also be chemically synthesized using standard techniques. Various methods of chemically synthesizing polydeoxynucleotides are known, including solid-phase synthesis which, like peptide synthesis, has been fully automated in commercially available DNA synthesizers (See Itakura et al. U.S. Patent No. 4.598.049: Caruthers et al. U.S. Patent No. 4.458.066: and Itakura U.S. Patent Nos.
4,401.796 and 4.373,071, incorporated by reference herein).
Nucleic acids isolated or synthesized in accordance with features of the present invention are useful, by way of example, without limitation, as probes, primers, capture ligands. antisense genes and for developing expression systems for the synthesis of proteins and peptides corresponding to such sequences. As probes, primers, capture ligands and antisense agents, the nucleic acid normally consists of all or part (approximately twenty or more nucleotides for specificity as well as the ability to form stable hybridization products)
I
of the nucleic acids of the invention contained in the Sequence Listing. These uses are described in further detail below.
Probes A nucleic acid isolated or synthesized in accordance with the sequence of the invention contained in the Sequence Listing can be used as a probe to specifically detect H.
pylori. With the sequence information set forth in the present application, sequences of twenty or more nucleotides are identified which provide the desired inclusivity and exclusivity with respect to H. pylori, and extraneous nucleic acids likely to be encountered during hybridization conditions. More preferably, the sequence will comprise at least twenty to thirty nucleotides to convey stability to the hybridization product formed between the probe and the intended target molecules.
Sequences larger than 1000 nucleotides in length are difficult to synthesize but can be generated by recombinant DNA techniques. Individuals skilled in the art will readily recognize that the nucleic acids, for use as probes, can be provided with a label to facilitate detection of a hybridization product.
•-Nucleic acid isolated and synthesized in accordance with the sequence of the invention contained in the Sequence Listing can also be useful as probes to detect homologous regions (especially homologous genes) of other Helicobacter species using 20 appropriate stringency hybridization conditions as described herein.
Capture Ligand For use as a capture ligand, the nucleic acid selected in the manner described above with respect to probes, can be readily associated with a support. The manner in which nucleic acid is associated with supports is well known. Nucleic acid having twenty or more nucleotides in a sequence of the invention contained in the Sequence Listing have utility to i •...separate H. pylori nucleic acid from the nucleic acid of each other and other organisms.
S* i"Nucleic acid having twenty or more nucleotides in a sequence of the invention contained in the Sequence Listing can also have utility to separate other Helicobacter species from each :other and from other organisms. Preferably, the sequence will comprise at least twenty nucleotides to convey stability to the hybridization product formed between the probe and the intended target molecules. Sequences larger than 1000 nucleotides in length are difficult to synthesize but can be generated by recombinant DNA techniques.
Primers Nucleic acid isolated or synthesized in accordance with the sequences described herein have utility as primers for the amplification ofH. pylori nucleic acid. These nucleic acids may also have utility as primers for the amplification of nucleic acids in other Helicobacter species. With respect to polymerase chain reaction (PCR) techniques, nucleic acid sequences of 10-15 nucleotides of the invention contained in the Sequence Listing have utility in conjunction with suitable enzymes and reagents to create copies of H. pylori -56nucleic acid. More preferably, the sequence will comprise twenty or more nucleotides to convey stability to the hybridization product formed between the primer and the intended target molecules. Binding conditions of primers greater than 100 nucleotides are more difficult to control to obtain specificity. High fidelity PCR can be used to ensure a faithful DNA copy prior to expression. In addition, amplified products can be checked by conventional sequencing methods.
The copies can be used in diagnostic assays to detect specific sequences, including genes from H. pylori and/or other Helicobacter species. The copies can also be incorporated into cloning and expression vectors to generate polypeptides corresponding to the nucleic acid synthesized by PCR, as is described in greater detail herein.
Antisense Nucleic acid or nucleic acid-hybridizing derivatives isolated or synthesized in accordance with the sequences described herein have utility as antisense agents to prevent the expression of H. pylori genes. These sequences also have utility as antisense agents to prevent expression of genes of other Helicobacter species.
~In one embodiment, nucleic acid or derivatives corresponding to H. pylori nucleic acids is loaded into a suitable carrier such as a liposome or bacteriophage for introduction S.into bacterial cells. For example, a nucleic acid having twenty or more nucleotides is capable of binding to bacteria nucleic acid or bacteria messenger RNA. Preferably, the 20 antisense nucleic acid is comprised of 20 or more nucleotides to provide necessary stability of a hybridization product of non-naturally occurring nucleic acid and bacterial nucleic acid and/or bacterial messenger RNA. Nucleic acid having a sequence greater than 1000 •nucleotides in length is difficult to synthesize but can be generated by recombinant DNA techniques. Methods for loading antisense nucleic acid in liposomes is known in the art as exemplified by U.S. Patent 4.241,046 issued December 23, 1980 to Papahadjopoulos et al.
9 II. Expression of H. pylori Nucleic Acids Nucleic acid isolated or synthesized in accordance with the sequences described herein have utility to generate polypeptides. The nucleic acid of the invention exemplified in the Sequence Listing or fragments of said nucleic acid encoding active portions of H.
pylori polypeptides can be cloned into suitable vectors or used to isolate nucleic acid. The isolated nucleic acid is combined with suitable DNA linkers and cloned into a suitable vector.
The function of a specific gene or operon can be ascertained by expression in a bacterial strain under conditions where the activity of the gene product(s) specified by the gene or operon in question can be specifically measured. Alternatively, a gene product may be produced in large quantities in an expressing strain for use as an antigen, an industrial reagent, for structural studies. etc. This expression can be accomplished in a mutant strain which lacks the activity of the gene to be tested, or in a strain that does not produce the same gene product(s). This includes, but is not limited to other Helicobacter strains, or other bacterial strains such as E. coli, Norcardia. Corynebacterium, Campylobacter, and Streptomyces species. In some cases the expression host will utilize the natural Helicobacter promoter whereas in others, it will be necessary to drive the gene with a promoter sequence derived from the expressing organism an E. coli betagalactosidase promoter for expression in E. coli).
To express a gene product using the natural H. pylori promoter, a procedure such as the following can be used. A restriction fragment containing the gene of interest, together with its associated natural promoter element and regulatory sequences (identified using the DNA sequence data) is cloned into an appropriate recombinant plasmid containing an origin of replication that functions in the host organism and an appropriate selectable marker. This can be accomplished by a number of procedures known to those skilled in the art. It is most preferably done by cutting the plasmid and the fragment to be cloned with the same restriction enzyme to produce compatible ends that can be ligated to join the two pieces together. The recombinant plasmid is introduced into the host organism by, for example, electroporation and cells containing the recombinant plasmid are identified by .'.selection for the marker on the plasmid. Expression of the desired gene product is detected using an assay specific for that gene product.
In the case ofa gene that requires a different promoter, the body of the gene (coding 20 sequence) is specifically excised and cloned into an appropriate expression plasmid. This subcloning can be done by several methods, but is most easily accomplished by PCR amplification of a specific fragment and ligation into an expression plasmid after treating the PCR product with a restriction enzyme or exonuclease to create suitable ends for cloning.
A suitable host cell for expression of a gene can be any procaryotic or eucaryotic cell. For example, an H. pylori polypeptide can be expressed in bacterial cells such as E.
coli, insect cells (baculovirus), yeast, or mammalian cells such as Chinese hamster ovary cell (CHO). Other suitable host cells are known to those skilled in the art.
Expression in eucaryotic cells such as mammalian, yeast, or insect cells can lead to partial or complete glycosylation and/or formation of relevant inter- or intra-chain disulfide bonds of a recombinant peptide product. Examples of vectors for expression in yeast S. cerivisae include pYepSecl (Baldari. et al., (1987) Embo J. 6:229-234), pMFa (Kurjan and Herskowitz, (1982) Cell 30:933-943), pJRY88 (Schultz et al., (1987) Gene 54:113- 123), and pYES2 (Invitrogen Corporation, San Diego, CA). Baculovirus vectors available for expression of proteins in cultured insect cells (SF 9 cells) include the pAc series (Smith et al., (1983) Mol. Cell Biol. 3:2156-2165) and the pVL series (Lucklow, and Summers, (1989) Virology 170:31-39). Generally, COS cells (Gluzman. (1981) Cell 23:175-182) are used in conjunction with such vectors as pCDM 8 (Aruffo, A. and Seed, (1987) Proc. Natl. Acad. Sci. USA 84:8573-8577) for transient -58amplification/expression in mammalian cells, while CHO (dhfr- Chinese Hamster Ovary) cells are used with vectors such as pMT2PC (Kaufman et al. (1987), EMBO J. 6:187-195) for stable amplification/expression in mammalian cells. Vector DNA can be introduced into mammalian cells via conventional techniques such as calcium phosphate or calcium chloride co-precipitation, DEAE-dextran-mediated transfection, or electroporation.
Suitable methods for transforming host cells can be found in Sambrook et al. (Molecular Clonine: A Laboratory Manual. 2nd Edition, Cold Spring Harbor Laboratory press (1989)), and other laboratory textbooks.
Expression in procaryotes is most often carried out in E. coli with either fusion or non-fusion inducible expression vectors. Fusion vectors usually add a number ofNH 2 terminal amino acids to the expressed target gene. These NH 2 terminal amino acids often are referred to as a reporter group. Such reporter groups usually serve two purposes: 1) to increase the solubility of the target recombinant protein; and 2) to aid in the purification of the target recombinant protein by acting as a ligand in affinity purification. Often, in fusion expression vectors, a proteolytic cleavage site is introduced at the junction of the reporter group and the target recombinant protein to enable separation of the target recombinant protein from the reporter group subsequent to purification of the fusion protein. Such enzymes, and their cognate recognition sequences, include Factor Xa, thrombin and enterokinase. Typical fusion expression vectors include pGEX (Amrad Corp., Melboure, 20 Australia), pMAL (New England Biolabs, Beverly, MA) and pRIT5 (Pharmacia, Piscataway, NJ) which fuse glutathione S-transferase, maltose E binding protein, or protein A, respectively, to the target recombinant protein. A preferred reporter group is poly(His), which may be fused to the amino or carboxy terminus of the protein and which renders the recombinant fusion protein easily purifiable by inetal chelate chromatography.
Inducible non-fusion expression vectors include pTrc (Amann et al., (1988) Gene 69:301-315) and pETl Id (Studier et al., Gene Expression Technology: Methods in Enzvmologv 185, Academic Press, San Diego, California (1990) 60-89). While target gene expression relies on host RNA polymerase transcription from the hybrid trp-lac fusion promoter in pTrc, expression of target genes inserted into pET1 Id relies on transcription from the T7 gnl 0-lac 0 fusion promoter mediated by coexpressed viral RNA polymerase (T7 gnl). This viral polymerase is supplied by host strains BL21(DE3) or HMS174(DE3) from a resident X prophage harboring a T7 gnl under the transcriptional control of the lacUV 5 promoter.
For example, a host cell transfected with a nucleic acid vector directing expression of a nucleotide sequence encoding an H. pylori polypeptide can be cultured under appropriate conditions to allow expression of the polypeptide to occur. The polypeptide may be secreted and isolated from a mixture of cells and medium containing the peptide.
Alternatively, the polypeptide may be retained cytoplasmically and the cells harvested, lysed and the protein isolated. A cell culture includes host cells, media and other -59byproducts. Suitable media for cell culture are well known in the art. Polypeptides of the invention can be isolated from cell culture medium, host cells, or both using techniques known in the art for purifying proteins including ion-exchange chromatography, gel filtration chromatography, ultrafiltration, electrophoresis, and immunoaffinity purification with antibodies specific for such polypeptides. Additionally, in many situations, polypeptides can be produced by chemical cleavage of a native protein tryptic digestion) and the cleavage products can then be purified by standard techniques.
In the case of membrane bound proteins, these can be isolated from a host cell by contacting a membrane-associated protein fraction with a detergent forming a solubilized complex, where the membrane-associated protein is no longer entirely embedded in the membrane fraction and is solubilized at least to an extent which allows it to be chromatographically isolated from the membrane fraction. Several different criteria are used for choosing a detergent suitable for solubilizing these complexes. For example, one property considered is the ability of the detergent to solubilize the H. pylori protein within the membrane fraction at minimal denaturation of the membrane-associated protein allowing for the activity or functionality of the membrane-associated protein to return upon reconstitution of the protein. Another property considered when selecting the detergent is the critical micelle concentration (CMC) of the detergent in that the detergent of choice preferably has a high CMC value allowing for ease of removal after reconstitution. A third 20 property considered when selecting a detergent is the hydrophobicity of the detergent.
Typically, membrane-associated proteins are very hydrophobic and therefore detergents which are also hydrophobic, the triton series, would be useful for solubilizing the hydrophobic proteins. Another property important to a detergent can be the capability of the detergent to remove the H. pylori protein with minimal protein-protein interaction facilitating further purification. A fifth property of the detergent which should be considered is the charge of the detergent. For example, if it is desired to use ion exchange S resins in the purification process then preferably detergent should be an uncharged detergent. Chromatographic techniques which can be used in the final purification step are known in the art and include hydrophobic interaction, lectin affinity, ion exchange, dye affinity and immunoaffinity.
One strategy to maximize recombinant H. pylori peptide expression in E. coli is to express the protein in a host bacteria with an impaired capacity to proteolytically cleave the recombinant protein (Gottesman. Gene Expression Technology: Methods in Enzvmologyv 185, Academic Press, San Diego, California (1990) 119-128). Another strategy would be to alter the nucleic acid encoding an H. pylori peptide to be inserted into an expression vector so that the individual codons for each amino acid would be those preferentially utilized in highly expressed E. coli proteins (Wada et al., (1992) Nuc. Acids Res. 20:2111-2118). Such alteration of nucleic acids of the invention can be carried out by standard DNA synthesis techniques.
I
The nucleic acids of the invention can also be chemically synthesized using standard techniques. Various methods of chemically synthesizing polydeoxynucleotides are known, including solid-phase synthesis which, like peptide synthesis, has been fully automated in commercially available DNA synthesizers (See, Itakura et al. U.S. Patent No. 4,598,049; Caruthers et al. U.S. Patent No. 4,458,066; and Itakura U.S. Patent Nos.
4,401,796 and 4,373,071, incorporated by reference herein).
III. H. pylori Polvpeptides This invention encompasses isolated H. pylori polypeptides encoded by the disclosed H. pylori genomic sequences, including the polypeptides of the invention contained in the Sequence Listing. Polypeptides of the invention are preferably at least amino acid residues in length. Using the DNA sequence information provided herein, the amino acid sequences of the polypeptides encompassed by the invention can be deduced using methods well-known in the art. It will be understood that the sequence of an entire nucleic acid encoding an H. pylori polypeptide can be isolated and identified based on an ORF that encodes only a fragment of the cognate protein-coding region. This can be acheived, for example, by using the isolated nucleic acid encoding the ORF. or fragments thereof, to prime a polymerase chain reaction with genomic H. pylori DNA as template; this is followed by sequencing the amplified product.
20 The polypeptides of the invention can be isolated from wild-type or mutant H.
pylori cells or from heterologous organisms or cells (including, but not limited to. bacteria, yeast. insect, plant and mammalian cells) into which an H. pylori nucleic acid has been introduced and expressed. In addition, the polypeptides can be part of recombinant fusion proteins.
25 H. pylori polypeptides of the invention can be chemically synthesized using commercially automated procedures such as those referenced herein.
Many of the polypeptides of the invention are related to one another. Some of these relationships are described in Table 3 below. Most polypeptides described in Table 3 are over 90% identical to one another as noted in the last two columns; some are between and 90% identical to one another; and very few share between 60% and 70% identity with each other. The polypeptides represented by the sequence identification numbers in the third column of Table 3 result from translations carried out from stop codon to stop codon in the genomic nucleotide sequence of the invention, while those in the first column result from translations carried out from the first methionine or valine codon following the prior stop codon and proceeding to the final stop codon in the nucleotide sequence. In some cases, the nucleotide sequence encoding the related polypeptides is slightly different, resulting in some differences in amino acid residues of the related polypeptides. In many cases, the related polypeptides differ significantly in length, with one polypeptide containing amino acid residues in addition to those in common between the two
I
polypeptides. In all cases, the relationships described in Table 3 are highly significant, and the nucleotide sequences encoding these related polypeptides are also very similar to one another. For example, the nucleotide probes derived from the coding sequence of the polypeptides in column one can be used in PCR or hybridization experiments to identify clones carrying the nucleotide sequence encoding the polypeptides of column three.
The relationships between the polypeptides shown in Table 3 can be classified in five broad categories as follows. First, for many polypeptides (designated in the last column of the Table the polypeptide denoted in column one is identical to the polypeptide denoted in column three except for an occasional addition of a few putative amino acid residues at the N-terminus which result from the fact that the polypeptides of column three were derived by translating from stop codon to stop codon instead of from a predicted start codon Met or Val) to a stop codon as was done for the polypeptides in column one.
Second. for most polypeptides (designated in the last column of the Table 3), the polypeptide of column one is at least 95% identical to the polypeptide of column three except that the polypeptide in column three is longer (at either or both ends) by one or more amino acid residues which do not result from the difference between reading from stop to stop instead of from start to stop.
Third, for some polypeptides (designated in the last column of Table the 20 converse is true, the polypeptide of column one is at least 95% identical to the polypeptide of column three except that the polypeptide in column three is shorter (at either or both ends).
Fourth, for some polypeptides (designated in the last column of Table the t polypeptide of column one shares a high level of amino acid identity at least with the polypeptide of column three in the region in which they overlap, but shares little or no identity less than 95%) at one or both ends. The level of identity of the polypeptides in columns one and three in categories and is highly significant.
For example, a typical H. pylori gene product will exhibit amino acid sequence identities of between 92% to 100% among strains ofH. pylori isolated from human patients (see Table 10 below).
Finally, a fifth class of polypeptides in column one (designated in the last column of Table 3) are closely related but differ significantly less than 95% identical) from the polypeptide of column three. These polypeptides are likely "paralogs," members of related gene families in H. pylori.
TABLE3 Length Length Identity: SeqID (aa) SeqID (aa) Overlap Length Category 384 509 1779 593 100.0 504aa
B
386 133 1713 205 99 2 127 aa B 387 158 1743 340 9 8.7"155aa
B
388 112 1489 330 100.0 105aa
B
389 650 1643 369 95.4"65aa
D
390 62 1598 327 90.2-61aa
E
391 619 1747 991 99.3 :608aa
B
392 110 1570 183 93.1 :101 aa E 393 68 1811 85 97.1 68aa
B
394 446 1884 594 99.5:433 aa B 395 84 1503 347 100.0-84aa
B
396 40 1504 519 88.2 34aa
E
397 300 1531 273 9 8.9"267aa
C
398 214 1795 197 99.0 192aa
C
399 137 1639 199 96.4"137aa
B
400 272 1725 285 99.3 271 aa
B
401 287 1470 455 98.9"277aa
D
402 106 1596 302 99.1 106 aa B 403 157 1654 197 99.3 150 aa B 404 278 1552 362 100.0"277aa
B
405 120 1858 529 100.0-116aa
B
406 226 1562 297 100.0"216aa
B
407 62 1752 157 77.6 "58aa
E
408 50 1663 74 97.9 47aa
B
410 188 1803 351 87.1 155 aa E 411 130 1685 497 100.0 129aa
B
412 183 1843 185 "100.0"183 aa A 413 194 1874 508 97.6: 169aa
D
414 235 1518 246 100.0 235aa
B
415 88 1538 676 97.5:80aa
B
416 109 1871 335 99.1 109 aa B 417 107 1782 593 94.4 :90 aa E 418 136 1544 441 100.0:135aa
B
419 54 1513 175 97.0 :33aa
E
420 125 1642 539 96.7-122aa
B
421 249 1738 346 99 .6"249aa
B
422 86 1715 128 97.5:79aa
B
423 128 1534 149 100.0:128aa
B
424 93 1875 178 100.0:93aa
B
425 88 1804 105 97.7 88 aa B 426 128 1524 116 62.4:117aa
E
427 108 1762 109 100.0 :108aa
A
428 118 1539 276 100.0 :ll8aa
B
429 54 1754 113 89.6:48aa
E
430 288 1483 377 95.5:286aa
B
431 303 1785 248 98.2:170aa
D
431 303 1784 148 96.
4 :138aa
D
432 192 1478 408 99.5 :192aa
B
433 168 1517 426 99.3 151 aa D C C
C
C.
C C
C
C
C
C C. C
C.
C.
C C CC. C 434 153 1679 403 100.0:153 aa B 435 162 1806 173 98.1 :161 aa B 436 59 1834 80 37.5 :24 aa E 437 222 1533 288 100.0 :221 aa B 438 53 1737 260 93.5 3l1aa E 439 109 1683 121 100.0:109 aa B 440 73 1773 280 100.0 73 aa B 441 237 1685 497 96:'0: 198 aa D 442 92 1521 646 100.0 84 aa D 443 97 1774 327 100.0 96 aa B 444 280 1556 284 100.0 280 aa A 445 187 1604 253 95.5 :155 aa D 446 58 1510 198 96.4 :55aa B 447 85 1496 155 100.0 85 aa B 448 90 1724 90 100.0 90Oaa A 449 105 1788 141 98.0: 100aa D 450 172 1495 239 100.0 172 aa B 451 212 1456 139 81.7: 126 aa E 452 182 1702 192 97.0 166 aa D 453 224 1658 228 100.0 224 aa A 454 131 1895 159 100.0:131 aa B 455 73 1787 370 100.0 54 aa D 456 92 1587 295 96.6 87 aa B 457 205 1735 310 100.0:195 aa B 458 41 1479 144 97.6 41laa B 459 219 1584 297 100.0 219 aa B 460 188 1546 375 89.3: 187 aa E 461 231 1780 438 97.3 225 aa B 462 63 1645 71 100.0 :63 aa B 463 183 1664 242 97.8 182 aa B 464 117 1586 234 99.1 113 aa B 465 153 1773 280 98.0:153 aa B 466 43 1610 308 100.0 :43 aa B 467 240 1636 255 97.0 237 aa B 468 209 1868 240 96.6 :206 aa B 469 95 1628 321 98.5 65 aa D 470 229 1595 375 96.5 :228 aa B 471 92 1713 205 90.1 :71 aa E 472 96 1492 352 95.4 :87 aa B 473 1178 1748 1183 100.0 1178 aa A 474 163 1822 113 92.7 :109 aa E 474 163 1820 88 93.1 :58 aa E 475 466 1840 467 100.0 :466 aa A 476 60 1500 90 97.0 :33 aa D 477 249 L854 254 100.0 :248 aa B 478 44 1772 528 100.0 :44 aa B 479 421 1693 421 99.8 :421 aa A 480 167 1555 340 98.1 :162 aa B 481 89 1888 236 100.0 :89 aa B 482 237 1873 461 97.5 23 6 aa B 483 471 1594 428 99.3 301 aa C 484 123. 1655 366 87.9:l107 aa E 485 127 1655 366 99.2 :127 aa B 486 259 1517 259 100.0 259 aa A 487 17 1481 101 93.3 15 aa E 488 77 1704 246 100.0 77 aa B -64- 489 180 1554 180 100.0 180 aa A 490 213 1638 577 92.3 209 aa E 491 148 1452 157 100.0: 148 aa B 492 281 1519 849 99.6 281 aa B 493 144 1525 377 9 4 .9:118 aaD 494 73 1539 276 95.8 :71 aa B 495 311 1670 446 9 9 .0O:311 aaB 496 i15 1842 384 9 9.1 114 aaB 497 200 1600 459 100.0 200 aaB 498 264 1828 458 100.0 :264 aaB 499 339 1490 362 9 9.7:339 aaB 500 146 1449 430 9 4.4: 142 aaE 501 60 1465 240 98.3 58 aaB 502 351 1458 532 9 8.6:346 aa B 503 233 1666 296 94.3 :230 aa E 504 32 1513 175 100.0 :32 aa B 505 171 1462 452 91.8 :171 aa B 506 33 1672 121 100.0:24 aa D 507 100 1650 192 8 0.0:90Oaa E 508 79 1772 528 8 0.8:78 aa E 509 70 1662 88 96.2 53 aa D 510 130 1530 131 100.0 130Oaa A 51 53 1723 163 91.8 49 aa E 12 79 1572 189 9 8.5 65 aa D *513 102 1889 114 99.0:100 aa B o* 514 15 1516 407 100.0:l12 aa B 515 378 1747 991 9 7 .9 3 77 aa B *516 1027 1692 2440 100.0:1027 aa B *517 155 1831 182 89.6: 154 aa E 518 62 1552 362 7 4.5 47 aa E 519 237 1557 241 100.0:237 aa A 520 83 1627 424 100.0 83 aa B *522 64 1680 227 98.4 63 aa B 523 228 1532 241 100.0 228 aa B 524 273 1710 189 97.2:180Oaa C *524 273 1712 115 100.0 :99 aa C 525 15 1612 65 100.0 :I15aa B 526 115 1733 112 9 4.6 :lIlIaa C *527 67 1755 156 100.0 :62 aa D :::528 323 1635 336 100.0 :322 aa B 529 10 1731 101 50.0 :l10aa B 530 12 1455 284 100.0:l12 aa B 531 79 1528 101 94.9 :79 aa B 532 95 1887 279 100.0 :95 aa B 533 154 1591 168 100.0 :152 aa B 534 68 1501 283 100.0 :67 aa B 535 313 1519 849 95.5 313 aa B 536 319 1486 325 100.0 :319 aa A 537 118 1707 154 90.9:110 aa E 538 89 1674 161 88.2 :76 aa E 539 92 1838 100 100.0 :92 aa A 540 138 1525 377 86.9 :137 aa B 541 277 1661 394 96.0 :273 aa D 542 254 1567 392 98.0 :254 aa B 543 185 1467 594 99.5 185 aa B 544 37 1886 326 100.0 -37.aa B 545 94 1772 528 89.1 :92 aa E 546 182 1760 366 100.0 182 aa B 547 247 1776 150 100.0:146 aa C 547 247 1775 88 100.0O:87 aa C 548 422 1798 426 100.0:422 aa A 549 61 1620 78 96.7 60 aa B 550 54 1566 309 37.8:45 aa E 551 298 1751 518 98.0 :297 aa B 552 91 1738 346 95.5 :88 aa D 553 111 1764 130 100.0:l111aa
B
554 137 1626 93 100.0 :84 aa D 555 124 1717 114 89.2:111laa
E
556 86 1597 432 89.7:78 aa E 557 87 1457 97 100.0 86 aa B 558 108 1750 154 99.1 108 aa B 559 142 1619 211 97.9 141laa B 560 231 1580 315 99.6 231 aa B 561 186 1446 275 88.3:180Oaa
E
562 183 1515 198 100.0:183 aa B 563 154 1477 188 100.0 154 aa B 564 288 1767 303 100.0:288 aa B 565 420 1841 424 100.0:420 aa A 566 72 1450 486 98.5:67 aa D 567 205 1799 270 99.5:199 aa D .*568 328 1893 338 100.0 328 aa B 569 140 1855 614 84.8 :125 aa E .~:570 76 1499 184 98.1 53 aa D 571 194 1660 201 100.0:193 aa B 572 140 1583 163 96.9: 130aa D *573 308 1676 316 .100.0:308 aa B 574 339 1667 468 99.1 335 aa B 575 207 1688 208 98.1 :207 aa A 576- 251 1891 267 100.0:251 aa B *577 69 1745 109 96.7 61Iaa D 578 112 1519 849 99.1:112 aa B 579 152 1649 543 98.7 152 aa B 580 130 1853 220 98.3: 120aa D 581 113 1614 134 100.0 :113 aa B 582 174 1569 209 1 0 0 .0O:174 aaB '9583 35 1752 157 34.4 :32 aa E 584 308 !728 316 100.0 307 aa B 585 702 1857 797 99.9 :702 aa B 586 293 1633 664 9 6 .2 :293 aa B 587 52 1542 429 100.0:52 aaB 588 182 1504 519 100.0 182 aa B 589 251 1622 262 99.6 251 aa B 590 40 1632 61 9 7 .5:40Oaa B 591 122 1691 717 99.1 11 llaa D 592 113 1768 121 100.0:113 aa B 593 437 1520 448 100.0 :437 aa A 594 146 1549 200 9 3 .2 146 aa E 595 128 1494 131 99.2:127 aa B 596 95 1667 468 100.0 :93 aaB 597 102 1447 149 100.0 .91laa D 598 127 1879 138 100.0:127 aa B 599 502 1881 928 99.2 500 aa B 600 42 1625 91 100.0 :42 aa B 601 341 1454 381 99.7 341 aa B 602 465 1694 442 98.2 433 aa D 602 465 1896 259 99.6:238 aa D 603 193 1484 229 99.4: 170aa D 604 141 1673 130 97.6: 126 aa D 605 159 1582 358 83,3: 156aa E 606 376 1565 382 100.0 :376 aa B 607 352 1862 363 99.1 :352 aa B 608 88 1807 144 98.7:77 aa D 609 86 1553 181 72.0 82 aa E 610 76 1527 77 100.0 76 aa A 611 98 1732 118 98.9:95 aa B 612 162 1525 377 91.3 :161 aa E 613 58 1547 152 98.3 58 aa B 614 66 1470 455 85.2 :61 aa E 615 117 1844 982 95.5 111laa D 616 83 1723 163 96.3:82 aa B 617 77 1763 275 89.6 77 aa E 618 176 1696 149 93.6:125 aa E 618 176 1698 231 92.3 65 aa E 619 144 1498 577 96.0:124 aaD 620 90 1516 407 98.9 90Oaa B 621 268 1571 275 100.0 268 aa B 622 171 1753 206 99.4:171 aa B 623 102 1559 256 100.0 :84 aa D 624 117 1819 640 94.2 104 aa E 625 237 1758 842 99.6 :233 aa B 9626 199 1464 200 100.0 198 aa C 627 225 1611 347 97.7 221 aa B 627 225 1608 97 97.8 91laa C 628 86 1772 528 90.4 83 aa E :629 496 1558 539 100.0 496 aa B 630 142 1778 3 32 99.1 11 llaa D 631 15 3 1709 111 76.9 108 aa E 631 153 1708 76 60.9 46 aa E 63 3 93 1848 106 100.0:93 aa B 634 177 1603 531 98.9:l175 aa B 635 88 1812 93 100.0 88 aa A 636 115 1746 122 100.0 115 aa B 637 261 1850 304 98.5 260 aa B 638 191 1691 717 99.5 185 aa B 639 351 1697 3 73 99.7 351laa B 640 351 1601 355 100.0 342 aa D 641 146 1592 320 96.6:145 aa B 642 190 1796 376 100.0 190Oaa B 643 489 1705 957 99.4 468 aa D 644 249 1706 249 100.0 248 aa A 645 120 1540 269 100.0 104 aa D 646 109 1550 350 100.0 108 aa B 648 158 1573 237 95.5 :155 aa D 649 312 1721 3 12 100.0 312 aa A 650 56 1839 242 98.1 52 aa D 651 199 1813 261 99.5 196 aa B 652 82 1756 99 96.3 81 aa D 653 89 1475 227 100.0 $9 aa B 0 *0e* 9 9* S 9.
4 9* V S
S
654 111 1535 119 98.2 111 aa B 655 65 1686 276 98.3 59 aa D 656 268 1892 272 100.0 268 aa A 657 100 1597 432 100.0:84 aa D 658 80 1640 276 97.2 72 aa D 659 205 1824 217 100.0:205 aa B 660 124 1471 67 98.4:64 aa D 660 124 1472 186 96.7:60Oaa D 661 93 1618 95 98.9 93 aa B 662 80 1568 170 98.7 79 aa B 663 214 1749 224 100.0:214 aa B 664 78 1668 214 97.3 :75 aa D 665 177 1844 982 78.6 173 aa E 666 258 1578 275 94.1 :254 aa E 667 75 1742 360 100.0 :75 aa B 668 421 1699 421 99.5 :421 aa A 669 81 1542 429 100.0 :S81aa B 670 112 1540 269 76.1 113 aa E 671 326 1689 246 92.8 208 aa E 672 272 1727 279 100.0 271 aa A 6 73 78 1661 394 100.0 78 aa B 674 400 1736 419 100.0 400 aa B 675 91 1522 273 95.5 88 aa D 676 126 1561 131 100.0: 126 aa A 677 195 1577 301 76.5 196 aa E 678 72 1814 90 98.6 72 aa B 679 111 1572 189 100.0:l111aa B 680 142 1847 207 92.6: 135aa E 681 63 1516 407 96.4 56 aa D 682 310 1700 446 99.3 301laa B 683 169 1744 219 100.0 169 aa B 684 85 1611 347 88.1 84 aa E 685 77 1829 251 97.3 75 aa D 686 197 1634 425 99.0 194 aa D 687 142 1722 197 100.0 136 aa D 688 86 1805 87 100.0 86 aa A 689 121 1759 356 97.5: 118aaB 690 59 1789 77 84.6 52 aa E 691 142 1675 420 97.1: 140aa B 692 80 1722 197 83.3:60Oaa E 693 180 1659 187 100.0 179 aa B 694 75 1529 159 100.0 :75 aa B 695 99 1849 119 100.0 :99 aa B 696 209 1701 430 99.5 :205 aa B 697 75 161~6 196 100.0:75 aa B 698 121 1678 460 100.0:121 aa B 699 102 1579 139 99.0100 aa B 700 131 1595 375 99.2:131 aa B 701 441 1488 444 96.9:426 aa D 702 127 1774 327 99.1 :116 aa D 703 287 1765 327 93.9:279 aa E 704 46 1581 111 95.2 21 aa D 705 115 1647 117 100.0 115 aa A 706 86 1463 111 100.0 86 aa B 707 44 1588 68 100.0 44 aa B 708 560 1589 1413 98.8 :560 aa B 09 .9V9
S
S.
S
709 125 1607 443 95.8 :118 aa D 710 96 1469 540 100.0 7 3 aa D 711 81 1629 244 9 6 .3 80 aa D 712 141 1671 375 100.0:125 aa D 713 51 1867 193 96.1 :51 aa B 714 233 1833 240 9 9 .5 :218 aa D 715 266 1644 271 100.0:265 aa B 716 158 1883 226 94.7 150 aa E 717 191 1860 240 100.0 189 aa B 718 243 1817 256 9 9 243 aa B 719 236 1617 667 98.3 236 aa B 720 175 1523 592 97.1 :172 aa B 721 226 1770 340 92.7 218 aa E 722 79 1629 244 100.0 74 aa D 723 65 1506 229 100.0 49 aa D 724 138 1675 426 9 3.2 132 aa E 725 210 1832 215 100.0 210 aa A 726 296 1821 223 100.0 190Oaa D 726 296 1819 640 99.1 10 lOaa D 727 94 1706 249 97.8 :91 aa D 728 83 1593 171 100.0 83 aa B 729 203 1448 268 100.0: 202 aa B 730 220 1656 242 100.0 :220 aa B :.731 116 1818 196 100.0 :l115aa B 732 248 1474 248 100.0 :248 aa A 73)3 150 1459 347 100.0 :118 aa D 734 228 1545 302 96.9: 227 aa B *735 187 1597 432 100.0 :172 aa D *736 198 1761 354 100.0 :198 aa B 737 208 1780 438 9 3.8 208 aa E *738 201 1842 384 100.0:193 aa D **739 127 1669 405 21.6:74 aa E *;740 79 1615 280 97.3 :75 aa D 741 49 1878 443 91.3 46 aa E 742 412 1877 425 97.8 412 aa B *743 89 1482 111 100.0 :89 aa B 744 192 1502 222 98.4 :189 aa B 745 109 1797 304 96.3:l109 aa B 746 116 1791 359 94.8:l116 aa B :747 163 1711 321 100.0:163 aa B 748 40 1483 377 100.0:40Oaa
B
749 45 1770 340 95.2 42 aa D 750 118 1867 193 92.2 116 aa E 751 200 1491 211 100.0 200 aa B 752 79 1890 80 100.0 79 aa A 753 98 1837 268 98.7 79 aa D 754 146 1653 413 100.0:141 aa B 755 206 1638 577 93.7 206 aa B 756 97 1526 89 100.0 66 aa D 757 197 1794 198 100.0 197 aa A 758 149 1872 94 97.5 80Oaa D 759 68 1882 291 100.0:68 aa B 760 135 1631 162 99.3 :134 aa B 761 93 1884 594 100.0 69 aa D 762 73 1883 226 100.0 73 aa B 763) 268 1859 430 9 5.
4 2 63 aa B -69- 764 274 1537 277 100.0 :273 aa B 765 134T 1714 136 99.2 :133 an A 766 72 1810 74 9 5.8 71laa A 767 147 1802 285 100.0:147 an B 768 144 1541 241 100.0 144 aa B 769 47 1684 75 100.0 47 aa B 770 129 1505 183 9 0.
2 :122 aa E 771 242 1536 235 99.1 232 an C 772 97 1851 129 99 .0:97 aa B 773 143 1826 259 96.5 :143 aa B 774 218 1777 383 9 9 .5 :217 aa B 775 84 1637 143 100.0 84 aa B 776 76 1774 3 27 95.9 :73 an 777 155 1585 263 79.7:133 an E 778 192 1480 299 9 1.5 189 aa E 779 171 1551 186 99.
4 171laa B 780 141 1760 366 99.2: 129 aa D 781 70 1741 95 100.0 :70Oaa B 782 153 1687 223 98.0:153 an 783 183 1869 184 100.0:183 an 784 67 1846 231 100.0 67 aaB 1785 254 1730 256 100.0 :253 an 786 173 1466 251 100.0 166 nn 787 259 1808 322 1 0 0 .0 238 aaD 788 294 1786 131 93.7:126 aan 788 294 1630 163 9 4 116 aan 789 194 1655 366 9 9 .2 :122 aa D 789 194 1646 75 100.0 72 aa C 790 132 1790 273 100.0 132 aa B 791 213 1575 216 98.1 213 an A *792 47 1605 86 1 0 0 .0 :47 aa B 793 143 1864 342 93.0 :143 an E 794 69 1766 93 100.0 :69 aa B *795 144 1504 519 95.7:138 an D 796 190 1590 193 100.0 190 aa A 797 84 1792 215 8 3.5 79 aa E 798 135 1613 138 100.0:135 an A 799 255 1885 424 9 9 .6 253 aa B 800 243 143 205 87.1 :140 aa E 800 243 1497 131 100.0 126 aa C 801 252 1563 255 100.0 252 aa A :*.802 165 1720 91 100.0 88 aa C 802 165 1718 99 9 2 7 82 aa E 803 171 1602 297 8 5 .5 159 aa E 804 62 1485 165 100.0 61 aa B 805 199 1514 219 100.0 199 aa B 806 131 1880 391 86.2:130 an E 807 101 1719 257 9 5.0 100 aa B 808 80 1585 263 9 8 .8 80Oaa B 809 447 1781 344 9 9 .7 331 aa D 809 447 1783 118 98.3 117 aa C 810 218 1564 250 100.0 :218 aa B 811 192 1478 408 99.5 192 aa B 812 341 1729 354 100.0 :340 aa B 813 201 1523 592 100.0 :158 an D 814 130 1769 306 92.3: 130 aa E 815 144 1835 548 78.4: 116 aa E 815 144 1815 377 84.3 :121 aa E 816 309 1894 3 10 100.0 :309 aa A 817 164 1823 156 96.7:153 aa D 818 54 1703 87 100.0 :53 aa B 819 202 1716 215 99.5 :202 aa B 820 169 1870 115 1 00 110aa D 821 186 1451 254 100.0 :186 aa B 822 72 1609 180 9 6 .6 :58 aa D 823 122 1633 664 9 4.9 :118 aa D 824 13 1695 70 100.0: 13 aa B 824 13) 1567 392 1 0 0 .0 13 aa B 825 99 1771 144 100.0 86 aa D 826 71 1512 154 9. 1a 827 150 1456 139 9.:17a 828 255 1651 155 100.0:155 aa C 828 255 1648 109 9 8 .0 102 aa D 829 106 1726 147 99.1 10 lOaa B 830 527 1509 567 99.8 524 aa B 831 124 1740 214 99.2:123 aa B 832 110 1690 400 98.2 110 aa B 833 326 1856 325 1 0 0.0O:325 aa C 834 253 1543 191 96.7 184 aa D 835 597 1876 63800.0:594 aa B 836 156 1621 345 99.4 154 aa B .837 157 1624 .253 9 7 4 :l15aa B 838 191 1465 241 96.8: 190aa B 839 90 1548 231 92.9 85 aa E 840 277 1682 298 99.6 :277 aa B 841 58 1508 270 98.1 :54 aa D 842 139 1734 139 88.4 129 aa E 843 279 1476 276 100.0 269 aa C 844 36 1852 83 94.4 36 aa B *845 129 1460 196 100.0:129 aa B *846 127 1473 172 100.0:105 aa D 847 276 1657 319 100.0:276 aa B 848 126 1801 187 98.4 126 aa B 849 242 1669 405 9 7 .0 :236 aa D 850 151 1816 217 100.0:151 aa B 851 154 1641 194 100.0 154 aa B 852 496 1665 327 9 7 .5 :314 aa C 853 179 1606 272 9 7 2 :179 aa B 855 160 1487 198 96.9:l160Oaa
B
856 94 1836 420 1 0 0 .0 :93 aa B 857 146 f845 371 99.3: 146 aa B 858 205 1507 366 98.5 :202 aa B 859 173 1827 198 1 0 0 .O0:149 aa D 860 193 1681 294 100.0 175 aa D 861 104 1865 253 100.0 104 aa B 862 355 1599 358 100.0 :355 aa B 863 93 1825 236 97.8 :92 aa B 864 82 1677 315 97.5 :81laa B 865 234 1861 249 99.1 233 aa B 866 239 1652 405 9 9.
2 :238 aa B 867 86 1468 201 7 7 .4 :84 aa E 868 289 1574 395 94.4 :284.aa E 869 436 1863 662 100.0 436 aa B 870 114 1560 121 100.0: 114 aa B 871 173 1757 362 98.8: 173 aa B 872 116 1866 145 98.1 105 aa D 873 127 1797 304 63.9 83 aa E 873 127 1799 270 89.7 :58 aa E 873 127 1800 62 97.4 :38 aa D 873 127 1801 187 82.0 50 aa E 874 150 1461 179 100.0 150 aa B 875 209 1511 339 98.9 188 aa D 876 234 1739 615 99.6 :230 aa B 877 395 1830 879 9 9.7 379 aa D 878 103 1623 413 97.0 99 aa D 879 265 1809 566 8 9.8 :265 aa B 880 364 1576 442 98.6 346 aa D IV. Identification of Nucleic Acids Encoding Vaccine Components and Targets for Agents Effective Against H. pylori The disclosed H. pylori genome sequence includes segments that direct the synthesis of ribonucleic acids and polypeptides, as well as origins of replication, promoters, other types of regulatory sequences, and intergenic nucleic acids. he invention encompasses nucleic acids encoding immunogenic components of vaccines and targets for agents effective against H. pylori. Identification of said immunogenic components involved in the determination of the function of the disclosed sequences, which can be 10 achieved using a variety of approaches. Non-limiting examples of these approaches are described briefly below.
Homology to known sequences: Computer-assisted comparison of the disclosed H.
pylori sequences with previously reported sequences present in publicly available databases is useful for identifying functional H. pylori nucleic acid and polypeptide sequences. It will be understood that protein-coding sequences, for example, may be compared as a whole, and that a high degree of sequence homology between two proteins (such as, for example, >80-90%) at the amino acid level indicates that the two proteins also possess some degree of functional homology, such as, for example, among enzymes involved in metabolism, DNA synthesis, or cell wall synthesis, and proteins involved in transport, cell division, etc.
In addition, many structural features of particular protein classes have been identified and correlate with specific consensus sequences, such as, for example, binding domains for nucleotides, DNA, metal ions, and other small molecules; sites for covalent modifications such as phosphorylation, acylation, and the like; sites of protein:protein interactions, etc.
These consensus sequences may be quite short and thus may represent only a fraction of the entire protein-coding sequence. Identification of such a feature in an H. pylori sequence is therefore useful in determining the function of the encoded protein and identifying useful targets of antibacterial drugs.
Of particular relevance to the present invention are structural features that are common to secretory, transmembrane, and surface proteins, including secretion signal peptides and hydrophobic transmembrane domains. H. pylori proteins identified as containing putative signal sequences and/or transmembrane domains are useful as immunogenic components of vaccines.
Identification of essential genes: Nucleic acids that encode proteins essential for growth or viability of H. pylori are preferred drug targets. H. pylori genes can be tested for their biological relevance to the organism by examining the effect of deleting and/or disrupting the genes, by so-called gene "knockout", using techniques known to those skilled in the relevant art. In this manner, essential genes may be identified.
Strain-specific sequences: Because of the evolutionary relationship between different H. pylori strains, it is believed that the presently disclosed H. pylori sequences are useful for identifying, and/or discriminating between, previously known and new H. pylori strains. It is believed that other H. pylori strains will exhibit at least 70% sequence homology with the presently disclosed sequence. Systematic and routine analyses of DNA sequences derived from samples containing H. pylori strains, and comparison with the present sequence allows for the identification of sequences that can be used to discriminate between strains, as well as those that are common to all H. pylori strains. In one embodiment, the invention provides nucleic acids, including probes, and peptide and polypeptide sequences that discriminate between different strains of H. pylori. Strainspecific components can also be identified functionally by their ability to elicit or react with 20 antibodies that selectively recognize one or more H. pylori strains.
In another embodiment, the invention provides nucleic acids, including probes, and peptide and polypeptide sequences that are common to all H. pylori strains but are not found in other bacterial species.
Specific Example: Determination Of Candidate Protein Antigens For Antibody And Vaccine Development The selection of candidate protein antigens for vaccine development can be derived from the nucleic acids encoding H. pylori polypeptides. First, the ORF's can be analyzed for homology to other known exported or membrane proteins and analyzed using the discriminant analysis described by Klein, et al. (Klein, Kanehsia, and DeLisi, C.
(1985) Biochimica et Biophysica Acta 815, 468-476) for predicting exported and membrane proteins.
Homology searches can be performed using the BLAST algorithm contained in the Wisconsin Sequence Analysis Package (Genetics Computer Group, University Research Park, 575 Science Drive, Madison, WI 53711) to compare each predicted ORF amino acid sequence with all sequences found in the current GenBank, SWISS-PROT and PIR databases. BLAST searches for local alignments between the ORF and the databank sequences and reports a probability score which indicates the probability of finding this sequence by chance in the database. ORF's with significant homology probabilities -73lower than lx10- 6 that the homology is only due to random chance) to membrane or exported proteins represent protein antigens for vaccine development. Possible functions can be provided to H. pylori genes based on sequence homology to genes cloned in other organisms.
Discriminant analysis (Klein, et al. supra) can be used to examine the ORF amino acid sequences. This algorithm uses the intrinsic information contained in the ORF amino acid sequence and compares it to information derived from the properties of known membrane and exported proteins. This comparison predicts which proteins will be exported, membrane associated or cytoplasmic. ORF amino acid sequences identified as exported or membrane associated by this algorithm are likely protein antigens for vaccine development.
Infrequently it is not possible to distinguish between multiple possible nucleotides at a given position in the nucleic acid sequence. In those cases the ambiguities are denoted by an extended alphabet as follows: These are the official IUPAC-IUB single-letter base codes
C.
S Code
G
A
T
C
R
Y
M
K
S
W
H
B
V
D
N
Base Description Guanine Adenine Thymine Cytosine Purine Pyrimidine Amino Ketone Strong interaction Weak interaction Not-G Not-A Not-T (not-U) Not-C Any (A or G) (C or T or U) (A or C) (G or T) (C or G) (A or T) (A or C or T) (C or G or T) (A or C or G) (A or G or T) (A or C or G or T) The amino acid translations of this invention account for the ambiguity in the nucleic acid sequence by translating the ambiguous codon as the letter In all cases, the permissible amino acid residues at a position are clear from an examination of the nucleic acid sequence based on the standard genetic code.
V. Production of Fragments and Analogs of H. pylori Nucleic Acids and Polvpeptides Based on the discovery of the H. pylori gene products of the invention provided in the Sequence Lsiting, one skilled in the art can alter the disclosed structure (ofH. pylori genes), by producing fragments or analogs, and test the newly produced structures for activity. Examples of techniques known to those skilled in the relevant art which allow the production and testing of fragments and analogs are discussed below. These, or analogous methods can be used to make and screen libraries of polypeptides, libraries of random peptides or libraries of fragments or analogs of cellular proteins for the ability to bind H.
pylori polypeptides. Such screens are useful for the identification of inhibitors of H. pylori.
Generation of Fragments Fragments of a protein can be produced in several ways, recombinantly, by proteolytic digestion, or by chemical synthesis. Internal or terminal fragments of a polypeptide can be generated by removing one or more nucleotides from one end (for a terminal fragment) or both ends (for an internal fragment) of a nucleic acid which encodes the polypeptide. Expression of the mutagenized DNA produces polypeptide fragments.
Digestion with "end-nibbling" endonucleases can thus generate DNA's which encode an array of fragments. DNA's which encode fragments of a protein can also be generated by random shearing, restriction digestion or a combination of the above-discussed methods.
20 Fragments can also be chemically synthesized using techniques known in the art such as conventional Merrifield solid phase f-Moc or t-Boc chemistry. For example, peptides of the present invention may be arbitrarily divided into fragments of desired length with no overlap of the fragments, or divided into overlapping fragments of a desired length.
9* Alteration of Nucleic Acids and Polvpeptides: Random Methods Amino acid sequence variants of a protein can be prepared by random mutagenesis of DNA which encodes a protein or a particular domain or region of a protein. Useful methods include PCR mutagenesis and saturation mutagenesis. A library of random amino acid sequence variants can also be generated by the synthesis of a set of degenerate oligonucleotide sequences. (Methods for screening proteins in a library of variants are elsewhere herein).
PCR Mutagenesis In PCR mutagenesis, reduced Taq polymerase fidelity is used to introduce random mutations into a cloned fragment of DNA (Leung et al., 1989, Technique 1:11-15). The DNA region to be mutagenized is amplified using the polymerase chain reaction (PCR) under conditions that reduce the fidelity of DNA synthesis by Taq DNA polymerase, e.g., by using a dGTP/dATP ratio of five and adding Mn 2 to the PCR reaction. The pool of amplified DNA fragments are inserted into appropriate cloning vectors to provide random mutant libraries.
Saturation Mutagenesis Saturation mutagenesis allows for the rapid introduction of a large number of single base substitutions into cloned DNA fragments (Mayers et al.. 1985, Science 229:242). This technique includes generation of mutations, by chemical treatment or irradiation of single-stranded DNA in vitro, and synthesis of a complimentary DNA strand. The mutation frequency can be modulated by modulating the severity of the treatment, and essentially all possible base substitutions can be obtained. Because this procedure does not involve a genetic selection for mutant fragments both neutral substitutions, as well as those that alter function, are obtained. The distribution of point mutations is not biased toward conserved sequence elements.
Degenerate Oligonucleotides A library of homologs can also be generated from a set of degenerate oligonucleotide sequences. Chemical synthesis of a degenerate sequences can be carried out in an automatic DNA synthesizer, and the synthetic genes then ligated into an appropriate expression vector. The synthesis of degenerate oligonucleotides is known in the art (see for example, Narang, SA (1983) Tetrahedron 39:3; Itakura et al. (1981) Recombinant DNA, Proc 3rd Cleveland Sympos. Macromolecules, ed. AG Walton, Amsterdam: Elsevier pp273-289; Itakura et al. (1984) Annu. Rev. Biochem. 53:323; Itakura et al. (1984) Science 198:1056; Ike et al. (1983) Nucleic Acid Res. 11:477. Such techniques 20 have been employed in the directed evolution of other proteins (see, for example, Scott et al. (1990) Science 249:386-390; Roberts et al. (1992) PNAS 89:2429-2433; Devlin et al.
(1990) Science 249: 404-406; Cwirla et al. (1990) PNAS 87: 6378-6382; as well as U.S.
Patents Nos. 5.223,409, 5,198,346, and 5,096,815).
o 25 Alteration of Nucleic Acids and Polvpeptides: Methods for Directed Mutagenesis Non-random or directed, mutagenesis techniques can be used to provide specific sequences or mutations in specific regions. These techniques can be used to create variants which include, deletions, insertions, or substitutions, of residues of the known amino acid sequence of a protein. The sites for mutation can be modified individually or in series, 30 by substituting first with conserved amino acids and then with more radical choices depending upon results achieved, deleting the target residue, or inserting residues of the same or a different class adjacent to the located site, or combinations of options 1-3.
Alanine Scanning Mutagenesis Alanine scanning mutagenesis is a useful method for identification of certain residues or regions of the desired protein that are preferred locations or domains for mutagenesis, Cunningham and Wells (Science 244:1081-1085, 1989). In alanine scanning, a residue or group of target residues are identified charged residues such as Arg, Asp, His, Lys, and Glu) and replaced by a neutral or negatively charged amino acid (most preferably alanine or polyalanine). Replacement of an amino acid can affect the interaction -76of the amino acids with the surrounding aqueous environment in or outside the cell. Those domains demonstrating functional sensitivity to the substitutions are then refined by introducing further or other variants at or for the sites of substitution. Thus. while the site for introducing an amino acid sequence variation is predetermined, the nature of the mutation per se need not be predetermined. For example, to optimize the performance of a mutation at a given site, alanine scanning or random mutagenesis may be conducted at the target codon or region and the expressed desired protein subunit variants are screened for the optimal combination of desired activity.
Olionucleotide-Mediated Mutagenesis Oligonucleotide-mediated mutagenesis is a useful method for preparing substitution, deletion, and insertion variants of DNA, see, Adelman et al., (DNA 2:183, 1983). Briefly, the desired DNA is altered by hybridizing an oligonucleotide encoding a mutation to a DNA template, where the template is the single-stranded form of a plasmid or bacteriophage containing the unaltered or native DNA sequence of the desired protein.
After hybridization, a DNA polymerase is used to synthesize an entire second coplilenntary strand uf the template that wil thus incorporate the oligonucleoide primer, and will code for the selected alteration in the desired protein DNA. Generally, oligonucleotides of at least 25 nucleotides in length are used. An optimal oligonucleotide *will have 12 to 15 nucleotides that are completely complementary to the template on either 20 side of the nucleotide(s) coding for the mutation. This ensures that the oligonucleotide will hybridize properly to the single-stranded DNA template molecule. The oligonucleotides are readily synthesized using techniques known in the art such as that described by Crea et al. (Proc. Natl. Acad. Sci. USA, 75: 5765[1978]).
Cassette Mutagenesis Another method for preparing variants, cassette mutagenesis. is based on the technique described by Wells et al. (Gene, 34:315[1985]). The starting material is a plasmid (or other vector) which includes the protein subunit DNA to be mutated. The codon(s) in the protein subunit DNA to be mutated are identified. There must be a unique restriction endonuclease site on each side of the identified mutation site(s). If no such restriction sites exist, they may be generated using the above-described oligonucleotidemediated mutagenesis method to introduce them at appropriate locations in the desired protein subunit DNA. After the restriction sites have been introduced into the plasmid, the plasmid is cut at these sites to linearize it. A double-stranded oligonucleotide encoding the sequence of the DNA between the restriction sites but containing the desired mutation(s) is synthesized using standard procedures. The two strands are synthesized separately and then hybridized together using standard techniques. This double-stranded oligonucleotide is referred to as the cassette. This cassette is designed to have 3' and 5' ends that are comparable with the ends of the linearized plasmid, such that it can be directly ligated to -77the plasmid. This plasmid now contains the mutated desired protein subunit DNA sequence.
Combinatorial Mutagenesis Combinatorial mutagenesis can also be used to generate mutants (Ladner et al., WO 88/06630). In this method, the amino acid sequences for a group of homologs or other related proteins are aligned, preferably to promote the highest homology possible. All of the amino acids which appear at a given position of the aligned sequences can be selected to create a degenerate set of combinatorial sequences. The variegated library of variants is generated by combinatorial mutagenesis at the nucleic acid level, and is encoded by a variegated gene library. For example, a mixture of synthetic oligonucleotides can be enzymatically ligated into gene sequences such that the degenerate set of potential sequences are expressible as individual peptides, or alternatively, as a set of larger fusion proteins containing the set of degenerate sequences.
Other Modifications ofH. pvlori Nucleic Acids and Polvpeptides It is possible to modify the structure of an H. pylori polypeptide for such purposes as increasing solubility, enhancing stability shelf life ex vivo and resistance to proteolytic degradation in vivo). A modified H. pylori protein or peptide can be produced in which the amino acid sequence has been altered, such as by amino acid substitution, 20 deletion, or addition as described herein.
An H. pylori peptide can also be modified by substitution of cysteine residues preferably with alanine, serine, threonine, leucine or glutamic acid residues to minimize dimerization via disulfide linkages. In addition, amino acid side chains of fragments of the protein of the invention can be chemically modified. Another modification is cyclization of the peptide.
In order to enhance stability and/or reactivity, an H. pylori polypeptide can be a. modified to incorporate one or more polymorphisms in the amino acid sequence of the protein resulting from any natural allelic variation. Additionally, D-amino acids, nonnatural amino acids, or non-amino acid analogs can be substituted or added to produce a 30 modified protein within the scope of this invention. Furthermore, an H. pylori polypeptide can be modified using polyethylene glycol (PEG) according to the method of A. Sehon and co-workers (Wie et al., supra) to produce a protein conjugated with PEG. In addition, PEG can be added during chemical synthesis of the protein. Other modifications of H. pylori proteins include reduction/alkylation (Tarr, Methods of Protein Microcharacterization, J. E.
Silver ed., Humana Press, Clifton NJ 155-194 (1986)); acylation (Tarr, supra); chemical coupling to an appropriate carrier (Mishell and Shiigi, eds, Selected Methods in Cellular Immunology, WH Freeman, San Francisco, CA (1980), U.S. Patent 4,939,239; or mild formalin treatment (Marsh, (1971) Int. Arch. ofAllergy andAppl. Immunol., 41: 199 215).
-78- To facilitate purification and potentially increase solubility of an H. pylori protein or peptide, it is possible to add an amino acid fusion moiety to the peptide backbone. For example, hexa-histidine can be added to the protein for purification by immobilized metal ion affinity chromatography (Hochuli, E. et al., (1988) Bio/Technology, 6: 1321 1325). In addition, to facilitate isolation of peptides free of irrelevant sequences, specific endoprotease cleavage sites can be introduced between the sequences of the fusion moiety and the peptide.
To potentially aid proper antigen processing of epitopes within an H. pylori polypeptide, canonical protease sensitive sites can be engineered between regions. each comprising at least one epitope via recombinant or synthetic methods. For example, charged amino acid pairs, such as KK or RR, can be introduced between regions within a protein or fragment during recombinant construction thereof. The resulting peptide can be rendered sensitive to cleavage by cathepsin and/or other trypsin-like enzymes which would generate portions of the protein containing one or more epitopes. In addition, such charged amino acid residues can result in an increase in the solubility of the peptide.
Primary Methods for Screening Polvpeptides and Analogs Various techniques are known in the art for screening generated mutant gene products. Techniques for screening large gene libraries often include cloning the gene 20 library into replicable expression vectors, transforming appropriate cells with the resulting library of vectors, and expressing the genes under conditions in which detection of a desired activity, in this case, binding to H. pylori polypeptide or an interacting protein, facilitates relatively easy isolation of the vector encoding the gene whose product was detected. Each of the techniques described below is amenable to high through-put analysis for screening large numbers of sequences created, by random mutagenesis techniques.
Two Hybrid Systems Two hybrid assays such as the system described above (as with the other screening methods described herein), can be used to identify polypeptides, fragments or analogs of a naturally-occurring H. pylori polypeptide. of cellular proteins, or of randomly generated polypeptides which bind to an H. pylori protein. (The H. pylori domain is used as the bait protein and the library of variants are expressed as fish fusion proteins.) In an analogous fashion, a two hybrid assay (as with the other screening methods described herein), can be used to find polypeptides which bind a H. pylori polypeptide.
Display Libraries In one approach to screening assays, the candidate peptides are displayed on the surface of a cell or viral particle, and the ability of particular cells or viral particles to bind an appropriate receptor protein via the displayed product is detected in a "panning assay".
For example, the gene library can be cloned into the gene for a surface membrane protein of a bacterial cell. and the resulting fusion protein detected by panning (Ladner et al., WO -79- 88/06630; Fuchs et al. (1991) Bio/Technology 9:1370-1371; and Goward et al. (1992) TIBS 18:136-140). In a similar fashion, a detectably labeled ligand can be used to score for potentially functional peptide homologs. Fluorescently labeled ligands. receptors. can be used to detect homologs which retain ligand-binding activity. The use of fluorescently labeled ligands, allows cells to be visually inspected and separated under a fluorescence microscope, or, where the morphology of the cell permits, to be separated by a fluorescence-activated cell sorter.
A gene library can be expressed as a fusion protein on the surface of a viral particle.
For instance, in the filamentous phage system, foreign peptide sequences can be expressed on the surface of infectious phage, thereby conferring two significant benefits. First, since these phage can be applied to affinity matrices at concentrations well over 1013 phage per milliliter, a large number of phage can be screened at one time. Second. since each infectious phage displays a gene product on its surface, if a particular phage is recovered from an affinity matrix in low yield, the phage can be amplified by another round of infection. The group of almost identical E. coli filamentous phages M13, fd., and fl are most often used in phage display libraries. Either of the phage gill or gVIII coat proteins can be used to generate tusion proteins without disrupting the ultimate packaging of the viral particle. Foreign epitopes can be expressed at the NH2-terminal end of pIII and phage bearing such epitopes recovered from a large excess of phage lacking this epitope (Ladner et al. PCT publication WO 90/02909; Garrard et al., PCT publication WO 92/09690; Marks et al. (1992) J. Biol. Chem. 267:16007-16010; Griffiths et al. (1993) EMBOJ 12:725-734; Clackson et al. (1991) Nature 352:624-628; and Barbas et al. (1992) PNAS 89:4457-4461).
A common approach uses the maltose receptor ofE. coli (the outer membrane protein, LamB) as a peptide fusion partner (Charbit et al. (1986) EMBO 5, 3029-3037).
25 Oligonucleotides have been inserted into plasmids encoding the LamB gene to produce peptides fused into one of the extracellular loops of the protein. These peptides are available for binding to ligands, to antibodies, and can elicit an immune response when the cells are administered to animals. Other cell surface proteins, OmpA (Schorr et al.
(1991) Vaccines 91, pp. 387-392), PhoE (Agterberg, et al. (1990) Gene 88, 37-45), and 30 PAL (Fuchs et al. (1991) Bio/Tech 9, 1369-1372), as well as large bacterial surface structures have served as vehicles for peptide display. Peptides can be fused to pilin, a protein which polymerizes to form the pilus-a conduit for interbacterial exchange of genetic information (Thiry et al. (1989) Appl. Environ. Microbiol. 55, 984-993). Because of its role in interacting with other cells, the pilus provides a useful support for the presentation of peptides to the extracellular environment. Another large surface structure used for peptide display is the bacterial motive organ, the flagellum. Fusion of peptides to the subunit protein flagellin offers a dense array of many peptide copies on the host cells (Kuwajima et al. (1988) Bio/Tech. 6, 1080-1083). Surface proteins of other bacterial species have also served as peptide fusion partners. Examples include the Staphylococcus protein A and the outer membrane IgA protease of Neisseria (Hansson et al. (1992) J.
Bacteriol. 174, 4239-4245 and Klauser et al. (1990) EMBO J. 9, 1991-1999).
In the filamentous phage systems and the LamB system described above, the physical link between the peptide and its encoding DNA occurs by the containment of the DNA within a particle (cell or phage) that carries the peptide on its surface. Capturing the peptide captures the particle and the DNA within. An alternative scheme uses the DNAbinding protein Lacl to form a link between peptide and DNA (Cull et al. (1992) PNAS USA 89:1865-1869). This system uses a plasmid containing the LacI gene with an oligonucleotide cloning site at its 3'-end. Under the controlled induction by arabinose, a LacI-peptide fusion protein is produced. This fusion retains the natural ability of LacI to bind to a short DNA sequence known as LacO operator (LacO). By installing two copies of LacO on the expression plasmid, the Lac-peptide fusion binds tightly to the plasmid that encoded it. Because the plasmids in each cell contain only a single oligonucleotide sequence and each cell expresses only a single peptide sequence, the peptides become specifically and stably associated with the DNA sequence that directed its synthesis. The c1 lsru f ib,r-r nar 1--tly lyran A +I-t peptlde TA ;A-x1 arA x -ro-4 t^ a mriV L113 I. Lil. ILU L t u tl J IJ'.U UIU'. .IlA t.'CLI1 C1EtJfk AJlOlL J (AJ L J of immobilized receptor to recover the complexes containing active peptides. The associated plasmid DNA is then reintroduced into cells for amplification and DNA sequencing to determine the identity of the peptide ligands. As a demonstration of the 20 practical utility of the method, a large random library of dodecapeptides was made and selected on a monoclonal antibody raised against the opioid peptide dynorphin B. A cohort of peptides was recovered, all related by a consensus sequence corresponding to a sixresidue portion of dynorphin B. (Cull et al. (1992) Proc. Natl. Acad. Sci. U.S.A. 89-1869) This scheme, sometimes referred to as peptides-on-plasmids, differs in two important ways from the phage display methods. First, the peptides are attached to the Cterminus of the fusion protein, resulting in the display of the library members as peptides having free carboxy termini. Both of the filamentous phage coat proteins, pill and pVIII, are anchored to the phage through their C-termini, and the guest peptides are placed into the outward-extending N-terminal domains. In some designs, the phage-displayed peptides are presented right at the amino terminus of the fusion protein. (Cwirla, et al. (1990) Proc.
Natl. Acad. Sci. U.S.A. 87, 6378-6382) A second difference is the set of biological biases affecting the population of peptides actually present in the libraries. The Lad fusion molecules are confined to the cytoplasm of the host cells. The phage coat fusions are exposed briefly to the cytoplasm during translation but are rapidly secreted through the inner membrane into the periplasmic compartment, remaining anchored in the membrane by their C-terminal hydrophobic domains, with the N-termini, containing the peptides, protruding into the periplasm while awaiting assembly into phage particles. The peptides in the LacI and phage libraries may differ significantly as a result of their exposure to different proteolytic activities. The phage coat proteins require transport across the inner -81membrane and signal peptidase processing as a prelude to incorporation into phage.
Certain peptides exert a deleterious effect on these processes and are underrepresented in the libraries (Gallop et al. (1994) J. Med. Chem. 37(9):1233-1251). These particular biases are not a factor in the LacI display system.
The number of small peptides available in recombinant random libraries is enormous. Libraries of 107-109 independent clones are routinely prepared. Libraries as large as 1011 recombinants have been created, but this size approaches the practical limit for clone libraries. This limitation in library size occurs at the step of transforming the DNA containing randomized segments into the host bacterial cells. To circumvent this limitation, an in vitro system based on the display of nascent peptides in polysome complexes has recently been developed. This display library method has the potential of producing libraries 3-6 orders of magnitude larger than the currently available phage/phagemid or plasmid libraries. Furthermore, the construction of the libraries, expression of the peptides, and screening, is done in an entirely cell-free format.
In one application of this method (Gallop et al. (1994) J. Med. Chem. 37(9):1233- 1251), a molecular DNA library encoding 1012 decapeptides was constructed and the library expressed in an E. coli S30 in vitro coupled transcription/translation system.
Conditions were chosen to stall the ribosomes on the mRNA, causing the accumulation of a substantial proportion of the RNA in polysomes and yielding complexes containing nascent 20 peptides still linked to their encoding RNA. The polysomes are sufficiently robust to be affinity purified on immobilized receptors in much the same way as the more conventional recombinant peptide display libraries are screened. RNA from the bound complexes is recovered, converted to cDNA, and amplified by PCR to produce a template for the next round of synthesis and screening. The polysome display method can be coupled to the 25 phage display system. Following several rounds of screening, cDNA from the enriched pool of polysomes was cloned into a phagemid vector. This vector serves as both a peptide I" expression vector, displaying peptides fused to the coat proteins, and as a DNA sequencing 006 vector for peptide identification. By expressing the polysome-derived peptides on phage, one can either continue the affinity selection procedure in this format or assay the peptides 30 on individual clones for binding activity in a phage ELISA, or for binding specificity in a completion phage ELISA (Barret, et al. (1992) Anal. Biochem 204,357-364). To identify the sequences of the active peptides one sequences the DNA produced by the phagemid host.
Secondary Screening of Polvpeptides and Analogs The high through-put assays described above can be followed by secondary screens in order to identify further biological activities which will, allow one skilled in the art to differentiate agonists from antagonists. The type of a secondary screen used will depend on the desired activity that needs to be tested. For example, an assay can be developed in -82which the ability to inhibit an interaction between a protein of interest and its respective ligand can be used to identify antagonists from a group of peptide fragments isolated though one of the primary screens described above.
Therefore, methods for generating fragments and analogs and testing them for activity are known in the art. Once the core sequence of interest is identified, it is routine for one skilled in the art to obtain analogs and fragments.
Peptide Mimetics of H. pylori Polvpeptides The invention also provides for reduction of the protein binding domains of the subject H. pylori polypeptides to generate mimetics, e.g. peptide or non-peptide agents.
The peptide mimetics are able to disrupt binding of a polypeptide to its counter ligand, e.g., in the case of an H. pylori polypeptide binding to a naturally occurring ligand. The critical residues of a subject H. pylori polypeptide which are involved in molecular recognition of a polypeptide can be determined and used to generate H. pylori-derived peptidomimetics which competitively or noncompetitively inhibit binding of the H. pylori polypeptide with an int.r.cti.n. l ti s f xanpl, Europan pautent applications -t 1. ULt" S" and EP-B31,080A).
For example, scanning mutagenesis can be used to map the amino acid residues of a particular H. pylori polypeptide involved in binding an interacting polypeptide, 20 peptidomimetic compounds diazepine or isoquinoline derivatives) can be generated which mimic those residues in binding to an interacting polypeptide, and which therefore can inhibit binding of an H. pylori polypeptide to an interacting polypeptide and thereby interfere with the function of H. pylori polypeptide. For instance, non-hydrolyzable peptide analogs of such residues can be generated using benzodiazepine see Freidinger et al.
25 in Peptides: Chemistry and Biology, G.R. Marshall ed., ESCOM Publisher: Leiden.
Netherlands. 1988), azepine see Huffman et al. in Peptides: Chemistry and Biology, G.R. Marshall ed.. ESCOM Publisher: Leiden, Netherlands. 1988), substituted gama lactam S. rings (Garvey et al. in Peptides: Chemistry and Biology, G.R. Marshall ed., ESCOM Publisher: Leiden. Netherlands, 1988), keto-methylene pseudopeptides (Ewenson et al.
(1986) J Med Chem 29:295; and Ewenson et al. in Peptides: Structure and Function (Proceedings of the 9th American Peptide Symposium) Pierce Chemical Co. Rockland, IL, 1985), P-tum dipeptide cores (Nagai et al. (1985) Tetrahedron Lett 26:647; and Sato et al.
(1986) J Chem Soc Perkin Trans 1:1231), and P-aminoalcohols (Gordon et al. (1985) Biochem Biophys Res Commun 26:419; and Dann et al. (1986) Biochem Biophys Res Commun 134:71).
I
-83- VI. Vaccine Formulations for H. pvlori Nucleic Acids and Polypeptides This invention also features vaccine compositions for protection against infection by H. pylori or for treatment of H pylori infection, a gram-negative spiral microaerophilic bacterium. In one embodiment, the vaccine compositions contain one or more immunogenic components such as a surface protein from H. pylori, or portion thereof, and a pharmaceutically acceptable carrier. Nucleic acids within the scope of the invention are exemplified by the nucleic acids of the invention contained in the Sequence Listing which encode H. pylori surface proteins. For example, the preferred nucleic acid for a vaccine composition of the invention is isolated from the group of nucleic acids which encode cell envelope proteins as outlined in Table 1. More specifically, the amino acids of SEQ ID NO:812, SEQ ID NO:820, SEQ ID NO:880, SEQ ID NO:658, SEQ ID NO:865, SEQ ID NO:1729, SEQ ID NO:1861, or fragments thereof, can be used alone or in combination for the formulation of vaccine compositions of the invention, as well as, their corresponding nucleic acids of SEQ ID NO:977, SEQ ID NO:978, SEQ ID NO:994, SEQ ID NO:215, SEQ ID NO:989, SEQ ID NO:1278, and SEQ ID NO:1410. However, any nucleic acid encoding an immunogenic H. pylori protein, or portion thereof, which is capable of expression in a cell, can be used in the present invention. These vaccines have therapeutic and prophylactic utilities.
0 One aspect of the invention provides a vaccine composition for protection against infection by H. pylori which contains at least one immunogenic fragment of an H. pylori protein and a pharmaceutically acceptable carrier. Preferred fragments include peptides of at least about 10 amino acid residues in length, preferably about 10-20 amino acid residues S" in length, and more preferably about 12-16 amino acid residues in length.
00° Immunogenic components of the invention can be obtained, for example, by screening polypeptides recombinantly produced from the corresponding fragment of the nucleic acid encoding the full-length H. pylori protein. In addition, fragments can be chemically synthesized using techniques known in the art such as conventional Merrifield solid phase f-Moc or t-Boc chemistry.
In one embodiment, immunogenic components are identified by the ability of the peptide to stimulate T cells. Peptides which stimulate T cells, as determined by, for example, T cell proliferation or cytokine secretion are defined herein as comprising at least one T cell epitope. T celt epitopes are believed to be involved in initiation and perpetuation of the immune response to the protein allergen which is responsible for the clinical symptoms of allergy. These T cell epitopes are thought to trigger early events at the level of the T helper cell by binding to an appropriate HLA molecule on the surface of an antigen presenting cell, thereby stimulating the T cell subpopulation with the relevant T cell receptor for the epitope. These events lead to T cell proliferation, lymphokine secretion, local inflammatory reactions, recruitment of additional immune cells to the site of antigen/T cell interaction, and activation of the B cell cascade, leading to the production of -84antibodies. A T cell epitope is the basic element, or smallest unit of recognition by a T cell receptor, where the epitope comprises amino acids essential to receptor recognition approximately 6 or 7 amino acid residues). Amino acid sequences which mimic those of the T cell epitopes are within the scope of this invention.
Screening immunogenic components can be accomplished using one or more of several different assays. For example, in vitro, peptide T cell stimulatory activity is assayed by contacting a peptide known or suspected of being immunogenic with an antigen presenting cell which presents appropriate MHC molecules in a T cell culture. Presentation of an immunogenic H. pylori peptide in association with appropriate MHC molecules to T cells in conjunction with the necessary costimulation has the effect of transmitting a signal to the T cell that induces the production of increased levels of cytokines, particularly of interleukin-2 and interleukin-4. The culture supernatant can be obtained and assayed for interleukin-2 or other known cytokines. For example, any one of several conventional assays for interleukin-2 can be employed, such as the assay described in Proc. Natl. Acad.
Sci USA, 86: 1333 (1989) the pertinent portions of which are incorporated herein by reference. A kit for an assav for the pnroti n ofterrn t is also available from Genzyme Corporation (Cambridge, MA).
Alternatively, a common assay for T cell proliferation entails measuring tritiated thymidine incorporation. The proliferation of T cells can be measured in vitro by 20 determining the amount of 3 H-labeled thymidine incorporated into the replicating DNA of cultured cells. Therefore, the rate of DNA synthesis and, in turn, the rate of cell division can be quantified.
Vaccine compositions of the invention containing immunogenic components H. pylori polypeptide or fragment thereof or nucleic acid encoding an H. pylori polypeptide 25 or fragment thereof) preferably include a pharmaceutically acceptable carrier. The term "pharmaceutically acceptable carrier" refers to a carrier that does not cause an allergic reaction or other untoward effect in patients to whom it is administered. Suitable pharmaceutically acceptable carriers include, for example, one or more of water, saline, phosphate buffered saline, dextrose, glycerol, ethanol and the like, as well as combinations thereof. Pharmaceutically acceptable carriers may further comprise minor amounts of auxiliary substances such as wetting or emulsifying agents, preservatives or buffers, which enhance the shelf life or effectiveness of the antibody. For vaccines of the invention containing H. pylori polypeptides, the polypeptide is coadministered with a suitable adjuvant.
It will be apparent to those of skill in the art that the therapeutically effective amount of DNA or protein of this invention will depend, inter alia, upon the administration schedule, the unit dose of antibody administered, whether the protein or DNA is administered in combination with other therapeutic agents, the immune status and health of the patient, and the therapeutic activity of the particular protein or DNA.
Vaccine compositions are conventionally administered parenterally, by injection, either subcutaneously or intramuscularly. Methods for intramuscular immunization are described by Wolff et al. (1990) Science 247: 1465-1468 and by Sedegah et al. (1994) Immunology 91: 9866-9870. Other modes of administration include oral and pulmonary formulations, suppositories, and transdermal applications. Oral immunization is preferred over parenteral methods for inducing protection against infection by H. pylori.
Czinn et. al. (1993) Vaccine 11: 637-642. Oral formulations include such normally employed excipients as, for example, pharmaceutical grades of mannitol, lactose, starch.
magnesium stearate, sodium saccharine, cellulose, magnesium carbonate, and the like.
The vaccine compositions of the invention can include an adjuvant, including, but not limited to aluminum hydroxide; N-acetyl-muramyl--L-threonyl-D-isoglutamine (thr- MDP); N-acetyl-nor-muramyl-L-alanyl-D-isoglutamine (CGP 11637, referred to as nor- MDP); N-acetylmuramyl-L-alanyl-D-isoglutaminyl-L-alanine-2-( 1 '-2'-dipalmitoyl-snglycero-3-hydroxyphos-phoryloxy)-ethylamine (CGP 19835A, referred to a MTP-PE); RIBI, which contains three components from bacteria; monophosphoryl lipid A; trehalose dimycoloate; cell wall skeleton (MPL TDM CWS) in a 2% squalene/Tween emulsion; and cholera toxin. Others which may be used are non-toxic derivatives of cholera toxin, including its B subunit, and/or conjugates or genetically engineered fusions of the H. pylori polypeptide with cholera toxin or its B subunit, procholeragenoid, fungal 20 polysaccharides, including schizophyllan, muramyl dipeptide, muramyl dipeptide derivatives, phorbol esters, labile toxin of E. coli, non-H. pylori bacterial lysates, block polymers or saponins.
Other suitable delivery methods include biodegradable microcapsules or immunostimulating complexes (ISCOMs), cochleates, or liposomes, genetically engineered attenuated live vectors such as viruses or bacteria, and recombinant (chimeric) virus-like particles, bluetongue. The amount of adjuvant employed will depend on the type of adjuvant used. For example, when the mucosal adjuvant is cholera toxin, it is suitably used in an amount of 5 ig to 50 ig, for example 10 ag to 35 g. When used in the form of microcapsules, the amount used will depend on the amount employed in the matrix of the microcapsule to achieve the desired dosage. The determination of this amount is within the skill of a person of ordinary skill in the art.
Carrier systems in-humans may include enteric release capsules protecting the antigen from the acidic environment of the stomach, and including H. pylori polypeptide in an insoluble form as fusion proteins. Suitable carriers for the vaccines of the invention are enteric coated capsules and polylactide-glycolide microspheres. Suitable diluents are 0.2 N NaHCO3 and/or saline.
Vaccines of the invention can be administered as a primary prophylactic agent in adults or in children, as a secondary prevention, after successful eradication of H. pylori in an infected host, or as a therapeutic agent in the aim to induce an immune response in a
I
susceptible host to prevent infection by H. pylori. The vaccines of the invention are administered in amounts readily determined by persons of ordinary skill in the art. Thus, for adults a suitable dosage will be in the range of 10 Lg to 10 g, preferably 10 pg to 100 mg, for example 50 pg to 50 mg. A suitable dosage for adults will also be in the range of pg to 500 mg. Similar dosage ranges will be applicable for children. Those skilled in the art will recognize that the optimal dose may be more or less depending upon the patient's body weight, disease, the route of administration, and other factors. Those skilled in the art will also recognize that appropriate dosage levels can be obtained based on results with known oral vaccines such as, for example, a vaccine based on an E. coli lysate (6 mg dose daily up to total of 540 mg) and with an enterotoxigenic E. coli purified antigen (4 doses of 1 mg) (Schulman et al., J. Urol. 150:917-921 (1993); Boedecker et al., American Gastroenterological Assoc. 999:A-222 (1993)). The number of doses will depend upon the disease, the formulation. and efficacy data from clinical trials. Without intending any limitation as to the course of treatment, the treatment can be administered over 3 to 8 doses for a primary immunization schedule over 1 month (Boedeker, American Gasiroenteroiogicai Assoc. 888:A-222 (1993)).
In a preferred embodiment, a vaccine composition of the invention can be based on a killed whole E. coli preparation with an immunogenic fragment of an H. pylori protein of the invention expressed on its surface or it can be based on an E. coli lysate. wherein the 20 killed E. coli acts as a carrier or an adjuvant.
It will be apparent to those skilled in the art that some of the vaccine compositions of the invention are useful only for preventing H. pylori infection, some are useful only for treating H. pylori infection, and some are useful for both preventing and treating H. pylori infection. In a preferred embodiment, the vaccine composition of the invention provides 25 protection against H. pylori infection by stimulating humoral and/or cell-mediated immunity against H. pylori. It should be understood that amelioration of any of the symptoms ofH. pylori infection is a desirable clinical goal, including a lessening of the dosage of medication used to treat H. pylori-caused disease, or an increase in the production of antibodies in the serum or mucous of patients.
VII. Antibodies Reactive With H. ovlori Polvpeptides The invention also includes antibodies specifically reactive with the subject H.
pylori polypeptide. Anti-protein/anti-peptide antisera or monoclonal antibodies can be made by standard protocols (See, for example, Antibodies: A Laboratory Manual ed. by Harlow and Lane (Cold Spring Harbor Press: 1988)). A mammal such as a mouse, a hamster or rabbit can be immunized with an immunogenic form of the peptide. Techniques for conferring immunogenicity on a protein or peptide include conjugation to carriers or other techniques well known in the art. An immunogenic portion of the subject H. pylori polypeptide can be administered in the presence of adjuvant. The progress of immunization -87can be monitored by detection of antibody titers in plasma or serum. Standard ELISA or other immunoassays can be used with the immunogen as antigen to assess the levels of antibodies.
In a preferred embodiment, the subject antibodies are immunospecific for antigenic determinants of the H. pylori polypeptides of the invention, e.g. antigenic determinants of a polypeptide of the invention contained in the Sequence Listing, or a closely related human or non-human mammalian homolog 90% homologous, more preferably at least homologous). In yet a further preferred embodiment of the invention, the anti-H. pylori antibodies do not substantially cross react react specifically) with a protein which is for example, less than 80% percent homologous to a sequence of the invention contained in the Sequence Listing. By "not substantially cross react", it is meant that the antibody has a binding affinity for a non-homologous protein which is less than 10 percent, more preferably less than 5 percent, and even more preferably less than 1 percent, of the binding affinity for a protein of the invention contained in the Sequence Listing. In a most preferred embodiment, there is no crossreactivity between bacterial and mammalian antigens.
The term antibody as used herein is intended to include fragments thereof which are also specifically reactive with H. pylori polypeptides. Antibodies can be fragmented using conventional techniques and the fragments screened for utility in the same manner as 20 described above for whole antibodies. For example, F(ab') 2 fragments can be generated by treating antibody with pepsin. The resulting F(ab') 2 fragment can be treated to reduce disulfide bridges to produce Fab' fragments. The antibody of the invention is further intended to include bispecific and chimeric molecules having an anti-H. pylori portion.
Both monoclonal and polyclonal antibodies (Ab) directed against H. pylori polypeptides or H. pylori polypeptide variants, and antibody fragments such as Fab' and F(ab') 2 can be used to block the action of H. pylori polypeptide and allow the study of the role of a particular H. pylori polypeptide of the invention in aberrant or unwanted intracellular signaling, as well as the normal cellular function of the H. pylori and by microinjection of anti-H. pylori polypeptide antibodies of the present invention.
Antibodies which specifically bind H. pylori epitopes can also be used in immunohistochemical staining of tissue samples in order to evaluate the abundance and pattern of expression of H. pylori antigens. Anti H. pylori polypeptide antibodies can be used diagnostically in immuno-precipitation and immuno-blotting to detect and evaluate H.
pylori levels in tissue or bodily fluid as part of a clinical testing procedure. Likewise, the ability to monitor H. pylori polypeptide levels in an individual can allow determination of the efficacy of a given treatment regimen for an individual afflicted with such a disorder.
The level of an H. pylori polypeptide can be measured in cells found in bodily fluid, such as in urine samples or can be measured in tissue, such as produced by gastric biopsy.
Diagnostic assays using anti-H, pylori antibodies can include, for example, immunoassays
I
-88designed to aid in early diagnosis of H. pylori infections. The present invention can also be used as a method of detecting antibodies contained in samples from individuals infected by this bacterium using specific H. pylori antigens.
Another application of anti-H. pylori polypeptide antibodies of the invention is in the immunological screening of cDNA libraries constructed in expression vectors such as Xgtl 1, Xgtl 8-23, XZAP, and .ORF8. Messenger libraries of this type, having coding sequences inserted in the correct reading frame and orientation, can produce fusion proteins. For instance, Xgtl 1 will produce fusion proteins whose amino termini consist of B-galactosidase amino acid sequences and whose carboxy termini consist of a foreign polypeptide. Antigenic epitopes of a subject H. pylori polypeptide can then be detected with antibodies, as, for example, reacting nitrocellulose filters lifted from infected plates with anti-H. pylori polypeptide antibodies. Phage, scored by this assay, can then be isolated from the infected plate. Thus, the presence ofH. pylori gene homologs can be detected and cloned from other species, and alternate isoforms (including splicing variants) can be detected and cloned.
VIII. Kits Containing Nucleic Acids. Polvpeptides or Antibodies of the Invention The nucleic acid, polypeptides and antibodies of the invention can be combined with other reagents and articles to form kits. Kits for diagnostic purposes typically 20 comprise the nucleic acid, polypeptides or antibodies in vials or other suitable vessels. Kits typically comprise other reagents for performing hybridization reactions, polymerase chain reactions (PCR), or for reconstitution of lyophilized components, such as aqueous media, S salts, buffers, and the like. Kits may also comprise reagents for sample processing such as detergents, chaotropic salts and the like. Kits may also comprise immobilization means 25 such as particles, supports, wells, dipsticks and the like. Kits may also comprise labeling means such as dyes, developing reagents, radioisotopes, fluorescent agents. luminescent or chemiluminescent agents, enzymes, intercalating agents and the like. With the nucleic acid and amino acid sequence information provided herein, individuals skilled in art can readily assemble kits to serve their particular purpose. Kits further can include instructions for use.
IX. Drug Screening Assays Using H. ylori Polypeptides By making available purified and recombinant H. pylori polypeptides. the present invention provides assays which can be used to screen for drugs which are either agonists or antagonists of the normal cellular function, in this case, of the subject H. pylori polypeptides, or of their role in intracellular signaling. Such inhibitors or potentiators may be useful as new therapeutic agents to combat H. pylori infections in humans. A variety of assay formats will suffice and, in light of the present inventions, will be comprehended by the skilled artisan.
I
In many drug screening programs which test libraries of compounds and natural extracts, high throughput assays are desirable in order to maximize the number of compounds surveyed in a given period of time. Assays which are performed in cell-free systems, such as may be derived with purified or semi-purified proteins, are often preferred as "primary" screens in that they can be generated to permit rapid development and relatively easy detection of an alteration in a molecular target which is mediated by a test compound. Moreover, the effects of cellular toxicity and/or bioavailability of the test compound can be generally ignored in the in vitro system, the assay instead being focused primarily on the effect of the drug on the molecular target as may be manifest in an alteration of binding affinity with other proteins or change in enzymatic properties of the molecular target. Accordingly, in an exemplary screening assay of the present invention, the compound of interest is contacted with an isolated and purified H. pylori polypeptide.
Screening assays can be constructed in vitro with a purified H. pylori polypeptide or fragment thereof, such as an H. pylori polypeptide having enzymatic activity, such that the activity of the polypeptide produces a detectable reaction product. The efficacy of the compound can be assessed by generating dose response curves from data obtained using various concentrations of the test compound. Moreover, a control assay can also be performed to provide a baseline for comparison. Suitable products include those with distinctive absorption, fluorescence, or chemi-luminescence properties. for example, because detection may be easily automated. A variety of synthetic or naturally occurring i compounds can be tested in the assay to identify those which inhibit or potentiate the activity of the H. pylori polypeptide. Some of these active compounds may directly, or with chemical alterations to promote membrane permeability or solubility, also inhibit or potentiate the same activity enzymatic activity) in whole, live H. pylori cells.
EXEMPLIFICATION
I. Cloning and Sequencing ofH. pylori DNA H. pylori chromosomal DNA was isolated according to a basic DNA protocol outlined in Schleif R.F. and Wensink Practical Methods in Molecular Biology, p.98, Springer-Verlag, NY., 1981, with minor modifications. Briefly, cells were pelleted, resuspended in TE (10 mM Tris, 1 mM EDTA, pH 7.6) and GES lysis buffer (5.1 M guanidium thiocyanate, 0.1 M EDTA, pH 8.0, 0.5% N-laurylsarcosine) was added.
Suspension was chilled and ammonium acetate (NH 4 Ac) was added to final concentration of 2.0 M. DNA was extracted, first with chloroform, then with phenol-chloroform, and reextracted with chloroform. DNA was precipitated with isopropanol. washed twice with EtOH. dried and resuspended in TE.
Following isolation whole genomic H. pylori DNA was nebulized (Bodenteich et al.. Automated DNA Sequencing and Analysis Venter. Academic Press, 1994) to a median size of 2000 bp. After nebulization, the DNA was concentrated and separated on a standard 1% agarose gel. Several fractions, corresponding to approximate sizes 900-1300 bp, 1300-1700 bp, 1700-2200 bp, 2200-2700 bp, were excised from the gel and purified by the GeneClean procedure (Bioll01, Inc.).
The purified DNA fragments were then blunt-ended using T4 DNA polymerase.
The healed DNA was then ligated to unique BstXI-linker adapters TCTAGACCACCTGC and 5' GTGGTCTAGA in 100-1000 fold molar excess). These linkers are complimentary to the BstXI-cut pMPX vectors, while the overhang is not selfcomplimentary. Therefore, the linkers will not concatemerize nor will the cut-vector religate itself easily. The linker-adopted inserts were separated from the unincorporated linkers on a 1% agarose gel and purified using GeneClean. The linker-adopted inserts were then ligated to each of the 20 pMPX vectors to construct a series of "shotgun" subclone libraries. The vectors contain an out-of-frame lacZ gene at the cloning site which becomes in-frame in the event that an adapter-dimer is cloned, allowing these to be avoided by their blue-color.
f 'All subsequent steps were based on the multiplex DNA sequencing protocols outlined in Church G.M. and Kieffer-Higgins Science 240:185-188, 1988. Only major t'o modifications to the protocols are highlighted. Briefly, each of the 20 vectors was then transformed into DH5a competent cells (Gibco/BRL, DH5a transformation protocol). The 20 libraries were assessed by plating onto antibiotic plates containing ampicillin. methicillin and IPTG/Xgal. The plates were incubated overnight at 370C. Successful transformants "were then used for plating of clones and pooling into the multiplex pools. The clones were picked and pooled into 40 ml growth medium cultures. The cultures were grown overnight at 370C. DNA was purified using the Qiagen Midi-prep kits and Tip-100 columns 25 (Qiagen. Inc.). In this manner, 100 uLg of DNA was obtained per pool. Fifteen 96-well plates of DNA were generated to obtain a 5-10 fold sequence redundancy assuming 250- 300 base average read-lengths.
These purified DNA samples were then sequenced using the multiplex DNA sequencing based on chemical degradation methods (Church G.M. and Kieffer-Higgins S., Science 240:185-188, 1988) or by Sequithrem (Epicenter Technologies) dideoxy sequencing protocols. The sequencing reactions were electrophoresed and transferred onto nylon membranes by direct transfer electrophoresis from 40 cm gels (Richterich P. and Church Methods in Enzymology 218:187-222, 1993) or by electroblotting (Church, supra). 24 samples were run per gel. 45 successful membranes were produced by chemical sequencing and 8 were produced by dideoxy sequencing. The DNA was covalently bound to the membranes by exposure to ultraviolet light, and hybridized with labeled oligonucleotides complimentary to tag sequences on the vectors (Church, supra). The membranes were washed to rinse off non-specifically bound probe, and exposed to X-ray film to visualize individual sequence ladders. After autoradiography, the hybridized probe was removed by incubation at 65° C, and the hybridization cycle repeated with another tag sequence until the membrane had been probed 38 times for chemical sequencing membranes and 10 times for the dideoxy sequencing membranes. Thus, each gel produced a large number of films, each containing new sequencing information. Whenever a new blot was processed, it was initially probed for an internal standard sequence added to each of the pools.
Digital images of the films were generated using a laser-scanning densitometer (Molecular Dynamics, Sunnyvale, CA). The digitized images were processed on computer workstations (VaxStation 4000's) using the program REPLICATM (Church et al., Automated DNA Sequencing and Analysis Venter, Academic Press. 1994).
Image processing included lane straightening, contrast adjustment to smooth out intensity differences, and resolution enhancement by iterative gaussian deconvolution. The sequences were then automatically picked in REPLICATM and displayed for interactive proofreading before being stored in a project database. The proofreading was accomplished by a quick visual scan of the film image followed by mouse clicks on the bands of the displayed image to modify the base calls. Many of the sequence errors could be detected 00: and corrected because multiple sequence reads covering the same portion of the genomic DNA provide adequate sequence redundancy for editing. Each sequence automatically received an identification number (corresponding to microtiter plate, probe information, ;i 20 and lane set number). This number serves as a permanent identifier of the sequence so it is always possible to identify the original of any particular sequence without recourse to a specialized database.
f Routine assembly of H. pylori sequences was done using the program FALCON (Church, Church et al., Automated DNA Sequenicng and Analysis Venter. ed.), Academic Press, 1994). This program has proven to be fast and reliable for most lf o °sequences. The assembled contigs were displayed using a modified version of to&' GelAssemble, developed by the Genetics Computer Group (GCG) (Devereux et al., Nucleic Acid Res. 12:387-95, 1984) that interacts with REPLICA T M This provided for an integrated editor that allows multiple sequence gel images to be instantaneously called up from the REPLICA T M database and displayed to allow rapid scanning of contigs and proofreading of gel traces where discrepancies occurred between different sequence reads in the assembly.
II. Identification. cloning and expression of recombinant H. pyvlori DNA sequences To facilitate the cloning, expression and purification of membrane and secreted proteins from H. pylori a powerful gene expression system, the pET System (Novagen), for cloning and expression of recombinant proteins in E. coli, was selected. Also, a DNA sequence encoding a peptide tag, the His-Tag, was fused to the 3' end of DNA sequences of interest in order to facilitate purification of the recombinant protein products. The 3' end -92was selected for fusion in order to avoid alteration of any 5' terminal signal sequence. The exception to the above was ppiB, a gene cloned for use as a control in the expression studies. In this study, the sequence for H. pylori ppiB contains a DNA sequence encoding a His-Tag fused to the 5' end of the full length gene. because the protein product of this gene does not contain a signal sequence and is expressed as a cytosolic protein.
PCR Amplification and cloning ofDNA sequences containing ORF'sfor membrane and secreted proteins from the J99 Strain of Helicobacter pylori.
Sequences chosen (from the list of the DNA sequences of the invention) for cloning from the J99 strain of H. pylori were prepared for amplification cloning by polymerase chain reaction (PCR). Synthetic oligonucleotide primers (Table 4) specific for the 5' and 3' ends of open reading frames (ORFs) were designed and purchased (GibcoBRL Life Technologies, Gaithersburg, MD. USA). All forward primers (specific for the 5' end of the sequence) were designed to include an Ncol cloning site at the extreme 5' terminus, except for HpSeq. 4821082 (SEQ ID NO: 820) where NdeI was used. These primers were designed to permit initiation of protein translation at a methionine residue followed by a valine residue and the coding sequence for the remainder of the native H. pylori DNA sequence. An exception is H. pylori sequence 4821082 (SEQ ID NO: 820) where the initiator methionine is immediately followed by the remainder of the native H. pylori DNA 20 sequence. All reverse primers (specific for the 3' end of any H. pylori ORF) included a EcoRI site at the extreme 5' terminus to permit cloning of each H. pylori sequence into the reading frame of the pET-28b. The pET-28b vector provides sequence encoding an additional 20 carboxy-terminal amino acids (only 19 amino acids in HpSeq. 26380318 (SEQ ID NO: 658)and HpSeq.14640637 (SEQ ID NO: 447)) including six histidine residues (at the extreme C-terminus), which comprise the His-Tag. An exception to the above, as noted earlier, is the vector construction for the ppiB gene. A synthetic oligonucleotide primer specific for the 5' end of ppiB gene encoded a BamHI site at its extreme 5' terminus and the primer for the 3' end of the ppiB gene encoded a XhoI site at its extreme 5' terminus.
TABLE 4 U nvlnri DNA n1r1t~~~ Oli2onucleotide primers used for PCR amnlification ofH. nylori N sen"Pni-ge
S.
S
9 Outer membrane Proteins Forward primer 5' to 3' Reverse Primer 5' to 3' 16225006 (SEQ ID NO: 5'-TATACCATGGTGGG 465) CGCTAA-3' (SEQ ID GATTTTG--3' (SEQ ID NO: 1897) NO: 1898) 26054702 (SEQ ID NO: 5'-TTfAACCATGGTGAAA 649) AGCGATA-3 (SEQ ID GATCAATC-3 (SEQ ID NO: 1899) NO: 1900) 7116626 (SEQ ID NO: 865) 5'-ATATCCATGGTGAGT TrGATGA-3' (SEQ ID TATITIITTGCCA-3' (SEQ ID NO: 190 1) NO: 1902) 29479681 (SEQ ID NO: 5'-AATTCCATGGTGGGG 677) GCTATG-3' (SEQ ID CCAAAATC-3' (SEQ ID NO: 1903) NO: 1904) 14640637 (SEQ ID NO: 5'-AATITCCATGGTGCAT 447) AACTTfCCATT-3' (SEQ ID TCCAAATGGA-3' (SEQ 1905) ID NO: 1906) Periplasmic! Secreted Proteins 30100332 (SEQ ID NO: 5'-ATYITCCATGGTCATG 685) TCTCATATT-3' (SEQ ID TATrCCAC-3'(SEQ ID NO: 1907) -NO: 1908) 4721061 (SEQ ID NO: 812) 5'-AACCATGGTGATTT TAAGCATTGAAAG-3' AAAThTI1AACAG-3' ID NO: 1909) (SEQ ID NO: 1910) Other Surface Proteins 4821082 (SEQ ID NO: 820) 5'-GATCATCCATATGTT ATCTTrCTAAT-3- (SEQ ID TAACCCTG-3' (SEQ ID NO: 1911) NO: 1912) 978477 (SEQ ID NO: 880) 5'-TATACCATGGTGAA AThT=I I I IA-3' TCTTGTAAAAG-3* (SEQ (SEQ ID NO: 1913) ID NO: 1914) Inner Membrane Protein 26380318 (SEQ ID NO: 5'-TATACCATGGTGAT 658) GGACAAACTC-3-' (SEQ GGGGCGATA-3' (SEQ ID ID NO: 1915) NO: 1916) Cytoplasmic Protein ppi 5'-TTATGGATCCAAAC CAATTAAAACT-3 (SEQ GAGAAGGGC-3' (SEQ ID NO: 1917) NO: 1918)
S
S S Genomic DNA prepared from the J99 strain ofH. pylori (ATCC #55679) was used as the source of template DNA for PCR amplification reactions (Current Protocols in Molecular Biology, John Wiley and Sons, Inc., F. Ausubel et al., eds., 1994). To amplify a DNA sequence containing an H. pylori ORF, genomic DNA (50 nanograms) was introduced into a reaction vial containing 2 mM MgC12, 1 micromolar synthetic oligonucleotide primers (forward and reverse primers) complementary to and flanking a defined H. pylori ORF, 0.2 mM of each deoxynucleotide triphosphate; dATP, dGTP, dCTP, dTTP and 2.5 units of heat stable DNA polymerase (Amplitaq, Roche Molecular Systems, Inc., Branchburg, NJ, USA) in a final volume of 100 microliters. The following thermal cycling conditions were used to obtain amplified DNA products for each ORF using a Perkin Elmer Cetus/ GeneAmp PCR System 9600 thermal cycler: Sequences 26054702 (SEQ ID NO: 649), 7116626 (SEQ ID NO: 865), 29479681 (SEQ ID NO: 677), 30100332 (SEQ ID NO: 685), 4821082 (SEQ ID NO: 820) and 978477 (SEQ ID NO: 880); Denaturation at 94 0 C for 2 min, 2 cycles at 94 0 C for 15 sec, 30 0 C for 15 sec and 72 0 C for 1.5 min 23 cycles at 94 0 C for 15 sec, 55 0 C for 15 sec and 72 0 C for 1.5 min Reactions were concluded at 72 0 C for 6 minutes.
Sequence 16225006 (SEQ ID NO: 465); Denaturation at 94 0 C for 2 min, 25 cycles at 95 0 C for 15 sec. 55 0 C for 15 sec and 72 0 C for 1.5 min Reaction was concluded at 72 0 C for 6 minutes.
Sequence 4721061 (SEQ ID NO: 812); Denaturation at 94 0 C for 2 min.
2 cycles at 94 0 C for 15 sec. 36 0 C for 15 sec and 72 0 C for 1.5 min 23 cycles at 94 0 C for 15 sec. 60 0 C for 15 sec and 72 0 C for 1.5 min Reactions were concluded at 72 0 C for 6 minutes.
Sequence 26380318 (SEQ ID NO: 658); Denaturation at 94 0 C for 2 min.
2 cycles at 94 0 C for 15 sec. 38 0 C for 15 sec and 72 0 C for 1.5 min 23 cycles at 94 0 C for 15 sec, 62 0 C for 15 sec and 72 0 C for 1.5 min Reactions were concluded at 72 0 C for 6 minutes.
Sequence 14640637 (SEQ ID NO: 447); Denaturation at 94 0 C for 2 min.
2 cycles at 94 0 C for 15 sec, 33 0 C for 15 sec and 72 0 C for 1.5 min cycles at 94 0 C for 15 sec, 55 0 C for 15 sec and 72 0 C for 1.5 min Reactions were concluded at 72 0 C for 6 minutes.
Conditions for amplification ofH. pylori ppiB; Denaturation at 94 0 C for 2 min, 2 cycles at 94 0 C for 15 sec, 32 0 C for 15 sec and 72 0 C for 1.5 min 25 cycles at 94 0 C for 15 sec, 56 0 C for 15 sec and 72 0 C for 1.5 min Reactions were concluded at 72 0 C for 6 minutes Upon completion of thermal cycling reactions, each sample of amplified DNA was washed and purified using the Qiaquick Spin PCR purification kit (Qiagen, Gaithersburg, MD, USA). All amplified DNA samples were subjected to digestion with the restriction endonucleases, Ncol and EcoRI (New England BioLabs, Beverly, MA, USA), or in the case of HpSeq. 4821082 (SEQ ID NO: 820), with Ndel and EcoRI (Current Protocols in Molecular Biology, John Wiley and Sons, Inc., F. Ausubel et al., eds., 1994). DNA samples were then subjected to electrophoresis on 1.0 NuSeive (FMC BioProducts, S 20 Rockland, ME USA) agarose gels. DNA was visualized by exposure to ethidium bromide and long wave uv irradiation. DNA contained in slices isolated from the agarose gel was purified using the Bio 101 GeneClean Kit protocol (Bio 101 Vista, CA, USA) Cloning ofH. pylori DNA sequences into the pET-28b prokaryotic expression vector.
The pET-28b vector was prepared for cloning by digestion with NcoI and EcoRI, or in the case of H pylori sequence 4821082 (SEQ ID NO: 820) with NdeI and EcoRI (Current Protocols in Molecular Biology, John Wiley and Sons, Inc.. F. Ausubel et al., eds., 1994). In the case of cloning ppiB, the pET-28a vector, which encodes a His-Tag that can be fused to the 5' end of an inserted gene, was used and the cloning site prepared for 30 cloning with the ppiB gene by digestion with BamHI and Xhol restriction endonucleases.
Following digestion, DNA inserts were cloned (Current Protocols in Molecular Biology, John Wiley and Sons, Inc., F. Ausubel et al., eds., 1994) into the previously digested pET-28b expression vector, except for the amplified insert for ppiB, which was cloned into the pET-28a expression vector. Products of the ligation reaction were then used to transform the BL21 strain of E. coli (Current Protocols in Molecular Biology, John Wiley and Sons, Inc., F. Ausubel et al., eds., 1994) as described below.
Transformation of competent bacteria with recombinant plasmids Competent bacteria, E coli strain BL21 or E. coli strain BL21(DE3), were transformed with recombinant pET expression plasmids carrying the cloned H. pylori -96sequences according to standard methods (Current Protocols in Molecular. John Wiley and Sons, Inc.. F. Ausubel et al., eds., 1994). Briefly, 1 microliter of ligation reaction was mixed with 50 microliters of electrocompetent cells and subjected to a high voltage pulse, after which, samples were incubated in 0.45 milliliters SOC medium yeast extract, 2.0 tryptone, 10 mM NaCI, 2.5 mM KC1, 10 mM MgCl2, 10 mM MgSO4 and 20, mM glucose) at 37 0 C with shaking for 1 hour. Samples were then spread on LB agar plates containing 25 microgram/ml kanamycin sulfate for growth overnight. Transformed colonies of BL21 were then picked and analyzed to evaluate cloned inserts as described below.
Identification of recombinant pET expression plasmids carrying H. pylori sequences Individual BL21 clones transformed with recombinant pET-28b-H.pylori ORFs were analyzed by PCR amplification of the cloned inserts using the same forward and reverse primers, specific for each H. pylori sequence, that were used in the original PCR amplification cloning reactions. Successful amplification verified the integration of the H.
pylori sequences in the expression vector (Current Protocols in Molecular Biology, John Wiley and Sons, Inc., F. Ausubel et al., eds., 1994).
Isolation and Preparation ofplasmid DNA from BL21 transformants 20 Individual clones of recombinant pET-28b vectors carrying properly cloned H.
pylori ORFs were picked and incubated in 5 mis of LB broth plus 25 microgram/ml kanamycin sulfate overnight. The following day plasmid DNA was isolated and purified using the Qiagen plasmid purification protocol (Qiagen Inc., Chatsworth, CA, USA).
Expression of recombinant H. pylori sequences in E. coli The pET vector can be propagated in any E. coli K-12 strain e.g. HMS 174, HB101, SJM109, DH5, etc. for the purpose of cloning or plasmid preparation. Hosts for expression include E. coli strains containing a chromosomal copy of the gene for T7 RNA polymerase.
These hosts are lysogens of bacteriophage DE3, a lambda derivative that carries the lacI gene, the lacUV5 promoter and the gene for T7 RNA polymerase. T7 RNA polymerase is induced by addition of isopropyl-B-D-thiogalactoside (IPTG), and the T7 RNA polymerase transcribes any target plasmid, such as pET-28b, carrying a T7 promoter and a gene of interest. Strains used include: BL21(DE3) (Studier, Rosenberg, Dunn, and Dubendorff, J.W. (1990) Meth. Enzymol. 185, 60-89).
To express recombinant H. pylori sequences, 50 nanograms ofplasmid DNA isolated as described above was used to transform competent BL21(DE3) bacteria as described above (provided by Novagen as part of the pET expression system kit). The lacZ gene (beta-galactosidase) was expressed in the pET-System as described for the H. pylori recombinant constructions. Transformed cells were cultured in SOC medium for 1 hour, and the culture was then plated on LB plates containing 25 micrograms/ml kanamycin sulfate. The following day, bacterial colonies were pooled and grown in LB medium containing kanamycin sulfate (25 micrograms/ml) to an optical density at 600 nM of 0.5 to O.D. units, at which point, 1 millimolar IPTG was added to the culture for 3 hours to induce gene expression of the H. pylori recombinant DNA constructions.
After induction of gene expression with IPTG, bacteria were pelleted by centrifugation in a Sorvall RC-3B centrifuge at 3500 x g for 15 minutes at 4 0 C. Pellets were resuspended in 50 milliliters of cold 10 mM Tris-HCl, pH 8.0, 0.1 M NaCl and 0.1 mM EDTA (STE buffer). Cells were then centrifuged at 2000 x g for 20 min at 4 0 C. Wet pellets were weighed and frozen at -80 0 C until ready for protein purification.
III. Purification of recombinant proteins from E. coli Analytical Methods The concentrations of purified protein preparations were quantified spectrophotometrically using absorbance coefficients calculated from amino acid content (Perkins, S.J. 1986 Eur. J. Biochem. 157, 169-180). Protein concentrations were also measured by the method of Bradford, M.M. (1976) Anal. Biochem. 72, 248-254, and SLowry, Rosebrough, Farr, A.L. Randall, R.J. (1951) J. Biol. Chem. 193, pages 265-275, using bovine serum albumin as a standard.
SDS-polyacrylamide gels (12% or 4.0 to 25 acrylamide gradient gels) were :.purchased from BioRad (Hercules, CA, USA), and stained with Coomassie blue.
Molecular weight markers included rabbit skeletal muscle myosin (200 kDa), E. coli galactosidase (116 kDa), rabbit muscle phosphorylase B (97.4 kDa), bovine serum albumin (66.2 kDa), ovalbumin (45 kDa), bovine carbonic anhydrase (31 kDa), soybean trypsin inhibitor (21.5 kDa), egg white lysozyme (14.4 kDa) and bovine aprotinin (6.5 kDa).
1. Purification ofsoluble proteins All steps were carried out at 4 0 C. Frozen cells were thawed, resuspended in volumes of lysis buffer (20 mM Tris, pH 7.9, 0.5 M NaCI, 5 mM imidazole with glycerol. 0.1 2-mercaptoethanol. 200 pg/ ml lysozyme, 1 mM phenylmethylsulfonyl fluoride (PMSF), and 10 ug/ml each ofleupeptin, aprotinin, pepstatin, L-l-chloro-3-[4tosylamido]-7-amino-2-heptanone (TLCK), L-1-chloro-3-[4-tosylamido]-4-phenyl-2butanone (TPCK), and soybean trypsin inhibitor, and ruptured by several passages through a small volume microfluidizer (Model M- 110S, Microfluidics International Corporation, Newton, MA). The resultant homogenate was made 0.1 Brij 35, and centrifuged at 100,000 x g for 1 hour to yield a clear supernatant (crude extract).
Following filtration through a 0.8 j.m Supor filter (Gelman Sciences, FRG) the crude extract was loaded directly onto a Ni 2 nitrilotriacetate-agarose (NTA) with a milliliter bed volume (Hochuli, Dbeli. and Schacheer, A. (1987) J. Chromatography
I
411, 177-184) pre-equilibrated in lysis buffer containing 10 glycerol. 0.1 Brij 35 and 1 mM PMSF. The column was washed with 250 ml (50 bed volumes) of lysis buffer containing 10 glycerol, 0.1 Brij 35, and was eluted with sequential steps of lysis buffer containing 10 glycerol, 0.05 Brij 35, 1 mM PMSF, and 20. 100, 200, and 500 mM imidazole in succession. Fractions were monitored by absorbance at OD 2 8 0 nm, and peak fractions were analyzed by SDS-PAGE. Fractions containing the recombinant protein eluted at 100 mM imidazole.
Recombinant protein 14640637 (SEQ ID NO: 447) and proteins, beta-galactosidase (lacZ) and peptidyl-prolyl cis-trans isomerase (ppiB) Fractions containing the recombinant proteins from the Ni 2 +-NTA-agarose columns were pooled and then concentrated to approximately 5 ml by centrifugal filtration Amicon. MA), and loaded directly onto a 180-ml column (1.6 X 91 cm) of Sephacryl S-100 HR gel filtration medium equilibrated in Buffer A (10 mM Hepes, pH 150 mM NaCI, 0.1 mM EGTA) and run in Buffer A at 18 ml/h. Fractions containing the recombinant protein were identified by absorbance at 280 nm and analyzed by SDS-PAGE.
Fractions were pooled and concentrated by centrifugal filtration.
:Recombinant protein 7116626 (SEQ ID NO: 865) 20 Fractions containing the recombinant protein from the Ni 2 -NTA-agarose column S* were pooled and dialyzed overnight against 1 liter of dialysis buffer (10 mM MOPS, pH 50 mM NaC1, 0.1 mM EGTA, 0.02% Brij 35 and 1 mM PMSF). In the morning, a fine white precipitate was removed by centrifugation and the resulting supernatant was loaded onto an 8 ml (8 x 75 mm) MonoS high performance liquid chromatography column (Pharmacia Biotechnology, Inc., Piscataway, NJ, USA) equilibrated in buffer B (10 mM MOPS, pH 6.5, 0.1 mM EGTA) containing 50 mM NaC1. The column was washed with bed volumes of buffer B containing 50 mM NaC1, and developed with a 50-ml linear gradient of increasing NaCI (50 to 500 mM). Recombinant protein 7116626 (SEQ ID NO: 865) eluted as a sharp peak at 300 mM NaC1.
2. Purification of insoluble proteins from inclusion bodies The following steps were carried out at 4 0 C. Cell pellets were resuspended in lysis buffer with 10% glycerol 200 gg/ ml lysozyme, 5 mM EDTA, ImM PMSF and 0.1 mercaptoethanol. After passage through the cell disrupter, the resulting homogenate was made 0.2 deoxycholate, stirred 10 minutes, then centrifuged at 20,000 x g, for 30 min.
The pellets were washed with lysis buffer containing 10 glycerol, 10 mM EDTA, 1% Triton X-100. 1 mM PMSF and 0.1% -mercaptoethanol, followed by several washes with lysis buffer containing 1 M urea, 1 mM PMSF and 0.1 2-mercaptoethanol. The resulting -99white pellet was composed primarily of inclusion bodies, free of unbroken cells and membranous materials..
Recombinant proteins 26054702 (SEQ ID NO: 649), 16225006 (SEQ ID NO: 465), 30100332 (SEQ ID NO: 685), 4721061 (SEQ ID NO: 812) The following steps were carried out at room temperature. Purified inclusion bodies were dissolved in 20 ml 8.0 M urea in lysis buffer with 1 mM PMSF and 0.1 2mercaptoethanol, and incubated at room temperature for 1 hour. Materials that did not dissolve were removed by centrifugation. The clear supernatant was filtered, then loaded onto a Ni 2 -NTA agarose column pre-equilibrated in 8.0 M urea in Lysis Buffer. The column was washed with 250 ml (50 bed volumes) of lysis buffer containing 8 M urea, mM PMSF and 0.1 2-mercaptoethanol. and developed with sequential steps of lysis buffer containing 8M urea, 1 mM PMSF, 0.1 2-mercaptoethanol and 20, 100, 200, and 500 mM imidazole in succession. Fractions were monitored by absorbance at OD 2 8 0 nm, and peak fractions were analyzed by SDS-PAGE. Fractions containing the recombinant protein eluted at 100 mM imidazole.
Recombinant proteins 29479681 (SEQ ID NO: 677), 978477 (SEQ ID NO: 880). 26380318 (SEQ ID NO: 658) S' 20 The pellet containing the inclusion bodies was solubilized in buffer B containing 8 M urea, 1 mM PMSF and 0.1 2-mercaptoethanol, and incubated for 1 hour at room temperature. Insoluble materials were removed by centrifugation at 20,000 x g for 30 min, and the cleared supernatant was loaded onto a 15 ml 1.6 x 7.5 cm) SP-Sepharose column pre-equilibrated in buffer B, 6 M urea, 1 mM PMSF, 0.1 2-mercaptoethanol. After 25 washing the column with 10 bed volumes, the column was developed with a linear gradient from 0 to 500 mM NaCl.
999* Dialysis and concentration ofprotein samples S. Urea was removed slowly from the protein samples by dialysis against Trisbuffered saline (TBS; 10 mM Tris pH 8.0, 150 mM NaCI) containing 0.5 deoxycholate (DOC) with sequential reduction in urea concentration as follows; 6M, 4M, 3M, 2M, 1M, M and finally TBS without any urea. Each dialysis step was conducted for a minimum of 4 hours at room temperature.
After dialysis, samples were concentrated by pressure filtration using Amicon stirred-cells. Protein concentrations were measured using the methods of Perkins (1986 Eur. J. Biochem. 157, 169-180), Bradford ((1976) Anal. Biochem. 72, 248-254) and Lowry ((1951) J. Biol. Chem. 193, pages 265-275).
The recombinant proteins purified by the methods described above are summarized in Table 5 below.
~A~1 a 0** a 9* a. *q a a a a a *aa a..
a a.
a a TABLE Bacterial cell Final I lomolog Gene fraction used to Relative MW concentration J99 Sequence Identified symbol of purify recombinant Method of on SDS-PAGE of purified Composition Identifier by Blast Ilomolog proteins purification gel protein of buffer Outer Membrane Proteins 16225006 P28635 YEAC Inclusion bodies iiis-Trag 18 kDa 5 mg/mI B (SEQ ID NO: 465) 26054702 P15929 figH- Inclusion bodies Ilis-Tag 37 kDa 1.18 mg/mI B (SEQ ID NO: 649) as dry pellet 7116626 P26093 e(P4) Soluble fraction I Iis-Tag 29 kDa 0.8 mg/mI A (SEQ ID NO: 865) 1.85 mg/mI C 29479681 P13036 fecA Inclusions bodies SP-Sepharose 23 kDa 2.36 mg/n 1 B (SEQ I D NO: 677) 0.5 mg/nd B as dry pellet 14640637 P 16665 TPFI Soluble fraction His-Tag 17 kDa 2.4 mg/mI A (SEQ ID NO: 447) Ifiltration SI100O1 R 99* 9 999 9* 9 99 9. 9* 9 99 9 .9 9 9 *9 999 .9 9.
9 9 9. 9.
too 9 99 to 999 to.
TABLE 5 (continued) Periplasmic/Secreted Protein 3010032 P23847 dppA Inclusion bodies I Iis-Tag I I kDa 2.88 mg/mi B (SEQ ID NO: 685) 4721061 P36 175 GCP Inclusion bodies His-Tag 38 kDa 2.8 mg/mI B (SEQ ID NO: 812) Other Surface Proteins 4821082 P08089 M protein Inclusion bodies His-Tag 20 kDa 1. 16 mg/mI B (SEQ ID NO:820) 978477 L28919 -FB3P54 Inclusion bodies SP-Sepharose 44 kDa 2.56 mg/mI B (SEQ ID NO: 880) mg/mi B Inner Membrane Proteins 26380318 JP15933 M fG Inclusion bodies SP-Sepharose I I kDa 22 mg/mi B (SEQ ID NO: Control Proteins with His-Tag P00722 Inez Soluble fraction His-Tag 116 kDa 10 mg/mi A gel filtration S200 ppill Soluble fraction His-Tag j 2l kDa 4.4 mg/m I A filtration SINO Buffer compositions: A=l0 inM Hepes p11I 7.5, 150nm NaCl, 0. 1 mM EGTA B= 10 mM Tris pH 8.0,1I50 mM NaCI, 0.5 C= 10 mM MOPS p11 6.5, 300 m'M NaCI, 0. 1 EGTA___ -102- IV. Analysis of H. vlori proteins as Vaccine candidates To investigate the immunomodulatory effect of H. pylori proteins, a mouse/H.
pylori model was used. This model mimics the human H. pylori infection in many respects. The focus is on the effect of oral immunization in H. pylori infected animals in order to test the concept of therapeutic oral immunotherapy.
Animals Female SPF BALB/c mice were purchased from Bomholt Breeding center (Denmark). They were kept in ordinary makrolon cages with free supply of water and food.
The animals were 4-6 weeks old at arrival.
Infection After a minimum of one week of acclimatization, the animals were infected with a type 2 strain (VacA negative) ofH. pylori (strain 244. originally isolated from an ulcer patient). In our hands, this strain has earlier proven to be a good colonizer of the mouse stomach. The bacteria were grown overnight in Brucella broth supplemented with 10 fetal calf serum, at 37 0 C in a microaerophilic atmosphere (10% C0 2 5%02). The animals were given an oral dose of omeprazole (400 pmol/kg) and 3-5 h after this an oral inoculation of H. pylori in broth (approximately 108 cfu/animal). Positive take of the infection was checked in some animals 2-3 weeks after the inoculation.
Antigens Recombinant H. pylori antigens were chosen based on their association with externally exposed H. pylori cell membrane. These antigens were selected from the following groups: Outer Membrane Proteins; Periplastic/Secreted proteins; Outer Surface proteins; and Inner Membrane proteins. All recombinant proteins were too. constructed with a hexa-HIS tag for purification reasons and the non-Helicobacterpylori control protein (P-galactosidase from E. coli; LacZ), was constructed in the same way.
All antigens were given in a soluble form, i.e. dissolved in either a HEPES buffer or in a buffer containing 0.5% Deoxycholate
(DOC).
The antigens are listed in Table 6 below.
Table 6 Helicobacter pylori proteins Outer membrane Proteins SEQ ID NO:447 SEQ ID NO:677 SEQ ID NO:865 SEQ ID NO:812 SEQ ID NO:465 -103- Periplastic/Secreted proteins SEQ ID NO:685 Other cell envelope proteins SEQ ID NO:820 SEQ ID NO:880 Flagella-associated proteins SEQ ID NO:658 Control proteins P-galactosidase (LacZ) Immunizations Ten animals in each group were immunized 4 times over a 34 day period (day 1. and 35). Purified antigens in solution or suspension were given at a dose of 100 Hig/mouse. As an adjuvant. the animals were also given 10 gg/mouse of Cholera toxin (CT) with each immunization. Omeprazole (400 gmol/kg) was given orally to the animals 3-5 h 20 prior to immunization as a way of protecting the antigens from acid degradation. Infected control animals received HEPES buffer CT or DOC buffer CT. Animals were sacrificed 2-4 weeks after final immunization. A general outline of the study is shown in Table 7 below.
Table 7 Study outline, therapeutic immunization: Mice were all infected with H. pylori strain Ah244 at day 30. Proteins are listed by their SeqID a a.
a a a. a Mouse strain n=10 Substance Dose/mouse Dates for dosing 1.
2.
3.
4.
6.
7.
8.
9.
11.
12.
Controls, PBS Cholera toxin, 10 pg Protein 447, 100 pg CT 10 pg Protein 465, 100 pg CT 10 pg Protein 649, 100 pg CT 10 pg Protein 658. 100 pg CT 10 pg Protein 677, 100 pg CT 10 pg Protein 685, 100 pg CT 10 pg Protein 812, 100 pg CT 10 pg Protein 820, 100 pg CT 10 pg Protein 880. 100 pg CT 10 pg Protein 865. 100 pg CT 10 pg Balb/c Balb/c Balb/c Balb/c Balb/c Balb/c Balb/c Balb/c Balb/c Balb/c Balb/c Balb/c 0,3 ml 0,3 ml 0,3 ml 0,3 ml 0,3 ml 0,3 ml 0,3 ml 0,3 mi 0,3 ml 0,3 mi 0,3 ml 0,3 ml 0, 14,24,34 0, 14, 24, 34 0, 14,24,34 0, 14,24,34 0, 14, 24, 34 0, 14, 24, 34 0, 14, 24, 34 0, 14, 24, 34 0, 14, 24, 34 0, 14, 24, 34 0, 14, 24, 34 0. 14,24.34 -104- Analysis of infection Mucosal infection: The mice were sacrificed by CO 2 and cervical dislocation. The abdomen was opened and the stomach removed. After cutting the stomach along the greater curvature, it was rinsed in saline. The mucosa from the antrum and corpus of an area of 25mm 2 was scraped separately with a surgical scalpel. The mucosa scraping was suspended in Brucella broth and plated onto Blood Skirrow selective plates. The plates were incubated under microaerophilic conditions for 3-5 days and the number of colonies was counted. The identity ofH. pylori was ascertained by urease and catalase test and by direct microscopy or Gram staining.
The urease test was performed essentially as follows. The reagent, Urea Agar Base Concentrate, was purchased from DIFCO Laboratories. Detroit. MI (Catalog 0284-61-3).
Urea agar base concentrate was diluted 1:10 with water. 1 ml of if the diluted concentrate was mixed with 100-200 pl of actively growing H. pylori cells. Color change to magenta indicated that cells were urease positive.
The catalase test was performed essentially as follows. The reagent. NN,N',N'- Tetramethyl-p-Phenylenediamine, was purchased from Sigma, St. Louis, MO (Catalog T3134). A solution of the regent w/v in water) was prepared. H. pylori cells were swabbed onto Whatman filter paper and overlaid with the 1% solution. Color change to dark blue indicated that the cells were catalase positive.
20 Serum antibodies: From all mice serum was prepared from blood drawn by heart i puncture. Serum antibodies were identified by regular ELISA techniques, where the specific antigens of Helicobacter pylori were plated.
Mucosal antibodies: Gentle scrapings of a defined part of the corpus and of 4 cm of S: duodenum were performed in 50% of the mice in order to detect the presence of antibodies in the mucous. The antibody titers were determined by regular ELISA technique as for serum antibodies.
Statistical analysis: Wilcoxon-Mann-Whitney sign rank test was used for determination of significant effects of the antigens on Helicobacter pylori colonization.
S- P<0.05 was considered significant. Because the antrum is the major colonization site for Helicobacter most emphasis was put upon changes in the antral colonization.
Results Antibodies in sera: All antigens tested given together with CT gave rise to a measurable specific titer in serum. The highest responses were seen with SEQ ID NOs:865, 812, 658, 447, and 820 (see Figure 1).
Antibodies in mucus: In the mucus scrapings, specific antibodies against all antigens tested were seen. By far the strongest response was seen with SEQ ID NOs:685, followed by 447, 865, and 658 (see Figure 2).
-105- TheraDeutic immunization effects: All control animals (BALB/c mice) were well colonized with H. pylori (strain AH244) in both antrum and corpus of the stomach. Of the antigens tested 3 proteins (SEQ ID NOs: 812, 820, and 447) gave a good and significant reduction and/or eradication of the H. pylori infection. The degree of colonization of the antrum was lower following immunization with SEQ ID NOs: 880, 658, and 865 compared to control. The effect of SEQ ID NOs:465, 677, and 685 did not differ from control. The control protein lacZ, i.e.
the non-H. pylori protein, had no eradication effect and in fact had higher Helicobacter colonization compared to the HEPES CT control. All data are shown in Figures 3 and 4 for proteins dissolved in HEPES and DOC respectively. Data is shown as geometric mean values. n=8-10 Wilcoxon-Mann-Whitney sign rank test p<0.05; x/10 number of mice showing eradication of H. pylori over the total number of mice examined.
The data presented indicate that all of the H. pylori associated proteins included in this study, when used as oral immunogens in conjunction with the oral adjuvant CT, resulted in stimulation of an immune response as measured by specific serum and mucosal antibodies. A majority of the proteins led to a reduction, and in some cases complete clearance of the colonization of H. pylori in this animal model. It should be noted that the reduction or clearance was due to heterologous protection rather than homologous protection (the polypeptides were based on the H. pylori J99 strain sequence and used in the 20 therapeutic immunization studies against a different (AH244) challenge strain), indicating the vaccine potential against a wide variety ofH. pylori strains.
The highest colonization in the antrum was seen in animals treated with the non- Helicobacter protein LacZ, indicating that the effects seen with the Helicobacter pylori antigens were specific.
Taken together these data strongly support the use of these H. pylori proteins in a pharmaceutical formulation for the use in humans to treat and/or prevent H. pylori infections.
V. Sequence Variance Analysis of genes in Helicobacter pvlori strains Four genes were cloned and sequenced from several strains ofH. pylori to compare the DNA and deduced amino acid sequences. This information was used to determine the sequence variation between the H. pylori strain, J99, and other H. pylori strains isolated from human patients.
Preparation of Chromosomal DNA.
Cultures of H. pylori strains (as listed in Table 10) were grown in BLBB (1% Tryptone, 1% Peptamin 0.1% Glucose, 0.2% Yeast Extract 0.5% Sodium Chloride, Fetal Bovine Serum) to an OD 00 of 0.2. Cells were centrifuged in a Sorvall RC-3B at 3500 x g at 4 0 C for 15 minutes and the pellet resuspended in 0.95 mis of 10 mM Tris-HCl, -106- 0.1 mM EDTA Lysozyme was added to a final concentration of Img/ml along with, SDS to 1% and RNAse A TI to 0.5mg/ml and 5 units/ml respectively, and incubated at 37 0 C for one hour. Proteinase K was then added to a final concentration of 0.4mg/ml and the sample was incubated at 55 C for more than one hour. NaCl was added to the sample to a concentration of 0.65 M, mixed carefully, and 0.15 ml of 10% CTAB in 0.7M NaCL (final is 1% CTAB/70mM NaCL) was added followed by incubation at 650C for minutes. At this point, the samples were extracted with chloroform:isoamyl alcohol, extracted with phenol, and extracted again with chloroform:isoamyl alcohol. DNA was precipitated with either EtOH (1.5 x volumes) or isopropanol (0.6 x volumes) at -70 0 C for 1 Ominutes, washed in 70% EtOH and resuspended in TE.
PCR Amplification and cloning.
Genomic DNA prepared from twelve strains of Helicobacterpylori was used as the source of template DNA for PCR amplification reactions (Current Protocols in Molecular Biology, John Wiley and Sons, Inc.. F. Ausubel et al., editors, 1994). To amplify a DNA sequence containing an H. pylori ORF, genomic DNA (10 nanograms) was introduced into a reaction vial containing 2 mM MgCl 2 1 micromolar synthetic oligonucleotide primers (forward and reverse primers, see Table 8) complementary to and flanking a defined H.
S* pylori ORF, 0.2 mM of each deoxynucleotide triphosphate; dATP, dGTP, dCTP, dTTP and 20 0.5 units of heat stable DNA polymerase (Amplitaq, Roche Molecular Systems, Inc., Branchburg, NJ, USA) in a final volume of 20 microliters in duplicate reactions.
Table 8 Olionucleotide primers used for PCR amplification of H pylori DNA sequences.
a 99** 9. 9
S
Outer membrane Proteins Forward primer 5' to 3' Reverse Primer 5' to 3' SEQ ID NO:649 5'-TTAACCATGGTGAAAAGC (for strains AH4. GATA-3' (SEQ ID NO:1919) TTAG-3' (SEQ ID NO:1920) AH15, AH61, 5294, 5640, AH18, and AH244) SEQ ID NO:649 5'-TTAACCATGGTGAAAAGC (for strains AH5, GATA-3' (SEQ ID NO:1921) ATC-3' (SEQ ID NO:1922) 5155, 7958, AH24, and J99) SEQ ID NO:865 5'-ATATCCATGGTGAGTTTGA 5'-ATGAATTCAATTT IT ATTTT TGA-3' (SEQ ID NO: 1923) GCCA-3' (SEQ ID NO: 1924) SEQ ID NO:677 5'-AATTCCATGGCTATCCAAA TCCG-3' (SEQ ID NO:1925) GTATT-3' (SEQ ID NO:1926) SEQ ID NO:764 5'-GATACCATGGAATTTATGA AAAAG-3' (SEQ ID NO:1927) TATAC-3' (SEQ ID NO:1928) -107- The following thermal cycling conditions were used to obtain amplified DNA products for each ORF using a Perkin Elmer Cetus/ GeneAmp PCR System 9600 thermal cycler: Sequences (by SEQ ID NO:) 865 and 764; Denaturation at 94 0 C for 2 min, 2 cycles at 94 0 C for 15 sec, 30 0 C for 15 sec and 72 0 C for 1.5 min 23 cycles at 94 0 C for 15 sec, 55 0 C for 15 sec and 72 0 C for 1.5 min Reactions were concluded at 72 0 C for 6 minutes.
Sequence (by SEQ ID NO:) 649 for strains AH5. 5155, 7958, AH24,and J99; Denaturation at 94 0 C for 2 min, 2 cycles at 94 0 C for 15 sec, 30 0 C for 15 sec and 72 0 C for 1.5 min cycles at 94 0 C for 15 sec, 55 0 C for 15 sec and 72 0 C for 1.5 min Reaction was concluded at 72 0 C for 6 minutes.
Sequences (by SEQ ID NO:) 677 and 649 for strains AH4, AH15, AH61, 5294, 5640, AH18, and Hp244; Denaturation at 94 0 C for 2 min, 20 2 cycles at 940C for 15 sec, 30°C for 20 sec and 72°C for 2 min 25 cycles at 94C for 15 sec, 55°C for 20 sec and 72 0 C for 2 min Reactions were concluded at 72 0 C for 8 minutes.
Upon completion of thermal cycling reactions, each pair of samples were combined and used directly for cloning into the pCR cloning vector as described below.
Cloning ofH. pylori DNA sequences into the pCR TA cloning vector.
All amplified inserts were cloned into the pCR 2.1 (pCRII in the case ofH. pylori sequence 865) vector by the method described in the Original TA cloning kit (Invitrogen, San Diego, CA). Products of the ligation reaction were then used to transform the TOP1OF' (INVaF' in the case ofH. pylori sequence 865) strain ofE. coli as described below.
Transformation of competent bacteria with recombinant plasmids Competent bacteria, E coli strain TOP OF' or E. coli strain INVaF' were transformed with recombinant pCR expression plasmids carrying the cloned H. pylori sequences according to standard methods (Current Protocols in Molecular Biology, John Wiley and Sons, Inc., F. Ausubel et al., editors, 1994). Briefly, 2 microliters of micromolar BME was added to each vial of 50 microliters of competent cells.
I
-108- Subsequently, 2 microliters of ligation reaction was mixed with the competent cells and incubated on ice for 30 minutes. The cells and ligation mixture were then subjected to a "heat shock" at 42 0 C for 30 seconds, and were subsequently placed on ice for an additional 2 minutes, after which, samples were incubated in 0.45 milliliters SOC medium yeast extract, 2.0 tryptone, 10 mM NaCI, 2.5 mM KC1, 10 mM MgC12, 10 mM MgSO4 and 20, mM glucose) at 37 0 C with shaking for 1 hour. Samples were then spread on LB agar plates containing 25 microgram/ml kanamycin sulfate or 100 micrograms/ml ampicillan for growth overnight. Transformed colonies of TOP1OF' or INVaF' were then picked and analyzed to evaluate cloned inserts as described below.
Identification of recombinant PCR plasmids carrying H. pylori sequences Individual TOP OF' or INVaF' clones transformed with recombinant pCR-H.pylori ORFs were analyzed by PCR amplification of the cloned inserts using the same forward and reverse primers, specific for each H. pylori sequence, that were used in the original PCR amplification cloning reactions. Successful amplification verified the integration of the H. pylori sequences in the cloning vector (Current Protocols in Molecular Biology, John Wiley and Sons, Inc., F. Ausubel et al., editors, 1994).
Individual clones of recombinant pCR vectors carrying properly cloned H. pylori ORFs were picked for sequence analysis. Sequence analysis was performed on ABI Sequencers using standard protocols (Perkin Elmer) using vector-specific primers (as found 20 in PCRII or pCR2.1, Invitrogen, San Diego, CA) and sequencing primers specific to the ORF as listed in Table 9 below.
a -109- Table 9 Oligonucleotide primers, usqed for seqiuencing of H gvlori DNA sequences.
Outer Forward primers 5' to 3' Reverse Primers 5' to 3' membrane Proteins SEQ ID NO:649 5'-CCCTTCAT1TTAGAAATCG-.' 5'-CTITGGGTAAAAACGCATC..3' (SEQ ID NO: 1929) (SEQ ID NO: 1936) 3'(SEQ ID NO: 1930) 3'(SEQ ID NO: 1937) 5'-ATCAAGTTGCCTATGCTGA-.3' 3' (SEQ I D NO: 193 1) (SEQ ID NO: 1938) AGT-3' (SEQ ID NO: 1932) TCG-3' (SEQ ID NO: 1933) AGT-3' (SEQ ID NO: 1934) GGT-3' (SEQ ID NO: 193 SEQ ID NQ:865 5'-T-TGAACACTITGATTATG CGG-3' (SEQ ID NO: 1939) GTC-3' (SEQ ID NO: 194 1) 5'-GGATTATGCGATTI IIAC AAG-3' (SEQ ID NO: 1940) TTFC-3' (SEQ ID NO: 1942) SEQ ID NO:677 5*-CTTATGGGGGTATTGTCA..3' 5'-AGGTTGTTGCCTAAAGACT..3' (SEQ ID NO: 1943) (SEQ ID NO: 1945) 5'-AGCATGTGGGTATCCAGC..3' 5'-CTGCCTCCACCTTTGATC-.3' ID NO: 1944) (SEQ ID NO: 1946) SEQ ID NQ:764 5'-ACGAATATCAATTGGCACT..3' 5'-CTTGCTTGTCATATCTAGC..3' (SEQ ID NO: 1947) (SEQ ID NO: 1949) 5'-ACTTGGAAAAGCTCTGGA..3' 5'-GT1TGAAGTGTTGGTGCTA..3' ID NO: 1948) (SEQ ID NO: 1950)
)-'-GCCCATAATCAAAAAGCC
TAG-3' (SEQ ID NO: 195 1) CAT-3' (SEQ ID NO: 1953) 5'-TGGAAAGAGCAAATCAUTG AAG-3' (SEQ ID NO: 1952) TTGTC-3' (SEQ ID NO: 1954) Vector Primers 5'-GTAAAACGACGGCCAG-3- 5'-CAGGAAACAGCTATGAC-3' (SEQ ID NO: 1955) (SEQ ID NO: 1956) Results To establish the PCR error rate in these experiments, five individual clones of SEQ ID NO:649, prepared from five separate PCR reaction mixtures from H. pylori strain J99, were sequenced over a total length of 897 nucleotides for a cumulative total of 4485 bases of DNA sequence. DNA sequence for the five clones was compared to the DNA sequence of SEQ ID NO:649 obtained previously by a different method, random shotgun cloning and sequencing. The PCR error rate for the experiments described herein was determined to be 2 base changes out of 4485 bases, which is equivalent to an estimated error rate of less than or equal to 0.04%.
-110- DNA sequence analysis was performed on four different open reading frames identified as genes and amplified by PCR methods from a dozen different strains of the bacterium Helicobacterpylori. The deduced amino acid sequences of three of the four open reading frames that were selected for this study showed statistically significant BLAST homology to defined proteins present in other bacterial species. Those ORFs included: SEQ ID NO:649, homologous to the val A B genes encoding an ABC transporter in F. novicida; SEQ ID NO:865, homologous to lipoprotein e (P4) present in the outer membrane of H. influenzae; SEQ ID NO:677, homologous to fecA, an outer membrane receptor in iron (III) dicitrate transport in E. coli. SEQ ID NO:764 was identified as an unknown open reading frame, because it showed low homology with sequences in the public databases.
To assess the extent of conservation or variance in the ORFs across various strains of H. pylori, changes in DNA sequence and the deduced protein sequence were compared to the DNA and deduced protein sequences found in the J99 strain ofH. pylori (see Table 10 below). Results are presented as percent identity to the J99 strain of H. pylori sequenced by random shotgun cloning. To control for any variations in the J99 sequence each of the four open reading frames were cloned and sequenced again from the J99 bacterial strain and that sequence information was compared to the sequence information that had been o collected from inserts cloned by random shotgun sequencing of the J99 strain. The data demonstrate that there is variation in the DNA sequence ranging from as little as 0.12 difference (SEQ ID NO:764, J99 strain) to approximately 7% change (SEQ ID NO:649, strain AH5). The deduced protein sequences show either no variation (SEQ ID NO:764, strains AH18 and AH24) or up to as much as 7.66% amino acid changes (SEQ ID NO:649, Strain -111- Table Multiple Strain DNA Sequence analysis of H. pylori Vaccine Candidates J99 Sea. ID 649 649 865 865 677 677 764 764 Length of 248 a.a. 746 nt. 232 a.a. 696 nt. 182 a.a. 548 nt. 273 a.a. 819 nt.
Region Sequenced: Strain Tested AA Nuc. AA Nuc. AA Nuc. AA Nuc.
identity identity identity identity identity identity identity identity J99 100.00% 100.00% 100.00% 100.00% 100.00% 100.00% 99.63% 99.88% AH244 95.16% 95.04% n.d. n.d. 99.09% 96.71% 98.90% 96.45% AH4 95.97% 95.98% 97.84% 95.83% n.d. n.d. 97.80% 95.73% 92.34% 93.03% 98.28% 96.12% 98.91% 96.90% 98.53% 95.73% 95.16% 94.91% 97.41% 95.98% 99.82% 97.99% 99.63% 96.09% AH61 n.d. n.d. 97.84% 95.98% 99.27% 97.44% n.d. n.d.
5155 n.d. n.d. n.d. n.d. 99.45% 97.08% 98.53% 95.60% 5294 94.35% 94.37% 98.28% 95.40% 99.64% 97.26% 97.07% 95.48% 7958 94.35% 94.10% 97.84% 95.40% n.d. n.d. 99.63% 96.46% 5640 95.16% 94.37% 97.41% 95.69% 99.09% 97.63% 98.53% 95.48% AH18 n.d. n.d. 98.71% 95.69% 99.64% 97.44% 100.00% 95.97% AH24 94.75% 95.04% 97.84% 95.40% 99.27% 96.71% 100.00% 96.46% n.d. not done 5 VI. Experimental Knock-Out Protocol for the Determination of Essential H. pylori Genes S as Potential Therapeutic Targets Therapeutic targets are chosen from genes whose protein products appear to play key roles in essential cell pathways such as cell envelope synthesis, DNA synthesis, transcription, translation, regulation and colonization/virulence.
The protocol for the deletion of portions of H. pylori genes/ORFs and the insertional mutagenesis of a kanamycin-resistance cassette in order to identify genes which are essential to the cell is modified from previously published methods (Labigne-Roussel et al., 1988, J. Bacteriology 170, pp. 1704-1708; Cover et al.,1994, J. Biological Chemistry 269, pp. 10566-10573; Reyrat et al., 1995, Proc. Natl. Acad. Sci. 92, pp 8768-8772). The result is a gene "knock-out." Identification and Cloning ofH. pylori Gene Sequences The sequences of the genes or ORFs (open reading frames) selected as knock-out targets are identified from the H. pylori genomic sequence and used to design primers to specifically amplify the genes/ORFs. All synthetic oligonucleotide primers are designed with the aid of the OLIGO program (National Biosciences, Inc., Plymouth, MN 55447, USA), and can be purchased from Gibco/BRL Life Technologies (Gaithersburg, MD, USA). If the ORF is smaller than 800 to 1000 base pairs, flanking primers are chosen outside of the open reading frame.
-112- Genomic DNA prepared from the Helicobacter pylori HpJ99 strain (ATCC 55679) is used as the source of template DNA for amplification of the ORFs by PCR (polymerase chain reaction) (Current Protocols in Molecular Biology, John Wiley and Sons, Inc., F.
Ausubel et al., editors, 1994). For the preparation of genomic DNA from H. pylori, see Example I. PCR amplification is carried out by introducing 10 nanograms of genomic HpJ99 DNA into a reaction vial containing 10 mM Tris pH 8.3, 50 mM KC1. 2 mM MgCl 2 2 microMolar synthetic oligonucleotide primers (forward=F and reverse=Rl), 0.2 mM of each deoxynucleotide triphosphate (dATP,dGTP, dCTP, dTTP), and 1.25 units of heat stable DNA polymerase (Amplitaq, Roche Molecular Systems, Inc., Branchburg, NJ, USA) in a final volume of40 microliters. The PCR is carried out with Perkin Elmer Cetus/GeneAmp PCR System 9600 thermal cyclers.
Upon completion of thermal cycling reactions, each sample of amplified DNA is visualized on a 2% TAE agarose gel stained with Ethidium Bromide (Current Protocols in Molecular Biology, John Wiley and Sons, Inc., F. Ausubel et al., editors, 1994) to determine that a single product of the expected size had resulted from the reaction.
Amplified DNA is then washed and purified using the Qiaquick Spin PCR purification kit (Qiagen, Gaithersburg, MD, USA).
PCR products are cloned into the pT7Blue T-Vector (catalog#69820-1, Novagen, Inc., Madison, WI, USA) using the TA cloning strategy (Current Protocols in Molecular 20 Biology, John Wiley and Sons, Inc., F. Ausubel et al., editors, 1994). The ligation of the PCR product into the vector is accomplished by mixing a 6 fold molar excess of the PCR product, 10 ng of pT7Blue-T vector (Novagen), 1 microliter of T4 DNA Ligase Buffer (New England Biolabs, Beverly, MA, USA), and 200 units of T4 DNA Ligase (New England Biolabs) into a final reaction volume of 10 microliters. Ligation is allowed to proceed for 16 hours at 16 0
C.
Ligation products are electroporated (Current Protocols in Molecular Biology, John Wiley and Sons, Inc., F. Ausubel et al., editors, 1994) into electroporation-competent XL-1 Blue or DH5-a E.coli cells (Clontech Lab., Inc. Palo Alto, CA, USA). Briefly, 1 microliter of ligation reaction is mixed with 40 microliters of electrocompetent cells and subjected to a high voltage pulse (25 microFarads, 2.5 kV, 200 ohms) after which the samples are incubated in 0.45 ml SOC medium yeast extract, 2% tryptone, 10 mM NaCI, 2.5 mM KCI, 10 mM MgCl 2 10 mM MgSO 4 and 20 mM glucose) at 37 0 C with shaking for 1 hour.
Samples are then spread onto LB (10 g/l bacto tryptone, 5 g/1 bacto yeast extract, 10 g/l sodium chloride) plates containing 100 microgram/ml of Ampicillin, 0.3% X-gal, and 100 microgram/ml IPTG. These plates are incubated overnight at 37 0 C. Ampicillin-resistant colonies with white color are selected, grown in 5 ml of liquid LB containing 100 microgram/ml of Ampicillin. and plasmid DNA is isolated using the Qiagen miniprep protocol (Qiagen, Gaithersburg, MD, USA).
-113- To verify that the correct H.pylori DNA inserts had been cloned, these pT7Blue plasmid DNAs are used as templates for PCR amplification of the cloned inserts, using the same forward and reverse primers used for the initial amplification of the J99 H.pylori sequence. Recognition of the primers and a PCR product of the correct size as visualized on a 2% TAE, ethidium bromide stained agarose gel are confirmation that the correct inserts had been cloned. Two to six such verified clones are obtained for each knock-out target, and frozen at -70 0 C for storage. To minimize errors due to PCR, plasmid DNA from these verified clones are pooled, and used in subsequent cloning steps.
The sequences of the genes/ORFs are again used to design a second pair of primers which flank the region ofH. pylori DNA to be either interrupted or deleted (up to 250 basepairs) within the ORFs but are oriented away from each other. The pool of circular plasmid DNAs of the previously isolated clones are used as templates for this round of PCR. Since the orientation of amplification of this pair of deletion primers is away from each other, the portion of the ORF between the primers is not included in the resultant PCR product. The PCR product is a linear piece of DNA with H. pylori DNA at each end and the pT7Blue vector backbone between them which, in essence, resultes in the deletion of a portion of the ORFs. The PCR product is visualized on a 1% TAE, ethidium bromide stained agarose gel to confirm that only a single product of the correct size has been amplified.
20 A Kanamycin-resistance cassette (Labigne-Roussel et al., 1988 J. Bacteriology 170, 1704-1708) is ligated to this PCR product by the TA cloning method used previously (Current Protocols in Molecular Biology, John Wiley and Sons, Inc., F. Ausubel et al., editors, 1994). The Kanamycin cassette containing a Campylobacter kanamycin resistance gene is obtained by carrying out an EcoRI digestion of the recombinant plasmid pCTB8:kan (Cover et al.,1994, J. Biological Chemistry 269, pp. 10566-10573). The proper fragment (1.4 kb) is isolated on a 1% TAE gel, and isolated using the QIAquick gel extraction kit (Qiagen, Gaithersburg, MD, USA). The fragment is end repaired using the Klenow fill-in protocol, which involved mixing 4ug of the DNA fragment, 1 microliter of dATPdGTP, dCTP, dTTP at 0.5 mM, 2 microliter of Klenow Buffer (New England Biolabs) and 5 units of Klenow DNA Polymerase I Large (Klenow) Fragment (New England Biolabs) into a 20 microliter reaction, incubating at 30 0 C for 15 min, and inactivating the enzyme-by heating to 75 0 C for 10 minutes. This blunt-ended Kanamycin cassette is then purified through a Qiaquick column (Qiagen, Gaithersburg, MD, USA) to eliminate nucleotides. The overhang is then generated by mixing 5 micrograms of the blunt-ended kanamycin cassette, 10 mM Tris pH 8.3, 50 mM KC1, 2 mM MgCl 2 5 units of DNA Polymerase (Amplitaq, Roche Molecular Systems, Inc., Branchburg, NJ, USA), microliters of 5 mM dTTP, in a 100 microliter reaction and incubating the reaction for 2 hours at 37 0 C. The "Kan-T" cassette is purified using a QIAquick column (Qiagen, Gaithersburg, MD, USA). The PCR product of the deletion primers (F2 and R2) is ligated -114to the Kan-T cassette by mixing 10 to 25 ng of deletion primer PCR product. 50 75 ng Kan-T cassette DNA, 1 microliter 1Ox T4 DNA Ligase reaction mixture, 0.5 microliter T4 DNA Ligase (New England Biolabs, Beverly, MA, USA) in a 10 microliter reaction and incubating for 16 hours at 16 0
C.
The ligation products are transformed into XL-1 Blue or DH5-a E.coli cells by electroporation as described previously. After recovery in SOC, cells are plated onto LB plates containing 100 microgram/ml Ampicillin and grown overnight at 37 0 C. These plates are then replica plated onto plates containing 25 microgram/ml Kanamycin and allowed to grow overnight. Resultant colonies have both the Ampicillin resistance gene present in the pT7Blue vector, and the newly introduced Kanamycin resistance gene. Colonies are picked into LB containing 25 microgram/ml Kanamycin and plasmid DNA is isolated from the cultured cells using the Qiagen miniprep protocol (Qiagen, Gaithersburg, MD, USA).
Several tests by PCR amplification are conducted on these plasmids to verify that the Kanamycin is inserted in the H. pylori gene/ORF, and to determine the orientation of the insertion of the Kanamycin-resistance gene relative to the H. pylori gene/ORF. To verify that the Kanamycin cassette is inserted into the H. pylori sequence, the plasmid DNAs are used as templates for PCR amplification with the set of primers originally used to clone the H. pylori gene/ORFs. The correct PCR product is the size of the deleted gene/ORF but increased in size by the addition of a 1.4 kilobase Kanamycin cassette. To 20 avoid potential polar effects of the kanamycin resistance cassette on H. pylori gene S* expression, the orientation of the Kanamycin resistance gene with respect to the knock-out gene/ORF is determined and both orientations are eventually used in H. pylori transformations (see below). To determine the orientation of insertion of the kanamycin resistance gene, primers are designed from the-ends of the kanamycin resistance gene ("Kan-1" 5'-ATCTTACCTATCACCTCAAAT-3', and "Kan-2" AGACAGCAACATCTTTGTGAA-3'). By using each of the cloning primers in conjunction with each of the Kan primers (4 combinations of primers), the orientation of the Kanamycin cassette relative to the H.pylori sequence is determined. Positive clones S:S are classified as either in the orientation (the same direction of transcription is present for both the H. pylori gene and the Kanamycin resistance gene), or in the orientation (the direction of transcription for the H.pylori gene is opposite to that of the Kanamycin resistance gene). Clones which share the same orientation (A or B) are pooled for subsequent experiments and independently transformed into H. pylori.
Transformation ofPlasmid DNA into H. pylori cells Two strains of H. pylori are used for transformation: ATCC 55679, the clinical isolate which provided the DNA from which the H. pylori sequence database is obtained, and AH244, an isolate which had been passaged in, and has the ability to colonize the mouse stomach. Cells for transformation are grown at 37 0 C, 10% CO2, 100% humidity, -115either on Sheep-Blood agar plates or in Brucella Broth liquid. Cells are grown to exponential phase, and examined microscopically to determine that the cells are "healthy" (actively moving cells) and not contaminated. If grown on plates, cells are harvested by scraping cells from the plate with a sterile loop, suspended in 1 ml of Brucella Broth, spun down (1 minute, top speed in eppendorf microfuge) and resuspended in 200 microliters Brucella Broth. If grown in Brucella Broth liquid, cells are centrifuged (15 minutes at 3000 rpm in a Beckman TJ6 centrifuge) and the cell pellet resuspended in 200 microliters of Brucella broth. An aliquot of cells is taken to determine the optical density at 600 nm, in order to calculate the concentration of cells. An aliquot (1 to 5 OD 6 00 oo units/25 microliter) of the resuspended cells is placed onto a prewarmed Sheep-Blood agar plate, and the plate is further incubated at 37 0 C, 6% CO2, 100% humidity for 4 hours. After this incubation, microliters of plasmid DNA (100 micrograms per microliter) is spotted onto these cells.
A positive control (plasmid DNA with the ribonuclease H gene disrupted by kanamycin resistance gene) and a negative control (no plasmid DNA) are done in parallel. The plates are returned to 37 0 C, 6% CO 2 for an additional 4 hours of incubation. Cells are then spread onto that plate using a swab wetted in Brucella broth, and grown for 20 hours at 37 0 C, 6% CO 2 Cells are then transferred to a Sheep-Blood agar plate containing micrograms/ml Kanamycin, and allowed to grow for 3 to 5 days at 37 0 C, 6% CO 2 100% humidity. If colonies appear, they are picked and regrown as patches on a fresh Sheep- 20 Blood agar plate containing 25 micrograms/ml Kanamycin.
Three sets of PCR tests are done to verify that the colonies of transformants have arisen from homologous recombination at the proper chromosomal location. The template for PCR (DNA from the colony) is obtained by a rapid boiling DNA preparation method as follows. An aliquot of the colony (stab of the colony with a toothpick) is introduced into 100 microliters of 1% Triton X-100, 20 mM Tris, pH 8.5, and boiled for 6 minutes. An equal volume of phenol chloroform is added and vortexed. The mixture is microfuged for 5 minutes and the supernatant is used as DNA template for PCR with combinations of the following primers to verify homologous recombination at the proper "chromosomal location.
TEST 1. PCR with cloning primers originally used to amplify the gene/ORF. A positive result of homologous recombination at the correct chromosomal location should show a single PCR product whose size is expected to be the size of the deleted gene/ORF but increased in size by the addition of a 1.4 kilobase Kanamycin cassette. A PCR product of just the size of the gene/ORF is proof that the gene had not been knocked out and that the transformant is not the result of homologous recombination at the correct chromosome location.
TEST 2. PCR with F3 (primer designed from sequences upstream of the gene/ORF and not present on the plasmid), and either primer Kan-1 or Kan-2 (primers designed from the ends of the kanamycin resistance gene), depending on whether the plasmid DNA used -116was of or orientation. Homologous recombination at the correct chromosomal location will result in a single PCR product of the expected size from the location of F3 to the insertion site ofkanamycin resistance gene). No PCR product or PCR product(s) of incorrect size(s) will prove that the plasmid had not integrated at the correct site and that the gene had not been knocked out.
TEST 3. PCR with R3 (primer designed from sequences downstream of the gene/ORF and not present on the plasmid) and either primer Kan-1 or Kan-2, depending on whether the plasmid DNA used was of or orientation. Homologous recombination at the correct chromosomal location will result in a single PCR product of the expected size from the insertion site of kanamycin resistance gene to the downstream location of R3). Again, no PCR product or PCR product(s) of incorrect size(s) will prove that the plasmid had not integrated at the correct site and that the gene had not been knocked out.
Transformants showing positive results for all three tests above indicate that the gene is not essential for survival in vitro.
A negative result in any of the three above tests for each transformant indicates that the gene had not been disrupted, and that the gene is essential for survival in vitro.
In the event that no colonies result from two independent transformations while the positive control with the disrupted ribonuclease H plasmid DNA produces transformants, the plasmid DNA is further analyzed by PCR on DNA from transformant populations prior 20 to plating for colony formation. This will verify that the plasmid can enter the cells and undergo homologous recombination at the correct site. Briefly, plasmid DNA is incubated according to the transformation protocol described above. DNA is extracted from the H.
pylori cells immediately after incubation with the plasmid DNAs and the DNA is used as template for the above TEST 2 and TEST 3. Positive results in TEST 2 and TEST 3 would verify that the plasmid DNA could enter the cells and undergo homologous recombination at the correct chromosomal location. If TEST 2 and TEST 3 are positive, then failure to obtain viable transformants indicates that the gene is essential, and cells suffering a disruption in that gene are incapable of colony formation VII. High-throughput drug screen assay Cloning, expression and protein purification Cloning, transformation, expression and purification of the H. pylori target gene and its protein product,e.g., an H. pylori enzyme, to be used in a high-throughput drug screen assay, is carried out essentially as described in Examples II and III above. Development and application of a screening assay for a particular H. pylori gene product, peptidyl-propyl cis-trans isomerase, is described below as a specific example.
-117- Enzymatic Assay The assay is essentially as described by Fisher (Fischer, et.al. (1984) Biomed.
Biochim. Acta 43:1101-1111). The assay measures the cis-trans isomerization of the Ala- Pro bond in the test peptide N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide (Sigma S-7388, lot 84H5805). The assay is coupled with a-chymotrypsin, where the ability of the protease to cleave the test peptide occurs only when the Ala-Pro bond is in trans. The conversion of the test peptide to the trans isomer in the assay is followed at 390 nm on a Beckman Model DU-650 spectophotometer. The data are collected every second with an average scanning of time of 0.5 second. Assays are carried out in 35 mM Hepes, pH 8.0, in a final volume of 400 ul, with 10 gM a-chymotrypsin (type 1-5 from bovine Pancreas, Sigma C-7762, lot 23H7020) and 10 nM PPIase. To initiate the reaction, 10 Cl of the substrate 2 mM N-Succinyl-Ala-Ala-Pro-Phe-p-nitroanilide in DMSO) is added to 390 p.1 of reaction mixture at room temperature.
Enzymatic assay in crude bacterial extract.
A 50 ml culture of Helicobacterpylori (strain J99) in Brucella broth is harvested at oo** •mid-log phase (OD 600 nm 1) and resuspended in lysis buffer with the following protease inhibitors: 1 mM PMSF, and 10 pg/ml of each of aprotinin, leupeptin, pepstatine, TLCK, TPCK, and soybean trypsin inhibitor. The suspension is subjected to 3 cycles of freeze- 20 thaw (15 minutes at -70 C, then 30 minutes at room temperature), followed by sonication (three 20 second bursts). The lysate is centrifuged (12,000 g x 30 minutes) and the supernatant is assayed for enzymatic activity as described above.
Many H. pylori enzymes can be expressed at high levels and in an active form in E.
coli. Such high yields of purified proteins provide for the design of various high throughput drug screening assays.
EQUIVALENTS
Those skilled in the art will recognize, or be able to ascertain using no more than routine experimentation, many equivalents to the specific embodiments and methods described herein. Such equivalents are intended to be encompassed by the scope of the following claims.
I
SEQUENCE LISTING GENERAL INFORMATION:
APPLICANT:
NAME: Astra Aktiebolag STREET: S-151 CITY: Sodertalje
STATE:
COUNTRY: Sweden POSTAL CODE (ZIP): (ii) TITLE OF INVENTION: NUCLEIC ACID AND AMINO ACID SEQUENCES RELATING TO HELICOBACTER PYLORI FOR DIAGNOSTICS AND THERAPEUTICS (iii) NUMBER OF SEQUENCES: 1956 (iv) COMPUTER READABLE FORM: MEDIUM TYPE: 8-mm cartridge tape COMPUTER: SPARC station LX OPERATING SYSTEM: SunOS Release 4.1.3 SOFTWARE: tar CURRENT APPLICATION DATA: APPLICATION NUMBER: PCT/US96/09122 FILING DATE: June 6, 1996 (vi) PRIOR APPLICATION DATA: i APPLICATION NUMBER: US 08/630,405 FILING DATE: 01-APR-1996 (vii) PRIOR APPLICATION DATA: APPLICATION NUMBER: US 08/561,469 FILING DATE: 17-NOV-1995 (viii) PRIOR APPLICATION DATA: APPLICATION NUMBER: US 08/487,032 FILING DATE: Z7-JUNE-1995 (ix) CORRESPONDENCE ADDRESS: ADDRESSEE: LAHIVE COCKFIELD STREET: 60 State Street, Suite 510 CITY: Boston STATE: Massacnusetts COUNTRY: USA ZIP: 02109-:E75 ATTORNEY/AGENT :::F:c.MAT:ON: NAME: Mandra;uras. Amy E.
REGISTRATL:: 36,207 REFERENCE,/2=:i:E. J:MBER: GTN-001C5PC (xi) TELECOMMUNICATI:: :::F:RMATION: TELEPHONE: (617)227-7400 TELEFAX: (617)227-5941 INFORMATION FOR SEQ ID NO:l: SEQUENCE CHARACTERISTICS: LENGTH: 1S27 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1527 (Xi) SEQUENCE DESCRIPTION: SEQ ID NO:1 *o 4 0 0
ATGTGTTCTC
A.ATATCATCA
AATAAAGACC
AATTATGTCA
GGGATATTAT
TGTATTCTCA
GACCAAAAAG
GACAACCTAT
TTIGTATCTCA
GATGTTTrAA
TCAAAATTAA
CAACAACTAC
GAAAATTATT
GAAGAAAIAAA
CTTA'TrTTG
AAGAATGCTA
TCAGGTCAAA
CATCAACAAA
GATAATCTTT
CTAAAATCTT
GGAGCGCAAT
AGAGCCTTTT
CCCATI'ATGG
TTAATTATTA
CAAGGCAAAC
TGCGAATTGT
AGGAAA77111
CTCAGCTTGC
ATACTATCAA
GTAATCT11rT
TTTCCATTAG
TTTCCAACCA
AAAGCATGCA
TATTTAACTT
ATAATTTrGT
TCACCACTCT
F1'GGTGTGGG AAGATrATC TCTGTATTr
TCCATAGCAT
AAAACTT'rAA
GCGGAAAAAG
'ITATCATTAA
TGAGTGCCAT
TTATGCAAAA
TTGATGAGAA
ATAATGGGGT
TAAAACCAAG
AAAAAGAGITT
CACACCGCAT
TAATAGAACA
TITI'GAAACA
ATCAAGCT1'G
TAATAAACTC
GCTTAACACT
TTCAATCTA,
TATTTATCTA
TATAGCAAAA
AAATTACTTA
CATGCTAAAT
GAAAGTAGCC
AAGTATTGCA
AGCAATTGCT
ATTT~TATGGA
AGAITACAAA
TACATTrGAA TCTCTCTTT1A
CACGCTGATT
TAACAAATAC
ATTTCAAGAT
CAATATCACT
TTTCAAAAT
AGATTI'ITCT
TAATTGCATrr
TTTAGATT
GAATAGTGTC
GGGCAACTTT
ACAATAC
CAAACCATTA
ACACAAGTTA
ATCCATAACG
CAACGCATTA
CCCTTTATAA
AAACATAGTG
TACTCTGGAC
ITTCACCATA
CAAAAAAACT
CTATTITTTTC
GGGTATATCC
AAGTGGTT'TT
ATACCGAAAC
AATAT1'AGTT
CACTCTAATA
AATTTATTAT
CCATTACAAG
'11-1 CTCTIT
AAAGAGCAAT
TGTCTTAATG
TTIAGGTCAAA
GTTTTAGATG
ATFTTAAAA
AAGCAAGCTA
GAAACCCrI'A
TTGCCGAACA
AAAATCTAAA
GACTGCACAT
TAGGGCT'AT
TGATTTTTGC
CTTCCATAGA
TAGATAACCA
AATTTATTGA
TAATATrI'AC TAATGG TTr
AAGCATTTAG
ITGCTATCAA
CAGAAACACA
TCTCTTATCC
AAATTTATGC
TAGG'rITITA
ACTTGGAACT
ATGCTGGGTA
TGAAGCAAAA
ATTGCAACAA
AGCAACGCAT
AGCCAAGCAG
AATCGCAATC
ATGAAA ETAT
TGAAAAAACA
ATTTTCTATA
TTTTTTTGAG
CCGCCCCCTA
CAGTCTGTTT
AACAGTGCCT
TAAACTTCAA
AAAGAACAAG
AACAAAAGAA
CATATATGCT
TATTATCCTT
CTCTACCCAA
TAAATACTT
AATCAAArrA
TAATTCAAAJA
ATTAGTCGGC
TACCCCAAAT
AAATAGCTAC
TAGCATTGAT
AAGAGAAATA
CACACTATT
AGCTACCATG
CGCCATCGAT
TAAGATGGCT
CGTGITAGAT
GGGATATT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1527 INFORMATION FOR SEQ ID NO:2: SEQUENCE CHARACTERISTICS: LENGTH: 399 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO 120 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .399 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2
ATGGAGCGCA
AAAGGTATTC
ACAGGTI'TAG
ACGGTAGTTG
GGAGTGATCG
GCCATTCCAG
TATGTGCAGA
AGACGCTCCA
TAATGAATTG
TGGTGTTGAG
AAATTITAGA
CACCCATTAT
CCTATTCT
TGCAAGTGGA
GAGCATTITA
TTGCAGGSCT
CATTATCTCT
AGCGTTTAAC
TTCTAAGGCG
TTACTTGATC
TATTI'TGTCT
TGTTTAATAA
TGGAAACACC
TCTACAGCCC
AATI'TGGGCG
CTTATCGCCA
TTAAAGCGCA
TCTAAAAAA
AAAAAGAAAT
AGGTTC'FrAA
CCTTTATTGG
CGTTAGGTCA
CCGCTGCAGG
AGGTGTATGA
GATGAGACCA
GCAAAGCACG
TTTGTTTGGG
AGCTTCT'T
GATTFI'AGCA
TTTATCGGTT
INFORMATION FOR SEQ ID NO:3: SEQUENCE CHARACTERISTICS: LENGTH: 474 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .474 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:3
ATGCATGAAC
GAACTCAAAC
GAGGAACAAT
GATTCTCTAG
AATATGGATA
C'FICTATIGA
GTGGGGGTAG
AGAAAAGAAG
GCATTGAAAG
AAAGAAAGAC
TCCGTGGAAG
CGATTATAAA
GCGGCATI'GA
CGCCTGTAGT
GTAAATCAAT
TGGATAAGAA
AGGTATTRGA
AAAATTGATT
TGTAGGAAAA
ACGCATCAAT
TACAATAGGC
AGGTGAGTTT
ATGGAGFFI'T
T'FrACATCAA
AATA.ATGAAT
GAAGACATAG
AATATTGAAC
AACCTTGGTC
'IWATTTAGTT
GCGTTAATTG
TTTGATTCAG
ATTTGCGAAA.
GTAAAGAAAT
AACGGCGGTT
AACTrGAAGA
TTAATCCTAA.
CAATAGGAGG
CAGGAGTGGG
A'FTATAAAAA
ATTGTGCAG
T I TGGCAAT
CAAAGAATGC
AAGAGTI'AAA
TTCTAA~T
ITTGGTGTTG
TTTAGCATITA
ATCCCAACAA
GATG
INFORMATION FOR SEQID NO:4: SEQUENCE CHARACTERISTICS: LENGTH: 336 base pairs TYPE: nucleic acid STRANDEDNESS: double.
TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .336 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:4 ATGCCTGGCG TGTATCAAAT GACTATAGAG CCTCT TT AA AAGAATGCGA. AGAATTAGTG GGTITAGGCA TAAAAGCCGT TT1'AT1'GTIT GGCATTCCTA AACATAAGGA COCTACAGGA 120 AGCCATGCGT TAAATAAGGA TCACATTGTC GCAAAAGCTA CGAGAGAAAT TAAAAAACGA 180 TTT AAGGATT TGATCGTTAT AGCGGATI'TG TGTT TTGCG AATACACCGA CCATGGGCAT 240 TGCGGGATTT TAGAAAACGC TTCTGTGTCT AACGATAAAA CGCTAAAGAT TTTAAATCTT 300 CAAGGGCTTA TTITGCTGAA AGCGGTGTGG ATAWTC 336 INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 195 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No *9*9 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .195 (xi) SEQUENCE DESCRIPTIONi: SEQ ID NO:S GTGGAAAACA ACAAGAGTTT AAAGCATCCG AATGAGTTAA GGGATAAGCG AGATGAA FTA GAGTI'CATIT TGCGAGAGCT TTCGGGGGG AATGTTI'TA AAAGCAGCAT TAAAACCCAT 120 *.to TCGCTCACAG ATAAAGACTC AGCGGA= GATGAGAGCT ATAACCTIAA TATCGGGCAT 180 GGGYTCAATA TSATA19 00 a INFORMATION FOR SEQ SEQUENCE CHARAC7E._F2::ZS: LENGTH: 1257 base Fairs TYPE: nucle:c acid STRANDEDNE-S"'; ==zble TOPOLOGY: circ- ;ar (ii) MOLECULE TYPE: DNA (genomnic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: 0 NAME/KEY: misc feature LOCATION .1857 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:6
GTGTTTCTGG
CAAAAGCGGC
CCCTI'TTTA
ATT1'ATTCTT
GCCTATGAAC
AAAGAITACA
TTI'AAGGGCG
ATGGCTAATG
TCCTATCTAG
TATTCTC~T
GATCTCATAG
TTCAAXATTTT
TATGGTCTTA
AGITTTTATG
GAACCCGTTA
ATTIAGAGCCA
AAATACCACC
TGCGAATTTT
GACTTGTATC
CATGGAAAAA
GAATACGCCC
ITTATCTTTA
TTCACCTCTA
TGCTTGAGCG
GTGCTGTTTG
CTTAACGCTA
GCCAAACATT
GCTGATTICA
GGCAATAGCG
ATGCCCACTG
TCAGGTAAGA
CAAGCAAACA
AGTTITCAAAA
AAGTCITGTT
CTATATTTAT
CTGTITGAT
GGCTTTATCA
TGAAAAACAA
ACATCCACTT
CGAATAACTA
TAGGCACAAT
AGTTACACGC
ATTTTCACAC
TTTTTAA
ATATTAGTTT
TGAATAAAAA
AGCTTGAAAA
CCACTAGATI'
ACAATTTTCT
TCAAGGAAAA
TCTTAAATGA
CTAAATCACA
TGCATGCTTA
GAAGGATI'AT
AX'ITAGTGGG
CTGATAGCTT
AAGGTTIIIT
GCTCTTI'TAT
TAGCGATGAG
TGATGACG'T
ATTTTGGTTC
ACAGTGTTTA
AGCTGACGAA
AATAGAAGAA
TGATGGGGGG
ATTGTTTGTA
TGTAGCGATT
AAGAATGGAG
AGCGITCATG
AAATCCAAAC
TGAATGTTTT
CAAATTGGGG
TTCTAT'ITAT
TGTI'AAAAAG
TGATTTCATG
TTATCTCACC
GCATTTI'GCA
CTTCAAAGAT
AAAAGAATAC
TGTGGGAATG
AATGCATGGT
CGATTTGAGT
GAGCGATI'TG
TI'CGCCTAAA
TATTAGTGGA
TAATGGTGAT
TGAAAAAATG
AGCCAACGCA
CACGCTTCCT
AGCGATGAGT
AAAAAGCGAG
AGCTI'CAGCA
TGTCCATGAC
CAA.AAAAAGC
CITAAAGCAG
AATAGG'rTGT
ACAATTGTAT
GTTATI'GTGC
CGAGCGATGA
AGCATTT
AGAGAAGACA
TTAGATGATG
GGCATTGATr
AGCGTI'ITA
AAAATCGTI'A
CGAGCCTATA
ATAGAGCAAG
GACAATAATT
AGGATAGAGC
ACTAAAGATG
AATGAAGCCC
GGGGTGAAAG
GAAAAATATT
TTTGATAAAA
AACTCACAAG
GGCTCCAAAG
ATTACGCTAG
AAACAAAGCG
GCGACTTTCT
TTTATTITTG
TTTGATGGCA
ATCAATTCGC
GGACACACTT
TCTAAACGCT
TAGTTATAGA
ACATGCAAAA
TTGGITT'ccc
TATCTGTTAT
TTGTAGCTCT
AATTTAAAAA
CCATGAAGCC
GGCTTGTGAG
GGGTGATCCT
TTI'TAACCAC
GGAATTTTGT
TTGATGAAAC
ATGAGAAGCA
ATTTATTAGA
TTGAAGAGTT
TCATAGAAGA
GCATTATA
CTTTTATTrG
AAGTTTATTT
TTAGCGCTAT
TCAACGCTCT
TTTTAAAGGA
AGCAAGGCAT
GCAGTTATGG
TTAAGGAATG
CTATGGAAAA
ATGTAACTTC
AAGAAGACAA
CTFTIIArT
TGATACTTGG
ATGGGGCAAT
GCAAGAGGTT
GGGTGTCAAT
TGAAACTT
TCTrTTCAA
TGGA'T~CAAG
ACCTrrrrTG
TAGTAAAGAA
CGCTGCAAAC
TACTAACAAC
TTCCAAAAAA,
TACCCCTGAA
CAATAGGGAT
AAAGAGAGAA
CACTCTCAAT
TCAAAGGAI'
GCTACTGAGT
CTCCAAACAA
CAACAGAAAA
TGCCAATAAG
TGAGATCAGT
AGACAGCGAA
CAAACTAGCT
GACTTTGGGT
TAATTCTrA
CGTCTCTAGT
TTACI 7TTT TAACAAT1I7TI
TAACGCT'GG
GAAC'IWCCAC
CTCAACCGGT
TI'GCCTA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1800 1857 to..
to :t .a..0 INFORMATION FOR SEQ ID NO:7: SEQUENCE CHARACTERISTICS: LENGTH: 330 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE:- ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .330 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:7 GTGAAAACAT CGTGTTTGGT TACAATAGGG AGGATCCGGG CAGTTGTTGC TI'CGTGAGGG AGGTTATG AATTTTACCG GGGCATTC ATTTGTATGT GCATAAGGGG CATACGGAT ATTAAAACFI' TATCCATGAA ATTAGCGCAA
GGGTTGCCTA
GCG'FFI'TTAT
CTTATAACAC
TAGGCGAGGG
AAGAATGGAG
CATTAAGGCG
GAAGACGCCA
TGAAAGGCcTG
GGTITT~CCCT
120 180 240 123 AGCAATGAAT GGCCTAAGGA A TTI'AATATT TTAGC TTTAC CTTATGAAGT GTTTGCAAAA GAGCGCGGGA GCTCTTGGGC GAAGCA TTT A INFORMATION FOR SEQ ID NO:8: SEQUENCE CHARACTERISTICS: LENGTH: 204 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicabacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .204 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:8 GTGGCTAAAG ACATCATCAG CGAGTCTCAA AACCTTrGCG CAAGAAAATT CCGCCGTTTG TATGCGTTAT TGAAAGAAA.A TGAAATGCTC ATTCGCATCG GATCTTATCA AATGGGGAAC GATAAAGAGC TTGATGAAGC- GATTAAGAAA AAGGCTCTAA TGGAGCAATT TTTAGTGCAA GATGAAAACG C=I ACYAGC C TI' INFORMATION FOR SEQ ID NO:9: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 1338 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1_ 1338 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:9
S
ATGAAATCAC
GCTITTI'AG
TI'GATCAAGC
TATATITACA
AAACAGCCTG
AGCTTGTATG
TGCATGTTT
GAATATFI'AA
AAAGAGCTI'G
GCCCAATCCT
AAACCATT1
AGCTCAAGCC
TGGA'I7TTTC GCGT1'AAATA
AATTGCTCCC
ATCAAATAGA
AAATCGCTAA
AATTGAAAAT
CGCACAAGCT
AGTGGAAAAC
TAAATACAAC
TATTGATTI'C
TTTTGGCCCT
TTTGGTTCAA
GCGTTGTAAA
AGAATGTTTA
GGAGCGCCT
TACGCGCTCC
GAGCAAGACG
ATTCTITTTAA
CCTATCCCTT
TTrACGAGCG
AAGAAAAAT
GCCCCATGCG
GAAATGATI'G
TCTAGTAACT
AA.ATGATGGT
CI'TTGA'TT
GAGACGATAA
TAATCACACG
GGGCTAAGGA
GCATCAAGGA
AGGATAAAAT
AAAATAAAGA
TGCGTTFGA
CAAACAGATC
GGAAAATTCT
AACTTACCCT
AAAAATC'rrA
TA'IIGAC
TAAAAAGGCA
CACTAAAGAA
CAGGCTCATC
AGAAGCCTTA
120 180 240 300 360 420 480 540
ATTITATAGGG
GCCAAACTCT
GTGAAAATGT
CTCAACGGGT
CATTTGCCTT
GAATTGCAAG
AAGGGTGATA
CAAGAAAA.
GAGTGCGTGC
GTGGGGGGAA
CATCTAAAAG
GACTrCTA
AACATCGCTT
AAAGAAAAAA
ATAGGATTGC
ACGATTGA
TCATGCGTGG
TTGACACTGA
TGATGCCTGA
AGITATCTC
AGCTCGCTTr
CCTCTAATGA
CTTATAGGGT
TGGTCGTGTA
GCTCTA.ACGA
AAGAGCCACC
TAGAAAITIT
GGGGATTC
AAAAATCCAA
TATTGCT
GGGTAAAATC
TGAAGCGATG
ACAAATCTTA
TCACCAATAT
AATAGAAATC
AGATCGGATC
AGAA.ATCTTT
TGAAAACAAT
ATATGATCAA
GCCTAATTTG
AAAAAGCAGC
AAAATCGCCC
TTFI'ATGGTG
ATTTCTTCAG
AAACAAGCCA
TTGAGCGCTT
TCTAAAAAAA
GCTATGAAAA
TTAGAAGAAG
GACACAAGc
GCATTTCAAA
ATGAGCGAAT
TGGGTGATAG
GGGAGT'TG
CTITCACITG
GGAACAACAA
CGTTTGAAAA
TTATCAATCA
GITCTAATGA
TCGCTCTrAG
ACGCTCAAGA
CGCGATCGCT
ACCATI'CAAA.
AAGACTCTTA
TGCTCACCAG
ATGGAGGGAG
TAGAAGTGAT
CATGGATTTA
GGCGGTGTTA
AATCCACTCT
TTACCAATCG
AACGCTTAAA
CATTCCTA
GA'FrI'1TAGC
CTTCAATTTA
CAGCCAATGC
TCGGCGCTAC
AAGGGCTTTA
GGCGCAATrA cGCTATTTCT 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1338 INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 252 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genornic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .252 (xi) SEQUENCE DESCRIPTION: SEQ ID a a
GTGAGTTTGG
TTGAGCGA~A
'ITCAATTCTA
TCTCAAGTCG
AGAGCGTTGG
GGGCGFI'TCA GGGGTArI'AT GGAGGGCTAG
'TGGATTTAGT
TTTGGAGCGC GATCCCCATG CITTI'TTAC TCATTGTGAT ATTTTTGGAT CATCTTGTTT TAGTCTTGC TCTTTAGCTG TGCGCACGGA GTWFITAAAA GCAAGGAATA
TGGACTACAC
GG
GGGGCAAAGG
TTCTAGCGCG
GATGGGGCT
CAAAGCCGCT
120 180 240 252 a INFORMATION FOR SEQ, ID NO:l1: SEQUENCE CHARACTERISTICS: LENGTH: 120 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL, SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .120 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:11 ATGAGTGAAG CCTATTTTT ACACCATAAA AACGCTTCTC AAGTGTCTCT TAATGAACAA GTTTAAACG TTATGAAACA AGTI'CAATTG GATGAAAATT TTTGGAATGT TTCTCTTATG INFORMATION FOR SEQ ID NO:12: SEQUENCE CHARACTERISTICS: LENGTH: 900 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .900 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:12
C*
C. C
C.
C.
CC..
C
OC*C
C
GTGATCCTGA
TCAAAAAGAA
TTI'GTAGAAG
GGCATTATTT
GAAAATGAAG
AGCAAAAGCT
GTGGAAA.TGG
GATCCTAATG
AAAAATAA
TTTTGTGAA.A
ATCCACAGAG
GTTTTACTAG
TGCCATATGT
CAITATCAAA
AACGACCACA.
TATTTATCAT
AAAGCCAAAG
GGGCAAAAGC
TTGGGCATGC
CTGAAAGAAA
CTGGCTCTAT
AGTGGGGAGA
GCCTT?1'AAA
AGAGCATTTA
GGATCTGCCC
AGGTAGAGCG
ATGAGCTITI
GTTCCACTTT
AAAACCCTAA
AGCGTGGCTC
CGTGGTGGAA
CTCTGTGATC
GATTGAGGGG
GTTAAGCGGG
AGCGI=GAA
TAAAGCCGAA
AAAAGCT'AT
CCCTGATGTG
CCCTATTGAA
CAGTAAAGAT
TI'GAAAGAA
AAAAGAGTCT
ATGCCCTTTA
AGGCGAA.AAG
GTT=TCTT
GATCAGAAAG
ATGAAGACG
CT'ITTAAAAA
AAI'TTGCACT,
AATTAG=r
CATGGCACAG
AAGATCCACA
ATCATCACAA.
GAGCATTTGG
TTATCCTAA
AGGGTAAGTC
GAATACTTAG
GC;GATTGATA
ATCGC'rrCAA
AAAARGCGCT
GCATTTTCCC
TGTGCTTCAG
AACATGGCTT
TTGTCG'ITAC
CTGAGATGTT
GCAGGATGGT
AACA.AATCAA
ACGATAAAGA
-ACATGTGCAT
CGCCACGACA
ATGGTCATGA
CGCATGCCAC
CCGGGAGYAT
AGATTCTTAA
TI'CGTGGTTT
TATCGCAGCG
CAAAGAGGAT
TAAGGATAAT
GCCGATTCTA
TITAATGGTG
AGCCCCTTTT
GGAATGTTT
AATCCACACT
GGAATGTGGG
ACGCATCGTC
TGAAGATCAG
ITGCGCGGTG
CGCITrAAAT
ATCACATGCA
CAAAAACTCA
INFORMATION FOR SEQ ID NO:13: SEQUENCE CHARACTERISTICS: LENGTH: 642 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) Ciii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: CA) ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .642 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:13
ATGAAAGAAA
ATCGTGGTGT
TTCAAGGGTC
TT'TAAATCCA
CCCATITTGC
TTAAACAACG
AAACCCGCTT
CAGCCCAGAT
TTGTTAGAGG
AAAGAAGAAT
TCAATTTTAA
AAAACT'ITTG
TTI'TAGTGGT
ATAACGAAGT
ATTATCGTT
CCTATTTTTC
CTTTGAT2T
TAGATTCGCC
TATTAGGAAC
GCGATAAAGT
TGA~TIGGA
AAAACGCTAA
GCCTTTAGGA
GTTTGCCCTA.
GGATTTAAAC
TTCAGTGGGT
TAAAGGCACG
AGAAAAGTCC
AAATATTCAA
GCTTGATTGT
GGGGCGCTAT
GCAACTGCT
AGCATrTITT
ATCATGAGCG
AAAAATTCGC
TTTAACGCCA
TTAAAGCCTC
CATGGGGATA
AACACGCFI'T
GTGTATTTAG
AAAALACGCAT
AAGATCCTTT
TTITTAAGTA
AAATACAAAA
TGCTATT
CTAAAAATGA
TGCTTAAAAC
TTACCGAAAG
AAAAAATCCA
ATGCACAATT
CGTI'CTATCC
GCGAACC='I
TTAAATTI'GT
GCATGGCTTG
TA
TGGGCTTGGG
TTTAGTGTAT
TTATGAAAAC
CCCTAAAACC
AGAAAACCTT
GCAACCGCTC
CAGCCAATCC
AAAkATTTGAT
TTTTAAAA.AT
TATGGGTATA
S
S. S S S INFORMATION FOR SEQ ID NO:14: SEQUENCE CHARACTERISTICS: LENGTH: 411 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .411 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:14 55 S S 555 5
ATGCCCATITA
GTGATTATCC
AAATACCAA
GAGCTTTTAG
CTTTTAAAAG
TGCGCGAAAA
TACGAGCTGT
AAGGCTCTTI
CCCAAGCGGA
AACCCTI'GTT
AAAAAGGGCA.
ATTACCAT
ACCCTAGCTA
TGGGTAAGAT
TTTAGCCAGA
TTTAAAAAGC
TGTTITACCC
GGCTCAAGGG
AAAAGAAATG
TGAAGAAGCG
TAAGCGCATC
AACCGCCTGG
GGCTCTATGA
CAACGCCTGA
ATATTTAATA
CCTGAAATGA
TATCTCAAAT
AATCATCTCG
TGATCGCTTT
GCAGTGCGAG
ATGAGAGCGA
T1'CAAAArITr
AAGATGAATT
TTGGGGATAA
TGGTGTTAGC
AACCGATGCG
ATTAGCCCAG
CGGCACTAAT
TATAAACACC
TTTAGAATAT
GCT'TTTAGAA
A
INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 816 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .816 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:lS
ATGGTAGTAG
GGCGTGAAT
GGGAAATCCA
TTAGTCAATG
AAAATAGGCA
GTCGCTITCG
GAATTGT1'GG
GGCGGGCAAA
CTTTGCGATG
CTAAGCGGCA
GTGGTTAAAG
GGCTCGGTGG
ATCAAAAACG
GAGCA'ITTAG
AATTAAAAAA
TGGAATTGAA
CGCTCATTCG
GGGTCAATCT
TGATTTICCA
CTCTAGAAAT
AA'DTAGTGGG
AACAACGAGT
AAGCCACATC
TTCAAAAAA.A
AATTGTGCAA~
AAGAAAT'rr
AACATGCGGA
ACGAGCCGAT
CA ITGAAAAG
AAAAGGCGAT
CTTGATCAT
GTTAAACTTA
GCATTTCAT
CGCCCGATGG
GITAGAAGAT
GGCGATCGCT
CGCTTTGGAT
GITrGATTTG
TCAAATGTGT
TGCTAACCCT
TCAAAAATCG
CATTTCTAAW
ATTITATGAAA
AlTI'IGGGCG
TGTTTAGAGC
AAGCCTAAAG
TTAITGAGCG
GAAAAAACTA
AAAGTGCATT
AGGAGTI'AG
TCTAAAACCA
AGCATCGTTT
GTGATCAGCA
AAACATGCTG
CAAGACAT
TTITGW
ACGGGTTTCA
TGATAGGCTA
GCCCCAGTTC
AATTGCAAAA
CTAAAAACGT
AGATAAATC
TTTATCCTAA
CGAATTGCCC
CGCATTCTAT
TCATCACACA
GCGGCGAAAT
TTACTAAAGA
ATCGCATCGT
TGCTCTAAA
TTCAGGGGCG
TGGCGAAGTT
AGCGCGCCAJA
GTI'TGAkA.Ac
AAGGGTGCAT
ACAGCTCAGC
TAATFI'GTTG
TI'TAACGCTT
CCAGATTGA
CGTAGAAAGA
ATTGCTTGGC
GITTTTAGGG
120 180 240 300 360 420 480 540 600 660 720 780 816
S
S
4*
S
S
S
S. a a *5
S
a a INFORMATION FOR SEQ ID NO:16: SEQUENCE
CHARACTERISTICS:
LENGTH: 318 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 318 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:16
ATGGGGGCTT
GAAGATAAAA
GCCTFI'AGCT
ATCCAGCTCG
GTGTTAAAA
GTCCCTrGA
TGATAGCCAT
AGAGCGCGGC
GGTATTTGAT
CTIGCGGTTG
AAGCCCCGCA
TTTTIGCC
GTITTTTTTA
TTAAAGGTC
CGTGAAGGTT
TGTCCTTIGCG
ATTAGAAAAT
ATGCTCATTA
GTGCCTTATT
TTAAAACGCC
CTTGATTT'
AGCCACGAAA
AAAAGACTAT
TGGTGGCGTT
TCTATGCGGT
TTATCCT?1111
GCGTCAXA
CGCTTATAAA
GATGAGCTTA
GAGTTrTGAA
TAAAGAT
GCTTTTrAAT 120 180 240 300 318 INFORMATION FOR SEQ ID NO:17: SEQUENCE CHARACTERISTICS: LENGTH: 471 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .471 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:17
ATGATTAAAA
GTGAATGGGT
AATTACTCTG
GTAGG.CT'rrc
ACTTCAGGGA
ATTGTCAATC
GCCGGAAACA
AATTTAGGCG
GAAT'GCI'G
TTTTCATGGG
ATTGGCGTCA
CCAATAAATG
CTGAACACAC
TCATTCCT TT
CTTGGATGTI'
GAAGAATGCG
TATTTTAAGC
TGCGGG'ITAT
TGGCAATGAC
GTTTGGGGCT
CAAAACCAAT
GGATAAXITC
CCCTTATGAT
TGTTGGGGAT
TTGAGCGCGA
CAACAAGGTC
CTTTATGGTT
AGGGTGTATG
TTGCTCACCT
GCTCTAGGTC
GTCAATCAA
RCAGTGCGTT
GTTTAGCGTT
GTTATGGCCC
TGAATT~CAA
GCTTT7TTAGA
ATGGCGGCGG
TCATTGGTGG-
CCAGATI'CCA
TGAAGCGGGC
AGCTGGCGAA
ITATAACAGC
ATTAGGTTTT
TTGG'ITTAAC
TGGCGATTTG
CGTTCAATTA
GTTCTTATGG
G
120 180 240 300 360 420 471
S.
S
S
S.
S
S
S. S S. S
S
*5 5 INFORMATION FOR SEQ ID NO:18: SEQUENCE CHARACTERISTICS: LENGTH: 834 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .834 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:18
ATGTATCGCC
CTGTFI'AACC
ATGGTGGTGG
ATTGAGCCTA
AAAAAGATCC
TTTCATCT
GGCCAGTTGT
TITIrGTCT
AAAATGACTA
AAAGCCAAAA
CCCAAATCCA
GAAGAACACC
AAGGGTATCG
CITIATAGAG
ATGTGTTGAA
AGCTGGCTAA
CGTTTGTC
AATTTTCTAA
TIGATGGGAG
ITrTCCTTATT
TGTGGTTI'AA
TGGCTTGT
AACAAGAAGT
TCCGCCAGAT
ATGTCGTGGT
CTGTGCCTGT
CCAGAGAGCA
ACGTGAAATT
AGATT'TCTCC
AGACACTTr
TAATGTCTTG
AATCAACCCT
TTTGATCACT
TTI'AGGGGAA
AAGCAAGGCG
GGATrTAATC
TAAGGACGAA
GATGGTAAAA
GACTAACCCT
GGTAGTGGCT
TGACATAGAA
GAACGCCACC
CTAGATITA
TTAITGCT T
CAATI'GGCT
ATCAATGGCG
ITAAAAGTT
TTAAACCATG
TTATGGCTCA
ATCAAACGCC
TACAAACAGC
AACGCCACGA
ACCCATTATG
AAAGGCACGG
ATTATAGAAA
ATACCAGAAG
GCAAAGAAAG
TGCCTGT177IT
GGCTCTTTGC
TCAAAAACCT
TTTAGCTTT
CGGCTCrIT
TITCTTCGCT
GCCAATACAC
AAGAAGGAAA
ATAAAATGAT
CCGTCGCTCT
ATTATI'TAGC
ATAA.AACGCT
AATTGITTGA
CGT TCAAGAG AATCAT'ITrA
CCCTAAAGTC
ITFTTCTTTA
TTITTCTGGGG
GAATTTGCAA
T1"TAT1'TTTA
TAACTCTI'TA
CCCAGAAATC
GCAAGAAATC
CAAATITGAT
CATTAGGATT
COCTAGAGAG
GCGG
120 180 240 300 360 420 480 540 600 660 720 780 834 INFORMATION FOR SEQ ID NO:19: 129 SEQUENCE CHARACTERISTICS: LENGTH: 360 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 360 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:19
ATGAATACAA
AGAGAGCCAG
AAGTTCGCGC
TACC 1TTTAG
TTCTGCATA
TTAGTTGCGT
GSCCCTTAAT
'FIWCTTTTCA
ATGTTTCTAG
AAGACAGAAG
AAAAACAAGA
TATTATTAGA
CGCTACGCTT
GCCTI1TTTAC
CATGCCCAGT
CCTATTGGAT
XITI'GACGCT
TGCGAATTI'A
TTGCAAGCGC
CCCAAAACAG
TTGGAATTTT
TTAGCGGTGG
TI'ATGTCAAG
CCCCTAAAAA
CTTTGCATGT
AAAAGCCTAA
TAGAAAAATT
GTTATATCCA
AAAAATTGGA
AAGGGGGTTT
TTTAGGGATT
TCGCCCTCAA
GGTGATCCGC
TAGTGGGGTA
CGACCCTAA
TGAAAAGGAA
C C INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 678 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 678 (xi) SEQUENCE DESCRIPTION: SEQ ID '00 *00
ATGGGGCAGG
TCTAGCGCAA
GTGGTGAATA
T1'AGACAATG
GG'FITCAATA
TCGGTAAAAA
GAITACCAAG
TTAGAAGAAC
GCACAAAAAG
GAAAATCTCA
GAAI'GATCA
GCAAGAGCAG
CATIITAA
TAGAAGCAGT
AGAAGATITGC
'ITACCGTGAT
AAGGI'GGAG
GTAATCTCAT
AATTTTTAAA
AAAAAAAAGC
ATAAAAGAGA
CTAACGCTAT
AGCAACAGAG
GCTCAAGC
AAAAATTGTT
AGCACTTGAC
TTATTTGGGA
CCAACTTGAA
TATTGTGCCT
GT?1'GAAAAA
GACAAAAAAA
TCTAGAAAAA
AAAAAGAAAG
GAGTAACCCA
AGAAAATGAA
GGCTGTTTCT
ATTAAGAATT
GATGAAAAAC
AAAGATGAAA
AATTCTAATC
GAAGCAGTGA
CTTATCGTAG
GAAAAAGAAG
GAGGAGCGTG
CAAAATI'TGA
TTAGACCAAA
GTCTTGGTTA
TTAATCGTGG
CTATTACGAT
CTATTTCITA
ATATAITCAT
AI'ITGCCCT
ATGCGCCTGA
CTAAAGAACA
CAAAAAATAG
GCAATAACAA
TGGAACGAAC
TATTrTA
TAGGGTGAAA
TI'GGACTTCA
CATCACAACA
TCAACCTAAA
AATGACAAGA
CCCTAAAGAA
GGCGCAAAAG
AGCCAAT'ITA
AAATCTTAGC
TAGAGGACAT
120 180 240 300 360 420 480 540 600 660 678 INFORMATION FOR SEQ ID NO:21: SEQUENCE CHARACTERISTICS: LENGTH: 150 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...150 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:21 ATGAATACAG AAATTTTAAC CATCATGTTA GTTGTCTCCG TGCTTATGGG ATTGGTAGGC TTAATAGCGT TTTTATGGGG GGTTAAAAGC GGTCAGTTTG ACGATGAAAA ACGCATGCTT 120 GAAAGCGTGT TGTATGACGC GCGAGCGACT 1 150 INFORMATION FOR SEQ ID NO:22: SEQUENCE
CHARACTERISTICS:
LENGTH: 390 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori o (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...390 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:22 ATGTTTGTAG CGGCCGGGCT TGGGGCTTAT GCGATCGCGC TTTTCCACCT CTTTACGCAT GCGTTCTTCA AATCCCTCCT TTTCTTAGGC TCAGGCAATG TCATGCATGC GATGGAAGAC 120 AATCTGGATA TTACTAAAAT GGGCGCTTTA TACAAGCCTA TGAGGATCAC AGCTGTCTTT 180 ATGATTATAG GGTCAGTGGC TTTGTGTGGG ATCTACCCCT TTGCGGGCTA TTTCTCCAAA 240 GACAAGATTT TAGAGGTCGC CTTTGGGATG CACCACCACA TTTTATGGTT TGTTCTTTTG 300 ATTGGGGCGA TCTTTACCGC TTTTTATAGC TTCAGACTCA TCATGCTGGT GTITTTTGCA 360 CCCAAACAAC ATGAAATCAA CCACCCCCCA 390 INFORMATION FOR SEQ ID NO:23: SEQUENCE CHARACTERISTICS: LENGTH: 549 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 549 (Xi) SEQUENCE DESCRIPTION: SEQ ID NO:23
ATGTTTATAT
TI'CAAAAATA
AATATCGCTT
TTAAG CC CCT AAAAAGC C CC
CTTTTGACAG
CTGKTITTA
ATCGC'rTTAG
TCTTTATTGG
AAAAGGTTA
CI'CTTCTTA
AGCCATTGGG
TGAAAGACTC
TTAGCTGTCT
CTTTAGAAAC
ATATI'TITAGG
GC-GCGC'i-.rTl
TGGCTTTATC
ATTITCCCATT
CACGCTGAGT
'FITGAGGTTT
CCTATCGCTC
TTTGATCCTT
CT.TGCAATCT
GTITI'TGCCT
TI'GCAGCAGT
CAGTTCGCTr ATTTC.T T77T
TTTGTATGGC
TCGCTCTCTT
AATGAATTT
GCTTATGCAA
TATAGCGTCA
TTI'TCAATCT
TTGTITI'TGA
TTGATGCGTT
GTCTTT TTTA
TTTTTTAAT
TGATAAGCGT
TAAGCAGTTT
GCTTTCTTG
TGCTGTTT
ACCATCXI'rT
GTAGCCCCT
CTAATTTTCA
AGACTTTATA
TTI'CTTTTTT
GATTTTAAGC
TACAGCCCCC
CCATATACTC
CAATCTGTTG
CATGGCTTCT
ATTAGGCGTG
AATCTTAGAT
TCTTGCTAAA
120 180 240 300 360 420 480 540
C
0*OO p Se 6 9 'see t 9 .5 9
S.
set.
55 5 5 INFORMATION FOR SEQ ID NO:24: SEQUENCE CHARACTERISTICS: LENGTH: 705 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 705 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:24 050 00*
ATGCGCCTAG
GCGTTGGTT
ATCGTI'AAAG
GGGGAAAAAT
TTAGATGTGG
AAGGTGCTTr
CGCATAGAAT
TTAGCACTTr
TTAAGCGGTG
CGCAATAAA
AAAAACCA'T
A?1'ACGCCCT
TAAAAAAACA
AGGGCGATCA
TAGGGGC'TrT
GAGCGAGTAA
GCGTGGATGT
GTTACGAAGA
GTGATGTGAG
AATrI'TTAAC
AGGGGGTGGT
TAAAAACAAA
ATTCAACCAG
GG~T'TTAGTC
AATTGAACTC
TITAGAAGAT
GGGAGGCTTT
GGGGAAAATG
ATGCGATAT
CITA'TrTCT
GCITTCAAA
GATGGATAAA
GGAI'ITCAA
CAITTAGCAA
AATAAAATGG
ATCGCTCCCA
CATI'TTATAG
AGTCAAGTGG
CAATTAGATG
AGAGGGTTTA
TTATATTGTA
CCGCAATTTG
GAAGCCAT
ATCTTAACGA
ATACCAGAGA
TGGTTrCTAA
ATCTATTCGT
ATTFrAAAGA
CTCTTTTAAA
AAGITTGAA
AAACGCCAGA
TTTTAGAAGC
AAGTGGGCAG
TGAACGCT
TCCAAGWAG
AAAAGCTAAA
ACCCTCT17-'
TAGCAGGGCT
AAAGGTTcGrr
AGGGCTAAA
AAAcGACCAA
AAAAATTGAT
GATTTTGCCT
AACAATAAAA
AGAAAACTTT
CTTAGTGAA?.
GGGAAAAACG GGAATGTITGA XFTTI'TATC CATTTCAAGC
GAGCC
INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 264 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc feature LOCATION I1.. .264 (xi) SEQUENCE DESCRIPTION: SEQ ID
ATGAGCCTAC
TC ETTGGTGG
AACGCTGACT
GCGAGCGGCA
AAATTTITAG
CACCGGTi'TG
CGTTAGGCALA
ACATTATAGA
CGCCTTTAGA
CTTTGGAATT
CATTGAAA
GATGTGAATC
TTCCATGCTA
'GTGATTGAGC
CATGGGGCCT GATGGGGGGG AGTGGCGCA
AATTGCGAA
GAAA
ACCTTTTACA
ATAATTTAGA
ATAAGGGCGG
AAACcAAAc
AGTCTTRCAT
CATCATCAAA
GAAAGTCATT
CTATACGGGA
INFORMATION FOR SEQ ID NO:26: SEQUENCE
CHARACTERISTICS:
LENGTH: 444 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .444 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:26 4
ATGCAAAATC
TTCACCAAAG
GCGTITrTIGT
GTGGTGTTTG
AACTATIGA
GTGCCTIAG
AGAATCTATT
AGCCCACC
GATCGCATGA
AGCTTGACAA
GGCTCAAAAT
AGAGCATCAA
TGATGGGGGA
AAAArI'GGCT
TTGAGGATAG
AGAGACAATT
AATACAAGGC
TTATATCAGC
CGTAGCCATA
CGCTACAGGC
AAATYCTGAC
TGGTGAAAAG
AGTTACAAGA
TCCC
GTATCACACA
AAAGGGTATC
GGTrAGAGT GTGCA.ATrAA
AACCAGAATC
GA'TTTGAATG
GGGAGAGCGC
TTAAGAATAA
GCATI'GAAGA
TGGGCGAAGA
AAGGGCTGGA
GTCTI'rATAA ATFI'cATcAA
GAAGTGTATT
TTATAAATT
GAITrATGGC
CGATCCGCAA
TCTCATCCGC
TAC'FrA'GG
AACCTATITTG
ACGCGCTAAA
120 .180 240 300 360 420 444 INFORMATION FOR SEQ ID NO:27: SEQUENCE CHARACTERISTICS: LENGTH: 321 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc feature LOCATION .321 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:27
ATGGATACCA
AAATGTGTTG
ATTCTTGTTA
TFI'GAATACA
CATGTGTI'CT
AAATATCATC
TAAAAAGCAT
TGTTGGCATC
TGATAAAATT
GCTTGCTGTT
CAGGAAATT
ACTCAGCTTG
TCCCATAAGA
AATTACAGTG
GATTGATAIT
ACCAACTTTA
TATCAAGCTT
ACTI'ATTT
CTATTTGTCG
GTGGTGAATC
CTACTATGGG
GCAAACCATT
TACTCTATAA
GCATTCTTYC
TATTACAAAA
GAGCCTTGCT
ATTGCCGAAC
AAGCTCACCA
ATCTCTGAAT
GCATACGCAT
GTTTITAACG
AATTTTCTAT
INFORMATION FOR SEQ ID NO:28: SEQUENCE CHARACTERISTICS: LENGTH: 408 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .408 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:28 .11 00 ATGATCIT71I 7TI"ITIGGCA
ACCTATTCTT
GACAGCGCCC
AGCTTGAATA
ATI'AGCGGGT
TATACCCCCT
ACACCACCAT
AGATCAAGCC
TTCTTTAAC
ATTCCAACGC
AAGACTTIAAG
TTCXITTTAGG
TACAAAAACG
TAAAGAGCCT
TTGTTCGTTC
GCGAAAACAA
CTTAGTGGGT
AGACAGGGCT
GATITTGAGC
CTATTTCCCT
TTAAAAAACC
TTAGAGTCTC
GATTCAAAT
AAITTGTATC
AACGCGCTAG
GCGAGCGTGT
TACAGGAACG
TCCAATACCG
TAAAATCATG
CGCXITTTGCG
GAGCGTTATT
GGATCAACCA
ATTTTCT TT
CTT'ITIWA
CTATGCGCAA
CTTTTTTCAA
CCATTTCAT'
CATAGGGGAT
CI'ACTGGCC
CTCTCTTTTT
INFORMATION FOR SEQ ID NO:29: SEQUENCE CHARACTERISTICS: LENGTH: 162 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .162 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:29 ATGAATAA.AC CATrI'TTAAT CTTACTCATA GCCCTAATTG AGAAAATACT TCAA.ACCCGC TAAACACCAA
XITAAAGCGA
TGCAAGAAAG CATCG'FTTCG TCTAATCGIT ATGGAGCCAT IN-FORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 375 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .375 (xi) SEQUENCE DESCRIPTION: SEQ ID CCTTTAGCGG CTGTAACATG AGCGTATTTC CCTAACCATT
TT
ATGGCGGCTI'
GGTTTTGTGG
ATCCATGCGG
'ITTAATGAAA
GAAAGGGGGA
T rITAGGGA
AGGCTTGAAA
GGAACACTTT
GCAAGTATTT
GGGCGCATCT
AGACTGA'rrT
ETGAGGGCAA
TTTGTTTGGG
GGGGC
AGTAGAAAAA
AAGCTrAAAA
GGATACGCAA
AGAGGGCGTT
AATITGCGCC
CATGCAATTA
ATCATCGCTC
GAATCTrATA
GTCAATATTG
GATGCGATTT
ATTCAAAGGG
GCGATCGTG
CTAAACACA
AATCCTTGAT
AATGGCTGGA
TAGTGCCGGG
CTAGGrI'AGA
AATTITGTCG
GGTCAAAATI'
TGAAGCCCTA
TAGCGAGAAT
GGGCTTTGGA
AAAACTCCCC
CAAATGTTTTT
120 180 240 300* 360 375 INFORMATION FOR SEQ ID NO:31: SEQUENCE CHARACTERISTICS: LENGTH: 747 base pairs TYPE: nucleic acid STRANDEONESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genornic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .747 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:31
ATGACTAA.AG
CTCATCTTAA
AAGATTGACA
TATGTGGATA
CTCTCTCAAG
TTTGAATTGA
GTTGATTTTG
GCTI'ATTTGC
AATAAAAATC
AGCGTGTT
TATTTCYAWG
GATTTGTTTT
'TTAGAAAAT
CrGTTTGTGCC
TCCCCACTTC
TTAACATCAG
AGACTGAAAA
AAAGCTTTAT
ATTTGTATAA
AAGAATTGCA
AAGGCACGGA
AAAAACGCCG
TAATCCCCTT
TCCTTGGAGC
TGATGACCTT
TCATTTTIAAA
TTTAAGTTTG
TAAGAGCGCT
AGCGGGTGAA
CAATTCCTAT
TTTGGCTCAA
CGGGCATGCG
ITTTGCGCAAC
Fl'AT1TGGGT
T'TITTCTCAA
ATTTGGCATC
GGTTGGGGTW
TITCTTCCCC
GCGITAT
TTAGTGAGCG
TATTACGGGT
TTCGGGCAA.
GATAATTrGG
AAAGGCAATA
TATTTCACTC
AAGCTCAAGT
TATI'GGAAAA
GCGATCTTAG
GCCAACCCGC
TATTTITTAA
TTI'ATT TGGG
CGATTTTATT
TTI'TGCGTCA
AATTAGGCGA
TGCT'rrTTC
TCAACAATCA
AAGGCGATAA
C'ITTCAATTC
AAGCCTTTGG
ITTCCTTCTT
GATTCAAAAC
TGGTGCATGT
CGTTATTTC
AGCGTTTTCG
AAAAAAAGAC
TTGGCTCGTG
TAATAAAAGT
AAACGGCGTG
AATGCGTA.AG
TAATGATGCG
TAAAAACGCT
CCCTTTAGCG
GAA'FrGGAGT
GATTTCTACG
TTATTTATTG
120 180 240 300 360 420 480 540 600 660 720 747 INFORMATION FOR SEQ ID NO:32: SEQUENCE CHARACTERISTICS: LENGTH: 258 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc feature LOCATION 2 .258 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:32
ATQAGTAAGA
'rTATIATATG
TI'AAATAAAA
AAGAATGAAA
AGAACCCAAA
GCGCGATTr TGTCTI'TCT GGCTFFITAG GTTTGTTGTT AGAAAGGCAT AATAAAGAAG AGGACGAACA ACCCATTGAC TTGAAT'FrAG AAATTRAAAA AGTAACGGAA AAACAGGACG
GAGGAGCC
CGTTCTTGCT
CAGAGAAAAT
AAGATCTGCC
ATTAGA
CTATGCTITG
CC'TTTAGAT
AAGCGAGAAA
GCCTAAAAGA
120 180 240 258 INFORMATION FOR SEQ ID NO:33: SEQUENCE CHARACTERISTICS: LENGTH: 384 base pairs TYPE: nucleic acid STRANDEDNESS; double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .384 (xi) SE:QUENCE DESCRIPTION: SEQ ID NO:33
GTGATGGCTC
ATGATCAATC
TATCTTGTCA
ATTTGGGCGA
TTGTTGATGC
AAAGAAAGGA
CTTATCATCG
AATCCTI'GCT
TGTYCATGCC
TTTACACCCT TTrTAAAGAA TGCCAGCGAT
TTATATTCTT
TGCAACAATT
TGAXTITCT
TCATTGCAGA AATCAA~cGc TGAAAGCCTA TATCAAAkA TGTTAATGGG
CATT
'FITTTTGCCG
AAGAAI'TTCA
TTAAGCATCG
TTTAGcGCcTG
CATAAAAGCG
GC-TAAAATCC
CCTTGCTCGC
TCCAATTGAA
CTCTTI'TGAG
TTGTCATGCT
TGAAATTCGC
TGTArrT-rr CCTAGccT..pT
CCGGAAAATC
TGGGGTTTTT
TTTGGc-T-G
TATCACTAAA
AGAAACGATT
120 180 240 300 360 384 a.
a a a a..
a INFORMATION FOR SEQ ID NO:34: SEQUENCE
CHARACTERISTICS:
LENGTH: 306 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (i)MOLECULE TYPE: DNA (geriomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: zmisz !eature LOCATION .3CE; (xi) SEQUENCE DESCRIP7:::: SE ID NO:34
GTGCGTAATG
AGTTA'IWGCA
AATGAAAATG
TTTGTGcA)JA
ACGCGCTG
AAAGTT
TGG'FPITATT
TGCcccATTA
AAAACACGCC
CTACGACCC
GCTTCCCTTr CAATA TAAGcA -z; 'FTAVrI-mAG;
GTCATTAGCG
C-AAGTAAAAA
AAAAGCGTGA
?I'TAATl'CGG
TAGCGTTCAT
GGGTGGAAGT
CCC'ITGCTAG
CCGTCTATCG
CTGATXAr-rC
GCTTTTAGTG
CAAAAGAATG
AGATGTCTAT
TAACGAAGAC
AGCTCTCGCC
120 180 240 300 306 INFORMATION FOR SEQ ID i)SEQUENCE
CHARACTERISTICS:
LENGTH: 264 base pairs TYPE:,nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .264 (xi) SEQUENCE DESCRIPTION: SEQ ID
ATGTTTAAAA
CI'GAAGCCA
GAAAAGCTCT
TA'FrTTTTAG
AAAGATTGGA
AAATCATTTT
TGCCTATTTT
ATAGAAGCAT
GGGGGGI'GG
TGCCACGCTC
TTT GTGCGTT TTTT GATAG GGGGATTTGT GCGCAATAAA ACCCCCAAAA AAAATTACCA CATI'AACCGC CAAAASSTCA CGCGTAAAAA CGCTGTAGAA GCCATTAAGG ACTATCAAGG
AATT
CATTCCACCC
AGAAGCCCAT
AAGCGGGTGG
CAAGGAAATG
S
*5*S
S
S. S INFORMATION FOR SEQ ID NO:36: SEQUENCE CHARACTERISTICS: LENGTH: 384 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .384 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:36
S.
S S
S
GTGCATTFIA
CAGGCGTGCA
TATCCCCCCT
TTTGGGGCTT
TGGATTGGGG
GGTGCGCATT
GGTCTTCCAC
CGTGTATCTr
AAAAGGCCAC
CAAGTAITAA
TGAGCAGCAY
GCTTTGAGCA
GCGAI-rGAT
CTTTCAAGGG
TCTAACCCTA
CAACCAGATC
CCCCTCAATC
Y ETAGAAGYC
TI'ATTTATCC
GCAAAAAGAC
GCTG
ITAAAATGGA
CATTCAAGGY
CAAGCGGGTA
CCCYTATITG
CCITTTATATG
GCCAATGGAA
TTITGCCAGC
YTGCAAAACA
TACAAGGGGT
llTIIYYAAGC
GGTGGGGCAA
GGGGTATCGG
CAAAAACAAG
TCCAGCAAAA
GATGCAAGGT
AAAATGTGGG
GATTCACGAT
CTTGGAAAAA
INFORMATION FOR SEQ ID NO:37: Wi SEQUENCE CHARACTERISTICS: LENGTH: 324 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .324 (Xi) SEQUENCE DESCRIPTION: SEQ ID NO:-37
ATGCAGAAGT
TTAGCAGCGA
GATCAGTTAG
ACCGATCACT
ITAGAGCCTA
AAAACGGFI'G
TT1'TCTCTCG
TTGATATTGA
TGAGCCTGAG
TAAAAGATCT
AGCCTAAGGG
AAATCGGAAG
TTTTAGAAGG
TGAAGTAACA
CGATAAGCTT
TAACGATTTG
CAAAGAAGAT
CGGT
TGGGCG'ITGC
GAAGCTCAAG
TTAGAAAAAG
CATGAAAAAA
AGTCCTAACT
CCTTTTATTT
CTAATAGCAT
CGGTGGATAG
TCAA.ACATTT
TGGGAGGTAA
TGTGAGCGCT
TAAATTAAGc
GGGGCGCAAT
GCGCTTGATT
TAAGGATATG
S
*9 S S *5 S S S
S
S
S S
S
S..
S
INFORMATION FOR SEQ ID NO:38: i)SEQUENCE CHARACTERISTICS: LENGTH: 354 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
Uv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori.
FEATURE:
NAME/KEY: misc feature LOCATION .354 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:38
GTGATTTI'AG
AITCCTITT
TTAATAGGGA
CCTGCTGGGA
CTGTATTI'AG
TGTTCAGGCT
CGITCGCCTT
TATCCACAGG
TTAGCGGGAC
TCATCGCCCC
GCGATACATT
TGCTCATI'GC
TGGCATGAGT
CGTTCATATC
T1'AGGGCAG
CATTGAATAC
TTI'GGATCTr
CTTGCCCGCT
CTTCTTGGAT
CCTAGAAAAG
TATTTCTTAA
ACCCGCATrG AAAAGCTCTr
C'TTTTAAAAG
TAGCGGGCAT
AGGATAT"IM
CCTATGCTTA
I"ITGGGGGCT
TAGGGGTOOC
AATTAAAAAA
GTTCATTGAT
ATGGATTTCT
CATGAACGCT
ATTGTI'TGGG
TTTGATCTI'A
AAT
INFORMATION FOR SEQ ID NO:39: SEQUENCE CHARACTERISTICS: LENGTH: 162 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .162 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:39 ATGATCTATT TAGGGAAGAA AAATTITTAAC GCCCTITGA GAGCAT'rITA GAAACGCCCC TTTGAA.AGC AA'ITTACCCG CGTGTGGTAT ATCTAACTFT TTTTCCAATC CAAAAAGCCA INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 864 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .864 (xi) SEQUENCE DESCRIPTION: SEQ ID AAGGGGCGTA TTTAATGGAT TT'ITAATGGG ATTA.ATCTGG
CT
@9 9 *999 9S 9.
99 9* 9 9 *9 9 9.
9 9**9 9.
9 9 9
ATGGCCGCCA
AAAATCACTA
CGTAAAGCCC
ATAGAAACCG
GGCGAAGCTA
CTCCCTTCTG
ACCAATG'ITG
GACTTTAATG
GTITTAAAAA
AGCGGGTGCG
GGGGAAATT
AAAATAGGCT
GCTTrTGGGA
TATGATTTTT
TTAGCGGCGG
AATCCAAAGC
AACTCAAAGA
ATGACACTGA
TGGGCTTI'AG
GAATGGTACT
TAACTGGAGT
TT1TTTAAAAG
AAAAAATCAC
ATITCAACCT
GAAAATCCAC
TTA'FTGATAA
ATATCCCCCA
GTGCTATAGA
TATGCGAGCA
TCAAAAACAG
GYAACG=ZW
CAACCA--GA
GATCA=r A
CCCA:,A=
TGAZ;:7
CGCA
AAAGTCTTT
GAAGCCCACA
TCCACTTTGC
FrAGCGGTCG
TCTATGTATG
TATAATGAAA
AC-CATCGTTIG
ATITCATTCG
;JAAGGTCAAA
ATTATTATGG
ACCAGCGAA)A
C -rr'IGATC 7TTGKIIAAGG
AAAACCCAAG
CAAAATFTTT
AACTTTGG
AAGTGGTCCC
CTTACATCTT
CCCTAGCGCT
TCGCFrACAA'
AAGAGGATTT
CTTATAAGTC
AAATCGCTCT
GGCTTACCTA
ACAGGCGCTC
GCACTGTOGG
TGTGCAAAAT
TGGGCGAAGG
CAGCAATTTC
AGAAAATAGC
CAGGTATTCA
ATTCAAATAC
TI'ATCGCATA
CCAGCTTGCA
AGTCCCTTTA
AAAACACCCG
CATAGGCCAT
CCCTAAAAGT
ATGGCGTAAA
GGATAATATC
GGCTCATATC
GGCGCTAAGC
INFORMATION FOR SEQ ID NO:41: Wi SEQUENCE CHARACTERISTICS: LENGTH: 576 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .576 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:41
ATGCTTGATA
CCTTACATTG
CCTG'FITTAC
CAATTATCCA
GGTTTGACGC
TTGGTGTTTG
TATACTACCA
TTTAAGGATT
ACTCTCATAA
'ITITCA
TATGGATAGA
TAGGCGATAT
TCCCACAAAA
TTATTTCTCA
ATTTAGAAGA
CCTTGTrGTI
TGCATI'TGGA
TTiTCAAAGG
TGATCA'ITGA
TGAT'FITGcC
TATGATAATC
TITGCAATTG
GGATTATGAA
AA'FrrrAGAT
TCTCACGCAT
TTTAGCGATT
TAAGGAATTr
ATTATTGCTC
ACATGTGGAG
TAATCTTT
TGTATTTTT
AAATTTATCC
GAAGCGGGAA
GGGGTGATCT
TATTTAAACC
CAAAGCG'ITTT
GrGCT I TCTA
ACTTTAGGCG
CXFI'GGGAGA
TTACCC
ATTTGCTCTT
GTCAAAAACT
AITATGCTAT
TTGCTGGTTG
TTCCTGAAAC
TAGCTTTACc
AGGTGAGT
TGGGGrI'GTT
TCAGCTCGTT
T'FITAcGACT
CTGCGAGAAG
TAGGAAAATG
GGTCTITT=
GCTAGGTTAC
CAITAGCTAc
ATCGTTGTTT
G'ITGATITAc TTT1'GTCGTG 9 *9 9 9**9 *999 9 *9 .9@9 9 INFORMATION FOR SEQ ID NO:42: SEQUENCE CHARACTERISTICS: LENGTH: 504 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (gerlomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .504 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:42 9.
9* ATGCTAAAAA AAATA'FITrr WI'TTTACGGG ATTTAATGAT TITTGTGGCTT TCAAATI'GCC CAAAGCTITI'- TACCGAGCTT GGGCTI'ATTT TrI'GTGGCGT TGGCTAACCA AACTCCTAGC AITGTAGCGA TCAATTITTG CTFI=rACAAT ACAAACACAG CATGArT=A GCCCTTTTGA
AACCAACAC
GGCCAATATC
TAATCTA'FrC
CATACGGAGT
TTI'ATTCATG
TTACGGCTTr
GTATCTTTTA
CTI'rTTTTGCC
TTTC
'ITAGGGATFI'
CTAGGGGCTG
AGGCGTATTT
TCCAITAAGG
TGGTGCITAT
GATGAAGAAA
TTGGTGTTTA
GCGCTTATGC
TATGCTCTAG
GGGTGTATAG
TTGCGGAGGG
GGGGTI'TTGC
TAGTAGCGCT
CGCTCAAACT
TCACCACTTTI
GCAAGCTTAC
GATI'TTTGGC
CGATATTTTC
CTCT'FrTTCT
GAGTITGGTG
CAATCCCTI'A
ATGCACCCCT
TTI'AGGCGCG
TCAATTTATG
INFORMATION FOR SEQ ID NO:43: SEQUENCE CHARACTERISTICS: LENGTH:, 459 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .459 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:43 a a a a *aa.
a.
a.
ATGAATTTAG
GTTTTAAAAA
ATTTTAATAG
CGCATCTTTA
TTGGTGCTAG
GAAAGAATTA
GCCTTGTTG
GCCAACGCTT
AAGTGGCTCT
ACCTAAAGCC
ATGTGGGGCA
ACGCTCCAAT
AAATTTTAAA
TCCAATTAGA
AAGAACTGAA
TTTATGAACG
AMAGGCGTIT
CCTAGATTTA
TAACCCCCAT
CGTTTTGATT
GTCTGTGGTT
AAAACTTAAA
AGAAAATGAA
CTATCCAAAG
GAAACCTAT
ATCGGCCGTT
AGCGCTAAAG
TATAATTGCT
AAAAkAGGTTT
GGGATTTTAG
AATTATFI'GG
AAGAGGGAT
TGCCATGCAA
GCGAGCTTTT
CCTTAAAAGA
ATCAAGATAA
TGATTI'AGA
AAACTTTAGG
TGTATGGCTC
TAAACAAGAA
AAGCCCTAAC
AGAAATCAAA
AGACGCTTTT
ATTGCATAAT
GTTAGAACAC
ATTTCTGGTA
a INFORMATION FOR SEQ ID NO:44: SEQUENCE CHARACTERISTICS: LENGTH: 177 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .177 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:44 ATGGCTATCG GG ITTCCGTT AGTGTGGG ATrTTACTCA CCCTrTTAG CCGTTC'ITAT TGGCGTGAGT TTGGGGGCGT TTCAGGGGTA TTATGGAGGG CTAGTGGATT TAGTGGGGCA AAGGTI'GAGC GAAATIGGA GCGCGATCCC CATGCITT1" TTACTCATrG TGATTTC INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 666 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc -feature LOCATION 1 .666 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:4S 0 00 00.
ATGAAGAAAA
GCGGTCTTTT
AAACAAAACC
ATAACCGCCT
GTGCGTTATG
GGCGAGGGCT
ATCATTTTCC
GCTAGCGGGA
GACAACCCCA
T1'GTCAATGT
ATTTTCATGT
TCCMAC
AAGCAAA-ACT
ETTTGTTGAG
ATAAGATTT
CAGGGAATGC
ACACCAAGAC
TGCTCGTTAA
CCITI'ATGT
AGGATCAAAA
TTGGCATGT
GGAATCCTA
CCACGAGCA
CTTrGGTGT
CGTATCAGAC
TGAAATCCTr GATCCTATrG TAA6AGAAGCG
AACCGATTAT
CCAAGACAGC
ATATAAGATT
CAATGCGACT
GXITrATGTC
TAAAAGAACT
TGTTTrAAAA
GCTAAAGAAA
GCGGATAAAG
AATTATGACG
TTATTAGAAG
GTGAAATTGA
GTGAGCGGGA
AAAAACATGA
TCAGGCTCAT
GGCGATATTC
ACCGGGTTTT
TGATTCGTTG
TCGCTATGCA
TGAGCGCCAA
TGTATATTCT
GCAATATTAA
GTTTGAACGA
TTTGGGTGAG
GCGCTTCAGG
TTAACATGCA
CTGTATTGTA
TATACCCTGA
GTTGTATTTG
ACGATTTGAC
AGACAATGTG
AGCGGRTAAG
GGTTTATAGG
AAAATATGAG
CGCGGATATT
GTGCAGCATT
AAAATCGCAT
TTTGCCCTAT
GTTI'GGCACT
120 180 240 300 360 420 480 540 600 660 INFORMATION FOR SEQ ID NO:46: SEQUENCE
CHARACTERISTICS:
LENGTH: 159 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .159 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:46 ATGCTGGATT TTGA GGT TCTTTTGGC
GCGACTGGG
TTGTTCGC TFTTATGAAAT TTATATTFrCA T1'TATGGTTr TCGCATCGGG GCGTAAGGAG CTATCCAATG AAGAGTTr INFORMATION FOR SEQ ID NO:47: SEQUENCE
CHARACTERISTICS:
LENGTH: 327 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular ATTTAGCCAT
GCGAA.AGCTC
TAAAAACGAT TCTAGGATTA (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...327 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:47 ATGCAAGATT TACCCCCATG CCCTAAACGC AACGACGCCT ACACCTACCA TGATGGCACG CAGTTCGTTT GCTCTAGCTG TTTGTATGAA TGGAATGGAA ATGAAATTAG TAATGAAGAA 120 TTGATCGTTA AAGATTGCCA TAATAATCTT TTACAAAATG GGGACTCGGT CATTCTCATT 180 AAAGATTTAA AGGTTAAAGG CTCATCTTTG GTGCTTAAAA AAGGCACTAA AATCAAAAAT 240 ATCAAGCTTG TCAATAGCGA TCACAATGTG GATTGTAAAG TGGAAGGGCA GAGCTTGTCT 300 TTAAAATCTG AATTCCTTAA AAAAGCT 327 INFORMATION FOR SEQ ID NO:48: SEQUENCE CHARACTERISTICS: LENGTH: 219 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...219 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:48 GTGGATGGGG CTATCATAAC AGGGAATTAT GCCTTGCAAG CAAAACTCAC CGGAGCCTTA TTTTCAGAAG ATAAGGACTC GCCTTATGCT AATCTTGTAG CCTCTCGTGA GGATAATGCG 120 CAAGATGAAG CGATAAAAGC GTTGATTGAA GCCTTACAGA GCGAAAAGAC CAGGAAATTC 180 ATTTTGGATA CCTATAAGGG GGCGATTATC CCGGCTTTT 219 INFORMATION FOR SEQ ID NO:49: SEQUENCE CHARACTERISTICS: LENGTH: 711 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc feature LOCATION .711 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:49
GTGTTI'YCCA
GAAGGGGTGG
AATAACGCTT
GGGATTATT
CTCAATAACG
ATGGGGAAGA
ACCCCTGTAT
ATCAGAGCCA
GGAGCGTTTG
ATCGTGGSYT
GGC'ITATGCG
CTTAGGCTCA
TGCTGGTGTT
GGCTATGCTC
CTATI'GAAGC
TGATCTrTG
CCGATTATIC
GTGCTCAATT
CCGCTCTCAT
ATCCTI'TGTA
TGGCTCTTTT
A'ITCCACGCT
ATCGCGCT
GGCAATGTCA
GGTGTFTGAGC
TTACTTGCTC
C'ITTGTGATG
GAATTTTGGC
CATGCTCTTT
CCCTATGCAC
CCATGCARCG
TAGTGCGGTG
TGGAGCGAGC
TI'CTCAATTA
TCCACCTCTT
TGCATGCGAT
GATAATTTTT
ATTGGCT1TTT
AATCGAATCA
ACCCTCCAGT
TACATTAGCG
ACATGGTTAG
ACGATGGTAA
TTI'GAAGTGG
ATGGCTAG
GGGCTATATG
TACGCATGCG
GGAAGACAAT
TAGGGCTTTT
GGTATCATAA
CGGATTTAGG
ATAAAGAAGT
TGrrTCTTT
CCAACGCTAT
CCOCTGGGGT
GTTATTTTAT
TCAATAAGGA
TTTGTAGCGG
TTCTTCAAAT
CTGGATATTA
CATTGGCTGG
AAAA.AGCGCG
CATGCTCATG
CTTTAGCATG
TATTGGCGCT
GGAGGGGCCT
GTATCTAATC
CGCATGCTTA
TTTAAAACGC
CCGGGCTTGG
CCCTCCTTTT
C
120 180 240 300 360 420 480 540 600 660 711 INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 291 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .291 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:SO -0
ATGATGATAA
CTTTCGGCGT
GCGAAAAGCT
GTGGTGTCTC
TTATTGCTT
CCAAACAATC
'rTATITTTAA
TGAAATGGA
TTGGCTCATT
TTCITTTCGC
GTATCAAAGA
CACCACGGAG
GAGCGCAACA
GCCCTTGATG
TCITTATT
TTCGCTAA
TITTGTCCCTG
GTGGGGCTTA
CTGCTI'AGCG
TTCAGCCATA
TGCGGGTTT
TI'GCACTTCT
TGATCACTGC
CTAAAATTGA
TCCTTTCGCG
TGTGTTTTCG
GTCAGACATT
TTATGCATGG
AAGGAA.ACGC
T
INFORMATION FOR SEQ ID NO:51: SEQUENCE CHARACTERISTICS: LENGTH: 840 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .840 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:51
ATGAAACTGA
TGCAGTAACT
AATGAACTGA
TTCATGGTGC
GTACTAACTT
AAGATCCTCC
TACTTGCAAC
AATCCCAACA
CTAGGAGCTA
GTGATCAATG
ACTCTCTTGC
TTAGAAACAT
ATTITTTAAGA
CAAGAAGAAA
GAGCAAGTGT
ATGCGAAAAA
TAGAGAAGTA
AAGTGAAGT'
TCAAACTTGT
AATACAAGAA
CCACTTTGAA
ACAAAGAAAA
ACACAAAAAA
AAGTGGCAAG
A.AGACAAGGA
TGAGTAATCG
ATGGCAACTT
GAGAGAATGA
TTTAATCGGT
AGTGGTGAAA
TAGTGAGATC
GCCAAATTAC
TCACCAI'CT
TTACTTCCAA
TCAAAAGGGT
ACCACAGACC
CTTGCATGGC
AGAAAAAGCT
ACAAGAATAT
TGCAGGTTAT
GAACATGCAA
ATACTIG CC
GTGGCAATTC
CAAAAGAACC
CCCTTAAATG
AAGGACTATT
AAAAAGATTA
GCTAACGGGG
GTGGTGATGA
TFI'GATGTGT
TATGATGTGA
CAGCTAGAAA
ACCACTAGGA
CAAATGAGGC
GCCAAAGAAG
AATCAAATCA
TGTGCTTAAT
ATGTTTATAC
ACAAACTCAA
TGTTGGATAA
CGCTCATAGG
CAAGATCTGA
TAGCGAGTAA
TGCAAGGAAG
GTGGAGCAAA
AAATCAATCA
AAAATAACCA
AGAATGTGAT
AAGAAGTTAG
GAAGTTTGCT
TTTAAGTGCG
GCCTGTGTAT
AGACACACCA
TAAACAAGT
CGATGCCAAT
CATTGAFTT
CTACAATGAT
TCAGCCAATG
CAACAAGCAA
GTATTACAAG
ACGAGAAATT
TAGTTCTGAG
GGAGAAGCTA
CAGTGGTAAG
120 180 240 300 360 420 480 540 600 660 720 780 840 p.
p p p p INFORMATION FOR SEQ ID NO:52: SEQUENCE CHARACTERISTICS: LENGTH: 174 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .174 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:52 ATGTGG1'TAG, ATCACATCGC TAAAGAGATC AGAAGTI'TAG TGGAAAACGA TATTGAAGTG GGTAITGTGA TTGGTGGAGG CAXTATCATT AGGGGGGTTA GCGCGGCTCT AGGGGGGATC ATI'AGGCGCA CCAGTGGGGA TTATATGGGC ATGTTAGCCA CCGTGAFTAW GCGG INFORMATION FOR SEQ ID NO:53: SEQUENCE CHARACTERISTICS: LENGTH: 372 base pairs TYPE:. nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .372 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:53
GTGCATAACT
GAAGAAATTT
TTAGGACACC
GAAACTAAAA
CACCTAGAAA
ACCGTAACTT
GCCCATTTAG
TCCATTGGAA
ATGAAGGGT'
AC CCC CTAGT
CGAGCTTCCA
AAGAATTTAA
ATGCGGACGA
CT
TGTGAAAGGC
TGCGGACATG
CACTI'TATCC
CTCTAAAGAC
AGAGCTCTCT
TCAATTAGCC
ACCGATTTT
TTTGATGATC
GAAGCGATCA
ATCTTTAAAG
AACACCGCCG
AAGTTGCAAA
TCAATGTGCA
TCGCTGAAAG
AACTCACTCG
AAATTCTAGA
AAAAAGAAGG
AATCCATTTG
TAAAGCCACT
GATCGTTCAA
TGTTAAAGAA
GGACTACAAA
CGATAAAGTr
GATGCTAGAA
INFORMATION FOR SEQ ID NO:54: SEQUENCE CHARACTERISTICS: LENGTH: 270 base pairs TYPE: nucleic acid STRANOEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .27C (xi) SEQUENCE DESCRIPT.::::: SEQ ID NO:54
ATGAATAAAA
AAAGTGATCG
TACGATATAG
GACTGCGCGA
AGCGTGGAA.A
CCATAAAAGC
CAAGCGGGGT
CGCTCITTTC
TACCTGAAGA
ATAACGCGCA
CG=ZZA GCCTATAACA GSDZAA7DGCTAAAAGGA TAAZ ZZA7TZ CTGGTGGAFI' A=7AD-AA AGCGTGGTGC
TGGGGCAAGA
TCATI'CAAAA
CGCTCTI'AA.A
AAGTGT'FIT
TCATGCCCCA
AGCTAAGGAA
GGTGGAAITA
ATGGCTCAAC
INFORMATION FOR SEQ ID SEQUENCE CHARACTERI1--iCS: LENGTH: 633 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1 633 (xi) SEQUENCE DESCRIPTION: SEQ ID
ATGGGGAAAA
CTTTTAGCTT
TTGCAAAAAG
GGCATTCAAG
GCCCTAAACT
GAAGGGTTTTI
ATTGATGCGA
ATTCAAAATG
AGCGCTAT
CTGTCTTTGC
AAAACCTT'G
TTTCAGCGCA
CGGTGTTATT
CITTTATGGCG
CCAACCGCAC
GCTACACTTA
TTGACTT1'GA
TTGAAGCCTT
AATTI'ATTGT
TTGAGCCT
AAGTCGTTAA
AAATTAAGAT
TTTAGCCCAT
AAAGCATGCG
CGTAGAAAGG
CAAGCAAAGT
CTCTAAAGAC
TTTAATGGGG
AGAAGAGAGC
CTTCACCATT
TGAAACCACT
AGCCCATGAA
TCTTAACGCT
GAAATCAGAA
AACGAAAAAA
ATCATTAAAG
TTGAAAACGC
ATTGATTTTC
ATTGTG'FrAC
GAACAAGGTC
ATTGATAATG
AAATTAAAGG
GGGAGCAITG
TCT
ACCCCGTAGG
CTAAACCCAT
CCACCTTGCT
TAGAGAGCGA
TTTTTAATTT
AAAATTTCTT
AGGTCAAAAT
GCAAGGAAGT
GGAATGGCTT
CGCTATTAGA
CTCTATCTCT
TGTTGTAGAA
TFI'TTCTAAA
TCTCAAAGAA
TAGCGATGAA
GTATAACGCC
TGAAGCGTTC
GGAAAATAAA
AGGGTTAGCC
AXATCAAGAA
0 .*0 *6 0. INFORMATION FOR SEQ ID NO:56: SEQUENCE CHARACTERISTICS: LENGTH: 636 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylor.
(ix) FEATURE: NAME/KEY: misc-feature LOCATION .636 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:56
GTGTCAGAAT
GCCTTATI'GC
ACAGCGGCCT
CCTGTTAGCA
GCTI'GGATCA
GAAATCTTAA
AT'GGCTr
ATCACAGCGG
'ITGATCGCTA
GCGAGCGCGG
TT71GTGAGCT
TI'CATCAAGT
CGATTTTGTT
TI'ITGAGCGT
TGGTGGG ITC
TTAI'GCCGC
AAGAAAGCGT
GT'TI'GGCTC
CGATI'AGT
ACACCGCTCC
TAGGGGTGCC
TGTTAGTCCC
TTATGACCCT
ATTTTTCTTA
GGCCTTATCA
AAGC'ICCTT
GATI~TTTTA
TCAGTCCATC
ATTITAGAA
GGGGTTGGGG
TGTGGCCTT
AGCGATCTTA
GTTITTATT
TTGGGTAATA
TCTTTAATGG
GCCA ITATI'G
TATGGCTTTC
TACAAACTCA
ACTTTAGATC
GGGGCGATCG
TTAAGCCCTT
GGCGCGGTGG
ATTTCAGCCA
GTGTKT
TFI'GGCTGAG
TTIAAACT
CGGTTITrAGT FTrATGGCCT
GCGTTAAATC
ACCGCATT
GCTTTGGAGG
TGTATTCTGC
GTATCCCTAT
TGACGGGTAA
CGCTCTTGTG
CAAAGGITAT
GTATAAAATG
ATGGCTATTC
CGGCTAFTI'
AGTGATTTTG
GCCTATTGCC
TGGGTTATGT
AAGCGCGATG
AATCCTCTTT
120 180 240 300 360 420 480 540 600 636 INFORMATION FOR SEQ ID NO:57: SEQUENCE CHARACTERISTICS: LENGTH: S46 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .546 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:57 a a a a. a a
ATGGAAATTA
ATCGCTGAAA
ATCAATCGTT
AAAAATAAGA
AAAAATAAGG
ATTGTGGAAT
CCTGAAGTCA
GAAGAATTGC
GCAAACCCCA
A I TT I
AAATGGCTAA
AAAATCAAAA
TGGAAAAAAA
GCGTGATCAT
GGGTTAAAAT
CCATGAGTAA
AGGGCGTGAT
AAGAAAAAAA
AAACTCTTGC
GGATTATGGT
CAGCTTGATT
TTTCAATGTG
AAGAACCCAT
CACTGACGCG
AGAAGGGTAT
CAGCTATGCC
ATTGCAACGG
AAATCGCTTC
TTTGTTTT G
TTGGCTCGC
AAAATTGAAG
GGCATTCCTA
ACTTGCCCGT
CAAATCGTGC
ACTAACCAGG
AAAGTGGCTT
TTATI'TGGTG
GCGTCAAAAG
TCATTCATAA
AAGATCCTAA
AACAGGATTr
ATGTGATCAA
?I'TITGGGGA
CTITAGTCGG
TAGTCTCTCA
GARGRTGCAC
AGCGATACAA
CGCTAAAGAA
AAAAATCCCT
AGAATAC ETG
ACCTCAGCAA
CATIAACCAC
CAATTCGTTA
AACCACCCAA
TGAAGTGCGT
a.
a a a INFORMATION FOR SEQ ID NO:58: SEQUENCE CHARACTERISTICS: LENGTH: 672 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .672 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:S8 ATGGATCATG AGTT =GAT C'ITATITrAC TCCCTATAGG TTAACGAGCT TAACAGAAAC GGGITTTATC TTCIT =TAAT GTGTTAAATG TGAAACTCGT TCCTI'GCCCT TTATGGTAAG AAAGAAGCCA GTI'ATAGCTr CCTAACATCA AACCCAGTGT GAATITGGCG TGGTGATGAT ATTACGATCT TTAACGAAGC ACGCTCACGC TTATTAGTIT AGCTCGTFI'T TA
TACCATGCGT
GAT'TTI'TA
GCTTGTGTAT
CTITTCGCCT
'TTTAGTrTC
CCCTATTAAA
GGGTAAAGGG
GTTGATGGCT
GCTI'GGGGGT
TGAAGCACTC
TAGCCTCTTG
TTGAGC ITl
GGCTATTT
ATGCCTITAG
TCTI'CTT
CAAGGGCITA
AGCGCGTTAA
GAATACTACA
ATCA ITACAA
GATATATTAG
AATTATTCTA
TTTGTTACCC
C TI'AGCTFI'
TAAGCCTTAA
TrI'TACCCCC
TGGGAGCGTT
TCTTAGGGAG
TFCCTTGCC
CCCTTTTr
CTTTTATGCA
GGGAAACAAG
AAGCCCATCA
TATFTTAAA
GAI'IACCACC
ACGCAATCTT
AAGCGTGCTA
I=ACAAGAT
CGTGATITI
CACTTCITIA
TGTCCTACTC
CACTATAGGT
AGTGGCTAGC
ATACGCCTTA
TAAAAAACAA
120 180 240 300 360 420 480 540 600 660 672 INFORMATION FOR SEQ ID NO:59: i)SEQUENCE CHARACTERISTICS: LENGTH: 420 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 420 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:S9 S. S S S S
*SSS
ATGCATCCTA
GGAACACTTT
GCAAZAGAGTI'
GAATTAATAG
GACATGAGAG
GAAATTGATT
ATAGAAAAAT
TAATGTTTGC
GCATGGCGTT
TGATAGGCAA
AATGTGGCGT
CCAGACAAGT
TAAAAAAGAT
CCTCAATGAT
CTATATCGCT
TCAAAA.AATA
CCTITCTCAA.
CCCATTAAGC
GCTAGTAAAA
TTGCAAGAAC
CTTAAAAAAG
AACGCGCTCG
TCTCAAGTCA
GATAGTGA.AA
AATATCGTTA
TACTI'ATAT
CAAACCAAGA
CTCAAGCTAG
AAGAATTAGG
ACCCCACAAA
TCAATTTCTT
CAAACGCTTC
TCTTGATAGC
AACTTATAAG
AAAGATCAAC
CATTGATAAA
AGATACTGAT
ACACAACACG
AGCTTTTATT
AATGCTGGTA
GAAGAGTATT
120 180 240 300 360 420
S.
S
INFORMATION FOR SEQ ID i)SEQUENCE CHARACTERISTICS: LENGTH: 219 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (aenomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Fel.=czbacter pyloni (ix) FEATURE: NAME/KEY: :eature LOCATION 1 (xi) SEQUENCE DESCRIPTION: SEQ ID ATGTGCCTGA CAGGCGGCTT GATGCGITGG CTCAAATCGG TAAAGCCTGA ACGAATC'ITG CAITCTGTGG TGGAATTTGT GGATATTGCC GGATTGATTA AGGGGCGAG CAAGGGGGAG GGTTTAGGCA ATCAGTITT AGCCAATATC AAGGAATGCG AAGTGATCTI' GCAAGTGGTG CGCTGTTFTG AAGATGACAA TYATCACGCA TGTGAACGA INFORMATION FOR SEQ ID NO:61: SEQUENCE CHARACTERISTICS: LENGTH: 276 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .276 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:61 a. a.
a a a.
a. a a a. a a.
a a
ATGCATGTTG
GAAATCGCTT
ATCGCCAAGC
CCTGCTTTTT
F1'ATTAAAGC
CTTGTCTTTT
CCAAACAGCA
TI'TAGAATG
ATGACCTTAA
AATTAAAAAA
GGCTITTAGGG GATAACCTCA ACAGTCCCIT AAAATCCTAG CGAAAAACAT TTI'GAAATCA AAAACAAGGC GTTTTTrTGGG CATCAAATCA AACGTT
TCACGCTTAG
GCACTCATTT
TTCCTGTITT
CGATGAAGGA
CCTTTTAAAA
GACTTTAAAA
TGAAAATATC
TTTITATGG
120 180 240 276 INFORMATION FOR SEQ ID NO:62: SEQUENCE CHARACTERISTICS: LENGTH: 615 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .615 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:62
ATGAAAAAGA
AAGAGAGAGA.
F1CACACACA
GACGAAGAAT
TTITCATTTA
AAAAAATGCC
GTTAAGATTC
GCATCAGGCG
ATCGCACCCA
GATAAATCTG
GGGGAGGACT
AGCCATTGAT
GAGAGTTATT
CTCAAGCCGA
GGGGGTTTAA
GGGGGTTGAA
ITTTCAGACGC
AAGAAAGAAA
CTGCAGGAGT
TTCAAGCAGG
TGGGCGCGAG
CTCGT
GTGGCGTATC
A.AGCTTCGCT
AGCCGGCGAT
AGGTTTTGTC
AGTCCCTGTT
TGAAAAAAAT
ACAGGCTATG
TGCTGGGCTI'
GATGATCTAT
TTTGGTCGCA
TGTGCGTTAA
AAACATTGGA
GCGTTTGTCC
AGAGCCTATG
GAAGGTI'TAG
AAGAAAAGGC
ATAGAGGAAT
ATCCCCATAC
AAAATGAATG
GGAGACTTCT
ATATCCCAAC
AAGAAACTAA
TGAGGGTCAA
AAGAAT1'GGT
ATTTCTTGAG
GTAAAACCAT
CITTI'AGCGA
ACGCTTTTrGG
TCTAGGGTTC
GATGTCG?22
AGGGATCATA
TI'CCGTTGCC
AGATGAAACC
TATTCAAAGA
TATCCATGTr
TGCGCTCGCT
AATGGATTTG
TCGCGCAAGT
120 180 240 300 360 420 480 540 600 615 GGATTGI'AG GCGTAAACTG INFORMATION FOR SEQ ID NO:63: SEQUENCE CHARACTERISTICS: LENGTH: 123 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .123 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:63 GTGCTTGGCG TGTTYAATTT AAGGGGCAAT GTCTTCCCTT TGATCAGTTT GCGTTTAAAG TTTGGC'FTGA AAGCCGAAAA ACAAAACAAiA GACACTCGTT ATTTGGTGGT ACGCCATAAC
GAT
INFORMATION FOR SEQ ID NO:64: SEQUENCE CHARACTERISTICS: LENGTH: 657 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .657 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:64 120 123 too*
GTGAAAAGCG
T1'GATCGCTT
ACCATTATAG
GTGGrI77 ITG
TITI'ATCAAA
ATCGCTAGCG
TTTTGCAG
GTGI'GGDA
GAAGTCTITC
AAGGGGGI'A
TGCTATF1'AG
TITTTAGCGA
ATGACCCCCT
GGGTITATGA.
GGCATAAAAT
ACAAGTTTCA
GAGGCAATCA
AAAATITACCG
AAAAGGGCGG
CTTTAGCCT
AAAAGCGTIT
CCAGCCCGCA
AGAAAAAGAA
AGATGGGAGT
AAAGGATTAT
AGAKATTGGTG
FTTTATAGAA
AAAGGATITT
CTTGCGATAC
AATGTITTCC
GATGGTTGAA
GCTAGATCAA
TGAAGCTCAG
ACGCCTGTTA
TCAGTGATGG
AAGGCGCAAA
GTGGCTrAG
ACCATCGTTT
TCYTTGGGCT
TCAGGATCTA
TACCCGCAAA
AAAGCTAAAG
AGCGTAGAAA
ATITTTAGAAA
CTAAAGAAAA
AGGCGAATTTr ATTTAGTrGC AAGAAGTrTA
TAGAAAATAA
TAAAAAAGGC
TGGTGGCTGA
AGAAAITGCG
GGGAAGCGT
GCTACCATGA
AACXTTAAA
CGGCTCTTAT
CTTAGTAGGC
AAGCCTrTAT
TCGTI'ACGCT
GGGTAAAATC
TTAGAAGGG
TGTCCATCAT
AAAGCI~
TrATTTrGAT
AAAAAGCGAA
GGGAGAA
120 180 240 300 360 420 480 540 600 657 INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 564 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) M4OLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .564 (xi) SEQUENCE DESCRIPTION: SEQ ID 4*4*
S
9*
S
.4 .s St 5 4
ATGAAAAGCA
GCGTTATGCT
GCGATAAAA
TTCAGGTTGG
TTATCTCAAA
GACGCCAAAA
AAAATCAAAG
AATTI'ACAAA
CTCACGCTTA
AAGAAAAACA
TTGGAGAAGT
C LTTGGAAAA
AGGAAATCCG
GCGTTI'CTGT
TTCAAAAACT
AATTGAGAGG
AAAATGAAAA
TCGCGCCCCA
TTI'GTATI'CC
AGAAAAGAAA
GATGGCGATA
CAAITGGCTA
CCGGCCCAAT
GGATGAAGTG
AGTCAAAGCA
GCTTAAAAAT
'FTrAGAGGTC
TITI'GAAGAA
ACCTATGCCC
ATCC
GGGGGCAATT
GGGTTTGAAT
CCCAAACGCT
ITTGAA ETAT
GAAGAGGGCA
TTAGGCTITTA
AGCCCTITTG
GTGGACACTT
CTAACCCTIT
TCTTAGAAGC
CGTTAAGCAA
TGCTCTATAT
GCCAGATTGA
TCAATTCTAG
GCGATGCCAG
AAGTGGAATT
GCGCGGCGGA
GCCCCCTATT
CTTACAAAAA
AGATTITAGAG
TGCTGATGCG
CAGGTGGTTT
CGTFF1'AACG
GATTGCCACT
AGCTAGATCT
GTT1'TTATCG
GGAAACAAAC
120 180 240 300 360 420 480 540 564
S
5*S* i.
S S 055 4 INFORMATION FOR SEQ ID NO:66: SEQUENCE CHARACTERISTICS: LENGTH: 693 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: (A NAME/KEY: misc_feature LOCATION 1.7..693 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:66
ATGTTTGGGA
TTAAAAAAAG
GTAGGTATTA
TTAGAAGAAC
TCTTATI'CTr
ACAGGGGGTG
AAAGAGGGCT
CTCTTGAATG
AAAACGGGTC
ATAAGCAGTT
AAGTCAATCT
AAAACAATAA
AAAGCGTTCA
TGAAAAGCCA
TGGGGGAATA
TAGAGAACGC
CGGCTAAAAA
AAGACATrGA,
ACAGCTTCAA
CTATCAAAGC
AGTCGTTT
ITI'TAAAGAA
AAATATTGAC
CCATAAAAAT
GCAAGAAAGC
TGGCGAAGAG
ATCGCTFI'AT
ATCAGTCAAA
CTTTAAATT
AAAAGCGGGA
AACGCAGAAA
GGCGTGCAGT
GATTTGT1TA
ATGCAGTATT
CATICTAATG
GAAAAGATGC
AAGATI'CTGA
TGTGCTTGCA
ATCFI'GCAAG
GCGTI'AATT
ATTrrI'CATT
AGACT'TI'TG
TCCATCAAGA
AAGGATI'AAT
AAAACGCCAC
GATI'GCGGAG
TGAGGG79F1IT
CITAAACAAT
ACAAGGGGTI'
GGCTAAAAAA
CACGAGC~TTA
AACAGGCTTG
AACCGTTAAT
TTCGTTAGCG
120 180 240 300 360 420 480 540 GACTCCCTCA ACCAACGGAG CAATGAAATC ACTCAAGTCA TTTCTFI'GAT TGATGATATT GCAGAGCAAA CCAATCTCTT AGCCCTAAAC GCCGCTATTG AGGCCGCACG AGCGGTGAAC ATGGCAGAGG GTTTGCGGTG GTGGCTGATG AGO INFORMATION FOR SEQ ID NO:67: SEQUENCE CHARACTERISTICS: LENGTH: 189 base pairs iB) TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni
FEATURE:
NAME/KEY: misc-feature LOCATION .189 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:67 ATGTGGA'rTA TGTCTTCACT TTCTAGTTCA TTCFITCATT AACCCTGGCC AACTCTTAAA AGGTTGGGGT TCAAAAATCT GTI'TTAGCAC AG-TATAATCC TAGCGTTTCA ATTTrATTT
GTTGGCGTT
INFORMATION FOR SEQ ID NO:68: SEQUENCE CHARACTERISTICS: LENGTH: 459 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1.7.459 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:68 CGCTCTTCTT CATCAAATCA TTTrCATAAA TAGAAAGmT TACTCAATAG GGTGTTTGGT
GTGCGCTA
GAGAAAGGGA
CTCAATGACG
AA'TTGGACA
TITTATI'CTC
CCAAATGATC
GCTCTCAAAG
AACATCAAAA
ACCCTGTGCC
TCAAATTAGT
GCTCTTTAGA
GAAAAATGCA
AAAAAATCAC
CGGCCAATCA
ACCCAAGCAA
TCAAACCCCT
GCATGCGCAA
GATCGTGTCT
CGCGAA'ITAC
CCTTGTTGGT
AGACATTAAA
AGGCAGGGCG
TCTATACGCT
AGAAGCTGCG
ATCTrGCAAT
TTTACGGATT
'ITCCAGCACC
TTGGCCAATA
AACCTTAAAA
'ITGATITTTAC
ACGGAGTTTG
GTTAT'GCC
CAGTTGTGGA
ATGTGTrGCC GCCCT'AT1'
TCCATGTGGA
AAGGCTCAGT
TCCATAAACA
ATATTGTCAA
TGATTI'GAAA
TAAI'TAGCG
GGATCGGTT
GCCTTTAAGA
GATTGCTGTG
AGGCCTTATC
AAATCCTTAC
120 180 240 300 360 420 459 INFORMATION FOR SEQ ID NO:69: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 216 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc feature LOCATION .216 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:69 ATGGGGCTI'G TTGCGAGCGG CATTAACGAT GAAGAGCT GGGTTAAAA TGGGTCTITG TTTTCAAGTG CTAGATGATA GAAAAAGAAA GCGGTAAAAC CACGCATTTA GACAGCGCTA TTGGGGCTAA AAAAGGCAGC GGTTACGCCC AAACTT INFORMATION FOR SEQ ID Ci) SEQUENCE CHARACTERISTICS: LENGTH: 627 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geriomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: CA) ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 627 (xi) SEQUENCE DESCRIPTION: SEQ ID TAAAATGGCT TCAGGCTT TTATAGACGT TACACAAGAT AAAACAGCTT TGTGAA TTI'A 120 180 216
ATGGGGTTA
CGCCCGAGCG
GCTCTITTGT
CCT'TI'TAA
'FITGTCGTGG
GATATTCCTT
GATTTGCTCT
CCTAGCCAAT
CTGATCTGCT
TTAGGGGTT
AACATTICCTA
ACCGCTTGGT
TGGATGGTAG
TCGTGGGAGT
TCATI'TTAGG
G'TrGGCTTT
TATGGAATGT
ATI'CTTTACA
TAGGGGAAAA
GGCTTTGTT
CAGCCTTGAT
AAAGCCTT
GGATAGAGAC
GATCAGCGTI'
GAGTTA'TrC GGG ITATTCG
GGGTTIAGCC
CTTITTGGCY
GGATATGGAG
ATGGTGCTTG
TGTGAAATGC
CTTACTCTAT
TTGTGAG
ATGATAAGG
AAAGGCATGG
ATCAACCCTT
TATTTCAAGC
CCCATTGCAG
TTAGGGGTGA
T1'GATAAAG AATCT'rTCAA
TATCATGGGG
GAGCAGATT
ATAACCCAAG
TCATFI'TAG
TAGCTITCAA.
GC TTcr'c
GAAGCGTGG;C
TGTTGTGGGT
AAAGGGGCTl'
GGCTCTCGCA
GGCTTTTTGC
TAGTGGCCAG
GACGAAAAAC
CGTTTCAAAC
GCTTTCGTTA
TTGGCGCAT
GGTI'TAGGG
GGCTGGGTT
GTITICCAITT
CCTTGTGGCA.
GTATTTGGGC
AGATI'ATAAA
INFORMATION FOR SEQ ID NO:71: SEQUENCE CHARACTERISTICS: LENGTH: 285 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .285 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:7l
GTGGAGCAAA
ACATTGATIG
TACGGGTATC
TTCAAAAAGA
TCTTTCTACA
ATAAAATCAT
GCACGATTWA
TI'ITTGCGCT
AAGGGTTGGT
CCGCATGGCA
TAAACTCTTC
TGGCATGAAT
GATI'GTCATG
TGTAGCCTTT
TAGTCTCCTT
ACTGTGGCGA
TTTAAATTCA
GCGATTTCTA
CATGGAATTT
GGCTACGCCA
CTATGGCGAT
TGCCGGAGTT
CGATTTTGCC
TTATCCTCAC
CGCTT
GATGCCC CCC
AGAATGGCAA
GGTGATTTAT
TCTI'AGACGC
INFORMATION FOR SEQ ID NO:72: SEQUENCE CHARACTERISTICS: LENGTH: 276 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .276 (xi) SEQUENCE DESCRfPTION: SEQ ID NO:72 a
ATGTTCGATT
GTTTGGA1TFI
TI'AAAGATTG
GACGCTCCAG
AATGAATTGT
CAATCGTTTA
CGCTrI'ATrT
AACTCAGGCG
AGCATITAT
TGCAGGSCTI'
ITTTCAAT
GGTGATGACT
CGAGATGCAA
GTI'TAATAAA
GGAAACACCA
AAGAGCGGGT
ITATGGGTCT
TCTrI'GTCTA
AAAAGAAATG
GGT1'CT
TTGTTACCAC
TITTGTATAA
ACATTCTTAA
ATGAGACCAA
GCTTG'FITrA
AAGCATTGTA
TGGAGCGCAA
AAGGTATTCT
INFORMATION FOR SEQ ID NO:73: SEQUENCE CHARACTERISTICS: LE.NGTH: 375 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FE-ATURE-: NAME/KEY: misc-feature LOCATION .375 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:73
ATGGCGATGC
GATATTGGCG
CITTI'AAAAA
GCGACCATCT
TI'GAGCCAAC
AAAATGGGGT
TATAAACAAA
TYTATTGCAT
AATGGTTCCC
TCGTGTI'GGA
T1'AGCGAAAT
TITTGGGTIT
TCATTGGCAA
AACTT
GCGGTTATTG
TGATAATGAC
TTTTTCTCAA
CCCTAAAATC
AGAAAAATCT
ACAAGAAGGG
ATGCCGATT
CCCAAATACA
AGCATTGGGT
ACTCCTTACA
CAAATCAGCT
CTGTTAGTCC
TAGGAGCGAT
AAAACGCCTC
TTGAATTGCT
AACCGGCGAT
TGAAAGCCAC
AAGCGCATGT
TAAAGGGGGG
TTCTAAAGAG
TGAAATGGGA
TT1'AGAGAAT
TACAATGGAA
GAGCATGCGT
S
INFORMATION FOR SEQ ID NO:74: SEQUENCE CHARACTERISTICS: LENGTH: 3534 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .3534 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:74
ATGATACCAA
CCACAAACCG
ATTAAAGTTG
AATGATAGGG
AATAAAGCGA
AGCAATGATI'
CAGAAATITG
CCGTCTAAAA
ATCTCTGATG
AITATCATAG
TTGAAAGAGA
GATTGGCTTG
GAAACGCTCA
ATTI'AGATAT
AAGCGGCTT
ATAATGTTGT
ATAATAGGCA
TCAAAAATCC
TAATCGACAA
GGACTCAGCG
TCAACACCCA
ATAAAGAGAA
GAAACCAAAT
GGCAAGAAGC
ATATTTTT
ATC.AAGAACC
AGAAGGAGAA
TAACCCGCAG
CGCTTCA TI'
AGCTTITGAG
TACCAAAAAG
AGACAATCTC
TTACCAAATr
AAAAATCCGA
AGCGGAGTT
CCGATCGGAT
AGAAAAAAAT
ATCAITI'GTG
AGTI'CCTCAT
ACAATGACTA
CAATTTATCA
GATCCTAATC
AAAATCTCGC
AATCAGTATT
ATTGATACAG
TTATGAATT
GG'TTTATGG
TTGAGGTCTG
CAAAAATTCA
GGAGAGCCTA
ACGAAGCCAT
ATAATCT'CA
AAAAACCAAT
AGCTAAGGGA
TTTCAAGCTT
GTTCTTCCAT
GGGTGTCCCA
AAAATATCAT
CCAAACAAGC
TGGGCGTGTI'
ATGGAGATCC
TAACCAACAA
AGTGGCTTI'
CG ETGATAAG
GGAATTCGCT
TATCAGTAAG
AAAGAGCTT
TCAAAACGAT
ACAACCCCCT
TTITGCAGGA
TGATGAATCT
TACTGGTGGG
CGATCTCAAA
TACCACCACT
120 180 240 300 360 420 480 540 600 660 720 780 TTTAACAAAA AACAATCTC GTCCAACCAG ATGTAGCCAC
GACATACAA
AAATTCACTC
AATTACAAGT
AGTCATAATG
GAAGCTAGGC
GCTACACTCA
AAAGGGATTA
CGAGCATTGA
AATAATGCTA
GAAGATTTTC
TTTGTTTCTA
TTGAGCTACA
AAAACCACTC
TTCAAATACA
TCCCATTTAG
CTCGCTATCA
TCCCCACAAG
GGAAAAGCTT
GAGCTGAAAC
AAAGATGTAG
TCTCAAGCTA
GATGCAAGAG
AAACTTGAAA
AATGGCAAA
GTGAA-AGATT
TTGAATGAAT
GACCTTGAAA
AA.TCTCAATC
GCGTTAGCCG
GAAGATI'TCA
GGAACCCTAG
TCGGACATCA
GGACTCGAAA
ATTGACCGAC
CTTTTGAAAA
GAACCCATT
AAAGTTIGATG
GACAATCTCA
ATGATAGACA
GCAAAAAAAG
ACACCCATTA
ACGCAAAAA
GGAAGTGCTC
TAFI'CTGATT
GGCTTTGTGC
AGTGTGGAAC
GCTTACCCC
TLTGGCGATAT
TCA.ACCAATT
GCATAGAACC
ATGATT1GGAA
TTAATGTGCA.
ACAACCCTAG
GTCA.AGAAGA
AATTIAGACAA
AAAAAGACTC
AAAAAGACAA
CTCTCAAAGA
TTCAAGGTAG
CCAACGCCTC
AAGCAGGCTT
CTAGTGTCGT
AAGCTAATAA
TAAACTTCAA
AAGCTCAGAA
CGAAAAATTT
ACAGCCAA
CAATCGCTTA
ATATCAACAA
ATAAGGATI'
TAGGTATCAA
TCMJAAATGG
ATTCCATTAA
AAGCGGTATC
ATCTCAAAAA
ATACTGGAA
TCGGTAATGG
AGAAAGAGTT
ACAGCACAGA
TCGATCAAAT
GGCATGATAA
ACGCTACGAT
ATCTCAGTAA
ACCAGGCGGT
AGCTCAAAGA
TGCCTACTAG
ATAGCAATGT
ATITCTGAGTG
CTI'GTCAGC
CGTTCAAGTT
AA'FI=AAC
ATGGAGTCAA
TGAAGCTAGG
GAACATGTTA
ATTGATCCAC
TGAAAAAGTT
CGCCACCGTT
TATGAAAAAT
TTTITATCTC
GATCCAAAAC
CTTGAGCAAG
TAAGGCTTAT
AAAACAT'TA
TTATGGGAAA
CCTAAAACAT
CAAGAGTCCT
TAGCAAGGTA
AAGGCAGGAT
GCTIGTCAAA
TAAAGCTGTA
AGATCTTGAA
GGAGAGCAA.A
AGATGAGATI'
CGCTCAGAAT
GGATTTGAAA
CAGCAAGGCA
TCCAGAATGG
CAAAAATAAG
AGATGTGATC
AGTGGCTAAA
TTTCTCAAAG'
A.AATTCTGCA
GTTATCTAAA
GAATGCAAAA
ACCCATI'TAT
AGCAAGTGGT
AGF1'GATGAT
TGATGATCTC
GGTAGGGCTT
ATCAGAAGCT
TTCTACAAA
TITGTCAGCG
CAAAAATGGA
GCTCAAGCTC
GTATGATAA
TTCCACCAGG
CAATATATT'
AAATACTAAT
GXFFI'GCTTG
GATGTWGAGG_
AATAACGCTC
TCA'TGTGT
GGTTATAAAA
GGCAGTGGGT
TACAAAGAAG
AAAGTGGATT
AAAGAGAAAG
TTAGACGCCC
GCTTTAGTTG
AAAGCAGATA
GATGGCGTGA
GATAAGGGTG
GCTGTCTTTA
TTAGAGGATA
GATTITGA
GCTGAAGCTA
AAATCTCTAA
AGCGGCAACA
TTIGCGTTGA
CTTAAAGGCA
GACTITAGTA
GAAGAAACAC
ATTI'CAAAAG
GATCAGCA
ATCAATCAAA
GCAACGGGTG
GAGCAATTGG
CTATACCAAT
GCAGAAGCCA
CTTGGAAATT
ACTCAAGTTG
TIGGGTGATG
CTCAGTAAGG
GGCGGACCTt
TCAAGGGAGC
AAAGCAAGTC
AAGAATGTTG
AAATTGGACA
ACAATCAATG
GTGAATGATA
ATTGGATTCA
TTGAGCAATG
TCTATGGGAT
ACA.AAAGGTG
ATGAAAGGGG
GAGTCGCTGA
TGTCTTCTGT
ATGGAAACAA
ACCAACGAGG
TAGTCATAGC
ACCAACTCAC
TCATGGAATT
AAAAAFI'CCA
TAGGGAATGA
CTGAGTTTGG
AAGCTTTAGA
TGTTTGTTGA
TGGGTGCTAC
ATITGCCTAA
AACTAATCGC
GCAGCAACAA
AAAACACAGG
AGAAACGAGA
AAAATAAAAT
TCAATAXAGA
TCAAAAGGGA
AATCTITTGA
TAAAAGCCCT
TTGAAAACCT
AGGTAACGCA
AGATAACGGA
ATTITCAGTGG
CTCAACAAGC
CCGTTAAGAA
CAACTCTITC
TCAATAACAA
CTAAAAGGT
TAGGGCAAGC
TAGGGCTTTC
TCCCTTrGAA
AAAATTGAC
ATTTTGACAA
TGAATCTATA
A'FTACGCTAC
AAAAAGCGAC
AGATAGTTGC
ACCAAAAGAA
CCGTAAAAGA
CITACAGCTT
G'rTCCAA.AA
TAATI'FFTCT
CATTGATCCT
GTTAATGGGG
TGGTGGTCCT
CGACAATGTG
AGGTGGTGAG
AGGCTCACAA
TCTTGCACAA
AATGAGATT
TCACATTGCT
TAATGGGGAA.
TAGGGAGGCA
TI'ATI'CTAAT
GAATGGCGI'
T'ITAAATAAT
TAAAGGATTG
AGAATTGGTT
CAACTATGAC
GCGTTTGGAG
GGAAGCAAAA
GGCTAATAGG
ATTGTCTGAT
TGAATTCAAA
TAAAGGCTCG
TAATGCAGCT
AGCAAAAAGC
TAAAGTTGAT
GGTAGAGCAA
TCAAAAAAAT
TGGTGTAAAC
TAAAAACTTT
TAACAATAAT
AAAAGCAAAA
AGCGAGCTTC
AGCTAACCAT
AAGGCATGAT
TCAGAA.AATT
CCTAGATCAA
TGTI'GAAAGT
TAACAGCCAC
CGGCATGCTA
GCATAATGTG
TATGAAAGAT
CATTAAGTCT
GATGAAAGCA
ATCT
840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1800 1860 1920 1980 2040 2100 2160 2220 2280 2340 2400 2460 2520 2580 2640 2700 2760 2820 2880 2940 3000 3060 3120 3180 3240 3300 3360 3420 3480 3534
G
INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 1398 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: H-elicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .1398 (xi) SEQUENCE DESCRIPTION: SEQ ID
ATGAAAGCGT
AACCACTTAA
GCTAAXAGAG
ATCAAGCTCG
GTGAATGATG
AATCCCATGC
GAAAGGATCA
ATCTCTGAAA
AAAAACTTIAC
AAGGATTTTG
GGACTI'AGAG
GCTAAAAAA
ACGGCTTATG
GTGTATGCGA
GATAATGAGT
TGCAAGAAAG
CGCTTAAAAG
AAAGGTGAAG
GTAGAAACTG
ATGGTGCAAA
CCTOCTGACG
GAAATAGAGA
GGAAAGCCAA
CAGTCGTTTA
TGAAGACTT
ACGCTGTGGC
CATGGGATGA
CTCAAGACAC
TTITGAACAA
AGTATGTAGA
AAGAAAATGC
AATGCCCTGA
ACCAATTI'I
CTAACGCCAT
GCAGAGCCTT
TCCAXITATT
AAAAACTTAG
AAGTCAAACA
TGGGCGTTAA
AAAACAGAAA
CGCAAT TA
CAGCCGCTAA
CTI'TAGAAAT
TGCA.AAGCTA
CCCTAAAAGA
AAGTCTATAG
GTGGCGTGAA
ATCCGTAT
TTTAAAAAA
TATGAITGTG
AAGCAAGTGG
ATTAGATAGG
AACCAATCAA
AAAAATCCAA
ACAAAACTAT
ACTCAATTGG
CACGAGCAAG
AGGTAACACT
ATTAGAATAC
AGACAGCCAA
AGCTGAAAA
GCTTGTTGTA
AACTTTTGGG
TGGCAAAAGC
TGAGCTTAAT
AGTGTTCAAT
CGCTCAA.T
TGCATTCAAG
TGACAAAGAG
GGCTAA).TTA
TTCAAATAGT
TCCCTTATTC
GATAATCCTA
GCTAAACATT
GCTAATCAGA
TTTCTAACAG
AGITTTGCCA
GATATACGCA
GATGTCAGTC
GGGAAAGAAA
CAAATCAGCA
ATITGCAITC
ATGACTTTAG
GAAGAATTAA
GCTTCCCAAG
TTCAACGATG
GAGTGCATCC
TTAGATTATA
GACTACAAAC
TTAAGTTTTA
CAACAAATGG
CATCAAGAAA
GACGCTTATG
AATAATGAAG
TGTTACTAGC
CGCAGAACGC
TAGCCACTAT
CGCTTAAT'C
GCAGTArrrr
AGCAAGTI'CA
ATCAAATTGC
AAGACGCGAG
GCGCTAACAC
CGGCGAACGA
AAAA.AGGCAA
CTCTACTCAA
AAAGACA.AAT
ATAGAGCGTT
AGAATGTTAA
CTAACATGCT
GTAGGGATAT
ACCGATTCCA
TGAATAAGAC
GCTATTI'TGA
ATCTTGAACA
GTTTCCCTAA
CCCCAAGCTC
AATI'GCCTTA
TTGGAATGGT
TACTGAAAGG
CATCAACAA
AAGCATCCCC
AGCCAATACT
AGCCAAACGC
CCCTACAGAG
AAAGGCTCTA
TTTAGGAGCT
TTTAGAAGCG
TAACGACTAT
CGCTTCAAAT
TAGTCAAATG
AAAAGGTTAT
CAATGTTAAT
TGCTGGTAAA
ACAAFI'AAGC
GCTAGGTrI'A
AGATATTATT
AAAACAACAA
TGGTAGTGTA
TGATAATATC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1398
S
S.
*SS.
*5
*SS.
S
S
S S S S to INFORM~ATION FOR SEQ ID NO:76: SEQUENCE CHARACTERISTICS: LENGTH: 189 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1.-..189 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:76 GTGATGGATG CAGAAAATGG GGAATTGCTC GTTGCAGGAA GTI'ACCCTGA ATACAAITI'TG AACGXTrG TAG;GCGGGAT CAGTCAAGAC AAATGGCAA.A AACTCCAAGA TGATATTTAT AACCCTTI'AT TAAACCGCTI' CGCAATGCCT TGTATCCGCC GGGATCTGTG GT1'AAAATGG
GCGTGGGGT
INFORMATION FOR SEQ ID NO:77: SEQUENCE CHARACTERISTICS: LENGTH: 1263 base pairs TYPE: nucleic acid STRANDEDNESS: double iD) TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1263 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:77
S
S.
S
ATGAATT
AGTCTTGCTG
ACTATTTTAT
AAAACCGCTA
AAAAATCCTA
CTAGCCATAC
F1AAGTCCTA GTrAATCTGT
CCTAAAATAA
CTTATTATTG
GTATTGCCTT
CTCATrI'CCC
ATAATCTATA
GGCAATGCGG
GAAGGAGATTI
GTITI'AGGTT
ATCTTTGGCA.
ACAATAGGCG
GCCTATCAGA
CTTGGAGCAA.
GTGAAACACT
AAA
TTGACACCCT
AACATGTGGG
TTATGATATG
TGGGTGTGGT
ATGATTITAA
TTATCGCTCA
GTGAAATT
GGGATAATGC
TTATGTFT
TGTTATTAGT
TAGGTTTAAT
TTACTCTITA
AAGTCAATAC
ATAAAATGGC
GGAACTCTTA
CTGTGATTTG
CAAGTGGAGG
GAGCTGTATr
GTGCTGGGGG
TCAGTGGAGG
TTGTAGCAAG
TATGGGTATG
TAG CTFTTT
GGCGTATAAG
TGTATTTATA
CACTTATFI'T
AAGCCTAAAT
TACCATAGGA
TTITGATGGT
TTTAGTGATT
TACAGCAGAA
CCCCCAAACC
TAAACCTrGT
TITAATCCCC
AAATGAGGGA
TATAGCCCAT
TFI'CTTTCTA
CGTGGGGGCA
TGGGGGTAGT
CGGACTAGCA
GGCAAGTGCT
TGTTAAAAGT
TTIGTTGAGC
CATGCACAAC
CGTGTGAAAG
GCGTI'TGTAG
ATCAATACGA
GATGGCTI'AG
AATTAGCCT
ATTAACATGT
.TTAGGGGAAT
ATI'T1ATGT
AAAGGCATGT
ATGATGTTAG
ACTAAACACG
AAAATrATI'G
AGTTCTATTG
GTCAAACGAG
GTAACAGAAA
GCAGTTATGG
GGACTI'CAAG
ATGGCAAACC
CATCTCAAAA
TCATTTTAAA
AGGGCGATAT
GATTTATCAA
TATTCTACCC
AAkATCCCCAC
CAAGTGCGTA
TTAATTGGCT
TATTGT'F1TT
GGTCAGCATT
TATTTAGCTA
TAGCTTTT
AAGTCACACA
ATGTCTTTCG
TAGGCTTFF=
TGCCTGATTr
TGATGCAAAA
TI'GCTAATCA
CTGGAGCTAA
ACAGGAGTGT
AGTAGCCAAA
CACAATTATT
GTTTGAGTT
TTGGGGGATT
ATCTGAAAAA
TAACACTAAT
TGCAATGATA
CACAATGATA
AGGCITATTG
AGGTI'TAATT
TCTI'AAAAAG
TAATTATGGA
AGGCTI'TTAT
CAATGTCrrA
AACCATI'ATT
TATCAATAAT
AATI'GGCATG
AGTTAAGCAA
AGCTTTTGGG
TAAAGCTGGr,
TAAAAATAAT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1263 GGCTrTGGAT*TTGATAATGA INFORMATION FOR SEQ ID NO:78: SEQUENCE CHARACTERISTICS: LENGTH: 267 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .267 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:78
ATGGATGAAC
AGCTTGCGCA
GATAGTTGCG
AATTCTATAT
GACTTATTAG
CAGAAACCAG
ACACCCAACA
AATGGGTATT
TAAAATCTGT
CGTTACTAAA
TITTAGAGCAA AACGCTCTTA ACTTACAAGT ATCATCGCCA GCTCCTTAAG AATGGCAACA AGCTAAAACT TTTAACTTTA
GGATATT
TAAGACTATC
CTCATGATCC
TI'GCTCAATA
AAGAAAAACC
AAATCTCATA
TATTGTCTTA
CAAACCTTTA
AACCACAAAA
120 180 240 267 INFORMATION FOR SEQ ID NO:79: SEQUENCE CHARACTERISTICS: LENGTH: 711 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION l...711 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:79 *foe 00.
See.S S. 0
GTGAAAACCT
TITGTATTTT
TGGTCTGAAA
GGCATAGTGA
ATTTTATI'AA
GTGGGTIITrG
ATAGCTCCTG
TTGCCTGGCG
ATCGGTTT
GGGATTTACA
GGGCTTGGAG
CCCG FITTTC
TAGGAI'TGTC
TI'ACAAGTAT
TCAACACTTA
TGGCCCACTI'
TGGTAATCCC
GCGTGGATAG
TT77 T GT CT1'GGGTTTT
TAACCGCTTC
TGGTIITGA
GAA~TTTGG
AGCAAATGAA
TTCGCTTGGT
CAT1'GCCAAA
TGGGATCTT'
TGGGGATAAA
AACCTrGCG
CATGGGGCTT
RCITGITAGG
TGTCCATGAA
CGTAGTTTCT
CAAGCCTGT'
TATCATTTCT
GCAGGGACGA
GGGACITTAG
CACTITT.L7CC
GCTGCAGGTT
TTCGGTCGTA
CTAGCTITGA
ACCCCTAAAA
ATTTGTCAAG
CATGCCCCAC
GGGATITTTGC
GTTGAAGATT
GTGTATTTGA
TGCC'FrAGTC
AATTTTACGA
CAAACACGCT
ATCTGGCGCG
AAAACATGTT
TGCCAACTT
ACGCTCATTA
GCGTCGCTGT
AAGGACAAA
TTGGGAGTIT
GGGCTTGGCG
GGCGCTTTT
AAATTcccGc
T'ITTATCATC
TAGCCCTATC
CCCGC'FrGGT
CATGCTCTCT
TAATGATTTIG
TCTTGGITAC
GGGTGGTGA.A
AAACACTTAT
GGTTTATATC
GG'IWGCCTTT
AGAAGAAACT
T
S S 5 INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 1413 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1413 (xi) SEQUENCE DESCRIPTION: SEQ ID
ATGCGCAAAT
GATATTITG
ATI'GAGACTA
TCCAGAAAAT
AAAGAGTTTC
AACTTGGAGA
GTATCAGATA
GATGGTIATA
TTGTTTAAGC
GATAATTCTT
AAAAGCGTGT
AGTGTTGCGC
AAACATGAAA
GTTGCTTAT
TTTGTTGCGC
TATAAAACTA
GTAGAGGGCG
AAGCAAATCA
CGCCATTTAG
GAAGGAAATA
CAAAAAGCTT
TATGATTGCG
GATTTTATGG
GTTCCAATCT
TTI'TGGATGG
ATACCCTCCT
AATACAATAT
TAAGTAAAAG
ATTCATATALA
TGTTAGAACT
TGTATTTACC
CAAATTTCTA
ATGTTTIAAA
GGGCAGATGA
TGAAACAAT
AAAGTTI'AT
AATTTGATTA
GCCAGTITAT
GAGATGGI'A
CTTATGTCTA
AGAGTTI'GGA
CCACCAACCA
CGTAAAATG
TCGCTATI'GT
TAAATAAAGA
TGAGI=rCTT
AGTTTTTGCT
TATCAAAAAG
GGCAAAAAGT
TCTAAGACCT
TAAAGGTI'
ACAAGACATTI
GGGAGTAGAA
CTATCGTTTC
TTTAGAGGTI'
TCTTAGTAAC
ACAAGAAAAT
CGCTATGCCT
AGAGAAGTT
TTTAGGATCT
TTGGTITCT'
CTATAAGGAG
TI'TATTGCAA
TGCTCCCAGA
AATTTIGCGT
ACAGGCGTAT
TTAGATAAT
AGATACGATT
AGTIIrTTGGG
ACCTTITTTCA
AACAAGCCCT
ACGTTTCATC
GAGGTTTTAA
TTCAF1'AAAC
CATCAAGCAA
ACTCTAGATG
ATCGCTACTG
GCTAAAGAGA
CTTGAAGATA
CATATAATGC
ATTACTAATA
AAAAGTI'AG
TTICCTA.AAT
TTATGCG'TTT
TTAGGAGCGA
ATTCACAAAA
AAAATTTTTA
ATITTAAAAA
ATTTTAGAAG
GTATATCTCT
TACAGAAAAT
ACTTTAGGCT
TGCTATGTGG
CACCCTAAAC
GAATACCCTA
TTG
AATACGATGT
CCACAGATTT
GGATCCTGGC
AAAT'FrATCA
AAAAAGAGGT
ACAATAAGAG
TTTTAATT~C
TCACTAAACA
CGCAGATATT
GCATAGCAAC
ACAAAACATT
TTATAAAAA
TGCAGGCAGG
GAAATATTGA
ATATTTTATA
AAGCGGTATT
GCGAAGAAGA
ATAGCAATTT
ACTTGTTTTC
ATTCTTCGCA
ATCTCCTAAG
CCGFI'ATIT
T=TA6AATG-T
GATTTCTT
ATI'TTGTAT
AGAAATGCAA
TCAAATCCCA
GCTTGTTCCA
AGTGATTAT
TA.AGGGTITTT
TI'CAAAGGAT
GCATATCGGT
GCTAT LTAGA
TAATCCAACC
TI'ATATTCAA
AATTGCACCC
TACTTI'AGTG
TCCAAATTCA
TTTAGAAGTC
AGTTAAAAAG
TGAACXITGC
ATCAAATTTA
AGGGTFTAATC
AATTTTAAAT
TCATAATTGG
AGAAAATGGC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1413 9 *9 9 *0*9 *9.9 9 9 L9 *Q 99 9 9 9 *9 99 9 9999 99 09 9 INFORMATION FOR SEQ ID NO:81: SEQUENCE CHARACTERISTICS: LENGTH: 369 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .369 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:81 99 9 999 9
GTGTTGAAAT
GGGATTTI'GA
GGCAGTAAGG
ATTTTAATTC
AAAGACACGC
GGCGGGG-TTG
GGCGA'FFIC
TCTFI'GAAGA
TITI'CCAAGA
ATI'CTCATGT
TTTTATI'ATr
GCTGCCTGA
AGCCAITTI'T
TTCAAACAG
TATTGCAGCC
CAATITGCTC
GCCTGGAAAA
AATCTTTATA
TTGGGTITTTC
CTTAGCACC
ATTCCCATGC
ATTC'ITAAAA
AAAGGGGCTA
GGCACGGATT
TATGTCTTTG
CTATGGGAAA
TTTTAATTTT
CCCTI'ATTTC
ATCTCATCT
TTAGTGATTG
GGCGCGTTCA
GAGCGCGGTG
GACGATTCTA
AGCCGGGATT
AGAGCAAGCG
TTTGCAGCGC
TTGTGGGCAT
INFORMATION FOR SEQ ID NO:82: SEQUENCE CHARACTERISTICS: LENGTH: 777 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .777 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:82
ATGATTITAG
AGCTATGGCG
AAATTAGGCT
AACAAAAAAG
TI'CTTCCCCA
ATCGCTTCTT
CAGCTCCCTTI
ATCGCGCTTA
TTI'TTGGTGG
ACCGAACTT
GTCTTTTCGC
TGGCTTTATG
'TAGGTTTAG
CCCT'ITTGAT
TGCTTI'TAGG
TATGGGATTT
AATATCGT
GCGTCTTAGG
TTCTGGCGAG
TAGCCTTATT
AAAACAACCA
GGGTTTTGCT
TATTTGAAAG
TCTATC7.I-Tr
CGAAATTAGA
CGGCTTCTTT
TTCTAAAGAA
GGGCGTGGCT
ATTATTTAAA
GAATAGGGCT
CAAITCTAGC
CGGGAGCGTG
CGCTATCGCT
GCAGGATTTA
TCTTTGCAGC
GGGGCAATTT
AGGC'FrGCTC
GCAAAAAAAA
GAGTTI'AATG
AAAACCXT
CAAATCTTAT
GGGTITGTTGG
AAAAAGGATC
GCTCAGATCG
TCTTATTTGT
ATCTCCACAG
ATCTTACAAC
ATTGGGGGGA
AGCCCTAAAG
CCTrTGGGC
GCGGCTAAAA
CCTTTG'ITAG
TAGAAGCGTT
TACAC'FrTTA
GTTTTAAGAC
TAAAAGCGFr
CTTCTTTTTT
ATTACGCCAA
CTCTTTTCCC
GCTTGCAAAA
TAATGTTAAG
ACACCCTAAT
TAACCAAACT
TCTCTTTAAT
GGGTTTTGGG
GTATTAr1'TG TCCITrAGTA
TAAAAATACA
TTTCAAGCAA
AGACACCACA
TAGAGTCTTC
TAGCATTGCG
GGCGTGGTTT
CAAAGAAATC
CACTTCGCAA
CTTTTCTTTA
TTCGCTTTTT
TTTIGCGT
.9 9 .9 9* 9 *.99 9 *99 INFORMATION FOR SEQ ID NO:83: SEQUENCE CHARACTERISTICS: LENGTH: 231 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc feature LOCATION 1 .231 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:83 GTGCTAAAAT ACCCTACRRT GTTCATGTGT GCGGATGCGG ATGATTGAAG TGTITAATIT TAGGG TTCT CAAGTCAAAG CCTGAAGCC CCATTTTTTT AATGAGCTCC AAAGACCCTA AATITCCTTT TAGAAAAAAA GCGTGAAAAT TACCAATCCA
TCATTATCAG
AAGACATGCA
AAAGCTTGGA
CGCATTCGTT
TAAGGCGGAC
AAAATI'AAAG
AGATTrrTAA
T
120 180 231 INFORMATION FOR SEQ ID NO:84: SEQUENCE CHARACTERISTICS: LENGTH: 540 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc feature LOCATION S540 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:84
ATGCITGCT
TTGATAGAGA
CTTATTTTTA
GAAAGC-ATTG
TTGGATAATT
AATAGCAGTA
GTTTTATTAG
AAGGCTAAAG
AAAGAAAAcc
GCGCGGGAAG
GCGCGATCAA
TAGGGAGCGC
AAGGCTATCA
TCATTCACAT
ACTACATCCA
AAAACATGGA
GGAII'TTG
ACGCCAAAGT
GAATGAGACT
TTI'AACGAGA
GGGGAGTTAT
AATTGAAGAG
AGAAACTAAA
CACCAGCGAA
GTTTTTIAGC
CGTGAGCAAT
CAAACAGATT
TTAAAAAAAG
ATGTGCCTTA
AGCCCAGAAA
AGITTTAGCC
GAGCACGCTC
ATGTIWGCTA
GTCTTAAGCG
CATGTAGGGC
CTAGAAAACA
CGGTGCCTAT
AAAACCCTGA
CGGAGAT171 ATTTAAAcAG
TTTTTGAAAG
AA.AAAATGGT
TGGCTAAAAT
TTAACGCGCA
TCATTGATAG
TGGTGTGGGC
TACAGAAAGC
GAGCGTGTTT
CTACACGCCT
GGTGCGTGTG
TCAAkAAGGGC
TTITTCTTTA.
TAAGGAATTT
TTTGATAGTT
ft ft* INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 639 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .639 (xi) SEQUENCE DESCRIPTION: SEQ ID ft ft ft.. ft
GTGTATGAAG
'TI'AALATCT
AITCGCGCCA
GCCAATGTGC
AGCGCTI'CAG
GGGATTAAAA
GTGAATGAAA
GCC'FrAGAGC
AATATCTTAG
'FIRA'TrCA
AAAGGATCAC
TITGACACTAA
TTGAGGGGGA
ATATTGCAAT
TGATGCTCAA
AT'rrAATCGC
ATGGCGAATC
AATI'GCGCTA
CCCCTATTGT
RCCAAAAGAA
TCTGGCTI'CT
AGACTTTGGG
ATTGTCGCGC
CCCTAAAGAC
GCTTAAGCCT
TGCAGCTGTG
AATAGGCGAG
CAAACAAAAT
GGGGRGTAAA
AAGCACCAAA
CAAGGGATCC
GCGACTGATT
ACGATTGAAA
AGCGTGTTTG
GACATGAAGC
CCTAAACTCA
GGCGATATAC
TI'TGAAAACA
AACAARGTRG
GAGACTITTG
CTAAAACGAG
TTGATCAAAA
GTITAAACCC
TGGCTAAAGA
TTCAcCCAC
CGATAGAAA
TAGAAAACTC
TFI'TAGAAAA
TCRCAARRGT
ATCCCAATAA
TAAAGTGGGC
CATCAAACTC
CATICTTAAA
AGTCCCTCCT
TCAAATTA
CGTGAAAATC
CAAAGAATTA
TAAGATCGTC
CAATRCGGAG
TGTCGGTAAG
120 180 240 300 360 420 480 540 600 GAGCGAGCAA AA TFIAGAAG AAAAAAAAGA AGGCGCTCC INFORMATION FOR SEQ ID NO:86: SEQUENCE CHARACTERISTICS: LENGTH: 444 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc feature LOCATION .444 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:86
GTGATAARGA
GTATCGTTTG
GACAAAAAGA
ACTAAAAACG
TTAGAAAAAA
CTCGCTAAAA
CTATCI'TTG
GGGTTGATGA
AAGGCTATAT
TGGCGTATAG
GCGGTAAAAA
ATAAAAAGCT
GCCCTAACCT
ACAATATCGC
GGCCTTAT
TGCACATCCG
AAGAGGAGAT
TAGTGCGTTC
ATTTTACAAA
TTATGATTrc
TAAAAGCCAT
TGAAGGGGTG
TGAAAGGACT
viTl"
CTTATGCGTA
GCAGCGGATT
CTCCATAAAA
ACTAAAAATA
AAAAAAAGCG
AGCATGCCGA
AAAAGCAAAA
TAGTTAGAAA
TAGAAACCGG
ACCATGGCTC
GCGGATTAGA
ATAAAAAGTT
TTGTGAATT
AAACCCAATA
TTTATTTCTT
AACCAAAAAC
AGAAACCGAG
AGGCGTGGAT
TTATAAACAA
CAATAAAGCC
CATGGACGGC
120 180 240 300 360 420 444 a INFORMATION FOR SEQ ID NO:87: SEQUENCE CHARACTERISTICS: LENGTH: 843 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DI;A (genomic) (iii) HYPOTHETICAL: NZ- (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE; ORGANISM: He.::zoacter pylori (ix) FEATURE: NAME/KEY: rniscfeature LOCATION .843 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:87
GTGATGATCG
ACGCCCATTA
ATGGAGCGCC
GAACAAGCCC
TTAGCGGAT
CAAATGGGGC
ATCCCAAAAT
TCACTGACCC
GATACTCTT
AAAGTAACGR
TGATGATGAC
GAGCGAGCGG
GGTGGAATT1'
TAAAAAAGCT
AATGAGCGAA
CGTTGAAGCG
AGGGGGCAAA
CTTGCACCTC
AGCATFI'ATG
ATCGGGGCTT
TACAAGGTrA
TTCCCCTATT
GAAGCGGAGT
ATTIGTGGCGA
CGGACATCCC
TGCAAAGCGT
AAACCATI'GA
TGATrGTGGT
TCCTATCGC
CCCAACGCCC
TCATTTACTC
GGCTAAAGAA
TTCTIATAAT
GATTGATGAA
TAGAATCGCT
GAGCGTGGAT
GTCGTAACCG
AAGATTGATT
GATATGCTCT
ACTGAAGATG
GATAAAGATT
GATGACATC
TFIITTACAAC
GAAGCTCAAG
TTT
GCTTGATI'AA
CTAAAGTGAT
TTACCCCCCC
AAATCAAAAA
TCTTGCTAGA
TAGAAAGGGC
GCCAATTAAA
GCTTTCTATC
AACCAACTTG
TFI'AGACACC
AGGAACAAAC
AATCGTGGAT
AGAATCGCGC
TAAAGCGGTG
AATCGGCTAC
CCCAAGAAAC
CCTTCAAGGG
GATGGGGCGC
GGGTTAGTGC
TTATAAAG
ATGCCTTTAG
ATTTTAGAAA
AACCAAGCCG
GCCAAAGGCA
TGAG'TTIAG
AAAGCTTACT
GCWTGCATGC
CCCAAAAAGA
ACACCCCTAA
AA.AAGATCAC
CCACCATTAC
ACAGAGAGAT
GGTAGGCACT
AGGAAGGGGC
CCCCTFI'GCC
GGTGGAATAC
CTATCAAGGC
TTCTACGAGC
TGACGAATTA
TTTGCAAAAT
420 480 540 600 660 720 780 840 843 INFORMATION FOR SEQ ID NO:88: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 432 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc_feature LOCATION .432 (xi) SEQUENCE DESCRIPTION: SEQ ID N0:88 a
ATGAATTIT
TTATTGATCC
AAAGACATCG
AGGCAATTAG
TCTATGCTGG
CCCTCTCATT
GAACGCCAAT
CGCCTTAAAC
TTAAAATCCT
TTATAGGCGC
TAACGCAGCA
CC'ITCATGGT
AAGCCAAAAA
TTGAAGCCAA
TACTITTI'GA
GA
TTTAATGGAG
TCCT'ITAATC
AAAAATCGCC
GCAAAGCTCC
GCITI'TAAAA
TATI'TATAAA
TTTATGGTGC
TTAAGAGCCA
TATGGCTTGT
CTTGTAGATG
AACGAGT'AG
GAAGAAAAAA
CAAAGTGCCT,
GTTAGCGAAT
TTGTTTCTCA
TATACCCITI
AAGACAATI'C
AAATCGCTTT
TTI'ATGGGAT
GTAACGATAG
GCGGTGGTGG
TAAGGGCGTT
GCCTTATTTG
CTI'CCTTTCT
CTTrAGCCCC
CTTACACATT
AITITTATGC
GGAGCATCAA
120 180 240 300 360 420 432 a.
a .a.
INFORMATION FOR SEQ ID NO:89: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 219 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .219 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:89 GTGG-GGGGCT TAGCCATGCT GGGCTTTTTT' TATAATATTG GCGACGGCTT TCTCGCAATG CGCGCCTAWT TATACGGTGC AAAGAAAAGc TCAAAAGAAG CGCGTTAATT TCCGCATGCA TTGATTTCAG ATCCTAGCGT GGAAAATGTA GGACCTAGT INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 933 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (gerlomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .933 (xi) SEQUENCE DESCRIPTION: SEQ ID AAAAAATTTC GCTCGCCACA TCCTTTCCCC TTTGCTTTTG TCGGGCTAGT GGGGTGGTG a.
a a a a a a a. a a a
GTGTGCTGGA
A'ITGTTATGA
AAGCCTGAAA
GCTTGGGGGT
TCCA'FrAGAG
ATTGGGGCAT
TTAGAAGACC
ACAGGCATTT
CTTGTAAGCT
CCCCAAAAAT
T1'TT~l:CATT
GGCTTTGGCG
CGCATTGGCG
TITGGCAAAA
GCTATTGTIG
ACCATGCTTA
CGGATTTGAT
TAATCCATCT
ACCTWTCTTT
TAGGCTATTT
ATGTCCTAA
GCGTTATGGG
CTGAAAAGAT
TATTG.AGC
CTTCTACCAT
TAGTGATGAC
CAACGGATAA
CGAGT7"IG
CGATTGCTGG
GCITTl'GGA CGTTrAGI-IT
AAGAAATTGA
TCAAGGGCTT
TGGAGGGATI'
CTSGCAAGGC
TGGGCAACCC
AGCGACCACT
GCTITTAGGC
T'CATTGTA
GATI'TTAGCG
TGCTGAAGAT
GATTTCTAGG
AAACGCTAGC
CTCTGTGATT
CATGCTCTCT
TATTTATGAA
GTT"ITCTAGC
GAGCTTAAAG
TTGATGATGA
GGAGAGGGGA
TCTAGCGTAG
CATATTTTAG
ATTGGGATTT
GTTGCTTATG
ATGAGTCAAT
GCGGTGATGA
TTCTATGCGA
CTTTCGGTTT
ATCCTCAGCA
TTGTTcAc
GGGGCTAGCA
ATCGrI'CCGG
GTGCGATCAG
CAT
GCGCTTTAAT
TTAAAATCAT
TCGCTATTAT
TGCGCTTCAT
CTGGATGGT
TACATWATY
TGCTC!TTAA
GCACGGCCAG
CGATl'TTCAA
TAGGGGTGGC
TCGTGAGTTA
TTlTTTTGGTC
CGGTGATTT
GCTrl'ATrGT
GCACTAAAGA
CGTGGTGCCG
TAGAGAGATC
TTCAAGCCTT
GTCTATCCGC
TATTTCTI'TA
TGACTTGAGT
CCCTTGGATC
TTCGCAACTG
TAAAAACGCC
TTGCATCGCT
CGCATGGGCT
AAGAATGACG
ATACGATAAA
AGCGAGCGTA
GGCCTTTGAA
INFORMATION FOR SEQ ID NO:9l: SEQUENCE CHARACTERISTICS: LENGTH: 345 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .345 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:9l
GTGGGGCTT
TI'CACGCATA
CCTAAACCAA
AATCTTTTGA
GCGAATC=I
GAAGAGCTTT
TTATCGT"FI T
ATCAAGCCCT
ATGACGCT
GCGCTTATTT
TI'GACAGCAA
CTCATCATTC
GTTTITAAI'
TGTCACTCAA
AAGCGCGCAT
TAGCGGCACT
GACTAATCGC
GCATGAATAC
ATAATGAAGC
ACCCCCCCCT
GCGAGCTCTT
AAAGAAGGGG
TGGAGCGAAG
ATCAAAAAAA
ACCAAACCTC
ATTTCACGCA
TAATCAGCTT
CAAGGGATGT
CCTTCATTCT
TTAGG
CCCCTATGCT
ACTCACTATC
GCCTAACGAC
GAAAATCAGC
TTTAACCAAA
INFORMATION FOR SEQ ID NO:92: SEQUENCE CHARACTERISTICS: LENGTH: 600 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geriomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .600 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:92
S.
S
*5 S
S
S. S
S
S. *5
S
S
ATGCTTGTAG
TATT"CTAGAA
ATTGGGGCTT
GTGATTGACG
TTAGTGGATA
TIATAGATG
GAAGACATGA
ACGAAATTAG
AAGCCTATCA
AATGAGTATT
GGCCAACAGG
TGCTGGCTAA
TGGAGCAATT
CTAAGGATTI'
CGACAGGGCA
GGGGTTATAA
AAGATATTTA
ATGAGAGTAG
GTATCTTC
TAGTGGArl'G
CGTGGGGAAA
AAAATACAAG
GAGrT-::LAT
TGC-TAAAGAA
ITG ATAC CA.7AT.
ACGACGACI'
GTGGGCATTA
GCTAATAAAA
ATTGAAGCTT
GATAAGGAAA
TCC ITAGTC
GGGGTGTTAG
AAT?'GTT
GAAGTGCCTA
GGCTTTAGTA
TGCTAAATI'
TCACTTTAGA
TGAAAATGAG
TGGAATACTG
AA.ATTGCCGG
TTI'CGGTTAC
GGATTGACAC
CTT TAGTGCA
TGGATTGAA
ACCCTAATAA
AGCCGCACGC
CAATTATCGC
TATAGAAGCG
CGA'TITTATT
TT1'GAAAGAG
CACTAAGTAT
TITAATCTT
TGAAAGCCAA
AGTGGCTACT
GGAACAAGCA
INFORMATION FOR SEQ ::3 SEQUENCE CHARATERF:::S: LENGTH: 792 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: 168 ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .792 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:93
GTGGGAGGAG
TATGACCGAT
TTTAACGGGA
GCTITTTGA
AGTCATATCA
ACCTGGACAA
GTGGTGCTAA
GGTAAAATGC
TCGGTTAA
TATTTTGTAA
GTGCGITTG
GCGAGCGTGA
GTGGG-GCTI'A
CGAGTGGCGT
CGAGCTTTAT
TGGTrAAAAG
ACATCATGCA
AAAGAAACGA
ATTC'ITCTAA
CGAGCGTGAA
AACCTCAAGT
AAAATCCAGC
CGCTCAACAT
CGGCGAGGTT
TGGGTGAAAA
TCACAGGAGG
AAATGGGCTT
TT
TICTGGGGGC
CGTGATCCTT
TTCFI'GGCT
ATTCACTFITG
TTCCTTGCTC
TGGGAATI'AC
GGGC LTGAGC TrACCAACAA
GGGGTTAGAG
GGGTAGGGAT
CAC?!'TATTG
CGAAATGCAT
GCAATACCAA
AATGGCACGC
GGGGGTrATG
AATAATGTGG
AGCGCGAATG
TCTGTGTTGA
GGCTATGATT
TATCATTI'CA
TTCGTCATGC
AGCCGTAAAT
CTFI'TGATCA
TACCGCAAGG
TTGTGGCGTT
GATCTTAATA
=1 ATGGCTT
TGGCTTATGG
ATGTGGGGAT
AALACTTATGG
ACCA.ACGCTA
TCATGTTCAA
TAGGCTTGAG
AITCAAAC CC AT'FrT"GGTAA AAGCTAAkAGG
GGGAAATTT
TGATGTATGT
TCACTGGGAA
GAAkTGTGGGC
CTATAGCGGT
GTATGCGAGG
AGGCAATGCG
CAACTACAAC
ACAA.AAAAGC
CGGGATGAAA
TTCTAACGAA
AAAITCCTAT
CGACAATGTG
TAACACTTT
GAATGCGGG
TGTGGGCATG
a a a. a INFORMATION FOR SEQ ID NO:94: SEQUENCE CHARACTERISTICS: LENGTH: 1017 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1017 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:94 a a.
a a
ATGGACGGCT
ATC'ITTGCCG
RTGACTGGAG
GAGAGTCATA
CAAAAGGGCG
TA'TGGCCATA
TTAAAAATCG
GAGTGCCAGG
ACGCATrI'TC
CAAGGCTATG
AAAGACGCTT
GGAAAGCCGG
CC=tTAAGTr 1
ITAAATAAAG
AATAACAAAC
AACAACCGCT
ATTGATGAAG
ATGGGTITAA
GGGATGATGT
CGATGGTGCC
AAGATITCGC
AGAACGCTTC
TCGCGCTCAT
CTCTCTTTAG
TITATGATGT
TAGGGG'IT
ATGTCATCCT
TGAAAGAAAG
TAACTTTAGC
GCTTACTGGT
ATTTITAAATT
GGACGCATTT
ATGAATCAGG
GAGTGGGATT
AATGCAAGAC
GAGCGCTITA
AAAGGGAATA
CCTAGCTCCT
TTAAACAGC
TGCCTCTCAA
TAGCGGCGAT
TAATTCAGTG
AAAAGATGAT
TTCAAGTGCG
AAACGCCCTT
CCAACTCAAT
TTI'ACGAGTT
AAAACCCTIT
AATCTTAGGC
AGCGATTCAA
GGTl'CAGGGC
TTGGGCCAAA
GAAGTCAAAG
GAAACGATTG
AAAGATTA
GTTAGTCC
GGGTI'CAAAG
GAA'PTAGTGC
GGTGTTrI'TA
AAAAATTTAC
GGGGTGAGCG
TTI'TATTACG
CAAAGCATTA
TTGA ITCTAC
AAGGCTCAAA
AACTATI'CAA
GCCCTTGCGC
GAAATTGAA
AAACTCAAGT
AAAATGAATG
'ITCCCATAGA
AAATTCACGC
CTAAAAATAC
AAATCAAAGC
CTTTAGGGCA
ACATGCT1'AA
AGCTTAAAAT
TAGGGGATAA
AAAAAGTCAA
TTATAGGCTT
CCTTATTGGA
TCAATGCCCC
ACCACCAATT
AAGTGGATI'C
~TTAAGGTT
TATCCAACAC
CGTrAAAATc
ATGCATGCTA
TAATATCCGT
CCGTrrGAAT G=rAGAAAA
AAACGCCCTA
AAACTACAAC
ACTTGAATTG
AGACTTTTT
TCTCAAACCT
ACCGGGTAAT
GCGCTTATCC
1'ITAAAGCTT
CATTCCTTAC
TATCRCTITA
TGAAAAT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1017 INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 438 base pairs TYPE: nucleic acid STRAlNDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .438 (xi) SEQUENCE DESCRIPTION: SEQ ID
C
C
C
CC
CC..
C
C
CC C
CCC.
C
CC
ATGCCATACG
TGTATGATAA
CAAkATCATTA CAAATCTTTT
TATTACAAGG
AAAGAAAGCT
CGITATGCGA
TTTCA.ATATC
CCTTIAAGAAA
ATTTGCATGC
AGACAGAGCC
CTTTTGTATC
ACATCTTAAA
ATGAGCCTAA
TTTTAGTGAT
CAAGTCT
AAGATITI C
CAAAAGCTAT
TTGCTCTTTG
CCAATACGAT
CAAACTCAAC
GATTGAATTA
GAACACCCTT
AAACGCCTTT
CTGTT1'TCTC
GAGTGCTTGA
GATAACAACC
CCCGTA ETCA
GCGATTITAC
TTAGCGTATT
TATTGTTIT
CITTTGCCCCC
AAGACTTGAT
AAGATGAGAG
TCGCTTCTCA
TGCCTAAAA3.
TTGAACACCA
TTTAATTGTT
AGCGCACCAG
GCTGCAAAAT
CCTTAAAACT
AACTCCAGCT
GGTGGTGGGC
GAAACAACGA
INFORMATION FOR SEQ ID NO:96: Wi SEQUENCE CHARACTERISTICS: LENGTH: 180 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc feature LOCATION 1. 180 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:96 .0C 00# 0
ATGCCTA'ITA
GGCATGATGA
GTGGCGAGTC
ACCCTCTCTA TCITTTCCCC AATCTII'TTA GTATTTA CGCTTCCAGT TACCAATTTG TTATTI'TAGA TGGGCTTGAT GGGCGTGTCG CCGCTAGCAG TAI-TTTrA TCATGGCGTG TTGGTTAGTG CAAGGCTTAC CAAACACCAC INFORMATION FOR SEQ ID NO:97: SEQUENCE CHARACTERISTICS: LENGTH: 699 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .699 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:97
ATGCTTTCAG
CTI'TCCTG
ATCATTTATG
AGCTCTTTCT
G7 1TCAGGGG
CTCGCTGGTA
GCTAAAAGCG
ATGCCT'ITAA
TACCCTCTTT
ACTTCATATA
'ITTGAAGATT
AAT ITTAGGG CCTI'GCT1'TC
AACTTTCAGA
GAGG7ITTTCT
CGCACATGGG
CGGTGTITAT
TCTTGGAAGA
CTCCTGTTIT
GCATTGGTTT
TGGCTATCAT
AAGATGTGTT
TAA.ACGCTCG
ATTI'ATYCYA
TAA.AATGGGG
AATTITATTTA
AGCCTACGCT
AGTCGTGGTG
GATGTITGCG
ACGCGCCAGC
TGCAGCCTT
TGTGGGAGAG
TGCCGGGACA
CTTTGGCAAC
TGAGGTAGGG
AAGCGCTTTT
ACITACGCCT
ACCCCCATAG
CAAAAAGATT
CTTGG0GTTT
CATGGCGTTA
AGTTTAGAAA
TTATGATCG
'I "GARCT
AGCCTCATTC
TTAAAAACCG
GTTTTAAGCG
AAAACCGAT
TATTACGCTT
CCATTGTGGC
TAAAAACCCT
TTTCTTTCAA
TCGTCATGGG
TCGCTCGCTT
TTTTIAATGGC
TGTTjAGGGTT
TATCAGCGGT
GGAACAACCA
TGATTTTAGC
CTTGCTCCCG
GCTGTGCATG
CATCGCTI'AT
TGTTGAAGGG
ATrATTTA
TGGATCGATC
GAATGTGGGC
TTTTGCCACT
TTACATRCTC
AATCAGCGTG
CTTTGATCTT
.0.
.0 INFORMATION FOR SEQ ID NO:98: SEQUENCE CHARACTERISTICS: LENGTH: 96 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genoraic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NTAME/KEY: misc feature LOCATION .96 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:98 GTGGAATTGA TTAGCAATAA CCCTAACGCC AGCCAACAAT CTATCGTAT TCC TTI'GGAG ACTTTTGCCT TGGCGCGAGC GITAAAGGGA ATCTFI' INFORMATION FOR SEQ ID NO:99: SEQUENCE CHARACTERISTICS: LENGTH: 513 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .513 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:99
ATGAAAATT'
TTTGTGATGC
AAAATTCTAA
AGCGCTCTCA
ATCGCTTTTI
AACCCITTTG
GAAGAAGAAA
AAAGTGGGCG
CGCGCATI'TG
TTGGGACTGA
GTTTAGGCAT
TCGGTAAAGA
CTTCCATAGG
TAACCGAAGA
AAGACAATGG
GAGCGATTGA
AGAGCGTCGG
AAGCACTCTY
TGGCGTGAGG
TGCTGCCGGA
CACCAGAAAG
CTATAATGTG
CATGCGCTGT
CATCAAGTTT
AGAAATC TT
TAGCGCTAAA
TYCCCAAACA
GGTAAAGCAG
TTGTATTTTA
AGCGGCTATA
ATCCAAATAG
GATGCGGGCA
TTCAATTCCT
CATGATGAAG
AGGATAGACG
TTT
GGGTGAAACT
AAAAACATTC
TGGTAGAAAA
GGCCTATGCC
TTATGATAAG
ATGGTTATAA
AATTACTGCA
ATGTGATAGG
CACCCCCATG
TCAAACGAAT
CG.CTTTAGTG
TACCCCTGCG
CGCGAGCCAC
ACTCAAAGAA
TTCTAGCTAT
GCCGCTATAT
S S S. S INFORMATION FOR SEQ ID NO:100: SEQUENCE CHARACTERISTICS: LENGTH: 99 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (gerioric) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 99 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:l00 GTGCGAGCCG TG TTT GTCTT TGGTITTGAAA GCGGCGWTTT GTATAGGGAT TTTTTTCTAT GGCGCTI'ATI' ATFI'CCTAGA TGAGTTIA ATCAAGCTC INFORMATION FOR SEQ ID NO:l0l: SEQUENCE CHARACTERISTICS: LENGTH: 210 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular S OS S S
S
(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .210 (xi) SEQUENCE DESCRIPTION: SEQ ID
GTGAGGAGCG
GGTATI'GGGG
CACCCAAGAT
TTTGGAAAAA
GTAAAAGATI' AGGCTATACC AATCAAGTGA GGTCAGATI'T AGGCGCTTTA ATGGTTTGCA TARRAATGCA TTTGTGTCT AATGTGGAAT ATCAACCCGG CCAGCGCGCT TCACCGATAT TGTCAATATC CCGCCCTAAA ACGCTACGGC GGCACGCAGA T TITTAGACGT 120 180 210
S..
S.
S
S. INFORMATION FOR SEQ ID NO:102: SEQUENCE CHARACTERISTICS: LENGTH: 390 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc...feature LOCATION .390 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:102
S.
5 5
ATGAATCTTG
TTITGTGGGCA
TITAGCGTGA
AAAGTTITG
ACCT7I CTT
GCCATTTCTT
TTTTTGGC TA
TCTTTTTIGTG
AAATGATGCC
ATCTCATAGG
GTGATGATTT
CTTATGGGTT
ATGTCITAGG
AGAATTTTGT
GGCCGCT1CTA
CAGTAAATTT
GTGTTTTIATC
TGGGATI'TTC
AGACACTTITA
CACTAACCT
AGGCGTTIAAT
GGAGGGGCTA
TTAATGTTTG
ATCGGCT'rrA
TTI'TAACCG
AAACTCTTGC
?I'AGGGCTTA
TAGGGAGCTC
AAAGTTTCCC
TGGGGCATTI'
GAGTI'TAGG
AAAAATCCCA
TTGGGGTAGC
GTTAAGGTAT
TTTAGGGACT
GGCCGCTAAA
GGGTITTTACG
ATACCTTGAA
TATCGGTTGG
INFORMATION FOR SEQ ID NO:103: Wi SEQUENCE CHARACTERISTICS: LENGTH: 237 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .237 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:103 ATGTTGGAAA AACTGAITGA AAGAGTGTTG TFI'GCCACTC TGCATTGCCA TGTCGTI'AGT GTTGGTGGTT TTAGGCTATG CACATGCTCA GCCATTTARA CACCATTAGT GAAACGGATT TTAGTGGATT1 TGT1'GGTI'CA TGGCCGGGCT TGT TTT GATG
GTTGGTTGCT
TGTTCATGAA
TGGTTTTATC
GTGCTGCTCG
AGCCCCTTTA
AGAGITGTGG
AGCCTTAGGT
CCAG'FTA
S.
SW.
INFORMATION FOR SEQ ID NO:l04: SEQUENCE CHARACTERISTICS: LENGTH: 306 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .306 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:104
ATGCACTATC
F1AAGGATCA.
GCTCG'TTI'G
CACCAAAGCT
ATCCAATTTT
ACACTT
AATI'AACAAG
AAATGCGCGT
GCTATGTGGT
TCCAACTGGG
TAAGCCCGTT
TTTCAATATA
GTTTGTT'GC
TTTAATCCCC
TATTGCGGTG
AATGTCATTA
ATACAAGATC
TFI'ITAGGGG
CTACTCATT
CTAATGGGCT
SAAAGCATCG
TTITIATAAC
TITTTGTATC
TATCAGGGAG
ATGTTTGG
CTAAAATCAG
TTGTCATGTG
TAACGGCT'G
TTI'AACCCCA
GAGCTTTITA
T1'TTAAATI'A INFORMATION FOR SEQ ID NO:l0S: SEQUENCE CHARACTERISTICS: LENGTH: 45 base pairs TYPE: nucLeic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION (xi) SEQUENCE DESCRIPTION: SEQ ID NO:105 GTGGATATGA AAGACGCTGT AGGGACTTAT AA.ACTAYTCA GGGCT INFORMATION FOR SEQ ID NO:l06: SEQUENCE CHARACTERISTICS: LENGTH: 3081 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FE.ATURE: NAME/KEY: misc-feature LOCATION .3081 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:106
S*
05
S
S
*0e* 5* 0S
*W
S
GTGTGTF1'AG
GAACAAAAAC
AAGCAATGGG
AGCAAGGACA
TATGACGCTG
ATAGAAGAAT
TTAGCTI'ATA
AAGTI'GGATA
GATATI'AGTC
CTAGCCTTTG
CGCGCTAGAG
r1TTTAACCG
'FIAACCCCTG
TATGGGGAAG
AATCGCTrTI'
GATATI'GTCT
GGGGATAAAC
GTGGCTITAG
GAGGGCAAGA
AAAGTGGCTT
AAAAGCTATG
GGCACACAAC
TTAGAAGCGC
GAAC'FITTAG
AAAGAATTAG
ATAGCTAAG
GGTATCCCAC
GATrGTTTA
ATGGGCGTAG
TGGAGACC1'G
CACCAAAATG
TACGATAGCC
AACGCGCACA
ACCATCAGGT
GCATGGGATI'
GCGATGAATI'
CCACTGAAAA
TGGTITATCGC
TGAAAGAAGA
AAAATAACCC
AAATCCGTGC
AAATGGGGAT
AAACTTCTAT
ATTTGTTTAT
GCACGCCTAT
ATGTGTI'AAA
TGGTGAATGA
CTAAATI'TAG
CTAATGATGA
CTATCAATGT
AAAATGGAAA
AAAGCCAAAA
TGGATTACCG
CTATGGCAAA
'FTGGTCAT
TAGATAACC
AAAGCTTGTC
AGAACGAGCT
GCTGT1'CGTT
AAAATGAAAT
AAAAGCTCAA
GCACTAATGT
ATGAATTGT
ATCCTGAAAA
GTATGTGGCA
AATTAGGCTI'
TGGAGCAGGC
AGTGAATAAA
TTATAAGGCT
AGAAAGAGAA
GCACACCCAT
AGAGCTAGTG
TAGAGAAACT
TAAATACGAT
TGACAATTI'G
GGAAJAAI
TAAAACGCG--
AGCTAA.=C
T" G J A
TCGA__AA
TATGI'A
CAAAGAGAA
TGATA'IAT%
GAATGGAA;.
CTAG"AAT
CAAATAGAA
CTGAATGT
AAGACTTTGT
ACGCTCATIG
TACCCTAACG
CTITI'ATTCA
TITGGAATI'AT
AATGCTGAAA
AAAAAACCCA.
GCGATTTTAG
ATTGTGCATG
GCAGGACTTG
TACTTGCATC
TTGAGTGAAA
TAGAATTCT
GACACTTCCG
GGCTI'AAGCA
CATAACCCCC
AGAAGCGAAG
GGCTCTATCA
ALATATCC TT
CCTAACGCTA
C;AGAATI'ATT
ACACCCAAAA
GAAAATAAAA
GAAAAGGGCA
GAAGCTAAAA
AGCGATGTTT
CATGACGCTA
GTCAGGGTAT
TTAGTCGCTA
GGGCGTGGGA
AAAATCTATC
ACTAAATCTA
GAAGACrFI'A
GCGCTATAGC
CCGTGCCTAA
CTAATGTGTT
ATCAAATCGC
TGTCTAACCC
AAAACTF1'GA
ATGAAAGAGC
AAAAACAAGG
AAGCCCACTT
GTAACCAACA
AAAACGATAA
TGTATCACTT
?I'GATGATrG
CTCAAAGTTA
CCATGTATAG
ACTTTGTGCC
AAGTGGCTCA
TI'GATAGGAT
CITGCACCAC
AAGTAGAAAA
TAGAAACTCA
CCCATAGCCA
ATCCCCTAGA
ATCTTATCGC
GCGTCAATT
TAAGGCATTT
AAACCGAAGA
TA'ITGGGCAG
TGCATGAATT
TAAGGCAAGG
GTI'ACGCCAC
AAGGCATAGA
ATATGGGTAG
CAGCTGCATG
CCATTITAACC
AGTTGTI'GAT
TAACAACAAT
TAGAGGAATC
AAGGCAAGAA
CTTTAAA.AAC
CTCTCATAT'
ATTCAAAAJAT
AGGCTCTAAT
GAAAATCATG
GCAACGCTAT
GGCTAAGACT
TAAAATGGT
AGCTTTTGCG
TAAAGTGTAT
ATTCATTGGA
GCAAAAATGC
AGACGCTAGA
AGAAI'ITCT
TGCCACTAAA
AAA~AGTCAGT
TAAAGCTCAA
TCCTAGCAAG
AGATGAAGAG
AGTCCAAATG
GCAA.AAGCAG
TCCTGCTAAA
AGATTGCCCA
CAATATITTA
TGAAAAGACT
GCAATITAGA
CTCTAATGCG
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1800 1860 1920 1980
AGCGAGATGA
GCGGAGATTA
GAAGAAAGCT
TTAGAAACGC
TTGAAAAATG
AAAGAAAACG
CAAATAGCCG
TI'GAACACCT
GTGGTGAATG
CCCAATATTG
AGCTCTTATA
GCTATCACTA
AAAAATATCG
TACCTGCAAG
AAAGACAGAA
AACGCTGAAA
ACAAAGAGTC
AAAGGAGATG
ACTAAATCAA
AAGCAGAAGC
AAAGCGAAGA
TAAAAAACAA
TTCAAAGATC
AAGAAAGTAA
CCTCTATGAG
AACAAAATAA
TGTTI'GTGAA
CTIATAAAAC
CCTATAGCCC
ATI'CTGCGC
AACTCCCTGA
CTAAATACAC
CTTTAAA.ATG
ATrATAAGCC
AAAGAGCGAG
ATGATGAAAT
AAATCGCTAA
TGGGTAGAAG
GACAGGCAAT
ATCAAAATAC
CGCTTCTAAA
CGTAATAATC
GGATTATGAG
TGAAGAATTA
AGAAAAGCTA
TGAAGAAGAA
TAAGTATCAA
TAGCAATATG
TGAGATCAAG
AAAAATCAAG
AAGAITAGTG
GGATCATAAIA
TGCGTTCAAC
TTTAGAGAAT
AGAGCCAGCT
TAATGTTGAT
CCCTTGATTA
AAAGCCTTCA
TTGGATTATC
CCCACTCATA
CTTATCAJAAG
ACGCACAAGA
GACGCTATTA
GATTATAAGC
GTGGAGTTTA
GTTTATAAAA
TTTGATGGGT
GAATTAGAAA
GAGCAAAAAC
ACTCTAATAG
CCTAAATCTA
GAGAGGGAAG
ACAGAACAAG
TACTACGAGA
TTGAAGAACT
ATAAAGAGCA
TAAAACAGGA
CAGAGATCAA
TAAAGAGGT
AACTCAAAGA
AAAAGCAATT
TTTTAGAATA
GTTTAAG CCcc
ACGATACTAT
TTTTAAAAAG
ACTCCATTGA
CITCTTACCC
ATGATTTAGC
AAGAAGTCTT
AGCAAGGGGT
TGATTGAAAA
ACGAACAAGA
CAAATTGAGA
TTACTTCAAT
ATTGAAAGAT
GCTCTATGAT
AGAGCCTTTA
ACAAAACAAG
TGCAAGCAAT
CAAGGGCTTT
TAAAGACAAT
CAACATGT
GTTGGATAAC
AATCACGAAA
ACGACTAGAA
TAAAATGAGC
AA.AGAATTTG
TAAGGGGAAC
AGAAATAGAA
AGTGGAAATT
2040 2100 2160 2220 2280 2340 2400 2460 2520 2580 2640 2700 2760 2820 2880 2940 3000 3060 3081 t 4 @040 *9 ~6 0 0~4* 4 4. 4
S.
4 @4
S
4
SS
*9 4 4 4* .4 INFORMATION FOR SEQ ID NO:107: SEQUENCE CHARACTERISTICS: LENGTH: 186 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .186 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:107 ATGGCCGAAG AAGAA).AGAC CGAACTCCCT AGCGCGAAAA AAATCCAAAA AGCCAGAGAA GAAGGCAATG TGCCTAAAAG CATGGAAGTG GTGGGGGI'TT TTAGGGI'AT TGGCTGGGCT AATGAGTATT ITTCGTTTTT TTATATGGTG GGTGGGATGG CTITTAGCGAG ATGTATCGCC
ATGTGT
INFORMATION FOR SEQ ID NO:108: SEQUENCE CHARACTERISTICS: LENGTH: 711 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No 4 *4 4@e (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .711 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:108
ATGAAAACAC
GAAGATATAA
GTGCTCAAAA
GGTCAAGAAG
TTATTGAAAG
AAGACFI'ATA
CAAAAGACTG
GGGAAGCTGA
AAGGCATATC
GTAGAAAGCC
AACAAGGTCT
AGTAAGCGAC
TCGTGAAAAA
CAAGCGGCTT
ACCTAGATGA
ATGCTCTAAA
CCAATI'TGA
TGTCTAGCCC
CTGAGCAACA
AAATCGAGCA
AGAGCAACAT
TAAAAAATAA
TTTTAAATTA
AATACCTACA
TACCATATAT
AAAGCAACTG
GATTTTITCA
CATCAAAAAA
AGCGAATGAG
TGAACTTTTA
ATGCGGAATA
AGAAAAACAA
TGGAGGTACA
AAATI'TCATC
TTI'AGAGGAG
AGAAAGGCAA
TCTTITTGC
GATAACACCT
ACCACTAGCC
GCGGCCATTG
TrArI"ITrCA.
TTAACCTATA
TCCGATAAAG
AATATAAGAG
GCTICCTI'AA
AAGGAATCA
'FrGGACGCAT
TCAAGTAAGA
TATTGTCTGT
ACCAAGAGAC
CTAGCGCTAA
CTTTGAGAGG
TCTCAGAAGA
TGAAAATCAA
TTITAGTTCT
AGCGTTTAGA
TCACTGCTTC
AAAAGCI'TAT
TAGAAAGATC
TCATTGITAA
TTTGATGGCA
CAACCAACAA
TAATAAAATA
AGATTTAGCG
TGTGATTr
TCCCTTAGAC
TTATTGTGAG
AACrTCTCTA
ACAGACGCTI'
GTTAGCTCAC
CCTAGAACAA
A
INFORMATION FOR SEQ ID NO:109: SEQUENCE CHARACTERISTICS: LENGTH: 249 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KY misc-feature LOCATION .249 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:109 GTGAGCGAAA AAGACAGGGC G I TrCITIA GCGAGCTTGT CTTGCGTGGA GTGTTTGGAG AAGACACGCC CATAAAATTG ATTCAAGCCC TAAAGCCTGA AAGGGAGCGG ACTACCTCAA TAAAGAAGTC ATAGGGAGCG AGITGGCTAA TTGATAGAAT 'ITGAAGAAGG TTATTCCACA AGCGCTATCA TAGAAAAAAT
CATAATGAT
fl..
p
LTATGTTGTG
TATITTAGTC
AGAAACCCGT
TAAAAGGACA
120 180 240 249 INFORMATION FOR SEQ ID NO:ll0: i)SEQUENCE CHARACTERISTICS: LENGTH: 192 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE:.,NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .192 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:l1O GTGTATGACA AATCCTTGTG TAAGACCATG GCGCTAGCGT TGAAGGCTTT AGGCGTTAAA AGGGCGt'TGG TGGTTAATGG AGGGGGGACA GGTGAAATCG TGTTGCATGA CA LTACGCAT GCGTGCGAAT TGAAAAATAA CGAAATTTTA GAGTATGATT TGAGCGCTAA AGATTTTGRT TT-RCCCCCCT CA INFORMATION FOR SEQ ID NO:lll: SEQUENCE CHARACTERISTICS: LENGTH: 684 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .684 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:111 a. a a a a.
a a
ATG-TAGTAG
ATCAGTTGA
AAAACCACTC
ATFIAAACC
GATI'TTTTAG
AGCGATTTTG
AGAGAGWTCA
TCACGAAACG
AGAGXAGAGA
TCTACGCAT
GCTAAAGTGG
GCAGCGTATA
AAATAGAGAA
AACTACCCAA
TGTTAAAAAT
AAA.AGATTGG
ATCCTAAAT
ATGAATCAAA
AAGCCCT=C
CTICTITG-1TA
TTTTGAGT
TGGTGGTGGA
TGGCTTTTGG
AAGAAAGGTT
TTTGACTAA
TIAGC COGA
TATA;GAGACT
AACGZA
AGC-CTAAAT
AAAG3G:A7.- TC7T".=AT
GGA..
GAAA
ACITATGGGA
ATAGGGCTT
TI'GAAI'TGA
AAAAAAAGCG
AAAGCGATCG
TI'GTTAAAAC
AGGGAAAAAT
GAGCCGGTGG
GAGTrAGCC TATTrAGACA
GAATTAAAAA
GTTTAAAAGC
TAGGGCCTAA
ACTATCAAGG
TGGCGTTTI'r
CTITTATAA
GCTTCAGCGT
TGCAGCTGAT
CTGGGATTGA
AAAACGCAAG
GCGCGATT
AAGGGTATAG
GCTAGACAAT
TGGGGCGGGT
GGAAGTGAAA
AAGCGATGGC
GGATIFIr GCC TTAAAA
TTAACCCTA
CCCTATrGCA
CTI'GCTAGTC
TTTAAAAGAA
CAG?11'GGAG INFORMATION FOR SEQ :D N::.112: SEQUENCE CHARACTERISTICS: LENGTH: 819 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL. NO (iv) ANTI-SENSE: NO (Vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .819 (Xi) SEQUENCE DESCRIPTION: SEQ ID NO:112
ATGAACAAGC
A.ACGATAAGA
GAGCGTTTGT
CTACTCAACA
?I'AAAAATCA
TCTTTGAATA
GAGAATGTT
GAGACGATGA
TGGGAATACG
AGTAGCGATC
AACGCGTATT
GATGAAAACT
CTTAACTTGC
TTAAAAAATG
TIITAGC
ITGAGAATT
TIAAAAATCG
CTCTCAAAGA
CTI'TCAAGGC
TGATGGGGTA
TTI'CATACGA
AAAGGCATGG
ACTTTGCCT
CTGTGGAGT
TAAAAATAAG
TAAAGATCAT
ITGATGGCGT
GGATTAGCGT
TTTTATTGTT
AATGGGGGAG
TAAGGATTC
AAACGGGCTI'
ITCAAGTAAT
TTCGTATGTT
GCTTAAAACG
TTITGATTTT
ACAAAAGATC
TAAGGAAGCG
CTCCAATAAC
TCAAATCATT
GCGTTTTATC
GGI'TTI'GAT
GGGGGAATGC
CGATCCTACC
TATGAAATGG
TTATCGTTTA
CCCCTAGCGT
TTGCCTATITA
GAATACGTTr
ATGGATATTA
AAGCTCCCTA
AGCGGGAAAT
CCTTTGTGGC
GCTAAAGAAA
CATATCACTG
GCGATGCCT
TTTTAAGTGC
ACATGAACAA
GGCGTTTGGA
ATMIGACAA
TTGCCAAAAG
GAATGCAAAG
TAGACCCTAA
GACGGGTGTC
ACGCGAGAGC
AITGGCTGAG
AACCCAAAAT
ACAGACAACA
ACGCAAAAA
TGATGCTITA
GCTTTTrTTA
TTCCTTAAA.A
ACCAAGCGTG
CATCAACAAT
CTCTTCAGGC
CATI'TGATA
TTTAAAGGAG
CTTAGITI'TG
CGTGAATCAA
CATTITFTAT
AGAAATCGCT
CCCTATCATT
120 180 240 300 360 420 480 540 600 660 720 780 819 INFORMATION FOR SEQ ID NO:113: SEQUENCE CHARACTERISTICS: LENGTH: 45 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION (xi) SEQUENCE DESCRIPTION: SEQ ID NO:113 GTGTCTCGCC CGTTCAAAAC GATCAAAAAA CCCCCACAAC CCCCT INFORMATION FOR SEQ ID NO:114: SEQUENCE CHARACTERISTICS: LENGTH: 201 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .201 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:114 ATGATCGCTG TATTACCGCC CTI'GTITCT ATGGGGAGCT TTGATGAGTG GATTIATAGG GGGCTTGTGG CTTTAATGGT GAGCTGTCCT TGCGCGTTAG TGA TTI'CTGT GCC T TAGGG TA'FITTGGAG GCGTGGGAGC GGCGAGCCGA AAGGGGATT TAATGAAAGG AGTGCATGTT TTAGAGGGTG CTTACCCAA.A C INFORMATION FOR SEQ ID NO:115: SEQUENCE CHARACTERISTICS: LENGTH: 969 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .969 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:115 *9*e
GTGCAACACT
ATI'ATCGCTC
AAAA~T
GACGAGCTTT
AAAGCGGATG
GATGAAGAAA
ITGCAGAAAA
GCGTI'GTTGA
ACTTTGGAAT
TATFI'AATGC
GCGTCGITAG
TITTGGCAAG
ATGAATATCC
CAAGGG ITGC
CTAITGCATA
CAA.ATCTTTC
ATGGTGGCT
TCAAWTTCCT
TTGTGATTT
TGCAAAAAT'
TAAAGCATGC
TGGAAATGAG
.AAATCGCTGT
CAAAAGACAC
AGCITI'TGCA
GTTTGGAAGA
A ITAATAGA AITTTGAAAkAA
AAATI'GATAC
CTGCTTTTAT
ITTTGGATCA
GCCCTATAAA
CTTTTGAAAG
CTATAAAGAT
ATTAGAACAG
CGCCCAAAAT
TAAAA=rICC
CATGAAATC
TTTAGAI'ITA
CGTGAAAGAA
TGCGTATGAA
ATI'AGAGGTG
GAATAAGGAA
AATCGCTCTG
AACCGAACGG
=ITAGAAAAA
CAAACCTTGC
AGCGAGTCTG
CCATAGGTGT
TCTITATTT
GCTAGAGCGT
CAAAACGCCT
AGTI'TGATGT
TI'AAAAGGGC
TI'GGCTAAA
ATTTTGCGCT
TTAGAAAJAG
CCTAAAATI'G
GATGCGGCTA
AATCACTTAA
CTAGAAAATG
CATGCCCTT
CAAATTI'TG
ACTI'?TGAAT
CCTGTGTGI'
CTATCGCrT A TTCACCCG
ATGCGAGCAG
TTTI'AGCTAG
~I IGAATCG
ATTATTITAG
TTICCCCAAG
ATTATTCAAA
AAACGATTAA
AAATCT1'GCA
AATCGCATGA
TGATCGATCT
TGCAGGACAT
AATAGAGGT
ACCGCTGCA.A
ACCAGTTAGC
ATTCACTTTC
AAAGAGAAAC
CGAGAATTTA
GGCGTATTCT
CCCCTTAAALA
CGTGGGGTAT
GAATGTGGAA
GGC'ITTAGAA
AAATTACCTC
TGTTTCAA.AA
TGAAAATCTT
TTTATGGGAT
CGCGCGATCT
TTTACGCGCT
GCAT~TGCAAA
GTFrATGGAT INFORMATION FOR SEQ ID NO:ll6: Ci) SEQUENCE CHARACTERISTICS: CA) LENGTH: 30 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...30 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:116 ATGGAACACC TTACAAGGGG AATTAAGCAC INFORMATION FOR SEQ ID NO:117: SEQUENCE CHARACTERISTICS: LENGTH: 153 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) S (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...153 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:117 GTGGTTATCT TAGGCTCRCA TGGCAAGGAA GAGTATTACG CTAGCAAGAT TGCAGCCCCC ATTTTTAAAG AAATCACCGA AATTTTAGTG CGTTACAATT ACCTATCGCC CTCTATTGCG 120 ATTCAAAACG CTTTGGAAAA AAACCGCTTA AAA 153 INFORMATION FOR SEQ ID NO:118: SEQUENCE CHARACTERISTICS: LENGTH: 237 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE- NANE/KEY: misc-feature LOCATION .237 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:l18 ATGAAAAAGG TTATTGTGGC TTTAGGCGTr TTGGCGTTCG GATGTTAAGG CTcTI'GTAAA AGGTTGTGCC GCTI'GCCATG GCTII'AGGTA AAAGCAAAAT CGT1'AACATG ATGAGCGAAA ATGGCT ITTA AAAGCGGTGC CAACAAGAAT CCTGTCATGA
CAAATGTTTT
GGGTTAAGTr
AAGAGAI'GA
CCCGCAAGCT
AATGGCAACC
TGAAAAGAAA
AGAGGATC'r
AAAAAAT
INFORMATION FOR SEQ ID NO:119: SEQUENCE CHARACTERISTICS: LENGTH: 285 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .285 (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 119
S
S
S S
S
ATGGGGAF1'G
CATGCGAAAT
CAAAAATGCA
GAGGATTTTA
CGTTTGATGC
CAACCAGTCT
TTATGAGCT
TAGAGCTCAA
AAGAGGGCTT
ATTTATTGTA
CATCAGTGAG
GGGGGAGCTT
TGAAGCGATC
GGAT LI'TT'A
TGATGCCAGC
G'ITTCTAAGT
GGGTGCTATG
TGTATTrI'AG
GAAAAACACA
GTGAAAAGTG
TTTATTACGC
CGAGCCATTA
AAGACGATAT
TCCAAGAGTT
AGCCT
TITAAAATAC
TTCGTTGTGG
AACCITGAAA
AGGCTATGCG
120 180 240 285 Sn.
S
INFORMATION FOR SEQ ID NO:120: SEQUENCE CHARACTERISTICS: LENGTH: 462 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO- (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: nuisc-feature LOCATION .462 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:120
ATGCACCITA
CATTTAATCC
GGCGATATTT
ATTGAITI'AA
GATITTCCA
CCCGCATTAT
ACTAAAGCGT
AC2TITI'AA
AAAGTGGGGC
ATACGCTIAA
TCCATGTTCT
TCCATGCGTT
TGCGTTTTGT
TCCAGTATGA
ATGAXTTTA
ATTTATTAAG
TGITTATC
AGAACTTTTA
TGTGGGCTAT
GAGCGAAATT
ATTCAATTCC
TAACAAACGC
CATCACGCAG
TTTTAAAACC
TCTGATGCGC
AGCGCCAAAC
TTACCCCTAG
TCACAAGTCT
AAAGTAATGG
TTTTTGCTAG
CTCACTTCCA
TTATACCCT
AT'ITTTG CC
CCCCGCAAGT
ATAAAGAGCA
TTACTTTGA
I TTTIGAGCG
CCCATGGGGA
CTI'GGGCTAG,
TT_
CAAAAGCCCT
C'.rTTTTCATG
GCAA.AAAATC
AGGCAACCAT
CCAAAACCAA
TT1'ATTCATC
ATTTTTTTTA
120 180 240 300 360 420 462 INFORMATION FOR SEQ ID NO:121: SEQUENCE CHARACTERISTICS: LENGTH: 939 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genornic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .939 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:121 a. a.
a a a. a a a
GTGCAACCGA
TTI'TAACCC
ITTGCCGCAA
GCGTGGGTT
AAAACTTTAG
AATCAAGGGG
GGGCTFI'ATG
CCCCCTAAAA
TACAAACAAT
AACACCCCAT
AAAGAAAACC
CCTACCCCCT
TCCCCACACC
ACTAACCCCA
AAAGAAACGC
ATGACAAAAC
TGAAATCTAA
TATCTTCATG
TCAATAAAAA
TATTCCTTT
GGCATCTAT'
AAATCGGCAA
TGCTGATAAT
GCG7"ITFTA
GCI'GCAGGC
CAGAITCTCA
CTATI'GATGA
ATAACACGAC
CCCCTACCCA
CTTTAAAAGA
CCACCACACT
RGAAAACCAC
AAAAC'TrAT
GCTAGGTAAT
ATATI'TTGGG
ATACAGGGCT
AGGCATTTTA
CAGCGCGCGT
GCTTATGGTA
CCCTTATATG
CTTI'AGCCCT
AAA.AAAAGAA
AAACCACAAC
CTTAAATA.AT
TI'ACACCATT
ACCTAAGCAA
CAAACCTATC
AAAACCCCTA
TTAGCTITAA
AGCGGTTTAG
TATC'FrrCAT
AAAAACCCT'
TCTTTACTCT
TI'GTTTAC
GTI'ATCTCT]t
AACAAAACAC
AATF1'IAGCC
ACCAACAACG
ACCCCTAACG
TCAGAGCCGC
TACCCTAAAA
GAAACCAAAG
ATGCCCATAT
ACCACCCCA
TCATAGGGGT
TGGGGCGTT
TGATI'AATT
TTACAGAAAT
TITI'GCAATC
ACCCTTAT
ATTTAATTTT
AAAGCCTT
TGAAAAAAGA
ACAA.AGAAAA
AAGAATCGTr
AAGAAGGCT
GAAACCGAT'
AAAGAGAACC
CCGCATCCAC
TTI'ATIAGCG
TGGGGTGTGG
ACCCTATTTG
CGTTTTAGAA
TAGCCTGITG
AGGGGACTT
ATTCAAACTG
AAAAGAGATT
GGGTTITGAA
AGAAAACCTC
TTTAGCGATC
AGTCCAAATr TGATGATrI'G
CACGCTAAAA
ACAGAAAATC
INFORMATION FOR SEQ ID NO:122: SEQUENCE CHARACTERISTICS: LENGTH: 957 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (iMOLECULE TYPE: DNA (genomic) (i)HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .957 (Xi) SEQUENCE DESCRIPTION: SEQ ID NO:l22
GTGATGTTAA
CTCACTTATT
TI'AAACAGGC
TTAGACGCTA
GAAGGGCTAT
AGCGATAAGT
TATCCFI'CTA
AATAACGATC
AGCTCGCCTT
ATTTCTATCA
TGGACAGCGA
CTTTTAACCC
F1GGGTAAAA
GGCTCTATCA
AGCGAGCCGG
ATCAGTTTGG
GTAGAGACAT
TGTTTTCGCA
AAATCAGTAA
AGGGCATGCT
TAGAGCATGA
ATTATTITA
AAAAAGGGAA
TAGCGT=IT
CAAAGTATTr
TGCTCACTTT
TCGTGCATF
TAGCTTTAGC
ATAGCC-GGGA
TrATCGCATT
ATAAAATCAC
CGA'ITTATGT
TGTCCAATAT
CAATATCCGC
GATGCAAGCT
CATGCTTAAG
T ITAACAGAA
TCAAGCCGTG
CCATITGGTA
GGTGTGCTI'G
TAAAACTIT
AGTGTCGCTG
TAGCAGTTTT
CACCT=GAT
CAACCACCAT
AGCCATTGAA
ITATGCGGTG
TAAATTCGCT
TCCAAGATCC
AACCACCTTC
GAAATCAAAA
CCAAGCCAAT
GGGATTGAAT
AATGAAAAGC
GTGAGCGCGT
CAAATCCCTT
AGCGAAGGGA
CTTITATTCG
GACATI'AAAG
TTGGTCAAGG
GCGATCCACC
GCGTTAATGC
TATTTGGCTA
TATAGCGTGT
GCACCGAGTT
CTGAAATCAC
TGGCAAAAAG
TTAAAGAGCA
TAGAATCGCA
GTTGCATTTT
CTTACCCGGT
TGAGGGTGGC
GCATGGTCAT
TGAAATGCAT
AAGTGTTCCA
CGATT=~GA
GCACCATGAT
TCGTGTTTAA
TCGGCGTGGC
TGCCCAAACG
ATACGCCTAC
TTTGGXFI'AT
TTrITTGTT
GGGGCATAAG
TGTCAG'FrTT
AACCGACCCC
GTATGATCAA
GATTGAAATC
GTATITTATG
TTCTAGCTT
CCCCATTGTG
AGAAGAAGTG
CAGGTTTT1A
ATTCAGCGTG
GGTGCTTTTG
AGAACGC
p p. a a p *pp.
p. a.
p p a INFORMATION FOR SEQ ID NO:l23: SEQUENCE CHARACTERISTICS: LENGTH: 354 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .354 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:123
ATGGTI'ATAC
GGCAGGCAT
AATAGAAGTA
ATTrCTTTTA
AAAACCCGCT
CGCTTITATT
ATGAAAAAAT
TrGCATCTI'C
GTGCAGTTGC
GTGGGGAATI'
TTGGAATITC
ITTTGTATGG
CAAAAGCCGC
AAGCGTGTAT
TTGGTATTG
TGTAGCAGAC
TA ITGTGAGC
TTTGGCTF'A.
1-1717CTAGGA
TITTCTCAC
ATGCCTGAAC
ATGGCGTTTG
GGCGTTTCAC
TI'AAI'GGTG
ATTGGTCT
TTICTI'GTCAT
AITI'GA'ITGG
GCAAAAAAAG
TA'ITGCTTGG
GGCTGTC TTT
AAGGAATAGG
TACAGCGGTT
GTGGTTITI'G
TAAGATTrT
CGCTTACCAG
=IA
INFORMATION FOR SEQ ID NO:124: SEQUENCE CHARACTERISTICS: LENGTH: 276 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geflomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .276 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:l24 ATG TTTAAAA GTT TTTTGGG
CAAGTGAAAG
AGCGAATGCT
GCTGGTGAAA
GCAGATIAAA
ATGTCATAAA
AAAGGGAAGA
TTGAAAAAGG
GAAATAGAAG
TTCATGGATT
ATACAAAATA
ATATI'ATAAA
AGGCGATAAA
AATGFI'AGAG
TTATI'AGGGA
GAAGATTrGC
AACCACATAG
GTGGATTGCT
ATI'AkA
TITTAGGGGT
AACATGATCA
AAGAAGCTI'
CGGCTGCTAT
TTAGTGGTG
TTATCTATCA
GAAAAAGGAT
GAGAATAGCT
55
S
S
INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 414 base pairs TYPE: nucleic acid STR.ANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .414 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:125 .0.05
ATGGTATT
GTGTrT TTGA
GCATGGATCA
ATTrITATGA GT1'CAAATAG GCGGAA'FTrA
TFI'ATAGGGT
GGGGCGCTGT
ACAGCTI'GAW
AAAATGAAGC
TGGGTI'ITGT
TGCCTGCTTA
TAGATGTFI'C
GCGTGTTCAA
ITTCTTrTTA TGGGATCGAA TI'YCATGCTr GCGGCCTrGA CCACACCACT CAAATCGTITT GTGGCCTTTT GAATCC'FrGC TCATGGGATC AGITTGCTCG TATCCATTTT TACGCGCTTA AC'ICAGCTCT TrAAAGAAAG
CGGCATGGAA
GTTTG;GGGTC
TGATTTCTrrC
CCTCTAT
GGCGAIJGAA
TTGCGATTrr
CTTGTGAAAA
GCGC'ITAATG
GTITTTAGGG
TGCCCTrG
GCAAGTCTIC
TCAAATGCAT
TATCGTGAGT
CGCT
120 180 240 300 360 414 INFORMATION FOR SEQ ID NO:126: SEQUENCE CHARACTERISTICS: LENGTH: 762 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .762 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:l26
ATGCATGAGC
ATACTCTACA
GCCAAAATGT
GAGCAAGGTI
GATIACAGAG
AGACAATI'CT
AACCTAGCCT
AAGAGTTTTT
AAGTGTATTIC
GAATTAA)IAC
AGAAAAGAGA
ATTAGTGATG
CAAAAATCAC
AAGGTTCTAT
AGCTCGCATT
TTTT'GCAAGT
TTATTGAAGT
AATTAGAATG
TTGATTATIT
TTGCTAAGAC
TAAAAACACT
TACTI'ATTGT
ACATTCAAGT
GAAAAGCTTA
AT]?ACAGACT
AAAATTCTI'1 AAGCTrRTA
TAATGCTAAG
TGTAGCAAGA
CATI'AAAGGA
CTI'AGTGAAG
GGATAGAAAA
CAAAGAAAGC
CTTAGACTAT
AATACT1'GGG
AGAAGAGCAA
TATAAAAAG
AAXAATATITC
AACGCTTTAT
GCGCRACAGG
TCTAATAAGA
ACTCTAATAA
AAACAAAGAT
AGCAAGATGG
AGGCGTTATG
TI'ACCCAGAC
AAGCCAGCTA
GGACTTAGAA
AACTACTCTA
AGTTTGTTAG
AATGGAGCAT
AATTTATCCC
GAGCTAAAAG
TTGCCCTAGA
AGAATGTCAA
ACTTGTATGT
CTAAGTATGT
GCTI'TGATTT
AITrAAACGA
CAAGCTTI'GA
AATGCGAAGT
'FITrAAFrCA
AACCAAGCTT
ATCTC TTAA
CT
ATTATTATAC
TAGACATTAC
TATATTAGAA
GTATCTTAAA
GATGTATTTA
TACGCTI'AAA
TAXAGACTI'A
AAAACGCAAT
GTI'AAACATA
AGGTAAAGGT
GAATGCTTGG
AAGGATAAG
120 180 240 300 360 420 480 540 600 660 720 762
S
C.
S
CS
S
INFORMATION FOR SEQ ID NO:127: SEQUENCE CHARACTERISTICS: LENGTH: 555 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .555 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:127 GTGGTCITI'A AAATTITAAG T1'ATACTTAG GCGAAGAACC CCTAACGCTA GAAAAGGCGG AACCCTTTTG CGCTTAAAGG ATGGTGCAAA GCTTAGACGA GTGGCTAAGG ATAACAGCTA AACGCTCCCA TITI' AGCGAG TCGCCCCTTT ATAGGCAGTA CATGTTAAAT TCATTTYCAA 'FTGCAGATCT TTTCC TTATGGT1'A
CAAATATAAA
TGTITTGAGA
CACTAAAGCC
ACCTI'GCA
TGTGATTTI'
CGATGTGAAG
TTACCAAGAT
AACCACTGAA
GGGGTGUTTT
GACAA TI'CA
AATGACGCTA
GAAGGCTTGG
GAATACCCCT
ACCCTAGATA
TTTAGCTTTG
GTTAAAAAGG
AATAAAGAAT
G TrCCTTAG
CGCATFTGA
TAGG4GACTTT
ATCTCATTTA
TAATCGCTAA
AAAGAGCGAG
ATACGATAAT
CGGITATCTT
TGCCCCTCAT
GGCTACGCAT
ATACGCTAAC
TGATAGCCT'
TGACACTTTA
AGACGCCGAA
ATTCAGCAAT
GAAATTAGGA
AGACAAGCAC
TITTAGGGCAG
120 180 240 300 360 420 480 540 INFORMATION FOR SEQ ID NO:128: SEQUENCE CHARACTERISTICS: LENGTH: 198 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .198 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:128 GTGGCCATGA. TAGATTGCGC GATI'ATTGGA GGTGGTCCTG TATGCCACTA GAGGCGGTGT TAAAAACGCC GTTITATTTG CAAATCACTG GCAGTAGTGA GATTGAAAAT TATCCGGGCG TTGGA TTT CA TGCAACCA CAGGTGAG TGCGGGGCTT AAAAAGGAAT GCCTGGGGGG TTAAGGAAGT GGTGAGCGGA U. *U
U
U
*UU.
a. Ut
U
a~ U U INFORMATION FOR SEQ ID NO:129:.
SEQUENCE CHARACTERISTICS: LENGTH: 546 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .546 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:129
GTGGGGAAAA
TTCACCGAAT
AAAGGCGATT
CAAGCTATAA
TCTAAAACGC
CATGGCATAG
TI'GGAAAAAA
ATCATCAGCT
AGCATGGGGA
AGTTTA
GCTTGAGATA
TAGAGCCAAC
TTGATTCAGG
GCGCGATCAG
CCATGAAGGA
GCATTGAAGG
GAGCGTA
CGCTTT1'AAT
GCAGTCAAAA
CAGCTI'GAAT
AGGTCTCACG
GCTAAAATCC
GAGATTACCC
TATTGAAk
GTGGTGGCAA
CATI'GTGCTC
GGTGGTGATG
AGAAATCCAA
TTAGATCTCA
CTCTCCCCCA
TATGACATGA
'rrAGGGCTTT
TIACGCAACG
CAAAACGGGA
ATGCTCA'rrA
AACAGGCGTA
AAAACCTTT-i'
ATCAAAAAGC
TCATGAAACG
GCTACATGTA
ATGATGGGGT
CITTAAAAAC
ATTITTCTC
TTTTAATGGC
AAGAAATCGC
TI'TATITGGG
CGA FTTGTTT
CTITACTATC
TGCGAGCCTT
GCATGTCTAT
AATCAACCAC
GGCGATGGAA
GTCTTTGA.AT
CCTACTCTTT
TAATATCA'rr 120 180 240 300 360 420 480 540 546 INFORMATION FOR SEQ ID NO:130: SEQUENCE CHARACTERISTICS: LENGTH: 741 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NANE/KEY: misc-feature LOCATION .741 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:130
ATGAAAAAA
ACCAAATGGG
GATTTTGAAG
CACACGCAAG
TI'TTTCACCC
GGGCATGACT
AATAAAACCA
GTGTTAGCGA
GGCATTCAAA
ATCAATTACT
TGGT~TTGTCA
CGCATGAAAA
AAAAGCTCGG
CTITITTGAT
ATTATAAAAA
TGTGCAAAAG
ATAAAGCCGA
ACCATACTT
ATGTGTTGGA
GGCCITTGAG
TTIGGTTTTGA
AGAAACAAAA
ACCATTTAA
TAGAAGAACC
ATTCGCCCAA
CTGAGACCCG
CGCTTTAGCG
TAAAGAAAAT
CGGTAAAAGC
TTGCAATTC
AAAGGCTTCG
TAATGTGCAT
CGCGCATTTC
AGAAGGGAAA
TCTTAAAGAG
CGGCTCTCTC
TTTGGAAGTT
CCAACGCCCC
C
CTTACGGCTT
GGCCCGCACC
CAATCGCCCA
AAATACGCCG
ITTGAGCCGA
TTCCACGCCC
GTGCATAAAG
GAAAA4CCCCA
GTGGCTTTAG
ACCGCTCCTC
TCTGCCAAAC
GTCCAGCCTG
CTCTTATAGG
GCTGGGACA.
TCAACATTGA
CTCTAAACC
CTAACCACAT
CTATGGAGTI'
ACGCTAAAGG
ACCTTGATCC
ACGCTI-TCTT
CTTGCACAGA
AATTGGCTGA
ACTACAACAC
CGCTGAAAAC
A'ITGCACAAA
GCATTACTAC
TAAAGCGGTC
CAATI'ATAGA
TTTAATCAAT
GCGTTTGTTG
TATTTTAGAA
GCCTAAAAGC
GGGGGTGGCA
AATCAAAAAA
CGTGATCATT
a a *a a.
a a a a a. a a.
a a INFORMATION FOR SEQ ID NO:131: SEQUENCE CHARACTERISTICS: LENGTH: 1266 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .1266 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:131 ATGAAAATTT CTFI'ATTGGG AAAAACCATA ATGAAGTCAA GAGGGTFI'TC TFI'GCTACCC GTCAGC-CCTG GCA ITAGTI GAATACGATT ATATTGATAG AGCGGCACTA ACGGGAAAAC .AAGGCTGTGA GTGGGGGGAA
GCATGGAAAA
ATTITTTTGAT
TAGTAAGGAT
CACGCACCCT
TTGTTTGAT
CACCACGACC
TATCGGCACG
ACCACTCTAG
GATAAATTCC
TTTAACCCTA
TI'AGTCATGA
CATTCTTITCA
GAAATGCTCA
CCCTTGATTG
CCCTAGGGCG
CTGCAT ITT
ATGATTCCCA
AAGCCAAGCA
CGCCTACGAT
CCACACTI'T
AATI'GTGA
TTTTTTAAA
TAAGGATAGC
ACTAGAAATC
TTTAATGAGC
GATAAGTATT
AGAAGATFFI'
AAAACGATCG
120 180 240 300 360 420
CCCTTC;TGGG
TTAATCTACT
AATTATTTGA
CTCCCTTTAA
TTGACAAAA
AAGGGAGCGT
ATAAAGAATT
AAAATCGGCT
GACAGCAAAG
AAAATCCATT
GAGTTTAAAA
GCCTTAGCGT
CAAGAAATTA
AGT'rrGGATC
AAAGAT
TGCTAGAAAC
TGCTCATCAA
ACGCTAAACT
AAI'CAAAGA
GCGAAGAGGT
TITTTATI'AGA
TAAAATGGCA
CGCATAAAAT
CCACGAATAT
TGATTITAGG
ACTATAAAAT
TAGAATrI'AA
AAAGCGTT-T
AATTTI'CTTC
AAGCTCCTTT
TGTGGAAGCC
CAAGGTTTTA
ACACCCTATT
TTTrAGAGTGT
CGCGGCTTTA
AGATTATAGA
GGAAGAATTT
TGATGCCACC
GGGCGATT
AAGCCTI'TAT
TGTTTCTI'GT
ATIACAAAAT
GTATAAAGAA
TCTTTGCATT
GATCATTTGA.
ACATTGATGC
GTTCAAAACT
TTAAAAATCC
GCCCTTTTAG
GAAAACGCCC
AGGGATAAAC
TTACAAGCCC
AAAGGGGTCA
GCCATAGGAT
CAGGTITGTT
GAAGTCGCTT
AGGGGTGAAA
ACACTAATAA
CTI'GGCATTG
CTAAAACT-r~c
CGCA.AGCGCA.
CTTCTAACGC
TTTATGAGCA
TTAAAAGACT
AAGGGCGTTT
TAAAAACCTT
ATTTAACCCC
CAAGCGCTTIC
TGAAGTTAGA
TGCTITCACC
AATTCAAAGC
GGCTTACCCT
CAATTTTGAA
GCTCGCTATC
AAAAATCTTr CCTIITTTITr
ATTTAAAA
GAACGCI11"T
GTGGGTAGAT
TAAAAACCAA
CCrTTrTGAA
TATCATACAA
AAAAGCGGT
TAGCGCGGCC
GT?1'GrTrA 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1266 INFORMATION FOR SEQ ID NO:132: SEQUENCE CHARACTERISTICS: LENGTH: 162 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .162 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:132 *9 9 0 9.
*0 90 0 00..
a 0* 0 Oa 0 ATGAAAGAAA TCATI'GTCGC CCTI'GTGGGC CAGCCTAATG AACGCTrI'GA GTAACSCCCA TTTRAAAGTG GGGAATTTTA ATGGAAGTGA G TTTGCATCCA WAAAGATCAT CAARTSWYTM INFORMATION FOR SEQ ID NO:133: i)SEQUENCE CHARACTERISTICS: LENGTH: 333 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: cjircular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOT HET ICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEX: misc-feature LOCATION .333 TGGGGAAATC GTCC'ITAATC CCGRGGTTAC CGTGGATAAA
TC
(xi) SEQUENCE DESCRIPTION: SEQ ID NO:133
GTGCATCGTT
CTATCTCGCT
AGTGCTTTAT
TTTAGCCTT
GCTAATAAC
TCTTTAGTG.A
TTTCTAGAAA
CATTAGTGAG
TTTCTTTAGT
CTTTTCT
GTGTG I -IC
GCTTGTTAT'
CCCATGCGCA
CGCGGTAACT
CAGCTCGGTG
TGTCAXITCT
TTTAGCTAAA
GTTI'TGCCAT
TCTTGCAATC
TGGTGGTTGA
ATTTTATGGG
CTITTTTCTT
ATGTCTTTT
AAT
GCGCTCGCTC
GCTTGTCGTT~
TTAGCTCGGT
CAGTCAGCCG
CCGTTITCAG
TTGTTCGAGA
TTCGGTGGTT
GT.LrT-CTCIT
ATCTCTGGCT
TTCTGCTTTT
120 180 240 300 333 INFORMATION FOR SEQ ID NO:134: Wi SEQUENCE CHARACTERISTICS: LENGTH: 411 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .411 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:134
SS**
S. S
S
S. S 5**S
S
S. *fl.
*5Se 9.55 *5 *S S aS.
ATGCAAAAAA.
CGGTTTAAAG
GCTTCAGTTA
AGCGTGAGCA
TTATITACCCA
TTTCATATCG
TTGG7T17FI'i TGGGCGTFrGT
AGGGCGTTGT
AAGAATTGAG
TGC'FITrGTT
TTCCAGCCTT
C'FITGCCAAC
TCATGTrTT CTCTrATTCC TTTGATrGTG
TGGGGTAATA
GTTTGGGGCG
AGATGGGGCG
GCCCATACAA
AGGGC T.r"r
GTGTTTCAAG
GATITCTTTAA
GGCATrGTGG
TTTATCTA
CAAATGCTAG
AATGCGTTGT
AATGACATTA
.CGTGAAAA
GGCGTTTGAT
GGGCGTTAAG
TCAATCTAGG
GGGTCGTI I-
GGCTAGTGGG
CTCGT1'TGCT
GGCTTTGAGT
TATGGGGAGC
CCATGCCAAT
GATTTAA).T
TAAAAATAT
GC3TGGGGTTT
A
120 180 240 300 360 411 INFORMATION FOR SEQ ID NO:135: SEQUENCE CHARACTERISTICS: LENGTH: 372 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: Misc feature LOCATION .372 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:135
GTGATGGCTT
GTTAA.AAGCG
AACATGATCA
CACAITGCTA
GATGGAGC-GG
AAAAAGCTT
ATTGAGTCTC
TGTTGAAAAT
TTGTGTTGCC
CCTTGCTTCA
TCAATTGGGG
TCTTTATTAA
TAGAGGACGC
TT
TAGTGTGGTA
AGGAGTGGAA
GGCGGGAGTG
TTATGCAGAA
AAAAGGATCA
AAGCTCTGAC
G'ITCCTGAGG
GGGGAATTTG
GTTGAGATTG
GTTACTAATG
GATGACAGAG
AGGTTAGCGG
GGGAAG=rIA
GGGTGCTTTA
AAACCGAAAA
AACGGGTGGA
ATGATG CTAT
TCTCTAGCGT
TACAGGAGAG
TGGOCATAGC
CCAAAAAGAG
TATTTTAGCC
CTCTAGGGCT
GCTGGCTAAG
120 180 240 300 360 372 INFORMATION FOR SEQ ID NO:136: SEQUENCE CHARACTERISTICS: LENGTH: 258 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .258 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:136 0 0**9 0@ 0 0 0*9* ~0 00 0
S.
S.
S S 5
*OSS
S
S.
S
*5 S
S.
5.05
S
*5S*
S
S.
5
S
ATGTATTCCT
TTI'ATCGACG
TATAGCGATT
TCCCATGCGA
ATATCACAAG
TGCTCTTAGA TTTGAATAAA AAGACCGCTC ACAAACACAT CAAAGAAAAG GGCTTGACCA TGGAAGAAGC GATTCGTITA AAATGCGAAT TTIGTCCAAAA CGCATCGCTG GGCTIGATTT
CGATCAT
rI'TTAGGCAC
CGCCCACTCT
ACTTCATTAT
CGCTCTTAAA
AAGAGGGT
TTTAGAGCTI'
GGAGGTGAGC
ATTCTCACCA
INFORMATION FOR SEQ ID NO: 137: SEQUENCE CHARACTERISTICS: LENGTH: 324 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: No- (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .324 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:137 ATGAAAACGA ACTI'TTATAA AATTAAATTA CTATTTGCTT GGTGTCITAT CATTGGCATG ITIAACGCTC CGCTTAACGC TGACCAAAAC ACGGATATAA AAGATATTAG TCCTGAAGAT ATGGCGCTAA ATAGCOTGGG- GCTTGTTTCT AGAGATCAGC TAAAAATAGA GATCCCTAAA GAAACCCTAG AGCAAAAAGT GACCATACTC AATGACTATA ATGATAAGAA TGTTAATATC AAGTITGACG ACATAAGTT AGGGAGTTTC CAACCTAATG ATAATCTAGG TATCAATGCG ATGTGGGGCA. TTCAAAATCT TCTM INFORMATION FOR SEQ ID NO:138: SEQUENCE CHARACTERISTICS: LENGTH: 720 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .720 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:138 6*o@
S
**OS
*q 0SS9 S S SS S
S@OS
S.
S S S S *5 5 e5
S
5* 0O 00e S
ATGATTGATA
'FTGTGTTTAG
AAGCCATGCT
GGGTTGAAAG
GCFI'TGGAGG
AAAAAAAAAG
ACTTATAAAG
AGCGCTCATG
GATITTCT'
GCTCATGAAG
CAACCCCTAT
GATTATTTT1A
SCCTTGATGG
GAGGCGATGG
TTGGGGTGAG
ATTTCTTACA
GCCGTATTGG
CTTTAGGGGT
GCGATGGGCT
GGCCCATTGT
TAACGCAACG
ACGCTCTTGT
ACATTCAAAA
AAGTGCTTAA
GGCAAAAGAT
CACGATTTIA
GATTGGGAAT
AGATCTCAAG
AA.ACACTTCT
?I'TAGACATC
TATCA'ITGCC
GCATGCITTTA
CCC'TTAGTG
GGT1'ATTGAT
AAGCCCCACG
AGAAAAGCTG
GCACAATTGA
GGGGCTTTAA
TTAGGG TI-"I
CAAAACAGGA.
?I'ITATGCGA
AAAGCGTGCG
ACGCCCCTAG
AGCCAAAGCT
TI'AGGGGCGG
GGGCAAGCCA
ACCACCAAGC
TTATGGGGGG
TAA.AAAAAGC
GAAkTGACGCA
TGAGCGCGGT
TCAAATTIAGA
TCAATGAAAT
CGGGCCATAC
GCTCAACCGC
ATATTTI'AAC
AATTTTGCTT
CCTACGXTT
TCTI'ACAAAA
AAAGCCCTAA
TTACGCGTTT
TGCTCACAAT
TGAATTGAAC
AGAGCATT'G
CGTGATCGCT
GCCCTTTAAC
TTATAATTTG
GCCCTTGTGC
GAGTTTT'GC
AAAAGCCAAC
AAAT1'CAAGG
CAAAAAAAGA.
120 180 240 300 360 420 480 540 600 660 720 INFORMATION FOR SEQ ID NO:139: SEQUENCE CHARACTERISTICS: LENGTH: 549 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION I1.. .549 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:139
ATGATAGTGG
GTGCAAGGGG
GGCCAAAAkAG
GGGTTTTTAG
GGGGGGCGTA
ATCGCTACTA
GATAAGATCA
AATGAAGTCT
TTAAAAACC C
CTGCGCTCT
GTTTGATAGG
'ITGTI'TATGG
CGCGTTTGAA
AAGAGAGCGA
TCGCTTTAGC
AAGAAGTCAA
TGGTGGATT
TTTAGCCCT
TAAAACCCCA
GGTTGTGGAA
GGTGCAAGT'
AATCTI'ACAA
AAAAATI'CTC
CATTCTTTCA
AAGACTCCAG
GATTGGCTI7
AGAGAGTT'G
TCTCAGCATA
AAAATCTCTG
TCTATGCGAA
GTGATTAAAG
TTTGAAAGGC
AGCTTTTCGC
CAAGTCCCAG
TTCATTCAAG
GGCTTTAAAA
GAGGCAGCGA
CTTTAGAAGC
CGGCTGCTT
AAGATGCGCA
'I i "IGAAAAT
CGAATGAATT
GCATAGGGAA
ATGAAAACAG
GCGCTGAAAT
TTAAAGAAGC
GCATATAGAA
GCTCCAAACG
TCTTITATAC
CAATGGGGTA
TGAAAACATT
AAAGCTCGCC
ACCCGCGCGC
CAATCCAGTT
CTTACAGCAA
INFORMATION FOR SEQ ID NO:140: SEQUENCE CHARACTERISTICS: LENGTH: 462 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscjfeature LOCATION .462 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:140
GTGGGGG;TT
CAAATACGCA
GCCTCTTCTT
TTGTTGGACG
AAAAATGACG
ACAGACAGCG
A'ITCAAAAAA
TTGTFI'GTCG
TGITRGCGT
TGCAATACAC
TAGAGCCTT
CAGACAACAG
CCT'A.ATCAA
CCCCAACTAA'
TCTITATCCC
CGCTAATAGC
GTrTrTCTT
CGCTGATGCG
AAAAATCTTA
AGTCAAG=,T
AACCCCTTAT
CCGCTTAGGG
CCTI=ATAAA
C ATGTC7
TATGCGAAAA
ATCGCTAAAA
GAAGAACGAT
TCTAATATCG
TFI'GCGCTTA
GTTTCTAAAA
ATGATAGGCT
TATAAAATCC
ATAACCITIT
GCCTTTTAGA
TCAAAAACAC
G3GGTGTTTGT
AAAAACAGGG
TCATTATrGC
ATGTGTTTTT
CA
GGAAAACACC
ATTAAATAAT
CCCCTTTGT
GGCCTCITIT
CTITI'ACCTC
AGALAGAAGAA
GGGCGCGAGT
INFORMATION FOR SEQ t N:::141: SEQUENCE CHARACTR:7r-S: LENGTH: 864 hase Fairs TYPE: nucle:c acid STRANDEDNES'S: =:ble TOPOLOGY: c:rc-.Ia: (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .864 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:141
GTGGTAATAA
CAAAAAAAAG
GATTATGAAG
GAAAGAAACG
TCCGTGATTI'
AACGATCCCA
AAGCCCAAAA
CCCCTAAAAA
CAA.TCCAAAG
ACTTTCACTT
TATGTTTATA
ITAGAAAAAA
ATTTCAAAGT
AAAGCCATCA
TTTTTAGAAT
TGATTTI'AGT
CCCAAGAGCA
TCTTTAGCGA
CTTTTT1'CCA:
TACTGAATGA
ATAACAATGA
GAAAAACAAA
ATGGGGATAT
CCTTGAAGCG
TTAATGACAC
CCACCAATAA
AGAGCGATAA
GTCAAATGGT
GTATTGATTT
GTICTTAAGGA
CTGCTTTTTA
AGAAAATGAC
AACGATTTTT
ACTGACTAAA
GCCAAGCGAT
AGACAACGCT
AA.ACCCAAAA
TATCATGAGT
TTTTTTAAAA
TAA.AACGCAA
CGGTAGCTTG
TGITI'ATACG
GTTAAAAAAG
GGATTTTAAA
AAGT
GCTTGCTCGC
GGCTCTAAAC
TTACAAAACA
GATGAAGACA
AATAGTGAAA
AATAATAGTC
CTCATI'GAAT
AAAGAAGGGG
GATCAAAACG
ATCGCGCAA.A
AGTTTAAGGC
ATAGAGAATA
CATI'CAACCG
AAAGAGCGCT
AAGAGAGCTT
GCCCCAGCTA
TGGTGTATCA
AT-rCTTTTAA
AAAACCTACT
AAAAAAATCC
ATTCCCAACA
ATCAATGGTT
ATAAAGATCG
TTAAGGGCAA
CYTTTTATGA
AGGCTTTAGA
ATAAATTAGA
TTAAGAGCGA
TATCAAAATG
TGTGGATI'CG
GCCTATAGAG
CCCTGAAAAT
CTCATACCCA
GITCCTITAC
AGATTTCTAC
GATAGAAATC
CCAGATCCAA
AATITCTTCG
ATCGTTTTTG
TACTATGGAG
CAGCCAGCAT
TACGGAACTC
S
S. INFORMATION FOR SEQ ID NO:142: SEQUENCE CHARACTERISTICS: LENGTH: 1260 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANT I-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1260 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:142
ATGGCCGCTC
GCTGTCATAG
GCAGATGGGC
AAAGGAATTG
CTITAATCC
ACC7'I 5
FTAA
TCTGATGGTT
GAAATTITG
TATCAAACAA
GCTAATATT
TICAAAATTA
ATTTAGGAT
TTAGAAAAAA
CAGACTAGAG
CCTTTGTTGT
GGAGGGAGCA
ACATTTATTC
ACGGATGCTA
ATAGCTGGAA
AAAGACGCAA.
CCTGGTGTI'A
CACTACITGC
GAGTGGGTGC
TTTATAGTGA
GTGAGCCITI'
TTITGTATI'C
TGCTTTGT
CTAGTAGCGG
ACACGCCTGC
ATAGTGCAAG
CATTCCATGT
ATAATGGACT
TAGAATI'GT
TTATT1TACT
GITITITAGT
TGCTATI'AGT
ATGAAATAGT
AAAAAGTCCC
AAAGCTTCAT
GTCI'AAGAG
AATCTACGAT
GAGTGGGTGT
TCTGCCCTTT
TTACTTGTAT
AATI'CTTGGG
AGCCAATGT
CrFI'AAACGC
GTITGTAGGA
TAATGGTCGC
TAACTI'GCTA
AGAACACAAG
CAGACAAAT
ATCGCTAAAA
TTTIATTGTIC
GTCTITGGTT
GTC'ITATGTG
GTTATTCAAC
GGCTAAATTT
CGAAATGATT
ATATCAAGGT
TGTGGGTCGT
AAACAGCACT
GGAGACGAIT
CTTrCTA.ACC
CCCAATAAGC
T^I'TCATTr
ATCCAACCTT
TATCAAAACA
TACCTTTCTT
TCCAGTI'rITG
AATGCTGGGA
AATATAGACA
TIAACGAGTT
ACCCTTATTG
AAAGTI'TTCT
ATTTTCATGC
AAAAAAArA
TCTTTTTGCAT
GGCATI'ATTG
AACGCTATCT
GTGCAA6ATGG
TCAGCATTIG
ACGGCTAACA
GAAC'ITCCCA
CTITTAGTGCT
AAGATTCTT
CGTITTTCTAG
TTGGTATGGT
ATGATTTAT'
TGTACCATTA
CC=rCAAAA
TITCTAATGT
CGCACCACAG
TGAATAAACT
CAGCTGITTT
GTTATGTTrT
TACTGCTAGG
TrCATTGAC
TACAATACGC
TAGCAATAGG
TTGGCACACA
CTAGTGCTGG
GTAGAACGCT
TGAGAGACAT
AGTCTCATAG
TGGTGCTTTA
AGTTGTGCAA
CAAGATCTTG
TTTAGGAATG
TGAAATCAAA
TGCTTTTAAA
TCATGTAACA
GGTTAAGGAA
TATCACTAAC
ATATGAAGAC
G'ITAITAGTT
TATGACTTAT
GmTI'CAG
TTFFACATG
AATCAAAGTG
AATITCACTG
AGGTGGTCTA
AGCTGGAGCC
AGAAGC TTAT
GCCAGGACAT
AGCTAGCAAA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 INFORMATION FOR SEQ ID NO:143: SEQUENCE CHARACTERISTICS: LENGTH: 216 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .216 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:143 GTGTTAAAAT TTCAAAAATT ACCCTTATTG TTG TTT CCA TTATTGGCTT TTGATTATAA GTTTAGTGGG GTAGCGGAAT AACCATTCCA AACTCAATFIC CAAAGAAGGG'ATTTCCCTA ACGATCAAGC TTCAAGTGRA TTYCAAATCT GCTCCC TTCTTTATAA TCAAAGCCCT CTGTTTCTAA AGTGGGGTT CAGCCACCTT TGTAACCGCC INFORMATION FOR SEQ ID NO:144: SEQUENCE CHARACTERISTICS: LENGTH: 615 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .615 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:144
ATGGGTAATC
TTAGGGCATA
TI'ATTGTTTTI
TTAGGACAJAA
AAAAAACGCT
TATGGCACTA
AGCAGTATCC
TCCATAGGGC
GAAGGCATTG
TrGCTrIr=r
TCAAGCCAAA
AITTCTAA
TCTGGCGCTT
TATT=ATC
GCACGCAkA
GGAAATACGC
TI'TTAGGTrG
AAGAATCTGA
TTITTAGCGT
AAAAACTCAA
ATOCCATGAG
AGATT
ATTAGGATT
CCCCTATATG
C'ITAAGCGTT
AAATGTAACA
AGGGATCATG
GGTGCTTTAT
ACAAATTTT
TTTATTCATA
TI'TGGTITI'A
CATGGATTCT
GTI'rrAGCGG
ACTGGGGTGA
GGTGCGGCGA
GAAGCTITA
CTrAITrTCTG
TATTTGGTGA
ACTCAAACT
ACCGGATGGA
ATGCCCTTAC
TTTTCTAAAG
CTI'TAGGGAG
GTGGTGGGGG
TGI'TTATCGC
AAGAGCTTGA
GACCTAAT
GTA'rTAGTTr
TGCAGTCTAT
TGITTCTAG
TCTTTGCCAC
CTTTCCATT
CGCGATAGGT
TGCTTTTGTT
TGAAATGCTA
CATTAACCCT
ACTGACTTTI'
TAA'ITTGCCT
AGGGTTACAA
GGGGATTAAA
I'r=rIGGT CATGTTGA'Fr 120 180 240 300 360 420 480 540 600 615 INFORMATION FOR SEQ ID NO:145: SEQUENCE CHARACTERISTICS: LENGTH: 984 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .984 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:14S .0*
ATGGAAAAAG
GAAAAATATG
C ETGAAGAAC
CTCAATGGAT
TTATTTGATG
TGGATTTA
GTATGCTTAT
CAAAATTTTG
AGACAATGG
AACGAAATAG
GAAAAACTGG
AGCATTATCA
CTTTTI'CATA
TITGAACCTA
ACAGGTTATG
AAAGATGATG
CAGTATAAAG
TTTGCGTGAG CGCATGGGGG GCGATGATTG GGAAAAACAT AAGTCAAAGC TAAAGCCAAA TTFTAAAAAA AGTTITA AAGTCAAAGA AGCTGATGTG GCAGTGCGGT GTrCTTITTT TGCCGTTAAA AGAAAAAGTG CCATAGTCCA AAGAGCAGAC TAGCGTCTTA TG'ITAATAAT CCCACGAAAC CATTAGGTTG TTT CTTATGA GCATAGCATT ATATCGCITT AATCAGTAAA AAGAAAhAGIT AGAAAGCGAA TTGAAA'ITGA TACAAA;ATCT ATGTAACTGA AXVFGZCGATr GTGTGAAATC TAGGAIT"ATC ATGTTAAGGA GCAA
TTGCCTAAGA
GTTAAGGCTA
GAGCAACA.AA
AAAAAGCGTG
CTTITTTCAAG
GC-TCTAGCCC
CCTTATTTAG
AAGAGCATCC
AGAGAAAATA
CAAAGCGCAT
TACACTAATA
ACCCAAGCCA
AAGCGTTATA
G'ITCCCCTAA
TTAAAAGATT
CATGTCGAGA
TTTTAGAAGA
AAGCAATAAA
AGACACAAAG
ATATGTTACA
CAGAGCGTAA
ITATAGAAGC
TAACCTTrI'C
GTGCTAATCA.
TTTCAAGTAT
TTGAAGTGTG
TAAATCTAAC
ATATTGAAAT
GAATAATTAT
ACCCTACAGG
TAGATGAGAA
AAAAAGACCC
AAGATTAAAA
CGAAGAAGAG
AGAAAAAACA
AAGCACTATG
AATI'GGCGAT
CATI'ATTA'T
AAACGCTACA
AGCGCTTGTG
AAAAGAGCAA
GAT1-171771
ACGAAAAATT
ATCCGCACAA
GACCTTTGAA
CTTTATITGTT
AAATAAAGTC
TCATATGAGC
INFORMATION FOR SEQ' :D SEQUENCE CHARA77F~f7.CS: LENGTH: ZZ: ase pairs TYPE: nudle:: azid STRANDED!:EZ:z azuble TOPOLOGY: 7rua (ii) MOLECULE TYPE: -DN~A ienomic) (iii) HYPOTHETICAL: N3 (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .228 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:146 ATGCTGCATA AGGCTAAGGT GGGCATCGTG TTTCAGGCGC TT1.TTLATTGT TGTTTrACTT GAGCGCGTTT TTAATGGTGG ATGTTT-ATAA GCGTTTTAAT AGGGAGCGTG GTGTTCCTT GTAGGG TTT A AAAATATCAG C=,rGFFITG GATATTGGTT IrTTTAGGGAT TrITTTGCGTG CTTTTAAAGA CACTAAACGC GGAGCGATCT ATTGGTCTTr
ATGAAATC
INFORMATION FOR SEQ ID NO:147: SEQUENCE CHARACTERISTICS: LENGTH: 420 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: H-elicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .420 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:147 a an.
a. a
ATGCCGTTTT
GCTAGTGGGG
GAGAGCAACG
TACGGCXTr
AAAACACGCT
AAGGGGCTTA
TTAATGCTCT
TGAAAAACTG
TGGGGAAAAG
CTTCAAACAT
TTAGAGAAGA
ATITTTTAAA
'ITAAACGCTT
CCTATTAGA
GATCTGGAGT
CGTCCTI'ATI'
TGAAGTGGAA
TGAGCATGAA
CCAAACAAGC
ATCTAACGAC
TGGCTATATC
TI'AAAGATGG
GCGAGCCT1TT
TTGATCGCGC
CCCTI'AGTI'A
CTATCTAAAA
AGATTCAGCC
CAAAATAAAA
CTTITGAGCGC
TAGGGGCGTT
CITrTT=AGA
'ITAGCGTGAT
ACACGCTCAA
AGAATGAACT
ATARGCGTTT
GATTAGTGGG
TGGGCTI'AAA
CACGGAAGAA
TAAAAA.AGAA
AGCGTI'ATTA
CAACGATAT
AGCCCCC?1'T INFORMATION FOR SEQ ID NO:148: SEQUENCE CHARACTERISTICS: LENGTH: 924 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .924 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:148 ATGCCACAAA ACCAGC1-rGT GATCACCATC ATTGATGAAT CAGGCTCTAA GCAACTCAAA TFF=CTAAAA A'ITTAAAACG CAACCTCATC ATTTCTGT1'G TCATTC'I'I1 ATI'GATCGTG
GGGCTTGGCG
AGGAATGCGG
GAGATTAAAA
TCCITGAFTG
TT1AGAAAATT CCC CTAAAAA
ATTAAGGGCG
AGCGCTGATG
GTGCGCATTG
GTGCAGCCTA
AATAGCGGCG
GAAAAATTCC
ATTGAATGGA
GATAAAGACA
TGGGGTTTTT
TITTAAGGGA
ACAAGCGAGA
AAATCAAAAA
TGAGCTTAAA
C'ITATAGCGC
TTGAATCCGG
GGATTGTGGA
AACATGCGTT
AAAGCTTCAT
GCGAAAAATT
TAGCATGGGA
AGAATCTGT
CCTTAAAAGG
AAAA~TTT=A
TTTTAGGGGT
AGAGCTTTTT
GGGGGCTAAT
TCAAAAACAT
TATCAAACCC
GATCGATTT'
TTTTGTGAAG
TGGTF1'CAGC
CCAA.AAAGGG
GCATTATGAA
TTTGGATCAT
TTGGGTTTTA
TCAG
ATCGCTAAAA
TTGTATCAAA
ATTGTGGGC
GGGGGAGGGC
TTAGCACTCA
ACTAAAGAAA
ATCGC-GCCAT
ACTCGTTCTA
TCCA'FrIATA
CAGTTGATTG
GTGCGGTTTT
TTCAAAGCG
TGGATACGAT
AAAATTACGC
AAAAGATCCG
ATCTCTATGA
TGCTCATTCC
GGAACCACCC
TGAACACGCC
ATGCGGGGTA
CGCACTTAGA
GCTATAGCGG
TGGGTAAAAT
CTI'TAGAAGA
GACAAGCGAG
CCTAGCGAAA
TGGGCTAGAA
TGAAGTGGAT
TAATGGCATG
CAITAAAAAG
TGTGTATGCG
TGGGAACTTG
TCATGTCAAT
GAAGACCGGT
TTTAGACGCA
AAATAAAT'TT
AGAGCATGTG
GAAGACATCG TCCAGCTCCA
S.
S
S.
5 9 p INFORMATION FOR SEQ ID NO:149: SEQUENCE CHARACTERISTICS: LENGTH: 1017 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1017 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:149
S
S S a
ATGATCACTG
AACCCGTITT
GAAATAAAGC
TATTTGATCA
GGTAATGGCG
AGCAGCCTTT
GCGAAAAACT
GCTTTTGATG
GATGAATTAG
ATCGGCGAAG
CTCATGTATA
TTTGCGGCTG
GCTCT'ITACG
GAAAACACCA
AGCGAAGAAG
AGCCA'ITTCC
CATGGCTI'G
GCTCTCACAA
ATGGCAAGGA
CCCTAAAAGA
AGGATTrI'AA
TGGGGGCGTT
ATAGCGATCC
TAAAAGACTI'
GCGATGCGGA
CGATITATT
TCAAATGCTC
AAACCGGGCA
AAATGAGCGG
CATGTTAAG
TAAAAACCT
AAAAATTTGA
CTACAATCAA
GGCTTATTCG
CCCCAAAGAA
CATTCAGGCT
AACGCCAGAG
GCATTTAAAA
AGGA'ITAGAG
TGATGGGGAT
AGAAAAACAC
TAGGATTGCG
CGCTAAACGC
TCAAGTGATG
TAGCAA'PITA
GCATATCTI'
GGCTrGGAG
CCCCTATTCC
AATCA'ITCGC
AGAAATCATC
CGCAAGCAAC
TACAACGGCT
TI'AAAAAACA
AAAGTCAATG
AATCTTAAAT
CCGATITA.A
TTITCCTAACC
ATGCGAGAAA
ATGCTAAGCT
TTGCATGCTC
TATAACGCAA
AAAATCAAGC
'TTAAAGAAC
TTATTGCTTG
TACACCACGC
AACTI'ACAAG
AGCATTGATG
ACCCACCCCC
TI'AAAATCAC
CGCITTTAAA
CCCTAGAAGC
ACAAAATCGC
AGGCTTTAAA
ACCACCCAGA
ACGCTATT
CTCATCATAT
AAGGCATCAC
TCAATACTTr
TCAAAGAAAC
GCTATTITGG
AACAAAGTCC
CTGAAGAAAA
AAGCGCTTAA
GCGTGAGAGT
TATTI'AGTCA
GCTCAATCAA
CGCAAAGCAT
GTATCATCGC
CCTGGAT rrl
CATTGATTTT
CCCTAGCGAA
AATAGGCI'IT
CTATGCGGGC
CCCITTTGTG
TGGTAAGACG
TAATGCGCAT
CTATGATGAC
AAGCGACTTG
AATCGCCGTG
AAACCCGCCA
GGTIrTGAA
GCCGCI'
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1017 INFORMATION FOR SEQ ID NO:150: i)SEQUENCE CHARACTERISTICS: LENGTH: 621 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 6~21l (xi) SEQUENCE DESCRIPTION: SEQ ID NO:150
ATGTCCAAGA
ATAAGGGAGA
AGCATGGCGT
AGTAGCATGG
GTGCAAATCA
TTCAACTCCG
TCATTTGGCG
CTTI'CTAAGC
GGTTATGTGC
GTCGCTATGG
CAATTTATAA
ACCTTCAAAA
TGAAAATGTT
TAGTGGTGAT
TTTTTATTTC
CGGTGTATGT
CTGCAGAAGT
TGGCGCTGTI'
AAGTCAATTIC
TTTTCACCAA
TTGGAGGCAT
GAAGAATCCA
TGAAACCAFr
CACAACCACA
TGCTI'TTTTC
GGGTGCGGTC
AGTTGAACGC
GCTCACCTTG
CAACGCTATT
TTACCTCATT
CGCTACAGG
AAGAAGAGTT
GCYTTTTATT
AATATCCTCT
TI'TTACTGG
ATTGTGATGT
AAGCAAAGCC
ATTTTAAGCG
GATGCGCAAA
CCCTTITGAAG
ATTCAAAAAA
TYCCACAAGC
TCTI'TGCGAT
ATOCCATTAC
ACGCTGAGTT
ATGCGTTTGG
CTAAAATCTT
CTCCTAGCAT
TYCCYAACAT
CGGCGGCTT
TCCATGGGAA
CCAGAAAGCC
CCTTACTTTA
CGCTCTCGCT
TTGGGCGTG
CATGATGTTT
GTGCGTTCTT
TGSSGAAAAC
TAAAGCGATT
AATGC'ITTTA
AAATCACACG
o a a.
a a.
a a a a *Oaa a a.
AG GAATCTCT A INFORMATION FOR SEQ ID NO:151: SEQUENCE CHARACTERISTICS: LENGTH: 753 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .753 (xi) SEQUENCE DESCRIPTION: SEQ ID .1.
0. a
ATGGGTGCAA
GCGCTXTT
TCAAAAAATA
ATTATFI'CTA
ATATrCTTAT
GCTI'CAAGAC
GCGCTCAATA
TTTTCAAGCG
GAACAAAGCA
CTT'GTTC
TITTACTACC
TTAGCAACTT
CGCATGTTAC
'TIATCTAT
GGAC TFTAT
CCACTGAAAT
GCGCGATCTT
TCTACATGCT
TAATCGTI'GT
TCATCACTAT
CATTGTIITG
TCTI'AGGATr
CTTTAGAATA
TTAATCAACT
CAACATrTI'
TAACACCAAA
TTTI'AAACTT
TTATCCTATT
TTTTTACTTT
TGGTCTCACA
ATCACCAGCA
AATCCTATAT
TC'FrAATTT T?171.7GCTITG
TTGTAATATC
CCTACCTAAT
TCTAATCAAA
CA'ITATTGGT
AGAACGCATG
GAAATCAAAT CTTATCTCAC TTAATGCTCC TATTACTAAT AATAACATTA TAGGTCTAAT CAAGCTATAA CAAGCTCTAG ACTITCAAAC AAATAACTCT GCTTrTATCT TTATTGFI2CT AAAGCGC'ITA ?I'TTGGGGTT GCAATTrro TAGCTAGAAT ATCAATCTCT ATGCGCTAAT ATTGGTCAAT TAT1'TATCAA GCITITCAAG GGAI'rG ATAC GGCATAT TATrTTTACT
CGT
CAATACAAGC
GGGACTTCTT
ATCGCATAAT
AGCATI'AATC
CTCTTTI'TAT
TATI'AGCATT
TTTTCAAAAC
GTCTTGTAAT
AACATCTATT
TATACTGGTT
AAGCGCTAAT
INFORMATION FOR SEQ ID NO:lS2: SEQUENCE CHARA~CTERISTICS: LENGTH: 207 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .207 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:152 ATGGCAGGCA. CACAAGCTAT ATATGAATCA TCTTCTGCAG TCAATCATCT CAAGCACAAG TGGTGTCGCA GGGCCA TTT G ATGACAGCAG CGATTATTCC TATTGTTGTG GGA TTI'ACTA ATIRACCCAA TAYAATCAAA GCATCGC GATrCTTATC GCAAGTCTCC CAGGAATAGT AGCGGGCGCT ATCCGCAAAT GACCGYTATY INFORMATION FOR SEQ ID NO:153: Wi SEQUENCE CHARACTERISTICS: LENGTH: 336 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 336 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:153
GTGAGCCGTA
CGCATTCAAG
AG CCAAATTA
CCTCTAACCC
AAG CTCC CC C
GCGATGATT
TITTAGGCTT
CCCCTATCAA
TTTATITAAG
TAGCTITAGG
ACTTGCTCAT
TATCCTI'ACT
GAGCGATGAT
AGGTAAAGAT
AGAAATTTTA
CAAAGACATT
CGCCGGCACG
TT~ATAAAAAA
TTAGCGATGA
GTCGTIGGTA
GAAAGCGAAT
GTGGGTAACC
ACAGGGAGCG
CCCCCC
CTITATGCGC
ITGAAATCCC
TGITI'CAAAA
CTTTCATCAC
GTAAGAGCGT
TGAATCCATC
TAACAGCCAA
ATCCAGCTCG
GGATTI'AAAA
GGGCGTGAAT
INFORMATION FOR SEQ ID NO:154: SEQUENCE CHARACTERISTICS: LENGTH: 456 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .456 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:154
ATGGATGAAA
GGCACTAACG
ATTGACGCTT
AGGCCAAGCG
FI'TTGCGCTC
CAGTATTTCA
ATGCAACAAT
GAGATTTIAG
GSCTCGITI'A
TGAGCATCAT
CCAAACTCGG
ATATGGATTT
TGGTTTCTI'
CTATAGAAGA
ATTCAAGCGA
AAACTTTAAA
TGGGGTGATT
CTTT7TTT7"CAA
CGAAGAATAC
GATTTTAGAA
TGATGAAATT
CACGAGCGAG
ACTAGCGAGC
AGGGGTTAGG
TGCATGCCCA
AAAACGCCAA
ACCGAAAACA
ACITTTCCAAA
ACAGAAAAAA
ACAATCAGCC
CTITITTGATG
TTGAG
GTCAGGTTTT
GCGCAAAGGA
AAAACAAAAA
A'TAAAGCCCC
ATTATTCTCT
AAGCGGAGTT
AAAGCCAAAA
TGCCAACACC
AGTGATCTTG
AACGCGCTTA
A.AAATCGGAT
AA.ACCCCGGG
TGAAAACTTG
TTIGCAACAA
INFORMATION FOR SEQ ID NO:155: Ui) SEQUENCE CHARACTERISTICS: LENGTH: 339 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .339 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:155
ATGAGAAGAA
GAGCATGGGG
ACGGATTGGA
AACCGATTTIA
ATTACGACTT
TTGAAAGAAA
ITATTAAAAA
TGGAAGCTTG
ACATGCCTGA
AGGAAATCCC
TAAAAGCGGG
AATTAGAGGT
CACACTTTCA
GGAAAAACTA
AATGAACGGG
TATCXITATG
CGTGAATAAC
TGTITTAGGG
CGC~T AGGCT
GACGCTAATG
TTGGATCTCG
ATCACCACAG
TACATTGTGA
ACAAACGAT
ATGAAGATGT
CGGACACTAA
TAAAAAGGT
AGGGCGGTAA
AACCTT~rrAC
TFI'AGAAGCT
GGTGCTTATI'
GCGTGCGGAT
AGCTGAGGTC
CCCCCAAGTT
INFORMATION FOR SEQ ID NO:156: SEQUENCE CHARACTERISTICS: LENGTH: 549 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANT I-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .549 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:156
.ATGGCAGAAG
7= GTCATTA
CTTATGGGGA
GCTAATCCTA
TTGGTGCTTG;
AATGGCAGAC
AATGAAGTCA
AA.AAGCGTGG
AGCCAITTGA
ATTATCCAA
AACAAGAAAA
TTGGAAGCGT
ATAAGGAAGA
TGGCGAACAA
GGCCTTTGTA
GCTACCTTAA
AGGTTAAAGA
AAGAAGTG-T
ATTCGTT
TACCGCGCAA
GCTAGTGATG
ATCTAAAGAA
GAATCAAGAA
TGCGATI'GAT
GGCTTCTATr
CACGGCGATT
TACTAACAAA
GATTGATGGC
CAACCCCAAA
CTTITATI'GG
AACGCTI'CTA
GCCAAAGAAG
GCGCCTTI'G
TCGCTAGAAT
AAGGACACGA
GGCAAAAACA
TTTATI'AAAA
AAAAAAGCAA
TGGGGGTGAT
AAAACACCCA
GCTCTAATAT
CGGTGAAITT
TGAGCAATGA
TTATAGAAAT
AGCTTAAAGA
ATGTCTTTTT
AGCCCTI'TTA
TATCATGCTG
AGAAGTCCAA
CCAGCAATAT
GGTCTCTCAA
A-AAGCTI'?IG
TCTATCGTCT
TGAAATTAAG
CACTGATTTC
120 180 240 300 360 420 480 540
S
S.
*5 S S
S
*SS~
*4 S. Sq S.
SSS*
S 9 INFORMATION FOR SEQ ID NO:157: SEQUENCE CHARACTERISTICS: LENGTH: 105 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAHE~/KEY: misc-feature, LOCATION .105 (xi) SEQUENCE DESCRIRTION: SEQ ID NO:157 ATGGGGTGTT TTAGCACCAT TIGTTGTAAG GGTFITAACGC TTAGCGTTGG TGGAI'I'TTG GTGATGATGA GATTC'ITAAT ATCAAAGAT TTI'GCAAAG A7I~ INFORMATION FOR SEQ ID NO:158: SEQUENCE CHARACTERISTICS: LENGTH: 2106 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular 202 (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .2106 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:158 9**e 9* S 9
A.
9 9.
9* Sq 9 9
A
9 9.
99 9 9*99 t *499 9 *999 "9 9 4
GTGGCGCGTC
TCTCAATACT
TATITI'G
TCITTTCATGC
TTGCAAGAAA
AACTCTAAAG
AA.ACCCCTAG
AAAGATTATT
AAAGCTTATG
ACGCCTTTGG
TTAAAAGAGA
CAAGAATTAG
AAAGCCCCCA
AAAGAAAACT
TTCCCTGAAC
TGTTTGATGG
CCTTTGAGCG
GAAGTGAGCC
GGGGCAACCG
TACCAAAACA
TTvITTAAAG
CCTAATTTGC
CCTICAAGGG
CTTATGAGA
AGAACCTCAT
AACGCTITGA
ATCACCCAAA
GAAGAGTCTA
GTGGAAAACG
AATGGCGTGG
CATAGTI
9 I7r
TTGAAACACA
CCTCTGTATG
GATGTGAGTT
GTCAATAAAG
AAGAGT
TTGTGGTTAA
TGCAAGCGAS
TFI'TAGAAAG
ACGCTAATAG
CITTAAAAAG
AGGT'FFIGAA
TAGGGGGGTA
TCATTCAAGA
AGAGCGAAAG
ATAT1'ATCWT GGGCCAAG7IT
TCAAAACCAA
GTTTGGAGGA
TAGTGGGCGT
GCATCCATT
TGTTTGAAAG
TGTIAAAAA
ATAATAACGC
GAAGCGGTAA
TGCGCCTT
GGCATITACCA
AGAATI'TAGA
ATAAAGAAGC
CCTTATACCC
CTAACCAATT
ATGACGCGTT
ACCCTAAAGA
GGAAAAACGA
ATITGTTAAA
TGGTGTI'GGC
TAAGCAACAT
A'ITTCAATGT
CCAGGCAGGT
TGGAGGGCTT
TGAAAGCG?1'
AAGGCGTAAA
CTTGAATCAG
CACTCACTCT
AGAAAA'TT
CTAGAAATC
TITI'ATGCA
TTrGAGCGAT
AAGCTTTAAT
GATCAC'ITCT
TI'CCATAGAG
TAGCATGTCT
ACGATTATCC
TI'TAGACGCT
TATAGAAACT
AAACCACCGC
GCAAAATTIA
TTTGGATTAT
TAAAGAAATI'
AAGCACGCTG
AGCI'I'TGAC
TGACGGCCAA
A'I=rrGCAA
CTTAGAAGAC
CAAAGA7IT= GGGCT1'GACT
CAACTZCAAC
CTTAGG377 CAGCG7I'T CA7__AAAATC A77~
ATTGATI'ATA
TITGAAAATA
TTGCATGGCG
AAGGATAT'C
CAGCTCAAAA
GAATATATTA
AGCTATATCG
CAAAAAACCT
ATAGCGGTGG
CCTATGAGCG
AATCTTGTTA
ATGCAAAAAT
CAAACCAGCT
TTTGGCFI'GA
TTGCGTIT1,r
GGITTTAAGG
TCCCCTTT
GCCAGAGTGA
ATTAGCTATI'
AGGATGCAAG
TCTTTTAGTA
TCCTITFFI'T
ATGAATGCGA
AGTTTGCTGG
T1AGAGCCGT
GCITTI'ITAA
TTAGCCTATT
TI'GG IIrrv~
AACGCTTTAA
ATTTACCAAC
ATTITTGTATC
GAAACTGAAA
ALATCTGGGTA
ITGAAAATCT
TACCCTACAG
AACAAAGCAT
AAGAAGTGTA
TTTTGGAGCA
TCTCTTATAA
ACTATGCCCC
ATGGGTITGA
CTAGTTCTAT
ATAACCGCTT
GAGCGC TTI
TCAATAAAAC
AAAACGAGCT
TCGCCCTAAA
TAATTTTAGG
AAGGGGGGTA
TAACCTCTAA
CTAATTCATG
TATTCAATTT
ATGGGCATAC
TAATGATGAG
GGTTGTATTC
TCAACCCCTT
TGAGCATGT1'
TTTCTGGCGC
AITITAAAGA
ATTI'GAATAA
ATGTGATAAA
ACrI'GTTTTA
TAGACGAATT
TCACGCAAGC
TTAGCGGGGT
CGCAAAA)AA
TTrCTTTITT ACGGGAGTrC
ITAATTCAGA
AGTGGCGTGA
TCAATCTGAC
TGAGAATCAG
TAAGAAAAAA
AGCGCTT
CAAACTCITA
ACTCCCTT'A
CACTTITGAA
GAT1'GGCATT
ATACCAAGAG
GCTGAGTT
ATTAGAATAC
CGTI'CTTATC
GCTTTTATT
TFITCCT'Fr
AGCCCTAGCG
GGGGAATAGC
CCACAACCAA
TTI'AGTTATA
CGCITIAAAA
T. CACCGAA
TTGTTTAGAG
GGATCTTGCC
GATTAAGAGC
AACGCTTAAA
CCCCCTrTTTT
CCTAGATGCG
TAAGATC'ITA
TAAATCCTAT
CAGGAAAGCT
TAAAAACGCC
CGCTAGGGAA
AGAAAACACC
CAACATGATI'
TTCCAGTCAT
GAAACTTTI'G
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1800 1860 1920 1980 2040 2100 2106 INFORMATION FOR SEQ ID t:0:159: SEQUENCE CHARACTERISTICS: LENGTH: 879 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .879 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:159
ATGCAAGAAG
GGGAATTTTG
GACGCGCTAA
ATITI'CAAAA
TCGGGTAGGG
ACTTCGTCTA
CAAAATTTAG
ATAGAAAATA
CAAGGGAAAG
CTATTAGCCC
GCGGTGGTGG
A'FIGAAGCCA
AACCAGOTrA
GAGGOCAATC
TCTAACGATA
ACTGGCAAGC
CGGTGCGCAT
ATGGGATCAT
TCTI'TGAAAG
TGGAATTGGT
ATTTTGCCAA
AAAAGGCTTC
TCACCACTTC
ACA?1'AAAAG
TAAACGCTGC
CTGATGAGGT
ATATI'AATAT
AAGAAGTAGA
TAAAAATCGC
TTTTIAGAAGA
CGTCCAAGAC
CACGGCTGAA
GSAYTATITG
CTATI'CTGGC
TACTAACGCT
AGATCTAGCG
AAACTCCCAA
CATTCAAGGC
CAITGTAGAA
TATTGAAGCC
GAGGAAGCTC
TCTCGTTCAA.
AGAGATCAAC
TAGCGATTCT
TGTGAATAAA
ACCATTAAAG
CCCGCAAGCC
CAAGAAAGCG
TTGGATITTA
TTAGGGCAAG
AACGATAGCG
CACAAAAGCC
GTGAGCTCTC
ATCATTAGAG
GCACGAGCCG
GCTGAAAGGA
AGCATTTCAG
GC'ITCTATTG
TTAGAAATCA
AAGCAGTTT
TGG=TCAGA
CTGATTI'GAA
TAGGGACTCA
GAGGGCGGAT
AAATCCAAAA
CGAATTTAAA
TGATGGAAAC
AAAGTGAAGC
ATATI'GCCGA
GCGAGCATGG
CGCAAAAATC
ACACGAGCGA
AAGCCTTAAG
GTCAAGAAAT
TGTGAAAGCG
AGAATTGAGA
CATGCCAAGC
CCAAAACGCT
AATGCTAGAA
AGAATGCGTG
TTCCAAA.ACG
CATGATTGAA
TCAAACGAAT
CAGAGGCTTT
CCTCAGTGAG
AAGCATI'AAA
ATCGGTTACT
TGACAAAGTC
INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 156 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .156 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:160 ATGCCTAAAA G?=TCACCT' ACCGACTTTC GTGTGGTG IT TGTTTGTGGG GGTTATCTTA AGGAACGCTI' TGTCGTTTTT TAAAATCCAT AGCGTGTI'G ACAGAGAGGT TTCAGTTATA GGGAATGTGA GC'F'G AGCCT GTTTAGCT TACGCT INFORMATION FOR SEQ ID NO:161: SEQUENCE CHARACTERISTICS: LENGTH: 546 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .546 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:161
GTGGGGCTTT
CAAGACCCCT
TTGCGCTITG
TTAGAAGAAG
GGGGAGCGCC
TTAGATGAGC
TTGAATTTAC
ATCAAAGCTT
GCTATTGAAG
AGGCTT
TAAATTCTAA
ACGCATCATr
CTTACCCTAA
TGTGITTAAA
AAAGAGTGGC
CAACCTCTGC
AAGAAAAGCA
TTI'GCGATAG
AGGTGTTTGA
GGCGT1'CAAA
AAACCCTCGC
AGCTTCACAA
CCCTGAATTG
GATCGCTAGA
TTTAGACAAA
GGATI'TGAGC
GGTGTTAGTG
CAACCCCAAA
CCCTACCGCA
TTAAGCATTC
CAAGAATGGC
CTTAACTTIT
GCGATTGCCT
AGCATTCAAA
TATTTGTTI'A
GTGAGTGAGG
CACGCTTATA
AGATTITGCA
AAAGCATTT
ACCATTTAGC
ACGCTTATGA
TAAAACCTAG
AAAGCGTGFI'
TCAGCCATGA
GGAAAATCGT
CCAAGCGTT
AATGGTGTT
AATAGAAGCT
TGAACTTTGC
GCTCAGCGGA
AATCATTCTT
GGAATTA'FrG
TTTAGATGTG
GGAAACAGGC
GTTGGAATCC
120 180 240 300 360 420 480 540 546
S
S
INFORMATION FOR SEQ ID NO:162: SEQUENCE CHARACTERISTICS: LENGTH: 753 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAM.E/KEY: misc-feature LOCATION .753 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:162
GTGAGITTGA
TCCAI'ITCAG
ACAGCGACTA
GATGTCCCCA
CATITTFAG
TACGCTAAGC
GAAAAACAAA
CATCAA'ITTG
TCTITI'GATG
ACCCAAGCCA
TIAAACAGAA
CTTGTGTT
GTGTTWAAGA
TTAAAGTTAG
GCAAAGCGCG
GAAAAATCCC
TTAAAGATAA
GGGCTAATAA
GAFTGGGTT
AACAATTTAT
GTGGCATGGA
ATAATGAGTT
TGCTGTATTr
CCGCTATGCC
TAGAAATGCT
7-T71TWGAAAA
TGGTGATAAA
TGTGAAAATC
TITTAGTTTA
AGAAAAATFI'
TAAAGTAAAA
AATCAGTITTA
AGAAGATAAT
TT1'TGAACTC
GAGCGAAATA
TTGCTTTTCT
CAAAGAACAT
TAAAATTTT
AATACTTCAA
AAAGTGATTG
AGACATGCCT
AAGCATTATG
GAACTCACTA
ACTCTTTATG
GAAAATTTAG
TTTATGATTA
TCACGCATTT
GTTATTAAGG
ATITTrGGAGT GCCC?1'TTGA
GGACTTTTAA
AAT
AGGTrrCTAT
TTAGCGATTA
TAGAGTGGCA
CITTAAAAGA
AATTGAGCGA
AAAATACTIT
CAAGAGAAAG
CTIATCCTTT
AACAACAATA
TAAAAACCGC
TI'ATCCATGA
GCCAAGTGCA
TCCTTTAACT
TGGTATTTCA
GATCGGTTAT
TGAAAAATAT
AATGAI'TAT
AAAATTTTTA
AT?1'AGATCG
GCTCATTCAT
TGGCTCTAAA
TACCCCCTTA
AACCAACGCT
CCATAACGAT
120 180 240 300 360 420 480 540 600 660 720 753 INFORMATION FOR SEQ ID NO:163: SEQUENCE CHARACTERISTICS: LENGTH: 120 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .120 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:163 GTGATCACGO CGTGTTITAA TAGYGAAA.AA ACCATTGAAG ACACCATTCT TTCCGTGCTT AATCAAACTT ATAAAAACAT TGAATACATC ATTATAGATG GGGCTAGCGC GATAGCACTT 120 INFORMATION FOR SEQ ID NO:164: SEQUENCE CHARACTERISTICS: LENGTH: 366 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: He1i-cbacter pylori (ix) FEATURE: NAME/KEY: mi~s:_ teature LOCATION .366 (xi) SEQUENCE DESCRIP::::; SEQ ID NO:164 GTGTFI'GTAG GGTTAC ATCTTTGA'Fr TAAAATTTGA AGTCTATCTI' ACTATGCTAA TCTCTTIAAT G==7Z; GCTACGATI'T ATATCAATTT CCCAAAAACC 120 ACAGAACT CCATGCT TGz3;Z;%. CCTATGTA AGATTAG ATCTTAAA 180 ATTIT1'AGCA AAGAGGGCTT TrTAZZGTGCATAGAT TAGGGGTGCA ATI'TGATAAT 240 GGCTTTATI'C TAGGTAAAT TGG7._A AAGCFI'AGAA ATGTGTGCTA TGACAAGCCC 300 TITAGGAACGA TGATTGTI'GC ACCCCCTGOT GCGGAAAAAC TGCATGTGTG GCTTTGCCAA 360 A'FrTAT 366 INFORMATION FOR SEQ ID NO:165: SEQUENCE CHARACTERISTICS: LENGTH: 339 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .339 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:165
ATGAAACGCC
CCTAAGTGGG
GAAAAAATTT
TCCTCAGCCA
GAGATTAAGG
CTAAGAATCA
11TGCTGTTGC
CAAAAGATTG
TAGTGTGTGG
GACAAAACGC
CTGGTGAGCT
CTAAGAAGCA
GCI'ATTTTG
CTCAAAAGAG
GATGAGCGAT
CTrAGAGAAA
AAAGGCCACT
TGTCGCTTTA
GTGTTGGGAG
ATGCGGATrG
ATA'ITGC'FIT
GTGATGGAAG
TTTATI'GATA
ATGAATGAG
TGGTGTGGG
AAAAGACCCA
CAGATATGGA
CTTTCAAGGG
CGrGATAAAGT
GAAATCCTTG
AACCAAAGAT
TTATAGCTTG
GGATAGAATA
TTATGTGCTT
a.
a a. a a a a a. INFORM4ATION FOR SEQ ID NO:166: SS--UENCE CHARACTERISTICS: LENGTH: 1311 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .1311 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:166 a.0
ATGAACCCCC
TCAGGCAATT
GCTAAGGAAT
TFTATGCTAG
AAAAAGGGGC
ATGCTCGCAT
TI'AGCCAGGC
CTCTCTGAAT
'TAGTGGGAG
CATGAGCAAA
CTACTCTCGC
CAAAAAAAGA
AGTTTAkA.GG
GGAGGGAGTT
TCATCGTTTA
TTCTTACAAC
GTTIGCGA
AGATTCAACC
TAGTGGAATG-
TTACCCACAC
GGTTTTCAT
GTAAAACT~c
TGCTCCCCAC
TTTTACAGGG
TAGGCAAGAA
GGCAACTCTI'
TCAGCGCGTT
TCTTTFTrGAG
CTAATGTAAA
AATTGCTCAA
TGTGCTTTTA
GCCCTAAAGA
CCTTATGCGG
TCACAGGGCT
CGCCACTAAA
GTATGATTTT
CAATGACCCT
GCGCCCT?1'G
CATGGTGTAT
TAAAGAAATC
CTTTAGCGTG
TGGTAAAAA
AGCTATTTTT
TGCITGGCGT
AAATATCATG
TAATACAAAA
CCATAAAAAA
CACTTI'TACG
AAGCAGTI'
GATGCTTGCG
TATITGTAACG
AAACCCTI'AA
TACGCTTATG
ACTCTAGCGC
GGGAG'ITTGT
TCCATTATCC
GTAGGGGAAT
GGAGCAGAAT
GGTTTTATG
TCGCTCTrI'A
TAITTATTCG
GAAGAAACTA
GAAACCCATA
GCCT'AATGA
GTGTATTTrA
ATCATGCTI'
GATAAAATCA
CCTATTGTCT
AATCCCTI~jr
CGTTCCTTC
TCATCTCAGC
'FITFTGGTAA
TTATGGCGCT
GGGCGTTCTr
ATGGCGTGGT
GCTCTTrCCA
TCGTTGAAAA
CTrTAGAGGG
TGGATAATGA
TCAAAGAAAC
TAGTCI'TGG
AAATCTTrT
TAGCGCTCTC
AACGCACCCA
TT1'ATGGTAT
AGCCGCTAGT
TCCTrATTTC TITTTTAGrr
ATI'GGGGGAT
AGGCTCTTrC GTTrTrATTG
CGCCACITAT
ATATGTAACT
CGTI'ACACG
TATATI'AGCC
AGCGACTCCT
CCAAAGAGGC
GCTAACTATG
AACCAACAGC
TrATITrCATC
AAT'GCTGATG
CAAGCATGCC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020
ACTAGCGTOT
ACTTGCATTG
GTGGGTTTAG
TTAGAG'ITCA
GTTATC-TTTA
ATGAAGCCCT
CTGGGO'TTAT
CCTATGCGAT
AACAGCATGG
TGGTTATGGT
ATTTTATGAA
TAAGGCGGAA
CGCCAATGCG
TTI'TGAAGAG
TATCATATTC
ATACTCGCAT
TTATI'CCCTG
CTTI'TTGGAG
GGGTTTGTGG
CCTAAAAAAA
TGAGCAGCAT
AACATGTGCG
GGAGCGCGAG
GCTATGTCAT
CCTATTTGGA
GAGTTIIAC
AGCGCT'GGC
TTATATAGCG
GTTGAGTATT
G
1080 1140 1200 1260 1311 INFORMATION FOR SEQ ID NO:167: SEQUENCE CHARACTERISTICS: LENGTH: 285 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .285 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:167 U U
S*
U U U U. U
U.
U. *U U U
U
U U UU U
UUUU
ATGOACATTA
GAAAATACGG
AGCGTGTTTG
GCGGGGCTGC
GCGTATTTTG
GCATTTTTAG
CFI'TTAGTAT
TAGGGCATGA
AATCAAGCGG
CGGCCTTIAA
AGAATACGAT
CGGCGTGGAG
CGCAAGGGTG
CTTGAAAGTG
TGAAATAGAC
ATTAGAGGCA
TTGGGAAAAA
CATGGGCGTT
TATGATrI'AG
AATATCCAAT
TTACCCCAC
TCATGCGAGA
TTITGT'ITGA
GGCTAATCCC
GGCCC
CACTTTAGAT
ATACGATAAA
AGTTTTGAGC
CACACCGGTA
INFORMATION FOR SEQ ID NO:168: SEQUENCE CHARACTERISTICS: LENGTH: 306 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .306 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:168
U.
U
GTGTGCGACA
GCCCCCTATA
TTAGCGCAAR
GAATTTAGCA
GTTCARCTCA
TrTTITTCTGA
GFITTCACCGG
ATATCCTTCA
AAAAAGCCT'
TCCTTTGTGA
TGGCGTIT1'A
TGAAGATGTG
AGCTTGCTTG
TTTAAACCAT
AGRTGAAAGC
TTGGACAAAG
TGCGAAATCC
AATI'TAGGGG
AAAATGGATr
GTTTTAAACG
CGrI'AGTGAT
AATGCCATGG
CTAGGCTCGC
TGAGCGAGAT
CTCTAGCCAG
TTAITI'CAAA
AAGCCCCCTT
TAAAGCGGGG
TGAAGCGAGC
GCAGCI'CAA
120 180 240 300 208
GGGGGA
INFORMATION FOR SEQ ID NO:169: SEQUENCE CHARACTERISTICS: LENGTH: 381 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .381 (xi) SEQUENCE DESCRIPTION: SEQ ID N0:169
ATGTTTAAAA
GATT"IGGATT
GACTCTAGTC
ATTGTCAATA
AAGTTTAA.AA
CGCCTGGATT
TATI'ACCATA
AAATGTGTTT
TCAAGCTGGA
TTrI'AAGTAT
GGGGAAATTC
AAGAAAAACT
GCAAGCCTAA
AATTTTCCAA.
GAGCCTGCTA
TTATCGCGCG
CACTI'CTATG
AGTCGAAGCG
CTITGATCAT
CCAATGTA
ATGATAAGCG
ACTGGGGGGA
AACGATGAAC
ACTAAAAAAG
GAATTAAAAT
GAAGTTAAAA
GTGTTGTGT
AATTCATGGG
CGGTGGTGAT
TAGAACCCAA
ACTCGCAACA
TCATCACGGA
GGGGGCAAAG
GAAAATGACG
TAAAAACCT1'
ATTTGGCGAT
GATATTTTAC
CAAGGGCGAA
120 180 240 300 360 381 e *0 9* INFORMATION FOR SEQ ID NO:170: SEQUENCE CHARACTERISTICS: LENGTH: 1506 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 1506 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:170 .4 a S a
ATGACCTI'GA
TGGT"TC
CCTITAGAGT
GATAGTCATG
CTAAAAAGA
GATAATAACG
AAAGGAAGTT
AGCCATATCC
AGCTTTCGTT
TCAATAAAAG
AATCGTTCAA
TCAAACAATC
ATATACTGCA
ITGCAGA.AAT
AACCAAAGAG
ATTTAATAAA
ATCAAAAATA
TATCTCTAAA
AAAAGA TFT
ACTI'GAATIT
TTTAGAATAC
ACTGGTCTTG
ACAAACTITA
AAGTTI'GATA
AAATAC'FTGC
TTIrTCAATTC
TTTGAGAATG
AACATGCAAT
CTAGCCAATT ATCTGGGCAC ATCCTAATAA AATTTGGATT AAGATFTAGA AATCTAT?11' AAGAAATAGA TCAAGAATCA AAAAAATAGA GAGTAAGCAT ATACAAGTI'T TCTI'TGCT TAAAAATAGA 'rrC TTTAATT
ACAAAAGAAT
TTAAA.AATTC
ATAAAACTTG
AGCCAGCAAA
GTGGOATCAC
CATTTGAGCG
AATCATGTTA
GATGAAATAA
TATCCCCTAA
GGAGTGGGCC
ATCACGGATT
GACAACCCCA
ATGAAAGAAA
GATGACAGAA
GAAGAAATGC
CAAAI'GAAG
GAATTGAGCA
CAAACAAAAA
AAAAAC
TTAATAAGCT
GTGTCCGACA
AAG'ITATCA
GCACCGGCTT
ATIWAGTTT
TGCCAGCCAG
CT=GTT
GGATTGTGGA
ATAATGCAAG
AGCATGTT
ATTGTTATTT
TTCCTI'TCAC
CCATI'GAAAA
AATGCGTTTT
ATGATCCCAT
ATTGTTTCAG
TGGCTTTTAA
GAAATITIT1
TTTAGCGATC
TAACAATAAG
TTGCAGAAAA
CCAATGGGCG
TAACCATAAT
AAAGGAGT=
AGCCACCCAT
AAAGGAAACA
CAAAGACTCC
TCATAACCCC
GAGCGCTITT
T TTCTTACCC AC'TrTGCGAG.
TAACCAACAA
CACCATCCTA
CGCAAACGAT
AACAAGGCTT
AAAATTATTC
GTTCAAGATA
CTTCCTAGAG
TCCCACGATC
TTTAA'FITCA
ATTATCTATG
AGGAAAT FI
GACCCCTTTT
GAAGGCTCTG
GACGCTTTGG
CAAAAACACC
AAATTGTATT
ATTTCAGGGC
TTAGACAATC
GCAACGAGCG
CAACTCTCAG
AGAAACAAAT
'ITGTATGGCG
AAATGGATTG
GTCCCCAAGA
AGAAATATAC
ACAATGAGCC
TGTTTGGCTT
TCATGGACGA
TAAAAGAATA
TAGTGGATAC
TAATTAAGAA
ACAAAATCAA
GAATCATI=
TGCGTTACAA
TTAAAAACGA
ACCCTATrGT
AACGATTTAA
ACTGCGATAG
ACGCTAAAAA
GAGAAGATGC
CATGGGCTAC
TAGTTACCAA
GGAACATGAA
AATCATC'ITA
TCTTTATAAT
GCCAGCCACT
CGCTCATAAA
GGATCATT'A
TCACTTTAAc
ACGCTCTI'TA
TGTAGAAGc
AGAATACAAG
'ITCAAACGAT
TTTGACAGAC
AAGAGCTAAT
GCATTTCAAA
TAAGCA.AATG
GATAGAAAAA
AAACTTGATC
480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1506 INFORMATION FOR SEQ ID NO:171: SEQUENCE CHARACTERISTICS: LENGTH: 126 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .126 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:171 GTGTATTTTT FICTGGCATT GAGCGGGGAA AAAGTCT'AC TGCCCGTCAT TGGCGGTTTA GAAAAAACG CGCTAGAAGC CGGGCTGTTA AAGGGGGATA GAATCCTTCT ATCAACCATC INFORMATION FOR SEQ ID NO:172: SEQUENCE CHARACTERISTICS: LENGTH: 1050base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 1050 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:172
ATGGAAAATT
CTI'TTAGAAG
CTTCCTCCTG
AACCTAAAAA
TTTGAACATG
GACATCAATT
AAGCCACAGC
TI'GAAAGGC
AAAGAAAATG
GAAAAT'FrAC
CCTAATATTT
AACACACCGC
AAATTCTTTA
GAAATAGAAA
TTAGCTCAAA
AACGCCATCA
GAGCTTGAAA
GCGCTTTATA
TTIAAACTCAT
CTCTTTATAC
AACATGCCGT
CCIFTTTA
CTACTATCCC
TGAATAGCGA
TCCAATTTTC
AAAACCTAGG
CGATGTAT
AATTAGCAAG
TAAATGCTAA
TAGAAGAAAG
TTATGGTGAG
GCGGTITGCA
AATTACAGAT
ACACGATATC
AAGAAAGCGC
GGGGTATGGA
CAACTTTI'FI
CAACACAGGC
GAATATTAGT
TCAAGGAAAC
TCITACTATC
TGATGCTCAT
CTACAATCCA
TT1'AATCCAT
TCCTATAGAA
CAAAGAAAAA
TACAATAAGA
TCCCAAAAGG
CATTCTTATA
CCATACAAAA
TCAAATTT
CGATAATGAA
TTCTGRCTT
GGTTAGAGGC
ACCGGTCAAA
CTI'TGTGATC
GAATTCAGAA
ACCGCTAATC
CAATACCCCA
ATGACAAACC
TCCCTTTCCC
TCTAATTTAG
TTATCTAT1'G
GAATTGATTG
AAGTCTGTCT
CrTTTAAATT
GACAATCGTG
ATGCAAGAGT
OCCACCACGC
ACGGGAGTTT
ATCAGACACA
ACGATGCGGG
CTACTGCCAA
AAATCAAACT
CCATTAGTAT
CACAAACCAG
TTATAAACAC
CCATGACAAT
ATAAAATCGC
TTAATTCTCT
AAATCCTACA
ATATCCAAAT
TGTTTGGTTG
TCAAGTATCT
'FrTTAAAAGC
ACAATAAGGA
TTAAAGACAT
GCTATTCTAT
TAAAACCAAT
TCAAGTCAGT
CGATGCCGAC
CCGCACTGAA
TTACAGCAAA
AACAATAACG
GACTTATGAA
TCAAACCTAT
TAAAGCATTG
ATGTTTCAAC
CAAAGATGAA
GGGTTTTATC
TTTTATTGAT
TCTGTTTAAG,
ATTTTTATTA
AGCCTTGTTT
GCTAGAAAAA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1050 4.
4, INFOR~MATION FOR SEQ ID NO: 173: SEQUENCE CHARACTERISTICS: LENGTH: 1395 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1395 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:173
ATGGATITTA
'TGGTTITAC
AACCCGCAAC
GT~rGAAGAGT
CAAATCAATA
TTTGAAAAAC
GAGATAAAAG
ACTAAAAGAT
GAAATIGAAA
ATCCAATTGA
GTI'AAAGAAT
GGATTGGTAA
AAACTGCCI'
GAAGTI'AAAA
CAATI
4
GCTT
AAAAATGCCC
TTATTGAAAT
CGAATITATT
CAGACAAGGC
AAGCAAGCAT
GAGTCTATAA
AAAGITCTCG
ACGATCTGAT
TTCTAACCCA
CCCACCATAA
ACGACCATCT
GAGAAATAAT
F1'GAATCAAT
AACTAGAATT
CAGCAACAAA
TAA'FrrTGAA
CCACTCTAAA
TAGCATCTTA
CAATAAAATA
GA'TrCTAGA
GGATAATAGT
TGTITATGAA
TGATAGAAAT
CACAAACAGC
TGAAACGCAT
TAAAGATATrI
CCCCAGTATT
AAACAATGAA
TGAAfFTAGCT TTATTAT1'CT
AAAAAATGTG
GGACTACACA
GATAAGGGCG
CAAGAGCCAC
GATCCTATI'G
AAAGAAGATG
GCGAATAAAG
ATTGATAGAA.
TI'AAAAGAAT
AAGAAkAGCCT
TACCAAGAAG
TCTAGCGCTG
AATACCAAAC
AAAGAAGTGC
TGGATAGATA
CG'rrTC'FrG
TGCAAAAAAA
ATGTTGCAAC
TCCCTTATGT
AATGGGCAAA
TCAATITCTT
AAGGGTTIGA
ATAGAGAATT
TGAAAGAGCA.
TAGAAAATGG
TAGAAAGAAC
AGTA'TrCAA
TGAATACTAA
ATA'TI'TAAT
AAGATGATAA
TITCTCAAAT
GAAACCCAAG
AAACAATCCT
CGTGAAAACG
GTATTTAAGC
TGCCAATGGT
AAGGCGCATC
TF1'TATAAAA.
AGGG 1TAGAA
CAATGAAATC
AAAAGATGGT
GC'TrACAAC
CGACAATGAA
CCTAGAGCAA
TGCGAATTTTI
120 180 240 300 360 420 480 540 600 660 720 780 840 900 GCTTGGAAAA TGCATAGGCT AATAACGCTA ATAAGAFTAA AAAGAAGAAC AAAGCGCTAT AG TTT AGAAG AAATCGCTCA GTTAATGGTG ATGGGAATAA AACAATTTTG AAAAAGCTTA ATCATICAAG CTAAAGAGGG CCTAT1'AAAA ATACAATAGA ATAATCATCC AAATT
TATCAATGAA
GCAATTTTrC
ACA.AGAAAAC
AGCAAAAATT
AAGAGAAATC
TAAGGAGCGT
TGGTAATGAG
GACTAATACT
AATAAACTCA
TTTAATAATG
AGAGATTATT
GAATTGCAAA
AAGCCTTIWA
TATGACAAAT
CGACAAAATT
TCTAACAATA
AAGAAAAccA
GTTCTATTTT
cTTTAAGAAG
AATACTATGA
AAGAAATTTT
TGGTAAGcTT CTAGTcA ITATTcAAAA
TCTCAGCGCC
AGGCTGGACT
CGCTCTTI'A
AAGCGITTAT
AAGAGACACC
GAGTGCAGCA
TAACAATAAC
TAATGATAAT
960 1020 1080 1140 1200 1260 1320 1380 1395 INFORMATION FOR SEQ ID NO:174: SEQUENCE CHARACTERISTICS: LENGTH: 579 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 579 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:174 a. a a a.
ATGGCGCTTG
AAATATGAAG
AAACAATTTG
TXFFI'TTATA
CTAGAGTTTG
GTGATGGCGT
TI'GCATAGCG
GTI'GAAGGGA
TATGACCCAA
CTAATA.AAGT
AAGTGGTIT
GGTTTAAGGC
AAG?1'TATCA
ACGAGATTT'
GCGCTATCAT
TTATTGATAA
AAI'IGCAAGT
GTCCGCCTGA
GCCGTATGCT
GGCGTITTTG
ATGGGATTTT
GTTGITTCAA
CTATCAAAGT
AAAAACCCCT
AGAGCAAAAG
GCATTATCAA
GTI'GTGCGAG
TAAACCCAAG
AATGATAGCG
GGCTATAACA
GATGGCGTGA TTTITGACAG
AAGCATGGCA
GGGGGGATTT
ATCGCTCAAG
CT"ITrGATA
AATTATATTT
T1WTTAGGGA
ATTATCGCTA
ATAGCGTCAA
GCAAGGTT
ACGATAGTAA
CAAGGAATGA
AAGAAATAGA
GGGGGCATTT
'ICCATATCGC
TTACTAAGTA
ATATCAT1'CA
TGA'ITATGAA
CATGCATTTA
AGAGGGTTTG
AAAGATCCAA
TGCA'ITAGCC
GAATAGCGAR
TTCAGCGGCC
TTTTAAGAGC
AAAATACGCC
AGCGCTAAGG
120 180 240 300 360 420 480 540 579 INFORMATION FOR SEQ ID NO:175: SEQUENCE CHARACTERISTICS: LENGTH: 423 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1. 423 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:175
ATGCTCAAAA
TTCATCCCTT
ITTGTGGGCA
TTTCCAGGAC
TATITTT AG
TTTGTCGCTC
GCGCAGTTTT
AAAAGATTGA
TAGTIrT'FTC
AAAAACTGGG
TCATTGCGTA
GTCAAAATAA
TAAGCGCCTT
TI'GGGAGCAA
TFI'GCATAAA
TATGATCTCA
TAAAGAAGCT
TGAATI'GCTr
AACCCATAGG
TATTrGAGC
TGACGCTTTA
GATTCTATTA
CTTTCTACTT
ATCGCTGCGG
TTT-GGTTTTG
GCTAGGCTTG
ATGGCGTTAT
TTGAACATGT
GGAAGCTCTT
ACTCTATGGT
TCAATATCGC
GGGCAGCGAG
TGTTTAGCAG
TGCCTTTTAG
CAAACGCTAT
TT'TrAF'Ac
AGATGACATG
ATGGCCTATr
CATTGTGGGG
CGTGTTTTAT
CGAAAATATC
ATTGAAATCA
120 180 240 300 360 420 423 INFORMATION FOR SEQ ID NO:176: SEQUENCE CHARACTERISTICS: LENGTH: 477 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .477 (xi) SEQUENCE DESCRIPTION: SEQ, ID NO: 176 *4 4
GTGAAATGTT
AAAACGACTA
ITAGTCCAGC
ATACTAGGGG
GTTGGCATGG
TI'AGACTACG
AGCGTGAATG
GTRCTGGTTA
TATTAATAA
CCC CTATTT
ATTATITACT
GI'TTGTCGGG
AGAGCGCGAA
CTAAATTACA
AAGCCAATAT
CARCGAGCCA
AAAATCACTT
AGCGCCTATG
GGCTTTAGAG
TGCSCAAAGG
AGTCITAARC
AAACCACCCT
CATTCAAGCC
AACCCCTAAA
CTATTI'GCAC
AGCGTGGTGG
CATGTTAAAG
GCTAAAATCG
CAAATGGGGR
TATTATCATI'
TTAAACGGGR
GTGRTC?1'A?
TGAAACCATT
CTGGGAGGTI'
GGTTTATGCG
TCGTAATTGG
CTAAAGTAAC
TGTATGATT
CGGTGGGGCT
GAAGGCATTT
GCCGGACCTA
GRCTSCSCAT
TAAGGGGGTC
AGGCGGTGTG
GATITTAGAA
AGAAGTC'ITA
AGTGGGAGCG
AAAATAC
120 180 240 300 360 420 477 S S
S
INFORMATION FOR SEQ ID NO:177: SEQUENCE CHARACTERISTICS: LENGTH: 1128 base pairs TYPE: nucleic acid STRANDEDNESS-: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (iX) FEATURE: NAME/KEY: misc_feature LOCATION .1128 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:177
ATGCTTGCAA
GAGCAGTITG
GAAGACGCTC
TTGGTFFI'TA
GATI'TAGAAA
ATCCTTACTG
CTI'TATAAGA
CAAGAAGATA
AAAAAAACTA
TCTT TAGATG
ATTGAAGAAT
GATTATTACT
AAAGCCACCA
AAGATCAATG
AAAGATGATG
GCACAAAAAC
AAAAAATCTA
ATGAGCGACA
GTGGTTTCTG
AAATCGTTT1
GTTCAT'TTT
TTAAAGCTCG
GAAAACAAAA
ACAAGTACAA
CTAAGTCAAA
AACTTCTI'CC
AGGAGCG=T
CCGCTACCAC
AAGAGCAAAA
ATTCCAATAA
TGCAGCTTGA
ACACGCTTAT
AGAAATACTT
TGGAGTTGAA
AAAAATTGTG
TATTAAAAAA
AAACAACTAT
CATACCGGAA
TAGCTCATTG
CAACGAGATA
CAAGAAGCTC
AATCAAAGAG
AAAAGAAAAA
GGCTTATGGT
TAACCCTTAT
GAGTTATTAC
TAAAGATAAG
CAAAAAAGCG
CATTTCTAAT
AAGAAACAAA
TTFAACTCG
AAGGGGCTAT
TACTTTGACT
TTTGTTGGTT
GACTAATGAA
GCAAAAAGAA
CAATGTTGCC
GTTGCGTT TG
AAAAAAGAAC
TTAAACAATA
CTTGTGGATT
GAGGCTCTAG
GATCTAGAGC
GCTTATGII
TACCCCCAAG
GCTCAGGCTT
AGCCGATTAG
TTATTGAGCA
TTTGACTCCA
GAACGCTTGG
GAAGCTTTTT
AAAAACTTCA
TTAGACAGCT
TACAATATCT
CACTACAAGA
AAGAATAACC
GAGTTTTGTC
AAGAAGAAGT
CGCATGATTT
ACAGAGCTAA
AGAAAGAGAC
AAGCCTTAAA
TAAACCAAGA
TGAAAACGAG
TGCTTCAAAT
CT ATCTTA
GAAAAGAATT
AAGCAAAAGA
CGTTTAGCAT
CTAACTTGTT
CCAATCAAAA
TCAATTTGA
TCGTAGATAG
TATTTAATI
CCT'TTGAA.
GOCTAATGTG
GGCCGCAAAA
CTTAGAAGAC
AGTTCTrTTA
AAGAGGTAAA
AGATAACCCT
AACATTCACG
CAGTATTT
GGGTGTGTTT
CAAGCAAGCG
GGATAATATA
TATTGCTCAA
GGCGATTGAT
GAAAAATGTC
ATTGAGTTC
TACCCAATCC
CGATCCTATG
CTTCAAAACA
120 180 240 300 360 420 480 540 600 660 *72 0 780 840 900 960 1020 1080 1128 INFORMATION FOR SEQ ID NO:178: SEQUENCE CHARACTERISTICS: LENGTH: 1056 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1056 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:178 6
ATGGATTCG
F1'GTGATCC
CTCAAGCATG
TATACCACCC
CATTTAGCCA
TTIAAAAACG
AAGACCAAAA
FIAAAAACCG
CTCCCTAACG
TCCATCATCG
CATAGCGGAG
TTGCATGAAA
ACAGAAGAAC
GTGGA'1TAG
=TCATGTGA
GCCTCTATIG
TAGGGTTTGA
GTAACGATAA
C ITTTI'AGA CAATTGCTTr
CCACCCYCAA
CCAAACTCGC
TCTA'ITCTTG
AATACGAATA
CTCAACFI'AA
CTTCAAAACT
GCAGTTCGCC
AATTAAGTTG
TCCTTAAAGA
CCAAATTGTG
ACGCTFIATT
CCAGATGGCG
AGA'TTAAAA
GTTAGGCGAT
AAAAGGCGTA
AGAMTTCCCT
AAACCGCTCC
1T1CAGTTTG GCTT TATCAA
CAFITGGAC
AAAAATCGCA
CAACGCTAAT
CGTATTGCCC
TGAGATCT
AGTCCCTI'C
CGCGAA TA
TGACAACCAA
GCCTTCAAC
TGCAAAGACA
TTTATITIAG
GAAGTGTATI
TTCATTGATG
ATTGACGCTC
AGAAAATCCA
AAGAGAGTGC
TTAATCCATG
TGGA.AGCTTA
GTTGATCTAT
GCTTCGCATT
CTTATT1'GCG
GCTCACCTCT
AGCGTCTGTA
TCTATCGGGT
GAACAAFT
AAGAAAACTC
YGAITCCCGC
TGGGCGTGGT
AAGTI'ATCAT
TTATCTF=
TCCCTI'ATAT
GCCAAAACCG
CGTrTGTA.A
AAGACAAATC
TGTGGATTGG
TCATI'GAGTT
GGCCAGGCGA
ATGATACGAG
TCGGGAACGC
FFACCCTAA
TAGGCATCAC
TCAAAAAGI'
TTAATCGCT
TGTGCCTAGC
AGAAGACAAC
ATI'TCTAAT
CCTAGCCCCA
CTCTTTATGC
AGACTACGAT
CAAAGAGCGA
CGTGCATATG
GATTGCAATC
GAGAAAAGCC
CCATAGTT'TA
TICAGGCCCT
CGAACTCACC
CCCGCCTAAT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 GGCTCAAACG ATATGGGTI'T GAFI'GACATT CAAAAAGAAA GCGAAAAGAT TATGGGATT ATCACAAAAA ATCTTCTCA TCACATGCAA GAAAGA INFORMATION FOR SEQ ID NO:179: SEQUENCE CHARACTERISTICS: LENGTH: 264 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .264 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:179 1020 1056 a. a *aa.
a a. at S. a.
S
GT3GGTG TCT
GGGGTGTTGT
T'IIAGGGAGC
GAAGTCTTCC
TTAGTCTTTT
TATCCCTCAA
TAGCATGT
AATACCAATG
CTATTCATCA
CCCCTATI'GG
AATAGAGGCA A TTTCTAATT TTATCTITTTA GACGCTTATT GCTAATAAAA AACCGACFI'A AACTTGCCAA TCAACGCAAT
GCGT
'ITTATGGGTT
ATCTCATGCA
AAACCGATGA
TCTTATCGCC
ATGCGTTTTA
AGAAAGGCTG
AAGGCTGTFI'
ATGCGTTCGT
120 180 240 264 INFORMATION FOR SEQ ID NO:180: SEQUENCE CHARACTERISTICS: LENGTH: 315 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: -misc-feature LOCATION .315 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:180
ATGTCTITAG
GATCTGAGAG
AAAGGCAAAA
TGGACAAITA
CCGCCCACGA.
TTTAGTGATT
GGGCAGTGGT
CGTATCGTTS
AACGCCTTCT
GAAATCGCAC
ATAACCACAC
GGTAT
CAGCTCACTC
RARAGCTTAT
TITACAATTAT
GTRATCATTG
CATTCAATGG
CTTTGCCATA
TATCACGAAA
ATI'AAAGCCC
GGAAAATTTA
AAAAACRGAA
AG'rrAGAGGG
ATAAAGATAC
ATATTGYT
CTCAAAATCC
AACA'FrCTAA
GGCAATATIA
YTTGCTTATT
AAkAC LTGCTA
AACCGAACAA
TGGACAGAAT
215 INFORMATION FOR SEQ ID NO:18l: SEQUENCE CHARACTERISTICS: LENGTH: 228 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .228 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:l81 S. ATG.AAAAAAA CAACCCTCTI' TGTA.TTGGGC TTATTATTCA GATGGGATTT CTCAAACCGA GCCTTCTTCT TTGAA=TGG AACCATTCTA ACGCCCAAAA ACTCTCT'rA. AAAAACGCAT CATGAAGGCT TGCATGCGCA GAATACGCCA TTAAGCGAGC INFORMATION FOR SEQ ID NO:182: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 294 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular ATAGCTCT'T AAGCGCTGFr CTGAAGATAG CCTGCCTTTG GGAATAGGGT GTTGTCTAAT
GAGTAAAA
(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni Cix) FEATURE: NAME/KEY: misc-feature LOCATION .294 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:182 *5
S
GTGAAAAAAG
GTGATCGTGC
CAAGTGGATA
GCTA'ITTCTA
AAACACAAGG
TAGAATCCAT
TCACAACGGC
AGGATACCAC
ATAAGGGTTC
TICCACTT
GAATGTGGTG
GTCTTTTGTG
TGA'ITCTAAA
?I'TITATT
GGCTAAAGAC
CCTrTCArrG
CAAACTTCAA
GATGTGTTGG
GACGATAAAG
ACCCCTATTG
ACATCATGCT
AGCTI'CCTAT
ACAAAAAACA
AAATCAGCTT
TCTITGCAAG
TGTGTTGTTA
TAGCATTCCT
AGTI'ACGATC
TGAAAATTTA
GCGA
INFORMATION FOR SEQ ID NO:183: SEQUENCE CHARACTERISTICS: LENGTH: 486 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .486 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:183
ATGGGATCTT
ACGATAGATT
GTGGTGGGGA
GAAGAAGCTG
AGTGAGGGGT
ATGCTCATTG
AAGAA_2ACAAA GT ITTTGTT
ACCT
ACACATTCCC
TTTATGCGAA
GCATCAACGC
AATTAGGGAC
ATTIGAATTA
CAAGCAGCAT
TCGCTTTAAG
TATGGTATTT
TCTCATTTTG
CGCCAATTAC
CTTAAACGAT
AGACGGGATT
CGCGCTCTCT
GITTACTAGC
GCTGTGCGCA
TGGGGCGCTG
AAGCCAATAT
TTTTTGATT
GAAATCAGGT
AAGATTAAGC
AGCGTGI'TA
TCCAGGCGTT
AGACTC'ITGG
TTTTTT1
TTATAAACAA
ATGGTGCGT
TCAAACGCAA
CTATCGCTTT
TTITCATCTT
TGGAATTGGC
TGTTCATGGG
ATGGGATCGA
AGTGCCTGTA
AGCGAATGCG
CGCCCAAATA
GTATAACCCT
ACACCAGGTG
CCTTTTAGAC
GGCGTTTAGC
ACGGCATGGA
120 180 240 300 360 420 480 486
U.
0*e* INFORMATION FOR SEQ ID NO:184: SEQUENCE CHARACTERISTICS: LENGTH: 174 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .174 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:184 GTGATTATGA CTAAGCTI'GA TGGCACTTCT AAGGGCGGAG CGA TrTARG CGTGCTGTAT GAGTTGAAAT TACCCATTCT TTATITAGGA ATGGGCGAAA AAGAAGACGA TTTGATCGCT TTATGAAG AACGCTTTAT AGAAGATTTG GTTGATGCGG TGFTGTGGA ACAA INFORMATION FOR SEQ ID NO:185: SEQUENCE CHARACTERISTICS: LENGTH: 198 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular
U.
(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...198 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:185 GTGTGTGGGG CTCATGGAAA GAGCAGTATC ACGGYCATGT TTTGGASSGA TTATTGGGCG GCATTCTAAA GAGTTTGATT GATATGAGTT TGGTTTTTGA ASCCGATGAA AGTGATTCAA TTTTTGCGCG ATTGTGCC TGAGCGCGAT TTGCCCCGCT CCAATGTSSG AGAGAGCGCG GTTTTTTTAT TTTCCAACCC INFORMATION FOR SEQ ID NO:186: SEQUENCE CHARACTERISTICS: LENGTH: 231 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...231 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:186 GTGAATGAGT TAAAAAACTC TAAGCAAGTT TTAGGGAATG GGAAAGCCGA GAAAACACCA AGGTAAGGCA GACTAAAACA RATCTGACTG AAAAAAATCA ACAGAAAAAA CAGAATTAAA TAACAAGATT ACTGGGTTAG CCACAGAAAA GCCGCAGACA AAGAAAACCT AACTAAAGAA AGCAGACAAA GAAAACCTAA ft
TCTGAGCAAC
AAGGCTAACC
AGAAAGGTTA
C
120 180 231 00d, INFORMATION FOR SEQ ID NO:187: SEQUENCE CHARACTERISTICS: LENGTH: 555 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori
I
(ix) FEATURE: NAME/KEY: misc_feature LOCATION 1. 555 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:187
ATGGATITAC
CAAGATACCC
GGGCGTAAAA
CCTTGTGTGA
CGAAGCACTT
GAGCAA.AAGC
ACAATGAACT
'TITAAGGATA
GCTAATATCT
AACAAATTGA
CCCTAAAACA
AAAGCTTGTT
TAAAAGAACT
TTATTGAAGA
TITI'AAAGCA
TGAATGAATT
CACTAGAACA
TAGCCAATAT
TGAGCTAGAA
AGAGCCTAGC
AGATGAAGAT
TkAATGAATTT AGCGCT1'ATT
ACTAGAAAGA
TTTTACGCAT
AGAAATCAGC
GGTGTI'TGCT
AATAAGTTG
ACAAAGGAAG
AAGAAAAAGA
TTGCTAGAAT
AGGCAITTAA
TTACAAAACA
AAGATAATCT
CAAGCTAGTT
AAGATAAGCA
AAGAACAAGA
TAAAAATCCC
GCTTTAACAT
TTGGCTCATT
AACACAGAAA
AAGAAAAGGG
ATAAAGACAC
TAGTAGAGAA
ATGAGAATGC
AGAACAAGCC
TAAAAAAAGG
TGCCTTTAGT
TAAAGAGACA
AAACACCCAA
AATAATGA.AA
CCCTTTAAAG
GTTAATCT'A
CCCTAAAAT'
120 180 240 300 360 420 480 540 555 CTTATI'TCA CGGCT 9 99 9 9 9099 99 *990 99 99 9 4 4 99 9 99.9 90 09 9 4999 9999 9 99 9* 9 999 9 INFORMATION FOR SEQ ID NO:188: SEQUENCE CHARACTERISTICS.
LENGTH: 432 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .432 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:188 ATGGGGTGCT ATGGGATAGG GATGATCTAG RCTGTGTGTG TCTAACCTGA AAGATGAAGC CAAAAGGGCG 'FrGATGCGCT GATITI'GAAT TGATIGGGGA AAGGAA TTT G AATGCATCAA ATTAGAAGAA AAAAT TT1'AG AGTGATTGGC TC
CATTAGCCGG
GACGAAAAAT
GCAAAAAAAA
GTTAGATGAC
ACGATIAGCC
ACGCGCTAAT
AAATGT'AGC
TTGCTCAGCG
ACCGCTCCTT
CTCGCTTTTG
AGAGACGCTC
TTGATTGTTG
TTAGAAAAGC
GAGCGA.ATAA
TGATI'TTAGA
TTGATGTGGT
AAGTGTATGA
GTTTTGGGGC
GGAAGCAAAC
AAACGATCAA
GGGGAGGGAA
GCAA.AAAAGC
GATCGTGGTT
AAGACTGCTC
GAAGATGAGG
TTTAGAGAGT
AGACATAGGA
TGGAAAAAYT
INFORMATION FOR SEQ ID NO:189: SEQUENCE CHARACTERISTICS: LENGTH: 270 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .270 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:189
ATGGAAATAC
GGAGCGTTGA
ATTCCAGCCA
CTTAGTTGGG
GTTTGGCGCA.
AACAAACACA
TTAGCGCCAT
TTGTTGGGGG
GACTCAAACA
TI'CAAGCAGG
CCGCAAAATC AATCGCCCTI' ACCGCAAGAG AGTCATGCCG TATCGCCACA GGCACTGCTG AGCCGAAGAA GCGAATAAAA
AAAAGGGCTI'
TAGTTTCTCT
CCTTTITCAC
TAGGAACGGT
CCCCAGATAA
CGTTAGCA
GACCGTGATC
CTCAGGGCTT
ACCCGATAAA
*e*0 9* INFORMATION FOR SEQ ID NO:190: SEQUENCE CHARACTERISTICS: LENGTH: 804 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .804 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:190 **0 0* a
ATGTCAGAAA
ACTAAAA.AGG
GTGTTTTGGA
ATGCAAAAAA
ATGGA'FICTC
GAGAGTGAAA
GAAGAAAAAC
CAAAAAGAAT
CCAAAAGATA
AAAAAAGAAG
GGGCATTA'Fr
TITAATCAAT
CCTTATAAGA
AAACCGGTI'G
AAGAAAGACT GAATGAAGTG TG'TTTGAT CGTGGCCATA AAAGCACCAG AGTCGCTCCT TAGGCAACAC TAAAGATGAG CCAA.ACAAGA AGACAAGTTA ATI'CTATGCC CATTCAAACC AAGAATCTCA AAAAGAATI'A CTCAGGCTGT GGCTAAAAAA AAGAAGCGCA TAAAGRTAAA CTCGTAAAGA AG TTT CTAAG TGC.GTGGG GGFTTT=GCG TCCCCCATAA AAF1'GAAGAT GCAAGCAAGA AGCCTAATG TCATAGAAGT GCGG
ATCTTAGAAG
GCCATTATCA
AAAGAGACTT
AAAAAAGACG
GACAAAGTGG
GATCAAGCTC
AAAGCTGTTG
GAAACCCCCC
GCTAAGCATG
AAAGCTAATT
CACACGCCCA
AGGGGGGCTA
CATGCCGA'rG
AAGAGAATAA
T'ITTGGCGGT
TTTTACAAAC
ATGAGTTI'GA
TGGATAATAT
AAATGGAGAT
AGCCTATTCC
ATAAAAAGCC
CAGCTAARGA
CTAAAACCAA
ACAAAGCCTT
CTAAACGCTA
AAGTCAGCAA
TGGGAGTGGT
GC-TTTTIAATG
CGATAGTGGC
AAGCTTGAAT
TAAAAAACAA
GAAAACAACA
CATGAGCACT
TAAAGTAGCG
GCCAAAAGTC
TCTTACTAAA
TTTACAAGAG
CCTYATAGGY
GAAGATGACT
120 180 240 300 360 420 480 540 600 660 720 780 804 INFORMATION FOR SEQ ID NO:191: SEQUENCE CHARACTERISTICS: LENGTH: 513 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (gerlomic) (iii) HYPOTHETICAL: NO ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .513 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:191
GTGGAATATT
CATTTGAATC
GAGCGCTTGG
AGGCAGATGG
GAGCCTACGA
GAGATGAAAA
AGGCACTCCA
CCAATCGCTA
TGGCATGATG
ATGCGTTTAA
TGTTCGCTAT
ATITAGAGTC
TACTTTTAGC
GTGCG'ITAGA
AACGAGAATI'
CGCATGTGGT
TGACTTCACA
ATAAGCTTGT
TTTCAGCGTG
GCCTAAAGCT
CTTAAAAGAT
CAGAAGCTTG
TTTAAAAAAC
GAGCGITTI'A
CATGCTCAAA
CAATTTAAGC
GGTGTATGCG
TTGGAITI'TG
AAGCACATTA
CAAGGCATTA
TGCAAAGAA
CAAGCCCTTT
GTCAATATCC
GATAAAAAAC
GCGCTTTATG
TTG
TCTI'AATGGG
AAGAAGCCAC
ACGATTTGTC
CGCCCTTATT
T'IT=GATGC
ATGATCCCAA
TTTITTGCA
ACACGCCCCT
GAAAGCGACG
GAGCGTTI'A
CGGCGGTCAA
GTTACTGGAT
GATTAAAGAT
TTI'GGTTGCC
AGCTTCCACG
ARAAGCGATC
9* INFORMATION FOR SEQ ID NO:192: SEQUENCE CHARACTERISTICS: LENGTH: 306 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1 .306 (xi) SEQUENCE DESCRIPT:z:::: SEQ ID NO:192
ATGATGGCAC
GTGGITCAAC
AATTCAGGAT
GACAAAG CC C
TACAATATCA
GATAAA
ATTCACTTAT
CTGATGGGAA
TGAGATGGTA
ITGTAACAGT
AAAACTATGG
GA7ZAA.,~ TGAATh
AAAACATCAC
ACTGATGCCG
GAAATTGCAG
GGCTATGGGA
CGTGTGATTA
TCTCCAACCT
CCATTGATCC
AGAAGTTTAA
AAAATCCATT
AAAAGCTC CC GC'rrA'FrTI
TAACATGACT
GCTCATTAAA
GACAAAAAAT
TCTITGTCAGA
120 180 240 300 306 INFORMATION FOR SEQ ID NO:193: SEQUENCE CHARACTERISTICS: LENGTH: 711 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAMEIKEY: misc_feature LOCATION 7)11 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:193
GTGCTGAATG
GAAACCCCCC
ACGATI'AGTA
AAGCTTTATA
TTGTFIACTAG
ACCAATAACG
TI'AGACTTGC
GATGCGATGA
CATTTGTTTG
ATTAAATTCA
TCTAAAGAAA
GATCCGGATT
AAGAGCAAAA
TAAAGGGCAT
AAATCAAAAG
TCGCGCTTGG
GGCATAAAAA
AAACGCCTAA
CTGATITAAT
TGCAAAAAGC
ATAAGATCGC
AAGAAAAGGA
ACGCGAGCGT
TOTATTATCA
TCATAGAA
TCATTCTAAA
CTCTAAAGAG
AATATTGCTT
AGAAAATAAA
CGACACCAAT
CGGCAAAGAC
GAGCCTTTTG
TTCTITTCTCG
TT'ITAATGGG
GRGCGCGA T
TTATCTAAAA
GAAAAAGGGG
ATCCCCTCTT
TTTTTCAAAC
TCACTCATCG
CAAACTTCTT
AACGCAGAAG
TCTTTGAAA.A
TATGAGCAAG
CAAGGGATTG
GCGTTGGATT
GATGCGTTAG
ATTGTRAAGA
GCGAAAACAA
TGAAGCAGGC-
AGCTTCTACA
CGCTCATTGT
TACAAACTAA
CCGAAGGGCA
GAAACGATGA
GGCAAAAAGA
CGAGCCATAA
TGTTI'GATTC
TTACGG-CT'A
GACACTTGT
AAACGAAAAA
TTTGGAGCAG
CAATAAAAAA
GGCT TTGAGT
TACCGCCACC
AATAGAAAAT
AAGCCAAGTG
TGAAGCCTTG
TCTAGGGGTG
CAGTATCGCT
TCATTTGCAA
A
o. to* too INFORMATION FOR SEQ ID NO:194: SEQUENCE CHARACTERISTICS: LENGTH: 675 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .675 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:194
ATGAATACAA
CGCCTTTTGT
ATTAACGCCC
GCTCTIACAA
CATGAGCTCA
AGCAATATCA
AATAGCGGGG
TI'AACGCTCC
GCGGCGTTI'
GATIACACCA
C'FI'TAACG
AGAAAGCGTG
GCTTATI'GAC
TAGAGCT1i
CFI'ACATGAA
GCGCITTTAAT
GCCACATACG
TGCTATTGGT
CGAATTTAGC
,TrIrIGCAAAT
TAATGCATGA
ACAACGATI'A
CTGAAATGTT
TGATC
CCAAGCACAG
AGAAGAGGCT
CGCTTITGCG
AGAGAGGTTA
GCACAACGAC
GGCTAkTT
CCGAATGATT
GTATTTGAGC
CAATAAGCCC
TAAAGAAATA
TAGCACCCAC
GTITTAAGCT
AAGCITCATT
AGCGGGTGGG
GATAGAGACG
ATCCGC 1TGA
AGCGTGTATT
TTIATGGGTTT
CGCACACGAG
ATGATCAGAG
GATAAAAATA
CTAAAGAAAA
TTGAGCCTAA
ATGAATCTAA
AATTAAAAGC
CCATGTGCGT
TIITCATGGG
TACAGATCAT
AATACATGGC
CCTI'ACAAAA
GCACCCGATC
TCAAATCCAT
GCITTATATC
TTCCCTTATC
CGTGATCGCT
GGGGATTITG
GAATCGCAAG
CTTGCCTITTT
CGATAGCGGG
GATTTCTAAC
AGCGGCCTAT
CCAATCCTTA
120 180 240 300 360 420 480 540 600 660 675 CCTAGTXITA AAAATCGTAT INFORMATION FOR SEQ ID NO:195: SEQUENCE CHARACTERISTICS: LENGTH: 1605 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .160S (xi) SEQUENCE DESCRIPTION: SEQ ID NO:195
S.
S V *5S@
S
S.
5* OS S S J S S S S. S *55 S S 55 5
ATGTTTAATA
AATrGGTI'GA
TATTGCATGC
GGCTATACAT
GCGCTTAGCA
ACTTTAGGTC
GCTCTAACGC
GATGTATCCA
GGCGGTGTI'G
GCTCAAGCTI
ACTGCAAATA
GTI'GTCAAAG
ATTATCATAG
GGGATTTTTG
AACATAGGT
TCTTTTATCG
GGTITAGCAG
AATTACACTG
AACGCTCCTA
ATGCAAGTAA.
GCTrAGCG
GAI'CTATGA
ATTCCTATFI'
TCTGTTGCTA
="GATCACTC
ATCGT1'AACA
GATGCCTTAA
TTAAAAGGAC
AAGCTATTGA
TGATACCGAG
CTATTGGTGC
CACC.ATTAGC
CTTTATGGGG
CATCAAGTGG
TGGATAGCGT
AGGACAATGT
CTACGAATAT
AACTGCAAAA
GAGCGGACGC
GGCAAGGGTC
TI TTTATTTC
TTGAATACAT
CCTATGCAGG
GTGCTTTI'GG
TTAATTCAAT
GFFI'GTTACA.
CTATCATTAT
GTATTGTT
AAAACATATI
TGCTCTTTGG
TACAAAACAT
TATTTATTTT
CCATrTCAG
TGGTGGGAAG
TTITTTTAATA
TITGCCCATT
TTATGTT1'TA
ATCAGGGAGT
CACAAGTTTA
ATCGGCGTGG
CTGTAATTT
ACTAGACAAT
GAAAGGCAAT
TACAGCTGAT
CAACACTATA
TGCTGTTCTT
ATATCTTGAT
TTTTATGAAA
GCGXTTTGTT
TITTGGTTAT
GCTGAATCAA
TTI'ACCTGCG
AGGCTI'GCAA.
GAGAATAAGC
CCCTATTGCA
GATATGGTT
TGTTTI'GGCA
CAATCAAGG
AAAAGG TrC
CTCTGTCTCT
AGTTGGTGGA
ACGATCATAA GTITTTTTCT GITI'CAAATC TCAAAATTIA ACCAACAAAA GTFTTGCAGA GGAAAGAGTT CAGGGCAGGG GCCGCTAGCA ATCTGGTGAA GCAAGTGTTG CTACAGCTAT GGTTGGAACG CA'FrGATAAA TTGAGCAACA AGATTCAGAA ATTCTTTTAC AAATAATTGG GGTI'TAATTIT GGCTGATTGG GCCATGCTTG CTI'TGCCGC CCTGCATATG GTGTAGTCAA TTI'GTTTCT ACCTAATT'A TTGAGAGATA ITTCAAACGG GGGGGGACAT TATICAAAAT CTITATAAAA TCTCTTA'FrC G'ITCIITTTlat GGGCTTTAGA GTAAGAGCTG T"IITCTAA GTGGCAGGTA TrI'CTTTATT ACTGTrGTTG TGAAACCTT GTATG'IITGA TCGTGCTAGA.
ATIAATAATC TG'rrTATCTT TATTGGCAT TCAATTI'GAC GGATTGGGTA TCGATTCAAC ATAGAGACCA TTATrGAGAG ATGGATGGTA GCAGAATGGA TCTATGTTTA AAGGA
CATTGTTCCT
CCAAACAGTT
TATTTTGACA
TGTGATCGAA
ATATTTGAAT
ACAAGGTTTT
TAAAAACATA
TTTTACCAAA
CTCAATAACC
TAAAGAATTC
ATTAGAATCT
TCTGCCTGAT
TAF1'GTTFI'T
CATTCAGATT
GGCGATGGTC
TATTTATT
TTTAGTGCTG
TGTTGGCAAC
CGCTA ITFI'
GATAGCGGGG
TITGGITCA-AA
GGTTICTAGCT
CATAACGCCC
TATTGCGAGT
CGTCAATGCG
TAGAGAkAGA 120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1605
S
INFORMATION FOR SEQID NO:196: SEQUENCE CHARACTERISTICS: LENGTH: 426 base pairs TYPE: nucleic acid STRANDEDNESS: double D) TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .426 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:196
ATGGCGTTT
ACCArTGATGT
GAAGCGAGTC
GTCCCTGAAG
AAITCTATGG
ATGTTTGGTT
GAGFI'TGACC
AAAGGC
GGCAGGCTAT
GGATTCTI'TC
GTGCGGCTAA
AATACATGGG
ACGATAGATT
ATITCTACGGA
ACTATGGCGA
CCGGTGGTGG
AGAAATGGCG
CCCGGTTTTA
CGATGTGATT
AGGITTTGAAA
TTI'GCGATCA
AGTGCCTAGC
ATITTAAAGT
TTTAAAATCG
CTAGAGCCTA
GGCGATTI'AA
ATCGTGAATG
GCCACTCAAG
AATATCGCTA
TACCCTTTAT
CTGGYTYTAT
TGATGAAAGT
ACAGAAGAAG
CTTTCGTGCC
GGCGTGGGAC
AGCAAATCGT
GATGGGAGCT
GGCGITTAAA
GGAAGTGGAA
AGGGCAAATC
GTI'AGTGGMA
TTACTCTATG
GGAAAAACGC
120 180 240 300 360 420 426 55.* S S *0
*SSS
INFORMATION FOR SEQ I0 NO:197: SEQUENCE CHARACTERISTICS: LENGTH: 459 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAMEfKEY: misc-feature LOCATION .459 (xi) SEQUENCE DESCRIPTI=:: SEQ ID NO: 197
S.
S S
ATGCAGAATT
CCTGAGGGTG
GTAGGCTATG
GCGTTAAAAA
AGATTGGGCT
CAAGGGATCT
TATATCCCTA
TITTGGTGGCA
TGCCGGGTAT
AAGGGGCT
TGAACGCCCA
ATGTGNITGGC
TGCTTGGGTG
TACCTCCTAC
ATACAGCCAG
CTAATGGTGT
GGC;A:;ASCG
AGA::A...
NJ
GCGATGCTAA
AAAATGGCTT
ACGCA?1'ATA
ALAGTCCCTCC
AGAAGCCGTT
GAAACGCCTG
GTGAATGCGG
AAAAAAGCC
CCACATCATC
CAGAA.ATGGC
ACGATTGGTA
TGNITAGCTCC
ATI'CTATCAT
ACCCAGAATG
TGATGAGTAA
AGCCCCAGCC
GAAAGTGGAA
TGAAAGCATT
ACTAAAGGGC
GGCCATGAAY
CGAYCTGGAT
CTCATI'TGGT
INFORMATION FOR SEQ :D SEQUENCE CHARACTER'ISTICS: LENGTH: 279 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .279 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:l98
ATGATACTAA
GCTAAT'ITTT
TI'AGCTTTAA
GGTI'GGCTAG
TI'AAGCTATG
AAAATTTGAT
ATACCATTAG
AATTTGAAGC
ACGCTAAAAG
TGAATGATIT
TTTG'ITATT
TGGGAGCAAG.
ATITCCTAAT
CAAGCTCCAA
TATATCAAAG
TTAGCAAAGA
CTTAATGAAG
TACGAATTTA
GAAGCTTACA
GTGCAAAAA
GAAAACTTAT TTTCATAGAA TCGCAAGATC CTATCAAGAC TTI'GGATAAC TGATGGCATA AATCTGTAGA AATCTATAAC INFORMATION FOR SEQ ID NO:l99: SEQUENCE CHARACTERISTICS: LENGTH: 264 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .264 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:19!
ATGGAATCAC
T1ACCGGTAT
ACCCAAATCA
CTGATTI'AA
AAGCTCATTC
AACTCATGAA
TATTAGCGGG
ATGAAATGAC
CCATGCCGTG
CTAAAATCAT
ACTCGCCATT GAAACTTATA CTTAGTGGTG GGGCTGTrAG TTTGTCTTr GTGCCTAAGA GATGACGAAC ATGCTTTTAG
AGGC
AAATCACTTT
TCAGTTT
TITTTAGCCGT
ATTACACCAA.
GATGATTTCT
TCAAGCGACC
GATGGGGTG
AACCT1'AATC INFORMATION FOR SEQ ID NO:200: Wi SEQUENCE CHARACTERISTICS: LENGTH: 345 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. 345 (xi) SEQUENCE DESCRIPTION: SEQ ID N0:200
ATGAAATTTT
GTGGTAACAA
AAAAGTTTGG
GTCAAAGGCA
GTTTTTGCTT
AGCACTAAGT
TTACAAGAAT
CCAATCCTT
TTATTCAGAT
TAGCAGATAT
ACGCGCAACC
TTGGCTTCAA
CACTGACAGC
AATGGCGGTC
CATITCTGTT
TI'GGAAAATC
CATAGCTATG
TATTGGCGAG
TACAAGAAAG
ACCAGTCCTG
CTAGCGATCG
TCTGATGACA
TTAGCGGTGG
AGTGGAGGAG
TTGTAGTAAC
CAACAGGCGT
TAGGTGGTTG
TCAAAAGAGG
CAGGTGGCAT
CTAGC
TACTGAGACT
CGCTTAGGG
TCAGGCGACT
TATCTATTTG
INFORMATION FOR SEQ ID NO:201: SEQUENCE CHARACTERISTICS: LENGTH: 573 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .573 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:201
C
ATGAAAAATC
TACATAGATA
ACAAAAGGGG
GATGATGAAT
CCAAAAGTGC
AATATCAGTA
AGAGCCTTTI'
GAGCGTATTT
GAAATGCCAG
GCTATGATTA
CCCAAGCTAA
TGAATGATGA
CGTTAGATGA
TTGGGAGCAT
GTGAAGCTAC
TTTACATTGT
TAGAGAGTAT
TTATCAI'GC
CACTTTGTCG
GAAATACTAT
TGTITTAAAA
AAAAAACTAT
GATTATAAGG
TATGTCTTCT
TTCTAAAATG
AATCGCTCAA
TGCTAAAAAC
TGATGAATrT
CTCTTATAAT
AGCGATGATG
CTCTTrTAA
GACCCAAGAG
ACAGATGCTA
TTTAAGCGTT
AGCTITGATT
ATTGATATAG
CTTATGGTCA
GITAGATTTG
GTTGTCCCCT
ATT
ATCAAGTGGC
AACCTGAACC
GGAGTTGGGC
TrATGTATGT
ATGAAGAAT'
GCACACTTrC
AAGAAAGCTC
GTAAGTI2GCC
TATTCATCAC
TGACCAAAAA
CCCTTATGGA
AAACACTCCT
CTATAAAGAC
AAGAACGGGC
TTCITTAGTA
TAAACCTGAA
TTTC'ITGTTA
GCAAGATTAT
120 180 240 300 360 420 480 540 573 INFORMATION FOR SEQ ID NO:202: SEQUENCE CHARACTERISTICS: LENGTH: 1053 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori 226 (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 1053 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:202
ATGATAAGTG
TTGAATAAAA
TTAATGGCAA
ATCAAAGAAG
AGTGGTTGGA
GTAGAAGAAG
AAAGAAGAAC
AAATTTATGG
CAAACCATGC
GAACGCTTTG
AGTGATGAAG
GATITGAAG
GGCGAAAACG
AATATTAAAC
AAAAAAGAAT
AAAGATTGGG_
GAATGTATTA
TGGAAAAAAA
AGATIATIAA
CTTTAAAAAC
AGCCTT'AT'
ATACGCTGAC
ATITATCTAA
AAAAACATAA
TTGCAAAAAA
CITTTGAAAT
TI'GAGAACGC
GGGGTATAAG
GAAAGATATT
AAAGCACTTA
ATIATAAAAT
CCTTAATGTC
ATGTTATGGG
GATTIT=GG
AGAATAAAGT
ATAC'FINFTC
GTTTCAATTA
AAGCTTATTA
AAGCGATGAA
TAGCTGTAAT
AGAATTI'CCG
ACAAGCCCTT
AATCAAAGAA
GAAAGAACAC
TTITGATAAT
TAGAGAGAAT
AGCCTTTGGC
TGATACTAGA
TACTTGGTTIA
AAACACAGAG
CTGTAATATG
TAAGGCAAAA
AAAGTCCTAT
TATCTCTCAT
AAAGGAATAA
GCTGGGGTrWT
GACTI'ATTGA
GCTAAGGTGG
CAAGAATATA
AATTTAATCA
ATTAAAGAAA
TCTAAAGAAT
GGAGCTGAAA
ACTI'ATAAAG
GAAAGAAGTT
CAA.ACCTTAT
AAACCCAAAT
TTGTTAAATA
GAAATAGATG
GTCCCAGAAA
GACAACACTA
CAC
AAATGATTAG
TACTAGGTGC
AACGAGTAAA
ACGGCTCTCA
GAGAAAAGAT
ATAAAGAAGA
AAGCTAAGT
TCCCAAATAA
GTTTATTGA
CACTTGGCAT
ATATTAGACA
CTGCTATGGC
ATCAGCTCCA
TGATAGAGCT
GTTCTAAATA
CTTGGAGAAA
CCGCTGAAAT
ATTAAAAGGT
TACTGCTCCC
ACTACACAAT
ATACTTGAAT
TTTTGAATGC
CACTGAAGAT
TTTAAGGCAA
AAAGCAACTT
TGATTGGCAC
TAAAGAATAT
ATATAAAA
TAATATGAGT
TAGTTCAAAT
AACCAATATC
TCCCAITCAT
TAAGATTTGG
AGGAATAGTT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1053 INFORMATION FOR SEQ ID NO:203: SEQUENCE CHARACTERISTICS: LENGTH: 1053 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION l...1053 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:203
ATGGCTGATA
GTGGATATTC
GATTTCAAGC
GATAAAATGG
ATCCAGCTTC
CCTACGAGTr
AATCCTAGCA
GATCAAAACA
GTGATGCAM.
GCTAAAGAAT
GTGGTTTTAG.
AI'rCCATTG
AACTCCAAAA
ATGATGGTGT
GGGGATACTA
TrTAAGCCA
AAA.ATGTCCA
GCCCTAATCG
CTAGGAATCT
ATAGCGTGGA
TITAATGTCTT
TCGCTITCCC
GGGAGTTTAG
TTTTAAAAGA
CCAGCGCGAA
AGXI7ATCAT AGAGCA ETCT
AGAGCCGTAA
TTGGGCGC
TCCGGTI'GAA
AGAAGAAATI'
AAAAAAAGAT
TGTGAGTAAG
TTCCAGTCAA
TCAAATGACT
TTCCATGAAG
TATGATTGAC
CGATA ITGAA
AGTGTGGTCG
TGTGGTCCAA
TGGGCATAGC
TITCTAAAATG
TAAGGAATTG
GGTGGAATTG
TAAAGTCGCT
GATGCGCTr
ATI'ATCCCCC
GAGCAATTGC
GTCTCTTCTA
TATGGCGAAT
CCTATGGGGG
AGACTATTAG
TTGAATTTAT
CCTGTGGTGG
ATCGTCGCTC
CGTGGGATGA
GGGAGTAGGG
CAAGCACTAT
AGTTTGAAAG
AACGATGAAG
TAGAAGTCGT
AACGCAGCGT
GCTCTITTAG
TCATGCGTTC
TTTTGATGAG
GAACGGGGGT
GGGGTAAGGG
TGGATACGAT
AGATGTATCC
AAAATGAAAT
TGAATATTTG
AT1'CATGCT
TGAGCGGGGT
AAATGTITGGA
TGAGCGTGTA
TGATGAGAAT
AACCCTCTAT
GAGCATCCAT
TA ITGTAGAA
TTTGCCTAGC
TTTAGAGATr
GAGCGCGTAT
TTTACGCCAG
TACCATTGAC
TTCTATCATG
?I'ACCCGGTG
TTCAGAAACG
GAGCGTGGAT
ITTAGATGTG
TGTACATAAG
120 180 240 300 360 420 480 540 600 660 720 780 840 900 AAAAGCGI.T AITTAGCGAG CGTGGGGTTT CAAGGGTATA GGAAAACCAT TCAAATTAAA GAAGTGGTTT ATAGCGAAAA AGAACGCACT AAAGAAATTT TAGAAWTGCT WGAAGAACAG CGCAGGAGGC AAAGTTGGGC GRTGTTATGG- AGC 960 1020 1053 INFORMATION FOR SEQ ID NO:204: SEQUENCE CHARACTERISTICS: LENGTH: 570 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .570 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:204
B
B.
B.
B B B. B
B
B
ATGCCCACGA
GTGAATTTAA
AGCCTTTCTA
CCTAAAGTCA
TITGGCTTT
?ITGGCAATAG
GTTTTAATGG
TATAAAACCC
AAGGGTTGGG
TTAGTCGCTC
TGTTAGCGGT
CCGACGGGTT
TCTTTGTGTA
TAGATGTGGG
TGTGGTATAA
GAGGGTTTAT
GGTCTATTT
GTAAAAAACG
CAGAAAATAA
TTTTGAGCT'
TGGTTTTTGG
AGACGGATTA
TGTGGCAGGG
GGAATTGTTT
CTGCAACCCG
CGCITATAAC
TGTAATAGAA
CCITI~TTTA
GGTGATCGTG
GAAGGTGTGT
GTGTTGGTTT
GCGAGTGTGC
AATGCGGAAT
GTGATTTCGC
GCAAGCGTGT
GCTATrGTTI'
ACTCTGTCTG
ATGGCACCCA
CGTTTT1'GGA
TTITATCCAC
CTAGCATITT
FICTAAATA
TAGCATTAGT
TTATGGGCGA
CGCATAATGA
TGATCTI'GCA
TCCATCATCA
TCATTI'CTAT
GAGCAATGCG
CACCCTCTTA
CTTGCTCTAT
GGGATCGCTC
TAGCGGGAGT
AATCTI'GCTC
AGTAGGGAGC
ITITGAACAA
GCTGAGTAAT
120 180 240 300 360 420 480 540 570 INFORMATION FOR SEQ ID NO:205: SEQUENCE CHARACTERISTICS: LENGTH: 1467 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geriomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1467 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:205 GTGCGTITTG AAAATTTCAT CAACCGC-CTA GCCTITTACA TGGCCACAGG GAGCGGTAAA ACGATCGTCA TTATCAAACT GGTAGAGCrr TTAAGCGTGG CTATGGGAAT GGGTTT1GATC 228
CCTAAGAAAA
GAAATTGAAA
AAAAGCGTTA
GCTCTT'ITTT
AATTATAAGG
GGGAATAAGA
F1'ATTCAATT
TGAGCGTGG
AACAACTTAA
CTT'ITAAAGG
CATGACCCTT
ATCTnI'T=A
GCTAAAGACG
GATAAAGAA
AAAGGCTTAA
CCTAAAAACA
ATTAGAATAG
AGTAAGAATT
AATATCTTAG
AT=-TTATTITT
GGCAGGGGCG
ATAGATGAAG
TGTGATACCT
ATATCATGT1'
AATACAACCG
AGAATAAGGA
ATACCGCGC
ATTGTI'GGGA
CTGAAAGCAA
TCAGCGCCAC
GCGAGTGGGT
ACGCT1'ITAA
CGTTATI'GCT
TAATGCTCGT
AAACTI'TAGC
ATTTATTAGA
AAGACTATAA
AAGAAGCAGT
ACCAAGAAAT
GCGATATIAC
TGAGCTTCAA
TGGGGTCTCG
TAAATATAGG
TAAGGATI'GA
CCATTAXAGA
ACC.AACCATG
TTF1'AGCGCG
CAATAAGGAC
TT-rTATCGT
AGATTTAATG
TAATGGGGAA
AAGACAGGCG
TTTCACTGAA
GAAACTTGGC
GGAATTGAAA
TTTAGGCATG
GTTCACGCAT
GCGCGTGATT
GGAATTAAAG
AATTGAGGTC
7rTTATGCC
CGCTTTCAAG
AGAATGGATC
AGAAGAGAGC
TGCTTTTGAC
GCTTGATGAT
AAGCGTCAAA
ACAAGCTGAA
CAAGCCT
AACGAGCATT
TATICCAAAC
GCTCCAAAAG
AGCGATGAAG
AATTATGTGA
ATTTTTAGCC
GAAAGCGATC
TATGGTAAAG
GAITTAAACG
CAAAAACGCT
TCTGTGAACA
GAAAATGATG
AATCCGGAAT
TTITAAAGAGA
AGTA.ATGGGC
CTCAACACGA
CGTGAAAAAT
TATTTCAGCC
ACTGGGTGGG
GACGCTAAAA
AACCAACGCC
ACCAAACGCT
TAATCAAGCA
AAATTGATTT
ATTCTTTA.AT
AAAGCAAGGA
TTTTAGATGA
TGCTGTCTTT
TCATCACTGC
AGTCTGTT
ACAGGGAAA
ATAAAGTAGA
TGGAAAACAG
ATGAGAGCGA
TCCTTTITAG
GTTTAAAGGG
ATATTGAAGT
GCGATAAAGT
TAAAGAGCGT
AGATTGATA.A
ATAGCACAAG
AGCTGGTGAA
AAAGGTTAGC
GCAATGCTGG
ATFI'GAAAAA
CAAAAACCTI'
GAAAGAAATC
AAACCTTTTA
AGCGCATAAG
AAAAGGGTT
GGTGTATAAT
ATTGAAGAAA
AGAAATCGCT
AGGCTATTT
CGATGCGRAA
TTTT1TCAAAA
CGATGGCAAA
CATGGATTT
CATCATTAAC
CITI'TGCCTG
GAAGGTGGTG
GAGCAGTATC
GCCTAGCGTG
ACAATCTI
GTATTTAGAG
AAATGCTTTT
180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1467 a a a INFORMATION FOR SEQ ID NO:206: SEQUENCE CHARACTERISTICS: LENGTH: 639 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 639 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:206 00 0 GTGITITAAAA ATTCCCTCI' GC'FrGTATTT
CATITCACTC
TCTATTATT
TTTAGCSCGA
CCAAGTAG
AATrTITGC C TCC TrGCTT
TGGTTAA.ACG
TATATCCT1'A
CACAAATCTA
TGATTFAT
CGTI'GAAAA
TCACCGGGTI
CCTITGGGTT
TCAATACTAT
CCATTTTCAT
ATAACATAGC
CAA.AAGCTAT
TAGTTTCTIT
ATACCCAACA
TGGTATATCA
CCTI'TGTC
AACCTATI'
TTTGGCTGAT
TTIIIGGCTT
AATTFI'ATAC
GAGCGATGTG
CTATGCTATA
AGCAGTGCCT
AATTGCTT7.17
CGAAGTGTCG
ATCTCCATGC
CCGA.AFFITA
CAAATTCTAG
AAAATCAAAC
TI'ATTC TrA
TTTITAGCTT
'ITTAGCGCTA
ACCGCTGGCT
GAAAG'ITTGC
ATTACATCGC
CCCACGGCA
TIATCACTI'G
CCCTTACGCA
GACITGTTGG
CGCACAAAGT
AGGAATFI'TA
GC TI'GCGC
RA.ATCCGFI'T
TIACCCCTCA
AAAGTTATGG
TTTAATGGC
GG'ITTTAACC
TCCCAATI-Il
TAFI'GTAAGT
TTGCATGGCT
TTCTAACGCG
GGGCATI'ATG
TAGCGGGAFr
ACTITCAAGC
TTTAAGCTTT
GCCAATTTAT
INFORMATION FOR SEQ ID NO:207: SEQUENCE CHARACTERISTICS: LENGTH: 936 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/ KEY misc-feature, LOCATION 1. 936 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:207 a.
a. a a a a.
a a
ATGAAAAGCG
GGGTTGATT
CGAAAAACCG
GCTGGGGGAA
GCGGTTGTTT
GGAAACATT
CTAAAACAAG
GAATTAGGAT
AATGCGCTT
TATAGAGAAA
TATCAAAGAJA
GCTAACCCTA
AGAGACCATG
ACCTCCTTAT
AGCGTATI'GG
ATCCTTTCTT
ATAAACCCTT
TCGCGCTCTA
CTAAAAAGCA
GCGGTAAAAC
CTAGAGGGTA
TAGTTCCTCA
CGAGCGTGAT
CAAAGATCGT
TAAAACCCAA
ATATTAAAAG
TCACCTCTAT
GCAGGCTTGA
CCCCTTTTGA
TGGTTAC LTC
ATTTAAAACT
ATCCTI'GTAA
TTIAGAACGC
TCCTTTI'CT
TGATTTAAA
GCCCTTCATT
TCAACGGGAT
AAAAACAGCG
TGTGAGCGAA
G TTTAGAC
AGTCCCCCCC
CTATAAAGAA
CACTAACCCC
TGCGTTTTTA
TITGAAGCTT
AAAAGATCTC
AGAAATTTGC
TATAAAAGAA
TATTTTITATG
TTAATCTATC
ATCCCCATTA
TTAGAAATCG
TCTAAAGGTT
GGCGATGAAG
AAAAGGGAGC
GATGGTTTTA
TACTACCCTI?
GCCCATTTAG
ACCAAACGCA
CCCAAAGAAG
TTAGAAAAAG
GTCAAATTAC
CCTAAAGTTT
CATCTA
ACCCCACTCT
AATGTATTGC
TCAGCATAGG
CTCCAAGATA
TAGTGGTGGT
CCTATCTUT
TAGGCGTT
GGTTTAATTT
TTTGTTTGCC
TCATTACAGA
TGCTTTAGT
TGGTTAAAAA
AG2'TTTATCA
AAGATI'GCAA
TAGAGGAGAT
TTTGCAAAAG
CACAATTAAA
CAACTTGATC
CCAAGAAGTG
GAGCG ETAAA
AGCCTTAAAT
AAAAGCCCT
CAACCAATTC
TAGCGGGTTG
AGATAAGGAT
AACGGCTATC
ATTGTXTT
AAATAACGCC
ATTGCCTTTA
TGATCGTTAT
a.
a a a INFORMATION FOR SEQ ID NO:208: SEQUENCE CHARACTERISTICS: LENGTH: 168 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: +ielicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .168 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:208 ATGTCTIAG GGGCAGTGAT CAGGCTTATI TTTTGTTATA AGTTAGAGGG GGTAATATTA GATTTAAAC-C GCATCAATTT CAAATCCTAT TACCCCAATA ATAA.AAATGC ATTATrATC AACAATAAGA AAAATCCATT ATCTAGTRCT TCAAAGI'CA TATI'GCIT 230 INFORM~ATION FOR SEQ ID NO:209: SEQUENCE CHARACTERISTICS: LENGTH: 684 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .684 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:209
S.
S. 55
S
S
S S *5
S
5*
*SSS
S
5555 *5 S 5
ATGCTAGAAA
AAAGTGAGCG
GC-GAACAACC
GATTATATTT
ATTTTTAATT
GGCACTTI'AG
GTTTTAGAAA
TATCGCAGCA
TI'TAGAGAAG
AATTITGGGA
GTGGGCTI'AA
GGTGAATTTG
CCACTATI'GA
TTTTAGAAAA
TTTTAATCGC
GCGATAAGGG
ATTTTAGGGC
GGGCGTTAGT
GCGCTITGCGT
GCGGGTITAA
GGGTI'TTAAA
GCTGITI'CAA
GGGGTITATI'G
GGGGGCGCAG
TITITTC TCGT
CGATAATGAA
TCCTGACGTG
TGAGTGGGTG
GAATGATTTA
TAAAATGAAT
TAATGGCGAA
TGGCGTTGTT
AGCGTGTAAA
AAACCCGCCT
TCTAAAAGAG
AATT
TACAGCAGCG
ATCTCTCAAG
AAAAATCTCG
GAGGTAGGGG
GAGGGT1'TAG
GCTGGCATGA
TGGCTAGAAA
TTGAGGGCTA
AGCATGCGCA
A~ACGATTATG
TGGGCTTI'GC
TGAAAATCGG-
AACACCAGAT
CTTATTAGG
GAGCGGCCAA
AGT ITTAGG
AAGAATI'TGA
AAGAAGCTTT
GGTTTAAAAA
AAAGCCACCC
CGGGCAGGCT
CAAAGAACAT
TGCGCCTIA
CATAGGATTA
AAAAAACTAC
TGCGTCTAAA
GCAATTGCCT
AATAAAAAAT
GGGGCTAGAT
GACGCATGGT
CAAAITGCCT
TTTAGAGGGC
GCGAATTTTT
120 180 240 300 360 420 480 540 600 660 684 INFORMATION FOR SEQ ID NO:210: SEQUENCE CHARACTERISTICS: LENGTH: 267 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNZA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE:_- ORGANISM: Hei:z:=acter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .267 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:210
ATGCTCAAAA
ATGGATGGC'T
TTGATCGCCG
ATGACTGAAT
AGCATTAAAT
ATGGCGATAA
ACACTTTCGC
?I'ACCAGTCG
ACATCACCAA
TAGAAGGAGA
GATTCCGGAC GCTATI'TAG TGGATAITGA CTCTGAAGTG CGTAAATACA ATAAATI'CAA GGTAACTAAA ACGGACAGAA TGCGCGGCGT ACCTTATAGC GGTGAATATT TAACCACCGT
CCAATCG
GATGCCTA.AA
AAACCTGCCC
TGAATCCGGC
AGTGAAGCGC
INFORMATION FOR SEQ ID NO:211: SEQUENCE CHARACTERISTICS: LENGTH: 333 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: *oo* NAME/KEY: miscfeature LOCATION 1...333 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:211 GTGTTTGAGC CGGTTATCGC TTACAAGCTT TTCCATTCCT TTGTGATTTT AGGGTGCGCG ATTGAAACTT TAACGACTAA ATGCGTGGAA GGCATCACGG CTAATGAAAA GATTTGCCAC 120 GATTATGTTT TTAACAGCAT TGGCATTGTT ACCGCGCTCA ACCCTCATAT CGGCTATGAA 180 AAATCCGCTA TGATCGCCAA AGAAGCCTTA AAAAGCGATC GCTCTATCTA TGATATCGCT 240 TTAGAAAAGA AAATCTTAAC CAAAGAGCAA CTGGACGATA TTTTCAAGCC AGAAAACATG 300 CTAAGYYCTC ACGCTTTCAA AAAGCATAAA GAC 333 INFORMATION FOR SEQ ID NO:212: SEQUENCE CHARACTERISTICS: LENGTH: 195 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular 99 (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 17..195 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:212 ATGTTGCGTT TATTAGCCCA AAAAAGCGCT ATTAAACTCA TTCTTATCCC CCCAAGCGCG AACGCTTTAG GCATCGCTTC TATTTGCGAA TTGAGCGAAG AAGTTTTTGA ACATGAAAAA 120 ATCGTAGGCA TTCGCGCTCA AGGGGATTTC ACTATCAATA GCGACGATAG GGGTTTTTGG 180 GAAAGACGCT GTCAG 195 INFORMATION FOR SEQ ID NO:213: SEQUENCE CHARACTERISTICS: LENGTH: 804 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .804 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:213 09 0 000* *000 0*
I
09
.SP*
*1 *I I 0
I
III.
I
ATGAAAAAAC
ATTGTGTTAG
GTTTCTCAAG
AATAAAATAG
AATATAGAAA
AATTI'GCCTA
AATACCGCTA
CAAAA.;AGAZA
GAAAAACGAG
TTGCTTTCCA
GGATTGGATT
TITATTATCTT
T1I7TGTTTTT11
TCATCATTGT
TTCTTTTACT
TGGGITTT
GTAAATTCCC
ATACTATCAA
AAACACAAAA
AGGACTTTAA
ACGAAGATGA
CGCAACCTCC
AACTTGAAAA
GTrCTTCTTC
GTGAGAAGCT
CATTGTTITG
CTAAGTTTTC
CAAGGCTAGG
CTTIAGAGCAT
TCTTTTI'TAT
CACTTCATCT
TCAAGTGAAG
AGATTTAGAT
TAAAACACI'
AAAAAACCGC
CATITCTATA
AGAATGGGCA
ITTTTCTTCT
CAAATCCTTr
CCATCCACTT
TAGAGAGCTA
ATCA
AAGATCGTAA
GAACAAGAAA.
TATTTGT C
CCAAACGATG
GATTTTAATG
A'ITAAACCAC
CTGGTGATT
AAAAATAGCG
AAACCTAGTG
TTTGAAGTTT
TI'AAAAGCTT
TCTCTTTTrr
GTGAATGCGT
AAATTGGCTT
TCAAAGAAAA
AAGCTTACGA
AAACTAAAAG
CGCTAGTGCA
AAAGTCCATT
TAGCGTCTCG
TITTCTCACAT
TTTCTITTTGG
CTTTTTTATC
TTTCAAGTTC
GCTCTCTAAT
CTAACAATTC
AATTATTGTG
AGCTGTTAAT
AGGCATTIAAG
CGTTAATGAG
AAAGTTACCA
TTI'CAACTAC
TATTAGCAGC
AAAATCCAAA
TTCTTTTTCC
AAGGGGAATA
GCTATTTCC
AGGATTAATC
GCTTGAGTFT
120 180 240 300 360 420 480 540 600 660 720 780 804
S.
I I 0*4 C INFORMATION FOR SEQ ID NO:214: SEQUENCE CHARACTERISTICS: LENGTH: 300 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .300 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:214
ATGGGAGCGA
AGCGAAAACG
GTCATTGTAG
GATGAGGTGT
ACGATTIT
TACCGAG ITG
AAGAAGACAT
AAAAAGACCG
TGTTGATI'I'T
TTAGCGACCA
TTACGCGCAT
CATTAAGGAT
AAAAAAGGCC
AGGCAAGGGC
GGAAGTCGTT
CAAATCATCT
ATTTAAAAG
ATTITAAACG
GATGAAAACA
AAAGATTA'TT
TAACTTCAGA
GCATCAATAA
CTITAGAAAA
TTCAAATCTT
ATCTCAAFI'T
CAATCCTAGA
TTCI'CTAAA
TTTAAAAGAC
TAAAGACAAA
AAAACAAGGA
120 180 240 300 INFORMATION FOR SEQ ID NO:215: SEQUENCE CHARACTERISTICS: LENGTH: 240 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .240 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:215 GTGATGGACA AACTCACTAA AAGCTTGCAA ACGCAAAAAA ATCAAGCCCC AACAACTCGC TGATTTCATC ATTAACGAAC ATI'TIGGCCC- ACATGGAARC CCCTAATGCG GCTGAAACTT ATGAAAGCCG AGAII'TCCAT TAGAATGGCG AATTTTAGGC ACTFICGCTTA TTTAGGCAAA ACCCTCAAAC CATCGCCTTG TGAGCTATTT CCCTGATGAA GAAATATCGC CCCAAGTGGT
S
INFORMATION FOR SEQ ID NO:216: i)SEQUENCE CHARACTERISTICS: LENGTH: 615 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicczacter pylori (ix) FEATURE: NAME/KEY: min=-teature LOCATION 1 ic (xi) SEQUENCE DESCRIPT-I:::: SEQ ID NO:216
S
55
S
ATGCGGTATT
TCTAAGCACC
GCCAATAAAA
AACACGCCGG
ACTGAAGTAA
AGCATITGTT
AAGGTGAGCT
TAGGGAAAC
ATIATCCTT
GCTATI'AGGA
GATAGCGAGC
TTAGAAGCGC
CTIT CTAA
AAAGAGAAGA
TTTTCGCTT
CCCTTTATAA
TTAGCCAAAA
ATGGGGATTT
GCCACCTAAC
ATGAAAGAAA
TTGAACCCTA
TI'CAA
717,1--A7.7
GCAAC::-
GACTTTG;LAT
TATGATTAC
GCTCAGCCAA
ATGTTCGGCC
GTTTGATGAT
CCCTGAATAT
AAATGGCCTG
TGAGCCTTCT
17TTTCATGA
AAGACTAAGG
GC-CTTGCGCC
GGCACGATCA
AAAGTGGGCG
AAATGGATrG
ATTGTITTAG
GTGATCCAAA
ATrTCTTTCC
TTGCAAGT
CGCFTTT
AGCGGATCCG
AATI'CAGACT
AAACCGATAA
ATATTTACAT
CTGCAAGGGA
GGAGGGATAT
GGTITCAAAA
AAAACTI'GAC
TAGAAGACAA
TGTTCT'GC
ACAAGAAGAA
CATTTACATT
AGACCACAAT
GACTAAACGG
TI'TGTITGGC
TI'ITAAAGGT
AAGCGGGGAA
TCAAAAAATT
TGAAAACGCT
120 180 240 300 360 420 480 540 600 615 234 INFORMATION FOR SEQ ID NO:217: ()SEQUENCE CHARACTERISTICS: LENGTH: 372 base pairs TYPE: nucleic acid STRANDEDNESS; double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .372 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:217 a. a.
*aa.
ATGCGCAFI'G
GTCGCTCGCA
AACCTCTATG
CCCATTITTAG
TTAGAAACGA
GGCTATTCTA
AGCTTGAAAA
AAGAAAATGG
TCGGTATTIW
A.AATGCA.AGA
GGTGGGACGA
GCAACGTGAA
TGAACGCTAG
AA
CGTGATTTCT
AGCTTTCACT
AGGCACCATT
AGAGGGCAAG
TGCCGGGAAC
AGCCTTTGGC
CTAGCCTTI'A
AACGATCAAG
AATGGCGAAA
CTCAAGTT21G
GCCCTAACCA
GCGGGCGATG
GTAACGGGGT
GCTTAAGGAA
ACAGACCCCT
GGAAAATCAG
ATCTCATTTT
ACATGATCAA
GGTAGAGCCG
AATCGGCGGT
AAGSGGTAAC
GCACAAATAT
A.ATGCAAAGA
AGAAGCCATT
INFORMATION FOR SEQ ID NO:218: SEQUENCE CHARACTERISTICS: LENGTH: 279 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geriomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1l>.279 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:218 a..
GTGGAAGCGC
CAAGAGTTCG
GCCGCTCGCA
GCTAAAGAAG
AGCCATTTCG
GTTATTAFTA
CTCACTITGG
GTCCTI TAAG
TGTITTGAA
CTTCCAATTT
TGGGGACACT
ATCGAATGAT
CACCTATGCA
TTTGGGCGTG
AGGAATGAGG
TCATACTI ATG~rCATGT GTGGCGTCTI' TAAACACCTr AGAGCGATGA TGGGTGGGGA GT'FrATGC ACAATTTGAT
TATAGITTC
GGGAGTrTIA
TAAAATCAAT
ATTGCAATTG
TTCCAACGCA
INFORMATION FOR SEQ ID NO:219: SEQUENCE CHARACTERISTICS: LENGTH: 642 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 642 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:219
GTGGAGGAGC
TTTTTGAAAG
AAAGAAGCCA
ACGAATTFrAG
ACTI'TCAAAG
AATAGAGTCC
TITGATGAAA
AAAGACTTTT
TTIGCACGGAG
GTATTCAATT
AAAAAAATCT
TAGCTAAA'T
TTCTCTI'AAG
AA-kAAGAAGC
ATTTTGATAG
AAGTCAATCC
ITAAAAAAAT
AGGGTAAAGA
TTACTTTCAA
AAACAAGAGA.
CTTATGATCC
TTTATACGAT
GATCAACA.AT
TCTCGTTGTT
GCTAGAAAAA
TTTAAAGCG
CGATATTATC
AAAGGATTTG
AATGGGATTG
AAGCATCAGC
AATT1'TATGC
TAATGATCTT
TACATGTGAA
AATAATAACA
TTCAGTTCGT
GAAAAAAACA
ACTATCAAAA
AAAGATGAAG
AAGCATTACG
AATGTAGAAT
ACGACCAACA
GATGATAAGC
TTGAAACACA
GCGGTATATC
ATAAAAAACT
ATGGGTCAGC
CTCCCAATGG
AI'TGAAAGA
TTTTTGACTT
ATCCAGTTAT
TACAGATCAA
AACAACGCTG
TATATAATGT
TTAGCACCAT
TA
GAGAGGCTTT
AAATGACGAT
GCTTGTTTAT
CAAGAAAGTA
CGTGATTGTC
TGAAAAAATC
TCCTGAAGTG
CITTCTATCA
TTTATTGGCC
AGAGTCTCTC
120 180 240 300 360 420 480 540 600 642 INFORMATION FOR SEQ ID NO:220: SEQUENCE CHARACTERISTICS: LENGTH: 234 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY:-misc-feature LOCATION .234 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:220 GTGGGGGGCA TTGTGGCAAA CATGAACGAT CTITCAACT ACATGGI'GA ATGGGTIGT ATCTTITFI'TC TAGCGCITTA GATTTGGGCG TGAAAAAAGC GCGAGCTCTI' GCGCTTATCC TAAATACGCC CCTAACCCTT TAAAAGAGAG AACGGCTCTT TAGAACCAAC GAATGAAGGC TACGCTTTGC CAAACTCTCT
GAATTTACTC
CAFI'AATCTA
CGATITTAI'
GTRR
INFORMATION FOR SEQ ID NO:221: 236 SEQUENCE CHARACTERISTICS: LENGTH: 531 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .531 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:221
ATGAAGAAAA
GTATTCACTC
TTAAAA'ATTC;
TTGGAAG'ITG
TAGAAGTTT
GAAAAACq_'A
GATGGGAATA
CGATTAAAAA
TGGATGGCAA.
GAAAACATGT
TTTTAGTCGT
GAAAAC ETGG
AGCGGGTTGA
CTGATTTGAT
AAGTCAAAGA
AATACGAGTT
TATCAAGCTT
CGCCCACTAT
ATCCAAGAAA
CATTCACAAA
CATITCTGAA
TCTCTCTTCT
TAAAAATATC
AATCATTFI'A
WAGAATTTCC
AAAATCATCA
TCRCCCAAAG
GTGTTTAATG
ACCCTI'CAA
TTATACTTAA
TTCTTCCATC
CG TTATGGCA
GACGATAAAA
AGGAATCAAA
ATTTGCTTT
CCAGGAAAAT
TCATTATCTT
ACGGCATTCA
AACTCAAZTAA
AAAAACCCAC
TTITGGGCGGT
ATAAAGCCAA
GGGGAATTTT
TAAAGATGTT
GGCGTTCAAT
G'il"GTGCA
CATACAAAAT
CAAGCTTTCT
TAAAAAGCGT
GTCTTATTTT
TATCTTTTTT
CCCTAGAAGA
AAAGTCCAAG
T
120 180 240 300 360 420 480 531 S S
S
INFORMATION FOR SEQ ID NO:222: SEQUENCE CHARACTERISTICS: LENGTH: 774 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 774 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:222
GTGTCATGTT
GTTTATGCGG
ACTATrACA
TCAAACGATG
GCGAGAGAAA
GTTTGTAAAT
AACGATCT1'A
GGGTGTATGC
AAAGATCTAG
TTAGGAGGGG
GGGGAGCGTC
GGGGGTTAAT
CGGATAAAAA
CTGATGGCTG
ACGCAAGAGA.
TAAACGATGC
AAAATGCTT
TGTCAGCAAC
AATATTATTC
A'FTATITT
AAAAAAGCGG
GGCAGAGCAA
TTTCACTAGA
TGCAATCTTA
GAGCATTGAA
TGAAAAATGC
AGAATATI'AC
TTIT1ATAAC
TAAAGCTTGC
TGGTGAAGGC
TTTTTAGGGT
GATCCTAAAG
GCTAAGAAAT
AGAGAGGT
AAAGCTCTTG
AAGGACTI'AG
TCTAAATCT'
GATATGATAA
GAGTI'AAATA
GTAACAAAAG
TTTGTGITTG
AGCTI'ATAT
ATTTTGAAAA
ATTCTAGTGG
AACACACCC
CAGAGTTIA
GTAAGTTAAA
AGGGTTI'GAA
ACGGTGGAGG
ATTTCAAAAA
GGGGCGTIGT
TTCAGGTATA
AGCTI'GCAAA.
TAAAGCCATA
TACTGCTAAA
'TTTAATGTA
TAATGTTGAA
AAAAGATAAA
GTGTTCTAAA
AGCTFI'TGAA
120 180 240 300 360 420 480 540 600 TATI'CTGCCA AAGCTTGTGA. GTTGAACGAT GCTAAAGGGT GTTACGCTCT AGCAGCGTT TATAATGAGG GTAAAGGCGT GGCAAAGGAT GAAAAGCAAA CGACAGAAAA CCTGAAAAG AGTI'GCAAGC TAGGATTAAA AGAAGCATGC GATATTCTCA AAGAACAAAA ACAA INFORMATION FOR SEQ ID NO:223: SEQUENCE CHARACTERISTICS: LENGTH: 225 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .225 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:223 GTGGCTCTCA CTTTGGGGGC TAGAGGGGGG GTGTAITTGT TTCATTGATT ATT'ITAAAAC TTCGCCCTTT AGAGCGCGTT GGAGCGTTI'C TCGCTTCCAT CCCTGTGCAT GTCGTGATGA GGGGCGGGCA TTGCGTTAGA AAATTAT1'A CTGCATGATA GTGGGGGGAT TATCCCACGA TI'GAAACGAA AGGGCGCATG AAAAAACTCC CGGACTTGAT
GAATA
INF ORMATION FOR SEQ ID NO:224: SEQUENCE CHARACTERISTICS: LENGTH: 1263 base pairs TYPE: nucleic acid STRANOEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1263 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:224 SR. S
ATGAAAGGT
TITGCAGAGG
ACTATCATAG
CAAGCTCAAG
ATTAGTAGTA
CAAATAGAGA
GCACAAAATT
GCTCTTACTA
TAACAATGAA
GGGAAACTCC
GCAAAATGGT
TCAATCAGT
GTGCTATCAC
GCATI'AGATA
TGTTAAGAAA
ACAATAAGAT
AAAAIPAG'T
T'FrGATTGTC
AGATAGTATC
ACAAAAAGTC
TTAGCCAAT
CAACTATGAG
CAAATACTTA
TGTCAATCI'
TTAGCATGC
AATGACCCAG
AAAAGATACG
AATAACATGA
CCTATGCAAG
AATfl'AAAGC
CAGCAACAAT
AAAGATCTCA
TITTATGTTG
AAACCCATGT
AAGAGA'ITAT
TAAATACGAC
'I'I'TACAAAA
AAAGCATAGA
GCCCTTGGCT
ATAACCTAAT
TAAAAGCGTG
AAGTCAAGCC
TI'CTAAGGCT
TAATTCTTTG
CGCTCAGTAT
AAATTGGAAC
TAATGTCAAT
CACCAAAAAT
120 180 240 300 360 420 480
GGCGAACAAA
GGCTATGG-AA
TTGTGTAAJA
AATAACCCAG
AATA.AGCAGT
GAGTTTGrGTG
GAAAATAAAG
GATAACGAAT
AAAGACGCTC
AAATATTTAA
AGCGAGATTA
AACCATATAG
TACTI'TCAAA
GAT
CCCAAACCGC
ACATGCAATC
TGGTAAACGA
AAGAGCAAAA
TAAAAGATAA
TAACTGACCC
AGACAGGTAA
TAGAACA.AGA
AAAGCCAAGC
AAGAAATTAC
TGACAGATGA
ACGAACAATT
ACCCTAATGT
AAGAGATGTG
ACTTGCTGGG
TAGTAATTAT
ACGAAGAT
ACTTGACCCA
TACAGCTAAC
ATGCGACCCT
AATCCAAACG
CTACGCAAAT
CAATCAAATG
TTATTTTAGG
AACGCAAA.AA
TAAATTTGAC
CAAAATCTCA
GAATTGAGTG
GAAAGCGAGC
TTGCTTAGAG
TTTCTAAAAA
CATAATAAGC
ATTAAAAATG
CTCACAC'ITG
TTCAATCAAA
CTCTITI'TA.A
CAAAATAATG
AGAATAAACG
CAATTTGGCT
TTCAGTCCAT
GTAGAGCGTG
AAGCTCTTTT
TAAAGAAAAA
GACTTGATGT
AAGGGATACA
TATTTAGGAC
ATTTAATCAA
GGATTAAATT
ATCAAACAAT
ATGGCTI'TGG
AAAGAGAAAG
TTCCCATTTT
TAGTGGCAGT
GGGGGAAATG
AGCAACAGGC
GGTTAATGAT
CCTACAAACT
TTATI'GCACA
AACTCGCTTA
AGCCTCCA)AT
ACTTACTCTA
GGCAATGCAA
GGAAAAAGAA
AGCTAGAATA
TAGTATATGG
540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1263 INFORMATION FOR SEQ ID NO:225: SEQUENCE CHARACTERISTICS: LENGTH: 330 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA Jgenomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .330 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:22S
ATGAGCGTGA
GTTCAAGTGG
GATTATGATG
ACGGCTATGG
ATCGTCGTGC
GGCTTTTTGC
A'FITATrTGGA
CGGITATGAT
CGGCGGTGTT
TGAATATGCA
CTI'TAGTGGG
rTTTGCCTTT
ATTGTTAAAA
CCTTTATGTG
GTGCGCGGGG
AACCATCACC
AGCGTTTT1T
TI'CCCTAGT
CTCGCTGTGC
GTGCT1'GTAA
CATTGCGGT
AACCACTATG
GTTGATATI'A
CITTAGCGGT
CCTTTAGGGT
TTGGGCTTGG
GGCCATCGCA
TTAACGCTTr
TATTTTGAGC
ATGCGGGAAG
AGCGACCCCA
TGTGGCGTrT
AGCGATTAAA
INFORMATION FOR SEQ ID NO:226: ti) SEQUENCE CHARACTERISTICS: LENGTH: 336 base pairs TYPE: nucleic acid STRANDEDNESS:. double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: 239 NAME/KEY: miscfeature LOCATION .36 (xi) SEQUENCE DESCRIPTION: SEQ ID NO226
ATGCAACTAA
AAAAAAACAA
CTAGCTITGG
TITTI'TATA
CCAAAACGAT
ATTCTACCTC
GCCCCTTACA
GGAGCTTTGA
GGCTGTTGAT
GCGATGCGTG
TTGGCTTTAA
ATAGGGCGAA
AAGCGCGCTG
TTTAAGCGAT
GAGCGAAGAA
GTTTGTCAAA
GATTGCCTTT
AGATTTTAAA
TTATATTTCC
TTAATTTTTA
ATTTCTATCA
ATCGCTCAAA
TTTGATCGCT
AAAGCC
GTTACTTTAT
TTGTCATGGT
GCTACAATGA
AAAGCGTAGC
CACGTCATCA
TTATCCGAA
TTTTTTAGTC
AGCGAAAGAC
CATTTTAAGG
ACATGTITIT
INFORMATION FOR SEQ ID NO:227: SEQUENCE CHARACTERISTICS: LENGTH: 261 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 261 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:22-7
GTGTATGCGC
TCCAAATTCG
CGCGTGGTCT
CTAACTATCA
AAGGCTAAGC
TCATGGTGGC GTTTTTTGCT TACATGAGTT ATTGCTTGGG GTATCAATTC TTTCTAAAAA CAACATTTCA TCGCTCTCAT CGCITI'TATC AAGCTGTGTG CTGTGCTAAT CT1GTCGCTC AGTAGCCTAG AGTIGCGTTA CTTCTCACCC TAACCATGCA TI'TGCCCTA ACGCTTATCA*TCCTCTTFIT'-
CTTTTIGTAT
CGTTGATGA G INFORMATION FOR SEQ ID NO:228: SEQUENCE CHARACTERISTICS: LENGTH: 1257 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION .1257 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:228
ATGAGGTCTTI
GCGGTFI'TTA
GAAAATACAG
TCAGTGGGCT
TATCGTTI'GA
ACCCACTATr
TACAAGGGCG
AATCCTGTAG
AGCCCGCACC
AAATTTTTAA
TI'AGAAGATG
TCCAGGCCTA
GTTAGAGTGA
GAAGATGTGA
ATCGCTCAAA
TATTATAAAG
GCCATGGGTG
GACTCTTCGG
GTGTATCGTT
CAGTICGTGG
GATAAAGATG
GGATGAAGAA
TAGGGTGTITC
ACGATAAGCT
TTGAATGGTC
AAAAAGACTC
ATGATGAGGG
ATAAAATTTC
A.AAGCGTGTT
CAAATCCCAG
ATGTGGGGGC
GGCAAAAATA
GCGTGATAGT
GTCAAAACCT
TAGCTTATCG
CCACCAACAC
TCGTCGCCGT
AGACCTCTGA
CCTTGATCCA
TTGAAGCCAA
ATAAGGACAT
GTTTAGAGTC
AAAATACTTC
TTCTACCAGG
CCCAGTGGTC
TAAAGTCGCT
CAAGCT'AA
GT1'AGAAACA
CAAACTTTCA
TGCAAGCCTI'
CGTTTCTAAA
TGTAAAAAAC
CCGCTACCAA
GGAGGGGAAA
CACACGACAA
CATTTACGCT
TTCCTATGTG
AGATAAAACG
TAGGCCTGAA
ATGGGAAAAC
CTCCAAAACC
GAAAGTGGGC
GCACCCAAGC
ACGCTTTTAT
AATCATACTT
CATTCCATTA
GACACTTATG
AGAATCGCCA
GAGAGTTCCT
GAACCCATTI
GAATACCCTA
TACATCATTC
CGCTTATI'CG
ATCATCGCCG
ACCAAAGACT
ATTGAATTGA
TCCAATAACC
GATAAGATAG
CATC'ITGAAG
GCCCCTATCA
AACCCAAGCC
CCTTTGCGTT
GTGGCTTATC
AAAGAAGTGC
TGCAAAGTAG
TTTCAGCCCT
AAACGATTAA
ACATTGACGG
CCAITAAAAA
ACACTTACCA
TAGTAAAAAC
AAAGCGTGAA
AAAGGCAGAA
TGGAG7='T
AAAATFTTCAT
TGCCCAAAGA
GTTGGGATAA
GCAACGATAA
AAAAAGACAA
GGGCGTTACC
TCACTAAAGG
CTAAAATAGC
TTGGGAATAT
GCTATCAG"-T
GTTTGTIT'T
TGTGGTATTA
TAGTAATCAA
CGATGTGAGT
GTTTGTTTTG
CCCTI'ATGCG
ATTAGCCACC
CTCCTTTATC
AGTC TTTGG
TAAAGACGGC
TGATAAAGAT
GGGGGATAAA
AATCGCTA.AT
ATCCCCAGAA
ATACAAATTC
TCTCACTCGT
CAAAGAGCCT
GACTATTCAA
CACTTATGCG
CACACAAAAC
GGTGAGCGTG
AGAGCGC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1257
S
*9 StPS a a
V
INFORMATION FOR SEQ ID NO:229: SEQUENCE CHARACTERISTICS: LENGTH: 378 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .378 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:229 *sts 0* S a
ATGCTTCCTA
ATAAAAGGAT
TITACAGGTT
TTA.ATGATGG
AAGAATITIA
GCTTTGGFTG
GTCCCACAAG
CTAAAACACG
TGAGTATGGG
TATCCAGTGA
GACTTAATGA
TGGCAGA.AGT
GTAATGGTT'
TAAGACTC
CATTAGAGAT
A.AAAATTA
TTTGTITTCT
AGCATTAGGG
GCTGAAGAAT
TGGTAGCAGC
CCGAACAAGC
GCTTCTFI'GT
ATGATATTAA
AAAAAATTTA
GGATTCGATA
AAATCAGACA
AAGAACTTAC
TGGGTGGCGG
ATII=rGTT
ACTTGCCTAT
GTATCAAAAA
AAACCACTAA
ACAACCAA.AA
AACAAATCTT
CTTCCTGATG
GGACAATATC
CATGGGATCT
TAAAATGAGT
INFORMATION FOR SEQ ID NO:230: SEQUENCE CHARACTERISTICS: LENGTH: 216 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .216 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:230 ATGGCGAACA TGATGATGGC AGCGGCCATG 'FIAGGGATTG TATGATCAAG AAAAAGTGGA GGCTTATI'TA GAGGAAAAAG TTrGGCGTGT CGGTAATGGC CAGTTTTGGT TATCGTAACC CGCTGGAAGA CAGAAGTI'AT TTATGAAGTG ATTGAA A'FTCTTG CCC GATTGAAGGG GCTATCTAAA CACGGCAGAA AAGAGAFI'AC CCCTAA.AACC INFORMATION FOR SEQ ID NO:231: SEQUENCE CHARACTERISTICS: LENGTH: 333 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .333 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:231
ATGGCCGGGC
GACAAGGTGG
TAAAGGTT'
AGTFAGAAG
1'TTGGCAAG
AATAACATCG
'TGTITTGAT
ATGCTAGCGA
CCCTCTCCAT
ACGTITTATC
TGGTGATCCA
CTTTTCGCA
GGTGCTGCTC
AATCACTTGG
TGTAGCCATI'
CAGTATTCCT
TTTGGTGTITT
GAAAGAAAGG
GCCAGITATG
CTAAAACACA
TCGGCGATT
AA.AGACACGC
GTGTGTTCAG
CAT
AA.AGCTTI'GT
CAGATTTTAA
TCTTGCTCAA
CCCTATCGCA
CGCTGTTAAC
TI'CTAAATI'A
CGCTI'AAAA
ACGCTACATG
TAACCCTATT
CGCTGTI'ACC
INFORMATION FOR SEQ ID NO:232: SEQUENCE CHARACTERISTICS: LENGTH: 426 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .426 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:232
ATGATTACGA
ATI'AGCGATA
AATATCGGTA
TCCCCTAAAG
AGCGGTATTA
AAAGAATTGC
GTGAATGAA
GTGTFI'
TCGTTAT'GC
TTAAAATGGG
AAAGAGTCGC
ATAAAAAAGA
TCAGCATTCA
AAAGCTTAAA
AGGRTFI'GGC
AAAAGCGGGG
GCTTATI'AA
CAAGCTCGCT
AGAATACGAG
TGCCCCC'ITA
AGATGGGGCG
TUI'RRTFI'TA
AATATAGTCA
GGAGGTCAAT
CAAGCTTTCG
CGCTTGAGTT
AATGAAAGCA
ATTTTAATCA
GAAACCACAG
AAGYCGATAT
GGGGGGTITAT
GGGCMA.AGGT
TAGAGGAATI'
CGCGCGATTT
ATGTGGGGCG
ATTTGTATTA
TTTTACGCAC
TGGTITTAGGC
GGTGTATTIT
GCTTAAAACA
AATCGCTCTG
TGGGGGCATT
CGCGAGCGAT
0* 0 :00 I 0 INFORMATION FOR SEQ ID NO:233: SEQUENCE CHARACTERISTICS: LENGTH: 189 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .189 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:233 GTGAWF1'TCA ACGCTAAAAA TATTTCAATr GATAA TTGG TAGAAATCAA TAATCGTGTG GGTTCTGGAG, CCGGGAGAAA AGCCAGCTCT ACGGTFITGA C'FITGCAAGC TTCAGAAGGG ATCACTAGYA GTAAAAATGC GGAAATTTCT C'TrATGATG GCGCCACGYC AA'ITTGGCTr
CAAACAGMG
INFORMATION FOR SEQ ID NO:234: SEQUENCE CHARACTERISTICS: LENGTH: 930 base pairs TYPE: nucleic acid STRANUEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE:* NAME/KEY: misc feature LOCATION 930 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:234 ATGCGAACGC TCA'ITCTGTC GCTTCTAAAA
GAATGCCAAG
GCGGGGTATG
CCTCAAAAA
AT1'GTAGGGC
GTGGTGCGTA
TTAAAAAAAA
CTTACGCCTT
GATTTAGCGA
TATGCGCCTC
GATT1'GATTG
AATCGCACAC
GGATTGTTGC
GATTTTATCC
TIGCCCGCTA
AATATTGGAG
AAAAGTTAAA
GGGCGAGTTC
CGAAGAAAAA
C'FTATGAGCA
TCCCTTTAAA
CCCCTAACAG
TAAAAGAAGT
ATITI'AGCGC
ATAAGCI71TT
ACACGCAAAT
GGCATGAATT
AATTTTACAG
ATAAGAAAGA
TTAATATTTA
GGATTTCRCC
GCGTI'CTFI'A
AGCGATTAAG
TTTAGAGCCG
TCATTCTAAT
TGAACATGGT
CTI'GGTF1'CT
TTCATCATTG
GCATGCTAAC
AGGGGGCGT
YCCTYCGAGT
TATI'GATGAA
GAGCGCTCTA
AAACAACCTT
TGGGAATTTA
CATGCGATIT
AATTTGAGTG
AAAFITCAAG
TATTTGAAAG
GAAGTTAGCT
TTATTGGATT
GTGAGCGCGG
TGTAAGGAAT
CCTAAAGATT
GGAGGGTGCG
TTTAGCGCAG
TTGCCTI'TAA
GCGTATCAAT
TTAAGGGTGC
ACGGCGAGTC
TAATGGGCAT
CTAATCATTG
AAATITTTAGG
ATATGGCTT
GGCGTGAAGG
TAGAAATTTT
CTTCTAATGT
ATAGGGCTAT
GCGAATACCA
GTCTFI'TAGG
GGGGCGTGAT
GAGAAGAATT
TAAGAGATGA
TTGTGTATGG
GTGTGGGGGT
GCTFI'TAAAA
CGTCTTGAGC
GGTGTGTATC
A.AAGCGTGTG
CTI'GTGTGA.A
AGAGCAAACT
AACGGGAATT
TTTAGCTTI'G
AACCGGI'r
CATTTCTAAA
TAAATACGCT
TGGCACGCCA
ATGCGGTTTG
CTTAAAAGAC
AGTGRCTT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 930
CTATGATT'A
INFORMATION FOR SEQ ID NO:235: SEQUENCE CHARACTERISTICS: LENGTH: 564 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylont (ix) FEATURE: NAME/KEY: misc_feature LOCATION .564 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:235 see
GTGGCATGCA
CCTATI'GTGG
AACGCCCCTA
GCCCTGAAAC
TTGATTGAAG
ACTCCCTTAG
GCTCAAAAAA
ATCCATI'CGG
GCATGCACAT
CAAGCTAAAG
ACACCGCGAG
CGCTCTGGCT
GCGTGATTGA
GCCAAGCATT
ITFI'AGTGCT AGGGACAAAA AACAAGGCTA TTTGAACATT AAAGTATIT AGAGGGCGAA AGATFITACC
CGAAGTGATC
TTGAGGGCTA
T'T~CATGGGG
GCGATGCTAT TGTAGAATAT TCCCTAAAGT GGAA TTCAT AATGGCTCAA ATI'G
TTAGAAGAGA
TTAGCGATCA
GCGACGATTC
TCGCATTTAG
TTGTI'AGAAA
ATTTTAGGTT
CATTTTGCCC
TTGCAACAAA
GCGAGCGGCG
TGCAAAAGTA
AGCGGCAAGT
AATCCAACGC
CTACTTCTCT
CTTGCATGCA
GCACGCAT ET
[TCCAACGCC
AATACGCCCT
ATGTGATCTG
TTCTAAAATC
GGAAGATAAA
CTATGACAAC
TITTTGTGCCT
TTATTAIFI'C
TCCCTTAATC
CCCCCTACTC
TAAAAACAAT
GCTAGAAAGA
120 180 240 300 360 420 480 540 564 INFORMATION FOR SEQ ID NO:236: SEQUENCE
CHARACTERISTICS:
LENGTH: 426 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .426 (xi) SEQUENCE DESCRIPTION: SEQ ID NO;236 9 9.
4* a C 9* Oa@#
GTGTTGTGGG
TCTAAAAAAT
AGAACCCCAC
GAACCTTTTG
TTGAGCGGTT
CAAGCTGTAG
CCCCTT1-1TA
TATCAG
TGCTATATr
CCATGCTCTT
GAGCCGGGGG
AGATGCCTTT
TTTTAGAAGA
GGGTCGTITG
GCTTGCCTTA
TTTAACCAGT
TGTGGATAAC
GCTTGGGATC
TAAGGGGCCT
CATTAACCTT
CATCATTTCA
TTTCATCGCT
TATTTATTT
GCTAATAAAA
Tl-TCTTTCTT
TTTGTTTTCT
TCATTAAG-C
TCAACGCCTT
TTTTTATTCG
GCTCTFI'GAT
TCCAAGGCTT
TTGCGTTGGC
TAGGGCTATC
CCAAAATACG
TAGTGSTGAG
CTATT'FFTTA
TGTTI'TGTGG
CCATCATGCA
TTGT1'ATCTT
GCTAGTGFFI'
CCTTATTTTG
CGAT TI'TCG
TGCTGGTGGG
120 180 240 300 360 420 426 INFORMATION FOR SEQ ID NO:237: SEQUENCE CHARACTERISTICS: LENGTH: 258 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genornic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .258 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:237
ATGGCGTGTA
GCTTTAGGCT
CCAAAATCTT
GAAAGGAAAA
GCATGCGAAG
AATTTGCCC TAAGATCAGA AAAACAGATT GGATITrAT TTATTCAGT TAATAAGCTA GGGTATGCGC CCAAATTCAA CACGCCCTCT TTCACGCCCT AIWGAAAAGC CTAACAATAT AGCGTTI' AT AGAGTI'GCAA AAAGCATGCT TACTTCATAA
AGGIIIIT
TTTAATCGCC
TACCCCCACT
GACTGAAGAA
AGACAAAAAG
INFORMATION FOR SEQ ID NO:238: SEQUENCE CHARACTERISTICS: LENGTH: 363 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...363 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:238 GTGGATTCCA TTTTAATTGA TGAAGCGAGA SCTCCTTTAA TCATTTCAGG GCCTGTGGAT AGGCGCATGG AAAATTACAA CAAGGCTGAT GAAGTCGCTA AAAGCATGCA AGTGGAAGTG 120 GATTTCACCA TAGACGAAAA AAACCGCGCG ATTTTAATCA CTGAAGAGGG GATTAAAAAA 180 GCCGAAAATC TCTTTGGCGT GGATAATTTA TACAAAATTG AAAACGCCGC CCTATCGCAC 240 CATTTAGACC AAGCCTTGAA AGCGAATTAC CTCTTTTTTA TTGRTAAAGA TTATATTGTA 300 GCCAATAATG AAGTGGTGAT TGTAGATRRA TTTACCGRCC GTTTGYYTGA AGGGGAGGCG 360 CTT 363 INFORMATION FOR SEQ ID NO:239: SEQUENCE CHARACTERISTICS: LENGTH: 177 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...177 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:239 ATGACGATCA CCACCCTATC TTTTTTATTC ACAACGCCAG AAGTGTTTGT CAATCAGGAT TTCCCATGGC TTTCTGGGGC TGGAAGGCTA GTGGTTAAAG ACTTGGCGTT ATTTGCTGGA 120 S* GGCTTGTTTG TGGCCGGATT TGATCGAAAC GCTATTTGGA GGGTAAAGGG TTTTGCT 177 INFORMATION FOR SEQ-ID NO:240: SEQUENCE CHARACTERISTICS: LENGTH: 426 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .426 (Xi) SEQUENCE DESCRIPTION: SEQ ID NO:240
GTGTTI'TCTG
CAAGTGGCT
TTAGCTAGCG
GGCAATCTCG
AACGTTTTAG
ATCATGCCTT
AAAGCAGAAA
AGTCAT
GCAATAAAAG
TAGGGGCGTT
GCATACAAAG
CTCCAAACGC
CGATCATTAT
TAGTAATCAA
GCATGAGCGC
GGCTATAAAT
GGCTTTATAT
CGTGATTGGT
TAAGGGCGAT
CTTITTGCT
CCTCATCGGS
AGCGGCTAAT
TATCGCACGA
GTGCCTTTGG
TACGGCTATG
CAAGGGATAG
AGCTTGATTT
GGGGCGTTGC
AYTYTTGTGG
TTGTCAGCGC
GCAGAGAAAT
AGGGGGTACG
GAGGCTTTAT
CACTTCTATA
AAAAATGCTT
CGCACACCGA
CTTTGTGATT
ACTGCAGGGT
CTITI'TATT
CTTTGCGATC
TTATl'TAAAA
AGGCACTTCT
AGACRCCCTr 120 180 240 300 360 420 426 a a a *aa.
a a.
a INFORMATION FOR SEQ ID NO:241: SEQUENCE CHARACTERISTICS: LENGTH: 240 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .240 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:241 ATGCTGGTGG GTATCAGTAA CGCTATI'AAT ATCATTGACG GGTTAACGG GCTTGCATCT GGGATTTGCG CGATCGCGCT TITAGTCATT CA'ITATATAG ACCSTAGCAG TTTGTCTTGT TTGCTCGCTT ACATGGTGCT TGGGGTTTAT GGTGTTAAAw TTCCCT1'CAG GAAAGTrFI TI'AGGwcGAT CGGGGGGGCG TA'FITITTGG GTTTGGTGWR CGGRATITCT CTCTTGCATI' INFORMATION FOR SEQ ID NO:242: SEQUENCE CHARACTERISTICS: LENGTH: 225-base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .225 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:242 ATGCTACATA AAAAATATCG TCCTAATGTT GCGGCCATTA AACACATGCG AAGTTIAT CGCTGAGCGC ATAGACATTG CAAGGAGGCA TIGATGAGGG AGAGACCCCT TI'AGAAGCAC GAAATTGGCA CGAATGAAAT AGAGATITTG GCGCAATACC TCATGTCGCC AGACTACCCT AAGGGGCGTG GCAGTTCCCC TCTATAGAGA ATTACTAGAA
CTAGA
INFORMATION FOR SEQ ID NO:243: SEQUENCE CHARACTERISTICS: LENGTH: 354 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .354 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:243 ft...
ft* ft. ft ft ft
GTGATGCTAA
ATGAGTTTAT
TTAAATGATT
AGCAGAAAGG
AAAGAACAAG
AAAAAATI'TG
TGGCAATITT
TCGCCAATAT
TTGTTFFI'GG
CTATGGAAAA
TAGATATI'AG,
ATTTTGTTAT
TACCCCTTAT
GGGGTTGGAG
TATAGAAGTG
TCATCTTATC
AGAArrl'GAG
TTTTAGCAAA
ATTCTITATT
CAAATTTTTT
GGGCII'GATA
GGTCTTTI'G
GATI'TACGCC
GAGAAAACTT
TGAAAATGAT
GCAACAGAGA
GCAATGCGAG
TCCAAGCTCA
AGGCTTTTGG
ATTTTCATAG
GAAAAAGTCT
CATTAAAGAT
AAAAAATCGT
ATTAAATTTT
AAATGATACT
AAGC
120 180 240 300 354 ft.
ft ft INFORMATION FOR SEQ ID NO:244: SEQUENCE CHARACTERISTICS: LENGTH: 627 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE:-DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .627 248 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:244
ATGATCCGTC
CTI'CTTTTA.A
AAAATGGGCG
AITTACATAG
ATTGATGAAA
AGAAACGCTA
TTCAAAGCT'
GGAGATGCGA
T1'CAATGATC AT1'GATAATT
TTCAAAAAAA
TAGCCGCGTT TTTITrTAGCT AAAATGTCTT GCTCAACCCC CTCATATAGA ATATGTTATC AGCATGCCCC TTTAAAAGCG TCCCCGCTTT AAGCATCGCT AAGATTTACG AGCCAAAGAA TAGGGATTGA. GTGCGAAGAA GTCAATTAAA GCAGCATT ACAGGATTGC GATGAG TTT C TAGMA.TGCGC GAACATTTCT GGAGTCTCAA TGGAAAT
CTCGCTTGCG
ACTCGCATAG
CAATCCAAAG
ATCAGTATTG
ATGCTTTTTG
ACATAGGA
TTTGAAGACG
TCTAAGATTA
GCTGTI'TTAA
TTCCCAACCT
CGATTACGCC
AAGCTTTTGA
ATTI'AGAAGT
ATCAGAATAT
CAAAAGGCAA
TTAAAGCGGT
GGI'TTATAT
AACCCCCTAT
CTTTAGCGTT
TTCAGCTTTG
AAAAAGCCGC
GGTTFI'GAAA
TATTGGCGAT
CGCCAGCCFI'
AAGCATGGTG
TGTTTCTAAT
AGAGGGATI'A
TATCAAGAGT
GCCTTTAGAA
GCTCAATCTA
120 180 240 300 360 420 480 540 600 627 INFORMATION FOR SEQ ID NO:245: SEQUENCE CHARACTERISTICS: LENGTH: 225 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 225 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:245 GTGGG-GAG'.T TGAAATTI' AAACGCTATG GGGGTTGATT TAAAGGTI'AA AGAGAGCGCT AATATCATGG TAGGCTTI'GC GAAAAATAAG ACCTTATGCG CGTTATTCAT TTTAGAAGAG CG TTTGAAAG CTAACGCTAA AGXAGTCATT CAGGC TTAC AAAATCAAGG CTTGGAAT1'A GAAA'I'T=IAA GCGGGGATAA TGAAAGCTCG G LTAAGGAGT GCGCG INFORMATION FOR SEQ ID NO:246: SEQUENCE CHARACTERISTICS: LENGTH: 363 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DRA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION l...363 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:246
ATGGAGGCTT
TTTGTG'ITGT
AGGCTTTTTA
GACTTTATGA
ATTAACGCTA
GAAAACGCGA
GCA
TAAACGCT
TGCAAATCTT
AAAGAGAGAA
CTI'TAGGGCT
GCAAAGAAGA
GCGTTAAAA
GAACGCGCAA
AGAGCCTATG
TTTrCAAGCCT
TACCAITAAT
GATATI'ATT
AGAAATTTAT
AGTGATGAGC
ATCCCGCACA
ATAGAAGTAG
GGCAAAAGGC
TTGGCTAAAA
GTGCCTAATA
A.AATTTATG
CGGCATGGGA
ATGAAAGCGC
GCGCGGAATT
AAGAATTAGA
AACTTGTI'AA
CGAGGGTTAT
ATTGAGCGAG
TT1'GATAGAA
GAAAGTCAAT
GAAATATTA
TTITGTTACC
INFORMATION FOR SEQ ID NO:247: SEQUENCE CHARACTERISTICS: LENGTH: 306 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 306 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:247
ATGAAAGAA
AATCCGGGCT
AAAGAACTGA
GATAAAAATA
AT'I'TTGA.AT
CITGCA
GTATTAAATA
'IWGGCGGGCA
TCAAACGCTA
TCTITGAACT
CCAAAGATYG
CTTGCTAGAA
GAAGTI'ITA
CAACCCTAGC
CCAACAAGCG
TAAGCTGGCT
AGCGTGGGGC
GATCTAGTGC
TGTCTITTAG
GGCGTGGATG
ATTGAAGGCT
TAGTGC 1-117.
TAGAAAAGTG
AAGTGGATGG
TGGTGGTTTC
TACAGAATGT
AATGAGCGTG
CTTGAAAG'T
GGGCGTGAAT
AGGGAGITAT
CAGACAACCT
INFORMATION FOR SEQ ID NO:248: SEQUENCE CHARACTERISTICS: LENGTH: 393 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1. 393 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:248
GTGCATGACG
ACCCCTAGGC
ATCATGACTT
GGGATGATGT
GTTAAGGCGC
GGATTTATTA
CGTGAGCCCA
GCGTGCTTGG
TTTTICAAAAG
TAGGGAFI'GT
GGAGGGATGT
TAATCCCTI'A
TTFITGCTTA
ATI'ACGCCAC
GTGGGTAGGC
AGAGATCTAT
GCTTTACTT
GGATCAATAC
TITACAATATT
CAATATCTTT
SCCTATGGCA
TTCACTITGA
TCAGGAAGAC
TCGTCCATGT
GGGAATCTCA
AGAGGCGTTG
ATGACAATCA
RR.A
TTGCGAGCAT
TTGTGGATTT
GGATTGCAGG
CTTACCAATT
GGGGTCTTAT
CGGCAGGCAA
GTATCACATG
CCAATITGG
GATCACGCAA
CATTGACACG
GTAITTTATT
AAAATTAGAG
INFORMATION FOR SEQ ID NO:249: SEQUENCE CHARACTERISTICS: LENGTH: 1323 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1323 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:249 9.
.9 .9 *9 9 9 9 a. .9 .9 *9*S 9* 9 a
ATGATAACGC
CACGAAAACT
TTAAATAACT
GAAACCACAA
AGAAATATTT
AAGGATGAGC
TTAGCCATTA
TTATTGCCTT
GTGAGTTGTA
TGCATCCAAA
CATGAATTAC
CTGTCTI'GCA
GCCCGCATTG
AGCGATTGA
ATCCATGTAT
TTAAAAAACA
TTCATAGGGA
AAGTATFI'GC
GGCATGTATA
AGCAATGGAA
GAAGCGGATA
GGAACAGAAA
GAT
TCTrIAGTTT
ATCAAAACGA
ACTCTGAT'A
TAGAAAATT
GGTATGCTGA
ATI'TTGTGCT
CGGTGGG'11T
TAAGAGAGTI'
AAAGCAAGCA
AAATCAATGC
GCACCCCTAT
AACGC'TI'C
AGCAGCTCGC
TAGATAAGAT
CCTCTCAAA
TGATAGACAA
ATAAITTTAGT
AACCCTACTT
TCATTAAAAA
GAATCTGTFFI
ATGAAGAGCT
AAGCCAATTG
TGGAGCGTTC
AATGCGCCAT
TAGAGCCATA
AGAAAAGGT
AGTGT'ITAAA
ITATAAAGAT
A ITATTGAT
AAGATCTCAA
AAAAGATGAA
GATGAATGAA
CACTAAG3GCC ATCTAT A=
TCAAAAATG
TGccG6.
GCTTACTATT
TACCAGTITG
GAAGATTACC
TTAGCCAAAA
F1'CAGCGATA
TTGCATTCGG
TTATTCCTCT
GTGAAACGCTZ
ATAGGGGATTI
TCTCGGGTT
AAGATACTAA
GATCACTTGA
TATGGGAGCA
C'ITTTAATTG,
GAAGCGGATI'
TACAGCGATG
AAAAGCAAAC
AACCCCAGCC
GCTATGGGAT
GAITGCGTTT
GAAATI'TGA
GAAAAACAAA.
TCGTGTCTTC
?I'ACCACTAT
TCTATAAAAT
GACGCCACCA
TGGTTTTI'AT
TTI'CTTATAG
TTITATFI'GT
TCGCTCAAGG
TGGCTAACGA
TATTITTGCG
GCTCTATGCT
ACATGTTGAT
ATAAAGAAAA
ATGAAGATAA
TTGAATTG'1T
ACAAACAGGT
CTTTAAAAGA
AAGCCCATGG
TGAATTTGAG
TTAATAGTT
GAGAGGTGAA
AAGAGAGAAC
TCAAATCAGT
CAATGAAATT
TGGCTITAGA.
GTTGCACCAC
CCTTITAAAA
GAATTATTTC
TTI'GCAGAGT
GGATAAAAGC
ATTTGACAAT
CTCTATCATG
CAAAGAAGAG
TGAGCAAT1T
ATITTTAATG
AAAAAGCCCT
TGCTATAGCG
GITFI'TGGAT
AGATIITGAA
G'Tr GGGTTA
CTATCAI'AT
TTACGATTTA
GGGAATGAAG
ATGTICAAAC
120 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1323 INFORMATION FOR SEQ ID NO:250: SEQUENCE CHARACTERISTICS: LENGTH: 381 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .381 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:250
GTGCTTCTCC
GCFI'CTTTAG
GCGTTAGGGA
ATTTI'GGATT
CTTATGTGGA
CCTATATTAA
TrCTGGGC.AT
TITTCTCGTAT
TCATTCGTGT
GTTCGTAGC
GGCGATCCAC
AAT1'GCTCCC
TGAAACGCCC
'ITCACCACT'
GGGTATCGCT
CGCGCCAAGA
GATGATF1'TA TTTrGGCGTG
GCATCTACCG
GCTTTTAGTG
TTIGCCCACT
AACAAAAAAC
GGGTTGCCGC
ATrGGGGGCG
AGTAGAAACG
GGGATITATT
CTATITrTTG
AACAGGCCTT
TTGGGAGGAT
F1GCGACTCT
CCGGCACGCT
TGCYTGTGAA
GTCCATCACG
AGGGCTGTTA
CATTGGGCAA
TATAATGCTG
CGCAAGTGTT
TCATGGTTAT
120 180 240 300 360 381 00 0 0 0 ~0 0 0000 0* *000 00 0 0 *00 INFORMATION FOR SEQ ID NO:251: i)SEQUENCE CHARACTERISTICS: LENGTH: 345 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc feature LOCATION 1 .345 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:251
ATGCGCAT'A
GC'ITCTGA
ATAGGGATr
CCAGAAAAAC
TTACAAGACA
AGCAGGCAAA
TCATAAGGTI
TGGGGGGGCT
TI'GTGTTGAT
GAGAAGAATA
AGCAAAAAGA
AACAAGACCT
ACITTCATTT
ITGGTATGCT
C'ITGTTrGTT
CATAGAACGG
AGAGCAAATG
TAAAGAACAA
AAAATGAACG
TTCA.ATGGCG
ITFFI'ATCC
CTTAAAAAAA
CGCCTCTATC
ATGAAAAAAT
CTTI'AAA
AAGGCTCTGA
GCCCTGTGAG
ACCATGAGAG
AAGCCAAAAA
ACTCA
ACTCGCGCTC
GATTGTCGCT
TTCCAAGAC
GAAAATGATC
AGAGCGAGAG
120 180 240 300 345 INFORMATION FOR SEQ ID NO:252: SEQUENCE CHARACTERISTICS: LENGTH: 258 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .258 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:252 GTGCGATCTT GCAAACAGAT TTITGATAAG GGTTI2AAAGC CCTATTATAA ACATTCTGTT TGCTTAAAGC CTrTT 9 TAG GTTTTG'I7.FI CTCAAAA'rrC ATGCTTATCA ACAGCGTTAT 120 AGAGCGTTTG CTCTAACGCT CTTTTCTTGT AAGTIT=rA ACGCITGTAA GATTTTrATT 180 CCCATAA'G ATFITTAAAAT CGTTrATC CCTATTCTAA AACACCAAGC CAAGCTAAA 240 AGAGTCTCTA ATGCCTAT 258 INFORMATION FOR SEQ ID NO:253: SEQUENCE CHARACTERISTICS: LENGTH: 132 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni 9 (ix) FEATURE: NAME/KEY: misc-feature LOCATION .132 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:253 ATGTGTGGA TGGGGTTTAT TGGCTrCAAA ACAAAACTTA CTCAAACAAA GGCATrATT ATATTGATCC CAATCT TTCA GGACAGAGCG GTCAAAGCGG CAACACGCTC AGCACCTATA 120 CAGCTAATIT GT 132 INFORMATION FOR SEQ ID NO:254: see 0{i) SEQUENCE CHARACTERISTICS: LENGTH: 1680 base pairs TYPE: nuclefc acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1 1680 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:254 ATGGGGAATT 'ITAATAGCTA TGGCGA1'TTG GCTATTATCA ATACTCAAGG
CACAGCGACG
T1'CAACGC'Fr CTI'CAAAAGA AGTGGGTACT TATTACGGGT ATAACAACCA
AATCACAGGA
TATGCGCTCA TTGATATTAA TGGCAAGCAc AACGGGCAAG CCGTGAGCGT
TAAAGATGGC
AATCAATACA TTTACACTTC CATTCTTTAT CCTATCAATA ACCCACAAGC CCCCACTTTA CAAAGCGTGG ATAGCATCRA
TCAAGCTGGC
ATCTTTGAAA CTAAAGGAAG CCCTI'rATrC AA.AGATI'rAA CCACGATCGC
TGGAGATATT
AATTTTAAAA ATGACGCCAC TAATAF TT'A CGTTTAGCCA AGCTCTCTGA
CACTTCAACT
GAAGCCCTTA AAAACAAGCG
ATTCGCTGAT
AAATACTCTC AAAGGAATAG
AGTTIAAAAAT
AGTTTCATTA GTGGAGGTAC TGRAACTFrTA ATTAAGGGCG TGATrGTGGG
AGGTTATG-C
ATCACTCAT CAGGCTCTAG
CAATGTCAAT
AGAAGCGAGC TAACCATGAG
CTI'GAATGAG
TCCTATGACC CCCTACTCTC
AATCATCAAT
GACGCTAAA TCAATTATGG CTATGA TTT C CCCCAAGTAG GCITAAGCTA TTATTACATT GATCCTATT ACAACCAATT
CAGAGCCAAT
ATCAA71iTIG CCCTAGAAAG
TCGGCXITAT
GCGGATGTGG GCAGAGACTT ATTCATrAAT GGTAATAACA CCCTAAGCTA
TAGAGATGGT
ACAGGCGGGG AGATAAGAT
GITCAAAACC
TTTGGGCTTG ATTATAAAGA TATTAATATT
GTGTI'TAACC
ATCATGGCCA
TACACGCTGA
GGCAGTAGCC
ATGGTGATGA
GGTTTAGTTG
AATAAAGTGA
AAACAATATA
GGAAATCAAG
GCTCCCTATT
GCTAACACTT
CAGATCAA~CA
ITCGCCCGTT
GCGATCCCTA
AATGTGTGGG
TATGGTATCA
GCFI'ATGGGT
GTGGGCGTr
ACTTGGGGAT
CAGTCTrACA ATGTTrAAAG
GGTTTGTCTG
GCTGACCCTA
TTCAATAAAA
TCTATGGGGG
GGCAGATACA
'TTTTATGTGA
ACCGGAAATA
TCAGTCATTC
ATAATAACCC
TTGATAGCGC
TGGATAATTA
CTGACAACGG
TAGGCTTIAA
AAATCGCTGT
TCGCTCWAT
CGATTAAT'G
ATCTAGAGAG
TAGAAGTCAT
CCTACACGCA
CTGATTTCTT
ACGCTATGGA
CGACAGGAGT
ATGWAGGGTA
ATAGCGGGTT
ATAGCCGAGC
ACAATAAc
GATACCACAC
ATAAAAGCGT
GTTTAAGGGG
ATAAAAAATc
ACTCTTATTA
ATAAAATGGT
ACACTTTTGC
ATGCGGGCAT
ITGGTATGCW
AGTTAGTCAT
TTTGATCCAA
TAAAGCCATr
CCTTAAGCTT'
CTTAACcTAT
GGACTCTCAA
TTCTAATGAT
TCAGGGCGI'r
GCTCAATA
CCACTCCACA
CGCTAACCCT
GCAAATGAGT
AGAACGCTTA
TGTGATTITA
TGGAGGGGCT
TGATAGGTTT
CCATGCAAAC
GT'ITATCAAA
TTTCATCAAC
TTGGACGACT
TATTITTTAA
CATTATGGAT
CGTTCTAACG
TTTTGTGATr
GCGTTTCATC
TAG CATTATC
AGGGGCTAGG
SYATRCTrTT 120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 INFORMATION FOR SEQ ID NO:255: SEQUENCE CHARACTERISTICS: LENGTH: 423 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: taenomic) (iii) HYPOTHETICAL:
ND
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: He.1.:cacrer pylori (ix) FEATURE:- NAME/KEY: misc_ feature LOCATION .423 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:255 0 000 0 ATGGAGTCGA ATCAwTCACT GCGGACAA AAGGCTATAA TATGGCGrc
CGTTACTGCT
GCTITAAACA ACAGAGGCAA TI'GCAATrGA
TGAGGCAAAG
GACAAGAGC.A
AGATCGCCCC
CCCCATGGCA
CGGCTTAGTG
TI'CTACGCTC
TAAAGAAGAG
CGGCATGGGG
CATTGTGGTG
TI'AATATCAT
GGGGkL.TTGA
ACTAACGGCC
GTGACTAATr
ATCAATCAAG
ATTAGAGAGG
GCTCACCTAA
TTGAAAGGAA
TATrGATrGG TC7TTTGGGGA
TGGTCAATCA
GGAGTAGGGT
CGCTAAAGGG
TTTCCAACC
GATCACTTCG
EITATCTTrA
AATITTAAGA
CTT1CATTTCG CCCAATACTG ACATCTTvI'r CCCTATACCC AGAGAGAATG AAGTCATCGC TGAGTI'TTT G AAiG INFORMATION FOR SEQ ID NO:2S6: SEQUENCE CHARACTERISTICS: CA) LENGTH: 153 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc feature LOCATION .153 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:256 GTGAATTTTT ACCTTFICGCC CAAAGA'ITAC CACCACTACC ACGCCCCTTG
CGATTTAGAA
AT'ITTAGAGG CTCGTI'A'FT TGCGGGGAAA TTACTACCAG TCAATAAGCC CTCAITACAC AAAAzACAAA ATCTGTTTGT GGGCAATGA AGG INFORMATION FOR SEQ ID NO:257: SEQUENCE CHARACTERISTICS: LENGTH: 699 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 699 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2S7
ATGGATATT
GATGTTTCI-r
GGTAAAACCA
TAWITAAACG
GGCTAC'FTGC
CTAGCAGGGG
CTTGATGCT
GAAAGAAGGC
GATGAGCCT1'
AGCTGAT
TAAAAGCAGA
TAGAAGTGAA
CCACCTTITA
ATGTGGATTT
CCCAAGAATC
AGAGCACTTI'
TI'AATATCCA
GCGTAGAAAT
TI'GCGGGCGT
GATTAAACAT
GCATTTAAAC
AAGCGGCGAA
CATGATATGC
AGCTAAATAC
CAGTATTT
TAAAAACTCT
AGCCATAAGA
CGCTAGGGCT
GGATCCGT
TGGCGTGTTG
AAACAGAr1'A
GTGGTGGGGC
GGGCTTTTAG
CCC'TTACACA
AAAGAATTGA
AAAGAGAGCG
GAGCGCAAGG
TrAATGAAAA
GCGGTGAT
AITAcTGATc
AAAAA.ACCAA
TI'AGGGCC
AGCCTAGTGG
AGCGTTCTAA
GCGTGGAAGA
AAGAAAAAAT
GCATGAGCTT
ACCCTAAATT
ACATTCAAAG
ACAATGTGCG
AATCGTTT1CA
TAATGGGGCG
GGGGAGCGT
CIGGCATA
GAATTTGGCC
GGAAAGCTTG
GAGTGGGGGA
CGTGCTGTrA
AATCATITGAA
AGAGACcTTG 120 180 240 300 360 420 480 540 600 AGCGTGTGCC ATAGGGCGTA TGTGATCAAA AGCGGCACGC TTTTAGCGGC GGGAACGCTA ATGAAA TTT A TGAAAACGCT TTGGTGCGTA AGTATTATT INFORMATION FOR SEQ ID NO:258: SEQUENCE CHARACTERISTICS: LENGTH: 474 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .474 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:258
ATGAAAGAAA
AAGGA'FITTA
AGCGGTAAAA
GTTAAAATCT
ATCGCTCAGG
CTTAATI'AC
AAAATGGGGT
GCCAAAGAGT
TCGTTACAAT
ATTTAAGCAT
GCACGCTTTT
TTAATGAGAC
GCAATTCCTT
AAGGCATAAA
TAGACGAGAG
GGGCATI'ATT
AGAGAATGTG
TCAAGAAGGG
AGGCTTGATT
CCTTTCAAAC
AITCCCTCAT
CAAACAAGCC
CCTTATGGAT
AGGGGGATTA
TCTTTTAACT
GATFTTTTTAT
TTAGGGCTTT
AkACGCTTTTT
TTAAACGCCT
GCTCAAAAAG
AAATTCCCTA
TCCACAGGCC
ACCACAATCG
GCGTFITTAGG
TAAAACCCAG
TACGCCAAAA
TACAAAACAT
AAGCCAAAGC
ATGAATTGAG
AGAACTCAIT
CGCTATT'ITT
GGAGAGCGGG
TCTGGGGAGC
A.ATAGGCTAT
GACT?'TI'TGC
CTTAGCGTTA
TGGGGGGCAA
TTAT
INFORMATION FOR SEQ ID NO:259: SEQUENCE CHARACTERISTICS: LENGTH: 573 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION 573 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:259 0 06 *0 a ATGA~TTcc
GCTI'CCAGCT
AGTCTTITTG
CCTAACGCTC
GACATGACCT
CCGAGCGCTT
TGAGITITI'A
TGTCTCATTA
CTAAACTCAT
TAGGCACGCT
TCAAAACGCC
TACGATTG
CTI'GCAAGCG
TGGCGCGTT
TGAAGAGGTG
'T=AGGGT
TCITI'ATCGC
CACAGCOGTG
AAGGATTITT'
TCTATI'GTGG
TAAGCGAATT
CTATITTGTT
AAATGGAAGC
TAGAAAATFI'
TGGCGI'TGGT
GTTACTAC
GTrCGTGTTC
CTI'GATTC
TAAA.AAAACA
GCTITI''TGT
GAAAACTACC
T1'IAAGGGTA
GCTITGCCTT
TCAAGCITGT
ACCATTCCCA
GCTCCATCGC
AAGAAATCrI'
TGGTGGTGTT
TGCATGTIT
CGAATAAGGT
GTCAAAAATT
TTl'ATITIGG
?IIIGATATT
AAGATGGATA
GTT1'AAACTA
TTTGACGCAA
GGGTITGGCA
AAGATCCAAG
GGCACTTACG
YYA
AGCCCAGAGA
CGACTTTAGT
TGTTI'TTGA
CGTT1TTTT
TTATGCGCAT
GTITTTATTC
AGATAXAGAT
GATCVITFFI'
INFORMATION FOR SEQ ID NO:260: SEQUENCE CHARACTERISTICS: LENGTH: 729 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 729 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:260 0 0 0000
S.
0 0*S* S @5 0
S.
0**9 0 0@ 05 0 0 0
SOS.
Se @5 S S 55 0
ATGGTTGA
AAAAAAAATC
AGGGAAGTCA
CTI'CAAATCA
AFFI'TAAGCG
AAACAATTAG
GTAGAAAAAT
GACACGCT'G
ACCTITAATC
GGGAAATTGG
ACTAAACTGA
GAAGAAATAT
AAAGGGCGA
TGATFFI' CAC AAGCATCTI'G
GTTATGG
0
TT
TTGAATGGCG
ATAAAATCGC
TGATAGACGC
AALAAA.ATrAG
TAGAGCITAA
ATITTACCI'
TTIGTGATTGA
GGAGTTITTGA
TCATTGAAAC
TGACCGGCTG
TCCTAGAATC
AGAAAAAAAG
TAACGATITA
TGATATAGAG
CGCTTCTCTT
CTATGCGCTA
TATTGTTGGG
TATTGATAGA
ATCTAGAGAG
GCCTAAAGAA
TATITTAAT
AAGATAGCGT
TITGATGTTG
AAAGCGTCAA
AAGCGTGATA
CGTGGTITA
TCTAAAGACA
ATAGACAATA
GATTCTTITGA
CCCATGAGCG
CAAGCGTTAG
GCG'ITAAAAA
GGCGCTTACC
TAAAAGTI'
CAGACATAGA
AACAAAGCTA
AGATAGTGGA
TCCCGCCTAA
TCGTAATAAC
TCCAACATAA
GCGI'CAGTC
.AGCAGITTCT
AGTGGGTGCG
ATGCGGAATT
GCCTI'CAAAA
ATCAGAGCGA
ACAAGAAGAG
TAAACAAAAC
TAAAAGAACG
AGATTTGTTA
GATAAAGCAA
CACGCTTGAT
GCITIATGTT
CAACCWTATT
ATTATCGCAA
ATCACAAAT1'
CGATCTTAAG
120 180 240 300 360 420 480 540 600 660 720 729
SO
0 0 @54. 8 INFORMATION FOR SEQ ID NO:261: SEQUENCE CHARACTERISTICS: LENGTH: 708 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 708 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:26.
GTGAGTGAGG
GATTCTTTGA
AATAACGATA
CATGGCTATA
ATCCCTITAA
GCGGCTAATC
GCTGACACTT
AACCCTGATG
GACAATTTGA
TICTTACTGC
ATCAGTT1'CT
ATTGCAATCG
TCGCGAGCGT
TCCGTTATAA
CCGGTGGGGG
TCCAATCTT
AAATCAAAGA
TCAACGGCGA
ATAAGGTGCT
TGAAAATCAC
TTCACACGCT
ATT TCAGGAG
TGCTCATGSG
CTATAGGGC
GGGGGGCTTI'
CTTGAG'ITTA
CGTI'ATTTTA
AAACGATTA
TATAGCGAGC
TAAGGAAGTG
TAAAGCCATI'
CAGCGTGTAT
CATAGAAGAA
CGCTTTAGTG
TTA'FTTCRAT
GATGGTGAAT
GTGAAGGATT
GAACAAGTCG
GAAAACGGGT
GAAGAAATTG
GTTAGGCTAG
GTGGGCGGGA'
AAAGAAAAAA
GACAGGAGCG
AGCGTCATTG
GTGATTATCA
ATTGAAGCGA
GCGGCGATTG
ATGAAGTAAC
CTAACGCGAT
TTGAAAAAAT
TGGTTA)AA
CGCCCAAACC
TTGTTATGGT
TCGCCACCTT
AATTIGATTGA
TGCTAGTCAT
CTCTGCCI'T
GCATCATGAG
TGATGGTG,
GCTTCAAAAC
TAAAAAITCC
TATAAGATCG
AGAAGGGGCT
GCGCAGAGGG
GCGCTATCAC
ACAAGCGAGT
AAAAGGCATT
TA'ITGCGATT
AAGYGTGTGC
TTTGGGGGGC
120 180 240 300 360 420 480 540 600 660 708 INFORMATION FOR SEQ ID NO:262: SEQUENCE CHARACTERISTICS: LENGTH: 525 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc feature LOCATION .525 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:262
GTGGAAACTT
GTCATTAACG
GAAGTGTGCG
ACCCAATCAG
AAATACGCCA
TTAGAAAA4AG
TTAGAAAATT
AATTCGTATT
GAAATCGTGT
'FrCTTAGAAT
CTACTGAGGG
AAAAAWTAGA
AACAGGCTAA
ATGAGAAAAA
TGGAAAAGCT
TGAGCGCTGA
TTATGGATGC
GTAAAAAAAC
TTTI'GAAAAA
GGGGGCTAGG
CAAATCCAAG
AAA'ITTAAAG
AACGCAAGTT
TCATGAAAAA
AATI'GATAAC
GATACAATCT
GAGTAATGAA
GATATTI'TTA
ATTWAAAGGGA
CCAAAGCCTC
ATCGCCAAGA
GAAGAAGCGT
AACAAATI'AG
GTI'AAAGAC
TACA'TI'I'CC
GACGGGATTA
ACACGCCCTA
CTAAAGAAAT
CTATCAATCT
AAAAATGCGA
TTTTAAAGGT
AAGAGTTGGA
TI.M. GATGA ACCAGGAATr
AGGGC
TAAATTAGAA
GCCCTTITAAA
TA'FrTATCCC
AGAGATCATC
GGCAGAGTTT
TFI'TGAAGAA
CAAACGATI'C
GCATATCGCT
INFORMATION FOR SEQ ID NO:263: SEQUENCE CHARACTERISTICS: LENGTH: 678 base pairs TYPE: nucleic acid STRANUEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (iX) FEATURE: NAME/KEY: misc feature LOCATION .678 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:263
ATGAAAACGC
GTITATGTTA
CCTAGAAGTG
TATATTTTGG
GCGTTTGGCA
GAITTGTATG
CAAAAAGTGG
GTGGGACTTT
AAATACGCAA
GCGCAGYTTG
TTTCATTTTA
CTCATAAGAT
CTTGCAACGC
ATTITAGCGGT
CCATAGAAGR
GCGA.AA'FITr
TTGGTGGGGG
TGGAATATAC
A 11TT1GAAAC
TGGGCTI=AA
TTGAAACTT
ATTTTTTrGA
GAAGTTTGCA
YAACGCTT
CTATTFTCTC
GTTTCTTT
AAAGCCCTTA
AAGCCTTTrG
GACGATGAAT
CGGCACCGCT
GATI'AAAAAG
TAACACCTAT
CAGCGATTTA
AAGAGAGGAC
TGAAATGGAY
AAAACGCCAC
TTATTGCTAG
GTCGTGGCGA
TTAGAAAAAC
ATCCATCCGG
TGGGTGAACA
CGTTATGAGA
TCTTTAGCGA
GCCTTTCATA
GCTTTTAAGO
ATTAATTTGC
CCAAAAACAA
CGAGCGCT
CAAAACCTAG
ACCATATCCC
CATTGATTAG
CGCTCAAAAA
AGGAATTrAA
TT'TCTAAAGA
GCCCGAATTT
GCTTAATCAA
GTTATAAAAG
AAA.AAGAAGA
ATGGCTCATT
CAGCGAGCAG
TATCAAGCGA
GGGCGATTI
CCCTrGACT TCTTTT1"GTGG
AGACGCTCAA
TGATTTTGGA
AGCTTATCGC
TITTmGAATCC a a a a. ILTFOP14ATION FOR SEQ ID NO:264: SEQUENCE CHARACTERISTICS: LENGTH: 237 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
liv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .237 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:264 GTGATGGTFI' ATAAACTCCC CAAACACCAG CAAAATAAGG TCATGATITT TTAGCGATGA TCACTCGTAT AGGGCTI'TA GGGAGCTTGT 1"11 CATCAG AAGCCTrrAT TCGCTATAGC GGGCATGAGC TFTTCATGGC GTGATGTCGT GGGGGGGCGT TITIGGCTIT TAAGGCGTTA GTGGAATTAA
AAAGAGCAG'A
a a a
AGGCTTGGGC
CCATTTGCAA
GCTGCTTTTA
TCTATCC
INFORMATION FOR SEQ ID NO:265: SEQUENCE CHARACTERISTICS: LENGTH: 630 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (i-ii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .630 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:265
ATGTTTGTGG
GCGCAATCCT
GCCTTGTGTT
TATTTCGCTA
GGATTTTACG
CAAACCCCTA
CTCAATCCTC
AACCTAGTGC
TTATTGTTAT
'TrTATGGGCG
AGGGATITIM
TTTTTATAGA
TGTTTATTGT
TTATGTGCGA
AAAACCTTTA
C11TTTTTGGC
AAAAATTATC
AAGTGTXTT
AAAAATTCGT
GCACCATGTC
TGAATCTCTT
TAGCGTTATT
AGGTTTTGGT
GGAAAGGGGG
TATTGTCTTA
TTTGAGCTTG
TTTAAAAACC
CTTAAAAAAG
GGAAATGGTG
CTTTCTAGCT
CTTACGCTAT
TGTAACCGCT
GAGCAAAACC
TTAGCGATI'
ATGGCTAGGA
ATGAGCATGG
TT1'TTGAATT
CTTTTTCAAA
ACCTTATTAT
TTTI'TAAT'G
GGCACTTTAT
GGCTCTAAAC
ATCATGGGAA
CTTTGTGCGC
ATTATGTGTT
GCGTGTI'GG
TATTTGGGGC
CCTTITAAAAA
TCACTTTAGG
GCGCGAGCGC
CGGCTGCCTT
TTTTGAACAA
CGCTCAGCGT
GGCGGTGGGG
TTTGATTTGC
CGTGGGGGCT
AGTT=rACC
AAAGCAAGTC
CGTTACCTITA
TATGTCTT7Fr
TTCTTGGCTT
CCAAAAAATC
TACTTTATTC
INFORMATION FOR SEQ ID NO:266: SEQUENCE CHARACTERISTICS: LENGTH: 888 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 888 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:266 **0 00
GTGAAGCCAA
AAAATGATTG
GCTAAAAAAG
AAGAGTGTCA
GCTI'ACCCTC
ATGGAATrI'T
GAAAAAGACG
GTGCAATTGG
AGAAGGCTTT
AAGGAAATAG
AAATI'AGCCG
TAAAGCGC
GAAAAGATCA,
GAAAAAAACA
ACAAGTTTG
AGAGCATGAA
AAATAAGCGA
AGCCAGAGAG
GGCAAA'ITCA
AAT'I=~AAG
TAT1'GCCTAA
GGCAGTTITT
AAGTGATCTT
TAGATAAAAA
AAGA.AGCCCT
G TTTAGAGA iTi"TI rAAG
TGCGITI'GG
ATCAATCCGC
AGTGSTTIAAA
AGAGAAGCTA
ATGGT2GCAA 'I I- ICTCAAG
AGCGCAATTC
CTGTGGTTTA
AGTTTATCCT
GAGIAGAAATG
AAITGATGCG
CAATGACTTT
AAAGCATTTG
TTFI GTGCAT
CGGGGTGGAT
CTCTAAAAAT
AGAAGATTTG
ATACCTTAAT
AGAGGCGCTA
AAACTAGACG
CCGATCATTT
ACAGACGCGC
TTGCAAGTTA
TTCCCCCCTA
CTCATGCGCT
TTGAGCTTGG
ATTIACCAGC
CATGAATATT
TATAATGAAA
GCTFI'GAGTA
GGGGT=TA
AAACGCTATG
GTAGAAATCA
TGGTGAATAT
ATGCCrI'AGA
CACCAATAGA
CGAAGTTCAA
GGGGCAAA)JA
AA.AGCTTGTA
TACTCTCCAG
GGGGCA7 MI
AAAGGATIT
TAAAGGTI'AA
ACGCCAAAGA
AAGACGCGCT
GCTTTGTCAA
CGGAGTTTTT
TCAGCGAT
CTIAAGGATA
TAAAGTTGTT
GGACTACCAA
TGAAGAGGGT
TGGTGCTAAC
TATAGAGCAT
CGCGCCTTI'A
CAATCTGGCC
GACCGAAAGC
TTTGCAAGAA
CTCCTTGCCT
TTATTATCTA
TFI'GGAGAGC
TAAAGACAGG
INFORMATION FOR SEQ ID NO:267: SEQUENCE CHARACTERISTICS: LENGTH: 282 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc_feature LOCATION .282 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:267 GTGCT7TATAA
AAGCAAGAAT
GTGYTAAICGA
AGCGTTGAAG
GCCAAACTTT
GCGTGATGAT
TAGTCGTGGA
GCGGGCTAGA
ATCATTACAC
TAAGGCATGT
AGGCCAAAAT
TTI'CA'ITGTC
TTATAAAAGC
GFTTTAAGC
CAAGTCTTAG
CCAAGCGCTG
GGAGCGGGGG
GCGGTGTTGA
GGTGTGAAA.A
GCTTTATAGG
AAATCAACAT
TG'rTTGTGGG
AAAACGCTTT
AC
GACTAATTTC
AGGCRRTCAA
TGAAGTTTCA
TTTAAGCGAA
a INFORMATION FOR SEQ ID N3:268: SEQUENCE CHARACTERISTICS: LENGTH: 249 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Heizz:bacter pyloni (ix) FEATURE: NAME/KEY: mze.~ture LOCATION Z9 (xi) SEQUENCE DESCR:P7::*: SE IDN,6 ATGGAAGCGC AAMTACGATT .C-C;Z GAGGGCAAG GCGTGTTGTT ATTAGCTG AGGCTAAGAT C'..--TATGGCA CTA.AGACTTC TCGCAAGTGC GTGGAGGTCC CAAA ATATT1'TGT TAGATAAAGA TTCCCTI'ATG CTAAAGAGGG CGAGA=AT. TTCATGC'FrT CAGTCGCTCA AACCAGTTr
AGCGGGAGAG
CACCTACACT
TGAAATTAIT
AATCAGCTAC
INFORMATION FOR SEQ ID NO:269: Mi SEQUENCE CHARACTERISTICS: LENGTH: 609 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1 609 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:269
ATGCAAGCTT
GCTGTCATTG
CCTGATGACG
GCTATTGATG
GGTGAAATCG
AAAATGGACG
GCAAGGACTG
AATGCGGTCG
AAAGTGTATT
ACTAAAGAAG
GGGTGGATAA
AAATTGATGT
TCGCTACTTT
AAGTGTTTAT
TTAAAAACGC
AACAAGAGCT
AAGTACCAGG
TTI'TTICTAC
TGGGCAGTGC
AATACATGAA
GCCGGTATTG
GGCAGAAATC
GAGCGAAGTT
TGGCTCTTGC
CCCTCCCAGT
TATTAATGAG
CTGTAGCTTG
TTCCACACGG
GGAGCTTGGG
TTTAGTGAGT
TTAGAGCCAG
ACGGAGCCTA
TTAGCGGATA
ATGACGAATA
CAAGCACGCC
GGCTATTATG
TGCATGGGCA
AATT1'TGATA
GCGGCGTGCG
GAAAAGCTAG
ATAGTAACGC
TTTTG0CATG
CGACCGGCAA
TTGGGC-ATTT
TTIGGGTAGT
CGATITTTGG
ATCAAGCGAG
ATCGTATGGG
CTTTACTAGG
AGAGCCAAAA
C CAATACGC C C CCTAATGAC A- AGACCCCAC CAGAGC-rT
GCCACCCAGT
GGCTGCCGGG
GGTTAGGGAT
TAGAGGOGCT
GAGGATCCCC
AGACAAGATC
120 180 240 300 360 420 480 540 600 609
TATCGCTMC
INFORMATION FOR SEQ ID NO:270: SEQUENCE CHARACTERISTICS: LENGTH: 660 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .660 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:270
GTGGGCAATG
'FIAGATTGCG
GAAAAAGAGA
ACTTTTAGCG
TACCAGCCTA
CTCAATCACT
AAAAGCATGT
CTGATTCGTT
GAAGCATI'TG
CCCACTATAG
GTI'TCATTGC
CCGGGGTGGC
CTI'ATATCAA
TTGACACCTC
ACTCGCTTT
AAAAAGTCTA
CTCAAGTGAA
TTAGCCCTAG
TTAAAGAGGA
AATGGGTGGA
GCATTTIAFI'
ATCTTAAAGA
TTIAGCGGGT
AGGGTTTAAA
ATCTTITAATC
TTIGCTCTCT
TAATTTAAGC
ATTGAAACAA
AAGTAATCAT
T1TI'ITCACG
TAGCTIGAGT
TGAAGGGAGT
AAATGAGCTG
TTGATGAGCG
AAGCACGCTC
AGCGTAGAGG
AAAGAAAGGA
TATGGGGCGA
ATCAACAAAC
GCTAAGGATFT
CATITAAACA
GGATITTGCC
GTCGCCCATA
ACGCTrAT
ATGAAAT'TA
AAAAITCCTA
GTAATGTTIGA
'FIGAAGAAGC
AAATCAAGCA
AAGACGCTAT
TAAAAAATTT
CGCCTTGTAA
AAACAGCCAG
TCTTACAAAG
CA&ATI'CTCT
TTIGTGCGCT
TTATGGAGAT
AGGTTATGAA
CCTICAI1TAT.
CGCCGTTAGC
CGTTCGCATT
ACAAAAAAAT
AACCAAGCAA
CGCTAAAACC
CGTTCTAATC
CAAAACGCCT
120 180 240 300 360 420 480 540 600 660 INFORMATION FOR SEQ ID NO:271: SEQUENCE CHARACTERISTICS: LENGTH: 744 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .744 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:271 *5
S
S. S
S
*5 S S
ATGCAAAAAA
GTTGGTTTAG
CCCCCTATCC
ATGGGAAAAA
GAGGAATGGC
AAGGCTTCTA
AGAATCCATG
AAAGCCCATG
AAAAGCGAGA
GGGTATTACT
CTCAAAACTT
CCTTATAAA
AATAAGCCTG
GTATATTCAA
ACGATAAAAA
AGTTAAGGCT
GCACGCAGTA
TAGGAGTCGC
TTGAAAACAG
ATTTATATGA
AGCATGAAAT
ATAAAAAGGG
TGC.AAATTGG
TCCCTCACCA
CCAAAGAAGA
CGTITGGTAGA
AATAACTCTG
AGCAGCTCCT1
CGATCAAGCC
TGAGTTCCCT
CCATGAAGAA
CCCGATTTAT
TTT1'TATATA
GGCCCTCAAC
CF1'AACAAAA
GGCTTTTA
AATGGAGGAA
AGCCCTAAAA
GAAG
TTGTTGGT
AAAAGCGTTC
TATGAAGACC
AAAATTAAAG
TGTGTGGCGT
AAGAATTGCT
GAGGGCAAAA
AAATCCCAAC
CCTAGCTTGA
AATTCGCCCA
AAAGACTCCC
CAGCFI'GAAA
TCCTCTT-rTT
AAAATACCCC
TTATCAAAAT
AAATCCTAGA
TAGTCATGTT
ATGAAGCTTA
AAGTGAAAAG
CCTTAAAAAA
AAGACGCAAA
GTAAGGATTT
TCACCXTA
ATGCGGCTAA
AAGGAATGCT
TAAAAATTTA
GTTAGACAAT
ACAAAGCGA.A
AATAAGCCCT
TGTGAAACAA
AAAAATCAAG
GGAACCGCCT
GATCCCTAAA
TTTGCAAACG
TTIGATTGGC
AAGC'TrAAA INFORMATION FOR SEQ ID NO:272: SEQUENCE CHARACTERISTICS: LENGTH: 450 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .450 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:272 ATGCAAGAAA TCTTAATCCC TITAAAALGAA AAAAGCTATA AAGTGTTTT CCTGAAATAA AATTGAAACA AAAAGCGCTC ATCATTAGCG ATAGCATCGT CATTTGCCCT ATTTGTrAGA GCGCTI'GAAC GCCTI'AGAAG TC!AGAGTGTG TCCGGGGAAA AATACAAAAA TFFI'CAI'ICA TTAGAGCGGA TTTTAAACAA
GGGGGAACTG
GGCCGGGTI'G
CGTGATAGAG
CGCCTITGAA
ATGCAATTAA ACCGCCATTC TTTAATGATA GCCCTTGGTG GTGGGGFTG CGAGCAGTAT TTA TTT CAGG GGGATTGATT TTTACTCGCT CAAGTGGATG CGAGCGTGGG GGGGAAAACA CAAGAACCTA ATCGGATCGT TCCACCAGCC GGGGAGTGAT AAGCGATATG TTATTAATAT TCCCTACGAC GGGATCAACA CGCCTTATGG INFORMATION FOR SEQ ID NO:273: SEQUENCE CHARACTERISTICS: LENGTH: 561 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc feature LOCATION .561 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:273
ATGCGAATAC
CTGATTTCG
AATATAGAA.A
ATCAACAGAG
GATAAAAAAG
TI'ATGCTACC
CCCCITTI'AG
CTCACTCAAT
GGGCGTTTGG
GACGGCATGC_
TTCATFIATGG
CTCTTAAAAT
AITACAGGGA
ATGAAACAAA
CGCATTTGAA
AACACGATTT
GGCGTI'ACAA
TGCC171TAGA
AAAITGTACA
AACAAGTIrT
AGGTGAGCTC
TCTCACCAAT
CGCTAAAAAC
CGCCCTTT
TGTTCAAGCC
AAGAGATCCC
CCTTTATAAT
AACGATCGC-A
TTCTAAACCT
T
CCATGCGATT
ATCACAAGCG
AGCTTTTITA
AACCCCATTA
TTTTCGCTCA
AATCTI'AAAG
ATTTTAGCGG
CCGTTATTGG
TTAGTGGTCG
GTCCAAAACG
ATCATTTAGA
AAGATGAGGG
ACGCGCGCAC
ACCCTTCCAT
AAACCGCCCT
GCGTTTAGG
AAAACTTTTA
TGGATTTGC
CATCGCTGGG
TTTCCATCAA
CTTAAAAGTC
TTACGCACTG
TAGCGCGTCT
GATCCATTCC
GG'ITAAATTG
TGGGGTTAAG
CCACACAACA
a a a INFORMATION FOR SEQ ID N0:274: SEQUENCE CHARACTE=:ZT:CS: LENGTH: 594 b~ase pairs TYPE: nucleic7 acid STRANDEDNES:_ =c:.ble TOPOLOGY: r~a (ii) MOLECULE TYPE: C:A ic (iii) HYPOTHETICAL: (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .594 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:274 GTGAGCATTA AAGAAGAGAG CCAAACCTTA GCCGATATTA CITrCCAAAA TTA'TrCAGG
ATGTTITCTA
GAAATCTACA
TTGAACGATC
AAAGAATTAC
GAAACCTI'GC
CAACACACTA
GCGACCAACA
GGGGGGCTGT
AGGGGGCGAA
AACTTI'CAGG
ATTAGAAGT
TGATCTATAA
ACGATAAGGG
ACGCTTTACT
AAGAAGCTGA
TGGCAGGCAG
ATATCATTGG
GCGGGCGTCA
CATGACAGGC
GGTGTCCATC
GAGTGAAAAA
TCAGCCCGTT
CAAAAAAGAG
AATCATCAAA
GGGCGTTGAT
CACTGAAAGG
AGGCGATCCG
ACGGCTCAAA
CCTACTAATC
GAAAAAITTG
TTAGTCGGCA
CGCATCCCTC
GACGCCGGGC
ATTAAGCTCA
CATGAGAGCC
GGAGTGAGTC
CCGAAGCCAC
TAGCGATCAA
ACGCTGTGAT
CGGCTAGCAT
ACACCGTTTT
TTAAAGGGGC
CTGATGAAGT
GTAGGATTGA
AGTI'TATTT
AGAATTTTTA
GCGAAAAGAT
CCTAAATT
TGAAAAGAGT
AAACGCCAAG
GGTTACGATr
TAAAGAACTT
CAATCAATrA
GAGC
INFORMATION FOR SEQ ID NO:27S: SEQUENCE CHARACTERISTICS: LENGTH: 624 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc feature LOCATION 1 .624 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:275
GTGGTGGCTG
GCTGTCGTGG
ATI'AATTCTA
AATAACATGA
,1F1ITGCGCTY
CSTITGGTCT
TATTATGAGG
AGCCACCATG
CACGTCACCG
CATGTCAAAG
AWI'GAAAAAA
ATGAGGTGAG
TTIAAAAGCAT
TGTAGGCTC
TITGTCGCGCA
TGGCTAAACT
CAATTCCT
GTGCGGGTAA
CGAGCGTGCA
ATTCAAAATA
AAAATATTGA
TTCAAAAAGG
AAAGCTCGCT
GCAACAAGAA
TATTAAGGGT
AGCCGCAAAA
CGATCATGTG
GACATTACCA
AGAAAACTTT
TGCTGAAGCT
CCTAGAACAT
TAAGATGTT
CGAA
GAAAAAACCC
GCGAACGATA
GATGTGGAAG
TACACCATCT
GTCTI'rAAAA
GCCCATAAGA
GCTAACACTT
AATGATGG
AA.AGTGCAT'
TATGAAAAAC
AAAAAGCCAC
TTCAAACCAA
AGCT1'AAATC
ACAATATCAA
ACAATCTTTA
GTTSCCGTTT
CAGGCTATAG
TI'AAAGCCGT
TAATGGAAGA
AAGATGAACT
TAAAGAAATC
CACCCACGAT
CACCGTAAAA
TAACCGGGTG
TGGCATGGTG
AGGCAAATGG
AGCTTTAGAA
TCAAGAAGAT
TAGCGCTAAG
CAATAAAATC
INFORMATION FOR SEQ ID NO:276: SEQUENCE CHARACTERISTICS: LENGTH: 603 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .603 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:276
ATGAATACAT
TI'GTTTGTCG
AGCGC=rAG AATI TGAGCC
CCACTCTATC
AACCCAAGAG
CCCTTI'AAAG
CTAGAAACCT
TTAGATGATT
AGCGATT TAT
RTT
CAAAAAAAT'
TAGGGGTGAG
AGCCGAT'CA
ATTTAGTAAG
ACGAATTAGC
AGCTTTTAAG
ACTGCGCTGT
GTAAAACCCC
CTTTAAATT
CACTGCGTCG
AGGTAACCCC
CATGGGCGGG
TT-rTAAGTTT
GAATAAGCCT
CACCCAATAC
GCCTAATACC
CATGGCGTI'
CACTGATTGG
ACTCAATFI'A
TAAAGAACTI
TTGCIT
TGGGCCACTT
GCGCGAAAAC
TTAAACACCA
CCCTTGTTGT
TTAAACCACC
AGAAACCATT
CAAAAACCCA
AATGGAATAT
TGGCT'ITCTA
TGCATGATAA
CTAAAATCTA
TCTCTIAAG
CTGATGGCGG
TGAkATTGA
AGCTCCAACC
CTITTAAAGA
TTTCTACAAA
TGTATTTGAT
AATTAGAAAA
TAAAATTFITG
TCAATITGAA
CCCTTTA
GTTTATGCTA
CCAACAAAAT
AAGC FIAACC
TAGCCTCATG
TCTTAAAAAC
CCACAACCCT
CCYYCAACTC
120 180 240 300 360 420 480 540 600 603 INFORMATION FOR SEQ ID NO:277: SEQUENCE CHARACTERISTICS: LENGTH: 381 base pairs iB) TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .381 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:27 7
ATGAGTATTC
G7"'TTTCTC
CGAGTGGG'T
GAAGAACGI'
CGTATTGACG
GTTGAGTACT
YGCWGGTGGT
AACATTTCCG
ACCCAGAAAC
ACATCGAACT
TICCAATGAT
CCGGGCAAGA
CACCAGTCAC
GCCATAACCA
TGTCGCCCTT
GCTGGTGAAA
GGATCTCAAC
GAGCACTITI'
GCAACTCGGT
AGAAAAGCAT
AITCCCTTTT
GTAAAAGATG
AGCGGTAAGA
AAAGTrTCTGC
CGCCGCATAC
C'ITACGGATG
TTGCGGCATT
CTGAAGATCA
TCCTTGAGAG
TATGTGGCGC
ACTATTCTCA
GCATGACAGT
TTGCCTTCCT
GTTGGGTGCA.
TTCGCCCC
GGTAWTATCC
GAATGACTTG
AAGAGAAFI'A
120 180 240 300 360 381 INFORMATION FOR SEQ ID NO:278: Wi SEQUENCE CHARACTfERISTICS: LENGTH: 237 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO 4iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylorn (ix) FEATURE: NAME/KEY: misc-feature LOCATION .237 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:278 GTGAACGTGC GCGTGCCITTT TAGCTATCAA GTGAGCGCGA CCTTTCAAAA CTCACGCCTT TCTAGTTTGC TAGAAACTrT AAAAAAGAGT TTITTAGAAA AGCCCTTAAT TGAGAGCAGC 120 GCGAATAAAA TCGCGGATAT TITICTAAA GCGGTGTTGT TITTAGCCTT TGTGAGCTTT 180 TTATTGTGGC AATTTGGTIT GGGGGGTAAT TTTGAAAAAS GCTTTAATGG TGTGTAT 237 INFORMATION FOR SEQ ID NO:279: SEQUENCE CHARACTERISTICS: LENGTH: 147 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE:
NO
ORIGINAL
SOURCE:
ORGANISM: H-elicobacter pyloni fix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .147 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:279 ATGCTAATGG TTAATGGCTA TCAAATCACG ATGCATAAGG GTTATAAGGT AGGGTTTTT ACAAGCGGTT ACAACCCTGA 'TrTCGCTCAA ACCATTCAAA. ATAGAAGCTA TTTGATGAGC 120 TCTTATGAGT TATCGIrrI'T AAGAAAT 147 INFORMATION FOR SEQ ID NO:280: SEQUENCE CHARACTERISTICS: LENGTH: 1236 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NME/KEY: misc -feature LOCATION .1236 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:280
ATGGTGCAAT
TTAATTTATA
TTAAGGATTA
CCTAATITr
AACCAA'ITAG
AGGGAAAATA
AAAACCCCGC
AAGCATGTGG
AATI'TAAGCA
TATGGCCCTA
AGCGCTAAAA
TTGTATGATG
CAGATGCTAA
AGGAACAGGC
GTTACTACGC
AAACTACACA
TGCAAGAAAG
AACACGCAGA
GGTGAACCGA
GCAAAGGAI'
GACATCCAGC
TTCAAAACAC
ATGCAAAATT
AAATGCTCAC
AAAAGGATAT
GGCITT1'AAT
TCTCCAAAGC
CTAAACCGCA
TCATGATAAG
TCGC'FrTAGC
ATATCCCTAG
AACTCATTCC
AGGGGCAGAG
GCGATATTAT
GATGCGCAGC
CTCAAATCGT
TTCCTATTGC
AGAGCGAGAT
TITTTAGCCAA
TTGTGATTTC
TGAGTGCTTT
CCACACAAAC
GCTTATAAAA TTCCATGCCC AAACAAAACA TGCTATAAAG CCAAGAAGAT GTCTTAAACG TGTCAGCTrT GGTITGTTA AGAAATCCCC TCAAGCTCTG GATGCAAGAA AAAGGCGTGA AGCTCCAAAG CCCACCACTA CTCAGGCAAG GGCGGTGTGG GAA TITAAAC CAAAAAGTGG AATGATGGGC TIGCAAAACG TTAAAAGCT TTGGCGTTT TCTCATTTGG AGAGGACCCA TI'GGGGGGAT TI'AGACGTGC TCACGCAGCC CAAGCCGTGC GAGTTTAGAT GACGCTAAAC GGGCATTGTA GAAAATATGG TTTTGGCTCA AATTCCATGA GCTCCCTTTA GAGCCTAAAG TCATCCCACT AGCGTGAGTG TTAGACAAG GTGGAAAGGG GCATGCTTAT TCGCAT
TATCCTTTAA
AAAATTCAAA
CGi'TAAAAC
AAAACATCAC
AGGAAACGAG
AAGCTTTGAA~
AAAATCTGGC
GTAAAAGCAC
GOCTACTAGA
CTGATGTGAT
CTGTGATGAG
TGCTCATGCG
TGGTGGTGGA
CACTCAGCGC
GGAGTI'TGGA
GGAGI T GT
GTGGATTATT
TGCGTCTAGG
CTAAAATTTT
AAAAACTAGC
AAACGCAAAT
TACTATCAT'
GATCATCTAC
CTTGCATGAC
TGCGA'TTTA
TI'TGGATAT'
TAAAAACATC
CACCAGCGTG
CGCTGATGTG
CATGGATCCT
CATGGGGCTT
AGCGATTGAG
TATGCCCCCA
AGGAATCACC
CATGTTTAAG
GTGCGAGCAT
AGAGGCTrAT
GGGGGATAAG
TGAAAAAATG
CGATAATAAG
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1236 9* INFORMATION FOR SEQ ID NO:281: SEQUENCE CHARACTERISTICS: LENGTH: 267 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .267 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:281 a
ATGGGTGTGG
GTAACTCTGG
GTGGTAGITG
ATTGGGGCTA
AAAGCCAAAA
TGATTGGCGA
GGGGTACGGG
GGGCAGGGGC
ATGCGGTGGT
CCATCACAAA
GACCACAGAG ATTGGAGATG ATGTrACCAT CAAGTTTAAG GGCAAACGCC ACCCTACTT TAAGGTCTTG GGCGCGATTT GCGTGGGCGA GCTTTCAGAT TI'ACCCACGG GTTCTACGGC
GGATCGT
TTATCATGGC
AGGCAACCGA
TGATGTGAGG
TGTAGGTGCT
INFORMATION FOR SEQ ID NO:282: SEQUENCE CHARACTERISTICS: LENGTH: 576 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEy: misc-feature LOCATION .576 (Xi) SEQUENCE DESCRIPTION: SEQ ID NO:282
ATGC-TATCTT
TTGTTACTGc;
AAATACCTTT
TCTCAAGAAA
GCTAACGTGA
TIGTCTcAAA
GAAAAACAA
ATGATAAACG
ATTAAAAATT
GYGATYGyCA
TI'ATAAGCGC
TTTAGTTr
CTAAAAATCA
AAGTCGTTAG
GCGATTITIT
AAGTGGATTr
AAAAAATATT
GCATTGAAAA
TAGAAAACAC
AG'FrRGAAAW
GTTTGATAAA
GGGTrrTGGCT
AAAAATACAA
CAAATGGGAT
CAGGCTGGAT
AAATGGTAAA
AGAGCTTAAA
cTATAkA.AAc
CCTCTATCAA
TFI'AAAAATC
AGGGGCGTTT
AAAGATTTAG
GCCCTACAGG
AACCCTAiTTT
AGCACCTTAA
AAACTCACGC
AAAACCAAGC
CAACAAGAAA~
GCCAACCATT
GCCAWT
CAATACGCCT
AAATCCAAAC
AGCAAATTGA
TGTATTTAGG
TGCAAACAT
AGTCTAAAAT
AGCAATTGGT
TAGAGCTTT
CCAGTTCGCC
TCTAACAGCC
TTTI'GTGGCT
CGCITTAGAT
CTATAACARC
GAGCTTGGGT
GATCAATTTA
GATTAATTTA
AAACACAGCG
CGATTTAATA
120 180 240 300 360 420 480 540 S76 0: 0*.
so 0 0. S S.
INFORMATION FOR SEQ ID NO:283: SEQUENCE
CHARACTERISTICS:
LENGTH: 348 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genornic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .348 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:283 0 ,0 *0 6
GTGCCGGCG
GGGYATGTGA
XTTGATAGcG
ACCCTTAAAA
GGTTTlTTGGG
TTGTATGAAA
TI'GGGGGGGC
ATGAGGYTAT
TGATCAAGCC
TCAATGAAAT
GGA'ITATCGT
ATTACTTIAT
TTTGATTrGG
TFTTAYYGT'
AATITI'AATC
ATTGATTTTC
AGGGCCTACC
TCAAAAGGAG
ATYCYTATAG
TTGTATTCCA
GITFI'TATCA
TTITCTATGA
ATCACGGCGT
CAAAAAACAT
YGATTT'ATGA
~TTGTTAAT
AAAAAAGAAT
TTGCTGGGAT
TTTTTATCGC
GCGAATGT
GCITTATCAT
TGGTGTGI-rG CTTrAAp.ACC
TTCTCAAI'IT
GTITAcTGcGrA INFORMATION FOR SEQ ID NO:284: Wi SEQUENCE
CHARACTERISTICS:
LENGTH: 489 base pairs (B3) TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL.
NO
269 (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE- NAMIE/KEY: misc-feature LOCATION .489.
(xi) SEQUENCE DESCRIPTION: SEQ ID NO:284
GTGGTTGTCA
AGAGAGCAAG
CCTACAGAAG
GACAAGCAAG
CGAGATATTT
TTTAAAAAAA
GGGCATCTTA
CGGTITTTAT
CTCCAGCAA
?I'ATTTTAGT
AACGCGCTAT
AAAAAAAGT'
GCAAAGAAGC
GGGTAGAAGT
G'ITATCCTF1'
TTCTTAAAAA
ACGAGCCAAA
GGTCGTTATC.
TAAGCCCGAC
AGAGCCAACG
GATCAAAGAA
GA'ITGA'TrA
AGAGGCTAAA
CAACCATCAA
TAAAGGTTTA
ATI'CAAAACA
ACCAAAAATA
CCTAA.ATTAG
AATCCTAATA
GATGAGAAAA
AACCACCGCT
GAACAAGATT
ACGCTCATCA
GCTCTTCTTT
ATTC'ITTCAA
AAGAAAAACA
CCATTTACAT
AAAACTCTTT
TGTTGTTACG
ATAACGACAG
ATGAGGCCCA
AAAAGAAGAG
TGAAACTAAT
CAAAGAACAA
TATCCCTAAA
TCAAAAGGT
CTTTGGGCAT
CAAAACTAGG
ATACAAAGCG
*4 0 0*0S00 o.f .06# INFORMATION FOR SEQ ID NO:285: SEQUENCE CHARACTERISTICS: LENGTH: 120 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NANE/KEY: misc-feature LOCATION 1. 120 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:28S ATGGATGAAA TCTATCAAAT CGCTAAAAAT AAAACCCTAA TCGI'ATCGC CCACCGCTTA AGCACGATTG AACGCTGTGA AGTCATCATI' GACATGAGCC AACACAAAGA CAATCTCGGC INFORMATION FOR SEQ ID NO:286: SEQUENCE CHARACTERISTICS: LENGTH: 135 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO
S.
S S S 5 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...135 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:286 GTGGCGGGCA GCTTTATTAT TGCTCTTTTT AGCGTTTTAG CGGATCAATT TGTGAGCGTG TTTCAGCATG AAAACGCCTT GCAACGCCTA TTTTCTCAAA ACGCCACCCA AAAACAAAAA 120 AAGAAGAGTT TATGT 135 INFORMATION FOR SEQ ID NO:287: SEQUENCE CHARACTERISTICS: LENGTH: 354 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO S(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...354 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:287 ATGGTAGCTT TAAGCAACGC TCTTTCAAGG GTTTTTGGTT CTGTGGCTGG CTATAAATTC CCTTCTTTTA TCCAAAAAAG CATCAACGCT CTTTATGTTA AGATCTTTAA AATTGATTTG 120 AGCGAGTTTG AGCCTTTAGA AAATTATAAG AGTTTGAACG CTCTTTTCAT GCGCTCTTTA 180 AAAAAGAAC GCCCCTTTGA CAAAGCCCCT ATATTTGCAT TGCGCCTTGC GATGGCTTTA 240 ATCACTGAAT GCGCTTTTTT AGACAACGAT AGCGCTTTAC AAATTAAAGG CATGCCCTAT 300 AAAGCGCATG AATTAGTGGG CGAAATCAAC CCCTTAAGCC CTCTTTTTTC TATG 354 INFORMATION FOR SEQ ID NO:288: SEQUENCE CHARACTERISTICS: LENGTH: 600 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...600 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:288
ATGGCAGTGT
GACAACCCTFr
TATGATGACT
AAAATCACGC
GATAAAAGCA
GCCTrTGAAA ATTTTGCGrr
GTGTTAGACA
TTTTTTTCTC
GACGGCAAAT
TAAAAAAGAT
TTGAGCCTGA
ACCTCAAAGA
TCACTTACCA
TTGATI'GGCA
AACGCTACCA
CCCCITATAA
CGCAAAAAGG
ACATTAAAGT
ACCGCTATCT
GATAGGTTTG
AATCAAF1'CC
AATCCATGTG
AGATATTGAT
CTACCCCTTA
GATCCAAGAT
AATTTTGCGC
CCCTTTGGAT
CGGCACGCAC
TTTGGAAGAA
GTGGCGGT
AAGAATTTGC
GATTTGCCCA
GGCTCTATCC
AAACTTTCCC
TI'IGATTrT
TCITTTTGTGT
ATTTATCAAA
AAAGATTATT
AAAAACGGGG
TAAGCGTTTT
AAGGGGGCTT
CGAGCGCTAG
ATTCTAAAGT
AACACACCCT
TAATGGCAA
TAGTCAATCC
ACATGGATTT
ACCGCATCAC
CGTATGAATT
ATTAGCCAGA
TAGCGGGATC
GATCTITAAAA
CGTGGGTATT
TAATCAAGAC
CAACACGATG
TTATAGAATC
AAACCAGAAG
GCTCATTFI'A
AAAACTGAAA
0 INFORMATION FOR SEQ ID NO:289: SEQUENCE CHARACTERISTICS: LENGTH: 237 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 237 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:289 00. ATGGGCGGAT TCACAAGCAT ATGGCATTGG GTCA ITGTT ITTGGGGCTA AAAAGATCCC AGAATFIGGCT
AAAGG'ITTAG
00 AAAAAAGCCG TGAAAGACGA TGAAGAAGAG GCTAAAAACG CAAGCAACAC AAACCAAAGT GCATGAAACT
AGCGAAATTUA
INFORMATION FOR SEQ ID NO:290: SEQUENCE CHARACTERISTICS: LENGTH: 618 base pairs TYPE: nucleic acid STRANDEDNEss: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (Vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .618
TATTAGTGAT
GCAGTGGGAT
AGCTAAAAAC
AAAGCAAACA
TGTGTTGTTA
TAAGAATTTC
CCTAGACGCT
AGAAAGT
(xi) SEQUENCE DESCRIPTION: SEQ ID NO:290
GTGCGTTTGA
GCAAACGCTT
GTCAAACAAG
GAGTTTAACC
AAAACCCAAA.
GTGTTATTCA
GTGCCTGATG
GAGITGAACA
AGC'FrTAGCG
AAAGAGCGTC
TCAGACAGCG
ATGCGGCGGT
TAGAATACGA
CCATTGGTGA
CTATGGTGCC
AAA'FTI'AGG
TF1CTATAA
AAGATAAGGA
AACTCGGCGA
AAGAAGAAGT
CTGATGAAAT
CGAAAGGT
TGTGGTGGAT
GCCTTTAAGC
TAACCAAAAT
TATGATTGAC
TTTATT1'ATG
AAAAGTGATC
AGTGAAATCC
TTTGAGGAAA
AAGATATGAA
CGCCACGCTC
GG CAAGTATA
GATGAATSGS
AGAGGCGATG
AACGCCACCT
TTFI'TAATCA
GTGCCTTTCA
ATGTTTGAAG
AAAGTAGAAG
ATTATTITTAG
TTTAAACTCT
AAATCGCGCT
ITAAAAAAAT
ACGTGGCGGT
TGAGTGAAAA
AGGTATATTT
GCGAACGCAT
AAATGAACGA
ATCAATTAGG
AAAAGA'ITAG
TAATCAAAGA
CGAAGACGGG
CAACGYCCTA
GAGTAATTIT
AATCATCTAT
GGTGTFI'ATA
GCTGGAAGTG
AGAAGAAGAT
GCTTAATGCA
AGGAACCCTTI
TGAAATCTCT
120 180 240 300 360 420 480 540 600 0 a INFORMATION FOR SEQ ID NO:291: SEQUENCE CHARACTERISTICS: LENGTH: 294 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .294 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:291
GTGTGTTTTA
ACCCCAAGAC
GTGGCGTTTG;
TCAGAAGCTA
GA'FFIGGAGA
TATI'GCCTT
AGCTCCCTAT
AATTAGGCGC
AACGCTI"II
GAAAAATCAA
TI'GT1'TAGGG
CGTGGTGGTG
AACGAGTGCG
AAACTCCGCT
AATGGGGCGA
GTTTTAGGCA
GATI'TGGATA
GTI'GAAATCA
GAAGTGTATG
AAAGTGGsAT
CGCAAATCTT
AGACCACTAC
AATACCAAGT
GGGCGTTAAT
TI'GCCC 171"1
TAAACAAGAG,
AAGCCATCAA
GACTAGCCTT
TTTGCCTAAG
ATTA
120 180 240 294 INFORMATION FOR SEQ ID NO:292: SEQUENCE CHARACTERISTICS: LENGTH: 591 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/ KEY misc-feature LOCATION .591 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:292
ATGAAAGGCT
TCTTATG'rrr
GGCGITCTA
TTTGAAAAAA
TTFI TTAAAGC
ATAGAATI'AG
ATCGCTCCCT
CTCAITAACG
ACGCAAAATT
TTATTGACGC
TATGGCTTGT
TTAACAATTC
AAGAGCTTTA
ATCCTATCGC
AGCTCAAACC
TGGCTAACCC
TACTCCCCAC
GCTATTICGGT
TTAGCGCTCC
TTTTGGGCGC
AATCTCTTTA
TAAGGGGCGT
TCTTAAAACC
TCTAGCGAAT
CCCTTTTGTG
TAAAGATTTG
AAACGCTAAA
CGCAGTAGAT
TAAGGGAGTA
GTTTGGGG
GTTITTGTTG
TTAACAGA.AA
GGCGTGCGTI7
AAAAAAGAGC
GTATITCTT
CTAGACACTG
GAATACACGC
GCT1TAGCGG
ACTTITTGTAA
CTTTATTTTT
GTTTTTTGTG
AAAGCGTTGC
TTGCGA!FTGA
GCCAAAGCTA
TCTACCATGA
ATAAAATCTT
CCCAAAGAAT
AAAAATATCA
AGGTGGTTAT
TTAAAAAATC
GGCTAATGAA
GTTTATAGAG
TATGACGGAT
TCAAGAGGGC
CGCTCAAAA.A
TTCAGCCATG
TGTGAATATC
TTATATT1'TG
T
INFORMATION FOR SEQ ID NO:293: SEQUENCE CHARACTERISTICS: LENGTH: 204 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE:.
NAME/KEY: misc-feature LOCATION .204 (xi) SEQUENCE DESCRIPTION: SEQ ID, NO:293 ATGTGTTCTA AAAAAATAAG AAATCTCAIT TTATGCTTTG GCTGAAGAA.A ATATCACCAA AGAAAACATG ACTGAAACGA CCTAAAGACG CTCCCATTCT TFI'GGAAGAA AAACGCGCCC' GAAAATGA.AG TGGCAAAAAA GATT' INFORMATION FOR SEQ ID NO:294: SEQUENCE CHARACTERISTICS: LENGTH: 279 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .279 GTTWATITr AAGCTTGTGC ACACGACTGA AGAA.AACACC AAACTCTAGA GCFI'AAAGAA (xi) SEQUENCE DESCRIPTION: SEQ ID, NO:294
GTGCTAAAGA
GCTTGCAGTG
AGATCCACTA
GAAGCCAGCG
AGCGATCAGG;
CATTATCCAT
GGGTGCAAAA
AACTTAAAAA
TGAAAAA-ATT
AAAAAAACGC
ACGATTAGTC
ATTGCGCGAT
CATGAAACAA
GTGGATTAT
CGITI'TAAAA
ATACITTI'AA
GAAAGCCACC
ATCGCTCTT
TITGGGAGT
AAACGAAAA
ATCTCCCT
GGTATGCGAT
TAAAAGAAAA
TTGAAGCGAT
AGCGACAAAC
AAACITCCAT
GGGCATAGGA
AGAAAAAGCG
INFORMATION FOR SEQ ID NO:295: SEQUENCE CHARACTERISTICS: LENGTH: 219 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .219 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:295 4 4 4* 4* .00 *0 GTGGGCXITA TTAGGGGGAT TATCCACAGG CCAGAACTCA AGCGCTTTAG ATAGTTrGAA TCGTAAGAAT TTACAGGATC AATTCTTGCG CTACTTTCAT TATGGTAACG CATGATGAAA ACAAAAACCC TAGAAATCAA AGCCCITAALA CAAGAGCAG INFORMATION FOR SEQ ID NO:296: SEQUENCE CHARACTERISTICS: LENGTH: 804 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: mnisc-feature LOCATION .804 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:296 TTITTATAGA TGAGCCmTII1 TCATCAAAGA AATACACCAA ACGAGGCGCA AAAGITAGCC
GTGATTTI'TA
ATGGAATFI'A
TACCTCATCC
CATGAATGT
CGAAGACAGA
TCGCTACCGC
TCAGCGTGTC
CCCAAGAATT
TGAAACTCAT
TCGCAACGAT
TAATAATAT1'
CAGCTACACG
AGAAAAGCAC
TATTGAAAAA
TATGCGTAAA
GACAGGATCC CAGCTCCTT CCTAGCGAAA AAGAAGAGAT GCCI'AAAGC CTAGCGAAGT TACACCAGAG AAGCGGGCGT GCGGCITTAA AATACCTAGA
AAGAGACAGA
CGCTAAAAAC
GGATAITAGC
TAGGGAT'TA
AGATAACCCG
CACAAAAAAG
AACGAAAA
GAGTATTTAG
ATCGTCAATG
AAGATTAGAG
TCCGCCATTA
CCTAAAATCC
TWWAACGCTT
GCGCTGGGAT
GGCGGACCAA AAAAAGCGAA GAGGTGAGAG TAAAGXTF AACGCATGGT G1TTGAATT GCTTGGCATG GACTCCAGTG GCAAGGGGGA ATI'GAAACTC TTGCC'T TTC TGTI'GTCAAA CTAGCGAGAC CGATGCAGAG ACGAT'ITGCA CTTGCATGTC CGCTATGGCG AGCG
GACAAAGATA
TGCGTCTCTA
GRCCCCATAG
GGCGGTGATG
ACCGGGAGTT
GTCTTGTTGG
AATWAGAAAA
CCTAAGGGGC
AAAAAGGCGG
TCACGCCTGA
ATGAAGAAAA
TGCT1'AAAAT
TGGGCGACGT
ATAACGAAAC
AGAA.AAAAGT
TACGCCTAAA
AAATGAAGAA
TAACCTTAAA
TAAAATCGGT
TGAAGCGGT
GATGAAAGAA
CTTAAAkAGTG
GCTGAAAGTT
GACGGCCCGA
INFORMATION FOR SEQ ID NO:297: SEQUENCE CHARACTERISTICS: LENGTH: 498 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 498 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:297 ATGGGGTGTI' CGTTTATCIT GGGC TTT CAA GCGTGTTGAT AATGACGCCA AAAACCAACA CATGTI'ACGC CACTAGATIT CATGTTGTAG GTATTTTAAT GATAAGTTTC AAGACGCTTT CAAGTGTTGC CT TTT CAAGA TCCGTTTTGG ATTGAAAGG GATI'CCCATA GTCCCATT TAAAAAAGIT AGGGTI'ATT CGGITGCGCG ATGAATCCAA ACCAGTTCAA ACTCATGAAA TAATI'ACCCG GTGCATATrG GCCACGCATr CAAGTGAGCG AATTAATCAA ATCCAAACTA TGAAAAAGCT TTGAATGTGC GTGGGTAGGA ATCFI'AGAAG
CTAAAATGTT
GCGCTGAGAC
GAATGACAAC
TTCAAGCCCC
ATAATCTAAA
TTITTGAAAA
AAGATAAGAA
ATTTGAAAAT
GGITGCTITG
AAAAAAACCA
A.AGTTCTGAA
ACAAAACCAT
ACCCTATATT
AAGAGGCTAT
AAAGATrrr1'
GAATTTAAAA
INFORMATION FOR SEQ ID N0:298: SEQUENCE CHARACTERISTICS: LENGTH: 432 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .432 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:298 ATGGATAGAA AACTCTTAAG ATTATACCAG CCCTTAAACG CTTATTCTTA CAATAGCGAT TCGCTTTTTT TATACGATTT TTCACGCCCT TTTATCAAAA ATAGCGGCGC GATTITAGAC 120 ATAGGCTCAG GGTGTGGGGT TCTAGGCTTG CTCTGCGCTA GAGACAACCC GCTAGCGAGC 180 GTTCATTI'AG TGGAAAAGGA TAGCAAAATG GCGTITrGCT CCCAAAAAA CGCCTTAAA 240 TTCCCTAACG CTCAAGTGTI TGAGAGCGAT TITrTAGATT TTAACCCTCC GATTTrGTAT 300 GATGCGATTG TGTGCAACCC TCCTTITrAT GCTTTAGGAT CTATTAAATC TCAAATTAAA 360 GGGCATGCGA GGCACCAGAG CGAATTAGAC TTCGCTTCTT TGGTGGCTAA AGTGAAAAAA 420 TGCCTGAAAC CC 432 INFORMATION FOR SEQ ID NO:299: SEQUENCE
CHARACTERISTICS:
LENGTH: 141 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION .141 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:299 ATGTGAGTG CGTTGGTGAT GCTGCCTiT ATGGAGGTTT TTTATATTT CAATTTTCCG 'ITGTGGCTCA ATCTI'TCTT AGGGCAAACC ATGGAGCGG TGA'ITTTT CAAGTTGGAT 120 AAGTTGATTT TTTCTAAAAA A 141 INFORMATION FOR SEQ ID NO:300: SEQUENCE
CHARACTERISTICS:
LENGTH: 387 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .387 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:300 ATGAATACTA TATAAGATA TGCGAGTTTA TGGGGCTTGT GTATTACTCT AACTCTAGCG
CAAACCCCCT
AAITT'AAAGC
TCGCCTAAAG
GATAAAGCCG
CAAGCGCAAG
GTTI'TGCCT
CTAAAACCCC
TCATTGATYC
AAACAGCGAC
CITTGGGGCT
AACTCAGTGT
ACTTTGAACG
TGATGAAATC
GCCGACAAGT
CACGATCAAT
TTATGAATTG
CAAGCAAGCG
CGAGTTA
AAGCAAATCC
TCTTARRAG
CAAGAGATCG
CTAAAGGGGG
ATGGAAGAAC
TTAACAATTA
CGACACCGGG
CTAAATACCA
CTACCACCAA
CACACCATCG
TAGCCATAAG
TrT11rwCCc
TGAAAAAAGC
TCTCAGT'ITG
CCAAAGCGAT
INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 726 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .726 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:301 *9 Sn.
me S. S
S.
S*SS
*S
S
S
*SSS
S S 5
ATGGTTTTGT
CTTTTAATCA
TACAATGGCG
TACGCTCATT
TATITTCTIA
ATTTTTTACA
TTAGAAGAAT
ATGCTTAT
GGGGTCTT
ATAGCCAGCA
AAGCATTATC
TITGCCACCT
GAATGC
TTCTATCCAT
ATCTTGGCCC
GGAGTAT'GT
CTCAAGGCT
TITTGGAT
CCCCTITAGT
TTGGCTCTAT
TCTTAGCGGT
TITCTATAGT
TGATITTCAA
GIII--rCG'rr
TGTTGCAAAC
TATCCTTTTG
GAATTAT'GC
T1T1'GCCGGT
CGTAAT'CT'
GGTCTCTTAT
CCTTTrCT
TTTAACGCCC
CCCGCATITC
CCATCAAAGC
TFITITGCTAT
CCTAAYGCTA
AGCTTTAATG ATTTTTTAAG AGTI'GGCGT T'TI'TGGAGC CAAACTAT TACCGCAATC GTGTTCGCAT GGGTITTAA TITGAGTTTAG TCATCAATAT ITGCACCAAA AATATrATCC ATTAAATATT TITI'AAAATC CITTATITCA TTCCCI'TAT CYCTTrTCA*AAAACACCAT TATCAAAATT TACTCAAACA CTT7rI'T17CCT TGATTCCTTT ACGCACTACY ?TITTATCTTI
CGCTAGAATG
TATCTITI'AT
TTGAATGAT
AGCG'rrAGTG
TITTGCGTCT
CCATGTCGT'
GCTCACTITTT
AGGGGTCITr
GAGTTTGGAT
GCACCGAITG
TTrTAATITr
TAAAGAGAAA
120 180 240 300 360 420 480 540 600 660 720 726 INFORMATION FOR SEQ ID NO:302: i)SEQUENCE CHARACTERISTICS: LENGTH: 378 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: 6ircular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .378 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:302
ATGCAATACG
GCAAAACTCA
TGTATTGAGA
TrCACGGAGT
ACAGGCI'AT
AGTAAGATTG
CATTCAGATG
CTAACGCT'A
TTGAAATGCT
ATGAAGACAT
TGTTGAATAT
ACACCCATCA
ATTrGGTGTT
AACTCGCC
TCAAGCCTAC
TTATGAAGGG
TGAAAAGAAG
TTTAGACTAT
AATCAA.AGTT
GAATGTGGCT
CAGCATAACC
AT2TTTAAGAT
ATCTATTATA
GAAAAAGGGG
TI'AACGCAAG
AGGGGGI'GT
GAGTGAGTGT
'FITCTCGCA
TTAATAGGGT
GGRAAGTGGC
CCAATG;TGGA
TAGAGGCATG
GGAATCCCCG
AGCCAAACGC
TACGGATATT
GGTGTATCTT
AAATGACGCG
GAGGGAAATC
INFORMATION FOR SEQ ID NO:303: SEQUENCE CHARACTERISTICS: LENGTH: 429 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .429 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:303
S.
*fr *5
S
S
ATGATG'rTTG
TTAGCTGGGA
TCTTATATTT
G'FTTTTITAA
ATGTCTATGG
GGGATl'GTGA
AAAACCCAAA
TFI'TTGGCA
ATAACACGCT
T-TAACTT-r
CGCAAATTTC
AATCCrI'GAT
CCAAGCTTAT
TCC77I~rrGG;
GCGITGGTITT
TATCAATTTA
TFI'AAGCCCT
TTAGA:;GAT
G7T C0_,G
CCATAO-,.
TTGCA AGCCA3ZAAj 1
TTTGAGACAG
TGCGTGTTGC
ATTAAAGATG
GGG'IT CGC
TCGTTTI'CCT
TI'AGGCGTGT
TCTAACAGCA
CGCCTCTr
CTI'TGATCCC
*GTAAGGCTAJA
TCGTGTTTI'T
GGGTGAATIA
'FrCGI'ITGc
TGCAGCGCTT
AACYTCGCTT
GGCGTATATG
AAGGGTTrCG
GGGCGTGGGC
TATCGCTGGG
ATTIITGTAT
TACCCCTTTC
120 180 240 300 360 420 429 INFORMATION FOR SEQ ~34 i)SEQUENCE CHARAC7r_::S: LENGTH: 252 base pairs TYPE: nuclei= acid STRANDEDNESZ: :uble TOPOLOGY:- ic.a (i)MOLECULE TYPE: DNA (gencmic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature 279 LOCATION .252 ixi) SEQUENCE DESCRIPTION: SEQ ID NO:304
GTGCTGGTGG
TTTATCAAGC
GTAGAAGCTT
GATGGCCGGT
TTAAAJAAAGG
TGGGCAAACC CAACGAAAGC TATGCAGATA TIGTAGATTI' TAAGGGCCAA ATCGTI'TTA ATGAAAATrr AGAGCATTrG GGTAAGAAAA TAGACTCTTT GAGCGCTTGT AGGATTTTAG
GC
CCCACGCCCG
TCAATGAAGA
ATAAGCGGAT
AGCGCTATTG
CATGAGcAT
TAATTCTAGC
CGCTACCAAA
CCAGCAGGT
INFORMATION FOR SEQ ID NO:305: i)SEQUENCE CHARACTERISTICS: LENGTH: 465 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .465 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:305 a a S.
ATGCGGATAT
TCTTGGGGTA
GACTACGCTC
CAAGTGGCTA
CCCAGAACTT
GTCATCAATA
TCATGGC?22A
AGAAAGCCAC
TAA'FrCTCAA TCAA ITI FC
ATGCCAAT'C
GTCAAATTCT
TTGAGCCGAA
ACGGCATCAT
TGGCGASACC
TCTTTCCAA
AAACAAGCCA
TTTGAAAAAc
TATTAAGCTT
TGGGAAACAA
CATGCTCACT
GAGTTTGGGG
GAGCITTGAG
TTTTI'ATrCA
CCAACGCTAC
ACT'FrGGCTT
AAAAACCCTA
GAAATCAATC
TATGGGGGGG
GCTTTTGGCG'
GGCATTThG
ATGTGGGGGC
GATCAAAGGC
ACGCCTTTAT
ACTATAATAG
GTTTAACAAA
CTATGGACGT
GGATACAATT'
GGGAACAAGC
TCGCM
TTTGACGCGC
GGGGTrI"ITr
CGAAGCGGCG
CATI'GCCGAT
GATGGTI'AAT
GGCCGGCAAT
CCTl'GTGAGC a.
INFORMATION FOR SEQ ID NO:306: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 513 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature CB) LOCATION 1 .513 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:306
ATGAATGTCA
GAGAAACITG
CAATTAGCGA
ATGAGTAAAA
CAAAGGCGTA
CAAAATCAAT
GAAAGITTG
GTCAATAACA
TGCTGGGAAT
AAAAAAAGGA
GGAAAGAAAA
TCCCC-ATTCC
CTTTITTATGA
TTGAGATI'GA
F1'AATGAAGT
ATGAGCTGGR
AGATCCAAGA
TTATCACTAG
AAAGCCACAA
CACTACTTTT
TGGAGTTGGA
TGTCTCGCTA
AAAAGAATGC
GTTTGAGCGG
GAGGGCGCT
GGGGATGGGT
CCGTAAAGAG
AGTGGAAAGA
TTAAGCAGTA
GTGCTCA'FrG ACGATT1'CA
CGTGAGAGTA
TATTTl'CATG
TGTGCGGGCG
CAAGAGTTGC
GGT
TTGATAGGGT
TAGCTATGGG
GGGGCTTTGT
AAGAGGCTAA
TCAGACAGTT
GGACTATAA
ATGCGGATT
TGTTTGACAA
GGATI'GTTTG
GAGCATTGGT
GGGTGGGGTG
ATTAGCCCGT
AGAGATOTAT
ATTCTrTAAT
GGCTATAGCA
TAAGCAAGAG
120 180 240 300 360 420 480 513 INFORMATION FOR SEQ ID NO:307: SEQUENCE CHARACTERISTICS: LENGTH: 423 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .423 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:307
ATGTGGCCGT
GTGGCAAAAA
AATAGATCCT
TTCATTAGTA
A'ITGTGGCTA
ATGAACTACC
CAAGCTITAG
CC
RAAAGCTTTr
ATATAAAGAT
TAATCI TCACTGCTrI
TGGCGATCAT
CC'TAACGCT
AAAAAAAG'T
TCTAAAACCC
TTrGCGCTA
CCTTATCAAG
GTTAGCCTTI
GAACGGCATG
CTATACCACA
CCCTAATTTG
CTAAAAGAAA
AAAGCGGGCC
CGTTA'TrTGC
'ITTGGCGTGG
AGTAAGGAAT
AGCCCITATG
CCTT'I'lTCAG
CGAGCCTTGC
TAAAAAGGGC
GTFI'TGATAA
CGGTTGGCGT
TrGAAAAAAA
GGATCAGCGA
YCCCTATTTG
CCTTGTGGGA
TTATTTGCCA
AAGCCAGCCT
GATGGTTTTA
GCTTTrGTG AGAAGTGGTr
CAAACCCAAA
120 180 240 300 360 420 423 so. INFORMATION FOR SEQ ID NO:308: SEQUENCE CHARACTERISTICS: LENGTH: 210 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc_feature LOCATION .210 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:308 ATGGTATCGT TGCTTGGCGC GCTTAAACGC ACCCCTI'GCA GCACTACTAT FrGCTATAT' CTATCATGCA GTAAATAATT CATCAAGTCC GGGAGTITTT TTCATCACGA CATGCACAGG CCATGCGCCC TTTCGTT2CA AAACGCGCTC INFORMATION FOR SEQ ID NO:309: SEQUENCE CHARACTERISTICS: LENGTH: 459 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAMAE/KEY: misc-feature LOCATION .459 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:309 CTAATCGCTT TTATCTTAAA TTCTAACGCA ATGCCCGCCc GATGGAAGCG AGAAACGCTC S.
S
GTGCATCATT
TGCGAAAAGA
CGCAAAAAGA
GCGGAAGTTT
CAACGCTCCC
TGCTCGCATG
CAAGCCACC
YCCACAAGCC
TGYAACGGCT
TTI'GCACGAG
TCGATTC'ITA
GCCCAGAATT
AATACGGCTC
CCGAAT7r1TT
CTTI'AGATTA
CAGAAAGCCA
TTTAGACTCA
CAACTGCATA
CACGATCAAT
GGCGATCGT
TAAAAGCGAG
AGGO=-G
TGTCCAAGAA
TAAGGZ;AGAT
GGCTCTGAA
AGGATCATCA
TIGGGGCGTr
ATGGGGAATC
TITCTAACGA
GCGGTAAGCC
CCTTCAAAAd
GAAAATGT
GGTGTATAGG
CGCATAAGGG
GCATTTATTG
GGTrTGAAAA
GCGAACAAGA
CTAATI'ATAA
AAGAATCCAA
CTGTGGGCTG
CGAAGACAAC
CGGGTI'GTGT
CGCCAGCACC
CGCTAAAAC
CGAACGCATG
AGAAGAGTTT
INFORMATION FOR SEQ :0 Wi SEQUENCE CHARATER::7:CS: LENGTH: 549 Lase pairs TYPE: nuclei= a- id STRANDEDNEZ:_' azuble TOPOLOGY: :c (ii) MOLECULE TYPE: igenomjc) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .549 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:310 ATGGCTArT
CATGAGTTGG
TTATCG-,IT
GAATTGATT
CTGGAATTAC
GAAAXFFI'AC
TGCCTAAAA
GGGAAAATCC
ATGCACCCCT
'ITGAAATTA
GGGGGTGGTG
TTTTAAGATC
CTTATGAAAG
GGTTAAAITC
TCAAAGCGCT
TTGAATTGGA
AACAAAGCCT
TAGCC7I'Tr
TAGACATTAA
TTT~TTTATTT
CCAAGCTTTA
GTTTIATTTCT
TGGCTTTGAT
GTATrTTTAAA
GCAAAAGGAT
GATAGCGCCT
TGGCGTGGCA
GCGTTATGAT
TTATCGTCCT
GGGTTTGAA3A A1AAACCAAAC
'ITTTCACGCT
TTAGAAAAAT
CGCATCATCG
CAAACTI'ACT
AGGGATAAAG
TCCTTCATTG
TGATGTGGGG
CGCGCTTAGT
GCTCTTTAGC
TGAACGTTGA
TAGAGAGCCT
CTrrAGGGCA
ATGGGCGTTG
ATTTTAGA
TTGATAGCGA
TI'CAAGCATG
CCAGTGCGAT
GGTGTTAGAJA
AAATGACACT
GCTTTAA
TGGGCTAGTI'
CGTGTTAGAG
AATCACTCGC
AAGAAAAGGc 120 180 240 300 360 420 480 540 549 *5 S.
S
*5 INFORMATION FOR SEQ, ID NO:311: SEQUENCE CHARACTERISTICS: LENGTH: 201 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc -feature LOCATION .201 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:311 ATGCCGGA ATTCTAAACT ACAACCTGCT AAGTTAGGGA AAAA'rITTA
CCCTGTGGAT
CATTCTAACA GGAAT= CTrTTTCTCTC A'ITCTGTCTG TATTGTI'ACA
CTGGTTGATT
TATTITTTTAT TTGAACACAG AGAAGArlTI'I TTTCCTTCAA. AACCCAAGCT
CGTTAAATTA
AATCCTGAA ATTTATTGGT
Y
INFORMATION FOR SEQ ID NO:312: SEQUENCE
CHARACTERISTICS:
LENGTH: 519 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: No (vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .519 120 180 201 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:312 GTG7IITAG
AGCGTGGGTA
GGGCTATTIGA
AACCTCTITG
TITACTGGAGC
AACACCAACG
ITAGACAATC
GCTAATATCA
AAAGAAT1'AC
TTICAATCGTG
AAATCCCTAG
AAATCATCGC
AAAA.AGTGGG
GCTTTCATAA
AGCGAGACAT
CTAAGAACGC
ATAAAGACAG
AAGAGCATGC
GGCFTl'GAGC
CGGATCTAAA
GCATTACGGG
CGTITATCAA
TTAATAGAT
TGTTAAAATc
TCAAAAAAAA
AAACCCTAAC
C'TTITGAA
TGAAAATAG
GATCCCTTTG
TTAGAATTTG
AGCTTTGATT
TGTAACCTCT
ATTCAAAAAG
GAGTTGCTTT
GAATCAAGCG
GCGTTCAAC
ACAGCCTGTT
CGTTAAGGCrG
AT'ITGAAAGC
TAGAGGTTT
CTATTATAAG
TCAAAGCCTT
TTAGCGCTTT
GG IIIcTAC
TTCTCTFT
ITTTGAGTTrT GGATTrAAAA AGAAAAG2T
AAGTGTGTTA
AAAACGCTTr
CAAACGATTA
GAGTC7 TTrC INFORMATION FOR SEQ ID NO:313: SEQUENCE CHARACTERISTICS: LENGTH: 777 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 777 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:313
ATGAGTC'FTG
CGCTTCCCTA
GT1'GCAAGCG
GACACTITT
AATTTTAAAA
TTI'AACATGG
ATCGC'TrAG
ATCAATATGG
GATITTITCA
CCGTGGCGTT
TTTTGGCTCG
GAAATGGCTA
AGGGATTATT
CTCCAAGCGT
ATTATTCTAA
CTTrATTTI'Cc
CCCACCTI'CC
TTGATCTT
GCTTITTTGGT
AG'rITrTGAA.
TGTTTFIAGA
AAGAGCACTA
CTGTCAGTTC
CCAACCTTTT7X
AAGACCAACA
TITATFFTAG
TATGGCGGGC
AATCATTTCC
GCTGGATA).T
TTITrAAGCC
GCGCTTI'AGC
GGCGAATTTA
AACTAGGGGA.
GCGTATTI'A
CCCTAAAAGT
TTTGAACGGG
TTGCACCCCT
AATGCAATCT
GATAAAAAAT
TTCTTG11.. GTGCCGGCTC
ATAGATGTGG
GAACCCACTA
TTITGTGATT
CAAAACGAAT
GAITTATGGC
AAGGATCTI'
GAATTGCCTA
ATCATCATGC
CGTTTGATTT
T1'TAAAAACG
TTTAAAACCC
ATTTTGAAAA
ATACGGTGTT
AATrGcTTGG
ITI'GCGAACG
TAAAACGCAT
G'CGAAAATGG
TCTACCCTGA
TTCATTATAA
TCCATTTCAT
GCTATGAAGC
ATTTTI'TrAA
ACATCCGATC
AAGIF7'TcGA
TTGCTCGCTT
TTTAGGCGAT
CATGGTGAGA
CACATGCAAG
CCATCAGGGC
GTTTGAAAA
GCAGTGTrlA TTGCTATrCT
CAAATACAAG
TGAAGCGAGT
AGAACGCCT
AAAAACGATT
ACTCTCT
120 180 240 300 360 420 480 540 600 660 720 777 INFORMATION FOR SEQ ID NO:314: SEQUENCE CHARACTERISTICS: LENGTH: 582 Base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE: TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANlTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter Pylori (ix) FEATURE- NAME/KEY: misc-feature LOCATION .582 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:314
GTGAITGTTT
GCGTTCATrG
TTCGCGCAAT
AATGTGAGTr
AGTI'TTAAGA
ATCAAAACCG
TCAGGCTCGC
CAAAAAAATA
GTCTTTTCTA
ATTTTGCAcc
GCAGCGCGGC
TGGGCATGGC
TAAAAACCT
TCTTCATGGA
CTTATCAT
CTCITTTCTT'
ACCAGCTCTT
TCTTAAATAT
TGTTAGCAAC
AAAAGAGCCA
GGGGTTGAGC
GATTTCTAA.A
C'FrITTGGCC GAAATTC'Tr
TTATGCGCTA
GGCGCAAAT'
TAAFI'GCAA.
TGCTCAAAAT
CCCTTTTAT'
AGAAAACGAG
CA7ITTTTG
TCGCGCTATA
CTTITFTCA
GTCGTCATCT
TTGCGTTTTT 1
GGGGAGTT
GAAA.AAAAAG
GACATCCACC
TTAAAATACC
CCGGCTAA.AA.
GGTTTCTAT
AAATCAATGT
TTACGATAGG
TTTTACTCAT
TTAGAGAcGC
CTTTCGTGAT
GGATTCTTGG
AGCTCCTTAT
TAGAATCTAT
AA
GTCTTTGGGG
CCAAGAAGAA
GATGCAGATT
TTTAGTGATG
TAAAACCGCC
CTTTTTAAAT
TTI"TTACAC
TCTCATGGTG
CGCTCAAT
120 180 240 300 360 420 480 540 582 INFORMATION FOR SEQ ID NO:315: SEQUENCE CHARACTERISTICS: LENGTH: 396 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geriomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 396 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:315
S.
S
S. S
S
S S
S
S.
S.
S
S.
*SS S
ATGWTCTATC
TTATI'AAATT
ATTAACATCG
G'ITGAAGATT
C71-TTT1CATA
CTTTCTTTA.A
GTITTTAGGcA
TI'ATCAATAC
CTCTTAACAC
C'ITTTATAGA
TCACGCTAGC
ACACCCCTAA
AAAATGATGG,
TGGGTGTT
AGGAGTGCCT
ACTGGAATTA
AAATAAAGAG
TTGCGGGACA
AAAAGCCACT
AATTrAT
TAAAAATGGG
CATTIAGTGG
AGGGCTI'TAA
ACGATTTT
GGCATGGCAG
CTCATCCCTA
AAAGGAGTCG
T07"ITT GATTTlGTGAA
GGCATGAAT
TAcAAAcTTA CGG'TrrrAT
AAAGCAACGA
CGCGTTATAT
AAATAAAGGG
TAACGCTAAT
TGAGAGAGGG
CGCCGCGCGC
ATrTI'AGAG
CGGCATGAGC
INFORMATION FOR SEQ ID NO:316: SEQUENCE CHARACTERISTICS: LENGTH: 639 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Nelicobacter pylori (ix) FEATURE: NAIM'E/KEY: misc-feature LOCATION .639 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:316
ATGATTAAAG
ITGCGCAITA
ACGCT1'YTAA
GAACACCAAG
GTGGGCATCG
CAAGTCGCI'
ATAGCCCACA
AGCATCGCCA
AATTTAGACA
AACGAAGGGG
GTCTATCGCC
CGATTGATAT
AACCCAAAGA
GCCATFI'GGC
ATATTTATGC
TITFCAATC
CAATCCTAGC
CCCTAAAACA
GAGTGCTITC
CCACTAGCGC
CGTI'AGTCTT
TAGXAAAAGA
TTCTCATGST
AAGCYTGGYG
CACCATGCTA
CCTAAATTICC
GCATTACCTr
CAAGCAAGAA
AGGCGTGGGC
TAAAAAACCC
TAATCAAGTC
AGCCACGCAT
ATCTITGATT
TTTGAAAARC
ATTITAGGCG
AAACCGGATA
AAAAAGCTT
TTI'AAGGGTT
ATAAATCATT
GAATTGAGCG
CAAATCATTA
ATCAGCATGC
GATGAGCATT
AAGGAAAAA
CTCTTTRTRA.
TGAGCGGGAG
GCGGAACAGT
TGGAATTGCG
TTAGCGCTTT
CCCTTAGA
GCGGCCAGCA
TCGCTGATGA
TGCAAAATTA
T.AGCCTTCAC
TGGCGTGAAT
CGGTAAAAGC
CAGTTTGTrA
GCGCTTAAA
AGAAAACTrG
ACAATTAGGC
ACAACGCTIA
ACCCACCGGG
CAFI'ACAGAA
TTGCTCTCAA
INFORMATION FOR SEQ ID NO:317: SEQUENCE CHARACTERISTICS: LENGTH: 228 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ATI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAMIE/KE'1: misc-feature LOCATION .228 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:317 ATGCTTGATA AACGCATI'AA AACGCTTI'A CTTTrTG GTCTI'AATAT GGTGTGTI'G AGCGTGAGTT TI'ACCAATAA GCCTCAI'TG TGTTGGT 'FFFIAGTGTT AGGT1'GTTAT IrAGI'rIATG AGTGGCAAAA GAAACAAAAA AAAGATTITC AAAGCGCTAA AAGTI'1GAAA TTT GACAGCG TTAGCGAATT AGAAAAGGAT FITGAACATG GAAGTAAC INFORMATION FOR SEQ ;D NO:318: SEQUENCE CHARACTERISTICS: LENGTH: 207 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO '00 06 (iv) ANTI-SENSE: NO 286 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .207 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:318 ATGAAAACAA TTAAAATGG TATI'ATGATC GGCACACTCG TGTTCTAGCT TTGATGCTCA GCGTITCGCT TGTCTCCCTA GCTTCTACCA AAAAAGAAGC GCAATACATT CCTAAGGGCT AACTTAAACC ATTGGGATTC TACAFTC' INFORMATION FOR SEQ ID NO:319: SEQUENCE CHARACTERISTICS: LENGTH: 570 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE:.
NAME/KEY: misc feature LOCATI ON .570 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:319 GTGCGTTGTT
ATTGAGCGGT
AAGACCATI'C
TTCAAAAGAC
TTTTTGACCC TTA'FrCTTCT p 0S Pb *9 p p. p p.
p p p p
P
ATGGAGC'ITA
ATTAAGTTTG
AGGGAGTTTG
AATAATTGcG
AAAGCTAAAA
GAGGTTTTAA
TIAGAGCGC
TTATGGCAAG
AGCTCAAGCA
CTAAAATTAG
TTI'ITAGGCTC
AACAAAAAGC
TCTATITGGc
CTATCGTGGT
ACAAGCGAGA
CTTGCTCTGC
G'FITAAAGGC
GAAGTGCGGG
AGAATrrAAG
GGG'ITAAACT
TCAATCCAGC
GCTCTAI'TT
GTGCAAGGGG
GGCTGATAGC
AGCCCTTGAA
ATTGATTTCT
G'TTrGATTGC
CTGTGTGCGT
CGTGGGGTrG TI'CAITA7TA
GCTAGGGCGA
GATGAAGAAA
AAATI'AGAAA
GTGGTGAGCG
TT1TAAAAC
CCTGTGTTGG
AGCGAAATAG
TTAGAGGACT
GGGCTGAATG
ATCTTTTAAA
GCCTAAAAAC
AAGCTAAAGA
TGGGTAATCG
GCCAAAATGG
AATGGCTGGA
AAAAATATTT
WTCATAAGCC
TGGAAGGCTT
AGAGCATGGG
CACAGACCCT
GTTAcI'GcG
CATGCAACGA
CAATGAAATA
TCTATCcGG'r
AGAGAGCGGT
TTATATTAAA
GITAGGGGCA
120 180 240 300 360 420 480 540 570 0".
00 INFORMATION FOR SEQ ID NO:320: i)SEQUENCE CHARACTERISTICS: LENGTH: 405 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (i)MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION (xi) SEQUENCE DESCRIPTION: SEQ ID NO:320
ATGCTTATTT
GATGCTATTC
TTGGAkATTAG
CACAAGATAG
TTIAAGGATA
AGCAAAATCT
AATCAAATAG
TAGGACACCC
ATTCCAGCGC
CCCAATAITG
AGACGGACAC
TTAAGCAAGC
TGTTTI'CTAT
ATGGTGTCAT
TTTAATCCCT
CAATAACGAT
CTGTGAAAAT
CTITTTITA
CATACTCGCC
GGATTITAAC
TTCTAAAGAT
AGCGCTCGTT
ATAGTGTGI'
GGCGTCCAT'
TTCAACGCTT
CAACAACACG
GATACAGAGT
TCACTCCTT
TTGTTTTvCAT
TTGAAGCAAA
TTAGCGTGAT
TCAAAcCGCT
CCACTAATTA
CATGGGAGAT
TGAAA
TAAAAACACC
CCCAAAAAAT
CTI'ITTATCG
CTATTGTATI'
CTTGTTAGAT
TTGCGCTAAA
120 180 240 300 360 405 INFORMATION FOR SEQ ID NO:321: SEQUENCE CHARACTERISTICS: LENGTH: 765 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-f eature LOCATION .765 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:321 fr 9. .9 9 9
ATGAAAAAAA
AAAATCTTAC
AAAAAAGCGG
GATTTAGAAA
GTGGAAGCGC
GCCAATAAAG
CCCATAGGCT
GGCTFIGAGCG
ATTTTAAGCC
CATI'TAGGCT
AAATTATTGA
ATTGAAGGCA
AGCATCAAAC
GATTGAATAT
AAGAAAATCA
TGGTGCGAGA
GCGTGATAGA
CTTATCTIT
CCATGTTAGC
TI'GAAGCGAG
CTAATCACAT
AGATGTTTAA
ATGCGGAATT
TT1'TAGCGTC F1'GAAAAGAT
TFFIAGGCAT
AGGGCTTGTG
AGAAATCATT
CGTGAAAAAA
AGATAAAGGG
AGCTAAAAAA
GTACCACCGC
CGTGTGTGGG
CCTTTCTITT
AAATCAAGCG
GAACCCTGAA
TTTAGCGTAT
AGAGCCAGAT
CGCTAAAAAA
GGITrAGGGT
AAAGACAGAG
CACAAGGGCT
ATTGATATrG
ACTFI'AGCCA
TATGAATTAG
GGTATCCCCA
AAAGGGAT
AGCTTTAAGG
TT1'GACATTA
GGCATTGATG
GACATGGAAT
CACCAGGGAT
GCGTGGGGAG
CCGGCGTGGA
ATGCTTTTGA
TCGTGGAGCT
AACAAAARGC
AACAAATCGC
TI'ATCAAGGC
TAAACGGCAC
ACGCTTTGAA
AGGGCATTGA
CGAAAITAGA
TTGCAAAAGA
TGCAT
CACGGTCGCT
AATTAAAATT
AATCAGTGAT
TATGGGTGGG
CTTCGTTACA
TAAAAACACC
TITAAAAGAC
G.AGCAATTIAC
AGACGCGCAG
TGCGGCGCAC
AGAAATCTTG
GTTTGGTTA.T
120 180 240 300 360 420 480 540 600 660 720 765 .9 4. 0 INFORMATION FOR SEQ ID NO:322: Wi SEQUENCE CHARACTERISTICS: LENGTH: 729 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 729 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:322
ATGCAAGAAA
GAAAGCGGCT
AAACTCATGC
AAITTTGTGTG
GACAAGGCGA
GCCGTGATGC
GAATCCATCG
GACGTGTTTG
GACAAGACCG
GACGCCAAAA
GATI'GTTAG
AAAGAGGGCA
CAGGGCTT
AACGACTTAA
TTATAGATGC
TCGCTTTGTT
CGATTGTGGA
CCATGCGCCG
TTGGGGATGT
CTCAAGCCCT
TGGGGGAATG
CCCATTTCAT
TGTATGCGGA
ACATCACTCA
AGACCACTCT
AGCCATTCAA
ATIGI-FCT
AGACGAAAAA
AATGATACAG
AAAGCTCCCT
GTTTTATTCT
CTCTAATGC-G
TTTTAATAGC_
AGAAGCGAGC
-TTGGG;TG
AGACGCCAAC
ACCCTACT'G
AACAAAATCG
AAGATTGGCC
ACAGACGCTA
ACCGCTTCTT
AGCATTAACG
AAAGCCITTr
GTTTTAAGGC
GACAAACAAA
TTAAAAAGCA
CATTTTGGCA
ACTCTAGGTA
CTTTTATATG
CTTCTTGGAT
CTTCAAAGAT
TTTI'ATTAGA
TATTGCATGA
CTCTTTTTGG
TI'GAGTTGTC
TCTCTAGGGG
AATACTGGCG
TGGCGATTCT
TGGCGT'I'ICA
AGCCCAATTT
AAAAATTGA-Z
CAAGGAAATI'
GCTGCGCTCC
TAAAGCGCTC
TGATGTGATr
GAATTTTAAC
TAAAATGGGC
CGAGATTGAA
TATTTTAGAA
T IAAATAAA
AATCATTGAT
TAGCGATTT
TCAGCATGAA
120 180 240 300 360 420 480 540 600 660 720
S
S
INFORMATION FOR SEQ ID NO:323: SEQUENCE CHARACTERISTICS: LENGTH: 756 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Heliccbacter pyloni (ix) FEATURE: NAME/KEY: .:r.-_eature LOCATION 1_7S6 (xi) SEQUENCE DESCRIP'7::2: SE2 ID NO:323
SS
S S 555 ATGT EmAGGGA
GCCCTTGATA
CTCTCTATGG
AAAACAGATA
CGCTCCGATG
'TIGTCTCAT
ATGCAGTATT
AGACAATTCG
AA&AGTCAAAA
GATACAATGG
GCTAGAGGTA
GACATTCAAA
AAAGAAGTGG
AAAAAAACGA
GATTGGCAAA
TGCTCAATGT
TATTTFGTTTA
CTAGGCAAAT
TGCTGTTI'GG
GCGATGTGAG
TAGATAAAGT
ATAGTCCCTT
AAAA'rrATGA
ACTCTTCTCA
TCACGGAT
AATCAAAAAA
AGA:;.
TG3CA=:.
CGTC~tA=::T
TTATL=AA-I
ITTTCCAAAC,
CCGAGCAGAA
AACGAGATTA
ATATATCACT
AGAAAATC=T
ACAAAACGAA
TAAGGCATTA
AT'TGATGAAA
GCCAATAGGA
ACGAGTATTG
CGATACACAG
GAAGCCGTTG
AATTCTGA
CAAGCAATGA
GCTATCATTA
ACATrTI'CA
AAAAAACAAG
ATCATCAACC
CAGACAGTAA
AATAAA
AITTTGGTTGG
CTTI'CAAAAG
TGATGATGAT
GAGAXI'TTAA
TGGATAGTGC
GGGATCGCAA
GAATGTTCAA
GCTCCAACAT
ITACCATCAA
TAACTATFI'A
CTTT'TGGCTI'
GCGAAATTT
GGGTGTGATA
GGCTI'TTAT
GCCTTTGAAG
AATCGTCAAA
AACTTCAAAA
GGATCAACTA
TGAAAATATC
ACAAAGAGAA
AATCACGCCT
'I'IATGAT Tr
CAAAGTGTT
GAGAAAGATT
INFORMATION FOR SEQ ID NO:324: SEQUENCE CHARACTERISTICS: LENGTH: 495 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .495 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:324 a a. a a ATGAGAGCGA TCGCTAT1'GT ATGATTGATT ITTCAATAA AAGCT'ITG AAAAAGTGTT AATTATGGGG CGAGTTT TT AC TTI'AGAAG TGATGGCCTA TGTTGTTTGT ATGGCGTTTC ACTTTAAAAC AAAATCAAAA CCTATCGTTC T TTI'AGCCTT CGCGCACGCA AGATC
TITAGCCAGA
ACCCATGCTC
TATCTCTAGC
GAATTTACGC
TCACATGAAA
AGTAT'T1'TA
TACGGATTAT
GAAAACGGCG
AGFI'CCAGTA
GCTTACCCTA
GATAGCATGG
CCTAAAAATT
GAATTAGAAT
CAAGAAAAGC
GTTTTCACAT
TCAAATGGC
AAAGGXFI'AA
TTGAAACAGC
AGTATGTCAA
TAGCAGACGA
TAAAAGATGA
ATTTACAAAA
GCTCTCCCTT
TTTTAAAGAG
GAATAAAAAT
ACTAAATTCC
TTTAGCCAAA
CAGGGCCACG
AGACATTGCG
CGCTTTTGAA
TAGCGCTTCG
CATTICAAACA
INFORMATION FOR SEQ ID NO:325: SEQUENCE CHARACTERISTICS: LENGTH: 513 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 513 (xi) SEQUENCE DESCRIPTION: SEQ ID, NO:325
ATGAGTAATC
TT1TGATAATA
AAATCCAACA
GTATITGATG
AAAAATATCT
GAACCCGGGC
GSSGCGGAAG
AAGCGAGCCA
AGGGGAATAC
TTAGCGCTAA
CGRATATI'G
TGCATGYCTT
TTCrAAT YTrCGAT1'C
TTTGGATAAT
CAAA ETCATC
TITAGC'I'IAC
TTTAGCGAAT
AAAAGGCGAA
CCCTGGGGAT
AT1'CTTAGAT
TITATGAACG
GCTATCACAA
TCTI'TATACA
TIAGATGTCA
GYCAAATTGY
AGCGGCGAAG
GAAGAGGGGG
CTAAAAATCC
GCGGTAAGGG
AGAAAGGTTA
ITTTGGGGT
AAGAAATCAT
AAAT=TAAA
TTCTAAGCGC
CAAAAGTI
GGGCGTGGGG
TAAGGTAGGG
GAAAACCCAY
'FrGCGAGATT
ATACATCAGC
TTTAAI'ITAT
ATI'TTAATTA ATACATTIC TAAAAATI'G GGTCCACTAT CTCAAACTTT TCTTAATIT CAGTCATTTC TTTTAI'T TATTCAATCT CCC INFORMATION FOR SEQ ID NO:326: SEQUENCE CHARACTERISTICS: LENGTH: 186 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .186 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:326 ATGCAGCATT TAGTCTTAAT CGGTTATG GGGAGCGGTA TTGGGGCTGG CTTTGAAA'IT AGAAGTGCTG GATACGGATA GGCTTGAGCG TGAGAGGGAT TTTTGAAGAG CTTGGCGAAG,
AAAATT
AAAGCTCTCT AGCACAAGAA TGATCATTAG CGAGAGGGTG ACAATTTCAG GATGTTTGAA 9 9 INFORMATION FOR SEQ ID NO:327: SEQUENCE CHARACTERISTICS: LENGTH: 654 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: risc-feature LOCATION .654 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:327
ATGAGCATTA
TTAGAAGGAG
ATCGTGGTGG
CAAACGAGAG
GCCTI'GCAAA
AGAGCGAGTG
ATCGTI'AAAG
GAAAAAACCC
GAAAATTCTA
AGGAAAATT
CGTrAGATT
CTTTTATCGC
AGCGGATCAC
AAAGATTGAA
AGAGGAACGA
CGTI'CGCCAA
CCATI'CTTAA
AAGACGCAAT
AGAGCAAGTT
AGAAAAGTT
TTATI'TAGGG
TCAAATTAT
AGAAGTCGCC
TGCAAACGAG
ATATI'CTTAC
AGAAATGAGC
CAAAAAAGCG
AGAAACGAAT
TTCAAACGCT
GATACAAAAT
AATGAAGTGC
CCAGAGrI'GT
TTTAAAAGGC
GCATCGCTCT
GCTFI'ACAAG
CATCAAAGTT
TAAAGCGA
ACAAGTGGGT
TACAAGAT'A,
TAGAGAGTCC
ATGACTI'GTA
TTTCGCAATC
CTAGAGATAA
AAGTGAACTI'
TATCAACTAT
TGAAAAGCTT
GTTGTTGTr
TAAGCATGAG
TAATAATATA
TCAGTTCGCC
TI'CTAATGAA
AAACCTGCTT
GTTGTATGAA
CCCTCTAAGT
TCTTCAC-1CT ATGCTATAAT CTCTGTTI'A AAACATTATG GAATGTTAGA AGATATTCAG CAAAACCCTT CCAAACCAAC CAATCTAAAG AAAGAAACCA TTCAAGGAAC GCAT INFORMATION FOR SEQ ID NO:328: SEQUENCE CHARACTERISTICS: LENGTH: 303 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .303 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:328
GTGCATI'TCA
GGGCCCGGGA
GCCATAGAGC
GCGATGGGTG
GATTTATTCG
ATCAGGTTGT
G-CGC'FrTAAG
AAGAAAGCTC
GGGGGAGAAT
GCGAGCAAGC
TCTCCCAAAA
AGAAGAATAC
AATICATAAC
GGGGGTTTTA
GGTCTTGTGC
GGCGTGGGCG
CTrAAAAATA
GCTAAAGCGG
GAAACGAGTT
GGGGGGTTAG
CGATFFI'AGT
GGGGTITATA
TGGCTTTAAG
TTAAAGAAGA
AAGTCGATCG
CGCACCAAAA
CCATCTAATC
CTATGCTAAA
ATGCGAGAGC
TAAGAATGGG
a INFORMATION FOR SEQ ID NO:329: SEQUENCE CHARACTERISTICS: LENGTH: 240 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: ci rcular (ii) MOLECULE TYPE: DNA (=enomic) (iii) HYPOTHETICAL-:I.: (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE7 ORGANISM: Hc::zcnater pyloni (ix) FEATURE: NAME/KEY: miz_ :eature LOCATION !..-24C (xi) SEQUENCE DESCRIPTICN: SEQ ID NO:329 ATGAAAAAAT T11'ITTCTCA ATCTIGTI'A GCTCTTAFI'A TCTCTATGAA GGCATGGATG GTA.ATGGCGT TTFTAGGG GCGGG'ITATT TGCAAGGACA CATGCGGATA TrAATTCTCA AAAACAAGCC ACCAACGCTA CGATCAAAGG CTCTIGGG0T ATCAATT CTFI'GAAAAA CACTTTGGCT TAcGcc=A
TGCGGTATCT
GGCGCAAATG
CTFI'GACGCG
TGGGGTTT
INFORMATION FOR'SEQ ID NO:330: SEQUENCE CHARACTERISTICS: LENGTH: 1341 base pairs TYPE: nucleic acid STRANDEDNESs: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1341 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:330 ATGCTAA Akk
GCCGTTCTTG
TATCGCCCCA
TATGATAAGG
AGCCT-TCTAG
GTCATGCGCG
CTAACCCAAC
CTCAAAGAAG
GAGCGTTATr
TTAGGGTATT
GCCTTACCTA
AGGGCTAATG
AAATCCGCTC
CCCTATGTCG
GGCTATACCA
CG'rITrGGGC
TCTAATGATA
GGTAAGArT
ACGCAAGCCA
GATAATGGCT
AATTATAGTA
TTTTTAGGGC
AATTITAGCGA
AGATTTTTTA
TCGCTCAAGT
GTGTCGCTTC
AATTTCGOT
CGGTAGAAGA
CTATGATI'AA
AACTCGTTAA
CTATCATCTC
TGAACCAAAC
TTAAAAAACC
GGGCTCCAAG
ATATTTITAAG
TCAATGAAGT
TGGATGAAGT
TAAAACTCAC
ATCAAAAAAT
AAGATGAAGA,
TAGCCTTAGT
AACGGCAGTr
ATTCCACCAC
AAAACAGCGT
TI'GTAACCTT
TCGCTTGGCT
TGGTTTrrATc
TTGGGTAACT
ACAGATTT1'A
TTATGCGCGT
CACCCTCTTT
AAACGCTAAA
AAACATGGTG
CATACGCATT
TTITTTI'GGG
CCTI'GACAAA
TTITTTATGAC
GCGGTTGTAT
GCCAATCGTC
GTGAAGCAA
GATAGATI'G
CTTAGAAAA
CAACTTAAAC
GGGGGGGATT
TGGGAGCGCR
LTCCAAAATc
GCAA.AACCAC
GCAAGAAGCC
A
GTT~rTT~rT1
ACGGATAAGG
GACAGAAAAG
TTTGAAGAAA
TI'TGAGCATG
AGTGGTCGTT
CTCACACGGG
GAAAAAGTCT
CATGGGTATT
CTCACGCTTA
CCTACCAAA
TCITTrAGGcy
TATAACCAAA
TTGGATCAAT
GATTACCAAc
ATCGCTAAAG
GCCAGCATGA
GATTATAAAA:
ATCAAGCCTT
CCTGATACCG
GCATGGCACC
T1TGAGCCATT
TGATTATCGT
ATATTGCTAA.
GGCGTTTGAT
TCCCCCCACG
GGGGGATCAA
ACACTGAAGG
AAAAAACCCT
TAAGCA.AAGA
ATGGCGTGAA
AAGAAATCAC
ATTTAGATT
GGA'TrCTTC C'FrCCACGCA TAGACGGGTr
GCTTAGCGI'
AGAAGCCAAA
TAGTTACAGA
AAAGCGCTTT'
TTGTGTATCA
CGCGAAATTT'
CTAGCAATTA
CGTTAAATCT
AGGGTTGTTG
AAI'PJAAGAT
CGCTAATATT
ATITGTTGAA
TTTAGACGCT
GGGTAGCACT
AACCAGAAAA
AGAAATTA
AACCGCAAGT
CATGTTAGTC
TTCACTCTCT
TAACGAGCTC
AAATATCGCT
AAAAACTCAA
GGAGTCTTTG
AACTAACGCT
AACGAGCACC
CAATCGCGCC
AATCGCrTT TGAAA6ATGGC
TRCTCGCAAA
GGCTACGATT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1341 INFORMATION FOR SEQ ID NO:331: SEQUENCE CHARACTERISTICS: LENGTH: 654 base pairs TYPE: nucleic acid STRANDEDNEgS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .6S4 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:331 ATGAACGATA CAACAGAGCA CCATGGATCC
TCACAGAGCA
GAACAAAGAT
ATAGAAAAGC
CAGAGAATAA
CTGTTAGGAT
AGAACTAGCA
ITrTACTATG
ATTTATGAAC
AAAAACATTT
ATAAAAAATT
ACGATCTCTT
TTCACGAAGC
TACCGCAAGA
TGGAAGCATA
TGTGTATGGG
AAAACACAGA
CCITTTGGTGT
TATATATCTI'
GCTTCATAGG
TTATCAATGG
AAATITTGCTA
TTTAAAGAAT
AAAAAGGTAT
CGCTCATTCA
TGGGATATT
GCTAGTGGAA
GGGTGCGGTT
AGGAATTGGT
TATGGGCTAT
TCTTTTCGCT
AATCCGCTAA
GACTCGTTAT
CAAGAAGAGT
GAACFI'CTGA
TTCTTAGGAT
GTTTTGTTTG
AGTCTAAAA
TTGTTF.L"I-.TT.1G
AGCACTAACG
TTGATTTATA
TCAAAGAAAC
ACGCCCCACC
ATCCTAAAGG
TGAAAAATAT
TGCAGATAGG
ATATAGGGGG
CAATCTATT
CAA.AATrAAA
GATTAGAAAC
ACAAGGTGCT
AAGTTATTA
AAGGCGGTGC
ACCTAGCAAC
GAGTTAGG
CCTAATAGA
ACAAGCCAA
ACTAGAGCAT
TGTATTTTTA
ACTTCAGTAT
AAkTTAGATCG
CTTI'GTTTTG
AGTTATTGGT
AGAA
a a INFORMATION FOR SEQ ID NO:332: SEQUENCE CHARACTERISTICS: LENGTH: 576 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc feature LOCATION .576 jxi) SEQUENCE DESCRIPTION: SEQ ID NO:332 a.
a a.
a a
ATGATGGATA
GATGGGCGTT
GACACTITGA
GGGCATTTTA
CTTG'ITTG
CAAACGCCAG
GCCATGCCTr
GCGAGT'FTAA
AAAGCGITCC
TTAGAACGCC
AGGTGGGTT
TGAACGCGTA
TCTCTAAAGT
AAAATAAGGA
CTTTGATCGC
CGAGTTTGAT
TGATI'GGG'TT
GCTCTAAAGA
CCTATI'CGCA
TAAAAGCTT
TAAATCTCAJA
TITTGGAGGC
TGGGACAGAA~
TTTGTI'GAAA
TCATTTGCCG
CACGATTCTA
TTTTAGCCGC
GACTTI'AGCC
CCC'rFITTAT
GGATI'ATGAA
GGCATCTTTG
TTGGGTAAAA
SGGCTTITAG
AATTI'AGGGA
CCGTTGGTT
CTCTTGTrr
AAGAACGAAT
AAAGCGTTAG
GTTTTCTTGC
ATTGA
TGATGGACGC
ACAAGCGGGT
CCATTITAGG
T27ATGGGAGG
TTGAAGGCTT
TGCCGGTGT
ACAATGCGGA
TGTCCATTGT
ATTTCACGC.A
TAGCAAGAGG
GGTGTTGTrT
GCATGAGTTA
CITGCTCGCT
TAATGTCTCG
'ITCCTTTTAC
CA.AGTTTGGG
GAATGAAAAT
CCCGCCGCTA
INFORMATION FOR SEQ ID NO:333: SEQUENCE CHARACTERISTICS: LENGTH: 603 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .603 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:333
ATGAATATTT
AAGCTCAAAG
AATTTCAACC
TCAAGCTrAG
TITGGCTTGG
TTIGGTGGTCA
TCCACTGAGA
ATGATIGCrr
TTAAAACTTT
CATTTCACGC
TCA
ATCAAAAAAA
CCATTAAAGA
TCTI'AGATAA
AGCTATATAA
GTAATGGGGT
TTGAGCCTGA
TTFI'AGAAAA
CATTATTTGA
TTAACGCTIA
GCGCTTTAGA
CTTGCAAGCT
AAACAAAAAA
AGAAACAAAC
AAATAGCGAA
GTTTTATCGC
AATAGAGGTG
TCGTTTGATT
TATGGATAAA
TTATGAACGA
GCATGGCGCT
CTTT1'CAAAA
TACGAAGTGT
ACGCCCTTAT
ATI'CACATGC
TTGCTTITAG
ATITTCATTG
WI'ATTGCATG
AAGTCTCGT
TACTCTCATC
ATTAGCGTAG
AAGACCCTCT
TTTI'AGGGAA
TTGAAAAAAG
TCTATCCT'A
GCAATGAAAA
TGCTGAATCT
CAAGTITTTTG
TATACGCAAG
AAATGATAGA
GCAATGACGC
TTGTTCGCA
TGATAGCGCG
CCCGCTAGAT
TTI'GTATTAT
T ITAAAACGC
TTITGGATTTT
CAATI'ACAAC
AATGTATGAT
AATCAACCAG
TAAAGCGCAC
*5 5 0 *0p5 0~ 5* 5 *505 .5 S S
S
INFORMATION FOR SEQ ID NO:334: (iJ) SEQUENCE CHARACTERISTICS: LENGTH: 390 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .390 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:334 St *b.r 5*5S .5.5
S.
S 5 4
ATGAAAAAGA
CCTAAGTGGT
AGTGGTTCAG
TCTATTAGCG
TTAAAATCCA
GTAGAAATTG
TCAAAACTTG
TTATrrCTTGC
ATAGCAAGGC
CCACT1'CTAA
TGGTGGTCAA
GCGAI'CACA
TCAATCAAGA
TTTTTGCAGG
ATGCCTTGTG
CTATAACAAA
AGAGGCTTCT
ITCACAAATC
AACGATCAAC
AGCGCAAAAA
GITTTAAGGGA
GCTrTGTGG
ACAAACCCCC
AAACAAAAAG
CACATTCAAA
TI'AAAAACCG
GGGATCTACT
GTOCCAATTT
AAAAAGGCTA
CGITAGCGGA
AAAGTCGTGT
ATGAC'ITGGA
ACACCAGAGT
AAGCGCAGAG
TCTTTATGGG,
TITAGTGGCG
GGATAATAAG
ATTGAATAAT
GAGGAATCAA
INFORMATION FOR SEQ ID NO:335: SEQUENCE CHARACTERISTICS: LENGTH: 432 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .432 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:335
ATGAAAATCC
ATTGTTGGCA
ATGATCGCTG
TI'CACTAACA
AACGGGCTTGr-
AATAAATTTA
GGGTTRGSCA
GCTTTAGGAT
AAACAATT'C
AAATTTCACC
'TTI'AGACTC
GCCCAACAGA
TCAA'ITCTAA
AAAACAAAGC
ATGGATATGG
cc
AACACTTGTC
CCACAAAACC
CCAATCTTGG
TTGCGATAAT
AGTCGATCAA
RGATCTTGAT
CAATGATGGT
CTTACAATAA
GCAGAAGAAT
GGCGATGCGA
GATCCTTCAA
AAATATGTGT
GTAAITGT'I'T
GAATATGGCA
TAATGGTAAT
TCACYAAF1'T
TCTTAAACGC
AATGCGTAAA
TAAkACAAACA
TAAAGGATTC
CATTAGGGOT
ACAAAAAATG
AATGTrGAAC
TCCTTTTGAG
TCCTGGGACA
AGACATTGTC
AGGGOTTGTA
AGWAGCCTAT
t INFORMATION FOR SEQ ID NO:336: SEQUENCE CHARACTERISTICS: LENGTH: 927 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .927 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:336
GTGGTAATAA
TATCTTGTCT
ACGCTG'FrAG
A'TTTGTCT
CTCTIATCCA
ATCCTI'ATCA
ATCACTGT
AGCATTGCTG
GAAATCTCTG
'ITGCATGACG
A.ATAGCAATA
GATAT1'GAAC
AAAAACATGC
ATTAGGGFI-r
CGCATCAAAA
TCTATCAACA
GGTI'AGTCCT
CTGTTAGCGA
TGGATI"Ir=
TTI'GTATAGG
AAAAGGATGA
TTACTACAAT
TAGGAACGGT
GAGGGATAAT
GCCTAGAGGG
GGCGCTTGGC
ACACTGCGTG
TGGTGCATAA
CCACTCAT
GGGCAAAGAT
ACGCCCTGGA
AACAAGACTC
AAACATGCTA
TnT" GTGATT
CCCGCAGGCA
TTTTTATTT
GATTTTGGCG
CATCfGCGCTC
GGGGATI'GCG
CCTTA'ITATT
CAAAGTAGAA
GGTTTTGCCT
TCGGCGCATT
GACTATAAAA
TGGAATCACG
TGAAGACGGG
CGCTAATCGT
TTCTAAG
ACATGTCAAA
TGCAAGGAAA
AAGCATTTTIG
TCG7I7 ICT
AAT'TITGTCG
AGCACGCTAG
GTGGCGTI'GG
TIACACCCTT
GCGCTTAATT
AATAGAAGTG
GAATGGGTCT
GATGTTATTG
GATITTTGGAC
ATCITTAATG
ATTGAAATCC
TTAGCTATAT
GATITATGGA
GGATAATCT
TACGGAACAA
CGCAGGrI'AC
GCGTCCAAAC
CTFI'AAAAGA
TCAAAAAAGG
TTTAATAC
TCGCTAAITC
GTGGGGTAGG
ACGGGATGGA
AAAGTI'CGCT
TGAGGAGCGA
CTTCAACAA
AAGGATAAGT
TGAAATTAAA
AATCAAGGCT
AACCATGAAA
TTITTATCTTA
CACCTCTATT
TTATCTrCA
AGACATCATT
TTCTTTrACGC TAATArI'ATC
GTATGGGAGC
AAAAATI'GAT
GAACTTCACC
ACTCATTGAA
GCTAGATATT1 120 180 240 300 360 420 480 540 600 660 720 780 840 900 927 INFORMATION FOR SEQ ID NO:337: fi) SEQUENCE CHARACTERISTICS: LENGTH: 491 base pairs TYPE: nucleic acid STRAN~DEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .491 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:337 0 0 00*o 0* ATGkAAAACT
CTGAGTCTGC
GGCACGCITr~
AACCCGGCTA
ACCACCACCG
TI'ATATTCGG
AACACTATAG
TTATCACAAG
ACCCTCGCIT
TI'TCCCCACT
CCTTGCI'TC
TAGGCTCGGC
ACATGGGCTI'
TGATCAATAT
TAACAAGTIT
GGTI'AGGCAA
CTATCAATCG
CTATTGTCTT
TTATGCGAAT
GTATGTCGCT
TACTAACGAT
CCCGACC'TI'
AGAAATTGAT
TATCCTTAAA
TGTTCAAGGG
AAAARGCTCA
GGCTTTAAAA
GGGGCTAGGG
TGGGGCGAAA
AGCTTTAAAG
AAAAGCCAAC
GCGCTTGGCA
CTTATGAACT
AAAAACrGCCA
TCCAAGAGCA
GTGCTGACGC
ACAGAAGCGA
TCCCTACGAC
AAAATATTTT
ATACGGC-CGC
TAACCAATCA
TTAATCGCT
AAGCTTGAAT
TTCTTTTTAC
ATTTGA;LDTG
CAATCAAGRC
AGGCATCATC
TACCAATGGC
AAAAGTCGTA
INFORMATION FOR SEQ ID NO:338: SEQUENCE CHARACTERISTICS: LENGTH: 162 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE:- NAME/KEY: misc-feature LOCATION .162 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:338 ATGTG'TTTAG CGATCCCCTC TAAAGTCATA GCCXI'TAACG ATAATGTGGC ACTCTTAGAG ACTITGGGCG F1'CAAAGAGA AGCGAGCTTG GATTI'AATGG GCGAGTCCGT TAAAGTG;GGC GATTATGTGC TACTACACAT CGGCTATGTG ATGAGTAAAG AT INFORMATION FOR SEQ ID NO:339: SEQUENCE CHARACTERISTICS: LENGTH: 606 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geflomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc -feature LOCATION l...606 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:339 ATGAAATA'rr
CTAGATATTA
AACGATGCCA
CAGCATTTG
GATAAAAAAG
TCACGATTAA
ATTGTAAGTT
TATTTAAAAG
GGACCAGGAA
ATCAAAAACA
TATTAC
TATGGCTTTI'
TTAAAACCAT
ATTACGCTTT
ATGTTTCTCA
TCCATCTTGT
AACTTTATGA
TAGATCTATA
CCCCTTCTAT
TCACAAACAT
ACCGACTCAA
TTTAATATAC
TCAAAAACTT
AAAATTGCAT
AAACAAAGAG
AGCGCTTGTG
TGTGGATACA
CCCrTrGCA
CGCTTGGATG
CGCACTAGCG
TATTTTCCCC
GCTATAGGGC
CCTAAGATTG
GAAGTCTTAG
CAAGGTGCTA
AGCGTGGCGG
GGAACGCTCA
GCGCACAACA
AAGCGCCTGA
AATTATACGA
AAATGGGCGA
TFI'TGCAAC
AAGTGCGCTA
CGAACGATTT
TCAATTACGC
TAGAAAACGG
AAAAGACTT
TGGCCATTGT
TTGTTFrTTTC
TGCGTTATCA
ACGCTGAGCA
AGATAAAACG
CTCCATAGAT
AAAGACTAGC
AGAACTCAAG
CAATAAAATT
TGACTACCCC
GGTGAATGAT
TAAATACATTI
AAAAGAAATC
AACGGAr-TT 120 180 240 300 360 420 480 540 600 606 INFORMATION FOR SEQ ID NO:340: SEQUENCE CHARACTERISTICS: LENGTH: 615 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genozuic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO ivi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1.7.615 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:340
GTGGTGAGCG
TTAGAGGGCA
TI'AGTTCTAT
CATAGCGAAA
ITTGTGCATA
TCTFI'AT~CC
TTGAGCGTGG
ATTGAAAGCG
AGCGATGAAT
GGGTGGTGAT
AGATGTTTAG
CCATCACTAT
CCTTTTTAAC
ACCCTAAAAA
CITrTGTGGG AAACCAcccc CGATTAAAAAj
TGGGGCTGGA
CATTATTGTG
GCCITTAGCG
CATTCCTGTA.
GAGGTTrA AGTGATTrA GAAGAATTrc
CTCTATITCC
GCATGTCAAA
TTTAGGGGGT
TITI'TTGTGC
CAAAGCATTG
GTGAGCTCTC
AACAGAATCT
GGAGCGTTrG
ATGCCTGCT
TTAGATCAAT
GAAGTTAAAA
'ITGAATCAAA
CGATTCTAAC
TGTATGCGCT
TTGTC1-rAAA
ACGCCCCTTT
TFTrFI'TAAT
TAGATGAGGG
CTAAAGATCT
GCATTGTCGC
CCGATACTIT
CTTACAGGGG
TTTAGGCACT
AGCCACCCCC
ATTGGATTT
CGCAAGCCTT
CGATGTGGTT
CATGTTAAAC
GCGCACAGGG
TATITTrITC 298 ATCCCTAAAA AAGAATGGAG CGTTAAAACC AAAGATGAAT TGGTTAGAAA AAATCATGGA 600 TTCTTTAAA GACTT 615 INFORMATION FOR SEQ ID NO:341: SEQUENCE CHARACTERISTICS: LENGTH: 216 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...216 S (xi) SEQUENCE DESCRIPTION: SEQ ID NO:341 GTGGGATATA TCCCTARGGA AAAGATTGTA GGCATTAGCG CGATCGCTAA ACTCATTGAA ATTTATAGCA AACGCCTGCA AATCCAAGAA AGGCTGACCA CTCAAATTGC AGAAACTTTT 120 GATGAAATCA TAGAGCCAAG GGGCGTGATC GTGGTTTGTG AAGCCAAGCC ACTTGTGCAT 180 GAGCATGCAA GGGGTGCAAA AGCAAAATGC GATCAT 216 INFORMATION FOR SEQ ID NO:342: SEQUENCE CHARACTERISTICS: LENGTH: 39 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...39 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:342 GTGGCTCTTG TGTTTGATAG TTTGATAGAG AACAAGAAG 39 INFORMATION FOR SEQ ID NO:343: SEQUENCE CHARACTERISTICS: LENGTH: 297 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: 1Helicobacter pylori (ix) FEATURE: NAME/KEY; misc-feature LOCATION .297 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:343
ATGAAAAAAA
GAAGTGAGCG
ATGAAAATCA
GCAAGAGAGG
TATTCTTTAG_
TTGGITTGAG
CTGAAGAGAT
ACCACACGAA
ArI'TAGAGGT
GGGGCGTGGT
CTTGTGTTTG
TGCGGATATT
GGGGTTTTGC
GCCACTACTC
CGATTGGACG
GTTTTGAGTT
TTCTACAAAC
GCTAAAGGCG
AATGAAAAAG
ATAAAAGCAA
TGGG-TTTTT
TCAAcc,
TGTICCTCCC
AAATCCCTC
GGTTAGGGGA
AAAAGCCCAT
AGAGCCTAA
TAACCCGCAA
GTCTGTAAGG
ATGGCGT
120 180 240 297 a a INFORMATION FOR SEQ ID NO:344: SEQUENCE CHARACTERISTICS: LENGTH: 300 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylonl (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .300 (Xi) SEQUENCE DESCRIPTION: SEQ ID NO:344 a.
a a a GTGATcAA~c
GGGTATGAAC
TTAAATT1YCC
AATTTGAGCG
CAAAAAACTT
CTCATAGCGT GGGAITGGTA TGCAGGTACG CACCCGTAGC CTGGCACGGT GGATAATGAT ATAAAGATI'T TAAAGTTCAA ATAAAGCCGA AITTATAGAA
AGGATTGGGA
GGCTTGGCTT
TATAGGGGCG
GTAGGGGATA
TGCGAACAAT
TTTGTTTGTC
TGAATCATCA
AAATITAAGGT
GGATCGCTCA
TAGATGAAAC
TTTAGAAGTG
GGTGATGGTG
CATTTrAGcG AGGGGTGGTr
CTTCAAGGGG
120 180 240 300 INFORMATION FOR SEQ ID NO:34S: WI SEQUENCE CHARACTERISTICS: LENGTH: 765 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .765 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:345
ATGGAAATCA
AAAGAATATT
AATGACCCCT
GGCGCGTATA.
TAAGAACGC
GCCAAAGAGC
GAAATCGCCG
ATGCTATTAG
GTGGGGG CGT
CA'CTTCAATT
CAAACCCACA
TACCATAAAA
ATCGCCCTCG
TTATTAAT
TGAAAAACCC
XITGCTGGT
TGCGTCTrT
T"I'ATCCA
TTCTCAATGA.
ACCACACGCA
CCTATGCTGA
T7WIGCAGAT
CAATAGAAAT
CCACCATGCA
TGAATGACAA
CT1'CCCAACT
TGTGCGGCG
CCTAAACCCT
GCAATCTAGC
AAAATTITA
TGAATTGGAG
GCCSGTGGAT
TGGAGAATAC
TGGGA7rTG
AGACAATCAA
CCCTATGTCT
AGATI'TAGAA
CAAACGCTAC
TITTAGAAAAT
GITGTGTTGT
AAAACCAAAA.
CCCCTAGACA
GACATTCAAA
CAGCCCTTAA
AAAAAAGAAA
ACCAAACGCC
GACAGCAAAG
GATITIAACG
TTAGAAGAAG
AAAAAAGCTT
AGCGA.ACAAG
GA'FITAAAAG
T=ATT'ITTA
CCGAAGAATA
AATI'CAAGCA
AAAACGCCTT
ACAGCGAACA
ATTTTGAATC
TGAAATTAGT
AAAAAGAATT
AGCTT TATGA
CAAAAAATCT
TGGATTTAAG
AT=ATCTC
ACTCA
CAACACCCTC
CGACTTGAA.A
AACCCAAATA
GGATAACGCT
GCAAAATI'TA
CTTATGCCAA
GGAATTTCT
GTT1TTTAGAT
CAATT=GAA
TITI'GAAATC
CGC CCC CTAT
TTTGAAAAAA
120 180 240 300 360 420 480 540 600 660 720 765 INFORMATION FOR SEQ ID NO:346: SEQUENCE CHARACTERISTICS: LENGTH: 318 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAMEIKEY: misc-feature LOCATION .318 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:346
ATGGAAGTAG
GTCATTAAAA
TTAATTITCTC
GATFAGCCA
GTCGTGATCA
TI'GAGAAAGA
AGCATGGCAA
TGATGCTTTr
TAATAGGCTA
TTAGGATTGG
TCGTITTAGT
ATAAGTAT
GATTGAAACC
AGAGAGCCTG
TICGGCTAWG
CTATCAAAGT
GCAAATCATT
ACTrI'AAGCT CCTrCTTrAG
GCYGGAGCGT
TATAGGGGCG
CAAAGCGCGG
TGGGGGCGTC
TGAATAATAT
TAGGGGCTGG
ATGTGC TIT
GGGATTATGT
TCATTTGGAA
CACCATCACT
GGGATTGGGG
TTATGCGGTG
GGTGAAACGC
120 180 240 300 318 INFORMATION FOR SEQ ID NO:347: SEQUENCE CHARACTERISTICS: LENGTH. 1581 base pairs TYPE: nucleic acid sTRANDEDNEss: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 1581.
(xi) SEQUENCE DESCRIPTION: SEQ ID NO:347 0*eS 0*
ATGAACGAAA
AAAGTTAAAA
AAAATTGAAA
GOTGAGCCTT
GATGAGGCGA
ATTGAAACGA
AAAATCACTGS
GTTTCAGCCC
GTGGTAAAGA
AAGCAGGTGC
GGCATGTCTT
GAGTATAAAA
AACGCTT= G
TTTAAACTCG
GGGGCGGTTA
CCGATTGATT
CGrTTAAAG AT'FrTTGATG;
GCGGAGTATG
CATCATGAGG
GACCCTAAGG
TTTTCGCCCC
TACATGGTGC
GCCTITACTCA
GTAATACCTC
CGCATCCAAA
GCGACTTITT
TTGACAAATC
CCCCAAAGGG
ACGCCCTAAA
ATATTGTCCA
TGGTGTGCGC
TTGAGCGAGA
AAATCAGGAA
TCAC ITTTrAG
TTAGCGACAG
GTATTrCTAA
CAATCAAAAA
ATATTAAGGA
CGAGCAAGTT
TTACAAGGGT
ATATTGATGA
GCTACAAGGT
ATTACATCGC
AATCTTCTGT
GTAATTCAGC
GCATGCGGTG
AAI'FrACGA
ATGGGGACAC
ATAGTGArrT
ATCAAGAATT
GTTI'CA'TTG
GAAGAAACCG
TTTGGGCGCT
CGITGATATC
TGGTATITGAG
ITTAGCGACC
TCCTATTI'GC
CGCGCTT'rTG
ATTTGGGCAA
AGAAGAGTTA
AAAGATCC'Fr
GTTGCACAAC
AGAAACTCTA
CGAAT1'AGAA GTATTrGCAC
AGAAAAAAAG
GAAACGCCCT
AAITTTGGAC
TTTAGGGAT
TIGCCCAAA
TTATGAAGTG
CCATTGGAAG
GTI'GCAAAAT
ACTCGCTAAG
TTACACTTTA
GGGCGATAAA
AAGGAGTGGG
GATGGATCAG
CTTGAAAGAA
GGATTCTTAC
GT ITTAAGGA
AAAAGCCATA
GTGGCGAGCG
CATGATGTGG
GATGTGGCTA
GGCGTGAGTT
ATTAGCGCGA
ATGCTCACCT
GCGGTGTATG
GACAAGAGCT
AAAAACAAAC
CTTTTTGACA
TATTCTATTT
TTGTTAGCCA.
ATTCATTTGA
GAAAATGGCT
CAGATCCGCA
TATAAAGCCG
TITAAATACC
AACGATTTGT
CCGGTGGGCG
GCCACGGACG
GATGTGGTTA
CTI'AAAACTT
AI'GACACTA
GGATTCTGGA.
CITTAATTGA
AGGGGCAATA
TGGTGGCGTT
TAGAAGACAC
ATTTAGTGGA
CTCAAGATCC
TACAAGATCC
TAGACGCCTT
CCCCCATAGC
TTTATTATAT
AGTCTTTACT
GCGGGTTTAG
ATCTTAAGAT
TI'AGGATTTT
ATTTCAAACC
ATAAGACAAT
CTITl'GATAT
GGGGCGTGGA
ATGACAGCGA
ATCGTGAAGA
CGATCGCTITT
CTTATATCAA
AAATCATTAA
CTAAGGCTAA
AGAGCATGAT
TGTTATTAAA
T1'TCACGCCC
CAGAAAGAGC
TTGTGGGGGC
GCCI'GTGAG
TGCGCTCACC
CAGAATGGTG
AAGAGCCTTA
GCCTCATGAC
GAGTCGATTG
TTATCCAGAA
CIWAAAACTC
CCATTCGGAT
GCAACGAAAA
ATTGAAAAAC
CATTGTTTCT
ACACACGACG
GCACATGGGG
TCATGAAGAA
TI'TGAAAAAC
TATTGTCGTT
AGATTTCGCT
TAGTAAAAAA
AGGCGATAAA
AXACCATTTG
CAATATCTTA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1581 INFORMATION FOR SEQ ID NO:348: SEQUENCE CHARACTERISTICS: LENGTH: 372 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .372 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:348 GTGGTGGTGrG
GGTATTCCAA
ATCGCTAAGA
TI'AGAGCAGG
CTFI'TAGAAC
GAAGTCATGC
TGCGGGGGCC
TTGAGAATAT
TCATAGAAGT
ATGTGCCAAA
CTCAAAATAG
ACGCAAAGAA
AAGCTTTAGA
GT
AAAAGACGCT
AAC'FrTGCGA
AATGCGCGTG
GGGGGCAGAG
AAAAGACATG
ATTGGGTTAT
GTGCCTIAG
TCAAACTGTG
GGTGCTGGCA
TTTTIGATTA
CCTTTAATAC
AACGCTFI'GA
CGCAAAGCCT
CTTTAGAGGC
CGATACTCAA
GCCCGGGTCT
CTGGGGTTTC
AA''T1'TCCC
RATARAGGGG
CATAGAGCTT
TCTCACTCAA
TACGATAXAG
TAGCAGCAGT
GGCGGAGTAT
120 180 240 300 360 372 INFORMATION FOR SEQ ID NO:349: SEQUENCE CHARACTERISTICS: LENGTH: 330 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .330 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:349
S*
a a. a a.
a. a
GTGGAAAAAA
GITAGAAACG
TGGGAAAGCT
ATTTTAACCG
CTI'AAGCCTA
GATASCTI1'A
TCAXACCCTA
TCCAATCCAC
T1'GAAACGAA
CTAAGCATITT
TTAACCATCG
ATGGGAA=F'
TGCCCCTAAA
TTTAAAAGGC
GGTTTAGGG
AGGCTTAGAG
?I'TGCAACTG
AAAGGGCATG
GATAGCCCT1' ACTrCTI-rrG
GAGTI'TAACG
ACAGAAAGGA
TI'GGAAGCGA,
TAATAGACTA
AAACGC'ITAT
CCTATAATAT
TCAAACGGCT
ATCAAAAAAT
TTCTAGCCTA
CAATGGCGT'
CGCTrCAGCG
TGITTTGAG
CATTATAGAC
INFORMATION FOR SEQ ID NO:350: SEQUENCE CHARACTERISTICS: LENGTH: 1791 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc_feature LOCATION .1791 (xi) SEQUENCE DESCRIPTION: SEQ ID
ATGTCTAATC
CACTCTTTGT
GCTTTGGATA
ACGCCTAGC-A
GGTATAGGCA
ACGAAGAGTT
CAATTTGGCG
AAAAAAGTTA
ATCAGCGAAT
GATTCTCAT
ATCCCTTTCC
AAAAAAGAAG
ATGAATAAGA
GATAACAGCG
ACGCTTT
GGGGTCAAAC
TCTTATTTGA
CGTGAAATCT
ATT=TAAGCG
CCTTTTGGGA
TTAGAATTGT
AAAGAAAATT
TTATTAAAAG
TTGAGCGATG
T'TTAGAGACG
GAGGTAAAAG
ATTAAGGGCG
CCAA.ATGCGA
AAAACTTTAG
AAAGAGCAGT
AAGAATACAC
ATFICTAATAA
AGCTGAATTA
TCCA'TIGAG
TGGATAAAAG
TTT1TAAGCGC
TGGGCTI'TA
CCAGTCATCA
GCGTCAAAGA
TTGCGAGCCG
CTATTTTT
TTAAAGAAGA
GCGAATTGAA
AGCCTTTGAG
ATATCCCTAG
TTATG'ITAA
GGITTGTTAA
TACAGCAGAA
AGATTGAAAG
AAGTGTTAAA
TGAGATTCTA
TAAAAGAAAA
CGTCCCCCCT
AAATTGATGC
CTAGCCATAG
ATCAGTITAA
TAGAGCTTTC
TGATGGCTAA
AATTAAACCC
TGAGCGCT
CTTCCAAACT
AGAGATTFFI'
TTTGATGCTA
TTTTGATAGC
CGATCTCATC
TTTGAGTGGG
TTCGGCGITC
AGCTTATGCA
GGAGCAAGGC
TTGGGAGATT
AACTTACACC
AAAATGCGAT
AGAAAAGGAT
CTATATCCAT
CAAAGCGCCC
ACGGGTGTT
AGGCGTGATT
TAAGATI'TTA
GCTGAGCAAG
AGAAGGCTTG
T1'CTAAAGAC
TCAAAAAAGC
TTTAGAAAAA
GTTTGTC-ATG
TGAGAGTTTG
AGATT1'AATC
TGGTCATCTC
TI'GGATGCGT
TAACCATGCG
TATCTGGTTG
GAAATCAACC
TTAAGGGAGT
ACCGATGAGA
CAA.AAAAAAA
GAGCAITTTAG
GATAAGA-AAA
ATGGTAGCGA
TGGGTGAGCG
ACAGAAATCA
GATAGCGTTG
GATACGAAAT
CAGATCAATC
TACAAAGACT
AATAAAGTGG
TTTGA'DTTGT
ATCACTGATG
GACAGCGAAG
GCCAATATCC
GATAACAAGA
TATGGGGAT
AAAGGAGAAT
ATTTACTACC
TACGCTCA.AA
CCAGGCGTGA
AAAGAGCTTG
AAAGCGTTTG
ACTTCAGCGG
CAAATGGGGC
ATFF1'GCAAA
CTITATGATG
AGCTTTTGGA
TGATI'TCTAA
AATTAAAAGG
CCTTAACGAT
GCACGATCGC
AAGATAGCGC
GTAAGATIGT
ATGGTAAGGG
CCCTCTTFFI
TTAAAAAGTA
TTGAGGGCGA
AAGCGAGCGC
TACCAATC
AAGGCTCTT
TTAGGGTGGA
ATGACAAAGA
ATTrGCCCTT
GTTCGGCTTC
NFI'ACCATAA
TTGAAAACAA
GGATITCTIT
TTTTAGGCGA
AAGGCTATGA
ATGAATACGA
GFI'TGGCAGA
AAGAA.AATCT
TGGCTTTAAT
AAAGCGTGCC
AACTCTTAAA
GGCGAAGCTT
TTTGATGATC
CGCGAGCGAC
GCTGAATACC
TAAAGACAAT
TAAATCAGGC
CTTAATTGGC
CGTTCAAACC
CAAGTrGAA
AAA.AGAAGAA
TI'CTGAGCAT
AGGGGATAAT
TTTATGGAAA
GTF1'GCGCAT
AGAATACACG
TTATAAAAGC
ATTGTrGCCG
GAACGTGAGT
AGTGAAAAAG
ATTCTATGAG
AGAAAAACTT
AAAAGAATAC
AAATTI'AGAC
TGTTTTGTTA
TAAAACGCCC
AATCCATGAT
TAAAGATGAG
AGGCGATGAA
TGAAAGCAAG
ATGCGAAGAT
T
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1791 S S *5
*S
S S S S S. S S S INFORMATION FOR SEQ ID NO:351: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 468 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1.-..468 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:351 55 S S
S
GTGAA'PITAG
AAAAAGCATG
ITT1AAAGC
TIAATAATAA
CCTITAATCA
ATI'AAAAATA
ATAAG~rTT 'rTATCTTATC
GGGCTTACTA
TTGGTA'I'IGA
TCCACCACCC
ACGCTCTAGC
TCGTGGGCAA
AAGATI'TCAT
TAAAATCT1'
TCATCAAAGA
CACGCCCCCT
AAACTACACG
TAAAAAAATA
CAATCCTAAA
TCCCCCCTAT
TT1'TGAGATA TGCAArTTTA
AGCTAATTT
TATTrAGTGG
CITTTAGACA
GGAGCGGATA
AGAGAAAAT
AACGATAGAA
GACAACGATT
AAGCCGGCGT
AAGCAATTI'A
ATrCCCTTA
CCGCATGTGG
TTGACCCTAA
ATGGCATTAG
CTTCCI?1'AT
TGAAATCCCG
TTAITrGCGT
AAGCTATT
CAAGCTTITA
TAATAAAGAG
GTGTGATGCT
CCAAGATGAA
CAAACAAGAT
AGA'TI'AGGG
GCTACACCCT
120 180 240 300 360 420 468 INFORMATION FOR SEQ ID NO:352: SEQUENCE CHARACTERISTICS: LENGTH: 471 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAMTE/KEY: misc-feature LOCATION .471 (xi) SEQUENCE DESCRIPTION: SEQ, ID NO:352 0 0* *0 *0 *0 0 0 0* 0 0*0* 0* *0 0 00*0
ATGAAAAGCA
TCACAAGATA
ATTAAAACGC
GAACATTCTT
TATTTTTTGC
AACCCCTACY
CATATTCTTT
ATTATAATG
TT=TGCTCTT
ATTTTAAGGT
AAAACGAT
GGGTGGATT
CTTTTTATCA
AACGCAATGA
GGACTAAAGG
ACCCTCAATC
TATAATTITTT
GGATTATAAC
GTCCAATGCC
TGCTAAAAAA
TAG TTTCACC GTrTAAGTTC
CACGCTTTAT
CGCCCCCATG
GTAGTTTGTC
TACTATTTGC
TGGTATCTCC
TATTTAAACA
CCCATTTC
CAAATCAGTT
CTGGYTTATA
CGAATGATTA
AGTTAGAAGG
GCAAACAGGA
CTCCACAAAA
TGATGGATI'A
AATGGTACCA
TTAGAGTGCC
CCCAAACTAA
AATTTCATGC
CAAAAAATT
TFI'GCACATC
AGCCCCCAAA
TCTAGGCACT
CCCTAATATC
TGTATTTAGG
CTGGTTTCAA
C
120 180 240 300 360 420 471 INFORMATION FOR SEQ ID NO:3S3: SEQUENCE CHARACTERISTICS: LENGTH: 573 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: Thfisc-feature LOCATION .573 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:353 .0.
.00 0
ATGGGCTTGA
TTTGACTC'Fr
TATGTGGGGT
GGAGCGATAC
ATCGGTATCC
AAATACCATT
GGGGTGCTI'A
AAGCTTTTC.A
TGGGCGTGTC
TAGCTGATGT
ATAACT"I"GG
GATI'AGCGCG
CCATICCTGC
TCITAGAAGG
TGGTGAGCAA.
TCTTAGTGTr
GCAAGGCTI'A
GGTCGCTTTT
GCGTATAGGC
ATI'CAATATC
GGCGGCGGTA
CAATACCGAA
TATCCGCTAC
GATCITTTTA
CCAAACACCA
GGAGTCGCCC
ATGGCGGTGA
AGCACCAACA
TTGGTGGTGC
AAGTI'ATTTT
CCTAA'T1TTA
TCGTTAGTGT
CTAGCAAGTT
CAAGCCTTAT
GCGCGTTGTT
CAAGCGATCC
TTTGCGTGTT
TAGGCTTTAT
AAAAAGTCAA
TIGTGCGCCC_
TGGTATI'GAA
TAC'ITACTT
TGTGATT
CTATTCTI'TC
ATTAGATAAT
TGTCTrATTA
GTGGAATCTC
TFTAGAGGCT
120 180 240 300 360 420 480 TTGAGCGTGT TTATGGGGTT GTA TTT GATC TATGGCATCA TI'CGGTGGAT CTTTITAATG GTAAAAATTA CTTTTAATAA AAATAAAAGC GCA INFORMATION FOR SEQ ID NO:354: SEQUENCE CHARACTERISTICS: LENGTH: 270 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .270 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:354 'a.
a a.
0 W*09 ant.
at Ca C 0* .a 00 a a 4 0 .4 CO a at tt 9 t .t 4 at
ATGATAGGAG
GTAAGTAGGG
AATCTTTACA
CGGGTTAATT
GTATTATGTG
TTTACCCCAA
AGTTAGCGCT
TGA6ATGCTCG
TACATITCRT
ATGAAAAAGA
TTATTCCAAA AAGCAACTAA GGCTAATGGT ATTCTTACAG TATCGTTATG AARAATAATA TAGAAGTCTT GGTARCGTGT
TCTATTACGC
AACGCCCCTT
ACGCCTATGA
AAAGGAAACA
TTGATCACCG
AGTCATAITI'
CATTGAAGCA
TTATGAGCAG
CTCTAATCAT
INFORMATION FOR SEQ ID NO:355: SEQUENCE CHARACTERISTICS: LENGTH: 831 base pairs TYPE: nucleic acid STRANDE.DNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: iiisc-feature LOCATION .831 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:355
GTGAAAATAA
TI'GTAAAAA
T71"I7JGGCGG
CGTAAGATTG
TGCATAGAAG
CAA.TA'TrTGT
CCTTCTACGC
TACGGAAAAC
CCATAATGAT
TTCCCACCAA
CGATGGCTAT
TTTTI'GAGAA
TCAAACCCGA
TGATGCCAAC
CTAAC7T7I7I'
CCATTCCTGA
TAAAGATT
AAAACAAGGA
CAI'GTTGTG
ATGTTTGCCT
CGCCGGCTAT
GACTCACATT
TTACTTGTCA
TTATGCGATC
AACCACTATT
GCAAAAAAGA
AGTI'TAAACG
AATI'ATGAGA
GTGGTTTTAA
AGTGGCATTG
TGGCAAGCGC
TCTI'TGACGA
GTAGAAAAAT
TGAAAAAAGC
CCAAAGATCC
AAAATCAAAA
AAGATATTAA
AAAACCCTITT
GCGATTTTAT
TCAATTCTAA
AACGAGAGGG
GGGTITI' CT GAATGTGTTrG
TCCTTCACCA
CGGTCCGITG
GI'GCTTGAT
GAG'NAAAAA
AAAAGGGCGA
120 180 240 300 360 420 480
TCGCAAAACC
GATAATAATC
CATAAATATT
ATGCITGCTA
GTGCAACAGA
AATCGCGCTT
ATTTTCACAT
TAAAAALATAT
TGGCGCGTCG
AAGAAGTGCC
GCGATAACTC
CAGCCGAAGA
CCATA'FITCT
CAACAGCCGT
GGTAACAGAG
TAACGCGCAC
CTTTGTCTTG
GATTCAAGAT
TGCATTAGCC
TGGTCGCCAT
AGCGAATIAG
AAACGCATGG
TTAGCGACAC
CATGAATGCG
TTGATGTGCG
TATCAGGTGG
CGCAAAAAAG
GAGACTATGG
AATTTAACCC
CGATTTrGCG
CAAACAGCTG
CTTGAACCGGG
CCCGITTGTC
CTTGGCGGTG
ATTGACTIA
T
540 600 660 720 780 831 INFORMATION FOR SEQ ID NO:356: SEQUENCE CHARACTERISTICS: LENGTH: 174 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geriomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .174 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:356
C
C
GTGCTAACGA GTGGGGACAT GATCACTTGT CCGTATTGCG AGTACGCATG AAAGTAACGC TCAACCTCCA AAAGAAAGCC GAAAGCCAAG AAGAAAGCCA AGAAGAAAGC CA.AGAAGCCG GGCGTATTIT RTACGCTGAG AACCAAAAGA AAGCCAAGAA TCCGTI'TGAT TGTT 120 174 00 INFORMATION FOR SEQ ID NO:357: SEQUENCE CHARACTERISTICS: LENGTH: 837 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM:-Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .837 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:3S7
ATGAAATTGA
GGCT?1'AGGG.
GTFFITTrGC
GAATITGGTAG
TIATGGGC
ATTTTAGTCC
ATGACCCTI'
GGGGGTI'AGA
ACACGCATGA
GAAAGCGTTT
GCTCTTr AAAAAGdCCT
CACAAGCCCT
GTCTGAAATI
GCATTTGGAA
GAATGACTGC
CGTGAATGAG
TAATATI'ATI'
AATAAAGCCA
TTATTAGGCT
TIAAGCCACG
CCCATAGAGT
CATGTTTTAA
TCTCAATACC
AAAAAGAATT ATCGCCAAAA FTGTCTI'GCA AAAAGAAAGG AAGAAGAAAC ACGCTTFTT AITI'ATI'AGG AAGCTGTGAT TCCCACGGCC TGAAACCGAG AITI'AAAAGA AATAGGCGAA
ATCGGCATAG
ATTTATGCGA
TTTTGTCTAA
ATAGAA.ATGC
GTT-TCAAAG
GAAATCGTT
GACCAGTTAA
AAGGATTI'GA
GGAGCGGATG
GCGATATTTC
AAGAGCGTGT
TTGTCTCTAA
AACCGCACGA
TTFI'AGCCGC
AGAGCT1'GAA
GCGGCTTTGA
CGTGTCCGTG
ACCAAAAGCT
TTTTT.AAAA
CCCGCCCTAT
AGCCC111I'T
TAAATTAAAA
AGAATGCTTG
TAGAGGGTTT
AGTTI'GGCTT
TTAGAAGTGG
CAAACGCGCC
ATCGCTAGAA
GGGGGGGTTA
ATCCCTT
GAGTTIGCG
GTGGGCGTT
TAGAAAACCC
CGTTAAAAAA
,TTIGGGATCA
A'IATCCTTT
AAGGCGATGA
TGGTTTGTGA
GTTATGATGC
TAAAAAGTT1'
TAATCTCTCT
TATTGAACGC
TATGCCAACG
GGAAAAATCC
AATCTTAAAA
AATGGGGTAT
AGAGTTTTAC
TTTAAGA
p INFORMATION FOR SEQ ID NO:358: SEQUENCE CHARACTERISTICS: LENGTH: 108 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genornic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .108 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:358 ATGATTTCI7 TCATTGGGTT TGAATGCTCC GCATTAAAAG TITTAAC T ETTGGTI'AC ATAGTT'TA AAAGYTGGCA CTATAGCGCT ATAAGACTAA TTGTTATA INFORMATION FOR SEQ ID NO:359: SEQUENCE CHARACTERISTICS: LENGTH: 387 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE:- ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .387 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:359
GTGATCCAGT
AAGGGTCTrrr
ATGCCCATAG
~I CATrT
AAAATGAGT'
CTCACCCTAA
ATAAAACCAA
AAAAACGAGA
CTAGCATGCT
TAGAGAGCGC
ACAAACTCTA
CA.AAGAAGCC
AAGTI'TAAGC
TTGGGATC
GCACAAAAAC
ATITGAAGATG
TITTTAAGGG
AAGGTIT~CTA
TTGGCGTT
GAAT1'AGAAA
AAAAT'ATIT
TTTATAAAAT
AAATC7 1-17
TGCCCAAACG
ATGCATTCCA
TTATGCTAAC
CCCAGAGAGC
AGCGTTGCTr
AIGGACACT
ACGATACGAT
GCGCTAGGGG TGCGTTTTGA AGACATTGCA GGGGTGAATG AAGTCAAAGA AGAAITACTA GAAGTGATRG AITWTTTWAA AAAACCC INFORMATION FOR SEQ ID NO:360: SEQUENCE CHARACTERISTICS: LENGTH: 382. base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATUJRE: NAME/KEY: misc-feature LOCATION I. 381 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:360 360 387
ATGITI'GTAG,
GGATTGGATA
GGGATTTTGT
GAAATCTCCA
AAAAAACTCC
GCGAATAAAG
GGAAAATTTG
TTAAAATGGT GTTAGGG TTT TTT CACAAAC AGACATTATA GGTATTTTTT GGCTAAAAGA AACGCTTAGA AGAGATTCAA TTAAAGAA'IT AGAGCAAGCC AAGCCCTACA CGATCACGCA ATCAAAAATT C
TTGATCCTT
GAGCGTTCTT
TTGCGTTCAT
GCCCAACTTA
AAAGAAAAAG
AAAATACGAA
TAAGCCCTTT
TAAATTTCCT
TTTTGCA'rrC
AAGTGAGTAA
CTGAATTGAT
TTACAAACCA
GTGCGCTACT
CTTGTIGTG
CAAAAGCCTT
AGAACATAAG
TATTTCTGAT
AAATGGATGT
00. INFORMATION FOR SEQ ID NO:361: SEQUENCE CHARACTERISTICS: LENGTH: 885 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM:-Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .885 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:361
ATGAGGGTTT
AAACCGCCTC
TTCAATCATT
ATCGTATTT
CTCACGCGCG
ATTAACATTA
TAGAGTGGAA
AAACTI'TTAA
TAATCAAAGG
TCTCAAACGC
CTTTAAAAGC
GCTTTAATTC
ATAT'GGTI'A
AATACAAATT
GAGTI'CTATG
TCTAT1'AGCG
CCTTGTTAAA
TTCAGGCAAA
AATACTGATA AGTGGGATAC WTAAGATAC AAATAGGTAT AAAAACGCTr TCAAAGCGTT CAGGATTTAA AAATCGCTGC GAATTTCAAA AAGAACACCC CTCTACGCTC AAATCGCTCA
GCCCACCAAC
AATCAATAAC
TGCCTTGTTA
TGCTGCTAAT
AAAAGACGCT
AAACGCCCCT
TITGATTTAT
ACCCCTTTTA
AAAATGGATT
CCTAAACTAG
CCTAGTCTTA
GCCACCAAAA
AACCTCTCTT
ATCACTAAAA
CCTAAAGCTA
TCATFI'CAGC
AAGAAGAAGT
CTT1'AGAAAT
CCCCTTATGG
AATCTAAAAT
ACGCTCAAAT
ATI'TCATCAT
ATGGGGCTAA
GAGCTATCTT
GGATATTGCT
CTATGCTAAA
TCTTAAAGAC
AAAAGCCAGC
CAI'TTATGGC
AGGCTI'TGGA
TGATAAAACC
TAACCCTTTA
TAAAGAATAC
AGACCCAAAA
GGCGTGT'GG
CCTAAAATTA
ATGGAAGTCT
GC'FTCTATTT
GCGTTATCTT
CTITATAACC
GCCAAAGTTT
GGCTATATTG
AACTTTATGA
TT"rATGGAG
AACGTATCGC
TGGATCGTT
CTCAAGCCCA
TGATCGATAA
CTATIGAACA
TTAAAGATTT
TGGAT
TGAAAAAATA
TGAAAATCTA
TATGGCTAAT
AAAACTCACT
TCAATTCATC
AAA.AGACAAA
AGCCTTAATC
TrTATI'CAGC INFORMATION FOR SEQ ID NO:362: SEQUENCE CHARACTERISTICS: LENGTH: 378 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geriomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .378 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:362 a a a. a a a a
GTGGCTTTAT
AAGGTTACTT
CTCCATAAGG
GATITI'GCAT
GGCTGGGTT
TIGTTTGCAA
TGGTTGAGCA
TAGAGCCAAG
GGGGTCTTGT
ATTATAAAGA
CAAGCACCAT
TGAAAAAAGA
CTTGGTATT
AGATITAT
CGTGATGTAT
AGCGTI'AATC
CTATCTCACT
TATCATSCCT
AAAATTGCGT
CTTGCTTAAA
CTTACCGAAA
TI'GTGGTAG
TTCTTTGAAA
TTAGGCGGGA
CTI'TGAGCG
TACATCACCC
AGTATCAATA
GCGTGGTG'T
AAAGTCTT
TGRCAACCTI'
CGCACTF1'TT
CTTTAATTGT
CTCTCGTTIT
GATITTCTCG
TGATI'GGTrG
TATFI'TTATG
AGGCCCTAAA
GTTTTCCATT
INFORMATION FOR SEQ ID NO:363: SEQUENCE CHARACTERISTICS: LENGTH: 726 base pairs TYPE: nucleic acid STRA.NDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE:- NAME/KEY: misc_feature LOCATION .726 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:363
GTGGGGCTTA
ATTGAAGAAG
GAGCCTAGAA
CGCGTTCAAA
AA.AATTCAAA
TTGGGCGTGG
GCCCTACAAA
TTGAAGGAAT
GCTAAGAAAT
GGGCATGTCG
GCCAAGCGAT
GACAGYACTA
AAAGGA
TGAAAATAAG
TGGCTAGATT
GATTGGFI'
AGCATTTCAA
GCGTCGCCAC
TGGGAACGAT
GCGATGAGAT
TTTATCAAGC
TTTTTAACAG
TGGTGTGCAG
TGAAAAAGCT
TCCCTGTCGG
ATTTATGGGG
TGAAGAATTT
AGAAATCGCT
AGAAGACGAA
CAATTCCATA
TAGTITrGAA
CGCFTITAC
GTTTGAAAAG
CTTAGTAGAA
TGGGGGCGTG
TCAAAGGGAG
TCAAGCCT'A
CGGAGTGTTT
TGGCTITTAG
TTAAAACACC
TTAGGAATI'
GGGCGTI'TGT
GCCGAGAGCG
CCTTTTGAAA
GATTITGGGCG
ATCATI'ACCG
TTTTGCAACC
TATTITTTTCC
ATGGCGTATT
TTGTGGGGGA
GGGGGCAA3A AGCTCAAcAjA
TI'AAACAAAT
TTGATATAGT
GGCAGGTT
TCAAAAACAG
TTTTAGAAcc CTI'TGATTGc LATrGTrGTG
ACAAGCATT
TCAACCCTAC
TTGGAACGC
AGCGATCAAA
GCTTTTAAAA
GCATGACA-AA
GGCGTI'AGT
AGAAAATCTA
CGTGGTGCGT
CAAACGCATC
GCCTTITAAA
CGAACAAI1TA
CCCCCCTAAT
AATCATCAAA
120 180 240 300 360 420 480 540 600 660 720 726 INFORMATION FOR SEQ ID NO: 364: SEQUENCE CHARACTERISTICS: LENGTH: 453 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAMIE/KEY: misc-feature LOCATION .453 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:364
GTGAGCGATT
TGCGACGTT
ATTGAAGAGG
CTI'TGTTTGC
GCGGGGCGTG
GCTrATAGCG
GAGCCAGGCC
GATAGCGTTT
CTAACGCT1T
TGATCAATI'C
TI'AAAAAGCA
CCTTATTAAA
TGAGCATGCT
ATGCCTTGCG
CGGTGAAAAG
ATGCTFI'GGA
AAAGGAAGTG
CGCCGGTI'AT
ATTTAGCGTG
AAACAAGCCT
CTTIAGGC
ITI'AGAGCTT
CAA.TTGGGAA
AGTGAATGCG
TITITAAACA
GGGGTGTrI'G
AATITICG
TATTCTAAGA
CATI'ACAGCG
AAGCCCITTA
AAAACCGCTT
GCT
TCAGCGCTAA
GGAGCGTGGA
CCCTTTGTGA
TI'ITCAATCT
CGAGTAAGCA
ACGTTCAAGT
TTGAAAATGA
AGAAGATCAT
AGACACGCCC
AGTGGTGCAA
TTCTTCCATA
TGCCTTAGAG
GTGTTTGATI'
TGAGCGGAAA
C
INFORMATION FOR SEQ ID NO:365: WI SEQUENCE CHARACTERISTICS: LENGTH: 462 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .462 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:365
GTGATAGTGG
TTGGTTATTT1
TCTAGCTCTT
AGTGCGCGCA
CAAATCAGAG
CTCTCTAACA
GATTCTAATG
AAAAAACAAG
CGTGGCTTIT
TAGTOGATAT
TTATITGGCT
AATGCTACCA
AGAATTTAAA
TCGCTGAAGA
ATGAAAACCA
AGGAACTGAA
TAGGTAAA
TTGGGTGTAT
TTTAATCGCT
ATTCAGCCAA
AAACCGCTCC
AATCATFTCA
CAAAGACAAG
AGCTAGAAAG
AGCATTGCGT
AGCGATGTGC
TTACTAATCA
AAAATGTTTG
AATCGCAAAG
AAAAAACAAG
CTTTCTAACA
GATAAGGGGG
TTTCTATTTT
GCCAGTTTT
AGTGGGGCGT
CGTTAATCCA
ATGCTAAAAA
AAGAGTCCCA
TTACCGAAGA
AT
AATCACTCTG
ATTGGACACT
GATTGTTATA
AAGAAAAAGG
TTTTGAAAA
CCACAAAGAA
AATGATTCTC
9.
9 a 9 a a a. a a.
a INFORMATION FOR SEQ ID NO:366: SEQUENCE CHARACTERISTICS: LENGTH: 537 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geriomic) (iii) HYPOTHETICAL: NO (iv) ANI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .537 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:366
ATGAACTACC
GAAATCACTA
AGCGAGCAAG
TI'GGATTTT
CTGACTAACG
GAGTI'TAATA
GCCGAGAACA
AGACTITTTAA
ATCACAAAAA
CTAATCTACC
ACGAGCTITT
TGGAATTAAG
'FrAAGAATGC
CCGGCGAGAG
CGAGCATGCA
TTAAAAGCGR
CGAGCTATCA
ACAAAACCCR
TAACAGCGCT TTAGRGATAA AAAGCAATTA CAAAACGCTT CCTTAAATGC ATCGITAGGA GAATGAGA'rr GATAGCAGTI' CTTGAAATTA AAAATGAAAG TGCCAACGAG CAGGAAGTAA AA'ITAAAARG CTAGAAAATC
AATC
1 TTrA AACCAAGCCA AAGCCTTGAA GCGATTACAC GCGAACAGCC AGAAGTGAAA
TAAGGAGCAA
ITITAGAAGT
TAAGAAATTC
AATACGAGCG
CCAATACCTT
AATTGATAGA
GAGATAACGC
AAGCTAAA
CGCGCATTTT
GCTITTGAGT
CAFI'GAGTGG
CTrTTTTAGC
AAACGCTAAC
AACCACGACA
TAACAACCAA
CAACAGC
120 180 240 300 360 420 480 537 INFORMATION FOR SEQ ;D NO: 367: Wi SEQUENCE CHARACTERISTICS: LENGTH: 480 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genoraic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .480 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:367
GTGTTTGCCA
CCCATTTCAG
ATTTTATI'GG
GCCGTCCCTT
'TTTCACACT
TI'GAGCGATA
ATCGCGTTTC
ATCATGGGGC
CTGACAGCAG
GATCGCAAAA
ATTTATCGT
TAGGGCGATT
TGTFI'CTCAT
TTATFFI'TGG
CGGTTAAAAT
GTTTTAAAGA
TAGCTTTTCT
ACCCATTGTG
CCACCATCAA
TGTC1TTTGAG
AGGGTI'TTCT
CATGATCATG
TGCGATCGGG
AGAAATCAGC
ATGGGGCTTA
GGGCAAGCCC
ATCATTAT
CCAGAATTAG
ATGGCGTTCC
AAAACCCACC
TTTGTGGGCA
CTGGCC'TTA
CCATGGCGAG
TTTTATTGTT
TTGTGGATCA
CTAA)AACAT
CTATTTrATG
CTCAATTCAA
TTATTTAAT
GCGITATTRG
TGCTTATGAY
AGCGATTTTA
CAGCTTAAAA
TGTCAAAGCC
CTrGGTGTTA
CCTGCTCGCT
CGCTTCGGCT
TAAAATCTTT
too, .too 0.* INFORMATION FOR SEQ ID NO:368: SEQUENCE CHARACTERISTICS: LENGTH: 282 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .282 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:368
ATGTATGGCG
ITTGTTGAAG
CAGTTGCGTT
GGGCATACTI'
AAAAGCATGC
TGAAAGAGAT
CGCTTTITGG
TCCAAAAGCG
TATGCGTGGC
GGATCAATCA
TAAAGATAAA
GGAAAAAGAA
CTGGAGCCAA
GAITATGGGG
TlTTI'GGGC
A'ITGACAAGC
GATTTGAAAA
ACCCCAAGAG
TATTTATI'GA
GGGC771IT ~C
AACTCCACAA
AATTGGTGAG
TGCCACAAAC
GTTITGACTI'
CA
TAACGATCAT
CATGTTTGGG
CAGTGTTCTA
GAAAGCTTGT
INFORMATION FOR SEQ ID NO:369: Wi SEQUENCE CHARACTERISTICS: LENGTH: 438 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1. 438 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:369
ATGACTTTAG
ATCAAAACCA
ATCTCTTTTG
CCGGCGGGCA
CACAACGCTT
CTAGACAATTI
CACACGCTIT
ATGACTTAI'
AAAAAGACCA
GAWWGGACAG
TCTTTTCTGC
TAGAAAATTT
TACCCAGTAA
GCTTGAATGA
AGGGGGGAGT
AGAAAGGCTC
TGCCCCGCAT
CCCTATTTTG
GCAAGCCTT
AAAAGCGCAT
AAAAATCGCT
TTGGACCCGC
TTIATCCCTTG
TTCATTTCTA
TTGCCTGCGT
ATCAGTGATA
TGTCTAAAA
ATCTTAAGAG
ATTGTTTITG
C'FITAAAAGC
AAAAGCATAG
TGTGCGAACT
ACGCTAAAAA
AACCCTTTAT
GGGCCGAAAC
CAAACCCFI'A
CCACCCTAAA
CGCTAACATC
AATCTACGCG
AGTCCCTACG
GCTATCITGG
AACCTTCAAG AAATCGCC INFORMATION FOR SEQ ID NO:370: SEQUENCE CHARACTERISTICS: LENGTH: 519 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .519 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:370 p p p p p p. p p.
p PPP p
ATGGGCGTT
AGCCATAAAA
CTATCCCAAG
AACCTCTCTC
GGGTGCGAAA
GAGCCTAAAG
TTGAAGGCT
ATCCCTGG
GGITTTAAAG
TGGGCATGTT
TCCGCTTATA
ACACCCAAAA
AAATCrTAGC
AAGTGGATAA
ATCACGCTAA
TCATTCATAA
AATI'ACGCCG
GCTGTGAATG
CGCTrTTrI'
CCATGAAAAA
GACTTITTA
CCGCTATGAT
CCTITTTAAA
ACATTCCCTA
CGATITGAAA
CTACGCTTAT
CGATGCAAGA
TCATGGGTFI'
AAGGATTTG
AAAACAAAAT
TI'AAA6AGCTG CATrACCACA
GCTTATGAGC
AACGCCTTTG
AGAAATCGCC
GCATTTGA
TITTATTCAA
ACAAAMTGCT
TI'AAAAGCGA
ATTI'AAACAC
ATATAGAAAA
ATGCTTAF1'
AAGI'TTAAC
CAAAAAGGCA
GCACAATCTC
CAAACAAATC
TCTCGCTAAA
GCCAAATAGC
TAACACCC LT
TTCTAAACGC
AAACGCGCAA
GCAAAAAAGA
INFORMATION FOR SEQ ID NO:371: Wi SEQUENCE CHARACTERISTICS: LENGTH: 579 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE; ORGANISM: H-elicobaccer pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .579 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:371
GTGAGTGT'C
TTGAATTTAC
GGGGAGGGTG
GAGATTTTAA
CCTATTACAA
TTTGCGTI'
GAAAACCACC
GAAAAAAAGA,
GTGATCCCTA
GCGTGCAAGA
CTGCAACGAG
GCAATCGTTT
AAGGGATCCC
AAAAGCATGG
GGGGCATGGG
TAGGGTTTGC
CGGATAATAT
AAGTGATAAG
ATAGGGTCAT
AAGCGTGTTT
TGCGAATA
TTTTATTGAG
TAAATTIA
GAATGACGGC
GTCTAGCTCA
TTT1'GATAGA
CACCCCGGCG
TTTAAAAACC
TTCTACCAAG
AACCTTTCGC
GGCCCCGGTT
CCTAGTAATA
ACCAACAATA
TCGTTTAAAT
GCGATGATTG
GAAAACATTC
GTGTTTGGGG
AAAATCCCTT
CAATCGCGCC
ATGCGAGTT
TTGATIGCTT
TCCATGCGGT
TTTTCACCAA
TTITAGCA
TGGGGGCGGT
TCAATACTGC
GGTATAATGC
CTTTTTAAA
ATCTCTGCCC
GGGTTTGAGT
GAATGGTT
AGTGTI'TTAT
TAATAAAGTC
CGCTTCAGCG
TCTAATTIAT
AGCGTTTGTG
AGCGGTGATG
AAGCGTTACA
INFORMATION FOR SEQ ID NO:372: SEQUENCE CHARACTERISTICS: LENGTH: 312 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION .312 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:372 *.too too, to a.
GTGGCTAAAA
GCGATI'GGGG
TCAAGCGCGG
ATI'GAXAGCT
GGGCGCGAGT
TTCTTTAAGC
ATT'GGTAGC
TGATAGAGCC
AGTGGAAAA
TGGATTI'G'F
TAGAAGAATT
GT
GAGCGGGGTT
TGTGTCTATT
ATGCGTGAAA
AAGACCCAFI'
CACTTGGGAA
TGCGATAAAG
TATGTGAACA
TCGGTrCA
TATTCGCTCA
AAGACTAACA
CGACCGTGCA
CGCATAACAC
AACTCACGCC
CTTCAGCTTA
AGGTTGAAGA
GCTTGCTI'AT
GAGCAAGCAT
AAAAGGCATC
TGGGCATT
GATTAAAGCG
INFORMATION FOR SEQ ID NO:373: SEQUENCE CHARACTERISTICS: LENGTH: 1065 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1065 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:373
GTGCGTTTGT
GCTTTGGAAT
TCTGCGAACA
TTGCCCATT
CAATACACCG
TTGXITAGCC
ATGGAAGAAA
TTGTTAGTGA.
AAAGCCCAAA
GCTAAAGAAG
ATGCCCTTGA,
AAAACGCTCA
GTITCTATCA
AAAAAGTGC
AGCGTTTTAA
GGGCTAAAGT
TTCAGCATFI'
CTAGCTCTCA
ITAGATTTGT
TGTTTITGT
TGATCATTTT
CCTTGCTTT
CCCTGCTCTC
TGTI TIICAC
AAACGCAAAA
AATACAACGA
ATATCAAGGT
CTTC1IITTGA
GTTTTGAACT
AAAATTTCCG
CAGACGCTCT
GCTCG'1I1I17.
TCGCTTA'TrT
TI'ATCATTAT
CAGGGATACT
GTCTTTGGTA
GGGGTGGTAT
AGGCATTGAC
ATTTTTCACC
AGCGATGGTT
TA'ITGGATFI'
GGCTGTTI'AT
TTTAA'FITAT
TGATTACGTG
T'TICGCCTA
AGACAAATAT
GGGCGCGAAC
CCCTAAAGTT
TTTATCCTTG
GTATGTGTT
TTCGCCCAGT
CACGCTCGTT
CA 1TCCTGAA
TATTTCAAAT
AGCCTGAAAT
TATGATATTT
TTATI'TTATA
TCCAAATGCC
GTGGGGTTIGA
AAAGACAATT
TATTTTGATA
AAAGATAAAA
TGGATTTTAC
GCTITAAACA
TAGACACCA
CATGCTTIAG
GCGATrTTGC
CTCGCCCGCT
GTTTGGGGGC
ATAGGCGT'rC
ACTTTITAAT
ACGCCGATAA
TATTCGCTCT
TCACCTI'CAT
AGATTTTAAG
ACGCGACTCC
CTTTGAGCGT
AGATTAATCC
CTTTAGAATC
ATGACACTAC
CCACGCATTT
TTTATCAAAA
TGCGCCAAAA
CCTI'TIGT
ATGAAAACCT
TATTCTTTIGC
TATCGCCCT
GATI'G
CGTGCFFF1'A
AATGCCTGAT
CAATTACACC
TAAATCCAAC
CCCTATFI'TT
TTTTGTGTAT
TTCAGAGCAT
CTTATTGCAA
TTATGCTGAA
TATCTATGAG
AGAAACCTI'
CAAGCCTGCG
CGCGGACACC
GCCGTTTI'TA
GGCTCTTTI'A
T?1'AGGGAAG TTTCGTATrI' 120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1065 n.e
C
C.
C
C. C* C C
C
S a
C
CC..
C C C. C
C.
TTTTAAAAAA CTTAATAAGA INFORMATION FOR SEQ ID NO:374: SEQUENCE CHARACTERISTICS: LENGTH: 717 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KF.Y: misc..feature LOCATION I1.. .717 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:374
C.
C
C
ATGATATG
ITCCATI'CGC
GCGCGTTATG
CCTAATGAAT
GAAATCATGC
TACAAACAAG
ACGCITAAAA.
CCCATI'TGCG
AATGAAGAAA
GGCGI'AAAG
GAAAGAGCCC
TTTGATTTAG
GCGTITTAGA
TTAT1'GT'
AAGAITTTGAT
TGAAAATGGA
CCTATAAAAG
CC71AAGGGG
ACITACCCCT
TGGTGGGTAA
AATTCATCAT
TGGATFFI'CA
CCCTAGAAGA
CCAAAGAAC
CGGCTTGTT
TGAAGAAAAT
TAAAAAAGGG
~TrITTGAAA
CGCTTTTAAT
TTGGGGGAGT
ATACCAAACC
TGGGCCAAGC
7"1711"rCATGC
AATAGAAGTG
CACCCCCTTA
GT1'GATGTTr
TTGGCTATFI'
TTAGACITGT
GCTAAACTT
CGCCCTATCA
?I'GCGCATGC
'TTGAAGACG
CTAAAAACCA
CTGGATTTAT
GGAACCGCTT
GAGCGCATAG
ATGGGCGCTA
ATGCGTGGGG
TACAGGCTCA
F1AAAATCAG
TTAITCAAGG
CGCATTCTT
GAGAAAACAT
AATGCTAGG
AACCCAAAAA
TGTTAGATFI'
TAAAGCCTIT
ACTATCTTAA
ACATGCTCAA
GGAGCGCTTG
AAATTACCGC
TTGCTATTT
GTTITTTAAC
TITAAAGCTA
TCAAAGCTAT
G LTAAAGAAC
AATTAACGCC
TI'TAAAAGAA
AAAAGCGCAT
GGAGGTTTTTA
TCCTAACGCT
CGCAGTA
120 180 240 300 360 420 480 540 600 660 717 316 INFORMATION FOR SEQ ID NO:375: SEQUENCE CHARACTERISTICS: LENGTH: 867 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KE:Y: misc-feature LOCATION 1 .867 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:375
S
S. S S S *5 4
ATGCTGGCGT
GCGTTATTGT
CCCTI'AATCA
TTI'GAAAACC
GGAF1'TGATT
TTATCTTTAG
TACAGAATGA
AGCGATITAA
AAATTTGACT
GCTCAAAGCA
GAAAACTCCC
GGGACATTGC
AGCGTI'CAAA
GAGTI'TCTTC
TTTTAAAAAC
TTI'ACTGGTG
TTGTTTTAGT
CCTACTI'CAG
GGTTAGTCCC
GGCTTATT
TAGGGGTI
5
IT
AAGAGGTI'GG
CAAATTACCT
AGCAAAAAAC
CTTI'TAAAAC
GCGCTCARGG
TCGCTGATAA
AAAAACCCCT
CCCTAGAAAC
CGCTTTAAGG
AGCGTTAGTT
GCTTTTGAGT
GGATAGCII
TTAGCTI'GC
ATI'GCTGCTI'
AAATATI'GAA
TAATAATATI'
CTTGATI'GTT
CCAACTAGAA
CTATAGCCT'
AGTGATCTI'A
TGAAAAGCTC
AGCGCTTTG
CTITCGCATT
TATGGGGTTT
TTITTAGGCT
T?1'TCTTATA
ATTITTTTTGA
GGCGCGTTGG
TTAGTCTCTA
GAAAACAACA,
'FITCCAGAGA
GA
1
FITAAGCG
TATAACAGCT
GCCCCCTTTG
TTT~rI'CA CTTTG GGTYT
CGGATTTCAC
TATITTATTT
CTAGTITTTAT
GCGTGTTTAG
GCGCTCAAAA
ATTTTCATIT
CAAGAACGCC
TI'CTTAAAGA
CCGCTTACCC
ACAAGATCGC
CGTTTATT
GCGAGATAAT
GAGCGCTTAT
TTTCGTGGGG
YTATTTATTG
GFI'GCTCTAT
CCACCCTTTT
GGTGGATAAA
TCTTAAAAAA
TTTTAAAATA
CCAAGATI'G
AATCAAACTC
TATCGCTTTA
CATTI'AATA
TTCTAAAAAA
GCCTTTACCG
TTATACCGCA
120 180 240 300 360 420 480 540 600 660 720 780 840 867 ACGCTCCCCA TITCAGCGAT TITACAT 5.
S S INFORMATION FOR SEQ ID NO:376: SEQUENCE CHARACTERISTICS: LENGTH: 1308 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE:.
NAME/KEY: misc_feature LOCATION 1308 (xi) SEQUENCE.DESCRIPTION: SEQ ID NO:376
AT.GAACGATC
GCGTTAGGGT
ATTGTGGGTA
TTGAATTTGC
AAAATGAGTA
ATTGAAGAAT
TCTAAAAAAG
TTGAATCGTT
ATCACTGCGT
TCTTTTGTGC
TTTTTGAATA.
GAAAAATTAG
CTCTATGCGT
ACGCCCAATA
GACACCGAGC
ATTGAAAAGA
GAAJ.AGCCC
ATTAAAGTGG
TTAAAAGTGG
TATGAGCCTG
AAGCTTATGG
GCTTTAATCA
CTAAGCATGT
ATTTGAACGG
AGGATATTT
CCTTATTCAA
AGAGCTTGGG
TACGCTXITI'
CrGTTAGTAGA
TGCTAGGCAT
ATTATCCTAA
CTAAAATGCA
AACTCATCGC
AAGCCTTATTI
TCATGCCAAA
ATTACGAACG
CTTATITTTC
TTGAAAAAGG
CACCAACACA
GGCTTATCAA
ATTTAGGCGA
AAAGCTTGGT
GTGAAATGAG
GCCCTACCAG
GGTGTATGTT
TTAGACAAT
ACGCTTCCAT
ACAGCTCTGT
TAATGTTTTA
TTI'ATTGCGT
ACGGATTAAT
GGCTAAAAAG
AGAGCTAGAA
ATTGCATAAG
TAAAGAAGAG
GAGTTTGATC
GAGCGCTATG
CTTITTAAG
CAA.AATTGAG
GGAGGAAGCC
AGAAAATTAT
AGAAGCTCAA
AAATCGTITG
GGGTCAAATG
TGAGGGCATG
AGAAAAAATT
TGGCTGGACG
AAAATGGCGC
GCCATTTATT
GTGCATGGGT
GACGCTCAAA
GAGGTGCCTT
GCGAA'TrGA
TATTI'CAATT
AAAGCACATC
GCTTTAGAGG
CCGTGGGTCT
GCAAACACGC
AAATTAGCGA
GCTAAAAAAT
AAAATTGAAA
CTAGCAGAAA
ATTAGTATTG
AGGATTGAAA
AGGCAGATCA
GTGTGCGTGG
ATTITAGCGG
GCAGGAAGTT
CTTTATTGAA
ATTTTGAACG
GGCCAGCCTT
GGTGGACGAT
AGCTCGCCAT
TTGGGCAAGA
ATAACGATTT
ATTCTCTAAA
AAATTTTAGA
AATTGTTTA.A
TGCACAAAAA
TACTACAATC
GCGCTTTTCG
TACAAGATAT
AGATTGAA.A
AAGCAGAAAA
AGGATTTCAA
AATCCAATAA
TCTCAGGGAT
TGGCTAATTT
TGCGAGATAA
TGATCAGC
TTATGCGAGC
CGCTAGGCAT
TTTGATGAGT
AGAGGGCGTG
GGAGTATGGG
TGGGGATTFT
GGGGAATTTG
AAGCACCAAA
TAACGCTAAT
TATTrATGAT
CAACGAATCA
A6AGCTTCTTG
TGTAGAAATC
GGT?1'TACAA GATrGAAAAG
AAAAGAAAAA
GAAAGTAGAG
ATTACTGCGC
CGCTITGGAT
AAAACCCGCA
TGATAATCTG
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1308 q S. S *0 9055 .4 S S
S
INFORMATION FOR SEQ ID NO:377: SEQUENCE CHARACTERISTICS: LENGTH: 342 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL.: No (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .342 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:377
S.
*flS
I.
:ATGAAACGAC
AAACATFI'AG
GGTITITI'AA
TTCTI'GTTTG
CTCGTTICTC
AAGCTAATCA
CGATCAGCAA
ATAAGTACAG
TAGCGCTT
CTCITATAAT
TCAGCATAAT
TGCTTATGAC
ATI'GAAACAA
CC'TrATTAT
TTCTTATGGG
AAAACCTAGC
AALGCAAATAC
TCAATGGCAA
AACTI'TTTAC
AGGCTG'ITCA
GCAGGGGTGA
TTTTTTTAT'
TATCTCCTAA
AATTGGITCT
AATTCAAACA
ATATCAGCTC
ITTTAGTTTA
ACACTACTTA
GCCACGCAAA
TA
TTCTITCAAC
TATCGI'TATA
TCCAATATTA
TCITI'TGCTA
TTTCACAATG
120 180 240 300 342 INFORMATION FOR SEQ ID NO:378: SEQUENCE CHARACTERISTICS: LENGTH: 5 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION (xi) SEQUENCE DESCRIPTION: SEQ ID NO:378
ATGGG
INFORMATION FOR SEQ ID NO:379: SEQUENCE CHARACTERISTICS: LENGTH: 381 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .381 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:379 V.
V
V.
V
GTGTTCACT
ATCACTTATG
GTTTTATCAG
GAATATGGGG
TITGGCCAAA
ITTTGCTGGC
AAAGTATCAA
ATTCC'ITGGG
CTGCCGI'AC
GRATTTTAAT
CTAATGTCTC
TGGGAGCGAT
ATCACTTCTA
TACTCTCGTI'
GCAGGTTTC
GGATAAAACG
TTCTCTI'GTG
ACAAGGCACA
AGGCGTrCCT
CGGTGGCTTT
T'
TTI'TCTCTAA
CAGAA'TrTGC
RCAGGGCTTA
GGGTI'AATCT
TG2TTCAAT'
ATI'AGAGCCA
GTATCGGTTT
F1'AAAAGCAC
TGAVITTTCAC
TCACTTCTTI'
CTITrCTTGC
AGCGTGATGT
AGGGATCAAT
GATITGGGTG
TTTGTGTTT
ACCGGTGGTr
TCGCGCTCGC
ATCI'ACCGA
INFORMATION FOR SEQ ID NO:380: SEQUENCE CHARACTERISTICS: LENGTH: 517 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc_feature LOCATION .537 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:380
ATGAAACCAT
ATTAAAAACC
TTTCTATGGC
AGCGTTTTAG
AAAGAAACCA
GAAAAGATCT
CCCTCCCAAA
CTTTTTTTCA
ATTTCTA.AAG
TGCATITrTC
TTATTTTTTT
CTAGCATGCT
AATACGCGCA
GCGAATCTTT
TAAAAAAATG
AAACCCAATT
CCTTAATCAA
ATAGCGACGG
ACACCTGGAC
AGGGGTITTI'
GGAATI'AAAA
AAGGCATTT
GTTAAAGATT
TTTTGACGCC
TTTrATCATG
CAAGTATTTA
GTTGITGGTG
AGAGAGCAAT
TCCTTATTGG
AAAATCCTTT
GAAACAGCCC
TTTAATGATG
TATAAAATCA
GCTAGAGCGA
CCGAGCGCTC
CAATFI'GGCG
CAGGCGATGT
GTGGTTGAA
TAGAAGAAAA
TAGCAAACTA
AAGAGTCCAG
AACCCTTGCT
GCGAATTGGA
AAAGCCAAI'
TGAGTATTGA
GGGTTTTATC
TACCGAGTAT
TCGTAAAAAA
CCGCAATCAA
GCGGATTTIA
CTCTCAAAAC
AAAAACTTAT
GCCCTTAAAG
TCTCCAA
120 180 240 300 360 420 480 537 a. a a a a INFORMATION FOR SEQ ID NO:381: SEQUENCE CHARACTERISTICS: LENGTH: 627 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .627 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:381
ATGAATGCAT
ASCCCARYGA
AAAAACCGGA
GTAGCGTATG
ATCATGTGGC
GTGATTGGGG
CCCATIGTGG
AAAGGCGAAA
TI'ATTAGATG
AATAAAGCGC
TCAAGCGCGC
TGA.AGCGTGC GTGTITAAGA GCGACGCTTT CACACGGAGC T1'GAAAATTA CGAACAACC TGGGCGATGT GGTIGGCACA AT TTT GGTAA GGACATI'CCT GGGTGATCGC TCCGATI'TTC CTGATGTTAA GGATTTGAAA TCACGCTGAA CGATAAGGTG AAGTCAGGGC ?I'CTGGGCGT GTAAAITI'T GGGCCGGCGA TAAGGCTACA CTITGCC
TTGATGGGCG
GATATI'CCTT
AI'GAAGCCA
GGAAGCTCTA
TTTGTGCCTA
?I'TGCGACTT
GAGGGCGATA
GI TAGCACCT ATCCCCT1'AA
ATCGGAAGCG
AAACCAATAC
TACACGCCAA
ITAAAACTAA
GAAAAAGCGC
ATAAAAGGAG
GTGAAGATAG
TCATTAAAAT
TI'AAGCTAGA
TCAT1'GGTAG
TTCAAAAAAC
CGATGATI'A
AGCCATGCTA
AGGCGTCCT
GACTAACTCT
TGGAGGCATT
CGGGGCGTI'A
CTACCCTTAT
GCCTGAAACT
GGGTTTGACC
CTTCCGCCCC
INFORMATION FOR SEQ ID, NO:382: SEQUENCE CHARACTERISTICS: LENGTH: 702 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO 320 (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .702 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:382
ATGCTI'TCAG
GAGCATAACG
CAAGGTTATG
SCCGTAGGGT
A'ITGTGCCAG
CCAAGCGGGC
TTTGCAATGG
GATGTGGGCA
ATGGGGTTGC
TTAGTAGAAG
ATTGATGAkAA
AACCACACT
CCCACCAACC
CCTATGCGAG
AGGGAATGGA
TAAGCCATAA
GCTTGCTCAT
CTATGGTGAG
GAAAGATCAA
CF1'GCACTTT
ATGTGGCCAA
AGAGCGCTAA
AAAGCATI'CT
TGCATTTGAT
TTTAAAA.AT
CGTCGCTAGT
ATI'GAGCTrG
TGTITTTGAC
AGGAGCGT'A
CGGGATAGAA
CAGAGAAGAG
TTATGGCACG
TTCTAGCTTT
AAGATTAGCG
TAACGCTCTT
CGCTATCGCA
TACCCTGATC
GGGGTGCCAG
TTTAGTAGAG
GGGGCGTTTT
AGCTTTGGGA
AATATAAAA
CTTTI'AAAAG
GCTAATTCTA
ATCAACCCTA
AGCGGGAAAG
ATAGGCTI'AA
GATCTTGTGG
TGATTAAAAA
CGATGTGTGA
ATGTGATCGC
T'FFIGGGCGT
ATT"TAGCGAG
AAGCCAAAGC
TGGAAATGCA
ATCAAATGAT
ACAACCCCTT
TCCTGCCTTT
TGGCAACAGG
GG
AGAGTTGCAA
TGGTATCACG
A ITAAGCACC
GTGCGATAAA
CGTG ITTGTG
GCGCCAAGAT
AAGCTATCAT
GATGGAGT
ACGAAAGGTT
AGCCAAACTC
GGGTTCTACT
INFORMATION FOR SEQ ID NO:383: SEQUENCE CHARACTERISTICS:, LENGTH: 795 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1. 795 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:383 000 0
ATGAAATT
CTI'CTTTGCA
GGCTTT'rrAG
AAAAAACGCT
GTGGCAGAAA
ACGCTTTTAG
TI'GCTITACT
AGAGCGCTI'G
AGCGTTCGTA
TCTCT'C'T
GCCATAAAAT
ACGGGCGATA
AACTCTATGG
GAGAGAGAGA,
TAAAATTC'Fr
ACGCTCT'TC
GCGCTTTTTT
TGAAATAT'C
TITTACGCT
CCACAAACAG
ACGCTTTGAT
TGCCTGGTGT
ACATITAAACA
TAGCTAGGGG
TTTATAGCT
'TTCAAATGT
CTATAGCGTT
GAGAG
TGCCAGTAGC
TAACGCTTAC
AA.TCGGGTr
ATTAGAATGG
GTTrATGTTT
CTCTGAAACG
'FI'IGATCGCT
GATAGCGAGC
CC'ITACAAAG
GTITTTATTCC
TTTAAATAAT
CGTCTI'AGTC
CCTAATAATC
GTAACTCTAG
AAAAATAGCG
GTGGTGTATT
CTGTTTATAG
AAAATGCC1'
ATGGCGTI'TA
TTGTI'GATCG
GTTTAGGGC
AACGATGCGA
GCTTATF1'GA
CTTTATTTAC
ATCGCGAAAG
CCTTATSCGA
ATGAAAAAT
ATTTGTTTTC
ATGGTI'GCGC
GAAGCGGTAT
TITCCAAAGG
TAAAAAGCTA
CCATI'AAAAT
TI'TCTATCCT
TTIAAAAAG
GTI'TGTTTGA
CAAGCGAT'A
CGCGAGCAGA
GCGAACTCGC
TTI'AATGTTC
TTTCTCTAAA
GCTAATCCCT
TAITTI'TAGC
CTTGATTGAC
TAAAAAITAT
CATrCGCTrr
TACAATAGGG
ATCACTCTT'
TCGCCAACAA
TCITI'CTAGC
AATTI'CATGC
CAACGAGAGA
120 180 240 300 360 420 480 540 600 660 720 780 795 INFORMATION FOR SEQ ID NO:384: SEQUENCE CHARACTERISTICS: LENGTH: 509 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...509 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:384 Met Cys Ser Gin Glu Ile Leu Ser Ser Leu Gln Thr Ile Ile Ala Glu 1 5 10 Gin Phe Ser Ile Asn Ile Ile Thr Gin Leu Ala Asn Lys Leu Thr Gin 25 Val Lys Asn Leu Asn Phe Phe Glu Asn Lys Asp His Thr Ile Lys Leu 40 SAsn Thr Ile His Asn Gly Leu His Ile Arg Pro Leu Asn Tyr Val Ser 55 Asn Leu Phe Phe Asn Leu Gin Arg Ile Ile Gly Leu Ile Ser Leu Phe 70 75 Gly Ile Leu Phe Ser Ile Ser Ile Tyr Leu Pro Phe Ile Met Ile Phe 90 Ala Thr Val Pro Cys Ile Leu Ile Ser Asn His Ile Ala Lys Lys His 100 105 110 Ser Ala Ser Ile Asp Lys Leu Gin Asp Gin Lys Glu Ser Met Gin Asn 115 120 125 Tyr Leu Tyr Ser Gly Leu Asp Asn Gin Lys Asn Lys Asp Asn Leu Leu 130 135 140 Phe Asn Phe Met Leu Asn Phe His His Lys Phe Ile Glu Thr Lys Glu 145 150 155 160 Leu Tyr Leu Asn Asn Phe Val Lys Val Ala Gin Lys Asn Leu Ile Phe 165 170 175 Thr Ile Tyr Ala Asp Val Leu Ile Thr Thr Leu Ser Ile Ala Leu Phe 180 185 190 Phe Leu Met Val Phe Ile Ile Leu Ser Lys Leu Ile Gly Val Gly Ala 195 200 205 Ile Ala Gly Tyr Ile Gin Ala Phe Ser Ser Thr Gin Gin Gin Leu Gin 210 215 220 Asp Leu Ser Phe Tyr Gly Lys Trp Phe Phe Ala Ile Asn Lys Tyr Phe 225 230 235 240 Glu Asn Tyr Phe Cys Ile Leu Asp Tyr Lys Ile Pro Lys Pro Glu Thr 245 250 255 Gin Ile Lys Leu Glu Glu Lys Ile His Ser Ile Thr Phe Glu Asn Ile 260 265 270 Ser Phe Ser Tyr Pro Asn Ser Lys Leu Ile Phe Glu Asn Phe Asn Leu 275 280 285 Ser Leu His Ser Asn Lys Ile Tyr Ala Leu Val Gly Lys Asn Ala Sen 290 295 300 Gly Lys Ser Thr Leu Ile Asn Leu Leu Leu Gly Phe Tyr Thr Pro Asn 305 310 315 320 Ser Gly Gin Ile Ile Ile Asn Asn Lys Tyr Pro Leu Gin Asp Leu Glu 325 330 335 Leu Asn Ser Tyr His Gin Gin Met Ser Ala Ile Phe Gin Asp Phe Ser 340 345 350 Leu Tyr Ala Gly Tyr Ser Ile Asp Asp Asn Leu Phe Met Gin Asn Asn 355 360 365 322 Ile Thr Lys Glu Gin Leu Lys Gin Lys Arg Glu Ile Leu Lys Ser Phe 370 375 380 Asp Glu Asn Phe Gin Asn Cys Leu Asn Asp Cys Asn Asn Thr Leu Phe 385 390 395 400 Gly Ala Gin Tyr Asn Gly Val Asp Phe Ser Leu Gly Gin Lys Gin Arg 405 410 415 Ile Ala Thr Met Arg Ala Phe Leu Lys Pro Ser Asn Cys Ile Val Leu 420 425 430 Asp Glu Pro Ser Ser Ala Ile Asp Pro Ile Met Glu Lys Glu Phe Leu 435 440 445 Asp Phe Ile Phe Lys Lys Ser Gin Ser Lys Met Ala Leu Ile Ile Thr 450 455 460 His Arg Met Asn Ser Val Lys Gin Ala Asn Glu Ile Ile Val Leu Asp 465 470 475 480 Gin Gly Lys Leu Ile Glu Gin Gly Asn Phe Glu Thr Leu Met Lys Lys 485 490 495 Gin Gly Leu Phe Cys Glu Leu Phe Leu Lys Gin Gin Tyr 500 505 INFORMATION FOR SEQ ID NO:385: SEQUENCE CHARACTERISTICS: LENGTH: 172 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...172 o e (xi) SEQUENCE DESCRIPTION: SEQ ID NO:385 Met Lys Gly Pro Ile Leu Trp Pro Ala Phe Ser Gin Phe Ser Asp Gin S1 5 10 Asp Leu Ser Asp Ile Val Ala Tyr Leu Thr Ser Ile Leu Pro Lys Asn 25 Leu Ser Asp Lys Glu Val Phe Ala Gin Ser Cys Gin Arg Cys His Ser 35 40 S* Leu Asp Tyr Ala Lys Asp Lys Ala Phe Ser Asp Pro Lys Asp Leu Ala 55 Asn Tyr Leu Gly Ser His Ala Pro Asp Leu Ser Met Met Ile Arg Ala 70 75 Lys Gly Glu His Gly Leu Asn Val Phe Ile Asn Asp Pro Gin Lys Leu 90 Leu Pro Gly Thr Ala Met Pro Arg Val Gly Leu Asn Glu Lys Ala Gin 100 105 110 Lys Gin Val Ile Ser Tyr Leu Glu Lys Ala Gly Asp Arg Lys Lys His 115 120 125 Glu Arg Asn Thr Leu Gly Ile Lys Ile Met Ile Phe Phe Ala Val Leu 130 135 140 Ser Phe Leu Ala Tyr Ala Gly Lys Glu Lys Phe Gly Ala Lys Cys Ile 145 150 155 160 Lys Phe Lys Lys Gly Gly Thr Trp Phe Tyr Asp Phe 165 170 INFORMATION FOR SEQ ID NO:385: SEQUENCE CHARACTERISTICS: LENGTH: 172 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...172 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:385 Met Lys Gly Pro Ile Leu Trp Pro Ala Phe Ser Gin Phe Ser Asp Gin 1 5 10 Asp Leu Ser Asp Ile Val Ala Tyr Leu Thr Ser Ile Leu Pro Lys Asn 25 Leu Ser Asp Lys Glu Val Phe Ala Gin Ser Cys Gin Arg Cys His Ser 40 S Leu Asp Tyr Ala Lys Asp Lys Ala Phe Ser Asp Pro Lys Asp Leu Ala 50 55 Asn Tyr Leu Gly Ser His Ala Pro Asp Leu Ser Met Met Ile Arg Ala 70 75 Lys Gly Glu His Gly Leu Asn Val Phe Ile Asn Asp Pro Gin Lys Leu 85 90 Leu Pro Gly Thr Ala Met Pro Arg Val Gly Leu Asn Glu Lys Ala Gin 100 105 110 Lys Gin Val Ile Ser Tyr Leu Glu Lys Ala Gly Asp Arg Lys Lys His 115 120 125 Glu Arg Asn Thr Leu Gly Ile Lys Ile Met Ile Phe Phe Ala Val Leu 130 135 140 Ser Phe Leu Ala Tyr Ala Gly Lys Glu Lys Phe Gly Ala Lys Cys Ile 145 150 155 160 Lys Phe Lys Lys Gly Gly Thr Trp Phe Tyr Asp Phe 165 170 INFORMATION FOR SEQ ID NO:386: SEQUENCE CHARACTERISTICS: S* LENGTH: 133 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_fea'ture LOCATION 1...133 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:386 Met Glu Arg Lys Thr Leu Gin Ser Ile Leu Cys Leu Ile Lys Lys Glu 1 5 10 324 Met Met Arg Pro Lys Gly Ile Leu Met Asn Cys Cys Arg Thr Trp Lys 25 His Gin Val Leu Lys Gin Ser Thr Thr Gly Leu Val Val Leu Ser Ile 40 Ile Ser Ser Thr Ala Pro Phe Ile Gly Leu Phe Gly Thr Val Val Glu 55 Ile Leu Glu Ala Phe Asn Asn Leu Gly Ala Leu Gly Gin Ala Ser Phe 70 75 Gly Val Ile Ala Pro Ile Ile Ser Lys Ala Leu Ile Ala Thr Ala Ala 90 Gly Ile Leu Ala Ala Ile Pro Ala Tyr Ser Phe Tyr Leu Ile Leu Lys 100 105 110 Arg Lys Val Tyr Asp Leu Ser Val Tyr Val Gin Met Gin Val Asp Ile 115 120 125 Leu Ser Ser Lys Lys 130 INFORMATION FOR SEQ ID NO:387: SEQUENCE CHARACTERISTICS: LENGTH: 158 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...158 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:387 Met His Glu Arg Ile Glu Arg Gly Ile Unk Asn Asn Glu Cys Lys Glu 1 5 10 Ile Phe Gly Asn Glu Leu Lys Gin Arg Lys Thr Lys Leu Ile Glu Asp A 20 25 Ile Glu Arg Arg Phe Lys Glu Cys Glu Glu Gin Phe Arg Gly Ser Val 40 Gly Lys Asn Ile Glu Gin Leu Glu Glu Arg Val Lys Asp Ser Leu Ala 50 55 Ile Ile Lys Arg Ile Asn Asn Leu Gly Leu Asn Pro Asn Ser Asn Phe 70 75 Asn Met Asp Ser Gly Ile Asp Thr Ile Gly Leu Phe Ser Ser Ile Gly 90 Gly Leu Val Leu Leu Leu Leu Thr Pro Val Val Gly Glu Phe Ala Leu 100 105 110 Ile Ala Gly Val Gly Leu Ala Leu Val Gly Val Gly Lys Ser Ile Trp 115 120 125 Ser Phe Phe Asp Ser Asp Tyr Lys Lys Ser Gin Gin Arg Lys Glu Val 130 135 140 Asp Lys Asn Leu His Gin Ile Cys Glu Lys Leu Cys Arg Met 145 150 155 INFORMATION FOR SEQ ID NO:388: SEQUENCE CHARACTERISTICS: LENGTH: 112 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...112 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:388 Met Pro Gly Val Tyr Gin Met Ser Ile Glu Pro Leu Leu Lys Glu Cys 1 5 10 Glu Glu Leu Val Gly Leu Gly Ile Lys Ala Val Leu Leu Phe Gly Ile 25 Pro Lys His Lys Asp Ala Thr Gly Ser His Ala Leu Asn Lys Asp His 40 Ile Val Ala Lys Ala Thr Arg Glu Ile Lys Lys Arg Phe Lys Asp Leu 55 Ile Val Ile Ala Asp Leu Cys Phe Cys Glu Tyr Thr Asp His Gly His 70 75 Cys Gly Ile Leu Glu Asn Ala Ser Val Ser Asn Asp Lys Thr Leu Lys 85 90 Ile Leu Asn Leu Gin Gly Leu Ile Leu Leu Lys Ala Val Trp Ile Phe 100 105 110 INFORMATION FOR SEQ ID NO:389: S SEQUENCE CHARACTERISTICS: LENGTH: 65 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...65 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:389 Val Glu Asn Asn Lys Ser Leu Lys His Ala Asn Glu Leu Arg Asp Lys 1 5 10 Arg Asp Glu Leu Glu Phe His Leu Arg Glu Leu Phe Gly Gly Asn Val 25 Phe Lys Ser Ser Ile Lys Thr His Ser Leu Thr Asp Lys Asp Ser Ala 40 Asp Phe Asp Glu Ser Tyr Asn Leu Asn Ile Gly His Gly Unk Asn Unk 55 Ile INFORMATION FOR SEQ ID NO:390: SEQUENCE CHARACTERISTICS: LENGTH: 61 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...61 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:390 Met Gln Glu Phe Ser Leu Trp Cys Asp Phe Ile Glu Arg Asp Phe Leu 1 5 10 Glu Asn Asp Phe Leu Lys Leu Ile Asn Lys Gly Ala Ile Cys Gly Unk 25 Thr Ser Asn Pro Ser Leu Phe Cys Glu Ala Ile Thr Lys Ser Ala Phe 40 Tyr Gin Asp Glu Ile Ala Lys Unk Gin Arg Gin Lys Ser 50 55 INFORMATION FOR SEQ ID NO:390: SEQUENCE CHARACTERISTICS: LENGTH: 61 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...61 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:390 Met Gln Glu Phe Ser Leu Trp Cys Asp Phe Ile Glu Arg Asp Phe Leu 1 5 10 Glu Asn Asp Phe Leu Lys Leu Ile Asn Lys Gly Ala Ile Cys Gly Unk 25 Thr Ser Asn Pro Ser Leu Phe Cys Glu Ala Ile Thr Lys Ser Ala Phe 40 Tyr Gin Asp Glu Ile Ala Lys Unk Gin Arg Gin Lys Ser 55 INFORMATION FOR SEQ ID NO:391: SEQUENCE CHARACTERISTICS: LENGTH: 619 amino acids TYPE: amino acid TOPOLOGY: linear
I
(ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...619 (xi) SEQUENCE DESCRIPTION:.SEQ ID NO:391 Val Phe Val Ala Ser Lys Gin Ala Asp Glu Gin Lys Lys Leu Val Ile a a a.
a a a 1 Glu Ala Gly Ile Ala Leu Met Phe Ile 145 Ser Leu Asp Ile Phe 225 Tyr Gin Gin Phe Leu 305 Lys Tyr Ala His Leu 385 Glu Gin Asp Gly Phe Tyr Gly Lys Met 130 His Tyr Thr Phe Tyr 210 His Gly Lys Asp Ala 290 Glu Tyr Ser Pro Gly 370 Asn Tyr Glu Met Asn Ile Glu Phe Phe 115 Ser Leu Leu Asn Leu 195 Ser Thr Leu Arg Leu 275 Asp Asn His Lys Phe 355 Gly Asp Ala Val Gin Arg Leu Pro Lys 100 Lys Ile Asn Ala Asn 180 Thr Val Val Ile Glu 260 Leu Asn Phe Pro Gln 340 Ile Val Asp Pro 5 Gin Lys Leu Phe Val Lys Lys Phe Pro Asn 165 Tyr Thr Phe Lys Phe 245 Ser Asp Asn Lys Thr 325 Cys Cys Lys Leu Lys Arg Gly Val Phe Gly 55 Val Thr 70 Leu Ile Asp Tyr Pro Phe Ser Met 135 Asn Arg 150 Asn Tyr Ser Leu Ser Lys Arg Asn 215 Lys Lys 230 Ser Asn Phe Tyr Thr Leu Phe Glu 295 Asp-Arg 310 Arg Leu Glu Phe Asn Arg Glu Val 375 Ser Glu 390 Gin Asn 40 Phe Ile Val Arg Leu 120 Lys Glu Glu Leu Lys 200 Phe Ile Asp Asp Asn 280 Glu Ile Lys Tyr Lys 360 Tyr Lys Phe 25 Pro Pro Val Ala Leu 105 Phe Pro Asp Cys Gly 185 Asp Val Val Phe Ile 265 Glu Phe Glu Glu Asn 345 Asp Phe Tyr 10 Gin Phe Glu Leu Ile 90 Tyr Lys Ser Arg Phe 170 Thr Leu Thr Ile Met 250 Ser Pro Gin Leu Tyr 330 Phe Leu Ala Phe Lys Phe Thr Ser 75 Val Gin Gly Lys Leu 155 Leu Ile Ile Pro Asp 235 Arg Phe Val Arg Ile 315 Thr Leu Tyr Asn Ser 395 Ile Lys Phe Val Ile Arg Val Glu 140 Val Asp Lys Glu Glu 220 Glu Ala Tyr Met Ile 300 Glu Lys Val Leu Lys 380 Ala Glu Val Ile Ile Val Met Lys 125 Met Ser Asp Leu Leu 205 Phe Thr Tyr Leu Asn 285 Ile Glu Asp Gly Lys 365 His Ile Glu Leu Tyr Leu Leu Glu 110 Asn Ala Ala Gly Gly 190 His Lys Asn Asn Thr 270 Lys Arg Leu Gly Met 350 Glu Gly Glu Leu Phe Ser Phe Val Arg Lys Asn Ala Val 175 Gly Ala Phe Arg Glu 255 Ile Lys Ala Leu Ile 335 Asn Lys Lys Ile Lys Asp Ser Gin Ala Ala Ala Asp Asn 160 Ile Ile Ser Tyr Asp 240 Lys Glu His Lys Ser 320 Ile Glu Met Ile Ser 400 Lys Ser Gin Ser Asp Leu Phe Asp Lys Ile Asn Ala Leu Asp Ser Giu Phe Ile Phe Met His Ala Tyr Ser Pro Lys Asn Ser 420 425 430 Gin Val Leu Lys Asp Lys Leu Ala Phe Thr Ser Arg Arg Ile Ile Ile 435 440 445 Ser Gly Gly Ser Lys Giu Gin Gly Met Thr Leu Gly Cys Leu Ser Giu 450 455 460 Leu Val Gly Asn Gly Asp Ile Thr Leu Gly Ser Tyr Gly Asn Ser Leu 465 470 475 480 Val Leu Phe Ala Asp Ser Phe Giu Lys Met Lys Gin Ser Val Lys Giu 485 490 495 Cys Val Ser Ser Leu Asn Ala Lys Gly Phe Leu Ala Asn Ala Ala Thr 500 505 510 Phe Ser Met Giu Asn Tyr Phe Phe Ala Lys His Cys Ser Phe Ile Thr 515 520 525 Leu Pro Phe Ile Phe Asp Val Thr Ser Asn Asn Phe Ala Asp Phe Ile 530 535 540 Ala Met Arg Ala Met Ser Phe Asp Gly Lys Giu Asp Asn Asn Ala Trp 545 550 555 560 Gly Asn Ser Val Met Thr Leu Lys Ser Giu Ile Asn Ser Pro Phe Tyr 565 570 575 Leu Asn Phe His Met Pro Thr Asp Phe Gly Ser Ala Ser Ala Gly His 580 585 590 Thr Leu Ilie Leu Gly Ser Thr Gly Ser Gly Lys Asn Ser Val Tyr Val 595 600 605 *His Asp Ser Lys Arg Tyr Gly Ala Ile Cys Leu 610 615 INFORMATION FOR SEQ ID NO:392: SEQUENCE CHARACTERISTICS: LENGTH: 110 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .110 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:392 Val Lys Thr Sen Cys Leu Val Th Ile Gly Arg Ile Arg Gly Val Phe 1 5 10 is Ile Ile Lys Ala Gin Leu Leu Leu Arg Glu Gly Gly Phe Met Asn Phe -25 Thr Ala Tyr Asn Thn Lys Thn Pro Gly His Leu His Leu Tyr Val His 40 Lys Gly His Thn Giu. Leu Gly Glu Gly Giu Arg Leu Ile Lys Thr Leu 55 Sen Met Lys Leu Ala Gin Gly Leu Pro Lys Glu Trp Arg Val Phe Pro 70 75 Ser Asn Glu Trp Pro Lys Glu Phe Asn Ile Leu Ala Leu Pro Tyr Glu 90 Val Phe Ala Lys Glu Ang Gly Sen Sen Tnp Ala Lys His Leu 100 105 110 INFORMATION FOR SEQ ID No:393: SEQUENCE CHARACTERISTICS: LENGTH: 68 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...68 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:393 Val Ala Lys Asp Ile Ile Ser Glu Ser Gin Asn Leu Cys Ala Arg Lys 1 5 10 Phe Arg Arg Leu Tyr Ala Leu Leu Lys Glu Asn Glu Met Leu Ile Arg 25 Ile Gly Ser Tyr Gin Met Gly Asn Asp Lys Glu Leu Asp Glu Ala Ile 40 Lys Lys Lys Ala Leu Met Glu Gin Phe Leu Val Gin Asp Glu Asn Ala 50 55 Leu Unk Ala Phe e INFORMATION FOR SEQ ID NO:394: 9 SEQUENCE CHARACTERISTICS: LENGTH: 446 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...446 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:394 Met Lys Ser Arg Pro Ile- Leu Ala Gin Ala Tyr Ala Leu Gin Met Met 1 5 10 Val Lys Gin Ile Ala Phe Leu Glu Thr Ile Leu Val Glu Asn Glu Gin 25 Asp Ala Leu Ile Leu Glu Asn Ser Leu Ile Lys Gin Leu Lys Pro Lys 40 Tyr Asn Ile Leu Leu Arg Asp Asp Lys Thr Tyr Pro Tyr Ile Tyr Met 55 Asp Phe Ser Ile Asp Phe Pro Ile Pro Leu Ile Thr Arg Lys Ile Leu 70 75 Lys Gin Pro Gly Val Lys Tyr Phe Gly Pro Phe Thr Ser Gly Ala Lys 90 Asp Ile Leu Asp Ser Leu Tyr Glu Leu Leu Pro Leu Val Gin Lys Lys 100 105 110 Asn Cys Ile Lys Asp Lys Lys Ala Cys Met Phe Tyr Gin le Giu Arg 115 120 125 Cys Lys Ala Pro Cys Giu Asp Lys Ile Thr Lys Glu Giu Tyr Leu Lys 130 135 140 Ile Ala Lys Giu Cys Leu Giu Met Ile Giu Asn Lys Asp Arg Leu Ile 145 150 155 160 Lys Giu Leu Giu Leu Lys Met Giu Arg Leu Ser Ser Asn Leu Arg Phe 165 170 175 Glu Giu Ala LeuIle Tyr Arg Asp Arg Ile Ala Lys Ile Gin Lys Ile 180 185 190 Ala Pro Phe Thr Cys Met Asp Leu Aia Lys Leu Tyr Asp Leu Asp Ile 195 200 205 Phe Ala Phe Tyr Giy Giy Asn Asn Lys Ala Val Leu Val Lys Met Phe 210 215 220 Met Arg Giy Gly Lys Ile Ile Ser Ser Ala Phe Giu Lys Ile His Ser 225 230 235 240 Leu Asn Gly Phe Asp Thr Asp Glu Ala Met Lys Gin Ala Ile Ile Asn 245 250 255 His Tyr Gin Ser His Leu Pro Leu Met Pro Giu Gin Ile Leu Leu Ser 260 265 270 Ala Cys Ser Asn Giu Thr Leu Lys Glu Leu Gin Giu Phe Ile Ser His 275 280 285 Gin Tyr Ser Lys Lys Ile Ala Leu Ser Ile Pro Lys Lys Giy Asp Lys 290 295 300 Leu Ala Leu Ile Giu Ile Ala Met Lys Asn Ala Gin Giu Ilie Phe Ser 305 310 315 320 Gin Glu Lys Thr Ser Asn Giu Asp Arg Ile Leu Giu Glu Ala Arg Ser 325 330 335 *Leu Phe Asn Leu Giu Cys Val Pro Tyr Arg Val Glu Ile Phe Asp Thr Se isHs340 345 350 Se i i Ser Asn Ser Gin Cys Val Gly Gly Met Val Val Tyr Giu 360 365 AAsn Ala Phe Gin Lys Asp Ser Tyr Arg Arg Tyr His Leu Lys Gly 370 375 380 Ser Asn Giu Tyr Asp Gin Met Ser Giu Leu Leu Thr Arg Arg Ala Leu 385 390 395 400 Asp Phe Ala Lys Giu Pro Pro Pro Asn Leu Trp Val Ile Asp Gly Gly 405 '410 415 Arg Ala Gin Leu Asn Ile Ala Leu Giu Ile Leu Lys Ser Ser Giy Ser 420 425 430 *Phe Val Giu Vai Ile Ala Ile Ser Lys Giu Lys Arg Gly Phe 435 440 445 INFORMATION FOR SEQ ID NO:39S: SEQUENCE CHARACTERISTICS: LENGTH: 84 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE:-protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .84 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:395 Val Sez- Leu Gly Ala Phe Gin Gly Tyr Tyr Gly Gly Leu Val Asp Leu 1 5 10 Val Gly Gin Arg Leu Ser Glu Ile Trp Ser Ala Ile Pro Met Leu Phe 25 Leu Leu Ile Val Ile Ser Ser Ala Phe Asn Ser Asn Phe Trp Ile Ile 40 Leu Phe Leu Val Leu Leu Phe Ser Trp Met Gly Leu Ser Gin Val Val 55 Arg Thr Glu Phe Leu Lys Ala Arg Asn Met Asp Tyr Thr Lys Ala Ala 70 75 Arg Ala Leu Gly INFORMATION FOR SEQ ID NO:396: SEQUENCE CHARACTERISTICS: LENGTH: 40 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori S(ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...40 xi) SEQUENCE DESCRIPTION: SEQ ID NO:396 Met Ser Glu Ala Tyr Phe Leu His His Lys Asn. Ala Ser Gin Val Ser 1 5 10 Leu Asn Glu Gin Val Leu Asn Val Met Lys Gin Val Gin Leu Asp Glu 20 25 Asn Phe Trp Asn Val Ser Leu Met INFORMATION FOR SEQ ID NO:397: SEQUENCE CHARACTERISTICS: LENGTH: 300 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...300 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:397 Val Ile Leu Ile Phe Ile Ile Val Val Glu Asp Gin Lys Gly Ile Phe 1 5 10 Pro Ile Ala Ala Ser Lys Arg Lys Ser Gin Ser Ser Val Ile Ile Glu 25 Asp Val Cys Phe Ser Lys Glu Asp Phe Val Glu Gly Ala Lys Ala Ile .1 Glu Gly Glu Phe Thr Ala Leu 145 Lys Met Leu Lys Glu 225 Cys Ile Ser Gly His Asn Leu Gly Tyr 130 Leu Asn Glu Thr Glu 210 Leu His Ala Lys Leu Ala Glu Met Arg 115 Lys Asn Leu Cys Pro 195 Arg Leu Met Leu Ile 275 Leu Leu Ala Val 100 Met Ile Pro Lys Gly 180 Arg Val Lys Cys Asn 260 Letu Lys Ser Glu Ser Val His Asp Ser 165 Phe Gin Ser Glu Ser 245 His SLys Lys Gly 70 Arg Lys Ala Lys Val 150 Ile Cys Arg His Ser 230 Thr STyr Ser His 55 Asn Lys Ser Pro Gin 135 Ile Tyr Glu Ile Gly 215 Glu Leu Gin His Gly I Leu Ala Ser Phe 120 Ile Ile Pro Arg Val 200 His Tyr Cys Lys Ala 280 Phe His Phe Gly 105 Val Lys Thr Ile Ile 185 Ile Asp Leu Pro Asr 265 Asr Lys Phe Glu 90 Ser Glu Glu Asn Glu 170 Cys His Glu Ala Leu 250 SPro SAsp Asp Val 75 Asn Ile Met Leu Asp 155 Glu Pro Arg Asp His 235 Gly Lys His Asn Gly Val Thr Leu Val Lys Ala Glu Trp 125 Phe Asp 140 Lys Glu His Leu Ser Lys Glu Val 205 Gin Val 220 Ala Thr Ile Asp Gly Glu Lys Arg 285 Ile Pro Ser Glu 110 Gly Pro Ile Asp Asp 190 Glu Leu Cys Thr Lys 270 Gly Ile Ile Glu His Glu Asn His Met 175 Leu Arg Leu Ala Gly 255 Ile Ser Phe Leu Met Gly Lys Gly Thr 160 Cys Ser Leu Asp Val 240 Unk Ala Phe r r r r Phe Phe 290 Lys Unk Arg Phe Arg Gly Phe Lys Asn 295 INFORMATION FOR SEQ ID NO:398: SEQUENCE CHARACTERISTICS: LENGTH: 214 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...214 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:398 Met Lys Glu Lys Asn Phe Trp Pro Leu Gly Ile Met Ser Val Leu Ile 1 5 10 Phe Gly Leu Gly Ile Val Val Phe Leu Val Val Phe Ala Leu Lys Asn 25 Ser Pro Lys Asn Asp Leu Val Tyr Phe Lys Gly His Asn Glu Val Asp 40 Leu Asn Phe Asn Ala Met Leu Lys Thr Tyr Glu Asn Phe Lys Ser Asn 55 Tyr Arg Phe Ser Val Gly Leu Lys Pro Leu Thr Glu Ser Pro Lys Thr 333 70 75 Pro Ile Leu Pro Tyr Phe Ser Lys Gly Thr His Gly Asp Lys Lys Ile 90 Gin Giu A-sn Leu Leu Asn Asn Ala Leu Ile Leu Giu Lys Ser Asn Thr 100 105 110 Leu Tyr Aia Gin Leu Gin Pro Leu Lys Pro Ala Leu Asp Ser Pro Asn 115 120 125 Ile Gin Vai Ty-r Leu Ala Phe Tyr Pro Ser Gin Ser Gin Pro Arg Leu 130 13S 140 Leu Gly Thr Leu Asp Cys Lys Asn Aia Cys Giu Pro Leu Lys Phe Asp 145 150 155 160 Leu Leu Glu Gly Asp Lys Vai Gly Arg Tyr Lys Ile Leu Phe Lys Phe 165 170 175 Val Phe Lys Asn Lys Giu Giu Leu Ile Leu Giu Gin Leu Leu Phe Leu 180 185 190 Ser Ser Met Ala Cys Met Gly Ile Ser Ile Leu Lys Asn Ala Lys Ala 195 200 205 Phe Phe Lys Tyr Lys Ile 210 INFORMATION FOR SEQ ID NO:399: SEQUENCE CHARACTERISTICS: LENGTH: 137 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .137 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:399 Met Pro Ile Lys Gly Ser Phe Leu Ala Arg Asn Arg Leu Val Ile Ala 1 5 10 Leu Thr Asp Ala Vai Ile Ile Pro Gin Ala Asp Leu Lys Sen Gly Ser 25 Met Ser Sen Ala Arg Leu Ala Gin Lys Tyr Gin Lys Pro Leu Phe Val 40 Lau Pro Gin Arg Leu Asn Giu Ser Asp Gly Thr Asn Giu Leu Leu Giu s0 55 Lys Giy Gin Ala Gin Gly Ile Phe Asn Ile Gin Asn Phe Ile Asn Thr 70 75 Leu Leu Lys Asp Tyr His- Leu Lys Glu Met Pro Giu Met Lys Asp Giu 90 Phe Leu Giu Tyr Cys Ala Lys Asn Pro Ser Tyr Giu Giu Ala Tyr Leu 100 105 110 Lys Phe Gly Asp Lys Leu Leu Giu Tyr Giu Leu Leu Giy Lys Ile Lys 115 120 125 Azg Ile Asn His Leu Val Val Leu Aia 130 135 INFORMA~TION FOR SEQ ID NO:400: SEQUENCE CHARACTERISTICS: LENGTH: 272 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .272 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:400 Met
I
His Gly Ile Val 65 Lys Val Thr Glu Gin 145 Leu Ile Val Met Glu 225 Ile Val Ala Val Asn Asn.
Ile Phe Lys Asp 130 Arg Cys Leu Phe Cys 210 Ile Lys Phe Leu le Cys Leu dly G lu Ile 115 Lys Val Asp Thr Ile 195 Val Phe Asn Leu 5 Lys Gly Gly Tyr Leu Glu Leu Asn Met Ile 85 Asn Val 100 Lys Ser Val His Ala Ile Glu Ala 165 Leu Leu 180 Thr His Ile Ser Ala Asn Glu His 245 Gly Giu 260 Val1 Ser Arg Leu 70 Phe Ala Arg Phe Ala 150 Thr Sen Gin Ser Pro 230 Ala His Asn Gly Pro 55 Lys Gin Phe Val1 135 Arg Sen Gly Ile G iy 215 Lys Asp Leu Leu Ala 40 Ser Pro His Ala His 120 Pro Ser Ala Ile Giu 200 Giu His Gin Asp Glu 25 G ly Ser Lys Phe Leu 105 Glu Lys Leu Leu Gin 185 Val Ile Ala Lys Giu 265 Val Val Giu Leu Lys Asn Ile Glu Lys 10 Leu Lys Gly Glu Asn 90 Giu Leu Gin Ala Asp 170 Lys Val1 Val1 Val Ser 250 Pro Lys Ser Glu Leu 75 Leu Ile Leu Leu As n 155 Ser Lys Glu Thr 235 Gin Ile Lys Thr Val1 Gin Leu Ala Giu Ser 140 Cys Lys Phe Giu Arg 220 Lys Asp Ile G ly Leu Leu Lys Ser Arg Leu 125 Gly Pro Thr Asp Leu 205 Gly Giu Ile Ser Asp Ile Val Ala Ala Tnp 110 Val1 Gly Asn Thr Leu 190 Cys Ser Leu Tyr Unk 270 Ile Tyr Glu Asn Gly is Ile Ang Asn Arg Lys Glu Gly Gin Leu His 175 Ser Asn Val Leu Arg 255 Phe Phe Leu Leu G ly Gin As n Lys Leu Lys Leu 160 Ser Ile Gin Glu Gly 240 Ile Unk INFORMATION FOR SEQ ID NO:401: SEQUENCE CHARACTERISTICS: (ii) (iii) (vi) LENGTH: 286 amino acids TYPE: amino acid TOPOLOGY: linear MOLECULE TYPE: protein HYPOTHETICAL: YES ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...286 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:401 Leu Unk Pro Met Lys Val Ile Gin Val Phe Leu Phe 9 9** a 99 a 1 Cys Ala His Asp Ala Gin Ser Lys Tyr Ile Leu Gly Ala Ser Ile Arg 130 Ile Leu 145 Pro Thr Leu Leu Tyr Ser Glu His 210 Val Lys 225 Thr Phe Val Asn Phe Gly Ile Leu Lys Asp Leu Ala Leu 115 Asn Gin Glu Asn Arg 195 Cys Arg Ile Asp Ala 275 Val Glu Arg Ala Lys Phe 100 Ala Asn Lys Ile Thr 180 Leu Asp Asp Asp Asn 260 Gly 5 Pro Arg Val Ile Asp Leu Ile Unk Asn Gly 165 Gin Met Arg Ile Arg 245 Val Asp Asn Phe Ile Val 70 Gly Val Leu Leu Asn 150 Unk Glu Asp Leu Asp 230 Val Val Ile Thr Phe Tyr 55 Leu Glu Trp Ser Asn 135 Leu Thr Lys Asn Ile 215 Leu Arg Glu Thr Glu Phe 40 Lys Glu Pro Gly Ala 120 Phe Ile Leu Ile Leu 200 Ile Lys Lys Thr Tyr 280 Pro 25 Ala Glu Lys Tyr Leu 105 Leu Lys Leu Lys Ile 185 Glu Leu Ala Lys Ile 265 Gin 10 Glu Tyr Asp Lys Thr 90 Gly Asp Gly Ile Ser 170 Val Glu Pro His Gly 250 Glu Leu His Lys Pro Asp 75 Ser Glu Glu Ile Asp 155 Ala Ile Phe Val Phe 235 Asp Lys Arg Leu Tyr Phe Ile Phe His Leu Lys 140 Asp Arg Trp Lys Tyr 220 Lys Phe Gly Gly Ser Glu Phe Leu Tyr Glu Asn Asn 125 Lys Tyr Ile Gin Lys 205 Ser His Leu Phe Glu 285 Asn His Leu Lys Asn Leu Ala 110 Leu Arg Ala Tyr Ala 190 Cys Ala Tyr Glu Val 270 Met Pro Phe Tyr Asp Asp His Asn Tyr Ile Gin Lys Asn Thr Asn Glu Glu Phe Asp His His 160 Ala Asn 175 His Lys Phe Leu Ser Glu Asn Pro 240 Leu Leu 255 Ile Gly INFORMATION FOR SEQ ID NO:401: SEQUENCE CHARACTERISTICS: LENGTH: 286 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...286 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:401 336 Leu 1 Cys His Ala Ser Tyr Leu Ala Ile Ile 145 Pro Leu Tyr Glu Val 225 Thr Val Phe Unk Ala Asp Gin Lys Ile Gly Ser Arg 130 Leu Thr Leu Ser His 210 Lys Phe Asn Gly Pro Ile Leu Lys Asp Leu Ala Leu 115 Asn Gin Glu Asn Arg 195 Cys Arg Ile Asp Ala 275 Met Val Glu Arg Ala Lys Phe 100 Ala Asn Lys Ile Thr 180 Leu Asp Asp Asp Asn 260 Gly Lys 5 Pro Arg Val Ile Asp Leu Ile Unk Asn Gly 165 Gin Met Arg Ile Arg 245 Val Asp Val Ile Gin Val Phe Leu Phe Ser Asn Pro Phe Asn Phe Ile Val 70 Gly Val Leu Leu Asn 150 Unk Glu Asp Leu Asp 230 Val Val Ile Thr Phe Tyr 55 Leu Glu Trp Ser Asn 135 Leu Thr Lys Asn Ile 215 Leu Arg Glu Thr Glu Phe 40 Lys Glu Pro Gly Ala 120 Phe Ile Leu Ile Leu 200 lie Lys Lys Thr Tyr 280 Pro 25 Ala Glu Lys Tyr Leu 105 Leu Lys Leu Lys le 185 Glu Leu Ala Lys Ile 265 Gin 10 Glu Tyr Asp Lys Thr 90 Gly Asp Gly Ile Ser 170 Val Glu Pro His Gly 250 Glu Leu His Lys Pro Asp 75 Ser Glu Glu Ile Asp 155 Ala Ile Phe Val Phe 235 Asp Lys Arg Leu Tyr Phe Ile Phe His Leu Lys 140 Asp Arg Trp Lys Tyr 220 Lys Phe Gly Gly Glu Phe Leu Tyr Glu Asn Asn 125 Lys Tyr Ile Gin Lys 205 Ser His Leu Phe Glu 285 His Tyr Leu Asp Lys Asn Asn Ile Leu Lys Ala Thr 110 Leu Glu Arg Phe Ala His Tyr Ala 175 Ala His 190 Cys Phe Ala Ser Tyr Asn Glu Leu 255 Val Ile 270 Met Asp His Tyr Gin Asn Asn Glu Asp His 160 Asn Lys Leu Glu Pro 240 Leu Gly
U.
U
U.
INFORMATION FOR SEQ ID NO:402: SEQUENCE CHARACTERISTICS: LENGTH: 106 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...106 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:402 Met Gly Ala Leu Ile Ala Met Phe Phe Leu Met Leu Ile Lys Lys Thr 1 5 10 Ile Ala Tyr Lys Glu Asp Lys Lys Ser Ala Ala Leu Lys Val Val Pro 25 Tyr Leu Val Ala Leu Met Ser Leu Ala Phe Ser Trp Tyr Leu Ile Val 40 Lys Val Leu Lys Arg Leu Tyr Ala Val Ser Phe Glu Ile Gln Leu Ala 55 Cys Gly Cys Val Leu Ala Leu Leu Ile Phe Ile Leu Phe Lys Arg Phe 70 75 Val Leu Lys Lys Ala Pro Gin Leu Glu Asn Ser His Glu Ser Val Asn 90 Glu Leu Phe Asn Val Pro Leu Ile Phe Ala 100 105 INFORMATION FOR SEQ ID NO:403: SEQUENCE CHARACTERISTICS: LENGTH: 157 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...157 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:403 Met Ile Lys Arg Ile Ala Cys Ile Leu Ser Leu Ser Ala Ser Leu Ala 1 5 10 Leu Ala Gly Glu Val Asn Gly Phe Phe Met Gly Ala Gly Tyr Gin Gin 25 Gly Arg Tyr Gly Pro Tyr Asn Ser Asn Tyr Ser Asp Trp Arg His Gly 35 40 Asn Asp Leu Tyr Gly Leu Asn Phe Lys Leu Gly Phe Val Gly Phe Ala 50 55 Asn Lys Trp Phe Gly Ala Arg Val Tyr Gly Phe Leu Asp Trp Phe Asn 70 75 Thr Ser Gly Thr Glu His Thr Lys Thr Asn Leu Leu Thr Tyr Gly Gly 85 90 Gly Gly Asp Leu Ile Val Asn Leu Ile Pro Leu Asp Lys Phe Ala Leu 100 105 110 Gly Leu Ile Gly Gly Val Gin Leu Ala Gly Asn Thr Trp Met Phe Pro S115 120 125 Tyr Asp Val Asn Gin Thr Arg Phe Gin Phe Leu Trp Asn Leu Gly Gly 130 135 140 Arg Met Arg Val Gly Asp Thr Val Arg Leu Lys Arg Ala 145 150 155 INFORMATION FOR SEQ ID NO:404: SEQUENCE CHARACTERISTICS: LENGTH: 278 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .278 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:404 Met Tyr Arg His Val Leu Lys Asp Phe Ser Leu 1 Ser Leu Val1 Phe Lys Phe His Lys Ala 145 Lys Asn Thr Asn.
Val 225 Lys Leu Glu Val1 Leu Leu Ser Lys Phe Ala Ala 130 Phe Met Pro Asn Pro 210 Pro G 1y Ala Giu Gln Pro Gin Lys Ile Leu Ala 115 Leu Val1 Thr Giu Lys 195 Thr Val1 Ile Arg Leu 275 Glu Val Phe Ile Leu Gly 100 Leu Trp Asp Lys Ile 180 Met His Val1 Ala Giu 260 Phe 5 Leu Leu Gly Asri Asp Phe Leu Leu Leu Gin 165 Lys Met Tyr Val Arg 245 Leu Giu Phe Ile Trp Pro 70 Gly Phe Asn Ile Ile
ISO
Giu Ala Gin Ala Ala 230 Glu Tyr Arg Asn Ile Leu 55 Ile Ser Ile Leu Ser 135 Ile Val1 Lys G lu Val1 215 Lys His Arg Gin Leu 40 Phe Asn Leu Phe Gin 120 Ser Lys Lys Ile Ile 200 Ala G ly Asp Asp 10 Leu Ala 25 Met Val Ala Pro Gly Val Ile Thr 90 Ser Leu 105 Gly Gin Leu Leu Arg Arg Asp Giu 170 Arg Gin 185 Pro Lys Leu Lys Thr Asp Ile Glu 250 Val Lys 265 Lys Val1 Lys Lys 75 Leu Phe Leu Phe Gin i55 Tyr Met Ser Phe Tyr 235 Ile Leu Asp Asp Ala Val1 Asn Lys Leu Leu Leu 140 Tyr Lys Met Asn Asp 220 Leu Ile Asn Phe Thr Phe Ile Leu Val1 G ly Trp 125 Phe Thr Gin Val Val1 205 Glu Ala Glu Ala Ser Phe Leu Giu Phe Phe Giu 110 Phe Phe As n Gin Lys 190 Val1 Glu Ile Asn Thr 270 Lys Leu Ser Pro Ser Leu Leu Lys Val Ser Glu 175 Asn Val His Arg Lys 255 Ile Glu Leu As n Lys Leu Ala As n Ser Leu Leu 160 Gly Ala Thr Pro Ile 240 Thr Pro p.
a a. a a.
a. a a .6.
6 INFORMATION FOR SEQ ID NO:405: SEQUENCE CHARACTERISTICS: LENGTH: 120 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPEI protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 120 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:405 Met Asn Thr Unk Pro Leu Ile Ala Thr Leu Leu Gin Ala Pro Leu His 339 1 5 10 Val Leu Gly Ile Arg Glu Pro Val Ser Phe Gin Pro Phe Tyr Pro Lys 25 Thr Glu Lys Pro Asn Arg Pro Gin Lys Phe Ala His Val Ser Ser Met 40 Pro Ser Leu Glu Phe Leu Glu Lys Leu Val Ile Arg Tyr Leu Leu Glu 55 Asp Arg Ser Leu Leu Asp Leu Ala Val Gly Tyr Ile His Ser Gly Val 70 75 Phe Leu His Lys Lys Gin Glu Phe Asp Ala Leu Cys Gin Glu Lys Leu 90 Asp Asp Pro Lys Leu Val Ala Leu Leu Leu Asp Ala Asn Leu Pro Leu 100 105 110 Lys Lys Gly Gly Phe Glu Lys Glu 115 120 INFORMATION FOR SEQ ID NO:406: SEQUENCE CHARACTERISTICS: LENGTH: 226 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein 0** (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: a ORGANISM: Helicobacter pylori (ix) FEATURE: S(A) NAME/KEY: misc_feature LOCATION 1...226 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:406 Met Gly Gin Ala Phe Phe Lys Lys Ile Val Gly Cys Phe Cys Leu Gly 1 5 10 Tyr Leu Phe Leu Ser Ser Ala Ile Glu Ala Val Ala Leu Asp Ile Lys 20 25 Asn Phe Asn Arg Gly Arg Val Lys Val Val Asn Lys Lys Ile Ala Tyr 40 Leu Gly Asp Glu Lys Pro Ile Thr Ile Trp Thr Ser Leu Asp Asn Val 55 Thr Val Ile Gin Leu Glu Lys Asp Glu Thr Ile Ser Tyr Ile Thr Thr S65 70 75 Gly Phe Asn Lys Gly Trp Ser Ile Val Pro Asn Ser Asn His Ile Phe 90 Ile Gin Pro Lys Ser Val Lys Ser Asn Leu Met Phe Glu Lys Glu Ala 100 105 110 Val Asn Phe Ala Leu Met Thr Arg Asp Tyr Gin Glu Phe Leu Lys Thr 115 120 125 Lys Lys Leu Ile Val Asp Ala Pro Asp Pro Lys Glu Leu Glu Glu Gin 130 135 140 Lys Lys Ala Leu Glu Lys Glu Lys Glu Ala Lys Glu Gin Ala Gin Lys 145 150 155 160 Ala Gin Lys Asp Lys Arg Glu Lys Arg Lys Glu Glu Arg Ala Lys Asn 165 170 175 Arg Ala Asn Leu Glu Asn Leu Thr Asn Ala Met Ser Asn Pro Gin Asn 180 185 190 Leu Ser Asn Asn Lys Asn Leu Ser Glu Leu Ile Lys Gin Gin Arg Glu 195 200 205 Asn Glu Leu Asp Gin Met Glu Arg Thr Arg Gly His Ala Arg Ala Gly 210 215 220 Ser Ser 225 INFORMATION FOR SEQ ID NO:407: SEQUENCE CHARACTERISTICS: LENGTH: 61 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...61 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:407 .too Leu Leu Leu Phe Phe Leu Leu Lys Gly Val Val Phe Ser Leu Gly Phe 1 5 10 Phe Ser Phe Phe Glu Glu Val Ser Gly Ser Phe Unk Ala Val Ser Leu 25 S" Unk Val Leu Ala Leu Val Met Gly Ser Ser Unk Gly Leu Glu Glu Phe 35 40 Cys Val Leu Glu Glu Leu Ile Asn Ser Gly Leu Ser Val 50 55 INFORMATION FOR SEQ ID NO:407: S0 SEQUENCE CHARACTERISTICS: LENGTH: 61 amino acids TYPE: amino acid e, TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES
I.
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc feature LOCATION 1...61 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:407 Leu Leu Leu Phe Phe Leu Leu Lys Gly Val Val Phe Ser Leu Gly Phe 1 5 10 Phe Ser Phe Phe Glu Glu Val Ser Gly Ser Phe Unk Ala Val Ser Leu 25 Unk Val Leu Ala Leu Val Met Gly Ser Ser Unk Gly Leu Glu Glu Phe 40 Cys Val Leu Glu Glu Leu Ile Asn Ser Gly Leu Ser Val 55 INFORMATION FOR SEQ ID NO:408: SEQUENCE CHARACTERISTICS: LENGTH: 50 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc feature LOCATION 1...50 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:408 Met Asn Thr Glu Ile Leu Thr Ile Met Leu Val Val Ser Val Leu Met 1 5 10 Gly Leu Val Gly Leu Ile Ala Phe Leu Trp Gly Val Lys Ser Gly Gin 25 Phe Asp Asp Glu Lys Arg Met Leu Glu Ser Val Leu Tyr Asp Ala Arg 40 Ala Thr INFORMATION FOR SEQ ID NO:409: SEQUENCE CHARACTERISTICS: LENGTH: 122 amino acids TYPE: amino acid TOPOLOGY: linear MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori S (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...122 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:409 Met Gly Phe Leu Lys Val Leu Lys His Asp Ala Leu Gly Gin Val Gly 1 5 10 Asn Ile Val Ile Gly Asn Phe Leu Ile Thr Leu Thr Val Leu Ala Val 25 Cys Phe Ser Ser Gin Ser Ala Glu Glu Thr Thr Met Leu Thr Leu Ser 40 Tyr Thr Leu Phe Phe Ile Leu Gly Ala Phe Leu Leu Val Ala Ile Ser 55 Val Gly Ala Ile Lys Asn Leu Asn Ala Leu Phe Ser Lys Arg Gly Val 70 75 Leu Ser Phe Ser Leu Pro Ile Ser Leu Glu Ser Leu Leu Leu Pro Lys 90 Ile Leu Leu Pro Unk Val Phe Phe Tyr Leu Gin Phe Val Leu Val Cys 100 105 110 Gly Glu Arg Ala Phe Gly Leu Leu Pro Phe 115 120 INFORMATION FOR SEQ ID NO:409: SEQUENCE CHARACTERISTICS: LENGTH: 122 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...122 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:409 Met Gly Phe Leu Lys Val Leu Lys His Asp Ala Leu Gly Gin Val Gly 1 5 10 Asn Ile Val Ile Gly Asn Phe Leu Ile Thr Leu Thr Val Leu Ala Val 25 Cys Phe Ser Ser Gln Ser Ala Glu Glu Thr Thr Met Leu Thr Leu Ser 40 Tyr Thr Leu Phe Phe Ile Leu Gly Ala Phe Leu Leu Val Ala Ile Ser 55 S* Val Gly Ala Ile Lys Asn Leu Asn Ala Leu Phe Ser Lys Arg Gly Val 70 75 Leu Ser Phe Ser Leu Pro Ile Ser Leu Glu Ser Leu Leu Leu Pro Lys 85 90 Ile Leu Leu Pro Unk Val Phe Phe Tyr Leu Gin Phe Val Leu Val Cys 100 105 110 Gly Glu Arg Ala Phe Gly Leu Leu Pro Phe 115 120 INFORMATION FOR SEQ ID NO:410: SEQUENCE CHARACTERISTICS: LENGTH: 187 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...187 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:410 Met Leu Lys Thr His Leu Ser Ser Ala Arg Gly Val Val Val Leu Ser 1 5 10 Lys Ile Leu Pro Val Asn Val Val Leu Met Val Ser Val Arg Leu Phe 25 Glu Lys Glu Leu Lys Arg Lys Pro Tyr Tyr Ile Ile Ala Ser Ala His Ser tink Cys Asp Leu Ala Pro 145 Gly Gin Asp Unk Unk Thr Val Phe 130 Asp Thr Lys Giu Pro Leu Leu Leu 115 Val Gly Ser Pro Gly Thr Asp Leu 100 Arg Ile Glu Glu Lys 180 Unk Val1 Arg Val1 Phe Gly Ser 155 Gin Leu INFORMATION FOR SEQ ID NO:410: SEQUENCE CHARACTERISTICS: LENGTH: i87 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .187 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:410 Met Leu 1 Lys Ile Glu Lys Ser Asp Unk Unk Cys Unk Asp Thr Leu Val Ala Phe 130 Pro Asp 145 Gly Thr Lys Thr His Leu Sen Sen Ala Arg Gly Val Leu Glu 35 Glu Pro Leu Leu Leu 115 Val Gly Sen Pro Leu Gly Thr Asp Leu 100 Arg Ile Glu Glu
LYS
180 Val Asn Lys Arg Leu Giu Lys Leu 70 Met Giu Asp Leu Lys Leu Gly Ile Thr Ile 150 Gly Vai 165 Leu 25 Tyr Lys Gin Leu Val1 105 Ala Lys Sen Cys Val Ile Unk Vali Arg Val Phe Gly Ser 155 Gin Val1 Val1 Ala Unk Ala Ile Lys Giu 125 Tyr Leu Ile Val1 Arg Ser Asp Asn As n Thr 110 Ile Ile Leu Thr Gin Lys Pro Giu Val Asp Tyr Ile Ser Leu INFORMATION FOR SEQ ID NO:411: SEQUENCE CHARACTERISTICS: LENGTH: 130 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...130 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:411 Met Phe Val Ala Ala Gly Leu Gly Ala Tyr Ala Ile Ala Leu Phe His 1 5 10 Leu Phe Thr His Ala Phe Phe Lys Ser Leu Leu Phe Leu Gly Ser Gly 25 Asn Val Met His Ala Met Glu Asp Asn Leu Asp Ile Thr Lys Met Gly 35 40 Ala Leu Tyr Lys Pro Met Arg Ile Thr Ala Val Phe Met Ile Ile Gly 50 55 Ser Val Ala Leu Cys Gly Ile Tyr Pro Phe Ala Gly Tyr Phe Ser Lys 65 70 75 Asp Lys Ile Leu Glu Val Ala Phe Gly Met His His His Ile Leu Trp 85 90 Phe Val Leu Leu Ile Gly Ala Ile Phe Thr Ala Phe Tyr Ser Phe Arg 100 105 110 Leu Ile Met Leu Val Phe Phe Ala Pro Lys Gin His Glu Ile Asn His 115 120 125 Pro Pro 130 INFORMATION FOR SEQ ID NO:412: SEQUENCE CHARACTERISTICS: LENGTH: 183 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...183 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:412 Met Phe Ile Ser Ser Ser Tyr Thr Leu Ser Phe Val Trp Leu Phe Leu 1 5 10 Ile Phe Phe Phe Phe Lys Asn Lys Pro Leu Gly Leu Arg Phe Ser Leu 25 Ser Leu Ile Ser Val Ile Leu Ser Asn Ile Ala Leu Lys Asp Ser Leu 40 Ser Leu Asn Glu Phe Leu Ser Ser phe Thr Ala Pro Leu Ser Pro Phe so 55 Ser Cys Leu Leu Ile Leu Ala Tyr Ala Ser Phe Ser Cys His Ile Leu 70 75 Lys Lys Pro Pro Leu Giu Thr Leu Gin Ser Tyr Ser Val Met Leu Phe 90 Phe Asn Leu Leu Leu Leu Thr Asp Ile Leu Gly Phe Leu Pro Phe Ser 100 105 110 Ile Tyr His His Phe Met Ala Ser Leu Ile Phe Ser Ala Leu Phe Cys 115 120 125 Ser Ser Leu Phe Leu Ser Ser Pro Leu Leu Gly Val Ile Ala Leu Val 130 135 140 Ala Leu Ser Ser Ser Leu Leu Met Arg Ser Asn Phe Gin Ile Leu Asp 145 150 155 160 Ser Leu Leu Asp Phe Pro Leu Phe Leu Phe Val Phe Phe Lys Thr Leu 165 170 175 Tyr Leu Ala Lys Lys Arg Leu 180 INFORMATION FOR SEQ ID NO:413: SEQUENCE CHARACTERISTICS: LENGTH: 193 amino acids TYPE: amino acid, TOPOLOGY: linear (ii) MOLECULE TYPE: protein :**too (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .193 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:413 'Off**Val Gly Sen Phe Leu Phe Val Gly Pro Sen Gly Val Gly Lys Thr Glu 1 5 10 Leu Ala Lys Glu Leu Ala Leu Asn Leu Unk Leu His Phe Giu Arg Phe :20 25 Asp Met Ser Giu Tyr Lys Giu Ala His Sen Val Ala Lys Leu Ile Gly 40 Ser Pro Ser Gly Tyr Val Gly Phe Giu Gin Gly Gly Leu Leu Val Asn 55 Ala Ile Lys Lys His Pro His Cys Leu Leu Leu Leu Asp Giu Ile Giu 70 75 Lys Ala His Pro Asn Val Tyr Asp Leu Leu Leu Gin Val Met Unk Asn 90 Ala Thr Leu Ser Asp Asn Leu Gly Asn Lys Ala Ser Phe Lys His Val 100 1OS 110 Ile Leu Ile Met Thr Unk Unk Val Gly Ser Lys Asp Lys Asp Thr Leu 11S 120 125 Gly Phe Phe Ser Thr Lys Asn Ala Lys Tyr Asp Arg Ala Val Lys Glu 130 135 140 Leu Leu Thr Pro Glu Leu Ang Sen Ang Ile Asp Ala Ile Val Pro Phe 145 150 155 160 Asn Ala Leu Ser Leu Glu Asp Phe Giu Thr His Cys Phe Cys Gly Ile 165 170 175 346 Gly Arg Val Lys Ser Pro Ser Thr Arg Ala Arg Arg Asp Leu Lys Ile 180 185 190 Pro INFORMATION FOR SEQ ID NO:413: SEQUENCE CHARACTERISTICS: LENGTH: 193 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...193 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:413 Val Gly Ser Phe Leu Phe Val Gly Pro Ser Gly Val Gly Lys Thr Glu 1 5 10 Leu Ala Lys Glu Leu Ala Leu Asn Leu Unk Leu His Phe Glu Arg Phe 20 25 .4 Asp Met Ser Glu Tyr Lys Glu Ala His Ser Val Ala Lys Leu Ile Gly 40 Ser Pro Ser Gly Tyr Val Gly Phe Glu Gln Gly Gly Leu Leu Val Asn 50 55 Ala Ile Lys Lys His Pro His Cys Leu Leu Leu Leu Asp Glu Ile Glu 70 75 Lys Ala His Pro Asn Val Tyr Asp Leu Leu Leu Gln Val Met Unk Asn Ala 85 90 SAla Thr Leu Ser Asp Asn Leu Gly Asn Lys Ala Ser Phe Lys His Val 100 105 110 Ile Leu Ile Met Thr Unk Unk Val Gly Ser Lys Asp Lys Asp Thr Leu 115 120 125 Gly Phe Phe Ser Thr Lys Asn Ala Lys Tyr Asp Arg Ala Val Lys Glu 130 135 140 Leu Leu Thr Pro Glu Leu Arg Ser Arg Ile Asp Ala Ile Val Pro Phe 145 150 155 160 Asn Ala Leu Ser Leu Glu Asp Phe Glu Thr His Cys Phe Cys Gly Ile 165 170 175 Gly Arg Val Lys Ser Pro Ser Thr Arg Ala Arg Arg Asp Leu Lys Ile 180 185 190 Pro INFORMATION FOR SEQ ID NO:414: SEQUENCE CHARACTERISTICS: LENGTH: 235 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .235 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:4l4 Met Arg Leu Asp Tyr Ala Leu Phe Asn Gin His Leu Ala Asn Ser Arg Glu Met Giu G ly Leu Lys Asp Asp Asp 145 Leu Arg Ile Phe Asn 225 Lys Val Leu Ala Asp G ly Glu Ile 130 Val Ser Thr Leu Gin 210 Val Ala Val Ile Phe Val Ala Ser 115 Arg Ser Glv Ile Asia 195 Ile Glu Lys Ser Ala Leu Gly Lys 100 Leu Gly Phe Glu Lys 180 Ala Leu Phe Ala Lys Pro Glu Ala Lys Lys Phe Ile Phe 165 Arg Leu Thr Phe Leu Pro Asn Asp 70 Ser Val1 Asn Lys Ser 150 Leu As n G iu Ile Ile 230 Val1 Se r Leu His Lys Leu Asp Thr 135 Leu Thr Lys Asn Gin 215 His Leu Phe 40 Phe Phe G ly Cys Gin 120 Pro Tyr Leu Lys Phe 200 Giu Phe Lys 25 Ile Val1 Ile Gly Val1 105 Arg G iu Cys Phe Gly 185 Lys Sen Lys 10 Lys Gin Val Lys Ser Arg Asp Phe 75 Phe Ser 90 Asp Vai Ile Giu Lys Ile Ile Leu 155 Lys Pro 170 Val Val Asn His Leu Val Arg Ala Leu Gly Gly Giu Val1 Lys 125 Leu Ala Phe Asp Lys 205 Giy Val1 Asp Giu Lys Ala Met 110 Glu Ala Ile Glu Lys 190 Thn Lys As n Gin Lys Val1 Leu Gin G iu Leu Leu Val1 175 Giu Lys Asia Lys Ile Leu Val1 Leu Leu Cys Cys Pro 160 Gly Ala Asp Gly
WA
A
A. INFORMATION FOR SEQ ID NO:415:
A
SEQUENCE CHARACTERISTICS: LENGTH: 88 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .88 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:4iS Met Ser Leu Pro Pro Val Cys Ile Leu Lys Asp Val Asn His Leu Leu 10 Gin Val Leu His Ser Leu Val Ala Leu Gly Asn Sen Met Leu Val Ile 25 348 Glu His Asn Leu Asp Ile Ile Lys Asn Ala Asp Tyr Ile Ile Asp Met 40 Gly Pro Asp Gly Gly Asp Lys Gly Gly Lys Val Ile Ala Ser Gly Thr 55 Pro Leu Glu Val Ala Gin Asn Cys Glu Lys Thr Gin Ser Tyr Thr Gly 70 75 Lys Phe Leu Ala Leu Glu Leu Lys INFORMATION FOR SEQ ID NO:416: SEQUENCE CHARACTERISTICS: LENGTH: 109 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...109 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:416 Met Gin Asn Arg Ser His Glu Ile Gin Gly Val Ser His Ile Lys Asn 1 5 10 Asn Tyr Lys Phe Phe Thr Lys Glu Leu Asp Asn Tyr Ile Ser Lys Gly 20 25 Tyr Arg Ile Glu Glu Ile Tyr Gly Ala Phe Leu Trp Leu Lys Ile Val 35 40 Ala Ile Gly Leu Glu Leu Gly Glu Asp Asp Pro Gin Val Val Phe Glu 55 Ser Ile Asn Ala Thr Gly Val Gin Leu Lys Gly Leu Asp Leu Ile Arg 70 75 Asn Tyr Leu Met Met Gly Glu Asn Unk Asp Asn Gin Asn Arg Leu Tyr 90 Asn Thr Tyr Trp Val Pro Leu Glu Asn Trp Leu Gly Glu 100 105 INFORMATION FOR SEQ ID NO:417: SEQUENCE CHARACTERISTICS: LENGTH: 107 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...107 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:417 Met Asp Thr Ile Lys Ser Ile Pro Ile Arg Thr Phe Ile Leu Leu Tyr 1 5 10 Lys Ser Ser Pro Lys Cys Val Val Leu Ala Ser Ile Thr Val Leu Phe 25 Val Gly Ile Leu Unk Ser Leu Asn Ile Leu Val Met Ile Lys Leu Ile 40 Asp Ile Val Val Asn Leu Leu Gin Lys His Thr His Phe Glu Tyr Ser 55 Leu Leu Leu Pro Thr Leu Leu Leu Trp Gly Ala Leu Leu Phe Leu Thr 70 75 His Val Phe Ser Gly Asn Phe Ile Lys Leu Ala Asn His Tyr Cys Arg 90 Thr Ile Phe Tyr Lys Tyr His His Ser Ala Cys 100 105 INFORMATION FOR SEQ ID NO:418: SEQUENCE CHARACTERISTICS: LENGTH: 136 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...136 S* (xi) SEQUENCE DESCRIPTION: SEQ ID NO:418 Met Ile Phe Tyr Thr Thr Ile Lys Glu Pro Leu Lys Asn Leu Gin Tyr 1 5 10 Arg Tyr Ala Gin Phe Phe Gly Lys Ile Lys Pro Cys Ser Phe Leu Glu 25 Ser Leu Lys Ser Cys Phe Phe Gin Thr Tyr Ser Phe Ser Leu Thr Arg 40 Lys Gin Asp Phe Lys Ser His Leu Arg His Phe Ile Asp Ser Ala His 55 Ser Asn Ala Leu Val Gly Asn Leu Tyr Arg Ala Leu Phe Ile Gly Asp 70 75 Ser Leu Asn Lys Asp Leu Arg Asp Arg Ala Asn Ala Leu Gly Ile Asn 90 His Leu Leu Ala Ile Ser Gly Phe His Leu Gly Ile Leu Ser Ala Ser 100 105 110 Val Tyr Phe Leu Phe Ser Leu Phe Tyr Thr Pro Leu Gin Lys Arg Tyr 115 120 125 Phe Pro Tyr Arg Asn Ala Phe Unk 130 135 INFORMATION FOR SEQ ID NO:419: SEQUENCE CHARACTERISTICS: LENGTH: 54 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...54 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:419 Met Asn Lys Pro Phe Leu Ile Leu Leu Ile Ala Leu Ile Ala Phe Ser 1 5 10 Gly Cys Asn Met Arg Lys Tyr Phe Lys Pro Ala Lys His Gin Ile Lys 25 Ala Lys Arg Ile Ser Leu Thr Ile Cys Lys Lys Ala Ser Phe Arg Leu 40 Ile Val Met Glu Pro Phe INFORMATION FOR SEQ ID NO:420: SEQUENCE CHARACTERISTICS: LENGTH: 125 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...125 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:420 Met Ala Ala Trp Asn Thr Leu Val Glu Lys Ile Ile Ala Pro Lys His 1 5 10 I: Lys Val Lys Ile Gly Phe Val Gly Lys Tyr Leu Ser Leu Lys Glu Ser 20 25 Tyr Lys Ser Leu Ile Glu Ala Leu Ile His Ala Gly Ala His Leu Asp 40 Thr Gln Val Asn Ile Glu Trp Leu Asp Ser Glu Asn Phe Asn Glu Lys 55 Thr Asp Leu Glu Gly Val Asp Ala Ile Leu Val Pro Gly Gly Phe Gly 70- 75 Glu Arg Gly Ile Glu Gly Lys Ile Cys Ala Ile Gin Arg Ala Arg Leu 90 Glu Lys Leu Pro Phe Leu Gly Ile Cys Leu Gly Met Gin Leu Ala Ile 100 105 110 Val Glu Phe Cys Arg Lys Cys Phe Arg Leu Glu Arg Gly 115 120 125 INFORMATION FOR SEQ ID NO:421: SEQUENCE CHARACTERISTICS: LENGTH: 249 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL; YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .249 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:42i Met Leu Gly Gly Thr Leu Gin Thr Arg Gly 145 Asn Phe Pro Gly Met 225 Phe Ala Phe Glu G lu Ser Asn Gin Asn 130 Thr Lys Pro Arg Val 210 Th r Arg Phe Leu Phe Asn Gin Gly Gly 115 Lys Asp Asn Leu Phe 195 T'yr Phe Lys Leu Gin Gin Ser Ser Phe Lys Lys Leu Lys 165 Ser Thr Leu Phe Ile 245 Pro Lys Asp Leu Ala Leu 105 Val1 Ser Lys Ser Ile 185 Tyr Val Trp Tyr 10 Thr Ile Trp Val Gin 90 Tyr Asp Asn Lys Gin 170 Pro Phe Ile Ala Ser Asp Leu Leu 75 Lys Asn Phe Asp Ala.
155 Ala Leu Unk Ser Phe 235 Thr Lys Ala Phe Val Pro Leu Ser Leu Leu Val Ser Ser Asn Tyr Ser Asn His Giu 125 Ala Gly Leu Gly Leu 205 Asp Ser Ala Ala Ile Val Asn Ile Ala 110 Leu Tyr Lys Vali Ile 190 Gly Leu Tyr Ile Leu Tyr Tyr Arg Ala Asp Lys Lys Ser Asn Asn Tyr Phe His Leu Leu Gin Asn Ala 160 Ser Leu 175 Ala Asn Ala Val Phe Leu Leu Leu 240
C
INFORMATION
SEQUEN
FOR SEQ ID NO:422: CE CHARACTERISTICS: LENGTH: 86 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature Met Leu Glu Ile Ile Arg LOCATION .86 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:422 Ser Lys Ser Ala Ile Phe Val Leu Ser Gly Phe Leu Ala Phe 10 Tyr Ala Leu Leu Leu Tyr Gly Leu Leu Leu Giu Arg His Asn 25 Ala Giu Lys Ile Leu Leu Asp Leu Asn Lys Lys Asp Giu Gin 40 Asp Leu Asn Leu Glu Asp Leu Pro Ser Giu Lys Lys Asn Giu 55 Lys Lys Val Thr Giu Lys Gin Asp Asp Phe Leu Glu Pro Lys 70 Thr Gin Arg Gly Ala INFORMATION FOR SEQ ID NO:423: SEQUENCE CHARACTERISTICS: LENGTH: 128 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .128 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:423 a a a S a
S
a..
*a as a Val Met Ala Gin Sen Leu Leu Leu Ile Leu 50 Gin Leu Ile Leu Ala Gin 35 Leu Phe Met Thr Tyr 115 Met Asn Ile Phe Ile Lys Leu Ile Arg Ala Ser Ala Glu Giu Val Leu Ile Leu Ser Ile Met Ile 120 His Tyr Tyr Ser Ala Lys Lys 105 Leu Phe' Phe Leu Phe Val Met Val Phe Val Met His Lys Tyr Ile Ile Val INFORMATION FOR SEQ ID NO:424: SEQUENCE CHARACTERISTICS: LENGTH: 93 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .93 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:424 Val Arg Asn Val Vai Leu Phe Ile Leu Thr Ala Ile 1 5 10 Met Leu Leu Vai Ser Tyr Cys Met Pro His Tyr Ser 25 Ser Gly Val Giu Val Lys Arg Met Asn Giu Asn Giu 40 Asn Lys Giu Vai Lys Thr Leu Ala Arg Asp Val Tyr 55 Tyr Asp Pro Lys Asp Gin Lys Sen Val Thr Val Tyr 70 75 Thr Arg Phe Gly Phe Pro Phe Tyr Phe Lys Phe Asn Phe Leu Ala Phe is Vai Ala Vai Ile Asn Thr Pro Asn Phe Val Gin Thr Arg Asri Giu Asp Ser
C..
C C 0b C *9 Cb C C C. C C C. C
CCC.
C
C.
C INFORMATION FOR SEQ ID NO:425: SEQUENCE CHARACTERISTICS: LENGTH: 88 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .88 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:425 Met Phe Lys Lys Ile Ile Phe Leu Cys Val Phe Leu Ile Gly Gly Phe 1 5 10 Val Ile Pro Pro Leu Glu Ala Met Pro Ile Leu Arg Asn Lys Thr Pro 20 25 Lys Lys Asn Tyr Gin Giu Ala His Glu Lys Leu Tyr Arg Ser Ile Ile 35 40 Asn Arg Gin Unk Unk Thr-Arg Lys Lys Ser Gly Trp Tyr Phe Leu Gly 55 Gly Val Gly Ala Val Glu Ala Ile Lys Asp Tyr Gin Gly Lys Giu Met 70 75 Lys Asp Trp Met Pro Arg Se Ile INFORMATION FOR SEQ ID NO:426: SEQUENCE CHARACTERISTICS: LENGTH: 128 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...128 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:426 Val His Phe Thr Cys Ile Phe Leu Thr Leu Leu Lys Trp Ile Leu Pro 1 5 10 Ala Lys Asn Lys Gin Ala Cys Lys Lys Ala Thr Asn Gin Ile His Ser 25 Arg Unk Ala Lys His Pro Ala Lys Tyr Pro Pro Ser Ser Ile Asn Pro 40 Ser Ile Gin Ala Gly Ile Gin Gly Val Met Gin Gly Phe Gly Ala Leu 55 Ser Ser Unk Leu Glu Unk Pro Unk Phe Val Unk Unk Ala Lys Cys Gly 70 75 Trp Ile Gly Gly Phe Glu His Tyr Leu Ser Pro Leu Tyr Gly Trp Gly 90 Lys Ile His Asp Gly Ala His Cys Asp Leu Met Gin Lys Asp Ala Asn 100 105 110 Gly Arg Gly Ile Gly Leu Glu Lys Gly Leu Pro Pro Phe Lys Gly Leu 115 120 125 INFORMATION FOR SEQ ID NO:427: SEQUENCE CHARACTERISTICS: LENGTH: 108 amino acids TYPE: amino acid TOPOLOGY: linear o (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...108 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:427 Met Gin Lys Phe Phe Ser Arg Phe Arg Arg Trp Ala Leu Pro Phe Tyr 1 5 10 Phe Val Ser Ala Leu Ala Ala Ile Asp Ile Asp Glu Val Thr Glu Ala 25 Gin Ala Asn Ser Ile Lys Leu Ser Asp Gin Leu Val Ser Leu Ser Asp 40 Lys Leu Leu Glu Lys Ala Val Asp Arg Gly Arg Asn Thr Asp His Leu 55 Lys Asp Leu Asn Asp Leu His Glu Lys Ile Lys His Leu Arg Leu Ile 70 75 Leu Glu Pro Lys Pro Lys Gly Lys Glu Asp Ser Pro Asn Leu Gly Gly 90 Asn Lys Asp Met Lys Thr Val Glu Ile Gly Ser Gly 355 100 105 INFORMATION FOR SEQ ID NO:428: SEQUENCE CHARACTERISTICS: LENGTH: 118 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...118 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:428 Val Ile Leu Ala Phe Ala Phe Gly Met Ser Leu Leu Gly Leu Ala Gly 1 5 10 Met Phe Ile Asp Ile Pro Phe Leu Ser Thr Gly Val His Ile Pro Arg 25 Lys Glu Asp Ile Leu Trp Ile Ser Leu Ile Gly Ile Ser Gly Thr Leu 40 Gly Gin Tyr Phe Leu Thr Tyr Ala Tyr Met Asn Ala Pro Ala Gly Ile 50 55 Ile Ala Pro Ile Glu Tyr Thr Arg Ile Val Trp Gly Leu Leu Phe Gly 65 70 75 Leu Tyr Leu Gly Asp Thr Phe Leu Asp Leu Lys Ser Ser Leu Gly Val 85 90 Ala Leu Ile Leu Cys Ser Gly Leu Leu Ile Ala Leu Pro Ala Leu Leu S* 100 105 110 Lys Glu Leu Lys Lys Ile 115 INFORMATION FOR SEQ ID NO:429: SEQUENCE CHARACTERISTICS: LENGTH: 54 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...54 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:429 Met Ile Tyr Leu Gly Lys Lys Asn Phe Asn Ala Leu Leu Lys Gly Ala 1 5 10 Tyr Leu Met Asp Glu His Phe Arg Asn Ala Pro Phe Glu Ser Asn Leu 25 356 Pro Val Leu Met Gly Leu Ile Trp Arg Vai Val Tyr Leu Thr Phe Phe 40 Pro Ile Gin Lys Ala Thr INFORMATION FOR SEQ ID NO:430: SEQUENCE CHARACTERISTICS: LENGTH: 288 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Heiicobacter pyiori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .288 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:430 Met Ala Ala Lys Ser Lys Ala Unk Thr Leu Lys Vai Phe Ser Lys Phe 1 5 10 Phe Ser Asn Phe Lys Ile Thr Lys Leu Lys Asp Asn His Giu Giu Ala 25 His Lys Leu Phe Gly Giu Asn Ser Arg Lys Ala His Asp Thr Giu Ile 35 40 IeTrSer Thr Leu Gin Val Val Pro Arg Tyr Ser Ile Giu Thr Val 55 Gly Phe Ser Leu Leu Ile Leu Ala Val Ala Tyr Ile Leu Phe Lys Tyr 70 75 *Gly Glu Ala Arg Met Val Leu Pro Thr Ile Ser Met Tyr Ala Leu Ala 90 Leu Tyr Arg Ile Leu Pro Ser Val Thr Gly Vi Ile Ser Tyr Tyr Asn 100 105 110 Giu Ile Ala Tyr Asn Gin Leu Ala Thr Asn Val Val Phe Lys Ser Leu 115 120 125 Ser Lys Thr Ile Val Glu Giu Asp Leu Val Pro Leu Asp Phe Asn Giu 130 135 140 *Lys Ile Thr Leu Gin Asn Ile Ser Phe Ala Tyr Lys Ser Lys His Pro 145 150 155 160 Val Leu Lys Asn Phe Asn Leu Thr Ile Gin Lys Gly Gin Lys Ile Ala 165 170 175 eLeu Ile Gly His Ser Giy Cys Gly Lys Ser Thr Leu Ala Asp Ile Ile 180 185 190 Met Gly Leu Thr Tyr Pro Lys Ser Gly Glu Ile Phe Ile Asp Asn Thr 195 200 205 Leu Leu Thr Ser Giu Asn Arg Arg Ser Trp Arg Lys Lys Ile Gly Tyr 210 215 220 Ile Pro Gin Asn Ile Tyr Leu Phe Asp Gly Thr Val Gly Asp Asn Ile 225 230 235 240 Ala Phe Gly Ser Ala Ile Asp Giu Lys Arg Leu Ile Lys Val Cys Lys 245 250 255 Met Ala His Ile Tyr Asp Phe Leu Cys Giu His Glu Gly Leu Lys Thr 260 265 270 Gin Val Gly Giu Gly Ala Leu Ser Leu Ala Ala Val Lys Asn Ser Ala 275 280 285 INFORMATION FOR SEQ ID NO:43i: SEQUENCE CHARACTERISTICS: LENGTH: 303 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .303 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:431 a a a a Met Gin Ser Thr Ile Ala Thr Gin Thr Lys 145 Ile Giy Vai Ser Sen 225 Asp Ile Ang Ala Ala Sen Sen Val Ala Met Gin Sen Thr 130 Giu Gly Ala Asp Ala 210 Asn Val His Leu Tyr 290 Ala Gly Ala Asn Asp Ala Asp 115 Thr Phe Ser Leu Gly 195 Gly Arg Ala Leu Val 275 Thr Leu Thr Leu Arg Asp Ser Thr Asn Glu Gin Ala Gin 100 Ile Val Tyr Asn Gin Val Thn Thr 165 Ile Thn 180 Val Asn Thr Gly Thn Gly Val Gin 245 Gly Asn 260 Thr Ala Asp Gin Gin Ile Leu Asp 70 Leu Asp Arg Gly G ly 150 Ser Ala Asp Ile Val 230 Sen Ile Ile Lys Asn Ala Asn Lys 40 Ang Ser Gly Met Lys Ile Gly Gin Leu Ile 120 Gin Ala 135 Ala Tyr Asp Lys Ser Gly Val Thr 200 Gly Val 215 Lys Ala Gly Ser Ala Asp Asn. Ala 280 Gly Arg 295 Leu 25 Ala Gin Gly Leu Thr 105 Gin Leu Ser Ile Asp 185 Leu Leu Leu Ile 265 Val Leu 10 Lys Ala Ala Ile Asp Thr Gly Leu Asn Gly 170 Ile Giu Ala Ala Ser 250 Lys Thr Thr Asp Ser Ile Thr Glu Leu Ser Gin 155.
Gin Ser Ser Giu Sen 235 Asn Unk Ser Leu Aia Leu Val1 Lys Arg Asn 125 Gin Ile Arg Thr Lys 205 Ile Ile Thr Asp Thr 285 is Glu Arg Ser Giy Gly Gin Ala Asp Val Lys Lys Ala 110 Ile Gly Phe Thr Lys Ala Ile Ala 175 Phe Lys 190 Val Sen Asn Lys Thr Thr Leu Asn 255 Ser Asp 270 Gly Val Phe Gin Val Asn Thr Asn Ile Asn Ala Met Asn Ala His Val Asn Leu Arg Ser Ile Gly INFORMATION FOR SEQ ID NO:431: Mi SEQUENCE CHARACTERISTICS: LENGTH: 303 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I. .303 (xi) SEQUENCE DESCRIPTION: SEQ ID NO;431 4* 4* 4* *4 9 9. 9* S. 9 .5
S
.9 S S 9 Met Gin Ser Thr Ile Ala Thr Gin Thr
LYS
145 Ile Gly Val Ser Ser 225 Asp Ile Arg Ala Ser Ser Vali Ala Met Gin Ser Thr 130 Giu dly Ala Asp Ala 21.0 Asn Val His Leu Tyr 290 Ala Gly Ala Asn Asp Ala Asp 115 Thr Phe Ser Leu Gly 195 Gly Arg Ala Leu Val 275 Thr Leu Leu Asp Thr Glu Ala 100 Ile Tyr Gin Thr Ile 180 Val1 Thr Thr Val Gly 260 Thr Asp Asn As n Arg Gly Lys Gly Leu Gin 135 Ala Asp Ser Val Gly 215 Lys Gly Ala Asn dly 295 Glu Ser Gly Ala Val1 Lys 110 Ile Phe Lys Ile Phe 190 Val Asn Thr Leu Ser 270 Gly Ile Arg Gly Gin Asp Lys Ala Gly Thr Ala Ala 175 Lys Ser Lys Thr Asn 255 Asp Val Gly Leu Met Ala Lys Ala le Asn Asn Ser 160 Thr Gin Ser Asn Ser 240 Gly Gly Unk Ala Phe Gin Val Asn Thr Asn Ile Asn Ala Met Asn Ala His Val INFORMATION FOR SEQ ID NO:432: SEQUENCE CHARACTERISTICS: LENGTH: 192 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...192 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:432 Met Leu Asp Ile Trp Ile Asp Met Ile Ile Cys Ile Phe Tyr Leu Leu 1 5 10 Phe Phe Thr Thr Pro Tyr Ile Val Gly Asp Ile Leu Gin Leu Lys Phe 25 Ile Arg Gin Lys Leu Cys Glu Lys Pro Val Leu Leu Pro Gin Lys Asp 40 Tyr Glu Glu Ala Gly Asn Tyr Ala Ile Arg Lys Met Gin Leu Ser Ile 55 Ile Ser Gin Ile Leu Asp Gly Val Ile Phe Ala Gly Trp Val Phe Phe 70 75 Gly Leu Thr His Leu Glu Asp Leu Thr His Tyr Leu Asn Leu Pro Glu 90 Thr Leu Gly Tyr Leu Val Phe Ala Leu Leu Phe Leu Ala Ile Gin Ser 100 105 110 Val Leu Ala Leu Pro Ile Ser Tyr Tyr Thr Thr Met His Leu Asp Lys 115 120 125 Glu Phe Gly Phe Ser Lys Val Ser Leu Ser Leu Phe Phe Lys Asp Phe 130 135 140 Phe Lys Gly Leu Leu Leu Thr Leu Gly Val Gly Leu Leu Leu Ile Tyr 145 150 155 160 Thr Leu Ile Met Ile Ile Glu His Val Glu His Trp Glu Ile Ser Ser 165 170 175 Phe Phe Val Val Phe Val Phe Met Ile Leu Ala Asn Leu Phe Leu Pro 180 185 190 INFORMATION FOR SEQ ID NO:433: SEQUENCE CHARACTERISTICS: LENGTH: 168 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES "*99 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...168 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:433 Met Leu Lys Lys Ile Phe Leu Thr Asn Ser Leu Gly Ile Leu Cys Ser 1 5 10 Arg Ile Phe Gly Phe Leu Arg Asp Leu Met Met Ala Asn Ile Leu Gly 25 Ala Gly Val Tyr Ser Asp Ile Phe Phe Val Ala Phe Lys Leu Pro Asn 40 Leu Phe Arg Arg Ile Phe Ala Glu Gly Ser Phe Ser Gin Ser Phe Leu 55 Pro Ser Phe Ile Arg Ser Ser Ile Lys Gly Gly Phe Ala Ser Leu Val 70 75 360 Gly Leu Ile Phe Cys Gly Val Leu Phe Met Trp Cys Leu Leu Val Ala 90 Leu Asn Pro Leu Trp Leu Thr Lys Leu Leu Ala Tyr Gly Phe Asp Glu 100 105 110 Giu Thr Leu Lys Leu Cys Thr Pro Ile Val Ala Ile Asn Phe Trp Tyr 115 120 125 Leu Leu Leu Val Phe Ile Thr Thr Phe Leu Gly Ala Leu Leu Gin Tyr 130 135 140 Lys His Ser Phe Phe Aia Ala Leu Met Arg Lys Leu Thr Gin Phe Met 145 150 155 160 His Asp Phe Ser Pro Phe Asp Phe 165 INFORMATION FOR SEQ ID NO:434: SEQUENCE CHARACTERISTICS: LENGTH: 153 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyl'or (ix) FEATURE: too* NAME/KEY: misc-feature LOCATION .153 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:434 Met Asn Leu Glu Val Ala Leu Lys Ala Phe Giu Thr Leu Leu Pro Cys 1 5 10 Asn Lys Gin Giu Val Leu Lys Asn Leu Lys Pro Leu Asp Leu Ile Gly *20 25 Arg Cys Glu Leu Leu Ser Pro Asn Ile Leu Ile Asp Val Gly His Asn P3oHi 40 PoHsSer Ala Lys Ala Leu Lys Giu Glu Ile Lys Arg Ile Phe Asn so. 55 Ala Pro Ile Val Leu Ile Tyr Asn Cys Tyr Gin Asp Lys Asp Ala Phe 70 75 Leu Val Leu Giu Ile Leu Lys Ser Val Val Lys Lys Val Leu Ile Leu 90 Glu Leu His Asn Glu Arg Ile Ile Gin Leu Giu Lys Leu Lys Gly Ile 10105 110 Leu Glu Thr Leu Gly Leu Giu His Ala Leu Phe Giu Giu Leu Lys Giu 115 120 125 Asn Giu Asn Tyr Leu Val Tyr Giy Ser Phe Leu Val Ala Asn Aia Phe 130 1j35 140 Tyr Glu Arg Tyr Pro Lys Lys Arg Asp 145 150 INFORMATION FOR SEQ ID NO:435: SEQUENCE CHARACTERISTICS: LENGTH: 161 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylon- (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 161 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:435 Met Leu G 1u Asp Val Gin Ile Asn Giu 145
LYS
Phe Tyr Met Ser Asn Val Lys Ser Phe 130 Ala Phe Leu Ile Ile Phe Thr Ile Gln 115 Gly Giu Lys Thr Val Gly Unk Asn Thr Ile Val Pro Pro Ile Phe Asp 100 Leu Giu Giu Ser Ile Gin Tyr Gin Cys Gly Ser Giu Gin Gly Val Sen 70 Ser Ile Gin Lys Gin Lys Leu Lys 135 Thr Asp 150 Leu Leu Giy Gly Gly Gly 25 Thr Phe Gin Ala Ser Cys Leu Ala Leu Phe Phe Leu Met Ser Ala Ser Ser As n Val1 Ala Ala 110 Unk Asn As n Val1 Ala Ala Ser Thr Lys Leu Ile Asp 160
S
S
S S SO S
S.
0555
S
S. 55
S
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S S5 555.
S 54 *5 S
S
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SS
0
S
INFORMATION FOR SEQ ID NO:435: SEQUENCE CHARACTERISTICS: LENGTH: 161 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .161 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:435 Phe Phe Lys Thr Tyr Gin Lys Leu Leu Gly 5 10 Tyr Leu Val Gly Cys Gly Asn Gly Gly Gly 25 Met Ile Unk Asn Sen Glu Gly Thr Phe Gin 40 Ser Ile Thr Ile Gin Gly Vai Lys Leu Asn so 55 Asn Phe Val Pro Vai Sen Giu Thr Phe Gin 1 70 Met 1 Leu Glu Asp Val Ala Ser Cys Leu is Gly Giu Sen Pro Ile Asp Ser Lys Arg Gly Asn Cys Met Gly Val Leu Val Thr Pro Ile Lys Ile Phe Asp 100 Ser Gin Leu Glu 115 Phe Gly Glu Ser 130 Ala Glu Ile Gin Ser Ile Gin Asp Phe 90 Gin Lys Lys Gly Leu 105 Gin Lys Gly Val Met 120 Leu Lys Gly Ile Ser 135 Thr Asp Lys Gly Ala 150 362 Lys Asp Met Ala Ser Thr Ala Asn Ile Ala Asn Lys 110 Met Lys Pro Unk Thr Leu 125 Gin Gly Cys Asn Ile lle 140 Trp Thr Phe Asn Phe Asp 155 160 o INFORMATION FOR SEQ ID NO:436: SEQUENCE CHARACTERISTICS: LENGTH: 59 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...59 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:436 Met Ala Ile Gly Phe Pro Leu Val Phe Gly Ile Leu Leu Thr Leu Phe 1 5 10 Ser Arg Ser Tyr Trp Arg Glu Phe Gly Gly Val Ser Gly Val Leu Trp 25 Arg Ala Ser Gly Phe Ser Gly Ala Lys Val Glu Arg Asn Leu Glu Arg 40 Asp Pro His Ala Phe Phe Thr His Cys Asp Phe 50 INFORMATION FOR SEQ ID NO:437: SEQUENCE CHARACTERISTICS: LENGTH: 222 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE- protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...222 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:437 Met Lys Lys Lys Ala Lys Val Phe Trp Cys Cys Phe Lys Met Ile Arg 1 5 10 Trp Leu Tyr Leu Ala Val Phe Phe Leu Leu Ser Val Ser Asp Ala Lys 25 Glu Ile Ala Met Gin Arg Phe Asp Lys Gin Asn His Lys Ile Phe Glu 40 lie Leu Ala Asp Lys Val Ser Ala Lys Asp Asn Val Ile Thr Ala Ser 55 Gly Asn Ala Ile Leu Leu Asn Tyr Asp Val Tyr Ile Leu Ala Asp Lys 70 75 Val Arg Tyr Asp Thr Lys Thr Lys Glu Ala Leu Leu Glu Gly Asn Ile 90 Lys Val Tyr Arg Gly Glu Gly Leu. Leu Val Lys Thr Asp Tyr Val Lys 100 105 110 Leu Ser Leu Asn Glu Lys Tyr Glu Ile Ile Phe Pro Phe Tyr Val Gin 115 120 125 Asp Ser Val Ser Gly Ile Trp Val Ser Ala Asp Ile Ala Ser Gly Lys 130 135 140 Asp Gin Lys Tyr Lys Ile Lys Asn Met Ser Ala Ser Gly Cys Ser Ile 145 150 155 160 Asp Asn Pro Ile Trp His Val Asn Ala Thr Ser Gly Ser Phe Asn Met 165 170 175 Gin Lys Ser His Leu Ser Met Trp Asn Pro Lys Ile Tyr Val Gly Asp 180 185 190 Ile Pro Val Leu Tyr Leu Pro Tyr Ile Phe Met Ser Thr Ser Asn Lys 195 200 205 S* Arg Thr Thr Gly Phe Leu Tyr Pro Glu Phe Gly Thr Ser Thr 210 215 220 INFORMATION FOR SEQ ID NO:438: 0. SEQUENCE CHARACTERISTICS: LENGTH: 53 amino acids TYPE: amino acid TOPOLOGY: linear .0 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...53 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:438 Met Leu Asp Phe Asp Leu Val Leu Phe Gly Ala Thr Gly Asp Leu Ala 1 5 10 Met Arg Lys Leu Phe Val Ser Leu Tyr Glu Ile Tyr Ile Ser Phe Met 25 Val Leu Lys Thr Ile Leu Gly Leu Ser His Arg Gly Val Arg Ser Tyr 40 Pro Met Lys Ser Phe INFORMATION FOR SEQ ID NO:439: SEQUENCE CHARACTERISTICS: LENGTH: 109 amino acids TYPE: amino acid TOPOLOGY: linear 364 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...109 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:439 Met Gin Asp Leu Pro Pro Cys Pro Lys Arg Asn Asp Ala Tyr Thr Tyr 1 5 10 His Asp Gly Thr Gin Phe Val Cys Ser Ser Cys Leu Tyr Glu Trp Asn 25 Gly Asn Glu Ile Ser Asn Glu Glu Leu Ile Val Lys Asp Cys His Asn 40 Asn Leu Leu Gin Asn Gly Asp Ser Val Ile Leu Ile Lys Asp Leu Lys 55 Val Lys Gly Ser Ser Leu Val Leu Lys Lys Gly Thr Lys Ile Lys Asn 70 75 S Ile Lys Leu Val Asn Ser Asp His Asn Val Asp Cys Lys Val Glu Gly 85 90 Gin Ser Leu Ser Leu Lys Ser Glu Phe Leu Lys Lys Ala 100 105 INFORMATION FOR SEQ ID NO:440: S(i) SEQUENCE CHARACTERISTICS: LENGTH: 73 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...73 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:440 Val Asp Gly Ala Ile Ile Thr Gly Asn Tyr Ala Leu Gin Ala Lys Leu 1 5 10 Thr Gly Ala Leu Phe Ser Glu Asp Lys Asp Ser Pro Tyr Ala Asn Leu 25 Val Ala Ser Arg Glu Asp Asn Ala Gin Asp Glu Ala Ile Lys Ala Leu 40 Ile Glu Ala Leu Gin Ser Glu Lys Thr Arg Lys Phe Ile Leu Asp Thr 55 Tyr Lys Gly Ala Ile Ile Pro Ala Phe INFORMATION FOR SEQ ID NO:441: SEQUENCE CHARACTERISTICS: LENGTH: 237 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .237 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:44i
S
S.
S. S
S
S S S.
S
S S
S
Val1 Phe Phe Val Ile 65 Leu Phe Leu Ala Pro 145 Gly Asp Tyr Pro Gin 225 Phe Ile Trp Met Phe Asn Ile Ala Thr 130 Leu Aia Leu Val Leu 210 Cys Gly Asn Trp Asn Gly Asn 115 Thr Tyr Phe Lys Cys 195 Tyr His Trp His Arg As n Ala Ala 100 Ala Met Sen Val1 Axg 180 Sen Ala Ala Glu Lys Ile Phe Asp 85 Met Met Vai Ala Ala 165 Ile Gly Cys Cys Gly Lys Thr dly 70 Tyr G ly Giu Thr Val 150 Leu Val Arg Val Asp 230 Val1 Ser Asp Thr Ser Lys Gly Ala 135 Phe Phe Giu Ala Leu 215 Giy Gly Ala Leu Leu Met Ser Pro 120 Gly Giu Gly Tyr Tnp 200 Gin Arg Leu 25 Asn Gly Gin Leu Ala 105 Thn Val1 Val1 Ala Ser 185 Gly Ile Gin Cys Asn Met Tyr Phe 90 Gin Pro Tyr Gly Ser 170 Thr Leu Pro Ser Ser Ala Leu Lys Tyr Phe Val1 Leu Tyr 155 Met Leu Cys Pro Gly 235 Leu Glu Ile Phe Val1 .His 110 Leu Arg Ala Val1 Leu 190 Ala Arg is Ile Ala I le Ser Phe Thr Ile Ala Cys Asn 175 Gly Phe Leu Thr Met Leu Val Leu Val Leu Ser Asp Asn Phe Leu Gly Leu INFORMATION FOR SEQ ID NO:442: SEQUENCE CHARACTERISTICS: LENGTH: 91 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacten pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1...91 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:442 Val Cys Leu Gly Leu Ala Asp Val Met Val Val Leu Ser Leu His Leu 1 5 10 Asn Leu Asn Pro Thr Asn Pro Lys Trp Leu Asn Arg Asp Arg Leu Val 25 Phe Ser Gly Gly His Ala Ser Ala Leu Val Tyr Ser Leu Leu His Leu 40 Trp Gly Phe Asp Leu Ser Leu Asp Asp Leu Lys Arg Phe Arg Gin Leu 55 His Ser Lys Thr Pro Gly His Pro Glu Leu His His Thr Glu Gly Ile 70 75 Glu Ile Thr Thr Unk Phe Arg Ala Arg Phe Cys INFORMATION FOR SEQ ID NO:442: SEQUENCE CHARACTERISTICS: LENGTH: 91 amino acids TYPE: amino acid TOPOLOGY: linear o*o* (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori S(ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...91 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:442 Val Cys Leu Gly Leu Ala Asp Val Met Val Va'l Leu Ser Leu His Leu 1 5 10 Asn Leu Asn Pro Thr Asn Pro Lys Trp Leu Asn Arg Asp Arg Leu Val 20 25 Phe Ser Gly Gly His Ala Ser Ala Leu Val Tyr Ser Leu Leu His Leu 40 Trp Gly Phe Asp Leu Ser Leu Asp Asp Leu Lys Arg Phe Arg Gin Leu 50 55 His Ser Lys Thr Pro Gly His Pro Glu Leu His His Thr Glu Gly Ile 70 75 Glu Ile Thr Thr Unk Phe Arg Ala Arg Phe Cys INFORMATION FOR SEQ ID NO:443: SEQUENCE CHARACTERISTICS: LENGTH: 97 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...97 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:443 Met Met Ile Thr Lys Gin Ser Tyr Gin Arg Phe Ala Leu Met Arg Val 1 5 10 Phe Val Phe Ser Leu Ser Ala Phe Ile Phe Asn Thr Thr Glu Phe Val 25 Pro Val Ala Leu Leu Ser Asp Ile Ala Lys Ser Phe Glu Met Glu Ser 40 Ala Thr Val Gly Leu Met Ile Thr Ala Tyr Ala Trp Val Val Ser Leu 55 Gly Ser Leu Pro Leu Met Leu Leu Ser Ala Lys Ile Glu Arg Lys Arg 70 75 Leu Leu Leu Phe Leu Phe Ala Leu Phe Ile Phe Ser His Ile Leu Ser 90 Arg INFORMATION FOR SEQ ID NO:444: SEQUENCE CHARACTERISTICS: 0. LENGTH: 280 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...280 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:444 Met Lys Leu Arg Ala Ser Val Leu Ile Gly Val Ala Ile Leu Cys Leu 1 5 10 o Ile Leu Ser Ala Cys Ser Asn Tyr Ala Lys Lys Val Val Lys Gin Lys 25 Asn His Val Tyr Thr Pro Val Tyr Asn Glu Leu Ile Glu Lys Tyr Ser 40 Glu Ile Pro Leu Asn Asp Lys Leu Lys Asp Thr Pro Phe Met Val Gin 55 Val Lys Leu Pro Asn Tyr Lys Asp Tyr Leu Leu Asp Asn Lys Gin Val 70 75 Val Leu Thr Phe Lys Leu Val His His Ser Lys Lys Ile Thr Leu Ile 90 Gly Asp Ala Asn Lys Ile Leu Gin Tyr Lys Asn Tyr Phe Gin Ala Asn 100 105 110 Gly Ala Arg Ser Asp Ile Asp Phe Tyr Leu Gin Pro Thr Leu Asn Gin 115 120 125 Lys Gly Val Val Met Ile Ala Ser Asn Tyr Asn Asp Asn Pro Asn Asn 130 135 140 Lys Glu Lys Pro Gin Thr Phe Asp Val Leu Gin Gly Ser Gin Pro Met 145 150 155 160 Leu Gly Ala Asn Thr Lys Asn Leu His Gly Tyr Asp Val Ser Gly Ala 165 170 175 Asn Glu Giu Ser 225 Ile Arg Ile Lys Ile 195 Thr Arg Lys Lys Ser 275 Asn Giu Tyr Lys 200 Asn Asn 215 Gin Met Leu Asn Giu Arg Gly Lys 280 Vai Ala 185 Thr Leu Gin Arg Arg Gin Met Gin 250 Giu Asn 265 368 Arg Giu Leu Gin Giu Ile 220 Asn Vai 235 Ala Lys Giu Tyr a.
a. a. a.
a a INFORMATION FOR SEQ ID NO:445: SEQUENCE CHARACTERISTICS: LENGTH: 187 amino acids TYPE: amino acid TOPOLOGY: iinear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .187 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:445 1Met Thr Thr Pro Met Ile Ile Ile Sen Leu Giu Met Gly Leu Sen Leu a a.
a a Val1 Ser Lys Ile 65 Asp Thn Gly Ser Asp 145 Tyr G ly Pro Trp Phe Ala Asp Val1 Leu 130 Phe Asn Unk Met Asn 35 Ala Ang Tyn Ang Trp 115 Gly Gly Ala Unk Arg 20 Gly Ala Phe Leu G ly 100 Leu Val Phe Unk Phe 180 Gin Leu Tyr Lys Pro Phe Gly Leu Leu Thr 165 Glu Cys Gly His Thn 70 Leu Ang dly Lys Thr 150 Thr Unk Leu Gly His 55 Gin Asn Asn Asp Ala 135 Phe Thr Ala Val Asn 40 Leu Gly Ser Gly Gly 120 Ala Unk Ala Thr Cys 25 Val Gin Gly Thr Ser 105 Ile Lys Thr Asn Trp 185 Gin Arg Lys Tyr Phe I le Phe Met Pro Phe 170 Arg Ala Asn Tyr Ile 75 Tyr Thr Thr Arg Thr Lys Ala Leu Thr Leu Phe Met Pro Unk Leu 140 Ang Asp Ala Lys Leu Arg G ly Lys Sen 125 Ala Gly Tyr Ang Val1 Ile Tyr Gly Asp 110 Thr Trp Ser Unk Se Ile Tyr Giy Asp Leu Asn Thn Val Thr Giu Phe Giu Leu Phe Phe Phe Phe 160 Val Val 175 INFORMATION FOR SEQ ID NO:44S:
SEQUENCE-CHARACTERISTICS:
LENGTH: 187 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...187 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:445 Met Thr Thr Pro Met Ile Ile Ile Ser Leu Glu Met Gly Leu Ser Leu 1 5 10 Val Pro Met Arg Gin Cys Leu Val Cys Gin Ala Leu Ala Arg Ser Ile 25 Ser Trp Asn Gly Leu Gly Gly Asn Val Arg Asn Thr Lys Val Tyr Gly 40 Lys Phe Ala Ala Tyr His His Leu Gin Lys Tyr Leu Leu Ile Asp Leu 55 Ile Ala Arg Phe Lys Thr Gin Gly Gly Tyr Ile Phe Arg Tyr Asn Thr 65 70 75 Asp Asp Tyr Leu Pro Leu Asn Ser Thr Phe Tyr Met Gly Gly Val Thr 85 90 Thr Val Arg Gly Phe Arg Asn Gly Ser Ile Thr Pro Lys Asp Glu Phe 100 105 110 Gly Leu Trp Leu Gly Gly Asp Gly Ile Phe Thr Unk Ser Thr Glu Leu S115 120 125 Ser Tyr Gly Val Leu Lys Ala Ala Lys Met Arg Leu Ala Trp Phe Phe 130 135 140 Asp Phe Gly Phe Leu Thr Phe Unk Thr Pro Thr Arg Gly Ser Phe Phe 145 150 155 160 Tyr Asn Ala Unk Thr Thr Thr Ala Asn Phe Lys Asp Tyr Unk Val Val 165 170 175 Gly Unk Unk Phe Glu Unk Ala Thr Trp Arg Ala 180 185 INFORMATION FOR SEQ ID NO:446: SEQUENCE CHARACTERISTICS: LENGTH: 58 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...58 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:446 Met Trp Leu Asp His Ile Ala Lys Glu Ile Arg Ser Leu Val Glu Asn 1 5 10
I
Asp Val Met Ile Glu Val Gly Ile Val Ile Gly Gly Gly Asn Ile Ile Arg Gly 25 Ser Ala Ala Leu Gly Gly Ile Ile Arg Arg Thr Ser Gly Asp Tyr 40 Gly Met Leu Ala Thr Val Ile Lys Arg 9 9 9 ,9 99 9 994 9 ft f INFORMATION FOR SEQ ID NO:447: SEQUENCE CHARACTERISTICS: LENGTH: 85 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...85 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:447 Val His Asn Phe His Trp Asn Val Lys Gly Thr Asp Phe Phe Asn Val 1 5 10 His Lys Ala Thr Glu Glu Ile Tyr Glu Gly Phe Ala Asp Met Phe Asp 25 Asp Leu Ala Glu Arg Ile Val Gin Leu Gly His His Pro Leu Val Thr 35 40 Leu Ser Glu Ala Ile Lys Leu Thr Arg Val Lys Glu Glu Thr Lys Thr 50 55 Ser Phe His Ser Lys Asp Ile Phe Lys Glu Ile Leu Glu Asp Tyr Lys 70 75 His Leu Glu Lys Glu INFORMATION FOR SEQ ID NO:448: SEQUENCE CHARACTERISTICS: LENGTH: 90 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...90 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:448 Met Asn Lys Thr Ile Lys Ala Ala Ala Leu Ala Tyr Asn Met Gly Gin 1 5 10 Asp His Ala Pro Lys Val Ile Ala Ser Gly Val Gly Glu Val Ala Lys 25 Arg Ile Ile Gin Lys Ala Lys Glu Tyr Asp Ile Ala Leu Phe Ser Asn 40 Pro Met Leu Val Asp Ser Leu Leu Lys Val Glu Leu Asp Cys Ala Ile 55 Pro Glu Glu Leu Tyr Glu Ser Val Val Gin Val Phe Leu Trp Leu Asn 70 75 Ser Val Glu Asn Asn Ala Gin Met Ser Lys INFORMATION FOR SEQ ID NO:449: SEQUENCE CHARACTERISTICS: LENGTH: 104 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...104 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:449 Met Gin Ala Leu Lys Ser Leu Leu Glu Val Ile Thr Lys Leu Gin Asn S1 5 10 Leu Gly Gly Tyr Leu Met His Ile Ala Ile Phe Ile Ile Phe Ile Trp 25 Ile Gly Gly Leu Lys Phe Val Pro Tyr Glu Ala Glu Gly Ile Ala Pro 35 40 Phe Val Unk Asn Ser Pro Phe Phe Ser Phe Met Tyr Lys Phe Glu Lys 55 Pro Ala Tyr Lys Gin His Lys Met Ser Glu Ser Gin Ser Met Gin Glu 65 70 75 Glu Met Gin Asp Asn Pro Lys Ile Val Glu Asn Lys Unk Trp His Lys 85 90 Glu Asn Arg Thr Ser Phe Ser Gly 100 INFORMATION FOR SEQ ID NO:449: SEQUENCE CHARACTERISTICS: LENGTH: 104 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...104 372 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:449 Met Gin Ala Leu Lys Ser Leu Leu Glu Val Ile Thr Lys Leu Gin Asn 1 5 10 Leu Gly Gly Tyr Leu Met His Ile Ala Ile Phe Ile Ile Phe Ile Trp 25 Ile Gly Gly Leu Lys Phe Val Pro Tyr Glu Ala Glu Gly Ile Ala Pro 40 Phe Val Unk Asn Ser Pro Phe Phe Ser Phe Met Tyr Lys Phe Glu Lys 55 Pro Ala Tyr Lys Gin His Lys Met Ser Glu Ser Gin Ser Met Gin Glu 70 75 Glu Met Gin Asp Asn Pro Lys Ile Val Glu Asn Lys Unk Trp His Lys 90 Glu Asn Arg Thr Ser Phe Ser Gly 100 INFORMATION FOR SEQ ID NO:450: SEQUENCE CHARACTERISTICS: LENGTH: 172 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...172 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:450 Met Gly Lys Ile Ser Ala His Leu Ala His Glu Ile Arg Asn Pro Val 1 5 10 Gly Ser Ile Ser Leu Leu Ala Ser Val Leu Leu Lys His Ala Asn Glu 20 25 Lys Thr Lys Pro Ile Val Val Glu Leu Gin Lys Ala Leu Trp Arg Val 40 Glu Arg Ile Ile Lys Ala Thr Leu Leu Phe Ser Lys Gly Ile Gin Ala 55 Asn Arg Thr Lys Gin Ser Leu Lys Thr Leu Glu Ser Asp Leu Lys Glu 70 75 Ala Leu Asn Cys Tyr Thr Tyr Ser Lys Asp Ile Asp Phe Leu Phe Asn 90 Phe Ser Asp Glu Glu Gly Phe Phe Asp Phe Asp Leu Met Gly Ile Val 100 105 110 Leu Gin Asn Phe Leu Tyr Asn Ala Ile Asp Ala Ile Glu Ala Leu Glu 115 120 125 Glu Ser Glu Gin Gly Gin Val Lys Ile Glu Ala Phe Ile Gin Asn Glu 130 135 140 Phe Ile Val Phe Thr Ile Ile Asp Asn Gly Lys Glu Val Glu Asn Lys 145 150 155 160 Ser Ala Leu Phe Glu Pro Phe Glu Thr Thr Lys Leu 165 170 INFORMATION FOR SEQ ID NO:451: SEQUENCE CHARACTERISTICS: LENGTH: 212 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...212 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:451 Val Ser Glu Phe His Gin Val Tyr Asp Pro Leu Gly Asn Ile Trp Leu 1 5 10 Ser Ala Leu Val Ala Leu Leu Pro Ile Leu Leu Phe Phe Leu Ser Leu 25 Met Val Phe Lys Leu Lys Gly Tyr Thr Ala Ala Phe Leu Ser Val Ala 40 Leu Ser Ala Ile Iie Ala Val Leu Val Tyr Lys Met Pro Val Ser Met 55 Val Gly Ser Ser Phe Leu Tyr Gly Phe Leu Tyr Gly Leu Trp Leu Phe 70 75 Ala Trp Ile Ile Ile Ala Ala Ile Phe Leu Tyr Lys Leu Ser Val Lys 85 90 Ser Gly Tyr Phe Glu Ile Leu Lys Glu Ser Val Gin Ser Ile Thr Leu 100 105 110 Asp His Arg Ile Leu Val Ile Leu Ile Gly Phe Cys Phe Gly Ser Phe 115 120 125 Leu Glu Gly Ala Ile Gly Phe Gly Gly Pro Ile Ala Ile Thr Ala Ala 130 135 140 Ile Leu Val Gly Leu Gly Leu Ser Pro Leu Tyr Ser Ala Gly Leu Cys 145 150 155 160 Leu Ile Ala Asn Thr Ala Pro Val Ala Phe Gly Ala Val Gly Ile Pro 165 170 175 Ile Se r Ala Met Ala Ser Ala Val Gly Val Pro Ala Ile Leu Ile Ser 180 185 190 Ala Met Thr Gly Lys Ile Leu Phe Phe Val Ser Leu Leu Val Pro Phe 195 200 205 Phe Ile Val Phe 210 INFORMATION FOR SEQ ID NO:452: SEQUENCE CHARACTERISTICS: LENGTH: 182 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...182
I
374 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:452 Met Gu Ile Lys Met Ala Lys Asp Tyr Gly Phe Cys Phe Gly Val Lys 1 5 10 Arg Ala Ile Gin Ile Ala Glu Lys Asn Gin Asn Ser Leu Ile Phe Gly 25 Ser Leu Ile His Asn Ala Lys Glu Ile Asn Arg Leu Giu Lys Asn Phe 40 Asn Val Lys Ile Giu Giu Asp Pro Lys Lys Ile Pro Lys Asn Lys Ser 55 Vai Ile Ile Arg Thr His Gly Ile Pro Lys Gin Asp Leu Gbu Tyr Leu 70 75 Lys Asn Lys Gly Val Lys Ile Thr Asp Ala Thr Cys Pro Tyr Vai Ile 90 Lys Pro Gin Gin Ile Val Glu Ser Met Ser Lys Glu Gly Tyr Gin Ile 100 105 110 Val Leu Phe Gly Asp Ile Asn His Pro Glu Val Lys Gly Vai Ile Ser 115 120 125 Tyr Ala Thr Asn Gin Ala Leu Val Gly Asn Ser Leu Glu Giu Leu Gin 130 135 140 Gbu Lys Lys Leu Gin Arg Lys Val Ala Leu Val Ser Gin Thr Thr Gin 145 150 155 160 Ala Asn Pro Lys Thr Leu Ala Asn Arg Phe Leu Phe S'ly Gly Unk Cys 165 170 175 Thr Glu Val Arg Ile Phe 9. 180 INFORMATION FOR SEQ ID NO:453: SEQUENCE CHARACTERISTICS: LENGTH: 224 amino acids TYPE: amino acid TOPOLOGY: linear.
(ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 224 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:453 Met Asp His Glu Phe Leu Ile Thn Met Arg Leu Ser Phe Ser Leu Ala 1 5 10 is Leu Ile Tbr Thr Le Ile Leu Leu Pro Ile Gly Ile Phe Leu Gly Tyr -25 Phe Leu Ser Leu Lys Ang Asn Leu Leu Thr Sen Leu Thn Glu Thr Leu 40 Val Tyr Met Pro Leu Val Leu Pro Pro Ser Val Leu Gly Phe Tyr Leu so 55 Leu Leu Ile Phe Ser Pro Ser Ser Phe Leu Gly Ala Phe Leo Gin Asp 70 75 Val Leo Asn Val Lys Leo Val Phe Ser Phe Gin Gly Leo Ile Leu Gly 90 Ser Val Ile Phe Ser Leo Pro Phe Met Val Ser Pro Ile Lys Sen Ala 100 105 110 Leu Ile Sen Leu Pro Thr Ser Leo Lys Gbu Ala Ser Tyr Ser Leo Gly 115 120 125 Lys Gly Glu Tyn Tyr Thr Leu Phe Phe Val Leo Leo Pro Asn Ile Lys 375 130 135 140 Pro Ser Val Leu Met Ala Ile Ile Thr Thr Phe Met His Thr Ile Gly 145 150 155 160 Glu Phe Gly Val Val Met Met Leu Gly Gly Asp Ile Leu Gly Glu Thr 165 170 175 Arg Val Ala Ser Ile Thr Ile Phe Asn Glu Ala Glu Ala Leu Asn Tyr 180 185 190 Ser Lys Ala His Gin Tyr Ala Leu Thr Leu Thr Leu Ile Ser Phe Ser 195 200 205 Leu Leu Phe Val Thr Leu Phe Leu Asn Lys Lys Gin Ser Ser Phe Leu 210 215 220 INFORMATION FOR SEQ ID NO:454: SEQUENCE CHARACTERISTICS: LENGTH: 131 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...131 S• (xi) SEQUENCE DESCRIPTION: SEQ ID NO:454 Met His Pro Ile Met Phe Ala Tyr Ile Ala Asn Ala Leu Ala Gin Ala 1 5 10 Arg Lys Ile Asn Gly Thr Leu Cys Met Ala Phe Gin Lys Ile Ser Gin 20 25 Val Lys Glu Leu Gly Ile Asp Lys Ala Lys Ser Leu Ile Gly Asn Leu 40 Ser Gin Val Ile Ile Tyr Pro Thr Lys Asp Thr Asp Glu Leu Ile Glu 55 Cys Gly Val Pro Leu Ser Asp Ser Glu Ile Asn Phe Leu His Asn Thr 70 75 Asp Met Arg Ala Arg Gin Val Leu Val Lys Asn Ile Val Thr Asn Ala 85 90 Ser Ala Phe Ile Glu Ile Asp Leu Lys Lys Ile Cys Lys Asn Tyr Phe 100 105 110 Ile Phe Leu Ile Ala Met Leu Val Ile Glu Lys Ser Ser Met Ile Leu 115 120 125 Lys Lys Gin 130 INFORMATION FOR SEQ ID NO:455: SEQUENCE CHARACTERISTICS: LENGTH: 73 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: 376 ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .73 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:455 Cys Leu Thr Gly Gly Leu Met Arg Trp Leu Lys Ser Val Lys Pro 10 Arg Ile Leu His Ser Val Val Glu Phe Val Asp Ile Ala Gly Leu .25 Lys Gly Ala Ser Lys Gly Glu Gly Leu Gly Asn Gin Phe Leu Ala 40 Ile Lys Glu Cys Glu Val Ile Leu Gin Val Val Arg Cys Phe Glu 55 Asp Asn Asn His Ala Cys Glu Arg Met Giu Ile Asn Asp INFORMATION FOR SEQ ID NO:456: SEQUENCE CHARACTERISTICS: LENGTH: 92 amino acids TYPE: amino acid TOPOLOGY: linear
S.
4 5
S
@4
S
@5S* S
S.
5 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 92 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:456 His Val Ala Cys Leu Leu Ala Leu Gly Asp 5 10 Leu Leu Lys Giu Ile Ala Sen Lys Gin Gin 20 25 1 Giy Thi His Leu Thr Leu Lys Ile Aia Lys 40 sHis Phe Giu Ile Ile Pro Val Phe Giu Asn 55 p Leu Lys Lys Gin Gly Val Phe Trp Ala Met 70 75 ui Leu Lys Gin Leu Lys Asn Ile Lys Sen Asn Met 1 Sel Let Ly~ Asi Lei Asn Leu Ile Thr is Gin Ser Leu Lys Leu Leu Giu Cys Ile Pro Ala Phe Lys Asp Phe Leu Val1 Leu Ile Glu Tyn Trp INFORMATION FOR SEQ ID NO:457: SEQUENCE CHARACTERISTICS: LENGTH: 205 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...205 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:457 Met Lys Lys Lys Pro Leu Met Trp Arg Ile Cys Ala Leu Arg Arg Leu 1 5 10 Leu Leu Gly Phe Lys Arg Glu Arg Glu Leu Leu Ser Phe Ala Lys His 25 Trp Asn Ile Pro Thr Ile Val Val Phe Thr His Thr Gln Ala Glu Ala 40 Gly Asp Ala Phe Val Gin Glu Thr Lys Gly Ile Ile Asp Glu Glu Trp 55 Gly Phe Lys Gly Phe Val Arg Ala Tyr Val Arg Val Asn Ser Val Ala 70 75 Phe Ser Phe Arg Gly Leu Lys Val Pro Val Glu Gly Leu Glu Glu Leu 90 Val Asp Glu Thr Lys Lys Cys Leu Ser Asp Ala Glu Lys Asn Lys Lys 100 105 110 Arg His Phe Leu Ser Iie Gin Arg Val Lys Ile Gin Glu Arg Lys Gin 115 120 125 S Ala Met Ile Glu Glu Cys Lys Thr Ile Ile His Val Ala Ser Gly Ala 130 135 140 Ala Gly Val Ala Gly Leu Ile Pro Ile Pro Phe Ser Asp Ala Leu Ala S* 145 150 155 160 Ile Ala Pro Ile Gin Ala Gly Met Ile Tyr Lys Met Asn Asp Ala Phe 165 170 175 Gly Met Asp Leu Asp Lys Ser Val Gly Ala Ser Leu Val Ala Gly Leu 180 185 190 Leu Gly Val Asn Cys Arg Ala Ser Gly Glu Asp Ser Arg 195 200 205 INFORMATION FOR SEQ ID NO:458: SEQUENCE CHARACTERISTICS: LENGTH: 41 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...41 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:458 Val Leu Gly Val Unk Asn Leu Arg Gly Asn Val Phe Pro Leu Ile Ser 1 5 10 Leu Arg Leu Lys Phe Gly Leu Lys Ala Glu Lys Gin Asn Lys Asp Thr 25 Arg Tyr T.eu Val Val Arg His Asn Asp
I
INFORMATION FOR SEQ ID NO:459: SEQUENCE CHARACTERISTICS: LENGTH: 219 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...219 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:459 Val Lys Ser Val Phe Ser Glu Glu Lys Glu Thr Pro Val Thr Lys Glu 1 5 10 Asn Gly Ser Tyr Leu Ile Ala Tyr Asp Pro Leu Asp Gly Ser Ser Val 25 Met Glu Ala Asn Phe Leu Val Gly Thr Ile Ile Gly Val Tyr'Glu Lys 35 40 Asp Tyr Lys Ala Gin Asn Leu Val Ala Ser Leu Tyr Val Val Phe Gly 50 55 His Lys Ile Glu Leu Val Val Ala Leu Glu Glu Val Tyr Arg Tyr Ala 65 70 75 Phe Tyr Gin Asn Lys Phe His Phe Ile Glu Thr Ile Val Leu Glu Asn S: 85 90 Lys Gly Lys Ile Ile Ala Ser Gly Gly Asn Gin Lys Asp Phe Ser Leu 100 105 110 Gly Leu Lys Lys Ala Leu Glu Gly Phe Phe Ala Glu Asn Tyr Arg Leu 115 120 125 Arg Tyr Ser Gly Ser Met Val Ala Asp Val His His Val Leu Val Lys 130 135 140 Lys Gly Gly Met Phe Ser Tyr Pro Gin Lys Lys Leu Arg Lys Leu Phe 145 150 155 160 o Glu Val Phe Pro Leu Ala Leu Met Val Glu Lys Ala Lys Gly Glu Ala 165 170 175 Phe Tyr Phe Asp Lys Gly Val Lys Lys Arg Leu Leu Asp Gin Ser Val 180 185 190 Glu Ser Tyr His Glu Lys Ser Glu Cys Tyr Leu Ala Ser Pro His Glu 195 200 205 Ala Gin Ile Leu Glu Lys His Leu Lys Gly Glu 210 215 INFORMATION FOR SEQ ID NO:460: SEQUENCE CHARACTERISTICS: LENGTH: 188 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscjfeature LOCATION .188 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:460 Met Lys Ser Ile Gly GiU Val Met Ala Ile Gly Gly Asri Phe Leu Glu 1 5 10 Ala Leu Gln Lys Ala Leu Cys Ser Leu Glu Asn Asn Trp Leu Gly Phe 25 Giu Ser Leu Ser Lys Asp Leu Giu Ala Ile Lys Lys Giu Ile Arg Arg 40 Pro Asn Pro Lys Arg Leu Leu Tyr Ile Ala Asp Ala Phe Arg Leu Gly 55 Val Ser Val Asp Glu Val Phe Giu Leu Cys Gin Ile Asp Arg Trp Phe 70 75 Leu Ser Gin Ile Gin Lys Leu Val Lys Ala Giu Giu Gly Ile Asn Ser 90 Ser Vai Leu Thr Asp Ala Lys Lys Leu Arg Gly Leu Lys Asn Leu Giy 100 105 110 Phe Ser Asp Ala Arg Ile Ala Thr Lys Ile Lys Giu Asn Giu Asn Leu 115 120 125 Giu Val Ser Pro Phe Glu Val Giu Leu Ala Arg Ser Asn Leu Gin Ile 130 135 140 .0000, Ala Pro His Phe Giu Giu Val Asp Thr Cys Ala Al.a Giu Phe Leu Ser 145 150 155 160 Leu Thr Leu Ile Cys Ile Pro Pro Met Pro Leu Thr Leu Cys Pro Leu 165 170 175 Leu Giu Thr Asn Lys Lys Asn Lys Lys Arg Lys Ser :180 185 INFORMATION FOR SEQ ID NO:461: SEQUENCE CHARACTERISTICS: LENGTH: 231 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein 0 (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc_feature LOCATION .231 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:461 Met Phe Gly Asn Lys Gin TLeu Gin Leu Gin Ile Ser Gin Lys Asp Ser 1 5 10 Glu Ile Ala Giu Leu Lys Lys Giu Val Asn Leu Tyr Gin Ser Leu Leu 25 *Asn Leu Cys Leu His Giu Gly Phe Val Gly Ile Lys Asn Asn Lys Val 40 Val Phe Lys Sen Gly Asn Leu Ala Ser Leu Asn Asn Leu Giu Glu Gin 55 Sen Val His Phe Lys Giu Asn Ala Giu Ser Val Asn Leu Gin Gly Val 70 75 Ser Tyn Ser Leu Lys Ser Gin Asn Ile Asp Gly Val Gin Tyr Phe Ser 90 Leu Ala Lys Lys Thr Gly Gly Val Gly Giu Tyr His Lys Asn Asp Leu 100 105 110 380 Phe Lys Thr Phe Cys Thr Ser Leu Lys Glu Gly Leu Glu Asn Ala Gln 115 120 125 Glu Ser Met Gin Tyr Phe His Gin Glu Thr Gly Leu Leu Leu Asn Ala 130 135 140 Ala Lys Asn Gly Glu Glu His Ser Asn Glu Gly Leu Ile Thr Val Asn 145 150 155 160 Lys Thr Gly Gin Asp Ile Glu Ser Leu Tyr Glu Lys Met Gin Asn Ala 165 170 175 Thr Ser Leu Ala Asp Ser Leu Asn Gin Arg Ser Asn Glu Ile Thr Gin 180 185 190 Val Ile Ser Leu Ile Asp Asp Ile Ala Glu Gin Thr Asn Leu Leu Ala 195 200 205 Leu Asn Ala Ala Ile Glu Ala Ala Arg Ala Val Asn Met Ala Glu Gly 210 215 220 Leu Arg Trp Trp Leu Met Arg 225 230 INFORMATION FOR SEQ ID NO:462: SEQUENCE CHARACTERISTICS: LENGTH: 63 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES r (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...63 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:462 Met Trp Ile Met Ser Ser Leu Ser Ser Ser Phe Phe His Ser Leu Phe 1 5 10 Phe Ile Lys Ser Asn Pro Gly Gin Leu Leu Lys Gly Trp Gly Ser Lys -e 20 25 Ile Phe Phe Ile Asn Arg Lys Phe Val Leu Ala Gin Tyr Asn Pro Ser 35 40 Val Ser Ile Phe Ile Leu Leu Asn Arg Val Phe Gly Val Gly Val 55 INFORMATION FOR SEQ ID NO:463: SEQUENCE CHARACTERISTICS: LENGTH: 182 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...182 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:463 Met Gin Phe Giu Giu Met Lys GiU Leu Ala His Gin Ile Gly Val Phe 1 5 10 Tyr His Val Gly Val Asp Gly Ile Ala Leu Phe Leu Leu Leu Leu Asn 25 Ala Ile Val Val Leu Leu Ser Val Val Tyr Val Lys Giu Arg Arg Lys 40 Asp Phe Val Ilie Cys Leu Leu Leu Leu Unk Giy Ile Leu Met Giy Vai 55 Phe Ser Ser Leu Asn Val Ile Phe Phe Tyr Ala Phe Trp Giu Ilie Ser 70 75 Leu Leu Pro Val Leu Tyr Leu Ile Gly Arg Phe Giy Arg Asn Asn Lys 90 Ile Tyr Ser Giy Met Lys Phe Phe Leu Tyr Thr Phe Leu Aia Ser Leu 100 105 110 Cys Met Leu Leu Gly Ile Leu Tyr Ile GJly Tyr Asp Tyr Ala Asn Asn 115 120 125 Tyr Giy Met Met Ser Phe Asp Ile Leu Asp Trp Tyr Gin Leu Asn Phe 130 135 140 Ser Ser Giy Ilie Lys Thr Trp Leu Phe Val Ala Phe Leu Ile Gly Ile 145 150 155 160 Ala Vai Lys Ile Pro Leu Phe Pro Phe Thr His Gly Cys Leu Met Arg 165 170 175 Ile Leu Thr Pro Pro Leu 180 INFORMATION FOR SEQ ID NO:463: SEQUENCE CHARACTERISTICS: LENGTH: 182 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .182 SEQUENCE DESCRIPTION: SEQ ID NO:463 Met Gin Phe Glu Glu Met Lys Giu Leu Ala His Gin Ile Gly Val Phe 1 5 10 Tyr His Val Gly Val Asp Gly Ile Ala Leu Phe Leu Leu Leu Leu Asn 25 Ala Ile Val Val Leu Leu Ser Val Val Tyr Val Lys Glu Arg Arg Lys 40 Asp Phe Val Ile Cys Leu Leu Leu Leu Unk Gly Ile Leu Met Gly Val s0 55 Phe Ser Sen Leu Asn Val Ile Phe Phe Tyr Ala Phe Trp Giu Ile Sen 70 75 Leu Leu Pro Val Leu Tyr Leu Ile Gly Ang Phe Gly Ang Asn Asn Lys 90 Ile Tyr Ser Gly Met Lys Phe Phe Leu Tyr Thr Phe Leu Ala Ser Leu 100 105 1.10 Cys Met Leu Leu Gly Ilie Leu Tyr Ile Gly Tyr Asp Tyr Ala Asn Asn 115 120 125 382 Tyr Gly Met Met Ser Phe Asp Ile Leu Asp Trp Tyr Gin Leu Asn Phe 130 135 140 Ser Ser Gly Ile Lys Thr Trp Leu Phe Val Ala Phe Leu Ile Gly Ile 145 150 155 160 Ala Val Lys Ile Pro Leu Phe Pro Phe Thr His Gly Cys Leu Met Arg 165 170 175 Ile Leu Thr Pro Pro Leu 180 INFORMATION FOR SEQ ID NO:464: SEQUENCE CHARACTERISTICS: LENGTH: 116 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...116 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:464 Val Lys Lys Tyr Ala Glu Asp Phe Ile Thr Lys Asp Glu Val Lys Ser S1 5 10 Leu Leu Glu Arg Leu Ala Lys Asp Tyr Pro Thr Ile Val Glu Glu Ser 20 25 Lys Lys Ile Pro Thr Gly Ala Ile Arg Ser Val Leu Gin Ala Leu Leu 40 His Glu Lys Ile Pro Ile Lys Asp Met Leu Thr Ile Leu Glu Thr Ile 50 55 Thr Asp Ile Ala Pro Leu Val Gin Asn Asp Val Asn Ile Leu Thr Glu 65 70 75 Gin Val Arg Ala Arg Leu Ser Arg Val Ile Thr Asn Ala Phe Lys Ser 90 Glu Asp Gly Arg Leu Lys Phe Leu Thr Phe Ser Thr Asp Unk Glu Gin 100 105 110 Phe Unk Ala Gin 115 INFORMATION FOR SEQ ID NO:464: SEQUENCE CHARACTERISTICS: LENGTH: 116 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...116
-M
(xi) SEQUENCE DESCRIPTION: SEQ ID NO:464 Val Lys Lys Tyr Ala Glu Asp Phe Ile Thr Lys Asp Glu Val Lys Ser 1 5 10 Leu Leu Glu Arg Leu Ala Lys Asp Tyr Pro Thr Ile Val Glu Glu Ser 25 Lys Lys Ile Pro Thr Gly Ala Ile Arg Ser Val Leu Gln Ala Leu Leu 40 His Glu Lys Ile Pro Ile Lys Asp Met Leu Thr Ile Leu Glu Thr Ile 55 Thr Asp Ile Ala Pro Leu Val Gin Asn Asp Val Asn Ile Leu Thr Glu 70 75 Gin Val Arg Ala Arg Leu Ser Arg Val Ile Thr Asn Ala Phe Lys Ser 90 Glu Asp Gly Arg Leu Lys Phe Leu Thr Phe Ser Thr Asp Unk Glu Gin 100 105 110 Phe Unk Ala Gin 115 INFORMATION FOR SEQ ID NO:465: SEQUENCE CHARACTERISTICS: LENGTH: 153 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...153 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:465 Val Gly Ala Asn Pro Val Pro His Ala Gin Ile Leu Gin Ser Val Val 1 5 10 *Asp Asp Leu Lys Glu Lys Gly Ile Lys Leu Val Ile Val Ser Phe Thr 25 Asp Tyr Val Leu Pro Asn Leu Ala Leu Asn Asp Gly Ser Leu Asp Ala 35 40 S* Asn Tyr Phe Gin His Arg Pro Tyr Leu Asp Arg Phe Asn Leu Asp Arg 55 Lys Met His Leu Val Gly Leu Ala Asn Ile His Val Glu Pro .Leu Arg 70 75 Phe Tyr Ser Gin Lys Ile-Thr Asp Ile Lys Asn Leu Lys Lys Gly Ser 90 Val Ile Ala Val Pro Asn Asp Pro Ala Asn Gin Gly Arg Ala Leu Ile 100 105 110 Leu Leu His Lys Gin Gly Leu Ile Ala Leu Lys Asp Pro Ser Asn Leu 115 120 125 Tyr Ala Thr Glu Phe Asp Ile Val Lys Asn Pro Tyr Asn Ile Lys Ile 130 135 140 Lys Pro Leu Glu Ala Ala Val Ile Ala 145 150 INFORMATION FOR SEQ ID NO:466: I I SEQUENCE CHARACTERISTICS: LENGTH: 43 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...43 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:466 Met Gly Leu Val Ala Ser Gly Ile Asn Asp Glu Glu Leu Leu Lys Trp 1 5 10 Leu Gin Ala Phe Gly Leu Lys Met Gly Leu Cys Phe Gin Val Leu Asp 25 Asp Ile Ile Asp Val Thr Gin Asp Glu Lys Glu INFORMATION FOR SEQ ID NO:467: SEQUENCE CHARACTERISTICS: LENGTH: 240 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...240 *o.
(xi) SEQUENCE DESCRIPTION: SEQ ID NO:467 Met Met Lys Asn Lys Arg Ser Gin Asn Ser Pro Tyr Val Thr Pro Asp 1 5 10 Asn Pro Tyr Leu Thr Leu Glu Lys Ala Leu Gly Tyr Ser Phe Lys Asp 25 Lys Arg Leu Leu Glu Gin Ala Leu Thr His Lys Ser Cys Lys Leu Ala 40 Leu Asn Asn Glu Arg Leu Glu Phe Leu Gly Asp Ala Val Leu Gly Leu 55 Val Ile Gly Glu Leu Leu Tyr His Lys Phe Unk Unk Unk Asp Gly Gly 70 75 Lys Leu Ser Lys Leu Arg Ala Ser Ile Val Ser Ala His Gly Phe Thr 90 Lys Leu Ala Lys Ala Ile Ala Leu Gin Asp Tyr Leu Arg Val Ser Ser 100 105 110 Ser Glu Glu Ile Ser Lys Gly Arg Glu Lys Pro Ser Ile Leu Ser Ser 115 120 125 Ala Phe Glu Ala Leu Met Ala Gly Val Tyr Leu Glu Ala Gly Leu Ala 130 135 140 Lys Val Arg Lys Ile Ile Gln Asn Leu Leu Asn Arg Ala Tyr Lys Arg 145 Leu Leu Glu Gin Glu 225 Asp Thr Lys Asp 210 Gin Leu Glu His 165 Gin Unk Gin 180 Gly Pro Asp 195 Lys Met Tyr Gin Cys Ala 150 Leu Phe Met Asp Tyr 170 Phe Cys Val Ile Pro 185 His His Lys Glu Phe 200 Ala Thr Ala Lys Gly 215 Tyr Gin Ala Leu Gin 230 385 155 Lys Thr Ala Leu Gin 175 Thr Tyr Gin Leu Leu 190 Glu Met Ala Leu Tyr 205 Lys Ser Lys Lys Glu 220 Asn Leu Arg Lys Pro 235 160 Glu Gin Ile Ala Asn 240 INFORMATION FOR SEQ ID NO:467: SEQUENCE CHARACTERISTICS: LENGTH: 240 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...240 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:467 Met Met Lys Asn Lys Arg Ser Gin Asn Ser Pro Tyr 1 5 10 Asn Pro Tyr Leu Thr Leu Glu Lys Ala Leu Gly Tyr Val Thr Pro Asp Ser Lys 25 Arg Leu Leu Glu Gin Ala Leu Thr His Lys Leu Val 65 Lys Lys Ser Ala Lys 145 Leu Leu Glu Gin Glu 225 Asn Asn Glu Ile Leu Leu Glu Phe 130 Val Asp Thr Lys Asp 210 Gln Gly Ser Ala Glu 115 Glu Arg Leu Gin Gly 195 Lys Gin Glu Lys Lys 100 Ile Ala Lys Glu Unk 180 Pro Met Cys Arg Leu Leu 85 Ala Ser Leu Ile His 165 Gin Asp 40 Leu Glu Phe 55 Leu Tyr His 70 Arg Ala Ser Ile Ala Leu Lys Gly Arg 120 Met Ala Gly 135 Ile-Gln Asn 150 Leu Phe Met Phe Cys Val His His Lys Leu Lys Ile Gin 105 Glu Val Leu Asp Ile 185 Gly Phe Val 90 Asp Lys Tyr Leu Tyr 170 Pro Asp Unk 75 Ser Tyr Pro Leu Asn 155 Lys Thr Ser Cys Ala Val Unk Unk Ala His Leu Arg Ser Ile 125 Glu Ala 140 Arg Ala Thr Ala Tyr Gin Met Ala 205 Ser Lys 220 Leu Arg Phe Lys Leu Asp Gly Val 110 Leu Gly Tyr Leu Leu 190 Leu Lys Lys Lys Leu Gly Gly Phe Ser Ser Leu Lys Gin 175 Leu Tyr Glu Pro Asp Ala Leu Gly Thr Ser Ser Ala Arg 160 Glu Gin Ile SAla Asn 240 Glu Phe Glu Tyr Ala Thr 215 Ala Tyr Gin 230 Ala Lys Gly Lys Ala Leu Gin Asn 235
I
INFORMATION FOR SEQ ID NO:468: SEQUENCE CHARACTERISTICS: LENGTH: 209 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...209 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:468 Met Gly Phe Asn Arg Leu Val Asp Arg Asp Ile Asp Lys Asp Asn Pro 1 5 10 Arg Thr Lys Asn Arg Pro Ser Val Asp Gly Arg Ile Ser Val Lys Gly 25 Met Val Ile Phe Ser Val Ser Asn Ala Leu Leu Phe Val Gly Val Ser 40 Tyr Phe Ile Asn Pro Leu Ala Phe Lys Leu Ser Leu Pro Phe Leu Ile 50 55 Ile Leu Gly Gly Tyr Ser Tyr Phe Lys Arg Phe Ser Ser Leu Ala His 65 70 75 Phe Val Val Gly Leu Ala Leu Gly Leu Ala Pro Ile Ala Gly Ser Val S* 85 90 Ala Val Leu Gly Asp Ile Pro Leu Trp Asn Val Phe Leu Ala Leu Gly 9. 100 105 110 Val Met Leu Trp Val Ala Gly Phe Asp Leu Leu Tyr Ser Leu Gin Asp 115 120 125 Met Glu Phe Asp Lys Glu Arg Gly Leu Phe Ser Ile Pro Ser Gin Leu 130 135 140 Gly Glu Lys Trp Cys Leu Asn Leu Ser Arg Leu-Ser His Leu Val Ala 145 150 155 160 Leu Ile Cys Trp Leu Cys Phe Val Lys Cys Tyr His Gly Gly Leu Phe 165 170 175 Ala Tyr Leu Gly Leu Gly Val Ser Ala Leu Ile Leu Leu Tyr Glu Gin 180 185 190 Ile Leu Val Ala Arg Asp Tyr Lys Asn Ile Pro Lys Ser Leu Phe Cys 195 200 205 Glu INFORMATION FOR SEQ ID NO:469: SEQUENCE CHARACTERISTICS: LENGTH: 95 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE:
III
NAME/KEY: misc_feature LOCATION 1...95 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:469 Val Glu Gin Asn Lys Ile Ile Lys Leu Phe Thr Val Ala Thr Met Ala 1 5 10 Met Met Pro Pro Thr Leu Ile Gly Thr Ile Asn Gly Met Asn Phe Lys 25 Phe Met Pro Glu Leu Glu Trp Gin Tyr Gly Tyr Leu Phe Ala Leu Ile 40 Val Met Ala Ile Ser Thr Ile Leu Pro Val Ile Tyr Phe Lys Lys Lys 55 Gly Leu Val Val Ala Phe His Gly Ile Phe Ile Leu Thr Leu Arg Arg 70 75 Ser Phe Tyr Thr Ala Trp His Ser Leu Leu Gly Tyr Ala Thr Leu 90 INFORMATION FOR SEQ ID NO:470: SEQUENCE CHARACTERISTICS: LENGTH: 228 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...228 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:470 SLeu Leu Val Leu Leu Asn Leu Lys Unk Thr Pro Asn Leu Met Trp Pro 1 5 10 SLeu Asp Ile Ile Val Val Val Ala Trp Val Leu Trp Gly Val Asn Met 25 Phe Gly Ser Met Ser Val Arg Arg Glu Asn Thr Ile Tyr Val Ser Leu 35 40 Trp Tyr Tyr Ile Ala Thr Tyr Val Gly Ile Ala Val Met Tyr Ile Phe 55 Asn Asn Leu Ser Ile Pro Thr Tyr Phe Val Ala Asp Met Gly Ser Val 70 75 Trp His Unk Ile Ser Met Tyr Ser Gly Ser Asn Asp Ala Leu Ile Gin 90 Trp Trp Trp Gly His Asn Ala Val Ala Phe Val Phe Thr Ser Gly Val 100 105 110 Ile Gly Thr Ile Tyr Tyr Phe Leu Pro Lys Glu Ser Gly Gin Pro Ile 115 120 125 Phe Ser Tyr Lys Leu Thr Leu Phe Ser Phe Trp Ser Leu Met Phe Val 130 135 140 Tyr Ile Trp Ala Gly Gly His His Leu Ile Tyr Ser Thr Val Unk Asp 145 150 155 160 Unk Val Gin Thr Leu.Ser Ser Unk Phe Ser Val Val Leu Ile Leu Pro 165 170 175 Ser Unk Gly Thr Ala Ile Asn Met Leu Leu Unk Met Arg Gly Gin Trp 180 185 190 His Gin Unk Lys Glu Ser Pro Leu Ile Lys Phe Leu Val Leu Ala Ser 195 200 205 388 Thr Phe Tyr Met Leu Ser Thr Leu Giu Gly Ser Ile Gin Ala Ile Lys 210 215 220 Ser Val Asn Ala 225 INFORMATION FOR SEQ ID N0:470: Wi SEQUENCE CHARACTERISTICS: LENGTH: 228 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 228 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:470 Leu Leu Val Leu Leu a.
S
I
Leu Phe Trp Asn.
Tz-p Trp Ile Phe Tyr 145 Unk Sen His Thr Ser 225 Asp Ile Ile Gly Sen Met Tyn Tyr Ile so Asn Leu Ser His Unk Ile Trp Trp Gly 100 Gly Thn Ile 115 Sen Tyr Lys 130 Ile Trp Ala Val Gin Thn Unk Gly Thr 180 Gin Unk Lys 195 Phe Tyr Met 210 Val Asn Ala Val1 Ser Ala Ile Sen His Tyr Leu Gly Leu 165 Aia G lu Leu Asn Leu Lys Val Val Ala Val1 Thr Pro Met Asn Tyn Thn Gly 150 Sen Unk Thr Pro Asn Trp Ile Val1 Asp Asp Phe Ser Sen 140 Sen Val Met Leu Ile 220 Leu Gly Tyr Met Met Ala Thr Gly 125 Leu Thr Leu Arg Val1 205 Gin Met Trp Pro Val Asn Met Val Ser Leu Tyn Ile Phe Gly Ser Val Leu Ile Gin Sen Gly Val 110 Gin Pro Ile Met Phe Val Val Unk Asp 160 Ile Leu Pro 175 Gly Gin Trp 190 Leu Ala Sen Ala Ile Lys Ile Asn Sen Pro Ser Thr 215 INFORMATION FOR SEQ ID NO:471: SEQUENCE CHARACTERISTICS: LENGTH: 92 amino acids TYPE: amino acid TOPOLOGY: linear 389 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .92 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:471 Phe Asp Ser Ile Val Tyr Phe Phe Asn Lys 10 *Leu Val Leu Val Trp Ile Sen Leu Tyr Leu 25 Phe Leu Tyr Lys Se Ile Val Leu Lys Ile 40 *Gin Ser Leu Ser Asn Ile Leu Asn Gly Ala 55 Phe Met Phe Asn Lys Lys Ang Asn Asp Giu 70 Glu Leu Leu Gin Asp Leu Glu Thr Pro Gly Met Thxr Val Met His Asn Ser Gly Phe Val Val Met Thn Leu Glu Leu Arg Arg Gln Asp Ala Pro Thn Lys Arg Tyr Ser .00.
00 INFORMATION FOR SEQ ID NO:472: SEQUENCE CHARACTERISTICS: LENGTH: 96 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacten pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .96 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:472 Met Ala Met Leu Tyr Cys Met Arg Leu Leu Met Pro 1 5 10 Ile Lys Gly Gly Asp Ile Gly Giu Trp Phe Pro Asp 25 Tyr Lys Asn Ala Ser Ser Lys Giu Leu Leu Lys Ile 40 Ser Gin Ser Ile Gly Phe Giu Leu Leu Glu Met Gly 55 Ser Glu Ile Pro Lys Ile Thr Pro Tyr Lys Pro Ala 70 Leu Ser Gin Leu Leu Giy Leu Glu Lys Ser Gin Ile Ile Asn Val1 Ala Ile Ser Leu Asp Leu Thr Leu Leu Gly Pro Asp Ile G iU Lys INFORMATION FOR SEQ ID NO:473: SEQUENCE CHARACTERISTICS: LENGTH: 1178 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...1178 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:473 Met Ile Pro Asn Leu Asp Ile Glu Gly Glu Thr Met Thr Asn Glu Ala 1 5 10 Ile Asn Gin Gin Pro Gin Thr Glu Ala Ala Phe Asn Pro Gin Gin Phe 25 Ile Asn Asn Leu Gin Val Ala Phe Ile Lys Val Asp Asn Val Val Ala 40 Ser Phe Asp Pro Asn Gin Lys Pro Ile Val Asp Lys Asn Asp Arg Asp 55 Asn Arg Gin Ala Phe Glu Lys Ile Ser Gin Leu Arg Glu Glu Phe Ala 70 75 Asn Lys Ala Ile Lys Asn Pro ThrLys Lys Asn Gin Tyr Phe Ser Ser 90 Phe Ile Ser Lys Ser Asn Asp Leu Ile Asp Lys Asp Asn Leu Ile Asp 100 105 110 Thr Gly Ser Ser Ile Lys Ser Phe Gin Lys Phe Gly Thr Gin Arg Tyr 115 120 125 Gin Ile Phe Met Asn Trp Val Ser His Gin Asn Asp Pro Ser Lys Ile 130 135 140 Asn Thr Gin Lys Ile Arg Gly Phe Met Glu Asn Ile Ile Gin Pro Pro 145 150 155 160 Ile Ser Asp Asp Lys Glu Lys Ala Glu Phe Leu Arg Ser Ala Lys Gin 165 170 175 Ala Phe Ala Gly Ile Ile Ile Gly Asn Gin Ile Arg Ser Asp Gin Lys 180 185 190 Phe Met Gly Val Phe Asp Glu Ser Leu Lys Giu Arg Gin Glu Ala Glu 195 200 205 Lys Asn Gly Glu Pro Asn Gly Asp Pro Thr Gly Gly Asp Trp Leu Asp S210 215 220 Ile Phe Leu Ser Phe Val Phe Asn Lys Lys Gin Ser Ser Asp Leu Lys 225 230 235 240 Glu Thr Leu Asn Gin Glu Pro Val Pro His Val Gin Pro Asp Val Ala 245 250 255 Thr Thr Thr Thr Asp Ile Gin Ser Leu Pro Pro Glu Ala Arg Asp Leu 260 265 270 Leu Asp Glu Arg Gly Asn Phe Ser Lys Phe Thr Leu Gly Asp Met Asn 275 280 285 Met Leu Asp Val Glu Gly Val Ala Asp Ile Asp Pro Asn Tyr Lys Phe 290 295 300 Asn Gin Leu Leu Ile His Asn Asn Ala Leu Ser Ser Val Leu Met Gly 305 310 315 320 Ser His Asn Gly Ile Glu Pro Glu Lys Val Ser Leu Leu Tyr Gly Asn 325 330 335 Asn Gly Gly Pro Glu Ala Arg His Asp Trp Asn Ala Thr Val Gly Tyr 340 345 350 Lys Asn Gin Arg Gly Asp Asn Val Ala Thr Leu Ile Asn Val His Met 355 360 365 Lys Asn Gly Ser Gly Leu Val Ile Ala Gly Gly Glu Lys Gly Ile Asn 370 375 380 Asn Pro Ser Phe Tyr Leu Tyr Lys Glu Asp Gin Leu Thr Gly Ser Gin a a 385 Arg 1 Phe Lys Ala Lys 465 Leu Asp Val Ser Ala 545 Leu Ala Leu Ala Ala 625 Lys.
Met Leu Gin Ile 705 Asn Leu Lys Asn Ser 785 Asn Gly Leu Ser Gly 865 Ser kla eu ilu Tyr 150 ksp Ser Arg Met Pro 530 Gly Ala Lys Ser Val 610 Gin Asp Glu Ile Asn 690 Asn Gly Lys Val Lys 770 Ile Leu Val Ala Ala 850 Asn Asp Leu S Ala C 4 Lys 1 435 Leu 2 Lys I Tyr Glu 2 Phe 515 Asp I Phe Ile Gly Ser 595 Ala Lys Val Ala Asn 675 Leu Lys Lys Gly Glu 755 Asp Lys Asn Glu G Gln 835 Leu Gly Ile er 1 n 120 ?he ksp .ys [hr kla 500 Ial ys Ser rhr Leu 580 A.sn Glu ksp Ala Lys 660 Lys Lys Asp Asn Ser 740 Asn Phe Asp Gin Gin 820 Gin Tyr Leu Lys Gin 405 Asn Gin Ala His Leu 485 Lys Asp Gly Lys Ser 565 Ser Lys Ala Leu Lys 645 Ser Glu Gly Leu Lys 725 Val Leu Ser Val Ala 805 Ala Ala Gir Ser Lys 885 390 Glu C Asn 2 Asn Leu Leu 2 470 Lys 2 Thr Tyr Val Val 550 Val Pro Glu Lys Glu 630 Asn Gin Ala Ile Lys 710 Asp Lys Asn Lys Ile 790 Val Leu Gin Ser Lys 870 Glu ;lu kla ;lu ly 155 %la ksp rhr Ser Gly 535 Ala Val Gin Leu Asn 615 Lys Leu Ala Asn Lys 695 Asp Phe Asp Ala Val 775 Ile er Ala Lys Va1 855 Ala Leu Ile C Lys I Ile C 440 Asn 2 Leu Tyr C Leu Asn 520 Ala Val Arg Glu Val 600 Thr Ser Glu Asn Arg 680 Arg Phe Ser Leu Ala 760 Thr Asn Va1 Asp Asn 840 Lys Glu Asn ln 2 eu 2 125 Uu 2 %sp I Ial 2 Uly ~l 505 Phe rhr Phe Gin Ala 585 Gly Gly Leu Ser Ser 665 Asp Glu Ser Lys Cly 745 Leu Gin Gin Ala Leu 825 Glu Asn Ala Ala sn 110 ksp ksp His kla Lys 490 .ly Lys Asn Asn Aso 570 Asn Lys Asn Lys Lys 650 Gin Ala Leu Lys Ala 730 Ile Asn Ala Lys Lys 810 Lys Asp G ij Thi Lyz 89( 395 Lys Asn I Phe C Ile 2 Glu I 475 Lys 2 Ser I Tyr Gly Leu 555 Leu Lys Ala Tyr Lys 635 Ser Lys Arg Ser Ser 715 Glu Asn Glu Lys Ile 795 Ala Asn Phe Val Thr 875 Leu a 1 jeu ln kla 160 ?he kla eu [hr Ja1 540 Pro Glu Leu Leu Asp 620 Arg Gly Asp Ala Asp 700 Phe Glu Pro Phe Ser 780 Thr Thr Phe Asn Asn 860 Leu GlN Asp Ser Lys 445 Phe Gly Asp Lys Asn 525 Ser Asn Asp Va1 Asn 605 Glu Glu Asn Glu Ile 685 Lys Asp Thr Glu Lys 765 Asp Asp Gly Ser Thr 845 Gly Ser Asn Phe Lys 430 Asp Val Asn Lys His 510 Ala His Leu Lys Lys 590 Phe Val Arg Lys Ile 670 Ala Leu Glu Leu Trp 750 Asn Leu Lys Asp Lys 830 Gly Thr Lys Phe Met 415 Lys Ser Ser Gly Ala 495 Asp Ser Leu Asn Leu 575 Asp Asn Lys Leu Asn 655 Phe Tyr Glu Phe Lys 735 Ile Gly Glu Val Phe 815 Glu Lys Leu Asn Asr 895 400 Glu Glu Lys Lys Glu 480 Leu Gly Lys Glu Asn 560 Ile Phe Lys Gin Glu 640 Lys Ala Ala Asn Lys 720 Ala Ser Lys Asn Asp 800 Ser Gin Asn Val Phe 880 Asn Asn Asn Asn Asn Gly Leu Glu Asn Ser Thr Giu Pro Ile 900 905 Tyr Thr Gin 910 Val Ala Lys Lys Val Lys Ala Lys Ile Asp Arg Leu Asp Gin Ile Ala 915 920 925 Ser Gly Leu Gly Asp Val Gly Gin Ala Ala Ser Phe Leu Leu Lys Arg 930 935 940 His Asp Lys Val Asp Asp Leu Ser Lys Val Gly Leu Ser Ala Asn His 945 950 955 960 Glu Pro Ile Tyr Ala Thr Ile Asp Asp Leu Gly Gly Pro Phe Pro Leu 965 970 975 Lys Arg His Asp Lys Val Asp Asp Leu Ser Lys Val Gly Leu Ser Arg 980 985 990 Glu Gin Lys Leu Thr Gin Lys Ile Asp Asn Leu Asn Gin Ala Val Ser 995 1000 1005 Glu Ala Lys Ala Ser His Phe Asp Asn Leu Asp Gin Met Ile Asp Lys 1010 1015 1020 Leu Lys Asp Ser Thr Lys Lys Asn Val Val Asn Leu Tyr Val Glu Ser 1025 1030 1035 1040 Ala Lys Lys Val Pro Thr Ser Leu Ser Ala Lys Leu Asp Asn Tyr Ala 1045 1050 1055 Thr Asn Ser His Thr Arg Ile Asn Ser Asn Val Lys Asn Gly Thr Ile 1060 1065 1070 Asn Glu Lys Ala Thr Gly Met Leu Thr Gin Lys Asn Ser Glu Trp Leu 1075 1080 1085 Lys Leu Val Asn Asp Lys Ile Val Ala His Asn Val Gly Ser Ala Pro 1090 1095 1100 Leu Ser Ala Tyr Asp Lys Ile Gly Phe Asn Gin Lys Asn Met Lys Asp 1105 1110 1115 1120 Tyr Ser Asp Ser Phe Lys Phe Ser Thr Arg Leu Ser Asn Ala Val Lys 1125 1130 1135 Asp Ile Lys Ser Gly Phe Val Gin Phe Leu Thr Asn Ile Phe Ser Met 1140 1145 1150 Gly Ser Tyr Ser Leu Met Lys Ala Ser Val Glu His Gly Val Lys Asn 1155 1160 1165 Thr Asn Thr Lys Gly Gly Phe Gin Lys Ser 1170 1175 INFORMATION FOR SEQ ID NO:474: SEQUENCE CHARACTERISTICS: LENGTH: 162 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...162 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:474 Met Lys Ala Pro Ser Gin Unk Asp Leu Lys Lys Ile Leu Gly Ile Glu 1 5 10 Glu Val Ile Unk Unk Ser Thr Ser Pro Met Glu Leu Arg Leu Ala Asn 25 Gin Lys Leu Gly Asn Arg Phe Ile Lys Thr Leu Gin Ala Met Asn Glu 40 Leu Asp Met Gly Ala Phe Phe Asn Ala Tyr Ala Gln Thr Thr Lys Asp 55 Pro Thr His Ala Thr Ser Tyr Gly Val Phe Ala Ala Ser Leu Asn Met
I
Glu Met Gin Lys Asn 145 Met Lys Lys Ala Leu Arg His Tyr Leu 90 Ile Asn Cys Val Lys Ser Val Pro 100 105 Ile Leu Leu Ser Leu Gin Ser Pro 115 120 Leu Glu Leu Asp Glu Ser His Leu 135 Ile Lys Ala Met Gin His Glu Ser 150 Ala Gin Thr Ser Ser Gin Asn Asp 110 Asn Gin Leu Ile 125 Ala Ala Ser Val 140 Tyr Ser Arg Leu INFORMATION FOR SEQ ID NO:474: SEQUENCE CHARACTERISTICS: LENGTH: 162 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...162 (xi) SEQUENCE DESCRIPTION: SEQ ID N0:474 a Met 1 Glu Gin Leu Pro Glu Met Gin Lys Asn 145 Met Lys Ala Pro Ser Gin Unk Asp Leu Lys Ile Leu Gly Ile Glu Val Lys Asp Thr Leu Val Lys Thr 130 Asp Ser Ile Leu Met His Lys Ile Ile 115 Leu Ile a a f INFORMATION FOR SEQ ID NO:475: SEQUENCE CHARACTERISTICS: LENGTH: 466 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NME/KEY: misc-feature LOCATION .466 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:475 a a.
a *aa.
a. *a a a a a a. a a a. *aa.
*a.a .a a a a Met Ala Pro Lys Gin Val Leu Ala Asn Cys 145 Lys Thr Ser Giu Gin 225 Thr Ile Gin Phe Asn 305 Arg Ile Lys Gin Gin 385 Pro Lys Aia Leu Lys Thr Phe Leu Lys Ile Thr Trp Asp Asn Sen Lys Tyr 130 Pro Asn Lys Thr Tyr 210 Leu Ala Ala Asp Gly 290 Arg Leu Ala His Asn 370 Ser Ala Ala Gin Ala Thr Asp Ile Gin 115 Asp Glu Leu Ala Aia 195 Ile Leu Tyr Sen Arg 275 Phe Asn
LYS
Gly Ang 355 Leu Asp Leu Asn Lys Leu Val Pro 100 Val1 Ile Leu His Leu 180 As n Cys Asp Glu Asn 260 Ala Asn Gly Ala Lys 340 Phe Ser Ala Ala Asn His Leu Ala Trp Asn His Leu Ala 55 Asp Arg Ala 70 Leu Asn Lys Asn Pro Met Gin Ala Asn Arg Asn Gin 135 Asn Trp Asp 150 Gin Phe Phe 165 Lys Asp Phe Asp Led Gly Ile Gin Lys 215 Sen Gin Met 230 Lys Leu Arg 245 Val Tyr Ala Phe Ser Gin Asp Old Asn -295 Lys Ser Glu 310 Gin Phe Asp 325 Lys Gly Glu Gin Gin Leu Phe Met Asn 375 Phe Lys Gin 390 Led Lys Asp Asn Gly 40 Thr Asn Thr Gin Thr 120 Ile Val Thr Ala Ala 200 Gly Thr Ala Lys Met 280 Val Cys Giu Ala Sen 360 Lys Gin Asp Ala 25 Ala Ile Gin As n Tyr 105 Giu Ala Ser Ser Asn 185 Gly Asn Leu Giu Val1 265 Asp Lys Ile Leu Ala 345 Val Thr Met Lys Lys 10 Val1 Lys Thr Thn Gin 90 Val Arg Ala Gin Lys 170 Ala Leu Leu Ala Lys 250 Lys Asn Lys Pro Asn 330 Ala Gld Leu Gly Glu Ser Leu Ile Ala Met Ile Arg Ala Trp Glu Arg Ile Leu Asn Ser 75 Phe Leu Thr Giu Lys Ile Ile Lys Giu 125 Lys Arg Ile 140 Asp Ala Sen 155 Gly Lys Glu Ile Gly Asn Arg Gly Ang 205 Giu Ala Ala 220 Leu Leu Asn 235 Glu Glu Leu Gin Leu Val Giu Leu Gly 285 Gly Tyr Cys 300 Asn Met Leu 315 Leu Asp Tyr Lys Val Phe Thr Ala Leu 365 Gly Leu Met 380 Tyr Phe Glu 395 His Gin Giu Leu Val1 Asp Lys Ile Gly Gin 110 As n Sen Pro Ser Thr 190 Ala Lys As n Lys Val1 270 Vai Lys Asn Ser As n 350 Glu Val Asp Asn Leu is Asp G lu Leu Asn Ser Ser Ala Giu Thr Ala 175 Gin Leu Lys Asp Arg 255 Ala Lys Lys Val Ang.
335 Asp Ile Gin Ile Leu Leu Asn Ser Ala Lys Ile Phe Gin Lys Giu 160 As n Ile Leu Ile Tyr 240 Gin Ser Thn Giu Asn 320 Asp Tyr Ala Me t Ile 400 Glu 405 410 415 Gin Lys Gin Gin Glu Ile Glu Lys Val Tyr Arg Ala Lys Leu Asp Ala 420 425 430 Tyr Gly Phe Pro Asn Gly Ser Val Gly Lys Ala Ser Gly Val Asn Ser 435 440 445 Asn Ser Asn Asn Glu Ala Pro Ser Ser Asp Asn Ile Gin Ser Phe Asn 450 455 460 Pro Tyr 465 INFORMATION FOR SEQ ID NO:476: SEQUENCE CHARACTERISTICS: LENGTH: 59 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...59 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:476 Met Ala Phe Ile Leu Thr Thr Asn Leu Phe Ile Lys Se r Phe Thr Asn 1 5 10 Ser Ile Arg Ile Thr Gly Cys Ile Ile Ser Pro Asn Val Phe Phe Ala 25 Tyr Glu Phe Cys Ala Leu Gly Phe Arg Lys Gly Gly Leu Ile Leu Asp S* 35 40 Asn Phe Ser Lys Phe Val Ser His Arg Leu Gin 50 INFORMATION FOR SEQ ID NO:476: SEQUENCE CHARACTERISTICS: S(A) LENGTH: 59 amino acids TYPE: amino acid TOPOLOGY: linear 9999 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCEr ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...59 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:476 Met Ala Phe Ile Leu Thr Thr Asn Leu Phe Ile Lys Ser Phe Thr Asn 1 5 10 Ser Ile Arg Ile Thr Gly Cys Ile Ile Ser Pro Asn Val Phe Phe Ala 25 396 Tyr Glu Phe Cys Ala Leu Gly Phe Arg Lys Gly Gly Leu Ile Leu Asp 40 Asn Phe Ser Lys Phe Val Ser His Arg Leu Gln INFORMATION FOR SEQ ID NO:477: SEQUENCE CHARACTERISTICS: LENGTH: 248 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .248 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:477 00.
00 Val Leu Ala Leu Ser Gly Ile Thr Phe Arg 145 Pro Met Leu Met Ile 225 Leu Arg Met Pro Leu so Phe Thr Leu Gly Giu 130 Giu
LYS
Ile Pro Giy 210 Leu Val Ser Ser Thr Thr Gin Thr Ile 115 Lys Lys Thr Ser Phe 195 Met Val Ala Ala Asp Leu Ang GIn Phe 100 Lys Ser Asp Pro Giu 180 Leu Met .Phe Ser Asp Pro Leu Leu Thr Phe Pro Thr Leu Asp 165 Leu Val Met Ile Phe 245 Val Thr Leu Phe Leu Leu Ile Phe Ile 155 Val Ile Ser Ile Asn 235 Phe Phe Ile Phe Leu Ile Leu Ile Cys Pro Asn Leu Ile Leu Val1 .L~ys Ser Met 140 Arg Leu Gly Ser Ser 220 Leu Leu Leu As n Leu Arg Ser Lys Tyr 125 Leu Asn Ile Phe Ile 205 Leu Leu INFORMATION FOR SEQ ID NO:477: SEQUENCE CHARACTERISTICS: LENGTH: 248 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .248 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:477 Val Arg Phe Phe Ile Phe Leu Ile Leu Ile Cys 1 Leu Ala Leu Ser Gly Ile Thr Phe Arg 145 Pro Met Leu Met Ile 225 Leu Met Pro Leu Phe Thr Leu dly G iu 1:30 Giu Lys Ile Pro Gly 210 Leu Val Ser Sen Thr Thr Gin Thr Ile 115 Lys Lys Thr Ser Phe 195 Met Val Ala 5 Ala Asp Asp Pro Leu Leu Arg Leu Gin Thr Phe Phe 100 Lys Pro Sen Thn Asp Leu Pro Asp 165 Giu Leu 180 Leu Val Met Met Phe Ile Ser Phe 245 Sen Lys Val1 Ile 70 Pro Ile Tyr Leu Ala iso Asp Lys Ile Leu Leu 230 Lys Ala Leu Gin Leu 40 Leu Ala 55 Val Val Pro Thr Met Giu Met Asp 120 Pro Phe 135 Leu Phe Val Ser Thr Ala Asp Met 200 Pro Pro 215 Val Asp Met Val Sen Thr S er Sen Ile 90 Ser Lys Giu Arg Sen 170 Gin Ile Met Val1 Thr Leu Phe 75 Leu Leu Ile Phe Ile 155 Val Ile Ser Ile Pro Asn Leu Ile Leu Val1 Lys Sen Met 140 Arg Leu Gly Sen Ser 220 Leu Leu Asn Leu Arg Sen Lys Tyr 125 Leu Asn Ile Phe Ile 205 Leu Ile Ser Val1 Val Thr Leu Ala 110 Thr Lys Leu Pro Leu 190 Leu Pro Cys Leu Ile Met Ala Ser Glu Asn Pro Ala 175 Leu Met Phe Pro Asn Ala Thr Leu Leu Asp Ala Thr Asn 160 Phe Tyr Ala Lys a a a Gly Phe Asn Leu Leu Thr Giu Asn INFORMATION FOR SEQ ID NO:478: SEQUENCE CHARACTERISTICS: LENGTH: 44 -amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1...44 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:478 Val Met Asp Ala Glu Asn Gly Glu Leu Leu Val Ala Gly Ser Tyr Pro 1 5 10 Glu Tyr Asn Leu Asn Asp Phe Val Gly Gly Ile Ser Gin Asp Lys Trp 25 Gin Lys Leu Gin Asp Asp Ile Tyr Asn Pro Leu Leu INFORMATION FOR SEQ ID NO:479: SEQUENCE CHARACTERISTICS: LENGTH: 421 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...421 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:479 Met Asn Phe Phe Asp Thr Leu Met Gly Met Phe Val Glu Pro Ser Gin S 1 5 10 Lys Val Ala Lys Ser Leu Ala Glu His Val Gly Ser Phe Phe His Ala 20 25 S Gin Leu Ile Leu Asn Thr Ile Ile Thr Ile Leu Phe Met Ile Trp Ala 35 40 Tyr Lys Arg Val Lys Glu Gly Asp Met Phe Glu Phe Lys Thr Ala Met 55 Gly Val Val Val Phe Ile Ala Phe Val Gly Phe Ile Asn Trp Gly Ile 70 75 Lys Asn Pro Asn Asp Phe Asn Thr Tyr Phe Ile Asn Thr Ile Phe Tyr 85 90 Pro Ser Glu Lys Leu Ala Ile Leu Ile Ala Gln Ser Leu Asn Asp Gly 100 105 110 Leu Glu Ile Pro Thr Asn Thr Asn Leu Ser Pro Ser Glu Ile Phe Ser 115 120 125 Ile Gly Asn Leu Ala Ser Ser Ala Tyr Ala Met Ile Val Asn Leu Trp 130 135 140 Asp Asn Ala Phe Asp Gly Ile Asn Met Phe Asn Trp Leu Thr Met Ile 145 150 155 160 Pro Lys Ile Ile Met Phe Phe Leu Val Ile Leu Gly Glu Leu Leu Phe 165 170 175 Leu Gly Leu Leu Leu Ile Ile Val Leu Leu Val Thr Ala Glu Ile Phe 180 185 190 Met Trp Ser Ala Leu Gly Leu Ile Val Leu Pro Leu Gly Leu Ile Pro 195 200 205 Gin Thr Lys Gly Met Leu Phe Ser Tyr Leu Lys Lys Leu Ile Ser Leu 210 215 220 Thr Leu Tyr Lys Pro Cys Met Met Leu Val Ala Phe Phe Asn Tyr Gly 225 230 235 240 Ile Ile Tyr Lys Val Asn Thr Leu Ile Pro Thr Lys His Glu Val Thr 245 250 255 Gin Gly Phe Tyr Gly Asn Ala Asp Lys Met Ala Asn Glu Gly Lys Ile 260 265 270 Ile Asp Val. Phe Gly Asn Val Leu Giu Gly Asp Trp Asn Ser Tyr Ile 275 280 285 Ala His Ser Ser Ile Val. Gly Phe Leu Thr Ile Ile Val Leu Gly Ser 290 295 300 Vai Ile Cys Phe Phe Leu Val Lys Arg Vai Pro Asp Phe Ile Asn Asn 305 310 315 320 Ile Phe Gly Thr Ser Gly Giy Val Giy Ala Val Thr Giu Met Met Gin 325 330 335 Lys Ile Gly Met Thr Ile Gly Gly Ala Val Phe Gly Gly Ser Ala Val 340 345 350 Met Val Ala Asn Gin Val Lys Gin Ala Tyr Gin Ser Ala Gly Giy Gly 355 360 -365 Leu Ala Giy Leu Gin Ala Giy Ala Lys Ala Phe Gly Leu Giy Ala Ile 370 375 380 Ser Gly Gly Ala Ser Ala Met Ala Asn His Arg Ser Val Lys Ala Gly 385 390 395 400 Val Lys His Phe Val Ala Ser Val Lys Ser Gly Phe Gly Phe Asp Asn 405 410 415 Asp Lys Asn Asn Lys 420 INFORMATION FOR SEQ ID NO:480: SEQUENCE CHARACTERISTICS: LENGTH: 166 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .166 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:480 .aa *Leu Leu Val Thr Phe Leu Asn Gly Phe Asp Pro Lys Ile Ala Asn Leu 1 5 10 Anrg Lys Ala Cys Asn Val Tyr Ser Vai Gly Val Ile Tyr Ile Va. Thr :*Go20 25 *Thr Msn Thr Leu Asn Ile Leu Ser Cys Glu Ser Phe Glu Ile Leu Giu 40 Lys Arg Giu Leu Asp Thr Ser Gly Va. Thr Lys Thr Sen Thr Pro Phe 55 Phe Ser Arg Va. Glu Gly Ile Asp Ala Gly Thn Leu Gly Lys Leu Phe 70 -75 Ser Gly Sen Gin Sen Lys Asn Ty'r Phe Ala Tyr Tyn Asp Ala Leu Val.
90 Lys Lys Glu Lys Arg Lys Glu Val. Arg Ile Glu Lys Lys Giu Giu Arg 100 105 110 Ile Asp Ala Arg Glu Msn Lys Arg Giu Ile Lys Gin Glu Ala Ile Lys 115 120 125 Giu Pro Lys Lys Ala Msn Gin Gly Thr Glu Asn Ala Pro Thr Leu Giu 130 135 140 Giu Lys Unk Tyr Gin Lys Ala Giu Arg Lys Phe Asp Ala Lys Unk Unk 145 150 155 160 Arg Arg Sen Phe Lys Unk 165 INFORMATION FOR SEQ ID NO:480: SEQUENCE CHARACTERISTICS: LENGTH: 166 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...166 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:480 Leu Leu Val Thr Phe Leu Asn Gly Phe Asp Pro Lys Ile Ala Asn Leu 1 5 10 Arg Lys Ala Cys Asn Val Tyr Ser Val Gly Val Ile Tyr Ile Val Thr 25 Thr Asn Thr Leu Asn Ile Leu Ser Cys Glu Ser Phe Glu Ile Leu Glu 40 Lys Arg Glu Leu Asp Thr Ser Gly Val Thr Lys Thr Ser Thr Pro Phe 55 Phe Ser Arg Val Glu Gly Ile Asp Ala Gly Thr Leu Gly Lys Leu Phe e 65 70 75 Ser Gly Ser Gin Ser Lys Asn Tyr Phe Ala Tyr Tyr Asp Ala Leu Val 85 90 Lys Lys Glu Lys Arg Lys Glu Val Arg Ile Glu Lys Lys Glu Glu Arg 100 105 110 Ile Asp Ala Arg Glu Asn Lys Arg Glu Ile Lys Gln Glu Ala Ile Lys 115 120 125 Glu Pro Lys Lys Ala Asn Gin Gly Thr Glu Asn Ala Pro Thr Leu Glu S130 135 140 Glu Lys Unk Tyr Gin Lys Ala Glu Arg Lys Phe Asp Ala Lys Unk Unk 145 150 155 160 Arg Arg Ser Phe Lys Unk 165 INFORMATION FOR SEQ ID NO:481: SEQUENCE CHARACTERISTICS: *eo* LENGTH: 89 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...89 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:481 Asp Giu Pro Giu Thr Ser Leu Giu Gin Asn 10 Asn Leu Ile Ser Leu Arg Asn Thr Gin Gin 25 Thr His Asp Pro Ile Val Leu Asp Ser Cys 40 Lys Asn Gly Asn Ile Ala Gin Tyr Lys Pro 55 Ser Val Ala Lys Thr Phe Asn Phe Lys Giu 75 Leu Leu Ala Leu Leu Lys Asp Ile Ala Leu Ile Arg Leu is Leu Thr Ser Ile Ile Glu Trp Val Leu Leu Leu Asn Ser Ile Leu Lys Pro Thr Thr Lys INFORMATION FOR SEQ ID NO:482: SEQUENCE CHARACTERISTICS: LENGTH: 237 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION 237 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:482 Val Lys Thr Leu Giy Leu Ser Sen Leu Gly Gly Thn Leu Giu Phe Tyr ess.
0*ee 0S 0*S* 0*
**SU
0S Asp Phe Ile Ala Ile Phe
LYS
Val Tnp 145 Ile Leu Asp Ile Gin 225 Phe Pro Phe 50 His Leu Asn Asn Arg 130 Val Gly Val Trp Sen 210 Ile Asn Ala Phe Leu Asp Ala 115 Ile Phe Phe Tyr Ala 195 Val Ile 20 Thr Ala Gly Met Leu 100 His Cys Val Leu Ile 180 Trp 5 Phe Leu dly Asp Val Val Tyr Gil- His Thi 161 G1~ Arc Lei Val Ser Tyr Lys 70 Sle *Gly *Leu IGly Giu I50 *Ala r Ile I Val i Arg ~Ang 230 Phe Phe Pro Ile 40 Leu Ala 55 Phe Gly Pro Thr Phe Gly Gly Tyr 120 Vai Ala 135 His Ala Sen Val Tyr Met Ala Phe 200 Ang Phe 215 Thr 25 Trp Ang Arg Phe Val 105 Ile Val Pro Val1 Vai 185 Gly Leu 10 Sen Ser Pro Lys Ala 90 Asp Ala Gly Gin Ser 170 Phe Leu Glu Ile Giu Leu Asn 75 Leu Sen Pro Gly Gly 155 Gly Asp Gly Glu Ile Ile Gly Met Ala Met Val Glu 140 Gin Ile Lys Gly Thr 220 Ala Asn Gly Phe Leu Gly Phe 125 Leu Lys Leu Pro Ile 205 Pro Lys Thr Ile Met Met Leu 110 Leu Pro Asn Leu Val 190 Phe Val is His Phe Tyr Gly Val Met Leu Ser Pro Thr Thr Pro Val Leu Gly Ala Thn Tyr 160 Gly Sen 175 Val Giu Gly Ile Phe Gin 0* Met Lys Gin Gil Cys Leu Sen Gin Ile Pro Ala 235 INFORMATION FOR SEQ ID NO:48]: SEQUENCE CHARACTERISTICS: LENGTH: 471 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE:- NAME/KEY: misc-feature LOCATION 1...471 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:483 Met Arg Lys Phe Leu Asp Gly Ala Lys Sen Giu Val Leu Lys Tyr Asp 1 s 10 Val Ile Sen Phe Asp Ile Phe Asp Thr Leu Leu Leu Arg Pro Phe Ile 25 Lys Pro Thr Asp Leu Phe Leu Tyr Ile Giu Thr Lys Tyr Asn Ile Lys 40 Gly Phe His Gin Ala Ang Ile Leu Ala Giu Met Gin Sen Ang Lys Leu so 55 Sen Lys Arg Gln Asp Ile Thr Leu Asp Giu Ile Tyr His Gin Ile Pro 70 75 *Lys Giu Phe His Sen Tyr Lys Gly Val Giu Ile Ala Thn Giu Lys Giu 90 *Val Leu Val Pro Asn Leu Giu Met Leu Giu Leu Tyr Ang Phe Ala Lys .9.100 105 110 Giu Asn Asn Lys Ang Val Ile Ile Val Ser Asp Met Tyr Leu Pro Leu 115 120 125 Giu Val Leu Giu Asp Ile Leu Ile Sen Lys Gly.Phe Asp Gly Tyr Thr 130 135 140 Asn Phe Tyr Leu Ser Asn His Ile Met Leu Thn Lys His Sen Lys Asp 145 150 155 160 Leu Phe Lys His Val Leu Lys Gin Giu Asn Ile Thr Asn Thr Gin Ile 165 170 175 *Leu His Ile Giy Asp Asn Ser Trp Ala Asp Asp Ala Met Pro Lys Sen .9.180 185 190 Leu Gly Ile Ala Thr Leu Phe Arg Lys Sen Val Leu Lys Gin Ltu Glu 195 200 205 Giu Vai Phe Pro Lys Tyr Lys Thn Phe Asn Pro Thr Sen Vai Ala Gin :::210 215 220 Sen Phe Ile Leu Gly Ser Leu Cys Val Phe Tyr Lys Asn Tyr Ile Gin 225 230 235 240 Lys His Glu Lys Phe Asp Tfyr Trp Phe Leu Leu Gly Ala Met Gin Ala 245 250 255 Gly Ile Ala Ala Val Ala Tyr Cys Gin Phe Ile Tyr Lys Glu Ile His 260 265 270 Lys Arg Asn Ile Asp Thr Leu Val Phe Vai Ala Arg Asp Gly Tyr Leu 275 280 285 Leu Gin Lys Ile Phe Asn Ile Leu Tyr Pro Asn Ser Tyr Lys Thn Thr 290 295 300 Tyr Val Tyr Ala Pro Ang Ile Leu Lys Lys Ala Val Phe Lou Glu Val 305 310 315 320 Vai Giu Gly Giu Ser Leu Giu Ile Leu Arg Ile Leu Giu Gly Giu Glu 325 330 335 Giu Val Lys Lys Lys Gin Ile Thr Thn Asn Gin Gin Ala Tyr Val Tyr 340 345 350 Leu Tyr Ser Asn Phe Glu His Cys Arg His Leu Ala Leu Lys Cys Leu 355 360 365 Asp Asn Tyr Arg Lys Tyr Leu Phe Ser Ser Asn Leu Glu Gly Asn Ile 370 375 380 Ala Ile Val Asp Thr Ile Thr Leu Gly Tyr Ser Ser Gin Gly Leu Ile 385 390 395 400 Gin Lys Ala Leu Asn Lys Glu Val Phe Gly Cys Tyr Val Asp Leu Leu 405 410 415 Arg Ile Leu Asn Tyr Asp Cys Val Ser Phe Leu Pro Phe Ser His Pro 420 425 430 Lys Pro Val Tyr Phe His Asn Trp Asp Phe Met Glu Phe Leu Leu Thr 435 440 445 Ser Pro Glu Tyr Pro Ile Leu Asn Val Glu Asn Gly Val Pro Ile Leu 450 455 460 Ser Lys Arg Arg Phe Ile Leu 465 470 INFORMATION FOR SEQ ID NO:484: SEQUENCE CHARACTERISTICS: LENGTH: 123 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...123 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:484 Val Leu Lys Phe Phe Glu Asp Ser Lys Gin Leu Ser Thr Pro Met Gly 1 5 10 Lys Ser Ala Val Gly Ile Leu Ile Phe Gin Asp Ile Ala Ala Ile Pro 25 Met Leu Leu Ile Leu Thr Ile Leu Gly Ser Lys Asp Ser His Val Asn 35 40 ***Leu Leu Ile Leu Lys Thr Leu Ile Ser Ala Gly Ile Ile Leu Ile Leu 50 55 Leu Leu Leu Pro Gly Lys Lys Gly Ala Asn Leu Ile Leu Glu Gin Ala 70 75 f. Lys Asp Thr Arg Leu Pro Glu Ile Phe Ile Gly Thr Asp Phe Ser Asp 90 Cys Leu Gin Arg Gly Gly Val Glu Pro Phe Phe Trp Val Phe Tyr Val 100 105 110 Phe Gly Gly Val His Cys Gly His Gly Asp Phe 115 120 INFORMATION FOR SEQ ID NO:485: SEQUENCE CHARACTERISTICS: LENGTH: 127 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein 404 (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...127 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:485 Met Glu Asn Ser Thr Leu Tyr Ile Val Ile Ala Gly Leu Trp Leu Ala 1 5 10 Val Gly Phe Gly Ile Phe Leu Lys Lys Leu Asp Met Pro Val Ile Ile 25 Gly Tyr Ile Cys Thr Gly Thr Val Leu Ala Ala Phe Phe Lys Ile Asn 40 Asp Phe Asn Leu Leu Ser Asp Ile Gly Glu Phe Gly Ile Val Phe Leu 55 Met Phe Met Ile Gly Ile Glu Phe Asn Phe Asp Lys Leu Lys Ser Ile 70 75 Lys Gin Glu Val Leu Val Phe Gly Leu Leu Gin Val Val Leu Cys Ala 90 Leu Ile Ala Phe Leu Leu Gly Tyr Phe Val Leu Gly Leu Ser Pro Ile 100 105 110 Phe Ser Leu Val Leu Gly Met Gly Leu Ser Leu Ser Ser Thr Ala 115 120 125 INFORMATION FOR SEQ ID NO:485: SEQUENCE CHARACTERISTICS: LENGTH: 127 amino acids i TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori
FEATURE:
NAME/KEY: misc_feature LOCATION 1...127 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:485 Met Glu Asn Ser Thr Leu Tyr Ile Val Ile Ala Gly Leu Trp Leu Ala 1 5 10 Val Gly Phe Gly Ile Phe Leu Lys Lys Leu Asp Met Pro Val Ile Ile 25 Gly Tyr Ile Cys Thr Gly Thr Val Leu Ala Ala Phe Phe Lys Ile Asn 40 Asp Phe Asn Leu Leu Ser Asp Ile Gly Glu Phe Gly Ile Val Phe Leu 55 Met Phe Met Ile Gly Ile Glu Phe Asn Phe Asp Lys Leu Lys Ser Ile 70 75 Lys Gin Glu Val Leu Val Phe Gly Leu Leu Gin Val Val Leu Cys Ala 90 Leu Ile Ala Phe Leu Leu Gly Tyr Phe Val Leu Gly Leu Ser Pro Ile 100 105 110 Phe Ser Leu Val Leu Gly Met Gly Leu Ser Leu Ser Ser Thr Ala INFORMATION FOR SEQ ID NO:486: SEQUENCE CHARACTERISTICS: LENGTH: 259 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...259 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:486 Met 1 Leu Leu Phe Phe Tyr 65 Phe Leu Leu Ile S Asn 145 Phe Ser Lys Leu Lys 225 Leu Gly Ile Leu Ala Leu Leu Ile Ser Lys Glu Lys Thr Tyr Leu Lys Arg Phe Asp Tyr Ala 130 Asn Leu Lys Asp Leu 210 Leu Gly Leu Tyr His Gly Leu Pro Thr Tyr 115 Ile Gin Val Glu Thr 195 Pro Glu Leu Arg Leu Phe Leu Asn Ser Thr 100 Ala Ser Gin Gly Ile 180 Leu Phe Gin Ala 5 Ser Tyr Leu Arg Val 85 Ile Asn Thr Asp Val 165 Thr Ile Gly Lys Tyr Pro Gly Ala 70 Leu Ala Arg Ala Leu 150 Leu Glu Thr Leu Lys 230 Gly Leu Phe 55 Lys Gly Ser Val Leu 135 Ile Leu Leu Ser Thr 215 Ala Val Val 40 Lys Lys Asn Phe Phe 120 Phe Leu Leu Leu Gin 200 Lys Ala Leu 25 Lys Thr Asp Ser Leu 105 Gin Pro Gin Cys Phe 185 Val Leu Lys 10 Leu Leu Lys Leu Ser 90 Ala Leu Ser Arg Ser 170 Glu Phe Phe Ile Gly Gly Asn Lys 75 Ala Ser Pro Ile Leu 155 Ile Arg Ser Ser Ser 235 Gly Leu Thr Ala Gin Gly Leu Ala 140 Gin Gly Gly Leu Leu 220 Leu His Val Trp Asn Phe Ile Ser Ala 125 Ile Lys Gly Gin Tyr 205 Trp Ile Lau Ala Asp Lys Phe Ala Val 110 Leu Ala Ala Ile Phe 190 Leu Leu Ser Glu Gin Leu Lys Lys Ser Ser Phe Leu Trp Met 175 Ser Leu Tyr Leu Ala Ile Leu Glu Gin Phe Tyr Ala Lys Phe 160 Leu Pro Gly Ala Phe 240 Ala Ser Leu Ser Leu Met Pro Leu Leu Gly Val Leu 245 250 255 INFORMATION FOR SEQ ID NO:487: SEQUENCE CHARACTERISTICS: LENGTH: 16 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...16 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:487 Leu Leu Leu Met Leu Asn Lys Pro Lys Pro Leu Phe Leu Unk Leu Gly 1 5 10 INFORMATION FOR SEQ ID NO:487: SEQUENCE CHARACTERISTICS: LENGTH: 16 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES S (vi) ORIGINAL SOURCE: S* ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...16 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:487 Leu Leu Leu Met Leu Asn Lys Pro Lys Pro Leu Phe Leu Unk Leu Gly 1 5 10 INFORMATION FOR SEQ ID NO:488: SEQUENCE CHARACTERISTICS: LENGTH: 77 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...77 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:488 Val Leu Lys Tyr Pro Thr Met Phe Met Cys Ala Asp Ala Val Ile Ile 1 5 10 Ser Lys Ala Asp Met Ile Glu Val Phe Asn Phe Arg Val Ser Gin Val 2S Lys Giu Asp Met Gin Lys Leu Lys Pro Giu Ala Pro Ile Phe Leu Met 40 Ser Ser Lys Asp Pro Lys Ser Leu Giu Asp Phe Lys Asn Phe Leu Leu 55 Glu Lys Lys Arg Giu Asn Tyr Gin Ser Thr His Ser Phe 70 INFORM4ATION FOR SEQ ID NO:489: SEQUENCE CHARACTERISTICS: LENGTH: 180 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helijobacter pylori (ix) FEATURE: NAME/ KEY misc-feature LOCATION .180 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:489 Met Leu Leu Cys Ala Gly Arg Asn Giu Thr Leu Lys Lys Ala Val Pro 1 5 10 Ile Gly Val Gly Leu Ile Giu Ser Ala Ile Asn Leu Thr Arg Met Cys 25 Leu Lys Asn Pro Asp Thr Giu Ser Leu Ile Phe Ile Gly Ser Ala Gly 40 Ser Tyr Ser Pro Giu Thr Giu Ile Leu Ser Val Phe Giu Ser Ile Giu 55 Gly Tyr Gin Ile Glu Giu Ser Phe Ser His Leu Asn Ser Tyr Thr Pro 70 75 *Leu Asp Asn Phe Ile His Ile Giu Thr Lys Glu Gin Ala Leu Phe Glu r alAgVa s 8 r5r s y 90 Arg al xg al sn er er s yr le His Thr Ser Giu Met Phe 100 105 110 Ala Lys Lys Met Val Gin Lys Gly Val Leu Leu Giu Asn Met Glu Phe 115 120 125 Phe Ser Val Leu Ser Val Ala Lys Ile Phe Ser Leu Lys Ala Lys Gly 130 135 140 Ile Phe Cys Val Ser Asn His Val Gly Leu Asn Ala His Lys Giu Phe *145 Gu150 155 160 Lys GuAsn His Ala Lys Val Lys Gin Ile Leu Glu Asn Ile Ile Asp 165 170 175 Ser Leu Ile Val 180 INFORMATION FOR SEQ ID NO:490: SEQUENCE CHARACTERISTICS: LENGTH: 213 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...213 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:490 Val Tyr Glu Glu Arg Ile Thr Leu Ala Ser Gin Gly Ile Pro Lys Thr 1 5 10 Ser Lys Val Gly Phe Glu Ile Phe Asp Thr Lys Asp Phe Gly Ala Thr 25 Asp Phe Asp Gin Asn Ile Lys Leu Ile Arg Ala Ile Glu Gly Glu Leu 40 Ser Arg Thr Ile Glu Ser Leu Asn Pro Ile Leu Lys Ala Asn Val His 55 Ile Ala Ile Pro Lys Asp Ser Val Phe Val Ala Lys Glu Val Pro Pro 70 75 Ser Ala Ser Val Met Leu Lys Leu Lys Pro Asp Met Lys Leu Ser Pro 90 Thr Gin lie Leu Gly Ile Lys Asn Leu Ile Ala Ala Ala Val Pro Lys 100 105 110 Leu Thr Ile Glu Asn Val Lys Ile Val Asn Glu Asn Gly Glu Ser Ile 115 120 125 Gly Glu Gly Asp Ile Leu Glu Asn Ser Lys Glu Leu Ala Leu Glu Gin 130 135 140 Leu Arg Tyr Lys Gin Asn Phe Glu Asn Ile Leu Glu Asn Lys Ile Val 145 150 155 160 Asn Ile Leu Ala Pro Ile Val Gly Unk Lys Asn Unk Val Val Unk Unk 165 170 175 Val Asn Unk Glu Phe Unk Phe Unk Gin Lys Lys Ser Thr Lys Glu Thr P A 180 185 190 Phe Asp Pro Asn Asn Val Gly Lys Glu Arg Ala Lys Phe Arg Arg Lys :0 o, 195 200 205 Lys Arg Arg Arg Ser 210 *00. INFORMATION FOR SEQ ID NO:491: SEQUENCE CHARACTERISTICS: LENGTH: 148 amino acids TYPE: amino acid TOPOLOGY: linear o* (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...148 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:491 Val Ile Lys Lys Gly Tyr Ile Arg Gly Asp Leu Met Arg Ile Val Arg 1 5 10 Asn Leu Phe Leu Val Ser Phe Val Ala Tyr Ser Ser Ala Phe Ala Ala 25 Asp Leu Glu Thr Gly Thr Lys Asn Asp Lys Lys Ser Gly Lys Lys Phe
I
40 Tyr Lys Leu His Lys Asn His Gly Ser Glu Thr Glu Thr Lys Asn Asp 55 Lys Lys Leu Tyr Asp Phe Thr Lys Asn Ser Gly Leu Glu Gly Val Asp 70 75 Leu Glu Lys Ser Pro Asn Leu Lys Ser His Lys Lys Ser Asp Lys Lys 90 Phe Tyr Lys Gin Leu Ala Lys Asn Asn Ile Ala Glu Gly Val Ser Met 100 105 110 Pro Ile Val Asn Phe Asn Lys Ala Leu Ser Phe Gly Pro Tyr Phe Glu 115 120 125 Arg Thr Lys Ser Lys Lys Thr Gin Tyr Met Asp Gly Gly Leu Met Met 130 135 140 His Ile Arg Phe 145 INFORMATION FOR SEQ ID NO:492: SEQUENCE CHARACTERISTICS: LENGTH: 281 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...281 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:492 Val Met Ile Asp Pro Lys Met Val Glu Phe Ser Ile Tyr Ala Asp Ile 1 5 10 0* Pro His Leu Leu Thr Pro Ile Ile Thr Asp Pro Lys Lys Ala Ile Gly 20 25 Ala Leu Gin Ser Val Ala Lys Glu Met Glu Arg Arg Tyr Ser Leu Met 40 Ser Glu Tyr Lys Val Lys Thr Ile Asp Ser Tyr Asn Glu Gin Ala Gin 50 55 Ser Asn Asp Val Glu Ala Phe Pro Tyr Leu Ile Val Val Ile Asp Glu 70 75 Leu Ala Asp Leu Met Met Thr Gly Gly Lys Glu Ala Glu Phe Pro Ile 90 Ala Arg Ile Ala Gin Met Gly Arg Ala Ser Gly Leu His Leu Ile Val 100 105 110 Ala Thr Gin Arg Pro Ser Val Asp Val Val Thr Gly Leu Ile Lys Thr 115 120 125 Asn Leu Pro Ser Arg Val Ser Phe Arg Val Gly Thr Lys Ile Asp Ser 130 135 140 Lys Val Ile Leu Asp Thr Asp Gly Ala Gin Ser Leu Leu Gly Arg Gly 145 150 155 160 Asp Met Leu Phe Thr Pro Pro Gly Thr Asn Gly Leu Val Arg Leu His 165 170 175 Ala Pro Phe Ala Thr Glu Asp Glu Ile Lys Lys Ile Val Asp Phe Ile 180 185 190 Lys Ala Gin Lys Glu Val Glu Tyr Asp Lys Asp Phe Leu Leu Glu Glu 195 200 205 Ser Arg Met Pro Leu Asp Thr Pro Asn Tyr Gin Gly Asp Asp Ile Leu 210 215 220 410 Glu Arg Ala Lys Ala Val Ile Leu Glu Lys Lys Ile Thr Ser Thr Ser 225 230 235 240 Phe Leu Gin Arg Gin Leu Lys Ile Gly Tyr Asn Gin Ala Ala Thr Ile 245 250 255 Thr Asp Glu Leu Glu Ala Gin Gly Phe Leu Ser Pro Arg Asn Ala Lys 260 265 270 Gly Asn Arg Glu Ile Leu Gin Asn Phe 275 280 INFORMATION FOR SEQ ID NO:493: SEQUENCE CHARACTERISTICS: LENGTH: 144 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...144 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:493 Met Asn Phe Phe Lys Ile Leu Leu Met Glu Leu Arg Ala Ile Val Ser 1 5 10 His Lys Gly Val Leu Leu Ile Leu Ile Gly Ala Pro Leu Ile Tyr Gly 25 Leu Leu Tyr Pro Leu Pro Tyr Leu Lys Asp Ile Val Thr Gin Gin Lys 35 40 SIle Ala Leu Val Asp Glu Asp Asn Ser Phe Leu Ser Arg Gin Leu Ala 55 Phe Met Val Gin Ser Ser Asn Glu Leu Glu Ile Ala Phe Phe Ser Pro 65 70 75 Ser Met Leu Glu Ala Lys Lys Leu Leu Lys Glu Glu Lys Ile Tyr Gly 85 90 Ile Leu His Ile Pro Ser His Phe Glu Ala Asn Ile Tyr Lys Gin Ser 100 105 110 Ala Cys Asn Asp Arg Phe Leu Cys Glu Arg Gin Leu Leu Phe Asp Leu 115 120 125 Trp Cys Val Ser Glu Cys Gly Gly Gly Glu His Gin Arg Leu Lys Arg 130 135 140 INFORMATION FOR SEQ ID NO:494: SEQUENCE CHARACTERISTICS: LENGTH: 73 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...73 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:494 Val Gly Gly Leu Ala Met Leu Gly Phe Phe Tyr Asn Ile Glu Lys Ile 1 5 10 Ser Leu Ala Thr Ala Thr Ala Phe Ser Gin Cys Ala Pro Unk Tyr Thr 25 Val Leu Leu Ser Pro Leu Leu Leu Lys Glu Lys Leu Lys Arg Ser Ala 40 Leu Ile Ser Ala Cys Ile Gly Leu Val Gly Val Val Leu Ile Ser Asp 55 Pro Ser Val Glu Asn Val Gly Pro Ser INFORMATION FOR SEQ ID NO:495: SEQUENCE CHARACTERISTICS: LENGTH: 311 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori to (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...311 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:495 Val Cys Trp Thr Asp Leu Ile Gin Gly Leu Leu Met Met Ser Ala Leu 1 5 10 Ile Val Val Pro Ile Val Met Ile Ile His Leu'Gly Gly Ile Gly Glu 20 25 S* Gly Ile Lys Ile Ile Arg Glu Ile Lys Pro Glu Asn Leu Ser Phe Unk 40 Gin Gly Ser Ser Val Val Ala Ile Ile Ser Ser Leu Ala Trp Gly Leu 50 55 Gly Tyr Phe Gly Gin Pro His Ile Leu Val Arg Phe Met Ser Ile Arg 65 70 75 Ser Ile Arg Asp Val Pro Lys Ala Thr Thr Ile Gly Ile Ser Trp Met 85 90 t Val Ile Ser Leu Ile Gly Ala Cys Val Met Gly Leu Leu Gly Val Ala 100 105 110 Tyr Val His Lys Unk Asp Leu Ser Leu Glu Asp Pro Glu Lys Ile Phe 115 120 125 Ile Val Met Ser Gin Leu Leu Phe Asn Pro Trp Ile Thr Gly Ile Leu 130 135 140 Leu Ser Ala Ile Leu Ala Ala Val Met Ser Thr Ala Ser Ser Gin Leu 145 150 155 160 Leu Val Ser Ser Ser Thr Ile Ala Glu Asp Phe Tyr Ala Thr Ile Phe 165 170 175 Asn Lys Asn Ala Pro Gin Lys Leu Val Met Thr Ile Ser Arg Leu Ser 180 185 190 Val Leu Gly Val Ala Cys Ile Ala Phe Phe Ile Ser Thr Asp Lys Asn 195 200 205 Ala Ser Ile Leu Ser Ile Val Ser Tyr Ala Trp Ala Gly Phe Gly Ala 210 215 I
I
412 Ser Phe Gly Ser Val Ile Leu Phe Ser Leu Phe Trp Ser Arg Met Thr 225 230 235 240 Arg Ile Gly Ala Ile Ala Gly Met Leu Ser Gly Ala Ser Thr Val Ile 245 250 255 Leu Tyr Asp Lys Phe Gly Lys Ser Phe Leu Asp Ile Tyr Glu Ile Val 260 265 270 Pro Gly Phe Ile Val Ala Ser Val Ala Ile Val Ala Phe Ser Leu Phe 275 280 285 Ser Ser Val Arg Ser Gly Thr Lys Glu Ala Phe Glu Thr Met Leu Lys 290 295 300 Glu Ile Glu Ser Leu Lys His 305 310 INFORMATION FOR SEQ ID NO:496: SEQUENCE CHARACTERISTICS: LENGTH: 115 amino acids TYPE: amino acid TOPOLOGY: linear *o (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...115 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:496 Val Gly Leu Phe Ile Val Leu Phe Leu Ile Ile Met Lys His Gin Thr 1 5 10 Ser Pro Tyr Ala Phe Thr His Asn Gin Ala Leu Val Thr Gin Thr Pro 25 Pro Tyr Phe Thr Gin Leu Thr Ile Pro Lys Pro.Asn Asp Ala Leu Ser 40 Ala His Ala Ser Ser Leu Ile Ser Leu Pro Asn Asp Asn Leu Leu Ser 50 55 Ala Tyr Phe Ser Gly Thr Lys Glu Gly Ala Arg Asp Val Lys Ile Ser 70 75 Ala Asn Leu Phe Asp Ser Lys Thr Asn Arg Trp Ser Glu Ala Phe Ile 90 Leu Leu Thr Lys Glu Glu Leu Ser His His Ser His Glu Tyr Ile Lys 100 105 110 Lys Ile Arg 115 INFORMATION FOR SEQ ID NO:497: SEQUENCE CHARACTERISTICS: LENGTH: 200 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...200 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:497 Met Leu Val Gly Pro Thr Gly Val Gly Lys Thr Thr Thr Leu Ala Lys 1 5 10 Leu Ala Ala Arg Tyr Ser Arg Met Leu Ala Lys Lys Tyr Lys Val Gly 25 Ile Ile Thr Leu Asp Asn Tyr Arg Ile Gly Ala Leu Glu Gin Leu Ser 40 Trp Tyr Ala Asn Lys Met Lys Met Ser Ile Glu Ala Val Ile Asp Ala 55 Lys Asp Phe Ala Lys Glu Ile Glu Ala Leu Glu Tyr Cys Asp Phe Ile 70 75 Leu Val Asp Thr Thr Gly His Ser Gin Tyr Asp Lys Glu Lys Ile Ala 90 Gly Leu Lys Glu Phe Ile Asp Gly Gly Tyr Asn Ile Asp Val Ser Leu 100 105 110 Val Leu Ser Val Thr Thr Lys Tyr Glu Asp Met Lys Asp Ile Tyr Asp 115 120 125 Ser Phe Gly Val Leu Gly Ile Asp Thr Leu Ile Phe Thr Lys Leu Asp S130 135 140 Glu Ser Arg Gly Leu Gly Asn Leu Phe Ser Leu Val His Glu Ser Gin 145 150 155 160 :Lys Pro Ile Ser Tyr Leu Ser Val Gly Gin Glu Val Pro Met Asp Leu .165 170 175 Lys Val Ala Thr Asn Glu Tyr Leu Val Asp Cys Met Leu Asp Gly Phe 180 185 190 Ser Asn Pro Asn Lys Glu Gin Ala 195 200 INFORMATION FOR SEQ ID NO:498: SEQUENCE CHARACTERISTICS: LENGTH: 264 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...264 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:498 Val Gly Gly Ala Ser Phe Ile Ser Gly Gly Asn Gly Thr Leu Tyr Gly 1 5 10 Leu Asn Val Gly Tyr Asp Arg Leu Val Lys Ser Val Ile Leu Gly Gly 25 Tyr Val Ala Tyr Gly Tyr Ser Gly Phe Asn Gly Asn Ile Met His Ser 40 Leu Ala Asn Asn Val Asp Val Gly Met Tyr Ala Arg Ala Phe Leu Lys 55 Arg Asn Glu Phe Thr Leu Ser Ala Asn Glu Thr Tyr Gly Gly Asn Ala 70 75 Ser His Ile Asn Ser Ser Asn Ser Leu Leu Ser Val Leu Asri Gin Arg Tyr Asp Leu Asn 145 Ser Lys Ile Leu Thr 225 Val Asn Asn 100 Phe His Tyr Thr Tyr 180 Lys Arg Giu Lys Met 260 Asn Pro 125 C ly Pro Lys Arg Gly 205 Ala Val Asn Tyr 110 Gin Lys Ser Tyr Asp 190 Glu Ser As n Ile Gly Val1 Met Asn Phe 175 Leu Asn Val Ala Thr 255 INFORMATION FOR SEQ ID NO:499: SEQUENCE CHARACTERISTICS: LENGTH: 339 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .339 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:499 1Met Asp Gly Tyr Gly Phe Lys Met Gin Asp Leu Val Ile Lys Glu Gly Ile Asp Phe Gin Lys Thr Arg Lys Glu Gly Asp 130 Tyr Asp His Glu Thr Leu Glu Asn 100
LYS
Leu Asn
S
Ile Cys Ile Ala Asn Tyr Ala Val Ser 10 Asp Thr Cys Lys Ser 90 Leu
LYS
Asn Asn Gly Ser Ala Leu His Leu Ala Ala Leu 140 Leu Gin Ala Met Giu Ala Val Sen Leu 125 Glu Lys Thr 1s Glu Pro His Ile Lys Gly Ser Gin Tyr Gin Val Lys Lys Ang Asn Phe Ser Val1 Asn 145 150 155 160 Thr His Phe Leu Gly Val Leu Lys Asp Asp Lys Asn Leu Gin Leu Lys 165 170 175 Ile Leu Glu Leu Gin Gly Tyr Asp Val Ile Leu Ser Ser Ala Gly Val 180 185 190 Ser Val Gly Asp Lys Asp Phe Phe Lys Asp Ala Leu Lys Glu Arg Asn 195 200 205 Ala Leu Phe Tyr Tyr Glu Lys Val Asn Leu Lys Pro Gly Lys Pro Val 210 215 220 Thr Leu Ala Gin Leu Asn Gin Ser Ile Ile Ile Gly Leu Pro Gly Asn 225 230 235 240 Pro Leu Ser Cys Leu Leu Val Leu Arg Val Leu Ile Leu Pro Leu Leu 245 250 255 Glu Arg Leu Ser Leu Asn Lys Asp Phe Lys Leu Lys Pro Phe Lys Ala 260 265 270 Gin Ile Asn Ala Pro Leu Lys Leu Asn Asn Lys Arg Thr His Leu Ile 275 280 285 Leu Gly Asn Tyr Ser Asn His Gin Phe Ile Pro Tyr Asn Asn Arg Tyr 290 295 300 Glu Ser Gly Ala Ile Gin Ala Leu Ala Gin Val Asp Ser Ile Thr Leu 305 310 315 320 Ile Asp Glu Gly Val Gly Leu Val Gin Gly Glu Ile Glu Ile Leu Arg 325 330 335 Phe Glu Asn INFORMATION FOR SEQ ID NO:500: SEQUENCE CHARACTERISTICS: LENGTH: 146 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...146 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:500 Met Pro Tyr Ala Leu Arg Lys Arg Phe Phe Lys Arg Leu Leu Leu Phe 1 5 10 Phe Leu Ile Val Cys Met Ile Asn Leu His Ala Lys Ser Tyr Leu Phe 25 Ser Pro Leu Pro Pro Ala His Gin Gin Ile Ile Lys Thr Glu Pro Cys 40 Ser Leu Glu Cys Leu Lys Asp Leu Met Leu Gin Asn Gin Ile Phe Ser 55 Phe Val Ser Gin Tyr Asp Asp Asn Asn Gin Asp Glu Ser Leu Lys Thr 70 75 Tyr Tyr Lys Asp Ile Leu Asn Lys Leu Asn Pro Val Phe Ile Ala Ser 90 Gin Thr Pro Ala Lys Glu Ser Tyr Glu Pro Lys Ile Glu Leu Ala Ile 100 105 110 Leu Leu Pro Lys Lys Val Val Gly Arg Tyr Ala Ile Leu Val Met Asn 115 120 125 Thr Leu Leu Ala Tyr Phe Glu His Gin Lys Gin Arg Phe Gin Tyr Pro 130 135 140 Ser Leu 145 INFORMATION FOR SEQ ID NO:501: SEQUENCE CHARACTERISTICS: LENGTH: 60 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...60 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:501 Met Pro Ile Asn Pro Leu Tyr Leu Phe Pro Asn Leu Phe Thr Ala Ser 1 5 10 Ser Ile Phe Leu Gly Met Met Ser Ile Phe Tyr Ala Ser Ser Tyr Gin 25 Phe Val Met Ala Cys Trp Leu Val Val Ala Ser Leu Ile Leu Asp Gly 40 Leu Asp Gly Arg Val Ala Arg Leu Thr Lys His His 55 0* 9* 9 .99 INFORMATION FOR SEQ ID NO:502: SEQUENCE CHARACTERISTICS: LENGTH: 350 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...350 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:502 Met Ala Leu Arg Val Leu Leu Phe Phe Cys Phe 1 5 10 Glu Asp Lys Ser Gin Glu Leu Ser Ser Ile Gin 25 Val Asp Lys Lys Leu Ala Lys Asp Asp Asn Val 40 Glu Asn Tyr Lys Ile Tyr Asn Gin Ile Tyr Thr i Arg Gin Glu Leu Arg Arg Leu Lys Asn Lys Lys 70 75 Lys Ile Ser Thr Leu Glu His Thr Leu Lys Ala Phe Leu Gin Ala Gin Met Ala Leu Leu Lys Lys Phe Lys Glu Ser Val Lys Asp Leu Leu Glu Ser Gin Gin Ile Giu Lys Arg Ile Leu 145 Gin Lys Gin Asp Leu 225 Phe Giu Val Leu Lys 305 Gly Ile Met Phe Giu Ser Tyr Gly Val Asn Pro Phe Lys Asp Leu Pro Asp 130
LYS
LYS
Leu Gly Ser 210 Phe Ala Arg Ile Val 290 Asp Ser Phe Asn 115 Gly Asn His Ser Ala 195 Asp Lys Trp Val Unk 275 Thr Leu Val Ile 100 Ile Ile As n Gin Asp 180 Gin Glu Leu Ile 260 Unk ValI Phe His Gly 340 110 Pro Ser Gin Leu 165 Giu Asn Ala Val Leu 245 Thr Ile Leu Met Vali 325 Asp Asn Phe Thr 150 Leu Ile Ile Ile Tyr 230 Lys Val1 Unk G ly Ser 310 G iy Val Ile Ile 135 Ser Asn Tyr Leu Ser 215 Val1 Ile Asn Leu Phe 295 Leu Asp Leu Pro 120 Lys Leu Gin Gin Lys 200 Ile Phe Ile Lys Phe 280 Ala Leu Arg Asp Asn Ser Gly Trp Thr Thr Val Leu Ser Ala 265 Ser Ser G iy Val Thr 345 Ile Met G iu His 170 Gin Thr Lys Ala Ser 250 Ile Tyr Aia Trp Arg 330 Ser Ala Arg Val1 155 Ala Ala Ile Ser Ala 235 Lys Asn Leu Gly Phe 315 Ile Asn Asn Leu 140 Lau Lau Lys Gly Gin 220 Leu Tyr Phe Giu Leu 300 Ile Aia Val1 Pro 125 Lys Lys Asp Arg Ile 205 Val Leu Ile Val Asn 285 Ala Ile Lys Val Ile His Leu Lys Lau 190 Phe Lys Ser Giu Asn 270 Vali Ile Lau Giy His 350 Aia G iu Leu Ser 175 Giu Gin Asn Val1 Asn 255 Val Thr Unk Ile Thr 335 Ile Asn Asp 160 Ala Leu Lys Gin Val.
240 Asn Ser Ty~r Met Giy 320 Asp t5~ .n.
eq
S
S. S
S
5 5 .61.
so, 6 INFORMATION FOR SEQ ID NO:502: SEQUENCE CHARACTERISTICS: LENGTH: 350 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/ KEY misc..featune LOCATION 350 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:502 Met Ala Leu Ang Vai Leu Leu Phe Phe Cys Phe Leu Phe Leu Gin Aia 1 5 10 is Glu Asp Lys Ser Gin Glu Leu Ser Sen Ile Gin Lys Gin Met Ala Leu 25 Val Asp Lys Lys Leu Ala Lys Asp Asp Asn Val Trp Leu Lys Lys Phe 40 Giu Asn Tyr Lys Ile Tyr Asn Gin Ile Tyr Thr Giu Lys Giu Sen Val 55 Arg Gin Giu Leu Arg Ang Leu Lys Asn Lys Lys Sen Lys Asp Leu, Leu .70 75 Lys Ile Ser Thr Leu Glu His Thr Leu Lys .Arg Ile Leu 145 Gin
LYS
Gin Asp Leu 225 Phe Glu Val Leu
LYS
305 Gly Ile Met Pro Asp 130 Lys
LYS
Leu Gly Ser 210 Phe Ala Arg Ile Val 290 Asp Ser Phe Phe Asn 115 Gly Asn His Ser Ala 195 Asp
LYS
Trp Val Unk 275 Thr Leu Val Ile Glu 100 Ile Ile Asn Gin Asp 180 Gin Giu Leu Ile Tyr 260 Unk Vai Phe His Gly 340 Tyr Asn Phe Thr I50 Leu Ile Ile Ile Tyr 230 Lys Val Unk Gly Ser 310 Gly Val Gly Ile Ile 135 Ser Asn Tyr Leu Ser 215 Val1 Ile Asn Leu Phe 295 Leu Asp Leu As n 105 Asn Ser Gly Trp Thr 185 Thr Val1 Leu Ser Ala 265 Ser Ser Gly Val1 Thr 345 Lys Pro Ile Met Giu His 170 Gin Thr Lys Ala Ser 250 Ile Ala Trp Arg 330 Ser Ala Leu Giu Ser Phe Ala Arg Val1 155 Ala Ala Ile Ser Ala 235 Lys As n Leu Gly Phe 315 Ile Asn Lys Asn Leu 140 Leu Leu Lys Gly Gin 220 Leu Tyr Phe Glu Leu 300 Ile Ala Val Asp Pro 125 Lys Lys Asp Arg Ile 205 Val1 Leu Ile Val Asn 285 Aia Ile Lys Val Leu 110 Ile His Leu Lys Leu 190 Phe Lys Ser Giu Asn 270 Val1 Ile Leu Gly His 350 Gin Ile Ala Glu Leu Ser 175 Giu Gin Asn Val1 Asn 255 Val1 Thr Unk Ile Thr 335 INFORMATION FOR SEQ ID NO:503: SEQUENCE CHARACTERISTICS: LENGTH: 233 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1.7.233 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:503 Leu Ser Ala Leu Leu Ser Lys Met Gly Thr 5 10 Leu Leu Pro Leu Phe Pro Giu Leu Sen Giu 25 Ala Ile Vai Ala Leu Cys Met Ile Ile Tyr 40 Ala Gin Lys Asp Leu Lys Thr Leu Ile Ala Met Gly Val Val Val Leu Gly Val Phe Ser Met
I
Phe Ile Tyr His T'yr Ala Leu Leu Ang Ile Tyr Lou Thr Pro Gly Gly Phe Leu Ala Tyr Sen Sen Phe Sen Phe Asn Val Glu Gly 70 75 Val Ser Gly Ala Val Phe Met Met Phe Ala His Gly Val Ile Val Met 90 Gly Leu Phe Leu Leu Ala Gly Ile Leu Glu Glu Arg Ala Ser Ser Leu 100 105 110 Glu Ile Ala Arg Phe Gly Ser Ile Ala Lys Ser Ala Pro Val Phe Ala 115 120 125 Ala Phe Phe Met Ile Val Leu Met Ala Asn Val Gly Met Pro Leu Ser 130 135 140 Ile Gly Phe Val Gly Glu Phe Leu Asn Leu Leu Gly Phe Phe Ala Thr 145 150 155 160 Tyr Pro Leu Leu Ala Ile Ile Ala Gly Thr Ser Leu Ile Leu Ser Ala 165 170 175 Val Tyr Ile Leu Thr.Ser Tyr Lys Asp Val Phe Phe Gly Asn Leu Lys 180 185 190 Thr Gly Asn Asn Gin Ile Ser Val Phe Glu Asp Leu Asn Ala Arg Glu 195 200 205 Val Gly Val Leu Ser Val Ile Leu Ala Phe Asp Leu Asn Phe Arg Asp 210 215 220 Leu Tyr Lys Ser Ala Phe Lys Thr Asp 225 230 INFORMATION FOR SEQ ID NO:504: SEQUENCE CHARACTERISTICS: LENGTH: 32 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...32 xi) SEQUENCE DESCRIPTION: SEQ ID NO:504 Val Glu Leu Ile Ser Asn Asn Pro Asn Ala Ser Gin Gin Ser Ile Val 1 5 10 Ile Pro Leu Glu Thr Phe Ala Leu Ala Arg Ala Leu Lys Gly Ile Phe 25 INFORMATION FOR SEQ ID NO:505: SEQUENCE CHARACTERISTICS: LENGTH: 171 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature 420 LOCATION 1...171 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:505 Met Lys Ile Phe Gly Thr Asp Gly Val Arg Gly Lys Ala Gly Val Lys 1 5 10 Leu Thr Pro Met Phe Val Met Arg Leu Gly Ile Ala Ala Gly Leu Tyr 25 Phe Lys Lys His Ser Gin Thr Asn Lys Ile Leu Ile Gly Lys Asp Thr 40 Arg Lys Ser Gly Tyr Met Val Glu Asn Ala Leu Val Ser Ala Leu Thr 55 Ser Ile Gly Tyr Asn Val Ile Gin Ile Gly Pro Met Pro Thr Pro Ala 70 75 Ile Ala Phe Leu Thr Glu Asp Met Arg Cys Asp Ala Gly Ile Met Ile 90 Ser Ala Ser His Asn Pro Phe Glu Asp Asn Gly Ile Lys Phe Phe Asn 100 105 110 Ser Tyr Gly Tyr Lys Leu Lys Glu Glu Glu Glu Arg Ala Ile Glu Glu 115 120 125 Ile Phe His Asp Glu Glu Leu Leu His Ser Ser Tyr Lys Val Gly Glu 130 135 140 Ser Val Gly Ser Ala Lys Arg Ile Asp Asp Val Ile Gly Pro Leu Tyr 145 150 155 160 S Arg Ala Phe Glu Ala Leu Tyr Thr Gin Thr Phe 165 170 S(2) INFORMATION FOR SEQ ID NO:506: SEQUENCE CHARACTERISTICS: S: LENGTH: 33 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...33 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:506 Val Arg Ala Val Phe Val Phe Gly Leu Lys Ala Ala Phe Cys Ile Gly 1 5 10 Ile Phe Phe Tyr Gly Ala Tyr Tyr Phe Leu Asp Glu Phe Leu Ile Lys 25 Leu INFORMATION FOR SEQ ID NO:507: SEQUENCE CHARACTERISTICS: LENGTH: 99 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...99 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:507 Met Lys Glu Gin Glu Trp Asp Leu Ser Ala Leu Phe Glu Asn Lys Glu 1 5 10 Ser Ala Glu Glu Phe Leu Lys Thr Leu Gin Thr Glu Val Gln Glu Phe 25 Glu Asn Ala Tyr Gin Asn Asn Leu Lys Asn Leu Asp Ala Ala Lys Phe 40 Ala Asn Thr Leu Lys His Tyr Glu Asn Leu Ser Glu Lys Ile Ser Arg 55 Ala Met Ala Tyr Ala Asn Tyr Phe Leu Pro Arg Thr Leu Lys Lys Arg 70 75 Ser Phe Ile Arg Asn Ala Asn Gly Leu Cys Lys Tyr Pro Thr Thr Pro 90 Phe Ile Leu INFORMATION FOR SEQ ID NO:507:.
SEQUENCE CHARACTERISTICS: LENGTH: 99 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...99 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:507 Met Lys Glu Gin Glu Trp Asp Leu Ser Ala Leu Phe Glu Asn Lys Glu 1 5 10 Ser Ala Glu Glu Phe Leu Lys Thr Leu Gin Thr Glu Val Gin Glu Phe 25 Glu Asn Ala Tyr Gin Asn Asn Leu Lys Asn Leu Asp Ala Ala Lys Phe 40 Ala Asn Thr Leu Lys His Tyr Glu Asn Leu Ser Glu Lys Ile Ser Arg 55 Ala Met Ala Tyr Ala Asn Tyr Phe Leu Pro Arg Thr Leu Lys Lys Arg 70 75 Ser Phe Ile Arg Asn Ala Asn Gly Leu Cys Lys Tyr Pro Thr Thr Pro 90 Phe Ile Leu INFORMATION FOR SEQ ID NO:508: 422 SEQUENCE CHARACTERISTICS: LENGTH: 78 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...78 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:508 1 Arg Val Gly Met Tyr Glu Val Cys Asn His 5 10 r His Ser Thr Arg Gly Ser Lys Val Thr Leu 25 r Ala Gin Val Val Glu Ile Ala Gin Asn Ile 40 i Lys Asp Met Glu Tyr Phe His Unk Ser His 55 r Leu Unk Pro Met Lys Asn Pro Asn Thr Leu 70 Leu 1 Ty3 Th3 Gl Ty 65
L
A
U
6
S
r r r r r INFORMATION FOR SEQ ID NO:508: SEQUENCE CHARACTERISTICS: LENGTH: 78 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...78 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:508 Leu Arg Val Gly Met Tyr Glu Val Cys Asn His 1 5 10 Tyr His Ser Thr Arg Gly Ser Lys Val Thr Leu 25 Thr Ala Gin Val Val Glu Ile Ala Gin Asn Ile 40 Glu Lys Asp Met Glu Tyr Phe His Unk Ser His 55 Tyr Leu Unk Pro Met Lys Asn Pro Asn Thr Leu 70 ys Asp Gly Thr Ala .la Cys Lys Thr Gly al Asn Arg Met Lys nk Trp Ile Thr Unk 0 er Leu Phe Lys Asp Gly Thr Ala Ala Cys Lys Thr Gly Val Asn Arg Met Lys Unk Trp Ile Thr Unk Ser Leu Phe INFORMATION FOR SEQ ID NO:509: SEQUENCE CHARACTERISTICS: LENGTH: 70 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...70 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:509 Val Arg Ser Gly Lys Arg Leu Gly Tyr Thr Asn Gin Val Ile Thr Asp 1 5 10 Ile Val Asn Ile Gly Ile Gly Gly Ser Asp Leu Gly Ala Leu Met Val 25 Cys Thr Ala Leu Lys Arg Tyr Gly His Pro Arg Leu Lys Met His Phe 40 Val Ser Asn Val Glu Trp His Ala Asp Phe Arg Arg Phe Gly Lys Asn 50 55 Gin Pro Gly Gin Arg Ala INFORMATION FOR SEQ ID NO:510: SEQUENCE CHARACTERISTICS: LENGTH: 130 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...130 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:510 Met Asn Leu Val Phe Leu Trp Ala Ala Leu Gly Gly Ala Ile Gly Ser 1 5 10 Ser Leu Arg Tyr Phe Val Gly Lys Met Met Pro Ser Lys Phe Leu Met 25 Phe Glu Ser Phe Pro Leu Gly Thr Phe Ser Val Asn Leu Ile Gly Cys 40 Phe Ile Ile Gly Phe Met Gly His Leu Ala Ala Lys Lys Val Phe Gly 55 Asp Asp Phe Gly Ile Phe Phe Val Thr Gly Val Leu Gly Gly Phe Thr 70 75 Thr Phe Ser Ser Tyr Gly Leu Asp Thr Leu Lys Leu Leu Gin Lys Ser 90 Gin Tyr Leu Glu Ala Ile Ser Tyr Val Leu Gly Thr Asn Leu Leu Gly 100 105 110 Leu Ile Gly Val Ala Ile Gly Trp Phe Leu Ala Lys Asn Phe Val Gly 115 120 125 Val Asn 130 INFORMATION FOR SEQ ID NO:511: SEQUENCE CHARACTERISTICS: LENGTH: 52 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...52 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:511 Leu Gly Leu Val Unk Gly Ile Ser Leu Leu His Leu Ser Leu Glu Gin 5 10 Lys Ile Ser Val Phe Leu Gly Unk Asn Leu Met Leu Tyr Pro Val Unk 25 Glu Val Leu Phe Ser Ile Leu Arg Arg Lys Ile Lys Arg Gin Lys Ala 35 40 Thr His Ala Gly INFORMATION FOR SEQ ID NO:511: SEQUENCE CHARACTERISTICS: LENGTH: 52 amino acids TYPE: amino acid TOPOLOGY: linear e* (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
9** (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...52 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:511 Leu Gly Leu Val Unk Gly Ile Ser Leu Leu His Leu Ser Leu Glu Gin 1 5 10 Lys Ile Ser Val Phe Leu Gly Unk Asn Leu Met Leu Tyr Pro Val Unk 25 Glu Val Leu Phe Ser Ile Leu Arg Arg Lys Ile Lys Arg Gin Lys Ala 40 Thr His Ala Gly INFORMATION FOR SEQ ID NO:512: SEQUENCE CHARACTERISTICS: LENGTH: 79 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori r Met 1 Leu Tyr Ile Leu (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...79 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:512 Leu Glu Lys Leu Ile Glu Arg Val Leu Phe 5 10 Ala Pro Leu Cys Ile Ala Met Ser Leu Val 25 Val Phe Met Lys Glu Leu Trp His Met Leu 40 Ser Glu Thr Asp Leu Val Leu Ser Ala Leu 55 Val His Gly Arg Ala Cys Phe Asp Gly Ala 70 Ala Thr Arg Trp Leu Leu Val Val Leu Gly Ser His Leu Asn Thr Gly Leu Val Asp Leu Ala Arg Gin Leu
C.
C
C
INFORMATION FOR SEQ ID NO:513: SEQUENCE CHARACTERISTICS: LENGTH: 102 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...102 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:513 Met His Tyr Gin Leu Thr Ser Phe Asn Ile Ile 1 5 10 Thr Cys His Val Leu Arg Ile Lys Met Arg Val 25 Gly Val Phe Val Ser Asn Gly Leu Ala Arg Phe 40 Ile Pro Leu Leu Ile Leu Ser Gly Ser Leu Thr 55 Gin Leu Gly Ile Ala Val Leu Met Gly Tyr Val 70 75 Ile Gin Phe Leu Ser Pro Leu Met Ser Leu Lys 90 Ser Phe Lys Leu Thr Leu 100 Gin Phe Gly Pro Phe Ser Asp Val Tyr His Gly Ile Leu Phe Cys Phe Val Val Gin Ser Ser Phe Ala Lys Ile Leu Leu Phe Leu Ile INFORMATION FOR SEQ ID NO:514: SEQUENCE CHARACTERISTICS: LENGTH: 15 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc feature LOCATION 1...15 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:514 Val Asp Met Lys Asp Ala Val Gly Thr Tyr Lys Leu Unk Arg Ala 1 5 10 4 INFORMATION FOR SEQ ID NO:515: SEQUENCE CHARACTERISTICS: LENGTH: 377 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...377 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:515 Leu Ala Gln Pro Val Gln Val Arg Thr Val Phe Met Ser Met Thr Leu 1 5 10 Asn Ala Met Gly Gin Phe Ala Tyr Asn Phe Pro Ala Asn Ile Ser Lys 25 Asp Lys Gin Lys Leu Thr Met Val Tyr Met Asp Lys Asp Tyr Gly Ala 40 Tyr Gly Asn Ile Val Ala Met Gly Gly Glu Tyr Val Lys Ile Glu Leu 55 Gly Thr Asp Thr Gly Leu Asn Pro Phe Ala Trp Ala Ala Cys Val Gin 70 75 Lys Thr Asn Ala Thr Met Glu Gin Lys Gln Thr Ala Ile Ser Val Val 90 Lys Glu Leu Val Lys Asn Leu Ala Thr Lys Ser Asp Glu Lys Asp Glu 100 105 110 Asn Gly Asn Ser Ile Ser Phe Ser Leu Ala Asp Ser Asn Thr Leu Ala 115 120 125 Ala Ala Val Thr Asn Leu Ile Thr Gly Asp Met Asn Leu Asp Tyr Pro 130 135 140 Ile Thr Gln Leu Ile:Asn Ala Phe Gly Lys Asp His Asn Asp Pro Asn 145 150 155 160 Gly Leu Val Ala Arg Leu Ala Pro Phe Cys Lys Ser Thr Asn Gly Glu 165 170 175 Phe Gin Trp Leu Phe Asp Asn Lys Ala Thr Asp Arg Leu Asp Phe Ser 180 185 190 Lys Thr Ile Ile Gly Val Asp Gly Ser Ser Phe Leu Asp Asn Asn Asp 195 200 205 Val Ser Pro Phe Ile Cys Phe Tyr Leu Phe Ala Arg Ile Gin Glu Ala 210 215 220 Met Asp Gly Arg Arg Phe Val Leu Asp Ile Asp Glu Ala Trp Lys Tyr 225 230 235 240 Leu Gly Asp Pro Lys Val Ala Tyr Phe Val Arg Asp Met Leu Lys Thr 245 250 255 Ala Arg Lys Arg Asn Ala Ile Val Arg Leu Ala Thr Gin Ser Ile Thr 260 265 270 Asp Leu Leu Ala Cys Pro Ile Ala Asp Thr Ile Arg Glu Gin Cys Pro 275 280 285 Thr Lys Ile Phe Leu Arg Asn Asp Gly Gly Asn Leu Ser Asp Tyr Gin 290 295 300 Arg Leu Ala Asn Val Thr Glu Lys Glu Phe Glu Ile Ile Thr Lys Gly 305 310 315 320 Leu Asp Arg Lys Ile Leu Tyr Lys Gin Asp Gly Ser Pro Ser Val Ile 325 330 335 Ala Ser Phe Asn Leu Arg Gly Ile Pro Lys Glu Tyr Leu Lys Ile Leu ego* 340 345 350 S. Ser Thr Asp Thr Val Phe Val Lys Glu Ile Asp Lys Ile Ile Gin Asn 355 360 365 His Ser Ile Ile Asp Lys Tyr Gin Pro 370 375 *50.0 INFORMATION FOR SEQ ID NO:515: SEQUENCE CHARACTERISTICS: LENGTH: 377 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES
S
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...377 (xi) SEQUENCE DESCRIPTION: SEQ ID N0:515 Leu Ala Gin Pro Val Gin Val Arg Thr Val Phe Met Ser Met Thr Leu 1 5 10 Asn Ala Met Gly Gin Phe Ala Tyr Asn Phe Pro Ala Asn Ile Ser Lys 25 Asp Lys Gin Lys Leu Thr Met Val Tyr Met Asp Lys Asp Tyr Gly Ala 40 Tyr Gly Asn Ile Val Ala Met Gly Gly Glu Tyr Val Lys Ile Glu Leu 55 Gly Thr Asp Thr Gly Leu Asn Pro Phe Ala Trp Ala Ala Cys Val Gin 70 75 Lys Thr Asn Ala Thr Met Glu Gin Lys Gin Thr Ala Ile Ser Val Val 90 Lys Glu Leu Val Lys Asn Leu Ala Thr Lys Ser Asp Glu Lys Asp Glu 100 105 110 428 Asp Ser Asn Gly Asn Ser Ile Ser Phe Ser Leu Ala Asn Thr Leu Ala 115 120 Ala Ala 130 Ile Thr 145 Gly Leu Phe Gin Lys Thr Val Ser 210 Met Asp 225 Leu Gly Ala Arg Asp Leu Thr Lys 290 Arg Leu 305 Leu Asp Ala Ser Ser Thr His Ser 370 Val1 Gin Val Trp Ile 195 Pro Gly Asp Lys Leu 275 Ile Ala Arg Phe Asp 355 Ile Thr Leu Ala Leu 180 Ile Phe Arg Pro Arg 260 Ala Phe Asn Lys Asn 340 Thr Ile As n Ile Arg Phe Gly Ile Arg Lys 245 Asn Cys Leu Val1 Ile 325 Leu Val Asp Leu As n 150 Leu Asp Val1 Cys Phe 230 Val Ala Pro Arg Thr 310 Leu Arg Phe Lys Ile 135 Ala Ala Asnr Asp Phe 215 Val1 Ala Ile Ile Asn 295 Giu Tyr Gly Val1 Tyr 375 Thr Phe Pro Lys Gly 200 Tyr Leu Val1 Ala 280 Asp Lys Lys Ile Lys 360 Gin Gly Giy Phe Ala 185 Ser Leu Asp Phe Arg 265 Asp G ly Giu Gin Pro 345 Giu Pro Asp Met Lys Asp 155 Cys Lys 170 Thr Asp Ser Phe Phe Ala Ile Asp 235 Val Arg 250 Leu Ala Thr Ile Gly Asn Phe Giu 315 Asp dly 330 Lys Glu Ile Asp 125 Asn Leu 140 His Asn Ser Thr Arg Leu Leu Asp 205 Arg Ile 220 Glu Ala Asp Met Thr Gin Arg Giu 285 Leu Ser 300 Ile Ile Ser Pro Tyr Leu Lys Ile 365 Asp Asp Asn Asp 190 Asn Gin Trp Leu Se r 270 Gin Asp Thr Ser Lys 350 Ile Tyr Pro dly 175 Phe Asn Glu Lys Lys 255 Ile Cys Tyr Lys Val 335 Ile Gin Pro As n 160 Giu Ser "Asp Ala Tyr 240 Thr Thr Pro Gin G ly 320 Ile Leu Asn 000* 8* S S S S S. S 0S
OS..
.5 *5 S S
S
S .5 *555 S. S INFORMATION FOR SEQ ID NO:516:
S.
0 56* Ci) SEQUENCE CHARACTERISTICS: LENGTH: 1027 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .1027 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:516 Val Cys Leu Asp His Gin Val Gly Ala Gly Lys Thn Leu Cys Ala Ile 1 S 10 Ala Sen Cys Met Giu Gin Lys Arg Met Gly Leu Val Asn Lys Thr Leu 25 Ile Ala Val Pro Asn His Leu Thn Lys Gin Tnp Gly Asp Giu Phe Tyr 40 Lys Ala Tyn Pro Asn Ala Asn Val Leu Vai Val Asp Sen Lys Asp Thr 55 Thr Giu Lys Glu Arg Glu Leu Leu Phe Asn Gin Ile Ala Asn Asn Asn 6570 75 Tyr Asp Ala Val Val Ile Ala His Thr His Leu Giu Leu Leu Ser Asn 90 Pro Arg Gly Ile Ile Giu Giu Leu Lys Giu Giu Glu Leu Val Asn Ala 100 105 110 Giu Lys Asn Phe Giu Arg Gin Giu Leu Ala Tyr Lys Asn Asn Pro Arg 115 120 125 Giu Thr Lys Lys Pro Asn Glu Arg Ala Phe Lys Asn Lys Leu Asp Lys 130 135 140 Ile Arg Ala Lys Tyr Asp Ala Ile Leu Giu Lys Gin Giy Ser His Ile 145 150 155 160 Asp Ile Ser Gin Met Gly Ile Asp Asn Leu Ile Val Asp Giu Ala His 165 170 175 Leu Phe Lys Asn Leu Ala Phe Giu Thr Ser Met Glu Lys Ile Ala Gly 180 185 190 Leu Gly Asn Gin Gin Gly Ser Asn Arg Ala Arg Asp Leu Phe Ile Lys 195 200 205 Thr Arg Tyr Leu His Gin Asn Asp Lys Lys Ile Met Phe Leu Thr Giy 210 215 220 Thr Pro Ile Ala Asn Ser Leu Ser Giu Met Tyr His Leu Gin Arg Tyr 225 230 235 240 Leu Thr Pro Asp Val Leu Lys Giu Arg Giy Leu Giu Phe Phe Asp Asp 245 250 255 Trp Ala Lys Thr Tyr Gly Glu Val Vai Asn Asp Phe Giu Leu Asp Thr 260 265 270 Ser Ala Gin Ser Tyr Lys Met Val Asn Arg Phe Ser Lys Phe Ser Asp al 275 280 285 VlGin Gly Leu Ser Thr Met Tyr Arg Ala Phe Ala Asp Ile Val Ser *290 295 300 Asn Asp Asp Ile Leu Lys His Asn Pro His Phe Val Pro Lys Val Tyr 305 310 315 320 Gly Asp Lys Pro Ile Asn Val Val Val Lys Arg Ser Giu Giu Val Ala *325 330 335 Gin Phe Ile Gly Val Ala Leu Giu Asn Gly Lys Tyr Asn Giu Gly Ser 340 345 350 le Ile Asp Arg Met Gin Lys Cys Glu Gly Lys Lys Ser Gin Lys Gly GinAs 360 365 GnApAsn Ile Leu Ser Cys Thr Thr Asp Ala Arg Lys Val Ala Leu 370 375 380 Asp Tyr Arg Leu Ile Asp Pro Asn Ala Lys Val Giu Lys Glu Phe Ser 385 390 395 400 Lys Ser Tyr Ala Met Ala Lys Asn Ile Tyr Glu Asn Tyr Leu Glu Thr .99405 410 415 His Ala Thr Lys Gly Thr Gin Leu Gly Phe Ile Gly Leu Ser Thr Pro 420 425 430 Lys Thr His Ser Gin Lys Vai Ser Leu Giu Ala Leu Asp Asn Ala His 435 440 445 Glu Thr Giu Asn Lys Asn Pro Leu Asp Lys Ala Gin Giu Leu Leu Giu 450 455 460 Ser Leu Ser Ser Tyr Asp Giu Lys Gly Asn Leu Ile Ala Pro Ser Lys 465 470 475 480 Lys Glu Leu Giu Asn Giu Leu Lys Giu Lys Giu Ala Lys Ser Val Asn 485 490 495 Leu Asp Giu Glu Ile Ala Lys Gly Cys Ser Phe Asp Val Tyr Ser Asp 500 505 510 Val Leu Arg His Leu Vai Gin Met Gly Ile Pro Gin Asn Giu Ile Ala 515 520 525 Phe Ile His Asp Ala Lys Thr Giu Giu Gin Lys Gin Asp Leu Phe Lys 530 535 540 Lys Leu Asn Arg Giy Gly Val Arg Vai Leu Leu Gly Ser Pro Ala Lys 545 550 555 560 Met Gly Val Gly Thr Asn Val Gin Glu Arg Leu Val Ala Met His Giu 565 570 575 Leu Asp Cys Pro Trp Arg Pro Asp Giu Leu Leu Gin Met Giu Giy Arg 580 585 590 Gly Ile Arg Gin Gly Asn Ile Leu His Gin Asn Asp Pro Glu Asn Phe 595 600 605 Arg Met Lys Ile Tyr Arg Tyr Ala Thr Glu Lys Thr Tyr Asp Ser Arg 610 615 620 Met Trp Gin Ile Ile Glu Thr Lys Ser Lys Gly Ile Glu Gin Phe Arg 625 630 635 640 Asn Ala His Lys Leu Gly Leu Asn Glu Leu Glu Asp Phe Asn Met Gly 645 650 655 Ser Ser Asn Ala Ser Glu Met Lys Ala Glu Ala Thr Gly Asn Pro Leu 660 665 670 Ile Ile Glu Glu Val Lys Leu Arg Ala Glu Ile Lys Ser Glu Glu Ser 675 680 685 Lys Tyr Lys Ala Phe Asn Lys Glu His Tyr Phe Asn Glu Glu Ser Leu 690 695 700 Lys Asn Asn Ala Ser Lys Leu Asp Tyr Leu Lys Gin Glu Leu Lys Asp 705 710 715 720 Leu Glu Thr Leu Gin Arg Ser Val Ile Ile Pro Thr His Thr Glu Ile 725 730 735 Lys Leu Tyr Asp Leu Lys Asn Glu Glu Ser Lys Asp Tyr Glu Leu Ile 740 745 750 Lys Val Lys Glu Val Glu Pro Leu Lys Glu Asn Ala Ser Met Ser Glu 755 760 765 Glu Leu Thr His Lys Lys Leu Lys Glu Gin Asn Lys Gin Ile Ala Glu 770 775 780 Gn Asn Lys Glu Lys Leu Asp Ala Ile Lys Lys Gin Phe Ala Ser Asn 785 790 795 800 Leu Asn Thr Leu Phe Val Asn Glu G l u Glu Asp Tyr Lys Leu Leu Glu 805 810 815 Tyr Lys Gly Phe Val Val Asn Ala Tyr Lys Thr Lys Tyr Gin Val Glu 820 825 830 Phe Ser Leu Ser Pro Lys Asp Asn Pro Asn Ile Ala Tyr Ser Pro Ser 835 840 845 Asn Met Val Tyr Lys Asn Asp Thr Ile Asn Met Phe Ser Ser Tyr Asn 850 855 860 Phe Cys Ala Glu Ile Lys Phe Asp Gly Phe Leu Lys Arg Leu Asp Asn 865 870 875 880 Ala Ile Thr Lys Leu Pro Glu Lys Ile Lys Glu Leu Glu Asn Ser Ile 885 890 895 Glu Ile Thr Lys Lys Asn Ile Ala Lys Tyr Thr.Arg Leu Val Glu Gin 900 905 910 Lys Pro Ser Tyr Pro Arg Leu Glu Tyr Leu Gin Ala Leu Lys Trp Asp 915 920 925 His Lys Thr Leu Ile Asp Asp Leu Ala Lys Met Ser Lys Asp Arg Asn 930 935 940 Tyr Lys Pro Ala Phe Asn Pro Lys Ser Lys Glu Val Leu Lys Asn Leu 945 950 955 960 Asn Ala Glu Lys Arg Ala Ser Leu Glu Asn Glu Arg Glu Glu Gin Gly 965 970 975 Val Lys Gly Asn Thr Lys Ser His Asp Glu Ile Glu Pro Ala Thr Glu 980 985 990 Gin Val Ile Glu Lys Glu Ile Glu Lys Gly Asp Glu Ile Ala Asn Asn 995 1000 1005 Val Asp Tyr Tyr Glu Asn Glu Gin Glu Val Glu Ile Thr Lys Ser Met 1010 1015 1020 Gly Arg Arg 1025 INFORMATION FOR SEQ ID NO:517: SEQUENCE CHARACTERISTICS: LENGTH: 154 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .154 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:S17 Met Lys Leu Val Ser Leu Ile Val Ala Leu Val Phe Cys
I
Gly Met Ala Leu Phe
LYS
Gin Gly Ile 145 Ala Lys Tyr Asn Leu Ala Unk Tyr 130 Lys Val Ser Gly Pro Ser Unk Ser 115 Val Asn Glu Ser Ile Asn Asp Asn 100 Asn Gly Leu 5 Leu Phe Ser Pro Leu 85 Phe Gly Lys Lys Pro Val1 Asp Lys Ile Unk Asp Thr Leu 150 Gin Giu Ser Arg Glu Thr Thr Lys Asn Thr His Lys Ser Gin Unk Ser Arg Gin Asn Ala Asp Sen His Sen Leu 140 9* INFORMATION FOR SEQ ID NO:517: SEQUENCE CHARACTERISTICS: LENGTH: 154 amino acids TYPE: amino acid TOPOLOGY: linear iii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 154 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:517 Lys Leu Val Ser Leu Ile Val Ala Leu Val 5 10 Ala Val Glu Leu Pro Gly Val Tyr Gin Thr 25 Lys Ser Sen Phe Val Glu Phe Phe Glu His 40 Tyr Gly Ile Ser Asp Val Unk Unk Sen Lys 55 Asn Pro Asn Pro Lys Leu Arg Asn Arg Ser2 ,70 75 Met 1 Gly Met Ala Leu Phe Cys Cys Phe Leu is ;in Glu Phe Leu Tyr ksn Gly Lys Phe Tyr kla Lys Lys Asp Lys ksp Lys Gly Val Val 432 Phe Leu Ser Asp Leu Ile Lys Val Gly GlU Gin Ser Tyr Lys Gly Gly 90 Lys Ala Unk Asn Phe Unk Asp Gly Lys Thr Unk His Val Arg Val Thr 100 105 110 Gin Unk Ser Asn Gly Asp Leu Unk Phe Thr Ser Ser Tyr Unk Lys Trp 115 120 125 Gay Tyr Val Gly Lys Thr Phe Thr Trp Lys Arg Leu Ser Asp Glu Giu 130 135 140 Ile Lys Asn Leu Lys Leu Lys Arg Phe Asn 145 150 INFORMATION FOR SEQ ID NO:518: SEQUENCE CHARACTERISTICS: LENGTH: 62 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 62 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:518 M et Ala Glu Giu Glu Lys Thr Glu Leu Pro Sen Ala Lys Lys Ile Gin 1 5 10 Lys Ala Arg Glu Glu Gly Asn Val Pro Lys Sen Met Glu Val Val Gly 25 Val Phe Arg Val Ile Gly Trp Ala Asn Glu Tyr Phe Cys Phe Phe Tyr 40 Met Val Gly Gly Met Ala Leu Ala Ang Cys le. Ala Met Cys so 55 INFORMATION FOR SEQ ID NO:519: SEQUENCE CHARACTERISTICS: TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YZS (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION l. 237 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:S19 Met Lys Tbr Leu Val Lys Asn Thr Ile Tyr Sen Phe Leu Leu Leu Ser 1 5 10 Val Leu Met Ala Glu. Asp Ile Thr Ser Gly Leu Lys Gin Leu Asp Asn 25 Thr Tyr Gin Glu Thr Asn Gin Gin Val Leu Lys Asn Leu Asp Giu Ile 40 Phe Ser Thr Thr Ser Pro Ser Ala Asn Asn Lys Ile Gly Gin Giu Asp 55 Ala Leu Asn Ile Lys Lys Ala Ala Ile Ala Leu Arg Gly Asp Leu Ala 70 75 Leu Leu Lys Ala Asn Phe Giu Ala Asn Giu Leu Phe Phe Ile Ser Giu 90 Asp Val Ile Phe Lys Thr Tyr Met Ser Ser Pro Giu Leu Leu Leu Thr 100 105 110 Tyr Met Lys Ile Asn Pro Leu Asp Gin Lys Thr Ala Glu Gin Gin Cys 115 120 125 Gly Ile Ser Asp Lys Val Leu Val Leu Tyr Cys Giu Gly Lys Leu Lys 130 135 140 Ile Glu Gin Giu Lys Gin Asn Ile Arg Giu Arg Leu Giu Thr Ser Leu 145 I50 155 160 Lys Ala Tyr Gin Ser Asn Ile Gly Gly Thr Ala Ser Leu Ile Thr Ala 165 170 175 Ser Gin Thr Leu Val Giu Ser Leu Lys Asn Lys Asn Phe Ile Lys Gly 180 185 190 Ile Lys Lys Leu Met Leu Ala His Asn Lys Val Phe Leu Asn Tyr Leu 195 200 205 Glu Giu Leu Asp Ala Leu Giu Arg Ser Leu Giu Gin Ser Lys Arg Gin 210 215 220 Tyr Leu Gin Giu Arg Gin Ser Ser Lys Ile Ile Val Lys 225 230 235 INFORMATION FOR SEQ ID NO:520: SEQUENCE CHARACTERISTICS: LENGTH: 83 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .83 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:520 Val Ser Giu Lys Asp Arg Ala Phe Leu Leu Ala Ser Leu Ser Cys Val 1 5 10 Asp Tyr Val Val Val Phe Gly Glu Asp Thr Pro Ile Lys Leu Ile Gin 25 Ala Leu Lys Pro Asp Ile Leu Val Lys Gly Ala Asp TIyr Leu Asn Lys 40 Glu Val Ile Gly Ser Giu Leu Ala Lys Glu Thr Arg Leu Ile Glu Phe so 55 Glu Glu Gly Tyr Sen Thr Sen Ala Ile Ile Glu Lys Ile Lys Arg Thn 70 75 His Asn Asp INFORMATION FOR SEQ ID NO:52i: SEQUENCE CHARACTERISTICS: LENGTH: 7 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...7 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:521 Leu Glu Thr Leu Phe Leu Val 1 INFORMATION FOR SEQ ID NO:521: SEQUENCE CHARACTERISTICS: LENGTH: 7 amino acids TYPE: amino acid :o TOPOLOGY: linear (ii) MOLECULE TYPE: protein 999e '(iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori 9 9 (ix) FEATURE: NAME/KEY: misc_feature LOCATION I...7 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:521 0Leu Glu Thr Leu Phe Leu Val 1 INFORMATION FOR SEQ ID NO:522: SEQUENCE CHARACTERISTICS: LENGTH: 64 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION I...64 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:522 Tyr Asp Lys Ser Leu Cys Lys Thr Met Ala 10 Gly Val Lys Arg Ala Met Val Val Asn Gly 125 Val Leu His Asp Ile Thr His Ala Cys Glu 40 Leu Glu Tyr Asp Leu Ser Ala Lys Asp Phe so 55 Leu Ala Leu Lys Ala Gly Gly Thr Gly Glu Leu Lys Asn Asn Glu Asp Leu Pro Pro Ser INFORMATION FOR SEQ ID NO:523: Wi SEQUENCE CHARACTERISTICS: LENGTH: 228 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .228 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:523 0**9 4 9 *9*9 *9
B.
9*c9 *9 B 9 9
B
9* 9B*9 999*
C
.9 .9 9
B
Met Leu Val Glu Ile Glu Asn Leu Thr 1 Ala Leu Ala
LYS
65 Asp
LYS
LYS
Gly Ser 145 Arg Ser Asp Val Glu 225 Leu Asp Leu Gly 35 Gly Leu Ile Gly Phe Leu Asp Phe Arg Phe 115 Met Arg 130 Leu Tyr Glu Glu Leu Leu Sen Ala 195 Gly Glu 210 Asn Pro Asn Ile Asp Phe 100 Ser Glu Leu le Val 180 Ile Leu 5 Ile Asn Leu Giu Pro Ser Val
LYS
Phe Phe 165 Sen Phe Lys Ser Gly Asn Thr 70 Lys Asp Pro Leu Asp 150 Glu Thr Leu Lys Leu Ala Tyr 55 Lys Leu Phe Leu Gin 135 Glu Leu His Lys Gly 215 Lys Gly 40 Gin Lys Thr Asp
LYS
120 Leu Pro Ile Leu G lu 200 Leu 25 Lys Gly Sen Pro Giu 105 Arg Ile Val Ala Val 185 Ala Ser Lys 10 Pro Thr Glu Val Leu 90 Ser Glu Leu Ala Lys 170 Val Lys Ser Thr Tyr Gly Ser Leu Lys Lys Thr Val Ala 75 Lys Lys Phe Thr Gly 155 Glu Asp Val Leu Gln Leu Lys Phe Ala Ala Lys Leu 140 Ile Phe Val Val1 Glu 220 Gin Leu Ile Leu Ile Leu Ala 125 Ser Asp Ser Glu Ala 205 Ala Phe Lys Leu Ser Ala Asn 110 Leu Arg Pro Gin Lys 190 Phe Ala Ile Gly Ile Leu Asn Gin Asp Gly Phe Tyr Leu Leu Ser Lys Asn Ala Ile Ala 160 Asn Ala 175 Tyr Leu Gly Asp Tyr Lys Arg Leu Lys INFORMA.TION FOR SEQ ID 140:524: SEQUENCE CHARACTERISTICS: LENGTH: 273 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...273 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:524 g L Met 1 Ala Tyr Asp Leu 65 Leu Ser Ile Lys Arg 145 Trp Ala Lys Asn Lys 225 Leu Asn Pro Asn Asp His Phe 50 Lys Lys Ile Arg Thr i 130 His Glu Leu Tyr Asn 210 Ile Asn Pro Leu Asn Glu Asn Thr Asn 100 Gin Tyr Phe Asp Leu 180 Leu Leu Gin Leu Ile 260 5 Asn Lys Met Gly Phe 85 Ser Ser Val Asp Phe 165 Ser Ser Trp Ile Asp 245 Leu Asp Leu Gly Leu 70 Lys Leu Ser Leu Phe 150 Ala Ser Val Gin Ile 230 Gly Lys Lys Phe Arg 55 Leu Ala Asn Ser Asp 135 Met Leu Asp Asn Pro 215 Ala Val Asn Ile Leu Leu Ser Ser Met Gly 120 Pro Asp Gin Pro Gin 200 Lys Lys Arg Gly Glu 25 Glu Asp Phe Ser Met 105 Glu Asn Ile Lys Val 185 Asn Ile Glu Phe Ile 265 Lys Leu Phe Leu Ala Phe Ile Val Gly Leu Leu Leu Phe 75 Pro Tyr Val Leu Arg 155 Lys Phe Tyr Phe Arg 235 His Val Gly Met Phe Lys Asp Leu Ser Phe Ile 140 Val *Leu Lys Leu Tyr 220 Gin Ile Val Met Gly Lys Leu Lys Ala Tyr Ser 125 Glu Ser Pro Glu Lys 205 Asp Gin Thr Phe Leu Glu Asn Leu Pro Phe Val 110 Tyr Thr Leu Asn Ala 190 Ile Glu Glu Asp Asp 270 Leu Arg Arg Asn Ser Ala Leu Glu Met Lys Ala 175 Ser Ser Asn Ile Ala 255 Ala Ser Ser Lys Thr Val Lys Pro Leu Lys Glu 160 Arg Gly Ser Leu Ala 240 Lys Met *C C 4 INFORMATION FOR SEQ ID NO:525: SEQUENCE CHARACTERISTICS: LENGTH: 15 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...15 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:525 Val Ser Arg Pro Phe Lys Thr Ile Lys Lys Pro Pro Gin Pro Pro 1 5 10 INFORMATION FOR SEQ ID NO:526: SEQUENCE CHARACTERISTICS: LENGTH: 114 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...114 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:526 Met Unk Thr His Asp Arg Arg Lys Leu Arg Ile Unk Leu Thr Gin Thr 1 5 10 Thr Thr Leu Val Ala Thr Ile Gly Ser Asn Ala Pro Tyr Ile Gly Leu 20 25 Leu Gly Thr Val Met Gly Ile Met Leu Thr Phe Met Asp Leu Gly Ser 40 Ala Ser Gly Ile Asp Thr Lys Ala Ile Met Thr Asn Leu Ala Leu Ala 50 55 Leu Lys Ala Thr Gly Met Gly Leu Leu Val Ala Ile Pro Ala Ile Val 70 75 Ile Tyr Asn Leu Leu Val Arg Lys Ser Glu Ile Leu Val Thr Lys Trp 90 Asp Ile Phe His His Pro Val Asp Thr Gin Ser His Glu Val Tyr Ser 100 105 110 Lys Ala INFORMATION FOR SEQ ID NO:526: SEQUENCE CHARACTERISTICS: LENGTH: 114 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: 438 ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...114 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:526 Met Unk Thr His Asp Arg Arg Lys Leu Arg Ile Unk Leu Thr Gin Thr 1 5 10 Thr Thr Leu Val Ala Thr Ile Gly Ser Asn Ala Pro Tyr Ile Gly Leu 25 Leu Gly Thr Val Met Gly Ile Met Leu Thr Phe Met Asp Leu Gly Ser 40 Ala Ser Gly Ile Asp Thr Lys Ala Ile Met Thr Asn Leu Ala Leu Ala 55 Leu Lys Ala Thr Gly Met Gly Leu Leu Val Ala Ile Pro Ala Ile Val 70 75 Ile Tyr Asn Leu Leu Val Arg Lys Ser Glu Ile Leu Val Thr Lys Trp 90 Asp Ile Phe His His Pro Val Asp Thr Gin Ser His Glu Val Tyr Ser 100 105 110 Lys Ala INFORMATION FOR SEQ ID NO:527: SEQUENCE CHARACTERISTICS: :o LENGTH: 67 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...67 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:527 Met Ile Ala Val Leu Pro Pro Leu Phe Ser Met Gly Ser Phe Asp Glu 1 5 10 S Trp Ile Tyr Arg Gly Leu Val Ala Leu Met Val Ser Cys Pro Cys Ala 25 Leu Val Ile Ser Val Pro Leu Gly Tyr Phe Gly Gly Val Gly Ala Ala 40 Ser Arg Lys Gly Ile Leu Met Lys Gly Val His Val Leu Glu Gly Ala 55 Tyr Pro Asn INFORMATION FOR SEQ ID NO:528: SEQUENCE CHARACTERISTICS: LENGTH: 323 amino acids TYPE: amino acid TOPOLOGY: linear
I
439 (ii) (iii) MOLECULE TYPE: protein HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/K'EY: misc-feature LOCATION .323 Val
I
Leu Ala Gin Lys Lys Arg
LYS
Lys Leu 145 Thr Lys Ala Ala Ile 225 met Ile Phe Ser Phe 305 met (xi) SE( Gin His Phe Thr Tyr Phe Asn Gin His Ala Ala Asp Pro Lou Asn Tyr 115 Giu Ile 130 Lou His Lou Glu Asn Tyr Lys Ile 195 Lou Asn 210 Asp Thr Asn Ile Ala Arg Glu Lou 275 Leu Thr 290 Giu Ser Val Ala Phe Asn Phe Leu Tyr Lys Asp Sen Leu Pho Sor Ile Ala Ile Lys Giu Pho Ile Ala Gin Asn Asp Val 170 Ile Son G iu Val Lys 250 Asp Leu His Tyr Leu Phe Asn Lou Lou Val1 Lys Val1 Tyr 155 Pro Glu Lou Asn Ile 235 His His His Cys Gin 315 2UENCE DESCRIPTION: SEQ ID NO:528 INFORMATION FOR SEQ ID NO:529: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 10 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...10 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:529 Met Glu His Leu Thr Arg Gly Ile Lys His 1 5 INFORMATION FOR SEQ ID NO:530: SEQUENCE CHARACTERISTICS: LENGTH: 12 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...12 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:530 Val Val Ile Leu Gly Ser His Gly Lys Glu Glu Tyr 1 5 INFORMATION FOR SEQ ID NO:531: SEQUENCE CHARACTERISTICS: LENGTH: 79 amino acids TYPE: amino acid TOPOLOGY: linear MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...79 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:531 Met Lys Lys Val Ile Val Ala Leu Gly Val Leu Ala Phe Ala Asn Val 1 5 10 Leu Met Ala Thr Asp Val Lys Ala Leu Val Lys Gly Cys Ala Ala Cys 25 His Gly Val Lys Phe Glu Lys Lys Ala Leu Gly Lys Ser Lys Ile Val 40 Asn Met Met Ser Glu Lys Glu Ile Glu Glu Asp Leu Met Ala Phe Lys 55 Ser Gly Ala Asn Lys Asn Pro Val Met Thr Arg Lys Leu Lys Asn 70 INFORMATION FOR SEQ ID NO:532: SEQUENCE CHARACTERISTICS: LENGTH: 95 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...95 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:532 Met Gly Ile Ala Thr Ser Leu Ile Ser Glu Val Ser Lys Phe Tyr Tyr 1 5 10 Ala Leu Lys Tyr His Ala Lys Phe Met Ser Leu Gly Leu Geu Gly Cys 25 STyr Ala Ser His Tyr Ser Leu Trp Gin Lys Cys Ile Glu Leu Asn Glu 40 Ala Ile Cys Ile Leu Glu Asp Asp Ile Thr Leu Lys Glu Asp Phe Lys 55 Glu Gly Leu Asp Phe Leu Glu Lys His Ile Gln Glu Leu Gly Tyr Ala 70 75 Arg Leu Met His Leu Leu Tyr Asp Ala Ser Val Lys Ser Glu Pro 85 90 INFORMATION FOR SEQ ID NO:533: SEQUENCE CHARACTERISTICS: LENGTH: 154 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...154 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:533 Met His Leu Lys Ser Gly Ala Val Phe Ile Ser Asp Ala His Phe Leu 1 5 10 Pro Lys Ser Pro His Leu Ile His Thr Leu Lys Glu Leu Leu Ser Ala .25 442 Lys Pro Pro Gin Val Phe Phe Met Gly Asp Ile Phe His Val Leu Val 40 Gly Tyr Leu Pro Leu Asp Lys Glu Gin Gin Lys Ile Ile Asp Leu Ile 55 His Ala Leu Ser Glu Ile Ser Gin Val Phe Tyr Phe Glu Gly Asn His 70 75 Asp Phe Ser Met Arg Phe Val Phe Asn Ser Lys Val Met Val Phe Glu 90 Arg Gin Asn Gin Pro Ala Leu Phe Gin Tyr Asp Asn Lys Arg Phe Leu 100 105 110 Leu Ala His Gly Asp Leu Phe Ile Thr Lys Ala Tyr Glu Phe Tyr Ile 115 120 125 Thr Gin Leu Thr Ser Thr Trp Ala Arg Phe Phe Leu Thr Phe Leu Asn 130 135 140 Leu Leu Ser Phe Lys Thr Leu Tyr Pro Phe 145 150 INFORMATION FOR SEQ ID NO:534: SEQUENCE CHARACTERISTICS: LENGTH: 67 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein S(iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...67 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:534 Met Gin Asp Leu Asp Asn Asn Met Ser Leu Asp.Thr Ala His Asn Thr 1 5 10 Leu Ser Ser Asn Gly Lys Asn Ile Thr Ile Ala Gly Val Val Lys Ala 25 Leu Gin Lys Ile Gly Val Ser Ala Lys Gly Met Val Ser lle Leu Gin 40 Ala Leu Lys Lys Ser Gly Ala Ile Ser Ala Lys Trp Arg Tyr Tyr Asp 55 Lys Gin Gin INFORMATION FOR SEQ ID NO:534: SEQUENCE CHARACTERISTICS: LENGTH: 67 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: I I NAME/KEY: misc_feature LOCATION 1...67 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:534 Met Gin Asp Leu Asp Asn Asn Met Ser Leu Asp Thr Ala His Asn Thr 1 5 10 Leu Ser Ser Asn Gly Lys Asn Ile Thr Ile Ala Gly Val Val Lys Ala 25 Leu Gin Lys Ile Gly Val Ser Ala Lys Gly Met Val Ser Ile Leu Gin 40 Ala Leu Lys Lys Ser Gly Ala Ile Ser Ala Lys Trp Arg Tyr Tyr Asp 55 Lys Gin Gin INFORMATION FOR SEQ ID NO:535: SEQUENCE CHARACTERISTICS: LENGTH: 313 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...313 0 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:535 Val Gin Pro Met Lys Ser Lys Lys Leu Tyr Leu Ala Leu Ile Ile Gly 1 5 10 Val Leu Leu Ala Phe Leu Thr Leu Ser Ser Trp'Leu Gly Asn Ser Gly 25 Leu Val Gly Arg Phe Gly Val Trp Phe Ala Ala Ile Asn Lys Lys Tyr 35 40 Phe Gly Tyr Leu Ser Leu Ile Asn Leu Pro Tyr Leu Ala Trp Val Leu o 50 55 Phe Leu Leu Tyr Arg Ala Lys Asn Pro Phe Thr Glu Ile Val Leu Glu 70 75 Lys Thr Leu Gly His Leu Leu Gly Ile Leu Ser Leu Leu Phe Leu Gin 85 90 Ser Ser Leu Leu Asn Gin Gly Glu Ile Gly Asn Ser Ala Arg Leu Phe 100 105 110 Leu His Pro Phe Ile Gly Asp Phe Gly Leu Tyr Val Leu Ile Met Leu 115 120 125 Met Val Val Ile Ser Tyr Leu Ile Leu Phe Lys Leu Pro Pro Lys Ser 130 135 140 Val Phe Tyr Pro Tyr Met Asn Lys Thr Gin Ser Leu Leu Lys Glu Ile 145 150 155 160 Tyr Lys Gin Cys Leu Gin Ala Phe Ser Pro Asn Phe Ser Leu Lys Lys 165 170 175 Glu Gly Phe Glu Asn Thr Pro Ser Asp Ser Gin Lys Lys Glu Thr Asn 180 185 190 Asn Asp Lys Glu Lys Glu Asn Leu Lys Glu Asn Pro Ile Asp Glu Asn 195 200 205 His Asn Thr Pro Asn Glu Glu Ser Phe Leu Ala Ile Pro Thr Pro Tyr 210 215 220 As n 225 Ser Phe Lys Pro Lys 305 Thr Pro Asp Giu Ile 290 Thr 444 Pro Gin Giu Gly Leu Vai Gin Ile 235 240 Thr Ile Tyr Pro Lys Arg Asn Arg 250 255 Leu Lys Giu Pro Lys Gin Giu Thr 265 270 Lys Giu Thr Pro Thr Thr Leu Lys 285 Thr Gin Lys Ile Met Thr Lys Gin 300 Pro INFORMATION FOR SEQ ID NO:536: SEQUENCE CHARACTERISTICS: LENGTH: 319 amino acids TYPE: amino acid TOPOLOGY: iinear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Heiicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .319 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:536 1Vai Met Leu Ser Arg Asp Ile Vai Gin Tyr Ser Lys C C 0* S0C Leu Leo Gin Gly Giu His
LYS
Leo Ala 145 Ser Met Phe Ser Ala 225 Tyr Pro Ala Met Gly Val Arg Val 130 Phe Ser Val Phe 210 Leu Leo Thr Thr Leo Lys Met Leo Lys 70 Glu His 85 Ser Asp Leu Thr Ala Ser Cys Leo 150 Lys T1yr 165 Ile Ser Ile Sen Lys Gbu Phe Asp Tyr Asp Ala 55 Pro Asp Lys Asp Tyr 135 Gin Phe Ile Ser Val1 215 Leo Leo Tyr 40 Lys Ser Leo Tyr Pro 120 Pro Ile Lys Met Phe 200 Phe Val Ser Asn Phe Phe Glu 90 Phe Pro Tyr Leo Phe 170 Thr Thr Pro Ala His Asn Arg. Gin Phe Val Lys Glu 75 Gly Ile Tyr Gin Sen Lys Asp Gin 140 Ang Val 155 Ser Glu Leo Val Ala Ile Ile Val 220 Ile Phe Ile Ile Ile Leu Gin G lu Ala Lys 125 Asn Ala Gly Ser Val 205 Leo Glu Thr Asn Lys Ala His Glu Asn Asn Asp Glu Met 175 Leo Phe Thr Glu Gbu His Met Lys Lys Ser Glu His Leu Ile 160 Val Leu Ser Leo Val 230 235 240 Leo Gly Lys Asn Sen Oly Asp Asn His His Ala Ile His Ang Thn Met 245 250 255 Ile Arg Phe Leu Gly Ser Ile Ile Ile Ala Leu Ala Ile Glu Ala Leu 260 265 270 Met Leu Val Phe Lys Phe Ser Val Ser Glu Pro Asp Lys Ile Thr Tyr 275 280 285 Ala Val Tyr Leu Ala Ile Gly Val Ala Val Leu Leu Ile Ser Leu Ala 290 295 300 Ile Tyr Val Lys Phe Ala Tyr Ser Val Leu Pro Lys Arg Glu Arg 305 310 315 INFORMATION FOR SEQ ID NO:537: SEQUENCE CHARACTERISTICS: LENGTH: 118 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...118 S* (xi) SEQUENCE DESCRIPTION: SEQ ID NO:537 S0! Met Val Ile His Glu Lys Ile Lys Ser Arg Phe Ser Arg Asn Trp Ser 1 5 10 S*Leu Arg Asn Arg Gly Arg His Phe Ala Ser Ser Ser Val Tyr Phe Phe 20 25 Ser Leu Leu Val Ile Thr Ala Val Asn Arg Ser Ser Ala Val Ala Trp 40 Leu Leu Met Pro Glu His Leu Ile Gly Trp Phe Leu Ile Ser Phe Ser 50 55 Gly Glu Phe Val Ala Asp Met Ala Phe Gly Lys'Lys Ser Lys Ile Phe 70 75 Lys Thr Arg Phe Gly Ile Ser Ile Val Ser Gly Val Ser Leu Leu Leu 85 90 Gly Ala Tyr Gin Arg Phe Tyr Phe Leu Tyr Gly Leu Ala Leu Leu Ile 100 105 110 Gly Gly Leu Ser Phe Leu 115 INFORMATION FOR SEQ ID NO:538: SEQUENCE CHARACTERISTICS: LENGTH: 88-amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature Leu Leu Asn Ile His Phe LOCATION .88 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:S38 His Pro Leu Ala Asp Val Phe Val Val Asn 10 Ala Met Val Unk Met Leu Ile Unk Ser Leu 25 Tyr Leu Phe Ile Phe Unk Leu Glu Val Gly 40 Val Thr Val Ilie Gly His Ala Ile Gly Gly 55 Phe Trp Arg Lys Lys Gly Giu Leu Tyr Phe 75 Ile Phe Ser His Phe Phe Ser
A
A
V
L
6
I
INFORMATION FOR SEQ ID NO:538: SEQUENCE CHARACTERISTICS: LENGTH: 88 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .88 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:538 Leu His Pro Leu Ala Asp Val Phe Val Val Asn 1 5 10 Leu Ala Met Val Unk Met Leu Ile Unk Ser Leu 25 Asn Tyr Leu Phe Ile Phe Unk Leu Glu Val Giy 40 Ile Val Thr Val Ile Gly His Ala Ile Gly Gly 50 55 His Phe Trp Arg Lys Lys Gly Glu Leu Tyr Phe 70 75 Phe Ile Phe Ser His Phe Phe Ser INFORMATION FOR SEQ ID NO:539: Ci) SEQUENCE CHARACTERISTICS: CA) LENGTH: 92 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori sp Lys Arg Unk I is la Asn Ile Phe I al Gin Gly Unk2 eu Vai Leu Met 0 le Lys Leu Ile 4sp Lys Arg Unk Ala Asn Ile Phe Val Gin Gly Unk Leu Val Leu Met Ile Lys Leu Ile Tal 'he kla ;in Phe Val1 Phe Ala Gin Phe Met
I
Val Leu Tyr Giu Ala (ix) FEATURE: NAME/KEY: misc-feature LOCATION .92 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:539 Phe Lys Ser Arg Leu Asn Ser Trp Ile Leu 5 10 Leu Val Val Val Phe Trp Asp Val Ile Lys 25 Gin His Asp His Tyr Leu Ser Gin Val Lys 40 Lys Asn His Ile Giu Giu Ala Leu Lys Lys Lys Gly Giy Asp Lys Val Asp Cys Ser Ala4 70 75 Gly Giu Arg Asn Arg Arg Met Leu Giu Ile Gly Ile Leu Gly Lys Ile Glu Asp Arg Glu Glu Tyr Ser Glu Cys Phe Met Arg Ile Ala INFORMATION FOR SEQ ID NO:540: Wi SEQUENCE CHARACTERISTICS: LENGTH: 138 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .138 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:540 Met Val Phe Trp Gly Ala Val Phe Phe Leu Trp Asp Arg Thr Ala Trp
I
LYS
Leu Thr Gly 65 Val Asn Leu Sen Leu Leu 35 Gin Val Ile Met Ala 115 Leu Met Gly Ile Trp Val His 100 Ile Lys Val Ser Val Pro Pro Ala Phe Lys Phe Phe Leu Phe Ala Glu Ile Ala Leu Leu Ile Glu Ty'r Phe Val Cys 135 Asn Gly 40 Ser Sen His Ile Ser 120 Glu 10 Leu Trp Leu Pro Ile 90 Val Ile Ala Met Asn Ile Leu Leu His Val 125 Ala Ala Met Val Ang Tyr Lys INFORMATION FOR SEQ ID NO:541: Wi SEQUENCE CHARACTERISTICS: LENGTH: 276 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .276 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:541 1Met Leu Arg Lys Asn Ile Leu Ala Tyr Tyr Gly Ala Asn Phe Leu Leu
C
C
C
C
Ile Ser Ser Leu Ala.
Leu.
Ile Ser Ile 145 Leu Ile I.eu Asp Val 225 Gin Val
LYS
Ilie Lys Phe MIet Ser Ala Giu Lys 130 dly Tyr Ile
LYS
Asn 210 Phe Gly Ile
LYS
Ala Giy Cys~ Ser Phe Trp Ala 115 Phe Ser Val Tyr Leu 195 Pro Phe Val Sen Ser 275 .G1n ELeu Val Arg Ser Gly 100 Sen Leu Ser Val1 Phe 180 Leu Lys Met Lys Ile 260 Pro 3er 3er Lieu Lys Leu Leu Leu Ala Leu Gly 165 Lys Lys Leu Sen Glu 245 Pro .jeu Pro His Leu Val Asn 70 Val Tyr I le Lys Gly 150 Ile Giu C iu Lys His 230 Gin His Ser Ala 55 Leu Leu G ly Thr Asn 135 Ser Phe Lys Gin Ile 215 Phe Tyr Sen .Glu 40 Glu Phe Phe Leu Asp 120 Asn Phe Leu Glu Val 200 Leu Gin Leu Phe Ala 25 Ile Tyr Leu Phe Tyr 105 Ile Gin Leu Ile Gly 185
LYS
Leu Met Phe Phe 265 Ile Leu Pro Val Asp 90 Ser Lys Ile Tyr Met 170 Asp Gly Val Trp Val 250 Lys Leu Leu Sen Sen 75 Sen Ala G lu Thr Leu 155 Leu Phe Ser Giy Gin 235 Phe Sen rhr Val Gly Asn Phe Cys Asn Tyr 140 Lys Cys Lys Leu His 220 Ala Tyr Gin Pro Gin Val1 Val1 I le Ser Lys 125 Leu Val Ala Sen Lys 205 Leu Tyr Ile Lys Leu Thr Leu Phe Leu Sen 110 Lys Gly His Leu Gin 190 Giu Ile Phe Ala Leu 270 Leu Phe Ala Leu Met Gly Asp Met Ala Thn 175 Lys Leu Thr Leu Phe 255 Un Leu Phe Asp Ile Leu Thn Leu Ile Met 160 Ile Asn Lys Pro Lys 240 Gin Ala INFORMATION FOR SEQ ID NO:541: SEQUENCE CHARACTERISTICS: LENGTH: 276 amino acids TYPE: amuino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...276 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:541 Met Leu Arg Lys Asn Ile Leu Ala Tyr Tyr Gly Ala Asn Phe Leu Leu 1 5 10 Ile Ile Ala Gin Ser Leu Pro His Ala Ile Leu Thr Pro Leu Leu Leu 25 Ser Lys Gly Leu Ser Leu Ser Glu Ile Leu Leu Val Gin Thr Phe Phe 40 Ser Phe Cys Val Leu Val Ala Glu Tyr Pro Ser Gly Val Leu Ala Asp 55 Leu Met Ser Arg Lys Asn Leu Phe Leu Val Ser Asn Val Phe Leu Ile 70 75 Ala Ser Phe Ser Leu Val Leu Phe Phe Asp Ser Phe Ile Leu Met Leu 90 Leu Ala Trp Gly Leu Tyr Gly Leu Tyr Ser Ala Cys Ser Ser Gly Thr 100 105 110 Ile Glu Ala Ser Leu Ile Thr Asp Ile Lys Glu Asn Lys Lys Asp Leu 115 120 125 Set Lys Phe Leu Ala Lys Asn Asn Gin Ile Thr Tyr Leu Gly Met Ile 130 135 140 Ile Gly Ser Ser Leu Gly Ser Phe Leu Tyr Leu Lys Val His Ala Met 145 150 155 160 Leu Tyr Val Val Gly Ile Phe Leu Ile Met Leu Cys Ala Leu Thr Ile 165 170 175 Ile Ile Tyr Phe Lys Glu Lys Glu Gly Asp Phe Lys Ser Gin Lys Asn 180 185 190 Leu Lys Leu Leu Lys Glu Gin Val Lys Gly Ser Leu Lys Glu Leu Lys 195 200 205 Asp Asn Pro Lys Leu Lys Ile Leu Leu Val Gly His Leu Ile Thr Pro 210 215 220 Val Phe Phe Met Ser His Phe Gin Met Trp Gin Ala Tyr Phe Leu Lys 225 230 235 240 S Gin Gly Val Lys Glu Gin Tyr Leu Phe Val 'Phe Tyr Ile Ala Phe Gin 245 250 255 Val Ile Ser Ile Pro His Ser Phe Phe Lys Ser Gin Lys Leu Unk Ala 260 265 270 Lys Lys Ser Pro 275 INFORMATION FOR SEQ ID NO:542: SEQUENCE CHARACTERISTICS: S: LENGTH: 254 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...254 450 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:542 Met His Glu Gin Giv Ser Ile Ser Phe Ile Gly Glu Gin Gly Ala Lys 1 Arg Lys Ala Ile Asp Val Tyr Glu Lys 145 Lys Val Ser Lys Tyr 225 Leu Ile Arg Glu Tyr Met Gly Ser 130 Thr Cys Leu le Lys 210 Arg Leu Ala Thr Val Arg Tyr Phe 115 Leu Leu Ile Asn Leu 195 Ser Leu Tyr Leu Leu Ile Glu Leu 100 Asp Pro Leu Leu Ile 180 Ile Leu Lys 5 Ile Asp Ile Lys Leu Arg Phe Arg Asp Leu 165 Glu Gin Leu Tyr Asn 245 Leu Arg Lys Gly 70 Glu Gin Thr His Tyr 150 Ile Leu Gly Glu Phe 230 Tyr His Asn 55 Lys Cys Phe Leu Leu 135 Lys Val Lys Lys Pro 215 Asn Lys Tyr 40 Val Gin Leu Phe Lys 120 Asn Pro Ile His Gly 200 Ser Gly Leu 25 Ala Asn Arg Val Asp 105 Asn Asp Ala Leu Ile 185 Arg Leu Ala 10 Ala Lys Ile Tyr Lys 90 Tyr Leu Lys Thr Gly 170 Gin Lys SAsn Tyr Tyr 250 Phe Met Leu Leu 75 Ser Leu Ala Asp Ser 155 Gly Val Glu Ala Leu 235 Asn Phe Glu Tyr Lys Asp Phe Leu 140 Phe Leu Glu Arg Trp 220 Phe Ala Leu Glu Val Met Arg Ala 125 Lys Glu Arg Glu Lys 205 Ile Lys Lys Gin Gin Tyr Ala Lys 110 Lys Ser Lys Lys Gin 190 Ala Ser Lys Pro Ser Val Gly Leu Lys Arg Thr Phe Arg Cys 175 Asn Tyr Asp Asp Asn Val Phe Lys Tyr Arg Lys Leu Asn 160 Glu Tyr Ile Asp Lys 240
S
S
*SS S Gin Lys Ser Gin Ser Leu Thr Leu Asn Leu Ser INFORMATION FOR SEQ ID NO:543: SEQUENCE CHARACTERISTICS: LENGTH: 185 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY:-misc_feature LOCATION 1...185 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:543 Val Val Phe Lys Ile Leu Ser Leu Trp Leu Gly Val Phe Cys Phe Leu 1 5 10 Arg Ala Thr His Leu Tyr Leu Gly Glu Glu Pro Lys Tyr Lys Asp Asn 25 Phe Thr His Phe Glu Tyr Ala Asn Pro Asn Ala Arg Lys Gly Gly Val 40 Leu Arg Asn Asp Ala Ile Gly Thr Phe Asp Ser Leu Asn Pro Phe Ala 55 Leu Lys Gly Thr Lys Ala Glu Gly Leu Asp Leu Ile Tyr Asp Thr Leu 70 75 Met Val Gin Ser Leu Asp Glu Pro Phe Ala Glu Tyr Pro Leu Ile Ala 90 Lys Asp Ala Glu Val Ala Lys Asp Asn Ser Tyr Val Ile Phe Thr Leu 100 105 110 Asp Lys Arg Ala Arg Phe Ser Asn Asn Ala Pro Ile Leu Ala Ser Asp 115 120 125 Val Lys Phe Ser Phe Asp Thr Ile Met Lys Leu Gly Ser Pro Leu Tyr 130 135 140 Arg Gin Tyr Tyr Gin Asp Val Lys Lys Ala Val Ile Leu Asp Lys His 145 150 155 160 His Val Lys Phe Ile Tyr Lys Thr Thr Glu Asn Lys Glu Leu Pro Leu 165 170 175 Ile Leu Gly Gin Leu Gin Ile Phe Ser 180 185 INFORMATION FOR SEQ ID NO:544: SEQUENCE CHARACTERISTICS: LENGTH: 37 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...37 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:544 Val Ala Met Ile Asp Cys Ala Ile Ile Gly Gly Gly Pro Ala Gly Leu 1 5 10 Ser Ala Gly Leu Tyr Ala Thr Arg Gly Gly Val Lys Asn Ala Val Leu 20 25 Phe Glu Lys Gly Met INFORMATION FOR SEQ ID NO:545: SEQUENCE CHARACTERISTICS: LENGTH: 93 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...93 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:545 Leu 1 Leu Phe His Tyjr Unk Tyr Pro Giu Asn Ile Glu Gly Asn Phe Tyr Phe Lys Gly 5 His Giy Ser Ile Lys Leu Gly 70 Gly Val1 Giu Lys Lys Giu Trp Lys As n Phe Ala Ile Gly Met 10 Thr Arg Ile Ser Lys 452 Gly Val Thr Ile Asp Trp Arg Glu Ile Glu 75 Asn Gly Leu Ser Thr Pro Lys Thr Val Asp Leu Ser Ser Asn Lys Phe Unk Ser
S
S S
S
S
S
*5 S S *SS S INFORMATION FOR SEQ ID NO:545: SEQUENCE CHARACTERISTICS: CA) LENGTH: 93 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAM.E/KEY: misc-feature LOCATION 1. 93 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:545 Leu Tyr Pro Pro Gly Sen Val Val Lys Met Gly 1 5 -10 Leu Glu Asn Leu His Ile Thr Giu Asn Thr Thr 20 25 Phe Ile Glu Val Gly Lys Arg Lys Phe Ang Asp.
35 40 His Gly Asn Sen Asn Leu Tyr Lys Ala Ile Arg 50 Tyr Phe Tyr Lys Phe Gly Leu Glu Ile Sen Ile 70 75 Unk Phe Lys Unk Sen Gly Leu Trp Gly Lys Asn INFORMATION FOR SEQ ID NO:546: SEQUENCE CHARACTERISTICS: LENGTH: 182-amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc...feature LOCATION 182 Phe Pro Gly Val1 Lys Phe Pro Gly Val1 Lys Gly Leu Sen Pro Thr Pro Lys Lys Thr Ser Val Asp Unk Leu Ser Arg (xi) SEQUENCE DESCRIPTION: SEQ ID NO:546 Val Gly Lys Ser Leu Arg Tyr Ser Leu Asn Leu Asp Leu Asn Gin Lys 1 510 Ala Asp Leu Phe Phe Thr Giu Leu Giu Pro Thr Gly Leu Thr Leu Ser 25 Pro Ile Met Lys Arg Phe Thr Ile Lys Gly Asp Phe Asp Ser Gly Leu 40 Lys Ser Tyr Asp Met Ser Tyr Met Tyr Ala Ser Leu Gin Ala Ile Ser s0 55 Ala Ile Arg Arg Leu Pro Leu Gly Leu Tyr Asp Gly Val His Val Tyr 70 75 Ser Lys Thr Pro Met Lys Asp Ile Glu Lys Leu Arg Asn Ala Leu Lys 90 Thr Ile Asn His His ly Ile ly Ile Glu Gly Trp Trp Gin Gin Asn 100 105 110 Gly Asn Phe Phe Ser Ala Met Giu Leu Glu Lys Arg Ala Leu Phe Ile 115 120 125 Val Leu Met Leu Ilie Ile Leu Met Ala Ser Leu Asn Ile Ile Ser Ser 130 135 140 Leu Leu Met Val Val Met Asn Arg Arg Lys Giu Ile Ala Leu Leu Phe 145 150 155 160 Ser Met Gly Ser Ser Gin Lys Giu Ile Gin Lys Thr Phe Phe Tyr Leu 165 170 175 Gly Asn Ile Ile Ser Leu 180 INFORMATION FOR SEQ ID NO:547: SEQUENCE CHARACTERISTICS: LENGTH: 247 amino acids TYPE: amino acid TOPOLOGY: linear :**woo (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: 55:5(A) ORGANISM: Helicobacter pylori (ix) FEATURE:.
NAME/KEY: misc-feature LOCATION .247 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:547 *Met Lys Lys Thr Phe Leu Ile Ala Leu Ala Leu Thr Ala Ser Leu Ile 1 S 10 Gly Ala Giu Asn Thr Lys Trp Asp Tyr Lys Asn Lys Glu Asn Gly Pro -25 His Arg Trp Asp Lys Leu His Lys Asp Phe Glu Val Cys Lys Ser Gly 40 Lys Sen Gin Ser Pro Ile Asn Ile Glu His Tyr Tyr His Thr Gin Asp so 55 Lys Ala Asp Leu Gin Phe Lys Tyr Ala Ala Ser Lys Pro Lys Ala Val 70 75 Phe Phe Thr His His Thn Leu Lys Ala Ser Phe Giu Pro Thr Asn His 90 Ile Asn Tyn Arg Giy His Asp Tyr Val Leu Asp Asn Val His Phe His 100 105 110 Ala Pro Met Giu Phe Leu Ile Asn Asn Lys Thr Arg Pro Leu Ser Ala 115 120 125 His Lys Glu Gly Lys Lys 165 Ser Ile 180 Thr Giu Ala Lys Gin Arg Ala Glu 245 454 Leu Leu 140 Leu Asp 155 Val Ala Asn Gly Val Ile Lys Lys 220 Tyr Asn 235 Val1 Pro Leu Ser Giu 205 Arg Thr Ala Leu Ala 175 Thr Pro Lys Ile INFORMATION FOR SEQ ID NO:548: Wi SEQUENCE CHARACTERISTICS: LENGTH: 422 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .422 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:548 *5 S S
S
S. S. 55 S S
S
5*S S S *5
SSSS
S
S. S Met Lys Ile Sen Leu Leu Gly His Gly 1 Arg Phe
LYS
Ile Glu Met Leu Gly Leu 145 Leu Cys Met Phe Pro Asp s0 Sen Tyr Ile Thn Thr 130 Giu Ile Asn Pro Phe Ala Phe Phe Asp Ser Tbn 115 Pro Thr Tyr Phe Lys 195
S
Lys Phe Pro His Ile Ser Leu Ile Ser Leu 165 Asn Ser Glu 25 Glu Gin Met Phe Gly 105 Lys Glu His Giu Ala 185 Leu Thn. Thr Leu Lys Phe Phe Phe Leu Cys Glu Ile Val Ala Lys His 75 His Ser Phe Thr Thr Thr Val Ser Gly 125 Ang Ser Pro 140 Thr Asn Lys 155 Asp His Leu Leu Lys Val Leu Lys Phe 205 Ala Asp Ser Leu Thr Thr 110 Gly Leu Ala Thr Leu 190 Lys Leu Asp Pro Pro Met Pro Giu Asn Trp Tyr Trp 175 Thr Glu Gly Lys Ser Gly Ser Thr Met Ile Val Pro 160 His Leu His Pro Ile Val Gin Asn Ser Gin Ala Gin Lys Ile Phe Phe Asp Lys Sen WO 96/40893 455 210 215 220 Glu Glu Val Leu Glu Cys Leu Lys Ile Pro Ser Asn Ala Leu Phe Phe 225 230 235 240 Lys Gly Ala Phe Leu Leu Asp Ala Ala Leu Ala Leu Leu Val Tyr Glu 245 250 255 Gin Phe Leu Lys Ile Lys Asn Leu Lys Trp Gin Asp Tyr Arg Glu Asn 260 265 270 Ala Leu Lys Arg Leu Asn Ala Phe Lys Ile Gly Ser His Lys Met Glu 275 280 285 Glu Phe Arg Asp Lys Gin Gly Arg Leu Trp Val Asp Asp Ser Lys Ala 290 295 300 Thr Asn Ile Asp Ala Thr Leu Gin Ala Leu Lys Thr Phe Lys Asn Gin 305 310 315 320 Lys Ile His Leu Ile Leu Gly Gly Asp Ile Lys Gly Val Asn Leu Thr 325 330 335 Pro Leu Phe Glu Glu Phe Lys Asn Tyr Lys Ile Ser Leu Tyr Ala Ile 340 345 350 Gly Ser Ser Ala Ser Ile Ile Gin Ala Leu Ala Leu Glu Phe Asn Val 355 360 365 Ser Cys Gin Val Cys Leu Lys Leu Glu Lys Ala Val Gin Glu Ile Lys 370 375 380 Ser Val Leu Leu Gin Asn Glu Val Ala Leu Leu Ser Pro Ser Ala Ala 385 390 395 400 Ser Leu Asp Gin Phe Ser Ser Tyr Lys Glu Arg Gly Glu Lys Phe Lys 405 410 415 Ala Phe Val Leu Lys Asp 420 INFORMATION FOR SEQ ID NO:549: SEQUENCE CHARACTERISTICS: LENGTH: 60 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...60 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:549 S. Met Ala His His Unk Glu Gin His Gly Gly His His His His His His 1 5 10 His Thr His His His HisTyr His Gly Gly Glu His His His His His 25 His Ser Ser His His Glu Glu Gly Cys Cys Ser Thr Ser Asp Ser His 40 His Gin Glu Glu Gly Cys Cys His Gly Unk His Glu 55 INFORMATION FOR SEQ ID NO:549: SEQUENCE CHARACTERISTICS: LENGTH: 60 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...60 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:549 Met Ala His His Unk Glu Gin His Gly Gly His His His His His His 1 5 10 His Thr His His His His Tyr His Gly Gly Glu His His His His His 25 His Ser Ser His His Glu Glu Gly Cys Cys Ser Thr Ser Asp Ser His 40 His Gin Glu Glu Gly Cys Cys His Gly Unk His Glu 55 INFORMATION FOR SEQ ID NO:550: SEQUENCE CHARACTERISTICS: S* LENGTH: 54 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...54 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:550 Met Lys Glu Ile Ile Val Ala Leu Val Gly Gin Pro Asn Val Gly Lys S1 5 10 Ser Ser Leu Ile Asn Ala Leu Ser Asn Thr His Leu Lys Val Gly Asn 25 Phe Thr Glu Val Thr Val Asp Lys Met Glu Val Ser Leu Ile Gin Lys 40 Asp His Gin Ile Asn Ser INFORMATION FOR SEQ ID NO:551: SEQUENCE CHARACTERISTICS: LENGTH: 297 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: HeJlicobacter pyloni (ix) FEATURE: NAME/KEY: miscfeature LOCATION .297 (xi) SEQUENCE DESCRIPTION: SEQ ID Val Lys Ile Arg Leu Phe Asp Phe Thr Ile Arg 5 10 Phe His Ile Phe Asp Phe Leu Lys Gly Ile Arg 25 Trp Met Gin Asn His Arg Lys Tyr Leu Val Val Leu 1 Glu ciii Leu Phe Lys Pro 1s Val. Leu Met Ile Thr Ile Trp Ile Ser Ser Ile Tyr Lys Ala Gin 145 Giy Tyr Thr Phe Ser Ala Ala Leu 130 Giu Val Arg Ile Ser Gin Glu Met 115 Leu Val1 Phe Pro 40 Ala P Leu A Glu G Ser 100 His I Arg Ala Asp Lys 180 Ser Ser Pro Tyr rArg 260 ux Leu 5 k Gly he I .sp S 7 ;iu L :le P jeu C ksn Lys Glu 165 His Ala Leu Asn Glu 245 Ser Glu Glu le er 0 eu ~ro u he Alu 150 Ala 55 Asp Ala Asp Lys Ala 135 Ile Leu Ala Gly Ser Ala Gin. Giu Phe Lys 105 Ser Ala 120 Leu Asp Arg Lys Tyr Lys Met Ala Tyr 90 G iu Leu Leu Thr Asn 170 Ile Lys 75 Arg Leu Asp Gly Asn 155 Ile Gly Val Arg Thr Ser Leu 140 Val Lev G ly Leu Giu Leu 125 Gdy Phe Lys Gin Lys Asp 110 Ile Ala Gin Gin Leu Ile Asp Gin Asn Thr Lys Ser 175 Ile Lys Ala Ile Gin Lys Asp 160 His Leu Phe Glu Glu Ser Val diii Arg Leu L19G0 i Gin Sen Ile 225 Lys Phe Leu Asp Lys Ile 195 Ser Leu 210 Leu Asr Lys Ty2 Lys Th: Lys Gil 27 Unk Un 290 Leu Phe Trp Ala 215 Asp Val 230 Asn His Leu Tyr Glu Tyr Ile Thr 295 Pro Lys 200 Lys Leu Lys Ile Arg Lys Phe Asp 265 Tyr His 280 Gly Phe Thr Gin Ser Asp 250 Ala Lys Thr Thr Asp Lys 220 Leu Asn 235 Phe Lys Ser Leu Asn Lys Pro 205 Leu diu Lys Glu Val 285 Asp Glu Pro Lys 270 Ser Ile Giu Thr 255 Thn Tyr Leu Met 240 Sen Asp Leu INFORMATION FOR SEQ ID NO:551: SEQUENCE CHARACTERISTICS: LENGTH: 297 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1..-297 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:551 Leu Val Lys Ile Arg Leu Phe Asp Phe Thr Ile Arg Leu Phe Giu Giu Ser Ser Ilie Tyr Lys Ala Gin 145 Giy Tyr Gin Ser Ile 225
LYS
Phe Leu Asp Phe His Ile Trp Met Gin Thr Ile Ala Phe Ser Leu Ser Gin Glu Ala Glu Ser 100 Ala Met His 115 Leu Leu Arg 130 Giu Vai Ala Val Phe Asp Arg Pro Lys 180 Lys Ile Ser 195 Ser Leu Ser 210 Leu Asn Pro Lys Tyr Tyr Lys Thr Arg 260 Lys Giu Leu 275 Unk Unk Gly 290 Phe Asn Phe Asp Glu Ile Leu Asn Lys G lu 165 His Ala Leu Asn Giu 245 Ser Glu Asp His Ile Ser 70 Leu Pro Glu Phe G lu 150 Glu Phe Leu Trp Asp 230 Asn Leu Giu Phe Arg Ala 55 Asp Ala Asp Lys Ala 135 Ile Leu Giu Phe Ala 215 Val1 His Tyr Tyr Leu Lys 40 Ala Ser Gin Phe Ser 120 Leu Arg Tyr Glu Pro 200 Lys Lys Arg Phe Tyr 280 Lys 25 Tyr Gly Ala G iu Lys 105 Ala Asp Lys Lys Ser Lys Leu Ile Lys Asp 265 His 1 Leu Met Ala Tyr 90 Glu Leu Leu Thr Asn 170 Val1 Thr Gin Ser Asp 250 Ala Ile Val Ile Lys 75 Arg Leu Asp Gly Asn 155 Ile Giu Thr Asp Leu 235 Phe Ser Arg Val1 Gly Val1 Arg Thr Ser Leu 140 Val1 Leu Arg Thr Lys 220 Asn Lys Leu Val1 Thr Trp, G ly Leu G iu Leu 125 Gly Phe Lys Leu Pro 205 Leu Glu Lys Glu Val1 285 Leu Ile Gly Gin Lys Asp Ile Ala Gin Gin Leu 190 Leu Asp Glu Pro Lys 270 Lys Pro met Ile Trp Ile Gin Tyr Ile Lys Asp Ala Gin Ile Asn Gin Thr Lys Lys Asp 160 Ser His 175 Ile Leu Giu Gin Ile Leu Giu Met 240 Thr Ser 255 Thr Asp
S.
S
*5 S
S
*SSS
S
*5 S S
S
Lys Asn. Lys Ser Tyr Leu Glu Ile Thr Gly Phe INFORMATION FOR SEQ ID NO:552: SEQUENCE CHARACTERISTICS: LENGTH: 90 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION (xi) SEQUENCE DESCRIPTION: SEQ ID NO:S52 Met Val Lys His Tyr'Leu Phe Met Ala Val Ser Gin Val Phe Phe Sen 1 5 10 Phe Phe Leu Val Leu Phe Phe Ile Ser Ser Ile Val Leu Leu Ile Ser 25 Ile Ala Ser Val Thr Leu Val Ile Lys Val Ser Phe Leu Asp Leu Val 40 Gin Leu Phe Leu Tyr Ser Leu Pro Gly Thr Ile Phe Phe Ile Leu Pro 55 Ile Thr Phe Phe Ala Ala Unk Arg Leu Gly Unk Ser Arg Leu Ser Tyr 70 75 Asp His Glu Leu Leu Val Phe Phe Leu Unk INFORMATION FOR SEQ ID NO:552: SEQUENCE CHARACTERISTICS: LENGTH: 90 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...90 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:552 Met Val Lys His Tyr Leu Phe Met Ala Val Ser Gin Val Phe Phe Ser 1 5 10 Phe Phe Leu Val Leu Phe Phe Ile Ser Ser Ile Val Leu Leu Ile Ser 20 25 Ile Ala Ser Val Thr Leu Val Ile Lys Val Ser Phe Leu Asp Leu Val 40 Gin Leu Phe Leu Tyr Ser Leu Pro Gly Thr Ile Phe Phe Ile Leu Pro 55 Ile Thr Phe Phe Ala Ala Unk Arg Leu Gly Unk Ser Arg Leu Ser Tyr 65 70 75 Asp His Glu Leu Leu Val Phe Phe Leu Unk INFORMATION FOR SEQ ID NO:553: SEQUENCE CHARACTERISTICS: LENGTH: 111 amino acids TYPE: amino acid TOPOLOGY: ltnear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...111 460 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:553 Val His Arg Phe Ser Arg Asn Pro Cys Ala Ser Cys Asn Arg Ala Arg 1 5 10 Ser Cys Ser Arg Leu Ser Arg Ser Leu Val Ser Ala Val Thr Trp Trp 25 Leu Ser Leu Ser Phe Ser Val Val Ser Ala Leu Phe Ser Leu Val Ser 40 Ser Val Ile Leu Trp Val Ser Ser Val Phe Ser Leu Phe Ser Leu Ser 55 Phe Ser Val Val Asn Ser Leu Phe Ser Ser Val Ser Arg Ser Leu Ala 70 75 Ala Asn Lys Arg Val Phe Ser Leu Ala Lys Met Ser Phe Ser Val Phe 90 Ser Ser Ala Phe Ser Leu Val Ser Leu Leu Leu Phe Cys His Asn 100 105 110 INFORMATION FOR SEQ ID NO:554: SEQUENCE CHARACTERISTICS: LENGTH: 137 amino acids TYPE: amino acid TOPOLOGY: linear S (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...137 S(xi) SEQUENCE DESCRIPTION: SEQ ID NO:554 Met Gin Lys Met Gly Val Val Ser Tyr Ser Val Phe Gin Ala Phe Glu 1 5 10 Lys Ala Leu Ser Arg Phe Lys Glu Gly Val Val Leu Ile Val Asp Ser 25 Leu Arg Arg Leu Ile Met Gly Ser Ala Ser Val Lys Glu Leu Ser Gly 40 Val Ile Gly Ile Val Gly Ala Leu Ser His Ala Asn Ser Val Ser Met 50 55 Leu Leu Leu Phe Gly Ala Phe Leu Ser Ile Asn Leu Gly Ile Leu Asn 70 75 Leu Leu Pro Ile Pro Ala Leu Asp Gly Ala Gin Met Leu Gly Val Val 90 Phe Lys Asn Ile Phe His Ile Ala Leu Pro Thr Pro Ile Gln Asn Ala 100 105 110 Leu Trp Leu Val Gly Val Gly Phe Leu Val Phe Val Met Phe Leu Gly 115 120 125 Leu Phe Asn Asp Ile Thr Arg Leu Leu 130 135 INFORMATION FOR SEQ ID NO:555: SEQUENCE CHARACTERISTICS: LENGTH: 124 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .124 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:555 Val Met Ala Leu Leu Lys Ile Ser Val Val Vai Pro Glu Gly 1 Phe Gly Asn Asp Ile Ala Thr Gly Val Trp Gly Ser Val Gly Val1 Val1 Gly Ala Arg Ser 115
S
Giu Val Leu Tyn Glu Ile Tyr Ala Val Phe Ala Lys 100 Ser Val Lys Gly Glu Glu Ile Lys Leu Val1 Ser Glu Thr Lys Leu Lys 120 Val1 Asn Asn Asn Gly Glu 105 Ile Glu Val Gly Giu Gin Ala Ala Ile Leu Ala Asp Ala Arg Leu C C C. C C
C
C
INFORMATION FOR SEQ ID NO:556: SEQUENCE CHARACTERISTICS: LENGTH: 86 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KY misc-feature LOCATION .86 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:556 Tyr Sen Leu Leu Leu Asp Leu Asn Lys Lys -10 *Arg Gly Phe Phe Ile Asp Asp Lys His Ile 25 *Thr Pro Thr Leu Leu Giu Leu Tyr Sen Asp 40 Leu Lys Cys Giu Tyr Phe Ile Met Glu Val 55 *Gin Asn Ala Sen Leu Gly Leu Ile Ser Leu 70 75 Sen Gin Ala Ile Ile Met Thr Arg Val Ile Thr Ala Leu Leu Gly Lys Glu Lys Gly Leu Leu Giu Glu Ala Ile Sen Sen His Ala Ile Leu Lys Phe Ser Pro INFORMATION FOR SEQ ID NO:557: SEQUENCE CHARACTERISTICS: LENGTH: 86 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...86 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:557 Met Ser Lys Arg Ala Ile Arg Phe Pro Asn Lys Leu Phe Ser Tyr Pro 1 5 10 Lys Pro Lys Ile Lys Ala Thr Asn Thr Ser His Thr Val Leu Phe Ala 25 Tyr Pro Leu Lys Pro His Glu Met Ala Leu Leu Ala Leu Ala Thr Ser *35 40 Leu Leu Ala Pro Ile Phe Asn Ala Ile His Ser Thr Asn Ala Leu Asn 50 55 Ala Ile Lys Pro Asp Gly Thr Gly Ser Lys Ile Asn Pro Ile Ile Met 70 75 Pro Met Lys Ile Gln Lys INFORMATION FOR SEQ ID NO:557: SEQUENCE CHARACTERISTICS: LENGTH: 86 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...86 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:557 Met Ser Lys Arg Ala Ile Arg Phe Pro Asn Lys Leu Phe Ser Tyr Pro 1 5 10 Lys Pro Lys Ile Lys Ala Thr Asn Thr Ser His Thr Val Leu Phe Ala 25 Tyr Pro Leu Lys Pro His Glu Met Ala Leu Leu Ala Leu Ala Thr Ser 40 Leu Leu Ala Pro Ile Phe Asn Ala Ile His Ser Thr Asn Ala Leu Asn 55 Ala Ile Lys Pro Asp Gly Thr Gly Ser Lys Ile Asn Pro Ile Ile Met 70 75 Pro Met Lys Ile Gln Lys
I
INFORMATION FOR SEQ ID NO:558: SEQUENCE CHARACTERISTICS: LENGTH: 108 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc -feature LOCATION .108 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:558 Met Lys Thr Asn Phe Tyr Lys Ile Lys Leu Leu 1 5 10 le Ile Gly Met Phe Asn Ala Pro Leu Asn Ala 20 25 le Lys Asp Ile Ser Pro Glu Asp Met Ala Leu 35 40 Val Ser Arg Asp Gin Leu Lys Ile Gu Ile Pro 50 55 Gin Lys Val Thr Ile Leu Asn Asp Tyr Asri Asp 65 70 75 Lys Phe Asp Asp Ile Sen Leu Gly Ser Phe Gin 90 Gly Ile Asn Ala Met Trp Giy Ile Gin Asn Leu 100 105 a. a a. a a a a.
a a Phe Ala Trp Cys Asp Gin Asn Thr Asn Sen Val Giy Lys Giu Thr Leu Lys Asn Vai Asn Pro Asn Asp Asn jeu Leu Asp Leu Glu Ile Leu INFORMATION FOR SEQ ID NO:559: SEQUENCE CHARACTERISTICS: LENGTH: 141 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEy: misc-feature LOCATION I1.. .141 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:559 Val Tyr Ser Arg Phe Phe Ala Asn Gin His Glu Phe Asp Phe Giu Ala 1 5 10 Gin Cly Ala Leu Giy Ser Asp Gin Ser Sen Leu Asn Phe Lys Sen Thr 25 Leu Leu Gin Asp Leu Asn Gin Sen Tyr Asn Tyr Leu Ala Tyr Ser Ala 40 Thr Ala Leu Val Thr Asn Ala Ser Ile Ile Lys Ser 130 Arg Ala Ser Tyr Leu Phe Ser Met 115 Ser Lys
LYS
Gin 100 Gly Leu Pro Ser His Thr Ser 70 Asn Leu Leu C ly 55 Val1 Ser Phe His Phe Ser Gin 90 Asn Ile Met 46 Ala Tyr 75 Val1 Ala Cys Trp .4 Phe As n Ala Thr Met Arg 140 Phe Arg Asn Ala His Leu Gly Ser Leu Lys Asn Gly Trp Lys Arg Vai 110 Trp Glu Phe Tyr 125 Leu Thr Leu Asp 135 INFORMATION FOR SEQ ID NO:559: SEQUENCE CHARACTERISTICS: LENGTH: 141 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .141 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:559 9 9.9 Val Tyr 1 Gin Gly Leu Leu Thx Ala 50 Leu Val Thr Asn Ala Ser Ile Ile Lys Ser 130 Ser Arg Phe 5 Ala Leu Gly 20 Gin Asp Leu Arg Ala Ser Leu Lys Pro Phe Lys Sen 85 Ser Gin His 100 Met Gly Thr 115 Ser Leu Thr Phe Ala Asn Gin His Giu Phe Asp Phe Giu Ala Ser Asn Tyr Ser 70 Asn Leu Leu Leu Asp Gin Gly 55 Val1 Ser Phe His Asp 135 Gin Ser 40 Tyn Gly Gin Asn Thr 120 Ang Ser 25 Tyn Asp Val1 Sen Ala 105 Phe Met Ser Asn Phe Ser Gin 90 Asn Ile Met Leu Tyr Ala Tyr Val Ala Cys Trp Asn Leu Phe Asn Ala Thr Met Arg 140 Phe Ala Phe His Leu Tnp Trp 125 Leu is Ser Asn Gly Asn Ang Phe INF ORMATION FOR SEQ ID NO:560: Wi SEQUENCE CHARACTERISTICS: LENGTH: 231 amino acids TYPE: amino acid TOPOLOGY: linear MOLECULE TYPE: protein HYPOTHETICAL: YES (ii) (iii) 465 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...231 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:560 Met Ile Asp Asn Leu Asp Gly Ala Lys Asp Ala Gin Leu Ile Lys Lys 1 5 10 Ala Tyr Ala Phe Leu Cys Leu Gly Gly Asp Gly Thr Ile Leu Gly Ala 25 Leu Arg Met Thr His Ala His Asn Lys Pro Cys Phe Gly Val Arg Ile 40 Gly Asn Leu Gly Phe Leu Ser Ala Val Glu Leu Asn Gly Leu Lys Asp 55 Phe Leu Gin Asp Leu Lys Gin Asn Arg Ile Lys Leu Glu Glu His Leu 70 75 Ala Leu Glu Gly Arg Ile Gly Asn Thr Ser Phe Tyr Ala Ile Asn Glu 90 Ile Val Ile Ala Lys Lys Lys Ala Leu Gly Val Leu Asp Ile Lys Ala 100 105 110 Cys Ala Gly His Thr Pro Phe Asn Thr Tyr Lys Gly Asp Gly Leu Ile 115 120 125 Ile Ala Thr Pro Leu Gly Ser Thr Ala Tyr Asn Leu Ser Ala His Gly S130 135 140 Pro Ile Val His Ala Leu Ser Gin Ser Tyr Ile Leu Thr Pro Leu Cys 145 150 155 160 Asp Phe Ser Leu Thr Gin Arg Pro Leu Val Leu Gly Ala Glu Phe Cys S* 165 170 175 Leu Ser Phe Cys Ala His Glu Asp Ala Leu Val Val Ile Asp Gly Gin 180 185 190 S Ala Thr Tyr Asp Leu Lys Ala Asn Gin Pro Leu Tyr Ile Gin Lys Ser 195 200 205 Pro Thr Thr Thr Lys Leu Leu Gln Lys Asn Ser Arg Asp Tyr Phe Lys S" 210 215 220 Val Leu Lys Glu Lys Leu Leu S 225 230 INFORMATION FOR SEQ ID NO:561: i) SEQUENCE CHARACTERISTICS: LENGTH: 185 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE:- ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...185 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:561 Met Unk Glu Asn Gly Arg Gly Val Pro Lys Asp Tyr Lys Lys Ala Val 1 5 10 Glu Tyr Phe Gin Lys Ala Val Asp Asn Asp Ile Pro Arg Gly Tyr Asn 25
I
466 Asn Leu Gly Val Met Tyr Lys Glu Gly Lys Gly Val Pro Lys Asp Glu 40 Lys Lys Ala Val Glu Tyr Phe Arg Ile Ala Thr Glu Lys Gly Tyr Thr 55 Asn Ala Tyr Ile Asn Leu Gly Ile Met Tyr Met Glu Gly Arg Gly Val 70 75 Pro Ser Asn Tyr Ala Lys Ala Thr Glu Cys Phe Arg Lys Ala Met His 90 Lys Gly Asn Val Unk Ala Tyr Ile Leu Leu Gly Asp Ile Tyr Tyr Ser 100 105 110 Gly Met Ile Asn Trp Val Leu Ser Arg Thr Lys Ile Arg Leu Val His 115 120 125 Tyr Lys Met Ala Ala Asp Val Ser Ser Ser Arg Ala Tyr Unk Gly Leu 130 135 140 Ser Glu Ser Tyr Unk Tyr Gly Leu Gly Val Glu Lys Unk Unk Lys Lys 145 150 155 160 Ala Glu Glu Tyr Met Gin Lys Ala Cys Asp Phe Asp Ile Asp Lys Asn 165 170 175 Cys Lys Lys Lys Asn Thr Ser Ser Arg 180 185 INFORMATION FOR SEQ ID NO:561: SEQUENCE CHARACTERISTICS: LENGTH: 185 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...185 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:561 Met Unk Glu Asn Gly Arg Gly Val Pro Lys Asp Tyr Lys Lys Ala Val 1 5 10 Glu Tyr Phe Gin Lys Ala Val Asp Asn Asp Ile Pro Arg Gly Tyr Asn S. 20 25 SAsn Leu Gly Val Met Tyr Lys Glu Gly Lys Gly Val Pro Lys Asp Glu 40 Lys Lys Ala Val Glu Tyr Phe Arg Ile Ala Thr Glu Lys Gly Tyr Thr 55 Asn Ala Tyr Ile Asn Leu Gly Ile Met Tyr Met Glu Gly Arg Gly Val 70 75 Pro Ser Asn Tyr Ala Lys Ala Thr Glu Cys Phe Arg Lys Ala Met His 90 Lys Gly Asn Val Unk Ala Tyr Ile Leu Leu Gly Asp Ile Tyr Tyr Ser 100 105 110 Gly Met Ile Asn Trp Val Leu Ser Arg Thr Lys Ile Arg Leu Val His 115 120 125 Tyr Lys Met Ala Ala Asp Val Ser Ser Ser Arg Ala Tyr Unk Gly Leu 130 135 140 Ser Glu Ser Tyr Unk Tyr Gly Leu Gly Val Glu Lys Unk Unk Lys Lys 145 150 155 160 Ala Glu Glu Tyr Met Gin Lys Ala Cys Asp Phe Asp Ile Asp Lys Asn 165 170 175 Cys Lys Lys Lys Asn Thr Ser Ser Arg I 180 185 INFORMATION FOR SEQ ID NO:562: SEQUENCE CHARACTERISTICS: LENGTH: 183 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...183 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:562 Met Ile Val Gly Leu Ile Gly Val Val Glu Lys Ile Ser Ala Leu Glu 1 5 10 Ala His Ile Glu Val Gin Gly Val Val Tyr Gly Val Gin Val Ser Met 20 25 Arg Thr Ala Ala Leu Leu Gin Thr Gly Gin Lys Ala Arg Leu Lys Ile 40 Leu Gin Val Ile Lys Glu Asp Ala His Leu Leu Tyr Gly Phe Leu Glu 55 Glu Ser Glu Lys Ile Leu Phe Glu Arg Leu Leu Lys Ile Asn Gly Val 65 70 75 S Gly Gly Arg Ile Ala Leu Ala Ile Leu Ser Ser Phe Ser Pro Asn Glu 90 Phe Glu Asn Ile Ile Ala Thr Lys Glu Val Lys Arg Leu Gin Gin Val 1* 00 105 110 Pro Gly Ile Gly Lys Lys Leu Ala Asp Lys Ile Met Val Asp Leu Ile S* 115 120 125 Gly Phe Phe Ile Gin Asp Glu Asn Arg Pro Ala'Arg Asn Glu Val Phe S130 135 140 Leu Ala Leu Glu Ser Leu Gly Phe Lys Ser Ala Glu Ile Asn Pro Val 145 150 155 160 Leu Lys Thr Leu Lys Pro His Leu Ser Ile Glu Ala Ala Ile Lys Glu 165 170 175 Ala Leu Gin Gin Leu Arg Ser 180 INFORMATION FOR SEQ ID NO:563: SEQUENCE CHARACTERISTICS: LENGTH: 154 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .154 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:563 Val Gly Val Leu Leu Ala Leu Phe Phe Phe Tyr Ala Lys Asn Asn Leu 1 Leu Lys Ile Asp
LYS
Gly Lys Tyr Leu 145 Asn Leu Glu Arg Asp Ile 115 Met Ala Gln Glu Arg Lys Leu Thr Ala Gly Trp Met As n Asn Asn Thr Ala Glu 120 Phe Lys Ser Pro Gly Tyr Thr Gln G ly Pro INFORMATION FOR SEQ ID NO:564: SEQUENCE CHARACTERISTICS: LENGTH: 288 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .288 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:564
S
Val Val Ile Met Ile Leu Val Cys Phe Leu Ala Cys 1 Phe Ile Lys Arg Ile Phe Phe Phe Ser Val Leu Sen Sen Gin Pro Lys 130 Lys Pro Leu Gin Ile Tyr Lys 115 Leu Met Ser Gin Leu Leu Pro 100 Asn Ile Gin Tyr Asn Thr Leu Asn Pro Glu Lys Asp Val1 Asp Giu Pro Leu Sen Ala Ser 40 Tyr G iu Pro Asn Tyr 120 Gin Glu Tyr Pro Asn Asp Asn Pro Asp Ser Asn Phe Giu Asn Glu Asn Lys 125 Pro 135 Gly Asp Ile Ile Met, Sen Lys Giu Gly Asp Gin Trp Leu Ile Giu Ile 145 150 155 160 Gin Ser Lys Ala Leu Lys Arg Phe Leu Lys Asp Gin Asn Asp Lys Asp 165 170 175 Arg Gin Ile Gin Thr Phe Thr Phe Asn Asp Thr Lys Thr Gin Ile Ala 180 185 190 Gin Ile Lys Gly Lys Ile Ser Ser Tyr Val Tyr Thr Thr Asn Asn Gly 195 200 205 Ser Leu Ser Leu Arg Pro Phe Tyr Glu Ser Phe Leu Leu Glu Lys Lys 210 215 220 Ser Asp Asn Val Tyr Thr Ile Glu Asn Lys Ala-Leu Asp Thr Met Glu 225 230 235 240 Ile Ser Lys Cys Gin Met Val Leu Lys Lys His Ser Thr Asp Lys Leu 245 250 255 Asp Ser Gin His Lys Ala Ile Ser Ile Asp Leu Asp Phe Lys Lys Glu 260 265 270 Arg Phe Lys Ser Asp Thr Glu Leu Phe Leu Glu Cys Leu Lys Glu Ser 275 280 285 INFORMATION FOR SEQ ID NO:565: SEQUENCE CHARACTERISTICS: LENGTH: 420 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...420 (xi) SEQUENCE DESCRIPTION: SEQ ID N0:565 Met Ala Ala Pro Leu Leu Ala Leu Pro Phe Leu Ser Asn Pro Leu Val S1 5 10 Leu Gly Ala Leu Ala Val Ile Gly Val Gly Ala Tyr Leu Tyr Pro Asn 25 Lys Gin Asp Ser Leu Val Val Gin Ala Asp Gly Leu Tyr Ser Glu Ile 40 Leu Gly Phe Phe Ile Ser Phe Ser Ser Lys Ile Leu Lys Gly Ile Gly 55 Glu Pro Leu Ala Asn Val Ile Gin Pro Phe Gly Met Val Leu Gly Met 70 75 Leu Leu Ile Leu Leu Tyr Ser Phe Lys Arg Tyr Gin Asn Asn Asp Leu 90 Phe Glu Ile Lys Thr Phe Leu Met Leu Phe Val Phe Val Gly Tyr Leu 100 105 110 Ser Leu Tyr His Tyr Ala Phe Lys Ser Asp Gly Ser Ser Ser Gly Asn 115 120 125 Gly Arg Ser Ser Phe Ala Phe Gin Asn His Val Thr Glu Ile Phe Asp 130 135 140 Thr Pro Ala Asn Leu Leu Asn Ala Gly Ile Ser Asn Val Val Lys Glu 145 150 155 160 Tyr Gin Thr Asn Ser Ala Arg Glu His Lys Asn Ile Asp Thr His His 165 170 175 Ser Ile Thr Asn Ala Asn Ile Ser Phe His Val Arg Gin Ile Leu Thr 180 185 190 Ser Leu Asn Lys Leu Tyr Glu Asp Phe Lys Ile Asn Asn Gly Leu Ser 195 200 205 Leu Lys Thr Leu Ile Ala Ala Val Leu Leu Leu Val Ile Leu Gly Leu 210 215 220 Giu Leu Phe Leu Leu Phe Lys Val Phe Cys Tyr Val Phe Met Thr Tyr 225 230 235 240 Leu Glu Lys Ile Ile Tyr Leu Ser Leu Val Ile Phe Met Leu Leu Leu 245 250 2S55 Gly Phe Phe Gin Gin Thr Arg Giy Phe Leu Val Ser Tyr Val Lys Lys 260 265 270 Ile Ile Ser Leu Thr Phe Tyr Met Pro Leu Leu Leu Leu Leu Val Leu 275 280 285 Phe Asn Ser Phe Ala Leu Gin Tyr Ala Ile Lys Val Gly Gly Ser Asn 290 295 300 Giu Ile Val Ala Lys Phe Gly Ile Ile Val Ala Ile Gly Ile Ser Leu 305 310 315 320 Thr Phe Ile Gin Lys Val Pro Giu Met Ile Asn Ala Ile Phe Gly Thr 325 330 335 Gin Gly Gly Leu Thr Asp Ala Lys Ser Phe Ile Tyr Gin Giy Val Gin 340 345 350 Met Ala Ser Ala Gly Ala Gly Ala Ile Ala Gly Ser Leu Lys Ser Val 355 360 365 Giy Arg Ser Ala Phe Gly Arg Thr Leu Glu Ala Tyr Lys Asp Ala Lys 370 375 380 Ser Thr Ile Asn Ser Thr Thr Ala Asn Met Arg Asp Met Pro Gly His 385 390 395 400 Pro Gly Val Arg Val Gly Val Giu Thr Ile Giu Leu Pro Lys Ser His AgAaSrLs405 410 415 420 INFORMATION FOR SEQ ID NO:566: SEQUENCE CHARACTERISTICS: LENGTH: 72 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICALI: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .72 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:566 Val Leu Lys Phe Gin Lys Leu Pro Leu Leu Phe Val Ser Ile Leu Tyr 1 5 -10 is Asn Gin Sen Pro Leu Leu Ala Phe Asp Tyr Lys Phe Sen Gly Val Ala 25 Giu Sen Val Ser Lys Val Giy Phe Asn His Sen Lys Leu Asn Ser Lys 40 Glu Gly Ile Phe Pro Thr Ala Thr Phe Val Thr Ala Thr Ile Lys Leu 55 Gin Val Asn Tyr Lys Sen Ala Pro INFORMATION FOR SEQ ID NO:567: SEQUENCE CHARACTERISTICS: LENGTH: 205 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...205 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:567 Met Gly Asn His Phe Ser Lys Leu Gly Phe Val Leu Ala Ala Leu Gly 1 5 10 Ser Ala Ile Gly Leu Gly His Ile Trp Arg Phe Pro Tyr Met Thr Gly 25 Val Ser Gly Gly Gly Ala Phe Val Leu Leu Phe Leu Phe Leu Ser Leu 40 Ser Val Gly Ala Ala Met Phe Ile Ala Glu Met Leu Leu Gly Gin Ser 55 Thr Gin Lys Asn Val Thr Glu Ala Phe Lys Glu Leu Asp Ile Asn Pro 65 70 75 Lys Lys Arg Trp Lys Tyr Ala Gly Ile Met Leu Ile Ser Gly Pro Leu 85 90 Ile Leu Thr Phe Tyr Gly Thr Ile Leu Gly Trp Val Leu Tyr Tyr Leu 100 105 110 Val Ser Ile Ser Phe Asn Leu Pro Ser Ser Ile Gin Glu Ser Glu Gin 115 120 125 Ile Phe Thr Gin Thr Leu Gin Ser Ile Gly Leu Gin Ser Ile Gly Leu 130 135 140 Phe Ser Val Leu Phe Ile Thr Gly Trp Ile Val Ser Arg Gly Ile Lys 145 150 155 160 Glu Gly Ile Glu Lys Leu Asn Leu Val Leu Met Pro Leu Leu Phe Ala 165 170 175 Thr Phe Phe Gly Leu Leu Phe Tyr Ala Met Ser Met Asp Ser Phe Ser 180 185 190 Lys Ala Phe His Phe Met Leu Ile Ser Ser Gin Lys Ile 195 200 205 INFORMATION FOR SEQ ID NO:568: SEQUENCE CHARACTERISTICS: LENGTH: 328 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...328 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:568 1Met Glu Lys Val Cys Val Ser Ala Trp Gly Leu Pro Lys Ile Leu Giu Giu Ala Ala Leu Leu
LYS
Ala
LYS
Ile 145 Arg Ile Ala Ser Ile 225 Leu Met Leu Ala Val 305 Gin Arg
LYS
Lys Lys Phe Ile Leu Val 130 Val Gin Lys Phe Ile 210 Ala Phe Thr Asn Ile 290 Lys Tyr Leu Ala Giu Lys Asp Gly Ile 115 Pro Gin Leu Giu Giu 195 Tyr Leu His Phe Pro 275 Leu Ser Lys Lys Ile Gin Val1 Giu Asp 100 Giu Arg Val1 Gin 180 Val1 Thr Ile Lys Giu 260 Thr Lys Arg Asp Giu Asn Gin Gly Val1 Trp Ala Leu Ala Ala 165 Asn Trp Asn Ser Giu 245 Phe Gly Asp Ile Val1 325 Asp Trp Giu Giu Giu Lys Asp Met 75 Val Leu 90 Ala Val Cys Leu Asn Ala Arg Ala 155 Asn Arg 170 Giu Thr Lys Leu Arg Lys Asn Ile 235 Giu Lys 250 Ile Asp Gly Tyr Asn Lys Lys Lys 315 Lys Val1 Leu Gin Gin Phe Pro 125 Gin Gin Asn Arg Ser 205 Ser Ile Tyr Lys Val1 285 Lys His Lys Asn Ser Ala Phe 110 Leu Asn Ala Ile Leu 190 Ile Ser Arg Ser 270 Thr Asp Val Ala Gly Thr G iu Ala Lys Phe Leu S er 175 Gin Giu Ile Ala Ile 255 Val G iu Asp Lys Lys Phe Met Arg Leu Giu Ala Val1 160 Ser Ser His Asn Gin 240 Ile Pro Ile Gly S. S
S
S
Asp Pro His Met Ser INFORMATION FOR SEQ ID NO:569: SEQUENCE CHARACTERISTICS: LENGTH: 139 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .139 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:569 Leu Leu Asn Met Trp Asp Giu Ala Lys Lys Giu Gly Ile Asn Ile Asn
I
Thr Ala Ile Vai Gin Phe Trp Leu Giu Lys Leu Arg Unk Lys Vai Arg Leu Pro Ser Gin Arg Ile Ala Glu His Thr 100 Asp Phe His 11s Phe Asn Arg 130 5 Ser Glu Tyr Ser Lys 85 Tyr Phe Arg Gln Asp Ser Phe 70 Ser Lys Phe G iy Giu Arg Gin 55 Lys Val Ile Unk Ser 135 Leu Leu 40 As n G iu Ile Asp Val 120 Ala 10 Giy Val 2S Asn Thr Thr Thr Ser Leu Ser Giu 90 Lys Ile *105 Tyr Val *Lys Ser Val Cys Val Pro Giu Leu Leu Leu Asn Asn Glu Asn Lys Tyr Ser Gin 75 Asn Lys Gin Asn Phe Asn Ala Pro 110 Tyr His Leu Phe 125 Pro i5 Thr Ser Asp Giu Ile Lys Ser Ala Ala Ser Ala Leu Phe Giu
C
em me..
.me.
em em em m INFORMATION FOR SEQ ID NO:569: Ci) SEQUENCE
CHARACTERISTICS:
LENGTH: 139 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .139 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:569 Leu Leu Asn Met Trp Asp Glu Ala Lys Lys Gia Gly Ile Asn Ile Asn 1 5 10 Thr Glu Lys Leu Ser Gin Glu Leu Gly Val Val Cys Val Pro Thr Ser 25 Ala Arg Unk Lys Giu Asp Arg Leu Asn Thr Glu Leu Leu Leu Asp Glu 35 40 Ile Val Arg Leu Tyr Ser Gin Asn Thr Thr Asn Asn Giu Asn Ile Lys 55 Vai Pro Ser Gin Ser Phe Lys Giu Ser Leu Lys Tyr Ser Gin Ser Ala 70 75 Gin Arg Ile Ala Lys Ser Val Ile Ser Giu Asn Lys Gin Asn Ala Ser as 90 Phe Giu His Thr Tyr LysIle Asp Lys Ile Phe Asn Ala Pro Ala Leu 100 105 110 Trp Asp Phe His Phe Phe Unk Val Tyr Vai Tyr His Leu Phe Phe Giu 115 120 125 Leu Phe Asn Arg Arg Gly Ser Ala Lys Ser Pro 130 135 em C mine INFORMATION FOR SEQ ID NO:570: SEQUENCE
CHARACTERISTICS:
LENGTH: 76 amino acids JB) TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .76 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:570 Leu His Lys Ala Lys Val Gly Ile Val Phe 10 Phe Cys Val Phe Leu Leu Leu Phe Tyr Leu 25 Ala Phe Lys Asp Thr Lys Arg Met Phe Ile 40 Val Val Phe Leu Trp Ser Asp Leu Leu Val Ile Sen Phe Val Leu Asp Ile Gly Tyr Giu 70 Met Ile Val1 Sen Asn 31n Ala Leu Leu Gly Ser Ala Phe Leu Met Ser Val Leu Ile Gly Phe Val Gly Phe Lys I le
U
U.
U
U
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INFORMATION FOR SEQ ID NO:571: SEQUENCE CHARACTERISTICS: LENGTH: 193 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .193 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:57i Met Gin Giu Ala Leu Leu 1 Val Ile Leu Gin Tyr Ser Phe Gly Leu Ser Leu Phe Arg Leu 100 Pro Leu Sen 5 Phe Ile Val1 Ala Arg Met Leu Asn Phe, Leu Leu Ala Ang 70 Lys Ile Ala Val Gin Arg Tyr Ser Phe Ty'r Leu Phe Ile Phe 135 Ala Phe Gin Giu Gly Ser Ala Leu Gin Ala Val Giy 120 Sen Sen Leu Thr Gly Lys Leu Asn 105 Phe Sen Asp 10 Gly Thr Asn Arg Ala 90 Lys Ser Phe Trp Gly His Leu Glu Ser Tyr Lys Leu Val Phe Gly Ala Ile Phe Leu Leu Tyr Trp 140 Lys Lys Tyr Leu Gly Leu Trp Pro 125 Ala Thr Trp is Gly Ile Gly Tyr Lys Ile Lys Ile Tyr 145 iso 155 160 Arg Leu Ser His Tyr Thr Ser Phe Phe Val Ile Ser Phe Val Leu Ile 165 170 175 Ala Leu Leu Ile Trp Phe Leu Leu Lys Arg T'yr Ser Arg Lys Met Gly 180 185 190 Phe INFORMATION FOR SEQ ID NO:571: SEQUENCE CHARACTERISTICS: LENGTH: 193 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NME/KEY: misc-fieature LOCATION 1 193 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:571 Met Gin Glu Ala Leu Leu Arg Phe Gin Glu Gly Phe Lys Glu Trp Giy 1 5 10 Tyr Leu Ile Leu Phe Leu Tyr Ser Leu Gly Gly Giy Tyr Vai Gly Ile 25 Val Ile Ala Sen Ile Leu Ser Ala Thr Thr His Ala Leu Asp Ile Lys 40 le Thr Ile Leu Val Ala Phe Leu Gly Asn Leu Ile Gly Ser Gly Ala .9.50 55 Leu Val Ile Phe Ala Arg Tyr Gin Lys Arg Glu Phe Leu Lys Tyr Phe 70 75 Gin Lys His Arg Arg Lys Leu Ala Leu Ala Ser'Leu Trp Val Lys Arg *.85 90 Tyr Ala Leu Leu Met Ile Phe Val Asn Lys Tyr Leu Tyr Gly Ile Lys .9.100 105 110 Ser Val Val Pro Leu Ala Ile Giy Phe Ser Lys Tyr Pro Leu Lys Lys 115 120 125 Phe Leu Trp, Leu Asri Val Phe Sen Sen Phe Leu Trp Ala Leu Ile Val 130 135 140 Gly Ser Val Ser Phe Gin Ala Sen Asp Trp Val Lys Thr Leu Tyr Giu 145 150 155 160 Arg Leu Ser His Tyr Thr Ser Phe Phe Val Ile Ser Phe Val Leu Ile 165 170 175 Ala Leu Leu Ile Trp Phe Leu Leu Lys Arg Tyr Sen Arg Lys Met Gly 180 -185 190 Phe INFORMATION FOR SEQ ID NO:572: SEQUENCE CHARACTERISTICS: LENGTH: 140 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .140 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:572 Met Pro Phe Leu Lys Asn Trp Ile Trp Ser Leu Lys Met Ala Leu Ser 1 5 10 Ala Ile Ser Gly Ala Ser Gly Vai Gly Lys Ser Val Leu Ile Ala Ser 25 Leu Leu Gly Ala Phe Gly Leu Lys Glu Ser Asn Ala Ser Asn Ile Giu 40 Val Glu Leu Ile Ala Pro Phe Leu Asp Thr Glu Giu Tyr Gly Ile Phe 55 Arg Giu Asp Giu His Glu Pro Leu Val Ile Ser Val Ile Lys Lys Giu 70 75 Lys Thr Arg Tyr Phe Leu Asn Gln Thn Sen Leu Ser Lys Asn Thr Leu 90 *Lys Ala Leu Leu Lys Gly Leu Ile Lys Arg Leu Ser Asn Asp Arg Phe 100 105 110 Sen Gln Asn Glu Leu Asn Asp Ile Leu Met Leu Ser Leu Leu Asp Gly yrie115 120 125 TrIeGin Asn Lys Asn Lys Arg Leu Ala Pro Phe *130 135 140 INFORMATION FOR SEQ ID NO:573: SEQUENCE CHARACTERISTICS: WA LENGTH: 308 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .308 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:573 Met Pro Gin Asn Gin Leu Val Ile Thr Ile Ile Asp Glu Sen Gly Ser 1 5 10 Lys Gin Leu Lys Phe Ser Lys Asn Leu Lys Arg Asn Leu Ile Ile Sen 25 Val Val Ile Leu Leu Leu Ile Val Gly Leu Gly Val Giy Phe Leu Lys 40 Phe Leu Ile Ala Lys Met Asp Thr Met Thr Ser Giu Arg Asn Ala Val so 55 Leu Arg Asp Phe Arg Giy Leu Tyr Gin Lys Asn Tyr Ala Leu Ala Lys 70 75 Giu Ile Lys Asn Lys Arg Giu Glu Leu Phe Ile Val Giy Gin Lys Ile 90 Arg dly Leu Giu Ser Leu Ile Glu Ile Lys Lys Giy Ala Asn Gly Gly 100 105 110 Gly His Leu Tyr Asp Glu Val Asp Leu Glu Asn Leu Ser Leu Asn Gin 115 120 125 Lys His Leu Ala Leu Met Leu Ile Pro Asn Gly Met Pro Leu Lys Thr 130 135 140 Tyr Ser Ala Ile Lys Pro Thr Lys Glu Arg Asn His Pro Ile Lys Lys 145 150 155 160 Ile Lys Gly Val Glu Ser Gly Ile Asp Phe Ile Ala Pro Leu Asn Thr 165 170 175 Pro Val Tyr Ala Ser Ala Asp Gly Ile Val Asp Phe Val Lys Thr Arg 180 185 190 Ser Asn Ala Gly Tyr Gly Asn Leu Val Arg Ile Glu His Ala Phe Gly 195 200 205 Phe Ser Ser Ile Tyr Thr His Leu Asp His Val Asn Val Gin Pro Lys 210 215 220 Ser Phe Ile Gin Lys Gly Gin Leu Ile Gly Tyr Ser Gly Lys Ser Gly 225 230 235 240 Asn Ser Gly Gly Glu Lys Leu His Tyr Glu Val Arg Phe Leu Gly Lys 245 250 255 Ile Leu Asp Ala Glu Lys Phe Leu Ala Trp Asp Leu Asp His Phe Gin 260 265 270 Ser Ala Leu Glu Glu Asn Lys Phe Ile Glu Trp Lys Asn Leu Phe Trp 275 280 285 Val Leu Glu Asp Ile Val Gin Leu Gin Glu His Val Asp Lys Asp Thr 290 295 300 Leu Lys Gly Gin 305 9* 0* INFORMATION FOR SEQ ID NO:574: SEQUENCE CHARACTERISTICS: LENGTH: 339 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...339 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:574 Met Ile Thr Gly Ser His Asn Pro Lys Glu Tyr Asn Gly Phe Lys Ile 1 5 10 Thr Leu Asn Gin Asn Pro Phe Tyr Gly Lys Asp Ile Gin Ala Leu Lys 25 Asn Thr Leu Leu Asn Ala Lys His Glu Ile Lys Pro Leu Lys Glu Thr 40 Pro Glu Lys Val Asn Ala Leu Glu Ala Tyr His Arg Tyr Leu Ile Lys 55 Asp Phe Lys His Leu Lys Asn Leu Lys Tyr Lys Ile Ala Leu Asp Phe 70 75 Gly Asn Gly Val Gly Ala Leu Gly Leu Glu Pro Ile Leu Lys Ala Leu 90 Asn Ile Asp Phe Ser Ser Leu Tyr Ser Asp Pro Asp Gly Asp Phe Pro 100 105 110 Asn His His Pro Asp Pro Ser Glu Ala Lys Asn Leu Lys Asp Leu Glu 115 120 125 Lys His Met Arg Glu Asn Ala Ile Leu Ile Gly Phe Ala Phe Asp Gly 130 135 140 Asp Ala Asp Arg Ile Ala Met Leu Ser Ser His His Ile Tyr Ala Gly 145 150 155 160 Asp Glu Leu Ala Ile Leu Phe Ala Lys Arg Leu His Ala Gin Gly Ile 165 170 175 Thr Pro Phe Val Ile Gly Glu Val Lys Cys Ser Gin Val Met Tyr Asn 180 185 190 Ala Ile Asn Thr Phe Gly Lys Thr Leu Met Tyr Lys Thr Gly His Ser 195 200 205 Asn Leu Lys Ile Lys Leu Lys Glu Thr Asn Ala His Phe Ala Ala Glu 210 215 220 Met Ser Gly His Ile Phe Phe Lys Glu Arg Tyr Phe Gly Tyr Asp Asp 225 230 235 240 Ala Leu Tyr Ala Cys Leu Arg Ala Leu Glu Leu Leu Leu Glu Gin Ser 245 250 255 Pro Ser Asp Leu Glu Asn Thr Ile Lys Asn Leu Pro Tyr Ser Tyr Thr 260 265 270 Thr Pro Glu Glu Lys Ile Ala Val Ser Glu Glu Glu Lys Phe Glu Ile 275 280 285 Ile Arg Asn Leu Gin Glu Ala Leu Lys Asn Pro Pro Ser His Phe Pro 290 295 300 Thr Ile Lys Glu Ile Ile Ser Ile Asp Gly Val Arg Val Val Phe Glu 305 310 315 320 His Gly Phe Gly Leu Ile Arg Ala Ser Asn Thr His Pro Leu Phe Ser 325 330 335 INFORMATION FOR SEQ ID NO:575: SEQUENCE CHARACTERISTICS: LENGTH: 207 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...207 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:575 Met Ser Lys Asn Leu Gin Lys Lys Asn Pro Lys Lys Ser Unk Pro Gin 1 5 10 Ala Gin Lys Ala Ile Arg Glu Met Lys Met Phe Glu Thr Ile Ala Phe 25 Tyr Phe Phe Ala Ile Leu Thr Leu Ser Met Ala Leu Val Val Ile Thr 40 Thr Thr Asn Ile Leu Tyr Ala Ile Thr Ala Leu Ala Ser Ser Met Val 55 Phe Ile Ser Ala Phe Phe Phe Leu Leu Asp Ala Glu Phe Leu Gly Val 70 75 Val Gin Ile Thr Val Tyr Val Gly Ala Val Ile Val Met Tyr Ala Phe 90 Gly Met Met Phe Phe Asn Ser Ala Ala Glu Val Val Glu Arg Lys Gin 100 105 110 Ser Pro Lys Ile Leu. Cys Val Leu Ser Phe Gly Val Ala Leu Leu Leu Thr Val 145 Gly Leu Lys 115 120 Leu Ile Leu Ser Ala Pro Ser Ile Unk Glu 130 135 Asn Ser Asn Ala Ile Asp Ala Gin Unk Pro 150 155 Tyr Val Leu Phe Thr Asn Tyr Leu Ile Pro 165 170 Met Leu Leu Val Ala Met Val Gly Gly Ile 180 185 Ile His Gly Lys Asn His Thr Gin Phe Ile 195 200 125 Leu Ser Lys Gin Ile Lys Ala Ile 160 Glu Ala Ala Ala 175 Thr Gly Ile Gin 190 Glu Ser Leu 205 INFORMATION FOR SEQ ID NO:576: SEQUENCE CHARACTERISTICS: LENGTH: 251 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...251 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:576 Met Gly Ala Ile Leu Ser Ile Leu Lys Leu Glu Ile *5 S S S
S
S. S
S.
S So S 1 Thr Leu Tyr Ala 65 lie Leu Ile Asn Leu 145 Glu Met Gin Ile Thr 225 Arg Thr Leu 35 Asn Phe Leu Leu Ile 115 Lys Cys Ser Cys Phe 195 Ala Phe Leu Ser Leu Asn Gly Phe Ile 100 Val Ala Phe Ile Asn 180 Ile Phe Ile Leu Ala Ile Ile Leu Tyr Ala Leu Leu Cys Leu 165 Val Lys Gin Ile Thr 245 Phe Val Gly Gin Leu Arg Phe Leu 135 Ala Phe Val Ser Ile 215 Gly Lys Trp Phe 40 Leu Ala Ser Leu Tyr 120 Gly Ile Cys Pro Ile 200 Asp Ile Glu Lys Pro Thr Ile Arg Lys Leu Ile 125 Phe Ile Leu Pro Asn 205 Leu Leu Leu Met Phe' Ser Asn Thr Phe Leu Ala Asn 160 Leu Gly Leu Ser Asn 240 C C
.D
CC..
C C C.
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C.
CC
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OC C SC. INFORMATION FOR SEQ ID NO:577: SEQUENCE CHARACTERISTICS: LENGTH: 69 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...69 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:577 Met Ala Gly Thr Gin Ala Ile Tyr Glu Ser Ser S 1 5 10 Ser Gin Val Ser Ser Ile Ile Ser Ser Thr Ser G 20 25 Phe Ala Gly Ile Val Ala Gly Ala Met Thr Ala A 40 Val Val Gly Phe Thr Asn Pro Gin Met Thr Asp I 50 55 6 Lys Ser Lys His Arg INFORMATION FOR SEQ ID NO:578: SEQUENCE CHARACTERISTICS: LENGTH: 112 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...112 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:578 Val Ser Arg Ile Leu Gly Leu Ser Asp Asp Leu 1 5 Ala Glu Ser Ile Arg Ile Gin Ala Pro Ile Lys 25 Gly Ile Glu Ile Pro Asn Ser Gin Ser Gin Ile Ile Leu Glu Ser Glu Leu Phe Gin Lys Ser Ser 55 Ala Leu Gly Lys Asp Ile Val Gly Asn Pro Phe 70 75 Lys Leu Pro His Leu Leu Ile Ala Gly Thr Thr er Ala Gly Phe Leu ly Val Ala Gly Pro la Ile Ile Pro Ile le Ile Asn Pro Ile 0 Ala Gly lie Ser Ile Gly Thr Asp Leu Leu Asp Gly Cys Val Glu Leu Lys Ser 90 Val Gly Val Asn Ala Met Ile Leu Ser Leu Leu Tyr Lys Lys Pro Pro 100 105 110 INFORMATION FOR SEQ ID N0:579: SEQUENCE CHARACTERISTICS: LENGTH: 152 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...152 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:579 Met Asp Glu Unk Leu Val Tyr Gly Val Ile Cys Met Pro Ser Gin Val 1 5 10 Phe Ala Asn Thr Gly Thr Asn Val Ser Ile Ile Phe Phe Gin Lys Thr 20 25 Pro Ser Ala Lys Glu Val Ile Leu Ile Asp Ala Ser Lys Leu Gly Glu 40 Glu Tyr Thr Glu Asn Lys Asn Lys Lys Thr Arg Leu Arg Pro Ser Asp 55 Met Asp Leu Ile Leu Glu Thr Phe Gin Asn Lys Ala Pro Lys Ser Asp 65 70 75 Phe Cys Ala Leu Val Ser Phe Asp Glu Ile Thr Glu Lys Asn Tyr Ser 85 90 Leu Asn Pro Gly Gln Tyr Phe Thr Ile Glu Asp Thr Ser Glu Thr Ile 100 105 110 Ser Gin Ala Glu Phe Glu Asn Leu Met Gin Gln Tyr Ser Ser Glu Leu 115 120 125 Ala Ser Leu Phe Asp Glu Ser Gin Asn Leu Gin Gin Glu Ile Leu Glu 130 135 140 Thr Leu Lys Gly Val Arg Phe Glu 145 150 INFORMATION FOR SEQ ID NO:580: SEQUENCE CHARACTERISTICS: LENGTH: 129 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...129 482 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:580 Met Arg Lys Gly Arg Val Met Leu Cys Val Phe Asp Ile Glu Thr Ile 1 5 10 Pro Asn Ile Ser Leu Cys Lys Glu His Phe Gin Leu Lys Glu Asp Asp 25 Ala Leu Lys Ile Cys Glu Trp Ser Phe Glu Lys Gin Lys Glu Lys Ser 40 Gly Ser Glu Phe Leu Pro Leu Tyr Leu His Glu Ile Ile Ser Ile Ala 55 Ala Val Ile Gly Asp Asp Tyr Gly Gin Phe Ile Lys Val Gly Asn Phe 70 75 Gly Gin Lys His Glu Asn Lys Glu Asp Phe Ala Ser Glu Lys Glu Leu 90 Leu Glu Asp Phe Phe Lys Tyr Phe Asn Glu Lys Gin Pro Arg Leu Ile 100 105 110 Ser Phe Unk Gly Arg Gly Phe Gly Tyr Ser Pro Thr His Ala Gln Ser 115 120 125 Pro INFORMATION FOR SEQ ID NO:580: SEQUENCE CHARACTERISTICS: LENGTH: 129 amino acids TYPE: amino acid TOPOLOGY: linear 0:0% (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: S 0 ORGANISM: Helicobacter pylori S(ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...129 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:580 S Met Arg Lys Gly Arg Val Met Leu Cys Val Phe Asp Ile Glu Thr Ile 1 5 10 Pro Asn Ile Ser Leu Cys Lys Glu His Phe Gin Leu Lys Glu Asp Asp 25 OAla Leu Lys Ile Cys Glu Trp Ser Phe Glu Lys Gin Lys Glu Lys Ser 40 Gly Ser Glu Phe Leu Pro Leu Tyr Leu His Glu Ile Ile Ser Ile Ala 55 Ala Val Ile Gly Asp Asp Tyr Gly Gin Phe Ile Lys Val Gly Asn Phe 70 75 Gly Gin Lys His Glu Asn Lys Glu Asp Phe Ala Ser Glu Lys Glu Leu 90 Leu Glu Asp Phe Phe Lys Tyr Phe Asn Glu Lys Gin Pro Arg Leu Ile 100 105 110 Ser Phe Unk Gly Arg Gly Phe Gly Tyr Ser Pro Thr His Ala Gin Ser 115 120 125 Pro INFORMATION FOR SEQ ID NO:581: SEQUENCE CHARACTERISTICS: 483 Met Val Asn Asn Git 65 Ile Th2 As; LENGTH: 113 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .113 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:581 *Arg Ang Ile Ile Lys Asn Thn Leu Ser Ang 10 *Leu Glu Ala Giu His Giy Val Giu Ala Trp 25 Ala Asp Thr Lys Val Leu Ile Thn Asp Trp 40 Gly Leu Asp Leu Val Lys Lys Val Arg Ala 55 Ile Pro Ile Ile Met Ile Thr Thr Giu Giy 70 75 Thr Thr Leo Lys Ala Gly Vai A-sn Asn Tyn 85 90 *Pro Gin Val Leu Lys Gbu Lys Leo Giu Vai 100 105 Leu Glu Asn Asp Gly Ile Val Gly Lys Met Asn Lys Val Leu Tyr Leu Pro Arg Ala Lys Gly 110 Giu Asp Asp Ala Glb Met Phe Lys Glu Vai Pro Phe Thr Asn a a a.
a a INFORMATION FOR SEQ ID NO:582: SEQUENCE CHARACTERISTICS: LENGTH: 174 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 174 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:582 Met Ala Glu Glu Gin Glu Asn Thr Ala Gin Gin Pro Gin Lys Lys 1 5 10 is Lys Ala Leo Leo Phe Val Ile Ile Gly Sen Val Leu Val Met Leu 25 Leu Vai Giy Val Ile Ile Met Leu Leo Met Gly Asn Lys Giu Glu 40 Lys Glu Asn Ala Sen Lys Asn Thr Gin Giu Val Gin Ala Asn Pro 55 Ala Asn Lys Asn Gin Glu Ala Lys Glu Gly Sen Asn Ile Gin Gin 70 75 Sen Leu Sen Met Leu Val Leu Gly Pro Leu Tyr Ala Ile Asp Ala Pro Phe Ala Val Asn 90 Leu Val Ser Gin Asn Gly Arg Arg Tyr Leu Lys Ala Ser Ile Ser Leu 100 105 110 Glu Leu Ser Asn Glu Lys Leu Leu Asn Glu Val Lys Val Lys Asp Thr 115 120 125 Ala Ile Lys Asp Thr Ile Ile Glu Ile Leu Ser Ser Lys Ser Val Glu 130 135 140 Glu Val Val Thr Asn Lys Gly Lys Asn Lys Leu Lys Asp Glu Ile Lys 145 150 155 160 Ser His Leu Asn Ser Phe Leu Ile Asp Gly Phe Ile Lys Asn 165 170 INFORMATION FOR SEQ ID NO:583: SEQUENCE CHARACTERISTICS: LENGTH: 35 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...35 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:583 SMet Gly Cys Phe Ser Thr Ile Cys Cys Lys Gly Leu Thr Leu Ser Val 1 5 10 Gly Gly Phe Leu Val Met Met Arg Phe Leu Ile Phe Lys Asp Phe Cys 20 25 Lys Asp Phe INFORMATION FOR SEQ ID NO:584: SEQUENCE CHARACTERISTICS: LENGTH: 307 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...307 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:584 Met Ala Lys Lys Lys Ile Ala Ile Ser Cys Gly Asp Ile Gin Gly Val 1 5 10 Gly Leu Glu Leu Ile Leu Lys Ser His Lys Glu Val Ser Ala Leu Cys Glu Pro Leu Tyr Leu Val His Ser Giu Leu Leu Asp Thr Leu Lys Phe Cys 145 Ala Ala Asn I le Phe 225 Lys Pro Ala Ala Tyr 305 Leu Asp so Ala Pro Gin Ser Ala Asp Leu Ala 115 Leu Lys 130 Ser Lys Val Ser Phe Gin Pro His 195 Leu Lys 210 Leu Gly Ile Thr Leu Lys Pro Ile 275 Tyr Gin 290 Leu Ala Asn Leu Gly Ser 100 Trp Gin Leu Gin Lys 180 Ala Ala Pro Pro Ala 260 Leu Asn Ala Pro Ala Lys Gin Arg Phe Leu 165 Ser Giy Ile Leu Phe 245 Leu Arg Lys Tyr Leu Tyr Giu Gin Tyr Val 150 Ile Thr Giu Gin Pro 230 Tyr Tyr Aia Ala Giu 55 Leu Ser Vali Ala Lys 135 Gly Gin Gin Giu Glu 215 Ala Val Phe Ser Asn 295 40 Thr As n Phe Asp Gin 120 Asp Leu Vali Ala Gly 200 Ser Asp Ser Asp Thr 280 His Lys Ser Giu Gly 105 Ile His Phe Lys Lys 185 Leu Asn Ser Met Giu 265 Asp Lys Thr Ser Ser 90 Ile Pro Gin Ser Ala 170 Ile Phe Gin Ala Ser 250 Ser His Ser Leu Leu Thr 75 Phe Cys Phe Ile Asp 155 Leu Val1 G ly Thr Phe 235 His Ile Gly Tyr Glu Asn Ile Lys Thr Val1 Ile 140 His Val1 Gin Giu Leu 220 Ala Asp Asn Thr Leu 300 Arg Ala Gly Lys Leu Gly 125 Met Val1 Lys Val1 Giu 205 Gly Pro Val1 Val1 Ala 285 Asn Ala Ile Lys Ala Pro 110 His Met Pro Phe Cys 190 Asp Phe Asn Gly Ser 270 Phe Ala Asn Ala Val1 Cys Ile Thr Leu Leu Leu 175 Gly Giu Glu Lys Leu 255 Leu Asp Ile Gin Ile Ser Giu Asn Asp Gly Ser 160 Leu Phe Lys Cys Arg 240 Ala Asn Ile Lys
S.
55
S
S.
S
S
INFORMATION FOR SEQ ID NO:584: SEQUENCE CHARACTERISTICS: LENGTH: 307 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION' .307 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:584 Met Ala Lys Lys Lys Ile Ala Ile Ser Cys Gly Asp Ile Gin Gly Val 1 5. 10 Gly Leu Glu Leu Ile Leu Lys Ser His Lys Giu Val Ser Ala Leu Cys 25 Giu Pro Leu Tyr Leu Val His Ser Gu Leu Leu Glu Arg Ala Asn Gin 40 Leu Leu Asp Asn Ala Tyr Giu Thr Lys Thr Leu Asn Ala Ile Ala Ile 55 Asp Thr Leu Lys Phe Cys 145 Ala Ala Asn Ile Phe 225 Lys Pro Ala Ala 305 Ala Gin Ala Leu Leu 130 Ser Val1 Phe Pro Leu 210 Leu Ile Leu Pro 290 Leu Pro Ser Asp Ala 115 Lys Lys Ser Gin His 195 Lys Gly Thr Lys Ile 275 Gin Ala Leu Gly Ser 100 Trp Gin Leu Gin Lys 180 Ala Ala Pro Pro Ala 260 Leu Asn Pro Ala Lys Gin Arg Phe Leu 165 Ser G ly Ile Leu Phe 245 Leu Arg Lys Leu 70 Tyr Giu Gin Tyr Val 150 Ile Thr Glu Gin Pro 230 Tyr Tyr Ala Ala Leu Ser Val Ala Lys 135 Gly Gin Gin Glu Glu 215 Ala Val1 Phe Ser Asn 295 As n Phe Asp Gin 120 Asp Leu Val Ala Gly 200 Ser Asp Ser Asp Thr 280 His Ser Glu Gly 105 Ile His Phe Lys Lys 185 Leu Asn Ser Met Giu 265 Asp Lys Ser Ser 90 Ile Pro Gin Ser Ala 170 Ile Phe Gin Ala Ser 250 Ser His Ser Thr 7S Phe Cys Phe Ile Asp 155 Leu Val Gly Thr Phe 235 His Ile Gly Tyr Ile Lys Thr Val Ile 140 His Val Gin Glu Leu 220 Ala Asp Asn Thr Leu 300 G ly Lys Leu Gly 125 Met Val1 Lys Val Giu 205 Gly Pro Val Val1 Ala 285 Asn Lys Ala Pro 110 His Met Pro Phe Cys 190 Asp Phe Asn dly Ser 270 Phe Ala Val Cys Ile Thr Leu Leu Leu 175 Giy Giu Giu Lys Leu 255 Leu Asp Ile Ser Glu Asn Asp Gly Ser 160 Leu Phe Lys Cys Arg 240 Ala Asn Ile Lys *0.
00* INFORMATION FOR SEQ ID NO:585: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 702 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .702 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:585 Val Ala Arg Leu Val Val Lys Arg Arg Lys Ile Asp Tyr Lys Gin Ser 1 5 10 Ile Gin Sen Asp Sen Gin Tyr Leu Gin Ala Unk Leu Asn Gin Phe Giu 25 Asn Lys Giu Val Tyr Glu Asn Gin Tyr Phe Leu Val Leu Giu Sen Thr 40 His Ser Leu His Gly Val Leu Glu His Lys Lys Lys Sen Phe Met His S5 Ala Asn Arg Glu Asn Phe Lys Asp Ile Leu Sen Tyr Lys Ala His Phe
S
*5
S
S
Leu Pro Ile Ser Ile 145 Lys Leu Ser Met Lys 225 Lys Gly Leu His Phe 305 Pro Phe Val Thr Arg 385 Phe Phe Phe Glu Leu 465 Arg Asn Leu Gly
LYS
545 Val Gin Lys Asn Asp 130 Gin Ala Tyr Val Ser 210 Thr Ala Leu Lys Arg 290 Glu Leu His Asn Leu 370 Leu Phe Cys Leu Asp 450 Thr Pro Asn Leu 530 Asn Glu Glu Leu Gly 115 Ser Glu Tyr Gin Asn 195 Asn Lys Pro Leu Gly 275 Leu Arg Ser Asn Gly 355 Ile Leu Lys Leu Ser 435 Met Pro Ser Leu Val 515 Leu Asp Asn Lys Ser Leu Ala Asn 150 Glu Pro Leu Lys Ser 230 Glu Glu Phe Leu Leu 310 Lys Val Leu Leu Asp 390 Tyr Asn Asp Ile Phe 470 Gin Ala Leu Tyr Phe 550 Leu Ala Arg Lys Ala Asn Gly Val Val Val Leu Ala Leu Gin 580 585 Asp Ile Tyr 590 488 Gin Leu Ser Gly Val Lys Asn Ala His Ser Phe Leu Ser Asn Met Gly 595 600 605 Thr Leu Ile Leu Tyr Pro Gin Lys Asn Ala Arg Glu Leu Lys His Asn 610 615 620 Phe Asn Val Pro Leu Ser Glu Thr Glu Ile Ser Phe Leu Glu Asn Thr 625 630 635 640 Pro Leu Tyr Ala Arg Gin Val Leu Val Lys Asn Leu Gly Asn Gly Ser 645 650 655 Ser Asn Met Ile Asp Val Ser Leu Giu Gly Leu Gly Cys Tyr Leu Lys 660 665 670 Ile Phe Asn Ser Asp Ser Ser His Val Asn Lys Val Lys Ala Leu Gln 675 680 685 Lys Asp Tyr Pro Thr Glu Trp Arg Glu Lys Leu Leu Lys Ser 690 695 700 INFORMATION FOR SEQ ID NO:586: SEQUENCE CHARACTERISTICS: LENGTH: 293 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori 9*99 (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...293 9. 9.
**9 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:586 Met Gin Glu Asp Trp Gin Ala Val Gin Asp Thr Ile Lys Val Val Ser 1 5 10 *000 Asp Val Lys Ala Gly Asn Phe Ala Val Arg Ile Thr Ala Glu Pro Ala 25 Ser Pro Asp Leu Lys Glu Leu Arg Asp Ala Leu Asn Gly Ile Met Unk 40 Tyr Leu Gin Glu Ser Val Gly Thr His Met Pro Ser Ile Phe Lys Ile .50 55 Phe Glu Ser Tyr Ser Gly Leu Asp Phe Arg Gly Arg Ile Gln Asn Ala 70 75 Ser Gly Arg Val Glu Leu Val Thr Asn Ala Leu Gly Gin Glu Ile Gin 85 90 Lys Met Leu Glu Thr Ser Ser Asn Phe Ala Lys Asp Leu Ala Asn Asp 100 105 110 Ser Ala Asn Leu Lys Glu Cys Val Gin Asn Leu Glu Lys Ala Ser Asn 115 120 125 Ser Gin His Lys Ser Leu Met Glu Thr Ser Lys Thr Ile Glu Asn Ile 130 135 140 Thr Thr Ser Ile Gin Gly Val Ser Ser Gin Ser Glu Ala Met Ile Glu 145 150 155 160 Gin Gly Lys Asp Ile Lys Ser Ile Val Glu Ile Ile Arg Asp Ile Ala 165 170 175 Asp Gin Thr Asn Leu Leu Ala Leu Asn Ala Ala Ile Glu Ala Ala Arg 180 185 190 Ala Gly Glu His Gly Arg Gly Phe Ala Val Val Ala Asp Glu Val Arg 195 200 205 Lys Leu Ala Glu Arg Thr Gin Lys Ser Leu Ser Glu Ile Giu Ala Asn 210 215 220 Ile Asn Ile Leu Val Gin Ser Ile Ser Asp Thr Ser Glu Ser Ile Lys 489 225 230 235 240 Asn Gin Val Lys Glu Val Glu Glu Ile Asn Ala Ser Ile Glu Ala Leu 245 250 255 Arg Ser Val Thr Glu Gly Asn Leu Lys Ile Ala Ser Asp Ser Leu Glu 260 265 270 Ile Ser Gin Glu Ile Asp Lys Val Ser Asn Asp Ile Leu Glu Asp Val 275 280 285 Asn Lys Lys Gin Phe 290 INFORMATION FOR SEQ ID NO:587: SEQUENCE CHARACTERISTICS: LENGTH: 52 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...52 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:587 Met Pro Lys Ser Phe Thr Leu Pro Thr Phe Val Trp Cys Leu Phe Val 1 5 10 Gly Val Ile Leu Arg Asn Ala Leu Ser Phe Phe Lys Ile His Ser Val S. 20 25 Phe Asp Arg Glu Val Ser Val Ile Gly Asn Val Ser Leu Ser Leu Phe 40 Leu Ala Tyr Ala INFORMATION FOR SEQ ID NO:588: SEQUENCE CHARACTERISTICS: LENGTH: 182 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...182 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:588 Val Gly Leu Leu Asn Ser Lys Ala Phe Lys Pro Tyr Arg Lys Ile Leu 1 5 10 Gin Met Val Phe Gin Asp Pro Tyr Ala Ser Leu Asn Pro Arg Leu Ser 25
I
490 Ile Gin Ser Ile Leu Ile Giu Ala Leu Arg Phe Ala Tyr Pro Lys Ala 40 Ser Gin Gin Giu Trp His His Leu Ala Glu Leu Cys Leu Giu Giu Val 55 Cys Leu Asn Pro Glu Leu Leu Asn Phe Tyr Ala Tyr Giu Leu Ser Gly 70 75 Gly Glu Arg Gin Arg Val Ala Ile Ala Arg Ala Ile Ala Leu Lys Pro 90 Arg Ile Ile Leu Leu Asp Giu Pro Thr Ser Ala Leu Asp Lys Ser Ile 100 105 110 Gin Lys Ser Val Leu Giu Leu Leu Leu Asn Leu Gin Giu Lys Gin Asp 115 120. 125 Leu Ser Tyr Leu Phe Ile Ser His Asp Leu Asp Val Ile Lys Ala Phe 130 135 140 Cys Asp Arg Vai Leu Val Val Ser Giu Gly Lys Ile Val Giu Thr Gly 145 iso 155 160 Ala Ile Glu Giu Vai Phe Asp Asn Pro Lys His Ala Tyr Thr Lys Arg 165 170 175 Leu Leu Giu Ser Arg Leu 180 INFORMATION FOR SEQ ID NO:589: SEQUENCE CHARACTERISTICS: LENGTH: 251 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature *o 9~ LOCATION .251 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:589 *1 5 10 Ile Pro Leu Thr Ser Ile Ser Gly Lys Ala Arg Val Lys Ile Arg His 25 Ala Phe Ser Asp Tyr Giy Ile Ser Thr Ala Thn Arg Lys Ile Pro Phe Ser Leu Lys His Tyr Val Glu Trp, Gin Ile Gly Tyr Asp Val Pro Ile 55 Lys Asp Lys Glu Lys Phe Giu Leu Thr Thr Leu Lys Asp Giu Lys Tyr 70 75 His Phe Leu Gly Ala Asn Asn Lys Val Lys Thr Leu Tyr Glu Leu Ser 90 Glu Met Ile Tyr Tyr Ala Lys Arg Leu Giy Leu Ile Sen Leu Glu Asn 100 105 110 Leu Glu Asn Thr Leu Lys Phe Leu Glu Lys Gin Lys Gin Phe Ile Glu 115 120 125 Asp Asn Phe Met Ile Thr Arg Giu Ang Phe Arg Sen His Gin Phe Gly 130 135 140 Gly Met Asp Phe Glu Leu Ser Arg Ile Sen Tyr Pro Leu Leu Ile His 145 150 155 160 Sen Phe Asp Asp Asn Giu Leu Sen Giu Ile Val Ile Lys Glu Gin Gin 165 170 175 Tyr Gly Sen Lys Thr Gin Ala Met Leu Tyr Phe Cys Phe Ser Ile Leu 180 185 190 Glu Leu Lys Thr Ala Thr Pro Leu Leu Asn Arg Thr Ala Met Pro Lys 195 200 205 Glu His Ala Leu Leu Ile Ile His Glu Thr Asn Ala Leu Val Phe Leu 210 215 220 Glu Met Leu Lys Ile Phe Gly Leu Leu Ser Gin Val His His Asn Asp 225 230 235 240 Val Leu Lys Ile Leu Glu Lys Ile Leu Gin Asn 245 250 INFORMATION FOR SEQ ID NO:590: SEQUENCE CHARACTERISTICS: LENGTH: 40 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...40 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:590 Val Ile Thr Ala Cys Phe Asn Arg Glu Lys Thr Ile Glu Asp Thr Ile 1 5 10 S, Leu Ser Val Leu Asn Gin Thr Tyr Lys Asn Ile Glu Tyr Ile Ile Ile S* 20 25 Asp Gly Ala Ser Ala Ile Ala Leu 35 9* INFORMATION FOR SEQ ID NO:591: SEQUENCE CHARACTERISTICS: LENGTH: 122 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...122 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:591 Val Phe Val Gly Leu Tyr His Gly Ala Ser Ile Phe Asp Leu Lys Phe 1 5 10 Glu Val Tyr Leu Thr Met Leu Ile Ser Leu Met Pro Phe Val Ala Thr 25 Ile Tyr Ile Asn Phe Pro Lys Thr Thr Glu Thr Ser His Gly Tyr Ala 40 492 Arg Trp Ala Asn Val Lys Asp Ile Glu Cys Phe Lys Ile Phe Ser Lys 55 Glu Gly Phe Cys Lys Val Val His Arg Leu Gly Val Gin Phe Asp Asn 70 75 Gly Phe lie Leu Gly Lys Phe Gly Phe Pro Lys Leu Arg Asn Val Cys 90 Tyr Asp Lys Pro Leu Gly Thr Met Ile Val Ala Pro Pro Gly Ala Glu 100 105 110 Lys Leu His Val Trp Leu Cys Gin Ile Tyr 115 120 INFORMATION FOR SEQ ID NO:592: SEQUENCE CHARACTERISTICS: LENGTH: 113 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...113 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:592 Met Lys Arg Leu Ala Val Ala Leu Ile Leu Val Leu Gly Val Val Trp 1 5 10 Gly Lys Ser Leu Pro Lys Trp Ala Lys Asp Cys Ser Lys Glu Met Arg 25 Ile Glu Lys Thr Gin Thr Lys Asp Glu Lys Ile Leu Val Cys Gly Met 40 Ser Asp Ile Leu Leu Ser Asp Met Asp Tyr Ser Leu Ser Ser Ala Arg 50 55 SGin Asn Ala Leu Glu Lys Val Met Glu Ala Phe Lys Gly Asp Arg Ile 65 70 75 Glu Ile Lys Ala Gly Glu Leu Lys Ala Thr Phe Ile Asp Thr Asp Lys 90 Val Tyr Val Leu Leu Arg Ile Thr Lys Lys His Val Ala Leu Met Asn 100 105 110 Glu INFORMATION FOR SEQ ID NO:593: SEQUENCE CHARACTERISTICS: LENGTH: 437 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...437 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:593 Met Asn Pro Gin Ile Gin Pro Ala Thr Lys Lys Pro Leu Lys Ser Leu 1 5 10 Leu Ala Ala Ser Ser Gly Asn Leu Val Glu Trp Tyr Asp Phe Tyr Ala 25 Tyr Ala Phe Leu Ala Pro Tyr Phe Ala Lys Glu Phe Thr His Thr Asn 40 Asp Pro Thr Leu Ala Leu Ile Ser Ala Phe Leu Val Phe Met Leu Gly 55 Phe Phe Met Arg Pro Leu Gly Ser Leu Phe Phe Gly Lys Leu Gly Asp 70 75 Lys Lys Gly Arg Lys Thr Ser Met Val Tyr Ser Ile Ile Leu Met Ala 90 Leu Gly Ser Phe Met Leu Ala Leu Leu Pro Thr Lys Glu Ile Val Gly 100 105 110 Glu Trp Ala Phe Leu Phe Leu Leu Leu Ala Arg Leu Leu Gin Gly Phe 115 120 125 Ser Val Gly Gly Glu Tyr Gly Val Val Ala Thr Tyr Leu Ser Glu Leu 130 135 140 Gly Lys Asn Gly Lys Lys Gly Phe Tyr Gly Ser Phe Gin Tyr Val Thr 145 150 155 160 Leu Val Gly Gly Gin Leu Leu Ala Ile Phe Ser Leu Phe Ile Val Glu 165 170 175 Asn Val Tyr Thr His Glu Gin Ile Ser Ala Phe Ala Trp Arg Tyr Leu 180 185 190 Phe Ala Leu Glu Gly Ile Leu Ala Leu Leu Ser Leu Phe Leu Arg Asn 195 200 205 Ile Met Glu Glu Thr Met Asp Asn Glu Ala Thr Pro Gin Lys Lys Thr 210 215 220 Asn Val Asn Asn Thr Lys Glu Thr His Ile Lys Glu Thr Gin Arg Gly 225 230 235 240 Ser Leu Lys Glu Leu Leu Asn His Lys Lys Ala Leu Met Ile Val Phe 245 250 255 Gly Leu Thr Met Gly Gly Ser Leu Cys Phe Tyr Thr Phe Thr Val Tyr 260 265 270 Leu Lys Ile Phe Leu Thr Asn Ser Ser Ser Phe'Ser Pro Lys Glu Ser 275 280 285 Ser Phe Ile Met Leu Leu Ala Leu Ser Tyr Phe Ile Phe Leu Gin Pro 290 295 300 Leu Cys Gly Met Leu Ala Asp Lys Ile Lys Arg Thr Gin Met Leu Met 305 310 315 320 Val Phe Ala Ile Thr Gly Leu Ile Val Thr Pro Ile Val Phe Tyr Gly 325 330 335 Ile Lys His Ala Thr Ser Val Tyr Glu Ala Leu Phe Tyr Glu Ile Leu 340 345 350 Ala Leu Ser Ser Met Ser Phe Tyr Thr Cys Ile Ala Gly Val Ile Lys 355 360 365 Ala Glu Leu Phe Pro Glu His Val Arg Ala Leu Gly Val Gly Leu Ala 370 175 380 Tyr Ala Ile Ala Asn Ala Leu Phe Gly Gly Ser Ala Ser Tyr Ile Ala 385 390 395 400 Leu Glu Phe Lys Gln His Gly Phe Glu Glu Gly Phe Val Gly Tyr Val 405 410 415 Met Leu Ser Ile Val Ile Phe Met Val Met Val Ile Ile Phe Pro Lys 420 425 430 Lys Thr Tyr Leu Glu 435 INFORMATION FOR SEQ ID NO:594: SEQUENCE CHARACTERISTICS: LENGTH: 146 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .146 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:594 Met Ser Ser Gly Leu Ile Tyr Ile Sen Leu Giu Val Leu Val Unk Cys 1 5 10 Leu Ile Thn Ala Leu Ile Met Tyn Tyr Val Met Lys Lys Ile Tyr Tyr 25 Ala Arg Gly Gin Ala Ile Leu Lys Gly Ala Ser Ala Lys Ala Lys Leu 40 Met Glu Phe Gin Ala Lys Sen Phe Vai Giu Ala Glu Giu Met Arg Met 55 Lys Ser Gin Glu Cys Lys Leu Gin Gin Gin Tyn Giu Asn Lys Asn Leu 70 75 Gin Leu Gin Thn His Phe Asp Lys Lys Giu Ala His Leu Lys His Leu 90 Glu Ala Gin His Lys Giu Phe Val Arg Asp Glu Lys Ang Tyr Leu Giu 100 105 110 Lys Giu Lys Lys Giu Leu Giu Lys Glu Arg Gin Ile Leu Giu Unk Giu 115 120 125 Arg Giu Asn Phe Unk Unk Gin Ang Ala Phe Val Unk Unk Unk Unk Ala 130 135 140 Lys Ala 145 INFORMATION FOR SEQ ID NO:594: SEQUENCE CHARACTERISTICS: LENGTH: 146 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc_feature LOCATION .146 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:594 Met Ser Sen Gly LeuIle Tyr Ile Sen Leu Glu Val Leu Val Unk Cys 1 5 10 Leu Ile Thr Ala Leu Ile Met Tyr Tyr Val Met Lys Lys Ile Tyr Tyr 25 Ala Arg Gly Gin Ala Ile Leu Lys Gly Ala Sen Ala Lys Ala Lys Leu 40 Met Glu Phe Gin Ala Lys Ser Phe Val Glu Ala Glu Glu Met Arg Met 55 Lys Ser Gin Glu Cys Lys Leu Gin Gin Gin Tyr Glu Asn Lys Asn Leu 70 75 Gin Leu Gin Thr His Phe Asp Lys Lys Glu Ala His Leu Lys His Leu 90 Glu Ala Gin His Lys Glu Phe Val Arg Asp Glu Lys Arg Tyr Leu Glu 100 105 110 Lys Glu Lys Lys Glu Leu Glu Lys Glu Arg Gin Ile Leu Glu Unk Glu 115 120 125 Arg Glu Asn Phe Unk Unk Gin Arg Ala Phe Val Unk Unk Unk Unk Ala 130 135 140 Lys Ala 145 INFORMATION FOR SEQ ID NO:595: SEQUENCE CHARACTERISTICS: LENGTH: 127 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...127 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:595 Met Asn Ile Lys Ile Leu Lys Ile Leu Val Gly Gly Leu Phe Phe Leu 1 5 10 Ser Leu Asn Ala His Leu Trp Gly Lys Gin Asp Asn Ser Phe Leu Gly 20 25 Ile Gly Glu Arg Ala Tyr Lys Ser Gly Asn Tyr Ser Lys Ala Ala Ser 35 40 STyr Phe Lys Lys Ala Cys Asn Asp Gly Val Ser Glu Gly Cys Thr Gin 55 Leu Gly Ile Ile Tyr Glu Asn Gly Gin Gly Thr Arg Ile Asp Tyr Lys S 65 70 75 Lys Ala Leu Glu Tyr Tyr Lys Thr Ala Cys Gin Ala Asp Asp Arg Glu 85 90 Gly Cys Phe Gly Leu Gly Gly Leu Tyr Asp Glu Gly Leu Gly Thr Ala 100 105 110 Gln Asn Tyr Gin Glu Ala Unk Asp Ala Tyr Ala Arg His Ala Phe 115 120 125 INFORMATION FOR SEQ ID NO:595: SEQUENCE CHARACTERISTICS: LENGTH: 127 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES
I
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .127 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:595 Met Asn Ile Lys Ile Leu Lys Ile Leu 1 Ser Ile Tyr Leu Lys Gly Gin Leu Tyr Cys G iu 70 Giy Ala Val Giy Gly Gin Asp Asn Asn Tyr Ser Vai Ser Glu Giy Thr Arg Cys Gin Ala Asp Giu Gly Tyr Ala Arg Leu Ser Lys Gly Ile Asp Leu His 125 Phe Phe Ala Cys Asp Asp G iy 110 Ala INFORMATION FOR SEQ ID NO:596: en.
C
C*
a
C
C. a a a.
a. Ca. C Ci) SEQUENCE CHARACTERISTICS: LENGTH: 95 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. (xi) SEQUENCE DESCRIPTION: SEQ ID NO:596 Asp Ile Ser Ile Phe Arg Glu Tyr Asp Ile Thr Leu Asp Giu Asn Thr Ala Phe Ser Ile 20 25 Ile Met Arg Giu Tyr Asp Lys Sen Val Phe 35 40 Val His Gly Arg Phe Leu Phe Giu Val Leu 50 55 Sen Gly Leu Lys Val Tyr Asp Leu Gly Leu Tyr Phe Ala Ala Phe Asn Giu Ile Asp Asn Met Thn Lys Arg Ser Ala Arg Gly Ile Gly Val Glu V/al Gly His Ser Ala Gly Ile Pro Thr Ile Gin Trp INFORMATION FOR SEQ ID NO:597: Mi SEQUENCE CHARACTERISTICS: LENGTH: 102 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...102 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:597 Val Cys Asp Ile Phe Ser Asp Gly Val Leu Leu Asp Lys Ala Leu Val 1 5 10 Ile Tyr Phe Lys Ala Pro Tyr Ser Phe Thr Gly Glu Asp Val Cys Glu 25 Ile Gln Cys His Gly Ser Pro Leu Leu Ala Gln Asn Ile Leu Gin Ala 40 Cys Leu Asn Leu Gly Ala Arg Leu Ala Lys Ala Gly Glu Phe Ser Lys 55 Lys Ala Phe Leu Asn His Lys Met Asp Leu Ser Glu Ile Glu Ala Ser 70 75 Val Gin Leu Ile Leu Cys Glu Asp Glu Ser Val Leu Asn Ala Leu Ala 90 Arg Gin Leu Gin Gly Gly 100 INFORMATION FOR SEQ ID NO:598: SEQUENCE CHARACTERISTICS: 1 LENGTH: 127 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...127 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:598 Met Phe Lys Lys Met Cys Leu Ser Leu Leu Met Ile Ser Gly Val Cys 1 5 10 Val Gly Ala Lys Asp Leu Asp Phe Lys Leu Asp Tyr Arg Ala Thr Gly 20 25 Gly Lys Phe Met Gly Lys Met Thr Asp Ser Ser Leu Leu Ser Ile Thr 40 Ser Met Asn Asp Glu Pro Val Val Ile Lys Asn Leu Ile Val Asn Arg 55 Gly Asn Ser Val Glu Ala Thr Lys Lys Val Glu Pro Lys Phe Gly Asp 70 75 Lys Phe Lys Lys Glu Lys Leu Phe Asp His Glu Leu Lys Tyr Ser Gin 90 498 Gin Ile Phe Tyr Arg Leu Asp Cys Lys Pro Asn Gin Leu Leu Giu Val 100 105 110 Lys Ile Ile Thr Asp Lys Gly Glu Tyr Tyr His Lys Phe Ser Lys 115 120 12S INFORMATION FOR SEQ ID N0:599: SEQUENCE CHARACTERISTICS: LENGTH: 502 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyiori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .502 (xi) SEQUENCE DESCRIPTION: SEQ ID N0:599 Met Thr Leu Lys Pro Tyr Pro Thr Lys Giu Thr Giy Leu Ala Ser Gin 1 S 10 Leu Ser Gly His Trp Phe Phe Gin Leu Ser Leu Phe Asn Lys Thr Asn 25 Phe Asn Pro Asn Lys Ile Trp Ile Pro Leu Giu Phe Asn Lys Arg Ser 40 Lys Ile Lys Phe Asp Lys Asp Leu Giu Ile Tyr Phe Asp Her His Giu 55 .160 Ser Phe Asn Ile Ser Lys Lys Tyr Leu Gin Giu Ile Asp Gin Giu Ser 70 75 Leu Lys Lys Ile Lys Gin Her Lys Asp Phe Phe Ser Ile Gin Lys Ile .85 90 Giu Her Lys His Asp Asn Asn Asp Ile Leu Gin. Leu Giu Phe Phe Giu :100 105 110 V090. Asn Asp Thr Ser Phe Leu Phe Ala Lys Giy Ser Phe Ala Giu Ile Leu *115 120 125 SGlu Tyr Asn Met Gin Leu Lys Ile Asp Ser Leu Ile Thr Lys Giu Phe 130 135 140 Asn Lys Leu Leu Ala Ile Val Gin Asp Her Pro Gin Asp Ser Tyr Gin 145 150 155 160 Leu Lys Ile Arg Vai Arg His Asn Asn Lys Leu Pro Arg Giu Lys Tyr *165 170 175 Thr Glu His Glu Ile Lys Leu Giu Val Tyr Asp Cys Arg Lys Ser His 180 185 190 Asp His Asn Giu Pro Ile Ile Leu Her Gin Gin Ser Thr Gly Phe Gin *195 200 205 Trp, Ala Phe Asn Phe Met Phe Giy Phe Leu Tyr Asn Val Giy Her His 210 215 220 Phe Ser Phe Asn His Asn Ile Ile Tyr Vai Met Asp Giu Pro Ala Thr *225 230 235 240 His Leu Her Val Pro Ala Arg Lys Giu Phe Arg Lys Phe Leu Lys Giu 245 250 255 Tyr Ala His Lys Asn His Val Thr Phe Vai Leu Ala Thr His Asp Pro 260 265 270 Phe Leu Val Asp Thr Asp His Leu Asp Giu Ile Arg Ile Val Glu Lys 275 280 285 Giu Thr Giu Gly Ser Val Ile Lys Asn His Phe Asn Tyr Pro Leu Asn 290 295 300 Asn Ala Her Lys Asp Her Asp Ala Leu Asp Lys Ile Lys Arg Ser Leu 305 310 315 320 Gly Val Gly Gin His Val Phe His Asn Pro Gin Lys His Arg Ile Ile 325 330 335 Phe Val Glu Gly Ile Thr Asp Tyr Cys Tyr Leu Ser Ala Phe Lys Leu 340 345 350 Tyr Leu Arg Tyr Lys Glu Tyr Lys Asp Asn Pro Ile Pro Phe Thr Phe 355 360 365 Leu Pro Ile Ser Gly Leu Lys Asn Asp Ser Asn Asp Met Lys Glu Thr 370 375 380 Ile Glu Lys Leu Cys Glu Leu Asp Asn His Pro Ile Val Leu Thr Asp 385 390 395 400 Asp Asp Arg Lys Cys Val Phe Asn Gin Gin Ala Thr Ser Glu Arg Phe 405 410 415 Lys Arg Ala Asn Glu Glu Met His Asp Pro Ile Thr Ile Leu Gin Leu 420 425 430 Ser Asp Cys Asp Arg His Phe Lys Gin Ile Glu Asp Cys Phe Ser Ala 435 440 445 Asn Asp Arg Asn Lys Tyr Ala Lys Asn Lys Gin Met Glu Leu Ser Met 450 455 460 Ala Phe Lys Thr Arg Leu Leu Tyr Gly Gly Glu Asp Ala Ile Glu Lys 465 470 475 480 Gin Thr Lys Arg Asn Phe Leu Lys Leu Phe Lys Trp Ile Ala Trp Ala 485 490 495 Thr Asn Leu Ile Lys Asn 500 INFORMATION FOR SEQ ID NO:600: SEQUENCE CHARACTERISTICS: LENGTH: 42 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori' (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...42 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:600 Val Tyr Phe Phe Leu Ala Leu Ser Gly Glu Lys Val Leu Leu Pro Val S1 5 10 Ile Gly Gly Leu Glu Lys Asn Ala Leu Glu Ala Gly Leu Leu Lys Gly 25 Asp Arg Ile Leu Leu Ser Thr Ile Lys Lys 35 INFORMATION FOR SEQ ID NO:601: SEQUENCE CHARACTERISTICS: LENGTH: 341 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES
I
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .341 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:601 Met Glu Asn Phe Lys Leu Ile Asn Phe Phe Thr Giy Gin Asn Asp Ala Gly Asp Ile Phe Phe Ser Lys Pro Sen Phe Giu Tyr Thr Thr Giu Tyr His Sen Asn Leu Ile Asn Asn 145 Lys Leu Ile Ile Glu 225 Lys Leu Giu Ile Thr 305 Giu Met Pro 130 Leu Glu Lys Giu Arg 210 Giu Phe Phe Phe Phe 290 Ile Leu Leu 115 Ser Gly Asn Ala Ile 195 Lys Ser Phe Ile Leu 275 Ala Ser Glu Giu Asn Leu Leu4 Ala Asn Gin Phe Ang Lys Gin Gly Asn 70 Ala Thr Ile Lys Asp Ile 100 Asn Thr Thr Leu Sen Pro Leu Ile His 150 Ala Met Phe 165 Leu Giu Asn 180 Leu Gin Cys Ser Val Tyr Pro Lys Ang 230 Ile Met Val 245 Asp Glu Ile 260 Lys Ala Leu Thr Thr His Asp Asn Giu 310 Lys Giu Sen 325 Lys Ala 340 Glu Val Ile 55 Thr Pro Asn Ile Met 135 Sen Ile Leu Phe Ile 215 Leu Ser Giu Phe Asn 295 Thr Ala Ser Lys Ala Leu Leu Thr 120 Thr Asn Pro Gin Asn 200 Gin Leu Ile Sen Lys 280
LYS
Gly Leu 25 Leu Leu Asn Thn Asn 105 Lys Met Leu Ile Leu 185 Pro Ile Asn Leu Gly 265 Leu Glu Val Tyr Pro Asp Pro Ile 90 Ser Pro Thn Asp Glu 170 Ala Asn Lys Leu Ile 250 Leu Ala Phe Phe Phe 330 rhr Pro Ala Ile 75 Gin Asp Gin Tyr Lys 155 Leu Ser I le Asp Phke 235 Asp His Gin Leu Lys Asn Glu Asp Ser Tyr Asp Leu Giu 140 Ile Ser Lys Leu G iu 220 Gly As n His Lys Leu 300 Asp rhr H{is ksn Ile Pro Ala Gin 125 Phe Ala Ile Glu Asn 205 Asn Trp Ang Thr Leu 285 Asn Ile Giy Ala Leu Arg Thr His 110 Phe Giu Gin Val1 Lys 190 Ala Thr Gly Val1 Lys 270 Gin Ala Ala Leu Val Lys Thr Gin Met Sen Arg Thr Asn 175 Glu Asn Pro Phe Lys 255 Met Ile Ile Leu :ys Asn rhr Glu Thn Thr Tyr Gin Tyn 160 Sen Leu Thr Leu Ile 240 Tyr Gin Gin Asn Phe 315 320 Ala Ser Asr Ile Arg His Sen Tyn Sen 335 INFORMATION FOR SEQ ID NO:602: SEQUENCE CHARACTERISTICS: LENGTH: 465 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION .465 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:602 Met Asp Phe Lys Lys Cys Pro Asn Phe Giu Lys Lys Cys Ala I Ile Leu C
C
Asp Gin Lys Asp Tyr 4 Asp 145 Glu Gin Ala Asp Glu 225 Lys Asn Val Tyr His 305 Asn Leu Tyr Lys Gly 385 Asn Leu Lys Ile Iyr Val Glu 130 Leu Ile Gly Leu Ile 210 Ile Leu Asp His Ser 290 Arg Asn Gly Ser Ile 370 Asn Asn Sex Ser Asn I Gin Lys I Asp Lys Ala Asn I Asn Lys Leu Ser I 100 Asn Phe 115 Ala Asn Ile Asp Glu Ile Leu Glu 180 Glu Asn 195 Tyr Gln Ile Pro Pro Phe Asn Glu 260 Ile Leu 275 Trp Ile Leu Ile Ala Asn Trp Thr 340 Leu Arg 355 Glu Leu Lys Arg Phe Glu Ala Ala 420 .eu ys ,ly ,ys kla ?he Phe Lys Arg Leu 165 Ile Gly Glu Ser Glu 245 Glu Ile Asp Asn Lys 325 Lys Ser Gin Glu Lys 405 Ile Va1 Lys Asp Ile 70 Ser Glu Ala Glu Asn 150 Thr Gin Asn Val Ile 230 Ser Val Leu Lys Glu 310 Ile Glt Ala Lyz 114 39( Al 11~ Leu I Pro I 4 Val 1 55 Gin Met Lys Asn Gly 135 Ile His Leu Glu Glu 215 Ser Ile Lys Glu Asp 295 Asn Lys Glu Leu Tyr 375 Lys x Tyr e Gin jeu ,ys L0 la lu Iie krg :ly 120 Phe Asp Thr Thr Ile 200 Arg Sen Asn Lys Gin 280 Asp Lys Gin Gin Let 360 Tyl Prc Lyi Al
I
Ile C 25 Asn I Thr I Pro I Ser 2 Val 105 Glu Glu Arg Asn His 185 Val Thr Ala Asn Leu 265 Gin Asn Leu Phe Ser 345 Ser Glu Phe Glu i Lys 425 .0 ;lu 'ro ~sn eu krg 90 ryr lie Arg Asn Sen 170 His Lys Lys Glu Glu 250 Glu Leu Ala Lys Phe 330 Ala Leu Ser Lys Ar5 41( Ile His Gin Pro 2 Asn Pro Pro Tyr 75 Asp Pro Lys Asp Lys Glu Arg Ile 140 Arg Glu 155 Leu Lys Asn Giu Glu Tyr Asp Gly 220 Tyr -Phe 235 Asn Thr Phe Glu Leu Ser Asn Phe 300 Glu Asn 315 Phe Asn Ile Gin Glu Glu Val Tyr 380 Giu Ile 395 Tyr Asp 3er %sn Jal Val Ile Asn Ser 125 Thr Phe Glu Thr Asp 205 Gly Lys Lys Leu Ala 285 Ala His Asn Glu Ile 365 Val LeL Lys Lys Leu Glu Val Glu Ser 110 Ser Lys Phe Leu His 190 His Leu Leu Leu Ala 270 Thr Trp Leu Gly Asn 350 Ala Asn Arg Leu Phe ly Phe Glu Lys Trp Lys Arg Arg Ile Lys 175 Lys Leu Val Tyr Asn 255 Lys Asr Lys Sei Se2 33! Are G1 Gi1 Asl Va.
Leu Leu Ser Ser Thr Ala Glu Val Tyr Lys 160 Glu Lys Lys Arg Asn 240 Thr Glu Tyr Met Ala 320 Ile 1 Asp i Ala Asp p Thr 400 1 Ser 00. Giu Gly Gly Asn 415 Glu Arg Gin 430 Asn Asn Ile 465 Ser Ser Ala Asn Asn Asn Asn Pro Ile Lys Asn Thr Ile Glu Thr 435 440 445 Thr Ser Asn Asn Ile Ile Gin Asn Asn Asp Asn Ile Ile Ile Gin 450 455 460 INFORMATION FOR SEQ ID NO:603: SEQUENCE CHARACTERISTICS: LENGTH: 193 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...193 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:603 Met Ala Leu Glu Val Val Leu Trp Asp Phe Asp 1 5 10 Gly Val Ile Phe Asp a o a ft 0 0f ft fo *f't f"_f ft *ftftf *ftt f ftf ft f ft ftt Ser Gly Gin Glu 65 Leu Leu Ile Cys Pro 145 Tyr Met Asn Ser 50 Ile Glu Asn Phe Glu 130 Pro Asp His Asp Gly Leu Phe Ser His 115 Phe Asp Pro Leu Ser Gly Lys Gly Glu 100 lle Leu Lys Ser Lys Ile Thr Ala 85 Val Ala Gly Pro Arg Glu Ser Pro 70 Ile Met Ser Ile Lys 150 Met Gly Arg 55 Ile Ile Ala Ala Thr 135 Ile Leu Leu 40 Asn Ala Glu Phe Ala 120 Lys Ile Met Lys Tyr Glu Gly Phe Lys Ala 25 Lys Gin Phe Glu Lys Ile Gin Glu Glu 75 Gin Lys Leu 90 Ile Asp Lys 105 Leu His Ser Tyr Phe Lys Ala Asn Ile 155 Ile Ala Ile Leu Glu Gin Ile Phe His Glu Ser 140 Ile Phe Val Tyr Asp Asp Tyr Leu 125 Val Gln Gin Tyr Phe Ala Arg Gin 110 Gin Glu Lys Lys His Tyr Leu Gly Asn Val Gly Tyr His Tyr Asn Ala His Tyr Leu Ser Ala 160 Ala Ser Met Ile Met 175 165 170 Lys Ala Leu Arg 180 Phe Leu Ile-Lys Trp Arg Phe 185 Trp Ala Ile Thr Ala Arg 190 INFORMATION FOR SEQ ID NO:604:
SEQUENCE.CHARACTERISTICS:
LENGTH: 141 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE'TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .141 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:604 Met
I
Phe Thr Giu Ile Tyr Ser Leu Ala Leu Phe Tyr Ala Ala Phe Val Leu Leu 130 Lys Ser Ile Tyr Leu Phe Pro 115 Leu Lys Lys Ile Asp Leu His Tyr Met Ala Giu Gly Tyr 100 Phe Asn 5 Phe Val Ala Leu Gin Phe Ser Met Ile Pro Asp Asp Val Asn 55 Leu Phe 70 Asn Lys Vai Ala Giu Asn Sen Asn 135 Leu Met 40 Ile Giy Thr Leu Ile 120 Ala Vali 25 Phe Ala Phe His Ser 105 Ala Ile Lys 10 Phe Val1 Trp Giy Arg 90 Ala Gin Leu Asp Ser Ser Met Gly Lys Pro Ile Ala Ala 75 Ala Arg Phe Ile Phe Phe Lys Sen 140 Ile Ile Lys Phe Ser Leu Leu Giy 125 Phe Arg Lys is Ser Leu Leu Giy Pro Giy Ile Val Val Phe Ser Met 110 Ser Asn Leu Ser Lys Leu Gly Ser Ala Asp
C
CCCI
C C *1 C
C.
CC..
C. CC
C
CC..
C CC C C C CC C
CC
CCC.
C
CCC.
INFORMATION FOR SEQ ID NO:605: SEQUENCE CHARACTERISTICS: LENGTH: 159 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION I1.. .159 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:605 Val Lys Cys Leu Leu Ile Lys Lys Ser Leu Leu Phe Ala Leu 1 5 -10 Leu Pro Asp Leu Lys Thr Thr Thr Pro Ile Leu Ala Pro Met 25 Val Ala Gly Arg Leu Unk Unk His Leu Val Gin His Tyr Leu 40 Leu Giu His Val Lys Gly Phe Met Gly Lys Gly Val Ile Leu 55 Leu Sen Gly Ala Gin Arg Ala Lys Ile Val Val Ile Gly Gly 70 75 Val Gly Met Giu Sen Ala Lys Val Leu Unk Gin Met Gly Unk 90 Tbr Ile Leu Glu Leu Asp Tyr Ala Lys Leu Gin Asn His Pro 100 105 110 Lys Pro Ser Val Leu Ala Gly Gly Gly Val Lys Val Tyr Tyr His Gin Unk 145 504 Leu Tyr Asp Leu Giu Val Leu Ser Val Asn Giu Ala Asn Ile Ile 115 120 125 Ala Leu Asn Gly Unk Vai Gly Leu Val Giy Ala Val Leu Val Thr 130 135 140 Ser Gin Thr Pro Lys Val Unk Leu Arg Arg His Leu Lys Tyr 150 155 INFORMATION FOR SEQ ID NO:606: SEQUENCE CHARACTERISTICS: LENGTH: 376 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: WA ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .376 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:606 e.g.
0* t g.e.
*0*g 0e C. 9 *4 .9 6* 9 Met
I
Ser Glu Lys
LYS
65 Asp Thn Giu Pro Glu 145
LYS
Met Leu Ser Gin 225
LYS
Met Phe Al a Gin Leu 5o Gin Leu Arg Gin Tyr 130 Arg
LYS
Gly Ala Asn 210 Leu Ala Ala Ser Asn Giu Leu Lys Giu Gly Ala 115 Ala Leu Thr Val Leu 195 Leu Glu Thn Ile Asn Glu Val Asn
LYS
Lys 85 Ile Lys Val Tyrn Ala 165 Ser Ser Asn Thr 245 Lys Leu Gin Ala Thr Giu 70 Tyr Leu Asp Leu Tyr Thr Leu Lys Arg Lys 230 Leu Ile Lys Phe Ala His 55 Leu Lys Thn Asn Asn 135 Thn Asp Gin Lys 215 Phe Ile Asn Asn Gly Ser Phe Lys Glu Asp 40 Asp Phe Leu Val Asp Tyr Lys Giu Lys Ala Lys Sen 105 Pro Leu Tyr 120 Gin Glu Thr Pro Gin Val Lys Asp Lys 170 Giu Giu Gin 185 Ala Ile Giu 200 Giu Leu Asp Asp Ser Lys Phe Asn Sen 250 Giu Lys Tyr 265 Val Lys Asp 280 Phe Aia Glu Ang Glu Lys Lys Phe Lys 155 Ala Asn Giu Asn Ala 235 Glu Leu Asp Asn Leu Asp Ala Ala Ala Lys Thr 140 Thr Gin Lys Tyr Ile 220 Lys Arg Ang Val Leu Ala Lys Ile Vai Phe Ser Sen Leu Val Ala Phe Glu Lys Leu Lys Leu Tyr Leu 125 Gin Sen Ala Lys Sen 205 Asp Asp Leu Gly Glu 285 Gly Tie Ala Val Val G iiu Gly 110 Leu Giu Ser Leu Ala 190 Asn Tyr Ile Ala Tyr 270 Leu 000 275 Leu Thr Lys Asn Phe Thr Asn Gin Lys Leu Sen Phe Ala Gin Lys Gin Cys Leu Leu Val 310 Ser Ile Leu Lys 325 Pro Met Met Ser 340 Phe Asn Phe Phe 355 Lys Asn Asn Pro 505 295 300 Leu Asp Ser Phe Asn Phe Asp Thr Gin Ser 315 320 Lys Thr Asn Giu Tyr Asn Ile Phe Val Asp 330 335 Asp Lys Thr Thr Met Gin Lys Giu His Tyr 345 350 Lys Thr Val Val Ser Ala Tyr Arg Asn Asn 360 365 Phe Glu 375 INFORMATION FOR SEQ ID NO:607: SEQUENCE CHARACTERISTICS: LENGTH: 352 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .352 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:607
S
S
55.5
S.
S
1Met Asp Phe Val Gly Pho Giu Asp Leu Lys Cys Ser Leu Gly Ile 65 His Leu Ser Tyr Tyr 145 Leu Ser Leu Leu Leu 225 Thr Gin Giu Val 50 Ala Leu Phe Ile Gin 130 Giu Pro Lys Leu Pro 210 Ser Lys Ile 35 Glu Leu Aia Ser Pro 115 Lys Asn Giu Trp 195 Ala Cys Val 20 Pro Val Giu Thr Asn 100 Tyr Arg Asn Ala Arg 180 Ile Ser Glu
S
Phe Ala Phe Thr Phe Ile Val Leu Gin 165 Sen Gly His Ile V1al Lou Lou Pro 70 His Lys Lou Arg Asp 150 Leu Ile Val Phe Ile 230 Ile Ile Gly 55 Phe Lys Asn Ala Gin 135 Lou Lys Ile His Ile 215 Lou Arg Ala Val Ile Asn Ala Pro 120 Asn Ile Lys Ala Met 200 Giu Ile Asn Asp Lys 25 Lou Lys His Val Val Pro' Asp Giu Val 75 Arg Sen Ile 90 Lys Lou Ala 105 Lys Thr Lys Arg Sen Leu His Ala Phe 155 Ile Ala Trp 170 Sen Lys Lou 185 His Ser Gly Lou Ile Ala Cys Gly Pro 235 Lys Leu Ala Sen Ile Asp.
Phe Ile Cys 140 Cys Lys Asn Gly Ile 220 Giy ksp ly Phe Tyr Ile Ala Sor Tyr 125 Lou Lys Leu Ala Ser 205 Leu G1.
Lys Asp Lou Thr G iu Leu Lou 110 Ser Lys Asp Lys *Asn 190 *Ser His Arg Giu Phe Giu Thr Asp Ile Arg Trp Thr Tyr Asp 175 Val Pro Glu Lys Asn Ile Lys Pro Asn Phe Lys Lou Glu Asp 160 Lys Asp Val Lys Ala 240 Glu Giu Lou Lou Lys Giu Val Pro 245.
Ala His Lou Tyr Asp Thr 2S55 506 Leu Cys Ala Ser Cys Asn Arg 305 Gly Ile Ser Giy 275 Ser Arg Asn dly Leu 260 Asn Ile Pro Asp Phe 340 His Vai Glu Leu Leu Gly 315 Ile Gin 330 Ser His Asn Leu 270 Ala Leu 285 Ala Ser Thr Pro Glu Ser Met Gin 350 Ser Val Phe Asp Ile Ala Pro Asn 320 Giu Lys 335 Giu Arg Lys Asn Leu 345 00.
0 000*.0 So INFORMATION FOR SEQ ID NO:608: SEQUENCE CHARACTERISTICS: LENGTH: 88 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .88 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:60-8 Val Gly Vai Leu Ser Leu Lys Ile Giu Ala Ile Ser Asn Phe Tyr 1 5 10 Leu Cys Val Leu Gly Val Leu Leu Aia Cys Phe Tyr Leu Leu Asp 25 Tyr Tyr Leu Met Gin Glu Arg Leu Phe Arg Giu Gin Tyr Gin Trp 35 40 Ile Lys Asn Axg Leu Lys Thr Aso Giu Arg Leu Phe Giu Val Phe so 55 Ile His Gin Thr Cys Gin Ser Thr Gin Phe Leu Ser Pro Cys Val 70 Leu Val Phe Ser Pro Ile Gly Arg INFORMATION FOR SEQ ID NO:609: SEQUENCE CHARACTERISTICS: LENGTH: 86 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FE-ATURE:, NAME/KEY: mise...feature LOCATION .86 Met Gly Glu Asn Asn Pro (xi) SEQUENCE DESCRIPTION: SEQ ID NO:609 Ser Leu Gly Ala Val Val Ser Ser Leu Leu Cys His Lys Leu 10 Ala Ile Leu Asp Leu Arg Ala Tyr Arg Unk Urik Ala Tyr Tyr 25 Asn Lys Asp Thr Leu Leu Ile Lys Gly Lys Lys Arg Leu Leu 40 45 Tyr Ile Lys Ala His Ile Unk Leu Asn Leu Leu Trp Thr Ile 55 60 Arg Thr Unk Ser Leu Gly Lys Phe Thr Gin Asn Pro Thr Giu 70 75 Pro Thr Asn Asn His Glu His Tyr Arg Gin INFORMATION FOR SEQ ID fi) SEQUENCE CHARACTERISTICS: LENGTH: 76 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .76 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:610 Met Lys Lys Thr Thr Leu Phe Val Leu Gly Leu Leu Phe Asn Ser Ser 1 5 10 Leu Sen Ala Val Asp Gly Ile Sen Gin Thn Glu Pro Ser Sen Leu Asn 25 Leu Ala Glu Asp Ser Leu Pro Leu Asn His Sen Asn Ala Gin Lys Leu 35 40 Ser Leu Lys Asn Ala Tnp Asn Ang Val Leu Sen Asn His Glu Gly Leu so 55 His Ala Gin Asn Thr Pro Leu Sen Glu Arg Val Lys 65 70 INFORMATION FOR SEQ ID NO:6l1: SEQUENCE CHARACTERISTICS: LENGTH: 98 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .98 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:61i Val Lys Lys Val Giu Ser Met Asn Val Val Pro Phe Ile Asp Ile Met 1 5 10 Leu Val Leu Leu Val Ile Val Leu Thr Thr Ala Ser Phe Val Gin Thr 25 Ser Lys Leu Pro Ile Ser Ile Pro Gin Val Asp Lys Asp Ser Thr Asp 40 Ser Lys Asp Val Leu Asp Lys Lys Gin Val Thr Ile Ala Ile Ser Asn 55 Lys Gly Ser Phe Tyr Phe Asp Asp Lys Glu Ile Ser Phe Giu Asn Leu 70 75 Lys His Lys Val Ser Thr Leu Ala Lys Asp Thr Pro Ile Val Phe Ala 90 Arg Arg INFORMATION FOR SEQ ID NO:6i2: SEQUENCE CHARACTERISTICS: LENGTH: 162 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE:.
NAME/KEY: misc-feature LOCATION .162 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:612 Met Gly Sen Tyr Thr Phe Pro Leu Ile Leu Lys Pro Ile Phe Ile Asn 1 S 10 Lys Val Pro Val Thr Ile Asp Phe Tyr Ala Asn Ala Asn Tyr Phe Leu 25 Ile Tyr Gly Ala Leu Ala Asn Ala Val Val Gly Sen Ile Asn Ala Leu 40 Asn Asp Giu Ile Arg Phe Lys Ang Asn Ala Gin Ile Giu Glu Ala Giu so 55 Leu Giy Thx Asp Gly Ile Lys Ile Lys Pro Ile Ala Leu Tyr Asn Pro 70758 Sen Giu Gly Tyr Leu Asn Tyn Ala Leu Sen Ser Val Phe Ile Phe Ile 90 Leu His Gin Val Met Leu Ile Ala Ser Sen Met Phe Thr Sen Sen Arg 100 105 110 Arg Leu Glu Leu Ala Leu Leu Asp Lys Lys Gin Ile Ala Leu Arg Leu 115 120 125 Cys Ala Arg Leu Leu Val Phe Met Gly Ala Phe Ser Val Phe Val Leu 130 135 140 Trp Tyr Phe Gly Ala Leu Phe Ser Phe Tyn Gly Ile Glu Ang His Gly 145 150 155 160 Ser Ala INFORMATION FOR SEQ ID NO:613: SEQUENCE CHARACTERISTICS: LENGTH: 58 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...58 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:613 Val Ile Met Thr Lys Leu Asp Gly Thr Ser Lys Gly Gly Ala Ile Leu 1 5 10 Unk Val Leu Tyr Glu Leu Lys Leu Pro Ile Leu Tyr Leu Gly Met Gly 25 Glu Lys Glu Asp Asp Leu Ile Ala Phe Asp Glu Glu Arg Phe Ile Glu 40 Asp Leu Val Asp Ala Val Phe Val Glu Gin INFORMATION FOR SEQ ID NO:614: SEQUENCE CHARACTERISTICS: LENGTH: 66 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein S: (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...66 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:614 Val Cys Gly Ala His Gly Lys Ser Ser Ile Thr Unk Met Leu Ser Ala 1 5 10 Ile Cys Pro Ala Phe Gly Unk Ile Ile Gly Arg His Ser Lys Glu Phe 25 Asp Ser Asn Val Unk Glu Ser Ala Asp Met Ser Leu Val Phe Glu Unk 40 Asp Glu Ser Asp Ser Ser Phe Phe Ile Phe Gin Pro Phe Leu Arg Asp 55 Cys Ala INFORMATION FOR SEQ ID NO:615: SEQUENCE CHARACTERISTICS: LENGTH: 116 amino acids Met 1 Pro Leu Val Thr Ile Asp Unk TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...116 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:615 Ala Ile Ala Ile Lys Asp Leu Leu Ser Ala 5 10 Leu Asp Lys Ile Ser Met Pro Ser Ser Ala 25 Gin Phe Leu Lys Asn Thr Ala Pro Leu Phe 40 L Asn Leu Gin Glu Gly Thr Phe Ser Leu Tyr 55 Gin Ser Ala Gin Ile Asn Leu Asp Ile Ala 70 75 STyr Ile Asp Thr Ile His Thr Arg Tyr Ala 90 Ala Lys Ile Ala Leu Asp Leu Gly Gin Lys 100 105 Leu Gly Pro 115 Tyr Lys Val
E
F
c a a a..
INFORMATION FOR SEQ ID NO:615: SEQUENCE CHARACTERISTICS: LENGTH: 116 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...116 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:615 Met Ala Ile Ala Ile Lys Asp Leu Leu Ser Ala 1 5 10 Pro Leu Asp Lys Ile Ser Met Pro Ser Ser Ala 25 Leu Gin Phe Leu Lys Asn Thr Ala Pro Leu Phe 40 Val Asn Leu Gin Glu Gly Thr Phe Ser Leu Tyr 55 Thr Gin Ser Ala Gin Ile Asn Leu Asp Ile Ala .70 75 Ile Tyr Ile Asp Thr Ile His Thr Arg Tyr Ala Asp Ser Asn ;1n Asn Asn Tyr Asp Ser Asn Gin Asn Leu Val Ile Glu Met Leu Lys Leu Val Ile Glu Met Lys Gin Pro Tyr Unk Ser 110 Val Lys Gin Pro Tyr Unk Val Leu Gly Leu Gin Asp Unk Val Leu Gly Leu Gin Asp Leu Thr Ser Tyr Tyr Leu Unk Leu Thr Ser Tyr Tyr Leu a. a a. a a a.
a a..
90 Asp Ala Lys Ile Ala Leu Asp Leu Gly Gin Lys Asn Leu Ser Unk Unk 100 105 110 Unk Leu Gly Pro 115 INFORMATION FOR SEQ ID NO:616: SEQUENCE CHARACTERISTICS: LENGTH: 82 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...82 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:616 Met Pro Asp Asn Leu His Leu His Thr Leu Leu Unk Lys Phe Leu Gin 1 5 10 Gin Arg Ser Phe Asn Tyr Pro Asn Pro Leu Cys Ala Phe Ile Leu Ile 25 Leu Cys Asn Leu Pro Phe Ile Leu Ile Ser Val Leu Phe Arg Leu Asp 35 40 Ala Tyr Ala Leu Ile Val Ile Ser Leu Val Phe Ile Unk Cys Tyr Leu 50 55 Ile Gly Unk Ala Tyr Leu Asn Arg Gin Val Cys Ala Leu Glu Lys Arg 65 70 75 Ala Phe INFORMATION FOR SEQ ID NO:616: SEQUENCE CHARACTERISTICS: LENGTH: 82 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE:- ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...82 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:616 Met Pro Asp Asn Leu His Leu His Thr Leu Leu Unk Lys Phe Leu Gin 1 5 10 Gin Arg Ser Phe Asn Tyr Pro Asn Pro Leu Cys Ala Phe Ile Leu Ile 25 512 Leu Cys Asn Leu Pro Phe Ile Leu Ile Ser Val Leu Phe Arg Leu Asp 40 Ala Tyr Ala Leu Ile Val Ile Ser Leu Val Phe Ile Unk Cys Tyr Leu 55 Ile Gly Unk Ala Tyr Leu Asn Arg Gin Val Cys Ala Leu Glu Lys Arg 70 75 Ala Phe INFORMATION FOR SEQ ID NO:617: SEQUENCE CHARACTERISTICS: LENGTH: 77 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...77 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:617 Val Asn Glu Leu Lys Asn Ser Lys Gin Val Leu Gly Asn Gly Lys Ala 1 5 10 SAsp Leu Ser Asn Glu Asn Thr Lys Val Arg Gin Thr Lys Thr Asn Leu 25 Thr Glu Lys Asn Gin Arg Leu Thr Thr Glu Lys Thr Glu Leu Asn Asn 35 40 Lys Ile Thr Gly Leu Ala Thr Glu Lys Glu Arg Leu Ala Ala Asp Lys 50 55 Glu Asn Leu Thr Lys Glu Ser Arg Gin Arg Lys.Pro Asn 70 INFORMATION FOR SEQ ID NO:618: SEQUENCE CHARACTERISTICS: LENGTH: 176 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...176 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:618 Met Asp Leu Gin Gin Ile Asp Glu Leu Glu Asn Lys Phe Glu Glu Gin 1 5 10 Glu Glu Gin Ala Gln Asp Thr Pro Leu Lys Gin Glu Pro Ser Thr Lys 25 Glu Val Lys Ile Pro Lys Lys Arg Gly Arg Lys Lys Ser Leu Leu Asp 40 Glu Asp Lys Lys Lys Ser Phe Asn Ile Ala Phe Ser Pro Cys Val Ile 55 Lys Glu Leu Asn Glu Phe Leu Leu Glu Phe Gly Ser Phe Lys Glu Thr 70 75 Arg Ser Thr Phe Ile Glu Glu Ala Leu Ile Arg His Leu Lys His Arg 90 Lys Asn Thr Gin Glu Gin Lys Leu Leu Lys Gin Leu Glu Arg Leu Gin 100 105 110 Asn Lys Glu Lys Gly Ile Met Lys Thr Met Asn Leu Asn Glu Phe Phe 115 120 125 Thr His Lys Ile Ile Tyr Lys Asp Thr Pro Leu Lys Phe Lys Asp Thr 130 135 140 Leu Glu Gin Glu Ile Ser Gin Ala Ser Leu Val Glu Lys Leu Ile Leu 145 150 155 160 Ala Asn Ile Leu Ala Asn Met Val Phe Ala Lys Ile Ser Asn Glu Asn 165 170 175 INFORMATION FOR SEQ ID NO:619: SEQUENCE CHARACTERISTICS: LENGTH: 144 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature S(B) LOCATION 1...144 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:619 Met Gly Cys Tyr Gly Ile Gly Ile Ser Arg Leu Leu Ser Val Ile Leu 1 5 10 Glu Gin Lys Ser Asp Asp Leu Asp Cys Val Trp Thr Lys Asn Thr Ala 20 25 Pro Phe Asp Val Val Ile Val Val Ser Asn Leu Lys Asp Glu Ala Gin 40 Lys Lys Leu Ala Phe Glu Val Tyr Glu Arg Leu Leu Gin Lys Gly Val 50 55 Asp Ala Leu Leu Asp Asp Arg Asp Ala Arg Phe Gly Ala Lys Met Arg 70 75 Asp Phe Glu Leu Ile Gly Glu Arg Leu Ala Leu Ile Val Gly Lys Gin 85 90 Thr Leu Glu Ser Lys Glu Phe Glu Cys Ile Lys Arg Ala Asn Leu Glu 100 105 110 Lys Gin Thr Ile Lys Asp Ile Gly Ile Arg Arg Lys Asn Phe Arg Asn .115 120 125 Val Ser Glu Arg Ile Arg Gly Gly Asn Gly Lys Asn Ser Asp Trp Leu 130 135 140 INFORMATION FOR SEQ ID NO:620: SEQUENCE CHARACTERISTICS: LENGTH: 90 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...90 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:620 Met Glu Ile Gin Gin Thr His Arg Lys Ile Asn Arg Pro Leu Val Ser 1 5 10 Leu Val Leu Ala Gly Ala Leu Ile Ser Ala Ile Pro Gin Glu Ser His 25 Ala Ala Phe Phe Thr Thr Val Ile Ile Pro Ala Ile Val Gly Gly Ile 40 Ala Thr Gly Thr Ala Val Gly Thr Val Ser Gly Leu Leu Ser Trp Gly 55 Leu Lys Gin Ala Glu Glu Ala Asn Lys Thr Pro Asp Lys Pro Asp Lys 70 75 Val Trp Arg Ile Gin Ala Gly Lys Gly Leu INFORMATION FOR SEQ ID NO:621: SEQUENCE CHARACTERISTICS: LENGTH: 268 amino acids TYPE: amino acid TOPOLOGY: linear *o (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...268 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:621 Met Ser Glu Lys Glu Arg Leu Asn Glu Val Ile Leu Glu Glu Glu Asn 1 5 10 Asn Gly Ser Gly Thr Lys Lys Val Phe Leu Ile Val Ala Ile Ala Ile 25 Ile Ile Leu Ala Val Leu Leu Met Val Phe Trp Lys Ser Thr Arg Val 40 Ala Pro Lys Glu Thr Phe Leu Gin Thr Asp Ser Gly Met Gin Lys Ile 55 Gly Asn Thr Lys Asp Glu Lys Lys Asp Asp Glu Phe Glu Ser Leu Asn 70 75 Met Asp Ser Pro Lys Gin Glu Asp Lys Leu Asp Lys Val Val Asp Asn 90 Ile Lys Lys Gin Glu Ser Glu Asn Ser Met Pro Ile Gin Thr Asp Gin 100 105 110 Ala Gin Met Glu Met Lys Thr Thr Glu Glu Lys Gin Glu Ser Gin Lys 115 120 125 Glu Leu Lys Ala Val Glu Pro Ile Pro Met Ser Thr Gin Lys Glu Ser 130 135 140 Gin Ala Val Ala Lys Lys Glu Thr Pro His Lys Lys Pro Lys Val Ala 145 150 155 160 Pro Lys Asp Lys Glu Ala His Lys Asp Lys Ala Lys His Ala Ala Lys 165 170 175 Glu Pro Lys Val Lys Lys Glu Ala Arg Lys Glu Val Ser Lys Lys Ala 180 185 190 Asn Ser Lys Thr Asn Leu Thr Lys Gly His Tyr Leu Gin Val Gly Val 195 200 205 Phe Ala His Thr Pro Asn Lys Ala Phe Leu Gin Glu Phe Asn Gin Phe 210 215 220 Pro His Lys Ile Glu Asp Arg Gly Ala Thr Lys Arg Tyr Leu Ile Gly 225 230 235 240 Pro Tyr Lys Ser Lys Gin Glu Ala Leu Met His Ala Asp Glu Val Ser 245 250 255 Lys Lys Met Thr Lys Pro Val Val Ile Glu Val Arg 260 265 INFORMATION FOR SEQ ID NO:622: SEQUENCE CHARACTERISTICS: LENGTH: 171 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature S(B) LOCATION 1...171 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:622 Val Glu Tyr Tyr Ala Phe Asn Phe Ser Val Leu Asp Phe Val Leu Met S1 5 10 Gly Lys Ala Thr His Leu Asn Leu Phe Ala Met Pro Lys Ala Lys His 25 Ile Lys Glu Ala Thr Ser Val Leu Glu Arg Leu Asp Leu Glu Ser Leu 35 40 Lys Asp Gin Gly Ile Asn Asp Leu Ser Gly Gly Gin Arg Gin Met Val 50 55 SLeu Leu Ala Arg Ser Leu Leu Gin Arg Thr Pro Leu Leu Leu Leu Asp 70 75 Glu Pro Thr Ser Ala Leu Asp Leu Lys Asn Gin Ala Leu Phe Phe Asp 90 Ala Ile Lys Asp Glu Met Lys Lys Arg Glu Leu Ser Val Leu Val Asn 100 105 110 Ile His Asp Pro Asn Leu Val Ala Arg His Ser Thr His Val Val Met 115 120 125 Leu Lys Asp Lys Lys Leu Phe Leu Gin Ala Ser Thr Pro Ile Ala Met 130 135 140 Thr Ser His Asn Leu Ser Ala Leu Tyr Asp Thr Pro Leu Unk Ala Ile 145 150 155 160 Trp His Asp Asp Lys Leu Val Val Tyr Ala Leu 165 170 INFORMATION FOR SEQ ID NO:623: SEQUENCE CHARACTERISTICS: LENGTH: 102 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...102 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:623 Met Met Ala His Ser Leu Ile Leu Val Ser Lys Thr Ser Leu Ser Asn 1 5 10 Leu Leu Ile Phe Val Val Gin Pro Asp Gly Lys Leu Ser Met Thr Asp 25 Ala Ala Ile Asp Pro Asn Met Thr Asn Ser Gly Leu Arg Trp Tyr Arg 40 Val Asn Glu Ile Ala Glu Lys Phe Lys Leu Ile Lys Asp Lys Ala Leu 55 Val Thr Val Ile Asn Lys Gly Tyr Gly Lys Asn Pro Leu Thr Lys Asn 70 75 Tyr Asn Ile Lys Asn Tyr Gly Glu Leu Glu Arg Val Ile Lys Lys Leu 90 Pro Leu Val Arg Asp Lys 100 INFORMATION FOR SEQ ID NO:624: SEQUENCE CHARACTERISTICS: LENGTH: 116 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...116 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:624 Leu Lys Val Thr Asn Pro His Leu Leu Val Val Ile Gin Asp Leu Asn 1 5 10 Ala Arg Ile Ala Leu Met Lys Leu Leu Phe Gin Asn Val Lys Ser Ala 25 Asn Lys Glu Leu Val Phe Cys Asn Lys Glu Lys Arg Leu Ile Arg Ser 40 Phe Asp Ala Gin Lys Glu Tyr Gly Ile Thr Pro Val Glu Asn Ile Leu 55 Ser Val Leu Asp Thr Ala Met Asn Pro Asn Ser Ala Leu Val Ile Asp 70 75 Asn Leu Asn Glu Ala Lys Glu Leu His Asp Lys Val Gly Ala Glu Lys 90 Leu Lys Ser Phe Leu Glu Lys Ala Unk Arg Gin Arg Ala Val Leu Arg 100 105 110 His Phe Cys Ala 115 INFORMATION FOR SEQ ID NO:624: SEQUENCE CHARACTERISTICS: LENGTH: 116 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...116 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:624 Leu Lys Val Thr Asn Pro His Leu Leu Val Val Ile Gin Asp Leu Asn 1 5 10 Ala Arg Ile Ala Leu Met Lys Leu Leu Phe Gin Asn Val Lys Ser Ala 25 Asn Lys Glu Leu Val Phe Cys Asn Lys Glu Lys Arg Leu Ile Arg Ser 40 Phe Asp Ala Gin Lys Glu Tyr Gly Ile Thr Pro Val Glu Asn Ile Leu 5 0 55 *Ser Val Leu Asp Thr Ala Met Asn Pro Asn Ser Ala Leu Val Ile Asp 65 70 75 Asn Leu Asn Glu Ala Lys Glu Leu His Asp Lys Val Gly Ala Glu Lys 85 90 Leu Lys Ser Phe Leu Glu Lys Ala Unk Arg Gln Arg Ala Val Leu Arg 1, 00 105 110 SHis Phe Cys Ala 115 INFORMATION FOR SEQ ID NO:625: SEQUENCE CHARACTERISTICS: LENGTH: 237 amino acids TYPE: amino acid TOPOLOGY: l-inear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...237
I
518 (Xi) SEQUENCE DESCRIPTION: SEQ ID NO:625 Val Leu Asn Glii Giu Gin Asn Ser Leu Giu Giu Lys Giy Gly Giu Asn 1i 10 Lys Asn Giu Lys Giu Thr Pro Leu Lys Gly Ile His Ser Lys Ile Pro 25 Ser Leu Lys Gin Ala Leu Giu Gin Thr Ile Ser Lys Ile Lys Ser Ser 40 Lys Giu Phe Phe Lys Gin Leu Leu His Asn Lys Lys Lys Leu Tyr Ile 55 Ala Leu Gly Ile Leu Leu Ser Leu Ile Aia Leu Ile Val Ala Leu Ser 165 70 75 Leu Leu Leu Gly His Lys Lys Glu Asn Lys Gin Thr Ser Leu Gin Thr 90 Asn Thr Ala Thr Thr Asn Asn Giu Thr Pro Asn Asp Thr Asn Asn Ala 100 105 110 Giu Ala Giu Gly Gin Ile Giu Asn Leu Asp Leu Pro Asp Leu Ile Gly 115 120 125 Lys Asp Ser Leu Lys Arg Asn Asp Giu Ser Gin Val Asp Ala Met Met 130 135 140 Gin Lys Ala Ser Leu Leu Tyr Giu Gin Gly Gin Lys Asp Giu Aia Leu 145 150 155 160 His Leu Phe Asp Lys Ile Ala Ser Phe Ser Gin Gly le Ala Ser His 165 170 175 Asn Leu Gly Val Ile Lys Phe Lys Giu Lys Asp Phe Asn Gly Ala Leu 180 185 190 Asp Leu Phe Asp Ser Ser Ile Ala Ser Lys Giu Asn Ala Ser Val Ser 195 200 205 Ala Ile Asp Ala Leu Val Thr Ala Tyr His Leu Gin Asp Ala Asp Leu 210 215 220 Tyr Tyr His Tyr Leu Lys Ile Val Lys Arg His Phe Vai 225 230 235 INFORMATION FOR SEQ ID NO:626: SEQUENCE CHARACTERISTICS: LENGTH: 198 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 198 SEQUENCE DESCRIPTION: SEQ ID NO:626 Met Lys Giu Ser Phe Tyr Ile Giu Gly Met Thr Cys Thr Ala Cys Ser 1 5 10 Ser Gly Ile Giu Arg Ser Leu Giy Arg Lys Ser Phe Val Lys Lys Ile 25 Glu Val Ser Leu Leu Asn Lys Ser Ala Asn Ile Giu Phe Asn Giu Asn 40 Giu Thr Asn Leu Asp Giu Ile Phe Lys Leu Ile Giu Lys Leu Gly Tyr so 55 Ser Pro Lys Lys Thr Leu Ala Giu Giu Lys Lys Giu Phe Phe Ser Pro 70 75 Asn Val Lys Leu Ala Leu Ala Val Ile Phe Thr Leu Phe Val Val Tyr 90 Leu Ser Met Gly Ala Met Leu Ser Pro Ser Leu Leu Pro Giu Ser Leu 100 105 110 Leu Thr Ile Asn His His Ser Asn Phe Leu Asn Ala Cys Leu Gln Leu 115 120 125 Ile Gly Ala Leu Ile Val Met His Leu Gly Arg Asp Phe Tyr Ile Gin 130 135 140 Gly Phe Lys Ala Leu Trp His Arg Gin Pro Asn Met Ser Ser Leu Ile 145 150 155 160 Ala Ile Gly Thr Ser Ala Ala Leu Ile Ser Ala Cys Gly Asn Cys Ile 165 170 175 Trp Phe Ile Pro Ile Ile Ile Pro Ile Ser Gly Leu Met Gly Ile Ile 180 185 190 Ile Leu Lys Ala Cys Ala 195 INFORMATION FOR SEQ ID NO:626: SEQUENCE CHARACTERISTICS: LENGTH: 198 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .198 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:626 Met Lys Giu Ser Phe Tyr Ile Giu Gly Met Thr Cys Thr Ala Cys Ser 1 5 10 *Sen Gly Ile Glu Arg Ser Leu Gly Ang Lys Ser-Phe Val Lys Lys Ile Gl alSn20 25 GluValSerLeu Leu Asn Lys Sen Ala Asn Ile Giu Phe Asn Glu Asn 40 Gl h Asn Leu Asp Giu Ile Phe Lys Leu Ile Giu Lys Leu Gly Tyr 55 Ser Pro Lys Lys Thr Leu Ala Giu Giu Lys Lys Giu Phe Phe Ser Pro 70 75 Asn Val Lys Leu Ala Leu Ala Val Ile Phe Thn Leu Phe Vai Val Tyr 90 Leu Ser Met Giy Ala Met Leu Sen Pro Ser Leu Leu Pro Glu Ser Leu 100 105 110 Leu Thr Ile Asn His His Ser Asn Phe Leu Asn Aia Cys Leu Gin Leu ***115 120 125 Ile Gly Ala Leu Ile Val Met His Leu Gly Ang Asp Phe Tyr Ile Gin 130 135 140 Gly Phe Lys Ala Leu Trp His Arg Gin Pro Asn Met Ser Sen Leu Ile Ala Ile Gly Thn Ser Ala Ala Leu Ile Ser Ala Cys Gly Asn Cys Ile 165 170 175 Trp Phe Ile Pro Ile Ile Ilie Pro Ile Ser Giy Leu Met Gly Ile Ile 180 185 190 Ile Leu Lys 195 Ala Cys Ala INFORMATION FOR SEQ ID NO:62 7 SEQUENCE CHARACTERISTICS: LENGTH: 225 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .225 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:627 Met Asn Thr Ser Leu Leu Tbr Gln Ala Gin Val Leu Ser Ser Lys Glu 1 5 10 Asn Gin Ile His Arg Leu Leu Leu Giu Leu Leu Giu Glu Ala Lys Leu 25 His Phe Glu Pro Lys Leu Tyr Ile Ile Asn Ala Pro Tyr Met Asn Ala 40 Phe Ala Sen Gly Trp Asp Glu Ser Asn Ser Leu Ile Ala Leu Thr Ser so 55 Ala Leu Ile Glu Arg Leu Asp Ang Asp Giu Leu Lys Ala Val Ile Ala 70 75 His Glu Leu Ser His Ile Arg His Asn Asp Ile Arg Leu Thr Met Cys 90 Val Gly Ile Leu Sen Asn Ile Met Leu Leu Val Ala Asn Phe Ser Val 100 105 110 Tyr Phe Phe Met Gly Asn Ang Lys Asn Ser Gly Ala Asn Leu Ala Ang ,115 120 125 Met Ile Leu Trp Val Leu Gin Ile Ile Leu Pro Phe Leu Thr Leu Leu .130 135 140 Leu Gin Met Tyr Leu Sen Arg Thn Arg Giu Tyr Met Ala Asp Ser Gly *145 150 155 160 Ala Ala Phe Leu Met His Asp Asn Lys Pro Met Ile Arg Ala Leu Gin *165 170 175 Lys Ile Ser Asn Asp Tyr Thn Asn Asn Asp Tyr Lys Giu Ile Asp Lys 180 185 190 Asn Ser Thr Arg Ser Ala Ala Tyr Leu Phe Asn Ala Giu Met Phe Ser Thr His Pr S le Lys As r Ile Gin Snr Leu AgLys Ang Vai *210 215 220 Ile 225 INF ORMATION FOR SEQ ID NO:628: SEQUENCE CHARACTERISTICS: LENGTH: 85 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECrJLE.TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori Val 1 Asp Phe Thr Leu Ala (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...85 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:628 Gly Ile Val Pro Asp Asn Leu Trp Lys Leu Lys Arg Phe Asn 5 10 Trp Arg Val Gly Asp Thr Leu Ile Thr Ala Ile Gly Gin Gly 25 Leu Ala Thr Pro Leu Gin Val Leu Ala Tyr Thr Gly Leu Ile 40 Gly Lys Leu Ala Thr Pro His Phe Ala Ile His Asn Gin Gin 55 Lys Asp Pro Leu Asn Arg Phe Ser Lys Lys Glu Ala Pro Ser 70 Arg Gly His Val
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INFORMATION FOR SEQ ID NO:628: SEQUENCE CHARACTERISTICS: LENGTH: 85 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...85 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:628 Val Gly Ile Val Pro Asp Asn Leu Trp Lys Leu Lys Arg Phe Asn 1 5 10 Asp Trp Arg Val Gly Asp Thr Leu Ile Thr Ala Ile Gly Gin Gly 25 Phe Leu Ala Thr Pro Leu Gin Val Leu Ala Tyr Thr Gly Leu Ile 40 Thr Gly Lys Leu Ala Thr Pro His Phe Ala Ile His Asn Gin Gin 50 55 Leu Lys Asp Pro Leu Asn Arg Phe Ser Lys Lys Glu Ala Pro Ser 65 70 Ala Arg Gly His Val INFORMATION FOR SEQ ID NO:629: SEQUENCE CHARACTERISTICS: LENGTH: 496 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .496 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:629 *0 Met 1 Leu Asn Val Ile Ala Lys Val Asn Asp 145 Gly Gly Ile Thr Ala 225 Ile Tyr Asp Phe Tyr 305 Gly Asp Ala Leu Ile 385 Ala Asp Ile Leu Leu Gly Leu Tyr Ala Phe 130 Ser Gly Ser Trp Ile 210 Asp Ile Ile Ile Val 290 Ala Leu Leu Val Gin 370 Ile Phe Trp Val Lys Thr Ala Ser Leu Thr 115 Gly Val Vai Ile Leu 195 Ala Ala Ile Val Ser 275 Gly Gly Ala Val Phe 355 Val Met Ser Phe Pro Ile Asn Ser Thr Asn 100 Ala Trp Leu Glu Thr 180 Ile Met Ala Gly Phe 260 Asn Gly Phe Gly Leu 340 Ser Ala Arg Gly Lys 420 5 Asn Tyr Lys Gly Pro Thr Ile Asn Asp Asp 165 Ala Gly Leu Val Gin 245 Gly Gly Thr Gly Ala 325 Asn Asn Gly Ile Ile 405 Asp Trp Gin Ser Ser 70 Leu Leu Gln Ala Asn 150 Asn Gin Lys Ala Leu 230 Gly Ile Ile Leu Tyr 310 Phe Tyr Val Ile Ser 390 Val Ser Leu Thr Phe 55 Gly Ala Gly Gly Leu 135 Leu Val Ala Glu Phe 215 Pro Ser Phe Gin Phe 295 Leu Gly Thr Gly Ser 375 Thr Phe Met Lys Val 40 Ala Lys Thr Pro Phe 120 Ile Sen Lys Ser Phe 200 Ala Ala Tyr Val Ile 280 Lys Tyr Leu Val Asn 360 Leu Val Pro Lys Ala 25 Tyr Asp Ser Sen Leu 105 Ala Asn Asn Gly Thr 185 Thr Ala Tyr Leu Phe 265 Asn Met Lys Asn Asn 345 Asn Phe Val Ile Asn 10 Ile Cys Ile Ser Leu 90 Trp Leu Lys Lys Asn 170 Asn Ala Leu Gly Asp 250 Ile Ile Ala Ile Gin 330 Ser Ala Ala Val Ala 410 Ile Asp Met Leu Gly 75 Ala Gly Thr Asn Ile 155 Ile Ile Asn Glu Vai 235 Phe Sen Gly Met Ser 315 Val Ile Pro Ile Lys 395 Val Leu Leu Leu Thr Gin Ala Ser Pro Ile 140 Gin Leu Thr Lys Ser 220 Val Val Phe Phe Val 300 Tyr Leu Leu Sen Pho 380 Pro Cys Ile Pro Ile Gly Gly Ser Ala Sen 125 Asp Asn Leu Ala Leu 205 Val Asn Ser Met Glu 285 Sen Ser Phe Pro Leu 365 Met Leu Leu Trp Ile Pro Tyr Va1 Asn Trp 110 Ser Va1 Phe Gin Asp 190 Gin Val Leu Tyr Lys 270 Tyr Phe Ile Trp Ala 350 Leu Gin Ile Ile Phe Val Sen Thr Ile Leu Ala Gly Ser Thr Ile 175 Gly Asn Lys Pro Leu 255 Leu Met Ile Tyr Ala 335 Val Gin Val Ala Val 415 Ile Ser Tyr Sen Glu Val Ser Cys Met Lys 160 Ile Leu Asn Gly Asp 240 Ile Arg Arg Ala Phe 320 Leu Arg Gly Thr Gly 400 Leu Asn Phe Asn Ile Lys Arg Thn Phe Lou Ile Thr Ile Ile Ser Phe Pho *s.
425 430 Asn Lou Phe Ile Lou Val Lou Ala Ile Pro Ile Lou Lou Phe Gly Val 435 440 445 Leu Ala Leu Leu Ala Phe Asn Leu Thr Ile Thr Pro Ser Val Ala Ile 450 455 460 Gin Asn Ile Asn Gln Gly Gly Leu Gly Ile Asp Ser Thr Ile Ala Ser 465 470 475 480 Leu Ile Thr Leu Phe Ile Leu Lys Gly Phe Ile Glu Thr Ile Ile Glu 485 490 495 INFORMATION FOR SEQ ID NO:630: SEQUENCE CHARACTERISTICS: LENGTH: 142 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...142 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:630 Met Ala Phe Trp Gin Ala Ile Arg Trp Trp Ile Leu Lys Leu Pro Phe 1 5 10 Met Met Gly Ala Thr Met Met Trp Ile Leu Ser Glu Met Ala Phe Lys 25 Ile Ala Gly Unk Met Ala Phe Lys Glu Ala Ser Arg Ala Ala Asn Pro 40 0 Val Leu Leu Glu Pro Met Met Lys Val Glu Val Glu Val Pro Glu Glu 50 55 S Tyr Met Gly Asp Val Ile Gly Asp Leu Asn Arg Arg Arg Gly Gin Ile 70 75 Asn Ser Met Asp Asp Arg Leu Gly Leu Lys Ile.Val Asn Ala Phe Val P 85 90 Pro Leu Val Glu Met Phe Gly Tyr Ser Thr Asp Leu Arg Ser Ala Thr 100 105 110 Gin Gly Arg Gly Thr Tyr Ser Met Glu Phe Asp His Tyr Gly Glu Val 115 120 125 Pro Ser Asn Ile Ala Lys Glu Ile Val Glu Lys Arg Lys Gly 130 135 140 9 9 INFORMATION FOR SEQ ID NO:631: SEQUENCE CHARACTERISTICS: LENGTH: 153 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1. 153 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:631 Met Gin Asn Leu Pro dly Met Ala Arg Ala Ala Met Leu Thr Thr Ser 1 5 10 Ser Ala Pro Ala Pro Giu Gly Giu Gly Ala Phe Arg Ala Met Lys Met 25 Ala Ser Glu Met Ala Lys Val Giu Val Gly Tyr Val Asn Ala His Gly 40 Thr Ser Thr His Tyr Asn Asp Trp Tyr Glu Ser Ile Ala Leu Lys Asn 55 Val Leu Ala Leu Lys Lys Lys Ser'Leu Leu Leu Ala Pro Leu Lys Gly 70 75 Axg Leu Gly Leu Leu Gly Cys Cys Gly Val Arg Ser Arg Tyr Ser Ile 90 Met Ala Met Unk Gin Gly Ile Leu Pro Pro Thr Ile Asn Gln Glu Thr 100 105 110 Pro Asp Pro Glu Cys Unk Leu Asp Tyr Ile Pro Asn Thr Ala Arg Glu 115 120 125 Lys Gin Val Asn Ala Val Met Ser Asn Ser Phe Gly Phe Gly Gly Thr 130 135 140 Asn Gly Val Val Ile Phe Lys Lys Ala 145 150 INFORMATION FOR SEQ ID NO:632: SEQUENCE CHARACTERISTICS: LENGTH: 343 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori.
(ix) FEATURE: NAIAE/KE": misc_feature LOCATION 1 .343 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:632 Met Gin Asn Leu Leu Ile Gin Ala Giu Asn Ala Ile Ala Leu Leu Phe 1 5 10 Leu Leu Asn Asp Lys Asn Leu Lys Gly Lys Ile Asp Leu Ile Tyr Ile 25 Asp Pro Pro Phe Ala Thr Asn Asn His Phe Thr Ile Thr Asn Gly Arg 40 Ala Tbz Thr Ile Ser Asn Ser Lys Asn Gly Asp Ile Ala Tyr Ser Asp so. 55 Lys Val Val Gly Met Asp Phe Met Glu Phe Leu Lys Gin Arg Leu Val 70 75 Leu Leu Lys Giu Leu Leu Ser Glu Gin Gly Ser Ile Tyr Val His Thr 90 Asp Tyr Lys Ile Gly His Tyr Vai Lys Val Met Leu Asp Giu Ile Phe 100 105 .110 Gly Ile Gin Asn Phe Mrg Asn Giu Ile Thr Arg Ile Lys Cys Asn Pro 115 120 125 Lys Asn Phe Lys Mrg Ile Gly Tyr Gly Asn Ile Lys Asp Met Ile Leu 130 135 140 Phe Tyr Ser Lys Gly Lys Asn Pro Ile Phe Asn Giu Pro Lys Ile Pro 525 145 150 155 160 Tyr Thr Pro Gin Asp Leu Glu Lys Arg Phe Pro Lys Ile Asp Lys Asp 165 170 175 Lys Arg Arg Tyr Thr Thr Val Pro Ile His Ala Pro Gly Giu Val Glu 180 185 190 Ser Gly Glu Cys Ser Lys Ala Phe Lys Giy Met Leu Pro Pro Lys Gly 195 200 205 Arg His Trp Arg Thr Asp Ile Ala Thr Leu Giu Arg Trp Asp Lys Giu 210 215 220 Gly Leu Ile Giu Tyr Ser Asn Asn Asn Asn Pro Arg Lys Lys Ile Tyr 225 230 235 240 Ala Leu Giu Gin Val Gly Lys Arg Val Gin Asp Ile Trp Glu Phe Lys 245 250 255 Asp Pro Gin Tyr Pro Ser Tyr Pro Thr Giu Lys Asn Ala Gin Leu Leu 260 265 270 Asp Leu Ile Ile Lys Thr Ser Ser Asn Lys Asp Ser Ile Val Leu Asp 275 .280 285 Cys Phe Cys Gly Ser Gly Thr Thr Leu Lys Ser Ala Phe Leu Leu Gin 290 295 300 Arg Lys Phe Ile Gly Ile Asp Asn Ser Asp Leu Ala Ile Gin Ala Cys 305 310 315 320 Lys Asn Lys Leu Giu Thr Ile Thr Lys Asp Leu Phe Val Ser Gin Asn 325 330 335 Phe Tyr Asp Phe Leu Val Phe 340 INFORMATION FOR SEQ ID NO:632: SEQUENCE CHARACTERISTICS: LENGTH: 343 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: S. NAME/KEY: misc..feature LOCATION .343 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:632 Met Gin Asn Leu Leu Ile Gin Ala Glu Asn Ala Ile Ala Leu Leu Phe 1 5 10 Leu Leu Asn Asp Lys Asn Leu Lys Gly Lys Ile Asp Leu Ile Tyr Ile 25 Asp Pro Pro Phe Ala Thr Asn Asn His Phe Thr Ile Thr Asn Gly Arg *5*35 40 Ala Thr Thr Ile Ser Asn Ser Lys Asn Gly Asp Ile Ala Tyr Ser Asp so 55 Lys Val Val Gly Met Asp Phe Met Giu Phe Leu Lys Gin Arg Leu Val 70 75 Leu Leu Lys Glu Leu Leu Ser Giu Gin Gly Ser Ile Tyr Val His Thr 90 Asp Tyr Lys Ile Gly His Tyr Val Lys Val Met Leu Asp Giu Ile Phe 100 105 110 Gly Ile Gin Asn Phe Arg Asn Glu Ile Thr Arg Ile Lys Cys Asn Pro 115 120 125 Lys Asn Phe Lys Arg Ile Gly Tyr Gly Asn Ile Lys Asp Met Ile Leu 130 135 140 526 Phe Tyr Ser Lys Gly Lys Asn Pro Ile Phe As n Giu Pro Lys Ile Pro 145 Lys Ser Arg Gly 225 Ala Asp Asp cys Arg 305 Lys 150 Thr Arg Gly His 210 Leu Leu Pro Leu Phe 290 Lys Asn Pro Arg Glu 195 Trp Ile Giu Gin Ile 275 Cys Phe Lys Gin Tyr 180 Cys Arg Glu Gin 260 Ile Gly Ile Leu Asp 165 Thr Ser Thr Tyr Val1 245 Pro Lys Ser dly Glu 325 Leu Thr Lys Asp Ser 230 Gly Ser Thr Gly Ile 310 Thr Val Giu Val1 Ala Ile 215 Asn Lys Ser Thr 295 Asp Ile Phe Lys Pro Phe 200 Ala As n Arg Pro Ser 280 Thr Asn Thr Arg Phe 170 Ile His 185 Lys Gly Thr Leu Asn Asn Val Gin 250 Thr Giu 265 Asn Lys Leu Lys Ser Asp Lys Asp 330 155 Pro Ala Met Glu Pro 235 Asp Lys Asp Ser Leu 315 Leu Lys Pro Leu Arg 220 Arg Ile Asn Ser Ala 300 Ala Phe Ile G ly Pro 205 Trp Lys Trp Ala Ile 285 Phe Ile Val1 Asp Glu 190 Pro Asp Lys Glu Gin 270 Val1 Leu Gin Ser Lys 175 Val1 Lys Lys Ile Phe 255 Leu Leu Leu Ala Gin 335 Asp G bo Gly Glu Tyr 240 Lys Leu Asp Gin Cys 320 Asn Phe Tyr Asp Phe Leo 340 fee* 0 6 INFORMATION FOR SEQ ID NO:633: SEQUENCE CHARACTERISTICS: LENGTH: 93 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 93 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:633 Met Ile Leo Lys Asn Leu Ile Leo Leu Phe Leu 1 5 10 Ile Phe Ile Glu Ala Asn Phe Tyr Thr Ile Ser -25 Glu Val Ala Arg Sen Tyr Gin Asp Leu Ala Leu 40 Pro Asn Tyr Ciu Phe Ile Tnp Ile Thn Asp Gly 50 Ala Lys Sen Lys Leo Gin Glu Ala Tyr Lys Sen' 70 75 Leo Ser Tyn Val Asn Asp Phe Ile Sen Lys Val Lys Arg Lys Leo Ser Lys Leo Asn Phe Glu Ala Phe Gly Tnp Leu Asp Gl Ile Tyn Asn Lyso 99 9 9 999 9 INFORMATION FOR SEQ ID NO:634: SEQUENCE CHARACTERISTICS: LENGTH: 176 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...176 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:634 Met Thr Ser Val Val Ile Lys Pro His Ala Tyr Gly Glu Gin Val Gin 1 5 10 Glu Ile Glu Glu Glu Ser Asp Ser Asp Tyr Glu Lys Asn Asn Asp Gin 25 Glu Ala Ile Asn Phe Gly Ile Ala Leu His Lys Gly Leu Glu Tyr Gin 40 Tyr Ala Tyr Asn Ile Pro Lys Gin Ser Val Leu Glu Tyr Leu Asn Tyr 55 His Tyr Gly Phe Tyr Gly Leu Asp Tyr Gin Ala Leu Glu Glu Ser Leu 70 75 Glu Leu Phe Glu Asn Asp Ala Gly Ile Gin Ala Leu Phe Lys Asn His 90 Ala Leu Lys Gly Glu Ala Ala Phe Leu Phe Gln Gly Val Val Ser Arg 100 105 110 Ile Asp Val Leu Leu Trp Asp Arg Gly Gin Asn Leu Tyr Val Leu Asp 115 120 125 Tyr Lys Ser Ser Gin Asn Tyr Gin Gin Ser His Lys Ala Gin Val Ser 130 135 140 His Tyr Ala Glu Phe Leu Arg Thr Gin Unk Pro His Phe Lys Ile Gin 145 150 155 160 Ala Gly Ile Ile Tyr Ala His Lys Arg Leu Leu Glu Lys Unk Trp Unk 165 170 175 INFORMATION FOR SEQ ID NO:634: SEQUENCE CHARACTERISTICS: LENGTH: 176 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: S* NAME/KEY: misc_feature LOCATION 1...176 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:634 Met Thr Ser Val Val Ile Lys Pro His Ala Tyr Gly Glu Gin Val Gin 1 5 10 Glu Ile Glu Glu Glu Ser Asp Ser Asp Tyr Glu Lys Asn Asn Asp Gin 25 528 Glu Ala Ile Asn Phe Gly Ile Ala Leu His Lys Gly Leu Glu Tyr Gln 40 Tyr Ala Tyr Asn Ile Pro Lys Gin Ser Val Leu Glu Tyr Leu Asn Tyr 55 His Tyr Gly Phe Tyr Gly Leu Asp Tyr Gin Ala Leu Glu Glu Ser Leu 70 75 Glu Leu Phe Glu Asn Asp Ala Gly Ile Gin Ala Leu Phe Lys Asn His 90 Ala Leu Lys Gly Glu Ala Ala Phe Leu Phe Gin Gly Val Val Ser Arg 100 105 110 Ile Asp Val Leu Leu Trp Asp Arg Gly Gin Asn Leu Tyr Val Leu Asp 115 120 125 Tyr Lys Ser Ser Gin Asn Tyr Gin Gin Ser His Lys Ala Gin Val Ser 130 135 140 His Tyr Ala Glu Phe Leu Arg Thr Gin Unk Pro His Phe Lys Ile Gin 145 150 155 160 Ala Gly Ile Ile Tyr Ala His Lys Arg Leu Leu Glu Lys Unk Trp Unk 165 170 175 INFORMATION FOR SEQ ID NO:635: SEQUENCE CHARACTERISTICS: LENGTH: 88 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: 0* NAME/KEY: misc_feature LOCATION 1...88 0 0 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:635 Met Glu Ser Gin Leu Met Lys Leu Ala Ile Glu Thr Tyr Lys Ile Thr S1 5 10 Leu Met Ile Ser Leu Pro Val Leu Leu Ala Gly Leu Val Val Gly Leu 25 Leu Val Ser Ile Phe Gin Ala Thr Thr Gin Ile Asn Glu Met Thr Leu 35 40 SSer Phe Val Pro Lys Ile Leu Ala Val Ile Gly Val Leu Ile Leu Thr 50 55 Met Pro Trp Met Thr Asn Met Leu Leu Asp Tyr Thr Lys Thr Leu Ile 70 75 Lys Leu Ile Pro Lys Ile Ile Gly INFORMATION FOR SEQ ID NO:636: SEQUENCE CHARACTERISTICS: LENGTH: 115 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES
I
529 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...115 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:636 Met Lys Phe Phe Thr Arg Ile Thr Asp Ser Tyr Lys Lys Val Val Val 1 5 10 Thr Leu Gly Leu Val Val Thr Thr Asn Pro Leu Met Ala Val Thr Ser 25 Pro Ala Thr Gly Val Thr Glu Thr Lys Ser Leu Val Ile Gin Ile Ile 40 Ser Val Leu Ala Ile Val Gly Gly Cys Ala Leu Gly Val Lys Gly Ile 55 Ala Asp Ile Trp Lys Ile Ser Asp Asp Ile Lys Arg Gly Gin Ala Thr 70 75 Val Phe Ala Tyr Ala Gin Pro Ile Ala Met Leu Ala Val Ala Gly Gly 90 Ile Ile Tyr Leu Ser Thr Lys Phe Gly Phe Asn Ile Gly Glu Ser Gly 100 105 110 Gly Ala Ser 115 INFORMATION FOR SEQ ID NO:637: SEQUENCE CHARACTERISTICS: LENGTH: 260 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...260 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:637 Met Ser Glu Asp Leu Pro Phe Ala Ser Asp Ser Gin Phe Thr Tyr Asn 5 10 Gly Val Ser Ile Thr Arg Pro Thr Asn Glu Val Asn Asp Val Ile Ser 25 Gly Val Asn Ile Thr Leu Glu Gin Thr Thr Glu Pro Asn Lys Pro Ala 40 Ile Ile Ser Val Ser Arg Asp Asn Gin Ala Ile Ile Asp Ser Leu Lys 55 Glu Phe Val Lys Ala Tyr Asn Glu Leu Ile Pro Lys Leu Asp Glu Asp 70 75 Thr Arg Tyr Asp Ala Asp Thr Lys Ile Ala Gly lie Phe Asn Gly Val 90 Gly Asp Ile Arg Ala Ile Arg Ser Ser Leu Asn Asn Val Phe Ser Tyr 100 .105 110 Ser Val His Thr Asp Asn Gly Val Glu Ser Leu Met Lys Tyr Gly Leu 115 120 125 Ser Leu Asp Asp Lys Gly Val Met Ser Leu Asp Glu Ala Lys Leu Ser 130 135 140 Leu Ser Lys Leu 195 Lys Met Gin Lys Asn Lys Phe 180 Lys Asp Ala Lys Asn 260 Ser Asp 165 As n Ile Lys Giu Phe 245 As n 150 Met Gin Tyr Giu Arg 230 As n Pro Giy Val1 Giu Asn 215 Phe Ser Lys Gly Ile Asp 200 Ala Ala Val1 Ala Arg Ala 185 Ser Gin Ala Gin Thr Giu 170 Asn Leu Giu Tyr Met 250 530 Gin Asp 155 Ile His Leu Ile Asp Arg Leu Leu 220 Asp Ser 235 Met Ile 0 INFORMATION FOR SEQ ID NO:637: SEQUENCE CHARACTERISTICS: LENGTH: 260 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein iiii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .260 (xi) SEQUENCE DESCRIPTION: SEQ ID N0:637 1Met Ser Giu Asp Leu Pro Phe Ala Ser Asp Ser'
GI
Gly Ile Giu 65 Thr Gly Sen Ser Ser 145 Ser Phe Ala Val Ser Val Asn 35 Ile Ser s0 Phe Val Arg Tyr Asp Ile Val His 115 Leu Asp 130 Ala Leu Asp Sen Sen Lys Lys Leu Ile 20 Ile Val Lys Asp Arg 100 Thr Asp As n Lys Phe 180 Lys 5 Thr Thr Ser Ala Ala Ala Asp Lys Ser Asp 165 Asn Ile Arg Leu Arg Tyr 70 Asp Ile Asn Gly Asn 150 Met Gin Pro Giu Asp 55 Asn Thr Arg Gly Val 135 Pro Gly Val1 Glu Thr Gin 40 Asn Giu Lys Sen Val 120 Met Lys Gly Ile Asp Asn 25 Thr Gin Leu Ile Sen 105 Giu Sen Ala Arg Ala 185 Sen Giu Thn Ala Ile Ala 90 Leu Ser Leu Thr Giu 170 Asn Leu Val Giu Ile Pro 75 Gly Asn Leu Asp Gin 155 Ile Leu Asp Gin Asn Pro Ile Lys Ile Asn Met Giu 140 Asp His Ile Arg Phe Asp Asn Asp Leu Phe Val Lys 125 Ala Phe Gin Asp Asp 205 Thr Val Lys Ser Asp Asn Phe 110 Tyr Lys Phe Giu dly 190 Ala Tyr Ile Pro Leu Giu Gly Ser Gly Leu Tyr Gly 175 Gly Lys Asn Sen Aia Lys Asp Val Tyr Leu Ser Gly 160 Ile Asn Ser 195 200 Leu Thr Lys Asp Lys Giu Asn Ala Gin Giu Leu Leu Lys Thr Arg Tyr 210 215 220 Asn Ile Met Ala Glu Arg Phe Ala Ala Tyr Asp Ser Gin Ile Ser Lys 225 230 235 240 Ala Asn Gin Lys Phe Asn Ser Val Gin Met Met Ile Asp Gin Ala Ala 245 250 255 Ala Lys Lys Asn 260 INFORMATION FOR SEQ ID NO:638: SEQUENCE CHARACTERISTICS: LENGTH: 191 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...191 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:638 Met Lys Asn Pro Gin Ala Asn Val Leu Lys Leu Phe Leu Asn Gin Val S 1 5 10 Ala Asp Gin Lys Tyr Ile Asp Met Asn Asp Glu Lys Asn Tyr Asp Pro 25 Arg Glu Pro Glu Pro Pro Tyr Gly Thr Lys Gly Ala Leu Asp Glu Ile 35 40 Ile Arg Thr Asp Ala Arg Ser Trp Ala Asn Thr Pro Asp Asp Glu Phe 55 Gly Ser Ile Met Ser Ser Phe Lys Arg Phe Met Tyr Val Tyr Lys Asp S 65 70 75 Pro Lys Val Arg Glu Ala Thr Ser Lys Met Ser Ehe Asp Tyr Glu Glu 85 90 Leu Arg Thr Gly Asn Ile Ser Ile Tyr Ile Val Ile Ala Gin Ile Asp 100 105 110 Ile Gly Thr Leu Ser Ser Leu Val Arg Ala Phe Leu Glu Ser Ile Ala 115 120 125 Lys Asn Leu Met Val Lys Glu Ser Ser Lys Pro Glu Glu Arg Ile Phe 130 135 140 Ile Ile Ala Asp Glu Phe Val Arg Phe Gly Lys Leu Pro Phe Leu Leu 145 150 155 160 Glu Met Pro Ala Leu Cys Arg Ser Tyr Asn Val Val Pro Leu Phe Ile 165 170 175 Thr Gin Asp Tyr Ala Met Ile Arg Asn Thr Ile Ala Met Met Ile 180 185 190 INFORMATION FOR SEQ ID NO:639: SEQUENCE CHARACTERISTICS: LENGTH: 351 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES
II
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .351 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:639 Met Ile Ser Giu Ile Ile Lys Phe Gin Leu Lys Gly Ile Lys Met Ile
C
CC
C C. C, 1 Arg L Val L Asp C Thr I Sen C Ile I Ile 2 Lys Phe 145 Gin Asp Lys Phe Ser 225 Gly His Asn Asn Phe 305 Glu Ile *eu ,eu ;lu 00 .eu ly ?he ksn lu 130 31u rhr Asp Ala Gly 210 Thr Glu Ser Met Met 290 Phe Cys Gl) Lys Leu Asp Thr Trp Glu Lys uis Ile Met Met Trp Leu 195 Glu Tyr Asn Ser Ile 275 Glu
GI
Ile 11( 5 Gly L Gly ;z Leu I Ser C Asn I Cys 100 Glu Lys Lys Leu His Gly Arg Asp Asp Asn 260 Glu Ile Lys Lys Vai 340 .eu la ~eu :ys .eu lal %sp Glu lu lu 165 Glu Ile Ser Thr Tyr 245 Asn Leu Asr Ala Asr 32E Tr Asn i Thr Lys 1 Asn 2 70 Sen I Glu Thr Lys His 150 Asn Arg Lys Tyr Arg 230 Lys Ile Thr Giy L Lys 310 i Lys Lys jys la ~rg Ua -ys .lu lu Ala 135 Ser Ala Phe Glu Ile 215 Gin Ile Lys Asr Sei 29 Va Va Thr L Pro 1 40 Val I Lys Glu Glu I Asp 120 Lys Lys Phe Gly Tyr 200 Arg Thr Thr Pro Ile 280 Lys i Pro 1 Lys jeu 55 Jeu ~ys la1 Phe Lys 105 Lys Val Glu Asp Gly 185 Ser Gin Leu Trp Leu 265 Lys Tyl G1 Sei 10 Lys 'I Met I Leu I Asp Pro 90 His Glu Leu Phe Asn 170 Ile Asp Tyr Ser Leu 250 Met Lys Pro i Thr r Tyr 330 :hr iis Sly 75 Gln Lys lu Arg Pro 155 Gly Sen Glu Lys Aid 235 Lys Sen Glu Ile Trp 315 Asr Sen Lys Asn Ser Glu Gin Leu Gin 140 Asn Ala Arg Gly Lys 220 Met Pro Asr SHi~ SArc Asi Leu I Pro I Ile I Gin Tyr Ala Ala 125 Lys Lys Glu Glu Lys 205 Asp Ala Lys Thr Vai 285 Lys Asn n Thr jeu .eu -ys Tyr Arg Leu 110 Lys Phe Lys Ser Asn 190 Ile Phe Asn Tyz Gl.
27( Met Asi Ly Th: Ala G Leu S Glu A Leu Glu I Asn I Lys Met Gin Phe 175 Thn Leu Glu Met Gin 255 a Leu Gly p Trp s Ile r Ala 335 ly er ~sp Lsn ,ys 'eu Ile kla Leu 160 Ile Tyr Ala Glu Sen 240 Leu Leu Cys Gly Trp 320 Glu Lys Asn Thr 345 Tyr Ser Ile Sen His His 350 INFORMATION FOR SEQ ID NO:640: SEQUENCE CHARACTERISTICS: LENGTH: 351 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .351 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:640 a a. a a.
a Met Val Pro Ser Arg Ile S er Giy Ile Giu 145 Val1 Pro Ala His Ser 225 Asn Val
LYS
Val Leu 305 Giu Leu Ala Asp Gin Lys Asn Gin Leu Gly Asp 130 Phe Met Thr Gin Ser 210 Ile Ser Ser Giu Ala 290 Ala Val Glu Giu Arg Giu Leu Leu Pro Thr 115 Ang Ser Gin Ile Asn 195 Arg Leu Lys Val Met 275 Asn Ser Val Giu Asn Sen Gin Se r His Sen 100 Gly Leu Asp Ile Asp 180 Giu Gly Ser Lys Asp 260 Leu Asp Val Tyr Gin 340 Val1 Val1 Leu Ser Ser Pro Val1 Leu Ile Leu 165 Ala Ile Met Lys S er 245 Met Asp Giu Gly Ser 325 Arg Asp Thr Arg Gin 70 Vai Thr Leu Gly Giu 150 Lys Lys Ser Met Met 230 Ang Met Leu Val1 Phe 310 Glu Ilie Leu Ser 55 Vali Asp Ser Giu Gly 135 Leu Giu Giu Ile Asn 215 Gly Asn Val1 Asp Ser 295 Gin Lys Gin Tyr 40 Phe Ser Gin Phe Ile 120 Lys Asn Vai Ser Met 200 Ile Ser Lys Phe Val 280 Val Gly Glu Asn 25 Asp Arg Ser Met As n 105 Asn G ly Leu Trp Ser 185 Vali Cys Arg Giu Leu 265 Gly Tyr Arg 10 Val1 Phe Ser Ile Thr 90 Val1 Pro Sen Leu S er 170 Ala Val Tyr Asp Leu 250 Gly Asp Val Arg Thr 330 Trp, Gin Lys Ile Met 75 Tyr Phe Ser Ala Asp 155 Pro Asn Leu Pro Phe 235 Gin Ala Thr His Lys 315 Lys Ala Lys Arg His Arg Gly Sen Ile Tvr 140 Thr Val Val1 Giu Val1 220 Met Ala Val1 Ile Lys 300 Thr Giu Met Lys Pro Asp S en G iu Met Ala 125 Asp Ile Val1 Val1 Ile 205 Ile Leu Leu G lu Arg 285 Lys Ile Ile Leu Asp As n Lys Ile Phe Lys 110 Phe Gin Leu G lu Gin 190 Ile Ser Sen Leu Leu 270 Leu Lys Gin Leu Trp 350 Ile Arg Met Val1 Leu Pro Pro A sn Arg Met 175 Ile Ile Ile Giu Ser 255 Sen Asn Arg Ile Giu 335 Ser Ile Val Aia Giu Met Met Met Arg Gin 160 Tyr Val1 Gly Giu Thr 240 Giy Leu Lys Tyr Lys 320 Met Asp Ilie Leu Ser Gin Giu Giu Ile Asp Ala Leu Leu Giu Val Ang Arg Gin Ser 345 INFORMATION FOR SEQ ID NO:641: SEQUENCE CHARACTERISTICS: LENGTH: 145 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...145 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:641 Met Arg Ile Val Phe Met Gly Thr Pro Ser Phe Ala Glu Val Ile Leu 1 5 10 Arg Ala Leu Val Glu Asn Glu Asp Lys Lys Ile Glu Val Val Gly Leu 25 Phe Thr Gin Arg Asp Lys Pro Phe Gly Arg Lys Lys Glu Leu Lys Ala 40 Pro Glu Thr Lys Thr Tyr Ile Leu Glu Asn His Leu Asn Ile Pro Ile 55 Phe Gin Pro Gin Ser Leu Lys Glu Pro Glu Val Gin Ile Leu Lys Gly 70 75 Leu Lys Pro Asp Phe Ile Val Val Val Ala Tyr Gly Lys Ile Leu Pro 90 Lys Glu Val Leu Thr Ile Ala Pro Cys Ile Asn Leu His Ala Ser Leu 100 105 110 Leu Pro Lys Tyr Arg Gly Ala Ser Pro Ile His Glu Met Ile Leu Asn A 115 120 125 Asp Asp Arg Ile Tyr Gly Ile Ser Thr Met Leu Met Unk Phe Gly Ile 130 135 140 Gly 145 INFORMATION FOR SEQ ID NO:641: SEQUENCE CHARACTERISTICS: LENGTH: 145 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...145 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:641 Met Arg Ile Val Phe Met Gly Thr Pro Ser Phe Ala Glu Val Ile Leu 1 5 10 Arg Ala Leu Val Glu Asn Glu Asp Lys Lys Ile Glu Val Val Gly Leu 25 Phe Thr Gin Arg Asp Lys Pro Phe Gly Arg Lys Lys Glu Leu Lys Ala 40 Pro Glu Thr Lys Thr Tyr Ile Leu Glu Asn His Leu Asn Ile Pro Ile 55 Phe Gin Pro Gin Ser Leu Lys Glu Pro Glu Val Gin Ile Leu Lys Gly .70 75 Leu Lys Pro Asp Phe Ile Val Val Val Ala Tyr Gly Lys Ile Leu Pro Lys Leu Asp G ly 145 90 Glu Val Leu Thr Ile Ala Pro Cys Ile Asn Leu His Ala Ser Leu 100 105 110 Pro Lys Tyr Arg Gly Ala Ser Pro Ile His Glu Met Ile Leu Asn 115 120 125 Asp Arg Ile Tyr Gly Ile Ser Thr Met Leu Met Unk Phe Gly Ile 130 135 140 INFORMATION FOR SEQ ID NO:642: ti) SEQUENCE CHARACTERISTICS: LENGTH: 190 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1 190 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:642 Pro Thr Met Leu Ala Val Gly Phe Trp Val 10
S
5* S 5 Met Leu Val Phe Leu Sen 15 Thr Val Ala Asp Phe Asp Val Ile Lys 145 Ser Pro Gly 50 Val Gly Ser Ser Glu 130 Lys Asn Ala Val Asn Leu Thr Asp Gly Leu Asp 20 25 Ser Asn Gly Phe G ly His 115 Thr Arg Ile Ala Glu Leu Ser 100 Asn Leu Leu Phe G lu Leu Trp Leu Giu Ser Phe Git 165 Thr Phe Phe 70 Tyr Ala Ile *Val *Leu 150 Asn Leu Ser 55 Val1 Asn Ile Leu Ile 135 Met Lys Leu 40 Lys Ile Cys Gly Leu 120 Leu Ala Val1 Tyr Ser Asn Gly 105 Val Gln Pro Ile Leu 185 Leu Ser Ile Leu Leu Leu Ala 75 Pro Ala 90 Phe Ile Leu Met Val Gly Ile His 155 Val Arg Tyr Leu Ser Ala Gly Ser 140 His Phe Pro Val1 Val1 Tyr Sen 125 Tyr His Val1 Lys Gly Phe As n 110 Ile Lys Phe Tyr Val1 Sen Met Ala Phe Thr G iu Val Ile Leu G ly Ile Val1 Arg Gin Lys Gly Trp Ala Phe Trp Ile Met Leu Ser Asn 180 Leu Val Ala Leu Sen Leu Lys Val Ile Ser 175 INFORMATION FOR SEQ ID NO:64 3 SEQUENCE CHARACTERISTICS: LENGTH: 489 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .489 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:643 Val Arg Phe Giu Asn Phe Ile Asn Arg Leu Ala Phe Tyr Met Ala Thr 1 5 10 Gly Ser Gly Lys Thr Ile Val Ile Ile Lys Leu Val Giu Leu Leu Sen 25 Val Ala Met Gly Met Gly Leu Ile Pro Lys Lys Asn Ile Met Phe Phe 40 4S Ser Ala Asn Glu His Leu Ile Lys Gin Phe Giu Lys Glu Ile Giu Lys 55 Tyr Asn Arg Asn Lys Asp Tyr Sen Lys Gin Ile Asp Phe Lys Asn Leu 70 75 Lys Sen Val Lys Asn Lys Asp Phe Tyr Arg Ala Pro Lys Asp Sen Leu 90 Met Lys Giu Ile Ala Leu Phe Tyr Tyr Arg Ala Asp Leu Met Sen Asp 100 105 110 Giu Glu Ser Lys Giu Asn Leu Leu Asn Tyr Lys Asp Cys Tnp Asp Asn 115 120 125 Giy Glu Asn Tyr Val Ile Leu Asp Glu Ala His Lys Gly Asn Lys Thr *Gu130 135 140 GuSer Lys Arg Gin Ala Ile Phe Ser Leu Leu Sen Leu Lys Gly Phe 145 150 155 160 :Leu Phe Asn Phe Sen Ala Thr Phe Thr Giu Giu.Sen Asp Leu Ile Thr *165 170 175 Ala Val Tyr Asn Leu Sen Vai Giy Giu Trp Val Lys Leu Gly Tyr Gly 180 185 190 *Lys Giu Ser Val Leu Leu Lys Lys Asn Asn Leu Asn Ala Phe Lys Glu LuLs195 200 205 e y Asp Leu Asn Asp Arg Giu Lys Glu Ile Ala Leu Leu Lys Ala 210 215 220 Leu Leu Leu Leu Gly Met Gin Lys Ang Tyr Lys Val Glu Gly Tyr Phe 225 230 235 240 His Asp Pro Leu Met Leu Val Phe Thr His Ser Val Asn Met Giu Asn 245 250 255 Ser Asp Ala Unk Ile Phe Phe Lys Thr Leu Ala Arg Val Ile Giu Asn 260 265 270 Asp Asp Giu Ser Asp Phe Ser Lys Ala Lys Asp Asp Leu Leu Giu Giu 275 280 285 Leu Lys Asn Pro Giu Phe Leu Phe Ser Asp dly Lys Asp Lys Giu Lys 290 295 300 Asp Tyr Lys Ile Giu Val Phje Lys Giu Sen Leu Lys Gly Met Asp Phe 305 310 315 320 Lys Gly Leu Lys Giu Ala Val Phe Tyr Ala Ser Asn Gly His Ile Giu 325 330 335 Val Ile Ile Asn Pro Lys Asn Asn Gin Giu Ile Ala Phe Lys Leu Asn 340 345 350 Tbr Ser Asp Lys Val Phe Cys Leu Ile Arg Ile Giy Asp Ile Thr Giu 355 360 365 Trp Ile Arg Giu Lys Leu Lys Ser Val Lys Val Val Sen Lys Asn Leu 370 375 380 Sen Phe Lys Giu Glii Ser Tyr Phe Ser Gin Ile Asp Lys Sen Ser Ile 385 390 395 400 Asn Ile Leu Val Gly Ser Arg Ala Phe Asp Thr Gly Trp Asp Sen Thr 405 ,410 415 Arg Pro Ser Val Ile Leu Phe Leu Asn Ile Gly Leu Asp Asp Asp Ala Lys Val Ile 465 Cys 420 425 430 Lys Leu Val Lys Gin Ser Phe Gly Arg Gly Val Arg Ile Glu Ser 435 440 445 Lys Asn Gin Arg Gin Arg Leu Ala Tyr Leu Glu Ile Asp Glu Ala 450 455 460 Lys Glu Gin Ala Glu Thr Lys Arg Cys Asn Ala Gly Asn Ala Phe 470 475 480 Asp Thr Tyr Gin Pro Cys Lys Pro 485 INFORMATION FOR SEQ ID NO:644: SEQUENCE CHARACTERISTICS: LENGTH: 248 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...248 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:644 9 99. 9 Met Arg Phe Tyr Phe Lys Phe Leu Trp Leu Leu 1 Phe Val Gin Arg Arg Pro Ser Val Leu 145 Ile Glu Asp Phe Ala 225 Val Tyr Lys Ala 50 Leu Leu Thr Leu Ser 130 Asn Gly Leu Gin Val 210 Val Phe Phe Ser Tyr Ile Asn Phe Asn 115 His Gly Gin Val Val 195 Gly Leu Leu Leu Ala Phe Leu Ser Met 100 Pro Asn Phe Asn Val 180 Leu Glu Lys Ser 5 Asp Leu Phe Glu Ile 85 Thr Ile Gin Leu Gin 165 Asp Thr Val Asn Gly 245 Ile Met Gln Ala 70 Tyr Ser Val Ala Asn 150 Val Phe Ser Ser Ala 230 Val 10 Lys Gly Ser Ser Ser 25 Ser Ala Lys Asn Ser 40 Ala Gin Asn Ile Lys 55 Leu Lys Leu Glu Asri 75 Pro Leu Glu Asn Pro 90 Phe Ile Asn Leu Glu 105 Asn Leu Glu Glu Asn 120 Ile Gly Ile Ala Val 135 Ala His Lys Arg Cys 155 Leu Gly Phe Ile Gly 170 Ile Val Pro Ser Ala 185 Gly Leu Asp Gly Ile 200 Ser Val Glu Asp His 215 Phe Leu Ser Glu Ala 235 SLys Asn Gly Tyr Leu Glu Ala Lys Asp Lys Leu 140 Ala Thr Glu Phe Tyr 220 Ile Ile Leu Phe Asp Met Thr Ile 125 Glu Tyr Asn Ile Gly 205 Thr ?he Ser Asp Gln Leu Thr His 110 Tyr Lys Ser Phe Asn 190 Ala Tyr Leu Asp Asn Lys Lys Tyr Ser Gly Gly Val Lys 175 Ile Gly Lys Ile Arg Val Glu Glu Thr Val Leu Arg Met 160 Gin Gly Val Ser Lys Leu Leu Arg INFORMATION FOR SEQ ID NO:644: SEQUENCE CHARACTERISTICS: LENGTH: 248 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .248 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:644 9* Met Phe Val Gin Arg Arg Pro Ser Val Leu 145 Ile Giu Asp Phe Ala 225 Val Phe Ser Ile Asn Phe Asn 115 His dly Gin Val1 Val 195 Gly Leu Leu Leu Ala Phe Leu Ser Met 100 Pro Asn Phe Asn Val 180 Leu Glu Lys Ser Asp Leu Phe Giu Ile 85 Thr Ile Gin Leu Gin 165 Asp Thr Val Asn Gly 245 Ile Met Gin Aia 70 Tyr Ser Val Ala Asn 150 Val Phe Ser Ser Ala 230 Val Lys Ser Ala 55 Leu Pro Phe Asn Ile 135 Ala Leu Ile Gly Ser 215 Phe Lys Gly Ala 40 Gin Lys Leu I le Leu 120 Gly His G ly Val Leu 200 Val Leu Asn Ser Lys Asn Leu Giu As n 105 Glu Ile Lys Phe Pro 185 Asp Glu Ser Ser As n I le G lu Asn Leu Glu Ala Arg Ile 170 Ser Gly Asp Glu Ser Tyr Ser Leu Lys Glu Asn Ala Pro Lys Glu Asp Asn Lys Val Leu 140 Cys Ala 155 Gly Thr Ala Glu Ile Phe His Tyr 220 Ala Lys 235 Ile Leu Phe Asp Met Thr I le 125 Glu Tyr As n Ile G ly 205 Thr Leu Arg Phe Tyr Phe Lys Phe Leu Trp Leu Leu Gly Ile Phe Leu Ile INFORMATION FOR SEQ ID NO:645: SEQUENCE CHARACTERISTICS: LENGTH: 119 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...119 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:645 Leu Ala Leu Arg Leu Pro Phe Leu Ile Ala His Val Ile Asn Met Phe 1 5 10 Leu Phe Tyr Leu Ile Gly Arg Lys Ile Leu Lys Lys Pro Lys Asp Ala 25 Leu Tyr Val Val Leu Thr Tyr Ala Leu Leu Pro Gly Val Asn Leu Phe 40 Ala Ile Leu Leu Ala Lys Ser Val Leu Val Leu Ser Leu Gly Leu Leu 55 Ile Ser Tyr Leu Tyr Ile Lys Thr Gin Lys Ile Pro Tyr Leu Thr Leu 70 75 Ser Ala Cys Ala Phe Leu Asp Gly Ala Phe Ile Pro Leu Leu Leu Gly 90 Val Phe Ala Tyr Ala Leu Arg Lys Thr Ala Ile Leu Arg Ala Arg Ser 100 105 110 Leu Leu Trp Trp Phe Unk Leu 115 INFORMATION FOR SEQ ID NO:645: SEQUENCE CHARACTERISTICS: LENGTH: 119 amino acids TYPE: amino acid S(D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES S(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...119 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:645 Leu Ala Leu Arg Leu Pro Phe Leu Ile Ala His Val Ile Asn Met Phe 1 5 10 Leu Phe Tyr Leu Ile Gly Arg Lys Ile Leu Lys Lys Pro Lys Asp Ala 25 Leu Tyr Val Val Leu Thr Tyr Ala Leu Leu Pro Gly Val Asn Leu Phe 40 Ala Ile Leu Leu Ala Lys Ser Val Leu Val Leu Ser Leu Gly Leu Leu 55 Ile Ser Tyr Leu Tyr Ile Lys Thr Gin Lys Ile Pro Tyr Leu Thr Leu 70 75 Ser Ala Cys Ala Phe Leu Asp Gly Ala Phe Ile Pro Leu Leu Leu Gly 90 Val Phe Ala Tyr Ala Leu Arg Lys Thr Ala Ile Leu Arg Ala Arg Ser 100 105 110 Leu Leu Trp Trp Phe Unk Leu 115 INFORMATION FOR SEQ ID NO:646: SEQUENCE CHARACTERISTICS: LENGTH: 108 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...108 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:646 Val Asn Leu Met Asp Tyr Phe Ser Lys Ser Leu Phe Leu Asn Ser Leu 1 5 10 Asn Thr Gin Arg Leu Ile Val Ser Asn Lys Leu Ala Ile Asp Val Gin 25 Tyr Gly Met Leu Gin Ser Val Arg Lys Asn Tyr Pro Asp Val Val Asp 40 Gly Gly Val Arg Glu Gly Pro Phe Trp Val Leu Ala Gly Ala Leu Met 50 55 Pro Ser Ile Leu Ile Glu Ile Gly Tyr Asn Ser His Ala Ile Glu Ser S 65 70 75 Lys Arg Ile Gin Ser Lys Pro Tyr Gln Lys Ile Leu Ala Lys Gly Ile 90 Ala Asp Gly Ile Asp Ser Phe Phe Ser Lys Asn Asp 100 105 INFORMATION FOR SEQ ID NO:646: SEQUENCE CHARACTERISTICS: LENGTH: 108 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: nisc_feature LOCATION 1...108 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:646 Val Asn Leu Met Asp Tyr Phe Ser Lys Ser Leu Phe Leu Asn Ser Leu 1 5 10 Asn Thr Gin Arg Leu Ile Val Ser Asn Lys Leu Ala Ile Asp Val Gin 25 Tyr Gly Met Leu Gin Ser Val Arg Lys Asn Tyr Pro Asp Val Val Asp 40 Gly Gly Val Arg Glu Gly Pro Phe Trp Val Leu Ala Gly Ala Leu Met 55 Pro Ser Ile Leu Ile Glu Ile Gly Tyr Asn Ser His Ala Ile Glu Ser 541 75 Axg Ile Gin Ser Lys Pro Tyr Gin Lys Ile Leu Ala Lys Gly Ile 90 Asp Gly Ile Asp Ser Phe Phe Ser Lys Asn Asp 100 105 INFORMATION FOR SEQ ID NO:647: SEQUENCE CHARACTERISTICS: LENGTH: 213 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES ivi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .213 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:647 woo* 0.0 0 of a 0 00.
00 00*0 S.0.
00 SV Val 1 Trp Phe Thr 65 Phe Ala Asp Asn 145 Trp Gly Ser Val Phe Val Thr Phe Gly Sen Ser Cys Val 130 Ile Leu Leu Leu Sen 210
LYS
Leu Leu 35 Gin Phe Thr Asn Phe 115 Phe Ala Asn Ser Leu 195 Pro Asn Ser Leu Phe Gly Ile Ser Ile Sen Met Leu Ile Thr Thr 20 Thr Ile Leu Thr Ala 100 Cys Sen Tyr Ala Phe 180 Met Thr 5 Ala His Leu Ala Phe Pro Ala Ala Ala Lys 165 Alr Ala Cys Pro Gly Asp 70 Gly Sen Gly Lys Ile i5o Ala Ile Pro Ile Leu Asn Phe 40 Leu Val 55 Lys Ile Phe Phe Leu Val Ile Met 120 Ile Arg 135 Thr Ala Ile Ala Leu Ile Ile Tyr 200 Ile 25 His Gly Lys Gdy Asn 105 Asn Phe Gly Val Val 185 His 10 Phe Phe Ile Pro Phe 90 Thr Phe Ser Phe Pro 170 Ser Lys Ile Thr Val His 7S Leu Ile Cys Gly Thr 155 Glu Leu Ser Leu Pro Ser Lys Phe -Il1e Pro Ile 140 Pro Ser Ile Asn Phe Phe Sen Val1 Phe Leu Ile 125 Ser Gin Leu Ala Thr 205 Val1 Glu Ile Cys Lys Tyr 110 Phe Phe Leu Gin Phe 190 Gin Pro Lys Ile Met G lu Phe Met Ala Sen Sen 175 Ile His Asn Thr Phe Ala Phe Leu S en Tyr Sen 160 Tyr Thn Glu INFORMATION FOR SEQ ID NO:648: SEQUENCE CHARACTERISTICS: LENGTH: 157 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein 0 0 (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...157 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:648 Leu Ala Ser Arg Tyr Ser Val Ala Val Gly Asn Leu Phe Ser Glu His 1 5 10 Leu Tyr Asp Leu Arg Asn Glu Thr Met Thr Asn Leu Ile Gly Phe Leu 25 Leu Val Leu Ala Ser Ile Trp Val Phe Phe Leu Ala Leu Gly Val Leu 40 Leu Gly Lys Met Leu Val Phe Ser Gly Leu Gly Ile Ile Asp Lys Ala 55 Leu Gly Phe Ile Phe Ser Cys Leu Lys Thr Phe Leu Val Leu Ser Phe 70 75 Ile Leu Tyr Ala Leu Ser Lys Met Asp Leu Met Lys Asp Ala Asn Ala 90 Tyr Leu Gin Glu Lys Unk Unk Ile Phe Pro Thr Unk Lys Unk Unk Unk 100 105 110 Ser Lys Ile Met Arg Leu Asp Gly Val Lys His Val Glu Lys Asn Leu 115 120 125 Lys Asp Asn Leu Glu Glu Met Ser Asp Glu Val Lys Asn Lys Gly Ser 130 135 140 Ile Asp Asn Ala Lys Glu Ser Phe Asn Lys Gly Tyr Gly 145 150 155 INFORMATION FOR SEQ ID NO:648: SEQUENCE CHARACTERISTICS: LENGTH: 157 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...157 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:648 Leu Ala Ser Arg Tyr Ser Val Ala Val Gly Asn Leu Phe Ser Glu His 1 5 10 Leu Tyr Asp Leu Arg Asn Glu Thr Met Thr Asn Leu Ile Gly Phe Leu 25 Leu Val Leu Ala Ser Ile Trp Val Phe Phe Leu Ala Leu Gly Val Leu 40 Leu Gly Lys Met Leu Val Phe Ser Gly Leu Gly Ile Ile Asp Lys Ala 55 Leu Gly Phe Ile Phe Ser Cys Leu Lys Thr Phe Leu Val Leu Ser Phe ,70 75 Ile Leu Tyr Ala Leu Ser Lys Met Asp Leu Met Lys Asp Ala Asn Ala 90 Leu Gin Giu Lys Unk Unk Ile Phe Pro Thr Unk Lys Unk Unk Unk 100 105 110 Lys Ile Met Arg Leu Asp Giy Vai Lys His Val Giu Lys Asn Leu 115 120 125 Asp Asn Leu Giu Giu Met Ser Asp Giu Val Lys Asn Lys Gly Ser 130 135 140 Asp Asn Ala Lys Giu Ser Phe Asn Lys Giy Tyr Giy 150 INFORMATION FOR SEQ ID NO:649: SEQUENCE CHARACTERISTICS: LENGTH: 312 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: CA) ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .312 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:649 Met 1 Leu Tyr Phe Gly 65 Ala Val Giu Ser Lys 145 Asn Lys Ser Asp Lys Pro Phe Leu Giu Arg Tyr Phe Tyr Asp Leu Gin Lys 50 Lys Val Ser Ala Giu 130 Ile Ala Gin Cys 35 Ile Thr Val Val1 Tyr 115 Lys Val1 Leu Lys Ile Pro Pro Ser Lys 100 Leu Arg Phe Leu Leu 180 Thr Lys Alz Alz 5 GlyI Ala Ile Phe Arg 85 Gly.
Leu Giu Leu Lys 165 Giu Arg Phe SPro ,eu Ile Phe Ala Leu Tyr L'hr Ilie Ilie 70 G1y Asn Aia Leu Asp 150 Pro Arg Asp Met Leu 230 Phe Ile Ser 55 Leu Tyr Ile Leu C iy 135 Asp Lys Giu Lys Leu 215 Pro Asp 25 L~ys Ile .,iu Gin Leu Asn 120 Va 1 G ly Val1 As n Asp 200 Leu Lys Leu Arg Lys Thr Giy Asn Leu Ile Ala Pro 75 Arg Asp Sen 90 Val Pro Gin 105 Leu Lys Gin Leu Lys Aia Phe Arg Phe 155 Pro Pro Tyr 170 Ile Lys Sen 185 Tyr Gin Arg Val Thr Ala Glu Val Vai 235 Lys Leu Leu 250 ?ro k1a Ile Arg Lys Lys Ala Leu 140 Asn Tyr Tyr Ile Ile 220 Lys Phe Lys Ala Tyr Giy Thr Ser 125 Glu Phe Pro Lys Thr 205 Ala Lys Ser Lys Giy Gin Leu Ala 110 Val Leu Asn Phe Giu 190 Ser Asn Leu jeu -[is Gly Glu V/al Gly Ile Gly Gin Cys 175 Ala Ile Pro Tyr Pro Thr Ile Asp Ser Val1 Val Asp Val Ser Phe 160 Leu His Thr Ser Phe 240 Pro Ser Giy Leu Asn Arg 225 Arg Val Pro 210 Leu Asp Ile 195 Thr Asp His 245 Gin Asn Asn Gin An Asn Thr Ser Leu Leu Val 265 Thr Ser Giu Lys Glu Lys Asp Leu 270 Phe Tyr 255 Val Lys Leu Gin Asp Cys Lys Leu Pro Leu Ser Val Leu Asp Leu Lys Leu Glu 275 280 285 Ile Cys Pro Lys Val Leu Glu Glu Ile Asp Arg Tyr Ile Leu Ser Tyr 290 295 300 Pro Cys Asn Ile Lys Glu His Leu 305 310 INFORMATION FOR SEQ ID NO:650: SEQUENCE CHARACTERISTICS: LENGTH: 56 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...56 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:650 Met Ser Leu Gly Ala Val Ile Arg Leu Ile Phe Cys Tyr Lys Leu Glu 1 5 10 Gly Val Ile Leu Asp Leu Lys Arg Ile Asn Phe Lys Ser Tyr Tyr Pro 25 Asn Asn Lys Asn Ala Leu Phe Ile Asn Asn Lys Lys Asn Pro Leu Ser 40 Ser Thr Ser Lys Phe Ile Leu Leu 50 INFORMATION FOR SEQ ID NO:651: SEQUENCE CHARACTERISTICS: LENGTH: 199 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...199 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:651 Met Leu Glu Thr Thr Ile Asp Phe Ser Arg Tyr Ser Ser Val Lys Ile 1 5 10 Gly Ala Pro Leu Lys Val Ser Val Leu Glu Asn Asp Asn Glu Ile Ser 25 Gin Glu His Gin Ile Ile Gly Leu Ala Asn Asn Leu Leu Ile Ala Pro 40 Asp Val Lys Asn Leu Ala Leu Leu Gly Lys Asn Tyr Asp Tyr Ile Cys 545 55 Asp Lys Gly Glu Trp Val Glu Val Gly Gly Ala Ala Asn Ala Ser Lys 70 75 Ile Phe Asn Tyr Phe Arg Ala Asn Asp Leu Glu Gly Leu Glu Phe Leu 90 Gly Gin Leu Pro Gly Thr Leu Gly Ala Leu Val Lys Met Asn Ala Gly 100 105 110 Met Lys Glu Phe Glu Ile Lys Asn Val Leu Glu Ser Ala Cys Val Asn 115 120 125 Gly Glu Trp Leu Glu Lys Glu Ala Leu Gly Leu Asp Tyr Arg Ser Ser 130 135 140 Gly Phe Asn Gly Val Val Leu Arg Ala Arg Phe Lys Lys Thr His Gly 145 150 155 160 Phe Arg Glu Gly Val Leu Lys Ala Cys Lys Ser Met Arg Lys Ser His 165 170 175 Pro Lys Leu Pro Asn Phe Gly Ser Cys Phe Lys Asn Pro Pro Asn Asp 180 185 190 Tyr Ala Gly Arg Leu Leu Glu 195 INFORMATION FOR SEQ ID NO:652: SEQUENCE CHARACTERISTICS: LENGTH: 81 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...81 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:652 Leu Ser Lys Gin Ser Ala Asp Ile Val Ile Thr Asn Asp Ser Leu Ser 1 5 10 Ser Leu Val Lys Val Leu Ala Ile Ala Lys Lys Thr Lys Ser Ile Thr 25 Trp Gin Asn Ile Leu Phe Ala Leu Gly Ile Lys Ala Val Phe Ile Val 40 Leu Gly Leu Met Gly Val Ala Ser Leu Trp Glu Ala Val Phe Gly Asp 55 Val Gly Val Thr Leu Leu Ala Leu Ala Asn Ser Unk Arg Thr Met Arg 65 70 75 Ala S* INFORMATION FOR SEQ ID N0:652: SEQUENCE
CHARACTERISTICS:
LENGTH: 81 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...81 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:652 Leu Ser Lys Gin Ser Ala Asp Ile Val Ile Thr Asn Asp Ser Leu Ser 1 5 10 Ser Leu Val Lys Val Leu Ala Ile Ala Lys Lys Thr Lys Ser Ile Thr 25 Trp Gln Asn Ile Leu Phe Ala Leu Gly Ile Lys Ala Val Phe Ile Val 40 Leu Gly Leu Met Gly Val Ala Ser Leu Trp Glu Ala Val Phe Gly Asp 55 Val Gly Val Thr Leu Leu Ala Leu Ala Asn Ser Unk Arg Thr Met Arg 70 75 Ala INFORMATION FOR SEQ ID NO:653: SEQUENCE CHARACTERISTICS: LENGTH: 89 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...89 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:653 Met Leu Lys Asn Gly Asp Lys Ile Pro Asp Ala Ile Leu Val Asp Ile 1 5 10 Glu Met Pro Lys Met Asp Gly Tyr Thr Phe Ala Ser Glu Val Arg Lys 25 Tyr Asn Lys Phe Lys Asn Leu Pro Leu Ile Ala Val Thr Ser Arg Val 35 40 Thr Lys Thr Asp Arg Met Arg Gly Val Glu Ser Gly Met Thr Glu Tyr 50 55 Ile Thr Lys Pro Tyr Ser Gly Glu Tyr Leu Thr Thr Val Val Lys Arg 70 75 Ser Ile Lys Leu Glu Gly Asp Gin Ser INFORMATION FOR SEQ ID NO:654: SEQUENCE CHARACTERISTICS: LENGTH: 111 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...111 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:654 Val Phe Glu Pro Val Ile Ala Tyr Lys Leu Phe His Ser Phe Val Ile 1 5 10 Leu Gly Cys Ala Ile Glu Thr Leu Thr Thr Lys Cys Val Glu Gly Ile 25 Thr Ala Asn Glu Lys Ile Cys His Asp Tyr Val Phe Asn Ser Ile Gly 40 Ile Val Thr Ala Leu Asn Pro His Ile Gly Tyr Glu Lys Ser Ala Met 55 Ile Ala Lys Glu Ala Leu Lys Ser Asp Arg Ser Ile Tyr Asp Ile Ala 70 75 Leu Glu Lys Lys Ile Leu Thr Lys Glu Gin Leu Asp Asp Ile Phe Lys 90 Pro Glu Asn Met Leu Arg Thr His Ala Phe Lys Lys His Lys Asp 100 105 110 INFORMATION FOR SEQ ID NO:655: SEQUENCE CHARACTERISTICS: LENGTH: 65 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...65 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:655 Met Leu Arg Leu Leu Ala Gin Lys Ser Ala Ile Lys Leu Ile Leu Ile 1 5 10 Pro Pro Ser Ala Asn Ala Leu Gly Ile Ala Ser Ile Cys Glu Leu Ser 25 Glu Glu Val Phe Glu His Glu Lys Ile Val Gly Ile Arg Ala Gin Gly 40 Asp Phe Thr Ile Asn Ser Asp Asp Arg Gly Phe Trp Glu Arg Arg Cys 50 55 Gin INFORMATION FOR SEQ ID NO:656: SEQUENCE CHARACTERISTICS: LENGTH: 268 amino acids
I
Le Gl Se Th As
G
G
1
V
TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: trpll ORGANISM: Helicobacepyo (ix) FEATURE- NAME/KEY: miscjfeature LOCATION .268 (xi) SEQUENCE DESCRIPTION: SEQ ID No:656 t Lys Lys Leu Leu Leu Leu Leu Giu H-is Lys Ile Val Li 2.0 u Ile Ile Val Ile Val Leu Val Gly Phe Phe Leu PheT 25 3 u Ile Lys Giu Lys Ala Val Asn Val Ser Gin Gly Lys P 40 45 r Ser Tyr Leu Phe Gin Ala Tyr Giu Giy Ile Lys Asn 55 60 "r Ile Asn Gin Val Lys Pro Asn Asp Glu Thr Lys Ser 70 75 n Ile Glu Lys Thr Gin Lys Asp Leu Asp Asp Phe Asn2 85 90 .n Lys Leu Pro Asn Leu Pro Lys Asp Phe Asn Lys Thr 1.00 2.05 :o Gin Ser Pro Phe Phe Asn Tyr Asn Thr Ala Asn Giu 115 2.20 1.25 sn Arg Leu Val Ile Leu Ala Ser Arg Ile Ser Sen Gin 130 135 2.40 in Pro Pro Ile Ser Ile Lys Asn Ser Val Ser His Ile 45 2.50O 155 lu Lys Arg Giu Leu Glu Lys Giu Trp Ala Lys Pro Ser 165 170 ly Ser Phe Ser Leu Leu Ser Ser Sen Sen Ser Phe Ser 180 185 ral Ser Phe Leu Ser Arg Gly Ile Gly Leu Asp Cys Giu 195 200 205 er Phe Leu Lys Ala Phe Sen Ser Ser Leu Phe Ser Leu 210 215 220 eu Phe Cys His Pro Leu Sen Leu Phe Cys Ser Leu Ile Z25 230 235 Phe Cys Phe Ser Lys Phe Ser Arg Giu Leu Val Asn Ala 245 250 Sen Leu Giu Phe Sen Ser Leu Ser Arg Leu Gly Sen 260 265 INF7ORMATION FOR SEQ .ID NO:65 7 SEQUENCE
CHARACTERISTICS:
LENGTH: 1.00 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori yr 0 'he ,ys Pal kla Leu 110 Lys Lys Va Se: 19' Ly Le Gi Se le Gly Giu Gin Pro Thr le Asp Asn Giu Leu Val le Lys Giu Lys Giu Thr Ser Lys 2.60 1Ser Phe 2.75 r Phe Gilu 0 s Leu Lys u Sen Ser y Leu le 240 r Asn Asn 255 9 9.
9* 9. 9 0 9 (ix) FEATURE: rAEKy: miscfeature LOCATION .100 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:6S 7 Met Gly Ala Ile Ala Ser cys Tyr Ala His Gin Ile Ile Leu Thr Ser 1 5 10 Asp Asn Pro Arg Ser Giu Asn Giu Giu Asp Ile Ile Lys Asp Ile Leu 25 Lys Gly Ile Asn Asn Ser Ser Lys Val Ile Val Giu Lys Asp Arg Lys 3S 40 Lys Ala Ile Leu Asn Ala Leu Giu Asn Leu Lys Asp Asp Giu Val Leu so 55 Leu Ile Leu Giy Lys Gly Asp Glu Asn Ile Gin Ile Phe Lys Asp Lys 70 75 Thr Ile Phe Phe Ser Asp Gin Giu Val Val Lys Asp Tyr Tyr Leu Asn 85 90 Leu Lys Gin Giy 100 INFORMATION FOR SEQ ID NO:658: SEQUENCE
CHARACTERISTICS:
LENGTH: 80 amino acids TYPE: amino acid TOPOLOGY: iinear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Heiicobacter pylori
FEATURE:
NAME/KEY: misc feature LOCATION (xi) SEQUENCE DESCRIPTION: SEQ ID NO:6S 8 *Val Met Asp Lys Leu Thr Lys Ser Leu Gin Thr Gin Lys Asn Phe Ala 1 5 10 Tyr Leu Gly Lys Ile Lys Pro Gin Gin Leu Ala Asp Phe Ile Ile Asn 25 Glu His Pro Gin Thr Ile Ala Leu Ile Leu Ala His Met Glu Unk Pro .935 40 Asn Ala Ala Giu Thr Leu Ser Tyr Phe Pro Asp Glu Met Lys Ala Giu 55 0 Ile Ser Ile Arg Met Ala Asn Phe Arg Arg Asn Ile Aia Pro Sen Gly o 99 65 70 75 INFORMATION FOR SEQ ID NO:659: SEQUENCE
CHARACTERISTICS:
LENGTH: 205 amino acids TYPE: ami.no acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION (xi) SEQUENCE DESCRIPTION: SEQ ID NO:6S9 Met Arg Tyr Phe Arg Ser Ala Phe Leu Leu Phe Phe Met Thr Leu Phe 1 5 10 15 Phe Val Ser Cys Ser Lys His Pro.Phe Ser Lys Gin Thr Pro Lys Thr 25 Lys Glu Arg Ile Arg Gin Giu Giu Ala Asn Lys Lys Arg Giu Giu Thr 40 Leu Asn Ala Leu Arg Gin Phe Arg Leu Ile Tyr Ile Asn Thr Pro Val s0 55 Phe Arg Phe Tyr Asp Tyr Giy Thr Ile Lys Thr Asp Lys Asp His Asn 70 75 Thr Glu Val Thr Leu Tyr Lys Leu Ser Gin Lys Val Giy Asp Ile Tyr 90 Met Thr Lys Arg Ser Ile Cys Phe Ser Gin Lys Cys Ser Ala Lys Trp 100 105 110 Ile Ala Ala Arg Asp Leu Phe Gly Lys Val Ser Tyr Gly Asp Leu Phe 115 120 125 Asp Asp Ile Val Leu Gly Arg Asp Ile Phe Lys Gly Leu Gly Lys Arg 130 135 140 His Leu Thr Pro Giu Tyr Val Ile Gin Arg Phe Gin Lys Ser Gly Giu 145 150 155 160 Ile Ilie Leu Tyr Giu Arg Lys Asn Gly Leu Ile Ser Phe Gin Asn Leu 165 170 175 Thr Gin Lys Ilie Ala Ile Arg Ile Giu Pro Tyr Giu Pro Ser Leu Gin 180 185 190 Asp Leu Glu Asp Asn Giu Asn Ala Asp Ser Giu Leu Gin 195 200 205 INFORMATION FOR SEQ ID NO:660: SEQUENCE CHARACTERISTICS: LENGTH: 124 amino acids (B)TYP: ainoacid TOPOLOGY: linear 0* (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc_feature LOCATION .124 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:660 Met Arg Ile Giu Giu Asn Giy Vai Ile Sen Leu Ala Phe Ser Asn Gly 1 5 10 Val Val Giu Pro Val Ala Arg Ile Giy Ile Unk Aia Phe Thr Asn Asp 25 Gin Gly Leu Arg Lys Ile Gly Gly Asn Leu Tyr Giu Met Gin Giu Gly 40 Tbr Ile Asn Giy Giu Asn Arg Pro Leu Unk Gly Asn Pro Ile Leu Gly Trp Leu Leu Asp Asp Glu Met Asp 551 Glu Glu Gly Lys Leu Lys Phe Gly Lys Ile Arg His Lys Tyr 70 75 Thr Ser Asn Val Asn Ala Gly Asn Ala Leu Thr Asn Leu Ile 90 Gin Arg Gly Tyr Ser Met Asn Ala Arg Ala Phe Gly Ala Gly 100 105 110 Met Ile Lys Glu Ala Ile Ser Leu Lys Lys 115 120 INFORMATION FOR SEQ ID NO:661: SEQUENCE CHARACTERISTICS: LENGTH: 93 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...93 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:661 Val Glu Ala Arg Tyr Tyr Tyr Gly Asp Thr Ser Tyr 1 5 10 Val Gly Val Leu Gin Glu Phe Ala His Phe Gly Ser 25 Ser Leu Asn Thr Phe Lys Ile Asn Ala Ala Arg Ser 35 40 Tyr Ala Arg Ala Met Met Gly Gly Glu Leu Gin Leu 55 Phe Leu Asn Leu Gly Val Val Tyr Leu His Asn.Leu 70 Ser His Phe Ala Ser Asn Leu Gly Met Arg Tyr Ser INFORMATION FOR SEQ ID NO:662: SEQUENCE CHARACTERISTICS: LENGTH: 80 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...80 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:662 Phe Tyr Leu Asn Asp Val Pro Leu Ser Ala Lys Glu Ile Ser Asn Phe 552 Met Lys Asn Leu Arg His Phe Arg Lys Leu Ile Ala Phe Leu Gly Phe 1 5 10 Ser Pro Leu Leu Leu Gin Ala Asp Met Thr Thr Phe Phe Asn Ser Ile 25 Glu Gin Gin Leu Thr Ser Pro Thr Ala Lys Gly Ile Leu Met Val lle 40 Phe Leu Gly Leu Ala Ile Phe Ile Trp Lys Asn Leu Asp Arg Trp Lys 55 Glu Ile Leu Met Thr Val Leu Ala Leu Lys Unk Val Pro Met Gin Unk 70 75 INFORMATION FOR SEQ ID NO:662: SEQUENCE CHARACTERISTICS: LENGTH: 80 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...80 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:662 Met Lys Asn Leu Arg His Phe Arg Lys Leu Ile Ala Phe Leu Gly Phe 1 5 10 Ser Pro Leu Leu Leu Gin Ala Asp Met Thr Thr-Phe Phe Asn Ser Ile 25 Glu Gin Gin Leu Thr Ser Pro Thr Ala Lys Gly Ile Leu Met Val Ile 35 40 S* Phe Leu Gly Leu Ala Ile Phe Ile Trp Lys Asn Leu Asp Arg Trp Lys 55 Glu Ile Leu Met Thr Val Leu Ala Leu Lys Unk Val Pro Met Gin Unk S: 65 70 75 INFORMATION FOR SEQ ID NO:663: SEQUENCE CHARACTERISTICS: LENGTH: 214 amino acids o TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...214 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:663 Val Glu Glu Leu Ala Lys Leu Ile Asn Asn Asn Asn Asn Asn Lys Lys 1 5 10 Leu Arg Gly Phe Phe Leu Lys Val Leu Leu Ser Leu Val Val Phe Ser 25 Ser Tyr Gly Ser Ala Asn Asp Asp Lys Glu Ala Lys Lys Glu Ala Leu 40 Glu Lys Glu Lys Asn Thr Pro Asn Gly Leu Val Tyr Thr Asn Leu Asp 55 Phe Asp Ser Phe Lys Ala Thr Ile Lys Asn Leu Lys Asp Lys Lys Val 70 75 Thr Phe Lys Glu Val Asn Pro Asp Ile Ile Lys Asp Glu Val Phe Asp 90 Phe Val Ile Val Asn Arg Val Leu Lys Lys Ile Lys Asp Leu Lys His 100 105 110 Tyr Asp Pro Val Ile Glu Lys Ile Phe Asp Glu Lys Gly Lys Glu Met 115 120 125 Gly Leu Asn Val Glu Leu Gin Ile Asn Pro Glu Val Lys Asp Phe Phe 130 135 140 Thr Phe Lys Ser Ile Ser Thr Thr Asn Lys Gin Arg Cys Phe Leu Ser 145 150 155 160 Leu His Gly Glu Thr Arg Glu Ile Leu Cys Asp Asp Lys Leu Tyr Asn 165 170 175 Val Leu Leu Ala Val Phe Asn Ser Tyr Asp Pro Asn Asp Leu Leu Lys 180 185 190 His Ile Ser Thr Ile Glu Ser Leu Lys Lys Ile Phe Tyr Thr Ile Thr 195 200 205 Cys Glu Ala Val Tyr Leu 210 INFORMATION FOR SEQ ID NO:664: SEQUENCE CHARACTERISTICS: LENGTH: 78 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...78 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:664 Val Gly Gly Ile Val Ala Asn Met Asn Asp Leu Ser Thr Tyr Met Val 1 5 10 Glu Asn Leu Leu Met Gly Leu Tyr Leu Phe Ser Ser Ala Leu Asp Leu S* 20 25 Gly Val Lys Lys Ala Ile Asn Leu Ala Ser Ser Cys Ala Tyr Pro Lys 40 Tyr Ala Pro Asn Pro Leu Lys Glu Ser Asp Leu Leu Asn Gly Ser Leu 55 Glu Pro Thr Asn Glu Gly Tyr Ala Leu Pro Asn Ser Leu Unk 70 INFORMATION FOR SEQ ID NO:665: SEQUENCE CHARACTERISTICS: LENGTH: 177 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...177 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:665 Met Lys Lys Arg Lys His Val Ser Lys Lys Val Phe Asn Val Ile Ile 1 5 10 Leu Phe Val Ala Val Phe Thr Leu Leu Val Val Ile His Lys Thr Leu 25 Ser Asn Gly Ile His Ile Gin Asn Leu Lys Ile Gly Lys Leu Gly Ile 40 Ser Glu Leu Tyr Leu Lys Leu Asn Asn Lys Leu Ser Leu Glu Val Glu 55 Arg Val Asp Leu Ser Ser Phe Phe His Gin Lys Pro Thr Lys Lys Arg 70 75 Leu Glu Val Ser Asp Leu Ile Lys Asn Ile Arg Tyr Gly Ile Trp Ala 90 Val Ser Tyr Phe Glu Lys Leu Lys Val Lys Glu Ile Ile Leu Asp Asp 100 105 110 Lys Asn Lys Ala Asn Ile Phe Phe Asp Gly Asn Lys Tyr Glu Unk Arg S115 120 125 lie Ser Arg Asn Gin Arg Gly Ile Phe Pro Arg Arg Arg Leu Lys Ile 130 135 140 Ser Ser Leu Lys Ser Ser Ile Cys Phe Leu Lys Met Leu Lys Ser Lys S* 145 150 155 160 *00 Trp Met Ala Thr Pro Thr Ile Unk Pro Lys Pro Gly Lys Trp Arg Ser .165 170 175 Ile .o INFORMATION FOR SEQ ID NO:666: SEQUENCE CHARACTERISTICS: LENGTH: 258 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...258 (xi) SEQUENCE DESCRIPTION: SEQ ID N0:666 Val Ser Cys Trp Gly Ala Ser Lys Lys Arg Phe Leu Gly Phe Cys Val 1 5 10 Trp Gly Arg Cys Val Tyr Ala Gly Gly Leu Met Ala Glu Gln Asp Pro
I
25 Lys Glu Leu Ile Phe Ser Gly Ile Thr Ile Tyr Thr Asp Lys Asn Phe 40 Thr Arg Ala Lys Lys Tyr Phe Glu Lys Ala Cys Lys Ser Asn Asp Ala 55 Asp Gly Cys Ala Ile Leu Arg Glu Val Tyr Ser Ser Gly Lys Ala Ile 70 75 Ala Arg Glu Asn Ala Arg Glu Ser Ile Glu Lys Ala Leu Glu His Thr 90 Ala Thr Ala Lys Val Cys Lys Leu Asn Asp Ala Glu Lys Cys Lys Asp 100 105 110 Leu Ala Glu Phe Tyr Phe Asn Val Asn Asp Leu Lys Asn Ala Leu Glu 115 120 125 Tyr Tyr Ser Lys Ser Cys Lys Leu Asn Asn Val Glu Gly Cys Met Leu 130 135 140 Ser Ala Thr Phe Tyr Asn Asp Met Ile Lys Gly Leu Lys Lys Asp Lys 145 150 155 160 Lys Asp Leu Glu Tyr Tyr Ser Lys Ala Cys Glu Leu Asn Asn Gly Gly 165 170 175 Gly Cys Ser Lys Leu Gly Gly Asp Tyr Phe Phe Gly Glu Gly Val Thr 180 185 190 Lys Asp Phe Lys Lys Ala Phe Glu Tyr Ser Ala Lys Ala Cys Glu Leu 195 200 205 Asn Asp Ala Lys Gly Cys Tyr Ala Leu Ala Ala Phe Tyr Asn Glu Gly 210 215 220 Lys Gly Val Ala Lys Asp Glu Lys Gin Thr Thr Glu Asn Leu Glu Lys 225 230 235 240 Ser Cys Lys Leu Gly Leu Lys Glu Ala Cys Asp Ile Leu Lys Glu Gin 245 250 255 Lys Gin 4 oo INFORMATION FOR SEQ ID NO:667: SEQUENCE CHARACTERISTICS: LENGTH: 75 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein C 4 (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori 444* (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...75 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:667 Val Ala Leu Thr Leu Gly Ala Arg Gly Gly Val Tyr Leu Cys Gly Gly 1 5 10 Ile Ile Pro Arg Phe Ile Asp Tyr Phe Lys Thr Ser Pro Phe Arg Ala 25 Arg Phe Glu Thr Lys Gly Arg Met Gly Ala Phe Leu Ala Ser Ile Pro 40 Val His Val Val Met Lys Lys Thr Pro Gly Leu Asp Gly Ala Gly Ile 55 Ala Leu Glu Asn Tyr Leu Leu His Asp Arg Ile 70 INFORMATION FOR SEQ ID NO:668: SEQUENCE CHARACTERISTICS: LENGTH: 421 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION .421 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:668 Met Lys Gly Leu Thr Met Lys Lys Leu Val Phe Ser Met Leu Leu Cys Cys Lys Ser C Pro C Ser Asn Ile Asn Lys Tyr; Asn 145 Gly Ile Ser Asn Glu 225 Asn Val Lys Asp Glu 305 Lys Leu ;lu Ile s0 -In Ser kla ln Leu 130 Lys Glu Ser Gly Tyr 210 Gin Lys Leu Gin Pro 290 Gix Asp Let Thr I Lys 2 Leu Ser Gin Sen 115 Gin 4 Ile Gin Gly Arg 195 Glu Lys Gin Gin Gly 275 Ile iGlu Ala iThr Tal 00 Iis rg ;in 3er [yr 100 Ile ln Val Thr Ser 180 Ala Ser Arg Leu Thr 260 Ile Lys Ilf Gix Le Phe 2 Val Tyr Lys Ala Gin Glu.
Gln Asn Gin 165 Gly Trp Glu Arg Lys 245 Glu His Asn Gin i Sen 325 i Lys kla ;er ;lu Val 70 Ile Ile Asn Cys Leu 150 Thr Tyr Gly Gin Phe 230 Asp Phe Tyr Val Thi 310 Gir Ty Glu Gin Glu 55 Asn Thr Glu Trp Pro 135 Lys Ala Gly Glu Ala 215 Leu Lys -Gy Cys Phe 295 Leu Ala Leu Gly C Ala 40 Ile Asn 1 Leu Ser Asn 120 Trp Asp Arg Asn Met 200 Leu Leu Leu Val Thr 280 Arg Thr Tyr Lys ;lu Chr Ile 4et Ala Ile 105 Ala Leu Leu Asp Met 185 Leu Leu Arg Asp Thr 265 Glt Thi Lei Ai G1 10 Thr I Ile Ser I Ile Asn 90 Arg Gin Asn Asn Va1 170 Gin Cys Ala Val Pro 250 Asp I Asn Thr i Asp Asn 330 i Ile ?ro Ile ys ksn 75 Pro Tyr Asn Val Asn 155 din Sen Lys Thr Lys 235 Phe Pro Lys Arg Leu 315 Phe Thr Leu Gly Ala Thr Met Asn Leu Asn 140 Leu Asn Leu Met Gly 220 Lys Leu Thr Glu Leu 300 Ile Asr Asr Ile Val Lys Met Gin Ala Thr Asn Gin Val Tyr Glu 110 Leu Arg 125 Ala Leu Ile Thr Leu Ile Ala Gly 190 Val Asn 205 Asn Asn Lys Val Lys Arg Ala Asn 270 Thr Gly 285 Asp Asn Lys Ala Gln Arg Gin Met ksn Jal Gln Ser Leu Asn Asn Thr Lys Gin 175 Glu Asp Pro Asn Leu 255 His Lys Glu Ser Ile 335 Leu Asp Asp Val Leu Gln Leu Lys Asn Asn 160 Ser Leu Ser Glu Asp 240 Asp Asn Cys Leu Asn 320 Lys Phe 340 350 Leu Asn Gin Thr Met Ala Met Gin Ser Glu Ile Met Thr Asp Asp Tyr 557 355 360 365 Phe Arg Gin Asn Asn Asp Gly Phe Gly Glu Lys Glu Asn His Ile Asp 370 375 380 Glu Gin Leu Thr Gin Lys Arg Ile Asn Glu Arg Glu Arg Ala Arg lle 385 390 395 400 Tyr Phe Gln Asn Pro Asn Val Lys Phe Asp Gin Phe Gly Phe Pro le 405 410 415 Phe Ser Ile Trp Asp 420 INFORMATION FOR SEQ ID NO:669: SEQUENCE CHARACTERISTICS: LENGTH: 81 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...81 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:669 Met Ser Val Asn Leu Leu Glu Leu Leu Lys Leu Ala Val Pro Leu Ala 1 5 10 Val Ile Leu Ser Val Gin Val Ala Val Met Ile Leu Tyr Val Val Leu 20 25 Val Thr Phe Arg Val Cys Gly Lys Asp Tyr Asp Ala Ala Val Leu Cys 40 Ala Gly His Cys Gly Phe Gly Leu Gly Ala Thr Pro Thr Ala Met Val 50 55 Asn Met Gin Thr Ile Thr Asn His Tyr Gly Pro'Ser His Val Ala Phe 70 75 Ile S' INFORMATION FOR SEQ ID NO:670: SEQUENCE CHARACTERISTICS: LENGTH: 112 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...112 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:670 II I 558 Met Gin Leu Ser Pro Leu Gin Ser Ala Leu Leu Tyr Phe Arg Tyr Phe 1 5 10 Ile Tyr Pro Giu Lys Lys Thr Arg Ser Phe Asp Leu Ser Asp Leu Ile 25 Phe Ile Vai Met Val Phe Leu Val Leu Ala Leu Gly Leu Leu Met Ser 40 Giu Glu Ile Ser Ile Ser Tyr Asn Giu Ala Lys Asp Phe Phe Tyr Ser 55 Asp Ala Trp Phe Val Lys Ile Ala Gin Lys Ser Val Ala Ile Leu Arg 70 75 Pro Lys Arg Phe Giy Phe Lys Ile Ala Phe Phe Asp Arg Ser Arg His 90 Gin His Val Phe Ile Leu Pro His Arg Ala Lys Asp Phe Lys Lys Aia 100 105 110 INFORMATION FOR SEQ ID NO:671: SEQUENCE CHAR.ACTERISTICS: LENGTH: 325 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Heiicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .325 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:671 Leu Ala Gly Leu Unk Val Gly Cys Unk Arg Met Lys Gin Thr Phe Trp 1 5 10 *Unk Leu Ser Trp Gly Giu Lys Sen Gin Lys Val.Cys Val His Ang Pro 25 Trp TIyr Ala Ile Trp Ser Cys Asp Lys Trp Glu Giu Lys Thr Gin Gin 40 *Phe Thr Gly Asn Gin Leu Ile Thr Lys Thr Trp, Ala Gly Gly Asri Ala 55 *Ala Asn Tyr Tyr His Ser Gin Asn Asn Gin Asp Ile Thr Ala Asn Leu 70 75 Lys Asn Asp Asn Gly Thr Tyr Phe Leu Ser Gly Leu Tyr Asn Tyr Thr 90 *Gly Gly Glu Tyr Asn Gly Gly Asn Leu Asp Ile Giu Leu Gly Ser Asn 100 105 110 Ala Thr Phe Asn Leu Gly Ala Ser Ser Gly Asn Ser Phe Thr Ser Trp 115 120 125 *Tyr Pro Asn. Gly His Thr Asp Val Thn Phe Ser Ala Gly Thr Ile Asn 130 135 140 Val Asn Asn Ser Val Glu Val Gly Asn Arg Val Gly Sen Gly Ala Gly 145 150 155 160 Thr His Thr Giy Thr Ala Thr Leu Asn Leu Asn Ala Asn Lys Val Thr 165 170 175 Ile Asn Sen Asn Ile Sen Ala Tyr Lys Thr Ser Gin Val Asn Val Gly 180 185 190 Asn Ala Asn Ser Val Ile Thr Ilie Asn Ser Vai Sen Leu Asn Gly Glu 195 200 205 Thr Cys Unk Sen Leu Ala Arg Val Giy Val Gly Ala Asn. Cys Ser Thr 210 215 220 Ser Gly Pro Ser Tyn .Ser Phe Lys Gly Thr Thr Asn Ala Thr Asn Thr 225 Thr Phe Phe Lys Thr 305 Thr Ser 245 Lys Asn Ser Gin As n 325 230 Ser Gly Ser Phe Thr 250 Leu Asn Gly Gly Ala 265 Asn Thr Ala Phe Asn 280 Phe Asn Gly Ala Asn 295 Ala Thr Phe Gin Asn 310 235 Phe Phe Ser Phe Ser 315 Glu Glu Asn Ala 255 Thr Phe Asn Lys 270 Gly Ser Phe Thr 285 Ser Asn Ala Ser 300 Ser Phe Asn Gly INFORMATION FOR SEQ ID NO:671: SEQUENCE CHARACTERISTICS: LENGTH: 325 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 325 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:671
*Q
a a.
a a.
a a Leu Ala Gly Leu Unk Val Gly Cys Unk Arg Met Lys Gin Thr 1 Unk Trp Phe Ala Lys Gly Ala Tyr Val 145 Thr Ile Asn Thr Leu Tyr Thr Asn Asn Gly Thr Pro 130 Asn His Asn Ala Cys 210 Ser Ala Gly Tyr Asp Giu Phe 115 Asn Asn Thr Ser Asn 195 Unk Trp 20 Ile As n Tyr Asn Tyr 100 Asn Gly Ser Gly Asn 180 Sen Sen 5 Gly Trp Gin His Gly Asn Leu His Val1 Thr 165 Ile Val Leu Giu Sen Leu Sen 70 Thr Gly Gly Thr Giu 150 Ala Ser Ile Lys Cys Ile 55 Gin Tyr G ly Ala Asp 1-35 Val Thr Ala Thr Sen Asp 40 Thr Asn Phe Asn Ser 120 Vai Gly Leu Tyr Ile 200 Val Gln 25 Lys Lys Asn Leu Leu 105 Ser Thr Asn Asn Lys 185 Asn Gly 1.0 Lys Val Cys Val His Phe Tnp Arg Pro rrp Thr Gin Sen 90 Asp Gly Phe Ang Leu 170 Thr Ser Val Giu* Glu Trp Ala Asp Ile 7S Gly Leu Ile Giu Asn Ser Ser Ala 140 Val Gly 155 Asn Ala Ser Gin Val Ser Gly Ala Lys G ly Thr Tyr Leu Phe 125 Gly Ser Asn Val Leu 205 Asn Thr Gly Ala Asn Gly 110 Thr Thr Gly Lys Asn 190 As n Cys Gin Asn Asn Tyr S er Sen Ile Ala Val1 175 Val Gly Ser Gin Ala Leu Thr Asn Tnp Asn Gly 160 Thr dly Giu Thr Ala Ang 215 Ser Gly Pro Ser Tyr Sen Phe 225 230 Lys Gly Thr Thr 235 Asn Ala Thr Asn Thr 240 Thr Phe Phe Lys Thr 305 Thr Phe Ser As n Gly 290 Phe Phe Ser G ly Ala 275 Thr Asn Thr Unk Ala 260 Thr Ser As n Phe Ser 245 Lys Asn Ser Gin Asn 325 Ser Gly Ser Phe Thr P 250 Leu Asn Gly Gly Ala P 265 Asn Thr Ala Phe Asn S 280 Phe Asn Gly Ala Asn P1 295 Ala Thr Phe Gin Asn S( 310 3 560 ie Glu Glu Asn Ala Thr 255 le Thr Phe Asri Lys Lys 270 !r Gly Ser Phe Thr Phe 285 ie Ser Asn Ala Ser Tyr 300 r Ser Phe Asn Gly Gly IS 320 INFORMATION FOR SEQ ID NO:672: SEQUENCE CHARACTERISTICS: LENGTH: 271 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iJii) HYPOTHETICAL. YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .271 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:672 99.9 9* S 9 .9 S. 55 S9**
S
S S Leu Ala Asn Asp Thr Val Glu Gin Phe Leu 145 Gly Asn Leu Asp Gin 225 Leu Thr Asn Phe Ser Arg Thr Val Lys 130 Ile Val Val His Ala 210 Gly Ser Leu Val Lys Gly Lys Thr Met Leu Arg Ser Leu Ser Ile Asn Asn Pro G lu Gin 115 Leu Pro Asp Ile Ser 195 Ile Phe Gly 20 Ala Asp Thr Ser Asn 100 Leu Asp Gin G ly G iy 180 Met Val Leu Met Asn Leu Thr Ala Asn Pro Glu Ile Thr 165 Gin Gly Giy Glu Leu Val1 Phe Leu 70 Ile Leu Asp Gin Thr 150 Val Ile Asp Asn Leu 230 Aia Asn Tyr 55 Ser Thr Asp Gly G ly 135 Leu Ser Thr Asn Pro 215 Ser Gin Thr 40 Gin Pro Lys Ile Thr 120 Asn Pro Val Leu Leu 200 Asp Asn 10 Gin Th~ 25 Thr Gi' Ala Me Asp Gi' Met Ph 90 Ala Ii 105 Thr Al Leu Va Glu As Thr GI 17 Ala As 185 Phe Se Ser Gl r e e n 0 His Phe Gin Met 75 Ser Thr Tyr Thr Thr 155 Gly Phe Ile Gly Ile Lys T'yr G lu Gin Gly Thr Ser 140 Thr Leu Va 1 Thr Leu 220 Asp Lys Ala Val Gly Lys Arg 125 Glu Gin Gin Asn Asn 205 Gly Glu Thr Ser Gly Gly Se r Gly 110 Ser Gly Val Thr Pro 190 Ala Lys Giu Thr Arg Thr Leu Pro Phe G ly Tyr Asn Thr 175 Ala Ser Leu Met Ser Ala Asn Gly Lys Phe Asn Leu Ile 160 Ser Gly Gly Arg Thr 240 Tyr Ser Val Arg Leu Val 235 Asp Leu Ile Thr Ala. Gin Arg Ala Tyr Giu Ala Asn Ser Lys Ser Ile 245 250 255 Gin Thr Ala Asp Ala Met Leo Gin Thr Val Asn Ser Leu Lys Arg 260 265 270 INFORMATION FOR SEQ ID NO:672: SEQUENCE CHARACTERISTICS: LENGTH: 271 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein.
(iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1..-271 (xi) SEQUENCE DESCRIPTION: SEQ ID NO;672 eq
C.
*CCC
CC..
C.
C
Leu Ala Asn Asp Thr 65 Val Glu Gin Phe Leu 145 Gly As n Leu Asp Gin 225 Asp Leu Thr Asn Phe Ser Arg Thr Val Lys 130 Ile Val1 Val His Ala 210 Gly Leu Sen Ile As n Asn Pro Gbu Gin 115 Leu Pro Asp Ile Ser 195 Ile Phe Ile Sly Ala Asp Thn Sen Asn 100 Leu Asp Gin Gly Gly 180 Met Val Leu
S
Met Asn Leu Thn Ala Asn Pro Glu Ile Thr 165 Gin Gly Giy Glu Leo Val Phe Leo 70 Ile Leo Asp Gin Thn 150 Val Ile Asp Asn Leu Ala Asn Tyn 55 Ser Thr Asp Gly G ly 135 Leu Ser Thr Asn Pro 2715 Ser G-'n Thr 40 Gin Pro Lys Ile Thr 120 Asn Pro Val Leu Leu 200 Asp Asn Giln 25 Thr Ala Asp Met Ala 105 Thr Leu C lu Thr Aia 185 Phe Ser Val Thr Gly Met Gly Phe 90 Ile Ala Val1 Asp Gin 170 As n Ser Gin Arg His I Ie Phe Lys Gin Tyr Met Glu 75 Ser Gin Thn Gly TyrThr Thn Ser 140 Thr Thn 155 Gly Leu Phe Val Ile Thn Gly Leo 220 Leu Val 235 Ala Asn Asp Lys Ala Val1 Gly Lys Arg 125 Giu Gin Gin Asn Asn 205 Gly Giu Ser Thr Ser Gly Gly Sen Gly 110 Sen Gly Val1 Thr Pro 190 Ala Lys Glu Lys Thn Ang.
Thn Leo Pro Phe Gly Tyr Asn Thn 175 Ala Ser Leo Met Ser 255 Sen Ala Asn Gly Lys Phe Asn Leo Ile 160 Ser Giy C iy Arg Thr 240 Ile Ser Leo Val Lys Gly Lys Thr Met Leo Arg Ser Leo Tyr Ser Thr Aia Gin Arg Ala Tyr Glu 245 250 Gin Thr Ala Asp 260 Ala Met Leo Gin Thr 265 Val Asn Ser Leo Lys Arg 270 INFORMATION FOR SEQ ID NO:673: SEQUENCE CHARACTERISTICS: LENGTH: 78 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...78 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:673 Val Tyr Ala Leu Met Val Ala Phe Phe Ala Tyr Met Ser Tyr Cys Leu 1 5 10 Gly Tyr Gin Phe Ser Lys Phe Val Ser Lys Asn Asn Ile Ser Ser Leu 25 Ser Ser Leu Leu Ser Ser Cys Val Arg Val Val Ser Val Leu Ile Leu 40 Ser Leu Ser Ser Leu Glu Leu Arg Tyr Phe Ser Pro Leu Thr Ile Ile 55 Thr Met His Phe Ala Leu Thr Leu Ile Ile Leu Phe Phe Phe 70 INFORMATION FOR SEQ ID NO:674: SEQUENCE CHARACTERISTICS: LENGTH: 400 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein .(iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...400 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:674 Met Arg Ser Trp Met Lys Lys Lys Tyr Phe Thr Leu Leu Leu Gin Ser 1 5 10 Ser Val Val Leu Ala Val Phe Ile Gly Cys Ser Ser Thr Arg Asn His 25 Thr Phe Ser Ala Leu Ser Asn Gin Glu Asn Thr Asp Asp Lys Leu Pro 40 Val Val His Ser Ile Lys Thr Ile Asn Asp Val Ser Ser Val Gly Phe 55 Glu Trp Ser Lys Val Ala Asp Thr Tyr Asp Ile Asp Gly Phe Val Leu 70 75 Tyr Arg Leu Lys Lys Asp Ser Lys Leu Lys Arg Ile Ala Thr Ile Lys 90 Asn Pro Tyr Ala Thr His Tyr Tyr Asp Glu Gly Leu Glu Thr Glu Ser 100 105 110 Ser Tyr Thr Tyr Gin Leu Ala Thr Tyr Lys Gly Asp Lys Ile Ser Lys 115 120 125 Leu Ser Glu Pro Ile Leu Val Lys Thr Ser Phe Ile Asn Pro Val Glu
I
130 Ser Val Phe 145 Ser Pro His 135 Ala Ser Leu Glu 150 Pro Asn Pro Ser Tyr Pro Lys Val Ser LYS Asn Lys Asp Gly Lys Phe Leu Asfl Val C'o Gly Phe Val 225 Val Lys Asn
T
1 yr Val 305 Ala Gly Ser Lys Lys 385 Val Gin 210 Ile Arg Ser Arg Val 290 Ala Met Thr Pro mxr 370C Giu 195 Ile Val Val Pro Asn 275 Asp Val Gly Ile Lys 355 Pro 180 Phe Ile Giu Ser Glu 260 Asp Lys Asp Giu Gin 340 Ile .L a Phe ASP Ala Giu Gly Lys 230 Gin 245 G iu Lys Ile Lys Thr 325 Asp Ala As n Asp Tyr Giu Thr 310 Ser S er Thr Lys Asn I 21c, Thr Leu Val1 Lys Lys 295 His Asp Ser Tyr Gly 375 ~sp ~00 ~he .sys Thr Ile Phe 280 Asp Leu Arg Ala Ala 360 Leu Met Asp Arg Ala 265 Ile Asn Glu Pro Leu 345 Val 31y Leu Gin 250 Tyr Ala Leu Gly G iu 140 Ser Vai Lys Val 155 Tyr Ile Ile Gin Ala Val Lys Asn 190 Asp Gly Gin Lys 205 Asp Lys Ser Arg 220 Pro Lys Glu Ile 235 Ile Giu Leu Ser Arg Ile Tyr Ala 270 Gin Thr Thr Asn 285 Thr Arg Tyr Tyr 300 Ala Leu Pro Lys 315 Ala Pro Ile Ile The PArg 175 Arg Tyr Pro Ala Trp 255 Ser Thr Lys Giu Thr 335 Trp 160 Gin Leu Arg Ser Asn 240 Asp Asn Ser Va. I Pro 320 Lys Pro Ser Asp Val 400 330 Tyr Arg Trp Giu Asn 350 Phe Giu Ala 365 Asn Gin Phe 380 Asn ValI Leu Arg PhE Asn Ile Thr Gin Asp Met LYS Val Gly Val Ala Tyr Arg Tyr 390 395 Gln Val Val Ser a a a. a 9* a a.
a a INFORMATION FOR SEQ ID NO:675: SEQUENCE CHARACTERISTICS: LENGTH: 90 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/ KEYX: misc_feature LOCATION (xi) SEQUENCE DESCRIPTION: SEQ ID NO:675 Met Gin Asn Gly Tyr Tyr Ala Ala Thr Gly Ala Met Ala Thr Gin Phe 1 5 10 Asn Arg Leu Asp Leu Thr Ser Asn Asn Leu Ala Asn Leu Asn Thr Asn 25 Gly Phe Lys Axg Asp Asp Ala Ile Thr Gly Asp Phe Leu Arg Leu Tyr 40 Gin Giu Tyr Arg Giu Gin Leu Pro Leu Giu Asp Gin Thr Lys Ala Ser 55 Ala Lys Tyr Leu Asn Arg Unk Leu Asn Arg Val Pro Ile Leu Ser Unk 70 75 Ile Tyr Thr Unk Arg Unk Leu Gly Unk Val INFORMATION FOR SEQ ID NO:675: SEQUENCE CHARACTERISTICS: LENGTH: 90 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...90 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:675 Met Gin Asn Gly Tyr Tyr Ala Ala Thr Gly Ala Met Ala Thr Gin 1 5 10 Asn Arg Leu Asp Leu Thr Ser Asn Asn Leu Ala Asn Leu Asn Thr 25 Gly Phe Lys Arg Asp Asp Ala Ile Thr Gly Asp Phe Leu Arg Leu 40 Gin Glu Tyr Arg Glu Gin Leu Pro Leu Glu Asp Gin Thr Lys Ala 55 Ala Lys Tyr Leu Asn Arg Unk Leu Asn Arg Val Pro Ile Leu Ser 70 75 Ile Tyr Thr Unk Arg Unk Leu Gly Unk Val Phe Asn Tyr Ser Unk a a a. a INFORMATION FOR SEQ ID NO:676: SEQUENCE CHARACTERISTICS: LENGTH: 126 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...126 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:676 Met Leu Pro Thr Lys Thr Arg Ile Arg Asp Pro Asn Lys Gin Glu Leu 1 5 10 Thr Gin Pro Lys Ile Lys Gly Leu Ser Met Gly Lys Ile Leu Ala Ser 25 Leu Leu Gly Gly Gly Thr Asn Leu Phe Thr Gly Leu Ser Ser Asp Leu 40 Phe Ser Met Ile Leu Asn Phe Leu Phe Phe Leu Met Leu Met Met Gly 565 55 Leu Asn Glu Ala Leu Gly Lys Lys Phe Asn Leu Pro Met Asp Asn Ile 70 75 Lys Asn Phe Met Ala Glu Val Leu Lys Asn Gly Phe Asp Ser Ile Lys 90 Asn Met Gly Ser Ala Leu Val Gly Asn Gly Phe Gly Ser Ser Lys Ser 100 105 110 Asp Lys Thr Thr Asn Lys Met Ser Val Pro Gin Val Arg Leu 115 120 125 INFORMATION FOR SEQ ID NO:677: SEQUENCE CHARACTERISTICS: LENGTH: 195 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...195 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:677 Val Gly Ala Met Pro Thr Ile Gin Ile Arg Unk Phe Gly Ala Gly Gly 1 5 10 Ser Gly His Ser Asp Ala Thr Leu Met Leu Val Asn Gly Ile Pro Val S* 20 25 Met Ala Pro Tyr Ala His Ile Glu Leu Asp Ile Phe Pro Val Thr 35 40 Phe Gin Ala Ile Asp Arg Ile Asp Val Ile Lys Gly Gly Gly Ser Val 50 55 Gin Tyr Gly Pro Asn Thr Tyr Gly Gly Ile Val. Asn Ile Ile Thr Lys 70 75 Pro Ile Pro Asn Gin Trp Glu Asn Gin Ala Ala Glu Arg Unk Thr Tyr 90 o Trp Ala Lys Ala Arg Asn Ala Gly Phe Ala Ala Pro Unk Asp Lys Thr 100 105 110 Gly Asp Pro Ser Phe Ile Lys Ser Leu Gly Asn Asn Leu Leu Tyr Asn 115 120 125 Thr Tyr Val Arg Ser Gly Gly Met Ile Asn Lys His Val Gly Ile Gin 130 135 140 Arg Lys Leu Thr Gly Leu Glu Ala Lys Ala Leu Gly Thr Ile Ala Pro 145 150 155 160 Leu Val Phe Gin Thr Ile Gly Trp Met Gly Ser Met Thr Ser Met Lys 165 170 175 Ala Met Gly Leu Lys Pro Ile Thr Asn Thr Thr Ile Leu Ala Ile Unk 180 185 190 Gin Pro Gly 195 INFORMATION FOR SEQ ID NO:677: SEQUENCE CHARACTERISTICS: LENGTH: 195 amino acids TYPE: amino acid TOPOLOGY: linear 566 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...195 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:677 Val Gly Ala Met Pro Thr Ile Gin Ile Arg Unk Phe Gly Ala Gly Gly 1 5 10 Ser Gly His Ser Asp Ala Thr Leu Met Leu Val Asn Gly Ile Pro Val 25 Tyr Met Ala Pro Tyr Ala His Ile Glu Leu Asp Ile Phe Pro Val Thr 40 Phe Gln Ala Ile Asp Arg Ile Asp Val Ile Lys Gly Gly Gly Ser Val 55 Gin Tyr Gly Pro Asn Thr Tyr Gly Gly Ile Val Asn Ile Ile Thr Lys 70 75 Pro Ile Pro Asn Gin Trp Glu Asn Gin Ala Ala Glu Arg Unk Thr Tyr 90 Trp Ala Lys Ala Arg Asn Ala Gly Phe Ala Ala Pro Unk Asp Lys Thr 100 105 110 Gly Asp Pro Ser Phe Ile Lys Ser Leu Gly Asn Asn Leu Leu Tyr Asn 115 120 125 Thr Tyr Val Arg Ser Gly Gly Met Ile Asn Lys His Val Gly Ile Gin 130 135 140 Arg Lys Leu Thr Gly Leu Glu Ala Lys Ala Leu Gly Thr Ile Ala Pro 145 150 155 160 Leu Val Phe Gin Thr Ile Gly Trp Met Gly Ser Met Thr Ser Met Lys 165 170 175 Ala Met Gly Leu Lys Pro Ile Thr Asn Thr Thr Ile Leu Ala Ile Unk n P 180 185 190 Gin Pro Gly 195 INFORMATION FOR SEQ ID NO:678: SEQUENCE CHARACTERISTICS: S* LENGTH: 72 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...72 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:678 Met Ala Asn Met Met Met Ala Ala Ala Met Leu Gly Ile Asp Ser Cys 1 5 10 Pro Ile Glu Gly Tyr Asp Gin Glu Lys Val Glu Ala Tyr Leu Glu Glu 25 Lys Gly Tyr Leu Asn Thr Ala Glu Phe Gly Val Ser Val Met Ala Ser 40 Phe Gly Tyr Arg Asn Gin Glu Ile Thr Pro Lys Thr Arg Trp Lys Thr 55 Glu Val Ile Tyr Glu Val Ile Glu INFORMATION FOR SEQ ID NO:6 7 9: SEQUENCE CHARACTERISTICS: LENGTH: 111 amino.acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...111 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:679 Met Ala Gly Leu Val Leu Met Val Leu Leu Ala Ser Tyr Glu Ser Phe 1 5 10 Val Ser Lys Leu Asp Lys Val Asp Ala Ser Glu Ile Thr Trp Leu Lys 25 00 His Thr Asp Phe Asn Ala Leu Lys Leu Lys Val Ser Leu Ser Ile Val 35 40 Ala lie Ser Ala Ile Phe Leu Leu Lys Arg Tyr Met Ser Leu Glu Asp 50 55 Val Leu Ser Ser Ile Pro Lys Asp Thr Pro Leu Ser His Asn Pro Ile 65 70 75 Phe Trp Gln Val Val Ile His Leu Val Phe Val Cys Ser Ala Leu Leu 85 90 Thr Ala Val Thr Asn Asn Ile Ala Phe Ser Gin Lys Glu Arg His 100 105 110 INFORMATION FOR SEQ ID NO:680: SEQUENCE CHARACTERISTICS: LENGTH: 142 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: -protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...142 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:680 568 Met Ile Thr Ile Val Ile Ala Lys Ala Gly Asn Ile Val Lys Unk Asp 1 5 10 Ile Phe Thr His Ile Ser Asp Ile Lys Met Gly Leu Ile Lys Gly Gly 25 Gin Trp Gly Val Ile Gly Leu Gly Asn Ile Gly Lys Arg Val Ala Lys 40 Leu Ala Gin Ala Phe Gly Ala Lys Val Val Tyr Phe Ser Pro Lys Asp 55 Lys Lys Glu Glu Tyr Glu Arg Leu Ser Leu Glu Glu Leu Leu Lys Thr 70 75 Ser Gly Ile Ile Ser Ile His Ala Pro Leu Asn Glu Ser Thr Arg Asp 90 Leu lie Ala Leu Lys Glu Leu Gin Ser Leu Lys Asp Gly Ala Ile Leu 100 105 110 Ile Asn Val Gly Arg Gly Gly Ile Val Asn Glu Lys Unk Leu Ala Unk 115 120 125 Unk Leu Glu Thr Thr Asp Leu Tyr Tyr Ala Ser Asp Val Phe 130 135 140 INFORMATION FOR SEQ ID NO:681: SEQUENCE CHARACTERISTICS: LENGTH: 63 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...63 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:681 Val Asn Phe Asn Ala Lys Asn Ile Ser Ile Asp Asn Leu Val Glu Ile S1 5 10 "Asn Asn Arg Val Gly Ser Gly Ala Gly Arg Lys Ala Ser Ser Thr Val 25 Leu Thr Leu Gin Ala Ser Glu Gly Ile Thr Unk Ser Lys Asn Ala Glu 40 S.Ile Ser Leu Tyr Asp Gly Ala Thr Unk Ile Trp Leu Gin Thr Gly S: 50 55 INFORMATION FOR SEQ ID NO:682: SEQUENCE CHARACTERISTICS: LENGTH: 310 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION .310 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:682 Met 1 Met Ser Ile Lys Ile Gly Asp Val Lys 145 Asp Gin Cys Thr His 225 Gl) Gli.
Va Asi Ii Arg Thr Leu I Leu Leu Lys Ala Asn His Lys Lys Phe Lys Asn Leu Val Gly Pro Leu Cys Glu 100 Leu Glu Ile 115 Ser Vai Ser 130 Glu Val Ser Leu Ala Asn Thr Gly Phe 180 Gly Leu Leu 195 Ser Phe Ser 210 Glu Phe Ile Leu Leu Gln 1 Cys Giy Leu 260 1 Leu Val Tyr 275 le Leu Ser Leu Leu 3 ;lu 2ys Gln Glu Tyr Va1 Leu Ala Ser Phe 165 Tyr Gly Ala Asp Phe 245 Asp Gi Cys Va1 Glu Pro 70 Glu Va1 Glu Ala Leu 150 Ser Ala Ile Gl Gl.
23( Ph Lei Gin C Leu I Ile I 55 Tyr His Arg Gin Ser 135 Cys Ala Pro Ser Gly 215 Leu Arg e Ile u Lys ;lu I 3er I 10 .eu Leu I His Ile Thr 120 Asn Lys His His Lys 200 Va1 Pro Ser His Asp 280 .ys ila ;ly Lys Ser Pro 105 Leu Va1 Glu Ala Lys 185 Asp Iie Let Ale Lyl 26I Let Lys H 10 Leu I Gly Val Asp I Asn 90 Leu Lys Thr Tyr Asn 170 Leu Leu Lys 1 Arg x Leu 250 s Lys u Pro ,ys :ys .let 75 Slu Asn Lys Gly Arg 155 Pro Leu Ile Tyr Glu 235 Al Gli Ale Arg S Gly 2 Ile I Ala I Val Glu Thr Ile 140 Ala Lys Gly Asp Ala 220 Glu Tyr 1 Asn i Ile is Ala Ile Leu jer I ~la S ?ro Leu Ser His Pro 125 Leu Ile Asp Gly Thr 205 Asn Phe Gin Asn Asn 285 .eu 3er Ser Lys rrp ly 110 Asn Thr Leu Cys Va1 190 Gin Arg Gl Let Let 27 Il Met C Asn I Ser 2 Lys Arg Arg Leu Ser Pro Ala Glu 175 Gly Ile Thr Thr Arg 255 i Leu 0 e Tyr ly jeu kla hr Jai
BO
Glu Leu Leu Leu Leu 160 Tyr Gly Pro Arg Pro 240 Asp Arg Gly a Leu Thr Ala Ser Arg Val Gly Val Val Thr Phe Asn Ile Gly tly 290 e Ser 5 Pro Tyr Asp Leu 310 INFORMATION FOR SEQ ID NO:683: SEQUENCE CHARACTERISTICS: LENGTH: 169 amino acids TYPE: amino acid TOPOLOGY: Ifnear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...169 570 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:683 Val 1 Tyr Ile Thr Gin Leu His Gly Met Asp 145 Ala Ala Ser Lys Lys Gly Ile Tyr Cys Gly 130 Ala Cys Cys Lys Arg Ala Tyr Glu Tyr Thr 115 His Ile Thr Asn Thr Ala Ser Ala Leu Ala Leu Glu Glu Met Gin Lys Ile Gin Thr Leu Glu Phe 100 His Phe Val Phe Val Gly Val 25 Asp Lys Asn 40 Ser Asn Ala 55 Ser His Leu Leu Glu Gly Leu Glu Ile 105 Leu Ile Ala 120 Pro Thr Pro 135 Leu Gin Gin Val Glu Phe 10 Ile Ala Tyr Ala Glu Leu Gin Pro Lys Glu Pro Asp Thr 75 Leu Pro Lys Leu Tyr 155 Pro Ile Asn Ser Leu Glu Ile Leu 140 Ala Ser Leu Ala Leu Glu Val Glu 125 Ile Ile Val Leu Phe Thr Ile 110 Gly His Leu Leu Lys Val Cys Ile Tyr Ser Ala Gly Gin Pro Met Leu Phe Gly Asn 160 Leu Lys Asn INFORMATION FOR SEQ ID NO:684:
S.
S S *S S SEQUENCE CHARACTERISTICS: LENGTH: 84 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...84 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:684 Arg Unk Glu Lys Ile Met Thr Asn Phe Glu L 5 10 Arg Leu Lys Thr Asn Ala Val Leu Thr Thr T 25 Phe Ile Gly Leu Leu Val Asp Ala Ile Arg I 40 Gly Ile Ala Leu Phe Lys Leu Met Thr Phe G 55 6 Thr Ile Val Met Phe Val Val Ala Phe Val I 70 Pro Lys Phe Met 1 Asn Ala Leu Unk Tyr ys Unk Ile Ala yr Cys Ala Ile le Asn Ala Asn ln Ile Phe Pro 0 le Unk Unk Ser INFORMATION FOR SEQ ID NO:684: SEQUENCE CHARACTERISTICS: LENGTH: 84 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...84 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:684 Arg Unk Glu Lys Ile Met Thr Asn Phe Glu 5 10 Arg Leu Lys Thr Asn Ala Val Leu Thr Thr 25 Phe Ile Gly Leu Leu Val Asp Ala Ile Arg 40 SGly Ile Ala Leu Phe Lys Leu Met Thr Phe 55 Thr Ile Val Met Phe Val Val Ala Phe Val 70 Pro Lys Phe Met 1 Asn Ala Leu Unk Tyr Lys Unk Ile Ala Tyr Cys Ala Ile Ile Asn Ala Asn Gln Ile Phe Pro Ile Unk Unk Ser 9* a INFORMATION FOR SEQ ID NO:685: SEQUENCE CHARACTERISTICS: LENGTH: 76 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...76 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:685 Met Unk Met Ser His Ile Ile Lys Ser Ile Glu Ala Leu Asp Asp Tyr 1 5 10 Thr Ile Arg Phe Thr Leu Asn Gly Pro Glu Ala Pro Phe Leu Ala Asn 25 Leu Gly Met Asp Phe Leu Ser Ile Leu Ser Lys Asp Tyr Ala Asp Tyr 40 Leu Ala Gin Asn Asn Lys Lys Asp Glu Leu Ala Lys Unk Pro Val Gly 55 Thr Gly Pro Phe Lys Phe Phe Leu Trp Asn Lys Arg 70 INFORMATION FOR SEQ ID NO:685: SEQUENCE CHARACTERISTICS: LENGTH: 76 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...76 (xi) SEQUENCE DESCRIPTION: SEQ ID N0:685 t Unk Met Ser His Ile Ile Lys Ser Ile Glu 5 10 r Ile Arg Phe Thr Leu Asn Gly Pro Glu Ala 25 u Gly Met Asp Phe Leu Ser Ile Leu Ser Lys 40 u Ala Gin Asn Asn Lys Lys Asp Glu Leu Ala 55 r Gly Pro Phe Lys Phe Phe Leu Trp Asn Lys 70 Met 1 Th: Lei Lea Th: Ala Leu Asp Asp Tyr Pro Phe Leu Ala Asn Asp Tyr Ala Asp Tyr Lys Unk Pro Val Gly Arg a a a INFORMATION FOR SEQ ID NO:686: SEQUENCE CHARACTERISTICS: LENGTH: 196 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...196 (xi) SEQUENCE DESCRIPTION: SEQ ID N0:686 Leu Met Arg Lys Ile Phe Ser Tyr Ile Ser Lys Val Leu 1 5 10 Gly Val Val Tyr Ala Glu Pro Asp Ser Lys Val Glu Ala 25 Arg Lys Gin Glu Ser Ser Leu Asp Lys Lys Ile Arg Gin 40 Ser Lys Glu Leu Lys Asn Lys Glu Leu Lys Asn Lys Asp 55 Lys Glu Glu Lys Lys Glu Thr Lys Ala Lys Arg Lys Pro 70 75 Val His His Gly Asp Ala Lys Asn Pro Thr Pro Lys Ile 90 Lys Ile Lys Gly Ser Ser Lys Gly Val Gln Asn Gin Gly 100 105 Asn Ala Pro Lys Pro Glu Glu Lys Asp Thr Thr Pro Gin 115 120 125 Lys Asn Lys Glu Thr Ser Pro Ser Ser Gin Phe Asn Ser Leu Leu Glu Leu Arg Thr Val 110 Ala Ile Phe Glu Leu Lys Ala Pro Gin Thr Phe Ile Gly Lys Asn Glu Pro Asn Glu Gly Asn 145 Gly Gin Arg 130 Pro Ile Glu Leu 135 140 Asn Asn Ala Thr Asn Asn Thr Leu Glu Asp Lys Val Val Gly 150 155 160 Ser Leu Leu Val Asn Gly Ser Pro Ile Thr Leu Tyr Gin Ile 165 170 175 Glu Gin Glu Lys Ser Lys Val Ser Unk Ala Unk Ala Arg Asp 180 185 190 link link 195 INFOF14ATION FOR SEQ ID NO:686: SEQUENCE CHARACTERISTICS: LENGTH: 196 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .196 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:686 Leu Met Arg Lys Ile Phe Sen Tyr Ile Ser Lys Vai Leu Leu a.
a a a Phe Ile Giy Val Val Tyr Ala Glu Pro Asp Ser Lys Val Glu Ala Leu Giu Gly 25 Arg Ser Lys Val Lys Asn Lys Asn 145 Gly Gir Ar Lys Gin Giu Lys Giu Leu Glu Glu Lys His His Gly Ile Lys Gly 100 Ala Pro Lys 115 Asn Lys Giu 130 *Pro Asn Asn Sle Sen Leu Glu Giu Gin 180 Leu Unk link 195 Ser Ser Lys Asn L~ys Giu Asp Ala 85 Ser Sen pro Giu Thr Ser Ala Thr 150 Leu Val 165 Giu Lys Leu L~ys 55 Thr Lys Lys Giu Pro 135 Asn Asn Sen Asp 40 G iu Lys Asn Gly Lys 120 Sen Asn G ly Lys Lys Leu Ala Pro Val 105 Asp Sen Thr Sen Val1 185 Lys Lys Lys Thr 90 Gin Thr Gin Leu Pro 170 Sen Ile Asn Arg' 75 Pro Asn Thr Phe G iu 155 Ile Unk Lys Lys Lys Gin Pro Asn 140 Asp Thr Ala Asp Pro Ile Gly Gin 125 Sen Lys Leu Un Leu Arg Thr Val1 110 Ala Ile Vai Ala 190 Lys Ala Pro Gin Thr Phe Val Gin 175 Arg Asn Giu Pro Asn Glu Giy Gly 160 Ile Asp INFORMATION FOR SEQ ID NO:687: SEQUENCE CHARACTERISTICS: LENGTH: 142 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...142 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:687 Val Leu Trp Val Leu Tyr Phe Leu Thr Ser Leu Phe Ile Cys 1 Ile Lys Gly Met Leu Arg Pro Ile Val Ile Ile Pro Ser Leu Leu Ala 130 Leu Gin Phe Phe Gly Ile Val 115 Phe Lys His Phe Pro 70 Glu Ala Asp Ala Lys Ser His Ala 40 Ala Leu 55 Phe Val Asp Ile Val Gly Phe Ser 120 Ile Phe 135 Met Arg Ala Phe Asn Val 105 Pro Tyr 10 Leu Thr Cys Leu Leu Val Leu Ala Phe Pro Tyr Gly 75 Ser Cys Phe Gly Val Arg Leu Leu Leu Ile Ser Gly 140 Asp Ala Glu Ser Ser Ile Leu 125 Tyr Asn Gly Pro Leu Pro Ser 110 Pro Gin Ser Leu Ala Asn Gly Leu Phe Glu Val Phe Lys Ile Ser Thr Tyr Phe 9* INFORMATION FOR SEQ ID NO:688: SEQUENCE CHARACTERISTICS: LENGTH: 86 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...86 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:688 Met Ala Cys Lys Phe Cys Pro Lys Ile Arg Lys Thr Asp Trp Ile 1 5 10 Ile Leu Ile Ala Ala Leu Gly Phe Tyr Ser Val Asn Lys Leu Gly 25 Ala Pro Lys Phe Asn Thr Pro Thr Pro Lys Ser Ser Arg Pro Leu 40 Arg Pro Ile Glu Lys Pro Asn Asn Met Thr Glu Glu Glu Arg Lys 55 Arg Phe Ile Glu Leu Gin Lys Ala Cys Leu Leu His Lys Asp Lys 70 Ala Cys Glu Glu Val Phe INFORMATION FOR SEQ ID NO:689: SEQUENCE CHARACTERISTICS: LENGTH: 121 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...121 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:689 Val Asp Ser Ile Leu Ile Asp Glu Ala Arg Thr Pro Leu Ile Ile Ser 1 5 10 Gly Pro Val Asp Arg Arg Met Glu Asn Tyr Asn Lys Ala Asp Glu Val 25 Ala Lys Ser Met Gin Val Glu Val Asp Phe Thr Ile Asp Glu Lys Asn 35 40 Arg Ala Ile Leu Ile Thr Glu Glu Gly Ile Lys Lys Ala Glu Asn Leu 55 Phe Gly Val Asp Asn Leu Tyr Lys Ile Glu Asn Ala Ala Leu Ser His 65 70 75 His Leu Asp Gin Ala Leu Lys Ala Asn Tyr Leu Phe Phe Ile Asp Lys 85 90 Asp Tyr Ile Val Ala Asn Asn Glu Val Val Ile Val Asp Lys Phe Thr 100 105 110 Asp Arg Leu Asn Glu Gly Glu Ala Leu 115 120 INFORMATION FOR SEQ ID NO:690: S(i) SEQUENCE CHARACTERISTICS: LENGTH: 59 amino acids TYPE: amino acid TOPOLOGY: linear 90 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE:- ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...59 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:690 Met Thr Ile Thr Thr Leu Ser Phe Leu Phe Thr Thr Pro Glu Val Phe 1 5 10 Val Asn Gin Asp Phe Pro Trp Leu Ser Gly Ala Gly Arg Leu Val Val 25 576 Lys Asp Leu Ala Leu Phe Ala Gly Gly Leu Phe Val Ala Gly Phe Asp 40 Arg Asn Ala Ile Trp Arg Val Lys Gly Phe Ala INFORMATION FOR SEQ ID NO:691: SEQUENCE CHARACTERISTICS: LENGTH: 142 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...142 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:691 Val Phe Ser Gly Asn Lys Arg Ala Ile Asn Tyr Arg Thr Ile Val Ser 1 5 10 Ala Phe Val Ile Gin Val Ala Leu Gly Ala Leu Ala Leu Tyr Val Pro 20 25 S Leu Gly Arg Glu Ile Leu Gin Gly Leu Ala Ser Gly Ile Gin Ser Val 35 40 Ile Gly Tyr Gly Tyr Glu Gly Val Arg Phe Leu Phe Gly Asn Leu Ala 55 Pro Asn Ala Lys Gly Asp Gin Gly Ile Gly Gly Phe Ile Phe Ala Ile 70 75 S Asn Val Leu Ala Ile Ile Ile Phe Phe Ala Ser Leu Ile Ser Leu Leu 85 90 Tyr Tyr Leu Lys Ile Met Pro Leu Val Ile Asn Leu Ile Gly Gly Ala 100 105 110 Leu Gin Lys Cys Leu Gly Thr Ser Lys Ala Glu Ser Met Ser Ala Ala 115 120 125 Ala Asn Unk Unk Val Ala His Thr Glu Asp Unk Leu Ser His 130 135 140 INFORMATION FOR SEQ ID NO:692: SEQUENCE CHARACTERISTICS: LENGTH: 80 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...80 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:692 Met Gly Ile Val1 Gly Leu Leu Asp Gly Val Gly Ile Ser Asn Ala Ile Asn Ile 10 Ala Ser Gly Ile Cys Ala Ile Ala Leu 25 Unk Ser Ser Leu Ser Cys Leu Leu Ala 40 Gly Val Lys Unk Pro Phe Arg Lys Asp 55 Arg Ile Phe Trp Val Trp Unk Unk Unk 70 75 Ile Asp Gly Phe Asn Leu Val Ile His Tyr Tyr Met Val Leu Gly Phe Leu Gly Arg Ser Phe Leu Ser Cys Ile INFORMATION FOR SEQ ID NO:693: SEQUENCE CHARACTERISTICS: LENGTH: 179 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iiiJ) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 179 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:693 Met Lys Arg Ser Ser Val Phe Sen Phe Leu Val Ala a.
a a.
a a.
a 1 Val Ser Giu Pro 65 Asp Val Thr Arg Asp 145 Gin Leu Gly Thr Lys Ala Lys Gin Asp Thr 130 Met
LYS
Val Ser 20 Ala Giu Glu Glu Ala 100 Phe Ser Lys Arg 5 His Val1 Pro Sen Ile Lys Gly Val Thr Glu 165 Lys Gin Lys Gly 70 Lys Glu Sen Lys Ile 150 Met Thn Gin 55 Thn Giu Asn Ser Asn 135 Ser Asp Ala 40 Giu Ile Sen His Glu 120 Ala Phe Asn 25 Pro Pro Ile Asp Met 105 Leu Gly 10 Lys Val1 Ala Ala Gin 90 Gin Asn Val Glu Thn Val Thr Thr Pro Vai Sen Ile 75 Giu Thr Val Leu Gin Ala Ile Lys 140 Sen Lys Phe Leu Ala Gly Glu Pro Val Giu Tyr Phe Leu Asp Leu Glu 110 Leu Gly 125 Gly Val Pro Lys Leu Asp Ala Glu Asp Glu Gly Val Glu Cys Val1 Val Pro Lys Phe Ile Asn Lys Lys Val1 160 Cys Tyr Ang Glu Asn Arg Arg Val Asp Val Lys 170 175 INFORMATION FOR SEQ ID NO:693: SEQUENCE CHARACTERISTICS: LENGTH: 179 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...179 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:693 Met Lys Arg Ser Ser Val Phe Ser Phe Leu Val Ala Phe Leu Leu Val 1 5 10 Val Gly Cys Ser His Lys Met Asp Asn Lys Thr Val Ala Gly Asp Val 25 Ser Thr Lys Ala Val Gin Thr Ala Pro Val Thr Thr Glu Pro Ala Pro 40 Glu Lys Glu Glu Pro Lys Gln Glu Pro Ala Pro Val Val Glu Glu Lys 55 Pro Ala Ile Glu Ser Gly Thr Ile Ile Ala Ser Ile Tyr Phe Asp Phe 70 75 Asp Lys Tyr Glu Ile Lys Glu Ser Asp Gin Glu Thr Leu Asp Glu Ile 85 90 Val Gin Lys Ala Lys Glu Asn His Met Gin Val Leu Leu Glu Gly Asn 100 105 110 Thr Asp Glu Phe Gly Ser Ser Glu Tyr Asn Gin Ala Leu Gly Val Lys 115 120 125 Arg Thr Leu Ser Val Lys Asn Ala Leu Val Ile Lys Gly Val Glu Lys 130 135 140 Asp Met Ile Lys Thr Ile Ser Phe Gly Glu Ser Lys Pro Lys Cys Val 145 150 155 160 Gin Lys Thr Arg Glu Cys Tyr Arg Glu Asn Arg Arg Val Asp Val Lys 165 170 175 Leu Val Lys INFORMATION FOR SEQ ID NO:694: SEQUENCE CHARACTERISTICS: LENGTH: 75 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...75 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:694 Met Leu His Lys Lys Tyr Arg Pro Asn Val Ala Ala Ile Ile Met Ser 1 5 10 Pro Asp Tyr Pro Asn Thr Cys Glu Val Phe Ile Ala Glu Arg Ile Asp 25 Ile Glu Gly Ala Trp Gin Phe Pro Gin Gly Gly Ile Asp Glu Gly Glu 579 40 Thr Pro Leu Glu Ala Leu Tyr Arg Glu Leu Leu Glu Glu Ile Gly Thr 55 Asn Glu Ile Glu Ile Leu Ala Gin Tyr Pro Arg 70 INFORMATION FOR SEQ ID NO:695: SEQUENCE CHARACTERISTICS: LENGTH: 99 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...99 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:695 Val Met Leu Met Ala Ile Phe Thr Pro Tyr Ile Leu Ile Leu Lys Met 1 5 10 Met Lys Lys Ser Met Ser Leu Phe Ala Asn Met Gly Leu Glu Gin Ile 20 25 Phe Cys Asn Arg Asp Ile Lys Asp Leu Asn Asp Phe Val Phe Gly Ile 40 Glu Val Gly Leu Asp Ser Asn Ala Arg Lys Asn Arg Ser Arg Lys Ala 55 Met Glu Asn His Leu Ile Gly Leu Phe Val Gin Ala Gin Leu Asn Phe 65 70 75 S Lys Glu Gin Val Asp Ile Arg Glu Phe Glu Asp Leu Arg Gin Ala Phe 85 90 Gly Asn Asp INFORMATION FOR SEQ ID NO:696: SEQUENCE CHARACTERISTICS: LENGTH: 209 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...209 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:696 Met Ile Arg Leu Ala Ala Phe Phe Leu Ala Leu Ala Cys Ala Ile Thr 1 5 10 Pro Lys Ser Arg Leu Leu Leu Lys Asn Val Leu Leu Asn Pro Thr Arg 25 Ile Glu Ala Phe Glu Val Leu Lys Lys Met Gly Ala His Ile Glu Tyr 40 Val Ile Gin Ser Lys Asp Leu Glu Val Ile Gly Asp Ile Tyr Ile Glu 55 His Ala Pro Leu.Lys Ala Ile Ser Ile Asp Gin Asn Ile Ala Ser Leu 70 75 Ile Asp Glu Ile Pro Ala Leu Ser Ile Ala Met Leu Phe Ala Lys Gly 90 Lys Ser Met Val Arg Asn Ala Lys Asp Leu Arg Ala Lys Glu Ser Asp 100 105 110 Arg Ile Lys Ala Val Val Ser Asn Phe Lys Ala Leu Gly Ile Glu Cys 115 120 125 Glu Glu Phe Glu Asp Gly Phe Tyr Ile Glu Gly Leu Gly Asp Ala Ser 130 135 140 Gin Leu Lys Gin His Phe Ser Lys Ile Lys Pro Pro Ile Ile Lys Ser 145 150 155 160 Phe Asn Asp His Arg Ile Ala Met Ser Phe Ala Val Leu Thr Leu Ala 165 170 175 Leu Pro Leu Glu Ile Asp Asn Leu Glu Cys Ala Asn Ile Ser Phe Pro 180 185 190 Thr Phe Gin Leu Trp Leu Asn Leu Phe Lys Lys Arg Ser Leu Asn Gly 195 200 205 Asn INFORMATION FOR SEQ ID NO:697: e SEQUENCE CHARACTERISTICS: LENGTH: 75 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori
FEATURE:
NAME/KEY: miscfeature LOCATION 1...75 i* S (xi) SEQUENCE DESCRIPTION: SEQ ID NO:697 Val Gly Ser Leu Lys Phe Leu Asn Ala Met Gly Val Asp Leu Lys Val 1 5 10 Lys Glu Ser Ala Asn Ile Met Val Gly Phe Ala Lys Asn Lys Thr Leu 25 Cys Ala Leu Phe Ile Leu Glu Glu Arg Leu Lys Ala Asn Ala Lys Glu 40 Val Ile Gin Ala Leu Gin Asn Gin Gly Leu Glu Leu Glu Ile Leu Ser 55 Gly Asp Asn Glu Ser Ser Val Lys Glu Cys Ala 70 INFORMATION FOR SEQ ID NO:698: SEQUENCE CHARACTERISTICS: LENGTH: 121 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .121 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:698 Met Glu Ala Leu Asn Ala Leu Asn Ala Gln Ser Asp Glu Gin Ile Leu 1 5 10 Cys Giu Gly Tyr Phe Val Leu Leu Gin Ile Leu Glu Pro Met Ile Pro 25 His Thr Ala Trp Glu Leu Ser Glu Arg Leu Phe Lys Arg Glu Asn Phe 40 Lys Pro Ile Glu Val Asp Glu Ser Ala Leu Ile Glu Asp Phe Met Thr 55 Leu Gly Leu Thr Ile Asn Gly Lys Arg Arg Ala Giu Leu Lys Val Asn 70 75 Ile Asn Ala Ser Lys Glu Glu Ile Ile Ile Leu Ala Lys Lys Glu Leu 90 c Glu Lys Tyr Leu Glu Asn Ala Sen Val Lys Lys Glu Ile Tyr Val Pro 100 105 110 *Asn Lys Leu Val Asn Phe Val Thr Ala 115 120 INFORMdATION FOR SEQ ID NO:699: SEQUENCE CHARACTERISTICS: LENGTH: 102 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .102 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:699 Met Lys Glu Ser Ile Lys Tyr Leu Leu Giu Ser Val Gly Leu Val Leu 1 5 10 Leu Met Sen Val Asn Pro Gly Phe Gly Gly Gin Lys Phe Leu Asp Leu 25 Val Leu Glu Lys Cys Leu Lys Val Lys Glu Leu Ile Lys Ang Tyr Asn 40 Pro Ser Cys Leu Leu Glu Val Asp Gly Gly Val Asn Asp Lys Asn Ile 55 The Glu Leu Gin Gin Ala Gly Val Asp Val Val Val Ser Gly Sen Tyr 70 75 Ile Phe Glu Ser Lys Asp Unk Lys Leu Ala Ile Glu Gly Leu Gin Asn .90 Val Arg Gin Pro Leu Ala 100 INFORMATION FOR SEQ ID NO:700: SEQUENCE CHARACTERISTICS: LENGTH: 131 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...131 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:700 Val His Asp Gly Val Leu Gly Trp Val Gly Phe Thr Leu Ile Ala Ser 1 5 10 S Met Tyr His Met Thr Pro Arg Leu Phe Lys Arg Glu Ile Tyr Ser Gly 25 Arg Leu Val Asp Phe Gin Phe Trp Ile Met Thr Leu Gly Ile Val Leu o* 35 40 Tyr Phe Ser Ser Met Trp Ile Ala Gly Ile Thr Gln Gly Met Met Trp 50 55 Arg Asp Val Asp Gin Tyr Gly Asn Leu Thr Tyr Gin Phe Ile Asp Thr S 65 70 75 Val Lys Ala Leu Ile Pro Tyr Tyr Asn Ile Arg Gly Val Gly Gly Leu 90 Met Tyr Phe Ile Gly Phe Ile Ile Phe Ala Tyr Asn Ile Phe Met Thr 100 105 110 Ile Thr Ala Gly Lys Lys Leu Glu Arg Glu Pro Asn Tyr Ala Thr Pro 115 120 125 Met Ala Lys 130 INFORMATION FOR SEQ ID NO:701: SEQUENCE CHARACTERISTICS: LENGTH: 441 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...441 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:701 Met Ile Thr Leu Phe Ser Phe Gly Ala Phe Ala Tyr Tyr Phe Val Ser Ser Thr Asp Glu Arg Asn Ile Trp
S.
a Ile Ser Leu Arg 145 Val Glu Val Lys Arg 225 Ala Lys Ile Ile Ile 305 Phe Glu Ser Leu Ile 385 Glu Lys Gin Leu Val Ile 130 Glu Ser Phe Leu Gly 210 Phe Arg Phe Asp Ile 290 Asp Ile Asp Gin Glu 370 Cys Ala Gly Lys Leu Ser 115 Leu Leu Cys Asp Phe 195 Lys Ser Ile Leu Glu 275 Glu Asn Gly Phe Ala 355 Ala Phe Asp Met Glu 435 Lys 100 Tyr Phe Arg Lys Asn 180 Leu Ile Ser Glu Met 260 Asp Ala Ala Asn Glu 340 His Met Thr Asn Lys 420 Arg His Ile Tyr Lys Tyr Lys Arg Leu Ser Ser 165 Cys Arg Leu Ile Gin 245 Ser Lys Asp Ile Asn 325 Lys Gly Gly Ile SGlu 405 Gly Thr Glu Asn Leu Val Ala Asp Asn Phe Gin 150 Lys Ile Ser Ser Phe 230 Leu Asp Lys Phe Lys 310 Leu Tyr SPhe SLeu SHis 390 SGlu SThr SCys Asn Glu Tyr Leu Glu Glu Tyr Leu 135 Val Gin Gin Ile Ser 215 Asp Ala Leu Ser Glu 295 Tyr Val Leu Gly Asn 375 Asp Leu Glu Ser Tyr Ile Lys Ala Val His Phe 120 Phe Lys Lys Lys Met 200 Met His Ser Ile Pro 280 Leu Ser Val Gin Leu 360 Leu Cys Pro Lys Asn 440 Gin Asn 25 Leu Asn Ile Gly Lys Arg Phe Lys 90 Phe Val 105 Leu Ala Val Leu Arg Phe Asp Glu 170 Ile Asn 185 His Glu Leu Lys Leu Asn Lys Asn 250 Asp Lys 265 Ile His Phe Ala Asp Asp Ser Asn 330 Pro Tyr 345 Gly Met Ser Tyr Val Phe SPro Pro 410 Ala Asn 425 Asp Glu Asn Phe Arg 75 Phe Leu Ile Gin Ala 155 Ile Ala Leu Glu Met 235 Tyr Ile Val Ile Lys 315 Lys Phe Tyr His Asn 395 Glu Met Tyr Arg His Ser Tyr Thr Ser 140 Gin Gly Met Arg Glu 220 Leu Gly Glu Ser Ala 300 Gin .Ser Lys Ile Tyr 380 Ser SAsn Arg Ser Glu Gin Asp Lys Val 125 Leu Gly Asp Asn Thr 205 Leu Ile Ser Lys Ser 285 Leu Val Lys Ser Ile 365 Ser Phe Leu His Asp rhr Leu Met Asp 110 Gly Leu Asp Leu Glu 190 Pro Ser Glu Asn Met 270 Ser Lys Phe Pro Ser 350 Lys Asn Tyr Arg Tyr Tyr Thr His Val Leu Leu Pro Lys Ala 175 Ser Ile Cys Gin Lys 255 Leu Asn Asn Leu Leu 335 Asn Asn Gly Asp Glu 415 Gin Arg Ile His Phe His Leu Leu Ser 160 Asn Arg Thr Lys Phe 240 Glu Leu Tyr Met Asp 320 Lys Pro Ala Arg Leu 400 Val Cys Gly Val Lys Glu Lys 430 INFORMATION FOR SEQ ID NO:702: SEQUENCE CHARACTERISTICS: LENGTH: 127 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (i1ii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE:I NAME/KEY: misc_feature LOCATION .127 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:702 Val Leu Leu Leu Ser Arg Met Gly Ile Ala Phe Ala His Ser Ile Phe 1 5 10 Trp Ser Ile Thr Ala Ser Leu Val Ile Arg Val Ala Pro Arg Asn Lys 25 Lys Gin Gin Ala Leu Gly Leu Leu Ala Leu dly Sen Sen Leu Ala Met 40 Ile Leu Gly Leu Pro Leu Gly Arg Ile Ile Gly Gin Ile Leu Asp Trp 55 Arg Ser Thr Phe Gly Val Ile Gly Gly Val Ala Thn Leu Ile Met Leu 70 75 Leu Met Trp Lys Leu Leu Pro His Leu Pro Ser Ang Asn Ala Gly Thr 90 Leu Ala Ser Val Pro Ilie Leu Met Lys Arg Pro Leu Leu Val Gly Ile 9..100 105 110 Tyr Leu His Vai Asn His Gly Tyr Phe Trp Ala Phe His His Leu .115 120 125 :9 INFORMATION FOR SEQ ID NO:703: a SEQUENCE CHARACTERISTICS: LENGTH: 286 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL- YES (vi) ORIGINAL SOURCE: 9 ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature too LOCATION .286 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:703 Met Gly Thr Leu Ile Giu Lys Trp Phe Gly Phe Ser Gin Ile Arg Glu 1 5 10 Giu Leu Glu Ala Arg Ile Ser Glu Leu Glu Asp Glu Asn Thr Glu Leu 25 Leu Arg Glu Arg Glu Tyr Leu Ala Ala Glu Thr Ser Glu Leu Lys Asp 40 Ala Asn Asp Gin Leu Arg Gin Lys Asn Asp Lys Leu Phe Ile Thr Lys 55 Asp Lys Leu Thr Lys Giu Asn Thr Glu Leu Phe Ala Giu Asn Giu Sen 70 75 Leu Ser Val Lys Ile Ser Gly Leu Giu His Ser Asn Asp Gin Leu Trp 90 Gin Asn Asn Asn Lys Leu Thr Lys Glu Lys Ala Glu Leu Lys Thr Glu 100 105 110 Lys Asp Ile Leu Ala-Lys Giu Asn Thr Arg Leu Leu Ala Ala Ang Asp 0 115 120 125 Arg Leu Thr Giu Glii Lys Arg Giu Leu Thr Thr Giu Lys Giu Arg Leu 130 135 140 Lys Arg Giu Asn Thr Glu Leu Thr His Lys Ile Thr Giu Leu Thr Lys 145 150 155 160 Giu Asn Lys Ala Leu Thr Thr Giu Asn Asp Lys Leu Asn His Gin Vai 165 170 175 Thr Ala Leu Thr Asn Giu Arg Asp Ser Leu Glu Gin Giu Arg Ala Arg 180 185 190 Leu Gin Asp Ala His Gly Phe Leu Giu Lys Arg Cys Thr Asn Leu Giu 195 200 205 Lys Glu Asn Gin Arg Leu Thr Asp Lys Leu Lys Gin Leu Giu Ser Ala 210 215 220 Gin Lys Ser Leu Giu Asn Thr Asn'Asn Gin Leu Arg Gin Ala Leu Giu 225 230 235 240 Asn Ser Asn Val Gin Leu Ala Gin Aia Lys Giu Unk Ile Ala Ile Giu 245 250 255 Unk Ser Giu Leu Unk Arg Arg Asn Arg Thr Leu Giu Giu Leu Arg Gly 260 265 270 Tyr Gly Ser Gin Lys Unk Ile Trp Thr Tyr Thr Unk Gly Vai 275 280 285 INFORMATION FOR SEQ ID NO:703: SEQUENCE CHARACTERISTICS: '0000,(A) LENGTH: 286 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE- TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature 'S LOCATION .286 Met(xi) SEQUENCE DESCRIPTION: SEQ ID NO:703 MtGly Thr Leu Ile Glu Lys Trp, Phe Gly Phe Ser Gin Ile Arg Giu 1 5 10 1s Glu Leu Glu Ala Arg Ile Sen Glu Leu Giu Asp Giu Asn Thr Glu Leu Le rgGu20 25 Le Ag l Arg Giu Tyr Leu Ala Ala Giu Thr Ser Giu Leu Lys Asp 40 Ala Asn A-sp Gin Leu Arg Gin Lys Asn Asp Lys Leu Phe Ile Thr Lys 55 Asp Lys Leu Thr Lys Giu Asn Thn Giu Leu Phe Ala Glu Asn Glu Ser 70 75 Leu Sen Val Lys Ile Ser Gly Leu Giu His Sen Asn Asp Gin Leu Trp 90 Gin Asn Asn Asn Lys Leu Thn Lys Giu Lys Ala Giu Leu Lys Thr Giu 100 105 110 Lys Asp Ile Leu Ala Lys Giu Asn Thr Arg Leu Leu Ala Ala Arg Asp 115 120 125 Arg Leu Thr Glu Glu Lys Arg Giu Leu Thn Thr Giu Lys Giu Arg Leu 130 135 140 Lys Arg Glu Asn Thn Glu Leu Thr His Lys Ile Thr Giu Leu Thr Lys 145 iso 155 160 Glu Asn Lys Ala Leu Thn Thr Giu Asn Asp Lys Leu Asn His Gin Val 165 170 175 Thr Ala Leu Thr Asn Glu Arg Asp Ser Leu Glu Gin Glu Arg Ala Arg 180 185 190 Leu Gin Asp Ala His Gly Phe Leu Glu Lys Arg Cys Thr Asn Leu Glu 195 200 205 Lys Glu Asn Gin Arg Leu Thr Asp Lys Leu Lys Gin Leu Glu Ser Ala 210 215 220 Gin Lys Ser Leu Glu Asn Thr Asn Asn Gin Leu Arg Gin Ala Leu Glu 225 230 235 240 Asn Ser Asn Val Gin Leu Ala Gin Ala Lys Glu Unk Ile Ala Ile Glu 245 250 255 Unk Ser Glu Leu Unk Arg Arg Asn Arg Thr Leu Glu Glu Leu Arg Gly 260 265 270 Tyr Gly Ser Gin Lys Unk Ile Trp Thr Tyr Thr Unk Gly Val 275 280 285 INFORMATION FOR SEQ ID NO:704: SEQUENCE CHARACTERISTICS: LENGTH: 110 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: prctein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...110 (xi) SEQUENCE .DESCRIPTION: SEQ ID NO:704 Val Leu Arg Lys Leu Leu Gly Lys Asn Cys Ile Glu Thr His Lys Gly 1 5 10 Val Gly Tyr Arg Leu Thr His Tyr Glu Lys Lys Ser Leu Lys Leu Phe S* 20 25 Leu Gly Thr Tyr Leu Gly Ser Ser Phe Val Leu Met Leu Val Ile Ser 40 S"Val Leu Ala Phe Asn Tyr Glu Lys Asn Glu Lys Ile Lys Unk Ile Arg 50 55 Met Asp Met Asp Lys Met Ala Ser Lys Ile Ala Ser Glu Ile Ile Gln 70 75 Leu His Met Gin Thr His Ala Asp Tyr His Asn Ala Leu Asn Ala Leu 85 90 Ile Ser Arg Tyr Lys Asp Val Ser Ile Unk Leu Unk Asp Thr 100 105 110 INFORMATION FOR SEQ ID NO:704: SEQUENCE CHARACTERISTICS: LENGTH: 110 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori
I
(ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...110 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:704 Val Leu Arg Lys Leu Leu Gly Lys Asn Cys Ile GLu Thr His Lys Gly 1 5 10 Val Gly Tyr Arg Leu Thr His Tyr Glu Lys Lys Ser Leu Lys Leu Phe 25 Leu Gly Thr Tyr Leu Gly Ser Ser Phe Val Leu Met Leu Val Ile Ser 40 Val Leu Ala Phe Asn Tyr Glu Lys Asn Glu Lys Ile Lys Unk Ile Arg 55 Met Asp Met Asp Lys Met Ala Ser Lys Ile Ala Ser Glu Ile Ile Gin 70 75 Leu His Met Gin Thr His Ala Asp Tyr His Asn Ala Leu Asn Ala Leu 90 Ile Ser Arg Tyr Lys Asp Val Ser Ile Unk Leu Unk Asp Thr 100 105 110 INFORMATION FOR SEQ ID NO:705: SEQUENCE CHARACTERISTICS: LENGTH: 115 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES S: (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori
FEATURE:
NAME/KEY: misc_feature LOCATION 1...115 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:705 Met Arg Ile Ile Ile Arg Leu Leu Ser Phe Lys Met Asn Ala Phe Leu 1 5 10 Lys Leu Ala Leu Ala Ser Leu Met Gly Gly Leu Trp Tyr Ala Phe Asn 25 Gly Glu Gly Ser Glu Ile Val Ala Ile Gly Ile Phe Val Leu Ile Leu 40 Phe Val Phe Phe Ile Arg Pro Val Ser Phe Gin Asp Pro Glu Lys Arg 55 Glu Glu Tyr Ile Glu Arg Leu Lys Lys Asn His Glu Arg Lys Met Ile 70 75 Leu Gin Asp Lys Gin Lys Glu Glu Gin Met Arg Leu Tyr Gin Ala Lys 90 Lys Glu Arg Glu Ser Arg Gin Lys Gin Asp Leu Lys Glu Gin Met Lys 100 105 110 Lys Tyr Ser 115 INFORMATION FOR SEQ ID NO:706: SEQUENCE CHARACTERISTICS: LENGTH: 86 amino acids
I
TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...86 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:706 Val Arg Ser Cys Lys Gin Ile Phe Asp Lys Gly Leu Lys Pro Tyr Tyr 1 5 10 Lys His Ser Val Cys Leu Lys Pro Phe Phe Arg Phe Cys Phe Leu Lys 25 Ile His Ala Tyr Gin Gin Arg Tyr Arg Ala Phe Ala Leu Thr Leu Phe 40 Ser Cys Lys Phe Phe Asn Ala Cys Lys Ile Phe Ile Pro Ile Ile Asp 55 Phe Lys Ile Val Phe Ile Pro Ile Leu Lys His Gin Ala Lys Leu Lys 70 75 S Arg Val Ser Asn Ala Tyr INFORMATION FOR SEQ ID NO:707: SEQUENCE CHARACTERISTICS: LENGTH: 44 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein S(iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix)
FEATURE:
NAME/KEY: misc_feature LOCATION 1...44 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:707 Met Cys Gly Met Gly Phe Ile Gly Phe Lys Thr Lys Leu Thr Gin Thr 1 5 10 Lys Ala Phe Ile Ile Leu Ile Pro Ile Phe Gin Asp Arg Ala Val Lys 25 Ala Ala Thr Arg Ser Ala Pro Ile Gin Leu Ile Cys INFORMATION FOR SEQ ID NO:708: SEQUENCE CHARACTERISTICS: LENGTH: 560 amino acids TYPE: amino acid TOPOLOGY: linear 589 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION .560 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:708 Met GiV Asn Phe Asn Ser Tyr Gly Asp Leu Val Phe Asn Leu Ser His
S
S
S
1 5 Ser Val Ser His 1 Ala Asn Asn Asn I Gly Thr Tyr Thr I Asn Asn Gin Ile Tyr Ala Leu Ile Gly Leu Thr Tyr 100 Val Val Giy Phe 115 Leu Tyr Asn Lys 130 Pro Gin Ala Pro 145 Gin Ser Val Asp Trp Leu Asn Lys 180 Tyr Tyr Leu Glu 195 Asp Ile Ala Asn 210 Asp Ala Thr Asn 225 Arg Leu Ala Lys Leu Glu Arg Leu 260 Pro Asn Ala Met 275 Lys Asn Asn Val 290 Gly Gly Thr Unk 305 Ile Lys Gly Val Phe His Ala Asn 340 Val Tyr Ser Arg 355 Asn Giu Thr Trp 370 Leu Leu Ser Ile 385 la ?ro eu Thr Asp Asn Lys Val Thr Ser 165 Ile Ser Thr Ile Leu 245 Glu Asp Trp Thr Ile 325 Ile Ala Gl I ic Ile I Leu Ile 2 Gly 70 Ile Gly Asp Lys Leu 150 Ile Phe His Leu Leu 230 Ser Ala Val Ala Leu 310 Val Thr Phe Tyr Ele Ile ksp ;ly Asn GIn Ser Ile 135 Lys Unk Glu Ser Glu 215 Gin Asp Leu Ile Thr 295 Tyx G1 G1r I i As 37 Asn 9J Gin 40 Ser 2 Ser Gly Ala 1 Gin 120 Ala Gin Gin Thr Thr 200 Val Ile Thr Lys Leu 280 Gly Gly r Gly i Sen Lys 360 Lys hr ?he kla Ser Lys Val 105 Asn Val Tyr Ala Lys 185 Lys Ile Asn Ser Asn 265 Lys Val Ilf Ty] GlI 34! Ar Th
TY:
10 Gin G Asn A Lys A Leu A 7 His 1I 90 Sen X Gin 'J Ser 2 Ile Gly 170 Gly Asp Ala.
Thr Thr 250 Lys STyr Gly Asn Ala 330 Ser g Ser r Phe r Arg p Phe 410 ly la la '5 let Pal 'yr ksn kla 155 ly Ser Leu Asn Tyr 235 Phe Arg Ser Gl Unk 31S Ala Se2 01' 114 Ty 39 Thr Ser Ile Asn Vai Lys Ile Asp 140 Gin Asn Pro Thr .Pro 220 Thr Ala Phe Gin Ala 300 Gl ~Tyl Asr i Let As 38 r As 5 Ala T 3 Ser L Tyr I Tyr L Met I Asp C 2 Tyr '9 125 Pro I Ile C Gin 2: Leu Thr 205 Asn Gin Arg Ala Arg 285 Ser STyr Gly Vai i Thr 365 i Ser 0 p Thr hr 0 ,ys 'yr .eu 'hr ;ly 'hr le 1n kla ?he Ile Phe GIn Ser Asp 270 Asn Phe Asp Tyi Ast Me Trj Ile b Glu t Gly Lys I Asp Gly Ser Asn Gly' Ile 175 Ala Ala Lys Met Asp 255 Ala Arg Ile Arg Ser 335 i Val t Ser c Asp 3 Thr let Pal E'yr .eu ksn Leu Ile Asn Val 160 Asn Pro Gly Asn Ser 240 Phe Ile Vai Ser Phe 320 Gly Gly Leu Pro Thr 400 Asn Gin Sen 390 Asp Ala Lys Ile Asn Tyr Giy Tyr As 405 Met Phe Lys Asp Lys Sen 415 590 Tyr Tyr Val Ile Phe Ser Ala Leu 465 Ala Val Tyr Lys Tyr 545 Leu 435 Ala Ser Val1 Phe Thr 515 Phe Asp Lys 420 Arg Asp Arg Gly Ile 500 Phe Tyr Ile 425 Gdy Pro His Arg 485 Gly Ala Val1 Asn Ile Asn Tyr 470 Asp As n Ser Asn Ile 550 Met Lys 455 Phe Leu Asn Ile Ala 535 Thr Asp 440 Lys Asn Phe Thr Ile 520 Giy Gly Asp Ser Lys Ile Leu 505 Thr Ile As n Pro Val1 Asn As n 490 Ser Gly Gly Ile Ile Leu Ser 475 Ser Tyr Gly Ala G ly Pro Gin Vai Gly Leu Ser Tyr Ile Gly Leu 430 Tyr Thr 460 Tyr Met Arg Giu Arg 540 Met Asn 445 Ile Tyr Gly Asp Ile 525 Phe Unk Gin Asn Phe Asp Gly 510 Arg Gly Unk Phe Phe Vali Lys 495 Gly Leu Leu Unk INFORMATION FOR SEQ ID NO:709: SEQUENCE CHARACTERISTICS: LENGTH: 124 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .124 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:709 Leu Met Thr Lys Ser Leu Lys Leu Ile Gin Lys Gly Val Lys Asn Leu
S.
1 Tyr Val Val Asp Gly Phe Asp O lu Gly Leu Leu Asn Leu Arg Thr Arg 35 Ala Thr Phe Gly Tyr 115 Leu Sen Leu Met Ala Leu 100 Ala Lys Asn His Gly Phe Ala Glu Phe 70 His Ala Lys Thn Gly Leu Arg Val Asp 55 Ile Pro Ala His Ala Phe 40 Glu Unk Leu Asn Ala 120 Leu 25 Gly Ile Val Giu Ile 105 Ile Giu Giu
LYS
Gly Leu Ser Trp His Pro Arg Ala Giu Asn Leu Gin Ile His Ile Glu Gin Phe Asp Thr Leu Ser Leu Val1 Thr Phe Lys Giy Ala Ile 110 INFORMATION FOR SEQ ID NO:709: SEQUENCE CHARACTERISTICS: LENGTH: 124 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...124 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:709 Leu Met Thr Lys Ser Leu Lys Leu Ile Gin Lys Gly Val Lys Asn Leu 1 5 10 Tyr Glu Thr Leu Lys Asn Arg Ala Leu Glu His Gin Asp Thr Leu Met 25 Val Gly Arg Ser His Gly Val Phe Gly Glu Pro Ile Thr Phe Gly Leu 40 Val Leu Ala Leu Phe Ala Asp Glu Ile Lys Arg His Leu Lys Ala Leu 55 Asp Leu Thr Met Glu Phe Ile Unk Val Gly Ala Ile Ser Gly Ala Met 70 75 Gly Asn Phe Ala His Ala Pro Leu Glu Leu Glu Glu Leu Ala Cys Gly 90 Phe Leu Gly Leu Lys Thr Ala Asn Ile Ser Asn Gin Val Ile Gin Arg 100 105 110 Asp Arg Tyr Ala Gly Leu His Ala Ile Trp Leu Phe 115 120 INFORMATION FOR SEQ ID NO:710: SEQUENCE CHARACTERISTICS: S* LENGTH: 95 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...95 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:710 Leu Ser Asp Ala Ser Lys Arg Ser Leu Asn Pro Thr Leu Met Met Asn 1 5 10 Asn Asn Asn Thr Leu Pro Lys Pro Leu Glu Glu Ser Leu Asp Leu Lys 25 Glu Phe Ile Ala Leu Phe Lys Thr Phe Phe Ala Lys Glu Arg Gly Ser 40 Ile Ala Leu Glu Asn Asp Leu Lys Gin Ala Phe Thr Tyr Leu Asn Glu 55 Val Asp Ala Ile Gly Leu Pro Ala Pro Unk Lys Arg Glu Arg Lys Arg 70 75 Ser Tyr Cys Cys Gin Thr His Gin Ile Arg Asp Ala Pro Phe Arg 90 INFORMATION FOR SEQ ID NO:710: SEQUENCE CHARACTERISTICS: LENGTH: 95 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori Leu 1 Asn Glu Ile Val Ser (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...95 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:710 Ser Asp Ala Ser Lys Arg Ser Leu Asn Pro Thr 5 Asn Asn Thr Leu Pro Lys Pro Leu Glu Glu Ser Phe Ile Ala Leu Phe Lys Thr Phe Phe Ala Lys 40 Ala Leu Glu Asn Asp Leu Lys Gin Ala Phe Thr 55 Asp Ala Ile Gly Leu Pro Ala Pro Unk Lys Arg 70 75 Tyr Cys Cys Gin Thr His Gin Ile Arg Asp Ala Leu Leu Glu Tyr Glu Pro *5
S
INFORMATION FOR SEQ ID NO:711: SEQUENCE CHARACTERISTICS: LENGTH: 80 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...80 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:711 Leu Pro Ile Ile Leu Unk Val Ile Val Met Met 1 5 10 Val Gly Asp Phe Ile Glu Lys His Tyr Arg Val 25 Val Phe Leu Leu Val Val Gly Val Phe Leu Phe 40 Leu His Ile Asn Lys Asn Tyr Leu Tyr Ala Gly 55 Leu Ile Glu Cys Leu Unk Ile Phe Ile Glu Lys 70 75 Asn Lys Ser Glu Arg Ile Phe His Leu Ser Phe Phe Ser Lys Lys Thr Leu Ala Leu Glu Gly Leu Ile Gly Phe Ala Lys Met Lys Lys 9 9 9
S
S
INFORMATION FOR SEQ ID NO:711: SEQUENCE CHARACTERISTICS: LENGTH: 80 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...80 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:711 Leu Pro Ile Ile Leu Unk Val Ile Val Met Met Phe Phe Ser Lys 1 5 10 Val Gly Asp Phe Ile Glu Lys His Tyr Arg Val Lys Thr Leu Ala 25 Val Phe Leu Leu Val Val Gly Val Phe Leu Phe Leu Glu Gly Leu 40 Leu His Ile Asn Lys Asn Tyr Leu Tyr Ala Gly Ile Gly Phe Ala 55 Leu Ile Glu Cys Leu Unk Ile Phe Ile Glu Lys Lys Met Lys Lys 65 70 75 INFORMATION FOR SEQ ID NO:712: SEQUENCE CHARACTERISTICS: LENGTH: 141 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...141 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:712 Met Glu Ser Asn Gin Ser Leu Pro Met Ala Leu Ile Ser Cys Ser 1 5 10 Asn Ala Lys Gly Ala Asp Ile Lys Gly Tyr Asn Gly Leu Val Gly 25 Leu Ile Glu Arg Asn Phe Gin Arg Tyr Gly Val Pro Leu Leu Leu 40 Thr Leu Thr Asn Gly Leu Leu Ile Gly Ile Thr Ser Ala Leu Asn 55 Arg Gly Asn Lys Glu Glu Val Thr Asn Phe Phe Gly Asp Tyr Leu 70 75 Leu Gin Leu Met Arg Gin Ser Gly Met Gly Ile Asn Gin Val Val 90 Ile Phe His Leu Ser Pro Glu Ser Asn Leu Asn 594 Gin Ile Leu Arg Asp Lys Ser Lys Ile Ala Pro Ile Val Val Ile Arg 100 105 110 Glu Gly Ser Arg Val Phe Ile Ser Pro Asn Thr Asp Ile Phe Phe Pro 115 120 125 Ile Pro Arg Glu Asn Glu Val Ile Ala Glu Phe Leu Lys 130 135 140 INFORMATION FOR SEQ ID NO:713: SEQUENCE CHARACTERISTICS: LENGTH: 51 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...51 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:713 Val Asn Phe Tyr Leu Ser Pro Lys Asp Tyr His His Tyr His Ala Pro 1 5 10 S Cys Asp Leu Glu Ile Leu Glu Ala Arg Tyr Phe Ala Gly Lys Leu Leu 25 Pro Val Asn Lys Pro Ser Leu His Lys Lys Gin Asn Leu Phe Val Gly 35 40 Asn Glu Arg INFORMATION FOR SEQ ID NO:714: SEQUENCE CHARACTERISTICS: LENGTH: 233 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...233 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:714 Met Asp Ile Leu Lys Ala Glu His Leu Asn Lys Gin Ile Lys Lys Thr 1 5 10 Lys Ile Val Ser Asp Val Ser Leu Glu Val Lys Ser Gly Glu Val Val 25 Gly Leu Leu Gly Pro Asn Gly Ala Gly Lys Thr Thr Thr Phe Tyr Met 40 Ile Cys Gly Leu Leu Glu Pro Ser Gly Gly Ser Val Tyr Leu Asn Asp 55 Val Asp Leu Ala Lys Tyr Pro Leu His Lys Arg Ser Asn Leu Gly Ile 70 75 Giy Tyr Leu Pro Gin Giu Ser Ser Ile Phe Lys Glu Leu Ser Val Giu 90 Glu Asn Leu Ala Leu Ala Gly Glu Ser Thr Phe Lys Asn Ser Lys Glu 100 105 110 Ser Glu Glu Lys Met Glu Ser Leu Leu Asp Ala Phe Asn Ile Gin Ala 115 120 125 Ile Arg Glu Arg Lys Gly Met Ser Leu Ser Gly Gly Giu Arg Arg Arg 130 135 140 Val Glu Ile Ala Arg Ala Leu Met Lys Asn Pro Lys Phe Val Leu Leu 145 150 155 160 Asp Giu Pro Phe Ala Gly Val Asp Pro Ile Ala Val Ile Asp Ile Gin 165 170 175 Arg Ile Ile Glu Ser Leu Ile Gly Leu Asn Ile Gly Val Leu Ile Thr 180 185 190 Asp His Asn Val Arg Glu Thr Leu Ser Val Cys His Arg Ala Tyr Val 195 200 205 Ile Lys Ser Gly Thr Leu Leu Ala Ala Gly Thr Leu Met Lys Phe Met 210 215 220 Lys Thr Leu Trp Cys Val Ser Ile Ile 225 230 INFORMATION FOR SEQ ID NO:715: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 265 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein a (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAMEIKEY: misc feature LOCATION .265 (xi) SEQUENCE DESCRIPTION: SEQ ID N0:715 Met Ile Lys Ala Arg Phe Lys Lys Arg Leu Leu Gly Ser Arg Gly Ala 1 5 10 ::Phe Asp Leu Asn Ile Asp Leu Glu Ile Lys Giu Ala Glu Val Val Ala 25 Leu Leu Gly Giu Ser Gly Ala Gly Lys Ser Thr Ile Leu Arg Ile Leu 40 Ala Gly Leu Giu Ala Val Sen Ser Gly Tyr Ile Giu Ala Asn His Ser 5-5 Val Trp Leu Asp Thr Gin Lys Lys Ile Phe Leu Lys Pro Gin Gin Arg 70 75 Lys Ile Gly Phe Val Phe Gin Asp Tyr Ala Leu Phe Pro His Leu Asn 90 Val Tyr Gin Asn Ile Ala Phe Ala His Pro Lys Asp Lys Asn Lys Ile 100 105 110 His Giu Val Leu Arg Leu Met Arg Leu Giu Asn Leu Ser Gin Gin Lys 115 120 125 Ie Pro Lys Leu Ser Gly Gly Gin Ala Gin Ang Val Ala Leu Ala Arg 130 135 140 Ala Leu Ile Ala Ala Lys Asn Leu Leu Leu Leu Asp Giu Pro Leu Asn 145 150 155 160 Ala Phe Asn Val Val 225 Pro Leu Asp Lys lIe 195 Asp Pro Thr Phe 596 Gin Gin Leu Val Leu Phe Phe Ser 220 Cys His 235 Leu Asn Leu His 190 Asn Arg Glu Thr Leu 175 Asp Asn Leu Val Phe 255 INFORMATION FOR SEQ ID NO:715: SEQUENCE CHARACTERISTICS: LENGTH: 265 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION .265 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:715
S
*5S* .5.5 Met Ile Lys Ala Arg Phe Lys Lys Arg Leu Leu Gly Ser Arg .1* 1 Phe Leu Ala Val
LS
Lys Val His Ile Ala 145 Ala Phe Asn Val Asp Leu Gly Trp Ile Glu Pro 130 Leu Leu Ile Glu Ile Leu Gly Leu Leu Gly Gin Val 115 Lys Ile Asp Lys Ile 195 Asp Asn Glu Glu Asp Phe Asn 100 Leu Leu Ala Asn Arg 180 Thr Pro 5 Ile Ser Ala Thr Val 85 Ile Arg Sen Ala Ala 165 Glu Lys Asn Asp Gly Val Gin 70 Phe Ala Leu Gly Lys 150 Leu Asn Leu Gin Leu Ala Ser 55 Lys Gin Phe Met dly 135 Asn Lys Leu Ala Glu Glu Gly 40 Ser Lys Asp Ala Arg 120 Gin Leu Asn Sen Arg 200 Asn Ile 25 Lys Gly Ile Tyr His 105 Leu Ala Leu Glu Val 185 Thr Arg 10 Lys Ser Tyr Phe Ala 90 Pro Glu Gln Leu Va1 170 Leu Phe Leu Glu Thr Ile Leu 75 Leu Lys Asn Arg Leu 155 Gin Leu Leu Phe Ala Ile Glu Lys Phe Asp Leu Val 140 Asp Gin Va1 Phe Sen Glu Leu Ala Pro Pro Lys Ser 125 Ala Glu Gly Ser Leu 205 Asn Val Arg Asn Gin His Asn 110 Gin Leu Pro Leu His 190 Asn Arg Gly Val Ile His Gin Leu Lys Gln Ala Leu Leu 175 Asp Asn Leu Ala Ala Leu Ser Arg Asn Ile Lys Arg Asn 160 Asp Pro Gly Leu 210 215 220 Val Lys Pro Leu Phe.Glu Asp Giu Asn Tyr Cys His Tyr Giu Val Ile 225 230 235 240 Pro Gin Thr Ile Ser Leu Pro Lys Asp Cys Leu Asn Pro Thr Phe Lys 245 250 255 Leu Asp Phe Ile Gin Asn Lys Lys Phe 260 265 INFORMATION FOR SEQ ID NO:716: SEQUENCE CHARACTERISTICS: LENGTH: 158 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...158 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:716 0Met Lys Glu Ile Val Thr Ile Glu Asn Val Ser Phe Asn Tyr His Asn 1 5 10 Arg Ala Ile Phe Lys Asp Phe Asn Leu Ser Ile Gin Glu Gly Asp Phe :*20 25 Leu Cys Val Leu Gly Glu Ser Gly Ser Gly Lys Ser Thr Leu Leu Gly 35 40 Leu Ile Leu Gly Leu Leu Lys Pro Ser Leu Gly Ser Val Lys Ile Phe 55 Asn Glu Thr Leu Ser Asn Asn Ala Phe Leu Arg Gin Lys Ile Gly Tyr 70 75 Ile Ala Gin Gly Asn Ser Leu Phe Pro His Leu Asn Ala Leu Gin Asn 85 90 Met Thr Phe Cys Leu Asn Leu Gin Gly Ile Asn Lys Gin Ala Ala Gin 100 105 110 Lys Glu Ala Lys Ala Leu Ala Leu Lys Met Gly Leu Asp Glu Ser Leu 115 120 125 Met Asp Lys Phe Pro Asn Glu Leu Ser Gly Gly Gin Ala Lys Glu Trp 130 135 140 Ala Leu Leu Gly Gly Leu Ser Thr Gly Gin Asn Ser Phe Tyr 145 150 155 INFORMATION FOR SEQ ID NO:717: SEQUENCE CHARACTERISTICS: LENGTH: 191 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .191 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:717 Met Ilie Phe Pro Glu Arg Phe Gin Asn Ala Phe Leu Gly Leu Ser Giu i 10 Leu Phe Tyr Tyr Ala Ser Ser Leu Ser Phe Tyr Thr Ile Leu Ser Leu 25 Ser Pro Ile Leu Leu Phe Val Phe Ser Leu Phe Val Ser His Tyr Leu 40 Gin Ala His Ser Gly Giu Met Glu Ala Leu Ile Phe Pro Asn Ala Pro 55 Lys Leu Ile Gly Aia Ile Lys Asp Phe Leu Glu Asn Phe Lys Lys Thr 70 75 Asp Met Thr Leu Gly Thr Leu Glu Glu Val Ser Ile Val Val Ala Leu 90 Val Leu The Cys Giu Asn Tyr Arg Ser Ile Ala Ser Lys Ile Phe Asp 100 105 110 Ala Lys Pro Arg Asp Tyr Ala His Phe Lys Gly Lys Glu Ile Phe Leu 115 120 125 Phe Trp Gly Phe Gly Thr Thr Leu Val Phe Leu Phe Ala Leu Pro Leu 130 135 140 Vai Vai Phe Phe Asp Ile Lys Ile Gin Val Phe Phe Glu Asp Lys Asp 145 150 155 160 Ser Ser Leu Leu His Val Leu Arg Trp Ile Gly Thr Tyr Ala Phe Phe 165 170 175 Leu Ile Leu Phe Thr Ile Pro Thr Asn Lys Val Phe Lys Leu Lys 000180 185 190 0(2) INFORMATION FOR SEQ ID NO:718: (i)SEQUENCE CHARACTERISTICS: :0 LENGTH: 243 amino acids TYPE: amino acid TOPOLOGY: linear ,00a.
.0 (ii) MOLECULE TYPE: protein (iii) HYPOT HET ICAL: YES :*00*0(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .243 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:718 Met Val Leu Met Ile Phe Thr Ser Ile Leu Lys Ile Ala Leu Lys Val 1 5 10 Leu Sen Giu Arg Lys Lys Asn Arg Tyr Gly Phe Pro Arg Ile Phe Asp 25 Val Ala Asp Ile Giu Gin Giu Glu Arg Glu Val Ile Giu Trp Arg Giu 40 Lys Lys Lys Ala Sen Lys Gin Ser Tyr Lys Gin Asn Leu Gin Ile Asn s0 55 Lys Ile Ala Asn Asp Leu Lys Arg Asp Lys Ile Val Asp Lys Arg Thr 70 75 Ile Leu Sen Val Ile Asp Ala Asp Ile Giu Arg Gly Phe Ile Pro Pro 90 Lys Asp Leu Leu Lys Gin Leu Glu Lys Ile Ser Ala Sen Leu Sen Lys 100 105 110 Asp Ile Val Ile Thr Ile Lys Gin Val Glu Lys Leu Glu Leu Asn Tyr 115 120 125 Ala Leu Ile Asp Asn Ile Gin His Asn Thr Leu Asp Asp Thr Leu Asp 130 135 140 Phe Thr Phe Ile Vai Gly Asp Ser Leu Ser Val Gin Ser Leu Tyr Vai 145 i50 155 160 Thr Phe Asn Leu Val Ile Asp Ile Asp Arg Pro Met Ser Giu Gin Phe 165 170 175 Leu Asn Unk Ile Giy Lys Leu Giy Ser Phe Giu Ser Arg Giu Gin Ala 180 185 190 Leu Giu Trp, Vai Arg Leu Ser Gin Thr Lys Leu Ile Ile Giu Thr Pro 195 200 205 Lys Giu Ala Leu Lys Asn Ala Glu Leu Ser Gin Ile Giu Giu Ile Leu 210 215 220 Thr Gly Cys Ile Phe Asn Giy Ala Tyr Arg Leu Gin Asn Asp Leu Lys 225 230 235 240 Lys Giy Arg INFORMATION FOR SEQ ID NO:7i9: SEQUENCE CHARACTERISTICS: LENGTH: 236 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein *(iii)HYOHTCLYE ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .236 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:719 Val Ser Glu Val Ala Ser Val Giy Gly Phe Val Lys Asp Tyr Giu Val 1 5 10 Tbz Leu Gin Asn Asp Ser Leu Ile Arg Tyr Asn Leu Ser Leu Giu Gin 25 Val Ala Asn Ala Ile Lys Asn Ser Asn Asn Asp Thr Gly Gly Gly Val 40 le Leu Glu Asn Gly Phe Glu Lys Ile Ile Arg Ser His Gly Tyr Ile 55 Gin Ser Leu Asn Asp Leu Giu Glu Ile Val Val Lys Lys Giu Gly Ala 70 75 Ile Pro Leu Lys Ile Lys Asp Ile Ala Ser Val Arg Leu Ala Pro Lys 90 Pro Arg Arg Gly Ala Ala Asn Leu Asn Gly Asp Lys Glu Val Val Gly 100 105 110 Gly Ile Val Met Val Arg Tyr His Ala Asp Thr Tyr Lys Val Leu Lys 115 120 125 Ala Ile Lys Glu Lys Ile Ala Thr Leu Gin Ala Ser Asn Pro Asp Val 130 135 140 Lys Ile Thr Ser Val Tyr Asp Arg Sen Glu Leu Ile Glu Lys Gly Ile 145 150 155 160 Asp Asn Leu Ile His Thr Leu Ile Giu Glu Ser Val Ile Val Leu Val 165 170 175 Ile Ile Ala Ile Phe Leu Leu His Phe Arg Ser Ala Leu Val Val Ile 180 185 190 Ile Tbr Leu Pro Leu Arg Val Cys Ile Ser Phe Leu Leu Met Sen Tyr 195 200 205 600 Phe Asn Ile Giu Ala Ser Ilie Met Ser Leu Gly Gly Ile Ala Ile Ala 210 215 220 Ile Gly Ala Met Val Asn Ala Ala Ilie Val Met Val 225 230 23S INFORMATION FOR SEQ ID NO:720: SEQUENCE CHARACTERISTICS: LENGTH: 175 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1. 175 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:720 Val Giu Thx Phe Leu Arg Ile Phe Giu Lys Asp Ile Phe Asn Thr Pro 1 5 10 Tyr Lys Leu Glu Val Ile Asn Ala Thr Giu Gly Gly Ala Arg Ile Lys Gl hrLs20 25 GlyThrLysGiu Met Pro Phe Lys Giu Val Cys Giu Lys Ile Asp Lys 0035 40 ***Ser Lys Pro Lys Pro Pro Ile Asn Leu Ile Tyr Pro Thr Gin Sen Giu 55 Gin Ala Lys Asn Leu Lys Ile Ala Lys Lys Lys Cys Glu Giu Ile Ile 70 75 *Lys Tyr Ala Asn Giu Lys Lys Thr Gin Val Giu Giu Ala Phe Leu Lys 90 Val Ala Glu Phe Leu Giu Lys Val Giu Lys Leu His Giu Lys Asn Lys 100 105 110 Leu Giu Giu Leu Asp Phe Giu Giu Leu Giu Asn Leu Ser Ala Glu Ile 115 120 125 Asp Asn Val Lys Giu Leu Phe Asp Asp Lys Arg Phe Asn Sen Tyr Phe 130 135 140 Met Asp Ala Ile Gin Sen Tyr Ile Phe His Gin Giu Leu His Ile Ala 145 150 155 160 :*:Glu Ile Val Cys Lys Lys Thr Ser Asn Giu Asp Gly Ile Lys Giy 165 170 175 INFORMATION FOR SEQ ID NO:72i: SEQUENCE CHARACTERISTICS: LENGTH: 226 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...226 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:721 Met Lys Thr Pro Cys Asn Ala Tyr Phe Leu Lys Thr Pro Pro Lys Asn 1 5 10 Lys Lys Arg Arg Val Tyr Val Asn Leu Ala Val Phe Leu Phe Leu Leu 25 Leu Ala Ser Ala Leu Trp Leu Ile Pro Arg Ser Ala Ile Glu Unk Lys 40 Pro Leu Val Val Ala Thr Lys Pro Ser Ser Glu Gin Tyr Ile Leu Gly 55 Glu Ile Leu Ser Leu Leu Leu Glu Lys His His Ile Pro Ile Lys Arg 70 75 Ala Phe Gly Ile Gly Gly Gly Thr Met Asn Ile His Pro Ala Leu Ile 90 Arg Gly Asp Phe Asp Leu Tyr Val Glu Tyr Thr Gly Thr Ala Trp Val 100 105 110 Asn Thr Leu Lys Asn Pro Leu Thr Gin Lys Val Asp Phe Glu Thr Ile 115 120 125 Lys Lys Arg Tyr Glu Lys Glu Phe Asn Leu Leu Trp Val Gly Leu Leu S130 135 140 S Gly Phe Asn Asn Thr Tyr Ser Leu Ala Ile Ser Lys Glu Asp Ala Gin 145 150 155 160 Lys Tyr Ala Ile Glu Thr Phe Ser Asp Leu Ala Phe His Ser Pro Asn 165 170 175 Phe Asp Phe Gly Ala Glu Unk Asp Phe Phe Glu Arg Glu Asp Ala Phe 180 185 190 Lys Gly Leu Ile Lys Ala Tyr Arg Phe His Phe Arg Ser Leu His Glu 195 200 205 Met Unk Ile Asn Leu Arg Tyr Lys Ser Phe Glu Ser Leu Ile Arg Unk *'*210 215 220 Thr Leu 225 INFORMATION FOR SEQ ID NO:722: SEQUENCE CHARACTERISTICS: LENGTH: 79 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...79 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:722 Val Met Val Tyr Lys Leu Pro Lys His Gin Gin Asn Lys Val Met Ile 1 5 10 Leu Gly Leu Gly Leu Ala Met Ile Thr Arg Ile Gly Leu Leu Gly Ser 25 Leu Phe Phe Ile Ser His Leu Gin Lys Pro Leu Phe Ala Ile Ala Gly 40 Met Ser Phe Ser Trp Arg Asp Val Val Leu Leu Leu Gly Gly Ala Phe 55 602 Leu Ala Phe Lys Ala Leu Val Glu Leu Lys Arg Ala Asp Leu Ser 70 INFORMATION FOR SEQ ID NO:723: SEQUENCE CHARACTERISTICS: LENGTH: 64 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...64 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:723 Val Lys Phe Ser Val Leu Thr Leu Phe Pro Gin Leu Ile Leu Pro Tyr 1 5 10 Phe Glu Asp Ser Ile Leu Lys Arg Ala Leu Glu Lys Asn Leu Phe Glu 25 Leu Glu Val Leu Asn Leu Arg Asp Phe Ser Ala Asn Lys Tyr Gin Lys 35 40 Ala Unk Ser His Ala His Trp Trp Gly Cys Gly Ala Asn Phe Arg Pro 50 55 INFORMATION FOR SEQ ID NO:723: SEQUENCE CHARACTERISTICS: LENGTH: 64 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...64 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:723 Val Lys Phe Ser Val Leu Thr Leu Phe Pro Gin Leu Ile Leu Pro Tyr 1 5 10 Phe Glu Asp Ser Ile Leu Lys Arg Ala Leu Glu Lys Asn Leu Phe Glu 25 Leu Glu Val Leu Asn Leu Arg Asp Phe Ser Ala Asn Lys Tyr Gin Lys 40 Ala Unk Ser His Ala His Trp Trp Gly Cys Gly Ala Asn Phe Arg Pro 55 INFORMATION FOR SEQ ID NO:724:
I
SEQUENCE CHARACTERISTICS: LENGTH: 138 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...138 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:724 Leu Trp Arg Thr Pro Lys Thr Pro Leu Val Ile Lys Pro Tyr Leu Lys 1 5 10 Ser Met Ser Asp Ser Glu Ile Phe Ala Unk Unk Cys Val Gly Met Ala 20 25 Ser Val Unk Gly Pro Val Leu Ala Gly Tyr Ala Ser Met Gly Ile Pro 35 40 Leu Pro Tyr Leu Ile Ala Ala Ser Phe Met Ser Ala Pro Gly Gly Leu 55 Leu Phe Ala Lys Thr Ile Tyr Pro Gin Asn Glu Thr Ile Ser Ser His 70 75 Ala Asp Val Ser Ala Glu Glu His Val Asn Ile Ile Glu Ala Unk Ala 85 90 Unk Gly Ala Ser Thr Gly Unk His Leu Ala Leu His Val Gly Ala Met 100 105 110 Leu Leu Ala Phe Val Gly Met Val Ala Leu Val Asn Gly Leu Leu Gly 115 120 125 Val Val Gly Gly Phe Leu Gly Met Glu His 130 135 INFORMATION FOR SEQ ID NO:724: SEQUENCE CHARACTERISTICS: LENGTH: 138 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...138 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:724 Leu Trp Arg Thr Pro Lys Thr Pro Leu Val Ile Lys Pro Tyr Leu Lys 1 5 10 Ser Met Ser Asp Ser Glu Ile Phe Ala Unk Unk Cys Val Gly Met Ala 25 Ser Val Unk Gly Pro Val Leu Ala Gly Tyr Ala Ser Met Gly Ile Pro 40 I I 604 Leu Pro Tyr Leu Ile Ala Ala Ser Phe Met Ser Ala Pro Gly Gly Leu so 55 Leu Phe Ala Lys Thr Ile Tyr Pro Gln Asn Glu Thr Ile Ser Ser His 70 75 Ala Asp Val Ser Ala Glu Glu His Val Asn Ile Ile Glu Ala Unk Ala 90 Unk Gly Ala Ser Thr Gly Unk His Leu Ala Leu His Val Gly Ala Met 100 105 110 Leu Leu Ala Phe Val Gly Met Val Ala Leu Val Asri Gly Leu Leu Gly 115 120 125 Val Val Gly Gly Phe Leu Gly Met Glu His 130 135 INFORMATION FOR SEQ ID NO:725: Ci) SEQUENCE CHAR.ACTERISTICS: LENGTH: 210 amino acids too* TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .210 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:725 Met Phe Val Val Phe Ile Giu Gly Phe Gly Le u Ala Ile Ser Leu Cys Ala Ala Val Gly Ala Gin Sen Leu Phe Ile Val Giu Arg Gly Met Ala 25 Ang Asn Tyr Val Phe Leu Ile Cys Ala Leu Cys Phe Met .Cys Asp Ile .35 40 Val Leu Met Sen Met Giy Val Phe Gly Val Giy Ala Tyr Phe Ala Lys 55 Asn Leu Tyr Leu Sen Leu Phe Leu Asn Leu Phe Gly Ala Val Phe Thr 70 75 Gly Phe Tyr Ala Phe Leu Ala Leu Lys Thr Leu Phe Gin Thr Phe Lys 90 Lys Lys Gin Val Gin Thr Pro Lys Lys Leu Ser Leu Lys Lys Thr Leu 100 105 110 Leu Phe Thr Leu Gly Val Thr Leu Leu Asn Pro Gin Val Tyr Leu Giu 115 120 125 Met Val Phe Leu Ile Gly Ala Ser Ala Met Sen Phe Asn Leu Val Gin 130 -135 140 Lys Phe Val Phe Leu Ala Gly Thr Leu Sen Ala Ala Phe Sen Trp Leu 145 150 155 160 *Leu Leu Leu Cys Thr Met Sen Leu Arg Tyr Gly Ser Lys Leu Leu Asn 165 170 175 Asn Gin Lys Ile Phe Met Giy Val Asn Leu Phe Val Thr Ala Ile Met 180 185 190 Gly Thr Leu Ser Val Thr Leu Phe Arg Asp Phe Leu Ala Leu Leu Sen 195 200 205 Lys Thr 210 INFORMATION FOR SEQ ID NO:726: SEQUENCE CHARACTERISTICS: LENGTH: 296 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...296 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:726
S
S5 S S Val 1 Ile Asp Leu Gin Ala Asn Pro Glu Val 145 Arg Leu Tyr Val Phe Lys Leu Asp Lys 50 Ile Tyr Gly Lys Met 130 Ile Arg Thr Leu His 210 Leu Pro Lys Ser Met Lys Glu Lys Leu Arg Gly Ala Met Val Asn Arg Ala 35 Pro Gin Pro Ala Ser 115 Leu Leu Leu Glu Lys 195 Tyr Ser Ile Leu Ile Ala Gin Asn 100 Leu Met Ile Leu Ser 180 Val Asn Gly Met Ser 260 Phe 5 Lys Asp Ile Gin Phe Met Tyr Arg Asp Asp 165 Lys Asn Glu Val Arg 245 SGlu Phe Met Lys Ser Phe 70 Leu Glu Ile Leu Ala 150 Lys Glu Leu Asn Asp 230 Phe Lys Ile Val Pro 55 Thr Ser Phe Glu Leu 135 Leu Asn Ile Gin Ala 215 Ala Gly Asn Glu Val 40 Ile Asp Cys Leu His 120 Ser Ser Asn Glu Glu 200 Lys Leu Ser Asn Ile 25 Ala Glu Ala Gly Leu 105 Glu Ser Leu Asp Glu 185 Lys Asp Ser Lys SGin 265 Thr 10 Ser Lys Asp Pro Leu 90 Pro Lys Ala Gly Phe 170 Ala Leu Ser Lys Asn 250 SSer Ser Glu Lys Tyr Lys 75 Leu Lys Asp Pro Gly 155 Ile Leu Ala Leu Asp 235 Gly Ala Phe Trp Glu Gin Phe Gin Val Gly Leu 140 Ile Tyr Lys Gly Pro 220 Ala Val Glu SGlu Leu Gn Pro Glu Lys Ser Asn Glu Val Arg Tyr Pro 110 Gin Phe 125 Val Gin Phe Asn Gin Gin His Leu 190 Phe Arg 205 Leu Lys Leu Tyr Leu Ser Asp Leu 270 iUnk Leu Lys Ser Val Glu Gly Phe Leu Leu Leu Arg 175 His Asp Ala Tyr Phe 255 Lys Lys Leu Phe Arg Gly Lys Pro Arg Glu Ala 160 Ile Glu Phe Leu Leu 240 Val Arg Tyr Glu Lys Ile Asn Leu Glu Tyr Ala Glu 275 Lys Asp Arg 280 Leu Asn 290 Val Glu Ile Ile Ser Asp 295 INFORMATION FOR SEQ ID NO:727: SEQUENCE CHARACTERISTICS: LENGTH: 94 amino acids TYPE: amino acid TOPOLOGY: linear 606 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1 .94 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:727 Val Leu Ile Ser Val Met Ile Gly Gin Asn Gin Vai Leu Gly Phe Ile 1 5 10 Giy Thr Asn Phe Lys Gin Giu Leu Val Val Asp Phe Ile Val Pro Ser 25 Ala Giu Ile Asn Ile Gly Asn Gin Val Ile Thr Ser Gly Leu Asp Gly '00,35 40 Ile Phe Giy Aia Gly Val Phe Val Gly Glu Val Sen Ser Val Giu Asp so* 5 55 His Tr Thr Tyn Lys Sen Ala Val Leu Lys Asn Ala Phe Leu Ser Giu 65 70 75 Ala Lys Leu Leu Ang His Val Phe Leu Ser Gly Val Lys Asn INFORMATION FOR SEQ ID NO:728: SEQUENCE CHARACTERISTICS: LENGTH: 83 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc...feature, LOCATION .83 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:728 Met Glu Aia Gin Leu Arg Phe Thr Gly Val Gly Gly Gin Gly Vai Leu 1 5 10 Leu Ala Gly Giu Ile Leu Ala Glu Ala Lys Ile Val Ser Gly Gly Tyr 25 Giy Thr Lys Thr Ser Thr Tyr Thn Sen Gin Val Arg Gly Gly Pro Thr 40 Lys Val Asp Ile Leu Leu Asp Lys Asp Glu Ile Ile Phe Pro Tyr Ala 55 Lys Glu Gly Giu Ile Asp Phe Met Leu Ser Val Ala Gin Ile Ser Tyr 70 75 Asn Gin Phe INFORMATION FOR SEQ ID NO:729: SEQUENCE CHARACTERISTICS: LENGTH: 203 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...203 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:729 Met Gln Ala Trp Val Asp Lys Pro Val Leu Leu Glu Pro Asp Ser Asn 1 5 10 Ala Gin Tyr Ala Ala Val Ile Glu Ile Asp Val Ala Glu Ile Thr Glu 20 25 Pro Ile Leu Ala Cys Pro Asn Asp Pro Asp Asp Val Ala Thr Leu Ser 35 40 Glu Val Leu Ala Asp Thr Thr Gly Lys Arg Pro His Ala Ile Asp Glu 50 55 Val Phe Ile Gly Ser Cys Met Thr Asn Ile Gly His Phe Arg Ala Phe 70 75 Gly Glu Ile Val Lys Asn Ala Pro Pro Ser Gin Ala Arg Leu Trp Val 90 Val Pro Pro Ser Lys Met Asp Glu Gln Glu Leu Ile Asn Glu Gly Tyr S* 100 105 110 Tyr Ala Ile Phe Gly Ala Ala Gly Ala Arg Thr Glu Val Pro Gly Cys 115 120 125 Ser Leu Cys Met Gly Asn Gin Ala Arg Val Arg Asp Asn Ala Val Val 130 135 140 Phe Ser Thr Ser Thr Arg Asn Phe Asp Asn Arg Met Gly Arg Gly Ala 145 150 155 160 Lys Val Tyr Leu Gly Ser Ala Glu Leu Gly Ala Ala Cys Ala Leu Leu 165 170 175 S, Gly Arg Ile Pro Thr Lys Glu Glu Tyr Met Asn Leu Val Ser Glu Lys S180 185 190 Leu Glu Ser Gin Lys Asp Lys Ile Tyr Arg Ser 195 200 INFORMATION FOR SEQ ID NO:730: SEQUENCE CHARACTERISTICS: LENGTH: 220 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...220 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:730
I
Val Gly Asn Ala Gly Val Ala Leu Ala Gly Leu Met Ser Asp Glu Ile 1 5 10 Tyr Leu Cys Ala Leu Asp Cys Ala Tyr Ile Lys Gly Phe Lys Lys His 25 Ala Gin Asn Ser Tyr Tyr Gly Asp Glu Lys Glu Ile Asp Thr Ser Ser 40 Leu Ile Ser Val Glu Gly Asn Val Glu Gly Tyr Glu Thr Phe Ser Asp 55 Ser Leu Phe Leu Leu Ser Lys Glu Arg Ile Glu Glu Ala Leu His Tyr 70 75 Tyr Gin Pro Lys Lys Val Tyr Asn Leu Ser Tyr Gly Ala Lys Ile Lys 90 His Ala Val Ser Leu Asn His Ser Gin Val Lys Leu Lys Gin Ile Asn 100 105 110 Lys Gin Asp Ala Ile Val Arg Ile Lys Ser Met Phe Ser Pro Arg Ser 115 120 125 Asn His Ala Lys Asp Leu Lys Asn Leu Gln Lys Asn Leu Ile Arg Phe 130 135 140 Lys Glu Asp Phe Phe Thr His Leu Asn Thr Pro Cys Lys Thr Lys Gin 145 150 155 160 Glu Ala Phe Glu Trp Val Asp Ser Leu Ser Gly Phe Cys Gin Thr Ala 165 170 175 Ser Ala Lys Thr Pro Thr Ile Gly Ile Leu Phe Glu Gly Ser Val Ala 180 185 190 His Ile Leu Gin Ser Val Leu Ile Val Ser Leu His Leu Lys Glu Asn 195 200 205 Glu Leu Thr Leu Leu Ser Asn Ser Leu Lys Thr Pro 210 215 220 INFORMATION FOR SEQ ID NO:731: SEQUENCE CHARACTERISTICS: LENGTH: 116 amino acids TYPE: amino acid TOPOLOGY: linear S(ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...116 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:731 Val Met Asn Phe Phe Val Gly Gly Leu Ser Ile Val Cys Asn Val Val 1 5 10 Val Ile Thr Tyr Ser Ala Leu His Pro Thr Ala Pro Val Glu Gly Ala 25 Glu Asp Ile Val Gin Val Ser His His Leu Thr Ser Phe Tyr Gly Pro 40 Ala Thr Gly Leu Leu Phe Gly Phe Thr Tyr Leu Tyr Ala Ala Ile Asn 55 His Thr Phe Gly Leu Asp Trp Arg Pro Tyr Ser Trp Tyr Ser Leu Phe 70 75 Val Ala Ile Asn Thr Val Pro Ala Ala Ile Leu Ser His Tyr Ser Asp 90 Met Leu Asp Asp His Lys Val Leu Gly Ile Thr Glu Gly Asp Trp Trp 100 105 110 Ala Ile Ile Unk 609 INFORMATION FOR SEQ ID NO:731: SEQUENCE CHARACTERISTICS: LENGTH: 116 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...116 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:731 Val Met Asn Phe Phe Val Gly Gly Leu Ser Ile Val Cys Asn 1 5 10 Val Ile Thr Tyr Ser Ala Leu His Pro Thr Ala Pro Val Glu 25 Glu Asp Ile Val Gin Val Ser His His Leu Thr Ser Phe Tyr 35 40 Ala Thr Gly Leu Leu Phe Gly Phe Thr Tyr Leu Tyr Ala Ala 50 55 His Thr Phe Gly Leu Asp Trp Arg Pro Tyr Ser Trp Tyr Ser 70 Val Ala Ile Asn Thr Val Pro Ala Ala Ile Leu Ser His Tyr 85 90 Met Leu Asp Asp His Lys Val Leu Gly Ile Thr Glu Gly Asp 100 105 110 Ala Ile Ile Unk 115 Val Gly Gly Ile Leu Ser Trp INFORMATION FOR SEQ ID NO:732: SEQUENCE CHARACTERISTICS: LENGTH: 248 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE:- ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...248 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:732 Met Gin Lys Ser Ile Phe Lys Ile Thr Leu Leu Leu Val Phe Leu Phe 1 5 10 Leu Arg Asn Ala Val Gly Leu Asp Asp Lys Lys Ala Ala Pro Lys Ser 25 Val Gin Thr Glu Leu Cys Tyr His 145 Lys Lys Pro Glu Lys 225 Asn Gin Ala Gin Glu Ile Tyr ile 130 Glu Ser Ile Ser Glu 210 Glu Lys Asn Tyr Tyr Trp Ser Glu 115 Glu Met Glu Pro Lys 195 Lys Glu Pro Thr Glu Glu Leu Pro 100 Ala Gly Ala Asn Lys 180 Asp Asp Ala Ala Pro Asp Phe Gly Lys Tyr Lys Leu Lys 165 Gly Phe Ser Leu Leu 245 Lys Leu Pro 70 Val Ala Val Lys Asn 150 Lys Tyr Leu Leu Lys 230 Val Asn Ile 55 Lys Ala Ser Lys Val 135 Lys Gly Tyr Gin Thr 215 Gin Glu Leu 40 Lys Ile His Ile Gin 120 Lys Ser Leu Leu Thr 200 His Leu Lys Pro Met Lys Glu Glu 105 Arg Arg Gin Thr Gin 185 Leu Tyr Glu Pro Leu Glu Glu 90 Asn Ile Lys Pro Lys 170 Ile Lys Leu Asn 610 Ile Gln Asp Asn Ile Leu 75 Cys Val Ser Pro His Asp Ile Lys 140 Leu Lys 155 Pro Ser Gly Ala Thr Phe Ile Gly 220 Ala Ala 235 Leu Met Glu Ala Ile Leu 125 Lys Lys Leu Phe Pro 205 Pro Lys Arg Gly Gin Leu Tyr 110 Tyr Ala Glu Lys Leu 190 His Tyr Ser Leu Lys Ser Val Lys Asp His Pro Asp 175 Asn Gin Lys Phe Asp Ser Glu Met Asn Phe Glu Pro 160 Ala Ser Met Thr Lys 240 INFORMATION FOR SEQ ID NO:733: SEQUENCE CHARACTERISTICS: LENGTH: 150 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...150 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:733 Met Gin Glu Ile Leu Ile Pro Leu Lys Glu Lys Ser Tyr Lys 1 5 10 Leu Gly Glu Leu Pro Glu Ile Lys Leu Lys Gln Lys Ala Leu 25 Ser Asp Ser Ile Val Ala Gly Leu His Leu Pro Tyr Leu Leu 40 Leu Asn Ala Leu Glu Val Arg Val Cys Val Ile Glu Ser Gly 55 Tyr Lys Asn Phe His Ser Leu Glu Arg Ile Leu Asn Asn Ala 70 75 Met Gln Leu Asn Arg His Ser Leu Met Ile Ala Leu Gly Gly 90 Ile Ser Asp Met Val Gly Phe Ala Ser Ser Ile Tyr Phe Arg 100 105 110 Asp Phe Ile Asn Ile Pro Tyr Asp Phe Thr Arg Ser Ser Gly Val Ile Glu Glu Phe Gly Gly Cys Phe Ile Arg Lys Glu Val Ile Glu
I
115 120 125 Arg Gly Gly Glu Asn Arg Asp Gin His Ala Leu Trp Gin Glu Pro Asfl 130 135 140 Arg Ile Val Pro Pro Ala 145 150 INFORMATION FOR SEQ ID NO:734: SEQUENCE CHARACTERISTICS: LENGTH: 227 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE-.
NAME/KEY: misc-feature LOCATION .227 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:734 Val Ala Glu Phe Ile Asp Giu Ser Glu Leu 145 Asn Leu Un]k Phe Lys 225~ Leu Leu Ile Pro 50 Pro Ala Val Val Ile 130 Lys Asn Ala *Ala 210 Arg Sen I'hr Lys Lys Gly I le dly 115 Ala dly Leu Gly Ala 195 Asn Leu 5 Phe Gly Ser Asn Lys Leu Asp Phe Val Phe Leu Thr 100 Ile Asn Arg Asp Ala Asn Gly Ser 165 Leu Ile 180 Ile Asn Unk Unk Sen Asn Sen Lys 70 Tyr Pro Ile Phe Thr 150 Val1 Val1 Ala Ala Gly Lys Ala 55 Lys His His Ser Ser 135 Leu Ala Ser Sen Leu 215 Val Pro 40 Phe Trp Lys Pro Met 120 Gin Ile Leu Leu Leu 200 Val1 25 Leu Ala Leu G iu Lys 105 Leu Lys Ala Ala Leu 185 Ala 10 Sen Glu Leu G iu Val 90 G lu Glu Tyr His
LYS
170 Ser His Ile Leu Gly Leu 75 Leu Phe Leu Pro Gin 155 Ala Gin Ala Gin Val Met Ala Gin Leu Leu Lys 140 Gly *Gly *Asn *Leu Leu 220 Ala Phe Gly Pro Ala Ser Asp 125 Val1 Arg Ser Ala 205 Ile Leu Cys Leu Cys Leu Leu 110 Asn Val Val Gly Thr 190 Gly Glu is Glu Glu.
G lu Val G lu Leu Lys Leu Phe Asp 175 Pro Leu Lys Ueu Gly Lys His Ser Gly Ala Gly Leu Leu Ser Ala Leu Unk Cys Asn Asn Leu Lys Lys Leu Leu Ile 160 Val Leu Unk Urik Thr Pro Unk Asp INFORMATION FOR SEQ ID NO:734: SEQUENCE CHARACTERISTICS: LENGTH: 227 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...227 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:734 Val Leu Leu Gly Lys His Ser Gly Ala Gly Leu Leu Ser Ala Leu Unk 1 5 10 Ala Leu Ser Phe Gly Ser Gly Val Val Ser Ile Gin Ala Leu Glu Cys 25 Glu Ile Thr Ser Asn Asn Lys Pro Leu Glu Leu Val Phe Cys Glu Asn 40 Phe Pro Lys Lys Leu Ser Ala Phe Ala Leu Gly Met Gly Leu Glu Asn 55 Ile Pro Lys Asp Phe Lys Lys Trp Leu Glu Leu Ala Pro Cys Val Leu 70 75 Asp Ala Gly Val Phe Tyr His Lys Glu Val Leu Gin Ala Leu Glu Lys 90 Glu Val Ile Leu Thr Pro His Pro Lys Glu Phe Leu Ser Leu Leu Lys 100 105 110 Ser Val Gly Ile Asn Ile Ser Met Leu Glu Leu Leu Asp Asn Lys Leu 115 120 125 S.Glu Ile Ala Arg Asp Phe Ser Gin Lys Tyr Pro Lys Val Val Leu Leu 130 135 140 Leu Lys Gly Ala Asn Thr Leu Ile Ala His Gin Gly Arg Val Phe Ile 145 150 155 160 Asn Asn Leu Gly Ser Val Ala Leu Ala Lys Ala Gly Ser Gly Asp Val 165 170 175 Leu Ala Gly Leu Ile Val Ser Leu Leu Ser Gin Asn Tyr Thr Pro Leu 180 185 190 Unk Ala Ala Ile Asn Ala Ser Leu Ala His Ala Leu Ala Gly Leu Unk 195 200 205 Phe Lys Asn Unk Unk Ala Leu Thr Pro Unk Asp Leu Ile Glu Lys Unk 210 215 220 Lys Arg Leu 225 INFORMATION FOR SEQ ID NO:735: S. SEQUENCE CHARACTERISTICS: LENGTH: 187 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...187 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:735 Met Arg Ile Leu His Tyr Gly Gly Glu Leu Pro Cys Asp Cys Pro Lys 1 5 10 Arg Ile Ala Gly Leu Asp Phe Ala LeU LYS Ile Leu Thr Asn Ile Thr 25 Ser Asp His Leu Asp Phe His Gln Asn Ile Giu Asn Tyr Arg Asp Ala 40 Lys Asn Ser The Phe Lys Asp Glu Gly Leu Lys Val Ile Asn Arg Asp 55 Giu Thr Asn Ala Leu Phe Asn Pro Ile Asn Ala Arg Thr Tyr Ala Leu 70 75 Asp Lys Lys Ala His Leu Asn Val Gin Ala Phe Ser Leu Asn Pro Ser 90 Ile Ser Ala Ser Leu Cys Tyr Gin His Asp Leu Arg Asp Pro Asn Leu 100 105 110 Lys Giu Thr Ala Leu Ile His Ser Pro Leu Leu Gly Arg Tyr Asn Leu 115 120 125 Tyr Asn Ile Leu Ala Gly Val Leu Gly Val Lys Leu Leu Thr Gin Leu 130 135 140 Pro Leu Giu Thr Ile Ala Pro Leu Leu Glu Asn Phe Tyr Gly Val Lys 145 150 155 160 Giy Arg Leu Giu Ile Val His Ser Lys Pro Leu Val Val Val Asp Phe 165 170 175 Ala His Thr Thr Asp Gly Met Gin Gin Val Phe 180 185 INFORMATION FOR SEQ ID NO:736.: SEQUENCE CHARACTERISTICS: LENGTH: 198 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyioriix) FEATURE: NAMEfKEY misc-feature LOCATION .198 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:736 Val Ser Ile Lys Glu Giu Ser Gin Thr Leu Ala Asp Ile Thr Phe Gin 1 5 10 Asn Tyr Phe Arg Met Phe Ser Lys Leu Ser Gly Met Thr Gly Thr Ala 25 Gin Thr Glu Ala Thr Glu Phe Leu Giu Ile Tyr Asn Leu Glu Val Val 40 Ser Ile Pro Thr Asn Leu Ala Ile Lys Arg Lys Asp Leu Asn Asp Leu 55 Ile Tyr Lys Ser Glu Lys Giu Lys Phe Asp Ala Val Ile Leu Lys Ile 70 75 Lys Glu Leu His Asp Lys Gly Gin Pro Val Leu Val Gly Thr Ala Ser 90 Ile Glu Lys Ser Giu Thr Leu His Ala Leu Leu Lys Lys Giu Arg Ile 100 105 110 Pro His Thr Val Leu Asn Ala Lys Gin His Thr Lys Giu Ala Glu Ile 115 120 125 Ile Lys Asp Al1a Giy Leu Lys Gly Ala Val Thr Ile Ala Thr Asn Met 130 135 140 614 Ala Gly Arg Gly Val Asp Ile Lys Leu Thr Asp Glu Val Lys Glu Leu 145 150 155 160 Gly Gly Leu Tyr Ile Ile Gly Thr Glu Arg His Glu Ser Arg Arg Ile 165 170 175 Asp Asn Gin Leu Arg Gly Arg Ser Gly Arg Gin Gly Asp Pro Gly Val 180 185 190 Ser Gin Phe Tyr Leu Ser 195 INFORMATION FOR SEQ ID N0:737: SEQUENCE CHARACTERISTICS: LENGTH: 208 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...208 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:737 SVal Val Ala Asp Glu Val Arg Lys Leu Ala Glu Lys Thr Gin Lys Ala 1 5 10 Thr Lys Glu Ile Ala Val Val Val Lys Ser Met Gin Gin Glu Ala Asn 25 Asp Ile Gin Thr Asn Thr His Asp Ile Asn Ser Ile Val Gly Ser Ile 35 40 Lys Gly Asp Val Glu Glu Leu Lys Ser Thr Val Lys Asn Asn Met Ile 55 Val Ala Gin Ala Ala Lys Tyr Thr Ile Tyr Asn Ile Asn Asn Arg Val 70 75 Phe Cys Gly Unk Ala Lys Leu Asp His Val Val Phe Lys Asn Asn Leu 90 Tyr Gly Met Val Unk Leu Val Ser Ile Pro Leu Thr Leu Pro Ala His 100 105 110 Lys Ser Unk Arg Leu Gly Lys Trp Tyr Tyr Glu Gly Ala Gly Lys Glu o* 115 120 125 Asn Phe Ala Asn Thr Ser Gly Tyr Arg Ala Leu Glu Ser His His Ala 130 135 140 Ser Val His Ala Glu Ala Asn Asp Leu Val Lys Ala Val Gin Glu Asp 145 150 155 160 His Val Thr Asp Ser Lys Tyr Leu Glu His Lys Val His Leu Met Glu 165 170 175 Asp Ser Ala Lys His Val Lys Glu Asn Ile Asp Lys Met Phe Tyr Glu 180 185 190 Lys Gin Asp Glu Leu Asn Lys Ile Ile Glu Lys Ile Gin Lys Gly Glu 195 200 205 INFORMATION FOR SEQ ID NO:738: SEQUENCE CHARACTERISTICS: LENGTH: 201 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...201 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:738 Met Asn Thr Ser Lys Lys Leu Gly Asn Pro Leu Leu Phe Leu His Asp 1 5 10 Asn Lys Ile Leu Leu Phe Val Val Gly Val Ser Met Gly Gly Trp Ala 25 Thr Ser Lys Ile Tyr Gin Phe Glu Ser Ala Leu Glu Pro Ile His Phe 40 Lys Phe Ala Arg Lys Leu Ser Leu Ser Pro Phe Leu Asn Leu Ser His 55 Leu Val Arg Asn Lys Pro Leu Asn Thr Thr Asp Gly Gly Phe Met Leu 70 75 Pro Leu Tyr His Glu Leu Ala Thr Gin Tyr Pro Leu Leu Leu Lys Phe 90 Asp Gin Gin Asn Asn Pro Arg Glu Leu Leu Arg Pro Asn Thr Leu Asn 100 105 110 His Gin Leu Gin Pro Ser Leu Thr Pro Phe Lys Asp Cys Ala Val Met 115 120 125 Ala Phe Arg Asn His Ser Phe Lys Asp Ser Leu Met Leu Glu Thr Cys 130 135 140 Lys Thr Pro Thr Asp Trp Gin Lys Pro Ile Ser Thr Asn Leu Lys Asn 145 150 155 160 S.Leu Asp Asp Ser Leu Asn Leu Leu Asn Leu Asn Gly Ile Leu Tyr Leu S165 170 175 Ile His Asn Pro Ser Asp Leu Ser Leu Arg Arg Lys Glu Leu Trp Leu 180 185 190 Ser Lys Leu Glu Asn Gin Gin Leu Ile 195 200 INFORMATION FOR SEQ ID NO:739: SEQUENCE CHARACTERISTICS: LENGTH: 127 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...127 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:739 Met Ser Ile Gin His Phe Arg Val Ala Leu Ile Pro Phe Phe Ala Ala 1 5 10 Phe Cys Leu Pro Val Phe Ala His Pro Glu Thr Leu Val Lys Val Lys 25 616 Asp Ala Glu Asp Gin Leu Gly Ala Arg Val Gly Tyr Ile Glu Leu Asp 40 Leu Asn Ser Gly Lys Ile Leu Glu Ser Phe Arg Pro Glu Glu Arg Phe 55 Pro Met Met Ser Thr Phe Lys Val Leu Leu Cys Gly Ala Val Leu Ser 70 75 Arg Ile Asp Ala Gly Gin Glu Gin Leu Gly Arg Arg Ile His Tyr Ser 90 Gin Asn Asp Leu Val Glu Tyr Ser Pro Val Thr Glu Lys His Leu Thr 100 105 110 Asp Gly Met Thr Val Arg Glu Leu Ser Arg Trp Cys His Asn His 115 120 125 INFORMATION FOR SEQ ID NO:740: SEQUENCE CHARACTERISTICS: LENGTH: 79 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori 9* (ix) FEATURE: o NAME/KEY: misc_feature LOCATION 1...79 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:740 Val Asn Val Gly Val Pro Phe Ser Tyr Gin Val Ser Ala Thr Phe Gin 1 5 10 Asn Ser Arg Leu Ser Ser Leu Leu Glu Thr Leu Lys Lys Ser Phe Leu 25 SGlu Lys Pro Leu Ile Glu Ser Ser Ala Asn Lys 'Ile Ala Asp Ile Phe 40 S Ser Lys Ala Val Leu Phe Leu Ala Phe Val Ser Phe Leu Leu Trp Gin 55 Phe Gly Leu Gly Gly Asn Phe Glu Lys Ser Phe Asn Gly Val Tyr 65 70 INFORMATION FOR SEQ ID NO:741: SEQUENCE CHARACTERISTICS: LENGTH: 49 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...49 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:741 Met Leu Met Val Asn Gly Tyr Gin Ile Thr Met His Lys Gly Tyr LYS 1 5 10 Val Gly Phe Phe Thr Ser Gly TIyr Asn Pro Asp Phe Ala Gin Thr Ile 25 Gin Asn Arg Ser Tyr Leu Met Ser Ser Tyr Glu Leu Ser Phe Leu Arg 40 Asn INFORMATION FOR SEQ ID NO:742: SEQUENCE CHARACTERISTICS: LENGTH: 412 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1..-412 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:742 5909Met Val Gin Phe Gin Asn Thr Leu Ile Lys Phe His Ala Leu Ser Phe s. 1 5 10 :*fee* Lys Asn Ala Asn Leu Ile Tyr Asn Ala Lys Leu Asn Lys Thr Cys Tyr 25 *Lys Giu Asn Sen Asn Thr Ile Ile Leu Arg Ile Lys Met Leu Thr Gin 40 Giu Asp Val Leu Asn Ala Leu Lys Thr Ile Ile Tyr Pro Asn Phe Giu 55 6 9j Lys Asp Ile Val Sen Phe Gly Phe Val Lys Asn Ile Thr Leu His Asp 70 75 Asn Gin Leu Giy Leu Leu I1e-Giu Ile Pro Ser Ser Sen Giu Glu Thr 90 Ser Ala Ile Leu Arg Giu Asn Ile Ser Lys Ala Met Gin Giu Lys Gly *100 105 *Val Lys Ala Leu Asn Leu Asp Ile Lys Thr Pro Pro Lys Pro Gin Ala 115 120 125 Pro Lys Pro Thn Thr Lys Asn Leu Ala Lys Asn Ile Lys His Val Val :*:130 135 140 Met Ile Ser Sen Gly Lys Gly Gly Val Gly Lys Ser Thr Thr Ser Val 145 150 155 160 Asn Leu Ser Ile Aia Leu Ala Asn Leu Asn Gin Lys Val Gly Leu Leu 165 170 175 Asp Ala Asp Val Tyr Gly Pro Asn Ile Pro Arg Met Met Gly Leu Gin 180 185 190 Asn Ala Asp Val Ile Met Asp Pro Ser Gly Lys Lys Leu Ile Pro Leu 195 200 205 Lys Ala Phe Gly Val Ser Val Met Sen Met Gly Leu Leu Tyr Asp Giu 210 215 220 Gly Gin Ser Leu Ile Tnp, Ang Gly Pro Met Leu Met Arg Ala Ile Giu 225 230 235 240 Gin Met Leu Ser Asp Ile Ile Trp Gly Asp Leu Asp Val Leu Val Vai 245 250 255 Asp Met Pro Pro Arg Asn Ang Arg Cys Ala Ala His Ala Ala Gin Ala 260 265 270 618 Val Pro Leu Ser Ala Gly Ile Thr Val Thr Thr Pro Gin Ile Val Ser 275 280 285 Leu Asp Asp Ala Lys Arg Ser Leu Asp Met Phe Lys Lys Leu His Ile 290 295 300 Pro Ile Ala Gly Ile Val Glu Asn Met Gly Ser Phe Val Cys Glu His 305 310 315 320 Cys Lys Lys Glu Ser Glu Ile Phe Gly Ser Asn Ser Met Ser Gly Leu 325 330 335 Leu Glu Ala Tyr Asn Thr Gin Ile Leu Ala Lys Leu Pro Leu Glu Pro 340 345 350 Lys Val Arg Leu Gly Gly Asp Lys Gly Glu Pro Ile Val Ile Ser His 355 360 365 Pro Thr Ser Val Ser Ala Lys Ile Phe Glu Lys Met Ala Lys Asp Leu 370 375 380 Ser Ala Phe Leu Asp Lys Val Glu Arg Glu Lys Leu Ala Asp Asn Lys 385 390 395 400 Asp Ile Gin Pro Thr Gin Thr His Ala Tyr Ser His 405 410 INFORMATION FOR SEQ ID NO:743: SEQUENCE CHARACTERISTICS: LENGTH: 89 amino acids TYPE: amino acid TOPOLOGY: linear .o (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...89 (xi) SEQUENCE DESCRIPTION: SEQ ID N0:743 Met Gly Val Val Ile Gly Glu Thr Thr Glu Ile Gly Asp Asp Val Thr 1 5 10 Ile Tyr His Gly Val Thr Leu Gly Gly Thr Gly Lys Phe Lys Gly Lys 25 Arg His Pro Thr Leu Gly Asn Arg Val Val Val Gly Ala Gly Ala Lys 40 Val Leu Gly Ala Ile Cys Val Gly Asp Asp Val Arg Ile Gly Ala Asn S* 50 55 Ala Val Val Leu Ser Asp Leu Pro Thr Gly Ser Thr Ala Val Gly Ala 70 75 Lys Ala Lys Thr Ile Thr Lys Asp Arg INFORMATION FOR SEQ ID NO:744: SEQUENCE CHARACTERISTICS: LENGTH: 192 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...192 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:744 Met Leu Ser Phe Ile Ser Ala Phe Asp Lys Arg Gly Val Ser Ile Arg 1 5 10 Leu Leu Thr Ala Leu Leu Leu Leu Phe Ser Leu Gly Leu Ala Lys Asp 25 Leu Glu Ile Gin Thr Phe Val Ala Lys Tyr Leu Ser Lys Asn Gin Lys 40 Ile Gin Ala Leu Gin Glu Gin Ile Asp Ala Leu Asp Ser Gin Glu Lys 55 Val Val Ser Lys Trp Asp Asn Pro Ile Leu Tyr Leu Gly Tyr Asn Asn 70 75 Ala Asn Val Ser Asp Phe Phe Arg Leu Asp Ser Thr Leu Met Gin Asn 90 Met Ser Leu Gly Leu Ser Gin Lys Val Asp Leu Asn Gly Lys Lys Leu 100 105 110 Thr Gin Ser Lys Met Ile Asn Leu Glu Lys Gin Lys Lys Ile Leu Glu 115 120 125 Leu Lys Lys Thr Lys Gin Gin Leu Val Ile Asn Leu Met Ile Asn Gly 130 135 140 Ile Glu Asn Tyr Lys Asn Gin Gin Glu Ile Glu Leu Leu Asn Thr Ala 145 150 155 160 Ile Lys Asn Leu Glu Asn Thr Leu Tyr Gin Ala Asn His Ser Ser Ser 165 170 175 Pro Asp Leu Ile Glu Ile Asp Lys Leu Glu Asn Leu Lys Ile Ala Asn 180 185 190 INFORMATION FOR SEQ ID NO:745: SEQUENCE CHARACTERISTICS: LENGTH: 109 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein S(iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...109 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:745 Val Unk Leu Tyr Leu Ala Leu Thr Leu Ser Leu Gly Ile Ala Met Leu 1 5 10 Leu Val Glu Met Leu Ile Gly Asn Leu Gly Lys Lys Asp Val Val Ser 25 Asn Tyr Gin Ile Leu Asp Pro Lys Arg Lys Lys Tyr Tyr Pro Phe Thr 40 Ser Phe Phe Ile Leu Gly Gly Pro Leu Ile Leu Ser Phe Tyr Ala Val 55 Val Leu Gly Trp Val Leu Tyr Tyr Leu Phe Val Val Thr Phe Asp Leu .70 75 620 Pro Lys Asp Leu Unk Gin Ala Lys Met Gin Phe Unk Met Leu Gin Asn 90 Gly Ser Leu Ile Trp Pro Val Ile Asp Phe Ser Ala Cys 100 105 INFORMATION FOR SEQ ID NO:745: SEQUENCE CHARACTERISTICS: LENGTH: 109 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...109 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:745 Val Unk Leu Tyr Leu Ala Leu Thr Leu Ser Leu Gly Ile Ala Met Leu 1 5 10 Leu Val Glu Met Leu Ile Gly Asn Leu Gly Lys Lys Asp Val Val Ser 20 25 Asn Tyr Gin Ile Leu Asp Pro Lys Arg Lys Lys Tyr Tyr Pro Phe Thr 35 40 Ser Phe Phe Ile Leu Gly Gly Pro Leu Ile Leu Ser Phe Tyr Ala Val 50 55 Val Leu Gly Trp Val Leu Tyr Tyr Leu Phe Val Val Thr Phe Asp Leu 70 75 Pro Lys Asp Leu Unk Gin Ala Lys Met Gin Phe Unk Met Leu Gin Asn 85 90 Gly Ser Leu Ile Trp Pro Val Ile Asp Phe Ser' Ala Cys 100 105 INFORMATION FOR SEQ ID NO:746: SEQUENCE CHARACTERISTICS: LENGTH: 116 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...116 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:746 Val Pro Ala Val Gly Gly Ala Leu Ile Trp Unk Unk Ile Unk Ile Tyr 1 5 10 Glu Leu Tyr His Gly Unk Val Asn Glu Unk Ile Phe Unk Val Leu Tyr
I
Leu Ile dly Val Leu Phe Ile Lys Lys Arg Leu Ile Phe Phe Ser Giy Ile Ile Vai Gly Arg Leu Tyr Giu Asn 100 Cys 25 Ile Asp Ser Ile Phe Lys Met Ile Aia 75 Pro Thr Ile 90 Tyr Phe Ile 105 Lys Pro Ile Leu Lys Ile Ser Gin Phe Phe Phe Ile Giu Gin Lys 110 INFORMATION FOR SEQ ID NO:747: SEQUENCE CHARACTERISTICS: LENGTH: i63 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION l. 163 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:747 Val Val Vai Ile Ile Leu Val Val Val Ile Ile
S.
S
55..
S. 55
S
S *5*5 *5 S .5.S a *5S5 5* S S
S
1 Leu Asn Pro Lys Arg Phe Arg His Glu 145 Leu Arg Asn Leu Lys Val Phe Arg Asp Giy Gin Thr Giu Asn Vali Lys dly Asn 135 Arg Pro His Asn Asp Tyr 105 Gly Ser Ile Giu Giu Ile Asp Leu Leu Thr Thr Leu Ile Asn Giu Ala Gin Tyr Lys 155 INFORMATION FOR SEQ ID NO:748: SEQUENCE CHARACTERISTICS: LENGTH: 40 amino acids TYPE: amino acid TOPOLOGY: linear 622 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...40 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:748 Met Asp Glu Ile Tyr Gin Ile Ala Lys Asn Lys Thr Leu Ile Val Ile 1 5 10 Ala His Arg Leu Ser Thr Ile Glu Arg Cys Glu Val Ile Ile Asp Met 25 Ser Gin His Lys Asp Asn Leu Gly INFORMATION FOR SEQ ID NO:749: SEQUENCE CHARACTERISTICS: LENGTH: 45 amino acids oo*. TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...45 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:749 *ee.
Val Ala Gly Ser Phe Ile Ile Ala Leu Phe Ser Val Leu Ala Asp Gin 1 5 10 Phe Val Ser Val Phe Gin His Glu Asn Ala Leu Gin Arg Leu Phe Ser 25 Gin Asn Ala Thr Gin Lys Gin Lys Lys Lys Ser Leu Cys 40 INFORMATION FOR SEQ ID NO:750: SEQUENCE CHARACTERISTICS: LENGTH: 118 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...118 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:750 Met Val Ala Leu Ser Asn Ala Leu Ser Arg Val Phe Gly Ser Val Ala 1 5 10 Gly Tyr Lys Phe Pro Ser Phe Ile Gin Lys Ser Ile Asn Ala Leu Tyr 25 Val Lys Ile Phe Lys Ile Asp Leu Ser Glu Phe Glu Pro Leu Glu Asn 40 Tyr Lys Ser Leu Asn Ala Leu Phe Met Arg Ser Leu Lys Lys Glu Arg 55 Pro Phe Asp Lys Ala Pro Ile Phe Ala Leu Arg Leu Ala Met Ala Leu 70 75 lie Thr Glu Cys Ala Phe Leu Asp Asn Asp Ser Ala Leu Gin Ile Lys 90 Gly Met Pro Tyr Lys Ala His Glu Leu Val Gly Glu Ile Asn Pro Leu 100 105 110 Ser Pro Leu Phe Ser Met 115 INFORMATION FOR SEQ ID NO:751: SEQUENCE CHARACTERISTICS: LENGTH: 200 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES S* (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...200 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:751 Met Ala Val Leu Lys Lys Met Ile Gly Leu Val Ala Val Leu Ser Val 1 5 10 Leu Leu Ala Arg Asp Asn Pro Phe Glu Pro Glu Ile Asn Ser Lys Asn 25 Leu Gln Gly Gly Phe Ser Gly Ile Tyr Asp Asp Tyr Leu Lys Glu Ile 40 His Val Asp Leu Pro Thr Ser Ala Arg Ile Leu Lys Lys Ile Thr Leu 55 Thr Tyr Gin Asp Ile Asp Gly Ser Ile His Ser Lys Val Val Gly Ile 70 75 Asp Lys Ser Ile Asp Trp His Tyr Pro Leu Lys Leu Ser Gin His Thr 90 Leu Asn Gin Asp Ala Phe Glu Lys Arg Tyr Gin Ile Gin Asp Phe Asp 100 105 110 Phe Leu Met Ala Asn Asn Thr Met Ile Leu Arg Ser Pro Tyr Lys Ile 115 120 125 Leu Arg Ser Phe Val Leu Val Asn Pro Tyr Arg Ile Val Leu Asp Thr 130 135 140 Gin Lys Gly Pro Leu Asp Ile Tyr Gin Asn Met Asp Leu Asn Gln Lys 145 150 155 160 Phe Phe Ser His Ile Lys Val Gly Thr His Lys Asp Tyr Tyr Arg Ile 165 170 175 624 Thr Leu Ile Leu Asp Gly Lys Tyr Arg Tyr Leu Leu Glu Glu Lys Asn 180 185 190 Gly Ala Tyr Glu Leu Lys Leu Lys 195 200 INFORMATION FOR SEQ ID NO:752: SEQUENCE CHARACTERISTICS: LENGTH: 79 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...79 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:752 S Met Gly Gly Phe Thr Ser Ile Trp His Trp Val Ile Val Leu Leu Val 1 5 10 Ile Val Leu Leu Phe Gly Ala Lys Lys Ile Pro Glu Leu Ala Lys Gly 20 25 Leu Gly Ser Gly Ile Lys Asn Phe Lys Lys Ala Val Lys Asp Asp Glu 35 40 SGlu Glu Ala Lys Asn Glu Leu Lys Thr Leu Asp Ala Gln Ala Thr Gin 50 55 Thr Lys Val His Glu Thr Ser Glu Ile Lys Ser Lys Gin Glu Ser 70 INFORMATION FOR SEQ ID NO:753: SEQUENCE CHARACTERISTICS: LENGTH: 97 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...97 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:753 Leu Thr Thr Lys Ala Cys Trp Leu Leu Arg Val Cys Cys Tyr Arg Ser 1 5 10 Leu Asn Ile Thr Ile Lys Asp Arg Thr Met Lys Thr Asn Gly His Phe 25 Lys Asp Phe Ala Trp Lys Lys Cys Phe Leu Gly Ala Ser Val Val Ala 40 Leu Leu Val Gly Cys Ser Pro His Ile Ile Glu Thr Asn Glu Val Ala 625 55 Leu Lys Leu Asn Tyr His Pro Ala Ser Glu Lys Val Gin Ala Leu Asp 70 75 Glu Lys Ile Leu Leu Leu Arg Pro Ala Phe Gin Tyr Ser Unk Asn Ile 90 Cys INFORMATION FOR SEQ ID NO:753: SEQUENCE CHARACTERISTICS: LENGTH: 97 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...97 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:753 Leu Thr Thr Lys Ala Cys Trp Leu Leu Arg Val Cys Cys Tyr Arg Ser 1 5 10 Leu Asn Ile Thr Ile Lys Asp Arg Thr Met Lys Thr Asn Gly His Phe 20 25 Lys Asp Phe Ala Trp Lys Lys Cys Phe Leu Gly Ala Ser Val Val Ala 35 40 Leu Leu Val Gly Cys Ser Pro His Ile Ile Glu Thr Asn Glu Val Ala 55 Leu Lys Leu Asn Tyr His Pro Ala Ser Glu Lys Val Gin Ala Leu Asp 65 70 75 Glu Lys Ile Leu Leu Leu Arg Pro Ala Phe Gln'Tyr Ser Unk Asn Ile 90 Cys INFORMATION FOR SEQ ID NO:754: SEQUENCE CHARACTERISTICS: LENGTH: 145 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...145 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:754 626 Leu Ser Giu Trp Gin Thr Phe Cys Leu Lys Asp Leu Gly Lys Ile Val 1 5 10 Giy Giy Ala Thr Pro Pro Thr Asn Asn Pro Lys Asn Tyr Gly Asn Lys 25 Ile Ala Trp Ile Thr Pro Lys Asp Leu Ser Thr Leu Gin Gly Arg Tyr 40 Ile Lys Lys Gly Ser Arg Ser Ile Ser Arg Leu Gly Phe Lys Ser Cys 55 Ser Cys Val Leu Leu Pro Lys His Ala Ile Leu Phe Ser Ser Arg Ala 70 75 Pro Ile Gly Tyr Val Ala Ile Ala Glu Lys Arg Leu Cys Thr Asn Gin 90 Gly Phe Lys Ser Ile Ile Pro Asn *Lys Lys Ile Tyr Phe Giu Phe Leu 100 105 110 Tyr Tyr Leu Leu Lys Tyr Tyr Lys Asp Asn Ile Ser Asn Ile Gly Gly 115 120 125 Gly Thr Thr Phe Lys Glu Val Ser Giy Ala Thr Leu Gly Ser Ile Pro 130 135 140 Ser 145 INFORMATION FOR SEQ ID NO:754: SEQUENCE CHARACTERISTICS: LENGTH: 145 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE- NAME/KEY: misc-feature LOCATION .145 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:754 *Leu Ser Glu Trp, Gin Thr Phe Cys Leu Lys Asp Leu Gly Lys Ile Val 1 5 10 Gly Gly Ala Thr Pro Pro Thn Asn Asn Pro Lys Asn Tyr Gly Asn Lys 25 Ile Ala Trp Ile Thr Pro Lys Asp Leu Sen Thr Leu Gin Gly Ang Tyr 40 Ile Lys Lys Gly Ser Arg Ser Ile Ser Ang Leu Gly Phe Lys Sen Cys 55 Sen Cys Val Leu Leu Pro Lys His Ala Ile Leu Phe Sen Ser Ang Ala 70 75 Pro Ile Gly Tyr Val Ala le Ala Giu Lys Ang Leu Cys Thr Asn Gin 90 Gly Phe Lys Sen Ile Ile Pro Asn Lys Lys Ile Tyr Phe Giu Phe Leu 100 105 110 Tyr Tyr Leu Leu Lys Tyn Tyr Lys Asp Asn Ile Sen Asn Ile Gly Gly 115 120 125 Gly Thr Th~r Phe Lys Giu Val Sen Giy Ala Thr Leu Gly Ser Ile Pro 130 135 140 Sen 145 INFORMATION FOR. ,SEQ ID NO:755: SEQUENCE CHARACTERISTICS: LENGTH: 206 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .206 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:755 Val Arg Leu Asn Ala Ala Val Val Val Asp Gly Lys Tyr Lys Ile Ala 1 5 10 Leu Glu Asp Gly Ala Asn Ala Leu Giu Tyr Giu Pro Leu Ser Asp Giu 25 Unk Unk Lys Lys Ile Asn Unk Leu Val Lys Gin Ala Ile Giy Asp Asn 40 Gin Asn Arg Gly Asp Asp Val Ala Val Ser Asn Phe Giu Phe Asn Pro 55 Met Val Pro Met Ile Asp Asn Ala Thr Leu Ser Giu Lys Ile Ile Tyr 65 70 75 Lys Thr Gin Lys Ile Leu Gly Leu Phe Met Phe Leu Ile Lys Val Tyr 90 Leu Val Phe Ile Val Leu Phe Ile Phe Tyr Lys Lys Val Ile Val Pro *10,0 105 110 Phe Ser Glu Arg Met Leu Glu Val Val Pro Asp Giu Asp Lys Giu Val *115 120 125 Lys Sen Met Phe Giu Giu Met Asn Giu Giu Giu Asp Giu Leu Asn Lys *Lu130 135 140 LuGly Asp Leu Arg Lys Lys Val Giu Asp Gin Leu Gly Leu Asn Ala 145 150 155 160 Ser Phe Ser Glu Glu Giu Val Arg Tyr Gu Ile -Ile Leu Glu Lys Ile 165 170 175 .Arg Gly Thr Leu Lys Giu Arg Pro Asp Giu Ile Ala Thr Leu Phe Lys 180 185 190 Leu Leu Ile Lys Asp Glu Ile Sen Sen Asp Ser Ala Lys Gly 195 200 205 INFORMATION FOR SEQ ID NO:756: Wi SEQUENCE CHARACTERISTICS: LENGTH: 98 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: (A).NAME/KEY: misc_feature (B)LOCATION .98 628 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:756 Val Cys Phe Ile Leu Pro Phe Cys Leu Gly Val Leu Gly Thr Gin Ile 1 10 Phe Lys Gin Giu Thr Pro Arg Gin Leu Pro Ile Val Val Val Asp Leu 25 Asp Lys Thr Thr Thr Ser His Gin Val Ala Phe Giu Leu Giy Aia Thr 40 Ser Ala Val Giu Ile Lys Tvr Gin Vai Thr Ser Leu Ser Giu Aia Lys 55 Arg Phe Leu Asn Ser Ala Giu Val Tyr Gly Ala Leu Ile Leu Pro Lys 70 75 Asp Leu Glu Ar g Lys Ile Lys Met Gly Arg Lys Val Unk Phe Ala Leu 90 Leu Leu INFORMATION FOR SEQ ID NO:757: SEQUENCE CHARACTERISTICS: LENGTH: 197 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .197 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:757 Met Lys Gly Leu Tnp Leu Vai Ile Sen Leu Vali Phe Val Giy Phe Leu 1 5 10 Trp Ala Asn Glu, Ser Tyr Val Phe Asn Asn Sen Lys Gly Arg Leu Thn Glu Lys Sen Vai Ala Phe Ile Glu Gly Val Sen Lys Giu Leu Tyr Leu 40 Lys Thr Gly Val Arg Phe Ala Ile Asp Met Thr Asp Phe Giu Lys Asn s0 55 Pro Ile Ala Leu Ala Asn Lys Lys Glu Arg Gin Sen Tyr Gin Glu Gly 70 75 Phe Leu Lys Gin Leu Lys Pro Pro Phe Val Val Phe Phe Phe Tyr His 90 Asp Ala Gin Lys Ile Glu Leu Val Ala Asn Pro Lys Asp Leu Leu Asp 100 105 110 Thr Asp Lys Ile Phe Phe Glu Lys Ile Ala Pro Leu Leu Pro Thr Asn 115 120 125 Ala Lys Glu Tyr Tbr Pro Gin Arg Ile Ser Ala Met Leu Ile Asn Gly 130 135 140 Tyr Ser Val Ala Val Asp Ala Leu Ala Giu Lys Tyr His Val Asn Ile 145 150 155 160 Thr Gin Asn Phe Sen Ala Pro Lys Giy Val Thr Phe Val Lys Val Val 165 170 175 Ile Tyr Ile Leu Leu Leu Thr Leu Leu Gly Ala Phe Leu Gly Leu Tyr 180 185 190 Phe Phe Lys Lys Ser 195 INFORMATION FOR SEQ ID NO:758: SEQUENCE CHARACTERISTICS: LENGTH: 148 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...148 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:758 Leu Val Gin Ile Val Val Val Phe Tyr Gly Leu Pro Ala Leu Gly Val 1 5 10 Tyr Met Asp Pro Ile Pro Ala Gly Ile Ile Ala Phe Ser Phe Asn Val 25 Gly Ala Tyr Ala Ser Glu Thr Leu Arg Ala Ser Phe Leu Ser Val Pro 35 40 Lys Asp Gin Trp Asp Ser Ser Leu Ser Leu Gly Leu Asn Tyr Leu Gin 50 55 Thr Phe Trp His Val Ile Phe Phe Gin Ala Leu Lys Val Ala Thr Pro 65 70 75 Ser Leu Ser Asn Thr Phe Ile Ser Leu Phe Lys Glu Thr Ser Leu Ala 85 90 Ser Val Val Thr Ile Ala Glu Unk Phe Arg Ile Ala Gin Gin Lys Unk 100 105 110 Asn Val Ser Tyr Asp Phe Unk Pro Ile Tyr Leu Glu Unk Ala Leu Ile 115 120 125 Tyr Trp Leu Phe Cys Leu Val Leu Glu Val Ile Gin Lys Arg Val Glu 130 135 140 Lys Ile Leu Asn 145 ,9 INFORMATION FOR SEQ ID NO:758: SEQUENCE CHARACTERISTICS: LENGTH: 148 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...148 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:758 Leu Val Gin Ile Val Val Val Phe Tyr Gly Leu Pro Ala Leu Gly Val 1 5 10 I 630 Tyr Met Asp Pro Ile Pro Ala ly Ile Ile Ala Phe Ser Phe Asn Val 25 Gly Ala Tyr Ala Ser Giu Thr Leu Arg Ala Sez Phe Leu Ser Val Pro 40 Lys Asp Gin Trp Asp Ser Ser Leu Ser Leu Gly Leu Asn Tyr Leu Gln 55 Thr Phe Trp His Val Ile Phe Phe Gin Ala Leu Lys Val Ala Thr Pro 6S 70 75 Ser Leu Ser Asn Thr Phe Ile Ser Leu Phe Lys Glu Thr Ser Leu Ala 90 Ser Val Val Thr Ile Ala Glu Unk Phe Arg Ile Ala Gin Gin Lys Unk 100 105 110 Asn Val Ser Tyr Asp Phe Unk Pro Ile Tyr Leu Glu Unk Ala Leu Ile 115 120 125 Tyr Trp, Leu Phe Cys Leu Val Leu Glu Val Ile Gin Lys Arg Vai Glu 130 135 140 Lys Ile Leu Asn 145 INFORMATION FOR SEQ ID NO:759: SEQUENCE CHARACTERISTICS: LENGTH: 68 amino acids TYPE: amino acid TOPOLOGY: linear s**9 (ii) MOLECULE TYPE: protein *(iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .68 SEQUENCE DESCRIPTION: SEQ ID NO:759 Met Cys Ser Lys Lys Ile Arg Asn Leu Ile Leu Cys Phe Gly Phe Ile 1 5 10 Leu Ser Leu Cys Ala Glu Giu Asn Ile Thr Lys Glu Asn Met Thr Glu 09020 25 *0004* Thr Asn Thr Thr Glu Giu Asn Thr Pro Lys Asp Ala Pro Ile Leu Leu 40 Glu Glu Lys Arg Ala Gin Thr Leu Glu Leu Lys Glu Glu Asn Glu Val .9.50 55 0 Ala Lys Lys Ile INFORMATION FOR SEQ ID NO:760: SEQUENCE CHARACTERISTICS: WA LENGTH: 134 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...134 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:760 Val Val Ala Asp Glu Val Arg Asn Leu Ala Gly Arg Thr Gin Lys Set 1 5 10 Leu Ala Glu Ile Asn Ser Thr Ile Met Val Ile Val Gin Glu Ile Asn 25 Asp Val Ser Ser Gin Met Asn Leu Asn Ser Gin Lys Met Glu Arg Leu 40 Ser Asp Met Ser Lys Ser Val Gin Glu Thr Tyr Glu Lys Met Ser Ser 55 Asn Leu Ser Ser Val Val Leu Asp Ser Asn Gin Ser Met Asp Asp Tyr 70 75 Ala Lys Ser Gly His Gin Ile Glu Ala Met Val Ser Asp Phe Ala Glu 90 Val Glu Lys Val Ala Ser Lys Thr Leu Ala Asp Ser Ser Asp Ile Leu 100 105 110 Asn Ile Ala Thr His Val Ser Gly Thr Thr Met Asn Leu Unk Lys Gin 115 120 125 Val Asn Leu Phe Lys Thr 130 INFORMATION FOR SEQ ID NO:760: oee SEQUENCE CHARACTERISTICS: 06:4 LENGTH: 134 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori.
(ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...134 goo$ (xi) SEQUENCE DESCRIPTION: SEQ ID NO:760 SVal Val Ala Asp Glu Val Arg Asn Leu Ala Gly Arg Thr Gin Lys Ser 1 5 10 Leu Ala Glu Ile Asn Ser Thr Ile Met Val Ile Val Gin Glu Ile Asn 25 Asp Val Ser Ser Gin Met Asn Leu Asn Ser Gin Lys Met Glu Arg Leu 40 Ser Asp Met Ser Lys Ser Val Gin Glu Thr Tyr Glu Lys Met Ser Ser 55 Asn Leu Ser Ser Val Val Leu Asp Ser Asn Gin Ser Met Asp Asp Tyr 70 75 Ala Lys Ser Gly His Gin Ile Glu Ala Met Val Ser Asp Phe Ala Glu 90 Val Glu Lys Val Ala Ser Lys Thr Leu Ala Asp Ser Ser Asp Ile Leu 100 105 110 Asn Ile Ala Thr His Val Ser Gly Thr Thr Met Asn Leu Unk Lys Gin 115 120 125 Val Asn Leu Phe Lys Thr 130 INFORMATION FOR SEQ ID NO:761: SEQUENCE CHARACTERISTICS: LENGTH: 93 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...93 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:761 Val Leu Lys Thr Leu Ser Ile Arg Leu Val Ile Leu 1 5 10 Leu Ala Thr Asn Ala Cys Ser Gly Val Gln Lys Leu 25 His Arg Tyr Ala Ile Asn Phe His Arg Ser Thr Lys 35 40 Lys Gln Ile Ala Leu Leu Lys Glu Lys Gly Ile Gly 50 55 Lys Lys Leu Leu Asp Tyr Phe Gly Ser Phe Glu Ala 65 70 75 Ser Asp Gln Glu Lys Asn Ala Val Leu Lys Lys Arg 9 Leu Asn Cys Arg Asp Glu Leu Lys Asn Glu Ala Ser Ile Glu Lys Lys Ser Ser Met Val Ala INFORMATION FOR SEQ ID NO:762: SEQUENCE CHARACTERISTICS: LENGTH: 73 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...73 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:762 Val Gly Ile Ile Arg Gly Ile Ile His Arg Pro Glu Leu Ile Leu Leu 1 5 10 Asp Glu Pro Phe Ser Ala Leu Asp Ser Leu Asn Arg Lys Asn Leu Gln 25 Asp Leu Ile Lys Glu Ile His Gln Asn Ser Cys Ala Thr Phe Ile Met 40 Val Thr His Asp Glu Asn Glu Ala Gln Lys Leu Ala Thr Lys Thr Leu 55 Glu Ile Lys Ala Leu Lys Gln Glu Gln INFORMATION FOR SEQ ID NO:763: SEQUENCE CHARACTERISTICS: LENGTH: 268 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 2...268 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:763
S
Val Leu Glu Lys Lys 65 Arg Giu Asp Asp Arg 145 Ile Ile Ser Val Ser 225 Unk Lys I le Arg Lys His 50 Leu Ang Asp Lys Phe 130 Met Val.
Giu Leu Lys 210 G lu Msn Thr Asp G lu 35 Ala Ile Gin Asn Lys 115 Cys Val1 Msn Ala Giy 195 Val Thr Ala Ala Arg 20 Giu Leu Ile Ile Pro 100 Gly Val2 Phe C ly Val 180 Asp Leu Asp Tyr Arg 260 Met Ile Lys Giu Ala His Gly Sen Giu Leu 165 Lys Val Leu Ala Asp 245 Ala Giu Ala Pro Lys 70 Thr Lys Asn Ile Ile 150 Ala Ile Met Asp Giu 230 Leu Leu Phe Lys Sen 55 Tyr Ile Lys Glu Thr 135 Unk Trp, Arg Lys Asn 215 Asn His Gly Ile Asn 40 Giu Thr Met Gly Giu 120 Pro Pro Thn Gly Giu 200 Giu Unk Leu Ser Ser 25 Val1 Arg Arg Arg 105 Asn Asp Ile Pro Lys 185 Ser Thr Lys His Leu 265 Val2 Leu Asp Giu Lys 90 Thr Giu Asn Asp Val1 170 dly Ala Leu
LYS
Val 250 Trp Sen Ile Ile Aia 75 Ala Lys Lys Leu C iu 155 Gly Glu Ile Lys Lys 235 Pro Arg Ser Pro Ser Gly Ala Lys Arg Lys 140 Glu Gly Leu Ile Val 220 Lys Lys Ala Tyr Gin His Val1 Leu Ser Giy 125 Glu Asn Asp Lys Ala 205 Pro Val Gly Thr Giu Giu Ang Lys Giu 110 Glu Tyr Lys Val1 Leu 190 Phe Lys Leu Leu Pro Leu Cys Asp Tyr Asp Sen Leu Ile Leu 175 Thr Sen Ile Lys Ang 255 Ser Giu Leu Leu Leu Lys Lys Giu Giy 160 Lys Gly Val1 Pro Val1 240 Leu Phe Ile Ala Thr Ala Asn Asn Ile Asp Arg Ile Pro Ala Pro INFORMATION FOR SEQ ID NO:764; SEQUENCE CHARACTERISTICS: LENGTH: 273 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE.
NAME/KEY: misc-feature LOCATION .273 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:764 Met Leu Asn Gly As n Ala Phe Arg 145 Gly Ala Val ***.Thr t..O Asn 225 Leu Tyr Phe Giu Sen Tyr Asp Lys Asn Phe Val Tyr 130 Ser Ile Ala Cys Ser 210 Ile Ile His Phe Met Lys Sen Ser Leu Gin Leu Gly Cys Thr Gly His Asn Pro Gly Ala Leu Gin Phe Lys 100 Tyr Gly Leu 115 Ala Pro Asn Asp Leu Leu.
Phe Gly Gly 165 Asn Tyr Trp 180 Thr Pro Thr 195 Thr Val Aia Tyr Lys His Asn Lys Phe 245 Leu Lys Arg 260 Lys Phe Val Ala Leu Gly Leu Leu Sen Ala Val Leu Gin Ser Gly 70 Asn Sen Phe Lys Ala 150 Val Lys Tyr Phe Asn 230 Leu Asp Ala Ala Val1 55 Gly Gly Leu Asp Ile 135 Asp Ala G 1u Cys Gln 215 Gly Sen Tyr Glu Arg 40 Val1 Thr Phe Asp Tyr 120 Gin Ile Ile Gin Asn 200 Val Val Ala Ser Gly 2S Leu Gly Asn G ly Met 105 Gly Leu Ile G ly Ile 185 Pro Trp Giu Gly Leu 265 Asp As n Cys Ile Leu 90 Thr His Asp Asp Gly 170 Ile Asn Leu Phe Pro 250 Gly Val Sen Asn Pro Pro Asn Trp 75 Asn Vai Ser Lys Ala Asp Met Vai 140 Lys Asp 155 Asn Thr Glu Ala Ala Pro Asn Phe 220 Gly Val 235 Asn Ala Tyr Ile Gly His Gly Trp Leu 125 Sen Asn Trp Lys Tyr 205 Gly Arg Thr Ile Tyr Leu Ser Tyr Phe 110 Gly Trp Ala Lys Gly 190 Sen Val Val Asn Gly Asn Thr Lys Lys G ly Lys Gly Ser Sen 175 Pro Thr Arg Pro Leu, Thr Thr Ala Tyr Lys Phe Gin Val1 Phe 160 Sen Asp Asn Ala Leu 240 Tyr Tyr Leu Gly Tyr 255 Asn Tyr Thr 270 INFORMATION FOR SEQ ID NO:764: SEQUENCE CHARACTERISTICS: LENGTH: 273 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .273 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:764 Met Giu Phe Met Lys Lys Phe Val Ala Leu Gly Leu Leu Ser Ala Val 1 Leu Asn Gly Asn Ala Phe Arg Val Gly 145 Gly Ala Val Thr Asn 225 Leu Phe 5 Leu G ly G ly Pro Leu Lys Leu Asn Leu Gly 165 Trp Thr Ala His Phe 245 Arg Leu Gin Ser Gly As n Ser Phe Lys Ala 150 Val Lys Tyr Phe Asn 230 Leu Asp Ala Glu Ala Arg Val Val Gly Thr Gly Phe Leu Asp Asp Tyr 120 Ile Gin 135 Asp Ile Ala Ile Glu Gin Cys Asn 200 Gin Val 215 Gly Val Ser Ala Tyr Ser 10 Gly Asp Leu Asn Gly Cys Asn Ile Gly Leu 90 Met Thr 105 Gly His Leu Asp Ile Asp Gly Gly 170 Ile Ile 185 Pro Asn Trp Leu Giu Phe Gly Pro 250 Leu Tyr 265 Tyr Ile Gly His Gly Trp Leu 125 Ser As n Trp Lys Tyr 205 Gly Arg Thr Ile Tyr Leu Ser Tyr Phe 110 Gly Trp Ala Lys G ly 190 Ser Vai Val1 Asn G ly Asn Thr Lys Lys Gly Lys Gly Ser Ser 175 Pro Thr Arg Pro Leu Thr Thr Ala Tyr Lys Phe Gin Val1 Phe 160 Ser Asp Asn Ala Leu 240 Tyr 255 Leu bly Tyr Asn Tyr Thr INFORMA)TION FOR SEQ ID NO:765: Wi SEQUENCE CHARACTERISTICS: LENGTH: 133 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: piotein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAE/KEY: misc-feature LOCATION .133 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:765 636 Met Asn Tyr Asp Asn Tyr Trp Asp Glu Asp Lys Pro Glu Leu Asn Ile 1 5 10 Thr Pro Leu Val Asp Val Met Leu Val Leu Leu Ala Ile Leu Met Val 25 Thr Thr Pro Thr Leu Thr Tyr Lys Glu Glu Ile Ala Leu Pro Ser Gly 40 Ser Lys Thr Ala Arg Ala Thr Gin Asp Lys Val Ile Glu Ile Arg Met 55 Asp Lys Asp Ala Lys Ile Tyr Ile Asp Ser Gin Thr Tyr Glu Tyr Unk 70 75 Ser Phe Pro Asp Thr Phe Asn Leu Leu Ser Lys Lys Tyr Asp Lys Asp 90 Thr Arg Val Ser Ile Arg Ala Asp Lys Arg Leu Thr Tyr Asp Lys Val 100 105 110 Ile Tyr Leu Leu Lys Thr Ile Lys Glu Ala Gly Phe Leu Lys Val Ser 115 120 125 Leu Ile Thr Ser Pro 130 INFORMATION FOR SEQ ID NO:765: SEQUENCE CHARACTERISTICS: LENGTH: 133 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE:.
NAME/KEY: misc_feature LOCATION 1...133 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:765 Met Asn Tyr Asp Asn Tyr Trp Asp Glu Asp Lys Pro Glu Leu Asn Ile 1 5 10 Thr Pro Leu Val Asp Val Met Leu Val Leu Leu Ala Ile Leu Met Val o 20 25 Thr Thr Pro Thr Leu Thr Tyr Lys Glu Glu Ile Ala Leu Pro Ser Gly S. 35 40 Ser Lys Thr Ala Arg Ala Thr Gin Asp Lys Val Ile Glu Ile Arg Met 55 Asp Lys Asp Ala Lys Ile Tyr Ile Asp Ser Gin Thr Tyr Glu Tyr Unk 70 75 Ser Phe Pro Asp Thr Phe Asn Leu Leu Ser Lys Lys Tyr Asp Lys Asp 90 Thr Arg Val Ser Ile Arg Ala Asp Lys Arg Leu Thr Tyr Asp Lys Val 100 105 110 Ile Tyr Leu Leu Lys Thr Ile Lys Glu Ala Gly Phe Leu Lys Val Ser 115 120 125 Leu Ile Thr Ser Pro 130 INFORMATION FOR SEQ ID NO:766: SEQUENCE CHARACTERISTICS: LENGTH: 71 amino acids TYPE: amino acid 637 TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...71 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:766 Met Pro Pro Thr Unk Pro Gin Ala Ser Ile Leu Arg Leu Thr Leu Lys 1 5 10 Asn Pro Leu Unk Unk Leu Ser Arg Tyr Ser Leu Cys Leu Leu Lys Lys 25 Thr Arg Leu Gln Thr Thr Ser Asn Ser Ala Pro Lys Ala Cys Leu Ile 40 Ala Gly Leu Leu Lys Lys Ser Lys Pro Phe Ile Leu Asn Thr Leu Lys 55 Ile Arg Ser Leu Leu Lys Pro INFORMATION FOR SEQ ID NO:766: SEQUENCE CHARACTERISTICS: LENGTH: 71 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein e (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori.
(ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...71 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:766 Met Pro Pro Thr Unk Pro Gin Ala Ser Ile Leu Arg Leu Thr Leu Lys 1 5 10 Asn Pro Leu Unk Unk Leu Ser Arg Tyr Ser Leu Cys Leu Leu Lys Lys 25 Thr Arg Leu Gin Thr Thr Ser Asn Ser Ala Pro Lys Ala Cys Leu Ile 40 Ala Gly Leu Leu Lys Lys Ser Lys Pro Phe Ile Leu Asn Thr Leu Lys 55 Ile Arg Ser Leu Leu Lys Pro INFORMATION FOR SEQ ID NO:767: SEQUENCE CHARACTERISTICS: LENGTH: 147 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...147 (xi) SEQUENCE DESCRIPTION: SEQ ID N0:767 Met Gly Cys Ser Phe Ile Phe Lys Lys Val Arg Val Tyr Ser Lys Met 1 5 10 Leu Val Ala Leu Gly Leu Ser Ser Val Leu Ile Gly Cys Ala Met Asn 25 Pro Ser Ala Glu Thr Lys Lys Pro Asn Asp Ala Lys Asn Gln Gin Pro 40 Val Gin Thr His Glu Arg Met Thr Thr Ser Ser Glu His Val Thr Pro 55 Leu Asp Phe Asn Tyr Pro Val His Ile Val Gin Ala Pro Gin Asn His 70 75 His Val Val Gly Ile Leu Met Pro Arg Ile Gin Val Ser Asp Asn Leu 85 90 Lys Pro Tyr Ile Asp Lys Phe Gin Asp Ala Leu Ile Asn Gin Ile Gln 100 105 110 Thr Ile Phe Glu Lys Arg Gly Tyr Gin Val Leu Arg Phe Gin Asp Glu S115 120 125 Lys Ala Leu Asn Val Gin Asp Lys Lys Lys Ile Phe Ser Val Leu Asp L e 130 135 140 Leu Lys Gly 145 INFORMATION FOR SEQ ID NO:768: SEQUENCE CHARACTERISTICS: LENGTH: 144 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...144 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:768 Met Asp Arg Lys Leu Leu Arg Leu Tyr Gin Pro Leu Asn Ala Tyr Ser 1 5 10 Tyr Asn Ser Asp Ser Leu Phe Leu Tyr Asp Phe Ser Arg Pro Phe Ile 25 Lys Asn Ser Gly Ala Ile Leu Asp Ile Gly Ser Gly Cys Gly Val Leu 40 Gly Leu Leu Cys Ala Arg Asp Asn Pro Leu Ala Ser Val His Leu Val 55 Glu Lys Asp Ser Lys Met Ala Phe Cys Ser Gin Lys Asn Ala Leu Lys 70 75 Phe Pro Asn Ala Gin Val Phe Glu Ser Asp Phe Leu Asp Phe Asn Pro 90 Pro Ile Leu Tyr Asp Ala Ile Val Cys Asn Pro Pro Phe Tyr Ala Leu 100 105 110 Gly Ser Ile Lys Ser Gln Ile Lys Gly His Ala Arg His Gin Ser Glu 115 120 125 Leu Asp Phe Ala Ser Leu Val Ala Lys Val Lys Lys Cys Leu Lys Pro 130 135 140 INFORMATION FOR SEQ ID NO:769: SEQUENCE CHARACTERISTICS: LENGTH: 47 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...47 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:769 SMet Leu Ser Ala Leu Val Met Leu Pro Phe Met Glu Val Phe Tyr Tyr S 1 5 10 Phe Asn Phe Pro Leu Trp Leu Asn Leu Phe Leu Gly Gin Thr Ile Gly 25 Ala Val Ile Phe Phe Lys Leu Asp Lys Leu Ile Phe Ser Lys Lys S35 40 INFORMATION FOR SEQ ID NO:770: SEQUENCE CHARACTERISTICS: LENGTH: 129 amino acids TYPE: amino acid TOPOLOGY: linear S(ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...129 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:770 Met Asn Thr Ile Ile Arg Tyr Ala Ser Leu Trp Gly Leu Cys Ile Thr 1 5 10 Leu Thr Leu Ala Gin Thr Pro Ser Lys Thr Pro Asp Glu Ile Lys Gin 25 Ile Leu Asn Asn Tyr Ser His Lys Asn Leu Lys Leu Ile Asp Unk Pro 40 640 Thr Ser Ser Leu Link Ala Thr Pro Gly Phe Link Pro Ser Pro Lys Glu 55 Thr Ala Thr Thr Ile Asn Gin Glu Ile Ala Lys Tyr His GlU Lys Ser 70 75 Asp Lys Ala Ala Leu Gly Leu Tyr Glu Leu Leu Lys Gly Ala Thr Thr 90 Asn Leu Ser Leu Gin Ala Gin Giu Leu Ser Val Lys Gin Ala Met Glu 100 105 110 Glu Pro His His Arg Gin Ser Asp Val Phe Ala Tyr Phe Glu Arg Glu 115 120 125 Leu INFORMATION FOR SEQ ID NO:771: SEQUENCE CHARACTERISTICS: LENGTH: 242 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .242 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:771 Met Val Leu Phe Leu Sen Ile Phe Lys Lys Ser Phe Asn Asp Phe Leu 1 5 10 Ser Ala Ang Met Leu Leu Ile Asn Leu Gly Pro Ile Leu Leu Ser Leu 25 Ala Phe Phe Giy Ala Ile Phe Tyr Tyr Asn Giy.Giy Ser Ile Val Asn 40 S Tyr Cys Gin Thr Leu Leu Pro Gin Ser Leu Asn Asp Tyr Ala His Ser 55 Gin Gly Phe Phe Ala Gly Val Phe Ala Trp Val Phe Lys Ala Leu Val 70 75 Tyr Phe Leu Ile Phe Trp Ile Val Ile Leu Leu Ser Leu Val Ile Asn Ile Phe Ala Sen Ile Phe Tyr Thr Pro Leu Val Val Ser Tyr Leu His 100 105 110 Gin Lys Tyr Tyr Pro His Vai Val Leu Giu Giu Phe Gly Ser Ile Leu 115 120 125 Phe Ser Ilie Lys Tyr Phe Leu Lys Ser Leu Thr Phe Met Leu Leu Phe 130 i-35 140 Leu Ala Val Leu Thn Pro Leu Tyr Phe Ile Pro Phe Ile Gly Val Phe 145 150 155 160 Giy Va. Phe Phe Ser Ile Vai Pro His Phe His Phe Phe Lys Asn Thr 165 170 175 Met Ser Leu Asp Ile Ala Ser Met Ile Phe Asn His Gin Ser Tyr Gin 180 185 190 Asn Leu Leu Lys Gin His Ang Leu Lys His Tyr Arg Phe Ser Phe Phe 195 200 205 Cys Tyr Leu Phe Ser Leu Ile Pro Phe Phe Asn Phe Phe Ala Thr Leu 210 215 220 Leu Gin Thn Leu Lys Leu Thr His Tyr Ile Phe Ile Phe Lys Giu Lys 225 230 235 240 Giu Cys INFORMATION FOR SEQ ID NO:772: SEQUENCE CHARACTERISTICS: LENGTH: 97 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...97 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:772 Met Gin Tyr Ala Asn Ala Tyr Gin Ala Tyr Gin His Asn Arg Val Ser 1 5 10 Val Glu Ser Pro Ala Lys Leu Ile Glu Met Leu Tyr Glu Gly Ile Leu 20 25 Arg Phe Ser Ser Gin Ala Lys Arg Cys Ile Glu Asn Glu Asp Ile Glu 35 40 S Lys Lys Ile Tyr Tyr Ile Asn Arg Val Thr Asp Ile Phe Thr Glu Leu 50 55 Leu Asn Ile Leu Asp Tyr Glu Lys Gly Gly Unk Val Ala Val Tyr Leu 65 70 75 Thr Gly Leu Tyr Thr His Gin Ile Lys Val Leu Thr Gin Ala Asn Val 90 S* Glu INFORMATION FOR SEQ ID NO:773: SEQUENCE CHARACTERISTICS: LENGTH: 143 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...143 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:773 Met Met Phe Asp Asn Thr Leu Ile Asn Leu Phe Glu Thr Ala Pro Leu 1 5 10 Leu Thr Ser Leu Leu Ala Gly Ile Leu Thr Phe Leu Ser Pro Cys Val 25 Leu Pro Leu Ile Pro Ala Tyr Met Ser Tyr Ile Ser Gin Ile Ser Leu 40 642 Glu Asp Ile Lys Asp Gly Lys Ala Lys Arg Val Ser Val Phe Leu Lys 55 Ser Leu Met Phe Val Val Gly Phe Ser Leu Val Phe Leu Gly Val Gly 70 75 Met Ser Met Ala Lys Leu Ile His Ser Phe Ser Phe Ser Trp Val Asn 90 Tyr Ile Ala Gly Gly Ile Val Ile Leu Phe Giy Leu His Phe Leu Gly 100 105 110 Val Phe Arg Phe Ala Phe Leu Tyr Lys Thr Gin Ser Val Gly Leu Ala 115 120 125 Ser Lys Ser Asn Ser Met Gin Arg Phe Thr Pro Phe Phe Leu Ala 130 135 140 INFORMATION FOR SEQ ID NO:774: SEQUENCE CHARACTERISTICS: LENGTH: 217 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .217 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:774 Met Pro Val Ile Arg Val Leu Val Met Leu Ala Thr Met Met Met Lys 1 5 10 Leu Val Lys Thr Ala Lys Glu Lys Lys Val Phe Lys Asn Val Gly Ile 25 Ser Ile Met Gly le Ala Phe Trp Glu Ala le. Lys Asp Ser Ile Lys 40 Lys Gin Ile Lys Lys Ser Asp Trp Ile Cys Gly Asn Val Lys Thr Ala 55 Asp Asp Tyr Leu Lys Thr His Pro Asn Sen Trp Phe Asn Sen Ala Ile 70 75 Gly Val Thn Ala Ile Thn Ala Met Leu Met Asn Val Cys Phe Ala Asp 90 Asp Gin Ser Lys Lys Giu Val Ala Gin Ala Gin Lys Glu Ala Giu Asn 100 105 110 Ala Axg Asp Ai-g Ala Asn Lys Ser Gly Ile Giu Leu Glu Gin Giu Giu 115 120 125 Gin Lys Thr Giu Gin Glu Lys Gin Lys Thn Glu Gin Giu Lys Gin Lys 130 135 140 Thn Giu Gin Giu Lys Gin Lys Thr Glu Gin Giu Lys Gin Lys Thn Glu 145 150 155 160 Gin Glu Lys Gin Lys Thn Sen Asn Ile Giu Thr Asn Asn Gin Ile Lys 165 170 175 Val Giu Gin Giu Gin Gin Lys Thr Giu Gin Glu Lys Gin Lys Thr Asn 180 185 190 Asn Thr Gin Lys Asp Leu Val Asn Lys Ala Glu Gin Asn Cys Gin Glu 195 200 205 Asn His Asn Gin Phe Phe Ile Lys Asn 210 215 INFORMATION FORSEQ ID NO:774: SEQUENCE CHARACTERISTICS: LENGTH: 217 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...217 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:774 Met Pro Val Ile Arg Val Leu Val Met Leu Ala Thr Met Met Met Lys 1 5 10 Leu Val Lys Thr Ala Lys Glu Lys Lys Val Phe Lys Asn Val Gly Ile 25 Ser Ile Met Gly Ile Ala Phe Trp Glu Ala Ile Lys Asp Ser Ile Lys 40 Lys Gln Ile Lys Lys Ser Asp Trp Ile Cys Gly Asn Val Lys Thr Ala 50 55 Asp Asp Tyr Leu Lys Thr His Pro Asn Ser Trp Phe Asn Ser Ala Ile 70 75 S Gly Val Thr Ala Ile Thr Ala Met Leu Met Asn Val Cys Phe Ala Asp 90 Asp Gin Ser Lys Lys Glu Val Ala Gin Ala Gin Lys Glu Ala Glu Asn 100 105 110 SAla Arg Asp Arg Ala Asn Lys Ser Gly Ile Glu Leu Glu Gin Glu Glu 115 120 125 Gin Lys Thr Glu Gin Glu Lys Gin Lys Thr Glu Gin Glu Lys Gin Lys 130 135 140 Thr Glu Gin Glu Lys Gin Lys Thr Glu Gln Glu Lys Gin Lys Thr Glu 145 150 155 160 Gin Glu Lys Gin Lys Thr Ser Asn Ile Glu Thr Asn Asn Gin Ile Lys 165 170 175 Val Glu Gin Glu Gin Gin Lys Thr Glu Gin Glu Lys Gin Lys Thr Asn 180 185 190 o Asn Thr Gin Lys Asp Leu Val Asn Lys Ala Glu Gin Asn Cys Gin Glu 195 200 205 Asn His Asn Gin Phe Phe Ile Lys Asn 210 215 INFORMATION FOR SEQ ID NO:775: SEQUENCE CHARACTERISTICS: LENGTH: 84 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature Val Arg Phe His Asp Leu LOCATION .84 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:775 Leu Vai Val Gly Lys Pro Asn Giu Ser Tyr Ala Asp Thr His 10 Ile Glu His Phe Ile Lys Leu Val Asp Phe Lys Gly Glu Ile 25 Ile Asn Giu Asp Asn Ser Ser Val Glu Ala Tyr Giu Asn Leu 40 Leu Gly Lys Lys Asn Lys Arg Ile Ala Thr Lys Asp Gly Arg 55 Ser Leu Ser Ala Cys Arg Ile Leu Glu Arg Tyr Cys Gin Gin 70 Lys Lys Gly se 9 .9 0* .9 9e 9. 9 0* 9**9 99** 9 9**9 9* 9 9 999 INFORMATION FOR SEQ ID NO:776: SEQUENCE CHARACTERISTICS: LENGTH: 75 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION (xi) SEQUENCE DESCRIPTION: SEQ ID NO:776 Met Val Ile Ser Gly His Phe Thr Thr Tyr Ser Tyr Ile Glu Pro Phe 1 5 10 Ile Ile Gin Ile Ser Gin Phe Ser Pro Asp Ile Thr Thr Leu Met Leu 20 25 Phe Val Phe Giy Leu Ala Gly Val Val Gly Sen Phe Leu Phe Gly Arg 35 40 Leu Tyr Ala Lys Asn Sen Ang Lys Phe Ile Ala Phe Ala Met Val Leu 50 55 Val Ile Cys Pro Gin Pro Leu Aia Phe Cys Val 70 INFORMATION FOR SEQ ID NO:776: SEQUENCE CHARACTERISTICS: LENGTH: 75 amino acids MB TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacten pyloni (ix) FEATURE: NAME/KEY: miscfeature LOCATION (xi) SEQUENCE DESCRIPTION: SEQ ID NO:776 Met Vai Ile Ser Giy His Phe Thr Thr Tyr Ser Tyr Ile Giu Pro Phe 1 5 10 is Ile Ile Gin Ile Ser Gin Phe Ser Pro Asp Ile Thr Thr Leu Met Leu 25 Phe Val Phe Gly Leu Ala Gly Val Val Giy Ser Phe Leu Phe Giy Arg 40 Leu Tyr Aia Lys Asn Ser Arg Lys Phe Ile Aia Phe Aia Met Val Leu 55 Val Ile Cys Pro Gin Pro Leu Aia Phe Cys Val 70 INFORMATION FOR SEQ ID NO:777: SEQUENCE CHARACTERISTICS: LENGTH: 155 amino acids TYPE: amino acid TOPOLOGY: iinear (ii) MOLECULE TYPE: protein HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .155 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:777 Met Arg Ile Leu Ile Leu Lys Asn Lys Pro Pro Thr Leu Arg Ser Lys 1 5 10 Ala Leu Thr Arg Ser Trp Gly Ile Asn Phe Ser.Leu Lys Asn Thr Leu 25 Ala Tyr Ala Phe Met Gly Phe Phe Asp Tyr Ala His Ala Asn Ser Ile 40 Lys Leu Lys Asn Pro Asn Tyr Asn Ser Giu Ala Ala Gin Val Ala Ser 55 Gin Ile Leu Gly Lys Gin Glu Ile Asn Arg Leu Thr Asn Ile Ala Asp a 65 70 75 Pro Arg Thr Phe Glu Pro Asn Met Leu Thr Tyr Gly Gly Ala Met Asp 90 Val Met Val Asn Val Ile Asn Asn Gly Ile Met Ser Leu Gly Ala Phe 100 105 110 Gly Gly Ile Gin Leu Ala Gly Asn Ser Trp Leu Met Ala tUnk Pro Ser 115 120 125 Phe Glu Gly Ilie Leu Gly Glu Gin Ala Leu Val Ser Arg Lys Pro Leu 130 135 140 Leu Ser Asn Phe Tyr Ser Met Trp Gly Leu Ala 145 150 155 INFORMATION FOR SEQ ID NO:778: SEQUENCE CHARACTERISTICS: LENGTH: 192 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .192 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:778 Met Lys Sen Thr Arg Ile Gly Ser Lys Ile Val Met Met Val Cys Ala 1 5 10 Val Val Ile Val Ile Ser Ala Val Met Gly Val Ile Ile Ser Tyr Lys 25 Val Giu Ser Val Leu Gin Ser Gin Ala Thr Giu Leu Leu Gin Lys Lys 40 Ala Gin Leu Val Ser Phe Lys Ile Gin Gly Ile Met Lys Arg Ile Phe 55 Met Gly Ala Asn Thn Leu Giu Arg Phe Leu Ser Asp Giu Asn Gly Ala 70 75 so '0000 le Asn Asp Thr Leu Lys Arg Arg Met Leu Sen Glu Phe Leu Leu Ala 00:85 90 Asn Pro His Val Leu Leu Val Sen Ala Ile Tyr Thr Asn Asn Asn Giu 100 105 110 S Ang Met Ile Thr Ala Met Asn Met Asp Ser Lys Ile Ala Tyr Pro Asn Aa115 120 125 Thr AaLeu Asn Glu Asn Met Thr Unk Pro Ile His Sen Leu Lys Ser ~"130 135 140 Ile Thr Ang Sen Unk Pro Tyr Tyr Lys Glu Val Asn Unk Unk Lys Ile 145 150 155 160 *Tyr Unk Unk Unk Ile Thr Leu Pro Leu Unk Unk Lys Asn Unk Asn Unk 165 170 175 Sle Unk Unk Leu Asn Phe Unk Leu Asn Ile Asp Unk Phe Leu Tyr Unk 180 185 190 INFORMATION FOR SEQ ID NO:778: SEQUENCE CHARACTERISTICS: LENGTH: 192 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 192 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:778 Met Lys Ser Thr Ang Ile Gly Sen Lys Ile Val Met Met Val Cys Ala 1 5 10 Val Val Ile Val Ile Sen Ala Val Met Gly Val Ile Ile Ser Tyr Lys 25 Val Giu Sen Val Leu Gin Sen Gin Ala Thr Glu Leu Leu Gin Lys Lys 40 Ala Gin Leu Val Ser Phe Lys Ile Gin Giy Ile Met Lys Arg Ile Phe 55 Met Gly Ala Asn Thr Leu Glu Arg Phe Leu Ser Asp Giu Asn Giy Ala 70 75 Ile Asn Asp Thr Leu Lys Arg Arg Met Leu Ser Glu Phe Leu Leu Ala 90 Asn Pro His Val Leu Leu Val Ser Ala Ile Tyr Thr Asn Asn Asn Giu 100 105 110 Arg Met Ile Thr Ala Met Asn Met Asp Ser Lys Ile Ala T~yr Pro Asn 115 120 125 Thr Ala Leu Asn Glu Asn Met Thr Unk Pro Ile His Ser Leu Lys Ser 130 135 140 Ile Thr Arg Ser Unk Pro Tyr Tyr Lys Glu Val Asn Unk Unk Lys Ile 145 150 155 160 Tyr Unk Unk Unk Ile Thr Leu Pro Leu Unk Unk Lys Asn Unk Asn Unk 165 170 175 Ile Unk Unk Leu Asn Phe Unk Leu Asn Ile Asp Unk Phe Leu Tyr Unk 180 185 190 INFORMATION FOR SEQ ID NO:779: SEQUENCE CHARACTERISTICS: LENGTH: 171 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 171 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:775 Met Asn Val Lys Lys Lys Giu Lys Pro Gin Sen Gly Lys Ile Asp Arg 1 5 10 is Val Asp Cys Leu Giu Lys Leu Gly Lys Giu Asn Thn Thr Phe Leu Ser 25 Ser Ile Ala Met Gly Sen Ile Gly Gin Leu Ala Ile Pro Ile Pro Gly 40 Val Gly Val Leu Ile Gly Gly Phe Val Gly Gly Val Met Ser Lys Thr 55 Phe Tyr Asp Val Ser Leu Thr Ile Phe Lys Glu Ala Lys Leu Ala Arg 70 75 Gin Ang Arg Ile Giu Ile Glu Lys Glu Cys Arg Giu Sen Ile Arg Gin 90 Leu Giu Met Tyr Gin Asn Gin Phe Asn Glu Val Phe Giu Arg Tyn Phe 100 105 110 His Gly Th Ile Lys Phe Phe Asn Giu Ser Phe Asp Giu Leu Glu Ang 115 120 125 Ala Leu Cys Ala Gly Asp Ala Asp Leu Ala Ile Ala Val Asn Asn Lys 130 135 140 Ile Gin Giu Gly Met Gly Gin Giu Leu Leu Phe Asp Asn Lys Gin Giu 145 150 155 160 Cys Trp, Giu Phe Ile Thr Ser Arg Lys Giu Gly 165 170 INFORMATION FOR SEQ ID NO:780: SEQUENCE CHARACTERISTICS: LENGTH: 141 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...141 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:780 Met Trp Pro Unk Lys Leu Phe Leu Lys Pro Leu Lys Glu Thr Ser Leu 1 5 10 Ala Leu Val Gly Val Ala Lys Asn Ile Lys Ile Val Ala Leu Lys Ala 25 Gly Leu Lys Arg Ala Tyr Leu Pro Asn Arg Ser Leu Ile Phe Phe Leu 35 40 Ile Lys Arg Tyr Leu Arg Phe Asp Lys Ser Gin Pro Phe Ile Ser Ile 50 55 Thr Ala Leu Leu Ala Phe Phe Gly Val Ala Val Gly Val Met Val Leu 65 70 75 Ile Val Ala Met Ala Ile Met Asn Gly Met Ser Lys Glu Phe Glu Lys 85 90 Lys Leu Phe Val Met Asn Tyr Pro Leu Thr Leu Tyr Thr Thr Ser Pro 100 105 110 Tyr Gly Ile Ser Glu Glu Val Val Gin Ala Leu Glu Lys Lys Phe Pro 115 120 125 Asn Leu Pro Phe Ser Unk Pro Ile Cys Lys Pro Lys Ala 130 135 140 INFORMATION FOR SEQ ID NO:781: SEQUENCE CHARACTERISTICS: LENGTH: 70 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...70 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:781 Met Val Ser Leu Leu Gly Ala Leu Lys Arg Thr Pro Cys Thr Asn Arg 1 5 10 Phe Tyr Leu Lys Ala Leu Leu Phe Ala Ile Phe Tyr His Ala Val Asn 25 Asn Phe Leu Thr Gin Cys Pro Pro His Gin Val Arg Glu Phe Phe Ser 40 Arg His Ala Gin Gly Trp Lys Arg Glu Thr Leu Pro Cys Ala Leu 55 Phe Gin Asn Ala Leu INFORMATION FOR SEQ ID NO:782: SEQUENCE CHARACTERISTICS: LENGTH: 153 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .153 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:782 a.
a a a.
a a Val 1 Gly Ile Ile Pro Gin Asp Ser Gin Glu 145 His Cys Thr Asn 50 Giu Axg Ala Pro Glu 130 Ser His Leu Unk Arg Leu Leu Asp Ser Gly His 35 Leu Leu Ser
L~YS
Asn 115 Pro His Ile Asn 40 Gly Lys Ala Met 120 Ser Asn Thr Lys Giy Arg Glu Phe Ala Glu Gly Ser Lys Leu Phe Phe Leu Thr Glu
INFORMATION
FOR SEQ ID NO:783: SEQUENCE CHARACTERISTICS: LENGTH: 183 .amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KE:Y: misc-feature LOCATION 1 .183 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:783 Met Ala Ile Trp Gly Trp Cys Phe Leu Phe Leu Ser Ser Leu Met Trp 1 5 10 Gly Ser Ser Met His Glu Leu Val Leu Arg Ser Gin Ala Leu Gly Phe 25 Giu Thr Arg Leu Val Gin Cys Asp Leu Ser Phe Ser Tyr Giu Arg Phe 40 Ile Ser Lys Thr Lys Arg Ser Leu Ala Val Leu Glu Giu Phe Asp Trp 55 Leu Asn Ser Gly Phe Asp Phe Ser Arg Leu Asn Val Glu Asn Asp Thr 70 75 Leu Giu Leu Leu Lys Ala Leu Tyr Phe Lys Leu Giu Lys Leu Giu Ser 90 Leu Leu Leu Lys Giu Asn Leu Leu Giu Leu Giu Gin Lys Asp Arg Ile 100 105 110 Ile Ala Leu Gly His Gly Leu Val Cys Leu Lys Lys Gin Ser Leu Ile 115 120 125 Ala Pro Gin Thr Tyr Tyr Gly Arg Cys Vai Leu Giu Gly Lys Ile Leu 130 135 140 Ala Phe Phe Gly Val Ala Arg Asp Lys Asp Phe Leu Glu Ile Thr Arg 145 150 155 160 Met His Ala Leu Asp Ile Lys Arg Tyr Asp Ser Phe Ile Val Asp Ser 165 170 175 Giu Arg Lys Gly Leu Lys Leu 180 INFORMATION FOR SEQ ID NO:784: SEQUENCE CHARACTERISTICS: LENGTH: 67 amino acids TYtPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAIr/KEY: misc-feature LOCATION 1 .67 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:784 Met Pro Giu Asn Ser Lys Leu Gin Pro Ala Lys Leu Gly Lys Asn Phe 1 5 10 Asp Pro Val Asp His Ser Agn Arg Asn Phe Phe Phe Sen Leu Ile Leu 25 Ser Val Leu Leu His Trp, Leu Ile Tyr Phe Leu Phe Glu His Arg Glu 40 Asp Phe Phe Pro Ser Lys Pro Lys Leu Val Lys Leu Asn Pro Giu Asn 55 Leu Leu Val INFORMATION FOR SEQ ID NO:785: SEQUENCE CHARACTERISTICS: LENGTH: 253 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/ KEY misc_feature LOCATION .253 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:785
S
S
*5
S
Met
I
Ser dly Arg Leu Gly Val Leu Val Asn 145 dly Lys Thr Gly Ile 225 Ala Ala Ser Glu His Gin Val' Asn Sen Lys 130 Arg Phe Thr Arg Val 210 Pro Asn Asp Lys Gly Leu Tyr Lys 115 Glu Gin Lys Ile Thr 195 Trp Ala Glu Leu Arg Asp Tyr Tyr Asn 100 Ile Met Ala Ser Leu 180 Leu Thr Cys Asp 5 Leu His Asp G ly Lys Lys Leu Cys Leu 165 Gly Sen Ala Ile Lys 245 Asp Asn Sen 70 Giu Lys Glu Asp Ser 150 Gin Arg Phe Ile Val 230 Lys Leu Glu Ala 55 Asn Ile Thr Arg Giu 135 Ala Leu Gly Leu Asp 215 Val Ser Phe Lys 40 Lys Ser Leu Glu Ser 120 Leu Ala Ala Leu Thr 200 Ile Ala Leu Giu 25 Leu Tyr Phe Cys Thr 105 Leu Sen Thr Val Ser 185 Gly Ala Thr Gin 10 Val1 Thr Ala Ala Asp 90 Thr Glu Ile Leu Ile 170 Leu Pro Gly Leu Ile 250 Leu Ser Glu Ser 75 Val1 Leu Glu Lys Thr 155 Val Ala Val Pro Arg 235 Glu Val1 Ser Arg Phe Cys Ile Met Asn 140 Leu Ala tiy Gly Ala 220 Leu Sen Phe Ile Ile Ile Asp Glu Asp 125 Thr Phe Asn Asn Trp 205 Tyr Lys Val Gly Glu Ala Lys Lys Gin 110 Asp Asp
LYS
Ala Gin 190 Ile Arg Thr Tyr Lys Tyr Asp Ang Asp Leu Glu Phe Leu Lys Gin Leu Lys Tyr Glu Gly Leu Asn Glu Asn Met Val 175 Val Ile Val Gin Glu Asp Lys Glu Glu Lys Met Glu Leu Gly 160 Ala Leu Thn Thn Gin 240 INFORMATION FOR SEQ ID NO:785: Wi SEQUENCE CHARACTERISTICS: LENGTH: 253 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .253 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:78S Met Ala Tyr Lys 1 Ser Ser Asp Leu Gly Giu Lys Arg Arg His Gly Asp Leu Gin Tyr Tyr Gly Val Leu Tyr Val Asn Tyr Asn 100 Leu Ser Lys Ile 115 Val Lys Glu Met 130 Asn Arg Gin Ala 145 Gly Phe Lys Ser Lys Thr Ile Leu 180 Thr Arg Thr Leu 195 Gly Val Trp Thr 210 Ile Pro Ala Cys 225 Ala Asn Glu Asn Asp Arg Asp Leu Glu Phe Leu Lys Gin Leu Glu Phe Ile Ile Ile Asp Glu Asp 125 Thr Phe Asn Asn Trp 205 Tyr Lys Val Gly Glu Ala Lys Lys Gin 110 Asp Asp Lys Ala Gin 190 Ile Arg Thr Lys Tyr Glu Gly Leu As n G lu Asn Met Val 175 Val Ile Val Gin a a a a.
a a. INFORMATION FOR SEQ ID NO:786: a a SEQUENCE CHARACTERISTICS: LENGTH: 173 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE-- ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .173 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:786 Val Phe Leu Val Gin Ser Trp Ala Leu Ser Leu Lys Ile Asp Ser Leu 10 Phe Ser Leu Phe Sen Val Gly Lys Ile Pro Sen Gly Sen Lys Asp Pro 25 Phe Ala Leu Arg Arj Leu Sen Phe Gly Leu Leu Lys Ile Ile Ala His 40 Tyr Gly Leu Glu Phe Asp Leu Lys Ala Asp Leu Lys Asn Leu Phe Giu 55 Lys Val Gly Vai Tyr Gin Ser Phe Asp Leu Glu Val Leu Giu Lys Phe 70 75 Leu Leu Glu Arg Phe His Asn Leu Ile Asp Cys Asn Leu Ser Ile Ile 90 Arg Ser Val Leu Asn Thr Asn Glu Arg Asp Ile Val Lys Ile Ile Gin 100 105 110 Lys Val Lys Ala Leu Lys Arg Phe Leu Asp Asn Pro Lys Asn Ala Gin 115 120 125 Lys Lys Glu Leu Leu Phe Ser Ala Phe Lys Arg Leu Ala Asn Ile Asn 130 135 140 Lys Asp Arg Asn Pro Asn Glu Ser Ser Giy Phe Ser Thr Ser Leu Phe 145 150 155 160 Lys Giu Leu Gin Giu His Ala Leu Phe Glu Ala Phe Asn 165 170 INFORMATION FOR SEQ ID NO:787: SEQUENCE CHARACTERISTICS: LENGTH: 259 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FAUE NAMtE/KEY: misc-feature LOCATION l...259 SEQUENCE DESCRIPTION: SEQ ID NO:787 Met Sen Leu Ala.Pro Sen Val Met Ala Gly Phe Lieu Phe Cys Ala Gly 1 5 10 Sen Cys; Sen Leu Ang Phe Pro Asn Tyr Sen Lys Ile Ile Sen Ile Asp 25 Val Asp Thr Val Phe Leu Gly Asp Val Ala Sen Ala Tyr Phe Ala Leu 40 Asp Asn Glu. Pro Thr Lys Leu Leu Gly Met Val Arg Asp Thn Phe Sen 55 His Leu, Pro Phe Giu Ala Phe Cys Asp Phe Cys Giu Arg Thr Cys Lys 70 75 Asn Phe Lys Ile Asp Leu Leu Arg Phe Ser Gin Asn Giu Leu Lys Arg 90 Ile His Gin Gly Phe Asn Met Gly Phe Leu Val Ala Asn Leu Asp Leu 100 105 110 *Tnp Arg Glu Asn Gly Phe Giu Lys Ile Ala Leu Glu Phe Leu Lys Thr 115 120 125 Arg Gly Lys Asp Leu Phe Tyr Pro Giu Gin Cys Leu Ile Asn Met Val 130 135 140 Phe Leu Giu Arg Ile Leu Giu Leu Pro Ile His Tyr Asn Cys Tyr Ser 145 150 155 160 Asp Phe Phe Lys Giu His Tyr Pro Lys Ser Ile Ile Met Leu His Phe 165 170 175 Ile Lys Tyr Lys Pro Trp Arg Sen Val Ser Ser Leu Asn Gly Arg Leu 180 185 190 Ile Cys Tyr Giu Ala Glu Ala Ser Phe Trp Leu Ala Asn Leu Phe Cys 195 200 205 654 Thr Pro Phe Lys Asn Asp Phe Phe Lys Giu Arg Leu Giu Met Ala Lys 210 215 220 Asp Gin Gin Met Gin Ser Phe Lys Thr H-is Ile Arg Ser Lys Thr Ile 225 230 235 240 Arg Asp Tyr Phe Tyr Phe Arg Ilie Lys Asn Ile Leu Lys Lys Val Phe 245 250 255 Giu Leu Ser INFORMATION FOR SEQ ID NO:788: SEQUENCE CHARACTERISTICS: CA) LENGTH: 293 amino acids TYPE: amino acid TOPOLOGY: iinear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature CB) LOCATION I1.. .293 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:788 Leu Leu Leu Phe Ile Vai Vai Ile Thr Ser Leu Vai Lys Asn Thr Ile 1 5 10 Pro Asn Ile Trp Leu Thr Lys Ile Leu Tyr Met Ala Ile Leu Leu Cys 25 Aia Ile Ala His Ser Vai Giy Unk Ile Leu Arg Trp Tyr Val Ser Gly *35 40 His Ser Pro Trp Sen Asn Ala Tyr Giu Ser Met Phe Tyr Ile Ala Trp 55 Ala Ser Val Ile Ala Gly Phe Vai Leu Ang Unk- Lys Leu Ala Leu Ser 70 75 Ala Sen Ser Phe Leu Ala Gly Ile Ala Leu Phe Val Ala His Leu Gly Phe Met Asp Pro Gin Ile Gly Pro Leu Val Pro Val Leu Lys Ser Tyr 100 105 110 Trp Leu Asn Ile His Val Ser Val Ile Thr Ala Sen Tyr Gly Phe Leu :*.115 120 125 Gly Leu Cys Phe Val Leu Gly Ile Leu Ser Leu Val Leu Phe Ile Leu 130 135 140 Arg Lys Gin Gly Ang Phe Asn Leu Asp Lys Thr Ile Leu Ser Ile Ser 145 150 155 160 Ala Ile Asn Giu Met Ser Met Ile Leu Gly Leu Phe Met Leu Thn Ala 165 -170 175 Gly Asn Phe Leu Gly Gly Val Trp, Ala Asn Giu Ser Trp Gly Arg Tyr 180 185 190 Tnp Gly Trp Asp Pro Lys Giu Thr Trp Ala Leu Ile Ser Ile Cys Val 195 200 205 Tyr Ala Leu Ile Leu His Leu Arg Phe Leu Gly Ser Gin Asn Trp Pro 210 215 220 Phe Ile Leu Ala Sen Sen Ser Val Leu Gly Phe Tyr Sen Val Leu Met 225 .230 235 240 Thr Leu Phe Trp Arg Giu Leu Leu Pro Phe Trp Leu Ala Gin Leu Cys 245 250 255 Arg Arg Unk Sen Phe Ala Asp Pro Tyn Phe Phe Ile Leu Phe Gly Ser 260 265 270 Asp Thr Phe Ang Ser -Ang Ile Leu Ala Tyr Phe Lys Arg His Leu Sen 275 280 Leu Pro Lys Leu Val 290 INFORMATION FOR SEQ ID NO:788: SEQUENCE CHARACTERISTICS: LENGTH: 293 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .293 (xi) SEQUENCE DESCRIPTION: SEQ 1D NO:788
S*
S
S S S. S S
S.
S
S S
S
Leu 1 Pro Ala His Ala Ala The Trp Gly Arg 145 Ala Gly Trp Tyr Phc 22! Leu Asn Ile Ser 50 Ser Ser Met Leu Leu 130 Lys Ile Asn Gly Ala 210 Ile jeu Phe Ile Vai Val Ile Thr Ser Leu Val Lys Asn Thr Ile Ilie kla 35 Pro VJal Ser Asp Asn 115 Cys Gin Asn Phe Trp 195 Leu Leu Trp 20 His Trp Ile Phe Pro 100 Ile Phe Gly Giu Leu 180 Asp Ile Ala .eu Thr Lys Ile I 3er Val Gly Unk 40 3er Asn Ala Tyr 55 kla Gly Phe Val 70 Ueu Ala Gly Ile 85 31n Ile Gly Pro His Val Ser Vai 120 Val Leu Gly Ile 135 Arg Phe Asn Leu 150 Met Ser Met Ile 165 Gly Gly Vai Trp Pro Lys Giu Thr 200 Leu His Leu Arg 215 Sen Sen Sen Val 230 Ang Glu Leu Leu 245 Phe Ala Asp Pro ,eu Ilie 3iu Leu 105 Ile Leu Asp Leu Aia 185 Trph Let Pnc 26! Al Tyr Met Leu Arg Ser Met Arg Unk 75 Leu Phe 90 Val Pro Thr Ala Ser Leu Lys Thr 155 Gly Leu 170 Asn Glu Ala Leu Leu Gly Gly Phe 235 Ala rrp Phe Lys Val Val Ser Val 140 Ile Phe Sen Ile Ser 220C Let Ly: 'lyr Tyr Leu Aia Leu Tyr 125 Leu Leu Met Trp Ser 205 Gin Ser Ala SLeu s Ang 285 4 eu lal Ilie Ala His Lys 110 G ly Phe Ser Leu Gly 190 Ile Asn Val Gir Ph 27 Hi: LeuC Ser Ala Leu Leu Sen Phe Ile Ile Thr 175 *Arg Cys Trp *Leu iLeu 255 Gly 0 s Leu -ys 'ly L'rp Ser .Gly Tyr Leu Leu Ser 160 Ala Tyr Val Pro Met 240 Cys Ser Sen Thr Leu Phe Trp Ang Arg Unk Sen 260 Phe 250 SPhe a. Tyr Trp Phe Phe Asp Thr Phe Arg Sen Ag Ile LeU 275 280 Leu Pro Lys Leu Val 290 INFORMATION FOR SEQ ID NO:789: SEQUENCE CHARACTERISTICS: LENGTH: 194 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...194 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:789 Val Ile Val Cys Ser Ala Ala Gly Leu Ser His Phe Phe Gly Phe Ser 1 5 10 Met Ser Leu Gly Ala Phe Ile Val Gly Met Ala Ile Ser Lys Ser Arg 25 Tyr Lys Ile Asn Val Gin Glu Glu Phe Ala Gin Leu Lys Asn Leu Phe 35 40 eo Leu Ala Leu Phe Phe Ile Thr Ile Gly Met Gin Ile Asn Val Ser Phe 50 55 Phe Met Glu Lys Phe Phe Val Val Ile Phe Leu Leu Ile Leu Val Met 65 70 75 Ser Phe Lys Thr Phe Ile Ile Tyr Ala Leu Leu Arg Phe Phe Arg Asp 85 90 Ala Lys Thr Ala Ile Lys Thr Ala Leu Ser Leu Ala Gin Ile Gly Glu 100 105 110 Phe Ser Phe Val Ile Phe Leu Asn Ser Gly Ser His Gin Leu Phe Asn 115 120 125 Leu Gin Glu Lys Lys Gly Ile Leu Gly Phe Leu His Gin Lys Asn Ile 130 135 140 Leu Asn Ile Ala Gin Asn Asp Ile His Gin Leu. Leu Ile Leu Met Val 145 150 155 160 Val Phe Ser Met Leu Ala Thr Pro Phe Ile Leu Lys Tyr Leu Glu Ser 165 170 175 Ile Ala Gin Phe Ile Leu His Gin Lys Ser Gln Glu Asn Glu Pro Ala 180 185 190 Lys Lys 9e INFORMATION FOR SEQ ID NO:790: SEQUENCE CHARACTERISTICS: LENGTH: 132 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...132 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:790 Met Phe Tyr Leu Ile Asn Thr Gly Val Pro His Leu Val Gly Phe Val 1 5 10 Lys Asn Lys Gly Leu Leu Asn Ser Leu Asn Thr Leu Glu Leu Arg Ala 25 Leu Arg His Glu Phe Asn Ala Asn Ile Asn Ile Ala Phe Ile Glu Asn 40 Lys Glu Thr Ile Phe Leu Gin Thr Tyr Glu Arg Gly Val Glu Asp Phe 55 Thr Leu Ala Cys Gly Thr Gly Met Ala Ala Val Phe Ile Ala Ala Arg 70 75 Leu Phe His Asn Thr Pro Lys Lys Ala Thr Leu Ile Pro Lys Ser Asn 90 Glu Phe Leu Glu Leu Ser Leu Lys Asn Asp Gly Ile Phe Tyr Lys Gly 100 105 110 Val Ala Arg Tyr Ile Gly Met Ser Val Leu Gly Met Gly Val Phe Lys 115 120 125 Asn Gly Cys Phe 130 INFORMATION FOR SEQ ID NO:791: SEQUENCE CHARACTERISTICS: LENGTH: 213 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein *e (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori Ce 9 (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...213 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:791 Met Ile Lys Ala Ile Asp Ile Ser His Asp Phe Glu Lys Pro Leu Tyr 1 5 10 Asn Gly Val Asn Leu Arg Ile Lys Pro Lys Glu Ser Met Glu Ile Leu 20 25 Gly Val Ser Gly Ser Gly Lys Ser Thr Leu Ile Ser His Leu Ala Thr 40 Met Leu Lys Pro Asp Ser Gly Thr Val Ser Leu Leu Glu His Gin Asp 55 Ile Tyr Ala Leu Asn Ser Lys Lys Leu Leu Glu Leu Arg Arg Leu Lys 70 75 Val Gly Ile Val Phe Gin Ser His Tyr Leu Phe Lys Gly Phe Ser Ala 90 Leu Glu Asn Leu Gln Val Ala Ser Ile Leu Ala Lys Gin Glu Ile Asn 100 105 110 His Ser Leu Leu Glu Gin Leu Gly Ile Ala His Thr Leu Lys Gin Gly 115 120 125 Val Gly Glu Leu Ser Gly Gly Gin Gin Gin Arg Leu Ser Ile Ala Arg 130 135 140 Val Leu Ser Lys Lys Pro Gin Ile Ile Ile Ala Asp Glu Pro Thr Gly 145 150 155 160 Asn Leu Asp Thr Thr Ser Ala Asn Gin Val Ile Ser Met Leu Gin Asn 165 170 175
I
658 Tyr Ile Thr Glu Asn Glu Gly Ala Leu Val Leu Ala Thr His Asp Glu 180 185 190 His Leu Ala Phe Thr Cys Ser Gin Val Tyr Arg Leu Glu Lys Glu Ser 195 200 205 Leu Ile Lys Glu Lys 210 INFORMATION FOR SEQ ID NO:792: SEQUENCE CHARACTERISTICS: LENGTH: 47 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...47 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:792 Met Leu Asp Lys Arg Ile Lys Thr Leu Leu Leu Phe Phe Gly Leu Asn 1 5 10 Met Val Cys Leu Ser Val Ser Phe Thr Asn Lys Pro His Leu Cys Phe 20 25 Trp Phe Leu Val Leu Gly Cys Tyr Leu Val Tyr Glu Trp Gin Lys 40 INFORMATION FOR SEQ ID NO:793: SEQUENCE CHARACTERISTICS: LENGTH: 142 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...142 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:793 Val Glu Met Ile His Thr Gln Asp Tyr Ile Lys Met Glu Glu Ala Ala 1 5 10 Thr Glu Ala Ile Lys Arg Lys Glu Ser Ser Ile Tyr Leu Gly Met Asp 25 Ile Leu Lys Asn Gly Ala Asp Ala Leu Ile Ser Ala Gly His Ser Gly 40 Ala Thr Met Gly Leu Ala Thr Leu Arg Leu Gly Arg Ile Lys Gly Val 55 Glu Arg Pro Ala Ile Cys Thr Leu Met Pro Ser Val Gly Lys Arg Pro Ser Leu His Ile 70 75 Leu Leu Asp Ala Gly Ala Asn Thr Asp 90 Asp Phe Ala Leu Met Gly Tyr Glu Tyr 100 105 Asp Ser Pro Lys Val Gly Leu Leu Ser 115 120 Gly Gly Ile Arg Ser Leu Lys Lys Arg 135 Cys Lys Pro Glu Tyr Ala Lys Ser Val Leu 110 Asn Gly Glu Glu Asp 125 Ile Lys Cys 140 INFORMATION FOR SEQ ID NO:793: SEQUENCE CHARACTERISTICS: LENGTH: 142 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...142 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:793 Val Glu Met Ile His Thr Gln Asp Tyr Ile Lys Met Glu Glu Ala Ala 1 Thr Ile Ala Glu Ser Leu His Ile Glu Leu Thr Arg Val Ile Tyr Lys 130 Ala Lys Met Pro Leu Asp Asp 115 Gly Ile Asn Gly Ala Leu Phe 100 Ser Gly Leu Gly Ile Gly Lys Lys Gly 125 Lys Gly His Lys Lys Pro Ser 110 Glu Cys Met Ser Gly Arg Glu Val Glu Asp Gly Val Pro Tyr Leu Asp 0* Lys Lys Arg INFORMATION FOR SEQ ID NO:794: SEQUENCE CHARACTERISTICS: LENGTH: 69 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...69 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:794 Met Lys Thr Ile Lys Asn Gly Ile Met Ile Gly Thr Leu Gly Ala Leu 1 5 10 Leu Leu Ser Gly Cys Ser Ser Phe Asp Ala Gin Arg Phe Ala Cys Leu 25 Pro Lys Asp His Ser Ser Lys Asp Ala Ser Thr Lys Lys Glu Ala Gln 40 Tyr Ile Pro Lys Gly Phe Phe Asp Pro Tyr Ser Ser Asn Leu Asn His 55 Trp Asp Ser Thr Phe INFORMATION FOR SEQ ID NO:795: SEQUENCE CHARACTERISTICS: LENGTH: 144 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...144 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:795 Met Leu Glu Ile Lys Asn Leu Asn Cys Val Leu.Asn Ser His Phe Ser 1 5 10 Leu Gin Asn Ile Asn Ile Ser Leu Ser Tyr Ser Glu Arg Val Ala Ile 20 25 Val Gly Glu Ser Gly Ser Gly Lys Ser Ser Ile Ala Asn Leu Val Met 40 Arg Leu Asn Pro Arg Phe Lys Ser His Asn Gly Glu Ile Leu Phe Glu 55 Thr Thr Asn Leu Leu Lys Glu Ser Glu Ala Phe Unk Gin His Leu Arg 70 75 Gly Asn Ile Ile Ala Tyr Ile Ala Gin Asp Pro Leu Ser Ser Leu Asn 90 Pro Leu His Lys Ile Gly Lys Gin Met Ser Glu Ala Tyr Phe Leu His 100 105 110 His Lys Asn Ala Ser Gin Val Ser Leu Asn Glu Gin Val Leu Asn Val 115 120 125 Met Lys Gin Val Gin Leu Asp Glu Asn Phe Trp Asn Val Ser Leu Met 130 135 140 INFORMATION FOR SEQ ID NO:795: SEQUENCE CHARACTERISTICS: LENGTH: 144 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...144 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:795 Met Leu Glu Ile Lys Asn Leu Asn Cys Val Leu Asn Ser His Phe Ser 1 5 10 Leu Gin Asn Ile Asn Ile Ser Leu Ser Tyr Ser Glu Arg Val Ala Ile 25 Val Gly Glu Ser Gly Ser Gly Lys Ser Ser Ile Ala Asn Leu Val Met 40 Arg Leu Asn Pro Arg Phe Lys Ser His Asn Gly Glu Ile Leu Phe Glu 55 Thr Thr Asn Leu Leu Lys Glu Ser Glu Ala Phe Unk Gin His Leu Arg 70 75 Gly Asn Ile Ile Ala Tyr Ile Ala Gin Asp Pro Leu Ser Ser Leu Asn 85 90 ro Leu His Lys Ile Gly Lys Gin Met Ser Glu Ala Tyr Phe Leu His 100 105 110 His Lys Asn Ala Ser Gin Val Ser Leu Asn Glu Gin Val Leu Asn Val 115 120 125 Met Lys Gin Val Gin Leu Asp Glu Asn Phe Trp Asn Val Ser Leu Met 130 135 140 INFORMATION FOR SEQ ID NO:796: .o e SEQUENCE CHARACTERISTICS: LENGTH: 190 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...190 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:796 Met Glu Leu Ile Leu Gly Ser Gin Ser Ser Ala Arg Ala Asn Leu Leu 1 5 10 Lys Glu His Gly Ile Lys Phe Glu Gin Lys Ala Leu Tyr Phe Asp Glu 25 Glu Ser Leu Lys Thr Thr Asp Pro Arg Glu Phe Val Tyr Leu Ala Cys 40 Lys Gly Lys Leu Glu Lys Ala Lys Glu Leu Leu Ala Asn Asn Cys Ala 55 Ile Val Val Ala Asp Ser Val Val Ser Val Gly Asn Arg Met Gin Arg 70 75 Lys Ala Lys Asn Lys Arg Glu Ala Leu Glu Phe Leu Lys Arg Gin Asn 90 662 Ala Leu Ile Gly Leu Asp Ser 145 Ser Leu Asn Glu Cys 130 Ala Ser Leu Glu Trp 115 Ser Gly Ser Gly Glu Val Asp Leu Ile Glu Val Arg 150 Asn Leu 165 Leu Lys Leu Ser Lys 135 Leu Ser Leu Thr Val 120 Tyr Glu Val Gly Cys 105 Phe Leu Asp Gly Val 185 Leu 125 Leu Pro Asn Leu Ser 110 Lys Trp Tyr Val Leu 190 Pro Val Ala Phe Gin Gly Ile Lys 160 Glu Gly 175
S
*5
S.
S.
S
a INFORMATION FOR SEQ ID NO:797: SEQUENCE CHARACTERISTICS: LENGTH: 83 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...83 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:797 Met Asn Tyr Lys Val Ala Ser Ala Arg Asn Ile Ala Thr Leu Leu 1 5 10 Leu Phe Phe Ser Gin Ser Glu Ala Phe Asp Leu Gly Lys Ile Ala 20 25 Ile Lys Ala Gly Ala Glu Ser Phe Ser Lys VaL Gly Phe Asn Asn 40 Pro Ile Asn Unk Asn Lys Gly Ile Tyr Pro Thr Glu Thr Phe Met 55 Ile Asn Gly Leu His Ala Gly Gly Phe Tyr Gly Ala Leu Ala Gin 70 Arg Tyr Gly INFORMATION FOR SEQ ID NO:797: SEQUENCE CHARACTERISTICS: LENGTH: 83-amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...83 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:797 Met Asn Tyr Lys Val Ala Ser Ala Arg Asn Ile Ala Thr Leu Leu Phe 1 5 10 Leu Phe Phe Ser Gin Ser Glu Ala Phe Asp Leu Gly Lys Ile Ala Lys 25 Ile Lys Ala Gly Ala Glu Ser Phe Ser Lys Val Gly Phe Asn Asn Lys 40 Pro Ile Asn Unk Asn Lys Gly Ile Tyr Pro Thr Glu Thr Phe Met Thr 55 Ile Asn Gly Leu His Ala Gly Gly Phe Tyr Gly Ala Leu Ala Gin Lys 70 75 Arg Tyr Gly INFORMATION FOR SEQ ID NO:798: SEQUENCE CHARACTERISTICS: LENGTH: 135 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: S NAME/KEY: misc_feature LOCATION 1...135 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:798 SMet Leu Ile Leu Gly His Pro Leu Ile Pro Ser Ala Arg Phe Val Phe 1 5 10 Ile Lys Asn Thr Asp Ala Ile His Ser Ser Ala Asn Asn Asp Ile Val 20 25 Cys Phe Glu Ala Asn Pro Lys Asn Leu Glu Leu Ala Gin Tyr Cys Cys 35 40 Glu Asn Gly Val His Phe Ser Val Ile Phe Leu Ser His Lys Ile Glu 50 55 Thr Asp Thr Phe Phe Leu Phe Asn Ala Phe Lys Pro Leu Tyr Cys Ile 70 75 Phe Lys Asp Ile Lys Gin Ala Ile Leu Ala Gin Gin His Ala Thr Asn 90 Tyr Leu Leu Asp Ser Lys Ile Leu Phe Ser Met Asp Phe Asn Asp Thr 100 105 110 Glu Ser Trp Glu Ile Cys Ala Lys Asn Gin Ile Asp Gly Val Ile Ser 115 120 125 Lys Asp Ser Leu Leu Leu Lys 130 135 INFORMATION FOR SEQ ID NO:799: SEQUENCE CHARACTERISTICS: LENGTH: 255 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .255 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:799 a a.
a. a a a a..
a. *a a a a Met Ser Arg Lys Val Val Ala Leu Cys Asn 145 Ile
LYS
Ile Ala Glu 225 Ser Lys Thr Ala Lys Ile Glu Phe Glu Giy 130 His Leu Asp Lys Tyr 210 Lys Ile Lys Val1 Gly His Giu Ala Val Gin 115 Gly Ile Ser Ala Gly 195 Gly Ile
LYS
Arg Ala Val Lys Asp Pro Thr 100 Ile Ile Leu Gin Gin 180 Ile Ile Glu Leu Lys Giu Gly Lys Tyr 85 Ala Ala Pro Ser Met 165 His Asp Asp Pro Leu 245 Leu Asn Ile Gly Leu Val Ile I le Gly 70 Leu Asn Lys Ile Phe 150 Phe Leu Ala Ala Asp 230 Gly Leu Lys Ala 55 Ile Leu Lys As n Ile 135 Lys Lys Gly Ala Lys 215 Asp Ile Gin Ile 40 Phe Asp Ala Ala Thr 120 Lys Gly Asn Tyr His 200 Leu Met Ala Glu 25 Lys G lu Ile Lys Met 105 Pro Ala Ile Gin Ala 185 Lys Glu Glu Lys 10 Asn Lys Ile Val1 Lys 90 Leu Ile Leu Leu Ala 170 Glu Leu Glu Phe Lys 250 Gly Leu Gln Giu Ala Val Sen Asp Val Glu 75 Thr Leu Ala Tyr Gly Phe Lys Asp 140 Asn Gly 155 Ser Phe Leu Asn Leu Ile Ile. Leu 220 Ala Lys 235 His Gin Gly Ile Val1 Asp Leu Ala His Glu 125 G ly Thr Lys Pro Leu 205 Ile Glu G ly Cys Ile Ang Leu Met Lys Arg 110 Ala Leu Ser Asp Glu 190 Ala Glu Phe Leu Val Lys Asp Giu Gly Gin Tyr Ser Sen As n Ala 175 Phe Sen Gly Gly His 255 Gly Asp Val1 Ser G ly Lys Glu Val1 Ala Tyr 160 Leu Asp Leu Ile Tyr 240 INFORMATION FOR SEQ ID NO:800: SEQUENCE CHARACTERISTICS: LENGTH: 243 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .243 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:800 665 Met Gin Glu Lys Arg Leu Lys Ala lie Gin Asn Lys Ile Ala Ser Trp 1 5 10 is Ile Lys Giu Ile Giu Ser Gly Phe Ile Asp Ala Leu Phe Ser Lys Ile 25 Gly Pro Ser Lys Met Leu Arg Ser Lys Leu Met Leu Ala Leu Leu Asp 40 Glu Lys Thr Asp Ala Ile Leu Leu Asp Lys Ala Leu Asn Leu Cys Ala 55 Ile Val Giu Met Ile Gin Thr Ala Ser Leu Leu His Asp Asp Val Ile 70 75 Asp Lys Ala Thr Met Arg Arg Lys Leu Pro Ser Ile Asn Ala Leu Phe 90 Gly Asn Phe Asn Ala Val Met Leu Gly Asp Val Phe Tyr Ser Lys Ala 100 105 110 Phe Phe Glu Leu Ser Lys Met Gly Giu Ser Ile Ala Gin Ala Leu Ser 115 120 125 Asn Ala Val Leu Arg Leu Ser Arg Gly Glu Ile Giu Asp Val Phe Val 130 135 140 Gly Giu Cys Phe Asn Ser Asp Lys Gin Lys Tyr Trp Arg Ile Leu Giu 145 150 155 160 Asp Lys Thr Ala His Phe Ile Glu Ala Ser Leu Lys Ser Met Ala Ile 165 170 175 Lau Leu Asn Lys Asp Ala Lys Met Tyr Ala Asp Phe Gly Leu His Phe 180 185 190 Giy Met Ala Phe Gin Ile Ile Asp Asp Leu Leu Asp Ile Thr Gin Asp 195 200 Ala Asn Thr Leu Gly Lys Pro Asn Phe Ser Asp Phe Lys Glu Gly Lys *.210 215 220 Thr Thr Leu Pro Tyr Leu Leu Leu Tyr Giu Lys Leu Asn Gin His Giu 225 230 235 240 Gin Gly Phe INFORMATION FOR SEQ ID NO:801: SEQUENCE CHARACTERISTICS: LENGTH: 252 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .252 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:801 Met Leu Gly Lys Lys Asn Giu Glu Val Leu Ile Asp Giu Asn Leu Val 1 5 10 Gly Giy Val Ile Ala Leu Asp Arg Leu Ala Lys Leu Asn Lys Ala Asn 25 Arg Thr Phe Lys Arg Ala Phe Tyr Leu Ser Met Val Leu Asn Val Ala 40 Ala Val Thr Ser Ile Val Met Met Met Pro Leu Lys Lys Thr Asp Ile s0 55 Phe Val Tyr Gly Ile Asp Arg Tyr Thr Gly Giu Phe Lys Ile Val Lys 70 75 666 Arg Ser Asp Ala Arg Gin Ile Val Asn Ser Glu Ala Val Val Asp Ser 90 Ala Thr Ser Lys Phe Val Ser Leu Leu Phe Gly Tyr Ser Lys Asn Ser 100 105 110 Leu Arg Asp Arg Lys Asp Gin Leu Met Gln Tyr Cys Asp Val Ser Phe 115 120 125 Gin Thr Gin Ala Met Arg Met Phe Asn Glu Asn Ile Arg Gin Phe Val 130 135 140 Asp Lys Val Arg Ala Glu Ala Ile Ile Ser Ser Asn Ile Gin Arg Glu 145 150 155 160 Lys Val Lys Asn Ser Pro Leu Thr Arg Leu Thr Phe Phe Ile Thr Ile 165 170 175 Lys Ile Thr Pro Asp Thr Met Glu Asn Tyr Glu Tyr Ile Thr Lys Lys 180 185 190 Gin Val Thr Ile Tyr Tyr Asp Phe Ala Arg Gly Asn Ser Ser Gin Glu 195 200 205 Asn Leu Ile Ile Asn Pro Phe Gly Phe Lys Val Phe Asp Ile Gin Ile 210 215 220 Thr Asp Leu Gin Asn Glu Gin Thr Val Ser Glu Ile Leu Arg Lys Ile 225 230 235 240 Lys Glu Val Glu Ser Lys Asn Lys Ala Leu Asn Lys 245 250 INFORMATION FOR SEQ ID NO:802: SEQUENCE CHARACTERISTICS: LENGTH: 165 amino acids S" TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...165 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:802 Met Arg Ala Ile Ala Ile Val Leu Ala Arg Ser Ser Ser Lys Arg Ile 1 5 10 Lys Asn Lys Asn Met Ile Asp Phe Phe Asn Lys Pro Met Leu Ala Tyr 25 Pro Ile Glu Thr Ala Leu Asn Ser Lys Leu Phe Glu Lys Val Phe Ile 40 Ser Ser Asp Ser Met Glu Tyr Val Asn Leu Ala Lys Asn Tyr Gly Ala 55 Ser Phe Leu Asn Leu Arg Pro Lys Asn Leu Ala Asp Asp Arg Ala Thr 70 75 Thr Leu Glu Val Met Ala Tyr His Met Lys Glu Leu Glu Leu Lys Asp 90 Glu Asp Ile Ala Cys Cys Leu Tyr Gly Val Ser Val Phe Leu Gin Glu 100 105 110 Lys His Leu Gin Asn Ala Phe Glu Thr Leu Lys Gin Asn Gin Asn Thr 115 120 125 Asp Tyr Val Phe Thr Cys Ser Pro Phe Ser Ala Ser Pro Ile Val Leu 130 135 140 Leu Ala Leu Lys Thr Ala Phe Lys Trp Leu Leu Lys Ser Ile Gin Thr 145 150 155 160 Arg Ala Arg Lys Ile: r 165 INFORMATION FOR SEQ ID NO:803: SEQUENCE CHARACTERISTICS: LENGTH: 171 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...171 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:803 Met Ser Asn Gin Ala Ser His Leu Asp Asn Phe Met Asn Ala Lys Asn 1 5 10 Pro Lys Ser Phe Phe Asp Asn Lys Gly Asn Thr Lys Phe Ile Ala Ile 20 25 Thr Ser Gly Lys Gly Gly Val Gly Lys Ser Asn Ile Ser Ala Asn Leu 40 o Ala Tyr Ser Leu Tyr Lys Lys Gly Tyr Lys Val Gly Val Phe Asp Ala 55 Asn Ile Gly Leu Ala Asn Leu Asp Val Ile Phe Gly Val Lys Thr Gin 70 75 Lys Asn Ile Leu His Asp Leu Lys Gly Glu Asp Lys Leu Lys Glu Ile 85 90 Ile Cys Glu Ile Glu Pro Gly Leu Cys Leu Ile Pro Gly Asp Ser Gly 100 105 110 Glu Glu Ile Leu Lys Tyr Ile Ser Glu Ala Glu Asp Phe Asp Ser Phe 115 120 125 Leu Asp Glu Glu Gly Val Leu Ser Ala Leu Ile'Tyr Ile Leu Ile Asn S130 135 140 Thr Phe Ser Lys Asn Leu Gly Pro Leu Ser Gin Thr Phe Leu Asn Phe •o 145 150 155 160 Gin Ser Phe Leu Phe Ile Phe Ile Gin Ser Pro 165 170 INFORMATION FOR SEQ ID NO:804: SEQUENCE CHARACTERISTICS: LENGTH: 62 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...62 Met 1 Leu Asp Glu 668 (xi) SEQUENCE DESCRIPTION; SEQ ID NO:804 Gin His Leu Vai Leu Ile Gly Phe Met Gy Ser Gly Lys Ser Ser S 10 Ala Gin Giu Leu Gly Leu Ala Leu Lys Leu Glu Val Leu Asp Thr 25 Met Ilie Ile Ser Glu Arg Val Gly Leu Ser Val Arg Gly Ile Phe 40 Giu Leu Gly Giu Asp Asn Phe Arg Met Phe Glu Lys Ile so 55 INFORMATION FOR SEQ ID NO:805: SEQUENCE CHARACTERISTICS: LENGTH: 199 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .199 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:805
S.
S
555 Met Asp Arg Leu Arg Ala TIyr Arg Sen Ile 145 Glu Ile Tyr er Ilie Lys Giu Asn Leu Giu Gin Val Ang Asn Glu Gly 50 Ile Leu Gin Leu Tyr 130 Leu Asn Pro Gl~f Lys Lys 35 Asp Thr Gin Phe Ser 115 Ala Lys Sen Leu Met 195 5 Leu Leu Glu 20 Trp Val Leu Thn Lys Leu Gin Ile Tyr 70 Lys Ang Leu 85 Ala Arg Ala 100 Gin Sen Sen Ser Leu Sen Glu Met Sen 150 Lys Asp Ala 165 Sen Ser Ser 180 Leu Glu Asp Gly.
Leu Gin 55 Asn Lys Ser Asn Arg 135 Ala Alia Phe 40 Asp Glu Glu Glu Glu 120 Asp Leu Phe 25 Ile Tyr Val1 Val Arg 105 Ile Lys Gin 10 Ang Leu Val Val Lys His Leu Glu 75 Ala Pro 90 Asn Asp Val Lys Asn Leu Giu Val 155 Ala His Giu Ala Glu Ser G iu Ala Ala Leu 140 Asn Gin Glu Phe Lys Ser Lys Phe Phe Lys Phe Ile Ala Tyr Gin Thr Arg Glu Pro Asn Asn Ile Leu Tyr Asp Leu Asn Glu Phe Lys 110 Phe Ala Lys Tyr 125 Giu Lys Sen Pro Leu Leu Tyr Glu 160 Ser Leu Sen Thr 175 Val Leu Lys His 190 le Lys Lys 170 Leu Tyr Ala Ile 185 Ile Ile Sen INFORMATION FOR SEQ ID NO:806: SEQUENCE CHARACTERISTICS: LENGTH: 130 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...130 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:806 Met Asp Ala Leu Glu Ile Thr Gin Lys Leu Ile Ser Tyr Pro Thr Ile 1 5 10 Thr Pro Lys Glu Cys Gly Ile Phe Glu Tyr Ile Lys Ser Leu Phe Pro 25 Ala Phe Lys Thr Leu Glu Cys Glu Lys Asn Gly Val Lys Asn Leu Phe 40 Leu Tyr Arg Ile Phe Asn Pro Leu Lys Lys His Ala Glu Lys Glu His 55 Ala Lys Glu Lys His Val Lys Glu Asn Val Unk Pro Leu His Phe Cys 70 75 Unk Ala Gly His Ile Unk Val Val Pro Pro Gly Unk Unk Unk Unk Unk 90 Asp Ser Phe Unk Unk Ile Ile Lys Glu Gly Phe Leu Tyr Gly Arg Gly 100 105 110 Ala Gin Asp Met Lys Gly Gly Val Gly Unk Phe Unk Arg Cys Unk Unk 115 120 125 Lys Phe 130 e INFORMATION FOR SEQ ID NO:806: SEQUENCE CHARACTERISTICS: LENGTH: 130 amino acids TYPE: amino acid S* TOPOLOGY: linear (ii) MOLECULE TYPE: protein •(iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...130 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:806 Met Asp Ala Leu Glu Ile Thr Gin Lys Leu Ile Ser Tyr Pro Thr Ile 1 5 10 Thr Pro Lys Glu Cys Gly Ile Phe Glu Tyr Ile Lys Ser Leu Phe Pro 25 Ala Phe Lys Thr Leu Glu Cys Glu Lys Asn Gly Val Lys Asn Leu Phe 40 Leu Tyr Arg Ile Phe Asn Pro Leu Lys Lys His Ala Glu Lys Glu His 55 Ala Lys Glu Lys His Val Lys Glu Asn Val Unk Pro Leu His Phe Cys 70 75 670 Unk Ala Gly His Ile Unk Val Val Pro Pro Gly Unk Unk Unk Unk Unk 90 Asp Ser Phe Unk Unk Ile Ile Lys Glu Gly Phe Leu Tyr Gly Arg Gly 100 105 110 Ala Gin Asp Met Lys Gly Gly Val Gly Unk Phe Unk Arg Cys Unk Unk 115 120 125 Lys Phe 130 INFORMATION FOR SEQ ID NO:807: SEQUENCE CHARACTERISTICS: LENGTH: 101 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...101 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:807 Val His Phe Asn Gin Val Val Leu Pro Lys Gly Val Gly Ala Ile Leu 1 5 10 Val Ala Pro Lys Gly Pro Gly Ser Ala Leu Arg Glu Glu Tyr Leu Lys 25 Asn Arg Gly Leu Tyr His Leu Ile Ala Ile Glu Gin Glu Ser Ser Ile 35 40 His Asn Ala Lys Ala Val Ala Leu Ser Tyr Ala Lys Ala Met Gly Gly 55 Gly Arg Met Gly Val Leu Glu Thr Ser Phe Lys Glu Glu Cys Glu Ser 65 70 75 Asp Leu Phe Gly Glu Gin Ala Val Leu Cys Gly Gly Leu Glu Val Asp 90 Arg Lys Asn Gly Val 100 INFORMATION FOR SEQ ID NO:808: SEQUENCE CHARACTERISTICS: 99* LENGTH: 80 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...80 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:808 r I Met 1 Asn Gin Gin Lys Phe Phe Ser Gin Ser Leu Leu Ala 5 10 Val Ser Gly Met Asp Gly Asn Gly Val 25 Gin Gly Gin Ala Gin Met His Ala Asp 40 Thr Asn Ala Thr Ile Lys Gly Phe Asp Phe Phe Giu Lys His Phe Gly Leu Arg 70 75 Leu Ile Ile Ser Met Phe Leu Giy Ala Gly Ile Asn Ser Gin Lys Ala Leu Leu Gly Tyr Leu Tyr Gly Val Phe INFORMATION FOR SEQ ID NO:809: SEQUENCE CHARACTERISTICS: LENGTH: 447 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION 447 (xi) SEQUENCE DESCRIPTION: SEQ ID N0:809 .00.
a.
Met Val Lys Ile Phe 65 Ser Asn Arg Met Ile 145 Leu Gly Asp Leu Ang Leu Leu Val 130 Ile Arg Lys Lys Ile Phe Tyr Gly Phe Ile Val.Leu Phe Leu Leu Ile Asp Phe Leu Asp Thr 115 Leu Ser Tyr Leu Ala Arg TIyr Ala Ala 100 Giu Thr Ile Leu Ser 180 Ile Thr Ala Lys Lys Ala Val Val Gly Ang Arg *Asn 165 *Leu *Thr *Lys Val Ile Gly Arg 70 Giu Met Gly Giu Ile 150 Gin Gly Met Asn Leu Lys Arg 55 Phe Asp Ang Ser Lys 135 C11 u Thr Tyr Leu Leu Val Al~ 25 Asp Ty: 40 Leu Ii Giu G1 Thr Le Ala Me 10 Thr Le 120 Thr Le L y s V ahe P Phe L Val A] 200 Giu P1 a Gin Vai Trp t 5 .1 eS Arg Ala Ile Phe 90 Ile Thr Thr Leu Gly 170 Lys Leu Ser Unk Val 250 Pro Asn Pro 75 Phe Lys Gin Arg Ser 155 His Pro Sen Ile Pro Giu Asn Gin Lys 140 Lys Gly Val Val1 Tyn Arg His Ala Leu 125 Leu Giu Tyr Asp Thr Ala Asp Phe G ly Lys 110 Val Lys Glu Tyr Lys 190 Ile Thr Ser Lys Val G ly Sen
LYS
Giu Ile Gly 175 Leu Ile Asp Gln Giu Giu Ile Gly Asn Ala Leu 160 Val Thr Lys Thr Ala Leu Tlyr Ile 225 Lys Asp 210 Giu 195 Pro Pro Arg Ala Pro Sen Phe 205 215 Ser 220 Ser Arg Ser Leu Arg Arg Leu Tyr Ser Leu Gly 230 Ser Ala Leu Asn Glu Val Pro Ile Ala Asn Asp Asn Giu Leu 240 Thr Sen Thn 255 rS Tyr Asn Gin 245, Gin Asn Ile Ala Pro Tyr Vai Val Asp Giu Vai Leu Lys Gin Leu Asp 260 265 270 Gin Leu Asp Gly Leu Lys Thr Gin Gly Tyr Thr Ile Lys Leu Thr Ile 275 280 285 Asp Leu Asp Tyr Gin Arg Leu Ala Leu Glu Ser Leu Arg Phe Giy His 290 295 300 Gin Lys Ile Leu Glu Lys Ile Ala Lys Glu Lys Pro Lys Thr Asn Aia 305 310 315 320 Ser Asn Asp Lys Asp Giu Asp Asn Leu Asn Ala Ser Met Ile Val Thr 325 330 335 Giu Thr Ser Thr Giy Lys Ile Leu Ala Leu Val Giy Gly Ile Asp Tyr 340 34S 350 Lys Lys Ser Ala Phe Asn Arg Ala Thr Gin Ala Lys Arg Gin Phe Gly 355 360 365 Set Ala Ile Lys Pro Phe Val Tyr Gin Ile Ala Phe Asp Asn Gly Tyr 370 375 380 Ser Thr Thr Ser Lys Ile Pro Asp Thr Aia Arg Asn Phe Giu Asn Gly 385 390 395 400 Asn Tyr Ser Lys Asn Ser Val Gin Asn His Ala Trp His Pro Ser Asn 405 410 415 Tyr Unk Arg Lys Phe Leu Gly Leu Val Thr Leu Gin Glu Ala Leu Ser 420 425 430 His Set Leu Asn Leu Ala Thr Ile Asn Leu Ala Ile Ala Trp Leu 435 440 445 INFORMATION FOR SEQ ID NO:810: SEQUENCE CHARACTERISTICS: LENGTH: 218 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .218 (xi) SEQUENCE DESCRIPTION: SEQ ID Met Asn Asp Thr Thr Giu His His Gly Set Asn Pro Leu Asn Ala Pro 1 5 10 is *Pro Pro Ser Asn Ser Gin Sen Asn Asp Leu Leu Asn Leu Leu Asp Ser a *20 25 Leu Tyr Pro Lys Giy Ser Leu Gly Glu Gin Ang Phe His Giu Ala Leu 40 :::Lys Asn Gin Glu Giu Leu Lys Asn Ile Leu Ile Gli Ile Glu Lys Leu Pro Gin Giu Lys Ang Tyr Glu Leu Leu Met Gin Ile Gly Gin Ala Lys 70 75 Gin Ang Ile Met Giu Ala Tyr Ala His Set Phe Leu Gly Tyr Ile Gly 90 Gly Leu Glu His Leu Leu Gly Leu Cys Met Gly Gly Ile Phe Val Leu 100 105 110 Phe Ala Ile Tyr Phe Val Phe Leu Arg Thr Ser Lys Asn Thr Glu Leu 115 120 125 Val Giu Ser Leu Lys Thr Lys Leu Lys Leu Gin Tyr Phe Tyr Tyr Ala 130 135 140 Phe Gly Val Gly Ala Val Leu Phe Phe Giy Leu Giu Th Ile Arg Set 673 145 150 155 160 Ile Tyr Glu Leu Tyr Ile Leu Gly Ile Gly Ser Thr Asn Asp Lys Val 165 170 175 Leu Phe Val Leu Lys Asn Ile Cys Phe Ile Gly Met Gly Tyr Leu Ile 180 185 190 Tyr Lys Val Ile Lys Val Ile Gly Ile Lys Asn Phe Ile Asn Gly Leu 195 200 205 Phe Ala Ser Lys Lys Gin Gly Gly Ala Glu 210 215 INFORMATION FOR SEQ ID NO:811: SEQUENCE CHARACTERISTICS: LENGTH: 192 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...192 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:811 Met Met Asp Lys Val Gly Phe Lys Ser Gin Gly Ile Phe Val Met Asp 1 5 10 Ala Ser Lys Arg Asp Gly Arg Leu Asn Ala Tyr Phe Gly Gly Leu Gly 20 25 Lys Asn Lys Arg Val Val Leu Phe Asp Thr Leu Ile Ser Lys Val Gly 35 40 Thr Glu Unk Leu Leu Ala Ile Leu Gly His Glu Leu Gly His Phe Lys 50 55 *to. Asn Lys Asp Leu Leu Lys Asn Leu Gly Ile Met Gly Gly Leu Leu Ala 70 75 Leu Val Phe Ala Leu Ile Ala His Leu Pro Pro Leu Val Phe Glu Gly 85 90 Phe Asn Val Ser Gin Thr Pro Ala Ser Leu Ile Thr Ile Leu Leu Leu 100 105 110 S* Phe Leu Pro Val Phe Ser Phe Tyr Ala Met Pro Leu Ile Gly Phe Phe 115 120 125 Ser Arg Lys Asn Glu Tyr Asn Ala Asp Lys Phe Gly Ala Ser Leu Ser 130 135 140 Ser Lys Glu Thr Leu Ala Lys Ala Leu Val Ser Ile Val Asn Glu Asn 145 150 155 160 Lys Ala Phe Pro Tyr Ser His Pro Phe Tyr Val Phe Leu His Phe Thr S..165 170 175 His Pro Pro Leu Leu Glu Arg Leu Lys Ala Leu Asp Tyr Glu Ile Glu 180 185 190 INFORMATION FOR SEQ ID NO:812: SEQUENCE CHARACTERISTICS: LENGTH: 340 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein 674 (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...340 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:812 Met Ile Leu Ser Ile Glu Ser Ser Cys Asp Asp Ser Ser Leu Ala Leu 1 Thr Glu Arg Ser Gin Ala Arg Pro Ala 145 Ser Tyr Pro Leu Glu 225 Tyr Arg Ala Glu Asn 305 Arg Lys Arg Lys Leu Leu Pro Leu Gly Leu 130 Arg Phe Pro Asn Ala 210 Lys His Tyr Ser Phe 290 SAla Phe Asn Ile His His Asn Gly Ser His 115 Ser Asp Gly Gly Glu 195 Phe Asn Phe Phe Gin 275 Asp Ala Ile Phe Glu His Ala Lys Leu Leu 100 Val Val Tyr Glu Gly 180 Pro Ser Ala Gin Lys 260 Asn Cys Met Pro Glu 340 5 Asp Ser Glu Asp Ser Ser Tyr Leu Glu Ser 165 Pro Leu Phe His Ser 245 Ile SLeu Glu Ile Leu 325 Ala 3er Asn Phe 70 Val Leu Ser Leu Asp 150 Phe Ile Met Ser Asn 230 Ala Lys Ala Leu Gly 310 Glu Lys Tyr Leu 55 Ser Thr Asn Leu Val 135 Ile Asp Val Phe Gly 215 Leu Ala Arg Leu Val 295 Arg Lys SLys Leu Gly 40 Pro Lys Leu Leu Phe 120 Ser Lys Lys Glu Pro 200 Leu Asn Ile Pro Arg 280 Leu Ser Ala Ile 25 Gly Leu Ile Ile Pro 105 Ile Gly Ile Val Lys 185 Ile Lys Asp Glu Lys 265 Lys Ala Ser Asr 10 Ala Val Leu Lys Glu 90 Leu Asn Gly Val Ser 170 Leu Pro Asn Glu His 250 Ile Ala SPro SLeu Ile 330 His Val Leu Ala 75 Gly Ile Glu His Ala 155 Lys Ala Leu Ala Val 235 Leu Phe Phe Leu Glu 315 Ser Phe Pro Glu Ile Leu Leu Lys Ser 140 Thr Met Leu Lys *Val 220 Lys Ile Gly Glu SGlu 300 Ala Pro Lys Glu Arg Ala Met Glu Gin 125 Leu Ser Leu Asp Asn 205 Arg Gin Gin Ile Asp 285 Phe Tyr Arg Ile Ile Val Ile Met Asp 110 Thr Ile Leu Asp Tyr 190 Ser Leu Lys Gin Val 270 Leu Cys Gin Thr Ser Gin Ala Ser Lys Ile Thr Asn Ala Lys His Leu Arg Met Leu Glu Asp Asp 160 Leu Gly 175 Ala His Pro Asn Glu Val Ile Gly 240 Thr Lys 255 Gly Gly Cys Ala SSer Asp Lys Lys 320 Leu Leu 335 INFORMATION.FOR SEQ ID NO:812: SEQUENCE CHARACTERISTICS: LENGTH: 340 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .340 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:8i2 0*0.
so Met 1 Thr Glu Arg Ser Gln Ala .Arg Pro Ala 145 Sen Tyr Pro Leu Glu 225 Arg Ala Glu Asn 305 Arg Lys Ile Arg Lys Leu so Leu Pro Leu Gly Leu 130 Arg Phe Pro Asn Ala 210 Lys His Ser Phe 290 Ala Phe Asn Ile His His Asn Gly Ser His 115 Ser Asp Gly Gly Glu 195 Phe Asn Phe Phe Gin 275 Asp Ala Ile Phe Giu His Ala Lys T eU Leu 100 Val Val Giu dly 180 Pro Ser Ala Gin Lys 260 Asn Cys Met Pro Glu 5 Asp Ser Glu Asp Ser Ser Leu Glu Sen 165 Pro Leu Phe His Ser 245 Ile Leu 0 iu Ile Leu 325 Ala Sen As n Phe 70 Val1 Leu Ser Leu Asp 150 Phe Ile Met Ser Asn 230 Aia Lys Ala Leu 0 iy 310 Giu Lys Tyr Leu 55 Ser Thr Asn Leu Val 135 Ile Asp Val1 Phe Gly 215 Leu Aia Arg Leu Val 295 A~rg Lys Leu Gly 40 Pro Lys Leu Leu Phe 12 0 Ser Lys Lys G iu Pro 200 Leu As n Ile Pro Ang 280 Leu Ser Ala Ile 25 G ly Leu Ile Ile Pro 105 Ile G ly Ile Val Lys 185 Ile Lys Asp Giu Lys 265 Lys Aia S er Asp Ala Val1 Leu Lys Giu Leu As n Gly Vali Ser 170 Leu Pro Asn Glu His 250 Ile Ala Pro Leu Ile 330 His Phe Val Pro Leu Glu Ala Ile 75 Gly Leu Ile Leu Giu Lys His Sen 140 Ala Thr 155 Lys Met Ala Leu Leu Lys Ala Val 220 Val Lys 235 Leu Ile Phe Gly Phe Giu Leu Glu 300 Giu Ala 315 Ser Pro Lys Glu Arg Ala Met Glu Gin 125 Leu Sen Leu Asp As n 205 Arg Gin Gin Ile Asp 285 Phe Tyr Arg Ile Ile Val1 Ile Met Asp 110 Thr Ile Leu Asp Tyr 190 Ser Leu Lys Gin Val1 270 Leu Cys Gin Thr Ser Ala Lys Thr Ala His Arg Leu Asp Leu 175 Ala Pro Giu Ile Thr 255 Gly Cys Sen Lys Leu 335 Gin Sen Ile Asn Lys Leu Met Glu Asp 160 Gly His Asn Val1 G iy 240 Lys Gly Ala Asp Lys 320 Leu Leu Ser Ile Glu Sen Sen Cys Asp Asp Ser Ser Leu Ala Leu INFORMATION FOR SEQ ID NO:8i3: SEQUENCE CHARACTERISTICS: LENGTH: 201 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...201 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:813 Met Asn Ile Tyr Gin Lys Asn Leu Gin Ala Leu Phe Lys Lys Asp Pro 1 5 10 Leu Leu Phe Ala Lys Leu Lys Ala Ile Lys Glu Asn Lys Lys Tyr Glu 25 Val Phe Leu Gly Asn Asp Ser Ala Asn Phe Asn Leu Leu Asp Lys Glu 40 Thr Asn Thr Pro Leu Phe Glu Lys Ser Pro Leu Asp Ser Ser Leu Glu 55 Leu Tyr Lys Asn Ser Glu Ile His Met Leu Tyr Pro Tyr Leu Tyr Tyr 70 75 Phe Gly Leu Gly Asn Gly Val Phe Tyr Arg Leu Leu Leu Gly Asn Glu 90 Asn Leu Lys Arg Leu Val Val Ile Glu Pro Glu Ile Glu Val Ile Phe 100 105 110 Ile Val Leu Asn Leu Leu Asp Phe Ser Thr Glu Ile Leu Glu Asn Arg 115 120 125 Leu Ile Leu Leu His Ala Ser Phe Cys Asn Tyr Asn Met Ile Ala Ser 130 135 140 Leu Phe Asp Met Asp Lys Lys Ser Arg Leu Tyr Ala Arg Met Tyr Asp 145 150 155 160 Leu Lys Leu Phe Asn Ala Tyr Tyr Glu Arg Tyr Ser His Gin Met Ile 165 170 175 Glu Ile Asn Gin His Phe Thr Arg Ala Leu Glu His Gly Ala Ile Ser 180 185 190 Val Gly Asn Asp Ala Lys Ala His Ser 195 200 INFORMATION FOR SEQ ID NO:814: SEQUENCE CHARACTERISTICS: LENGTH: 130 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...130 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:814 Met Lys Lys Ile Ile Leu Ala Cys Leu Val Ala Phe Val Gly Ala Asn 1 5 10 Leu Ser Ala Glu Pro Lys Trp Tyr Ser Lys Ala Tyr Asn Lys Thr Asn 25 Ala Gin Lys Gly Tyr Leu Tyr Gly Ser Gly Ser Ala Thr Ser Lys Glu 40 Ala Ser Lys Gin Lys Ala Leu Ala Asp Leu Val Ala Ser Ile Ser Val 55 Val Val Asn Ser Gin Ile His Ile Gin Lys Ser Arg Val Asp Asn Lys 70 75 Leu Lys Ser Ser Asp Ser Gin Thr Ile Asn Leu Lys Thr Asp Asp Leu 90 Glu Leu Asn Asn Val Glu Ile Val Asn Gin Glu Ala Gin Lys Gly Ile 100 105 110 Tyr Tyr Thr Arg Val Arg Asn Gin Ser Lys Leu Val Phe Ala Gly Phe 115 120 125 Lys Gly 130 INFORMATION FOR SEQ ID NO:815: SEQUENCE CHARACTERISTICS: LENGTH: 144 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...144 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:815 o Met Lys Ile Gin Thr Ile Ser Thr Leu Val Leu Thr Ile Ile Met Val 1 5 10 Ile Gin Lys Met Ile Val Gly Lys Ile Ser Pro His Lys Thr Ala Glu 20 25 Glu Phe Thr Asn Leu Met Leu Asn Met Ile Ala Val Leu Asp Ser Gin 40 Ser Trp Gly Asp Ala Ile Leu Asn Ala Pro Phe Glu Phe Thr Asn Ser 50 55 Pro Thr Asp Cys Asp Asn Asp Pro Ser Lys Cys Val Asn Pro Gly Thr 70 75 Asn Gly Leu Val Asn SertLys Val Asp Gin Lys Tyr Val Leu Asn Lys 85 90 Gin Asp Ile Val Asn Lys Phe Lys Asn Lys Ala Asp Leu Asp Val Ile 100 105 110 Val Leu Lys Asp Ser Gly Val Val Gly Unk Unk Asn Gly Tyr Gly Asn 115 120 125 Asp Gly Glu Tyr Gly Thr Leu Gly Val Unk Ala Tyr Ala Leu Gly Ser 130 135 140 INFORMATION FOR SEQ ID NO:816: SEQUENCE CHARACTERISTICS: LENGTH: 309 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1...309 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:816 Val Ile Glu Gin Cys Leu Thr Leu Ile Gly 145 Giu Thr Ser Arg Val 225
LYS
Leu Asn Asn Gin 305 Val Ile Arg Leu Val Leu Asn Met Leu Thr Cys Gin Ile Ser Axg Arg Ala Ile Leu Phe Gly Ala 130 Ile Ile Sen Val1 Ile 210 His Asn Asn Val Arg 290 Asp Ile Phe Lys Giy Sen Ile Val 115 Val Ile Ser Leu Ala 195 Glu
LYS
Met Phe Arg 275 Ile Ser Ser Met His Phe Lys Leu 100 Gin Ala Leu Gly Arg 180 As n Trp Thr Pro Thr 260 Ser G iu Ser Tyr Asp Phe Tyr Lys Ile Thr Leu Ile Leu 165 Leu Ser Val1 Ile Thr 245 Ile Giu Ile Lys Leu Giu Gly Phe 70 Asp Leu Thr Ala Ile 150 Glu His Asn Cys Lys 230 Phe Axg Leu Pro Phe Val1 Ala Asn Phe Ile Leu Ser 140 Lys Leu Val Asn Sen 220 Met Phe Giu Asri Ile 300 Vali Asp Ile Lys Val Ala Gly 125 Ser Gly Asn Leu Thr 205 Asp G iu 0 iy Asp Ala 285 Sen Ile Phe Val1 Thr Ala Leu 110 Thr Ile Asp Phe Pro 190 Ala Ile Lys Gin Giy 270 Leu Ile Tyr Lys Pro Phe Lys Vai Thr Gly Gly Ile 160 Asn Arg Arg Leu Asp 240 Ser Phe Ala Lys a. '0.
se INFORMATION FOR SEQ ID NO:817: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 164 amino acids TYPE: amino acid TOPOLOGY: linear (i)MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...164 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:817 Met Lys Asn Phe Ser Pro Leu Tyr Cys Leu Lys Unk Leu Lys Lys Arg 1 5 10 His Leu Ile Ala Leu Ser Leu Pro Leu Leu Ser Tyr Ala Asn Gly Phe 25 Lys Ile Gin Glu Gin Ser Leu Asn Gly Thr Ala Leu Gly Ser Ala Tyr 40 Val Ala Gly Ala Arg Gly Ala Asp Ala Ser Phe Tyr Asn Pro Ala Asn 55 Met Gly Phe Thr Asn Asp Trp Gly Glu Asn Arg Ser Glu Phe Glu Met 70 75 Thr Thr Thr Val Ile Asn Ile Pro Thr Phe Ser Phe Lys Val Pro Thr 90 Thr Asn Gin Unk Leu Tyr Ser Val Thr Ser Leu Glu Ile Asp Lys Ser 00o 105 110 Gin Gin Asn Ile Leu Gly Ile Ile Asn Thr Ile Gly Leu Gly Asn Ile 115 120 125 Leu Lys Ala Leu Gly Asn Thr Ala Ala Thr Asn Gly Leu Ser Gin Ala 130 135 140 Ile Asn Arg Val Gin Gly Leu Met Asn Leu Thr Asn Gin Lys Val Val 145 150 155 160 Thr Leu Ala Ser INFORMATION FOR SEQ ID NO:818: SEQUENCE CHARACTERISTICS: LENGTH: 54 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES 4 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...54 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:818 Met Cys Leu Ala Ile Pro Ser Lys Val Ile Ala Ile Asn Asp Asn Val 1 5 10 Ala Leu Leu Glu Thr Leu Gly Val Gln Arg Glu Ala Ser Leu Asp Leu 25 Met Gly Glu Ser Val Lys Val Gly Asp Tyr Val Leu Leu His Ile Gly 40 Tyr Val Met Ser Lys Asp INFORMATION FOR SEQ ID NO:819: 680 SEQUENCE CHARACTERISTICS: LENGTH: 202 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...202 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:819 Met Lys Tyr Leu Trp Leu Phe Leu Ile Tyr Ala Ile Gly Leu Phe Ala 1 5 10 Thr Asp Lys Thr Leu Asp Ile Ile Lys Thr Ile Gin Lys Leu Pro Lys 25 Ile Glu Val Arg Tyr Ser Ile Asp Asn Asp Ala Asn Tyr Ala Leu Lys 40 Leu His Glu Val Leu Ala Asn Asp Leu Lys Thr Ser Gin His Phe Asp 55 Val Ser Gin Asn Lys Glu Gin Gly Ala Ile Asn Tyr Ala Glu Leu Lys 70 75 Asp Lys Lys Val His Leu Val Ala Leu Val Ser Val Ala Val Glu Asn 90 Gly Asn Lys Hle Ser Arg Leu Lys Leu Tyr Asp Val Asp Thr Gly Thr 100 105 110 Leu Lys Lys Thr Phe Asp Tyr Pro Ile Val Ser Leu Asp Leu Tyr Pro S* 115 120 125 Phe Ala Ala His Asn Met Ala Ile Val Val Asn Asp Tyr Leu Lys Ala 130 135 140 Pro Ser Ile Ala Trp Met Lys Arg Leu Ile Val Phe Ser Lys Tyr Ile 145 150 155 160 0. Gly Pro Gly Ile Thr Asn Ile Ala Leu Ala Asn Tyr Thr Met Arg Tyr S 165 170 175 Gln Lys Glu Ile Ile Lys Asn Asn Arg Leu Asn Ile Phe Pro Lys Trp 180 185 190 Ala Asn Ala Glu Gin Thr Glu Phe Tyr Tyr 195 200 INFORMATION FOR SEQ ID NO:820: SEQUENCE CHARACTERISTICS: LENGTH: 168 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...168 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:820 Met Leu Ser Ser Asn Asp Leu Phe Met Val Val Leu Gly Ala Ile Leu 1 5 10 Leu Val Leu Val Cys Leu Val Gly Tyr Leu Tyr Leu Lys Glu Lys Giu 25 Phe Tyr His Lys Met Arg Arg Leu Giu Lys Thr Leu Asp Giu Ser Tyr 40 Gin Giu Asn Tyr Leu Tyr Ser Lys Arg Leu Arg Giu Leu Giu Giy Arg 55 Leu Giu Gly Leu Ser Leu Glu Lys Ser Ala Lys Giu Asp Ser Ser Leu 70 75 Lys Thr Thr Leu Ser His Leu Tyr Asn Gin Leu Gin Giu Ile Gin Lys 90 Ser Met Asp Lys Giu Arg Asp Tyr Leu Glu Giu Lys Ile Ile Unk Unk 100 105 110 Lys Thr Unk Unk Lys Thr Trp Gly Ile Met Pro Leu Ala Met Lys Ser 115 120 125 Thr Giu Lys Gin Val Leu Lys Met Tyr Gin Glu Gly Tyr Ser Val Asp 130 135 140 Ser Ile Ser Lys Giu Phe Lys Val Ser Lys Giy Giu Val Giu Phe Ile 145 150 155 160 Leu Asn Met Ala Gly Leu Lys Trp 165 INFORMATION FOR SEQ ID NO:820: SEQUENCE CHARACTERISTICS: LENGTH: 168 amino acids iB) TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-.feature LOCATION .168 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:820 Met Leu Ser Sen Asn Asp Leu Phe Met Val Val Leu Gly Ala Ile Leu 1 5 10 1 Leu Val Leu Val Cys Leu Val Gly Tyr Leu Tyn Leu Lys Giu Lys Glu 25 Phe Tyr His Lys Met Ang Ang Leu Giu Lys Thn Leu Asp Giu Ser Tyr 40 Gin Glii Asn Ty-r Leu Tyr Ser Lys Arg Leu Arg Giu Leu Giu Gly Ang 55 Leu Glu Gly Leu Sen Leu Giu Lys Ser Ala Lys Giu Asp Ser Ser Leu 70 75 Lys Thr Thr Leu Sen His Leu Tyr Asn Gin Leu Gin Glu Ile Gin Lys 90 Ser Met Asp Lys Giu Arg Asp Tyr Leu Glu Giu Lys Ile Ile Unk Unk 100 105 110 Lys Tbr Unk Unk Lys Thn Trp Gly Ile Met Pro Leu Ala Met Lys Ser 115 120 125 Thr Giu Lys Gin Val Leu Lys Met Tyr Gin Giu Gly Tyr Sen Val Asp 130 135 140 Sen Ile Ser Lys Giu Phe Lys Val Sen Lys Gly Glu Val Glu Phe Ile 145 150 155 160 Leu Asn Met Ala Gly Leu Lys Trp 165 INFORMATION FOR SEQ ID NO:821: SEQUENCE CHARACTERISTICS: LENGTH: 186 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...186 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:821 Val Val Ser Gly Val Val Ile Ile Ile Val Phe Phe Val Pro Ile Leu 1 5 10 Thr Leu Gln Gly Leu Glu Gly Lys Met Phe Arg Pro Leu Ala Gin Ser 25 lie Val Tyr Ala Leu Leu Gly Thr Leu Val Leu Ser Ile Thr Ile Ile 35 40 SPro Val Val Ser Ser Leu Val Leu Lys Ala Thr Pro His Ser Glu Thr 50 55 Phe Leu Thr Arg Phe Leu Asn Arg Ile Tyr Ala Pro Leu Leu Glu Phe 65 70 75 Phe Val His Asn Pro Lys Lys Val Ile Leu Gly Ala Phe Val Phe Leu 90 Ile Ala Ser Leu Ser Leu Phe Pro Phe Val Gly Lys Asn Phe Met Pro 100 105 110 Ala Leu Asp Glu Gly Asp Val Val Leu Ser Val.Glu Thr Thr Pro Ser 115 120 125 Ile Ser Leu Asp Gin Ser Lys Asp Leu Met Leu Asn Ile Glu Ser Ala 130 135 140 Ile Lys Lys His Val Lys Glu Val Lys Ser Ile Val Ala Arg Thr Gly 145 150 155 160 Ser Asp Glu Leu Gly Leu Asp Leu Gly Gly Leu Asn Gln Thr Asp Thr 165 170 175 Phe Ile Ser Phe Ile Pro Lys Lys Glu Trp 180 185 INFORMATION FOR SEQ ID NO:822: SEQUENCE CHARACTERISTICS: LENGTH: 72 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...72 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:822 Val Gly Tyr Ile Pro Unk Glu Lys Ile Val Gly Ile Ser Ala Ile Ala 1 5 10 Lys Leu Ile Glu Ile Tyr Ser Lys Arg Leu Gin Ile Gln Glu Arg Leu 25 Thr Thr Gin Ile Ala Glu Thr Phe Asp Glu Ile Ile Glu Pro Arg Gly 40 Val Ile Val Val Cys Glu Ala Lys Pro Leu Val His Glu His Ala Arg 55 Gly Ala Lys Ala Lys Cys Asp His INFORMATION FOR SEQ ID NO:823: SEQUENCE CHARACTERISTICS: LENGTH: 121 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...121 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:823 Leu Asp Pro Phe Ser His Lys Glu Asn Phe Leu Ala Val Glu Thr Phe 1 5 10 Lys Met Leu Gly Lys Thr Glu Ser Lys Asp Asn.Leu Asn Trp Met Ile 25 Ala Leu Ile Ile Glu Lys Asp Lys Val Tyr Glu Gin Val Gly Ser Val 35 40 Arg Phe Val Val Val Val Ala Ser Ala Ile Met Val Leu Ala Leu Ile 50 55 Ile Ala Ile Thr Leu Leu Met Arg Ala Ile Val Ser Asn Arg Leu Glu 70 75 6. Val Val Ser Ser Thr Leu Ser His Phe Phe Lys Leu Leu Asn Asn Gin 90 Unk His Ser Ser Unk Unk Lys Leu Val Unk Ala Arg Ser Asn Asp Glu 100 105 110 Leu Gly Arg Unk Gin Thr Unk Asp Unk 115 120 INFORMATION FOR SEQ ID NO:823: SEQUENCE CHARACTERISTICS: LENGTH: 121 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...121 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:823 Leu Asp Pro Phe Ser His Lys Glu Asn Phe Leu Ala Val Glu Thr Phe 1 5 10 Lys Met Leu Gly Lys Thr Glu Ser Lys Asp Asn Leu Asn Trp Met Ile 25 Ala Leu Ile Ile Glu Lys Asp Lys Val Tyr Glu Gin Val Gly Ser Val 40 Arg Phe Val Val Val Val Ala Ser Ala Ile Met Val Leu Ala Leu Ile 55 Ile Ala Ile Thr Leu Leu Met Arg Ala Ile Val Ser Asn Arg Leu Glu 70 75 Val Val Ser Ser Thr Leu Ser His Phe Phe Lys Leu Leu Asn Asn Gin 90 Unk His Ser Ser Unk Unk Lys Leu Val Unk Ala Arg Ser Asn Asp Glu 100 105 110 Leu Gly Arg Unk Gin Thr Unk Asp Unk 115 120 INFORMATION FOR SEQ ID NO:824: SEQUENCE CHARACTERISTICS: LENGTH: 13 amino acids oo TYPE: amino acid S* TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...13 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:824 Val Ala Leu Val Phe Asp Ser Leu Ile Glu Asn Lys Lys 1 5 INFORMATION FOR SEQ-ID NO:825: SEQUENCE CHARACTERISTICS: LENGTH: 99 amino acids TYPE: amino acid TOPOLOGY: linear (ii) .MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...99 (xi) SEQUENCE DESCRIPTION: SEQ ID N0:825 Met Lys Lys Ile Gly Leu Ser Leu Cys Leu Val Leu Ser Leu Gly Phe 1 5 10 Leu Lys Ala His Glu Val Ser Ala Glu Glu Ile Ala Asp Ile Phe Tyr 25 Lys Leu Asn Ala Lys Glu Pro Lys Met Lys Ile Asn His Thr Lys Gly 40 Phe Cys Ala Lys Gly Val Phe Leu Pro Asn Pro Gin Ala Arg Glu Asp 55 Leu Glu Val Pro Leu Leu Asn Glu Lys Glu Ile Pro Ala Ser Val Arg 70 75 Tyr Ser Leu Gly Gly Val Val Asp Trp Thr Ile Lys Ala Arg Leu Gly 90 Glu Trp Arg INFORMATION FOR SEQ ID NO:826: SEQUENCE CHARACTERISTICS: LENGTH: 71 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...71 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:826 S Val Ile Lys Pro His Ser Val Gly Leu Val Arg Ile Gly Ile Cys Leu 1 5 10 Ser Leu Glu Val Gly Tyr Glu Leu Gin Val Arg Thr Arg Ser Gly Leu 20 25 SAla Leu Asn His Gin Val Met Val Leu Asn Unk Pro Gly Thr Val Asp 40 Asn Asp Tyr Arg Gly Glu Ile Lys Val Ile Leu Ala Asn Leu Ser Asp 55 Lys Asp Phe Lys Val Gin Val INFORMATION FOR SEQ ID NO:827: SEQUENCE CHARACTERISTICS: LENGTH: 149 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...149 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:827 Met Glu Phe Tyr Gin Val Tyr Asp Pro Leu Gly His Ile Trp Leu Ser 1 5 10 Ala Leu Val Ala Leu Ser Pro Ile Ala Leu Phe Phe Ile Ser Leu Ile 25 Val Phe Lys Leu Lys Gly Tyr Ser Ala Gly Phe Leu Ser Leu Ala Leu 40 Ser Ile Leu Ile Ala Leu Phe Val Tyr Lys Met Pro Val Gin Met Val 55 Ser Ala Ser Phe Phe Tyr Gly Phe Leu Tyr Gly Leu Trp Pro Ile Ala 70 75 Trp Ile Val Ile Ala Ala Ile Phe Leu Tyr Asn Leu Ser Val Lys Ser 90 Gly Tyr Phe Glu Ile Leu Lys Glu Ser Ile Leu Ser Leu Thr Pro Asp 100 105 110 His Arg Ile Leu Val Ile Leu Ile Gly Phe Cys Phe Gly Ser Phe Leu **115 120 125 Unk Gly Ala Unk Gly Phe Gly Gly Pro Val Ala Ile Thr Ala Ala Ile 130 135 140 Leu Val Ala Leu Gly 145 INFORMATION FOR SEQ ID NO:827: SEQUENCE CHARACTERISTICS: LENGTH: 149 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori o (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...149 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:827 Met Glu Phe Tyr Gin Val Tyr Asp Pro Leu Gly His Ile Trp Leu Ser 1 5 10 Ala Leu Val Ala Leu Ser Pro Ile Ala Leu Phe Phe Ile Ser Leu Ile 25 Val Phe Lys Leu Lys Gly Tyr Ser Ala Gly Phe Leu Ser Leu Ala Leu 40 Ser Ile Leu Ile Ala Leu Phe Val Tyr Lys Met Pro Val Gin Met Val 55 Ser Ala Ser Phe Phe Tyr Gly Phe Leu Tyr Gly Leu Trp Pro Ile Ala 70 75 Trp Ile Val Ile Ala Ala Ile Phe Leu Tyr Asn Leu Ser Val Lys Ser 90 Gly Tyr Phe Glu Ile Leu Lys Glu Ser Ile Leu Ser Leu Thr Pro Asp His Unk Leu 145 100 105 110 Arg Ile Leu Val Ile Leu Ile Gly Phe Cys Phe Gly Ser Phe Leu 115 120 125 Gly Ala Unk Gly Phe Gly Gly Pro Val Ala Ile Thr Ala Ala Ile 130 135 140 Val Ala Leu Gly INFORMATION FOR SEQ ID NO:828: SEQUENCE CHARACTERISTICS: LENGTH: 255 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHIETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .255 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:828 Met Glu Ile Ile Leu Leu Ile Val Ala Ala Val Val Leu Phe a a a a. 1 Tyr Lys Ser Arg Leu Gin Giu Giu Tyr 145 Val Asp Giu Leu Asn 225 Ile Asn Thr Ser 50 Leu Arg Gin Asn Tyn 130 Ala Gly Asn Ala Glu 210 Asp Ala Thr G iu Pro Leu Thr Asn Phe 115 Thr Asp Ala Phe Lys 195 Lys Asn Leu ta a a a 5 Leu Lys 20 Giu Tyr Leu Asp Lys Phe Leu Phe Leu Ala 100 Glu Sen Lys Ang Gly Ile Phe Leu 165 Giu His 180 Asn Leu Lys Ala Lys Ang Ala Sen 245 Glu Asp Lys Leu 70 Ile Lys Leu Leu Leu 150 Gin Phe Phe Leu Tyr 230 Gin Tyn Leu Phe 55 Asp His Giu Cys Lys 135 Asp Ile Asn Glu Asp 215 Sen Leu Leu Lys 40 Lys Ile Glu Leu Gin 120 Leu Sen Asp Sen Ile 200 Leu Glu Lys 25 Asn Gin Gin Leu Leu 105 Giu Val Lys Asn Ile 185 Gin Ser Gin 10 Asn Asp Thr Lys Giu 90 Asn Ile Glu Giu Gin 170 Giu Thr Ala Asp Pro Leu Pro Tyr Gin Ile Asn Ala 75 Gin Pro Giu Pro Ala Asp Phe Leu 140 Lys Giu 155 Asp Phe Ile Pro His Thr Pro Tyr 220 Phe Ile 235 Asn Leu Gly Leu Leu Val His 125 Met Leu Asn Met Thr 205 Tyr Ser Pro Leu Ala Asp Asn Asp 110 Thr Leu Phe Giu Ser 190 Met His Leu Tyr Phe Lys Thr Val Gin Tyr Met Asn Ala Sen Giu Lys Lys His Gly Leu Ala Leu Asp 160 Leu Tyn 175 Leu Giu Gin Asp Lys Met Lys Lys 240 Leu Giu Asn Asp Leu Lys Asp Ser INFORMATION~ FOR SEQ ID NO:829: SEQUENCE CHARACTERISTICS: LENGTH: 106 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...106 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:829 Met Glu Val Glu His Gly Lys Ile Glu Thr Thr Leu Ser Leu Gly Ala 1 5 10 Ser His Leu Glu Val Ile Lys Met Met Leu Leu Glu Ser Leu Pro Ser 25 Leu Val Asn Asn Ile Thr Ile Thr Leu Ile Ser Leu Ile Gly Tyr Ser 40 Ala Lys Ala Gly Ala Leu Gly Ala Gly Gly Leu Gly Asp Leu Ala Ile 55 Arg Ile Gly Tyr Gin Ser Tyr Arg Gly Asp Val Leu Phe Tyr Ala Val 70 75 Val Val Ile Ile Val Leu Val Gln Ile Ile Gin Ser Ala Gly Asp Tyr 85 90 Val Val Lys Arg Leu Arg Lys Asn Lys Tyr 100 105 9 INFORMATION FOR SEQ ID NO:830: SEQUENCE CHARACTERISTICS: LENGTH: 527 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...527 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:830 Met Asn Glu Ile Asp Lys Ser Val Asp Ile Gly Phe Leu Arg Ile Leu 1 5 10 Asp Val Ile Lys Lys Val Lys Thr Pro Lys Gly Gly Ile Glu Val Leu 25 Arg Thr Leu Ile Asp Phe Thr Pro Lys Ile Glu Asn Ala Leu Asn Leu 40 Ala Thr Lys Ser His Lys Gly Gin Tyr Arg Lys Ser Gly Glu Pro Tyr 55 Ile Val His Pro Ile Cys Val Ala Ser Val Val Ala Phe Cys Gly Gly 70 75 Asp Glu Ala Met Val Cys Ala Ala Leu Leu His Asp Val Val Glu Asp 689 90 Thr Pro Cys Giu Ile Giu Thr Ile Glu Arg Glu Phe Giy Gin Asp Vai 100 105 110 Ala Asn Leu Val Asp Aia Leu Thr Lys Ile Thr Giu Ile Arg Lys Giu 115 120 125 Glu Leu Gly Vai Ser Ser Gin Asp Pro Arg Met Val Val Ser Ala Leu 130 135 140 Thr Phe Arg Lys Ile Leu Ile Ser Ala Ile Gin Asp Pro Arg Ala Leu 145 iso 155 160 Val Val Lys Ile Ser Asp Arg Leu His Asn Met Leu Thr Leu Asp Ala 165 170 175, Leu Pro His Asp Lys Gin Val Arg Ile Ser Lys Giu Thr Leu Ala Val 180 -185 190 Tyr Ala Pro Ile Ala Ser Arg Leu Gly Met Ser Ser Ile Lys Asn Giu 195 200 205 Leu Giu Asp Lys Ser Phe Tyr Tyr Ile Tyr Pro Giu Giu Tyr Lys Asn 210 215 220 Ile Lys Glu Tyr Leu His Lys Asn Lys Gin Ser Leu Leu Leu Lys Leu 225 230 235 240 Asn Ala Phe Ala Ser Lys Leu Glu Lys Lys Leu Phe Asp Ser Gly Phe 245 250 255 Ser His Ser Asp Phe Lys Leu Val Thr Arg Val Lys Arg Pro Tyr Ser 260 265 270 Ile Tyr Leu Lys Met Gin Arg Lys Gly Ala Val Asn Ile Asp Giu Ile 275 280 285 Leu Asp Leu Leu Ala Ile Arg Ile Leu Leu Lys Asn Pro Ile Asp Cys 290 295 300 Tyr Lys Val Leu Gly Ile Ile His Leu Asn Phe Lys Pro Ile Val Ser 305 310 315 320 Arg Phe Lys Asp Tyr Ile Ala Leu Pro Lys Glu Asn Gly Tyr Lys Thr 325 330 335 Ile His Thr Thr Ile Phe Asp Glu Ser Ser Val Tyr Giu Val Gln Ile 340 345 350 Arg Thr Phe Asp Met His Met Gly Ala Giu Tyr Gly Asn Ser Ala His 355 360 365 Trp Lys Tyr Lys Ala Gly Gly Val Asp His Glu Glu His His Giu Gly 37037538 Met AgTrp Leu Gin Asn PeLys Tyr His Asp SrAsp Leu Lys Asn 385 390 39540 *Asp Pro Lys Giu Phe Tyr Giu Leu Ala Lys Asn*Asp Leu TLyr Arg Giu :..405 410 415 *Asp Ile Val Val Phe Ser Pro His Gly Asp Thr T1yr Thr Leu Pro Val 420 425 430 999 Gly Ala Ile Ala Leu Asp Phe Ala Tyr Met Val His Ser Asp Leu Gly 435 440 445 Asp Lys Ala Thr Asp Ala Tyr Ile Asn Ser Lys Lys Ala Leu Leu Asn 450 455 460 Gin Glu Leu Arg Ser Gly Asp Val Val Lys Ile Ile Lys Gly Asp Lys 465 470 475 480 *Val Ile Pro Arg Phe Ile Trp Met Asp Gin Leu Lys Thr Ser Lys Ala 485 490 495 Lys Asn His Leu Arg Ile Gin Arg Arg Asn Arg Leu Lys Giu Ile Asp 500 505 510 Thr Lys Ser Met Ile Asn Ile Leu Ala Thr Phe Phe Trp Ala Leu INFORMATION FOR SEQ ID NO:83i: SEQUENCE CHARACTERISTICS: LENGTH: 124 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc feature LOCATION .124 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:831 Val Val Val Val Giu Asn Ile Lys Asp Ala Val Pro Leu Ala Gin Ser 1 5 10 Leu Ile Unk Gly Gly Ile Pro Ile Ile Giu Val Thr Leu Arg Ser Asn 25 Cys Ala Leu Glu Ala Ile Giu Leu Ile Ala Lys Asn Val Pro Lys Met 40 Arg Val Gly Ala Gly Thr Ile Leu Asn Leu Thr Gin Leu Glu Gin Ala 55 Gin Asn Arg Gly Ala Glu Phe Leu Ile Ser Pro Gly Leu Thr Ile Lys 70 75 Leu Leu Glu His Ala Lys Lys Lys Asp Met Pro Leu Ile Pro Gly Val 90 Ser Ser Ser Ser Giu Val Met Gin Ala Leu Glu Leu Gly Ty'r Asn Ala 100 105 110 Leu Lys Phe Phe Pro Ala Giu Tyr Cys Gly Gly Arg 115 120 INFORMATION FOR SEQ ID NO:832: SEQUENCE CHARACTERISTICS: LENGTH: 110 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc feature LOCATION .110 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:832 Val Giu Lys Ile Lys Pro Tyr Ala Pro Lys Asp Ser Pro Leu Ile Asp 1 5 10 Tyr Ser Ser Leu Val Arg Asn Val Gin Ser Thr Leu Lys Gly Thr Sen 20 25 Phe Giu Thr Leu Ile Asn Gly Val Trp Glu Ser Phe Giu Thr Lys Val 40 Leu Gly Giu Phe Asn Ala Tyr Asn Ile Ala Ser Ala Ile Leu Thr Ala s0 55 Lys His Leu Gly Leu Glu Thn Giu Arg Ile Lys Arg Leu Val Phe Giu 70 75 Leu Lys Pro Ile Asn His Arg Leu Gin Leu Leu Glu Ala Asn Gin Lys 90 Ile Ile Ile Asp Asp Asn Phe Asn Gly Asn Leu Lys Gly Met 100 105 110 INFORMATION FOR SEQ ID NO:833: SEQUENCE CHARACTERISTICS: LENGTH: 325 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...325 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:833 Met Lys Arg Ile Leu Val Ser Leu Ala Val Leu Ser His Ser Ala His 1 5 10 Ala Val Lys Thr His Asn Leu Glu Arg Val Glu Ala Ser Gly Val Ala 25 Asn Asp Lys Glu Ala Pro Leu Ser Trp Arg Ser Lys Glu Val Arg Asn 40 Tyr Met Gly Ser Arg Thr Val Ile Ser Asn Lys Gln Leu Thr Lys Ser 55 Ala Asn Gin Ser Ile Glu Glu Ala Leu Gin Asn Val Pro Gly Val His 70 75 Ile Arg Asn Ser Thr Gly Ile Gly Ala Val Pro Ser Ile Ser Ile Arg 90 Gly Phe Gly Ala Gly Gly Pro Gly His Ser Asn Thr Gly Met Ile Leu 100 105 110 Val Asn Gly Ile Pro Ile Tyr Val Ala Pro Tyr Val Glu Ile Gly Thr 115 120 125 SVal Ile Phe Pro Val Thr Phe Gin Ser Val Asp Arg Ile Ser Val Thr 130 135 140 Lys Gly Gly Glu Ser Val Arg Tyr Gly Pro Asn Ala Phe Gly Gly Val 145 150 155 160 Ile Asn Ile Ile Thr Lys Gly Ile Pro Thr Asn Trp Glu Ser Gin Val 165 170 175 Ser Glu Arg Thr Thr Phe Trp Gly Lys Ser Glu Asn Gly Gly Phe Phe 180 185 190 Asn Gin Asn Ser Lys Asn Ile Asp Lys Ser Leu.Val Asn Asn Met Leu 195 200 205 Phe Asn Thr Tyr Leu Arg Thr Gly Gly Met Met Asn Lys His Phe Gly 210 215 220 Ile Gin Ala Gin Val Asn Trp Leu Lys Gly Gin Gly Phe Arg Tyr Asn 225 230 235 240 Ser Pro Thr Asp Ile Gin Asn Tyr Met Leu Asp Ser Leu Tyr Gin Ile 245 250 255 Asn Asp Ser Asn Lys Ile Thr Ala Phe Phe Gin Tyr Tyr Ser Tyr Phe 260 265 270 Leu Thr Asp Pro Gly Ser Leu Gly Ile Ala Ala Tyr Asn Gin Asn Arg 275 280 285 Phe Gin Asn Asn Arg Pro Asn Asn Asp Lys Ser Gly Arg Ala Lys Arg 290 295 300 Trp Gly Ala Val Tyr Gin Asn Phe Phe Gly Asp Thr Asp Arg Val Gly 305 310 315 320 Gly Gly Phe His Phe 325 692 INFORMATION FOR SEQ ID NO:833: SEQUENCE CHARACTERISTICS: LENGTH: 325 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori.
(ix) FEATURE: NAME/KEY: misc-feature LOCATION .325 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:833 Met Lys Arg Ile Leu Val Ser Leu Ala Val Leu Ser His Ser Ala His 1 5 10 Ala Val Lys Thr His Asn Leu Giu Arg Val Glu Ala Ser Gly Val Ala 25 Asn Asp Lys Glu Ala Pro Leu Ser Trp Arg Ser Lys Giu Val Arg Asn 40 Tyr Met Gly Ser Arg Thr Val Ile Ser Asn Lys Gin Leu Thr Lys Ser 55 Ala Asn Gin Ser Ile Giu Giu Ala Leu Gin Asn Val Pro Gly Vai His 70 75 Ile Arg Asn Ser Thr Gly Ile Gly Ala Vai Pro Ser Ile Ser Ile Arg 90 Gly Phe Gly Ala Gly Gly Pro Gly His Ser Asn Thr Gly Met Ile Leu 100 105 110 Val Asn Gly Ile Pro Ile Tyr Val Ala Pro Tyr Val Giu Ile Gly Thr 115 120 125 Val Ile Phe Pro Vai Thr Phe Gin Ser Val Asp Arg Ile Ser Val Thr 130 135 140 *Lys Gly Gly Giu Ser Val Arg Tyr Gly Pro Asrv Ala Phe Gly Gly Val *145 150 155 160 Ile Asn Ile Ile Thr Lys Gly Ile Pro Thr Asn Trp Giu Ser Gin Val 165 170 175 Ser Glu Arg Thr Thr Phe Trp Gly Lys Ser Giu Asn Gly Giy Phe Phe IS18 185 190 *Asn Gin Asn Ser Lys Asn Ile Asp Lys Ser Leu Val Asn Asn Met Leu 195 200 205 Phe Asn Thr T~yr Leu Arg Thr Gly Gly Met Met Asn Lys His Phe Gly 210 215 220 Sle Gin Ala Gin Val Asn Trp Leu Lys Gly Gin Gly Phe Arg Tyr Asn 225 230 235 240 Ser Pro Thr Asp Ile Gin Asn Tyr Met Leu Asp Ser Leu Tyr Gin Ile 245 250 255 Asn Asp Ser Asn Lys 'lie Thr Ala Phe Phe Gin Tyr T~yr Ser Tyr Phe *260 265 270 Leu Tbr Asp Pro Giy Ser Leu Gly Ile Ala Ala Tyr Asn Gin Asn Arg 275 280 285 Phe Gin Asn Asn Arg Pro Asn Asn Asp Lys Ser Gly Arg Ala Lys Arg 290 295 300 Trp Gly Ala Val Tyr Gin Asn Phe Phe Gly Asp Thr Asp Arg Val Gly 305 310 315 320 Gly Gly Phe His Phe 325 I1NFORMATION FOR SEQ ID NO:834: SEQUENCE CHARACTERISTICS: LENGTH: 252 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 252 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:834 ~0 Leu Asn Ile Asn As n Lys Leu Giu Val.
Ser 145 Gly Ty~r
LYS
Phe Unk 225 Arg Arg Ala Leu Ala Gly Thr Gin Giu Gly 130 Leu Ile Anrg Unk Asn 210 Asp Leu Leu Met Ser Gly Leu Lys Lys 115 Ser Sen Asp Leu Lys 195 Gin Leu Arg Asp Giu Leu Asp Val Giu 100 Asn Ala Gin Ser Sen 180 Unk Ile
LYS
Ala Lys Asn Gly Gly Phe Ang Giu Phe
LYS
Lys 165 Ala Tyr Leu Cys 245 Arg Ala Ala Tyr 70 Glu Ala Asp Lys Ala 150 Gly Trp Ile Giu Pro 230 Ala Giu 25 Ala Ile Ala Leu Val 105 Cys Leu Lys Asp Phe 185 Leu Thr Asp Phe 10 Giu Leu Ile Arg Ala 90 Gly Asp Giu Ile Lys 170 Lys Lys Unk Arg Gly 250 Trp Glu Leu Arg 75 Lys Val Val1 Pro Ala 155 Arg Ser Unk Thr Lys 235 Gin Sen Ile Sen Arg Ile Lys Met Leu Ser Val Tyr Glu Leu Leu Ser Arg Ala Val Cys Gly Ser Leu Val Gly Ser Pro Met Val Ile Lys 110 Leu Val Asp 125 Phe Leu Asp 140 Cys Asp Ile Ala Phe Lys Cys Leu Leu 190 Unk His Leu 205 Phe Leu Leu 220 Lys Arg Ser Ala Lys G lu Leu Gly Arg Cys Ala Cys Phe Pro Unk 175 Ser Unk G lu Gin G ly Asp Gin Asp Phe Gin Trp Val Glu Ser 160 Gly Unk Val Lys Arg 240 INFORMATION FOR SEQ ID NO:834: Wi SEQUENCE CHARACTERISTICS: LENGTH: 252 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) (vi) HYPOTHETICAL: YES ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .252 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:834 Leu Arg Ser Ile Ser Arg Ile Lys Met Leu Ser Val Tyr Giu Lys Gly 1 A.sn Ile Asn Asn Lys Leu Glu Val Ser 145 Gly Lyr Phe Unk 225 Arg Ala Leu Ala G iy Thr Gin Glu Giy 130 Leu Ile Arg Unk Asn 210 Asp Leu Leu Met Ser Giy Leu Lys Lys 115 Ser Ser Asp Leu Lys 195 Gin Leu Arg Asp Glu Leu Asp Val Glu 100 Asn Ala Gin Ser Ser 180 Unk Ile Lys Ala Lys As n Giy Gly Phe Arg G lu Phe Lys Lys 165 Ala Tyr Leu Cys 245 Arg Ala Ala Tyr 70 Glu Ala Asp Lys Ala 150 Giy Trp Ile Glu Pro 230 Ala Val1 Ala Lys S5 Thr Met Lys Leu Gly 135 Arg Arg Ala Unk Ile 215 Leu Cys Leu Met 40 Val Leu Lys Lys G iu 120 G ly Phe Val1 Leu Unk 200 Pro Arg Ala Giu 25 Ala Ile Ala Leu Val 105 Cys Leu Lys Asp Phe 185 Leu Thr Asp Phe Glu Leu Ile Arg Ala 90 Gly Asp Glu Ile Lys 170 Lys Lys Unk Arg G ly 250 Trp Giu Leu Arg 75 Lys Val1 Val1 Pro Ala 155 Arg Ser Unk Thr Lys 235 Gin Leu Arg Cys Leu Ser Val1 Leu Phe 140 Cys Ala Cys Unk Phe 220 Lys Ala Leu Ala Gly Val1 Pro Ile Val 125 Leu Asp Phe Leu His 205 Leu Arg Ser Val Ser G ly Met Lys 110 Asp Asp Ile Lys Leu 190 Leu Leu Ser G iu Leu Gly Arg Cys Ala Cys Phe Pro Unk 175 Ser Unk Giu Gin Asp Gin Asp Phe Gin Trp Val Glu Ser 160 G ly Unk Val Lys Arg 240 INFORMATION FOR SEQ ID NO:835: Ot** *9
C
SEQUENCE CHARACTERISTICS: LENGTH: 597 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: Y-ES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEAUE: NAME/KEY: misc_feature LOCATION .597 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:835 Met Sen Asn Gin Glu Tyr Thr Phe Gin Thr Glu Ile Asn Gin Leu Leu 10 Asp Leu Met Ile His Ser Leu Tyr Sen Asn Lys Glu Ile Phe Leu Arg Glu Met His Gly Ala Lys Ala Ser 145 Ile Leu Val Tyr Lys 225 Met Leu Leu Leu Ile Lys Lys Phe 130 His Ser Lys Val Thr 210 Glu Asn
I
3
T
S
G
S
A
c c c
C
M
G
Ser Phe 9 9 Val Ala Tyr 305 Ser Leu Ile Ser Val 385 Leu Leu Tyr Glu Ile 465 Phe Glu Phe Glu Pro 290 Val Tyr Asn Arg Lys 370 Leu Glu Lys Leu Lys 450 Asp Arg Ile Glu le Ser A 5 hr Asp G er Phe A ly Met A 8 er Gly T 100 sp Ser A et Val A in Ala T lu Cys V 1 lu Glu 1 180 Lys Lys 195 Asp Thr Glu Lys Lys Ser Ala His 260 Gly Ser 275 Phe Asp Lys Arg Leu Arg Val Ser 340 Ser Ala 355 Asp Asn Lys Glu Leu Leu Glu Tyr 420 Leu Gly 435 Tyr Ala Ala Phe Asp Ala His Asp 500 Glu Asn sn lu sp sp 5 hr la la yr al 65 Asp .yr Lys Cys Glu 245 Asp Leu Leu Val Phe 325 Arg Ser Lys Gly Ar Ly Gil G1 Va Se 48 Gl Le Ala S Lys L 5 Ser G 70 Lys S Lys S Leu I Ser L 1 Ala T 150 Lys G Ser H Ser C Phe Asp 230 Leu Asn Glu Phe Phe 310 Val Glu Val Asri Leu 390 g Phe s Glu .i Asn n Lys 1 Met 470 r His 5 u Val u Lys er A 4 eu L 5 in L er A er P le G 1 ys I 35 rp V lu G is P ;lu F lu C 215 ;in Lys Ser Tyr Arg 295 Ile Lys Ile Lys Tyr 375 Tyr Tyr Asn Leu Gly 455 Pro Ser Lys Asp sp 0 ys ys sp he ly 20 le al lu he His 200 Gly Ile Glu G;lu Thr 280 Val Thr G1 Le Ly 36 Hi Gl Se Le As 44 Ty Gl Gl As Ala L Gly L Lys T Leu I 9 Leu S 105 Gin P Val V Ser A Gin G 1 Ala S 185 Ile I Glu C Asn Lys Pro 265 Thr Asp Asp y Val u Gin 345 s Ile 0 s Lys y Asp r Lys u Lys 425 p Leu 0 r Asp y Val u Ser p Gin 505 eu eu hr le 0 er he al sp ly 70 er Pro Gly 31n Asp 250 Leu Leu Tyr Asp Ii 33 G1 Le Ph Ph As 41 Gi Le Va As Le 49 P1 Asp L Asn T 6 Leu T 75 Glu H Ala L Gly V Gin T Gly L 155 Thr C Arg 9 Phe Asp Ala 235 Tyr Ser Phe Lys Asp 315 a Asp 0 n Asn' u Ser e Tyr e Gu 395 p Lys 0 u Asn u Lys 1 Leu n Glu 475 u Lys 0 e Lys ys L 4 hr T 0 hr I is L eu S al G 1 hr L ys G lu I Trp G Pro Asn I 220 Ser Lys Tyr Tyr Ser 300 Lys Ser Lys Glu Glu 380 Asn Gly Gin Ala Leu 460 Tyr Glu Asp eu hr le eu er ly ys ly le lu le 205 Lys Ala Asp Ile Ile 285 Gly Glui G11 Il Il 36 Pr Ly G1 Ly Se 44 Le As Le Le Gl Asn T Pro S Lys A Gly T 9 Gly A 110 Phe T Lys V Lys P Thr L 1 Ile A 190 Phe E Lys C Leu I Phe His 270 Pro Val Leu Asp Leu 350 Glu Phe s Glu u Trp s Ser 430 r Pro u Ser p Lys u Gly u Ile 510 u Leu yr er sp hr sp yr al he eu sp eu lu Trp Tyr 255 Asn Ser Lys Leu Leu 335 Ala Arg Gly Lys Ile 415 Il Le As Th Le 49 Ly Se Leu Ile Asn Ile Lys Ser Thr Glu 160 Phe Ser Thr Val Lys 240 Gin Lys Lys Leu Pro 320 Pro Asn Leu Lys Leu 400 Ser eTyr a Leu p Glu r Pro 480 u Ala s Ala r Gly Glu Ile Lys Gly Val 515 525 Pro Asn Ala Met His Leu 530 Thr Ser Ala Val Ala Leu Ile Gly Asp 535 Met Ala Asn Trp Met Arg Gin Met Gly Gin Ser Val Pro Glu Ser Lys 545 550 555 560 Lys Thr Leu Glu Leu Asn Pro Asn His Ala Ile Leu Gin Lys Leu Leu 565 570 575 Lys Cys Glu Asp Lys Glu Gin Leu Ser Ala Phe Ile Trp Leu Leu Tyr 580 585 590 Asp Gly Arg Ser Phe 595 INFORMATION FOR SEQ ID NO:836: SEQUENCE CHARACTERISTICS: LENGTH: 156 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...156 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:836 Val Asn Leu Gly Ala Tyr Tyr Thr Pro Pro Tyr Leu Val Asp Cys Ala 1 5 10 Tyr Lys Leu Leu Lys Lys His Val Gly Ile Glu Asn Tyr Thr Leu Leu 20 25 Asp Thr Ala Cys Gly Asn Lys Glu Phe Leu Lys Leu His His Pro Lys 35 40 Lys Ile Gly Ala Asp Ile Asp Pro Lys Cys Asp Ala Leu Ile Ile Asn S* 50 55 Ala Leu Ala Asn Pro Lys Arg Glu Asn Tyr Gly. Ile Ser Gin Asp Glu 70 75 Pro Leu Ile Ile Val Gly Asn Pro Pro Tyr Asn Asp Arg Thr Ser Phe 90 Ile Lys Gin Asp Ile Lys Asn Lys Asp Phe Ile Phe Glu Ile Asp Asn 100 105 110 Asp Leu Lys Ser Arg Asp Leu Gly Ile Ser Phe Leu Lys Ser Phe Ala S115 120 125 Ile Leu Lys Pro Ala Phe Ile Cys Val Leu His Pro Leu Ser Tyr Leu 130 135 140 Ile Lys Glu Ala Asn Phe Lys Gin Phe Lys Ala Ile fe 145 150 155 INFORMATION FOR SEQ ID NO:837: a9 SEQUENCE CHARACTERISTICS: LENGTH: 157 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...157 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:837 Met Lys Ser Ile Leu Leu Phe Ile Ile Phe Val Val Cys Gln Leu Glu 1 5 10 is Gly Lys Lys Phe Ser Gin Asp Asn Phe Lys Val Asp Tyr Asn Tyr Tyr 25 Leu Arg Lys Gln Asp Leu His Ile Ile Lys Thr Gln Asn Asp Leu Ser 40 Asn Ala Trp Tyr Leu Pro Pro Gln Lys Ala Pro Lys Glu His Ser Trp 55 Val Asp Phe Ala Lys Lys Tyr Leu Asn Met Met Asp Tyr Leu Gly Thr 70 75 Tyr Phe Leu Pro Phe Tyr His Ser Phe Thr Pro Ile Phe Gln Trp Tyr 90 His Pro Asn Ile Asn Pro Tyr Lys Arg Asn Glu Phe Lys Phe Gln Ile 100 105 110 Ser Phe Arg Val Pro Val Phe Arg His Ile Leu Trp Thr Lys Gly Thr 115 120 125 Leu Tyr Leu Asp Tyr Thr Gln Thr Asn Trp Phe Gin Ile Tyr Asn Asp 130 135 140 Pro Gin Ser Ala Pro Met Arg Met Ile Lys Phe His Ala 145 150 155 INFORMATION FOR SEQ ID NO:838: SEQUENCE CHARACTERISTICS: LENGTH: 191 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori
FEATURE:
NAME/KEY: misc_feature LOCATION 1...191 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:838 Met Gly Leu Met Gly Val Ser Gln Gly Leu Pro Asn Thr Thr Ser Lys 1 5 10 Phe Gly Ile Glu Phe Asp Ser Leu Ala Asp Val Val Ala Phe Gly Val 25 Ala Pro Ser Leu Ile Thr Tyr Phe Tyr Val Gly Tyr Asn Phe Gly Arg 40 Ile Gly Met Ala Val Ser Ala Leu Phe Val Ile Phe Gly Ala Ile Arg 55 Leu Ala Arg Phe Asn Ile Ser Thr Asn Thr Ser Asp Pro Tyr Ser Phe 70 75 Ile Gly Ile Pro Ile Pro Ala Ala Ala Val Leu Val Val Leu Cys Val 90 Leu Leu Asp Asn Lys Tyr His Phe Leu Glu Gly Asn Thr Glu Lys Leu 100 105 110 Phe Leu Gly Phe Ile Val Leu Leu Gly Val Leu Met Val Ser Asn Ile 115 120 125 698 Arg Tyr Pro Asn Phe Lys Lys Val Lys Trp Asn Leu Lys Leu Phe Ile 130 135 140 Leu Val Leu Ile Phe Leu Ser Leu Val Phe Val Arg Pro Leu Glu Ala 145 150 155 160 Leu Ser Val Phe Met Gly Leu Tyr Leu Ile Tyr Gly Ile Ile Arg Trp 165 170 175 Ile Phe Leu Met Val Lys Ile Thr Phe Asn Lys Asn Lys Ser Ala 180 185 190 INFORMATION FOR SEQ ID NO:839: SEQUENCE CHARACTERISTICS: LENGTH: 90 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...90 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:839 Met Ile Gly Val Tyr Pro Asn Tyr Ser Lys Lys Gln Leu Lys Arg Pro 1 5 10 Leu Val Ile Phe Val Ser Arg Glu Leu Ala Leu Ala Asn Gly Ile Leu 20 25 Thr Asp Ala Tyr Asp Ile Glu Ala Asn Leu Tyr Met Asn Ala Arg Ile 40 Val Met Unk Asn Asn Lys Arg Lys His Tyr Glu Gln Arg Val Asn Leu 50 55 His Phe Unk Arg Ser Leu Gly Unk Val Phe Asp His Arg Ser Asn His 70 75 Val Leu Cys Asp Glu Lys Asp Leu Leu Arg INFORMATION FOR SEQ ID NO:840: SEQUENCE CHARACTERISTICS: LENGTH: 277 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...277 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:840 Val Lys Ile Thr Ile Met Ile Lys Asp Phe Asn His Tyr Cys Arg Lys 1 Ile Lys Val1 Phe Cys Asn Ile Leu Ile 145 Ser Arg Pro Thr Giu 225 Val1 Pro Cys Thr Met Val1 Giu Ile Gly Giu Ser 130 Pro Gin Lys Leu Giu 210 Vali Gin Leu Ala Arg Lys Ser Lys Giu Pro As n 115 Trp Asp As n Gin Ser 195 Ser Pro Gin Thr Ile 275 G1y Lys Leu Cys Val1 Leu 100 Pro Gin Tyr His Leu 180 Gly Giu As n Ser Leu 260 Leu Phe Vai Lys Ile Ala Asn Leu Lys Gin Leu Aia Ala Phe 165 Asp G ly Leu Ala Asp 245 Asn Arg Gly Ala Pro 70 Pro Leu Ar; Ile 150 His As n Leu Ala His 230 Asn Ar; Phe Lys 55 Asn Asp Leu Leu Asp 135 Ser Ile Asn Asn Gin 215 Lys Ser Ala Leu 40 Asp Tyr Ala Leu Asp 120 Phe Leu His Leu Giy 200 Lys Ar; Phe Ser 10 Pro Thr 25 Phe Leu Pro Asn Giu Lys Gly Tyr 90 Met Pro 105 Pro Ser Met Ser Thr Ile Ile Ser 170 Lys Asn 185 His Lys Ser Pro Met Gly Val Leu 250 kia Val1 Asn 75 Val1 Thr Thr Unk Asn 155 Cys Ile Phe AsF Let.
Lys Lys Gin Ala Leu Gin Val1 Thr Pro Lys 140 Ser Ile Asn Leu Vai 220 Tyr 1Ala Met Ar; Asn Leu His Asn 125 Tyr Lys Ser Ser Ala 205 Met Gly Thr Gl Ala Lys Pro Lys Ile 110 Phe Giy Lys Leu Ar; 190 Ar; Leu Leu Gin Ala Ile Ile Ser Asp Ser Phe Lys Gly Asp 175 Trp Ar; Ala Ala Phe Lys Ile Val1 Pro Ile G ly Tyr Pro Arg 160 Val1 Ser Val1 Lys Val1 240 Asn .0.
0 *00 Glu Giu Ile Gin Asp His Giu 270 INFORMATION FOR SEQ ID NO:841: SEQUENCE CHARACTERISTICS: LENGTH: 58 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .58 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:841 Val Leu Thr Ser Gly Asp Met Ile Thr Cys Pro Tyr Cys Gly Arg Ile 1 5 10 Leu Tyr Aia Giu Ser Thr His Giu Ser Asn Ala Gin Pro Pro Lys Giu 25 Ser Gin Pro Lys Giu Ser Gin Glu Giu Ser Gin Giu Giu Ser Gin Glu 40 Glu Ser Gin Giu Ala Val Arg Leu Ile Val INFORMATION FOR SEQ ID NO:842: SEQUENCE CHARACTERISTICS: LENGTH: 138 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...138 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:842 Met Ala Leu Asp Lys Arg Ile Trp Met His Phe Asp Leu Leu Pro Phe 1 5 10 Val Phe Ile Ile Pro Leu Leu Val Val Ser Phe Leu Leu Ile Phe Glu 25 Ser Ser Ala Val Leu Ser Leu Lys Gin Gly Val Tyr Tyr Ala Ile Gly 35 40 Phe Leu Leu Phe Trp Val Val Phe Phe Ile Pro Phe Arg Lys Leu Asp 50 55 Arg Trp Leu Phe Ala Leu Tyr Trp Ala Cys Val Ile Leu Leu Ala Leu 65 70 75 Val Asp Phe Met Gly Ser Ser Lys Leu Gly Ala Gin Arg Trp Leu Val 90 Ile Pro Phe Thr Ser Ile Thr Leu Gin Pro Ser Glu Pro Val Lys Asn 100 105 110 Arg Unk Ser Phe Ile Val Gly Ala Phe Unk Unk Asn Unk Pro Asp Unk 115 120 125 Leu Leu Arg Ala Met Ile Gly Ala Cys Phe 130 135 INFORMATION FOR SEQ ID NO:842: SEQUENCE CHARACTERISTICS: LENGTH: 138 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...138 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:842 Met Ala Leu Asp Lys Arg Ile Trp Met His Phe Asp Leu Leu Pro Phe 1 5 10 Val Phe Ile Ile Pro Leu Leu Val Val Ser Phe Leu Leu Ile Phe Glu Ser Phe Arg Val Ile Arg Leu Val1 Phe Phe Met Thr 100 Phe Ala Ser Val1 Leu 70 Ser Ile Val Ile Leu Lys Vai Phe Tyr Trp Ser Lys Thr Leu Gly Ala 120 Gly Ala 135 Gin Phe Ala Leu Gin Phe Cys Gly Val Ile Pro Cys Val Gly Ala 90 Pro Ser Unk Unk Phe T'yr Aia Arg Lys Leu Leu Arg Trp Pro Val 110 Unk Pro 125 Ile Leu Ala Leu Lys Asp INFORMATION FOR SEQ ID NO:843: SEQUENCE CHARACTERISTICS: LENGTH: 279 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc_feature LOCATION .279 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:843 S S S.
S.
Met Lys Leu Asn Asp Pro Phe Thr Ser Pro Asn, Lys Ala Lys Lys Glu 1 Leu Sen Pro Gly Leu Lys Phe Pro Tyr Sen Asp 145 Phe His Phe Giu 50 Arg Glu His Val 130 Ile Cys Met Val1 Leu Leu Gly Thr Leu 115 Sen Ser Leu Pro Lys Gly Phe 20 Leu Gin Lys Sen His Glu Asn Asp Cys 70 Arg Sen Phe 85 Giu Ile Leu 100 Lys Giu Ile Leu Ala Leu Pro Lys Ala 150 Lys Glu Arg 165 Thr Ie Giu 180 Pro Leu Glu Arg Glu 55 Pro Phe Val Gly Glu 135 Leu Val Gly Arg 40 Glu Ile Val Gin G lu 120 Asn Glu Phe Gly 25 Val Thr Glu Asn Lys 105 Ile Pro Val Leu Phe Arg Tyr Glu 90 Ala Gly Asn Ala Lys 170 Leu His Phe Phe Leu Leu 75 His Val Leu Asn Ile Gly Leu Sen 140 Leu Lys 155 Gin Thn Asn Pro Thn Giu Gly Leu Ile Sen 125 Ile Asn Arg Pro His Leu Ser Ile Ile 110 Gly Tyr I le Leu Tyr 190 Leu Glu'Sen Glu Ile Leu Leu Giu Val Cys Pro Sen Cys Ala G lu Trp 175 Ile His Gly Asp Arg Gin Val Sen Ang 160 Asp Ala Met Leu Val Ser 185 Ang Asn Tyr 195 Lys Ser Val Leu Lys Giu Pro His Giu Ala 205 Glu Ile Val Phe Leu Phe 210 Gly Gly Vai Lys Gly Asp Giu Ile Leu 215 Lys 220 702 Leu Ala Ala Lys Leu Lys Ile Pro Phe Leu Val Cys Glu Met Gly Tyr 225 230 235 240 Asp Gln Leu Lys Ser Leu Lys Glu Cys Leu Glu Phe Cys Gly Tyr Asp 245 250 255 Ala Glu Phe Tyr Lys Asp Leu Ser Gly Phe Asp Arg Gly Phe Val Gly 260 265 270 Val Leu Lys Ser Phe Leu Arg 275 INFORMATION FOR SEQ ID NO:844: SEQUENCE CHARACTERISTICS: LENGTH: 36 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...36 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:844 Met Ile Ser Phe Ile Gly Phe Glu Cys Ser Ala Leu Lys Val Phe Leu 1 5 10 Thr Phe Gly Tyr Ile Val Phe Lys Unk Trp His Tyr Ser Ala Ile Arg 20 25 Leu Ile Val Ile INFORMATION FOR SEQ ID NO:845: SEQUENCE CHARACTERISTICS: LENGTH: 129 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...129 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:845 Val Ile Gln Ser His Pro Lys Gln Thr Leu Ile Glu Asp Glu Asn Tyr 1 5 10 Phe Tyr Ala Asn Lys Gly Leu Tyr Lys Thr Asn Lys Glu Ala Phe Leu 25 Arg Val Tyr Lys Ile Pro Glu Ser Met Pro Ile Glu Lys Arg Glu Ser 40 Leu Ser Lys Val Ser Lys Ile Phe Leu Ala Leu Leu Phe Phe Ile Ser 703 55 Ser Met Leu Phe Gly Ile Phe Trp Arg Leu Pro Lys Arg Leu Asp Thr 70 75 Lys Met Ser Leu Glu Ser Ala His Lys Asn Glu Leu Glu Asn Ala Phe 90 Gln Arg Tyr Asp Ala Leu Gly Val Arg Phe Glu Asp Ile Ala Gly Val 100 105 110 Asn Glu Val Lys Glu Glu Leu Leu Glu Val Ile Asp Tyr Leu Lys Lys 115 120 125 Pro INFORMATION FOR SEQ ID NO:846: SEQUENCE CHARACTERISTICS: LENGTH: 127 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...127 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:846 Met Phe Val Val Lys Met Val Leu Gly Phe Leu Ile Leu Leu Ser Pro 1 5 10 Leu Cys Ala Thr Gly Leu Asp Ile Ser Gln Thr Asp Ile Ile Glu Arg 25 Ser Leu Asn Phe Leu Leu Phe Val Gly Ile Leu Trp Tyr Phe Leu Ala 35 40 Lys Arg Leu Arg Ser Phe Leu His Ser Lys Ser.Leu Glu Ile Ser Lys 50 55 Arg Leu Glu Glu Ile Gln Ala Gln Leu Lys Val Ser Lys Glu His Lys 70 75 Lys Lys Leu Leu Lys Glu Leu Glu Gln Ala Lys Glu Lys Ala Glu Leu 85 90 Il e Il e S er Asp Ala Asn Lys Glu Ala Leu His Asp His Ala Lys Ile 100 105 110 Arg Ile Thr Asn Gln Asn Gly Cys Gly Lys Phe Asp Gln Lys Phe 115 120 125 INFORMATION FOR SEQ ID NO:847: SEQUENCE CHARACTERISTICS: LENGTH: 276 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori 704 (ix) FEATURE: NAME/KEY: misc_feature LOCATION .276 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:847 Met Arg Vai Leu Giu Trp Lys Tyr Trp Leu Asn 1 Thr Ile Ser Ser Leu Pro Ala Ile Glu 145 Lys Ala Val Tyr Ala 225 Asn Gin Val Pro Thr Gin Ile Met Lys Asn Ala Thr Arg Lys Asp Gin Ile 115 Ala Arg 130 Giu Val Met Asp Met Ala Leu Asp) 195 Gly Ala 210 Gin Ile Leu Ser Ala Leu Phe Lys 275 Asn Gly Asn Leu Ala Ala 100 Ala Pro Ser Asn 180 Arg Ser Gly Tyr Ile 260 Asp 5 Lys Ile Ala Leu Leu Ile Gin Lys Ala Leu 165 Pro Leu Ile Phe Phe 245 Ile Pro Ile Phe Ala 70 Lys Asn Asn Lys Lys 150 Glu Lys Lys Ser dly 230 Ile Thr Pro Asn Lys 55 Gin Ala Ile Ala Leu 135 G ly Ile Leu Leu Gin 215 Ala Ile Lys Gin Asn 40 Ala Asp Leu Ser Pro 120 Tyr Val1 Leu Ala Thr 200 Ala Leu Asp As n Thr 25 Phe Phe Leu Val1 Phe 105 Phe Asp Leu Lys Pro 185 Pro His Ser Lys Gly 265 10 Phe As n Ala Lys Lys 90 As n Asp Giu Val1 Asp 170 Tyr Ser Gin Leu Thr 250 Ala Lys His Leu Ile 75 Glu Ser Leu Lys Leu 155 Pro G ly Leu Phe I le 235 Leu Asn Thr Ile Leu Leu Ala Phe Ser Phe Ile 140 Trp Lys Lys Lys Ile 220 Asp Asn Asp Gin Ile Ile Ala Gin Gly Ile 125 Thr Ser Ile Ala Ser 205 Ala Lys Asn Pro Lys Ile Lys Val Al a Lys Lys 110 Ser Pro G lu Lys Ser 190 Lys Thr Lys Pro Leu 270 Trp Phe Gly Phe Ala Giu Leu Ala Phe Asn Arg 175 Met Ile Lys Asp Ile 255 Ala Asp Lys Ser Phe Asn His Tyr Asp Lys Leu 160 Ile Glu Ile Asn Lys 240 Giu Lys 0 0@9* *0 0 000* 0* *0 0* 0* 00 0 0 *0 flu.
0* 4 0*0 0 INFORMATION FOR SEQ ID NO:848: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 126 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE:_protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .126 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:848 Val Ala Leu Leu Giu Pro Sen Val Met Tyr Leu Thr Glu Lys Tyr Gin 1 Tyr Val Leu Ser Gly Leu Thr Ser Gly Thr Thr Trp Gly Pro Arg Val Phe Ile Val Pro Leu 115 Phe Val Phe Ile Leu Lys 100 Ile 5 Lys Leu Glu Unk Lys Leu Val Val Ile Lys Pro 70 Lys Phe Phe Thr Phe Ser 55 Leu Glu Ala Ser Trp Ser 40 Leu Gly Lys Thr Ile 120 Gly 25 Leu Phe Gly Leu Trp 105 Trp 10 Leu His Asp Met Arg 90 Tyr Leu Val Lys Trp Unk 75 Leu Phe Ser Ala Asp Leu Thr Leu Leu Lys Leu Tyr Asp Phe Ser Leu Ile 125 Ile Lys Phe Ile Ala Lys 110 Tyr Phe Asp Ala Phe His Tyr Val Tyr Ser Met Phe Ile INFORMATION FOR SEQ ID NO:849: SEQUENCE CHARACTERISTICS: LENGTH: 242 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...242 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:849 t S Sn.
St
S
ten U U *5 S C S
S
S. C S t~
U
65 C
*S
p.
C S
S
Val Gly Leu Met Lys Ile Arg Phe Met Gly Arg Ser Val Phe Val Gly 1 Asp Leu Ile His 65 Lys Val Ser Phe Tyr 145 Ala Ala Asn Arg Leu Gly Ala 50 Phe Ile Ala Gly Tyr 130 Gin Lys Pro Gin Glu 210 Glu Gly Leu Lys Gin Phe Gin 115 Pro Ala Lys Phe Leu 195 Tyr Arg 20 Gin Lys Glu Ser Ser 100 Val Phe Phe Phe Lys 180 Leu Phe 5 Ile Lys His Asp Val 85 Leu Leu Glu Glu Phe 165 Gly Cys Phe Glu Ala Gin Glu 70 Ala Gly Glu Ile Lys 150 Asn His Glu His Glu Val Ile Leu 55 Leu Thr Val Asn Lys 135 Asp Ser Val Gin Lys 215 Lys 40 Asn Gly Asn Val Leu 120 Asn Leu Leu Val Leu 200 His 10 Ala Arg Phe 25 Glu Pro Arg Lys Leu Leu Ile Phe Lys 75 Ser Ile Gly 90 Gly Thr Ile 105 Ala Leu Gin Ser Val Val Gly Val Leu 155 Val Glu Ile 170 Val Cys Ser 185 Ala Lys Arg Phe Pro Pro Glu Arg Lys Gin Arg Ser Ser Arg 140 Glu Ile Gly Leu Asn 220 Glu Leu Arg Met Leu Phe Asp 125 Leu Pro Thr Gly Lys 205 Asp Phe Val Val His Phe Glu 110 Glu Lys Lys Ala Val 190 Lys Arg Trp Leu Gin Asp Asp Ala Ile Glu Arg Leu 175 Phe Leu Ser Leu Glu Lys Lys Ile Glu Ala Phe Ile 160 Ile Cys Gin Ile 706 Pro Val Gly Gin Ala Leu Met Ala Tyr Phe Asn Pro Thr Ile Ile Lys 225 230 235 240 Lys Gly INFORMATION FOR SEQ ID NO:850: SEQUENCE CHARACTERISTICS: LENGTH: 151 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...151 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:850 Val Ser Asp Ser Asn Ala Leu Lys Glu Val Phe Leu Asn Ile Ser Ala 1 5 10 Lys Glu Asp His Cys Asp Val Leu Ile Asn Ser Ala Gly Tyr Gly Val 25 Phe Gly Ser*Val Glu Asp Thr Pro Ile Glu Glu Val Lys Lys Gin Phe 40 Ser Val Asn Phe Phe Ala Leu Cys Glu Val Val Gin Leu Cys Leu Pro 55 Leu Leu Lys Asn Lys Pro Tyr Ser Lys Ile Phe Asn Leu Ser Ser Ile 65 70 75 Ala Gly Arg Val Ser Met Leu Phe Leu Gly His Tyr Ser Ala Ser Lys 85 90 His Ala Leu Glu Ala Tyr Ser Asp Ala Leu Arg Leu Glu Leu Lys Pro 100 105 110 Phe Asn Val Gin Val Cys Leu Ile Glu Pro Gly Pro Val Lys Ser Asn 115 120 125 Trp Glu Lys Thr Ala Phe Glu Asn Asp Glu Arg Lys Asp Ser Val Tyr 130 135 140 Ala Leu Glu Val Asn Ala Ala S 145 150 INFORMATION FOR SEQ ID NO:851: SEQUENCE CHARACTERISTICS: LENGTH: 154 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...154 (xi) SEQUENCE DESCRIPTION: SEQ ID 1Val Ile Val Ala Trp Leu Phe Arg Phe Leu Val Ile Cys Gin Asn Gin Asp Glu 145 Ile Axrg Ala TIyr Ile Phe Giu Lys 130 Leu Thr Gin Leu Gin Arg Giu Giu 115 Leu Lys Leu Phe Leu Phe Giu Lys 100 Ser Ser Ala Leu Leu Ile Ser Asn Leu His Asn Arg Ser Ile Ala Phe Ser Ile Ile Trp Val Tyr Ser Asp Ser Phe Ile Trp Leu Leu Val Ile Ser Ala Arg Lys Leu Ile Gin Arg Lys Arg 75 Asn Arg Lys Asp Ala Lys Glu Ile Ile Ser Lys Lys 110 Asn Asp Giu Asn His Lys 125 Ile Leu Lys Lys Gin Glu
S
S
*5 *5*S 59 4 .5*0
S
S.
INFORMATION FOR SEQ ID NO:852: SEQUENCE CHARACTERISTICS: LENGTH: 326 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/XEY: misc-feature LOCATION l...326 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:852 Val Lys Ala Thr Met 65 Val Val Val Val Asn 145 Leu Met Ala Leu Unk Asp Lys Arg Tyr Gly Leu Ty~r Met Leu Gly Pro Phe Ala Giu 130 Phe Gly Leu Thr Leu Trp Ile Phe Trp 150 Ala Leu Glu Ile Met Sen Gly Val1 135 Gin Giu Phe Leu Met Lys Gly Ala His 125 Ile Met Ser Thr Phe Giu dly 225 Val Phe Val Trp Ala 305 Ser Ser Ser 180 Ile Trp
LYS
Leu Val 260 Leu Ala Ile Pro His 165 Gin Gly Asp Thr Ala 245 Glu Vai Met Phe Trp 325 Ser Gin Ala Giu His 230 Gly Ser Asn Phe Thr 310 Arg Gly Ala Phe Arg 215 Pro Ile Ala Ser Phe 295 Pro Phe Met Gly 200 Tyr Leu Pro Leu.
Ala 280 Asn Lys Ala Phe 185 Leu Asp Val1 Pro Glu 265 Val1 Lys Thr Leu 170 Val1 Leu His Ala Phe 250 Ser Ala Pro Pro Ala Tyr Trp Pro Ile 235 Ser Asn Ala Leu Pro 315 Cys Trp Leu Tyr 220 Leu Val1 His Phe Gin 300 Cys Val1 Phe Leu 205 Ser Gly Phe Ile Tyr 285 Thr Pro Ile 175 Phe Ser Phe Ile Gly 255 Leu Phe Ser Met INFORMATION FOR SEQ ID NO:852: SEQUENCE CHARACTERISTICS: LENGTH: 326 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .326 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:852 4*b* 9* Val Leu Met Ala Leu Unk Asp Lys Arg 1 Lys Ala Thr Met 65 Val Val Val Val Asn Tyr Met Leu 50 Gay Pro Phe Ala Giu 130 Phe Phe Ala 35 Tyr Phe Ala Thr 115 Asp Ile Thr Phe Leu Ile His Ser 100 Arg Ile Ala 5 Met Tyr His Phe Thr Leu Phe Leu Gly Leu Thr Leu Trp, Ile Phe Tyr Trp Ala Leu Glu 55 -Ile Met Ser Gly Val 135 Gin Met Thr 40 Gly G ly Pro Ile Ala 120 Leu Glu Ala 25 Gly Ile Ala Asp Val 105 Phe Ile Asp Tyr 10 Ser Ser Thr Ile Val 90 Pro Ile Leu Val Phe Asn Pro Phe Glu Ile Thr Thr 140 Arg Phe Leu Met Lys Gly Ala His 125 Ile Met Ala Giu Leu Val Asn Gly 110 Thr Thr Leu Gly Leu Glu Ala Gly is Met Val Phe Ser Asn Phe Ala Ile Ala 145 150 155 160 Ser Ser Ile Ser His Ser Gly Phe Ala Leu Ala Cys Val Phe Ile His 165 170 175 Thr Giu Asp Ser Gin Gin Ala Met Phe Val Tyr Trp Phe Met Phe Ala 180 185 190 Phe Thr Tyr Ile Gly Ala Phe Gly Leu Leu Trp Leu Len Lys Ser Arg 195 200 205 Glu Lys Thr Trp Asp Giu Arg Tyr Asp His Pro Tyr Ser Lys Phe Asn 210 215 220 dly Leu Ile Lys Thr His Pro Len Val Ala Ile Leu Gly Ala Ile Phe 225 230 235 240 Val Phe Gly Leu Ala Gly Ile Pro Pro Phe Ser Val Phe Trp Gly Lys 245 250 255 Phe Len Ala Val Giu Ser Ala Leu Gin Ser Asn His Ile Leu Leu Ala 260 265 270 Val Val Met Len Val Asn Ser Ala Val Ala Ala Phe Tyr Tyr Phe Arg 275 280 285 Trp Len Val Ala Met Phe Phe Asn Lys Pro Leu Gin Thr Gin Ser Tyr 290 295 300 Ala Lys Thr Ile The Thr Pro Lys Thr Pro Pro Cys Pro Phe Met Arg 305 310 315 320 Ser Len Leu Pro Trp Arg 325 INFORMATION FOR SEQ ID NO:853: SEQUENCE CHARACTERISTICS: LENGTH: 179 amino acids TYPE: amino acid TOPOLOGY: iinear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylorn (ix) FEATURE: NAME/KEY: misc-feature LOCATION .179 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:8S3 Met A-sn Tyr Pro Asn Leu Pro Asn Ser Ala Len Unk Ile Ser Gin Gin 1 5 10 Pro Glu Val Lys Gin Ile Thr Asn Gin Leu Len Lys Gin Leu Gin Asn 25 Ala Leu Arg Ser Asn Ala His Phe Sen Glu Gin Val Gin Len Sen Leu 40 Lys Cys Ile Val Ang Ile Leu Giu Val Leu Len Ser Leu Asp Phe Phe 55 LYS Asn Ala Asn Giu Ile Asp Ser Sen Leu Arg Asn Sen Ile Giu Trp 70 75 Len Thn Asn Ala Gly Giu Ser Len Lys Len Lys Met Lys Gin Tyr Giu Pe85 90 Arg PePhe Sen Giu Phe Asn Thr Sen Met His Ala Asn Gin Gin Giu 100 105 110 Val Thr Asn Thr Leu Asn Ala Asn Ala Gin Asn Ile Lys Sen Unk Ile 115 120 125 Lys Unk Leu Gin Asn Gin Leu Ile Gin Thr Thn Thr Arg Leu Len Thn 130 135 140 Ser Tyn Gin Ile Phe Leu Asn Gin Ala Arg Asp Asn Ala Asn Asn Gin 145 150 155 160 Ile Thr Lys Asn Lys Thn Unk Ser Leu Gin Ala Ile Thr Gin Ala Lys 165 170 175 Asn Asn Ser INFORMATION FOR SEQ ID NO:854: SEQUENCE CHARACTERISTICS: LENGTH: 240 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 240 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:854
S.
S S .5S*
S
SS**
*SS*
S
*5*e *5
S
Met Lys Ser Val Leu 65 Lys Ang
LYS
Asn Ile 145 Thr Val Thr Sen Glu 225 Ile Gly Val Ala Pro Ile Ala Ile 130 Giu Tyr Lys Arg Ang 210 Lys Leu Phe Phe Glu Asp 115 Lys His Ala Gin Gly 195 Val His Lys Gly Gly Pro Thr Ala 100 Glu Gly Asp Tyr Unk 180 Arg Arg Pro Asp Leu Thr Lys Lys 85 Leu Cys Leu Gin Pro 165 Ser Arg Gly Leu Arg Giu Gly Ang 70 Arg Ile Glu Leu Gly 150 Gly Unk Trp Lys Pro 230 Asn Ile Arg 55 Phe Ala Asn Leu His 135 Thr Gly Asri Asn Gly 215 din Ala 25 Lys Gin Pro Glu Ala 105 Asp Thr Ile Val Arg 185 Gly Lys Phe Phe Asn Cys 75 Ile Leu Glu Leu Leu 155 Gly Asp Val Lys Ser Leu Leu Phe Phe Ala Val1 Ile 140 Gly Ala Val Ala Pro 220 Cys Gin Gin Asp Ser Leu Met 125 Leu Sen Ser Ala Lys 205 Lys Ile Asn Ser Lys Lys Ser Leu Lys Lys Gly Leu Arg Gly Gly Lys Lys Leu Met Gly 110 Ile Pro Ile Lys Gly 190 Pro Sen Phe Ala Asn Leu Gin Thr Leu Asp Ser Ala Ala 175 Thr Lys Gly Phe Thr His Gin Asn Asp Asn Thr Met Giy 160 Unk Asn Val1 Tyr Gly 240 Thr Arg Gin Gly Leu Thr Ser 235 INFORMATION FOR SEQ ID NO:854: SEQUENCE CHARACTERISTICS: LENGTH: 240 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION I1.. .240 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:854 Met Ile Asn Ser Lys Lys Ser Leu Lys 1 Lys Ser Val1 Leu Lys Arg Lys Asn Ile 145 Thr Val Thr Ser Giu 225S Ile Gly Val Ala Pro Ile Ala Ile 130 Giu Lys Arg Arg 210 Lys Leu Phe Phe Tyr Giu Asp Tyr 115 Lys His Ala Gin G ly 195 Val1 His Lys Gly Gly Pro Thr Ala 100 Giu Gly Asp Unk 180 Arg Arg Pro 5 Asp Leu Thr Lys Lys Leu Cys Leu Gin Pro 165 Ser Arg Gly Leu Arg Giu Gly Arg 70 Arg Ile Giu Leu Gly 150 Gly Unk Trp Lys Pro 230 Asn Ile Arg 55 Phe Ala Asn Leu His 135 Thr G ly Asn Asn Gly 215 Gin G ly Ala 40 Arg Ile Ile Asn Asp 120 Leu Ile Unk Leu Pro 200 Asp Thr Ala 25 Lys Gin Pro Giu Ala 105 Asp Thr Ile Val1 Arg 185 Gly Lys Thr Lys 10 His Ala Giu Leu Thr 90 G ly Trp Arg Asn Tyr 170 Ala Cys Pro Gly Leu Arg Phe Sen Cys Phe Leu Gin Asn Leu Gin Cys Phe Asp 75 Ile Phe Ser Leu Ala Leu Giu Val Met 125 Leu Ile Leu 140 Leu Gly Sen 155 Gly Ala Ser Asp Vai Ala Val Ala Lys 205 Lys Pro Lys 220 Gly Gly Lys Lys Leu Met Gly 110 Ile Pro Ile Lys Gly 190 Pro Ser Phe Ala Asn Leu Gin Thr Leu Asp Ser Ala Ala 175 Thr Lys C ly Phe Thr His Gin As n Asp Asn Thr Met Gly 160 Unk Asn Val Tyr Gly 240
S*
a.
a.
a. a Arg Gin Gly Leu Thr Ser 235 9 a.
a a INFORMATION FOR SEQ ID NO:855: Wi SEQUENCE CHARACTERISTICS: LENGTH: 160 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1. .160 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:855 Val Phe Ala Thr Asp Ser Ser Ser Phe Sen Met Gly Leu Thr Met Ala 1 5 10 is 712 Ser Ala Tyr Glu Pro Ile Ser Gly Ser Gin Lys Pro Ile Val Gly Gin 25 Ala Leu Leu Leu Leu Ala Ile Leu Ile Leu Leu Asp Leu Ser Phe His 40 His Gin Ile Ile Leu Phe Val Asp His Ser Leu Lys Ala Val Pro Leu 55 Gly Arg Phe Val Phe Glu Pro Glu Leu Ala Lys Asn Ile Val Lys Ala 70 75 Phe Ser His Leu Phe Val Ile Gly Phe Ser Met Ala Phe Pro Ile Leu 90 Cys Leu Val Leu Leu Ser Asp Ile Ile Phe Gly Met Ile Met Lys Thr 100 105 110 His Pro Gin Phe Asn Leu Leu Ala Ile Gly Phe Pro Val Lys Ile Ala 115 120 125 Ile Gly Phe Val Gly Ile Ile Leu Ile Ala Ser Ala Ile Met Gly Arg 130 135 140 Phe Lys Glu Glu Ile Ser Leu Ala Phe Ser Val Ile Ser Lys Ile Phe 145 150 155 160 INFORMATION FOR SEQ ID NO:856: SEQUENCE CHARACTERISTICS: LENGTH: 94 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...94 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:856 Met Tyr Gly Val Lys Glu Ile Lys Asp Lys Ile Asp Lys Gin Leu His 1 5 10 Asn Asn Asp His Leu Phe Glu Gly Leu Phe Gly Glu Lys Glu Asp Leu 25 Lys Lys Leu Val Ser Met Phe Gly Gin Leu Arg Phe Gin Lys Arg Trp 35 40 Ser Gin Thr Pro Arg Val Pro Gin Thr Ser Val Leu Gly His Thr Leu 55 Cys Val Ala Ile Met Gly Tyr Leu Leu Ser Phe Asp Leu Lys Ala Cys 65 70 75 Lys Ser Met Arg Ile Asn His Phe Leu Gly Gly Leu Phe Pro 85 INFORMATION FOR SEQ ID NO:857: SEQUENCE CHARACTERISTICS: LENGTH: 146 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...146 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:857 Met Thr Leu Asp Asp Leu Leu Gly Gly Ser Leu Asp Pro His Cys Phe 1 5 10 Cys Lys Pro Leu Ile Lys Thr Lys Lys Asp Gin Glu Arg Leu Leu Ser 25 Leu Ala Leu Lys Ala His Pro Lys Ile Ser Phe Gly Lys Asp Ser Ala 40 Pro His Phe Ile Ser Lys Lys His Ser Ala Asn Ile Pro Ala Gly Ile 55 Phe Ser Ala Pro Ile Leu Leu Pro Ala Leu Cys Glu Leu Phe Glu Lys 70 75 His Asn Ala Leu Glu Asn Leu Gin Ala Phe Ile Ser Asp Asn Ala Lys 90 Lys Ile Tyr Ala Leu Asp Asn Leu Pro Ser Lys Lys Ala His Leu Ser 100 105 110 Lys Lys Pro Phe Ile Val Pro Thr His Thr Leu Cys Leu Asn Glu Lys 115 120 125 Ile Ala Ile Leu Arg Gly Gly Glu Thr Leu Ser Trp Asn Leu Gin Glu 130 135 140 Ile Ala 145 INFORMATION FOR SEQ ID NO:858: SEQUENCE CHARACTERISTICS: LENGTH: 204 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES 9 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori S(ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...204 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:858 S Val Ser Gly Val Val Leu Ser Lys Phe Asp Ser Asp Ser Lys Gly Gly 1 5 10 Ile Ala Leu Gly Ile Thr Tyr Gin Leu Gly Leu Pro Leu Arg Phe lle 20 25 Gly Ser Gly Glu Lys Ile Pro Asp Leu Asp Val Phe Met Pro Glu Arg 40 Ile Val Gly Arg Leu Met Gly Ala Gly Asp Ile Ile Ser Leu Ala Glu 55 Lys Thr Ala Ser Val Leu Asn Pro Asn Glu Ala Lys Asp Leu Ser Lys 70 75 Lys Leu Lys Lys Gly Gin Phe Thr Phe Asn Asp Phe Leu Asn Gin Ile 90 Glu Lys Val Lys Lys Leu Gly Ser Met Ser Ser Leu Ile Ser Met Ile 100 105 110 714 Pro Gly Leu Gly Asn Met Ala Ser Ala Leu Lys Asp Thr Asp Leu Glu 115 120 125 Ser Ser Leu Giu Val Lys Lys Ile Lys Ala Met Val Asn Ser Met Thr 130 135 140 Lys Lys Giu Arg Giu Asn Pro Glu Ile Leu Asn Gly Ser Arg Arg Lys 145 150 155 160 Arg Ile Ala Leu Gly Unk Gly Leu Giu Unk Unk Glu Ile Asn Arg Ile 165 170 175 Ilie Lys Arg Phe Asp Gin Ala Ser Lys Met Ala Lys Arg Leu Thr Asn 180 185 190 Lys Lys Gly Ilie Ser Asp Leu Met Asn Leu Unk Unk 195 200 INFORMATION FOR SEQ ID NO:858: SEQUENCE CHARACTERISTICS: LENGTH: 204 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 204 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:858 Val Ser Gly Val Val Leu Ser Lys Phe Asp Ser Asp Ser Lys Giy Giy 1 5 10 Ile Ala Leu Gly Ile Thr Tyr Gin Leu Gly Leu Pro Leu Arg Phe Ile 25 Gly Sen Gly Glu Lys Ile Pro Asp Leu Asp Val Phe Met Pro Glu Arg 35 40 Sle Vai Gly Arg Leu Met Gly Ala Gly Asp Ile Ile Ser Leu Ala Glu 55 Lys Thr Ala Ser Val Leu Asn Pro Asn Giu Ala Lys Asp Leu Ser Lys 70 75 Lys Leu Lys Lys Gly Gin Phe Thr Phe Asn Asp Phe Leu Asn Gin Ile :85 90 Glu Lys Val Lys Lys Leu Gly Ser Met Ser Sen Leu Ile Sen Met Ile 100 105 110 Pro Gly Leu Gly Asn Met Ala Sen Ala Leu Lys Asp Thr Asp Leu Glu *115 120 125 *Sen Ser Leu Glu Val Lys Lys Ile Lys Ala Met Val Asn Ser Met Thr 130 135 140 Lys Lys Giu Ang Glu Asn Pro Glu Ile Leu Asn Gly Ser Arg Arg Lys 145 150 155 160 Arg Ile Ala Leu Gly Unk Gly Leu Giu Unk Unk Glu Ile Asn Arg Ile 165 170 175 Ile Lys Arg Phe Asp Gin Ala Sen Lys Met Ala Lys Arg Leu Thr Asn 180 185 190 Lys Lys Gly Ile Ser Asp Leu Met Asn Leu Unk Unk 195 200 INFORMATION FOR SEQ ID NO:859: SEQUENCE CHARACTERISTICS: 715 LENGTH: 173 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...173 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:859 Met Gly Val Leu Gly Met Phe Ala Phe Phe Ser Trp Val Phe Leu Phe 1 5 10 Lys His Asn Leu Ser His Lys Ile Arg Leu Tyr His Glu Lys Lys Asp 25 Phe Asp Lys Leu Leu Lys Gin Ile Leu Ser Gin Asp Thr Gin Lys Thr 40 Phe Leu Lys Thr Lys Phe Lys Ser Asp Leu Ala Lys Asn Leu Ser Gin 55 Ile Leu Ala Arg Tyr Asp Leu Lys Ala Asp Leu Asn Thr Pro Asn Ser 70 75 Gly Cys Glu Lys Val Asp Asn Leu Phe Lys His Tyr His Asn Ile Glu 90 Asn Asn Thr Leu Glu Pro Lys Asp His Ala Lys His Ser Leu Ala Tyr 100 105 110 Glu His Ala Tyr Phe Ser Lys Arg Leu Lys Ala Phe Ile His Asn Asp 115 120 125 Leu Lys Asn Ala Phe Glu Val Leu Thr Asn Ala Gin Ile Pro Leu Glu 130 135 140 Leu Arg Arg Tyr Ala Tyr Arg Asn Arg Pro Lys Arg Gin Gin Lys Arg 145 150 155 160 Gly Phe Lys Gly Cys Glu Cys Asp Ala Arg Gly Phe Gly 165 170 INFORMATION FOR SEQ ID NO:860: SEQUENCE CHARACTERISTICS: LENGTH: 193 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCEt ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...193 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:860 Val Ser Val Pro Ala Thr Ser Ala Asn Leu Gly Pro Gly Phe Asp Cys 1 5 10 Leu Gly Leu Ser Leu Asn Leu Arg Asn Arg Phe Phe Ile Glu Pro Ser 25 716 Asn Ile His Ala Val Lys Leu Val Gly Glu Gly Glu Gly Ile Pro Lys 40 Phe Leu Thr Asn Asn Ile Phe Thr Lys Val Phe Tyr Glu Ile Leu Lys 55 Lys His Gly Asn Asp Gly Ser Phe Lys Phe Leu Leu His Asn Lys Val 70 75 Pro Ile Thr Arg Gly Met Gly Ser Ser Ser Ala Met Ile Val Gly Ala 90 Val Ala Ser Ala Phe Ala Phe Leu Gly Phe Ala Phe Asp Arg Glu Asn 100 105 110 Ile Leu Asn Thr Ala Leu Ile Tyr Glu Asn His Pro Asp Asn Ile Thr 115 120 125 Pro Ala Val Phe Gly Gly Tyr Asn Ala Ala Phe Val Glu Lys Lys Lys 130 135 140 Val Ile Ser Leu Lys Thr Lys Ile Pro Ser Phe Leu Lys Ala Val Met 145 150 155 160 Val Ile Pro Asn Arg Val Ile Ser Thr Lys Gin Ser Arg His Leu Cys 165 170 175 Pro Ser Val Thr Ala Cys Lys Lys Ala Cys Leu Thr Phe Arg Met Arg 180 185 190 Val INFORMATION FOR SEQ ID NO:861: SEQUENCE CHARACTERISTICS: LENGTH: 104 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: S* NAME/KEY: misc_feature LOCATION 1...104 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:861 Val Ala Lys Asn Leu Val Ala Ser Gly Val Cys Asp Lys Ala Thr Val 1 5 10 S Gin Leu Ala Tyr Ala Ile Gly Val Ile Glu Pro Val Ser Ile Tyr Val 25 Asn Thr His Asn Thr Ser Lys His Ser Ser Ala Glu Leu Glu Lys Cys 40 Val Lys Ser Val Phe Lys Leu Thr Pro Lys Gly Ile Ile Glu Ser Leu s. 55 Asp Leu Leu Arg Pro Ile Tyr Ser Leu Thr Ser Ala Tyr Gly His Phe 65 70 75 Gly Arg Glu Leu Glu Glu Phe Thr Trp Glu Lys Thr Asn Lys Val Glu 90 Glu Ile Lys Ala Phe Phe Lys Arg 100 INFORMATION FOR SEQ ID NO:862: SEQUENCE CHARACTERISTICS: LENGTH: 355 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...355 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:862 Val Arg Leu Phe Arg Phe Val Gly Trp Tyr Tyr Phe Lys Tyr Phe Leu 1 5 10 Ile Val Leu Leu Ala Leu Glu Leu Phe Phe Val Gly Ile Asp Ser Leu 25 Lys Tyr Ala Asp Lys Met Pro Asp Ser Ala Asn Met Ile Ile Leu Phe 40 Phe Thr Tyr Asp Ile Leu Phe Ala Leu Asn Tyr Thr Leu Pro Ile Ser 55 Leu Leu Leu Ala Met Val Leu Phe Tyr Ile Thr Phe Ile Lys Ser Asn 70 75 Gin Tyr Thr Ala Leu Leu Ser Ile Gly Phe Ser Lys Cys Gin Ile Leu 90 Ser Pro Ile Phe Leu Ile Ser Leu Phe Phe Thr Ala Val Tyr Val Gly 100 105 110 Leu Asn Ala Thr Pro Phe Val Tyr Met Glu Glu Lys Thr Gin Asn Leu 115 120 125 Ile Tyr Lys Asp Asn Ser Leu Ser Val Ser Glu His Leu Leu Val Lys 130 135 140 Tyr Asn Asp Asp Tyr Val Tyr Phe Asp Lys Ile Asn Pro Leu Leu Gin 145 150 155 160 Lys Ala Gin Asn Ile Lys Val Phe Arg Leu Lys Asp Lys Thr Leu Glu 165 170 175 Ser Tyr Ala Glu Ala Lys Glu Ala Phe Phe Glu Asp Lys Tyr Trp Ile 180 185 190 Leu His Asp Thr Thr Ile Tyr Glu Met Pro Leu. Ser Phe Glu Leu Gly 195 200 205 Ala Asn Ala Leu Asn Thr Thr His Leu Glu Thr Phe Lys Thr Leu Lys 210 215 220 Asn Phe Arg Pro Lys Val Leu Asp Thr Ile Tyr Gin Asn Lys Pro Ala 225 230 235 240 Val Ser Ile Thr Asp Ala Leu Leu Ser Leu His Ala Leu Val Arg Gin 245 250 255 Asn Ala Asp Thr Lys Lys Val Arg Ser Phe Leu Tyr Val Phe Ala Ile 260 265 270 Leu Pro Phe Phe Val Pro Phe Leu Ser Val Leu Ile Ala Tyr Phe Ser 275 280 285 Pro Ser Leu Ala Arg Tyr Glu Asn Leu Ala Leu Leu Gly Leu Lys Phe 290 295 300 Ile Ile Ile Thr Leu Val Val Trp Gly Leu Phe Phe Ala Leu Gly Lys So 305 310 315 320 Phe Ser Ile Ser Gly Ile Leu Ile Pro Glu Ile Gly Val Leu Ser Pro 325 330 335 Phe Phe Val Phe Leu Ala Leu Ser Leu Trp Tyr Phe Lys Lys Leu Asn 340 345 350 Lys Arg Leu 355 INFORMATION FOR SEQ ID NO:863: SEQUENCE CHARACTERISTICS: LENGTH: 92 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...92 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:863 Glu Lys Ala His Pro Asp Val Phe Asn Leu 5 10 Glu Gly His Leu Thr Asp Ser Lys Gly Val 25 Thr Ile Leu Ile Leu Thr Ser Asn Val Ala 40 Glu Asp Leu Ser Glu Ala Asp Lys Gin Lys 55 Arg Gin Phe Phe Lys Pro Glu Phe Leu Asn 70 75 Ser Phe Asn Ala Leu Asp Ser His Ala Ile 85 Val 1 Asp Asn Glu Leu 65 Ile Leu Leu Gin Val Leu Arg Val Asp Phe Lys Ser Gly Ala Leu Leu Ala Ile Lys Glu Ser Arg Leu Asp Glu Ile Ile 0 0 *0 *0 0 f INFORMATION FOR SEQ ID NO:863: SEQUENCE CHARACTERISTICS: LENGTH: 92 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...92 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:863 Val Glu Lys Ala His Pro Asp Val Phe Asn Leu 1 5 10 Asp Glu Gly His Leu Thr Asp Ser Lys Gly Val 25 Asn Thr Ile Leu Ile Leu Thr Ser Asn Val Ala 40 Glu Glu Asp Leu Ser Glu Ala Asp Lys Gin Lys Leu Arg Gin Phe Phe Lys Pro Glu Phe Leu Asn 70 Ile Ser Phe Asn Ala Leu Asp Ser His Ala Ile Leu Gin Val Val Asp Phe Gly Ala Leu Ile Lys Glu Leu Asp Glu INFORMATION FOR SEQ ID NO:864: SEQUENCE CHARACTERISTICS: LENGTH: 82 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 2 .82 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:864 Leu Val Phe Leu Asp Arg Arg Leu Ile Val Met Val Thr Asp Ser Lys 1 5 10 is Gly Sen Arg Tr Ile Asn Val His Ile Leu Phe Arg Gin Ile Ser Leu 25 Tyr Ala Leu Leu Sen Val Val Gly Ser Leu Leu Phe Leu Gly Val Ser 40 Leu Leu Val Leu Asn Lys Glu Ile Lys Asn Ile Glu Lys Gin His Ala 55 *Leu Unk Thn Lys Giu Phe Giu Lys Lys Ang Giu Thr Asn Giu Unk Leu 70 7S Ser Unk INFORMATION FOR SEQ ID NO:864: SEQUENCE CHARACTERISTICS: LENGTH: 82 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .82 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:864 Leu Val Phe Leu Asp Ang Arg Leu Ile Val Met Val Thr Asp Ser Lys 1. 5 2.0 dly Ser Arg Tyr Ile Asn Val His Ile Leu Phe Arg Gln Ile Ser Leu 25 Tyr Ala Leu Leu Ser Val Val Gly Sen Leu Leu Phe Leu Gly Val Sen 40 Leu Leu Val Leu Asn Lys Glu Ile Lys Asn Ile Glu Lys Gin His Ala so 55 Leu Unk Thr Lys Glu Phe Giu Lys Lys Arg Glu Thn Asn Giu Unk Leu 70 75 720 Ser Unk INFORM4ATION FOR SEQ ID NO:86S: SEQUENCE CHARACTERISTICS: LENGTH: 233 amnino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE:.
NAME/KEY: misc-feature LOCATION .233 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:865 a
S
S.
S
r, Leu 1 Thr Gin
LYS
Thr Ile Leu Lys Ala Giu 145 Arg Thr Gin Giu Pro 225 Ser Leu Met Unk Val Leu Asn Ala Lys Giu Cys Vai Unk Pro Ile Ser Gin 35 Val Leu Tyr Leu Val1 115 Thr Sen Leu His Gin 195 Ile
LYS
Val1 20 Ser Lys Asn Thr Ile 100 Lys Leu Vai Val Asp 180 Gin Ile Ala Tyr Lys Lys Phe 70 Glu Gly Phe Thr Leu 150 Lys Asp Lys Pro Gin 230 Ala Leu Asn Leu Asp Giu Asn Cys Gly Sen Asn Sen Asn Lys Val Sen Val Ang 160 Gly Asp 175S Asn Sen Gly Thr Asp Gly 555.
S S 555 5 INFORMATION FOR SEQ ID NO:865: Wi SEQUENCE CHARACTERISTICS: LENGTH: 233 amino acids TYPE: amino acid TOPOLOGY: iinean (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .233 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:865 Leu Ser Leu Met Unk Val Leu Asn Ala 9 .9 9.*a 9 9 9 9. 9 999* *99* 9.
9 9 9*9 9
I
Thr Gin Lys Thr Ile Leu Lys Ala Giu 145 Arg Thr Gin Giu Pro 225 Ser Gin Val Leu Tyr Leu Val1 115 Thr Ser Leu His Gin 195 Ile Lys Val Ser Lys Asn Thr Ile 100 Lys Val Val Asp 180 Gin Ile Ala 5 Lys Tyr Asp Thr Pro Pro Ile Lys Leu Aia 165 Phe Ala Leu Trp, Tyr Lys Lys Phe 70 Giu Gly Phe Thr Leu 150 Lys Asp Lys Pro Gin 230 Lys 10 Ser Met Val1 Gly Lys 90 Phe As n Phe Gly Ile 170 Ala Asn Tyr Giu Cys Val Unk Pro Ile Ala Ala Ile Tyr Phe Leu Arg Lys Lys 155 Val1 Lys Ala G ly Ile Asp Asp Val1 Lys Tyr Gin 125 Pro Lys Gin Aia Lys 205 Trp Arg As n Leu Lys Giu Ala 110 Lys Gin Ala Val1 Lys 190 Phe Glu Ala Asn Asp Asn Gly Asn Asn Val1 Val1 Gly 175 Asn Gly Asp INFORMATION FOR SEQ ID NO:866: SEQUENCE CHARACTERISTICS: LENGTH: 239 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .239 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:866 Met Ile Tyr Gly Val Leu Asp Giy Leu Phe Leu Ala Ile Leu Gin Ala 10 Gin Asn Tyr Arg Phe His Ser Leu Tyr Leu Phe Glu Glu Asn Leu Asp 25 Leu Phe Lys Ile Ser Cys Tyr Phe Ala Arg Tyr Glu Asp Leu Ile Lys 40 Lys Gly Ala Lys Leu Phe Ile Gln Gly Phe Phe Asn Pro Asn Giu Leu 55 Lys Met Asp Phe Leu Lys Arg Pro Ile Thr His Ser Phe Leu Lys Leu 70 75 Glu Ile Met Pro Tyr Lys Ser Ala Phe Asn Leu Arg Met Arg Giu Asn 90 Ile Gin Ser Tyr Tyr Lys Gin Ala Leu Arg Gly Trp Gly Ser Phe Giu 100 105 110 Asp Glu Leu Leu Gly Leu Lys Asn Thr Leu Lys Asn Leu Pro Leu Tyr 115 120 125 Gin Thr Leu Lys Thr Lys Pro Lys Lys Ile Asn Ala Pro Ile Cys Val 130 135 140 Val Gly Asn Gly Pro Ser Leu Asp Leu Leu Leu Asp Phe Leu Lys Glu 145 150 155 160 Asn Glu Giu Lys Phe Ile Ile Phe Ser Cys Gly Thr Ala Leu Lys Pro 165 170 175 Leu Lys Ala His Gly Val Lys Val Asp Phe Gin Ile Glu Val Glu Arg 180 185 190 Ile Asp Tyr Leu Lys Glu Val Leu Glu Arg Ala Pro Leu Glu Asp Thr 195 200 205 Pro Leu Met Gly Ala Asn Met Leu Asn Pro Asn Ala Phe Asp Leu Ala 210 215 220 Lys Glu Ala Leu Met Phe Met Arg Gly Gly Ser Ala Cys Ala Val 225 230 235 INFORMATION FOR SEQ ID NO:867: {i)SEQUENCE CHARACTERISTICS: LENGTH: 85 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION (xi) SEQUENCE DESCRIPTION: SEQ ID NO:867 Met Leu Ala Ala Gly Leu Thr Leu Pro Glu Phe Gly Cys Tyn Leu Sen 1 5 10 His Tyr Leu Leu Trp Lys Giu Cys Val Lys Leu Asp Gin Pro Val Val 25 Ile Leu Glu Asp Asp Val Thr Leu Giu Ser His Phe Met Gin Ala Leu 40 Glu Asp Cys Leu Lys Sen Pro Phe Asp Phe Val Arg Leu Tyr Gly Cys 55 Tyr Trp Tyr Tyr Gin Arg Asp Lys Ile Pro Cys Phe Ala Gin Arg Ile 70 75 Cys Ile Sen Ser Leu INFORMATION FOR SEQ ID NO:867: SEQUENCE CHARACTERISTICS: LENGTH: 85 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KE.Y: misc-feature LOCATION (xi) SEQUENCE DESCRIPTION: SEQ ID NO:867 *Leu Ala Ala Gly Leu Thr Leu Pro Giu Phe 10 Tyr Leu Leu Trp Lys Giu Cys Val Lys Leu 25 *Leu Glu Asp Asp Val Thr Leu Glu Ser His 40 Asp Cys Leu Lys Ser Pro Phe Asp Phe Val s0 55 *Trp, Tyr Tyr Gin Arg Asp Lys Ile Pro Cys 70 75 Sle Ser Ser Leu Met His Ile 65 Cys G1y Cys Tyr Leu Ser Asp Gin Pro Val Val Phe Met Gin Ala Leu 4S Arg Leu Tyr Gly Cys Phe Ala Gin Arg Ile a. a. a.
a. a a a ~ORMATION FOR SEQ ID NO:868: SEQUENCE CHARACTERISTICS: LENGTH: 289 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1. 289 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:868 Met Leu Ala Phe Leu Lys Thr Pro Arg Asn Sen Ala 1 5 10 Ile Phe Val Gly Ala Leu Leu Phe Tyr Trp, Cys Ala 25 His Ser Asp Phe Thr Tyr Leu Leu Pro Leu Ile Ile 40 Leu Val Tyr Gly Val Leu Phe Tyr Leu Leu Leu Tryr 55 Itrr Phe Arg Leu Leu Ser Phe Leu Gly Ser Ser Phe 70 75 Gly Phe Asp Trp, Leu Val Pro Asp Sen Phe Phe Sen 90 Phe Leu Val Phe Ile Tyr Ala Arg Leu G lu His Ser Leu Leu Val1 Asn Pro Val Gly Ser Ala Pro Phe Phe 724 Arg Val. Asp Lys Leu Ser Leu Gly Leu Ile Phe Leu Ala Cys Ile Phe 100 105 110 Leu Ser Ala Gin Asn Leu Lys Lys Tyr Arg Met Ile Gly Val Leu Leu 115 120 125 Leu Leu Gly Ala Leu Asp Phe His Phe Phe Lys Ile Ser Asp Leu Lys 130 135 140 Glu Val Gly Asn Ile Glu Leu Val Ser Thr Arg Thr Pro Gin Asp Leu 145 150 155 160 Lys Phe Asp Ser Asn Tyr Leu Asn Asn Ile Giu Asn Asn Ile Leu Lys 165 170 175 Giu Ile Lys Leu Ala Gin Ser Lys Gin Lys Thr Leu Ile Val Phe Pro 180 185 190 Giu Thr Ala Tyr Pro Ile Ala Leu Giu Asn Ser Pro Phe Lys Thr Gin 195 200 205 Leu Glu Asp Leu Ser Asp Lys Ile Ala Ile Leu Ile Gly Thr Leu Arg 210 215 220 Ala Gin Gly Tyr Ser Leu Tyr Asn Ser Ser Phe Leu Phe Ser Lys Lys 225 230 235 240 Ser Val Gin Ile Ala Asp Lys Val Ile Leu Ala Pro Phe Gly Giu Ile 245 250 255 Met Pro Leu Pro Giu Phe Leu Gin Lys Pro Leu Giu Lys Leu Phe Phe 260 265 270 Ala Arg Ala Leu Ile Tyr Thr Ala Thr Leu Pro Ile Ser Ala Ile Leu 275 280 285 His INFORMATION FOR SEQ ID NO:869: SEQUENCE CHARACTERISTICS: LENGTH: 436 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY misc-feature LOCATION .436 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:869 Met Asn Asp Pro Lys His Val. Val. Tyr Val. Trp Leu Asp Ala Leu Leu 1 5 10 Asn Tyr Ala Sen Ala Leu Gly Tyr Leu Asn Gly Leu Asp Asn Lys Met 25 Ala His Phe Giu Arg Ala Akg His Ile Val. Gly Lys Asp Ile Leu Arg 40 Phe His Ala Ile Tyr Tnp Pro Ala Phe Leu Met Ser Leu Asn Leu Pro 55 Leu Phe Lys Gln Leu Cys Va]. His Gly Trp Trp Thr Ile Glu Gly Val 70 75 Lys Met Ser Lys Ser Leu Gly Asn Val Leu Asp Ala Gin Lys Leu Ala 90 Met Giu Tyr Gly Ile Giu Glu Leu Arg Tyr Phe Leu Leu Arg Glu Va.
100* 105 110 Pro Phe Gly Gin Asp Gly Asp Phe Sen Lys Lys Ala Leu Va]. Giu Ang 115 120 125 Ile Asn Ala Asn Leu Asn Asn Asp Leu Gly Asn Leu Leu Asn Arg Leu 130 135 140 Leu Giy Met Ala Lys Lys Tyr Phe Asn Tyr Ser Leu Lys Ser Thr Lys 145 150 155 160 Ile Thr Ala Ty~r Tyr Pro Lys Giu Leu Giu Lys Ala His Gin Ile Leu 165 170 175 Asp Asn Ala Asn Ser Phe Vai Pro Lys Met Gln Leu His Lys Ala Leu 180 185 190 Glu Giu Leu Phe Asn Ile Tyr Asp Phe Leu Asn Lys Leu Ile Ala Lys 195 200 205 Giu Giu Pro Trp Val Leu His Lys Asn Asn Giu Ser Giu Lys Leu Glu 210 215 220 Ala Leu Leu Ser Leu Ile Ala Asn Thr Leu Leu Gin Ser Ser Phe Leu 225 230 235 240 Leu Tyr Ala Phe Met Pro Lys Ser Ala Met Lys Leu Ala Ser Ala Phe 245 250 255 Arg Val Giu Ile Thr Pro Asn Asn Tyr Giu Arg Phe Phe Lys Ala Lys 260 265 270 Lys Leu Gin Asp Met Val Leu Gin Asp Thr Giu Pro Leu Phe Ser Lys 275 280 285 Ile Giu Lys Ile Giu Lys Ile Giu Lys Ile Giu Lys Ile Giu Lys Ile 290 295 300 Glu Lys Gly Glu Giu Ala Leu Ala Giu Lys Ala Giu Lys Lys Giu Lys 305 310 315 320 Giu Lys Ala Pro Pro Thr Gin Giu Asn TIyr Ile Ser Ile Giu Asp Phe 325 330 335 Lys Lys Val Giu Ile Lys Vai Gly Leu Ile Lys Giu Ala Gin Arg Ile 340 345 350 Giu Lys Ser Asn Lys Leu Leu Arg Leu Lys Val Asp Leu Gly Giu Asn 355 360 365 Arg Leu Arg Gin Ile Ile Ser Gly Ile Ala Leu Asp Tyr Giu Pro Giu 370 375 380 *Ser Leu Val Gly Gin Met Vai Cys Val Vai Ala Asn Leu Lys Pro Ala Lys~8 Leu Met Giy Giu MtSer Giu Gly Met Ile eu Ala Vai ArgAs 405 410 415 .99 Asn Asp Asn Leu Ala Leu Ile Ser Pro Thr Arg Giu Lys Ile Ala Gly 420 425 430 *Ser Leu Ile Ser 435 INFORMATION FOR SEQ ID NO:870: SEQUENCE CHARACTERISTICS: LENGTH: 114 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE:- ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .114 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:870 Met Lys Arg Pro Ile Ser Lys Leu Lys Gin Asn Phe Leu Gin Phe Lys 1 5 10 is His Ser Phe Asn Lys His Leu Asp Lys Tyr Ser Leu Tyr Tyr Arg Leu 25 726 Phe Asn Ile Ser Ser Ile Val Ile Gly Phe Leu Ile Ala Leu Phe Ser 40 Tyr Gly Ala Gly Val Ile Leu Val Tyr Pro Ile Leu Phe Leu Phe Ala 55 Leu Ile Ile Lys Pro Ser Phe Phe Tyr Tyr Thr Thr Tyr Leu Leu Leu 70 75 Leu Val Ser Leu Ser Ile Ile Ser Lys Tyr Tyr Leu Leu Ser His Ala 90 Asn Phe Thr Met Lys Leu Ile Met Leu Met Thr Gin Trp Gin Asn Trp 100 105 110 Phe Leu INFORMATION FOR SEQ ID NO:871: SEQUENCE CHARACTERISTICS: LENGTH: 173 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...173 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:871 Met Gly Phe Glu Lys Ser Ile Leu Asp Asn Leu Asn Gly Ala Gin Lys S 1 5 10 Ile Val Ala Cys His Ile Gin Gly Pro Leu Leu Ile Leu Ala Gly Ala 20 25 Gly Ser Gly Lys Thr Lys Thr Leu Thr Ser Arg Leu Ala Tyr Leu Ile 40 Gly Ala Cys Gly Val Pro Ser Glu Asn Thr Leu Thr Leu Thr Phe Thr 55 Asn Lys Ala Ser Lys Glu Met Gin Glu Arg Ala Leu Lys Leu Leu Lys 70 75 Asn Gin Ala Leu Ile Pro Pro Leu Leu Cys Thr Phe His Arg Phe Gly 85 90 Leu Leu Phe Leu Arg Gin His Met Asn Leu Leu Lys Arg Ala Cys Asp 100 105 110 Phe Ser Val Leu Asp Ser Asp Glu Val Lys Thr Leu Cys Lys Gin Leu 115 120 125 Lys Ile Ser Asn Phe Arg Ala Ser Ile Ser Gin Ile Lys Asn Gly Met 130 135 140 Met Asp Leu Ser Val Gin Asp Ser Glu Cys Tyr Lys Ala Tyr Glu Leu 145 150 155 160 Tyr Gin Asn Ala Leu Lys Lys Asp Asn Leu Val Glu Phe 165 170 INFORMATION FOR SEQ ID NO:872: SEQUENCE CHARACTERISTICS: LENGTH: 115 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...115 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:872 Leu Ile Ala Leu Arg Val Thr Ala Trp Lys Val Unk Ala Met Lys Arg 1 5 10 Leu His Leu Ser Val Lys Asp Ala Glu Asn Phe Asp Ala Ile Leu Arg 25 Glu Arg Pro Phe Phe Lys Asp Leu Ile Glu Phe Met Val Ser Gly Pro 40 Val Val Val Met Val Leu Glu Gly Lys Asp Ala Val Ala Lys Asn Arg 55 Glu Leu Met Gly Ala Thr Asp Pro Lys Leu Ala Gin Lys Gly Thr Ile 70 75 Arg Ala Asp Phe Ala Glu Ser Ile Asp Ala Asn Ala Val His Gly Ser 90 Asp Ser Leu Glu Asn Ala His Asn Glu Ile Ala Phe Phe Phe Ala Ala 100 105 110 Arg Glu Phe 115 2) INFORMATION FOR SEQ ID NO:872: SEQUENCE CHARACTERISTICS: LENGTH: 115 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...115 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:872 Leu Ile Ala Leu Arg Val Thr Ala Trp Lys Val Unk Ala Met Lys Arg 1 5 10 Leu His Leu Ser Val Lys Asp Ala Glu Asn Phe Asp Ala Ile Leu Arg 25 Glu Arg Pro Phe Phe Lys Asp Leu Ile Glu Phe Met Val Ser Gly Pro 40 Val Val Val Met Val Leu Glu Gly Lys Asp Ala Val Ala Lys Asn Arg 55 Glu Leu Met Gly Ala Thr Asp Pro Lys Leu Ala Gin Lys Gly Thr Ile 70 75 Arg Ala Asp Phe Ala Glu Ser Ile Asp Ala Asn Ala Val His Gly Ser 90 Asp Ser Leu Glu Asn Ala His Asn Glu Ile Ala Phe Phe Phe Ala Ala 100 105 110 Arg Glu Phe 115 INFORMATION FOR SEQ ID NO:873: SEQUENCE CHARACTERISTICS: LENGTH: 127 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...127 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:873 S Val Phe Thr Tyr Ser Leu Gly Gin Val Phe Phe Ser Leu Ser Ile Gly 1 5 10 Leu Gly Ile Asn Ile Thr Tyr Ala Ala Val Thr Asp Lys Thr Gin Asn 25 Leu Leu Lys Ser Thr Ile Trp Val Val Leu Ser Gly Ile Leu Ile Ser 40 Leu Val Unk Gly Leu Met Ile Phe Thr Phe Val Phe Glu Tyr Gly Ala 50 55 Asn Val Ser Gin Gly Thr Gly Leu Ile Phe Thr Ser Leu Pro Val Val 70 75 Phe Gly Gin Met Gly Ala Ile Gly Val Pro Cys Phe Asn Ser Phe Leu 85 90 Ala Arg Ala Arg Phe Cys Trp His His Phe Tyr Gly Gly Phe Ile Arg 100 105 110 Ala Lys Arg Asp Val Ser Tyr Arg Lys Val Ser Ile Leu Ser Phe 115 120 125 INFORMATION FOR SEQ ID NO:874: SEQUENCE CHARACTERISTICS: LENGTH: 150 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...150 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:874 Met Lys Pro Leu His Phe Ser His Leu Asp Arg Glu Gin Ser Gly Asp 1 5 10 Val Gly Phe Ile Ile Lys Asn Leu Ile Phe Leu Gly Val Phe Ser Leu 25 Leu Gly Trp Leu Asn Thr Glu Tyr Phe Leu Trp Pro Ser Met Leu Glu 40 Leu Lys Lys Ile Leu Leu Glu Glu Asn Arg Lys Lys Ser Val Leu Glu 55 Tyr Ala Gin Arg His Phe Glu Thr Ala Leu Ala Asn Tyr Arg Asn Gin 70 75 Lys Glu Thr Ser Glu Ser Leu Leu Lys Ile Phe Asn Asp Glu Glu Ser 90 Arg Arg Ile Leu Glu Lys Ile Leu Lys Lys Cys Phe Asp Ala Tyr Lys 100 105 110 Ile Lys Pro Leu Leu Ser Gin Asn Pro Ser Gin Lys Thr Gln Phe Phe 115 120 125 Ile Met Ala Arg Ala Ser Glu Leu Glu Lys Thr Tyr Leu Phe Phe Thr 130 135 140 Leu Ile Asn Lys Tyr Leu 145 150 INFORMATION FOR SEQ ID NO:875: SEQUENCE CHARACTERISTICS: LENGTH: 209 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...209 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:875 Met Asn Ala Leu Lys Arg Ala Cys Leu Arg Leu Met Gly Glu Thr Asn 1 5 10 Thr Asp Asp Leu Unk Pro Unk Ser Asp Ala Phe Thr Arg Ser Asp Ile 25 Pro Leu His Ala Lys Ala Met Leu Lys Asn Arg Ile Glu Asn Tyr Glu 40 Gin Arg Ile Glu Ala Ile Lys Thr Lys Gly Val Pro Val Ala Tyr Val 55 Gly Asp Val Val Gly Thr Gly Ser Ser Arg Lys Ser Ala Thr Asn Ser 70 75 Ile Met Trp His Phe Gly Lys Asp Ile Pro Phe Val Pro Asn Lys Arg 90 Ser Gly Gly Ile Val Ile Gly Gly Val Ile Ala Pro Ile Phe Phe Ala 100 105 110 Thr Cys Glu Asp Ser Gly Ala Leu Pro Ile Val Ala Asp Val Lys Asp 115 120 125 Leu Lys Glu Gly Asp Ile Ile Lys Ile Tyr Pro Tyr Lys Gly Glu Ile 130 135 140 Thr Leu Asn Asp Lys Val Val Ser Thr Phe Lys Leu Glu Pro Glu Thr 145 150 155 160 Leu Leu Asp Glu Val Arg Ala Ser Gly Arg Ile Pro Leu Ile Ile Gly 165 170 175 Arg Gly Leu Thr Asn Lys Ala Arg Lys Phe Leu Gly Arg Arg Ile Gly 180 185 190 Ser Val Gin Lys Thr Phe Arg Pro Ser Ser Ala Leu Arg Leu His Phe 195 200 205 Ala INFORMATION FOR SEQ ID NO:876: SEQUENCE CHARACTERISTICS: LENGTH: 234 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...234 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:876 Met Leu Ser Ala His Gin Pro Phe Lys Asn Tyr Pro Asp Leu Ile Lys 1 5 10 Lys Glu Leu Gin Glu His Asn Ala Tyr Ala Ser Val Ala Ser Gly Val 20 25 Pro Ala Met Cys Asp Gly Ile Thr Gin Gly Tyr Glu Gly Met Glu Leu 40 SSer Leu Phe Ser Arg Asp Val Ile Ala Leu Ser Thr Unk Val Gly Leu 50 55 SSer His Asn Val Phe Asp Gly Ala Phe Phe Leu Gly Val Cys Asp Lys 70 75 Ile Val Pro Gly Leu Leu Ile Gly Ala Leu Ser Phe Gly Asn Leu Ala 90 Ser Val Phe Val Pro Ser Gly Pro Met Val Ser Gly Ile Glu Asn Tyr S* 100 105 110 Lys Lys Ala Lys Ala Arg Gin Asp Phe Ala Met Gly Lys Ile Asn Arg S115 120 125 Glu Glu Leu Leu Lys Val Glu Met Gin Ser Tyr His Asp Val Gly Thr 130 135 140 Cys Thr Phe Tyr Gly Thr Ala Asn Ser Asn Gin Met Met Met Glu Phe 145 150 155 160 Met Gly Leu His Val Ala Asn Ser Ser Phe Ile Asn Pro Asn Asn Pro *o 165 170 175 Leu Arg Lys Val Leu Val Glu Glu Ser Ala Lys Arg Leu Ala Ser Gly 180 185 190 Lys Val Leu Pro Leu Ala Lys Leu Ile Asp Glu Lys Ser Ile Leu Asn 195 200 205 Ala Leu Ile Gly Leu Met Ala Thr Gly Gly Ser Thr Asn His Thr Leu 210 215 220 His Leu Ile Ala Ile Ala Asp Leu Val Gly 225 230 INFORMATION FOR SEQ ID NO:877: SEQUENCE CHARACTERISTICS: LENGTH: 394 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1 .394 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:877 Leu Met Trp Leu Lys Thr Leu Thr Leu Gin Thr Leu Asn Thr Asp Lys 1 5 10 Ala Leu Gin Giu Phe Ser Lys Thr Met Glu Ala Phe Lys Thr Lys Leu 25 Ile Gin Ser Ala Asn Asp Val His Ser Giu Thr Ser Arg Ala Ala Ile 40 Ala Asn Asp Leu Glu Arg Leu Lys Glu His Met Ile Asn Val Ala Asn 55 Thr Ser Ile Gly Gly Glu Phe Leu Phe Gly Gly Ser Lys Val Asp Arg 70 75 Pro Pro Ile Asp Ser Asn Gly Lys Tyr His Gly Asn Gly Glu Asp Leu 90 Asn Ala Leu Ile Ser Ser Asp Asn Leu Val Pro Tyr Asn Ile Ser Gly 100 105 110 Gin Asp Leu Phe Leu Gly Thr Asp Lys Asp Lys His Lys Leu Ile Thr 115 120 125 Thr Asn Ile Lys Leu Leu Asn Gin Asn Lys Leu Unk Pro Asp Val Met 130 135 140 Asp Ala Leu Glu His Ser Ser Leu Pro Glu Giu Val Phe Ile Lys Pro *145 150 155 160 Ser Asp Thr Leu Arg Giu Leu Ile Gly Asp Asn Asp Lys Asn Pro Thr '165 170 175 Asn Asp Pro Lys Giu Phe Phe Tyr Leu Gin Gly Ile Arg Pro Asp Gly Se erPe180 185 190 SerSerPheLys Glu Lys Phe Ala Leu Asp Lys Ala Tyr Gin Asn Gin Giu Ser l Thr Lys Vil Se s Leu Leu As LyIl Gly His Ala Tyr Gly Asn Thr Ser Gin Asn Lys Val Val Asp Val Ser Leu Asn Asn 225 230 235 240 Trp Gly Gin Ile Glu Ile Lys Asn Leu Thr Pro Gly Sen Giu Asn Leu 245 250 255 Asp Phe His Leu Ile Ser Ser Asp Gly Asp Phe Asp Asp Leu Asp Ala :260 265 270 Leu Arg Ser Ser Gly Lys Arg Val Thr Glu Tyr Val Lys Ser Ala Phe 275 280 285 Val Thr Asp Arg Sen Leu Sen Gin Val Lys Ala Val Pro Asn Met Tyr 290 295 300 Asn Pro Lys Val Leu Glu Ile Pro Ser Val Phe Val Thr Lys Asp Asn 305 310 315 320 Val Leu Ala Asn Lys Asn Thr Lys Leu Ser Giu Ile Phe Gly Asp Lys 325 330 335 Val Glu Thn Leu Lys Ile Asn Ala Ser Ang Leu Gly Asp Giu Ser Ala 340 345 350 Ile Lys Ile Pro Asn Leu Pro Ile Asn Leu Asp Ile Pro Ile Leu Leu 355 360 365 Asp Val Lys Asn Sen Thr Ile Lys Asp Leu Lys Asp Ala Ile Lys Giu 370 375 380 Arg Phe Asn Asn Giu Gly Gly Cys Gly Asn 385 390 INFORMATION FOR SEQ ID NO:877: SEQUENCE CHARACTERISTICS: LENGTH: 394 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...394 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:877 Leu Met Trp Leu Lys Thr Leu Thr Leu Gin Thr Leu Asn Thr Asp Lys 1 5 10 Ala Leu Gin Glu Phe Ser Lys Thr Met Glu Ala Phe Lys Thr Lys Leu 25 Ile Gin Ser Ala Asn Asp Val His Ser Glu Thr Ser Arg Ala Ala Ile 40 Ala Asn Asp Leu Glu Arg Leu Lys Glu His Met Ile Asn Val Ala Asn 55 Thr Ser Ile Gly Gly Glu Phe Leu Phe Gly Gly Ser Lys Val Asp Arg 65 70 75 SPro Pro Ile Asp Ser Asn Gly Lys Tyr His Gly Asn Gly Glu Asp Leu 90 Asn Ala Leu I-le Ser Ser Asp Asn Leu Val Pro Tyr Asn Ile Ser Gly S100 105 110 Gin Asp Leu Phe Leu Gly Thr Asp Lys Asp Lys His Lys Leu Ile Thr T 115 120 125 Thr Asn Ile Lys Leu Leu Asn Gin Asn Lys Leu Unk Pro Asp Val Met 130 135 140 Asp Ala Leu Glu His Ser Ser Leu Pro Glu Glu Val Phe Ile Lys Pro 145 150 155 160 Ser Asp Thr Leu Arg Glu Leu Ile Gly Asp Asn Asp Lys Asn Pro Thr 165 170 175 Asn Asp Pro Lys Glu Phe Phe Tyr Leu Gin Gly Ile Arg Pro Asp Gly 180 185 190 Ser Ser Phe Lys Glu Lys Phe Ala Leu Asp Lys Ala Tyr Gin Asn Gin 195 200 205 Glu Ser Ala Thr Lys Val Ser Asp Leu Leu Asp Lys Ile Gly His Ala 210 215 220 Tyr Gly Asn Thr Ser Gin Asn Lys Val Val Asp Val Ser Leu Asn Asn 225 230 235 240 Trp Gly Gin Ile Glu Ile Lys Asn Leu Thr Pro Gly Ser Glu Asn Leu 245 250 255 Asp Phe His Leu Ile Ser Ser Asp Gly Asp Phe Asp Asp Leu Asp Ala 260 265 270 Leu Arg Ser Ser Gly Lys Arg Val Thr Glu Tyr Val Lys Ser Ala Phe 275 280 285 Val Thr Asp Arg Ser Leu Ser Gin Val Lys Ala Val Pro Asn Met Tyr 290 295 300 Asn Pro Lys Val Leu Glu Ile Pro Ser Val Phe Val Thr Lys Asp Asn 305 310 315 320 Val Leu Ala Asn Lys Asn Thr Lys Leu Ser Glu Ile Phe Gly Asp Lys 325 330 335 Val Glu Thr Leu Lys Ile Asn Ala Ser Arg Leu Gly Asp Glu Ser Ala 340 345 350 Ile Lys Ile Pro Asn Leu Pro Ile Asn Leu Asp Ile Pro Ile Leu Leu 355 360 365 Asp Val Lys Asn Ser Thr Ile Lys Asp Leu Lys Asp Ala Ile Lys Glu 733 370 375 380 Arg Phe Asn Asn Glu Gly Gly Cys Gly Asn 385 390 INFORMATION FOR SEQ ID NO:878: SEQUENCE CHARACTERISTICS: LENGTH: 102 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE.: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...102 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:878 Leu Lys Ala Leu Asn Asp Cys Met Val Phe Phe His Lys Lys Ile Ile 1 5 10 Leu Asn Phe Ile Tyr Ser Leu Met Val Ala Phe Leu Phe His Leu Ser 25 Tyr Gly Val Leu Leu Lys Ala Asp Gly Met Ala Lys Lys Gin Thr Leu 40 'Leu Val Gly Glu Arg Leu Val Trp Asp Lys Leu Thr Leu Leu Gly Phe 55 Leu Glu Lys Asn His Ile Pro Gin Lys Leu Tyr Tyr Asn Leu Ser Ser 65 70 75 SGin Asp Lys Glu Leu Ser Ala Glu Ile Gin Ser Asn Val Thr Tyr Tyr 90 Unk Phe Lys Arg Cys Lys S100 INFORMATION FOR SEQ ID NO:878:
S.
SEQUENCE CHARACTERISTICS: A) LENGTH: 102 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE:- ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...102 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:878 Leu Lys Ala Leu Asn Asp Cys Met Val Phe Phe His Lys Lys Ile Ile 1 5 10 Leu Asn Phe Ile Tyr Ser Leu Met Val Ala Phe Leu Phe His Leu Ser 25 734 Tyr Gly Val Leu Leu Lys Ala Asp Gly Met Ala Lys Lys Gin Thr Leu 40 Leu Vai Gly Giu Arg Leu Val Trp Asp Lys Leu Thr Leu Leu Gly Phe 55 Leu Giu Lys Asn His Ile Pro Gin Lys Leu Tyr Tyr Asn Leu Ser Ser 70 75 Gin Asp Lys Giu Leu Ser Ala Giu Ile Gin Ser Asn Val Thr Tyr Tyr 90 Unk Phe Lys Arg Cys Lys 100 INFORMATION FOR SEQ ID NO:879: SEQUENCE CHARACTERISTICS: LENGTH: 265 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyiori (ix) FEATURE: NAME/KEY: misc -feature LOCATION 265 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:879 Met Lys Phe Leu Lys Phe Phe Ala Ser Ser Val Thr Leu Asp Glu Lys 1 S 10 Phe Leu Met Phe Leu Leu Cys Asn Ala Leu Ser Asn Aia Tyr Lys Asn 25 Ser Asp Leu Phe Ser Phe Ser Lys Giy Phe Leu Gly Ala Phe Leu Ile 40 Gly Phe Val Val Tyr Tyr Gly Cys Ala Leu Iiq Pro Lys Lys Arg Leu 55 Lys Tyr Ser Leu Giu Trp Leu Phe Ile Giy Ser Gly Ile Ile Phe Ser 70 75 Val Ala Giu Ile Phe Thr Leu Phe Met Phe Lys Met Pro Phe Ser Lys 00085 90 Gly Leu Ile Asp Thr Leu Leu Ala Thr Asn Ser Ser Giu Thr Met Ala 100 105 110 Phe Ile Lys Ser Tyr Lys Asn Tyr Leu Leu Tyr Tyr Ala Leu Ile Leu :::115 120 125 Ile Ala Leu Leu Ile Ala Ile Lys Ile Ile Arg Phe Arg Ala Leu Val 130 135 140 Pro Giy Val Ile Ala Ser Val Leu Giy Leu Ser Ile Leu Thr Ile Gly 145 150 155 160 Ser Val Arg Asn Ile Lys His Leu Thr Lys Asn Asp Ala Ile Leu Lys 165 170 175 Arg Ser Leu Phe Ser Leu Ser Leu Ala Arg Gly Phe Tyr Ser Ala Tyr 180 185 190 Leu Ser Leu Phe Asp Arg Gin Gin Ala Ile Lys Phe Tyr Ser Phe Leu 195 200 205 Asn Asn Leu Tyr Leu Pro Ser Asp Tyr Leu Ser Ser Thr Gly Asp Ile 210 215 220 Ser Asn Val Val Leu. Val Ile Ala Lys Ala Arg Ala Giu Ile Ser Cys 225 230 235 240 Asn Ser Met Ala Ile Ala Phe Leu Ile Ile Pro Tyr Thr Ser Giu Leu 245 250 255 Ala Asn Giu Arg Giu Arg Giu Arg Giu 260 265 INFORMATION FOR SEQ ID NO:880: SEQUENCE CHARACTERISTICS: LENGTH: 363 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .363 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:880 Met Lys Phe Phe Leu Leu Lys Lys Phe Ser Unk Phe Leu Asn Thr Gln 1 5 10 Tbhr His Phe Asn Leu Lys Arg Leu Asn Ala Sen Ser Phe Leu Leu Giu 2S Thr Phe Sen Lys Giu Lys His Ala Phe Val Val Asp Leu Ser Ala Pro 40 Tyr Ile Gly Leu Ser Lys Lys Pro Pro Giu Sen Val Leu Lys Asn Thr 55 LuAla Leu Asp Phe Cys Leu Asn Lys Phe Thr Lys Asn Ala Lys Ile 70 75 *Leu Gin Ala Asn Val Ile Asp Asn Asp Ang Ile Leu Giu Ile Lys Gly 90 Ala Lys Asp Leu Ala Tyr Lys Ser Giu Thr Phe Ile Leu Ang Leu Giu 100 105 110 Met Ile Pro Lys Lys Ala Asn Leu Met Ile Leu Asp Gin Glu Lys Cys *115 120 125 V\al Ile Giu Ala Phe Ang Phe Asn Asp Ang Val Ala Lys Asn Asp Ile 130 135 140 Leu Gly Ala Leu Pro Pro Asn Ile Tyr Giu His Gin Giu Giu Asp Leu 145 150 155 160 *Asp Phe Lys Gly Leu Leu Asp Ile Leu Giu Lys Asp Phe Leu Ser Tyr *165 170 175 Gin His Lys Giu Leu Giu His Lys Lys Asn Gin Ile Ile Lys Arg Leu 180 185 190 *Asn Ala Gin Lys Giu Arg Leu Lys Giu Lys Leu Giu Lys Leu Giu Asp 195 200 205 Pro Lys Thr Leu Gin Leu Giu Ala Lys Giu Leu Gin Thr Gin Ala Sen 210 215 220 Leu Leu Leu Thr Tyr Gin His Leu Ile Asn Ang Arg Giu Asn Ang Val 225 230 235 240 Ile Leu Lys Asp Phe Giu Asp Lys Giu Cys Met Ile Giu Ile Asp Lys 245 250 255 Ser Met Pro Leu Asn Ala Phe Ile Asn Lys Lys Phe Thr Leu Sen Lys 260 265 270 Lys Lys Lys Gin Lys Sen Gin Phe Leu Tyr Leu Giu Giu Giu Asn Leu 275 280 285 Lys Giu Lys Ile Ala Phe Lys Giu Asn Gin Ile Asn Tyr Val Arg Asp 290 295 300 Ala Ala Giu Giu Ser Val Leu Giu Met Phe Met Pro Val Lys Asn Ser 305 310 315 320 Lys Ile Lys Arg Pro Met Asn Gly Tyr Giu Vai Leu Tyr Tyn Lys Asp 325 330 335 736 Unk Lys Unk Gly Leu Gly Lys Thr Lys Lys Arg Ile Ser Ser Phe Tyr 340 345 350 Lys Tbr Gin Unk Arg Met Ile Unk Giy Cys Unk 355 360 INFORMATION FOR SEQ ID NO:880: SEQUENCE CHARACTERISTICS: LENGTH: 363 amino acids TYPE: amino acid TOPOLOGY: linear MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAIAE/KEY: misc-feature LOCATION 2 .363 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:880 Met Lys Phe Phe Leu Leu Lys Lys Phe Ser Unk Phe Leu Asn Thr Gin 1 5 10 is Thr His Phe Asn Leu Lys Arg Leu Asn Ala Sen Sen Phe Leu Leu Giu 25 Thr Phe Sen Lys Giu Lys His Ala Phe Val Val Asp Leu Ser Ala Pro 40 :Tyr Ile Gly Leu Ser Lys Lys Pro Pro Giu Sen Val Leu Lys Asn Thr s0 55 60 *Leu Ala Leu Asp Phe Cys Leu Asn Lys Phe Thr Lys Asn Ala Lys Ile 70 75 Leu Gin Ala Asn Val Ile Asp Asn Asp Arg Ile Leu Glu Ile Lys Gly 90 Ala Lys Asp Leu Ala Tyr Lys Ser Glu Thr Phe Ile Leu Arg Leu Giu *100 105 110 Met Ile Pro Lys Lys Ala Asn Leu Met Ile Leu Asp Gin Giu Lys Cys 115 120 125 Val Ile Giu Ala Phe Ang Phe Asn Asp Arg Val Ala Lys Asn Asp Ile *130 135 140 Leu Gly Ala Leu Pro Pro Asn Ile Tyr Glu His Gin Glu Giu Asp Leu 145 150 155 160 Asp Phe Lys Gly Leu Leu Asp Ile Leu Glu Lys Asp Phe Leu Sen Tyr 165 170 175 Gin His Lys Glu Leu Glu His Lys Lys Asn Gin Ile Ile Lys Ang Leu 180 185 190 Asn Ala Gin Lys Giu Ang Leu Lys Glu Lys Leu Giu Lys Leu Glu Asp 195 200 205 Pro Lys Thn Leu Gin Leu Giu Ala Lys Glu Leu Gin Thr Gin Ala Ser 210 215 220 Leu Leu Leu Thr Tyr Gin His Leu Ile Aso Arg Arg Giu Asn Arg Val 225 230 235 240 Ile Leu Lys Asp Phe Glu Asp Lys Glu Cys Met Ile Glu Ile Asp Lys 245 250 255 Ser Met Pro Leu Asn Ala Phe Ile Asn Lys Lys Phe Thr Leu Ser Lys 260 265 270 Lys Lys Lys Gin Lys Ser Gin Phe Leu Tyr Leu Giu Giu Giu Asn Leu 275 280 285 Lys Giu Lys Ile Ala Phe Lys Glu Asn Gin Ile Asn Tyr Val Ang Asp 290 295 300 Ala Ala Giu Giu Sen Val Leu Giu Met Phe Met Pro Val Lys Asn Ser 305 310 315 Lys Ile Lys Arg Pro Met Asn Giy Tyr Glu Val 325 330 Unk Lys Unk Giy Leu Gly Lys Thr Lys Lys Arg 340 345 Lys Thr Gin Unk Arg Met Ile Unk Gly Cys Unk 355 360 Leu Tyr Tyr 320 Lys Asp 335 Phe Tyr Ile Ser INFORMATION FOR SEQ ID NO:99S: SEQUENCE CHARACTERISTICS: LENGTH: 822 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .822 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:995
S.
S
S
.4 S
S
S S S S *5 S *5*5
S
S.
S S
GACGCACGTA
ACTAGAGGAG
T1ATGTTTAT
AAGGGAGAGG
GCTATTAAAA
AGGGGTGTAC
GATATACCTA
AAAGATGAAA
GCTIATATCA
AAAGCGACAG
CTAGGGGATA
GCTGTTGTCT
TCAGAGCCTT
ATGCAAAAAG
GTTTCTTTrT
TAGCGATGGG
TTAGCACCCT
AGGCTTATAA
ATGGTGAGTC
CTAAAGATI'A
GAGGGTATAA
AGAAAGCGGT
ACTTAGGCAT
AATGTTAG
TTTATTATAG
ATI'ATAAAAT
ACCGGTATGG
CATGCGAFI'T
AAGAFI'GGTA
ATACGCAAGC
TGGTGACGAA
TAATAAGGAA
GCTTGCTrAT
CAAGAAAGCG
CAATTTGGGC
GGAATATT
CATIGTATATG
AAAAGCGATG
CGGGAATGAT
GGCGGCCGAT
GTrAGGCGTG
TGACATTGAT
GCTATGGCAT
AAAITAGCTT
CACCTTGAGC
TATGAGCGAG
AT'CTTrAG G ETGAATA'T
GTGATGTATA
AGAATAGCTAX
GAGGGCAGGG
CATAAGGGCA
CAATI'GGGTA
GTGAGTTCTT
GAAAAAGATA
AAAAATTGTA
TATGTTTGAT
TAAAGATI'TG
AAAAAGGGAA
CGGCTI'CTTT
GGATCATGTA
TCCAAAAAGc
AAGAGGGTAA
CAGAGAA3AGG
GAGTTCCAAG
ATGTGGAAGC
TTGAGCCGGA
CTAGAGCTTA
AAAAAAAGGC
AG
CTTAATTAAT
TTTGGTAGGT
TTATAITTAT
TATAAGAGC
TGAAAATGGT
TGTrGATAAC GGGAG ITCCT
TI'ATACTAAC
TAACTATGCG
TTATATTCTC
CAAAGATAAG
TGAAGGGT1'G
TGAAGAATAC
INFORMATION FOR SEQ ID NO:996: SEQUENCE CHARACTERISTICS: LENGTH: 447 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO jvi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .447 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:996
ACGATGAAAA
GCTACCCCTr
AACATCCTCA
GACATTTT
TATAGTI'TCA.
CAAAATATCC
AGCAAAAAAG
CTCATCC=I
ATACATCGTC ATCAACGACT TAGGCAAGGG AGCGATI'AGC AACAACTCAC CCAAAAACAA CTGATGGCGT TITATTGGAC CCGGTGAAGA TGTGTGCGAA TI'CAAGCITG CTrGAArTA CC TTI'AAA CCATAAAATG GTGAAGATGA AAGCGTT
TTAACAATGA
ATCATTAAAA
GACTTCACCC
AAAGCGTTAG
ATCCAATGCC
GGGGCTAGGC
GATTTGAGCG
ATGACACCAT
TCAGCGGCCA
CCAGATACGC
TGAT'FrATTT
ATGGAAGCCC
TCGCTAAAGC
AGATTGAAGC
TGCCGCTATC
TAACGCCCTA
TTACGTGTGC
CAAAGCCCCC
CCTTTTAGCG
GGGGGAA'TI'
GAGCG'ITCAG
INFORMATION FOR SEQ ID NO:997: SEQUENCE CHARACTERISTICS: LENGTH: 804 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .804 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:997
S.
S
5.55
S
S. 54 55 S
S
S
S. S
S
*555 0* S
S
AATCTAXTT
GAGCCGATGA
GGTrATGAAG
AAGCCGGTAT
GTGGCAGAAA
TGAGCGAAG
ATTGGCTCTr
GCCCCTCCCA
CTTAITAATG
GGCTGTAGCT
ACTTCCACAC
GCGGAGCTrG
AATITAGTGA
AACTTAATGG
ATCGGAGCTC
TTGAATACT
ACAAAGAGAC
TGTTAGAGCC
TCACGGAGCC
TTTTAGCGGA.
GCATGACGAA
GTCAAGCACG
AGGGCTATTA
TGTGCATGGG
GGAATTGA
GGGCGGCGTG
GTGAAAAGCT
AGAATTTCAG
ACAAAGGAGC
GAAATCCAAT
TITrGAAAAAA
AGATAGTA.AC
TATTGGCA
TACGACCGGC
TATrGGGCAT
CCTTGGGTA
TGCGATTTT
CAATCAAGCG
TAATCGTATG
CGCTI'TACTA
AGAGAGCCAA
GtTC
GCAGCCGC'±T
ATCAAGCTCA
CGCAGAGATG
GCCCAATACG
TGCCCTAATG
AAAAGACCCC
TTCAGAGCCT
GTGCCACCCA
GGGGCTGCCG
AGGG'ITAGGG
GGTAGAGGGG
GGGAGGATCC
AAAGACAAGA
GCGTGGTGCG
TTGATGAGAT
CGATGCAAGC
CCGCTGTCAT
ACCCTGATGA
ACGCTATTGA
TTGGTGAAAT
GTAAAATGGA
GGGCAAGGAC
ATAATGCGGT
CTAAAGTGTA
CCACTAAAGA
TCTATCGCTA
rITGAATAAA
GATTGCAAGC
TTGGGTGGAT
TGAAA'ITGAT
CGTCGCTACT
TGAAGTGTFI'
CGTTAAAAAC
CGAACAAGAG
TGAAGTACCA
CGTTTrCT
TI'TGGGCAGT
AGAATACATG
CATGAACTTT
INFORMATION FOR SEQ ID NO:998: SEQUENCE CHARACTERISTICS: LENGTH: 1290 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1290 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:998 AAAATGC CAT
GTTIGTATGA
CAGCAAATCA
AATCAAATCT
ACTTATTACA
GCTAAAGAAA
GGCCGTTATG
GATTTCAATA
TATAAAGAAA
GTGGAAAATT
AAAACGCAAT
ATIGATI'ATA
AITGAATACG
AACGTI'GAAG
AATTTTAGAA
ACTAAAAGCG
CTTTCCACAC
AAAAAT'ITAT
TCCTTATTAG
GAGATGTT
GACAATCAAG
ATAAAAAACG
ACGCCTTAAG
TAAATI'GCA
TTAAGACAGA
'FFICITFGT
AGGACATCTT
GCTATGAGCC
CGATTI'TAGT
TCCAAGTCTT
TTGAAAAAGA
TGCTCCAAAA
TAGAAAATCA
AAGAGCAATI'
ATGATGATGG
TCAAACACCA
AACATGATGC
GTCTGATCCT
AAATCAATTT
TCAFI'GTCAA
AGAGCGATT
TAAACACGCT
TCCGTI'ACCA
AAAGCGAAAC
AAAAAGATFI'
TGCCAAAAGC
GCCTTGCTCT
ATCCCAATAC
AAACAAACTC
TAAGATTGAA
GATGAACACC
TGACAGCGAT
AAAATTCCCT
TACGACTATC
TACCGAGCTT
AGGCATGCTC
CCTGATAGGT
AGAAAACATT
GTTFIAAA
TI'CTCAAATA
CAACCCCTCT
TGCCTTGCAA
AAGGCATGAT
AGATCCGCAT
CAATCAA.XT
AAAAAAAGAA
TCAAACGCC
TATCTGTTFI'
TTGGAGTGCT
GATGATAACA
AACCCCGTAT
TTAGCGAT
CTTAGCGT
GAAGAAAGCC
TTI'ATCATCG
AATACCCCTA
TCTTAAGCG
GCAACTTTCA
GAACGC LTGA
TCTTACAAAC
AAT1'CTACCT GGGCTrAG
TTACTCTTGC
AACAGCGATG
TGGGTGAATI'
TTTAAAAAGT
TATCAGGCTT
TTI'TATTGTT
CTCCTTTGCC
TGAAAGACTT
ACCAAGATGA
TCATCGCTTC
TACTGCCTAA
ATITGAACAC
CTGAAAAATT
CTTTATTGAC
CTTATGTGCC
AGCGCTTGTA
TTAGCCCTAA
GGCAAATCAC
AAGCGACCAG
TAATTFTGAA
AGTATAAGCC
TCACCCAGCC
AAACGCTGAT
ATTICCAGCGC
CITTTTCAAGA
TAGGGTATTC
TTTTTTAATT
CCCAGCGCAC
GATGCTGCAA
GAGCCTTAAA
TCAAACTCCA
AAAGGTGGTG
CAGAAACAAC
AGAAGAAACC
TAAAGAGGGC
TACGGTGAAT
TrrTGGGGGG
TTCGCCCGTG
GGAGTCTI'A
TTTITCTAAA
CACCCCTACC
TCTTAAAATC
TAAAGACAGG
AGAATACGCT
GATAGGGCTA
GAGTTTGGAA
TTTTGAGCCG
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1290 *9*9 9 99 9 9* 99 9* 99** 9* 99 9 9 9* 99 9 9* 9* 9 .40 004 0 INFORMATION FOR SEQ ID NO:999: SEQUENCE CHARACTERISTICS: LENGTH: 1458 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: MHelicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1458 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:999
TAITAGATA
TATGCGAGTG
TTGTTTGTTT
GGGGTAGCGG
GGGATITCC
ATTATTTGAA
GGAAATTAAA
CCATICTTTA
AATCTGTITC
CTACAGCCAC
TACTITTAT
AAGGAI'GGT
TAATCAAAGC
TAAAGTGGGG
CTTIGTAACC
TTTAATGGGT
GCGGTGTTAA
CCTTIATI'GG
?I'rAACCATT
GCCACGATCA
TITTAAGAAA
AATI
9
TCAAAA
CTI'TTGATI'A
CCAAACTCAA
AGCTTCAAGT
GATAGACTAT
ATTACCCTTA
TAAGTTTAGT
TI'CCAAAGAA
GGAZTCCAAT
CTGCTCCCTA
GCGCTCGCFI'
T_'AGAACTT
GACTCCCTCA
TTTTATI'CTT
TFTATGAGFI'
TTAAAATGGT
TATGCCCCTA
CAACTCTATT
ATTTACGGAG
GGGTTAAGGG
GATGTGTATT
CGCTTTGACT
AACGCAAGGA
TATGGTGGGG
GGGGGGGTGT
GCGAGCGAAA
GATGTGAATT
ACCGGCCCTT
AGCATGAAAT
AAAACAT'GA
ACGATTCCAC
TTTACCTCAT
TAGAATCTGA
ATGGCGATAA
CCTACACACA
TTAGCTCTTT
TITGTAACTGA
TTI'CTAGCAA
CGCCCGGTGT
CTCAAACCAC
GGCGTAACTC
ACAACGAATT
TTGGCTGGTA
TCTTCAGTAA
ATAGAGGGTT
GATCCATCAA
TAGAATACTA
TCAACAAAGC
TCUTFI1a
AAAACACAGC
CAAAACGCTC
AGGGCGTTGG
CGCTCACACC
ATTCCACCTA
GGGTI'TTGAA
TGGGAGGGCG
AGATGGCAGA
GCATGTTCAA
TAAAATCCAT
TAT1'AATGTG
TAAGATTGGC
TAAC TTGGC
TGGTAACCCC
CGCTATTACC
TTTATGGGGT
CTTGAAC'ITG
TGTGGTCAGC
CTTTAAGGCT
TTAAAAATAG
ATAGACCAAG
TGGGGGTT
CGTAATTATG
AAATTAGGGC
CTGGATTATA
TTGGCTTTG
AAAGAAG=IT
GTCATGCCT'
ATTGATAGCA
AT'FTTCCCTG
GAGTGGGGCG
TTIGGTTATT
ATCCCTTTTA
GCAGACGCCG
A TITAGGCA
GGCTATAAAT
ATGCACAACG
GACGCACAAG
GCGTTGGGGG
CCACGCATCA
TAGGCAACGC
TGCTGTATAA
GTTATCTCTC
AAATCAATTC
GGCAATGGAT
ATGATGGCAT
TTGCTTATT
ACCCGAAATT
TTTATGCTAA
CATCGCTTTTL
ACCAAAATT
AT1'ATAGAAA
TTTCTGGGTA
GATACACTTIA
GGGGTTCTT
GCTATAGA'TT
ATAGGAGTAA
GA'FTI'AGGA
AATCTATGGC
TCCTTGGAAA.
TTCCTATCTG
TAACATGGAT
TAAAATAGCG
ACGGGATTGG
CCATGCCGCG
TTCGCCTAAG
CAAAGGCTTA
AGATTTATAC
GATCCACCAA
TGOCAACGCT
TAACAGCGT
TGTCITTTGGT
TGCCACTAGA
TGCTAGAGTT
AGACTATCTC
CCTTATGGTT
360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1458 9*e* INFORMATION FOR SEQ ID NO:1000: ()SEQUENCE CHARACTERISTICS: LENGTH: 762 base pairs TYPE: nucleic acid STRANDEDNESS: doubl.e TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 762 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1000 GTF1'ACGCGG
GAAAACGCT'
CGTTCATGCA
TFI'GTGCCGA
AGCATI'GTGT
AGCTCTCTTIG
AGAATCTACG
GCGTTTG=I~
CCTGCTTITAG
GATCAATCTA
GTTAAAAGCA
AATCAAACCG
GATGAATTGG
GGTTGGCTAT
TTGAAAAATT
AAGAAATCGC
TTCTAACCTr ATGCGCTI'rT
TCTI'AAAAGC
CCCCTTTATT
TTAATCGC
ATGAGGGCGA
AAGATCTCAT
TTGTCGCGCG
ATACTrTAT
TI'AGAAAAAA
CGCTATAGGC
GAGCGCTAAC
CGTTTCAGTG
ACAGGGGTI'A
AGGCACI=A
CACGCCCCAT
GGAATTFF
AAGCCTTITCT
TGTGGT1TG
GTTAAACATI'
CACAGGGAGC
?I'CTTTCATC
TCATGGATIC
ATGCTCATTG
ACTAAAACCA
GTGAGCGGGG
GAGGGCAAGA
GTI'CTATCCA.
AGCGAAACCT
GTGCATAACC
TTATrCCCT-r
AGCGTGGAAA
GAAAGCGCGA
GATGAATTGG
CCTAAAAAAG
TFI'AAAAGAC
ACTCATCTGT
CTAAACTCCA
TGGTGATCAT
TCGTrAGGCC
TCACTATCAT
TTIAACGAG
CTAAAAAAGT
TTGTGGGGAA.
CCACCCCCTC
TIAAAAAGCA
GGCTOGATIT
AATGGAGCGT
Tr
GGTAGTGGTG
TGCAATCTAT
TAT1'GTGT1T
'TTAGCGCAA
TCCTGTAGTG
GITrrrAAAC
GATFITAGGA
GAATTTCATG
TATTTCCTIA
TGTCAAAGAA
AGGGGGTITG
TAAAACCAAA
INFORMATION FOR SEQ ID NO:l001: SEQUENCE CHARACTERISTICS: LENGTH: 471 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO jvi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .471 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:100l
TGGTTGTFI'C
ATGCGTATAG
GCGGXTI'AG
CATAAAAACC
AAAAATAGCG
AAAAGCGATA
ATGCCGATTG
AGCAAAAAAA
TAACATGCTA
TAGAAATTT
AAACCGGAAC
ATGGCTCAGA
GATI'AGAAGG
AAAAGFFFI'A
TGAATTI'CAA
CCCAATACAT
TGGTAGTGTG
ATTI'CTTGTA
CAAAAACGAC
AACCGAGACT
CGTGGATTTIA
TAAACAACTC
TAAAGCCCTA
GGACGGCGGG
ATAAAGAAAG
TCGTTTGTGG
AAAAAGAGCG
AAAAACGATA
GAAAAAAGCC
GCTAAAAACA
TC'FITTGGGC
TTGATGATGC
GCTATATAAG
CGTATAGTAG
GTAAAAAAT
AAAAGCTTTA
CTAACCTTAA
ATATCGCTGA
CTI'ATIT1GA
ACATCCGTTT
AGGAGATCT
TGCGTTCGCA.
TI'ACAAACTC
TGAITTCACT
AAGCCATAAA
AGGGGTGAGC
AAGGACTAAA
T
9 *99e .9 *9we S S e.
S
S. S S S S. S S S. S INFORMATION FOR SEQ ID NO:1002: SEQUENCE CHARACTERISTICS: LENGTH: 675 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .675 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1002 4* a9
CCGAAAATTG
GCCTTAGTGC
GTTIGAACG
AGCCATAAGT
CAAGATTTGA
AAGGAAGTGT
GCCTTTAGCG
ATGATGATTA
CTITIGCCTG
ATTTCTTATI'
AAGATCATGA
TGGAGCGAAG
CACCGCTTGC
GAGCAACTCT
CGAGTI'TCTT
TCAACGATGA
GCGATAFI'GT
TCGCGCAAAG
ATCCTAAAGA
GGGCTAAGGG
GCACAGCCAT
TGGAAAAAGC
,T7I17TCTTTGC
TGCAT
CATGGCAI'A
TTI'GGGGTGG
AGCCCACT1TC
AAGGCCCTAT
GGCGTATCTC
?I'GTCAAAGG
TTTAGCCAAT
CGAACATGGC
GCCTAGAGTG
GGGCGATAGG
GGTGCTGTCG
AATCCCAAAA
GGCCACCGGA
ATCAAAGACC
CCTATGCCGG
ACTI'CTATT
TGCCATAGCC
TA TTAGGCT
TTGAATGTT
GGATTGAATG
AAAAAGCATG
TTC'ITGGCTT
CATI'CCAGCC
ATTrAAGCCA
CGGTGAAAAC
CGTITTCTCA
TGCCTAAAAA
TGGATI'ATGC
CTCATGCGCC
TCATCAACGA
AAAAAGCTCA
AAAGGAATAC
ACGACTGGAA
CCTATGGATA
TGTGGCGGGG
GGCGAAATI'G
ATTI'AGCGAT
TFI'GAGCGAT
TAAAGATAAG
TGATI'GTCC
TCCGCAAAAG
AAAACAAGTC
TTTAGGGATT
AAGAAAAGTI
120 180 240 300 360 420 480 540 600 660 675 INFORMATION FOR SEQ ID NO:1003: SEQUENCE CHARACTERISTICS: LENGTH: 1143 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 1143 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1003 S S
*SSS
9 5, *9 5 0*e5
S
9
S
ACTTGGCGGT
ATTrGAAAATr TTrACCGGTC GGCCTT TGTG
AGTGAATTCA
AACACCGCTA
ATCCAATACC
CATATGACAA
CCATCCCTTr CATrCTAATT
GAATTATCTA
AAAGAAfTrGA
AGAAAGTCTG
AGGCITFAA
ATAGACAATC
AAAATGCAAG
TTGCCACCA
GAAACGGGAG,
TTIATCAGAC
GGC
ATCAACTAGG
ACAAAAAT
AAAACGATGC
ATCCTACTGC
GAAAAATCAA
ATCCCA'FTAG
CCACACAAAC
ACCTTATAAA
CCCCCATGAC
TAGATAAAAT
TTGrI'AATrC
TTGAAATCCT
TCTATATCCA
ATTTGITr'G
GTGTCAAGTA
AGTTTAAA
CGCACAATAA
TTTTTAAAGA
ACAGCTATTC
CTCATTAAAA
TGAGCACCTT
GGGTAAAACC
CAATCAAGTC
ACTCGATGCC
TATCCGCACT
CAGTTACAGC
CACAACAATA
AATGACTTAT
CGCTCAAACC
TCTI'AAAGCA
ACAATGTTC
AATCAAAGAT
TTGGGGTrT
TCTTTTTATT
AGCTCTGTT
GGAATTTTA
CATAGCCTI'G
TATGCTAGAA
GGCAAAATCC
AAAATGGAAA
AATCTITTAG
AGTCTTCCTC
GACAACCTAA
GAATITGAAC
AAAGACATCA
ACGAAGCCAC
GAATI'TGAAA
AAATGAT'AA
A'FTI'AAACT
AAGCTCTITA
CTGAACATGC
AAACCI IITT
ATGCTACTAT
ATTTGAATAG
AGCTCCAATT
GGCAAAACCT
TATAAAGAAA ATGCGATGTT TTGGAAAAT' TACAATrAGC AACCCTAATA TI'ITAAATGC GAAAACACAC CGCTAGAAGA ATCAAATI'CT TTATrATGGT GATGAAATAG AAAGCGGTTr AAGITAGCTC AAAAAITACA ITAAACGCCA TCAACACGAT TITGAGCITG AAAAAGAAAG AAAGCGCTI'T ATAGGGGTAT
AAGCGTAGAG
CATCAACTIT
TACCAACACA
CGTGAATA'FI
TTATCAAGGA
CCCTCTI'ACT
CGATGATGCT
ITCCTACAAT
AGG'ITTAATC
TAFI'CCTATA
AAGCAAAGAA
TAATACAATA
AAGTCCCAAA
GAGCATTCTT
GCACCATACA
GATI'CAAT
ATCCGATAAT
CGCTTICTGGC
GGAGGTI'AGA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1143 9, .9 S S 99* INFORMATION FOR SEQ ID N'O:1004: SEQUENCE CHARACTERISTICS: LENGTH: 852 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .852 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1004 ACCCATTGTI TAFI'CCTTGG GATTTAAACC ATGGTTATTA AGTAAAAAGG CCGTTGTGGA ATCAGTAAAA GCCTCAACCC CAAAAAACCG GCATTGATI' TTCAAGCGTG, AAGTGTTAAA 'DTGCAGCTI'T TAAGGGCTTA TTAGTGCAAC GAGAAACCGC TTTCAAGTCA F1'AGCCCCAA CGTTATGGCA CAGGCAAAAA ACGGCTAGGG TTGCTAAAAA GGGTTCGCTG AAGATGAAAG GGCAAGGAAG AGTATTACGC AT =TAGTGC GTI'ACAATI'A AACCGCTTAA AA
TGGTAGTATC
CCAATTAGGA
AGACGTTITG
AGAGGATTTC
ATCCTTAGAA
GGGGAGCGTC
TGCGGTGTTT
CCCTAATGGC
AAGCGCTAGA
CGCTCAATTT
CGGAAGCTAT
GCAGGFFI'TT
TAGCAAGATT
CCTATCGCCC
AAAATTGT
AAATACACCA
ATCCAATCTA
TATAACGGGC
GCCACAGGAA
TCTTATGGCT
TCTAATGAAG
GATATTTACA
AAAATGAAAG
GAAGGGCTAT
AGCGCGGAGT
ACTATCGGCG
GCAGCCCCCA
TCTATTGCGA
TAATCCTrAA
TTAAAGACGA
GCAATGTGGG
TTTTAGGCTA
AGATCCCTCC
ATGGGFI'GAA
GCAAAITGAC
TCCCTAGCCC
AAACCTITAAT
ACATAGGGGG
CCTATAACAG
TdGTTATCTT
TTTTAAAGA
TTCAAAACGC
AGAGGGCATT
CTTTATCCCC
CATGATAAAA
TGGATTITCT
TTTGTCCGCT
TGCGACTIT
TACCCCCTAT
CAAACCCACC
TAAGGTGGTG
CAAAACAGGC
CTCTrTTr
AGGCTCGCAT
AATCACCGAA
TTGGAAAA
120 180 240 300 360 420 480 540 600 660 720 780 840 8S2 9.
*0 INFORMATION FOR SEQ ID NO:1005: SEQUENCE CHARACTERISTICS: LENGTH: 417 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAMEIKEX: misc-feature LOCATION .417 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1005
GATAAAAAAA
CCATTAGGCC
ATCTCTCTI'A
TCAATCCTI'A
TTCTATGGCT
CTI TACAACC ATCACT1'TAG
TACTTTI'AAT
ATATTTGGCT
ITGTCTTI'AA
TTGCGTTATT
TTCITTTATGG
TTI'CAGTGAA
ATCACCGCAT
TATI'CAAGGA
GAGCGCTITA
ACTTAAAGGG
TGTGTATAAA
CTTGTGGCCG
GTCCGGGTAT
TITAGTGATT
AAATTT1ATGG
GTCGCACTIT
TATAGCGCTG
ATGCCTGT'C
ATC!GCATGGA
TTTGAAATCT
TGATTGGCT
AATTTCATCA
CGCCTATTGC
GGTFFFIAAG
AAATGGTGAG
'ITGTGATCGC
TAAAAGAAAG
TTTGTTTGGC
AGTTTATGAC
GCTCTF7i-171 CTrAGCGCTT
CGCGAGTTI'
TGCGA'TTTT
CGTTCAGTCC
TCATT
120 180 240 300 360 417 INFORMATION FOR SEQ_;D NO:1006: Wi SEQUENCE CHARACTERISTICS: LENGTH: 291 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genornic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .291 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1006
CCTAAACCTA
AACAAGCTTT
TTAI'TCGCAT
CTCGCTCCA.A
GGCACCGGCT
AAGGGGTT'G
TTTCATACCC
ACCCGCTCAA
FFIT1TAACGC
CTAAAATTAA
CCCTAAAAAT
TAAACCCAAA
ACCCCACGAA
TATACACAGC
CCCTATAATC
CTAATGAGTA
ATAAAAGCGA
ATGGCCTTAT
ACTAACGCGC
ATGCCCATGA
AAAGAGCGAT
CAAACACAAG
TAGCGCTCGC
TCAACGCTAT
AAATACAAAA
CCGTTTCCCT
CCACACCGT
TACCTCACTG
CAAACCTGAT
A
120 180 240 291 INFORMATION FOR SEQ ID NO:1007: SEQUENCE CHARACTERISTICS: LENGTH: 1596 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1596 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1007
AGAAACGT
TTGTTI=TC
TTGGTGGATA
AAAATTTACA
AAAAACAAAA
TTAGAGTCCC
GAGCGCCCCA
ATFI'CITTCA
TTAGGAGAAG
'FTGGATAAAA
TTGCAAGGGG
GAAGCTATAA
ITTI'AGCGG
TACATTGAAA
AGCGTGATCG
GTrFI'AGGCT
CTCGGGTGGT
GCTAAGGGGA
ATTTTAGAAG
TFI'GTGCCTA
AAAACGGTTT
TCTAAAATTG,
AAACAGCTCA
TGCTTFGA
TATGCCACCA
TTAAAGGTGT
AAGCAGAAGA
AAAAACTCGC
ACCAAATITA
AAAGCAAGGA
AGCAAJA.AAT
ATATCCCCAA
TCAAGAGCAT
TTTTAAAGCT
GCGCGAA.ATT
CTCAAAACAT
GCATI'GTCAA
CCCTITTGAG
ATAATGAGCG
TTTTAATCT
T1'GCGAGCGC
TTATCATT
CGGATATI'IT
ACGTAACCTT
ACA1AT1ACAT
GGGATGGCGT
CGCTCAATAT
ATAAAATGCG
TGCCTGAAAA
TGTCTTTAAG
TAGAAAAATG
TAAGAGCCAA
CAAAGACGAT
TACTGAAAAA
T1'ATI'AAAG
GTTTGAAAGC
TATCCCTAAT
GCGTTTAA.AG,
TTIAGATCAA
AAGCGATGAG
TCTAAAAACC
ATCTCAAGT'
CGTGGTGTTT
CGTCTATACC
TC7r'I17I'cT
GGGCTTAGCG
GAT1'GGGGGG
TATTGGCGAT
TACCACTTAC
TTTCACCACC
GGATTTTGC
CGCTACGGAA
CGACCGGTAT
TAACGGGATA
GAGCAAGAT
GCATTAAGGG
GAATTATCAT
AACGTGTGGT
GAGAGCGTGA
ATI'AGCACCT
TATGGGGTCA
ATCGCTAACC
CATGAAAATC
AAACACCAGC
A'rTTATCAAA
ACGATCGGGA
AAAAACCAGC
GCGTGGATT
GTGAATAAAG
TATTTAGAAA
ATTGCGATGA
AGCGTGCATG
GTGTTGGATA
ACGAPLTAACA
ATGTI'CGCTA
GITACATITG
TTGTCTAAAG
TCITTAAGGA
AAAATCTCGG
GTGGCTGAAA
TATI'ATTATT
CTATACAAAA
TGAAAAAATT
GGCAGGAATI'
TAGAGCATAC
ATCCTITTTAA
CTATTGCGAT
TTAAAATAA
Trr1'AAATCA
CTCAAGCCAA
TITI'CCAAAA
TTTTTAAATT
TAAAAATCAT
CCATTAACTT
ACG=IACTTA
AGGAT1'TATT
TGGGCGATAG
TITCTATGTl'
GGAGAGCGGG
A'ITACAGCCA
AT1'CTGATTI
AATACACGGA
GTITGAGCGT
TGTGGTATCA
TTGTTGAAGC
CTITITG TT
ACAAATGGCT
TGAAAACTAT
AAGGCGCTI'A
CTTAAAGGCT
GGACTTGATA
CATI'GATGGC
CCAGACTTCT
GTGGCACGCT
ACGCTI'AGAA
AGACAGCGAT
GG'TI'ATGTG
TrCCAGTAA
CGTGAATGTG
CITGGTAACG
CATGAGCTTG
GGTGCGTATC
GCACATI
1
ACG
CCGAATI'ATC
T'TTGGGATG
TAAAAAAGCG
TATTACCTAT
CAAGCCTCGA
AACCAATICG
CTTTTTGAAA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 GAAGAAAATA TCCATATCGC TTATACGACC AGCAAGCTGC TTAAAGTGGA TGCTGATGCT CTAGGCGATG GTTTTGGGAA TAAAAGGGAA CAAAAA INFORMATION FOR SEQ ID NO:l008: SEQUENCE CHARACTERISTICS: CA) LENGTH: 104. base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1041 (Xi) SEQUENCE DESCRIPTION: SEQ ID NO:1008 1560 1596 S. S.
*SS*
S S. S
S
S
CGGAGTGAAA
TTGGGGGAAC
GTGGCCGGGT
TGCGTGATAG
AACGCCTITG
ATAAGCGATA
ATCCCTACGA
ACGCCTTATG
ITAGCTTI'IT
AAAATGGCGG
GA'ITGTTTAG
GATGAAAAAG
ATAGAAAACG
CGCATGGCTA
ATAGAAAAT
AAATTTTACG
TTGCCTAAAG
AAGGTGT'AG
GAATGCAAGA
TGCCTGAAAT
TGCATTTGCC
AGTCCGGGGA
AAATGCAATT
TGGTGGGGTT1
CTI'TACTCGC
GCAAGAACCT
TAAAAACCCT
TGTGTTTI'GA
AAGAAGTAAT
AGCGAAACAT
AGACCAATTA
ATGATI'AGC
TATI'GAAAAA
AACGCTTGTT
GTGTI'GGAGC
AAAAATGGCA
AATCTTAATC
AAAATTGAAA
CTATTFTGTTA
AAAATACAAA
AAACCGCCAT
TGCGAGCAGT
TCAAGTGGAT
AATCGGATCG
TGAAAAAAGG
TAAAAACT'G
CTTTCAAAGC
CAGGGCTGGG
CGAGCGATTT
CCTTTCTTTA
ATTTGATCTG
TTTAGACAAA
GTTTGAGAT
T
CCTTTAAAAG
CAAAAAGCGC
GAGCGCTI'GA
AATTTTCATT
TCTTTAATGA
ATTTATITCA
GCGAGCGTGG
TTCCACCAGC
GAATTI'CAAG
GTAGAAAGAT
GTCAATATCA
TTGAACTATG
TI'GCATGGCG
GGCATGCTCA
ATATTCAATI'
AAAAGCGAGA
GCCTCTCATA
AAAAAAGCTA
TCATCATTAG
ACGCCTITAGA
CATI'AGAGCG
TAGCCCT'GG
GGGGGATTGA
GGGGGAAAAC
CTAAAGCGGT
,CGGGGGTTGC
TAGAAACAAA
AAGCTCAAGT
GGCATACCTI
AAGCGATCGC
ItTTAAAAGA
ACCAAATCAC
ACCAAACCCT
TCCCTAAAGA
TAAAGTGITI'
CGATAGCATC
AGTCAGAGTG
GATTTTAAAC
TGGGGGAGTG
TTTTA2TIAAT
AGGGATCAAC
TTATATGGAT
TGAAATCAT'
GGAITTAAAA
CGTI'GTTCAA
TGGCATGCTG
TATTGGCATG
ATACGAACGC
TGATA LTCAA
AAAAI'CATT
AACGATITA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1041 INFORMATION FOR SEQ ID NO:1009: Wi SEQUENCE CHARACTERISTICS: LENGTH: 588 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEy: misc~feature LOCATION .588 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1009
AAATCAAAGA
AACCTCACCG
TTGATCCTA
TCCAGTAAGG
GAAAATTATT
GTTTATAAAA
AA.AATCTTT
TTGCCCAAAC
AATGCATTCC
GAAGTCAAAG
GTATGAAT
CTCCCTI'AA
CTI'TTGCT'
ATTI'ICTTTA.
TTTATGCTAA
TCCCAGAGAG
TAGCGTI'GCT
GATI'GGACAC
AACGATACGA
AAGAATI'ACT
AAGGAGAGGG
ACGCATCAAA
GTTGCTTT
TGTGATCCAG
CAAGGGTCTT
CATGCCCATA
-17'ITTTT"CATT
TAAAATGAGT
TGCGCTAGGG
AGAAGTGATA
AAAATCATGC
AACCGCTCGC
TTAATCTTAA
TCTCACCCTA
TATAAAACCA
GAAAAACGAG
TCTAGCATGC
T1TAGAGAGCG
GTGCGTTTTG
GATTATTTAA
CGTTTTCTAA
TTGTI'TGGC
GCGATGTITC
AACAAACTCT
ACAAAGAAGC
AAAGTTrA.AG,
TTTTI'GGGAT
CGCACAAAAA
AAGACATTGC
AAA1AACCC
ATITTTAGAA
GTTAGGGTTI'
TAGGCTCATA
AATTGAAGAT
cTTTTTAAGG
CAAGGTTI'CT
CTTTTGGCGT
CGAATI'AGAA
AGGGGTGAAT
a INFORMATION FOR SEQ ID NO:1O10: SEQUENCE CHARACTERISTICS: LENGTH: 537 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genornic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .537 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:l0l0 ATGAAACCAT TGCATTTTTC ATTAAAAACC TIATFITIT TTTCTATGGC CTAGCATGCT AGCGT TTI'AG AATACGCGCA AAAGAAACCA GCGAATCTTT GAAAAGATCT TAAAAAAATG CCCTCCCAAA AAACCCAATT CTITTTTCA. CCTIAATCAA ATT='CTAAAG ATAGCGACGG
ACACCTGGAC
AGGGGTTTT
GGAATTAAAA
AAGGCAITIT
GTTAAAGATT
TTITGACGCC
TTTTATCATG
CAAGTATTTA
GTTGTTGGTG
AGAGAGCAAT
TCC'ITATI'GG
AAA.ATCCTTT
GAAACAGCCC
TTrAATGATG
TATAAAATCA
GCTAGAGCGA
CCGAGCGCTC
CAA'TrGGCG
CAGGCGATGT
GTTGGTTGAA
TAGAAGAAAA
TAGCAAACTA
AAGAGTCCAG
AACCCTI'GCT
GCGAATI'GGA
AAAGCCAATT
TGAGTATTGA
GGGTTIATC
TACCGAGTAT
TCGTAAAAAA
CCGCAATCA.A
GCGGAITTA
CTCTCAAAAC
AAAAACTTAT
GCCCTI'AAAG
TCTCCAA
120 180 240 300 360 420 480 537 INFORMATION FOR SEQ ID NO:l0ll: SEQUENCE CHARACTERISTICS: LENGTH: 1356 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOT HET ICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAM~E/KEY: misc_feature LOCATION .1356 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1011
TTTAAAAGGT
GGGGTGAAAC
AAAAAACATT
ATGGTAGAAA
GGGCCTATGC
AT1'ATGATAA
TATGGTTATA
GAATTACTGC
GATGTGATAG
CAAAAAITAA
GTITITAGCG
ATTAATGAGC
CGTGCGGATA
TTAGGGAATA
AAAAACGCCC
GAATACCTGA
AGCGAATGCA
TTIAGCGATT
GTGTTAGAAA
AGCCTAGTGA
GCTCTITAA
GAAAACAAAT
CAAGAATTAA
ATTFI'ATAAC
TCACCCCCAT
CTCAAACGAA
ACGCTTTAGT
CTACCCCTGC
GCGCGAGCCA
AACTCAAAGA
ATTCTAGCTA
GGCGCTATAT
GGATCGTGCT
AGC'ITGGGGC
AATGCGGGGC
TAGGCT1'TGC
TCGTGCATGG
TTTCTTCTCA
AATCCCAAGA
TGCGATTGAA
ACGCTAAAAC
GCAAGCTI'GT
ATTTGAATAT
AAGAATTAGA
TACGAATCCT
AAGAXITTT
GATGAAAATI'
GTTT~GTGATG
TAAAATTCTA
GAGCGCTCTC
GATCGC TT
CAACCCFI'TT
AGAAGAAGAA
TAAAGTGGGC
CGCGCATTTG
AGATACCOCT
TGATGTTTTA
TTTACACCCT
1117 GATGC
GGATAAGCTT
AGCGGTTGTC
TTrAGAATTG
TAAAGCCAAT
GGGCGATGGT
AAGCTCTTT
CCAAAAAAAG
CCAACTAGAG
TTIAGAAGCT
TGAAGGGCAG
TTTGGGACTG
CGTFI'AGGCA
ATCGGTAAAG
ACTTCCATAG
ITAACCGAAG
GAAGACAATG
AGAGCGAITG
GAGAGCGTCG
AAGCACTCTT
AATGGCGCGG
GTGATCAATG
AACCAATIGA
GATGCCGATA
TTAGGGGTGT
GCTACGAGCA
AAGCATTGCG
TTTGGGGGCG
TGGTGTGCG
GCGTITAAACC
CCCCCITI'AG
A TCCGCCAT'r
AAAGACGAAA
TI'GTGC
ATGGCGTGAG
TTGCTGCCGG
ACACCAGAAA
GCTATAATGT
ACATGCGCTG
GCATCAAGTT
AAGAAATC'rr
GTAGCGCTAA
TCCCCAAACA
CTTATAAGGT
ATGAGCCTAA
GCCAGGAAGT
GGCTAGTGGT
TAGGGGTT1'A TGAGCAA'rrr
CGATTGGGGA
AGCAAAGCGG
CTrI'GCAAGT
CCTTTGAACT
AAAGCCTGAA
TGATCCGr1'A
AACTITTAGA
GGGTAAAGCA
ATTGTATTr
GAGCGGCTAT
GATCCAAATA
TGATGCGGGC
TTTCAATTCC
TCATGATGAA
AAGGATAGAC
TTTGAATTTA
GGCTCCGGTC
TGGGTGTAAC
GAAAAA1ATAC
GGCGGATAAT
TCAAAAATCT
AGCCCTTAAA
TAAGTI'GTG
GCATATCArr GAGCGCGrI'A
ATACCCCCAA
AGGTTATAGC
TAGCGGCACT
ATCCAAAATG
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1356 4* 9*
S
INFORMATION FOR SEQ ID NO:1012: SEQUENCE CHARACTERISTICS: LENGTH: 333 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 333 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1012
S
a
AATCATCAGC
GCAAGCGAGT
TATAAACATT
TATCAACAGC
TGTAAGATTT
CAAGCCAAC
GAATACGAAG
TAAAAGTGCG
CTGTTIGCTT
GTI'ATAGAGC
TTATTCCCAT
TAAAAAGAGT
CCGCCAACAA
ATCTTGCAAA
AAAGCCTT
GTITGCTCTA
AATTGAT1Tr
CTCTAATGCC
T1'AGAAAGC CAGXTrrG
TTTAGGTT
ACGCTCTTTT
AAAATCGTTT
TAT
CGTI'TGATCC
ATAAGGGTTr
GTTFI'CTCAA
CTGTAAGTT
TI'ATCCCTAT
CTTTAGAAGA
AAAGCCCTAT
AATI'CATGCT
TITTTAACGCT
TCTAAAACAC
INFORMATION FOR SEQ ID NO:l013: SEQUENCE CHARACTERISTICS: LENGTH: 600 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 600 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1013
S
S. S S
S
*5 S *5 S S
S
AAGCGCATGA
ATI'GAACGCT
AAGAGCGCTA
ATTGAAAAAC
AGCCCTAATG
ATGGGGGCGA
AGTAATTT
AGGGATTTTT
CTTATCGCCA
ATACCAATCA
AAGA.ATCTTT
CTTTAGGACG
ACATTGAATT
TGGGTTATAG
TTAAATTAGC
TGCT1'AGCCC
TAAACGCTTG
ACATTCAAGG
TAGGCACAAG
TTATACCGAT
TI'ACATAGAG
TAAAAGTT
TAACGAAAAT
CCCTAAAAAA
GTTGGCGGTT,
TAGCCTTTrA
CTIACAGCT'
GITTAAAGCC
TGCTGCC'1TA
CAGTGGTCTT
GGAATGACT
GTGAAAAAAA
GAAACCAAT
ACTCTAGCAG
ATTITCACGC
CCTGAAAGCT
ATAGGCGCGC
TI'ATGGCACA
ATITCAGCCT
ATGGGCATTA
GCACGGCGTG
TAGAAGTGAG
TAGACGAAAT
AAGAAAAAAA
TTTTTGTGGT
TGCTTACGAT
TCXFI'GTCAT
GACAACCCAA
GTGGCAATTG
TTATTITGAA
TTCTAGCGGG
CCT ITAAAT
TTITAAACTC
AGAA~TTTI'T
GTATCI1'TC!T
TAACCATCAT
GCA TI'GGGG
CATGAGCAGC
TATTTGGTI'
AGCGTGTGCG
120 180 240 300 360 420 480 540 600 INFORMATION FOR SEQ ID NO:1014: SEQUENCE CHARACTERISTICS: LENGTH: 723 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .723 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1014
AAAGAGTCTC
AGTATrrITI' TGTT1GGTTAG
ACCAACACCA
GGAGTCGCCC
ATGGCGGTGA
AGCACCAACA
TAATGCCTAT
TAGGCATGAT
TGGTGGCGAG
CTAGCAAGTIT
CAAGCCTTAT
GCGCGTIGFI'
CAAGCGATCC
TAACCCTCTC
GAGTATrTI'
TCITAATTT
TGGTATTGAA
TACTrACITT
TGTGATTI
CTATI'CTITC
TATCTTI'TCC
TACGCTI'CCA
GATGGGCITG
ITTGACTCTT
TATGTGGGGT
GGAGCGATAC
ATCGGTATCC
CCAATCTTTT
GTTACCAAT
ATGGGCGTGT
TAGCTGATGT
ATAACTrGG GAT'rAGCGCG CCAT1'CCTGC
TACCGCTAGC
TGTCATGGCG
CGCAAGGCTT
GGTCGCTrr
GCGTATAGGC
AT'CA.ATATC
GGCGGCGGTA
120 180 240 300 360 420 T1'GGTGGTGC
AAGTTIATTTI'
CCTAAFTI'A
TCGTTAGTGT
TATGGCATCA
GCA
TTTGCGTGTT
TAGGCTITAT
AAAAAGTCAA
TTGTGCGCCC
TTCGGTGGAT
ATI'AGATAAT
TGTCITATTA
GTGGAATCTC
TTTAGAGGCT
CTITTTTAATG,
AAATACCT
GGGGTGcTTA AAGCTTTTlCA
TTGAGCGTGT
GTAAAAATTA
TCTTAGAAGG
TGGTGAGCAA
TCI'TAGTGT
TTATGGGGTT
CTTTTAATAA
CAATACCGAA
TATCCGCTAC
GATCTTITA
GTATI'TGATC
AAATAAAAGC
INFORMATION FOR SEQ ID NO:1015: SEQUENCE CHARACTERISTICS: LENGTH: 753 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .753 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1015 9 9. 4.
9* 9 9* .99* 4
TATI'TGCCCCG
TTGAGCTTGA
TCTAAAGATC
TACGGGTIAG
TATCAAAGCT
ATAGATI'GTA
AAAATCATTC
AAAAAAGAGT
CCTAACGAAT
TTTGAAGCGT
GCTTAFTI'G
AAAGATATAG
TTAGAGATTG
CAAGCGAAAA
AAATAGACAG
CCTTTGCGTIT
AATTGATTTI
TTGATTTAGA
ACCTCTCTAT
AAAAAGTCAA
TGCTTTTTAG
CAAGCGGGT'
TCAACGCGAT
GTTTGCATGC
AAATCCAAAA
GGGATATTAA
CGCCCCCT'G
CCTGTTTT71CT
AAGGCGTG
GAAAGCGGAT
GGTTTTAGAA
TATAAGAAGT
AGCCTTAAAA
CGCITTTCAAA
TI'CTACGAGT
CAAAACAAGC
GCCTAGAA
AAATCGTAAA.
AGAAA'FTGCG
CCCTCTAGTG
CTTTITAGCG
AGTTTTGGGC
TTAAAAAACC
AAGTIT1'TAC
GTGTTAAACA
CGCTTITIAG
CGATTAGCTA
CTTTTCAAAG
ACTTITGAGA
GAATATrFTA
AATITCTTGT
AT
TTTITAGITC
TGGGTAAAAT
TATTGAAAAT
TCTTTGAAAA
TGGAGCGCT'
CCAACGAGCG
ACAATCCTAA
ATATCAATAA
AATTACAAGA
GITI'GGATAG
AAAGCGTGCT
GGGGCGTGTA
AATCGTGGCT
CCCTAGCGGA
CATCGCGCAT
AGTGGGCGI'
TCATAATTTA
AGACATTGT'
GAACGCTCAA
AGACAGAAAC
GCATGCCCTT
CAAAATAGAG
AGTCATGGAT
TCAAAGTTTC
120 180 240 300 360 420 480 540 600 660 720 753 INFORMATION FOR SEQ ID NO:1016: SEQUENCE CHARACTERISTICS: LENGTH: 1782 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/ KEY misc_feature LOCATION 1. 1782 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1016
GTGGTCTTT.A
T1'ATACTFIAG
CCTAACGCTA
AACCCTTTG
ATGGTGCAAA
GTGGCTAAGG,
AACGCTCCCA
TCGCCCCTTT
CATGTTAAAT
TTGCAGATCT
ATTCCTGTI'
AAATTTIAAG
GCGAAGAACC
GAAAAGGCGG
CGCTTAAAGG
GCTTAGACGA
ATAACAGCTA
TTTAGCGAG
ATAGGCAGTA
TCATT'TICAA
1T1CCAAAAA
CTAGTGGCCC
TACCAAAGAA ACCCTAACTA =FTGATCAAA TCAAAT=IGA AGCGGGGCGT ATGATTGGCG 00
GGGAAAGCTA
GGCATGCAAG
GAAGCCT1'AT
TACAAGCGCA
CCTGAAGAAA
GAGCCTTATA
AA'ILrAAAAT
TI'GGTGGATA
GAAAGACTGG
CAAAGAGTGG
GTAGGAGTGA
TTGAGCGCGA
GATITGATTG
GCGATGGATA
TACAGGATCG
TCGCCGTATT
TGGATAATAA
GGTT'TCTr
TI'TATGCGTT
CCACTAGT TT
AAGCCCTGCT
TCGTGCCTAG,
ACGCCCAAAA
AGAATAACAA
CCCTAGCT?
A'FTrAAGCCA
TTGGCCAATC
AAGCCAAAGG
AAAGAATCAT
GGGTGTTGI'
CAGCGTATAA
TATGGTGGAT
TFIATGGTTA
CAAATATAAA
TGTITTGAGA
CACTAAAGCC
ACCITTTGCA
TGTGATTFFI'
CGATGTGAAG
TTACCAAGAT
AACCACTGAA
AGCG'I'ITCAA
TTATGTGATC
TIGGGCGAAA
GTAF1'ACAAA
CCTTGAAAGC
AAAAATCACT
CAACACGCGC
TGATI=GAA
TTICAGTAAC
AGCCCCTTAT
AACCGATGGG
GCTITTAGAG
GCCTI'TCAGT
TGCTAAAAAC
GTATGTCAAT
GTC=rCCCA
CACAAGGAAT
TCACGCTAAA
GCGGGGGTT
TTACATTGGC
AAAAAAAGAA
GGGGTG'I7TT
GACAATTTCA
AATGACGCTA
GAAGGCTI'GG
GAATACCCCT
ACCCTAGATA
TTTAGCTTTG
GTITAAAAAGG
XAATAAAGAAT
AAGGATTAT
GCTTCTTTTG
AAT1'GCCTA
GATGAAACCG
ACGGCTAAGG
AAATACCTCA
CGAGAAATTT
TGGGCGAATA
TCTATCTATG
GAAAAGAGTT
CCTGATGTT
AGCGCGGGCT
TTCACTITGC
TI'AAGGGTGT
CGGATCAAAA
GGTAATGAGC
TATGCGCGAA
GATI'ATAAGG
TACGCGATAC
ATGCCTGAAA
AGGGGTCCTA
GTI'CCTTAG
CGCATTTTGA
TAGGGAC'IT
ATCTCATrI'A
TAATCGCTAA
AAAGAGCGAG
ATACGATAAT
CGGTI'ATCTT
TGCCCCTCAT
TI'GAAAAAAA
ATGTGGGCAA
GCAGAAAGGG
TCGCCTTAC!A
TTTGGGCTAG
TAGCCCACAA
TCAAGGATA.A
AAAATTTGTr
CGTCCCCTCC
TGGATGAAAG
TAGGCTATAA
'FITCCTACAA
TI'IAAACAG
TAGGGATI'GA
GCTATGATITT
AGCGCITTTA
TCTCTAGTAA
AGCAATTGGC
CGCAI"ITrA
TCAGCCCTAG
AA
GGCTACGCAT
ATACGCTAAC
TGATAGCCTr
TGACACTTTA
AGACGCCGAA
ATTCAGCAAT
GAAATTAGGA
AGACAAGCAC
TTAGGGCAG
CCCTTTACTC
GAAAATCACC
GCAXITCAAT
GGCTTTTTTA
GGGCTATGTG
AATGCCAAGC
AAGGGTGCGT
TTTTTCGCAA
TCTCCCAAGC
GGTTFTTAAA
TTTGAGGGAA
AAACATGCGT
CCCGGCATT
AATGAAAATC
TGACATGAT
TITTGGCTCT
AGCGGTAGAT
CGCCATTCAA
TTTGCCTAAT
CTATGGATT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1782 INFORMATION FOR SEQ ID NO:1017: SEQUENCE CHARACTERISTICS: LENGTH: 603 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAIAE/KEY: misc-feature LOCATION .603 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1017
TCTGTGATTG
AAACTCGTT
GCCATTAGCC
AGTATTGC
TTGGGTGTT
GTCGTTAI-IT
GTGTCTATAT
TAGAATCCAA
CCAAACATCA
AATCTGATIG
A TTAAGCCA
TAGAAGATGA
CAITCTI'A
TGAAAAATT
AGATTTGAA
GTATCAT
TIATCT=A
TGTAACGCTA
AAAGAAAGTC AAAGGCGTI' AAAGGCCGTI' GCGTTITCCA AAAFI'ACTI'C AAGAGCTA TATGTTGGCG CTGGTFITGAC TGGAAAGAAT GCGTCAAAT1' GAGTCTCATI' TCATGCAAGC
GGATACTGAA
AATCTTTGAC
TAACGCTCAA
TITGCCTGAA
AGATCAACCO
CTIAGAAGAT
TGTI'TGAAAA GCCCTrTI'GA TTITGTGAGA CTCTATGCCT ACAAAATI'CC ATGTTTTGCC CAAAGAATrT GTA TTTCCTC AATAACCCTA T'FrTAGAAAA A TITAAAAAA TTT TGATG TCTACCCATA AAGTCATCCA CCTATATTCT CAAAAAAATA
GCA
GT1'ATI'GGTA
CCTTTGATCA
=TCTAGATTr
CAAAAAAGCT
TTACUAUA
TTC'TTFTAAG
TTTAAATCT1'
ATTACGCAAC
INFORMATION FOR SEQ ID NO:1018: SEQUENCE CHARACTERISTICS: LENGTH: 1620 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genornic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1620 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1018 9e 9 9* 9.
9 9 9 .9 .9 9 *9*9 9* 9 9 9
'FITAGTGAGC
TGTGGATTTG
AATAATAATA
GCTCTTITA
AAACAGGCTT
GTGAAAGAAA
GAAATCTATG
CCT'FTCACGC
AATGA'TIGA
CTAGACGCTI'
CAITACGCCC
CATGGTI'ATG
CTAGAAAGGA
CAAAAAATCG
CTAAGCCGTA
TTTAGACA
ATGCCAAGCT
GAGCCAAAGC
GCGGGCGGGA
CTCATTCCTA
GCCATTATTA
AAGCAATFI'A
CTAGGGACTG
AAGCAAAACA
GAAAACAAGG
TACACTTI'
GGCGTGCCGC
GGGACTII'GA
GATTCTTGTC
ATACCCTACC
AAACCITTTI'
TCACTrATTI'
GCGATCTTAT
AGATTGTCAA
ATIT'AAAA1T
TCCTTITATT
TGAATGAALAG
ACTCTAAAGA
AATGCCTT
GTGCTAATGG
CGCAAATTGG
GCTTGCAA.AA
GCTI'GCAAGC
TTACGCAAAA
CCTTAAATrI'
AAACCATGCT
TGAAAATCAA
ATGACCCCCA
GCGCTC TT
ACGCTGATGA
ACCAAATCGT
AAGTGGAATT
TAAAAGGGGT
CTTTTGAT
GCTTIT1'AGG CAAAAAACAA AGACGCITCA AAAAGATCCC CAAACCCCTA GAAGAAAGCC CGCAAAAGAA AGAGGI'CTA ACCCCTATGA AAGATGTTCT TTAATCCAAC CTAATGATG TAGATTI'AAA AGAGTTTATC TTGCTITAGA AAACGATCTC
AAATGAAGTG
TGTI'GTCAA.A
ACGATTGCGC
TCATGAACGC
GGATGATGAA
CTTGAACCC
GCTTGCCCCT
ATrAAAAAGC 7rATI'TCTAT
TAATGAAATA
ACACCT1'A
ACGGCTTAAT
AAAAATGATI'
GAAGTIGAA
CTI'AAAATCG
CGCCCATCAT
AAACAGCGCG
ATCCAAAGAA
AGCGAGCAGT
TATCACCACG
ACTGGCCGCT
GATGCGATCG
CTCACCAAAT
TACATTGTCG
CTI'AACGCCA
GGGCAAATCA
CTIAAAAAAG
TATT'TAGTGG
GGGTTTTCTA
CTFFI'GCCTG
GATTGCTGTA
TTITTAAAAT
TCGCTAAAG
TI'AGAAAACT
AAATCCATGC
CITI'TA.AGCG
TCTACTATCC
AACAATATCT
AACATGCTCT
TTGTATAAAA
CACCACAAAC
CTF1'ATGACG
GTITGCCTGC
TAGGGACGCT
TITTACAAAA
TTA1TI'ACC
AACAAGGGGC
AGAGCACTAA
ATACGCA.AAG
GCGCGATCAA
AAAGCGCGCA
TCGTI'GAAAT
TCCTI'TTTAA
CCTACAATT
TITCGCACCC
TCGCTGTTAC
CAGCTTTT
CCTATITI'AG
CTACTITI'GC
TAGGCGTTGA
CCCTGTTAGA
GCCTGAGCGT
AGGAAAAAGA,
TTGAAACCGC
TGGCGAAGAT
CCCCAAAAGC
CCATITAGAT
CGCCTFXTAAA
CCCTTT
GAACGCTACC
AATCATI'CAC
CCACC'ITAAG
AGGCGTTGTG
AAAAATCGCC
GTGCCAAACT
AGAATTTGAT
AGAATITGTC
CATTITAAAA
CGGCGTGAAT
GAGCAAGCAT
AGAAATCCAC
AGGCAGAATG
TGAAATI'GAG
AAAATl-GCTr
GTTAATGGCA.
ACGGCCCACT
TIGCGCTAT
AAGGAAAAAT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 TATTGGCAAA AGCTATGCGT TGAAAAGCGA AAGCCTTCTA INFORMATION FOR SEQ ID NO:1019: SEQUENCE CHARACTERISTICS: LENGTH: 1365 base pairs TYPE: nucleic acid sTRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .136S (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1019 9**9 9 9.9.
@9 9 9 .99.
*9 99 9 *99.
9* 99 9 9 .99.
99 99 9 *.99 99 99 9
AAGCTTACCG
TGCAAGATCC
AAAGCGCAAG
TTGAAAGCTT
GATGTCATCA
GAATTAGAAA
CGCGTTTA
ATTTGCCCCG
CGAGAGAGCG
T'11T1CCAACC
GACCACGATT
AGAGTGATCT
GAAAAAAAAG
ITI'GAATTGA
AATGCGAGTT
AAITI'ATTGA
ATTCTCAT1'G AGGA TI'ATG
AAATACTCTC
GACAGGTGA
AAAGCCCATI'
TTITTAGAGC
GGCTITGGAG
AGAAAATI'AT
ATTTCATCGG
GGGCTAAGAT
TAGGCGTAGA
TCCATICAGC
TCCCTATTTT
GCGTGTGTGG
CTTTTGGAGC
CGGATATGAG
CTTITTTGCGC
TAGAACGCFI'
ATAAAGAAGA
ACATI'TATAA
AAAATTTGGG
TGGCGATTTT
A'IITIAAAGG
ATGAI'ACGC
CCAATTTATT
GCTI'AATGGA
TCATITIACC
TI'AAGCATTA
TGTTAGTCAA.
CGGGGGATAT
GCITGAAACC
TATAGGGGGG
CAGCGGATCT
AATTAATATC
CAITATCAAA
GTCTCGTAAA
GGCTCATGGA
GATTATTGGG
GATTGTGCCT
TF1'CITCGCT
TCCTIFITI'A
TATCCAATAC
GGCTITITTG
AAGCGCTTTA
CATI'AAAAAA
CCACCACCCT
CCAAAAGTI'
ATTGGCATTT
GATATrGCCA
CCGCATGATC
GAAGACAATA
GACGCTTTGT
AAGAGCAGTA
GCGCATTCTA
GAAGCCGATG
AACACGGAGC
TATAAATATT
AAAAACTATT
A'T1'AAAAG
GTGTGGGGGT
GATGAATTAA
TACTCAAAAA
CAGGC'FrAGC
TAAGCCCTAG
CAAAAGCGAT
CCGAAATACA
ATCTATCCT
TCACGGCCAT
AAGAGITTGA
AAAGCGATTC
CAGAACATTT
TTTTAGACCA
CTAAAGACGC
ACGGAGAGCC
TAGGCGAACA
ATITAGAAGA
CCTGCAAGAT
CAAATACCT'
CGTTAAGTAT
CAACCATCAA
AAGGGCTAAG
TAAAGACAAG
GTITGAGCGCG
TTCCAATGTG
AAG'T1'ITTA
GGAGCATI'AT
TGCTCAAAAA
CATTGFFTA
TI'ACACTTCG
TAACGCCACG
AATI'AGAAAT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1365 CGCTr1'GATA TFITGCAAAA AAACGATCTC ACTGAAATrG GCACCACTIT AAAAAGCGCT GAATACGCAA GAAAAUAATI'A TAGTGATCTG GCAAGCGCAC CAATTAGAA GAATI'TAAAA AATGTITT AGAGCA'rTGC CGTTTATAGC GCGAGTGAAG TTAAAAGAGA CATI'GMTTG TAACCCCACC TTTATAGACA GGGTGCGTAA AAAGGGGGAT TGATAATGTG GTAGAAACGA TTGAAAAAGG CTITGTGATA TACCTATCAG TTGAGAGGCG AAATG 9.
999 9 INFORMATION FOR SEQ ID, NO:1020: SEQUENCE CHARACTERISTICS: LENGTH: 201 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .201 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1020 GCGGTAACCG CCATFFFIAGG GTGGGACGAA GAGGGCA AGC TCAAGTTTGG GAAiNURUL.
CACAAATAT TAGAA.ACGAG CAACGTGAAT GCCGGGAACG CCCTAACCAA TCTCATTTA ATGCAAAGAG GCTATTCTAT GAACGCTAGA GCCTTTGGCG CGGGCGATGA CATCATCAAA GAAGCCATA GCTTGAAAAA A INFORMATION FOR SEQ ID NO:1021: SEQUENCE CHARACTERISTICS: LENGTH: 558 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .558 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1.O2l AAGCTACATC GTGGATCCCA GGC TITGATT CAGCCACGCA AATAAACTCA CCTATTC TrT CAAGACTCTA AACTCITAAA ATGCGCATTG AAGAAAATGG GTCGCTCGCA TCGGTATT AACCTCTATG AAATGCAAGA CGCCAFFI=TA GGGTGGGACG TTT AGWACG AGCAACGTGA AGGCTATTCT ATGAACGC
AAAACAAAAC
CAAAATGAAA
GGATAAGAGC
AACGAGTCAA
CGTGATT1'CT
AGCTTTCACT
AGGCACCATT
AAGAGGGCAA
ATGCCGGGAA
CCTATCAATG ATCCTACTTG TCCGCCCCCA TGACTTTGGA GAAAACATGA TrCTAACCAA GAACGCAACC CTAGGGGCAT CTAGCCTFITA GTAACGGGGT AA~CGATCAAG CAAGGAA AATGGCGAAA ACAGACCCCT GCTCAAGTIT GGGAAAATCA CGCCCTAACC AATCTCATTT
GGAAATTGTC
TTTTAAGGGC
ATTG'PTCTAC
TTTTAGAGAC
GGTAGAGCCG
AATCGGCGGT
AAGCGGTAAC
GGCACAAATA
TAATGCAAAG
0* INFORMATION FOR SEQ ID NO:1022: SEQUENCE CHARACTERISTICS: LENGTH: 516 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION l...516 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1022 TGGATGTTTG TAGITAAAAT GGTGTIAGGG ITITTGATCC TITTAAGCCC TF1'GTGCGCT
ACTGGATTGG
GTGGGGATTT
CTTGAAATCT
AAGAAAAAAC
GATGCGAATA
GTGGAAAATT
AGAGAGTTGG
GCGCAAGATT
ATATTI'CACA
TGTGGTATIT
CCA.AACGCT
TCCTIAAAGA
AAGAAGCCTA
TGATCAAAAA
TTGAAAGCGT
GCGTGAATAT
AACAGACATI'
ITI'GGCTAA.A
AGAAGAGATT
ATTAGAGCAA
CACGATCACG
TTCTAAGGCG
TITTAAAGAT
TTTGAAACAA
ATAGAGCGTT
AGATTGCGI1T
CAAGCCCAAC
GCCAAAGAAA
CAAAAATACG
TTGATGGATT
CTAAGAGAGA
AGGCTI
CTTTAAATTT
CATTTTITGCA
TTAAAGTGAG
AAGCTGAATT
AATTACAAAC
TAGAAGTTAA
GTAAAAAAGT
T1'CCAAAAGC
TAAAGAACAT
GATTATrI'CT
CAAAATGGAT
AAAGATCAAA
GTCTTTCAAT
120 180 240 300 360 420 480 516 INFORMATION FOR SEQ ID NO:1023: SEQUENCE CHARACTERISTICS: LENGTH: 744 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .744 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1023 a a a. a a a 0*@a a a a. a a.
a a.
a a a
ATGCAAAAAA
GTITGGTTTAG
CCCCCTATCC
ATGGGAAAAA
GAGGAATGGC
AAGGCTTCTA
AGAATCCATG
AAAGCCCATG
AAAAGCGAGA
GGGTATI'ACT
CTCAAAACTT
CCTI'ATAAAA
AATAAGCCTG
GTATATI'CAA
ACGATAAAAA
AGTTAAGGCT
GCACGCAGTA
TAGGAGTCGC
TTGA.AAACAG
ATTTATATGA
AGCATGAAAT
ATAAAAAGGG
TGCAAATTGG
TCCCTCACCA
CCAAAGAAGA
CGTTGGTAGA
AATAACTCTG
AGCAGCTCCT
CGATCAAGCC
TGAGTTCCCT
CCATGAAGAA
CCCGAIT1'AT
TTTTTATATA
GGCCCTCAAC
CTTAACAAAA
GGCTTTTA
AATGGAGGAA
AGCCCTAAAA
GAAG
TTGTTGGTTT
AAAAGCGT'C
TATGAAGACC
AA.AATTAAAG
TGTGTGGCGT
AAGAATTGCT
GAGGGCAAAA
AAATCCCAAC
CCTAGCTTGA
AATT1CGCCCA
AAAGACTCCC
CAGCTTGAAA
TCCTCTTITTT
AAAATACCCC
F1ATCAAAAT
AAATCCTAGA
TAGTCATGTT
ATGAAGCTTA
AAGTGAAAAG
CCTTAAAAAA
AAGACGCAAA
GTAAGGATTT
TCACGCATTA
ATGCGGCTAA
AAGGAATGCT
TAAAAATTTA
GTI'AGACAAT
ACAPLAGCGAA
AATAAGCCCT
TGTGAAACAA
AAAAATCAAG
GGAACCGCCT
GATCCCTAAA
TITGCAAACG
TTTGAT'GGC
AAGCTITAAA
120 180 240 300 360 420 480 540 600 660 720 744 INFORMATION FOR SEQ ID NO:1024: SEQUENCE CHARACTERISTICS: LENGTH: 681 base pairs TYPE: nucl-eic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc feature LOCATION .681 (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1024
AGTGGATGCT
CAAA~AAATTG
TI'AGGTTATT
AAAATCACTC
AATATCACTA
TATGTTGTCT
AAACCATTAG
AAAAATGGCG
GGCTACACTT
GCCGTTACCA
GAATACATCA
AAATTAGAAG
ATTTTGAATC
GCGTGATCGT
ATCTTAAAAA
TCATTGTAGA
CCTTGATGAA
TGGCGA'FTGA
GCATCACGCT
ATAAGATTCC
TCGCCTCTGA
GTCGGGTAAC
CCAAACCTI'A
GAGACCAATC
CAACTCTGAT
GGATTAT'TG
CACTAGAGGC
TGTGGGGGCG
CGAGTCAGAA
TGACAGCAGC
CTI'AGAGGCC
GGACGCTATI'
AGTGCGTAAA
TAAAACGGAC
TAGCGGTGAA
GTGTATGTGG
ATCGGTCAAG
ATTGCTGGCG
ATGATGGAAA
AACACGAAAA
ACGGACAGAG
ACTAACGGCT
TTAGTGGATA
TACAATAAAT
AGAATGCGCG
TA'TIAACCA
TI'ATCATIGG
AAGAAGTGGT
CTACGGTGAG
TGGCAAAGAG
GCAAAAATTC
CGATTATCCG
TAGAGGGCTT
TITGAGATGCC
TCAAAAACCT
GCGTTGAATC
CCGTAGTGAA
CTTGGCCGAT
CATCAAGTCT
GGGCGATGGG
CATI'AAAGTC
TCCTAGCGAT
CAAATGTI'A
AGAAATGCTC
TAAAATGGAT
GCCCTTGATC
CGGCATGACT
GCGCAGCATT
120 180 240 300 360 420 480 540 600 660 681 0O S 09*P
S
S
S.
SS**
S. Sq S S S S S. Se 55 INFORMATION FOR SEQ ID NO: 1025: SEQUENCE CHARACTERISTICS: LENGTH: 828 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .828 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1025
S
*5@e
SS
S
ATGACCCTT
GGGGGGTI'AG
CACACGCATG
GGAAAGCGTT
CGCTCTTI'T
CAA.AAAGCCC
GGGAGCGGAT
AGCGATATTT
AAAGAGCGTG
Cfl'GTCTCTA
GAACCGCACG
IITAGCCG
AAGAGCTTGA
AGCGGCTrI'G
CACAAGCCCT
AGTCTGAAAT
AGCATTI'GGA
TGAATGACTG
TCGTGAATGA
TTAATATTAT
GCGTGTCCGT
CACCAAAAGC
TTTTTTrAAA
ACCCGCCCTA
AAGCCCTT
CTAAATTAAA
AAGAATGCT
ATAGAGGGT
AAATAAAGCC
TI'TATTAGGC
AT1'AAGCCAC
CCCCATAGAG
GCATGTITI'A
TI'CTCAATAC
GAGTFTGGCT
?I'TAGAAGTG
ACAAACGCGC
TATCGCTAGA
TGGGGGGGTT
AATCCCTIT
GGAGTTF1'GC
AAAAAAGAAT
TTTGTCTTGC
GAAGAAGAAA
TATII'ATTAG
ATCCCACGGC
CATI'TAAAAG
TTAGAAAACC
GCGTTAAAAA
CTTTGGGATC
AATTATCCT
AAAGGCGATG
TTGGTTTGTG,
GGTI'ATGATG
TATCGCCAAA
AAAAAGAAAG
CACGCTTTIT
GAAGCTGTGA
CTGAAACCGA
AAPLTAGGCGA
CTAATCTCTC
ATATTGAACG
ATATGCCAAC
TGGAAAAATC
AAAkTCTTAAA
AAATGGGGTA
CAGAGTTI'A
TITTAAGA
AGGCTTTAGG
GGTITFIITG
TGAATIGGTA
TrI'ATGGG GAT1'ITAGTC
AATCGGCATA
TATTTATGCG
CTTITGTCTA
GATAGAAATG
CTCTCAAA
AGAAATCGTT
TGACCAGTTA
CAAGGATTTG
120 180 240 300 360 420 480 540 600 660 720 780 828 TGTGGGCGTI' TTAAAAAG'T INFORMATION FOR SEQ ID NO:1026: SEQUENCE CHARACTERISTICS: LENGTH: 564 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .564 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1026
AAAGCCGTGT
AAGCGTTTT
'FrGTTITI'CT
ACCGCTGATG
ITAAAAATCT
AGAGTCAAGT
AAAACCCCTT
AACCGCTI'AG
CCCCTTTATA
GCCATGTGGC
TGTICAACCC ACTAC TAATCGT"]A TACCC TITATGCGAA AAAT; CGATCGCTAA AAGCC TAGAAGAACG ATTCI TTTCTAATAT CGGG( AITTTGCGCT TAAA2 GGGTTTCTAA AATC~ AAATGATAGG CTAT( TTI'ATAAAAT CCCA CAACA AAAAGGTCCG ITCT ACCTTGCTTT
~ACTT
.TTTTA
LAAAAC
;TGTrr
AAAG
k.TTATT
TGTTT
TTGGAAAACA
GAATTAAATA
ACCCCCTTTG
GTGGCCTCTI'
GGCTTTTACC
GCAGAAGAAG
TTGGGCGCGA
TCATGCCCCA
TAGTGGGGGT
CCCAAATACG
ATGCCTCTTC
TTI-IGTTGGA
TTAAAAATGA
TCACAGACAG
AAATTCAAJ'A
GTFI'GTFIGT
TTCTTTAAAA
TTTGTTAGCG
CATGCAATAC
TTTAGAGCCT
CGCAGACAAC
CGCCTTAATC
CGCCCCAACT
AATCTTTATC
CGCGCTAATA
120 180 240 300 360 420 480 540 564 9 *9
S
Ct
S
S..
INFORMATION FOR SEQ ID NO:1027: SEQUENCE CHARACTERISTICS: LENGTH: 1224 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1224 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1027
AATATGCTTG
ACTCCTI'ACA
AAGCCTGTTT
ATGCAATTAT
TITGGTTTGA
TACTTGGTGT
TACTATACTA
TTTTAAGG
TACACTCTCA
GTGTTTGTT
CAATTCACCC
GTGGGTTTTA
AACGCGTATT
ATATATGGAT
TTGTAGGCGA
TACTCCCACA
CCATITATTC
CGCATTTAGA
TGCCT1'GTT
CCATGCA'TIT
ATITITTCAA
TAATGATCAT
TCATGXTT
CCGAATAA
AATCTCAAGG
TTGGAGGCTT
AGATATGATA
TATTTTGCAA
AAAGGATrAT TCAAAT1ITTA
AGATCTCACG
GTTTTTTAGCG
GGATAAGGAA
AGGATI'ATI'G
TGAACATGTG
GGCTAATCT
TAGGGATTTA
CATCTTTGTG
GGGTAAAAAC
ATCTGTATFIT
TI'GAAATTTA
GAAGAAGCGG
GATGGGGTGA
CA'TTI'TAA
ATTCAAAGCG
TTTGGCT1'
CTCACITTAG
GAGCATTGGG
TI'ACCCTA
GAAAGTCAAA
ATGGACGCTA
AAGCGGGTIGG
TTI'ATFI'GCT
TCCGTCAAAA
GAAAT1'ATGC
TCI'TGCTGG
ACCTTCCTGA
TITTAGCTIT
CTAAGGTGAG
GCGTGGGGTI'
AGATCAGCTC
AAATCGCCCA
T1'GAGAGCAT
GCAAGAGGGA
TGT1'GTTTGA
CTTITTACG
ACTCTGCGAG
TATTAGGAAA
TTGGGTCTT
AACGCTAGGT
ACCCATTAGC
=rTATCGT1'G
GTTGTTGAT
GI'TrTTGTC
GCTTTCAAC
GATGGATAAG
TGGGCGTITG
CACTTI'GATC
120 180 240 300 360 420 480 540 600 660 720 780
TCTAAAGTTG
AATAAGGATT
TTGATCGCTC
AGTTTGATCA
ATTGGG~iTiT
TCTAAAGAGA
TATTCGCACC
AAAGCTTTGG
GGACAGAAGG GCTFTTAGCC TGTTGAAAAA ITTAGGGATT A TTI'GCCGCC GTrGGTTT CGA'ITCTACT CTTGTTI'TTG TI'AGCCGCAA GAACGAATAC CTTTAGCCAA AGCGTTAGTG CITTITATGT TTI'CT1'GCAT ATTATGAAAT TGAA
AITTTAGGGC
ATGGGAGGCT
GAAGGCTTTA
CCGGTGTTTr
AATGCGGACA
TCcATTGTGA
TI'CACGCACC
ATGAGTI'AGG
TGCTCGCTCT
ATGTCTCGCA
CCTTTTACGC
AGTTTGGGGC
ATGAAAATAA
CGCCGCTATT
GCATTIrAAA
TGTITTTGCT
AACGCCAGCG
CATGCCTI'TG
GAGTFI'AAGC
AGCGTI'CCCC
AGAACGCCTA
840 900 960 1020 1080 1140 1200 1224 INFORMATION FOR SEQ ID NO:1028: SEQUENCE CHARACTERISTICS: LENGTH: 432 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAIE/KEY: misc-feature LOCATION 1. 432 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1028 ft. ft.
9 ft ft ft...
ft ft
ATI
4 AGAAGGA GACCAATCGT GCTAATGCAA GCTCTAAACA ATTGGCGATG AAGAATACGC GGCTACACGC GAGTCCCTGA AATGTCTTCC CTFI'GATCAG AAAGACACTC GTI'ATIGGT TCTGGACTGA TGCCATCCGA ATAACAATAA TT
GAGCAATCAA
AGAAGACAAT
CA'ITCCCATI'
AACCCCAAAC
TITGCGT'TA
GGTACGCCAT
ATCAGCATCC
TTAAAAGATT TAITTGAAAG ACAAAAAGAA GAAGAAATIT TGCAATTCAT TGGCTTTATT TTGAATATIT TAGAGATCGT CAAACCCATI TATGTGCTTG GCGTGTTCAA. TTTAAGGGGC AAGTF1'GGCT TGAAAGCCGA AAAACAAAAC AACGATCGAT CGCTGGGTTI' TTCATCGCI' ACTATI'GACC'CGTCGCAGAA ACTGTGCGCG INFORMATION FOR SEQ ID NO:1029: SEQUENCE CHARACTERISTICS: LENGTH: 897 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .897 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1029 TCGT1'CTCTA
AAAATTGTCA
ATCAGCTACA
GCTCAGTTAG
ACCCTTGAAA
ATGCTCTCTG
AATAATAATG
ACCGCACTCA
GATCccTATT
CTAATGGGCA
TITATACTG
AGGATTFI'AA
GATAAAAGAG
TACCATTCAT
GAAGAAAAAG
TCAATAGTI'
TGATGGTGTG
AGGT1'GAAAG
TCAGTTTTAA
GG77TTTTAAG
AGTTTITTGTT
AACGAATGAT
ATGAAAACAT
ATAAAGAGGT
AGAATCAAAA
ATGTGGTAGG
TCAACCCTAA
TCGCTAAAGC
TGAGCGGGAA
GGAATAACGG
TAAAAAGGCA
TGCGGTTGTT
CGTGTTGCAA
AATTCAAGGC
CGATGAAAAT
AGCAAACCCT
CACTGCAATG
GACCAACCAA
TAATGGCGAT
TGTTATAGGC
CAAGAAAAAG
TCGTGAGAT
TGTGGAGTAT
TACAGAAACC
CCAATCATTG
AAGGGAATGA
ATTGTCATTA
AGCCAAGCCA
A'FIATGAAGC
GGCGCTATTA
CATGTGTTAT
AACATGGATT
ATCCATTCGC
AAAATCTATG
GCGCTGAATT
AGCAACACCT
cAAGATAAGA
TACAATCAAA
TTTTTAGCCA
GCGTTGGGCA
AATCTACAAG
GCGCTGTTAT
CAGAATTGCT
GCATTTFI'AT
ATGACACCCT
TGGTTAGCGC
CAAAAATCGC
TCAAAAGTAT
GCATGGACAT
TCTTTTTAAA
TTITAATGGG
TITTAAGCGC
ACGAAGCGGG
TACAGCCCTT
ATTGGGAAAT
AATTGGTTCT
GGGCGIrTAFI
GCAAAA.AAAA
GGGCGCTAAC
AAAAAGACGC
GATTTATACG
CTACCCTAAT
AACCCGTTCA
TACCCTCCCC
CATTGACGCT
GAAAGACGGC
TATCAATCCG
CACTT1'GAGC
TGATFTTT
ATGTCAA
120 180 240 300 360 420 480 540 600 660 720 780 840 897 INFORMATION FOR SEQ ID NO:1030: SEQUENCE CHARACTERISTICS: LENGTH: 303 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .303 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1030 0* a a a a a a a a
GGGGTATITI'
TACCGCTT
AAAAATGCCC
TTI'TGCTCT
CGCATTGAT
CCC
ACAATAGCTC
TAAAGAGATT
TTAAGCTTT
TGGTTAAGCC
TGATI'GATAA
TCTCCCACAG
ATCACTTATT
TTTAATITrG
TTCTICTAT
GCATGTAAAG
CCCCCAACTA
TATGCAAGCT
TTACTCATGC
CTITITGAT'
GTTTATCATC
AAAACCCCCT AACCCGAGAA CTITTATTGT A TITATTTTA TTAATAAGCC AAAGCCTI'A TGGTGGCTCA rI'TGAGCACT ATCAAAAGCA CCACCACAAG 120 180 240 300 303 INFORMATION FOR SEQ ID NO:1031: SEQUENCE CHARACTERISTICS: LENGTH: 333 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: riscjfeature LOCATION .333 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1031
TI'TATCACTG
CATGGCATGG
cATGGCGTAA
AACCGAGTGG
GTGAGGATTG
GGTGCTAAAG
GGATAGAAAT
GTGTGGTGAT
CTCTGGGGG
TAGTITGGGGC
GGGCTAATC
CCAAACCAT
CCACCCGGGC
TGGCGAGACC
TACGGGCAAG
AGGGGCTAAG
GGTGGTGCTT
CACAAAGGAT
GcTAAGAT'G
ACAGAGAT'G
TTTAAGGGCA
GTCTTGGGCG
TCAGATT'AC
CGT
GGAGAGGGCT
GAGATGATGT
AACGCCACCC
CGATTI'GCGT
CCACGGGTTC
TTTATTGAT
TACCXTI'AT
TACTTTAGGC
GGGCGATGAT
TACGGCTGTA
INFORMATION FOR SEQ ID NO:1032: SEQUENCE
CHARACTERISTICS:
LENGTH: 1131 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .1131 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1032 e 55
AAAGGTTT
GTCAACTCCA
ACTAAACTCA
GCCCATGACA
ACCGTGGGCT
GCTAGAATGG
TCTGTAACTG
GTTGTTTT'A
AATGAAAAAA
AAAAATITTCA
TGCGGA.AAAT
ATIITTATTG
GGCTATATCC
GGGAGTGCTA
TrITTATGCG
GGCGGTCAAA
GTITI'AGATG
ATCTATCAAP
QAACGCTGTC
TAGGTGTIAA
AAGTGCAAAC
AAGACAACCA
CTGAGATCAT
TI'AGTTTGT'
TACTCCCTAC
GACTGATCAG
AAAGCCTTTC
TCACTCTCCA
ACCTCACCAT
CCACGCTGGC
ATAACACCCT
CCCAAAATAT
TAGATGAAAA
AGCATGAGGG
AACAGCGCAT
AAGCCACTTC
TCGCTAAAAA
AAGTCATCXI
AAAkAGITATT
GCTTAAAGTC
CGAAGAAGCC
TTACTCCACT
GATTTAGCG
CATFI'CTATG
CTATI'ATAAT
TAAGACCATC
AAACATTTCA
TCAAAAAGGT
GGATATTATT
'FrTAACCAGC TrACCTTT
ACGCTTGAI'
CCtTAAAACC
AGGCATCGCA
AGCCCTAGAC
TAAAACCCTA
TGACATGAGC
GrTTTATTA AAAAAAAGGG TTTTCAAAA' TTrCAGCAA
CACAAACTIT
'TGCAAGTGG
GTCGCTTACA
TATGCCCTAG
GAAATCGCT'
GTTGAAGAGG
F1'CGCTI'ATA
CAAAAAATCG
ATGGGGC'ITA.
GAAAACAGGC
GATGGCACTG
AAGGTGTGCA
CAAGTGGGCG
AGAGCCTTAT
AATGAAACCG
*ATCGI'TATCG
cAAcACAAAG
TCCCCAGGTA
TCTI'ATTCAA
CGCTTTATCG
ACAACCAGCT
ATI=AGTCCC
AGTCAAAACA
CTCTCATAGG
CCTACCCTAA
GCTCATGGCG
TGGGGGATAA
AAATGGCTCA
AAGGGGGCGC
ACGATAACCC
AGAGTAAAAT
CCCACCGCT
ACAATCTCGG
1GAGATGGTC
ITTCAAAATC
TAGCCGTAAA
TTCAATAGAA
ATACGGCGAA
CATACTCCCT
TGCAACCAAT
ITI'AGACTT
CCCGGTTTIA
CCATAGCGGG
A.AGTGGGGAA
TAAAAAAATA
TATCGcTTTIT
TATCTATGAT
TAAGCTTAGC
TGAAATTTTG
CATGGATGAA
AAGCACGATT
C
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1131 5*
S
INFORMATION FOR SEQ ID 140:1033: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 687 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geriomic) (iii) H-YPOTHETICAL: NO (iv) ANT'I-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 2 .687 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:l033
GCCTATAAAA
ATTTTIGACA
AACGATAGTA
TCAAGGAATG
GAAGAAATAG
AGGGGGCATT
TTCCATATCG
ATTACTAAGT
AATATCAFI'C
AATG-ATT'ATG
TTGAAAAATT
TTTGATI'TAC
AAGGGGAAAT
GCATGCATIT
AAGAGGGTIT
AAAAGATCCA
ATGCATTAGC
TGAATAGCGA
CTTCAGCGGC
ATTTAAGAG
AA.AAATACGC
AAAGCGCTAA
TAGTGGGGCA
AAAACTTCGC
CATGGCGCTT
AAAATATGAA
GAAACAATTT
ATATTrAT
CCTAGAGTTT
AGTGATGGCG
C ETGCATAGC
CGTTGAAGGG
CTATGACCCA
GGCTAATAAA
AGATGGCTAT
AAAAGAG
GAAGTGGTTT
GGGTTTAAGG
GAAGTTTATC
AACGAGATTT
GGCGCTATCA
TTTATTGATA
GAATTGCAAG
AGTCCGCCTG
AGCCGTATGC
GTGGCGTrT
CAAGGGAAGT
TATGGGATITT
CGTTGTTICA
ACTATCAAAG
TAAAAAC CCC
TAGAGCAAAA
AGCATTATCA
TG'ITGTGCGA
ATAAACCCAA
TAATGATAGG
TGGGCTATAA
ATTTGGAGAG
TGATGGCGTG
AA.AGCATGGC
TGGGGGGATT
TATCGCTCAA
GCTITI'TGAT
AAATTATATT
GTTTITAGGG
GA'ITATCGCT
CGATAGCGTC
CAGCAAGGTT
CTT1'AAGGGG 120 180 240 300 360 420 480 540 600 660 687
S
S. INFORMATION FOR SEQ ID NO:1034: SEQUENCE CHARACTERISTICS: LENGTH: 495 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .495 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1034
S
SS
555 5
AATAAAAGCA
GCACAAGAAT
GAGAGGGTGG
ATGTTTGAAA
ACCGGTGGGG
AAAATGGAT
CT1TI'GAATA
AAAAACGCTT
CTACAATTCA
TGCAGCAT'I
TGGGGCTGGC
GCTI'GAGCGT
AAAATTTGAT
GCATTGTGAT
TrGAGACCTT
ACCTCACTCA
CCTTTATCAT
TCGCA
AGTCTI'AATC
TTI'GAAATTA.
GAGAGGGATT
TGATGAA'ITA
GCATGAAAAT
GATTAAGCGT
AGCCAAAGAG
TGATGCAAGG
GGTTTTATGG
GAAGTGCTGG
TTTGAAGAGC
AAAACGCTCA
CTTAAGGGTT
TI'GAATCAAA
CTTTTTGAAA.
GGTGGTTTAA
GGAGCGGTAA
ATACGGATAT
TTGGCGAAGA
AAACCCCCCA
TAGGCACAAC
AAGAAAGGGA
AACGACAAGC
ATAATTCTIT
AAGCTCTCTA
GATCATI'AGC
CAATTTCAGG
TATCATTTCT
TTTACCTC
AAAACGCCCC
CCTCTATGAA
AAAACAAGTG
120 180 240 300 360 420 480 495 INFORMATION FOR SEQ ID NO:1035: SEQUENCE CHARACTERISTICS: LENGTH: 97S base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .975 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1035
ATITITTTA
ACCGAGTI'AT
GAAATCACTT
GCAAAAAGTT
AAAGAGCAGG
GAATCGCATG
TGCATTTTAA
TACCCGGTGT
AGGGTGGCGA
ATGGTCATGT
AAATGCATT
GTGTTCCACC
AFTITTGAAG
ACCATGATCA
GTGTTTAAAT
GGCGTGGCGG
CCCAAACGAG
AAGGCCITGT
ACGCCTACCT
TGGATI'ATIT
TT=rGrT
GGCATAAGGA
TCAGTI'AG
CCGACCCCTA
AT1GATCAAAA
TTGAAATCAG
AITTI'ATGAT
CTAGCTTTTG
CCATTGTGCT
AAGAAGTGT
GGTFI'TTAGG
TCAGCGTGAG
TGCTTI'TGAT
AACGC
GATGTTA.AGT
CACTTATG
AAACAGGCAA
AGACGCTAAG
AGGGCTATTA-
CGATAAGTAT
TCCTTCTAAA
TAACGATCTA
CTCGCCTTCA
ITCTATCATG
GACAGCGATC
TT2TAACCCTA
GGGTAAAAAT
CTCTATCA'T
CGAGCCGGAT
CAGTTTGGCG
AGAGACATTG
TIITCGCACA
ATCAGTAAGA
GGCATGCTCA
GAGCATGATT
TATTTTTATC
AAAGGGAACC
GCG~TTTGTGG
AAGTATTA
CTCACTITAG
GTGCATTTTA
GCTITAGCCA
AGCGGGGACA
ATCGCATIAG
AAAATCACTT
AF1'TATGTTA
TCCAATATTC
ATATCCGCAA
TGCAA.GCTGA
TGCTTAAGC C
TAACAGAAGG
AAGCCGTGAA
ATTTGGTAGT
TGTGCTTGCA
AACTITAG
TGTCGCTGCT
GCAGTTGA
CCTTTGATI'
ACCACCATGC
CCATTGAAGC
ATGCGGTGTA
AATI'CGCTITA
CAAGATCCGC
CCACCTI'CCT
AATCAAAATG
AAGCCAATTT
GATTGAATIA
TGAAAAGCGT
GAGCGCGTCT
AATCCCTTI'G
CGAAGGGAGC
TTTATTCGTG
CAFI'AAAGAA
GGTCAAGGCG
GATCCACCGC
GTTAATGCTC
TTTGGCTATC
TAGCGTGTTG
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 975 0 0 a.
0* U.
INFORMATION FOR SEQ ID NO:1036: SEQUENCE CHARACTERISTICS: LENGTH: 592 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: N0 (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .592 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1036
GAGAGTTATC
GTTGTAGGA
CAACGTCAC
AGGATCGCAA
GGATTTATCG
TTTAGGGCGA
cTTTGTC
TATTATTT
TCCGGTTAAA
GCGTTITTAAA
AAACGGTATT
ACCTGCGCGT
AGTAGCTTTT
AAACCCATTG
TTCCACCATC
TTTGTCTFI'G
ATAGGGTTI'
GGCATGATCA
ATTGCGATCG
GAAGAAATCA
TACACGCCAG
CTGTGAGTTC
CTATGGGGCT
TGGGGCAAGC
AAATCAT1TT
AGCCAGAAT
CTATGGCGTT
TGAAAACCCA
GGITTGTGGG
GCCTGGCCTT
AGGTATTATC
ACAAATCAAA
TACCATGGCG
CC2TTTATTG AITl'GTGGAT
AGCTAAAAAC
CCCTATI'TTA
CCCTCAAT'C
cATTATT1'TA
TAGCGTTATT
AGCGGTTGTT
ATAACAAGAG
AGTGCTI'ATG
TTAGCGATTr
CACAGCTTAA
ATTGTCAAAG
TGCTI'GGTGT
AACCTGCTCG
ATCGCTTCGG
AGTAAAATCT
TAGACGAGCT
GGGTGAFI'GT
ATCCCAT1'C TAATrAT'
AAGCCGTCCC
ccTITTCACA
TATTGAGCGA
CTATCGGGTI'
CTATCATGGG
TT
INFORMATION FOR SEQ ID NO:1037: SEQUENCE CHARACTERISTICS: LENGTH: 1332 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1332 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1037 5*55 5*S* 5
S.
5
GGGGTTTTTGC
AGTTTGGAG
AACGAAATGC
GATTATAGAG
AATT1'AGAAA
GCTGAAGTGT
GTGCTTTATA
GGTTTATTAT
GAGTTAAGAT
AAGCAAAAAG
AATGCGATGA
CCTATCACTA
TTTI'CATCTA
CTCGCTTCCA
AAGATI'GAAA
TCAAATTACA
GACAATGCGA
TTAGTGGTGT
TACTTTAAAT
AAAAACGCTI'
TGTITCACTA
GAGCTACCCC
GTTTCTCTAT
CGTTCGCTTA
GCCATTACCA
CCATAGAAGA
AGGTTTTAGC
TAAATI'CAG
AAGATTTGCA
TGATI'ITAT1'
CTCAAGTGAA
ATGAAATAGG
ATGAATCTCG
AGGGCAAGAT
TATTTGATCA
AAAATI'ATGG
AAATGCTFI'T
TCATTGAAGC
TCAAATACAG
CCAATAAAAG
CTTCTAACCC
TAGAGGCTAT
TCCATGATI'G
CCCCCCGAAA
CTTTTTTAAA
CTATTTCGTG
G TI'GTTACC
TTACCTCTAT
CAAAAGACGC
CGATATGGTI'
TTCGGTITCT
CCTCTTTTTA
ACGCT1'CGCT
GGATTTGGCT
GGTTrATTT
ACTAAGCTCT
CTrGAACATG
GAGCAATAAA
AATTGATGAA
GGATITTTGAA
CGATGACAAA
CAAACCTTTA
CAGCCAAGCC
GGGATI'GAAT
CGTTITTAAT
ATTTGAGAGA
GTTGTCGCTI'
TCTTCTCAAA
ACTATCAATG
AAAATI'GGCT
CACCAGTTGC
TTI'ATCCTTT
TATAGGAATT
TTTG'1rrI'GC
CAAGGGGATA
AACGAATG
TTGCGCTCTA
ATGCTCAAAG
TTGATI'GAGC
GAAAAATTIT
GATAAAAAAA
TTGTTTGCTA
CAGGTG TT
AAAGAAGATT
CATGGGTI'TG
?I'GAGCTATC
AGTITTACG
GGTGAAGGGA
TGTT1'ATGAT
TCAGTCACGA
AAATTTTAAA
TTAGAGAAAC
ACCACAGAAA
TAAAAAAGGA
ATTTCTrAGC
AGAGTTTATT
AAAGCGTGAG
ACAATTGCAT
TCATGCATGA
AAGAGCTGTC
AAITTTGCCCG
TA.ATGAGCGA
GCCCTATCCA
TAGCGTTAAA
TGGATTI'CAT
TTGAAAAGTA
GG'FTAGGCAT
ATTATAGCAA
ATTIAGAAGC
ATGAAGGGAA
AACGCTCTTrI
AAACTATCAA
TAACTACTCT
CACAATAGAA
TATI'TGGTAT
TGAGCATI'
CA'ITACGGTG
GCCTTTAAGA
TTGTAAAAGC
CCAA.AAAATC
ATTACGCACC
TTGCAAACGC
CATTGACCAG
TTI'GATAGAT
TGTATCCTCT
AAACATGATA
AGGGAATAAT
?1'TGCAACCC
GTATATCATI'
TGGAAGAATC
GGATAATGAA
CAGAAAAAGC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1332 CAATTGTGGG GT INFORMATION FOR SEQ ID NO:10 3 8: SEQUENCE CHARACTERISTICS: LENGTH: 990 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .990 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1038
AGAAAACAA
TTAAGAGCGA
GTCATAGAAA
ATGAGTATAG
GTTTTATTGT
GATCACATTG
ATAGCGGATT
GCTTCTGTGT
GAAAGCGGTG
AGAAAAGCAC
TIGCGAGCA
GATCGCAAAA
GAAGATGAAA
ATTGTTAAAG
GAATACGCCA
TAGAAACGA
AAAGAAGTGG
AAAGAGAGAA
TGGTGAGAGA
GCGATAGCGG
AGCCTCTTTT
TTGGCAT'CC
TC!GCAAAAGC
TGTGFITITG
CTAACGATAA
TGGATAITCT
TGGATAAGGC
GTTATTACGG
GCTATCAAAT
AACAGGGTGC
AAATCAGAGA
TGCTCAAACT
TGACTTGTTI'
CTAACTTTT
CATGTTCAAA
AACACGTTTA
TATAAAAAC
AAAAGAATGC
TAAACATAAG
TACGAGAGAA
CGAATACACC
AACGCTAAAG
AGCTCCAAGC
CGGGTATTTI'
GCCTTTAGA
GGATTACGCT
GGATATITTA
TCACACTTTG
CGCTCAAAAA
TAAAAGAGCG
ACAAAGGAAT
CGATTGAGAA
AATA'ITAATG
GAAATCAGCT
GAAGAATTAG
GACGCTACAG
ATTAAAAAAC
GACCATGGGC
ATITTTAAATC
AACATGATGG
CACACGCCCA
GATGTAGCCA
AACCAAAAAG
ATGGTGAAGC
CTCCCTTTAG
CACAACCTGA
GGAGCGGATA
GATTACGAAG
ATTrCATCGC
CCATGCCTGG
TGGGTTTAGG
GAAGCCATGC
GATTTAAGGA
ATTGCGGGAT
TTCAAGGGCT
ATGGCAATGT
TCATGAGTTA
ATTCTCCGCCC
AAGCGCTTTT
CGGCTTIAGC
CGCTCTATAA
TCAACTATGA
TGATTATI'AG
CAGCGAAAAT
TCCCTTATIT
CGTGTATCAA
CATAAAAGCC
GTTAAATAAG
TTTGATCGT'
TTAGAAAAC
TATFITGGCT
TTTAAGCITG
'TCCACTAAA
GAGTTITGGC
AGAAAGCTITG
GTATCTGGAT
TGTGAGTGGG
AAGCGTTITA
CTATCATGCT
a. a a a.
a a a INFORMATION FOR SEQ ID NO:1039: SEQUENCE CHARACTERISTICS: LENGTH: 1086 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1086 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1039
AGCGCAGGGC
CAAAGCGCTA
ATCCAACACA
GTTAAAATCA
TGCATGCTAG
GCATGGC
TGGACGGCTA
TCITTCCCGG
TGACTGGAGC
AGAGTCATAA
AGAGGATATI'
TGGGTTTAAA
GGATCATGTG
GATGGTGCCA
AGATCGCC
ATTTGCGTTC ACGCTTTGCC ATGCAAGACT TGGGCCAAAA AGCGCTITAG AAGTCAAAGA AAGGGAATAG AAACGATCGT CTAGCTCCTA AAGATITAA
TAAATTCAAT
AACTCAAGTI'
AAATGAATGC
TCCCATAGAA
AATTCACGCT
120 180 240 300
AATATCCGTC
CGTITGAATT
TTTAGAAAAT
AACGCCCTAG
AACTACAACA
CTTGAATI'GC
GACTTA
CTCAAACCTG
CCGGGTAATC
CGCTTATCCT
TTAAAGCTTA
AFI'CCTTACA
ATCGCTTTAA
GAAAAT
AAAAGGGCGA
ATGGCCATAT
TAA.AAATCGC
AGTGCCAGGT
CGCATTTTCT
AAGGCTATGA
AAGACGCTTT
GAAAGCCGGT
CTTTAAGTTG
TAAATAAAGA
ATAACAAACG
ACAACCGCTA
TTGATGAAGG
GAACGCTTCT
CGCGCTCATT
TCTCTTTIAGT
TTATGATGTT
AGGGGTI'TTA
TGTCATCCTT
GAAAGAAAGA.
AACTI'TAGCC
CTTACTGGTT
TrTTTAAXF1'A
GACGCATITA
TGAATCAGGA
AGTGGGATTG
TTAAACAGCG
GCCTCTCAAG
AGCGGCGATG
AATTCAGTGG
AAAGATGATA
TCAAGTGCGG
AACGCCCTTT
CAACTCAATC
TTACGAGTTT
AAACCCTTTA
ATCTTAGGCA
GCGATTCAAG
GTTCAGGGCG
FTTAGTCCC
GGTTCAAAGA
AATTAGTGCC
GTGTFII-AA
AAAATTTACA
GGGTGAGCGT
TTTATTACGA
AAAGCATTAT
TGATTCTACC
AGGCTCAAAT
ACTATTCAAA
CCCTI'GCGCA
AAATTGAAAT
TAAAAATACC
AATCAAAGCG
TTTAGGGCAA
CATGCTTAAA
GCTTAAAATA
AGGGGATAAA
AAAAGTCAAT
TATAGGCTTA
CTTATTGGAG
CAATGCCCCT
CCACCAATTC
AGTGGATTCT
TTTAAGGTTT
360 420 480 540 600 660 720 780 840 900 960 1020 1080 1086 INFORMATION FOR SEQ ID NO:1040: SEQUENCE CHARACTERISTICS: LENGTH: 633 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .633 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1040 fees .00.
06
GGGAATI'ACG
TTGGTGGCGG
TCCAAGAATFI
GTGGATTTGC
GATGGCTCTA
TTAAAACTTT
GATTITGAT
CGCTCITT
GATATI'TATC
CACAAAGAT'
GAAAAAAACG
GCCTAGAGAT
'FrTTAAGCGT
TGCAAGGGGG
CCACGAGCGC
TCCATTICTAA
CCCAACACAC
TITTAATGGC
TGTTAGTCAA
AAAACATGGA
ATTACCGCAT
GGGCGTATGA
TAGA TITTAAG G.AAATGGCAG TI'TATTAGCC AGAGACAACC C TTr AGCGGG ATCTATGATG TAGGATCTTA AAAAAAATCA AGTCGTGGGT ATTGATAAAA CC'ITAATCAA GACGCCTI'TG AAACAACACG ATGATI TG C TCCTTATAGA ATCGTGTTAG T ITAAACCAG AAGTFTTTTT17 CACGCTCATI' VTAGACGGGA ATTAAAACTG AAA
TGTTAAAAAA
CTTGAGCC
ACTACCTCAA
CGCTCACTTA
GCATTGAT'G
AAAAACGCTA
GTTCCCCTTA
ACACGCAAAA
CTCACATTAA
AATACCGCTA
GATGATAGGT
TGAAATCAAT
AGAAATCCAT
CCAAGATAT'
GCACTACCCC
CCAGATCCAA
TAAAATTTTG
AGGCCCTTTG
AGTCGGCACG
TCTITGGAA
120 180 240 300 360 420 480 540 600 633 INFORMATION FOR SEQ ID NO:1041: SEQUENCE CHARACTERISTICS: LENGTH: 1056 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO 765 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .1056 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1041
AAAGCAGTGG
GAAGCCCTAG
CAACGCCATT
CGTAACGCTT
TT1AGCGAATA
TGCATCGCCC
AGAGAAGCGA
GCCCTAAACC
TCTGTGAGCT
AAGTTTTTTIA
ACGCATGCGT
TTTGGGTTAA
TTAGGAGCGA
AAAAACGCCT
TTTGAATTGC
AAACCGGCGA,
TTGAAAGTCA
CAAGCGCATG
CTACGCCTCA
ACTI'TAAGGA
ACCCCAAAAT
TGAAAGTAAT
TGGAAGCGCT
CTTACTTGCC
TCAAACTCAT
AAGGGGGTTT
ATATTGAAGG
CCCCTTTT
TCAITAAAGA
AGGCTCATAG
TTAAAGGGGG
CTTCTAAAGA
TTGAAATGGG,
TTTTAGAGAA
CTACAATGGA
TGAGCATGCG
CCACACCCCC
AGTCAT1'CTA
CAAGCTTGTA
TGATAGCACT
TAAAAGCTrG
TTGCTATGAC
TCAAACCCCG
TAAAGATGAA
CACTAAGGAT
TAACCCAGCA
TAAGCCTATG
CGATGGCGAT
GGATATTGGC
GCTTTI'AAAA
AGCGACCATC
TTTGAGCCAA
AAAAATGGGG
'ITATAAACAA
TTATGGCTCA
GTTGTTAGCG
AAAGGCGGGG
TACACGATCA
TTTTTAACCC
ACAGCGATCT
CAATTAAGCC
AGCAGCGCGA
TTGCACAAAC
AAGGACACTT
GTTTTAGGGG
GCTTTATTGC
GAATGGTI'CC
ATCGTGTTGG
TTAGCGAAA
CTTTTGGGTr
TTCATTGGCA
GCGTGTATGA
AATTGGATTA
CATCAAGGCA
CCAGCGATGT
TCCAACAAAC
ATTATAACGA
ACACCAAAAC
TTTTACAAGC
TCACCACAAG
'ITATAGGCAT
GGGTTGT~i"'T
ATGCGGTTAT
CTGATAATGA
ATTTTCTCA
TCCCTAAAAT
TAGAAAkAATC
AACAAGAAGG
AAGCTTTAAA
TGTTTATATT
AGAATCCGTG
GGCTAGGGGT
GAGCCATTAT
GGCTTTAGAT
GCTCCAATCA
TTCCCTAAC
CGGCGATTTA
GGGTTTTGAT
GGATTGCGAG
TGATGCGATT
CCCCAAATAC
AAGCATTGGG
CACTCCTI'AC
TCAAATCAGC
GCTGTTAGTC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1056
S.
0 5000 00 00
S
9 00 0*00 0*00 0 0*S0 .0 0 0 000 0 INFORMATION FOR SEQ ID NO:1042: SEQUENCE CHARACTERISTICS: LENGTH: 615 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .615 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1042 TGCTTGGGGA TGTGTTTTAT TCTAAAGCCT TCGCTCAAGC CCCTCTCTAA TGCGGTTTA ?I'TGTGGGGG AATGTTTrAA TAGCGACAAA ACCCCCATIT TCATAGAAGC GAGCITAAAA AAAATGTATG CGGATTI'GG GTTGCATTTI' TTAGACATCA CTCAAGACGC CAACACTCTA GGCAAGACCA CTCTACCCTA CTTGCTTrrA CTI=IAATIT CCTATT1TCAA ACAAGATAGT TrCAAGCAAC ATGGTATCAT AGAAGAAACC GCCCI'GAAG CCATTAAAGG GGAAAACAAT ATT1TATAGGA C7I r TTTTGAGTI' GTCTAAAATG
AGGCTCTCTA
CAAAAATACT
AGCATGGCGA
GGCATGGCGT
GGTAAGCCCA
TATGAAAAAT
CATGAAATCA
CTTAAAATCG
TGATTTTAG
GGGGCGAGAT
GGCGTATTr TTCTI'rTAAA
TTCAAATCAT
ATITTTAGCGA
TGAATCAGCA
TAGAATGGAC
CTCAAGTFI'A
AAAAACTAGC
GGCGAATCCA
TGAAGACGTG
AGAAGACAAG
TAAAGACGCC
TGATGATTTG
T1-ITAAAGAG
TGAACAAGGG
TAAGGAAAAA
'rrCTAAAAAG
GCAAGATGTC
120 180 240 300 360 420 480 540 600 615 INFORMATION FOR SEQ ID NO:1043: SEQUENCE CHARACTERISTICS: LENGTH: 393 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 393 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1043
AAGAAGGTAA
AGCTTGAACG
GCCTATAAAA
GGGGTGAGTG
ATAGATTATA
GGGTGTTTTG
GAAGCCATTG
AGATGAATAT
CCCATTTATG
GCGGGAAT'A
AAGGCTGCAC
AAAAAGCCCT
GCTI'AGGGGG
ACGCTI'ACGC
CAAAATFF1'A
GGGGAAACAA
TTCTAAAGCG
GCAATTAGGA
AGAATA ITAT GCT1'TATGAT
AAGGCATGCG
AAAATATTAG
GACAATAGCT
GCGTCTTATT
ATCATI'ATG
AAAACCGCAT
GAGGGTTTAG
TTGGAGGGTT
TTTTAGGGAT
TTAAAAAAGC
AAAACGGGCA
GCCAGGCTGA
GCACGGCTCA
ATTTTTTITG
TGGTGAAAGA
ATGCAACGAT
AGGCACTAGA
TGATAGGGAA
AAATTATCAA
120 180 240 300 360 393 a a a. a a a.
a a INFORMATION FOR SEQ ID NO:1044: SEQUENCE CHARACTERISTICS: LENGTH: 717 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc_feature LOCATION .717 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1044 TCCAGCAAAA CAGCA'ITCAG AAACGCCAAG AGCGGCTCGC AGAAACCCCG TAGGCTCTAT AAAACTAAAC CCATTGTTGT AAAGCCACCT TGCTIITC ACGCTAGAGA GCGATCTCAA -rI'CTITFTA ATITTTAGCGA VI'ACAAAATI' TCTTGTATAA GGTCAGGTCA AAATTGAAGC
GGCAAAGCAA
TTCTATGGGG
CTCTCTTA
AGAATIGCAA
TAAA.GGCATT
AGAAGCCCTA
TGAAGAAGGG
CGCCATI'GAT
GTTCATTCAA
ATCATCACCG
AAAATITCAG
GCT1'CGGTGT
AAAGCTITAT
CAAGCCAACC
AACTGCTACA
TTFFFI'GACT
GCGATTGAAG
AATGAATITA
CAACCGATAT
CGCATITAGC
TATTAAAGCA
GGCGCGTAGA
GCACCAAGCA
CITACTCTAA
ITGATTTAAT
CCTAGAAGA
TTGTCITCAC
TAGCGCTCAA
CCATGAAATC
TGCGAACGAA
AAGGATCATT
AAGTITGAAA
AGACATI'GAT
GGGGATTGTG
GAGCGAACAA
CATTATTGAT
120 180 240 300 360 420 480 54 0 AATGGCAAGG AAGTGGAAAA TAAAAGCGCT 'ITATTTGAGC AAGGGGAATG GCTTAGGGTI' AGCCCTGTCT TI'GCAAGTCG ATGCGCTAT TAGAAAATCA AGAAAAAACC TTTGAA-ATTA CT ITT GAAAC CACTAAATA TTAAAGCCCA TGAAGGGAGC AGATTCTTAA CGCTI'CT INFORMATION FOR SEQ ID NO:1045: SEQUENCE CHARACTERISTICS: LENGTH: 465 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .465 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1045
AAGCCTAAAA
TTGCAAGCGG
GGCACCGATT
ATGTTTGATG
TCCGAAGCGA
GACATCTI'TA
TCTAACACCG
GCCAAG'ITGC
CAATTTI'AAA
ATGCGATCGT
TFITCAATGT
ATCTCGCTGA
TCAAACTCAC
AAGAAATI'CT
CCGAAAAAGA
AAAAATCCAT
AAAAGGACTT
GTI'ATTTATG
GCATA.AAGCC
AAGGATCGTT
TCGTGTTAA.A
AGAGGACTAC
AGGCGATAAA
TTGGATGCTA
TI'GATGAAAA
AAAGTGCATA
ACTGAAGAAA
CAATI'AGGAC
GAAGAAACTA
AAACACCTAG
GTTACCGTAA
GAAGCCCATT
CATTTGAAAT
ACTI'CCATI'G
TTTATGAAGG
ACCACCCCCT
AAACGAGCTT
AAAAAGAAT
CTTATGCGGA
TAGCT
TTTAAAACAT
GAATGTGAAA
GTTTGCGGAC
AGTCACT71'A
CCACTCTAAA
TAAAGAGCTC
CGATCAATTA
a. INFORMATION FOR SEQ ID NO:1046: SEQUENCE CHARACTERISTICS: LENGTH: 393 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE-! ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .393 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1046 GGAAT1'TGCA TGCAAGAAAA ACGACTTAAA GCCATTCAAA ACAAAATCGC AAGGAAATTG AAAGCGGCTT TATAGATGCA T1'GTTCTA AGATI'GGCCC CTGCGCTCCA AACTCATGCT CGCTTTGTTA GACGAAAAAA CAGACGCTAT AAAGCGCTCA ATTTGTGTGC GATrGTGGAA. ATGATACAGA CCGCTTCTIT a.
a a a
TTCTTGGATC
TCAAJAGATG
TTTATTAGAT
ATI'GCATGAT
768 GATGTGATTG ACAAGGCGAC CATGCGccGA AAGCTCCCTA GCATTAACGC TCTT-1"TGGG AATTTTAACG CCGTGATGCT TGGGGATGTG TITTATTCTA AAGCCTTFI'T TGAGTTGTCT AAAATGGGCG AATCCATCGC TCAAGCCCCT CTC INFORMATION FOR SEQ ID NO:1047: SEQUENCE CHARACTERISTICS: LENGTH: 1731 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .1731 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1047 0 0* 0 0 *000 0000 00 0* 0 *0 00 0 0 0*0* 0s 0* *00.
*0 0* 0 @0 0A** 0 .0 0 0
TGCATGCTAT
ITAAAAAGCC
TATAATTTCC
CGCATGCAAG
TGGGAAAAAT
AAAGACAATG
AATTTCATCA
CGTGATGAAA
GGTTATAGCT
GCTTATAAAG
GGGGCGAITG
ACGATCGTGG
AAAAGAACTG
ACCAGCGCTC
CT1'GTIAACA
GATGACAATT
TTAGAATTAA
ATAGGGCCTT
GAGGGCGATT
TTAAAAGGGT
TGCCCTAAT'
AAACTCGGGC
GAGCGGTTTT
TI'AGAGCAAA
GTGGTGATCG
TATGAAAGAC
GGGGCGAAGA
CAAACTTTAG
ATCAAAGACA
TTTCAAAACT
CTAAGCACCC
TACCCTTAGC
AGCATGGGGC
CAGGCCGTT
AI7rGTT
AAAGCTACAA
TCCGCCCAAG
TTCATGAAGA
AGATIAAG
GGGGGAGTAA
TGTGTCAAAA
AGCCT'ITAAT
CAAGCGTGGC
AAGTGATCCA
TAGAAGAGAC
GAGAGGCCAA
ATGGCTTGAA
GCTTGATCGT
'ITGAAAACCT
GTCAAGGAGC
AAAGCTATGC
TTGAAATGGG
AAAGCGATGA
TGGTITCTAA
TGCTCCAAAA
TGAGGGATTT
AGAGTAAGGA
TAGAATTAGA
TITI'GCCCCA
CGGGAACGG
TAAAAAAGTG
GCAAAATATT
GGATAAATAC
AAGTCCCACT
GCAATTACCC
A 1TCGGGITG
CGCTGAAAGC
CGATFI'GGGT
AAGCAGGGAA
TGCGATTAT
GTCCCCAAGC
GGAGTITTT
TAAAGATAAA
TAA.AGCCCTA
TGAAGAAGAT
AAAGCATGFT
TGGGGCTAAT
TGITTTATGCG
GTI'GAAATAC
TAAAAGCTTG
GTGCTATGGG;
LTCTAGCTGT
CCTGAAAGAT
GGGCGT'GAT
TGAATTGATT
ATI'TGAATGC
AGAAAAAATT
ACGCTCAAAG
GGACACCCCC
CTAGACAAAA
TTAATGAGTT
GGCAAGGAAT
TI'AGAAGAAA
GTGCATCTCT
GTGAGAGCGA
TTGGATAAGG
TGGATTTTC
TTTGTCGT
GCCCCCAATA
GCAITAGCGA
AAAACAGAGC
GAAACCCTAG
AACACTI'TGA
TTAAATAAAG
TGTTATAT'A
GAAAAGGAT
GATATTGTCC
CATAAGAGT
AAGGCTAGTT
ATAGGCATTA
GTGTGGACGA
GAAGCGCAAA
GCGCTGI'AG
GGGGAACGAT
ATCAAACGCG
TTAGAAATGT
AACCCCCAAA
TTCAAATAGG
TAGAAAACGT
TI'GTGGTTTT
TATTGGTTTT
ATATCACCGA
ATCAAATCCA
GGGAATITAT
AAATI=AAA
GCATI'GTGGA
TAACAGAATG
TTGAAATCGC
AATI'CCCCAC
CTTATITTTGT
CGTGCTTIT
ATCTITTGGG
CAGGGTTAAT
TTI'TGATGA
TI'CATGCGGT
AGGTTAAAGA
TGGAAGTGGG
TCTI'GGATAA
GCCGGTTGCT
AAAATACCGC
AAAAACTCGC
ATGACAGAGA
TAGCCTTGAT
CTAATTIAGA
TAGCGAGCGA
AGACGCCGTG
CAGTGGGATT
CACGCACAAA
GGCGAGITI'G
TAAAGACCGA
AATTGCCGCT
CACGAAAITC
CATGAAAGAT
CACGCAAAGC
AGCGGATAGC
CGGGGAAGAC
TAAACGCTCT
CCCTAATACC
CTTAAAAGCG
TGTTAGGGGC
GGCGAACGCT
AGCGGGCTTT
AGATTI'AAAA
GGGCGTGGAT
GAGCGATTIGT
GCATATTC
GAATGGCAAA
CAGCGTGATT
TCCTTTTGAT
TI'TTGAAGTG
CGCTCGTTT'
TGTTGGGAAG
AAAGCAAACG
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1731 INFORMATION FOR SEQ ID NO:1048: SEQUENCE CHARACTERISTICS: LENGTH: 552 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .552 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1048
A'ITCGTGAGC
ACCACTTTT
AAAGCGCGCC
AAAGAAGAAC
AAAAAGATAG
ATCAACCT'G
GGCGCGCTCA
ATITI'GCG
GACACTAAAC
CACAGGTTGC
TCTCCCTI'
AAGACACTGG
GATTGGACT'
AGCCTAGAGA
AAACTAAAGG
TCATGCTGCA
TGITFI
9
IATI'
GCATGTTI'AT
AATAATGACT
GGCGCTTCTT
CGCTAAGATC
TTTAAA.AGGC
GTATAGGGGA
CACTCAAACG
TAAGGCTAAG
GTTGTI'TTAC
AAGCGTTTTA
GCAATGATGC
TTTGCG0TTA
AAAGAATGGG
TTTATAAAAG
GCGITAGTCA
?AA.ATCAAGA
GTGGGCATCG
TTGAGCGCGT
ATAGGGAGCG
GTATTTI'CA
GTGGGCrI'TC F1TTAGAAAA
AAAACCATAT
TTGGCACGCC
CCATI'GAAAG
TGTITCAGGC
TTTTAATGGT
TGGTGTTCTT
CATCTATGCG
ATTGCTCTT
ATCCTTAAAA
CGCTATGCCT
TTTGTATGAA
GGGCTTTTT1A
GCTTITAGGG
GGCTTITAAA
TGGAGCGATC
120 180 240 300 360 420 480 540 552 999* 9 .9 *9 0 9099 9 9 99 0 9.
TATTGGTCTT TG INFORMATION FOR SEQ ID NO:1049: SEQUENCE CHARACTERISTICS: LENGTH: 270 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .270 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1049 I000 *00£0 0*
CTAATAAAAA
T LrGAAGCTT
ATTIATCAAG
TITFI'TGCTI'
TF'CTAAAT
GCAAATCAAA
CCATGCAATC
AGTTITACGA
ATGAATCTIG
TCGTGAGCCA
AAAGTGGCTT TGGTAGGGG AAGcGGCGAA
GCTI
9 FrAAAA ACGGATGGCG T'TTATTCTAA ACTCAATTCG CATAACGGGT TGTATTATCA CGCGTIAGGG TTI'AGAAAAG GGGGG'FrAAT
CAGGTTGCA.A
TAGTGAAATC
CCACAAACCT
GCCTAATGTG
TTTGGATAAT
120 180 240 270 INFORMATION FOR SEQ ID, NO:1050: SEQUENCE CHARACTERISTICS: LENGTH: 849 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 849 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1050
ATGCTAGAGA
GCCGTGATGA
CACATITCTT
TTAAATGCGG
TCTAGTAACT
TATGATI'TGT
GCTATCCAAG
GATCCCAAAA
TTAGTGCAAG
TCAGGCACGA
GACATCACGC
GACAATAACA
ACCATTGCCG
TCAATCTTGC
AAACAACAA
GCGTGAACGT
TTACAGCCTC
CTA'ITGGCGA
TAGATGGGAA
TGCTCTCAGC
TCCATAAAAA
TGCAAAACAC
CCATTCAAAT
AAATCCCCAT
TCGTTI'TCAGG
TTAAAATCAC
TGTCCTTAGA
GGGTGGTAAA.
AAGCCCTAAA
TAAAkTTCT
CTTGCCCCCC
TGCGAAATCC
TATI'TACGCC
CAATATCATC
CGCCATGACT
TI'TAAATAAG
CACCCGCCCA
TTACTACCGC
AGTGGATATA
TAAAGAGCCT
CACCGCTCAC
AGCCTTACAA
AAAAAGCGGC
GCAGACGATA
TTTGCAAGAC
ATTCAAGGAG
CTCGCTCAAG
AACGGGGCGA
TTAAGCCTGA
GTATTTGGTA
GAGCGTCTIT
GCGAAAAATA
ATCGTGCATC
TTAAATGATT
AACACGCTGA
AAAATTGGCG
GCGATTAGCG
TTAAATCTAA
AGGGCGATAA
GGACTTTAGT
GGGCTATCAT
CTATTGAAAG,
AAAACCCCAA
ATAAAGTAGC
CTATGGTGGA
AGATCATTGT
CTATAGTGGT
CTAAAAACAT
GTICTAACGG
TGAGCGCTAA
CGAAATGGAG
AAATGTCGCT
AATTGATATT
GATGACCCCT
TTICGGGTAAT
GGAAGTTTCG
TTTTAAAAAC
CATAGCGCTA
GITTI'TAGCT
AGATGAAAAA
TACAAGCCAA
GCAGGATTTA
GAAAAACATC
GGGGATGGTI'
ATACTATGAT
120 180 240 300 360 420 480 540 600 660 720 780 840 849 9S~@
S
OOS*
*6 0 S S S *0 S
S.
5050 0. Se S S
C
65 65 *6*5 S. S INFORMATION FOR SEQ ID NO:1051: SEQUENCE CHARACTERISTICS: LENGTH: 666 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .666 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1052.
OS
S S
S
ACGGGACATG
AAACAAGCCT
GTITCAATAC
TTAGAAATCC
CAGGAGCAAA
A'I'FITGTATI'
TTAATGCAA.A
ACGCAGTCTA
GCAGGTI'AGG
GGATTTATGA
GCCrI'CTAAC
AAACTTTTGT
TTGACGCTIT
TAGGCTATAA
ACATGAGCTT
AAATGATCAA
GTGGATATA AATCCAAAGA AGGCCAAGTI'
GCGCATGCTA
AGCCTTGTTA
GGCTAAATAC
AGATTCTCAA
CAACGCTAAC
GGGTITGTCT
TI'TAGAAAAA
TCTITI'ATAA GCGCGTI'TGA CTGCTTA GTF1'GGGTT CTTCTAAAA ATCAAAAAAT GAAAAAGTCG TTAGCAAATG GTGAGCGA'IT TFFICAGGCT CAAAAAGTGG AITTTAAATGG CAAAAAAAAA TATTAGAGCT
TATCGCACTA
TAAAAGGGGC
GGCTAAAGAT
ACAAGCCCTA
GGATAACCCT
GGATAGCACC
TAAAAAACTC
TAAAAAAACC
AAGCAGCAAT TGGTGATTAA TTTAATGATA AACGGCATTG GAAATAGAGC TTTTAAACAC AGCGATTAAA AATTTAGAAA CATrCCAGTT CGCCCGATTT AATAGCGATC GCCAAGTI'AG
GAAATC
AAAACTATAA AAACCAACAA ACACCCTCTA TCAAGCCAAC AAATTTTAAA ATCGCAATTA INFORMATION FOR SEQ ID NO:1052: SEQUENCE CHARACTERISTICS: LENGTH: 1041 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1041 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1052
ATTGTTITTC
'TTTAAAAAGA
TCTCTTrITAG
GCGTATTTCC
CCTACGGACT
CATGCGCTCA
ACCCCCCCAA
AGGCTGGTT'
GF1'CTTATTG
GTGGGGCAAA.
ATTTCTAGCG
TGGATGGGGC
ACCAAAGCCG
CCCAACGCTT
ACTTTAGTGT
GAATTGGTCA
GTAGCCATTA
TI'CAACGCTA
ATCAAGGGAG
ATAAGCGGGC
CCCCCTTGTG
CTATGTTTAA
ATAACGATCC
TCCCTTATAG
GCTTCAAACA
ATGGCTATCG
GCGTGAGTT
GGITGAGCGA
CGTTCAATTC
TTTCTCAAGT
CTAGAGCGCT
TAGTGGCAAC
CTTTGGATIT
ATCAAGGCAA
GCTI'GT1'GCT
ACATGCTCAA
TTTGAGCGTG
GGTGTTI'TCA
GGTCAATGAT
AAACTATGCG
TTATGTGCAA
CTACGATACG
CCTTAGGC
GGTTTCGT'A
GGGGGCGTI'
A.ATTTGGAGC
TAATITTI'GG
CGTGCGCACG
TGGGGTGAAT
GATCACTTAC
CTTAGGTTT
GGATAACCTC
TTCTGTITI'G
AGCGGTTIGT
CTCTATCTTT
CGCCCTTTAT
GAAGTGGAGT
AACACGCTI'
ATCATTATGG
ACAGACGATC
TTAA.AATGCG
TTATCGC'rIT
TCATCTATAA
TTGGAGGCGA
TAAAAGACGC
ATITAGACTC
AAGCCAGAGA
GTGTTTGGGA TTTTACTCAC CAGGGGTATT ATGGAGGGCT
GCGATCCCCA.TGCTTT
ATCATCTTGT TrTTTAGTCTr GAGTTITAA AAGCAAGGAA GA'ITrTAAAAA TCATI'TTCTA AFTCCTF~ TAATGGCGGC GGCATGCCTA TAGGGAGCGC ACCACGCCTC A TTAGCGGT GTGTTCATTG GCGAAGGGGT
TATTCTGAGT
GTI'AGCGCTT
AGACAATAAA
TITTTTCACC
TTTCATCATC
GCCTGCCCCC
CGTGITAGCC
CCTTTFAGC
AGTGGATTTA
ACTCATTGTG
GCTCTITAGC
TATGGACTAC
CCATGTTTTA
TAGTA~TrCC
GAGCTTGGGC
TGTAGCC'TT
GCGCGATGCT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1041 INFORMATION FOR SEQ ID NO:10S3: SEQUENCE CHARACTERISTICS: LENGTH: 1557 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE- NAME/KEY: misc-feature LOCATION .1557 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1053
AGGGGTTACA
CAAAACATCA
AGCGGGAAAA
AATGGCGAAA
CATTIAAGGG
TTGCATAAAA
CAAGTGCTCC
TTI'1'IGGATC
ATGGGCATTA
GCGCAAATCC
GCCCTTTTAT
GTGTTAAAAA
AAGCACGAAT
GCGCTAGATG
F1CTTTAGGC
AAAGAAAACA.
CTTTTAAAAC
TTAAATT1CTA
TACGCATCAT
GCTI'ACCCTA
GTGTGTTTAA
CAAAGAGTGG
CCAACCTCTG
CAAGAAAAGC
'FITrGCGATA
GAGGTGTG
TGCTAGAAAT
ATATTTCTT
GCTCTATCGC
TCCTGTTTGA
GGAATATI'AT
TCGGCAAGCA
TTAAAGAACA
GTTACCCTTA
TTAACGCGCC
AAAACCAGAT
TCATTAGCCA
AAGGCGAGAT
ATTCAAAACT
AGACGCT1
CITCTTTAAA
TCGGCATCAT
TCGCTTTAAA
AGGCGTI'CAA
TAAACCCTCG
AAGCTTCACA
ACCCTGAATT
CGATCGCTAG
CTAGACAA
AGGATTTGAG
GGGTGFI'AGT
ACAACCCCAA
CAAGAAITTA
AAGTTATAGT
TAATCTCGTC
AACAACCAAT
CGCTTACATC
AATGAGTGAA
AGTITAAAC
TGAGCTCAGC
AAAACTGCTC
rFI'AGACTTG
TGATTTAAAG
AGTAGAAACC
CTTGATTCAG
AGAGGTGAAA
AAA.ACCCCTr
TGGCGAAAGC
CAGCGGGGAA
ACCCTACCGC
C'FIAAGCATT
ACAAGAATGG
GCITAACTrT
AGCGATTGCC
AAGCATrCAA.
CTATTTGTT
GGTGAGTGAG
ACACGCTTAT
AACTGCGTT
GAAAGGGTGG
ATGCGATI'AA
CTTTTAAAGG
GCCCAAGACC
GCCTAFFTrT
GCCATGAAAC
GGTGGGCAAC
ATTI'GCGATG
CTCAAGCAAT
GCGGTTAAAC
AATTTGACTA
GCTTCAAACT
GATTTTAGCG
ATCGCATCGG
GGGAGCGGGA
GAAAAGATTT
AAGAITTTGC
CAAAGCATT
CACCATTTAG
TACGCTTATG
TTAAAACCTA
AAAAGCGTGT
ATCAGCCATG
GGGAAAATCG
ACCAA.GCGTT
TAAACTCTCA
CGATCGTGGG
ACCCTAGATT
AAAGCGAAGC
CCCTATCCAG
TACACCATAA
AAGTCCAATT
GCCAAAGGGT
AGCCTACCAC
TGAGCGTGGA
GATI'GGCTGA
AAGAGCTT':11
TGCCCGCTAA
TTAITACTT
TGGATI'TT'C!
AAAGCTCTCT
TAGGCCAAAG
AAATGGTGTT
TAATAGAA.GC
CTGAACTTrG
AGCTCAGCGG
GAATCATTCT
TGGAATTATT
AFITAGATGT
TGGAAACAGG
TGTITGGAATC
TTTT1TCGCTC
CGAAAGCGGG
CAAGCCCCAT
GTTCATGCAG
CCTAAACCCC
AAACGCTTCT
GGATGAAAAA
GTGTATCGCT
CGCGCTAGAT
AAAAAACATC
TAGGGTTTAT
TAATGACCCC
AAATTTAAAA
GCAAA.AACGC
CCTCAAAGCT
AGCGITAGGG
CGTGGGGCTT
TCAAGACCCC
TTTGCGC'rrT
CTTAGAAGAA
AGGGGAGCGC
T'ITAGATGAG
GTTGAAITA
GATCAAAGCT
CGCTAITGAA
CAGGCTT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1557 INFORMATION FOR SEQ ID 140:1054: SEQUENCE CHARACTERISTICS: LENGTH: 549 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (i)MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .549 (xi) SEQUENCE DESCRIPTION: SEQ ID 140:1054
GGGGGACITA
ACTCTAGCGC
AGCCATAAGA
TT'TTTACCCT
GAAAAAAGCG
CTCAGTGC
AAAGCGATGT
TGAATACTAT
AAACCCCCTC
ATTTAAAGCT
CGCCTAAAGA
ATAAAGCCGC
AAGCGCAAGA
TTr1'GCCTAC
TATAAGATAT
TAAAACCCCT
CAI'GATCCG
AACAGCGACC
TIGGGGCT'
ACTCAGTGTC
TITGAACGCG
GCGAGITI'AT
GATGAAATCA
CCGACAAGTT
ACGATCAATC
TATGAATTGC
AAGCAAGCGA
AGTTATAATT
GGGGCTTGTG
AGCAAATCCT
CTFIAGAAGC
AAGAGATCGC
TAAAGGGGGC
TGAAGAACCA
TI'AAAAATGA
TATTACTCTA
TAACAATTAT
GACACCGGGT
TAAATACCAT
TACCACCAAT
CACCATCCC
AGCTAGGGAT
ACTCCAGAAT ATAAGCATTA TAACACCCAA CAACTCCAAG TTI'AATGGCT TAGCAATGT GAATAATGTC AAAGAAAAGT
TGGCTAT
CTCAAGTCAC ATTGALATGTG CTGCGACTAC CGATCCACTG INFORMATION FOR SEQ ID NO:1055: SEQUENCE CHARACTERISTICS: LENGTH: 687 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .687 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1055
GTGAAATICA
ATTI'AAAAA
TFI'AGCGCTA
ATTTTAGACC
ATTTAA
AAAAAGCATG
TTGGGTGCTG
GCGTTGTGCT
TCTTTAGAAA
GTTITAAAT
CATGCTAAAA
CTTGATFAT
GCGTTTTAAC
GAGCGTI'AGA
ACAAATATCA
CTGAGATGAT
GCGCGGTGGG
TCGTTITGGT
ATGAGGTI'T
TGATAGATAG
ATGAGAGTT
CCAAAGAAAT
TCAAGCAACT
TCAAACAGCA
CCT1T71TCCCG
AAAAAACCTT
AAAAGCGGAT
AGAAAACGCA
CAAGCCTT'C
GTGCGGGCGT
TTGTATAGGC
TATCGCTCGC
TGAAAATAAT
CAATAAAATC
AAAGCTTGAT
CAAATCA
CAACTCATCT
TFI'GAATTGG
CACACGCTCA
CTCCACTCTG
AAGCAAATAG
TATGAGGGCT
GATTTTATT
CACATTCAAG
TATTTGGAGA
CCTGCACCTr
TTGTCAAAAT
TGCCTTATTI
AAGTGTTAAA
TTGGTGGGGG
TTAAAAACCC
ACGCGATGCG
TTGATGAACG
TAACAGGGGG
GGGTTFI'GGG
CCCCTAATT
TAGAATATI'C
TAAGGACAAA
TGAAGATTCT
CCTTIAGAGAT
TGCGGGGCAA
TAAACACACG
TTTGGCTCAA
CTCTA'ITGAA
CGAGCTTGGG
TAACGCCCAA
CGCTAACGCT
TAAAGGAAAT
ATUI'TACCGC
120 180 240 300 360 420 480 540 600 660 687 a INFORMATION FOR SEQ ID NO:1056: SEQUENCE CHARACTERISTICS: LENGTH: 1098 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1098 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:10S6
AGGGAGCAGT
CAAGGGAGCG
AAAAAAGTGC
GTTTTGGGCG
ATCGCCAACA
AGCGCGGGGC
GTCTTAAATC
AAAAGTGCGA
GATAGCGATT
CGFI'TTATTG
GTGGGGCGT'
TTAAACCCTA
AACGATT1TI
TCTATGATTC
TCTITAGAAG
AACCCCGAGA
GTGTCTGAAA
CTCACGAATA
GGT1'TCACTI'
GGAAGACAAC
TTTTATGCGC
AACAGGTGGG
ACGc2-rrAAA
GTTTAGCGAT
ccCATGAAGT AcACCTTTAA
CTAAAGGGGG
GGAGTGGGGA
TGATGGGGGC
ATGAAGCCAA
TAAACCAAAT
CAGGTTTAGG
TGAAAAAAAT
TT1'TAAACGG
TCAATCGCAT
AAAAGGGTAT
TCGCTCAACG
CACCACCGCT
ATGCGATTTG
CGTGGAAGTT
AAGGGCTAAA
TGATAAAGAG
GCTGTATGTC
TGAAGAAATA
TATCGCCTTA
AAAAATCCCT
TGGAGATATT
AGATTTAAGC
TGAAAAAGTG
GAATATGGCA
CAAGGCCATG
CAGCCGAAGA
CATCAAACGC
TAGCGATTTG
CCCCCCACCG
AAACTCGCCC
cAACGCTTAG
TTTCATGAAG
GAAGCOCAAT
CTTATGCAAG
GCAGACGCGT
GGCGTGAGCG
GGCATCACTT
GATFI'AGACG
ATCTCGCTCG
AAAAAGCTCA
AAA.AAT1'AG
AGCGCGCTAA
GTTAATI'CCA
AA'AAGGATCG
T1'GATCAGG
ATGAATCTAA
TGGTTITAAT
ACTATCTCAA
CAGCGGTGGA
AAAATAAAAG
TTGACGTGTT
AATTAAAGGA
TGAGCGGGCA
GGGTGGTGTT
ATCAATTGGG
TGTTTATGCC
CTGAAAAAAC
AAAAAGGGCA
GCTCTATGAG
AAGACACGGA
TGACGAAAAA
CTTTAGGGAG
CGAGCAAAT
TGAGTCAGGC
GGCAGGTTTG
AAccAAAAAT GcAATTAAAG
CGTGAAAGAA
AATCGTGGAT
AGTTAAAGAA
AGATGGGGTC
AAGCAAATTT
CTTACCCTTG
TGAAAGGATI'
CGCCAGCGTT
ATTCAC'ITTC
TTCTCTGATC
TTTAGAAAGT
AGAGCGAGAA
CGGCTTAGAA
GGCGAA.ACGA
TAAAAATCAA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1098 ACGCCCCCTA AAATGCGC S. *S
S
*5
S
S
INFORM4ATION FOR SEQ ID NO:1057: SEQUENCE CHARACTERISTICS: LENGTH: 810 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circu.ar- (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NANE/KEY: misc..feature LOCATION 1. 810 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:10S7
AGGAAAGCGA
AITGACTCTT
GATAAAGAAG
TACAGGTT
CAAAAGAAAA
GATATI'GCTA
ATCAAGCACA
ITAGCGTTGG
CAGATCATCT
,T7I7TATGAA.A
GCTTGTGGGG
CGGGACATGA
AGTAACGCTC
GAAAGCCAAG
TGAACACCCA
TAGAGCCGTT
CTAAAAATAA
CTAAAAACGA
TGAGCGAGAT
AAGAGCGATC
AAAGCGAAAA
AATTGGAAAA
TTA.AAAAGAA
GGATTAGGAG
GTTGTI'TAT
TCACT1'GTCC
AACCTCCAAA
AAGAAAGCCA
CCTCAAACAA
GATCAGAGAA
AGCGATTTG
GCAAACCCTA
CAAATCCGAA
CAATCAAGCC
ACAAGAAGTr
TTTAGTGGAA
AGAAGAACTC
GTGGGCGAAA
TCGGTTGAAC
GTA'ITGCGGG
AGAAAGCCAA
AGAATCCGTI
'ITGATTGAAA
AAACGGAAAG
AATITGGAAG
CAAGACACGA
AGGGAGTTC
AACAGAGAAA
TTGAAAAAGG
AACGAAGTCA
GTGGAAAA7A
AACACGAGCA
GATAAGATT
TTTCGCACTT
ACTI'GGATAA
AAGAAAAAI'
ACGCTAAAAT
GCTCTITAAA
TTGAAAACCT
AAATGCTAGA
AAAACATCAA
CCGAGCCTAA
TCGTAACGAT
ATGCCGAAGT
GGATAAAGAA
AGCCITGAAT
AGCCCTAAAA
CGCCAGTATC
CATTGAAGAA
GCAAAATGAA
GCTTGAAAAA
AGAAACCCAA
AATCTATAGC
CAAAAAACAG
GCTAACGAGT
TACGCATGAA
AAGCCAAGAA
120 180 240 300 360 420 480 540 600 660 720 780 810 CGTATIT1'AT ACGCTGAGAG CCAAAAGAAA GCCAAGAAGA INFORMATION FOR SEQ ID NO:1058: ji) SEQUENCE CHARACTERISTICS: LENGTH: 1701 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 1701 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1058 9
ATGAACGAAA
AAAGTIAAAA
AAAATTGAAA
GGTGAGCCTT
GATGAGGCGA
ATTGAAACGA
AAAATCACTG
GTTTCAG CC C
GTGGTAA.AGA
AAGCAGGTGC
GGCATGTCTT
GAGTATAAAA
AACGCTTTTG
TTAAACTCG
GGGGCGGTTA
CCGATTGAT
CGT'ITTAAAG
ATrTrl'GATG
GCGGAGTATG
CATCATGAGG
GACCCTAAGG
'FrTTCGCCCC
TACATGGTGC
GCCTTACTCA
GTAATACCTC
CGCATCCAAA
TCGACTII
GAAGAAAAAT
GAAAATTTGG
TTGACAAATC
CCCCAAAGGG
ACGCCCTAAA
ATATTGTCCA
TGGTGTGCGC
TTGAGCGAGA
AAATCAGGAA
TCACTTTTAG
TTAGCGACAG
GTATI'TCTAA
CAATCAAAAA
ATATTAAGGA
CGAGCAAGTT
TTACAAGGGT
ATAITGATGA
GCTACAAGGT
ATTACATCGC
AATCTI'CTGT
GTAATTCAGC
GCATGCGGTG
AATTTTACGA
ATGGGGACAC
ATAGTGATIT
ATCAAGAA T
GTTCATFI'G
GAAGAAACCG
TGGGCGCTC
TAACAGATTG
GCCAAACTCA
CGF1'GATATC
TGGTATTGAG
TTTAGCGACC
TCCTATTTGC
CGCGCTTTTG
ATTIGGGCAA
AGAAGAGTTA
AAAGATCCTT
GTTGCACAAC
AGAAACTCTA
CGAAITAGAA
GTAITTTGCAC
AGAAAAAAAG
GAAACGCCCT
AATTTTGGAC
TTTAGGGATI'
TTTGCCCAAA
F1'ATGAAGTG
CCATTGGAAG
GI'GCAAAAT
ACTCGCTAAG
TTACACTA
GGGCGATAAA
AAGGAGTGGG
GATGGATCAG
CTTGAAAGAA
TGTTTTTGAA
TGGGGTGGAG
GGATTCTTAC
GTT TTAAGGA
AAAAGCCATA
GTGGCGAGCG
CATGATGTGG
GATGTGGCTA
GGCGTGAGTT
ATTAGCGCGA
ATGCTCACCT
GCGGTGTATG
GACAAGAGCT
AAAAACAAAC
CTTTGACA
TATTCTATTT
'FrGTTAGCCA
AITCATITGA
GAAAATGGCT'
CAGATCCGCA
TATAAAGCCG
'I=AAATACC
AACGATTTGT
CCGGTGGGCG
GCCACGGACG
GATGTGGTTA
CTTAAAACI'
ATTGACACTA
GATGCGGAI'
ACCACCTI'AA
GGATTCTGGA
CTTTAAT1'GA
AGGGGCAATA
TGGTGGCGT
TAGAAGACAC
AITTAGTGGA
CTCAAGATCC
TACAAGATCC
TAGACGCCTT
CCCCCATAGC
TWI'ATTATAT
AGTCTI'TACT
GCGGGTTTAG
ATCTI'AAGAT
TAGGATITT
ATTTCAAACC
ATAAGACAAT
CITTTGATAT
GGGGCGTGGA
ATGACAGCGA
ATCGTGAAGA
CGATCGCTTT
CTI'ATATCAA
AAATCATTAA
CTAAGGCTAA
AGAGCATGAT
TGAAAGATTA
CAGAAGCGAT
TGTTATTAAA
TTICACGCCC
CAGAAAGAGC
TTGTGGGGGC
GCCTTGTGAG
TGCGCTCACC
CAGAATGGTG
AAGAGCCTTA
GCCTCATGAC
GAGTCGATIG
TI'ATCCAGAA
CTTAAAACTC
CCAI"ICGGAT
GCAACGAAAA
AITGAAAAAC
CATTGTTI'CT
ACACACGACG
GCACATGGGG
TCATGAAGAA
TTTGAAAAAC
TATI'GTCGT
AGATTTCGCT
TAGTAAAAAA
AGGCGATAAA
AAACCATTIG
CAATATCTI'A
TAAAAAC'II
GAAAAGCTT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1701 .00.
*.00 INFORMATION FOR SEQ ID NO:1059: Wi SEQUENCE CHARACTERISTICS: LENGTH: S94base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .594 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1059
GTWACAATCA
CAAGCGGGTT
GACATTCATG
GAAGTGGGTA
GGGATCATTA.
GTAGCCATGC
GAAATCAAAG
GGTAGGGTGG
GCTACTTTAA
GGCATCTATG
AAAGCTI'AT
T1'GGTGAAAT
TGTTAGATCA
TTGTGATTGG
GGCGCACCAG
AAGAAGCTIT
AGATTrGTGA
TGATTI'ITGG
GAGCGATI'GA
ACAAAGACCC
TAATGGATI'A
TTTCTGGGGA
CATCGCTAAA
TGGAGGCAAT
TGGGGATTAT
AGAGCATATC
AAGTTATATI
CGCTGGCACA
AATrGGATCG
TAACAAATTC
AGAAGGGATC
AGCGTTAGCT
GAGATCAGAA
ATCATTAGGG
ATGGGCATGT
GGTTTAGACA
TATAGGAA~AG
GGAAACCCGT
GATCTAATCA
AAAGACGCTA
ATGCAGGCAA
GGGGACAACC
GITTAGTGGA
GGGTTAGCGC
TAGCCACCGT
CAAGAGTGCA
CGATCAGGCA
'FFITCACCAC
TTAAAGCGAC
AAAATTGGAC
AGATAAAAAA
AGTI'TGGATT
AAACGATATI'
GGCTCAAGGG
GATTAATGCG
GAGTGCCATT
TTTAGAAAAG
CGATACGGCC
TAAAGTGGAT
ACTT'
120 180 240 300 360 420 480 540 594 0* *4 9 9 9*6* 9.
*9 9*9* .4 .9 INFORMATION FOR SEQ ID NO:1060: SEQUENCE CHARACTERISTICS: LENGTH: 1017 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .1017 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1060 0 09
ATGAATGCAT
AGCCCAGCGA
AAAAACCGGA
GTAGCGTATG
ATCATGTGGC
GTGATTGGGG
CCCATTGTGG
AAAGGCGAAA
TI'ATTAGATG
AATAAAGCGC
CCTAAAAGCG
GTAAAAGGGA
GACACCACAG
GCGCCTTTTG
AGTTTGCATG
GGCGATGGCG
GGGGGGGATA
TGAAGCGTGC
GCGACGCTT
TTGAAAATTA
TGGGCGATGT
ATTTTGGTAA.
GGGTGATCGC
CTGATGTTAA
TCACGCTGAA
AAGTCAGGGC
GTAAATIT
ACGCTAAAGG
TCTTACCTGG
GGGCGATGAC
TGTI'GCAGAG
CAACCTITGCC
TGATCCATAC
GCCACACCCG
GTGITI'AAGA
CACACGGAGC
CGAACAACGC
GGTTGGCACA
GGACATTCCT
TCCGATITI'C
GGATI'FGAAA
CGATAAGGTG
TTCTGGGCGT
AGGGCTAGGC
CTACACTFI'A
TGCTI'ATTGT
CAGAGATGAG
TTTITGCCAT
TGGCTTTATC
ATGGCTI'AAT
TITCCCTr1'A
TTGATGGGCG
GATATTCCT'
ATTGAAGCCA
GGAAGCTCTA
'DTTGTGCCTA
TITrGCGACTI'
GAGGGCGATA
GTTAGCACCT
ATCCCCTI'AA
GAATCGGAAG
GCCCAAA1AJi
GAGCCAAAGG
GTTAAAGAAT
ACCGCTGCTT
ACTCAAAGAG
CGCATGGGAT
GGCATCAGTI'
AAACCAATAC
TACACGCCAA
TTAAA.ACTAA
GAAAAJAGCGC
ATAAAAGGAG
GTGAAGATAG
TCATTAAAAT
TI'AAGCTAGA
TCAI'GGTAG
CGTI'CAAAAA
TI'GTAGGCCA
TTACCACCGT
TAGCGAGTFI'
ACCCAAAACC
GGGGCGTGGC
TGCCTGACAC
TCCGGCAGGG
CGATGATI'TA
AGCCATGCTA
AGGCGTTCCT
GACTAACTCT
TGGAGGCAT'
CGGGGCGTTA
CTACCCITAT
GCCTGAAACT
GGGTTTGACC
ACCATCCGCT
TGCTTGTGGG
GGGCAGTCAA
GAAATTTGAT
TAGTGATGTG
GITGCATCCG
TT'TAGGCACA
AGCGGGC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1017 INFORMATION FOR SEQ ID NO:1061: SEQUENCE CHARACTERISTICS: LENGTH: 462 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .462 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1061
ACATTTACTA
GCCCTTATCC
GAAGTAGTGA
GAAGTGGGGT
ATGGTGTI'AA
TTAGCGAATT
GTGGTTCAAA
AGGGGTAGCG
TAAAGAGATT
CTAAATACCA
TCAAACCTCA
ATGAACTGCA
ATTCCCCTGG
TGAGCGATAA
AAACTI'ATAA
GGGGGTITGG
TGT1'TGATG
AACCGAAGGC
TAGCGTGGGA
GGTACGCACC
CACGGTGGAT
AGATTTTAAA
AGCCGAATTT
CAGCACAGGA
AAAATTAAAA
TCTTCAGGCT
TTGGTAAGGA
CGTAGCGGCT
AATGATTATA
GTTCAAGTAG
ATAGAATGCG
GTGAGTAAGG
TCCAAAAAAT
TTGATTTGCA
TTGGGATTIG
TGGCTTTGAA
GGGGCGAAAT
GGGATAGGAT
AAcAATTAGA
CA
CCACCCAAAC
CGcTGTAGAA
TTTGTCTTTA
TCATCAGGTG
TAAGGTCATI'
CGCTCAAGGG
TGAAACTTCA
a INFORMATION FOR SEQ ID NO:1062: SEQUENCE CHARACTERISTICS: LENGTH: 525 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylon3 (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1 .525 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1062 a.
a
AGAAAGAAAC
ATAGCCCTAA
CAAATI'AAAG
CGTTATGGAG
AGAATTIGGTA
ATCCI'GCAC
AAGACTGAAG
TGTCATCAAG
CCTITGGAGA
CAT1'CAAGGA
TTGCCTTTIAG
GCGAAGCGTA
CCATTTTGAA
AGAAITTCAA
AAGATTGT
AAACGGAATIT
TGGAATTGAT
CTTI'TGCCTT
ACGCATI'GAT
CGGCTGTAAC
TFI'CCCTAAC
AAATGGAGCG
TTATGAAAGC
GAACAAGAT
GAAATTA&AG
TAGCAATAAC
GGCGCGAGCG
TrGATGAATA
ATGAGAAAAT
CATTTGCAAG
GTATAGGCG
AGTTTITTAA
GATAAAAAAA
GGCGTTGAAG
CCTAACGCCA
TTAAAGGGAA
AAccATIT
ACTTCAAACC
AAAGCATCGT
ATAAAGGTFI'
ATGAGAGTCA
CAAGCAAAAG
CGGAAGTCCA
GCCAACAATC
TCTIT
AATCTTACTC
CGCTAAACAC
TTCGTCTAAT
AACGCAGCTA
AGGGTITTTC
CAGGGCGGCT
AGATAAAGTC
TATCGTTATI'
120 180 240 300 360 420 480 525 INFORMATION FOR SEQ ID NO:1063: SEQUENCE CHARACTERISTICS: LENGTH: 657 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscjfeature LOCATION .657 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1063 o o 00
GGCATGAGCA
CTTTTAGAAG
TTATCGTGG
GAGCAAACGA
ATAGCCTTIGC
GCCAGAGCGA
GAAATCGTTA
CTTGAAAAAA
GAAGAAAATT
AGTTCTTCAC
CAGCAAAACC
TTAAGGAAAA
GAGCGTTTAG
TGGCTTT1TAT
GAGAGCGGAT
AAAAAAGATI'
GTGAGAGGAA
AAGCGTTCGC
GCCCCATTCT
CTAAAGACGC
TCTATGCTAT
CTTCCAAACC
TTTAGAGCAA
ATI'AGAAALAG
CGC?1'ATTTA
CACTCAAAT
GAAAGAAGTC
CGATGCAAAC
CAAATATTCT
TAAAGAAATG
AATCAAAAAA
AATCTCTGTT
AACCAATCTA
GTTAGAAACG
TITTTCAAAC
GGGGATACAA
TATAATGAAG
GCCCCAGAGT
GAGTI'AAA6A
TACGCATCGC
AGCGCTTTAC
GCGCATCAAA
TTAAAACATT
AAGAAAGAAA
AATTTAAAAG
GCTACAAGTG
AATTACAAGA
TGCTAGAGAG
TGTATGACTT
GGCTTTCGCA
TCTCTAGAGA
AAGAAGTGAA
GTTTATCAAC
ATGGAATGTT
CCATTCAAGG
CGATGAAAAG
GGTGTTGTTG
TTATAAGCAT
TCCTAATAA.T
GTATCAGTTC
ATCTTCTAAT
TAAAAACCTG
CTTGTTGTAT
TATCCCTCTA
AGAAGATATT
AACGCAT
120 IS0 240 300 360 420 480 540 600 657 INFORMATION FOR SEQ ID NO:1064: SEQUENCE CHARACTERISTICS: LENGTH: 594 base pairs TYPE: nucleic acid STRANUEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FETURE: NAME/KEY: misc_feature LOCATION .594 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1064 .0 0
AAGCGCTATA
ATAGGGGITG
TATGGGGTGC
TTGAAAATCT
AGCGAAAAAA
TTAGCCATTC
GTCAAAAGAC
GATTTGATIG
AAAGGCTAGA
TGGAAAAAAT
AAGITI'CTAT
TACAAGTGAT
TTCTCTTTGA
TCAAGCT'
TCCAGCAAGT
GCTITTTCAT
GCAAGAAATA
CTCTGCFFI'A
GCGAACGGCT
TAAAGAAGAT
AAGGCT LTTG T1'CGCCGAAT
CCCAGGCATA
TcAAGATGAA
AAAAAAAGGG,
GAAGCGCATA
GCI'TGCTCC
GCGCATCTTT
AAAATCAATG
GAATI1'GAAA
GGGAAAAAGC
AACAGACCCG
ATAAAATGAT
TAGAAGT1GCA
AAACGGGCCA
TATACGGGTT
GGGTAGGGGG
ACAT1'ATCGC
TCGCCGATAA
CGCGCA.ATGA
AGTGGGTITG
AGGGGT'GT'
AAAAGCGCGT
TTTAGAAGAG
GCGTATCGCT
TACTAAAGAA
GATCATGGTG
AGTCTT1A 120 180 240 300 360 420 480 GCCCTAGAGA GTT GGCTT TAAAAGCGCT GAAATCAATC CAGTIT AAA AACCCTAAAA CCCCATCTCA GCATAGAGGc AGCGAT1'AAA GAAGCCTTAC AGCAACTGCG CTCT INFORMATION FOR SEQ ID NO:1065: i)SEQUENCE CHARACTERISTICS: LENGTH: 1221 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (i)MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1221 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1065 9 9.
9**9 9 9 9 9* 9 9*99 .9 9* 9 9 999 9
AGTCGCACCC
CAAACACACC
AGCGCCATAC
GTTGGGGGTA
CTCAAACAAG
CAAGCAGGAA
TTATCCAGTA
AAAGGCGGGC
CTATCAGGGC
TTGCGTITGG
ACCACGAGAG
AATCGTGTGG
TCAGAAGGGA
AATTTGGCT
GTGGGAGCGT
GTGGATTTTA
AGCAATAAGA
GCCCCTCCAG
AAAAACGACA
CCCAATAACA
AAGGCAAAGA
TI'TGTGCAAA
GCAAAATCAA
CGCAAGAGAG
TCGCCACAGG
CCGAAGAAGC
AAGGCTTI'AA
AGATTGATGG
AATGGAACAA
TTAGAAACTT
GCCAATTCAA
TGAA'ITTCAA
GITCTGGAGC
TCACTAGCAG
CAAACAGCGT
ATTTAGCCCC
ACCATCTCAC
CTCATATTGG
AAGGTGGCTA
AGAAAGAGAT
CGCAAAAAAC
CTCGGTI'GTC
AATCGTTA
TCGCCCTTTA'
TCATGCCGCC
CACTGCTGTA
GAATAAAACC
TGAATTI'CCT
AGGTIGGGAC
GCTI'GAAGTG
TACTGGTGGG
TGGCAATTCT
CGCTAAAAAT
CGGGAGAAAA
TAAAAATGCG
TAAATTAAAT
TTCATACAGC
TGTGGGGGAT
CACACTGGAT
CAAGGATAAA
CAGTCAAAAT
AGAAACTGAA
CAAAAAGAAA
GTTITCTCTCG
TTTTTCACGA
GGAACGGTCT
CCAGATAAAC
AACAAGGAAT
TGGGGGAACG
GATATGAAAG
GATI'TAGACG
TTCACAAGCT
AT1TCAATTG
GCCAGCTCTA
GAAATIrCTC.
GGTAATGTGT
ACGATCAACA
CAAAACGCCG
TTGTGGCAAA
CCTAATAGTA
AACAATAGCA
CCCACCAAGT
GGAAGAAAAT
TITI'AGCAGG
CCGTGATCAT
CAGGC-CTICT
CCGATAAAGT
ACGACTTATA
CCGCTAGGCA
ACGCTGTAGG
TGAATATGCA
ATAAGGATAG
ATAATTTGT
CGGTTITGAC
TITATGATGG
GGATGGGCCG
CITCAAAAGT
CTCAAGCGGG
GCGCCGGGT
CCACTTCTCA
ACACAGAGGT
CAT1'GATGGG
GGAAATACAA
AGCG'FrGATr
TCCAGCCATT
TAGTTGGGGA
TTGGCGCATr
CAAATCCCTT
TrATTGGGTC
GACTI'ATAAA
AAAAGCCACT
CGCTGATCGC
AGAAATCAAT
TTTGCAAGCT
CGCCACGCTC
TTTGCA.ATAC
TCAAGGGGAA
CATFTATCGCT
AAATATCAT
AAGTGGCACT
CATITAACCCA
CCTITTTGCTG
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1221 INFORMATION FOR SEQ ID NO:1066: Wi SEQUENCE CHARACTERISTICS: LENGTH: 1278 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: 1-elicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1278 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1066
GTAATAAATA
TGCTCTAGGA
GTGTATAGCG
GCGGAGGGCT
GGTI'TTGCGA.
GTAGCGCTCA
CTCAAACTAT
ACCACTTTTT
GCAAGCTTAC
TTAGAAGCGT
TTACACITT
GGI'TTAAGA.
CTAAAAGCGT
GCTTCTTTT
TATTACGCCA
GCTCTTrI'CC
CGCTTGCAAA.
ATAATGTTAA
GACACCCTAA
CTAACCAAAC
ATCTCTTTAA
GGGGTTTTGG,
CAACTAGTAT
TITI'TGGCTT
ATATTITCTT
CTTTTTCTCA
GTTTGGTGGG
ATCCCTTATG
GCACCCCTAT
TAGGCGCGCT
TCAXITI'ATG
TGTAT'AT
ATCCTTTIAGT
CTAAAAATAC
ITITCAAGCA
TAGACACCAC
ATAGAGTCTT
CTAGCATI'GC
AGGCGTGGTT
GCAAAGAAAT
TCACTTCGCA
TCTTTT1CT
TICGCTI'T.
GTTTGCGT
GCTAAAAAA
TTTACGGGAT
TGTGGCTITC
AAGCI'TTTA
GCTTATrTTT
GCTAACCAAA
TGTAGCGATC
FITACAATAC
CATGATTTI'A
GAGCTATGGC
AAAATTAGGC
AAACAAAAAA
ATTCTTCCCC
AATCGCTTCT
CCAGCTCCCT
GATCGCGCT
T'FTI'TGGTG
CACCGAACTT
AGTCTTTTCG
ATGGCTITAT
TTTAGGTTTA
ATATTTFI'AA
ITAATGATGG
AAATTGCCTA
CCGAGCTTCA
TGTGGCGTT
CTCCTAGC'T
AATrTTI'GGT
AAACACAGCT
GCCCTTTrGA
GTGCTTAG
TTATGGGATT
GAATATCGTT
AGCGTCTTAG
TCTGGCGA
TTAGCCFI'AT
AAAAACAACC
GGGGTFFI'GC
TTATTTCAAA
CTCTATCT
GCGAAA'ITAG
GCGGCTT1CTT
CCAACAGCTT
CCAATATCCT
ATCTATTCAG
TACGGAGTTC
TAFI'CATGTG
ACGGCITTTGA
ATCTTTTATT
TTTTTGCCAG
'FICTAAAGA
GGGGCGTGGC
TATI'ATTTAA
TGAATAGGGC
GCAATTCTAG
GCGGGAGCGT
TCGCTATCGC
AGCAGGATT
TTCTFI'GCAG
GGGGGCAAT
TAGGCTTGCT
AGCAAAAAAA
TGAGITI'AAT
AGGGATTA
AGGGGCTGGG
GCGTATTTTT
CATAAGGGG
GTGC'FTAITA
TGAAGAAACG
GGTGTTITATC
CGCTTATAGC
AAAAACGCAT
TCAAATCTTA
AGGGTTGTTG
TAAAAAGGAT
CGCTCAGATC
GTC'ITA'FTG
TATCTCCACA
AATCTTACAA
CATI'GGGGGG
TAG CC CTAAA
CCCTTTI'GGG
AGCGGCTAAA
GCCITTGITA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1278 a. a INFORMATION FOR SEQ ID NO:1067: SEQUENCE CHARACTERISTICS: LENGTH: 738 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc_feature LOCATION 738 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1067 a a a
TI'TCGCTI'AC
CAGCAITTAG
GTCAATAAAA
CTCATCGCTC
GATCATTA
TF1'AGTCAAG
ATGCAATI'AG
ATTAGAGGGT
T'CTTTATAI'
CCGCA.AT
CAAGTCCCCT
CAAATAGCAG
TGGTGGTTTC
CCAATCTAT
TAGATTITAA
TGGCTC,.FIT7.
ATGAAAGTIT
TTAAAACGCC
GTATITI'AGA
TI'GAAGTGGG
TACCTCAATT
AGAAAAAGCT
TAAACCCTCT
CGTI'AGCAGG
AGAAAAGGTT
AAAAGGGGCT
GAAAAACGAC
AGAAAAAATT
AGCGXTTTG
CAGAACAATA
TTAATGCGCC
AAAGCGTTGG
TFI'ATCGTTA
GCTGGGGAAA
GTTTTAGATG
AAAAAGGTGC
CAACGCATAG
GATITAGCAC
CCTTTAAGCG
AAACGCAATA
TAGAITACGC
Trrl'AAAAAA
AAGAGGGCGA
AATIAGGGGC
TGGGAGCGAG
TTTGCGTGGA
AATGrTACGA T1'TGTGATGT
GTGAATTITT
AAALAGGGGGT
CCTXITCAAC
ACAGGTITTA
TCAAATTGAA
TI'TTTI'AGAA
TAAGGGAGGC
TGTGGGGAAA
AGAATGCGAT
GAGCITTAT'
AACGCmT"11C
GGTGATGGAT
AAAGAAGCCA TTTTGAACGC TTAGAAAAC F1'TAAAAACC A'FITAAAAAC AAAGGATT CAAATCTTAA CGATCCAAGA AAGCTTAGTG AAAGGGAAAA ACGGGAATGT TGAATTTTT ATCCA TTI'CA AGCGAGCC 660 720 738 INFORMATION FOR SEQ ID NO:1068: SEQUENCE CHARACTERISTICS: LENGTH: 2547 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .2547 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1068
AGACATGTGC
TTAGCGTTT
GTGTGGTTG
TATTTGGCGT
TTAGAAAAAA
CTGTI'GAATC
GACTTTGGGC
AAACTGCCCC
GAGATTTACA
TTTGAAAACA
AACCTCAAAG
GCGATCCCTA
CAAATTI'CCC
GATTTGACTA
CTAAAAAAAG
GAAAATCATG
TTACAAGAAA
AAAGAAACGC
GTTATGGTTA
GTGCAAAAAC
AAAGAAAC'T
CTGCGCACCT
ACCTITGAAT
GATTTAGCGA
GATGTCGTTG
TTAGAAAGCG
ATTGTGGGTA
ACGACAGGGA
AACCCCCCTG
TATGCGGACA
GCTTTGCAAA
GTIAAAACCA
TA'I-I-GATTG
GAGrrTCCTA
GCGACCCAAC
AGGGTGAG71 GCGCAAAGC7
AACCGATGAA
TAACCCTATC
CCGCAATCAA
GGGTTTTATT
CTTTAGGGCA
AAGGGGAAAT
FF1ATGTGCT
CTAAAAGCGT
AACAATGCTT
CCCCATCAGA
AAAACCCTAT
CCCCCTATAA
CACACCCCCC
ACCCCACTTT
AAACGCCCAC
ACAAAACAGA
GCCCACAAGA
AAAACGCTCC
AAGAATTGAG
CCAAAGATI'A
CTITAGACGA
TTAAAATI'GA
TCCGCCCAGC
TGACIATG
GTATTGAAAT
AATTGT=rA
ACCCTICAT
GCGGTAAGAG
ATCAACTCAA
TCCCTCAT
GCGTGGCTAA
TTGATTCTTA
TGGTGAT'GA
TCGCTAGAAIl
GCCCGAGCGI
TTAGGGTAGG.
TACTAGGAAC
ATCTAAAAAA
TTCATGGCTA
TAAAAAATAT
CCTITTATAC
TCTATTAGGC
CGGCAACAGC
GATAATGCTT
TTTTTACCCT
GCAGGCCTT
TTCTCAAAAA
TGATGAAAAC
CACGACCTI'A
TACCCATTAC
AAAAGAACCT
CACACTCAAA
AAACCACAAA
AAACCCACAA
AAGCTITAGC
CGAAAATAAA
TGAGCTTCCC
AAACGAGATI
TGGCGATATI
CCCTAGCGTI
CGCTGAATCC
CCCTAACAGC
AAAATCCAGC
CACGGATIP
CGTGGGCGTC
ATI'AGTGATC
ACTCACGCCC
AGAAATGGAC
*TAATGAACA;
*TGAATTAGCC
CGCTCAAATC
GGA.TGTCGT1 CACTAAGAI
GGGCGATATC
CTITATFI'AG
GGTAATAGCG
TTTGGGTATC
AGGGCTAAAA
ATTTTATCF]T
GCGCGTFI'GT
ATGGTAG'ITA
TATATGAACA
AGCCCTAAT'
AAAGAAACCA
CACAACACCC
AATAATTCAG
ACCATTTACC
AAGCAAGAAA
CCTATCATGC
ACCCCTAACC
AAAGAAAATA
CCACTAACCC
GAGATATTAG
ACAACGCAAT
GACCAAAAAA
ATACGCACTT
AAGGTGAGCC
ATCCGCAT'C
CAAAGCCAAA
TCGCCTCTAA
AAAAAGCTCC
AATGCGATGA
ATCGATCCCA
AT1'ATCACTG
CGCCGATACT
SGCCCAAAGTA
GATI'TGATGA
GGGCGAGCGA
k ACCGGCTTGA r' GATTCTAAAG
'CTCTTTACCC
CTTTAATCAT
GT ITAGTGGG
TTTCATTGAT
ACCCITTTTAC
TACTCT1IT'
TITTACACCC
TCTCTTATIT
AAACACAAAG
T1AGCCTGAA
ACAACGACAA
CTAACGAAGA
AGCCGCAAGA
CTAAAAGAAA
CCAAAGAAAG
CCATATCCGC
ACCCCATAAA
TAGAAGAAAA
TCACCAGCGC
ACGGGTTGGA
TATTGAATGC
TCCAGGATI'
ATI'CAGGCCC
GTATITTAGG
AAGCCCCTAT
TrA'TI'ATTT
CCCTAGCTT
CCCACTTGCT
TITI'ATCCT'
AAATGGTGGA
ACCCTAAAAA
CTAATGAG
ACGGCGTIGA
I TGACAGGGGG
.GCGGCTTGCA
*TTAAAACCAA
TGATTTTAGA
CCCCAGGAAC
AGGGGTITTA
GCGTITTGGG
TAATTT1ACC C
AGAAATCGT
GCAATCTAGC
TTTTATAGGG
AATTTTATTC
CCTTTI'AAA.A
AAAAGAGGGT
AGAAAAAGAA
ATCGTTITTTA
AGGCTTAGTC
CCGAITTGAT
AGAACCCACG
ATCCAACACA
AGAAGATGAT
TATAGAAGAA
TAAAAAACCC
TTATGGCGAA
GGTTTGCTTG
ATI'GAGCAAG
TATTGTAACC
CTTGAGCGAT
CAAAGGTAAA
AAGAGAAAT'
AGGCAAAGAC
CATCGCCGGC
ACITTATAAA
AF1'TAGCATT
AGCTATCGGG
CGAATACAAG
AGCGTITCCCC
CAAAGAAGCG
CCTCATTGTG
CTIGCCT1'CA
CACCGATGGG
AAACGGGI'A
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1800 1860 1920 1980 2040 2100 2160 2220
GTGCGCTTGC
AAAGCCCAAA
TTAGACACCC
GAAAAAAAGA
GCCCCACCA
GGCAACAGAG
ATGCCCCCT
AAGAGGTGGA
CTAACTATCA
TCACTTCTAC
TTACTGACGA
AGArTI'GCA.
TGCCACTGAA
ATACGATAAA
AGGCGATGAC
GAGCTTTTTA
ATTAGAAGCT
AAATT
GATGAAATCA
GATTTCTTGC
ATTCTAGAAA
CAACGCCAAT
CAAGGCTTTC
AAAAAATCGT
TAGAAGAATC
GGGCTAAAGC
TAAAATCGG
TATCCCCAAG
GGATTTTATT
GCGCATGCCT
GGTGATTI'A
CTACAACCAA
AAACGCCAAA
2280 2340 2400 2460 2520 2547 INFORMATION FOR SEQ ID NO:1069: SEQUENCE CHARACTERISTICS: LENGTH: 1344 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAfrE/KEY: misc-feature LOCATION .1344 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1069 s**
AATTACCTAA
AAAAAACCCT
'TITTACGCTT
CCTACTCTAG
F1'GGGGAGT'
TATI'CCATI!A
ATCGTAGGGG
GTGGGAGGAG
AAAGGTTT
TITI'CGCTCT
CGTTATTTAT
ATGGAAGAAA
AAAGAAACCC
AAAGCCTTAA
ACGGTGTATT
TITATCATGC
GCGGATAAAA
ACGCCTATTG
GAAATACTCG
GAATTATI'CC
GCGCT1ITTG GAGGGGT1'TG
TTCCCTAA.AA
AAATITCATG TTCAA TAAAATCCCT TrAG ATGCGTTCCT TGCTC CGCTCATCTC AC TG'TTI'TGG TA~ TCCITATGGC GCTAG AATGGGCGT1' CTTG' AATATGGCGT GGTCG ATGGCTC'TI' CCA' TI'ATCGTTGA AAACG TCGCTITAGA GT CTATGGATAA TGAAG ATATCAAAGA AACCC TGATAGTCTT TGGGC TAAAAATC'IT TTTAP T1TTAGCGCT CTC? TCAAACGCAC CCAAJ TCTITTATGG TATC.
CATTGAGCAG CATG; CTGAACATGT GCGAC
GAGGGAGCGCGGJ
TGGGCTATGT CATGJ AAACCTAT'I GGAG
GGATA
CCGCT
CTI'AT
T TTA
TGGGG
GCTCT
TITA
CCACT
'ATGTA
'TrTAC 6TATTA
~CGACT
:AAAGA
:TAACT
LCCAAC
7A'TTC
LTCTG
LaGCAT
G'TT
;CGCTr 7'ATATA 7TGAGT GCCATGAACC CCCAGATTICA AGTI'CAGGCA A TI'TAGTGGA 'ITCGCTAAGG AATITACCCA GTITI'TATGC TAGGG riT GATAAAAAGG GGCGTAAAAC TTCATGCTCG CATI'GCTCCC ITG'ITAGCCA GGCTTTACA TATCTCTCTG. AAITAGGCAA.
AC TFI'AGTGG GAGGGCAACT ACGCATGAGC AAATCAGCGC GCCCTACTCT CGCTCIT7-17 CCTCAAAAAA AGACTAATGT GGCAGTI'AA AGGAATrGCT ATGGGAGGGA G ITTGCTI' AGCTCATCGT TTAGCCCTAA ATC7I'CTTAC AACCCTTATG ATGG'TTIG CGATCACAGG GCCACTAGCG TGTATGAAGC TACACTIGCA 'FIGCTG GGT GGCGTGGGTT TAGCCTATGC GCGFIAGAGT TCAAACAGCA ATTGTTATCT TTATGGTTAT
ACCCCCACT
ATGGTATGAT
CACCAATGAC
CATGCGCCCT
TTCCATGGTG,
CACTAAAGAA
GGGC'TI'AGC
GAATGGTAAA
CTTAGCTATT
GTTTGC'FrGG
GAGAAATATC
AAATAATACA
CAACCATAAA
TTACACT'TT
AGAAAGCAGT
CGGGATGCTT
GCT1'ATIGTA
CCTATITTAT
TATI'AAGGCG
GATCGCCAAT
TGGTTTTGAA
GGTTATCATA
120 180 240 300 360 420 480 540 600 660 720 '780 840 900 960 1020 1080 1140 1200 1260 1320 1344 INFORMATION FOR SEQ ID NO:1070: SEQUENCE CHARACTERISTICS: LENGTH: 1938 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1 .1938 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1070 a.
a a
AAATGGAAAA
AACACGCTTC
GTGTGTTIAG
ACCAACCCTA
TTAGTGTATA
TTCAGGCAAT
GAAATCACCA
AGCCAATACG
TGTGGGGATG
CTTCGCCTTG
ATTAATATI'A
CTAGAATGCG
TCCCATAAAC
GAGGGGAGTG
GAAAACGCTC
TTTGAAGAAG
CCTAAAACAA
CCCGCC1'TTA
GCTATCGCTA
AACACGCAT
AGGGAGCATG
TITIGCGCGA
TTAATGAAAT
GGGGCGACGC
GrCTTTCAGGC
AACGCCCCTA
AAAGAGCAGG
CTI'GT1GCGA
GAAAATATTC
GAAAGCTATT
ATAGAGTGGT
AAGGGCGATA
AAAAGGTTAC
ATI'TGATGCA
GCTI'TTTGTG
GGCTAGCTGA
AATGGCTCAA
GTTTGTTGCA
TACACTCTAA
CAGCGCCTFI'
CTCAAACCCT
GGGATTTGCA
ATAATCTCAT
GTTTTAGCGA
ATGGGCATGA
CCACGCTTTT
AAAAAACGCA
AAATCAATCC
TGAAAGTTAG
AAGAAAAGAT
AAAAAGGCGA
AAGAATGCGA
TGAAACACTC
CCATGGGGGC
CCTTTTITGT
TAAAAGCCCT
ACCAGCCCAT
CTAGCGATGC
GCGCTCTTAT
ETCTAAAAGG
GCGGGAGCGA
CCACTCAAGT
TTAAAGAACT
ATCGTTI'GC
AACTCTTTGA
TCAACGCA
A'ITGAGTAAC
TGCGGACATG
TGTGATGGTG
TAGGGACAGG
TTTGTGGGGC
AACCCCAGGA
AGGGCAAGGT
TTIAGATAAA
AGAAGGCATT
TGTGATTTAT
ACAGGTI'AAA
CTATCAAGCG
AATCGCTCAT
TGGCTCGCCT
TAACGAAAGC
GGGTA ITAGT
CCATGCGTTA
ATCTCTAGCC
GGGCTI'TA
TGGCGATI'TC
TATCACTAAC
GTI'TAGCGAT
TITATCITC
AGAGCAATIG
TTTI'GAAAAT
TTI'ATCGCGC
GGCGTATGTT
AGTCTCTTA
AGTGAGCGCG
CTTTAAGGGT
GGATAAAATC
AAAAITTTGGC
GCTGATTTAG
ATAGATAAGG
GTTAAGCT
TTGGTTIA
TTTrGATTTGA
CACCCTGAAT
TITGCTAACG
GAGGCGATT
AGFI'ATGAGA
GACAGCAACC
ACACGCTT
ATI'CATAACG
ACGATCATG
TITAAGTAAAG
TITATAATTA
TTAGAAGCCT
AAGAATTTG
ACGAGAGTGA
GGAGGGAGTG
CCTITAGGGC
GCTTTAGCGG'
TATITTAATGC
ACGCATGACA
AGCCATTTAC
AAGGCT1'GCA
CAGAATTTGT
AAACACCACT
GCTITAGAGA
CCATGCTTTG
AAAGTCTTAG
ATTGGCATGG
TTTAGCGI'G
AACGATTAAA
CTAATAGCGG
TGCACCTCAA
GCGGAGGGCA
GITTAGACGA
TACACCACAC
CTGTAGGCT
CTCATAAAGT
GCACTI'CTTT
AGATCAGCAT
TAGCGCAAAA
CTTTAGAAGA
GTAAGGGGGC
AAGTGTTIGAA
GCCCAAAA7A
TATGGGAAAA
ATTITAACGC
GTAACGGCAT
CGGATTTAGC
AAAACCTGCA
CGTATGGCT
CTAGCATTCG
GCATI'GGGGT
GAGCCTIGCC
TGCAAGTGGC
CCGTGCTI'GA
CTAAAGATCC
GCGCTAAGAT
ACTTGT1'GGT
TGATTGAAGC
ATI'CTIrTGG
AAAACATTAC
AAGCATGGCG
GCATCCAGGC
CCTAAACCCC
TGCGAGCGCG
TTTAAAGCGT
CGAAGGCATT
TAGCATGGCG
CTATTGCTTG
AGCCGGGCAC
TGAAGGCGCT
WTGGGAAGTG
AGCCAAAAAA
TATIGGCTIA
ACAATCCAAA
CAAAATGCAT
GTCCTI'AAGC
CATTAAT"AC
GATTAAAC
CCCATCCAAT
TTTrGGGATC
GTTTGTGCCT
ITTGAGCGCT
GGGCGAAGAC
GCATITTCTAT
ATI'AAGTITG
TGAGGTTTCT
CATTATCACG
'ITTAGAGCGA
AGAGCAAGAT
GAGCCGCGCG
GAGCTCAGCA
CGCTCAAGCG
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1800 1860 1920 1938 S00., 0* 0 INFORMATION FOR SEQ ID NO:1071: SEQUENCE CHARACTERISTICS: LENGTH: Bl9Thase pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .819 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1071
AAGGXITATT
AACCGCTIGG
GACGATGCGA
TTAGAAGATC
ATTCTATCAG
CTAGATIT1'G
GCTITATACCA
GGTTTTAAGG
AACGCTGAAA
ATTCAAGCGG
GGGCAAAACC
TTAAGGCAAT
ATTGAAATCA
ATGAACGCTG
GCATGCAAAA
AITTAACCTC
TTACAGGCGA
AAACCAAAGC
AAATCTATAC
CCCTAACAAG
AAGACGGGCA
TGCTTTCACG
TTGAAGTGGA
GCGCGTITGGC
TTTATACCTA
CCATGCTAGA
ACCGCITTI
AAGCGATIAA
TGGGTATTAT
TAACAATTTA
TTT1TTAAGG
GAGCGCGAAG
GGATAGGAGT
CCCTAACCTC
TITCAGCGTT
CTCCGGTI'TG
TCAAAATGGT
TITAGTGAGT
TCAGGGCGAA
AAAAAGCAAT
GGACATGTAT
CAAACTCGCT
GCGGCCACAG
GCCAACCTAA
CTTACCAAG
TATCTCAACC
CITGGCGCGT
TATrrTGCGA
GATAAAGACG
AACGAAAAAG
GGAATCACTT
TTTAGCGAAC
GGCGTTCATC
GTCAATGCGG
TCTAAAGTGC
ACAAAAGCT
GGGCAATGGC
ACACCAACGG
AATACCGAGA
GCAACCTCAA
TTGAAGGGAC
TACAGACTAA
GCTI'TTGGT
GAGGGATCAT
TTAGGGATAA
CTAAAAATCT
AAGTCTCTGA
TGCGTGAGAT
TAAAAACCCA
TACACAATTT
CTTTAAAAGA
GCAACTGCCC
TCGTGTGCCT
GAATAACCCC
TGAGGGCGTC
AACCC LTAAT
GCTCATGCCT
TGAAGCCCAA
TAAAAAAATA
CTCTGGTGCG
GAGCACTTTG
TCAAGATGAC
120 180 240 300 360 420 480 540 600 660 720 780 819
C
INFORMATION FOR SEQ ID NO:1072: SEQUENCE CHARACTERISTICS: LENGTH: 1776 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1776 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1072 GGAATGATAG CGCTGAA TIT AAAAGCCCGC TAGATTCAAG CCTIATTI'GT AITATITTGG GAAAA TTAA AACGCTTGGT AATCTTGG AT~T TCCAC ITTGCAAIT ACAACATGAT GCAAGAATGT ATGA FTTAAA ATAGAAATCA ACCAGCA TI' GACGCTAAAG ACGCACTCAT AAAAGCCCTA G TI'AGTGGA GTTrCAACCG GGCCTAG TTT GCAACGCTIT 1'ITGCATAGA GATAITGTIGC TGTCTITAGA 'FrAGAT =C AAGAAGGCGT CAAGCGATI'C AAAAAGGGGT TFTGATTTGC ACCAGTATGG GAAT1'AGTGG TGCATTCTCG TCACAAAGCG GTAACAGCCA AAAAAGGATA AAGACAAGAT
CAACCTCTTA
CTTAGAGCTA
C TTGGGTAAT
GGTCATTGAG
TGAGATTTTA
TGCTTCXI'TA
ACTr'I'TTTAAC
CACGCGCGCT
AGGCATCAAA
TICITGTGAAC
AAATAAGCAA
CGCTTCTTTC
AAGGGTGGAT
TAITIITTGCT
TAAGCAATTC
TTATGTGGGC
,1C1AAAAGG
CGCTAGTGGG
ITTTATAGAA
GATAAAGAAA
TATAAAAATA
GGGGTGTIT1
CCTGAAATAG
GAAAATCGrI2
TI'GATATGG
GCTTATTATO
TTAGAGCATG
CAGCATGTCG
GCTTTAAAAA
CTCCCCCTTT
CCTATTCTAG
TTAACGGCGA
CTGACTI'CCA
AGIT1'CCGCC
ATAGGCATGA
TGCGTGTTTA
GCGATTTATG
AAATACGGGG
CAAACACGCC
GCGAAATTCA
ATCGCFI'GCT
AGGTGArrl' TGATTTrAIT
ATAAAA.AGTC
AACGATACTC
GCGCTATTAG
CTAATTTGCC
ACAGAGACAC
TAAAAGAAAT
CCAGAGCCGG
AATTCTATGA
TTGTGCATAA
CC'TrGGCTA
GCGCAGCGAA
TCGGGCA.AGA
GCGATAGAGA
GTAATGGGAA
CTI'ATTTGAA
CATGCTCTAT
TTTAGGCAAT
CATI'GTGCTG
GCATGCAAGT
TCGITIATAC
TCATCAAATG
CGTAGGCAAT
TGAAGTCATC
CGCTATTATC
CGCTCCFI'AC
TATCAAGCCT
AGAAACCCCC
ACGATTGATT
TACCAACCIT
CATGGCGTAT
TI'TGAGCTT T
GATCAAGCCT
AGTAGAAACC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140
ACTI'TAGTGT
AAATTAGAAG
CCCTITAAAG
XFI'TATCCCA
GAGATCATCA
GCAGAGTTTT
TTTGAAGAAT
AAACGATTCA
CATATCGCTG
TTAGAATACA
GTGATAGAAG
GGAAACTIT
TcATI'AACGC
AAGTGTGCGA
CCCAATCAGA
AATACGCCAA
TAGAAAAAGT
TAGAAAATTT
ATTCGTATIT
AAATCGTGTG
TTTACGCGCA
CGATCAAAAT
CTTAGAXIT1'
TACTGAGGGG
AAAAATAGAC
ACAGGCTAAA
TGAGAAAAAA
GGAAAAGCTT
GAGCGCTGAA
TATGGATGCG
TAAAAAAACG
CAAATACTGG
GGCTITGAAA
TTGAAiAAG
GGGGCTAGGA
AAATCCAAGC
AATTTAAAGA
ACGCAAGTTG
CATGAAAAAA
ATTGATAACG
ATACAATCT'
AGTAATGAAG
CTTFI'TAGTT
GAATGG
ATATTTTTAA
TTAAAGGGAC
CAAAGCCTCC
TCGCCAAGAA
AAGAAGCGTT
ACAAATTAGA
TTAAAGAGCT
ACATT'ITCCA
ACGGATTAAG
TAGCGGGTGG
cACGcccTAT
TAAAGAAATG
TATcAATCT
AAAATGCGAA
TTAAAGGTG
AGAGTTIGGAT
rTL1GATGAC
CCAGGAATTG
GGCTAAGCAA
GATGGATTGC
1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1776 INFORMATION FOR SEQ ID NO:1073: SEQUENCE CHARACTERISTICS: LENGTH: 348 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .348 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1073 a. I a *1 a GTGCATT7TA
CAGGCGTGCA
ATCCCCCCTC
T1'GGGGCT'
ATTGGGGGCT
GCGCATTGCC
CGTGTATCTT
AAAAGCCACC
AAGTAFI'AAC
TGAGCAGCAC
TTGAGCATI'A
GAATTGAATG
TCTAACCCTA TrAAAATGGA TFIT1GCCAGC AACCAGATCC ATTCAAGGTC TGCAAAACAT CCCTCAAATC CAAGCGGGTA TACAAGGGGT TTTAGAAGCC CCCTTATTGT ?rI'CTAAGCA TTTATCCCCT TTATATGGGT GGGGCAAGAT CAAAAAGACG CCAATGAAGT GTATCGCT
CAAAAACAAG
CCAGCAAAAT
GATGCAAGGT
AAATGTGGTG
TCACGATGGT
INFORMATION FOR SEQ ID NO:1074: SEQUENCE CHARACTERISTICS: LENGTH: 1131 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1131 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1074 CGcATGAATT
GTI'TTATTGA
TTGAAAGACA
TCTAGGCAAT
CCCTCTATGC
ATTCCCTCTC
GCGAACGCCA
AACGCCTTAA
GGGACAGACG
AATTACGCGC
AGCATGTTI'A
TTAAGGCTGT
TATTTTGGGG
TTI'TTGAACA
TGGATCAAAA
TTTATGATGG
CAAATAGTGC
GAATTTATAG
ATAGGGTGCG
TTTI-rAAAAT
TCCTTATAGG
TCGTAACGCA
TAGccTTCAT
TGGAAGCCAA
ATTTTGAAGC
ATI'ACTI'IT
ACGATGAAAT
GGATTAAGAT
TCTCTAGCGT
CTAGCTCCAG
GCGCAAGACT
cGcTGTTFI'C
GCTI'GATTI'
ATGAAGCCCA
GTITTGTGTG
CTGCTTATCA
ATGTTTATAT
TGTTcAAACT :cTTTTAATG CGCTCcTTTA
GCAAAAAATC
GGTGCAAAGC
AAAGCTTITA
cAATATTTAT
GATTTATGGT
CAGGTTCAAA
TAAGCCTATC
GTTTA'Tl'C
GCGTTTGGAA
CTI'GGTGTTC
TTTTTATGGG
CATGCTITGCG
CACCACTCAA
GCCTTFI'GAA
TGGGATCAGT
CCATTTTTAC
CAGCTCTTTA
GAGTTAAGAG
ATCTATGGCT
GCCCTTGTAG
TCCAACGAGT
AAAGAAGAAA
AAACAAGTGC
GCGTI'AGCGA
CGCAACCCCC
GCTTTGTATA
ATCTTACACC
TTGGCCCTT
ATGGGGGCGT
ATCGAACGGC
GCCTI'GAGTT
ATCGTITTGA
TCCTTGCCCT
TTGCTCGGGC
GCGCTTATTG
AAGAA.AGCTT
.CATTGTTTC
1GTTATACCC
ATGAAGACAA
TAGAAATCGC
A.AATTTATGG
CTGTAACGAT
ATGCGGTGGT
AAATAGAAGA
ACCCTAGTGA
AGGTGATGCT
TAGACAAGAA
?ITAGCGTI'T
ATGGAAGCGC
TGGGGTCGTT
TTTCTTCTIT
CTTATTTGCA
GATTGAATCA
CGATT1'TTAT
GTGAAAACGC
TCATAAGGGC
'TrTGCCTTAT
TTCCTTCCTT
'ITTCTTTAGC
GATCT1'ACAC
AGATTITTAT
GGGGAGCATC
AGcTGAATTA
GGGGTATFI'G
cATI'GCAAGC
ACAAATCGCT
TGTTTTATGG
TTTAATGGTG
TTTAGGGGCA
GcCCrGATT
AGTCTTCGTT
TATGCATGCG
CGTGAGTTTT
T
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1131 *9 9 9 *ee9 99 9. 9* *9c* 9. 99 9 9 INFORMATION FOR SEQ ID NO:1075: SEQUENCE CHARACTERISTICS: LENGTH: 267 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genornic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylor~i (ix) FEATURE: NAME/KEY: misc-feature LOCATION .267 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1075 *9 99 .v 4
ACCTTAAAAG
TTGI
9
TGTCG
AAACAAGAGA
AGCCATCAAG
ACTAGCCT
GGATTGFT1
TGTGTTTTAT
CCCCAAGACA
TGGCGT'FIGA
CAGAAGCTAA
GTTCAGATTG ATAAGCGCAT GGGT TITACA ATI'CCcTFI TGTTTAGGGG TITTAGGCAC GCTCCCTATC GTGGTGGTGG ATTTGGATAA ATI'AGGCGCA ACGAGTGCGG T1'GAAATCAA
ACGCTTT
AGACAAGTTC
GCAAATCTT
GACCACTACA
ATACCAAGTG
INFORMATION FOR SEQ ID NO:1076: SEQUENCE CHARACTERISTICS: LENGTH: 231 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: mjsc..jeature LOCATION 1 .231 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1076 AGCATGAAAA AAACAACCCT CTTT1GTATTG GGCT1'ATIAT GTTGATGGGA TTTCTCAAAC CGAGCCITCT TCTTTGAATT TI'GAACCATT CTAACGCCCA AAAACTCTCT TTAAAAAACG AATCATGAAG GCI'GCATGC GCAGAATACG CCATTAAGCG
TCAATAGCTC
TGGCTGAAGA
CATGGAATAG
AGCGAGTAAA
TTTAAGCGCT
TAGCCTGCCT
GGTGTTGTCT
A
INFORMATION FOR SEQ ID NO:1077: SEQUENCE CHARACTERISTICS: LENGTH: 303 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .303 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1077 a.
a a a
GTAAGGAGAC
GTTTIAATGG
AAGTTTGAAA
ATTGAAGAGG
CAAGCTAAAA
AAA
AAACTATGAA
CAACCGATGT
AGAAJAGCTTT
ATCTTATGGC
AATI'AAGCGA
AAAGGT1'ATr
TAAGGCTCTT
AGGTAAAAGC
TITTAAAAGC
TGAAGACATC
GTGGCTr1'AG
GTAAAAGGT
AAAATCGTTA
GGTGCCAACA
AAAGCTI'TAG
GCGTTTGGC
GTGCCGCTI'G
ACATGATGAG
AGAATCCTGT
CCATATACAT
GTCGCAAAT
CCATGGGGTI'
CGAAAAAGAG
CATGACCGCG
CCCCACTCTC
a INFORMATION FOR SEQ ID NO:1078: SEQUENCE CHARACTERISTICS: LENGTH: 477 base pairs TYPE: nucleirc acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO jiv) ANTI-SENSE:'NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .477 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1078
AGACCTATGC
TACCCTAACA
TTCCCCCAAG
CTAGAAGAAA
TATGATICC
TATTTTTTAG
TTTAGATCCT
CGCCAAGTGT
TACATAAAAA
CATGCGAAGT
GAGGCATTGA
TTGGCACGAA
CAAGCAACAT
TGCGCCTAAA
ATCAATTCAT
ACCGCCAAGT
ATATCGTCCT
TITI'ATCGCT
TGAGGGAGAG
TGAAATAGAG
GGAGCATAAA
GCATGTTAAC
CCAGCTTAAG
CATCGCTTAT
AATGTrGCGG
GAGCGCATAG
ACCCCTTTAG
ATTTTGGCGC
TTCTATTCGT
AACAITGATr
GATITGCTTA
TTTAGAAAAG
CCAITATCAT
ACATTGAAGG
AAGCACTCTA
AATACCCTAG
?I'GACGGGCA
TGAACAAACA
AAAAAATCGT
AGGGGTATT
GTCGCCAGAC
GGCGTGGCAG
TAGAGAATTA
ATGGATCGCC
AAAGCAGCGT
CACGCCAGAA
TCCCTI'CAAA
GGGGTGT
120 180 240 300 360 420 477 INFORMATION FOR SEQ ID NO:1079: SEQUENCE CHARACTERISTICS: LENGTH: 393 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .393 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1079
S.
S.
TGCATGAATC
TATTTTGTGG
ACTTTTAGCG
AAAAAAGTIT
ACGACCrF
GAAGCCATIT
TGG'TTIGG
TTG3TCTIF=
GCAAAATGAT
TGAATCTCAT
TTGGTGATGA
CTICTTATGG
CTITATGTCTT
CTAAGAATTI'
GTGGGCCGCT
GCCCAGTAAA
AGGGTG1IT TI'rrGGGATr
GTTAGACACT
AGGCACTAAC
TGTAGGCGTr
CTAGGAGGGG
TITI'TAATGT
ATCATCGGCT
TI'CI'TGTAA
TTAAAACTCT
CTTTI'AGGGC
AAT
CTATAGGGAG
TTGAAAGTTI'
TTATGGGGCA
CCGGAGITIT-1
TGCAAAAATC
TI'ATTGGGGT
CTCGTTAAGG
CCCTITAGGG
TTTGGCCGCT
AGGGGGTTT
CCAATACC'FI
AGCTATCGGT
120 180 240 300 360 393
S
a.
a a INFORMATION FOR SEQ ID NO:1080: SEQUENCE CHARACTERISTICS: LENGTH: 819 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 819 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1080
TATI'TATCAA
AAAAGCCAAA
GGGGCAAA.AG
TTTGGGCATG
GCTGAAAGAA
TCTGGCTCTA
GAGTGGGGAG
GGCCTTTTAA
AAGAGCATT
AGGATCTGCC
GAGGTAGAGC
GATGAGCTTTI
TGTTCCACTT
AAAAACCCTA
TCGTGGTGGA
GCTCTGTGAT
CGATTGAGGG
CGTTAAGCGG
AAGCGTTTGA
TTAAAGCCGA
AAAAAGCT'A
ACCCTGATGT
ACCCTAT'GA
CCAGTAAAGA
GTTTGAAAGA
TAAAAGAGTC
TATGCCCTTI
AAGGCGAAAA
AGATCAGAAA
CATTGAAGAC
GCTTI'TAAAA
GAATrTGCAC
AAATFI'AGTT
ACATOCCACA
TAAGATCCAC.
GATCATCACA
AGAGCATTTG
TTATCCTTA
AAGGGTAAGT
TGAATACTI'A
AGGGATTGAT
GATCTGC 1TC
GGCATTTTCC
GTGTGCI'CA
AAACATGGCT
TTTGTCGTTA
TCTGAGATGT
GGCAGGATGG
AAACAAATCA
AACGATAAAG
GACATGTGCA
ACGCCACGAC
CATGGTCATG
GCGCATGCCA
ACCGGGAGTA
AAAGATTCT
CTATCGCAGC
GCAAAGAGGA
TTAAGGATAA
CGCCGATTCT
TTI'TAATGGT
TAGCCCCTTT
AGGAATTGTI'
AAATCCACAC
TGGAATGTGG
AACGCATCGT
ATGAAGATCA
CTTGCGCGGT
TCGCTTTAA.A
GTCAAAAAGA
TTITGTAGAA
TGGCATTATI'
AGAAAATGAA
GAGCAAAAGC
TGTGGAAA.TG
TGATCCTAAT
TAAAAATTTA
G 1IT TTGAA
CATCCACAGA
GGTFI'TACTA
GTGCCATATG
TCATTATCAA
120 180 240 300 360 420 480 540 600 660 720 780 819 INFORMATION FOR SEQ ID NO:1081: SEQUENCE CHARACTERISTICS: LENGTH: 723 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .723 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1081 0 4 *4 4 4 44* S
CGATTTTTAC
TTGACTAAAA
CAGCAATITTA
TI'AGCCGGAT
ATAGAGACTA
ACGCC ETTAA
GCCCTAAATI'
AAAGGCATGA
CFTITTGATG,
ATCGCTAAGG
GTGGAAAAGT
GATGTGGGGG
AAA
AAAAGAGTGC
C'FTATGGGAG
TAGGGCTrT
TGAATTTGAA
AAAAAAGCGT
AAGCGATCGC
TG'FrAAAACG GGGAAAAAT1'
AGCCGGTGGC
AGTTI'AGCCA
ATrI'AGACAG
AATAAAAAA
GCAAATTTGG
TTAAAAGCG
AGGGCCTAAT
CTATCAAGGG
GGCGTFITA
TITrATAAG
CTTCAGCGTG
GCAGCTGATT
TGGGATI'GAC
AAACGCAAGC
CGCGATFFT
AGGGTATAGC
GGAATTAAAA
CTAGACAATA
GGGGCGGGTA
GAAGTGAAAA
AGCGATGGCG
GA TTTFITA
CCTI'TAAAAA
?I'AACCCTAT
CCTATI'GCAA
TI'GCTAGTCT
TITAAAAGAAG
AGTTTGGAGG
AAACCACTCT
TI'TTAAACCA
ATITTAGA
GCGATTITGA
GAGAGTTCAA
CACGAAACGC
GAGAAGAGAT
CTACGCATT
CTAAAGTGGT
CAGCGTATAA
GTTAAAAATT
AAAGATTGGT
TCCTAAATI'A
TGAATCAAAA
AGCCCTITCA
T1'CTTTGTAT TTrI'GAGTTA
GGTGGTGGAT
GGCTI'TTGGG
AGAA~AGGTTG
TGCTAGTAGA AATAGAGAAT TCAGTI'TGAA ACTACCCAAA INFOR~MATION FOR. SEQ ID NO:1082: SEQUENCE CHARACTERISTICS: LENGTH: 864 base pairs TYPE: nucleic acid 790 STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NPAdEIKEY: misc-feature LOCATION .864 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1082
AAATCGTGGT
GGGCATGGCA
TTGTATTTGG
CGATT1'GACA
GACAATGTGA
GCGGATAAGG
GTTTATAGGG
AAATATGAGA
GCGGATATTG
TGCAGCATTG
AAATCGCATT
TTGCCCTATA
TTTGGCACTT
AACTCATGGG
TTITGAAGCGC
TT ITICTATGC
TGAAGAAAAA
CGGTCT1TTTT
AACAAAACCA
TAACCGCCTC
TGCGTTATGA
GCGAGGGCT'
TCATTITCCC
CTAGCGGGAA
ACAACCCCAT
TGTCAATGTG
TTI'TCATGTC
CCCACTI'AGA
ATATGACCT
GCTACATCAA
CCCTTTTTAT
AGCAAAAGTC
TITGTTGAGC
TAAGATTT
AGGGAATGCG
CACCAAGACT
GCTCGTTAAA
CTTTTATGTC
GGATCAAAAA
T1'GGCATGTC GAATCCTAAiG
CACGAGCAAT
CGGCT'ITATT
TACCCCACAA
CCCT
GGTTTGTGGT
TTTTGGTGTT
GTATCAGACG
GAAATCCTTG
ATCCTATTGA
AAAGAAGCGT
ACCGATTATG
CAAGACAGCG
TATAAGATTA
AATGCGACTT
XITTATGTCG
AAAAGAACTA
TATTGCAAC
ATCCGTTACA
GTTTAAAAAC
GTTTrAAAAT
CTAAAGAAAT
CGGATAAAGT
ATTATGACGT
TATTAGAAGG
TGAAATTGAG
TGAGCGGGAT
AAAACATGAG
CAGGCTCATT
GCGATATTCC
CCGGGTI FrT
CCTTTTATTT
AAAGGGGTTT
CCCTATCATA
GATITCGTTGG
CGCTATGCAA
GAGCGCCAA.A
GTATATTCTA
CAATATTAAG
TITGAACGAA
TTGGGTGAGC
CGCTTCAGGG
TAACATGCAA
TGTATTGTAT
ATACCCTGAG
AGCCCCCAAA
TGGCTTGAAT
0 0 .0.
0 INFORMATION FOR SEQ ID NO-1083: SEQUENCE CHARACTERISTICS: LENGTH: 447 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAM~E/KEY: misc-feature LOCATION .447 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1083
ATCGTTAGAA
TCTGTGATGG
TTTATGATCA
ATCTATCTTG
TTTATTTGGG
TTGTTGTTGA
AAAAAAGAAA
AGAAGTTAAT
CTCAATCCT
ATCTTTACAC
TCAT GCCAGC
CGATGCAACA
TGCTCAT'GC
GGATGAAAGC
GTTAGAGATG
GCTI'GTCCAT
CCTTTAAA
GATTTATATr
ATTTGAATTT
AGAAATCAAA
CTATATCAAA
AG'FITGCAAG
GCCTrTI'TG
GAAAAGAATT
CTTAAGCA
TCTTI'TAGCG
CGCCATAAAA
AAAGCTAAAA
CATTAAATAC
CCGCCTTGCT
TCATCCATT
TCGCTCTTr
CTGTI'GTCAT
GCGTGAAATr
TCCTGTATTT
ACAAGATTCT
CGCCCTAGCC
GAACCGGAAA
GAGTGGGGTI'
GCTITTGGGG
CGCTATCACT
TrI'AGAAACG ATI'CTTATCA TCGTGTI'AAT GGGCATT 447 INFORMATION FOR SEQ ID NO:1084: SEQUENCE CHARACTERISTICS: LENGTH: 357 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION l. 357 (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1084
CCAGAAGGAG
TCCTTI'GTGA
ACGGCTAATG
CTCAACCCTC
GATCGCTCTA
GATAT'ITTCA
GGAATGAACT
TTTTAGGGTG
AAAAGATI'G
ATATCGGC-TA
TCTATGATAT
AGCCAGAAAA
CAATGTGTTT GAGCCGGTTA CGCGATTGAAAC TTI'AACGA CCACGA'FTAT GTTTTTAACA TGAAAAATCC GCTATGATCG CGCTITAGAA AAGAAAATCT CATGCTAAGC CCTCACGCT TCGCI1TACAA CTAAAkTGCGT
GCATTGGCAT
CCAAAGAAGC
TAACCAAAGA
TCAAAAAGCA
GCTTFI'ICCAT
GGAAGGCATC
TGTTACCGCG
CTTAAAAAGC
GCAACTGGAC
TAAAGAC
INFORMATION FOR SEQ ID NO:1085: SEQUENCE CHARACTERISTICS: LENGTH: 705 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .705 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1085
AAAAGGCTTA
GCTAGAATGC
ATCTTITAT
TTGAATGAT!
GCGTTAGTGT
TTTGCGTCTA
CATGTCGTT
CTCACT'1TA
TGGTTTGT
TFITA.ATCAA
ACAATGGCGG
ACGCTCAT'C
ATTTCTAT
T'I-I-FTACAC
TAGAAGAATT
TGCTTTTATT
TCTATCCAT
TCTTGGCCCT
GAGTATTGTG
TCAAGGC'I'
TITTTTGGATC
CCC'TTAGTG
TGGCTCTATC
CTTAGCGGTT
TTTAAAAAA
ATCCTTTTGA
AA'ITA ITGCC
TTGCCGGTG
GTAATCTFI'
GTCTCTAT'
CTTTITCTA
TTAACGCCCC
GCTITAATGA
G'TIGGCGTT
AAACTTTATT
TGTTCGCATG
TGAGTITAGT
TGCACCAAMA
TTAAATATT
TTATTTCAT
TTTTTAAGC
TTTTGGAGCT
ACCGCAATCT
GGTrTTTAAA
CATCAATATT
ATATTATCCC
rrTAAA.ATCG TCcCCTTATA GGGGTCF1'TG GGGTCTTTT TTCTATAGTC CCGCATTTCC AG TTT GGATA TAGCCAGCAT GAT TTT CAAC CATCAAAGCT CACCGATTGA AGCATI'ATCG TTTI-FCGTTT TTTTGCTATC TTTAAT"FTTT TTGCCACCTI' GTTGCAAACC CTAATGTTAA TCTT TT CAA AAACACCATG ATCAAAAFT ACTCAAACAG TTT TFI'CCFT GA'FTCCTTT
CGCAC
540 600 660 705 INFORMATION FOR SEQ ID NO:1086: SEQUENCE CHARACTERISTICS: LENGTH: 831 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FE-ATURE- NAME/KEY: misc-feature LOCATION .831 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1086 a. a.
a
GAATGTAAAG
TIAAGCTCTI'
GGACAAGCCC
GGTTGCCCCC
CACTCCAAAT
TTCTI'CCAAT
cTTTTTGAT'
TTGGATATGG
AACGCTI'CTT
GCAGCAAACT
ACT1'ATTGTA
TGGTTGAAT
AGAGTGCCGC
TACCATTTGA
GAATGGAATT
CGTIGTTAGC
GTTrGAATAG
CAGGTCTTAC
ACGCTAATGG
TCAAGTCGCT
ACGGGCATGC
TCTCITGGGG
TrGGTATT
ATTGGAAAGA
ACCCTAATGC
TrGGGGTGAG,
TACTCATCAA
AACGGGATTA
TATGAAAAAG
CGAAGGTGAT
CAATATrI'AT
CGCTAATAAG
GGCT?1'GAAT
AGATATGACA
CGATTTAGGT
TGTGGGGAGC
TGGTGGGGTC
GCAANTCATT
CCCTTATAGC
AGCCAATATC
TAAATTTTTG
F1'CGCTT1'AT
TTGTAGCTT
GGTGTTTATA
AATACAGGGG
CATAATCCAG
GGTTTTGGGT
AGCAAGTGGT
AAACAAGTTT
GATITGTTAG
GCTATCGGCG
GAAGCCAAAG
ACCAACACI'
TACAAGCATA
AGCGCGGGTC
TI'GGGGTATA
TAGGGCTI'CT
TAGGGACTAA
ATTGCACAGG
GAGGCACCAA
TGAATGTGGG
TI'GGTTFI'AG
ATGCACCTAA
CTGATATTAT
GTAACACTTG
GTCCTGATGT
CAACCGTCGC
ATGGCGTGGA
CTAACGCTAC
ACTACACTT
ATCCGCGGTT
TTATCAGCTT
GAGTG'ITGTA
TATCAAI'TGG
TTATAAGAAA
AGT1GTATGGG
TAAAATCCAG
TGATAAAGAC
GAAAAGCTCT
TTGTACCCCT
TTITCAAGTG
ATTI'GGCGTG
TAACCTI'AT
T
120 180 240 300 360 420 480 540 600 660 720 780 831 INFORMATION FOR SEQ ID NO:1087: SEQUENCE CHARACTERISTICS: LENGTH: 2028 base pairs TYPE: nucleic acid STRANDEONESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FE-ATURE: NAME/KEY: misc-feature LOCATION 1 .2028 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1087
GCTTTTGAAG
AGTIGTGG
ACGCCTTTAA
CAAATGTTTG
TTGAACAAAG
TTTAAAAACA
TTTAAAGAGC
GGGCATCGCT
TTTTAACTA
TATCITAACG
GTGTTTTI'
ATI'AGCGGAG
GGGGTTTTGT
CTCATCAACA
GATAAAGAGA
CATGGGGGTG
ACCGCCTTGT
GAAAAGCATT
CAAATCCCCT
CTGATFFAC
CAAAGCTTGA
GATCAAGCCC
GATGAAATCA
AGCCGTITCA
ATTAAAATAG
GCTAAATACA
TTGAACATGA
AAGTTAAAAA
ACTTTAAGTG
ACAGGCAAAA
AATCACCTTT
GAGCATAAFI'
GGGGATAAGG
GAAAAAACCC
AATI'AGAGCC
GTTI'AGGGAC
ATCAAGGAGC
AAGGCTTTI'G
AGCAGCAAGA
GCCCCTTGAA
AAAAGGATTT
TGAAAGCCTC
AGCCCATTGA
AGCAAGAAIA
TATACGATGT
GGGAGAGCCA
ATGTFI'AGA
CCCTTAGGAA
CGATTAAGCA
AAGTGGTT
ATCTCAACGG
TTT1'AGAAAT
TAAAACAATT
AAACCC I"I"IT
ATGGGGTGGA
CCATAGGCAA
GGATITATT
GC'ITAATGT
AAATGCACTT
ACCCCCAAAC
GCGTGGAAGA
CGCTTATAGA
GGGGGGAGGC
CCCTTTATAT
TACAAGTCT
TAGACATCAT
GCGGGAAAGT
AAAGCTATAC
TTTGAGTTTT
AAAATTAGC
GATTAAAGTG
CACT1'ATAAT
CGCTCTTTTG
ACGCCCCTGG
GAGCGATTAC
AAGTTTGAGC
AGAAGTCTAT
AAAGATCGCT
GGGGCTAGGG
AAGGATACGA
CGAGCCTAGC
TITTACAAAAA
TGCGGATTTT
TAGCGGGAGC
CACTAAAAAG
TAAAAATGTC
GGTGTGCATT
ACCCACCGCT
GATTGTAGGG
AACCCCACGA
TGCCGAGCAA
TAAAGGAGGG
T TTGCCTGAT
'ITTAGAAATC
AGCTTATGAA
TGTGGGCTTA
TCAAAGGATC
TIAGATGAG
GCATTCTTTG
CAAAAACGCT
CA ITGCGAGC
GGGAAAATIT
TCCTTCAATT
TTAGATATTA
ATTITTGGGT
GGCATIGACA
TATGGGAATG
AAAGGCATTA
ATGAGCGAAA
GTCCAAGTCG
CATTTTTA
GAACCCATIT
TATTTGACTT
ATCGCCAGTC
ATTGGCTTGC
AAGGGGAACA
GTTGTGGATA
GTAAAAGATI'
AITGAGCGCC
AATATCAATA
ACGGGGGTGA
CAAACCCTT
TTGGAGTATI
AGCAACCCCG
AAAGAAGCTA
CGGTGTGAGA
GTGTTAGTCC
AAGGTGAAAG
TTTITI'GCTA
GGCTATATCA
AAA'ITGGCTA
CCTACCACCG
GTGGCGTTAG
GACTACATTA
GGCACGCCT
TI'AGCTFI'GG
CGCCTAAAGG
GTAAGA'TI'
ATAACCGCAG
GCGCGCTI'TG
GCACTGAAAT
TCCAAATCGC
AAACCTGTTC
CTGGCTTGAA
ATGATCCCAC
TAAAAGAGAT
TGGGGAGGGA
AAATCGGGAG
ATGAAAAAGA
CGCTCA'FTGT
TTGGGCCAAA
TATTGCAAAA
CCAAATTGA
ACATIAAGAA
GCGGGAGCGG
TAAACCATGC
TGGATAAAGT
CCACTTACAC
AAATTIAGG
AATGCCAAGG
AATGCGATAG
GCAAATCCAT
AATTCCCTAA
CTITAGGGCA
AAGAATTGAG
GTTTGCATTI
GCAATI'CCAT
TAGACATOG
TAGAAGTGGC
AATTGAAA
GGCGTGCGAA
AGATCCTAAC
TTATI'ACGCT
T=CAACGAA
CAGCTTTCAT
?I'ATGACATG
TTCGTGTAAT
AATGGCGGAT
GCATTI'TAAC
TIAGAAAGG
TGCGCGAACG
CGGTFI'GACA
CACGCTCAAA
CGTAGAGCAT
GGCTGGAAGG
TAACCATI'CT
ACCCCCTAAA
TTTGAGCGTT
TAAAAGCTCG
TAAAAAAAAT
GATTTATTTA
GGGAGTGATG
CTATAGCACG
CGATGGGGAT
CTGTAAGGGC
TGCTGATGTG
AATCGCTGTG,
AAACGCTACG
TAAAAAAGAC
TGAAGATGTG
GCTAGTGATI'
GCCTGATGGG
GCAAAATTGC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1800 1860 1920 1980 2028
S
S S. S S S *5 INFORMATION FOR SEQ ID NO:1088: SEQUENCE CHARACTERISTICS: LENGTH: 828 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscjfeature LOCATION .828 a.
S (xi) SEQUENCE DESCRIPTION: SEQ ID, NO:1088 GCGCGTTF T1TAAAATCAC AGCGGATTAT TTTTCCCCTA TGGAAAACGT GTIACCGC TCCATIACCA TGACGCTITI' ACTCTTGCIT ATCTATCCTT TCAAACCCTA CCGCTTGAAG AGTTACAAAC AAGGCGGTTI TAAAAAGCTC GCCTI'IAGGG TCGTTGTGGG GGGCTI'AGCC
ATGCTGCT
CAATGCGCGC
AGAAGCGCGT
AGCGTGGAAA
TcTI'TAGCGT
TTAGCGTTCG
TTITATCCA
GGGATTAGCG
GGGATCATCG
TTAGGCGATA
GGCTTGCTCA
T7TITTATAA TATTGAAAAA CTATTIATAC GGTGCTCCTT TAATFTCCGC ATGCATCGGG ATGTAGGACT AGTTGAAATC ATATCACTIT AAGGGATTTG CCTTTGGCAT GAGTCTTCTI' CAGGCGTTCA TATCCCTAGA GGACTI'TAGG cAGTATTTC CCCCCATTGA ATACACCCGC CATFTTTGGA TCTI'AAAAGC TTGCCTTGCC CGCTCTTTTA
ATITCGCTCG
TCCCCTTTGC
CTAGTGGGGGG
ATTATGGGCA
AGGGAATAT'
GGATTAGCGG
AAAGAGGATA
TTAACCTATG
ATTGTTTGGG
TCTTTAGGGG
AAAGAATTAA
CCACAGCGAA
TITT'CAAAGA
TGGTGTTGAT
TATTGAGCGG
ACGACAAGCA
GCATGTTCAT
T'FrTATGGAT
CTTACATGAA
GGCTA LWGTI'
TGGCTTGAT
AAAAAATT
CGCTTTCTCA
AAAGCTCAAA
TTCAGATCCT
GATcTTTGTG
GGCCGTGATI'
TGATATTCCT
TTCTTTAATA
CGCTCCTGCT
TGGGCTGTAT
CTI'ATGI'CA
240 300 360 420 480 540 600 660 720 780 828 INFORMATION FOR SEQ ID NO:1089: SEQUENCE CHARACTERISTICS: LENGTH: 807 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .807 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1089 .0
GTCATGCAAC
GAAAAAAAAA
GTCCTAGCT
GAC =rnITiT
GGCCAAAACG
TATCTACC
T1'GACTTACG
CTGGTGTTAA
TATFI'AACCC
GTTTGCCT
TTAATTGTGA
TIATAGACA
CCTI'ATACGC
CGAGCGGCTG
TAAGCCCCTI'
CAAGGAGCTT
TGGGGCTGI'
ATAGCGATGC
ATI'TGGCTTT
TCATAGGGCG
CITI'ATI'GCC
GCCFI'GGGCT
TTAGCGCITG
ACGCITI'AAG
ATACCGCTCT
CTI'GCTI'AGA
TCTATAAAGC
GCTTTTCCCT
ACAAAGCGCG
TGATTAAGC
GATGAGCGAA
GTGGTTTGTC
AAGATTGCCT
AAAGATI'TTA
TGGGGTGAAT
TTTGATTAGC
CGCGTTITA
AAAACGCTAT
TIITAGTGGG
ACTCATGCTI
CCTTGGAT
TTGCTT'
CTGTTATT
GAT1'TAATT
GAAATI'TCTA
AAAATCGCTC
'FITITGATCG
AAAAAGCCTA
CTCTFI'GCGA
TATTTGTATA
GACGGTGCGT
TIAAGAGCG
GATITI'AATA
TI'GTATTCGC
AAAAAGCCAT
TCCGITACT1'
TTATTGTCAT
TCAGCTACAA
AAAAAAGCGT
CTCACGTCAT
AAGACGCTCT
TTACTGGC
'TAAAACCCA
TCATCCCGCT
CGATCTITrGC
AAGGCTTGCC
CCTI'ATTGT
CGTTACTAGC
TXTATCCG
GGTITTI'TA
TGAAGCGAAA
AGCCATTTTA
CAACATGT T
TTATGTGGTA
TAAAAGCGTG
AAAAATCCCT
TTTACTAGGG
TGGTGGT'
TAGCGGGTAT
CCTCTACTAC
CTrI'ATGGCG 120 180 240 300 360 420 480 540 600 660 720 780 807 INFORMATION FOR SEQ ID NO:1090: i)SEQUENCE CHARACTERISTICS: LENGTH: 723 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .723 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1090
AGCCCTTT'A
AATAGCGATT
ATTTTAGACA
CTAGCGAGCG
GCCCTTAAAT
ATTTTGTATG
CAAATITAAAG
GTGAAAAAAT
TGCTTGGTCA
CAAAGTITTCA
AGCGC-TCTAA
ACCAAAGAAG
TGGATAGAAA
CGCTTTTTT
TAGGCTCAGG
TTCATI'TAGT
TCCCTAACGC
ATGCGATTGT
GGCATGCGAG
GCCTGAAACC
TAGAGAGCTT
AAGACAAAAA
AAGTTTTGCC
TTAAACAT
ACTCTTAAGA
ATACGATTTT
GTGTGGGGTT.
GGAAAAGGAT
TCAAGTGTTT
GTGCAACCCT
GCACCAGAGC
TAAAGGGTAT
AAAAAGCGTT
CGCCCATITG
CCCT1'TAATC
CTATCAAATT
TTATACCAGC
TCACGCCCTT
CTAGGCTIGC
AGCAAAATGG
GAGAGCGATT
CCTTTATG
GAATTAGACT
TTI'ATTTT
AAACTCACGC
ATGCTTGGAG
ACGCACAATT
TGTAACACTT
CCTTAAACGC
TTATCAAAAA
TCTGCGCTAG,
CGTTTTGCTC
TTTTAGATI'
CTIAGGATC
TCGCTTCTTT
GCTATGAAGC
TAGAAACTTT
CGGCTAGGAA
CCAAAAACCA
ATTCTATCAA
TTATTCTTAC
TAGCGGCGCG
AGACAACCCG
CCAAAAAAAC
TAACCCTCCG
TAFI'AAATCT
GGTGGCTAAA
CTI'GTCGCTT
AAGGTTrGTC
TAATTCCAAA
AAGCGACAAC
AGCGCC'TI'A
INFORMATION FOR SEQ ID NO:109l: SEQUENCE CHARACTERISTICS: LENGTH: 1287 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1287 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1091 S. S S *5*S
S
*5 S S 5
TCTCGTTCTI'
GGCTTGCAAG
CTITI'GGGGC
CCTGTTGTGG
TI'GGCTTGC
ATTGG TI'GA T1'GCTGGCTG
CTITTAGGGG
CATGGCACTA
AGCTTGGAAG
GGGCCTGTCG
AAAGACACTT
ATCACTGCAT
ACTTTI'IAT
1
TTGTGGGGG
TTAGGGGGCT
AAATTAAATT
GTI'ATGTGAT
GTGGGGTFi'n
AGTI'GATI'C
GCGCGGAT
TAGCGGGGTI'
TCAATCCTI'r
GTGCGGCATG
TGGGCATGGC
CTAAATATTT
TAGAGGGCGT
CCAGTTGT
CGCATFI'GAT
TTATCTI'AAG
ATTATATTAT
AGACATTTAT
TTCTAAAGTC
AGTCGC*TTTT
TTCTTTAAAA
CAAATCTFITA
TGTGGTGTGC
AATGGGGCI'
GGCTAAITTI'
GTGCGCGACT
GATTTCTAAA
GGTGTCTAAA
AGAAACTI'A
GCCTAAAAGT
GAACGCTTTG
GAATGTGAGC
GTI'AAAACTC
AATAAGATAA
GCCACTTTAG
AAGTTI'TAA
TTIATCATIGT
GATCCTTTAA
CAAAAAGGCG
CAAAATGCAG
TTAGGGGGAT
TTCACCCAAC
ITI'GGCTTGG
TACAAACTAG
GGTTTTGAAA
GCTCTCATTG
TTCACCTIAC
TCGTTTA
TTGAGCCTGT
GCTGTGCCTr ATTTGATTAA TAAGGATACA TGTGCATGGT T1'TGGTGTTG GAGATI'ATGA TATTCCAGAG TAGCGCGTCA ATTITATCAT TGCTGACTFI' CTTCATCACC GGAAAATGCT TGCGGTT TGGGGXTrC TATCGCTAGC CGATCGCTTT AGTGGGTGGG CACCTTATCA 'FTI'AGCTCT TGAGCGGGGG GATTAFTGGA AACCTAAAGA CACTAAAGAA CCCCTAAAGA GCAGCGCCTA CAATAGCT1T ATTAGTGGGG CGACTI'CGT GTGGTGTTG AAATCCATAG CGTGi"TG7AC TI1TTAGCTTA CGCTTAATG TAGcGGTTAT 'ITTGAGCGTI' 120 180 240 300 360 420 480 540 600 666 0 720 780 840 900 960 1020 AGAGAGGT1 CAGTTATAGG AGCGTGAATT TATI'GGAATT
CAAGTGGCGG
TATGATGCGG
GCTATGGTGA
GTCGTGCCTT
TT1GcTT
TTATGATCCT
CGGTGTTGTG
ATATGCAAAC
TAGTGGGAGC
TGCCTT'TT
TTATGTGGTG CTTGTAACCT CGCGGGGCAT TGCGGTTTT1G CATCACCAAC
CACTATGGGC
GTTTITTGTT GATATTATIA cCCTAGT
TTAGGGTATG
GGCTTGGAGC
CATCGCATGT
ACGCTTTAGC
CGGGAAGGAT
GACCCCAACG
GGCGTITATC
GATTAAAGGc 1080 1140 1200 1260 1287 INFORMATION FOR SEQ ID NO:1092: SEQUENCE CHARACTERISTICS: LENGTH: 573 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .573 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1092 AAATI'CGTTT TGCGTTCAAT GCCCTAGACA AAAGGGTGCT a. a a.
a.
a
GCCGCTATGG
ATTCTTTGTG
GGGCGTTTA
CAAAAAGAAA
GATTTAGAAT
GAGCCGTTTT
ATTCCTAGCG
CTATCACCAT
CTTI'AGAAAG
GGAGTGGGGA
AAACGCTGGT
GGGCTAAAAA
GCGATGTGT
TAGATTTI'GA
GGATAGATTC
GGGCGCTATC
TTCAAGGATA
TGAAGAATGG
GGCGGITTI'A
TAATGGAGGT
CTI'TGAAATG
AGTAGGGGTA
AGTAGATI'GC
AAGCCTI'TCT
TAAAGGCAGG
AAGTCATGCT
AAGATGCT
CTTTAAGCG
CAAAACGCTT
GATGGCTATA
AAATI'AGCAA
GTCATCAAAG
GTGGTAGGGA
CAAA.AAGCAC
GTGGATAAGAL
TAC
CAGTGTATGA
AAGACATI'IT
CTTTrGGGCGC
CTCTAGCCAG
AAAGCCCCAT
CATGGGAAGA
GCGCTTITAA
GCTTrAAAAT
GGCGTTTAAG
AAAAGGGAAT
AATGGAAAAC
TAAGGTCATT
GGTITAGTG
GTGCCAATTG
AAAGAATGAA
GGGCGGATTA
CGCTTGCGAC
GcGGATACGA INFORMATION FOR SEQ ID NO:1093: SEQUENCE CHARACTERISTICS: LENGTH: 1323 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .1323 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1093
AATGCCCACA
AAAGAATACT
GAATACTTGA
TTATTACAAT
AAGGGCATGA
GCGCAATTT1' TrI'CAAACCT
TTCATI'GACA
GGGGATAGCT
CTGGCCATTA
CTTTTTTATA
GGGGTTT'GG
~TTTCAGGG
AT'FTrGAGTT
ITGCTTTTTA
TTAAAACACA
ATCGCTFI'AA
ATTI TICGC
CCTTTGAGCT
ATGCCTIAA
TTGTTTFI'AA
AGCATGGGCT
GGT
ACTTGAAAGA
CATGGTGTGG
ATCACCAAAA
ACCCTAAAAC
TCTTTI'ACAC
TTGGCAAGAT
ATl'CTTTrC
GCGCCCATTC
TGAATAAAGA
GCGGGTTTCA
CCCCCTTACA
TGTGGG i-ii CGTTTT1'AAT
TTAAACTTT
GCGTGGGGTT
CTCAAATTT
GCGTGTITAGT
CCTACCAGCT
TGTTCTTGCA
CCATCCCCAC
CGATI'TTAAG
TTTICTI'GTA
TAAAACCrT
GGTTGTTTTA
GCTTGATTTT
GAA.AGATCAA
CACCATTAAA
CAAGCCTTGT
TTTAACGCGA
CAACGCCTTA
CTTAAGAGAC
T'ITAGGGATT
AAAACGCTAT
TTTGCTGGGG
GGGCTI'ATrA
GGTTTTAGCG
TTTGCTTTCT
TTTTAAAGAT
CTI iTGAAC
CTTI'AGCAIT
TGCGGTGGGT
GATTTCGGTT
CGTGCGTTTT
TTGTTGCTAT
CAGGGGGGGT
AGCCTTGT
TCAAAACCTA
AAAACCTATT
GAGCCTT'AA
TCGTICTIAG
AAACAAGATI'
GTGGGTAATT
AGGGCTAACG
'ITGAGCGCGA
TTCCCTITACA
TATI'TATTGC
GGGTTITrGG
TGCTGTATCG
GTTI'GTGGGG
TCT'CTTT
ATGCTCATTG
CCTITAGGCT
TTAGGGTCTT
TCTI'CGCCTT
TTTAAGGTTT
CAATATATTA
TTGAACTTCT
TGGCGATI'AA
CAAGCTTGAA
TTGTCTTA.AA
AAAACCTCCA
AGTCTCTAAA
TCAAATCGCA
TGTATCGAGC
CGCTAGGGAT
GCGTGTATTT
GGAACGCTTT
TATTAGAI'T
CATGC'TTT
CCATAGCGTT
TGTGGTATAT
TCAAGCGATC
TTGCGCATGC
TGATTITTAC
TAT'TGGATAA
TATGGCTTTT
ATTTAAGCAT
TAATGCCTAG
TACGACCCCC
CCTTTATITA
CGCTCAAATC
ACTCCAATCT
ATACCGCTAT
ATCATGCTT
TTTGCGC CAT
GTATCATA
CAACCACTTA
TCTTTT'CTCT
TTATGATATA
TTITACCCTCT
TGGGGTAAGG
ACTCCCTAAA
CTTFI'TGTTT
GTITCAAGCG
CTTITTTCCCT
TGTGTTITC
TATTCTAAGC
GGGGGCGCAT
GAATG7'TG
TTTAATTGTG
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1323 INFORMATION FOR SEQ ID NO:1094: SEQUENCE CHARACTERISTICS: LENGTH: 906 base pairs TYPE: nucleic acid IC) STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 906 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1094 a
GAGGCGTTTA
GATAAGGCTA
ATTTATGAGA
AGGGATAGAA
CATAGTGGGG
AGTATCCAAG
TGTGAAAAT'
CCAAAGGATT
TATCATAAAG
GAGT1"ITrAT
AATAAACTAG
AAGGGGGCTA
GTGGCTITAG
TCTCAAAACT
GGTTTAGAAT
CGACTA
AGGCGGATAC
AAGACTATAT
TCCCAACAGA
AAAACGCTCA
CGGGGTTGI'
CGTTAGAGTG
TCCCTAAAAA
TI'AAGAAGTG
AAGTGTI'ACA
CGTrATI'GAA
AAATCGCAAG
ATACCCTAAT
CCAAAGCAGG
ACACGCCTrI'
TI'AAGAATCA
GACTATCAGC
AGGGGAAITG
CACTTTTTA
CAAAGGCGAT
GAGCGCTTTA
CGAGATAACT
GCTCAGCGCG
GCTIGAATA
AGCCTI'AGAA
ATCAGTGGGG
GGATTFCT
CGCTCATCAA
CAGTGGCGAT
AGACGCCGCC
TTACGCTA
ATGGGCGCTA
AAAGTGGGGC
CTAGAAAAAA,
TACGGGCATG
AGCGCGTTAA
TCTAATAACA
TTCGCTCTTG
GCCCCATGCG
AAAGAAGTGA
ATCAATATAA
CAAAAATACC
GGGCGGGTT
GTGTI'AGCGG
ATTAACGCAA
ACGCCCCTAG
TCAAGTCATG
ATTrAGGGGT
GCGATTTGAA
CGCATGTGCT
GTITI'GGATC
AGCCTITAGA
GCATGGGGTr
TTITAGATGC
TCITAACCCC
GCATGCTAGA
CCAAGGTGGT
TTATCAACAA
GGCTGA'DTGT
GTI'TGGCGCA
ATTTGATAGA
CTTACTAAGC
T'TTAATCAA
ACTGCCCTTA
TTTGGGCAAG
TGGGGTGGTG
ATTGG?1Tr
AGAAAATATT
GGGCGTF-rT
TCACCCTAAA
ATTACTAGAC
TTTGCTITI'A
TTTAGGGAGC
AAGCCTACT'
CGCCCTAGCG
AAAGATCAAA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 906 798 INFORMATION FOR SEQ ID NO:1095: SEQUENCE CHARACTERISTICS: LENGTH: 1125 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1125 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1095
CTCGCTTIAG
GTGGGTTA
CCTAGTTTGG
GTTI'CTAGCA
AATTTICTTAG
GAATCGTTAA
CGCTTGCTCT
TTATGCCAGA
GGCATCAATI'
ITI'AGCGATG
TTTGAAGTGG
ACTTGCGCGG
CCTTTGCCCC
TCTGGGCCTA
TTTGC'ITTAA
AGCACGGATT
AAGAGTATCA
CCTTTAAAAC
AAGGTGATTG
CGTCAAAAGC
GCTTAGATGA
ATTATATCGT
C'ITTAGGGAC
AAGCCTTACA
GCAAAGAT IT
ATATTGCTGA
TTGACAGGTG
CTAGCGrI'TT
CCAGGATTGC
AA ITAGCTAG CGGAGITIwI=
CTATTGGAAA
ACCGCATCGG
AAGATTTGAA
ATGATACTAG
TTCAAAGGGA
TCGCTAAAGA
ATATTGCAGA
GACCGGGTTT
A.ATTAAAAAC
GGTGAAAATC
TTCCATGAAA
AAAAGCGTTA
AGAGGCGATA
TGCG ETCAGG-
GTITITTATCT
AACGGACGCC
CACTAAAATC
ATCTAATI'A
ATCGCTCACG
CAAACAAGAA
TCAAGGCATT
CATI'AAAAGC
TGATACGCTC
GCGAGTGGAT
TTTAGCCAAA
AGACAGAGAA
CCCATTGCAA
GATATTACCA
CCTCGC LTTG
AGCATTGGAG
TGCTCTTTGG
AAAAAGGAAA
TTGGGCGTTT
CAAATTCAAA
AAAAAATI'GA
AAAGAAAATG
CAAATCGCGC
CCTI'ATITGT
AAGTGGCTAC
ACACCCCAGC
CGTTTGAAA.A
AAGTGATGGC
AAAACAATTG
TCCGCCGGCC
CTGTGGATGA
AACTAGTCAA
GAGGGCTTAA
AAAATITAGA
CCCATTTTGA
AITCCACCTA
CATGCTTGCG
GAGCTFITGAG
ATTTGCCGGT
GATAGGGGGG
GCTAGGGTI'
CAATCCCAAA
AGTGTTTGAA
AGCAGAAGAG
AAAITI'AGGC
GGTCAGCCCT
AGAAGTGGAC
TGCCCCTAAC
AATCATAGGC
GCATGCGAGC
AGAAACCGTA
TGAATGTGTG
GGGACAAACC
CACGCCTTT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1125 0* C. *9
C
C
C C. C AAACAAGAAA AGAAAATCCT GAATTTGATT ATIGTI'GCGT GTCATGCTCA ATI'GCAATCC TATTTTGAAC CCATACA TTT GGCATI'ATCG TGCATITGG ATGCAAGCCC CCATTATTGG AAATTI'CCCT CTTTT INFORMATION FOR SEQ ID NO:1096: i)SEQUENCE CHARACTERISTICS: LENGTH: 456 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .456 4,.0 se C PCTIUS96/09122 WO 96/40893 799 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1096
CGTCCAGTCA
GAAAGCGCGA
AACCAGACCA
AAAGACGCCC
ACGCAAGCGA
GATGGCACTT
CTTTATr1'AG
ATAGAAGATI'
TTAGCGCCAA
TCGCTAAAAA
ACCTCAAAAA
CCFFI'TACAA
AGATI'TTCCA
CTAAGGGCGG
GAATGGGCGA
TGGTTGATGC
AGAAGGGAGC
TATAGATGAA
CGAGCTTTCT
ATrCCTTATT
TGAGACTTTG
AGCGATTTA
AAAAGAAGAC
GGTGTTTGTG
GATCCAAGCT
GT'ITTTATAG
AA.AATCGCGC
TTAGACGGCA
GCGCTAGATG
AGCGTGCTGT
GATTITGATCG
GAACAA
CTCTAGCTTA
ACACCCCCGG
ACACCTGCTC
CGCAAGGGAG
GCGTGATTAT
ATGAGTTGAA
CTTI'TGATGA.
CAACACCATA
GAGGTTGCAC
TAAAGTITA
F1'CTGGGCTA
GACTAAGCTT
ATTIACCCATT
AGAACGCT
INFORMATION FOR SEQ ID NO:1097: SEQUENCE CHARACTERISTICS: LENGTH: 693 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .693 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1097 0400
S
*SSS
p.
*5 *5e* S. 55
S
p* S
S
*5 5 S S .5 6 559*
S
.c
S
SSS*
*5 0 *0S S AMTrAAGGA
AGGGCTAAAT
CTCAAAGATT
CCTTTGATT
AAAGGCGCTC
CGT1'TGGGGT
ATTGTCGTGC
ATGTATGATA
TrI'GTAAGTA
GCAAATCTTT
CAGCGGGTI'A
CATGTATI'AT
?I'ATAACCAT
CAAAAAATAA
ATCAAAATAT
TGAAGTrAAG ATTrCTAA
GGTTTGATGA
CGAITI'TAGG
GGAGTTTACC
GGGAGTI'AGC
ACATGAATGC
ATTTACATTT
GTGATGAAAA
TAAAACGATI'
AGTCAGGGAT
TI'TATTIGTAT
ACAAAAAAAT
AGAGGGTTT
GCCGAGTTTG
AATGGATACA
CCAATIATTC
GCTGGCTAAT
TCGTATCGT1'
CATI'AGAAGT
AGATCTATrA
TITAGAGATI'
AAATTGGCTI'
AGCCCATI'AG
AAGCGCGTGT
ACTATCGCGC
TCGCGCTAT
AGCTrAGGC
AAAAAGCAAC
GGTATTCTTA
ATGAAGAATA
CTTGGTAGCG
CC
TTTGTAAAGA
GCAAGCTTI'
GGCATGAGCT
GGTTGCCTAA
CCTITAGGTT
ATAAGCGGGA
GCGTGGGTTT
TAAAACGCCC
CAGACGCCTA
ATAAAAGGAA
TGTTTGATCA
ACGCTTGAAA
GTTITGGAAA
TGACATTAGG,
AAGCATCAAA
GCCATI'AAGG
A'ITGGATTGT
TGGGCTAGGC
CTI'AGTCATA
TGACATTGAA
ACAT1'ATGAG
CCGCTCTAAT
INFORMATION FOR SEQ ID NO:1098: SEQUENCE CHARACTERISTICS: LENGTH: 600 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATRE: NAME/KEY: misc-feature LOCATION I1.. .600 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1098 AGAATAATAA AAGGAAACAT GTAGCGTGTT TGATCACCGC
AGAGGGCAAG
AAATCTITTCG
CAATATGAAA
AAGCATTTAG
GAAAAAAAG
AAACAGCGCG
ATGGCTIATA
GAAGCGCAAA
CCATTITAAA
TGGAAGCTGA
ATAAGAATI'
AAGCGCAGCA
AGCTTGAAAA
CCATTITGTAA
CCAAAGATGA
AGAGCGCCTT
TATGAGCAGC
T.CTAATCATG
AGGCGCTTCA
AGAAATGCGC
GCAACTCCAA
CAAAGAATTT
AGAACGCCAA
AGAAGCTCAA
AATTAAAAGC
GATCAGGCGT
GGGITTAATIT
TATI'ATGTGA
GCCAAAGCTA
ATGAAAA.GCC
ACCCATFFITG
GTAAGAGATG
ATI'TTAGAAC
GCCAAAGCGC
ATGATCTTAG
TATGAAGAAG
ACATTTCATT
TGAAAAAGAT
AATTAATGGA
AAGAATGCAA
ATAAAAAAGA
AAAAACGCTA
AAGAGAGGGA
TAGATGCGAT
AGCAATI'AGA
AAGCCTTTAT
AGAAGTCITG
CTATTACGCT
ATITCAAGCG
GTTGCAACAG
ACCGCATTTG
TTTGGAAAAG
AAATTTTAAA
GCTCAATTAC
ACAGGAACTA
TATGTGTI'TA
INFORMATION FOR SEQ ID NO:1099: SEQUENCE CHARACTERISTICS: LENGTH: 1050 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAIM2/KEY: misc-feature LOCATION .1050 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1099 0.0 ATAAGGTCAT CAAATGACAC CCAAACCACC CCAAAACCCA CCCCTAAACC CATTAAAAAA AAGCATGCGC ATTCAAAGCA TGCGCACTCT ATTCcTAAAA AAGAAATccc TAAAAAAGAA ATCCCTAAAA AAGAAATCCC TAAAAAAGAA GCAGAAAATG AGAGTAAGAA CCAAATCT ACCAAGCGCA AAAAACACAA AAAGATCGT GGGGCGATGA GCGCGAATTT GGTGTGTGAA TI'GCATAAAG AGCTTAAAAA AAGAGGCTAT TAcATTA TAGTGGCCCG AACfGGAATI'A TCAGTGCATG CCAAF'C CAT CCCTAAACGC TATTFTATCCACCGCAAG GAGTGAAAGG GACGATGTGA A TTAATGGA CTATFTrl'CT CAGCGATTGA TCGTCTCCAA CAAAFTAGCG GTCCGCAAAA AT1'ACCCTGA TGTGGTGGAT TIAGCCGGGG CTTTAATGCC TTCAATIT1' A GAATCTAAAC GCATCCAAAG CAAACCGTAT GGCATI'GATA GTITCI'CAG CAAGAATGAT
CAAACACCAT
GAGGCTAAAA
CCATI'GAACG
ATCCCTAAAA
ATCCCTAAAA
ATAGCAGAAA
TTGGACGCTG
AAGGACATTG
AGCGTI'1TAT
GCC?.ATAAAA
TCCACCTCTA
GCTAGGA&AG
AAAAG'ITTGT
ATTGACGTGC
GGGGGTGTTA
ATAGAAATIG
CAAAAAATCT
GGCACTCAAA
AGGCTAAAGA
AAAGGAGCGC
AAGAAATCCC
AAGAAATCCC
AAAATGATAC
GGCATGGGGG
TTTAGAAGT
TGACAAGGGA
AAGGGGCGGA
ACGCCCATGG
TGGCTGAGCA
TITTTAAATTC
AATACGGCAT
GGGAGGGGCC
GT1'ATAATI'C
TGGCTAAGGG
CACCAGACGG
GAAAACAACT
TAAAAAAGAA
TAAAAAAGAA
TAAAAAAGAA
TTGGATCAAA
GAAAGATTGC
GGTGAAGTTI'
TAAGGACATI'
TTrATrCATC
CATAGAGACT
AGAAAATAAA
ATI'GAACACG
GCTCCAAAGT
TTTTTGGGTG
CCATGOCGATA
CATTGCTGAT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1050 INFORMATION FOR SEQ ID NO:110 0 SEQUENCE CHARACTERISTICS: LENGTH: 558 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .558 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:ll00 *e AGAGTATCTA TGAATGTCAA GAITGTIGG AGAAACTTGG AGCATTGGTC AATTAGCGAT GGTGGGGTGA TGAGTAAC TTAGCGCGTC AAAGG-CGTAT GAGATGTATC AAAATCAATI TTCTT=AATG AAAGTTI'TGA GCTATAGCAG TCAATAACAA AAGCAAGAGT GCTGGGAATT CGTGGAAAAA CAGAAATI'
AAAAAAGGGA
GAAAGAAAAC
CCCCATTCCT
TTTTrATGAT
TGAGATTGAA
TAATGAAGTG
TGAGCTGGAG
GATCCAAGAG
TATCACTAGC
AAGCCACAAA
ACTACTTIT
GGAGTTGGAG
GTCTCGCTAA
AAAGAATGCC
TTTGAGCGGT
AGGGCGCTIT
GGGATGGGTC
CGTAAAGAGG
GTGGAAAGAT
TAAGCAGTAT
TGCTCATTGG
CGATTTTCAA
GTGAGAGTAT
AITTTCATGG
GTGCGGGCGA
AAGAGTTGCT
GTTGGAATT
TGATAGGGTG
AGCTATGGGG
GGGCTTTGTG
AGAGGCTAAA
CAGACAGTTA
GACTATAAAA
TGCGGAT1'G
GTTTGACAAT
CGTCACTAGC
120 180 240 300 360 42C 480 540 558 INFORMATION FOR SEQ ID NO:1101: SEQUENCE CHARACTERISTICS: LENGTH: 1086 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 1086 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:ll01 AAGAGGGATC AAATGCGCCGA AAAGCCAGAG AAGAAGGCAA ~TTGCTGGGC TAATGAGTAT ATGTATCGCC ATGTGT1'GAA CTGTTTAACC AGCTGCCTAA ATGGTGGTGG CGTITTTGTC ATTGAGCCTA AATITCTAA AAAAAGATCC TIGATGGAG TT1TTCATCT =ICCTTATT
AGAAGAAAAG
TGTGCCTAAA
TTTGTITTT
AGATTTCTCC
AGACACTI
TAATGTCTTG
AATCAACCCt
TTTGATCACT
TAGGGGAA
ACCGAACTCC
AGCATGGAAG
'ITATATGGT
CTAGATITTA
TrATrrGCTTr
CAATTTGGCT
ATCAATGGCG
TTAAAAGITI'
TTAAACCATG
CTAGCGCGAA
TGGTGGGGTT
GGGTGGATGG
GCAAAGAAAG
TGCCTCTITT
GGCTCTTTGC
TCAAAAACCT
TITAGCTT
CGGCTCTTTT
AAAAATCCAA
TTTAGGGTITA
CTTTAGCGAG
CGTI'CAAGAG
AATCATTTTA
CCCTAAAGTC
TTTTTCTTTA
TTF1'CTGGGG
GAATTTGCAA
120 180 240 300 360 420 480 540
GGCCAGTTGT
TrTTTTGTCT
AAAATGACTA
AAAGCCAAAA
CCCAAATCCA
GAAGAACACC
AAGGGTATCG
CTrTATAGAG
ATTGTCTICG
CCTCTI'
TGTGGTTTAA
TGGC I ITGT
AACAAGAAGT
TCCCCCAGAT
ATGTCGTGGT
CTGTGCCTGT
CCAGAGAGCA
ACGTGAAATT
CTCAAGTGGC
AAGCAAGGCG
GGATTAATC
TAAGGACGAA
GATGGTAAAA
GACTAACCCT
GGTAGTGGCT
TGACATAGAA
GAACGCCACC
TAAATTAGAG
TTATGGCTCA
ATCAAACGCC
TACAAACAGC
AACGCCACGA
ACCCATTATG
AAAGGCACGG
ATT1ATAGAAA
ATACCAGAAG
CAAGAACGCC
TTTCTTCGCT
GCCAATACAC
AAGAAGGAAA
ATAAAATGAT
CCGTCGCTCT
ATTATTTAGC
ATAAAACGCT
AATTGTTI'GA
AAAAACAAAA
TTTATTITTA
TAACTCTFI'A
CCCAGAAATC
GCAAGAAATC
CAAATTTGAT
CA'ITAGGATT
CGCTAGAGAG
AGCGGTAGCG
GATCATTAAA
600 660 720 780 840 900 960 1020 1080 1086 INFORMATION FOR SEQ ID N0:1102: SEQUENCE CHARACTERISTICS: LENGTH: 543 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .543 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1102
SS.S
S
*5 555
GAAAATACTA
GACAGAITAG
TTICATCACGC
TTAACCCAAA
AACGAACAAA
TTAGGGGCAG
AGAGCGTATC
AAAAAACGCC
ATTAGAAATC
CAA
TGCAAGATT
ATACTTATGA
CTAAAATCTC
TTAAGGGGAG
AAGAAAAGAA
TGGTTIAGGCT
GTGAGAGC
TTCFFI'ACAA
GCACGTATCA
ACAACATTTC
CAGCCTAGAG
TAAC1'TAGAG
CGAATGGGTG
AAAAGAAATC
TATTTITTTGT
TTATTATCAC
TTATATI'AAA
TTGGGAAAAT
AAAAATGATA
CAATACAAAG
ArI'TATrAC
ITTAATGAAA
ACGCATTCTT
TATAAGTTAG
GAAAATAAAG
GCCCATATTG
TTACTCAAAA
TTACGCTCAT
AAAATTTAAA
GCAACGCTTT
ATI'CTTTAAC
TAATCTTATC
AGGGGGTAAT
ATACCTTGCT
CTTTAAACTT
TCCAACCGAA
TCTGTCTAAA
ACTCATTTCT
AGACTAFI'GC
AGATTTAATT
TAAAATGTCT
ATTAGAT'TG
TATTAAAGGC
GCTATGGACA
CAACCGCCCA
120 180 240 300 360' 420 480 540 543 INFORMATION FOR SEQ ID NO:1103: SEQUENCE CHARACTERISTICS: LENGTH: 567 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .567 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1103
GCTAATGGAT
AAAAAAGCGG
TGCCTIAAAA
CCAGAAACGG
TTI'AGCCATT
CAGGCTCTFI'
TTFTGCTAAAA
TTAAGCGTGG
GTAGGGCTTA
GAAAACATCA
GCGAAAAAAG
TGCCTATTGG
ACCCTGATAC
AGAITTI'GAG
TAAACAGCTA
TTGAAAGGGT
AAATGGTTCA
CTAAAATTTT
ACGCGCATAA
TTGATAGITI'
GATTTTCATG
TGTGGGCTTG
AGAAAGCCTT
CGTGTTTGA.A
CACGCCTTTG
GCGTGTGAAT
AAAGGGCGF1'
TTCTTTAAAG
GGAATI'TAAA
GATAGTI'
CTGCTTTGCG
ATAGAGAGCG
ATTI'ATAG
AGCATTGAAG
GATAATTTCA
AGCAGTAACT
TTATTAGAAA
GCTAAAGGGA
GAAAACCACG
CGGGAAGGAA
CGATCAATTT
GGAGCGCGGG
GdTATCAAAT
TTCACATAGA
ACATCCACAC
ACATGGAGTT
TTF1'TTGCGT
CCAAAGTCAA
TGAGACTTI'A
AACGAGAATG
GAGTTATAGC
TGAAGAGAGT
AACTAAAGAG
CAGCGAAATG
TTITAGCGTC
GAGCAATCAT
ACAGATCTA
INFORMATION FOR SEQ ID NO:1104: SEQUENCE CHARACTERISTICS: LENGTH: 1018 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1018 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1104 TTTIAATGAG TTTATAAGC AGAATTTGTG GA TTT GCCTA GGAG TTGGT TITGTGGI'A CATTATTGCT GTTGAAAATG ACAAAGCCAT FTACCCACTC GCAATI'TAAC AACCAAGCGT AGCGACTAAC ACCGATATI'A GTITGACCCA AAAATCGCTA TTATATIGTA ACCACCAACA AAAAAGAGAG CTGGATACAA TGAGGGCATT GATGCAGGCA CTCGCTTAC TATGACGCTT GAAAGAAGAA AGGATTGATG AGAGCCTAAA AAAGCCAATC CCAAAAAGCA GAGCGAAAAT GAZAAAAACT AAAGCCACCA AGAAAGAGAT GAAAAAGAGC
TTGCAATCGC
AAAA.AATCAT
CTCAACTTTC
GCGTCGCAAC
CAAGAATGGT
ITITGATCGC
ATTTCATTAG
ATITAAGGAA
CGCTCAATAT
GCGGCGTTAC
CGCTAGGGAA
TAGTGAAAAA
CTAGAGAAAA
AAGGCACAGA
TTGACGCTAA
AAAAGGCTAT
TTGAAGAAAG
CTCTGGCAA
CCGTTCCG
AGATTATGAA
GGCTAAATTC
CGCTAAAAAA
TCCTAATGAT
CTCTGATTTG
AGCGTGCAAT
TTAAGTTGT
TAAAACTTCC
ACTITTCA
AGAAAAACGA
TAAACGAGAA
AAACGCTCCC
AGAAGAAAGG
GGAATTTGAA
AAGAAAAGCT
6AACCCTrAA
GCCCATGATT
ATCGTTAATT
AAAGCGTTrG
GGGGATTTAG
GAACTCTATG
TTGGTTACTT
GTTTATAGCG
GAGAGTTG
ACGCCGI'?T
GGCAGTCAAT
AAAGAAGTAA
ATCAAGCAAG
ACTI'TAGAAG
CGTCGTTCAA
CAAAGAGCGA
TI'AGAAATGA
GAGTGAGTAT
TGAAAGTGGG
CTGAAGTGGT
AGTCGATGAA
TCTATTTCAG
AGCAAATCAG
?TTGAATGG
TGGGGGTGAT
AAATTAGA
TITCTAGGGT
CTAAAAATI'A
GGATTGAAAA
AAGCCATTAA
AGAAAAACTA
GAGATGAAAG
GAGAACATCA
ATAAGAAG
120 180 240 3,00 360 420 480 540 600 660 720 780 840 900 960 1018 INFORMATION FOR SEQ ID NO:1105: SEQUENCE CHARACTERISTICS: LENGTH: 852 base pairs TYPE: nucleic acid STRANDEDNESS: double JD) TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .852 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:llOS
GGAGAAACAA
ATTI'AAGTG
ACGCCTGTGT
AAAGACACAC
AATAAACAAG
GGCGATGCCA
GACATTGATT
AACTACAATG
AGTCAGCCAA
AACAACAAGC
CAGTATTACA
CAACGAGAAA
ATTAGTTCTG
AGGGAGAAGC
CTCAGTGGTA
CAATGAAACT
CGTGCAGTAA
ATAATGAACT
CATTCATGGT
TI'GTACTAAC
ATAAGATCCT
TITACFI'GCA
ATAATCCCAA
TGCTAGGAGC
AAGTGATCAA
AGACTCTCTI'
TITIAGAAAC
AGA~TFIAA
TACAAGAAGA
AG
GAGAGCAAGT
CTATGCGAAA
GATAGAGAAG
GCAAGTGAAG
TFI'CAAAC'T
CCAATACAAG
ACCCACTTTG
CAACAAAGAA
TAACACAAAA
TGAAGTGGCA
GCAAGACAAG
ATTGAGTAAT
GAATGGCAAC
AAGAGAGAAT
GTTTTAATCG
AAAGTGGTGA
TATACTOAGA
TTGCCAAATr
GTTCACCATT
AATTACTTCC
AATCAAAAGG
AAACCACAGA
AACTTGCATG
AGAGAAAAAG
GAACAAGAAT
CGTGCAGGTT
TTGAACATGC
GAATACTTGC
GTGTGGCAAT
AACAAAAGAA
TCCCCTTAAA
ACAAGGACTA
CTAAAAAGAT
AAGCTAACGG
GTGTGGTGAT
CCTTTGATGT
GCTATGATGT
CTCAGCTAGA
ATACCACTAG
ATCAAATGAG
AAGCCAAAGA
GCAATCAAAT
TCTGTGCTTA
CCATGTTTAT
TGACAAACTC
TTTGTTGGAT
TACGCTCATA
GGCAAGATCT
GATAGCGAGT
GTTGCAAGGA
GAGTGGAGCA
AAAAATCAAT
GAAAAATAAC
GCAGAATGTG
AGAAGAAGT1'
CAGAAGTTTG
INFORMATION FOR SEQ ID NO:1106: SEQUENCE CHARACTERISTICS: LENGTH: 723 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .723 (xi) SEQUEN2CE DESCRIPTION: SEQ ID NO:1106
AGTTATTGTC
GTTTTGATGG
ACCAACCAAC
AATAATAAAA
GGAGATTTAG
GATGTGAT1T
AATCCCTTAG
C 'TATI'GTG
AAATGAAAAC
CAGAAGATAT
AAGTGCTCAA
TAGGTCAAGA
CGTAT1'GAA
TTAAGACTTA
ACCAAAAGAC
AGGCGAACCT
ACTCGTGAAA
AACAAGCGGC
AAACCTAGAT
AGATGCTCTA
AGCCAATFT
TATGTCTAGC
TGCTGAGCAA
GAAAPLTCGAG
AATACCATAT
TI'AAAGCAAC
GAGATITI'IT
AACATCAAAA
GAAGCGAATG
CCTGAACTT
CAATGCGGAA
CAAGAAAAAC
A'ITC TMr1
TGGATAACAC
CAACCACTAG
AAGCGGCCAT
AGTTATTTT
TATTAACCTA
TATCCGATAA
AAAATATAAG
GCTATTGTCT
CTACCAAGAG
CCCTAGCGCT
TGCTITGAGA
CATCTCAGAA
TATGAAAATC
AGTTIAGTT
AGAGCGTTTA
120 180 240 300 360 420 480 GAAACTI'CTC TAAAGGCATA TCAGAGCAAC ATTGGAGGTA TCACAGACGC T1'GTAGAAAG CCTAAAAAAT AAAAATTTCA ATGTTAGCTC ACAACAAGGT CTTTTTAAAT TATTTAGAGG TCCCTAGAAC AAAGTAAGCG ACAATACCTA CAAGAAAGGC
AAA
CAGCTTCCTT
TCAAAGGAAT
AGTTGGACGC
AATCAAGTAA
AATCACTGCT
CAAAAAGCTT
ATTAGAAAGA.
GATCATTGTT
INFORMATION FOR SEQ ID NO:1107: SEQUENCE CHARACTERISTICS: LENGTH: 1617 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAM~E/KEY: misc-feature LOCATION .1617 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1107
S
S
*5 S.
S
S.
*5*S
S
S.
S S
ATAAATAAGA
CTCATTGTTC
TACCAAACAG
GATATTF1'GA
GGTGTGATCG
AAATATFI'GA
ATACAAGGT'
AATAAAAACA
AATTACCA
GGCTCAATAA
GGTAAAGAAT
GCATIAGAAT
AATCTGCCTG
TATATTGTTI'
GGCATI'CAGA
ATGGCGATGG
TCTATTIAI'
GATITAGTGC
AATGTI'GGCA
TI'CGCTAITI'
TTGATAGCGG
GATTGGTTCA
TTGGTTCTAG,
ACCATAACGC
ACTATI'GCGA
AGCGTC.AATG
GATAGAGAAA
ACATG'FFIAA
CTAATI'GGT
TTI'ATTGCAT
CAGGCTATAC
AAGCGCTTAG
ATACTFITAGG
TI'GCTCTAAC
TAGATGTATC
A.AGGCGGTGT
CCGCTCAAGC
TCACTGCAAA
CTG'ITGTCAA
ATATTATCAT
'rrGGGATTTT ?1'AACATAGG
TCTCTITI'AT
T1'GGTTTAGC
TGAATTIACAC
ACAACGCTCC
TTATGCAAGT
GGGCTTAG
AAGATrrCTAT
CTATTCCTAT
CCTCTGTI'GC
GTTTGATCAC
CGATCGTTAA
GAGATGCCT'
TATTAAAAGG
GAAAGCTATT
GCTGATACCG
ATCTATTGGT
CACACCATTA
TCCITI'ATGG
GCCATCAAGT
CATGGATAGC
TGAGGACAAT
TrCTACGAAT
TAAACTGCAA
AGGAGCGGAC
AGGGCAAGGG
TGTITTTAT
TTGAATAC
CGCCTATGCA
AGGTGCTTT
TGTTAATTCA
TAGTITGT'A
AACTATCATT
CGGTATTGT'
GAAAAACATA
ITTGCTCTT
TATACAAAAC
TCTATTTATT
CACCATTITC
ACTTTTTTAA
GATTTGCCCA
AGTTATGTTT
GCATCAGGGA
GCCACAAGTT
GGATCGGCGT
GGCTGTAATT
GTACTAGACA
GTGAAAGGCA
ATTACAGCTG
AACAACACTA
GCTGCTGTTC
TCATATC'rrG TCT1'TTATGA
ATGCGATT'G
GGTTITGGTT
GGGCTGAATC
ATI'TTACCTG
CAAGGCTTGC
ATGAGAATAA
TTCCCTAITG
TTGATATGGT
GGTG'TrTTGG
ATCAATCAAG
TTAAAAGGT
AGCTCTGTCT
TAACGATCAT
TTGTTTCAAA
TAACCAACAA
GTGGAAAGAG
TAGCCGCTAG
'GGGCAAGTGT
TTGGTI'GGAA.
ATTTGAGCAA
ATATrC,..rT
ATGGTTTAAT
TAGCCATGCT
TTCCTGCATA
ATTrTGTTTC
AAFI'GAGAGA
TTGGGGGGAC
ATCTTTATAA
AAGTTCTTIT
CGGTAAGAGC
AAGTGGCAGG
GCACTGTTGT
CAGTATGTTT
TTATTAATAA
CATTATTGGC
GGGGATTGGG
TCATAGAGAC
CTATGGATGG
GATCTATGT'
AAGTTTTTT
TCTCAAAATT
AAGTTTTGCA
TTCAGGGCAG
CAATCTGGTG
TGCTACAGCT
CGCATTGATA
CAAGATI'CAG
ACAAATAATT
TTGGCTGATT
TGCTI'TTGCC
TGGTGTAGTC
TrACCTAATT
TATITCAAAC
ATTATI'CAAA
AATCTCTIAT
TTGGGCIT1'A TGTTrI'CT
TATTTCTT'A
TGTGAAACCT
GATCGTGCTA
TCTGTTTATC
ATTCAATTTG
TATCGATTCA
GATTATTrGAG,
TAGCAGAATG
TAAAGGA
120 180 240 300 360 420 480 540 600 660 720 780 840 9.00 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1617 AATGGTGGGA AGAGITGGTG INFORMATION FOR SEQ ID NO:1108: SEQUENCE CHARACTERISTICS: LENGTH: 768 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .768 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1108
CTCCATAGAA
AAAGCCTI'GT
CTAACAGTCA
ITAAAAAAGA
ACCACAGCCT
AAAATAAGAG
TATGTGCATA
CCTGAAAAAC
TATTTTGGTT
AAATTGAGCA
TATAGAGTrA
GTGATCAATA
GGTGAA'ITGG
F1'ATCTCCTG
ATCAATTCAT
AATTAGAATA
GAGAAGAAGC
ACATCAATAG
AAGAAAAACA
ATGCGTTAAA
GCTCTAAACA
TCAAAAACAT
TGACTGATGC
ATGAAATTGC
AAGGCTATGG
AGCGTGTGAT
CGATAGCGCT
TTTGAGGATA
CCCACAAAGA
AAAGAGGCAG
AGTAATGATG
AAAAATTATA
AAGAAACCCT
TATTATGCCC
CACTCTCCAA
CGCCATTGAT
AGAGAAGTTT
GAAAAATCCA
TAAAAAGCTC
TGGAGGACTA
GCCCAAAAAG
CACGAAGTCT
AGAGAATTGA
GCGAGCAATG
CTAGATCAAG
GTGCCTAGAA
TCTGAAATTT
CCTGCTATTT
CCTAACATGA
AAGCTCATI'A
TTGACAAAAA
CCTCTI'GTCA
ATCTTGTTGT
ACAATITGC
CTAGCGTTAT
TCAAGCAAGA
AACAGATIAT
CAAAGGCGCT
ACTACAATTA
TTGATGATGG
TIGTGGTTCA
CTAATTCAGG
AAGACAAAGC
ATTACAATAT
GAGATAAA
GCGGACCAAT
TTCAGCGTAT
TGAAGAGGAA
AAATCTCAAC
CAACAA.AGAA
AGAGACCCAA
CTACCAAGCG
CACATTCACT
ACCTGATGGG
ATTGAGATGG
CCTTGTA.ACA
CAAAAACTAT
a a 9*4 INFORMATION FOR SEQ ID NO:1l09: SEQUENCE CHARACTERISTICS: LENGTH: 363 base pairs TYPE: nucleic acid STRKNDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .363 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1109 ACTAG7TC77
CAA'ITCAAAC
AATATCAGCT
ATITI'AGTTT
TACACTACTT
AGCCACGCAA
TA
TCAAAACCAA
ATICTFICAA
CTATCGTI'AT
ATCCAATATT
ATCTTGCT
ATTTCACAAT
AATGAAACGA
CAAACAT1'A
AGGTTI'TA
ATTCTTGTT
ACTCGTTTCTT
GAAGCTAATC
CCGATCAGCA
GATAAGTACA
ATAGCGCTTT
GCTCTI'ATAA
CTCAGCATAA
ATGCTTATGA
AATI'GAAACA
GCCTTTATI'A
TTTCTATGG
TAAAACCTAG
TAAGCAAATA
CTCAATGGCA
AAACTA
TAGGCTGTTC
GGCAGGGGTG
CTTTrAT
CTATCTCCTA
AAATTGGTTC
120 180 240 300 360 363 INFORM4ATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 393 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: mi.sc_feature LOCATION I1.. .393 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1lO 0 4* q. S S t, We
S.
St..
GTATGCTATT
CTI'ACACAAC
GGCGGAACAA
TTGTI'CTTCC
CCTATGGACA
AAAAACATGG
ACTAATAAAA
GTGAAATGCT
CAAAAATAAA
ATCTTITI'AC
TGATGTTAAT
ATATCAAGAA
GATCTGCTTT
TGAGTGTCCC
TCCTACTAAA
AGGATTGAGT
AGGTTTATCC
GATGGGACTT
TTTI'ATGGCA
GGTTGGTAAT
ACAAGTAAGA
ACACGCATTA
ATGGGAAAAA
AGTGATTTGT
AATGAAGCAT
GAAGTGCTGA
GGTTTI'GGTA
CTC
GAGATCCGAA
TTTTAGCTTC
TTI'CTATGAT
TAGGGAAAAA
AGAATGGATT
GCAGCAAATC
CAAGCAAGAA
TTTGTTGGGT
ATTAAATTTT
ATTTAACTTG
CGATAGTATC
AGACAAAACC
INFORMATION FOR SEQ ID NO:llll: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 891 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .891 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:llll
S.
S S
GAGGAATTGT
TATrl'ATTTT
GGTAGGGTGA
ATITGGACT
TACATCACAA
ATTCAACCTA
CTAATGACAA
GACCCTAAAG
CAGGCGCAAA
AGAGCCAATT
AAAAATCTTA
TGATGGGGCA
TATCTAGCGC
AAGTGGTGAA
CAT1'AGACAA
CAGGTITCAA
AATCGGTAAA
GAGATTACCA
AATTAGAAGA
AGGCACAAAA
TAGAAAATCT
GCGAATTGAT
GGCATITTT
AATAGAAGCA
TAAGAAGATT
TGTTACCGTG
TAAAGGTTGG
AAGTAATCTC
AGAATTA
ACAAAAAAAA.
AGATAAAAGA
CACTAACGCT
CAAGCAACAG
AAAAAAATTG
GTAGCACTTG
GCT'A'TI'GG
ATCCAACT1'G
AGTAT'GTIGC
ATGTTTGAAA
AAGACAAAAA
GCTCTAGAAA
TT1GGCTGTTT
ACATTAAGAA.
GAGATGAAAA
AAAA.AGATGA
CTAATTCTAA
AAGAAGCAGT
AAC'ITATCGT
AAGAAAAAGA
CTGTCTTGGT
TTTTAATCGT
ACCTATTACG
AACTATTTCT
TCATATATTC
GAATTTTGCC
AGATGCGCCT
AGCTAAAGAA
TGCAAAAAAT
GAGCAATAAC
AATGGAACGA
120 180 240 300 360 420 480 54 0 600 660 GAAAAAAGAA AGGAGGAGCG ATGAGTAACC CACAAAAT AGAGAAAATG AATTAGACCA CTAGAGGACA TGCAAGACCA GGCTCAACCT AACGCACTCA AAGAAACAAG CTGAAGAGGC AGTTAGGCAA AGAGCCAAGG GATAAATCTC AAAAAAGCCC CGAGGATAAC TCCATAGAAT GGAGGACTAA TCTTGTTGTG CGGACCAATA AAGCCTTGTA
AACAAATTGA
ATAAAATCAG
TATCTCCTGC
TCAATTCATT
AGAGCTCAAC
TATTAAGACA
GATAGCGCTT
T
INFORMATION FOR SEQ ID NO:1112: SEQUENCE CHARACTERISTICS: LENGTH: 765 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1. 765 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1112 :0
AGCTGTCGCA
GGTGTGATAG
GCTITTTATC
CCTI'TGAAGA
ATCGTCAAAC
ACTTCAAAAT
GATCAACTAA
GAAAATATCA
CAAAGAGAAA
ATCACGCCTG
TATGATTTTG
AAAGTGTITG
AGAAAGATTA
TGTTAGGGAA
CCCTTGATAG
TCTCTATGGT
AAACAGATAT
GCTCCGATGC
TTGTCTCATI'
TGCAGTATTG
GACAATTCGT
AAGTCAAAAA
ATACAATGGA
CTAGAGGTAA
ACA'FrCAAAT
AAGAAGTGGA
AAAAAACGAA
ATTGGCAAAA
GCTCAATGTC
ATTTGTrI'AT
TAGGCAAATC
GCTG'ITTGGT
CGATGTGAGT
AGATAAAGTC
TAGTCCCTTA
AAATTATGAA
CTCTTCTCAA
CACGGATI'TA
ATCAAAAAAT
GAAGTCTTGA
CTCAATAAGG
GCCGCTGTAA
GGCATTGATC
GTCAAI1TCTG
TATAGCAAAA
TI'CCAAACCC
CGAGCAGAAG
ACGAGAEITAA
TATATCACTA
GAAAATCTTA
CAAAACGAAC
AAGGCATTAA
TTGATGAAAA
CCAATAGGAC
CGAGTATTGT
GATACACAGG
AAGCCGTTGT
ATrCTTTGAG
AAGCA.ATGAG
CTATCATTAG
CATITI'TCAT
AAAAACAAGT
TCATCAACCC
AGACAGTAAG
ATAAA
TTTGG2IGGG
TTFTCAAAAGG
GATGATGATG
AGAATTTAAA
GGATAGTGCA
GGATCGCAAG
AATGTTCAAT
CTCCAACATA
TACCATCAAA
AACTATT TAT
'TTTGGCTTC
CGAAATTT'G
120 180 240 300 360 420 480 540 600 660 720 765 INFORMATION FOR SEQ ID NO:1113: SEQUENCE CHARACTERISTICS: LENGTH: 750 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: -DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .750
S
(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1113 AAG CCCCTAA AAACAATTrC
GGATCCAATC
TTGCTAGACT
AAGAATCAAG
AGGTATGAAC
CATTCATTCT
ATATTTGTTT
GTGGAAAGTC
GCGGTTTTGT
ATTGGTAGCA
GGCTATTTGA
TITCGCTTCAA
TI'CAAAGAGA
TCAATTTAAT
CGCTAAACGC
CGTTATATCC
AAGAGI'GAA
TTCTGATGCA
TAGGATATAT
TGTTTGCAAT
TAAAAACAAA
TTITI 1TGGATT
CTAACGACAA
TTTATAAAGT
AGAAACAAGG
TGAGACAATC
TCTTGAAAGG
CCCACCACCT
TAAAGGGAGT
AAATATCCTA
GATAGGACAA
AGGGGGACTA
CTATTTTGTA
ATTAAAACTT
AGAAACAAFI'
GGTGCTC1TT
TATTAAAGTT
CGGTGCAGAA
GCAACTCAGA
AGTF1'CATGA
AGCAACTCAC
TTAGGGGAAC
ATAGAAATAG
GCCAAACAGA
GAGCATCTGT
TTTTTAAGAA
CAGTATT
AGATCGAT
GTTTTGAAAA
ATTGGTATAA
GAGAGAATGG
ACGATACAAC
AGAGCAACGA
AAAGAT'ITCA
AA.AAGCTACC
GAATAATGGA
TAGGATTGTG
CTAGCAAAAA
ACTATGCCTT
ATGAACTATA
ACATTTGCTI'
AAAATTTTAT
TATAATATCA
AGAGCACCAT
TCTCTI'AAAT
CGAAGCTTTA
GCAAGAAAA
AGCATACGCT
TATGGGTGGG
CACAGAGCTA
TGGTGTGGGT
TATCTI'AGGA
cATAGGTATG
CAATGGTCTT
120 180 240 300 360 420 480 540 600 660 720 750 INFORMATION FOR SEQ ID NO:1114: SEQUENCE CHARACTERISTICS: LENGTH: 1146 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAIE/KEY: misc-feature LOCATION 1 .1146 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1114
S
S**S
S
SS
S
GGTTACAAAA
GTTTTGTCGG
GAAGAAGTGG
CATGATI'CT
AGAGCTAAAG
AAAGAGACAA
GCCTTAAAAG
AACCAAGAAA
AAAACGAGCA
CTTCAAATGG
TIATCTI'ACA
AAAGAA1'TGG
GCAAAAGATA
TTTAGCATIGG
AACTrGTTGA
AATCAAAAAT
AATTrGATA
GTAGATAGCG
TTTATTTCT
TTTGAA
ACTATAAGAT
CTAATGTGGA
CCGCAAAAGA
TAGAAGACTT
TTCTIITAGA
GAGGTAAAAT
ATAACCCTCT
CATTCACGCA
GTATTrAA
GTGTGTTIC
AGCAAGCGAT
ATAATATAGA
TTGCTCAAAA
CGATI'GATAA
AAAATGTC.AA
TGAGTTTCGC
CCCAATCCAA
ATCCTATGAT
TCAA~AACAGT
GCTTGCAAAA
GCAGTTTGGT
AGACGCTCTT
GGTTTTAGA
TTTAGKA.AAC
CCTTACTGCT
TrATAAGAAA
AGAAGATAAG
AAAAACTACC
TI'TAGATGAA
TGAAGAATAT
TTATTACTTG
AGCCACCAAC
GATCAATGAG
AGATGATGTG
ACAAAAACAA
AAAATCTATA
GAGCGACAAA
GGITI'CTGCA
ATCGTTTA
TCAT'TTTCA
AAAGCTCGCA
AAACAAAAAA
AAGTACAAAA
AAGTCAAAGG
CTTCTT1CCTA
GAGCGTTTGA
GCTACCACTA
GAGCAAAACA
TCCAATAACA
CAGCTTGAAA
ACGCTIATT
AAATACTTAA
GAGTTGAATA
AAATTGTGTT
TTAAAAAAGA
ACAACTATGC
GCTCATTGGT
ACGAGATAAA
AGAAGCTCTI'
TCAAAGAGCT
AAGAAAAAGA
CTTATGGTGA
ACCC'ITATGC
GT1'AT1'ACTA
AAGATAAGGC
AAAAAGCGAG
TTTCTAAT1T
GAAACAAATT
TI'AACTCGGA
GGGGCTATGA
CTITGACTAA
TGTTGGTT
CTAATGAATA
AAAAAGAACA
TGCGITTGGA
AAAAGAACAA
AAACAATACG
TGTGGATI'AC
GGCTCTAGAG
TCTAGAGCAA
TTATGTTTTA
CCCCCAAGTG
TCAGGCTTIG
CCGATTAGCT
ATIGAGCAGA
TGACTCCAAA
ACGCTI'GGCG
AGCTTTTTCT
AAACI'CACC
AGACAGCTC
CAATATCTTC
CTACAAGATA
GAATAACCCC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1146 TACCGGAACA ATGTI'GCCAA INFORMATION FOR SEQ ID N0:1115: SEQUENCE CHARACTERISTICS: LENGTH: 927 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geriomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .927 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:l115
AAATTTAGTG
AAACCAAACG
GTTTCGCATA
AAAGAAGGGT
AAATTACTCA
CGCGTTTTT
TGCCAAAAAC
TACAAAAAT
AGTGCGAAAA
CCTAGCGCAT
AAGGAAATCA
GATGTGATGA
ATCGTAGAAA
CGCATCGGGA
AACTI'GCAAG
AAGTATATTT
CTGGAAAAAG
AGGCTAATGC
ATGAGAGCCA
ACCAGTGCAT
TGGCTITCTGT
CCCATATCT'
TACAAGAGTA
AATCTCAAAA
GGCTTTTTGA
TTAGGGAGAG
'rrGATAAATI'
AAGAAAGCCA
CTAACGCGCG
TGATCGCTCA
TATAATGAAA
CACTCTTTTA
GACTAGAAAA
AATCATTTT
GCTCTCACAG
GCATGATGAT
GGCTTTGAGT
TCAAAAATAT
TTTAAACGCG
AAAGGATTTG
TTTG2TTTGAT
TATAGAAGAA
AAAAAAAATC
ATI'GAAAATG
AAAATCATGG
ACTAACGCAG
AACACTTIAT
TTGATGAAAT
TTAGACACTC
GCTTAAAAG
TTGAAAGGGT
AAGATTGACA
TCATCGCAAT
C'rITIAGAAT
ATGAGCGATG
TTTI'GAGCG
GAACGCATAG
GTGATAGGTA
CAAGAAGTGG
AGTAAGGAAG
GCTTTGTAGC
TAAACGCTCA
GCATCGTGCC
CAGGGCTCCA
CGATGGGCGA
ATGAAGAGTT
CAGCCACGCA
TTTTAGCTCT
GCATCAGTAA
AAAAAATGCG
ATGAAATCCC
ACAAGGTGTA
AAAACGGGGT
GCGAAAAAAA
AAAAAAGCTT
TCTTATAGGC
TTI'AGCCCTT
ITITAAAGAC
TCATCAAGAA
TGCTGAATTG
TITTGAGTT-TG
TAAGCAGGTI
AGTGCCTTTG
GCA TTAAGC
CGATATI'AT
TTATGAAAGC
TGCGCGCATI'
GAATATCAAAi
GGTTTFTA
GCAAAAACTA
GGCTATATCT ATCAAAGGAA TAGGGAT *5S* S S S. S INFORMATION FOR SEQ ID NO:1116: i)SEQUENCE CHARACTERISTICS: LENGTH: 1176 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1176 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1116 ITTCTGTCTC TAAGTCTCAT AGAAAGGGAC TTGAAAACTA TGGCAAAGAT AXFFTAGATA CAGATGAGTT AAACACACTT TATAAGGCAA ATCTI'GCTTA ACGCATGAGC ATTAITTCAA AITTAAAAAA GATGTAGACT ACAAACTCTT ATATGCATG AGCAATGTIC TATAAGCITT GTAGGCGCAC AAGGAGCTAA
SS
S S .SS S
ATTAAAACCT
TGCTAAAAAC
TAATCCTAGC
AAGATTATI'A
TACATACTCT
TACGCCAAAA
GAAGAGCAAG
AAAGATTACA
TTAAGACAAT
AAAAACCTAG
TTAAAGAGTT
AATAAGTGTA
ATAGAATI'AA
GGTAGAAAAG
TGGA'FIAGTG
AAGCAAAAAT
GCCCAAATCA
GCAACACTCA
AGCTCCTTAC
GCTCTTGTGT
ACAAGCTCGC
TGTrTTTTGCA
GTTTATTGA
GAGAATTAGA
TCTTTGATTA
CCTTI'GCTAA
TTTTAAAAAC
TTCTACTl'AT
AACACATTCA
AGAGAAAAGC
ATGATTACAG
CACAAAATTC
AACATTACAA
TTTATCAAGA
TCTCTACTAA
TTGATAGFFI'
ATTTAATGCT
AGTTGTAGCA
AGTCATTAAA
ATGCTTAGTG
TTTGGATAGA
GACCAAAGAA
ACTCTTAGAC
TGTAATACTT
AGTAGAAGAG
TTATAT1'AAA
ACTAAAATAT
?I'TAACGCTT
ACAATATGGC
AACCCAAGAC
GATTTATATT
GATAGAGAAC
AAGTCTAATA
AGAACTCTAA
GGAAAACAAA
AAGAGCAAGA
AAAAGGCGTT
AGCTTACCCA
TATAAGCCAG
GGGGGACTTA
CAAAACTACT
AAGAGTTTGT
T1'CAATGGAG
TATAATTTTA
ACAGGCTTAC
TTAGTITTAA
CATACCACAC
AAGAAG
AGATTGCCCT
TAAAGAATGT
GATACTTGTA
TGGCTALAGTA
ATGGCTTTGA
GACATTTA.A
CTACAAGCTT
GAAAATGCGA
CTATTTTAAT
TAGAACCAAG
CATATCTCTT
TCCCCTTAAT
ATCTATTTAG
CTTCAAGGGC
AAGAGCATAA
AGATAGACAT
CAATATATTA
TGTGTATCTT
TGTGATGTAT
TTTTACGCIT
CGATAAAGAC
TGAAAAACGC
AGTG~rAAAC
TCAAGGTAAA
CTTGAATGCT
TAAAAAGGAT
CTTTAAA'ITA
GCATAGTTTr
GTTAGGGCAT
CAAGAAAGTG
300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1176 INFORMATION FOR SEQ ID NO:1117: SEQUENCE CHARACTERISTICS: LENGTH: 510 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .510 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1117 a aa a a a a. a. a.
a.
a. a
AAAAGAAAGG
GGTTTII'CAC
CAGCTCACTA
TATATGGA
GAAGTCCCCA
GAAAAAITI'C
ATGATACCT
TITAGCATAG
ATTAAAACCA
AACATTGCAT
CTCTTTI'ATT
GCCCTACGGC
AAAACTTAGA
TGCAATTAGT
TF1'GGCTCAA
GGCTAGATAT
CGGAGTTCT
AAGCTAATTC
GAAAAAI'TTA
ACAAGCGGAT
TAAAGGCATT
TAGATGGAAA
TGCTATTTCA
TGCTAAGAGT
ATI'GAACTCT
TGATGAAGAT
ATTTTACGCT
AGGCATTA
ATGACTACCT
TTAATGGITA
GAAATTTTAA
GTTTCTAATC
TITITACTCT
TTTGTGCTT
ATAAGTGACA
GAAAGCTTAT
TTITIAATITC
TTlTITAGG
TGACCGTGCT
TCAAAGAAAT
CAGGATTTGT
ATGTGTGCTT
TTTTAATCGC
CGCCTTTTTA
CATTGAACAA
ACTI'GCTATT
TGCTTTAAAA
CAGCTCCAAA
GCCTTI'AT'
TCTCTTAAT
TCATI'CCAAA
0 INFORMATION FOR SEQ ID- NO:1118: SEQUENCE CHARACTERISTICS: LENGTH: 627 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 627 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1118
AAGTCTCGCA.
TITTTCAGTAG
AAAAGCAAAG
GGGGTGATTA
AACACCCAAG
TCTAATATCC
GTGAATTTGG
AGCAATGAAA
ATAGAAA'FTC
CTI'AAAGATG
GTCTTTI'TCA
ACTTTAGCTA
GAATAGGCAT
CCCTT1'TA?1'
TCATGCTGCT
AAGTCCAAGC
AGCAATAT
TCTCTCAAAA
AGCTTTI'GAA.
TATCGTCTAA
AAATTAAGAG
CTGATI'TCAT
TAATCAAACA
GGCAGAAGAA
TGTCATTATT
TATGGGGAAT
TAATCCTATG
GGTGCI'GGG
TGGCAGACGC
TGAAGTCAAG
AAGCGTGGAA
CCATI'TGAAT
TATCCAA
GAAAAAATTT
CAAGAAAATA
GGAAGCGTGC
AAGGAAGAAT
GCGAACAAGA
CCTTTGTATG
TACC ETAAGG
GTTAAAGACA
GAAGTGGTA
TCGTTITTTGA
GGGAAAACCA
CCGCGCAACA
TAGTGATGCT
CTAAAGAAAA
ATCAAGAAGC
CGAFI'GATGC
CTTCTATF'C!
CGGCGATTAA
CTAACAAAGG
TTGATGGCTT
CTITAACFI'A
ACCCCAAAAA
TTTATTGGTG
CGCTTCTAAA
CAAAGAAGGC
GCCT1TTTGCG
GCTAGAA'ITG
GGACACGATr
CAAAAACAAG
TATTAAAAAT
120 180 240 300 360 420 480 540 600 627 INFORMATION FOR SEQ ID NO:1119: SEQUENCE CHARACTERISTICS: LENGTH: 549 base pairs TYPE: nucleic acid' STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylor.
(ix) FEATURE: NAME/KEY: misc..feature LOCATION .549 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1119
GGAAGCATGA
GAAAAAAAAC
TTCCAAAGAG
ATAGAAATCG
TATAATGGGA
GGTI'TTATGA
CATAAGGGGC
TTAGCGCAAG
TrI'AATATTT AAGCAT1'TA
TGACGGAAAT
CAGGC7TGGG
TGAATGCCAT
CGCACAACCT
GGAATCCGOA
ATTTTACCGC
ATACGGAATT
GGTIGCCTAA
TAGCTFI'ACC
GGAATTAAAG
GGAGAGAATG
GCTCACAAGC
CATITTGCGT
GCGTITITAT
TTaTAACACG
AGGCGAGGGT
AGAATGGAGG
TTATGAAGTG
CTCAI'AAAA
GATTATGCGG
TCGCTCATI'C
AACGATAAGG
CATAAGGCGC
AAGACGCCAG
GAAAGGCTGA
GTTTTCCCTA
ITTGCAAAAG
TAGACACAAG
GTCGTI'GTTA
AAAAGCATT
TGGAAAACAT
AGTI'ATTGCT
GGCATITGCA
TTAAAACTTT
GCAATGAATG
AGCGCGGGAG
CCATTATTTT
TTATAATAAA
GAA.AAGGGAG
CGTGTI'TGAT
TCGTGAGGAA
TTI'GTATGTG
ATCCATGAAA
GCCTAAGGAA
CTCI'GGGCG
120 180 240 300 360 420 480 540 549 INFORMATION FOR SEQ ID NO:1120: SEQUENCE CHARACTERISTICS: LENGTH: 825 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .825 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1120
CCATTTTIGA
GAAGAGAATA
ATTTTGGCGG
TTITTACAAA
GATGAGITI'G
GTGGATAATA
CAAATGGAGA
GAGCCTAT'C
CATAAAAAGC
GCAGCTAAAG
TCTAAAACCA
AACAAAGCCT
ACTAAACGCT
GAAGTCAGCA
AAGGATTI*IT
ATGGGAGTGG
TGCTTITAAT
CCGATAGTGG
AAAGCTTGAA
TTAAAAAACA
TGAAAACAAC
CCATGAGCAC
CTAAAGTAGC
AGCCAAAAGT
ATCTI'ACTAA
TTI'TACAAGA
ACCTCATAGG
AGAAGATGAC
GATGTCAGAA
TACTAAAAAG
GGTGTTITGG
CATGCAAAAA
TATGGATTCT
AGAGAGTGAA
AGAAGAAAAA
TCAAAAAGAA
GCCAAAAGAT
CAAAAAAGAA
AGGGCATAT
GTTTAATCAA
CCCTIATAAG'
TAXACCGGTT
AAAGAAAGAC
GTGTTrTTTGA
AAAAGCACCA
ATAGGCAACA
CCCAAACAAG
AATTCTATGC
CAAGAATCTC
TCTCAGGCTG
AAAGAAGCGC
GCTCGTAAAG
TTGCAAGTGG
TTCCCCCATA
AGCAAGCAAG
GTCATAGAAG
TGAATGAAGT
TCGTGGCCAT
GAGTCGCTCC
CTAAAGATGA
AAGACAAGTT
CCATTCAAAC
AAAAAGAATT
TGGCTAAAAA
ATAAAGATAA
AAGI'TCTAA
GGGTTITTGC
AAATTGAAGA
AAGCCTTAAT
TGCGG
GATCTTAGAA
AGCCATTATC
TAAAGAGACT
GAAAAAAGAC
AGACAAAGTG
CGATCAAGCT
AAAAGCTGTT
AGAAACCCCC
AGCTAAGCAT
GAAAGCTAAT
GCACACGCCC
TAGGGGGGCT
GCATGCCGAT
120 180 240 300 360 420 480 540 600 660 720 780 825 9 *9 9 9* 9*9* 99..
*9 .99 9 INFORMATION FOR SEQ ID NO:1121: SEQUENCE CHARACTERISTICS: LENGTH: 567 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .567 (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1121
TCAAGGCTTC
GTGTTGTI'TG
GTGGTTTTAG
ATTAGTGAAA
GGGCTTGTI'
GTGGATGCTA
GTI'TCCCTCT
GAAGACGTTT
CAAGTGGTGA
ATCGCTFTIT
AAAAAGCCAT
CCACTCGTTG
GCTATGTGTT
CGGATITTGGT
TGATGGTGCT
GCGAAATCAC
CCATIGTAGC
TATCCAGTAT
TCCATrTGGT
CGCAGAAAGA
AATAAAAGA
GTI'GCTAGCC
CATGAAAGAG
TTTATCAGCC
GCTCGCCAGT
'rrGGCTAAAA
CATTTCGGCG
TCCTAAAGAC
GTTTGTGTGT
AAGGCAT
GI'GAGATGT
CCTTTATGCA
TTGTGGCACA
TTAGGTTTAG
TATGAAAGCT
CACACAGAT
XITTCTTGC
ACGCCCCTAT
TCAGCGCTGT
TGGAAAAACT
TTGCCATGTC
TGCTCAGCCA
TGGATITGT
TTGTITCTAA
ITA.ACGCTT
TCAAACGCTA
CGCATAACCC
TAACCGCTGT
GATTIGAAAGA.
GTTAGTGTI'G
TTTAGACACC
GTTCATGGCC
ATTAGACAAG
AAAA'ITAAAG
CATGAGTI'TA
TATTITTTTGG
TACCAATAAC
120 180 240 300 360 420 480 540 567 INFORMATION FOR SEQ ID N0:1122: SEQUENCE CHARACTERISTICS: LENGTH: 711 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .711 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1122
GGTITGAACT
TTTI'ATCATG
TTGGCGTCTC
AGAAATGAAA
TTTTTT1TIAG
ATAGACAAGG
ATCCTTTATG
AAGAGCGCTA
GTCAAACATG
AATAAAGGAT
GAAGCTTTAA
AAACCCAACC
ATAT'GATIT
GCTTCGTGAG
GCTATI'CTGT
CCATGACCAA
CTCTTGGAGT
CGTTAGGGTT
CGCTCTCTAA
rTTCCCCAC
TGGAGAAAAA
CTATTGATAA
AAGAAAAGGC
AAACCCCACC
GGCGTI'ACTI'
TGAAATAGCA
GGCTGTTGGG
TCTCATTGGT
GTTGCTAGGC
TATTTITI'CA
AATGGATTTA
CATGAAAAGC
CCTI'AAAGAC
CGCCAAAGAA
TAAAGATITG
AATCCCAACC
GTGGTAGTGG
GCGACTITGG
AATFI'ATTT
TITTITACTGG
AAGATGITAG
TGT1'TGAAGA.
ATGAAAGACG
GTCGCTAGTA
AACCTI'GAAG
TCTII'TAATA
CCTAAAAACA
CCATCTAATA
TAGCCTITGG
GGATTGTGCT
CAGAGCATT
TGTI'GGCGTC
TC TI'AGCGG
CTIT'T=AGT
CTAACGCCTA
AGATCATGCG
AAATGAGCGA
AGGCTACGGA
TGCTAGAGCC
AAGAACCCCT
GATI'AGGGGG
TGGCGTrI'AT
GTATGATTTA
CATTTGGGTG
TCTAGGCT
GCT'ITCITTC
TTGCAAGAA
CCTIGATGGC
TGAAGTTAAA
TAAGGGCGTA
AAAACACAAT
A
INFORMATION FOR SEQ ID NO:1123: Wi SEQUENCE CHARACTERISTICS: LENGTH: 1185 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1185 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1123 AGCTTATGGG TTGAAAACCC TATATI'ACTA TCACACTCAC AAGTCTATAG CCCCCCAAGA TGCTGGG=rI TTAAAACCCC TAGAAACAGC GCTITI'GCTI' TGGG LiTFTi. CGTGGGGGCG -rG'FF1-r ACTGGTGCGC TTTAAGGCTT TCGCATTCGG ATTTCACTTA ITTATTGCCC T1'AATCAT1'G
GAAA.ACCCCT
TTTGATTGGT
TCITTAGGGC
AGAATGATAG
GATTTAAAG
TTTGACTCAA
CAAAGCAAGC
AACTCCCCTI'
ACATTGCGCG
GTTCAAATCG
mTCTTCAAA
GCTCCCCAFI'
GAAGGCACTT
AATAACGCAT
TACGCAAGGC
TTAAGCCCTA
TITTAGTAGC
ACTT1CAGGCT
TAGTCCCGGA
GGGTTATT
AGGTTGGAAA
ATI'ACCTI'AA
AAAAA.ACCTT
TTAAAACCCA
CTCAAGGCTA
CTGATAAAGT
AACCCCTI'GA
TCAGCGATTT
CCAAACCCGC
GGTI'TAGCCC
GTTATGATAA
GCTTATI'GGG
GTTAGTTTAT
TTTGAGTTT
TAGCTTTTTT
AGCTIGCATT
GCTGCTTGGC
TATGAATTA
TAATATTGAA
GATrGTTTT1'
ACTAGAAGAT
TAGCCTTTAT
GATCTI'AGCC
AAAGCTCTIT
TACATTAGAC
TTATTCAAGC
AAGCATTGAA
AATCATCTTG
CGATATTCTT
GGGGTTI'TAT
TTAGGCTCTA
TCTI'ATAGCG
TTTTTGAGCG
GCGTTGGATT
GTCTCTACAA
AACAACATTC
CCAGAGACCG
TTAAGCGCCA
AACAGCTCGT
CCCTTTGGCG
TTTGGCGAGA
GATTTCACTT
AGCCCTTCAA
CCCACCTTAC
CACAGCGCGA
TTTAGGAAAC
TTTATTTGTT
GTTTTATCCA
TGTFI'AGGGT
CTCAAAATCT
TTCATTTTFT
GAACGCCCCA
TTAAAGAAAT
CTTACCCTAT
AGATCGCCAT
TTTTATTTTC
AGATAATGCC
GCGCTTATTI'
TI'CGCCCCT1
AAGTTTTTAT
AAAGAACGCT
ACTTF1'CAAC
GATCA
GCTCTA'TIT
CCCTTTTGGA
GGATAAXITA
TAAAAAATAC
TAAAATAAGC
AGATTTGAAA
CAAACTCGCT
CGCTTTAGAA
TTTAATAGCG
TAAAAAAAGC
TFI'ACCGGAG
ATACCGCAAC
GA TTGCTAT
CCTAATG.AGC
TTTAAAATAC
TTCTTACATT
240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1185 INFORMATION FOR SEQ ID NO:1124: SEQUENCE CHARACTERISTICS: LENGTH: 648 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 648 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1124
GAAACGATCA
GGCGTGAATT
GGTAAAAGCA
AG'ITTGTTAG
CGCTI'AAAAG
GAAAACTTGC
CAATTAGGCA
CAACGCTTAA
CCCACCGGGA
TGATTAAAGC
TGCGCATTAA
CGCTITTA.AG
AACACCAAGA
TGGGCATCGT
AAGTCGCTTC
TAGCCCACAC
GCATCGCCAG
ATTTAGACAC
GATI'GATATT TCTCATGCTT ACCCAAAGAA AGCCTGGCGA
CCATTTGGCC
TATTTATGCC
TTTTCAATCG
AATCCTAGCC
CCTAAAACAA
AGTGCTITCT
CACTAGCGCT
GTTAGTCTTA
AGAAAAALGAA
ACCATGCTAA
CTAAATTCCA
CATI'ACCTT
AAGCAAGAAA
GGCGTGGGCG
AAAAAACCCC
AATCAAGTCA
GCCACGCATG
TC'TrGATI'A
TTGAAAAACC
TITIAGGCGT
AACCGGATAG
AAAAGCTTTT
TTA.AGGGTTT
TAAATCATTC
AATTGAGCGG
AAATCAT1'AT
TCAGCATGCT
ATGAGCATTT
AGGAAAAA
TC'TTATAAT
GAGCGGGAGC
CGGAACAGTC
GGAATTGCGG
TAGCGCTTTA
CCTTAGAA
CGGCCAGCAA
CGCTGATGAA
GCAAAAT1'AC
AGCCTI'CACT
120 180 240 300 360 420 480 540 600 648 ATTACAGAAA ACGAAGGGGC TGCTCTCAAG TCTATCGCCT INFORMATION FOR SEQ ID NO:1125: SEQUENCE CHARACTERISTICS: LENGTH: 183 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylorl (ix) FEATURE: NAME/KEY: misc-feature LOCATION I. 183 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1125 TCGCTCGCCC CTAAATTAAA AGCGTTTTIT AAGGTAGCGT TATCCTGTA.A GGCGGTGATA AAAATCACAG GCGTAGAGAT TAAAAAATCG TTFFI'GATGC GCTTGAATAA TTCCAAGCTA TTCATI'TCAG GCACTI'GCAC GTCTAAAAGC AAGAGGTTAA AGCGCTCAAC AGAGAGCCFI'
TCA
INFORMATION FOR SEQ ID NO:1126: SEQUENCE CHARACTERISTICS: LENGTH: 900 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylor (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .900 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1126
S.
S S S S *5 S *9 *9 S S
S
S
*5 5
S
5* S 9*
*SS*
S.
S. S 'T1'GCGI'GC
TTGTTCGCTA
AGATCTGACT
TGGCAAGATG
CTCACCCAAC
ATTAGGAATG
GGGGGTTCAG
GCCCCTI'ACG
ATI'GATGTGA
GTCAATATCA
ACTTAITGGG
CCTTCTFI'CA
GGGATGATCA
T7I'AGGGACA
AATGAA.AGCA.
ATAAAAAAGT
AGGATAAAGA
ATTCTGGGCA
AAGAAGTGAA
AAGCTAACCA
CCACAGGTGT
GGCATAGCGA
CTCACAT'GA
TCAAAGGTGG
TCACTAAACC
CTAAGGCTAG
TCAAGTCTTT
ATAAGCATGT
ATAGCCCCTC
ATGGGAITAA
TCTGTTGGCT
CTACACTI'TG
GGTCAATI'G
AAAATACACA
AAGCATTGAA
GGGGGCTATG
TGCGACGCTC
GCTAGACAT
AGGCAGCGTG
TATCCCTAAT
AAACGCTGGG
AGGCAACAAC
GGGTATCCAA
TAGTATTTCA
AGCCTAITAC
TTAACTGCCA
GGCAAGGTI'
GGTI'ATAGCG
GGAAGCCGCA
GAAGCTI'TAC
CCTACTATCC
ATGTTAGI'A
TTCCCTGTI'A
CAATATGGGC
CAATGGGAAA
TTTGCCGCTC
CTCCTCTATA
GCGCAAGCTA
AACTATI'GGC
CAATACTACG
GCTTGA2TI'G
CTACTGCCGG
GGATTACCGC
CGGTGATCTC
AGAATGTCCC
AAATCCGTGG
ATGGTATTCC
CCTFI'CAAGC
CTAACACTTA
ACCAAGCGGC
CCCCTGATAA
ACACTI'ATGT
ACTGGGTTAG
CCAAGAGTCT
TAAAAAGGAT
GCCTAAGAGT
TAACAAAGCG
CGGTCTGCA.A
cTr1'GGAGCG TGTF1'ATATG
CATTGATCGC
TGGGGGTATI'
TGAAAGGATC
AACCGGCGAT
GAGGAGCGGA
AGGCCAAGGC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 TGGATGGGGT CTATGACATC ATITTTCTAT
CGCCCAACCG
INFORMATION FOR SEQ ID NO:1127: SEQUENCE CHARACTERISTICS: LENGTH: 825 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genornic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .825 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1127
GTGTCAATAC
TTGGGGAGCG
GGGGGGITAA
ACGGATAAAA
GCTGATGGCT
AACGCAAGAG
TTAAACGATG
AAAAATGCT
CTGTCAGCAA
GAATATTT
GATTATTIT
A7.AGCTTGTG
GGTAAAGGCG
CTAGGATTAA
TAGTTATAAT
TCAAAAAAGC
TGGCAGAGCA
ATITCACTAG
GTGCAATCTT
AGAGCATTGA
CTGAAAAATG
TAGAATATTA
CIITTATAA
CTAAAGCTI'G
TTGGTGAAGG
AGTTIGAACGA
TGGCAAAGGA
AAGAAGCATG
AGAACCTI'AC
GGTTTTTAGG
AGATCCTAAA.
AGCTA.AGA.AA
AAGAGAGGTT
AAAAGCTCTT
CAAGGACTI'A
CTCTAAATCT
CGATATGATA
CGAGTTAAAT
CGTAACAAAA
TGCTAAAGGG
TGAAAAGCAA
CGATATTCTC
ACTTTTTACA
GTTTTGTGTI'
GAGCTTATAT
TATTTTGAAA
TATTCTAGTG
GAACACACCG
GCAGAGTI'
TGTAAGTTAA
AAGGGTTTGA
AACGGTGGAG
GATTTCAAAA
TGTTACGCTC
ACGACAGAAA
AAAGAACAAA
AAAGGGAGGA
TGGGGGCGTT
1"ITCAGGTAT
AAGCTTGCAA
GTAAAGCCAT
CTACTGCTAA
ATITTAATGT
ATAATGTTGA
AAAAAGATAA
GGTGTI'CTAA.
AAGCTTTGA
TAGCAGCGTT
ACCTTGAAA.A
AACAA
GAGTGTCATG
GTGTTTATGC
AACTATTTAC
ATCAAACGAT
AGCGAGAGAA
AGTTTGTAAA.
A.AACGATCT1'
AGGGTGTATG
AMAAGATCTA
ATTAGGAGOG
ATATTCTGCC
TTATAATGAG
GAGTTGCAAG
120 180 240 300 360 420 480 540 600 660 720 780 825 a S
S.
S S b
S
S. S 9*S* S. 5 4* S S. S S
S
'I'S.
9.
e~ S
S
INORMATION FOR SEQ ID NO:1128: SEQUENCE CHARACTERISTICS: LENGTH: 417 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY misc-feature LOCATION 1.-.417 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1128
ACCCGCAAAT
CTCATTAAAA
AGTATTAAAT
TTTGGCGGGC
ATCAAACGCT
ATCTrGAAC
TCCAAAGATC
CATCAGCATC
GT1'CAGGCAT
ACTTGCTAGA
AGAAGTTT
ACAACCCTAG
TCCAACAAGC
GTAAGCTGGC
CATGTCAGAA
CACGCCAGGC
AAGCGTGGGG
AGATCTAGTG
CTGTCTTI'TA
GGGCGTGGAT
TATI'GAAGGC
AATGAAAC ACCCCCATAG ATTGTCCTAA ACCCCCACAC cTAGTGCTTr TAATGAGCGT CTAGAAAAGT GCTTGAAAGT GAAGTGGATG GGGGCGTGAA GTGGTGGTTT CAGGGAGTTA 'rrACAGAATG TCAGACAACC
GGTGTI'GCAA
GCATGAAGAA
GAATCCGGGC
TAAAGAACTG
TGATAAAAAT
TATTIGAA
TCTI'GCA
120 180 240 300 360 417 INFORMATION FOR SEQ ID NO:11 29 SEQUENCE CHARACTERISTICS: LENGTH: 945 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 945 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1129 0* a a a
AAACTTTTAA
ATITTTGTTI'C
GTGTTTGTGC
GAATGGGTTT
GATGGGGCAA
GATGGCACGA
GTGAGGAITG
TTACAAGATC
ATTGGAAACA
GGGGTTI'AG
GGGCTI'ATCA
ATTGTGCATG
CAACGCCCTT
CTTGTGGTTA
CAAAAAAGCC
CTTAAAGAAA
GAGTTTTACA
AAGCTFI'AAG
GGCCCACTCA
TAACGCTT
AAGATGCACA
TTTTAGGGGC
GGAATTTAGG
TCAAGCAAA
CTTCTTTTTA
ACATCAAAGC
TTGCCACGCC
CTrIAAGCCA
TAGTGTTIAGG
TTGATGGGCA
CCACGACCAC
AGCTGTI'ATG
TAAGATGATT
CTACAATATA
TCATCAAAAC
AGAAGATGAG
ATTGATAAAA
TTTAAGAATG
GTI'TTTGAGC
CAGGATCAAA6
TGCGATCAAT
GTGCGCGGGC
CCTAGGCTCA
AAGCTATA T
GGCGGAATTT
AGCCACCTAC
CAAGCTCTTA
GGGGGAAAGC
AAAAAAGCGG CTAAAA CGCATGAAAG ATTTIAA GCTCTTTTTA AAGAGC GGGTTWGAAA GC'FITA AAAGCI'ACG CGTTIT ACGCATGCTC ACAATA GCGG'I GAAT TGAACG TTAGAAGAGC ATITGG GAAATCGTGA TCGCT CATACGCCCT TI'AACA ACCGCTTATA AT1'TGZ.
TTAACGCCCT TGTGCG TGCTTGAGTT TTTGCG GATITAAAAG CCAACC CAAAAAAATT CAAGGC CCTAACAAAA AA6AGA
CCCC
ACAA
TAGA
TAT
TGG
GGTT
CTTr
,CTTA
fCGC
ATIT
CTCA
:AACC
;ATTA
TTTTTTAAA
GACTATCGGC
GCAGGCTAAA
TGATAGCCTI
T71'AGGAGGC
ATGCTITGGG
GAAAGAJTrC
GGAGGGCCGT
AAAAGCTTTA
TAAAGGCGAT
TCATGGGCCC
TTCITI'AAC!G
TGAAGACGCT
CCTATACATI'
TFI'IAAAGTG
120 180 240 300 360 420 480 540 600 660 720 780 840 900 945 INFORMATION FOR SEQ ID NO:1130: SEQUENCE CHARACTERISTICS: LENGTH: 654 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .654 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1130 CGCTACAATA CCCCCATGCA AAAAAAGAIT ITITTACTAG AAGACGAITA CCTTTTAAGC
GAGAGTATCA
AAAGAGGCTC
GTGCCTGAAA
ACGCCTGTGA
TTAGGGGCGA
AAAAGGT
GCTrI'GAACG
TATTITTAG
GAGCAAGCGA
GGTAAAAAIT
AGGAGTTCT1'
ATGAAAGGCT
TGAATAGCFI'
TTTATCAC
GCGA'FTATTT
TCAATGATGA
TTAAAGGGAA
AGCATAAAGG
TTGATGATTIC
GCATAGAAAC
GGAGCATITA
CTCTGTTGAG
GGAATTATTC
CGCCITrAcAG
GAAAAAGCCT
TCCGATAGAA
AAAGGAAATC
GCAAATCATC
CACCFI'ACGC
GCATAAGGGG
GGCTATGAAG
CGCTTTAACC
AAGCGCATCA
GATAACGCTA
TTTGAI'ITGG
ATCATGCCTA
TTAGCGCCCA
AGCTCTCAAG
ACTTACATTA
GTGGGCTATC
TGTTTTGCGC
TCTTGCTTT
AAAACGAT
CCTTAAAAAA
ACGAATTGGA
ACATTTTTTA
AAACCGCCCA
CGTTAGAAAA
AAGTGTI'GCG
GCTTTAACCC
TTTTAACGGG
AGACGTGCAA
TTTAATCTCT
CGCT'FF1AAT
AGCGCGCATT
CCACCAACAC
ACTTTTAGAA
CAACTTATGG
CAAGCTTTrG
ACTA
120 180 240 300 360 420 480 540 600 654 INFORMATION FOR SEQ ID NO:1131: SEQUENCE CHARACTERISTICS: LENGTH: 1074 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE:- NAME/KEY: misc-feature LOCATION 1 .1074 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1131 a a.
a
TGTGGCGCTA
AGCGGTTATA
GCGTGGGGGC
CTCAAAGAAA
GAAATGTTI'A
AACGACTACC
GTCCAGCAT'
CTAGGGGGTT
GGCATGGAGA
GACTACOCTA
GTGAATGAAG
CTGGTTACAG
ACACAAGGGG
CAAGCAAGCC
AACATGCCAG
TATI'rGTTGT
GTGGCGAACA
GCTAAAGCGT
ATCGCTCAAA
GTAACGAAGC
AGGATTTGGT
AAGCGACTCT
TT.AATAAAAA
CTATTTrAGC
ATTTACTGGC
TGTCGGGTGC
GCGCGAAAGT
AAT1'ACAAAA
CCAATATCAT
CGAGCCAAAC
TAGTCATTGA
ATTCTAACCC
GGATTGTCGC
ATTATFI'AGA
CGCTTGGAGG
TCAATCTGGC
AGGGCGTGGA
GTATGAAAGC
GGTCAAATGC
G'TrTAGTTAT
AATCACTTCT
GCCTATGAGC
TTI'AGAGCAT
GCAAAGGGCT
CTTAAGCCAA
CCACCCTTAT
TCAAGCCTTA
CCCTAAAGTG
TGTGGCT'GC
GGTGTATGTG
TAAAACGAGC
GCATGGCT'G
CT3TGAGCGCT
GTI'CAAATCG
GGTTTTAGT'
GTGGGGGCTA
AAAGAGCCTT
'FIGGATTrAG ATrI'GCACTG
GTGGTGGCTG
GTTAAAGGGT
AAAATCGTCG
ATGGOOCTA
TATCATTTGT
AACGGGGCGG
ATCTI'AAGAA
AGTTAGGGG
GAAGAAAGTI'
TCTACGGCT1'
AAGGGTTTT
TATAACGGCT
CCTI'TAGAAA
CAAAATGCGC
AAATCGTGGA
TAGAGCATGA
CGTATCMAA
AAACCATTGC
GGAGGTTGGC
TTATGGGTAA
TAATTGGAGG
AAGTA6ACGAT
ATGATITAGA
TGGGGCTAGT
GGCATTTAAA
GGTGCATAAG
TGTTGCATTA
ATAGCCATGC
TAACAGCCAA
ATATCACCCA.
'TI'TAAAGGA
GGGCGCGAAT
TTCTAAAACG
ATACCCTTTG
AAGCTI'GTGT
CGGGCCTAAA
TGCGCATrTA
GGGGGTCATG
CGGTGTGGTT
TTTAGAATTA
AGTCTTAAGC
GGGAGCGGTG
ATACATGCAG
AGCCATACGC
TGGCGTGCCG
GAGTGTGCCG
CACTAAAATC
AGAAGGCATC
GCTT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1074 INFORMATION FOR SEQ ID NO:1132; SEQUENCE CHARACTERISTICS: LENGTH: 489 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1 .489 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1132
AAGGGTAAAA
GTGCGTCAAA
ATTAGTGGGG
GGGCFI'AAAG
ACGGAAGAAT
AAAAAAGAAA
GCGTI'ATTAA
AACGATATT
GCCCCCTT
GGGTAAAAAA
ATGCCGTITT
CTAGTGGGGT
AGAGCAACGC
ACGGCAT'1T
AAACACGCTA
AGGGGCTTAT
TAATGCTCTC
CATGCGAGAT
TGAAAAACTG
GGGGAAAAGC
TTCAAACATT
TAGAGAAGAT
TTTTFI'AAAC
TAAACGCTTA
CTTAI'AGAT
TTCAATAACA
GATCTGGAGT
GTCCTTATTG
GAAGTGGAAT
GAGCATGAAC
CAAACAAGCC
TCTAACGACA
GGCTATATCC
TTCAAATCAC
TI'AAAGATGG
CGAGCCTTTT
TGATCGCGCC
CCTTAGTTAT
TATCTA.AAA
GATI'CAGCCA
AA.AATAAAAA
ACGCTTAAAA
CTTGAGCGCG
AGGGGCGTrI' TTrTIAGAC
TAGCGTGATTI
CACGCTCAAA
GAATGAACTC
TAGGCG'ITTA
120 180 240 300 360 420 480 489
S
S
*5
S
*5 S S *5 5 INFORMATION FOR SEQ ID NO:1133: SEQUENCE CHARACTERISTICS: LENGTH: 891 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .891 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1133 0"a 00 0
TCAAATCATA
GTTATAGAAA
AAGCCGGACG
GCGGAI'TAG
AGCGTI
5
ITTA
GCTI'ATGACC
ATAGGGGTT
TTTGGGCATA
CAAAACAAGT
AGCGGAGGCA
GCAGAAAATT
GTI'AAAAAGG
TTTCCTITAG
G
5
FIAAAAAGC
TTAGCCAGCC
AAAGGGTTTT
TCATCAGTCT
CTGGGAGTTA
CCCTAGATAA
GCGAAGAAAA
CCCTAGATIGG
ATGAAAAGGA
AAATAGAATT
TrCATTrrIAT
ATCAAAAGGA.
ACCGCTI'GCG
GCGGAATGTT
CCT TGATGGT GTrTTGCTAGA
CGCATGAAGC
TATGGATI'AC
TTTAGAAAAA
CACTCAG'ITA
GTI'1TTAGAG
AGAAACGCCT
GA;TTCAGTG
TTATAAGGCG
GGTGGTGGCT
AGAAACCATC
I 'T CTTI'G
ATACTCAGGA
TTCCTACCCG
TGAAAAAGCT
TCAAAGCGTA
TCAGATTA
AAACGT1A
GGGTAA
GAAAACAGCA
GAAACTFTrI' GTrACTAAAG
ATGGAGGCGA
CAAAATTTAG
ETAGAAGAAG
GTTTTAGAAA
GGCTTAAAAA
TCTATGGTGG
CAAAAGAAAT
AAAGGGGAAG
GAAAGCTACC
GAAAAACATI'
AAGGCAAGCA
AAGCCCAAGA
GCGGGGATAC
TGAGTTTAGA
AAAACGGCTC
ATITCTI'AGT
T1'GCAAGCCT 'FTrATCGTTA
ATAAGGGTAA
AGGCTTTAGA
CTGATGTCCA
TGCGAXAGCT
CGTTTATIT
ATGAAAAAAG
TAAAGGGAGA
TGCGAACATC
GAITTTAGAA
GCCTATI'AAA
GAkTGTGAA
'ITATTTGATC
AGGCACGATT
TTATGTGGTr CGCTTITrAT
AATCATCGCT
AGGGTTTTI'
TCATGTGTI'G
?TrGAAGTC
TGATAAGGGG
CGAATGCTAT
120 180 240 300 360 420 480 540 600 660 720 780 840 891 INFORMATION FOR SEQ ID NO:1134: SEQUENCE CHARACTERISTICS: LENGTH: 789 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAM~E/KEY: miscfeature LOCATION .789 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1134 ACTTT1AA.
TCCATGAAAA
TCTGGCATGG
ATGCATGCGG
GCGCTCTTGG
T1'GACTACG
GCGCAAGTGG
GATCCCAGAA
AATGTCATCA
AATTCATGGC
AGCAAGAAAG
AAACATTCTA
ACTGCAAAAA
TI'CACTTTC
TTATTTI'TG
AATTTTTTC
ATGGTAATGG
ATATTAATTC
GGTATCAATT
CTCATGCCAA
CTAGTCAAAT
CTTTTGmAGCC
ATAACGGCAT
TTATGGCGAC
CCACITCTTI
GCATTGAAGC
ATT'TGGATAT
GGTATTCTTT
TCAATCTI'G
CGTTTTTITA
TCAAAAACAA
TTTCTTTGAA
TTCTATTAAG
TCTIGGGAAA
GAACATGCTC
CATGAGTIG
ACCGAGCTI'
CCAATTI'TA
GGGCGTGAAA
AGGGTTTAGG
TTAAGAATTA AGCATTATGT TTAGCTCTTA TTATCTCTAT GGGGCGGGTI' ATITGCAAGG
GCCACCAACG
AAACACTTI'G
CTTAAAAACC
CAAGAAATCA
ACTTATGGGG
GGGGCTTITG
GAGGGCATTT
TTCAATGTGG
TTCCCCATGC
CGCGTGTATT
CTACGATCAA
GC'ITACGCCT
CTAACTATAA
ATCGTTTAAC
GGGCTATGGA
GCGGGATACA
TAGTGGAACA
GGGCTCGCFI'
TAAAGAAAAA
CGTGGTATGT
TAAGGAAT'A
GAATGCGGTA
ACAGGCGCAA
AGGCTITGAC
TTATGGGT
TAGCGAAGCG
AAACATTGCC
CGTGATGGTT
ATTGGCCGGC
AGCCCTTGTG
AAGGATCITA
CCCCTACATC
GAATTIACGTG
120 180 240 300 360 420 480 540 600 660 720 780 789 a. a a. a a a. C a INFORMATION FOR SEQ ID NO:1135: SEQUENCE CHARACTERISTICS: LENGTH: 702 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .702 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1135 T'GGATIGACG CTAAAAATAA AGAAGAAGCC ATCATICAAG GCTACACTAT CATTGATCCA AGCACCGT1'A TTGCCACGCA CACCAGCGAA TAGTGAAAA AATACGCTGA. AGATIITATC ACCAAAGATG AAGTGAAATC CCTITTAGAG CGC?1'GGCTA AAGACTATCC TACGATTGTA GAAGAGAGTA AA.AAATCCC CACCGGTGCG ATCCGCTCAG TCTrGCAAGC CTTG TTGCAT
GAAAAAATCC
TTGGTICAAA
ATCACCAACG
AGCGAACAAT
AATGTGGGCG
CAAAAAGGGA
AATCAAATGG
AACTCTAATT
CCATTAAGGA
ACGATGTGAA
CTF=AAATC
TTTTGCTCAA
AATTGCAAAA
TCGCTCCGGT
AGCAGGCTAG
TTGAAGCCT'
CATGCTCACT
TATCTTAACC
TGAAGACGGG
TAAATTGCGA
ACTcAFI'GAA
GATFI'TGATT
GATTGATGTG
AGGCACGATC
ATTTTGGAAA
GAACAAGTGA
CGTTTGAAAT
GAAAATGGCA
GGGGTTI'CTC
GTAGAGCCTA
GTCGTGCTAA
CACATTAACT
CGATTACTGA
GGGCGAGGCT
TTTTAACCTT-
CCTCTAAGAG
AAGAGGCTAT
XITTTAAGAAA
GCCATGCGGA
Tr
TATIGCTCCA
TTCTAGGGTG
TTCTACCGAT
CTTATI'ACTC
GAAAGTCTTG
AGCCCTTTCT
ATTAGATCCT
300 360 420 480 540 600 660 702 INFORMATION FOR SEQ ID NO:1136: SEQUENCE CHARACTERISTICS: LENGTH: 885 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .885 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1136 a a a a a
AAAAAAAAGA
GCTTTAGGGG
CAGTCCCTTA
GAAAAACATT
AAACAAGGCG
CATCAAATCA
TTTGTT1'CCA
TI'GTTFITCTC
AACCCCAAAA
GAGCATI'TAA
GAAGAACGAT
GAAGAAGTTA
ATCCATTTGG
GATTTCATGC
ATAGAACAGG
CCCTAAACAT
ATAACCTCAT
A.AATCCTAGG
TTGAAATCAT
T1-rrTTGGGC
AACGTI'TGAT
TAACCACTCC
A~ATTTATGG
AGATTGAT
AAATCGTIT
ACGC'TTTT1.1-
AAAACCTGAT
CTTACTATIT
CGCCTAATAG
TTCACAAT1'A
CACGCTIAGC
CACTCATTTG
TCCTG,.rrI"'7i
GATGAAGGAT
TTTAGAAAAA
AAATAAAGAA
GCATGTTTTT
CAACCCTTI'C
AAAACTCTI'A
AAAAGACAGA
TTTAGAAAGC
AA.AGAAAAAT
TGGGAATGAG
GGAAAAACCA TGCATGTITGC TTGTCTrrTG CI-FrTAAAAG AAATCGCT1'C CAAACAGCAA AC TTI'AAAAA TCGCCAAGCT ITTAGAATGC GAAAATATCC CTGCTTIA TGACCTTAAA TTTTATGGT TATI'AAAAGC AATTAAAAAA CAAGAT TITTA GAAGT CT TTTATCCCAA ATI'AAAAACG. FrTATCAAAA CCGCCAGGAG GATAACCCTC CATATCCCAT GAGTFITAAAA ACAAGAGAAA ATGATAGGAA TATTTCTW1A AAACCCTTTT GTGTTACGCT TTTAGATT1' GTCGCTCATI' ATCGCGCTAA AACCAGTT1'A GATTTGTATA TAGGGGGGGA TTCGTTTG TATITTTATCT TTFITTATAG GGATAATGAC AA'?TTCCTAA AAGCCCATAA AAGCCATITC CATI'TGGGGC TATTA 120 180 240 300 360 420 480 540 600 660 720 780 840 885 ATfl'AGCCAA AAAATI'CCGC INFORMATION FOR SEQ ID NO:1137: SEQUENCE CHARACTERISTICS: LENGTH: 204 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .204 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1137 AACACACAGC GCCAAACACT CCCCCTAGTC AAGTCCCGCC TACCTAA.AAC AAATGTGTGG AATGGGGTIT ATI'GGCTTCA AAGGCATTTA TTATATI'GAT CCCAATCTTT CAGGACAGAG TCAGCACCTA TACAGCTAAT TI'GT CACACCCCCT AGTCAAAATT AAACAAAACT TACTCAAACA CGGTCAAAGC GGCAACACGC 120 180 204 INFORMATION FOR SEQ ID NO:1138: SEQUENCE CHARACTERISTICS: LENGTH: 4239 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .4239 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1138 a a. *9aa a.
a a a a
ACGCTAATAT
ACAGCAAGCT
GGGGCG'ITAA
GGGCAGTI'G
AACATCACAA
AGTGGGGCTA
TATAGCGATA
ATCATTCAAG
TCGGCTTCCA
CAAAATCCTA
ACAAGCAACA
ACT1'ATAGCC
AGCGAGAATT
ATGATTGAAT
GATAAGATTA
ACTGACAACA
AATGTI'ACAA
GCGCTAGATA
TCAACTTCCC
ACCGGGACAA
CAAAGCGCTA
ATCTI'TAATC
AATGTI'CTrA
ATAGAAAACG
'ITAGGCCAAC
AATGAAATCC
TCCATCATAG
CTTGAATrr
CAATTTTCAG
TAATITTGA
AITI'TAATGG
TTTT'AGGGAA
AATCTGTAAC
ATGGCTATGA
ATAACAACAT
AGAGCATTAA
ACACTATT
CCGGCTATAG
ITAAAGGTCT
CATTTAACCA
TAAAAACGCT
CCAACCAACT
AAATCACCCA
TCAATCAAAC
ACTCTACTAG
GCGCCACTTG
CTTATFI'AGG
TTGGAAGTAG
ATAACT1'AGT TITrGGGTCA
GTCAAATGGC
CTCTAAGCCC
TI'ATAGGTCA
AAAACATTAT
AAAACTACCT
ITATCGGTGG
CGCAAGCCAG
CAGCGCAAGT
TTATGCGCCC
TAATGGGGAT
TrACAACATC
AAAAATCCTT
CCAAACTIGG
AAATGGGGAT
TAATATCGCT
CTATGATTAT
TTTCACCCCT
GCCTTTGAAT
TI'TAGGGATC
AGACAATATC
AGCGCAAAAG
CTr1'AATAAC
CTCTATATGG
TTCTTCTIT
CTACATI!AAC
TAACGCTTIT
GITGAATAAA,
AGAAGGGATT
TATGGAAAAA
TTrGAGTAAG
AAATAACTTA
CAGTCAAAAA
TGCTAAGCAG
GTATATAGAC
"CTGATTTTG
rCATTGAATT
TCTITAACTA
.TrAATI'TAT
TTAAACGCJTC
ITrTATGGCA
TCGTTTATAA.
CTAACCATAG,
CCTGAGCTTT.
AGCGACAATC
AAAGGCTCTC
AGTTTGAATA
CITTCTCAAA
ACTAACATI'A
CAAGCGCTCC
GGGAATCTCG
TITGGGGGCA
AGAAACACTT
GCTGATTTIA
GAAAGCGGAG
GCTAACATAG
GATAAAATCT
ATCAAGCAAG
GAATTACCCG
GATGATTIAT
CTAAGCATII'
TC7TAA.AAA
GCTTCTGAAT
;AGGCAACAC
ETAATAACCT
kGGCTTTAAT ±tTGACATCAA
PAAAAGGGAT
TGAAAATCCA
PICCCTCTCAA
A
1 AGTrAAA
ATAATIACCA.
AAGCAGGCAC
AAACGCCTCA
TCTACAATAA
ATI'CCGCCAC
ATGAAGTGTT
TAGAAACGAT
TTATAGGCGC
ATGGCTATAG
ACTTGGGGCA
AAGCTAAAAG
GGAGCGCGGA
AAGCTCAAGC
TTAATCAGGG
CCGGCGGT
CTAGCTTGCA
TGAATAATAG
TTGGCAATT
GCATGCTAGA
TAAGCTCTAT
;ACTATAT
LACGGCTAAT
3AATGTCAGC rATCTTTGAC
TACTGGCATI'
P.AACGCTACC
TTCTTCTCAA.
TAACCCTAAC
PkGAT1'CTAAG rl'ATTACTTG 1ACCCCAGGC GGGTTrCT
CTTAAAAGAA
GCAACTCTTA
CAACCATI'TG
TACCCAAGAT
CAGCCCTI'GC
ATTATTAGGC
CATTTATATT
TGTAACCIT
CACAGACAAT
GAATTTAGCG
AGGGAACTTr
AGATGAAACC
TGGAGTCATG
TGTTACCCCA
CGATAAAGGG
TTTAGGCGTG
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680
ATTTTAAAGG
AACGACTI'GT
TTGGTGAGTA
CAAGGTTTAG
GGCACTCTFI'
TI'AAGCAATG
TTIGAATI'ITG
AAGTATCAAG
CTAAACGCCA
GGAGAAATFI'
TCTAGCGTAA
GGCACAATCA
GGCACGCTCA
GCTITIAACA
CAAGCGACTT
GGCGATTTGG
ACAGCGACGA
GTGGGTACTT
ATCACAGGAG
GGCAAGCACA
AAAGATGGCG
ATTCTTTATA
CCCACITTTAA
CAAGCTGGGG
CCTTT1ATI'CG
GGAGATATTG
AATATTTTAC
ACTTCAACTI'
TI'CGCTGATG
GTTAAAA.ATA
GGAACTITAT
GGTTATGCCG
AATGTCAATG
TTGAATGAGA
ATCATCAATC
TATGATII'CA
TATTACATTG
AGAGCCAATG
CGGCATTATT
'FrCATTAATT
AGAGATGGTG
TTCAAAACCT
ATTAATA ITA
ATATTACTAA
TGAACGAGTT
ATATCATCAA
GGAGCGTGT
TATCGCCTAG
GCTATGTTT
TCGCCAACAA
GCGCATI'GAT
CTAATGGCTI
GTATCAATT
CCCCCACTAA
TCTCTAATGG
ATCTCAATGA
ACGCCTCTAA
TAAGCACTAA
TGTTTAACCT
TCATGGCCAA
ACACGCTGAT
GCAGTAGCCT
TGGTGATGAC
GTTTAGTI'GT
ATAAAGTGAA
AACAATATAT
GAAATCAAGC
CTCCCTATTA
CTAACACTFI'
AGATCAACAC
TCGCCCGI'C
CGATCCCTAA
ATGTGTGGGC
ATGGTATCAA
CTTATGGGTA
TGGGCGTITA
CTTGGGGATA
AGTCI'ACAG
TGTrAAAGA
GTTTGTCTGG
CTGACCCTAAi
TCAATAA.AAA
CTATGGGGGA
GCAGATACAP
TTTATGTGAP
CCGGAAATA!
ccccccTACA
TTAGGACAA
TAATGFI'ATT
GCCGCCCTCT
AGGCTTGCAT
TGTCAATAAC
GTCTATTATC
TTrGCTTCT
AAGCCTTAAT
AGCCAATTGC
TGAGTCTTTA
GGCTAT1'GAT
AAATGCGACC
CTCTACGGCT
CGCTAGTGGT
CAGTCATTCA
TAATAACCCT
TGATAGCGCT
GGATAATTAC
TGACAACGGC
AGGCTTTAAG
A.ATCGCTGT'
CGCTCAAATT
GATTAAT'GG
TCTAGAGAGC
AGAAGTCATC
CTACACGCAG
TGATTTCT'A
CGCTATGGAT
GACAGGAGT I TGTAGGGTA7
TAGCGGGTTC
TAGCCGAGCG
*CAATAAAACI
ATACGACACI
*TAAAAGCGTI
TTTAAGGGGC
*TAAAAAATCC
6CTCT'ATAI
TAAAATGGTC
CAC1'TTTGC1 TGCGGGCAT7
*TGGTATGCGC
AGCCTGCAAA
GATGTTGTCA
TCTCAAGGCG
TTACAAAACG
GATTTITGGC
AGCTCTTTTA
TTTAATGGCG
AATGGTGTTT
GCGGG 17171A
CCTACAACCA
AGCGTGCACG
'FrGTCTCAAG
TTGCAAGCTA
AATATI'GATG
TTGAATGTCA
GTTAGTCATG
TTGATCCAAT
AAAGCCATT
CTTAAGCTTT
TTAACCTATA
GACTCTCAAA
TCTAATGATC
CAGGGCGTTC
CTCAATAAAA
CACTCCACAA
GCTAACCCTA
CAAATGAGTC
"GAACGCTI'AG
*GTGATTITAA
GGAGGGGCTA
GATAGGTTTA
*CATGCAAACA
TITATCAAAA
TTCATCAACT
*TGGACGACTG
AI'ITTTAAAC
AITATGGATG
GTTCTAACGA
TTTGTGATTG
CGITTTCATCC
7AGCATI'ATCA
CGGGCTAGG'I
TATGCTTT
AAGACATTGG
AAAAGCTAGA
GGITGAGCGG
CGCTCAAAGA
AAAAAGGGTA
GTAACGCTAC
ATAATACGAT
CTAATATCAA
ATAATGTGAG
AAAACAGCTC
CTAATAATTT
TAACAAATAA
ATAATTTAAC
GTAATTTCAC
TGGGGAATTT
CTATTATCAA
TCAACGCTTC
ATTACGGGTA
ATGCGCTCAT
ACGGGCAAGC
ATCAATACAT
CTATCAATAA
AAAGCGTGGA
TCTTTGAAAC
AAGATTIAAC
ATTTTAAAAA
GTTTAGCCAA
AAGCCCTTAA
AATACTCTCA
GTI'TCATTAG
TTAAGGGCGT
TCACTCAATC
GAAGCGAGCT
CCTATGACCC
ACGCTAAAAT
CCCAAGTAGG
ATCCTAIIA
TCAXITTI'GC
CGGATGTGGG
GTAATAACAC
CAGGCGGGGA
'TTGGGCTTGA
TGTGGTAGCG
AACTCAAGGC
CGTI'TATAAT
AAACGATTTA
TTTrAACTT
TGGGGGTAGT
TGACTTTAGC
TATCACCACC
CGTTCAAAAA
TCCTGCAAAC
CACTTCTI'A
TAGCGTTATA
GATCACCAAC
CTTAAACCAA
TAATAGCTAT
TACTCAAGGC
TTCACCAGAA
TAACAACCAA
TGATATTAAT
CGTGAGCGTT
TI'ACACTTCC
CCCACAAGCC
TAGCATCGAT
TAAAGGAAGC
CACGATCGCT
TGACGCCACT
GCTCTCTGAC
AAACAAGCGA
AAGGAATAGA
TGGAGGTACT
GATTGTGGGA
AGGCTCTAGC
AACCATGAGC
CCTACTCTCA
CAPLTIATGGC
CTTAAGCTAT
CAACCAATTC
CCTAGAALAGT
CAGAGACTrA
CCTAAGCTAT
GATAAGAT'G
TTATAAAGAT
1740 1800 1860 1920 1980 2040 2100 2160 2220 2280 2340 2400 2460 252 0 2580 2640 2700 2760 2820 2880 2940 3000 3060 3120 3180 3240 3300 3360 3420 3480 3540 3600 3660 3720 3780 3840 3900 3960 4020 4080 4140 4200 4239 *9 a.
a a a a. a eta.
a a a. p 000 a INFORMATION FOR SEQ ID NO:1139: SEQUENCE CHARACTERISTICS: LENGTH: 579 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .579 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:l139
AGGGATAACA
GAGCATGGGA
ACAGACCCTA
T1'ACTTGCGA
ATGCAACGAA
AATGAAATAG
CTATCGGTI'
GAGAGCGGTI'
TATATTAAAA
TTAGGGGCAC
TGGAGCTTAT
ITTAAGTFI'GA
GGGAG'FITGT
ATAATTGCGC
AAGCTAAAAA
AGGTTI'TAAC
TITAGAGCGCG
TATGGCAAGG
GCTCAAGCAA
TAAAATI'AGG
ITIAGGCTCT
ACAAAAAGCG
CTATITGGCG
TATCGTGGTG
CAAGCGAGAA
TTGCTCTGCA
TPTTAAAGGCG
AAGTGCGGGC
GAA'TTAAGC
GGTTAAACTT
CAATCCAGCG
CTCTATFI'TG
TGCAAGGGGA
GCTGATAGCG
GCCCTTGAAT
TTGATTTCTC
TTTGATTGCA
TGTGTGCGTT
GTGGGGTTGG
TCA'FrATTA
CTAGGGCGAA
ATGAAGAAAG
AATTAGAAAA
TGGTGAGCGT
TITIAAAACG
CTGTGITGGA.
GCGAAATAGA
TAGAGGACTT
GGCTGAATGT
TCTITTTAAA
CCTAAAAACC
AGCTAAAGAG
GGGTAATCGC
CCAAAATGGC
ATGGCTGGAT
AAAATATTI'A
TCATAAGCCT
GGAAGGCTTG
INFORMATION FOR SEQ ID NO:l140: SEQUENCE CHARACTERISTICS: LENGTH: 504 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/ KEY misc-feature LOCATION .504 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1140 9 9.
*9 9.
9 a
AGAATGGCTC
GCTGTITrA
AAAGAACTT
CTTGTGGGCT
TTGAGCGAAA
GTAI'CAATT
GATAACAAAC
TACATCACGC
AGI'TAAAA
TTIT"1"GGTTC AAAGAGTAAG TCTCTGATGC GCATTrTG TAAGCGCCAA ACCCCCGCAA A'ZTTACCCCT AGATAAAGAG T1TTCACAAGT CTITTACTTT CCAAAGTAAT GGTFI"AG GCTT1'GCT AGCCCATGGG AGCTCACI'C CACTTGGGCT CCTTATACCC T~ ATGTTAGAAA CTI'ATGCACT CCCAAAAGCC CTCATTTAAT
GTCTITTTCA
CAGCAAAAAA
GAAGGCAACC
CGCCAAAACC
GATI'TATTCA
AGATTTTT
TGGGCGATAT
TCATTGATI'
ATGATTTT'C
AACCCGCATT
TCACTAAAGC
TAACTTITTT
TAAAAGTGGG
CCATACGCI'
TI'TCCATGTT
AATCCATGCG
CATGCGTT1'
ATTCCAGTAT
GTATGAATTT
AAAT'TATI'A
*e0 0 INFORMATION FOR SEQ ID NO:1141: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 960 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .960 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1141
AATGATGATG
ATGGGAACGC
AAGATAGAAG
TI'GAAAGCCC
CAGCCGCAAA
ATCGTGGTGG
ATTAA TTGC
ATACTCAATG
AGCGGGGATA
TTAAGTTTAA
CATI'CCATCA
AAGGCCGATG
TTTAAATCTT
GTGGAGAATG
CTITGTAGGTT
CCTI'TGAAAG
AGAATAAAGT
CTAGTITI'GC
TGGTGGGGCT
CAGAGACTAA
GTT1GAAAGA
TGGCTTATGG
ATGCGTCGT
ACGATAGGAT
TTTTAGAAAG
AATTAGCGCG
CAAGAAAGCC
GGTTAGTGGG
GGCCAGAAAT
AAAAGAGCCA
GTTTGAAAGG
CGAAGGATTA
AA'IWGAATrA
TGAAGTGATC
ATI'CACTCAA
AACATACATT
GCCTGAAGI'
TAAGATTI'G
ATTGCCCAAA
TIATGGCATA
CGCTTCTTTT
CATGGGGGCG
TCAAGATCAC
TTTAAAGAC
CTTIAGAA
CAAGGAAGGC
CAGCGTGCGT
TT1'GAATGGC AAAACAAGGA ATAACATGCG
TTAAGGGCGT
AGGGACAAAC
TTAGAAAATC
CAAATCTTAA
CCTAAAGAGG
TACAGGGGGG
AGCACCATGC
TTAAGAGAAG
ACTCTGCTI'C
ATGCAGGCTA
GCTAA.AAACT
AATAGCCTTA
GAGATTTTAG
ATAGCAAGGT
AGGCGTTTGA
TGGTTGAAAA
CTFFI'GGGCG
ATI'TAAATAT
AAGGTTTGAA
TITTAACCAT
CTI'CGCCCAT
TTATGGAI'rT
ATTATTTGGA
TT1'CAACGCT
GTTTTTGTAA
TGTTTTTAA
AACTTAGA
CAATTGATGA
TGCAAGCGGT
AAGTGGGCGG
CATCGTATT
TGAAGATAAA
CAAAAAAGAA
TCCCATTTTC
GCCTGATTTI'
CGCTCCTTGC
TCATGAGATG
GGAATTGGAT
TTTAGACGCT
CAAAAATFFI'
AAAAATCGCC
ATCGCTTGCG
AGTGGAGTI'A
AAGAGGCGTT
GGGTAAAAAG
TATI'CTAACA
C
CC..
C
CC..
C. C
C
INF ORMATION FOR SEQ ID NO:1142: SEQUENCE CHARACTERISTICS: LENGTH: 513 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION .513 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1142
AAAAGCACAA
GGCGTGTTGT
ACTAAGACI'
TI'AGATAAAG
TCAGTCGCTC
GTCATTGATC
AA&ATCCCTA
GTGGCGTTAG
ACCATGCTTA
GGAAAACAAT
TAGCGGGAGA
CCACCTACAC
ATGAAAT'AT
AAATCAGCTA
CCAATCTAGT
TCATTAGTAT
CCAT1'ACCGT
AAAAAGTTCC
AATGGAAGCG
GATTAGCT
TTCGCAAGTG
1-2ICCCTrAT
CAACCAGTT
AACCCCCACT
CGCTAAAGAT
GGAGCTGACT
CTGCAAAAGT
CAATrACGAT
GAGGCTAAGA
CGTGGAGGTC
GCTAAAGAGG
AAAAGCGACA
AAAGAAGATG
GAAGTGGGTA
AAATGCGTGG
CC
TTACGGGTGT
TCGTGAGCGG
CCACTAAAGT
GCGAGATI'GA
TTAAAAAAGG
AGGAAAAATA
ACATI'ATCAC
AAGAAAATAT
TGGAGGGCAA
GGGCTATGGC
GGATATFI'TG
TTTCATGCT'
CGGTATCGTT
CCAGCTTTAT
GCAATCTGTG
CGTTCTAGAT
INFORMATION FOR SEQ ID NO:1143: SEQUENCE CHARACTERISTICS: LENGTH: 1284 base pairs TYPE: nucleic acid sTRANDEDNEss: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FE.ATURE: NAME/KEY: misc-feature LOCATION .1284 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1143
GCATGITTAA
TGGGCAGATG
TT1GAAACAAT
CAAAGTTIA
AAATTTGATT
TGCCAGTTTA
CGAGATGGTT
ACTI'ATGTCT
GAGAGTTTGG
ACCACCAACC
GCGTTAAAAT
ATCGCTATTG
TTAAATAAAG
GTGAGTTTCT
GAGTTTTTGC
TATCAAAAAG
GAAGGGGCTG
GATGTGATAG
'ITCAGACAAA
AACGATGTTT
AGGAGTCTI'A
ATCTATGGGA
AACAAGAAAA
ACGCTATGCC
TAGAAGAAGT
TITTAGGATC,
ATTGGTI'TCT
TCTATAAGGA
ATITATTGCA
ATGCTCCCAG
AAA TITTGCG
AACAGGCGTA
GITTAGATAA
TAGATACGAT
AAGTTTTTGG
TACCTTITTC
TAACAAGCCC
ACGTTTCATC
ITGGATATGC
AATGGGTGAA.
TTTATITCT
CTT1'GTI'GTC
GGACAAACAA
AGTI'AAAAAA
TATTACTAAT
TAAAAGTTITA
TITI'CCTAAA
TI'TATGCGTT
TTTAGGAGCG
GATTCACAAA
AAAAATT~T
AATI'TTAAAA
TATTTIAGAA
TGTATATCTC
TTACAGAAAA
TACTITAGGC
GTGCTATGTG
ACACCCTAAA
TGAATACCCT
TI!GTGAAAAA
TI'CATATTTT
TTTCITCATT
TCCAGACGCG
TGTATTTTA
GCAAGAGAGG
GAAA
ACGCAGATAT
GGCATAGCAA
TACAAAACAT
TTTTATAAAA
ATGCAGGCAG
AGAAATATTG
AATATITTAT
AAAGCGGTAT
GGCGAAGAAG
TATAGCAATT
TACTTG'TT
TATTCT1'CGC
GATCTCCTAA
CCCGTTTATT
ATT'ITAAATG
CACCGCTCTA
AAAGAAAGTC
GACAATCCTA
ACGCATAAAA
AAGCC'ITCAC
TTGTFTAAAA
TGCATATCGG
CGCTATTTAG
ITAATCCAAC
ATTATA LTCA
GAATI'GCAC
ATACTTTAGT
ATCCAAATTC
TTITAGAAGT
AAGTTAAAAA
TTGAACATTG
CATCAAATTT
AAGGGTTAAT
GAATrTTAAA
TTCATAATTG
TAGWAATGG
AAGCTTATGA
AAATTTCT1T
GTATTCAAGA
ACGCTCTGCC
AAAGTI'ATAG
TA PIGTCTCT
TGATAATTICT
AAAAAGCGTG
CAGTGTTGCG
AAAACATGAA
CGTTGCTTAT
GTTTG'ITGCG
ATATAAAACT
CGTAGAGGGC
GAAGCAAATC
CCGCCATTTA
AGAAGGAAAT
CCAAAAAGCT
TTATGATI'GC
GGA'FFITATG
CGI'CCAATC
AAAAATAGTA
AGACATTCAT
TCAAGAGCAA
CTTGTTTTGC
CGTATI'AAAA
AATTAAAAAA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1284 a a a a.
a. a.
a.
a a a a. a a.
a INFORMATION FOR SEQ ID NO:1l44: SEQUENCE CHARACTERISTICS: LENGTH: 1125 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geriomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1125 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1144 GGGTTATTAG CTI'GTTT-GCT GGTCTIACTC AATCTAAAGA TITACGCCGAAj TTTGATGTGG
CCTTTAGATA
ATGAGCGTTA
GTGGGTATAG
GATATGGGGA
CAATGGTGGT
ATTTATTATT
TTrTTrrri~
TCCACCGTGC
CCTTCGTGGG
AAAGAAAGCC
CTAGAAGGCT
ATTATAGGGC
ATGTATCACA
TTCCAATTT
GGGATCACGC
TTCATI'GACA
ATGTATTIA
AAAAATI'AG
TTATTGTGGT
GAAGAGAGAA
CGGTGATGTA
GCGT'ITGGCA
GGGGGCATAA
TCFI'GCCTAA
GGAGTI'TGAT
CTGATTGGGT
GGACAGCGAT
CTTTGATCAA
CCA LTCAAGC
ATGTGCATGA
TGACCCCTAG
GGATCATGAC
AAGGGATGAT
CGGTTAAGGC
TTGGXFFI'AT
AGCGTGAGCC
TGTGGcATGG
TACTATTTAT
TATcTTcAAT TrcTATTTCT
TGCGGTCGCT
AGAGAGCGGC
GTrTGTrTAT
ACAAACCCTI'
TAACATGCTT
GITTI'AGTT
CATTAAIAAGC
CGGCGTGCTI'
GCTTTTCAAA
TTTAGGGATT
GTGGAGGGAT
GCTAATCCCT
TA'TITTTGCT
CAATTACGCC
GTGTTATGGG
GTGTCTTTGT
AACCITI'CTA
ATGTAT'CAG
TTTGTCTTIA
CAGCCTATCT
ATTI'GGGCGG
TCTAGCGTGT
TTAACGATGA
TI'AGCCTCAA
GTGAACGCCT
GGGTGGGTAG
AGAGAGATCT
GTGCTFI'ACT
GTGGATCAAT
TATIACAATA
TACAATATCT
ACGCCTATGG
GGGT1'AATAT
GGTATTACAT
TCCCCACCTA
GCAGTAATGA
CGAGTGGGGT
'FTrCTTACAA
GCGGGCACCA
TTTCAGTGGT
GAGGCCAATG
CTTTICTACAT
TAGCCCACT
GCTTCACTT
ATTCAGGAAG
'1TTCGTCCAT
ACGGGAATCT
TAGAGGCGT
TTATGACAAT
CCAGA
GTTTGGGAGC
CGCTACTI'AT
7TTF7GTCGCT TGCGCTcATT
GATTGGCACG
ACTCACTTTG
TTTGATCTAT
GTTGATCTI'G
GCACCAGCTC
GCTTICCACG
CACCGATTGG
GATTGCGAGC
ACTTGTGGAT
GTGGATTGCA
CACFI'ACCAA
TGGGGGTCTI'
CACGGCAGGC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1125 INFORMATION FOR SEQ ID NO:1145: SEQUENCE CHARACTERISTICS: LENGTH: 903 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 903 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1145 a.
a *5*O a. a.
a a a a *5 a S a a. a 9 *9 a
GGTITI'GATG
CTCCAAAAAG
CTCGCTCTCA
ATTGGGGGGT
TCCGTAGGCT
ATGCTAGGAG
TCGCCTGAAT
AGTGGGGCGT
TCCGTAGTGG
TGGCAITIT'
ATAGCCATGT
AGCGCGGCT'
TATITGATCG
T1GCGGTTGTG
GCCCCGCAAT
TTT
ACGATATGGA
ACACT'FIAAA
FTITTGGGCA
ATATGGCGAT
CTAAAGCCAT
CGATCAT'GC
TITATTAACGA
TATGGTI'GCA
GAGGGATTAT
TATCCGGCAT
'TTTrAAT
TAA.AGGTCGT
TGAAGGTI7T
TCCTTGCGCT
TAGAAAATAG
AA ITAGAAAC
GATCGCTCTC
GGCTAATTCT
GAATATTGGC
TAGCATGGGT
TGGGGGGGAA
TGCGCATGT'
TGTAGCCACT
GGGGGCTGGA
TGTGGCTAGT
GCTCATTrAAA
GCCT'ATT'G
AAAACGCCTC
CCACGAAAGC
ATCAAAGAGT
GCTCTTTGT
AAGGGATTGT
GCGAACGATG
GGGGCGATT
GTGGTTTCTA
TTCATI'AATG
F1'AATAGGCG
ATGGCAGCAG
TGGGTAATCT
AAGACTATCG
GTGGCGTTGA
TATGCGGTGG
ATCCTI'ITrA
GTCAATGAGC
TI'GAAAAAGC
TCCTCATTGG
TGCTCATCTT
TGTCTAATAA
TGATCGCTOC
CGATI'AAGGG
TCATGTTGGC
CTCCCGTTTC
CTGGAATGTC
CGCCTTTAAT
CTTATAAAGA
TGAGC ITAGC
GTITI'GAAAT
AAAGATTIGT
TI
5
TIAATGT
TTCCAAAAAA
CGCCGCTTTG
TGCGGCCGTG
TGTCGGCCCG
GGTGTGAA
CCGTATCGTI'
TAGCCTI'TG
CACTI'CGCAC
TGCTATCAAT
GGGGGCTIG
AGATAAAAAG
CTITAGCTGG
CCAGCTCGCT
G?1'AAAAAAA
CCCTTTGAT'
120 180 240 300 360 420 480 540 600 660 720 780 840 900 903 INFORMATION FOR SEQ ID NO:1146: SEQUENCE CHARACTERISTICS: LENGTH: 1296 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1296 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1146
AGAATGAAGC
AACACGAATG
GAAAAATACG
AAAAACTACT
ACCACAGCGA
GGCACAAGAG
ACTCTFFI'AG
ATTATGGAGG
CTI'AAAATTC
TACAGGGACG
GAAACAAACG
CATTTGAATG
CACGATTITAA
CGTTACAACC
CCTTTAGAAA
ATTGTACATT
CAAGTI-FTrG
AGGGATAAAA
ATCTTAACTT
AAAGGCATCA
AACGCTTTAG
AACATTCAAA
TI'AAAAAAAC
AAGTTITAGA
CCCCTTIAAT
TI'GATTTTAA
GCTI'GATGTA
GGITTF1AT
AGCTI'TATAG
TGAGCTCCCA
TCACCAATAT
CTAAAAACAG
CCCTI"TI'AA
TI'CAAGCCTI'
GAGATCCCAA
TITATAATAT
CGATCGCACC
CTAAACCTT
AAAGCTITAA
CCAAGCGCCC
CAGACAATCC
ATAATICTTC
AAAATTTAAA
TCTTTAAAGA
CCTGACTI'AT
AAACCCTAAA
CGCAGAAAAA
GATTAAGATT
TTCCTTGCTC
CGACGACAAA
CGATTTGGAA
TGCGATTGTC
CACAAGCGAT
CTTTTTTAAA
CCCCATTAAC
TITCGCTCAAC
TCTTAAAGAA
TTTAGCGGGC
GTTATTGGAA
AGTGGTCGTG
AAATCAAAAG
TAAAATGGGA
TAGAAGCGAA
TAAAGTCATI'
AGACGATGAG
CAAAACGATT
CAACACCACG
GAAATCCTTT
AACCTGGCTA
GTAGGGATTA
TrAGATTTGA
CACATCAAAG
GAAGCGATTC
CAAAAACGCA
CATTTAGATT
GATGAGGGCT
GCGCGCACTIT
CCI'CCATTA
ACCGCCCTGA
GTTITAGGGG
AACTTTTATG
GATTTTGCCC
ATCACCGCTC
GCGATAGCGA
AACGAAGAAG
GTAGAAAAAG
GTGTTGTTGA.
TTTTTT
CCTATTCITTT
TTGTCAAAAC
TTTTGGATT
CAGGCACTAA
ATAAAAAGAC
AAAAGGGCT
GTITAAAATG
TCGCTGGGCT
TCCATCAAAA
TAAAAGTCAT
ACGCACTGGA
GCGCGTC'TIT
TCCATI'CCCC
TTAAATT1GCT
GGGTTAAGGG
ACACAACAGA
TTTTT'GGGGC
GTTGTIACGC
ACATCATIAA
TAAGCGAT
GCCTTI'AAAC
TAACGAGCFIT
TGGTAAAACG
CGCTCTTI'A
GACCACGCCC
CGAATACTI'C
TGATTTCGCT
TATAGAAAAT
CAACAGAGAT
TAAAAAAGCG
ATGCTACCAA
CCTI'TTAGGG
CACTCAATI'G
GCGTITGGAA
CGGCATGCAA
AGGGGGCGAT
GCATCAAATC
GGATATF1'TA 120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1296 too* 0 0 *.0 6* ACCGAAAAAA GGCCATITTA TTTTAGGCAA GGGCGATGAA INFORMATION FOR SEQ ID NO:1147: SEQUENCE CHARACTERISTICS: LENGTH: 981 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION l...981 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1147
AGATI'ATTAT
TTATAGAAA
TGCGGGGCGA
CAAGATGAAA
cTAAAGGATA
AACGGCTACA
GATGAAGCCA
GCGAGTGAA
GTAACTTI'AG
GCACGAAAAA
CTAGTGCCAC
CAAATCAACC
TcTAATCIT ACAGCCC CCC
CCTTTAAAAA
TTAGAAAACA
GAAAAC'FF
CTCAA TTI'AA AACAAGGATA GGGATTTTr AGAAAACGAT CGAGTAACCC TAGTTTGTTT TCGCTAAACT
CAAAGGCAA
TZ'TTACAAGC CTCTAGCGCG TCAGCCTAGA AATTGACCCC AGCGGT1'AFI CAAAACATTA GCGCTI'TTGA
AGTCAI'AGC
TCTTTTCGCC TAAAATTGCC GAGCGGTCAT TAGCGTG TT AAAATT1'GCA AGCTCAAAGT, AGCATGCTAA
TAAGCTAATA
TAGCTAAAGA TTACTACATT TAGACGCCCT AAACGCTI'AT TCACAGAAAT TGAAGCGTI'C CCGCCCAAAA ACTCCTI'AAA TAAGCAGTI' T
AACATGCAAG
TTTTTAAAGC
TGCGAAGCGA
AAAGCTAAAG
TrAATGCCTT TT1AGAAG
AACCGCCCCA
GCTCTGGCTC
GGTGAAATCG
GTCTCACGAT
GGGATCATGA
AGCACCCTIT
AAAGCGCTGT
TTGCTTGACC
AAAAAAGAAT
GAAGGCTI'GA
AA'ITCAGTT
TCATCAATAA
TCACAAAAAG
AAATTTATGA
TGTATGAAAA
ACGATGCGAT
ATGTGATGAT
AAGCCTCTAT
CTCAAATCTT
TTGACAAAGA
ACGCTACCGA
TTGCATCCAC
GTTTTAAAAA
CAAACACCGA
TAAAAACGCA
TAGCGTTCAA
GTGGTGCGAT
GGGGGCTAI'
CGCGTTI'TAT
AACTCTGGCA
AGACCCTAAC
TAAAAGCA1'
TAAAGTCCCG
CCCCATTAAT
AGCCAAAGAA
AATAGACCCA
GTGTTA'FIAT
CGGCGTTAA
CTCTATCAAC
GTGTCAAACC
CAATATTGAT
ACAATCCTT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 981 St..
S. S 5*5* INFORMATION FOR SEQ ID N0:1148: SEQUENCE CHARACTERISTICS: LENGTH: 1074 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY misc-feature LOCATION .1074 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1148 GGG TTT AAAG TGCGTTTG'T *see
GTGCTITI'AG
ATGCCTGATT
AATITACACCT
AAATCCAACC
CCTA7TTTT~
TTTGTGTATA
TCAGAGCATT
TTATTGCAAA
TATGCTGAAG
ATCTATGAGA
GAAACCT1'A
AAGCCTGCGG
GCGGACACGA
CCGTTFAA
GCTCTT'ITAG
'FTAGGGAAGT
T1'CGTATTTC
CTTTGGAA.TT
CTGCGAACAT
TGCCCATITC
AATACACCGC
TGATTAGCCT
TGGAAGAAAA
TGTTAGTGAA
AAGCCCAAAA
CTAAAGAAGC
TGCCCTTGAG
A.AACGCTCAA
TI'TCTATCAC
AAAAAGTGCG
GCGTTAAT
GGCTAAAGT'
TCAGCATI'C
TAGCTCTCAG
TAGATTTGTG
GTTFTGTA
GATCATrTTTA
CTTGCTTTTA
CCTGCTCTCT
GTITI'CACG
AACGCAAAAT
ATACAACGAT
TATCAAGGTT
TTTTITGAA
TTrGAACTG
AAATTTCCGC
AGACGCTC'T
CTCGTTTTTG
CGCTTATTT
TATCATTATC
AGGGATACTC
TCTTI'GGTAT
GGGTGGTATT A T1TTCAAATA CTrITAATC
GGCATI'GACA
ITTTTTCACCT
GCGATGGTT
ATTGGATTr1'
GCTGTITATG
TTAATTTATA
GAITACGTGT
TTCGCCTA.A
GACAAATATI'
GGCGCGAACG
CCTAAAGTIT
TTATCCTTGC
TATGTGTTTG
TCGCCCAGTC
ACGCTCGTTG
ATTCCTGAAA
TTTAAAAAAC
GCCTGAAATA CGCCGATAAA ATGATATTTT ATTCGCTCTC
TATI'TTATAT
CCAAATGCCA
TGGGGTTGAA
AAGACAATTC
ATTFI'GATAA
AAGATAAAAC
GGATTTTACA
CTTTAAACAC
TAGACACCAT
ATGCIT1'AGT
CGATTTTGCC
TCGCCCGCTA
TI'TGGGGGCT
TAGGCGTI'CT
TTAATAAGAG
CACCTrCAT1' GA'TrTAAGC
CGCGACTCCT
TI'TGAGCGT
GATTAATCCC
TTTAGAATCT
TGACACTACT
CACGCATTTA
TTATCAAAAC
GCGCCAAAAC
CTITTI'TGTG
TGAAAACCTG
ATI'CT1TGCT
ATCGCCCTT
AT1'G 120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1074 INFORMAITION FOR SEQ ID NO: 1149: SEQUENCE CHARACTERISTICS: LENGTH: 1377 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1377 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1149 9.
*9t* 9 *9
AAGAGAAGAG
ATCGCTCAAA
AAAACGCTCA
A7AAAAGCCC
GTCATGCAC
CAGCGCAACT
GATACGCCTT
AACCATAAAA
AATGCGCAA.C
GAGAAAAACC
AAACAAAGCG
ATGCCTTTAC
CGTAAAATAA
CTTGTAGGGC
TCTAGAATGC
GGGGCTFI'GG
ATI'GACGCTA
GTGGATACGA
ATAGATGGGG
GACATGAAAG
AAATTAGATG
CCTATCAGTT
GAGTATTTAG
TGGTGA.AATT
GCCACCATGG
CTTCTTCTGG,
CCCTCATTCC
TI'TCAAGCAC
ATACTTTTC
TAGAGGCTAA
AAGAAAGAGA
TAAGTAAAAT
CTAATTCTGT
GCATGAAATC
GCATGCGGGA
TCCTGTGTCG
C.AACAGGCGT
TGGCTAAAAA
AGCAATTGAG
AGGATTI'GC
CAGGGCATTC
GTTATAATAT
ATATTTATGA
AGAGTAGGGG
ATCTrTCTGT
TGGATTGCAT
CTATACTTIAT
GGTGGATACG
GCTTI'ATGAA
AGAGAGTTI'G
CGTAGAAGAA
AAAAAATAAG
TAAGCAAGAC
AAAAAGAGAA
CAGAGACAGC
CAATATCCCT
CAGTCATITA
AAATTCCGTA
CCCTGAAGAT
GGGGAAAACG
ATACAAGGTG
TGGTATGCT
TAAAGAAAT1'
GCAATACGAT
TGATGTATCC
'ITCTFI'TGGG
GTI'AGGGAAT
CGGCCAAGAA
GCTAGATGGC
AGTGGGGAAA
CTGGTGTTTA
ATCGTI'GTGG
TATGATGAAG
ATGCGCAAAC
ACTC LTTTAG ,GCCT1'GTrGC
GTCAAACAAG
TTAAAACTCA
CAAGAA'TI'G
GATGAAATCA
ACGATCAAGC
TTGAATTTGA
ACGACTTTGG
GGCAT1'ATCA
AATAAAATGA
CGGCCGCTGA
AAACCCAAGA
CGGTTGAAGA
AATTGAATGA
TCGCCGGGGT
AAAAAGACGC
AAGCCTTAAA
AAGAAGAAAT
TI'CAAAACAT
CCGAAATTTA
TGCAATTAAG
GCTATTITAG
GGCAAAAACG
CTAAAI'AGC
CTTI'AGACAA
AAATGAGTAT
AGCTTFIAAAG
AATCCGTAAA
AGAAGAAAAC
AGAAGACGTG
TTCATCTAAC
TCCATTAGAG
AGATGAAGCC
TAAAGATAT'
GTrTI'GGGAT
CAAACTACCC
CCTGGAATTG
AGAAGTGTTG
CATTTTAATG
CGCACGCTAT
TTATCGCATT
AGAAGCGGTG
TTTTATTA
GAAAGAGT
TAAGTATGAA
AATC'TTACG
AAGCCAAAAG
GGCTACTAAT
ACAAGCA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1377 GAAGCTTrGG AATACTGCGA AAGGAAAAAA TTGCCGGTrT TTAGTGCTTr CGGTTA.CCAC GTGTIAGGGA TTGACACTT TTGTI'?rCTT TAGTGCATGA GTGCCTATGG ATTTGAAAGT TFI'AGTAACC CTAATAAGGA INFORMATION FOR SEQ ID NO:1150: SEQUENCE CHARACTERISTICS: LENGTH: 1065 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/ KEY misc-feature LOCATION .1065 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:11S0 0 *0 0 o 0* 0
ATCATGGCTG
AATGTGGATA
TATGATTTCA
CATGATAAAA
GAAATCCAGC
AGCCCTACGA
ATTAATCCTA
TATGATCAAA
CAGGTGATGC
GACGCTAAAG
ATGGTGGT
GTGATTI'CCA
ACGAACTCCA
GATATGATGG
GTGGGGGATA
AAGAAAAAC
AAAGAAGTGG
CAGCGCAGAG
ATAT'FITAAG
TTCAAAATGT
AGCGCCCTAA
TGGCTAGGAA
TI'CATAGCGT
GTTTTAATGT
GCATCGCTT
ACAGGGAGTT
AAATTAAA
AATCCAGCGC
TAGAGA'ITAT
TTGAGAGCAT
AAAAGAGCCG
TGTTTTTGGG
CTATCCGGT'
GFI'ATTTAGC
TTI'ATAGCGA.
GCAAAGTGGG
CCAAGAAGAA
CCAAAAAAAA
TCGTGTGAGT
TCTITCCAGT
GGATCAAATG
CTITTCCATG
CCCTATGATI'
TAGCGATATT
AGAAGTGtGG
GAATGTGGTC
CATTGGGCAT
TCTITCTAAA
TAATAAGGAA
CGCGGTGGAA
GAATAAAGTC
GAGCGTGGGG
AAAAGAACGC
CGATATI'ATG
ATI'GATGCGC
GATATI'ATCC
AAGGAGCAAT
CAAGTCTCTT
ACTTATGGCG
AAGCCTATGG
GACAGACTAT
GAATTGAATI
TCGCCTGTGG
CAAATCGTCG
AGCCGTGGGA
ATGGGGAGTA
TTGCAAGCAC
'ITGAGTTTGA
GCTAACGATG
TITCAAGGGT
ACTAAAGAAA
AAGATAGAAG
TITI'AGAAGT
CCCAACGCAG
TGCGCTCTTT
CTATCATGCG
AATTITI'GAT
GGGGAACGGG
TAGGGGGTAA
TATIGGATAC
TGGAGATGTA
CTCAAAATGA
TGATGAATAT
GGGATTI'CAT
TATI'GAGCGG
AAGAAATGTT
AAGTGAGCGT
ATAGGAAAAC
TTTAGAAAT
AAGAG
CGTTGATGAG
CGTAACCCTC
TAGGAGCATC
T1'CTATTGTA
GAGTTTGCCT
GGTI'2TAGAG
GGGGAGCGCG
GATTTTACGC
TCCTACCATT
AATI'TCTATC
TTGTTACCCG
GCTTICAGAA
GGTGAGCGTG
GGATI'TAGAT
GTATGTACAT
CAFI'CAAATT
GCTAGAAGAA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1065 INFORMATION FOR SEQ ID NO:1151: SEQUENCE CHARACTERISTICS: LENGTH: 891 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) AN'TI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .891 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:115l
GGAACAAGCA
AAAAG ITTT
GGCGTCGGGA
AAGGTAGGGG
AAAACCCATA
TGCGAGAITG
TACATCAGCG
TTAGATTATA
AATGCGAGCG
TATGCATGCA
GTAGCCCAAC
AATATCGCTT
CGCTATGTGA
TCCAITGACC
CCAAAAGAAG
TGAGTAATCA
F1GATAATAA
AATCCAACAT
TATITGATGC
AAAATATCTT
AACCCGGGCT
GCGCGGAAGC
TTGTGATTGA
ATTGCGTGGT
TI'AAAATCAA
CTAAAGAAGG
CATTAGATT
GGGAGCGAAA
AGATAGCGAG
GTTIAAAAAG
AGCGAGCCAT
GGGGAATACC
TAGCGCTAAT
GGATATI'GGT
GCATGCCT1'A
TTGCTTAATC
T1'GGATCGA
TACGGGTGCT
GATTGTTACC
CTCCAAGAAT
CAGGGCGACT
GCACTATTTA
GAT1TI'GAGG
CCTI'TTAGTT
CTI'TTTTAAA
TTGGATAAT'
AAATTCATCG
TTAGCTTACT
TTAGCGAATT
AAAGGCGAAG
CCTGGGGATA
TI'CGTAGATG
GGGATT1GGGG
ACACCCGATC
AAAGATGAAT
TATGAAAGGC
GGGGCGAT'G
AAAATAGCCC
TCTAAACTAG
AGGCTTTTGA
TTATGAACGC
CTATCACAAG
CTTrATACAA
TAGATGTCAT
CCAAATTGCA
GCGGCGAAGA
AAGAGGGGGT
CCACTACGCA
CTTCAGCGAT
TG'ITCCT1'AT
TATTCAAGGT
AAAACAGCTC
CTAACGATTr
AAACCGGCAC
AGTATrGGG
TAAAAATCCC
CGGTAAGGGG
GAAAGGTTAT
TITTGGGGTG
AGAAATCATT
AATTTTAAAA
TITAAGCTCT
AGCGTTTTrG
TACCGATGCG
CGCTAACATG
GGCTAAAAAC
CTTA?1'GAAA
GTI'TTCGCAA
'ITTAGAAATA
G
120 180 240 300 360 420 480 540 600 660 720 780 840 891 INFORMATION FOR SEQ ID NO:1152: SEQUENCE CHARACTERISTICS: LENGTH: 1593 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1593 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1152 .0 0 0 0*00 0 00 0 0000 00 0 00 0 *0 0**0 0 0*0 0 0
ATI'TCGGAGT
AAAAAAGCTT
AACAATAAAC
TTGTTATTAG
AAAGACATTA
CAAGAGTATT
GTAGAGTCTA
CCCTTTTATA
ITACCTGG'rr CAGTTTAA~c
GACGCCGATG
GGCGCGCAGA
TGCGAACGCT
GGCACAGAGC
TACGCCAGGG
TATGTCGCAT
AGCAAAAAAG
GAGGGAGAAA
ATcAAGCCCC
TATGAAAAGA
GAATACCAAT
TATGG~i-n-T
GATGCAGGGA
T
rTCCAAGGGG GTTrTAGAT
TACGCTGAGT
GCTCATAAAA
?I'AACCACCG
ATCAAATTC
ATGTrACAGA
AACAAATCTT
CCATTTTGTG
TGAGCGCAAT
AAATCATIAA
AACACAGTGT
TTAACCCTAA
TITTATGAAGA
GATITITAGA
TCATGACCAT
TGGGcAATCC
TTGCGCGCCT
CTrTAGACAA TCACTAGGGc
AAAGCAAAAA
TCGCGCCGGT
ATGCCTATGG
ATAACGACCA
ACGCTTACAA
ATGGTrI'GGA
TACAAGCCCT
TI'GTGTCTAG
ATAAAAGCTC
'1TTGCGAAC
GACTGCTTGA
CAGTGCGCCT
ACCCACCGCT
GGGCTATGT1'
ACAAGAAGCT
CGCCACCAAT
TCGCCCAAGC
GAACGCTTA
TTTAAAACTC
AAAAGAGAGC
GCCTGCGCAA
AAAATTAGAG
TCATAAATCT
TAAITCAAGC
TTATI'ACAGA
AGAAGAAGCG
TGAGTTAGGG
CAAAAAAATG
TATTT'CTCCT
CGAGCAAGTC
GGAAGCcATC
CATTCCTAAA
TTACCAAGCG
TTrAAAAAT GATTGATGTr
TCAAAATTAC
TCAAGCCCCC
AAAATITATGG
TTAATCATTA
TACTI'GGAGC
AAAGTCTCTT
CAAAACCTFI'
AAGGACGCTr
ACGGAATCTA
GAATACGCTI'
GCTGGATACT
GTGGCAAGCT
AGCTGTTTGG
GCTAAAGAGA
AAAGGCATGc
CATGCCAATC
ATGAAAAATC
GCTAAAGATC
CTGATTGTCG
CACGAACAAT
CAAAAAGAGc*
CAAGAAATAG
AAITTTGGTA
CAAAGCGTTT
TI'AGAAGA)A
CATGCCTTAA
TTATTGTGGG
CAGCAAAGCC
CATTTTAAGA
GTT
ATTATGTGAA TACCATTTT
AAAAATACCC
TAGTGGCTGA
TAGAACATCG
TAGAAATCAA
GCGCGAAAJTT
TAGCGGAAGA
TGCATGATGA
?I'GTGTGGAA
AA'ITAGCGOT
TCGCTCT
AATTCCCTTA
AACTCCTTGA
GTGAGGTGGT
ACGAAGAAAT
TGGCCAAAGA
TGGAACTCGC
CTTAATGAC
AAGAAGAGTC
TCGCCTI'GCA
TAAAAC'ITCC
TGAAAAAGAA
TATrGATCCT
AAATTATTTG
GTCTCAATTG
ACCTTIACAAG
TGTGATCGCT
AATTATGGAG
TGGGTGCGAA
CAATCCAAAA
TGTGATTGTG
AGAATATGAC
GGATAAAGAT
TAATGTGTAT
CAAGAAAGAA
ACCT1TTAGAA
AAGCGTTGTC
AGATAGCGAT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1593 TAGAATATTr
AAACTACCAC
GTTrAGAGCT TTTTGAAAAC AGC TGAACGC GGCTTTTTI'A ATAGAGGCA AAATrTGTAT ATAAAGCGCA AGTGTCTCAT TACAAGCGGG CATTATTTAC INFORMATION FOR SEQ ID NO:1153: Wi SEQUENCE CHARACTERISTICS: LENGTH: 759 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (i)MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SEMSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .759 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:11S3.
99..
9 9 9 9999 9.
9. 9.
9 9 9 9 9 .9 9 *996 9* .9 9 99.9 9 99 9 9 9
TTATCAACCG
GAGCGATCAC
ATCACCAGTI'
AGAAATGGGG
CTCAATTCTT
GCCGCTTACC
CAAGGGGGCT
TACATGGGGG
GAGTTTGGCT
GGGGTGTTAA
TTTAAAACCC
AAAGATI'ATG
TTACAGATTG
CTIATCAGGC
CATCTI'CACC
CITTTCACCCT
TTATCTTTAG
GGAACGGGTI'
ACCATTTGCA
ATATCTITAG
GCGTAACCAC
TGTGGCTTGG
AAGCGGCTAA
CAACTAGGGG
GCGTTGTAGG
AATGGATTTC
GGTAGAACTC
AGAAATAAAA
TGATGTGAGC
TTCCTATGCG
AGGCGGGAAT
AAAATATI'TA
GTATAACACC
GGTGAGAGGC
AGGCGATGGG
AATGCGTTTA
GAGI'TCTTC
GGCTGGGTI'
GCCCATGGGG
CATTGGTTCC
GGTAI'TGGG
TATGACAACA
ACAATGTCTG
GTCCGTAACA
TI'GATAGATT
GATGAI'ACT
TTTAGGAACG
ATTTTACCG
GCGTGGTTT
TATAACGCTC
GAAAGGGCGA
CCTTGGTGT
TGAAAGCTGT
ATAGGGATTA
CCGATGAITA
GTITGCCAAG
CCAAAGTTTA
TGATCGCTCG
TGCCCTTAAA
GCTCAATCAC
CTTCTACTGA
TTGACTTTGG
CCACCACGAC
CTTGGAGGGC
TCTAGTCCTG
CCACACGCCT
TTA
9 TrTCCCT
CTCTGGCACG
TGGTAAATI'C
TTTTAAAACG
CTCCACTTTC
ACCTAAAGAT
ATTGAGCTAT
TTTCTTAACC
GGCGAATTT
TTCTACAGGC
INFORMATION FOR SEQ ID NO:1l54: SEQUENCE CHARACTERISTICS: LENGTH: 258 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANT I-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION l...,258 (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1154
GCGAGGATCA
GTGTGTTTGA
GGTTGTIATr
AGTTTGAAAT
GATGAATGGG
TGCITGATAA ACGCATTAAA ACGCTITI' AC TITTTTGG GCGTGAGTTI' TACCAATAAG CCTCATrI'GT GTTITGGTT TAG'TrATGA GTGGCAAAAG AAACAAAAAA AAGATFI'CA TTGACAGCGT TAGCGAAI'A GAAAAGGATI' TGAACATGGA
ATACCCAT
TCTI'AATATG
TITAGTGTTA
AAGCGCTAAA
AGTAACTAAT
INF ORMATION FOR SEQ ID NO:1155: SEQUENCE CHARACTERISTICS: LENGTH: 816 base pairs TYPE: nucleic acid STR.ANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .816 Jxi) SEQUENCE DESCRIPTION: SEQ ID NO:1155 a.
a a a a. a
S
a 'a
TCACGGAGTG
CAGCCAGAAG
AGCAACGCGC
GAAGTGCTI'
ATTCCATTG
GAGCGCTTTT
ACCTTAAACG
ATAGAAACCA
AACGCTAACA
AAAAACAACG
GAAGCGAAAA
ATTAACGAAG
AATAACATCA
GATCATTATC
TTGAAATGAA
TGAAAGAAAT
ATTTTAGCGA
TGAGTITGGA
AGTGGCTGAC
TI'AGCGAGTI'
CTAACGCCGA
CGACAAGACT
ACCAAATCAC
CTAATAATGA
CGAACGCTAA
CCAAAGAAAG
CGCAAGAAAA
AAAACATTGA
CTACCCTAAT
CACTAACGAG
GCAAGTGGAA
TITFTI'TAAG
TAACGCCGGC
TAATACGAGC
GAACATI'AAA
TTTAACGAGC
AAAAAACAAA
AATAAGCAAC
TAATGAAATA
CGCTACAACG
AACCCAAGCC
TTTTTGAG
CTACCTAACA
CTTTTAAAGC
TFTAAGCCTTA
AATGCGAATG
GAGAGCTTGA
ATGCATGCCA
AGCGAAATTIA
TATCAAATCT
ACCCAAAGCC
ACTCAAACGC
AGCAACAATC
CAAATAAACG
ACAAGCGAGA
TI'TGAA
GCGCTITAGA
AATTACAAAA
AATGCATCGT
AGATTGATAG
AATTAAAAAT
ACGAGCAGGA
AAAAGCTAGA
TTITAAACCA
TTGAAGCGAT
AAGCGATAAC
AAACGCAAGC
CCAATAAGCA
TCACCGAAGC
GATAAGCGAA
CGCTTTAAGG
TAGGATITA
CAGTTTAAGA
GAAAGAATAC
AGTAACCAAT
AAATCAATTG
AGCCAGAGAT
TACACAAGCT
TAATATCACC
GATAACTAAC
AGAAGCAATA
GAAAAAGACC
120 180 240 300 360 420 480 540 600 660 720 780 816 a.
a. a a INFORMATION FOR SEQ ID NO:1156: SEQUENCE CHARACTERISTICS: LENGTH: 1329 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .1329 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1156
GGATTGTCGG
ACCAAATTTG
GGGCAAAT'C
CGCATCAAAG
GCTGAAAGCT
ATTGATACGG
AAAAACCTCT
GGCAGAAGCC
GCTGATGAAA
TGGGCGATCA
GCGTGCGGAT
CGCTACGCTA
GTCAATATCC
GGGCAAAAGG
TG'rTAGAACG
AAACTTATT
AAGATAGCGA
AAATTGAAAA
TCGGCGAAGA
CTATGGCGTT
ATGAAACCCT
ATGGGGTGTr
TCAAACGGCA
GTGGGGGTCT
'TTTTAGGCTT
GGCTI'GCATG
GCCATTCA
GAAGCTCTGC
CTATGCGAAT GAAGAAATGA GGAAGTGGAA, AAAGCTGTCG
TTGTGAAAAA
AACCACTAAG
ATCCCGCTTC
ATTGATGACC
TAAAAATAGG
TGGCGAACCC
T
ITTAAAAGCC
CGGGAATTTC
AAAAACCGCT
CGATCTGGCT
ACGCAGTGAA
GATGCCTCAT
ATCTGCTI'AA
CATGATTTAA
'TTTCATTATG
AAAAGCT'AA
GCTTTAGAGC
ATCACCTTTG
CTGGATTTAA.
GCGCACGCCC
AATATCAGCA
CTTTTAGCGA
GTCTATGAAG
AAAAGAAACC
AAGCCCTATG
TI'AGGGCGTG
AAGCGGCATT
TCGCTTTCAC
GGATCACTTC
AACTCATrCA
ATCAAGACAC
GTCTAGTITI'
CGATGGAATT
CTTTAGAATT
ATCAAGTCAT
GAATGAGCAA
GAATAAGCTT
CAATCT1'GAA
TACTI'GCGTG
TAGCGATTGC
AAAAGGCGTT
GCTAATGGTG
AGCTCTTI
TATCAGCGTA
AGAAGAATTA
TCAAAGAGAC
120 180 240 300 360 420 480 540 600 660 720 780 840 GCAGTIGTGA AAAAATCGCT TGGAAGAAGC 'rITTrCAGCA CCATCTTGAG CGAGAATATC
ACCGGGCTTT
TGGCATGAAA
ATCACCAGCG
CCTAAAAACA
TTATTGGAAT
AATGCGATGA
TTA:17I7T7AA
ATCAGAGCAT
GTGTTTGGA
GCAGGGTGAT
GGGACATGAG
ATTTCATGCT
TGCTTAAAAA
TGCCTAAAAA
AAATATGGGA
ACGCCCTACT
GTfl'TGATTA TCGCTCTFF1'
CCATAGCTCT
CAGCCGT TTG
TTTAGCTITG
AGGTTTGAGC
GGTIT1'GCAA
TAACGATGAA
CAGCTATTAC
ACTACCCCCA
GTGGAGCGTT
AATAGCGTGA
AGTGGGGGGC
AGAGAAGAAA
CAAGGCGCT
CGCTTGAAAA
ACTAAAAATG
TGCTAGAAAA
'FIGCGCTGCC
TTGAAAATCT
TAGTC'ITTTC
GCTATTCTAT
TTAAAAACGC
AATAITTTGAA
TGGGGGCGAT
TGTCGCCTTA
TGATCTGTTI
GGTGGTTTAT
GCAACGGGTG
CGTGCAAGA.A
TGATGAAAAT
TGAGAGCGAA
TTTTAAAAGG
900 960 1020 1080 1140 1200 1260 1320 1329
*U
S
*5 S INFORMATION FOR SEQ ID NO:1157: SEQUENCE CHARACTERISTICS: LENGTH: 291 base pairs TYPE: nucleic acid STRANOEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAHE/KEY: misc-feature LOCATION .291 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1157 5* S p
S
AATGATAGTG
TIGAGCCGCA
AAGCCCATGA
GAAATAGATA
ACCCACCCTA
GCTCAAAACA
CACGAGAATA
TCAGAGCCTT
AAAATAGCAC
GTATTAAAA
TTTCATCTTG
CATGGCCGAT
ACAAAAGATI'
CCGATCAGCG
TCGTATCCAA
CCTITI'TTAA
AGCGGGGCGG
TCTAACGATT
GCCTATCTT
TCCTTAAGAA
CGCTCCTTT
CG7=TIAAT
ACACCAACAA
TI'AACGCTGA
AGCGTGTGAT
GCAAATGTAT
GCATGACAAT
CGATIATAAA
AATGTTTAGC
C
INFORMATION FOR SEQ ID NO:1158: SEQUENCE CHARACTERISTICS: LENGTH: 540 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: -NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I. 540 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1158 ATGGAAAAAT TTTrCAACCA ATITITTGAA AACATCGGCG AAGACAAGAA TCGAGAAGGT
TGAAAGAGA
GAAGATCCTA
GTGGCTCAAA
AATATI'AGCG
CTCAF1'GAAA
GAAACTI'TG
TTGTGCATGA
AGAGGCCTCT
CGCCTAAAG
GAGTGGCTT
ACATTGAATT
TGGGATATAT
TTI'ATAGcAA
ATGAAATCAT
GCATGCAAGG
TCAAAAAAGA
GGTTCAAGAA
AAAAAGCGCG
ITACTCCACT
CCCTAAGGAA
ACGCCTGCAA
AGAGCCAAGG
GGTGCAAAAG
CCCTAAAACC
TTATGGAAAT
TATTTTCAAG
TGCGAGCACC
AAGA ITGTAG
ATCCAAGAAA
GGCGTGATCG
CAAAATGCGA
AGAGCTGAAT
TCTTGTATA
GCGTTTGCGA
ATrTGCTCCC
GCATTAGCGC
GGCTGACCAC
TGGTTTGTGA
TCATTAAAAC
?I'ATGCAACT
A
TGAAATGATA
GATCGCTAAA
TCAAATTGCA
AGCCAAGCAC
AAGTGTG'rrA
CTTAA.AATCT
180 240 300 360 420 480 540
S
9*
S
S
Sea.
C
9 S a 55 9
*S*S
S. S
SS
9 S
S
INFORMATION FOR SEQ ID NO:1159: SEQUENCE CHARACTERISTICS: LENGTH: 924 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .924 (Xi) SEQUENCE DESCRIPTION: SEQ ID NO:1159 GTI'ATAAT2'C
TTGAAAGCT
AAAGCCT ITT
GCCGTGCTT
AAAATCGC'IT
TGCATGGATA
ACCACAGCCG
TCTTTACTAG
AITAAAGGCA
TIAGAGCAGC
A'ITATGGGGC
TTTGGGTTA.A
GATGAAAAAG
TTATTGGGGC
GATTTGAAG
AACACTCTAT
TAGGCATGAG
TTTTAAAAAA
?I'GAAATGGT
GCTCTI'TAGT
TAAGCATTGA
ACGCTATIT
TFI'TAATCGG
AAAGCCGTAT
TGATTTAGG
TCA.CTrTCTT
TI'GIGCGAG
AAATGGGTCT
AAAGCGGTAA
TAAAAAAGGC
CATI'AGAACC
TTAAAGGCAA
TAACCCTAAT
CCATTATI'A
GCTTAATGGG
GGGTAAAAAA
ATGCTI'GCAC
AAGAAGAAAC
CGATGCGCTC
CATTGTGGAA
GCAGGCTI'G
ACACGAGCAT
CGGCATTAAC
TTGTTTTCAA
AACCACGCAT
AAGCGGT'AC
TACTTATCTr
GACA
TTATCCTTTT
CACCTTGAAG
GGCAAAAGGT
GATTATrCT!A AcTTATrcGc
CACCCCACTT
AACACCTATT
TTAGTCAAAM
GATTGCTATT
A.AAAcccTA
GATGAAGAGC
GTGCTAGATG
TI'AGACAGCG
GCCCAAACI'
TCAI'1GCAAG ATrGTAATGA GCrI'CCACCC
TCCGCCCCAA
ACCAACAAAC
TCATCCATGA
TACACGCCAA
CTI'TGAAT
TCTTAAGCGC
F1'GAAAACAC
AATTGATITAG
TI'ITAAAATG
ATArI'ATAGA
CTAAAAACAG
TAAAAACAGA
AAAATAAA
GTGCGAGCGT
TTA'ITTGGAA
GCTTTTTTTA
AGAATATTIT
CGAI'TGCCT
ATACGATGAA
GCTCTCAAAT
TAATGGGGGG
CCCCTrAAAT
CGCAAGCCTG
GCTTCAGGCT
CGTTACACA
CTTTGTGAAT
GATTrAAAC
CGCATI'ATTC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 924 INFORMATION FOR SEQ ID NO:1160: Wi SEQUENCE CHARACTERISTICS: LENGTH: 1041, base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1041 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:116Q S S
S
*5S* S S. 5
*S
*5 S 5 *5 S S
CTI'CTCAATA
GTI'ATGCGAG
TTTGAAAAGA
GCGATTTITG
GGTATAGCCC
TTTIGTGGTGG
AGCGGCGATG
ATCCATCGCC
TATATCATA
CTTATCGCTC
ATCGCTCATG
ATITIGAGCA
CGCAAGAATA
CCTT7TTTAA
AGCGGGGCGG
TCTAACGATT
GCCTATCTT
TCCTI'AAGAA
CATCAAAGAA
CGCGCTGCTC
FrATCGCGCA
CTI'TTATI'GG
TITI'TAAACT
CT TTTGTCAT
AATACAAGCT
TTTGTAGA
ACGCCCCTTA
TIACAAGCGC
AGCTCAGCCA
ATATCATGCT
GCGGGGCGAA
CGCTCCTTT
CGTFTTAAT
ACACCAACAA
LTAACGCTGA
AGCGTGTGAT
AAAGCGCAAT
AAAGAAATCA
AAACAGGCTC
GTI'GTTGGTG
CATGACTTTT
TATTCITGFT
TATTGACCCA
GCTITIAGAA.
CATGAACGCT
TTAATAGAG
CATACGGCAC
ATTGGTGGCT
TTTAGCCCGA
GCAAATGTAT
GCATGACAAT
CGAI'ATAAA
AATGTTTAGC
TIGAA ITGGA
AGCATGAGAA
AAAACGAACG
GATGCTATI'A
CAAA'TTTTC
TGTATCCAAA
AGCAAGGTTI'
GAGGCTAAGC
'FTrGCGAGCG
AGGTTAGATA
AACGACATCC
AATI'TTAGCG
ATGATITTAT
TT1GAGCCGCA
AAGCCCATGA
GAAATAGATA
ACCCACCCTA
ATTTTACTTG
AGGAGAAAAT
CGGTTITAAC
GAATCAACGC
CTACGATTAC
A TITTAGCTC
TAAGCTCTAA
TTCATPITGA
GGTGGGATGA
GAGACGAAT
GCTI'GACCAT
TGTAT' TTTT
GGGTI'TACA
CACGAGAATA
TCAGAGCCTT
AAAATAGCAC
GTATTAAAAA
CCTAAAGGGA
AATGACGAAT
CACTTACTGC
TAATGAITTTA
TATTGTCATG
TATCATGTTA
AGAAAATCAA
GCCTAAGCT
ATCTAhTI'CC
AAA.AGCCGTG
GTGCGTGGGG
CATGGGGAAT
GATCATCTTG
CATGGCCGAT
ACAAAAGAT1
CCGATCAGCG
TCGTATCCAA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1041 INFORMATION FOR SEQ ID NO:1161: SEQUENCE CHARACTERISTICS: LENGTH: 195 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 195 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1161 ACACAGCCAC ACAAAAACAA GAGA'FrAAAC AAGAGATTAA ACAAGAGATr AAACAAGAGA TTAAACAAGA GATTAAACAA GAGAT1'AAAC AAGAGATI'AA ACAAGAAACT AAACAAGAGC AAGAAAAAGA AAATAAGCCT AAACAAAACA GTGTCTCGCC CGTTCAAAAC GATCAAAAAA CCCCCACAAC CCCCT INFORMATION FOR SEQ ID NO:1162: SEQUENCE CHARACTERISTICS: LENGTH: 414 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION .414 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1162 *3.3 3 3 3* 3. *3 33 *3 3
GGGGTAAACA
AAAAACACCG
CCAAAAAATT
TrT1'TATCGC
TATI'GTATT
TTGTTAGATA
TGCGCTAAAA
TGCTTAITTI'
ATGCTXI'TCA
TGGAAT TAGC
ACAAGATAGA
TTAAGGATAT
GCAAAATCTT
ATCAAATAGA
AGGACACCCT
TTCCAGCGCC
CCAATATTGC
GACGGACACC
TAAGCAAGCC
GTITI'CTATG
TGGTGTCATT
TTAATCCCTA
AATAACGATA
TGTGAAAATG
TFITTTTTAT
ATACTCGCCC
GAT1TTTAACG
TCTAAAGATT
GCGCTCGTTT
TAGTGTGTTT
GCGTCCATT
TCAACGCTT
AACAACACGC
ATACAGAGTC
CACTCCTITT1" TGITrTCAT'
TGAAGCAAAC
TAGCGTGATC
CAAACCGCTC
CACTAATTAC
ATGGGAGATT
GAAA
120 180 240 300 360 414 .3 *3.3
S
3* *3 3
C
INFORMATION FOR SEQ ID NO:1163: SEQUENCE CHARACTERISTICS: LENGTH: 402 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc_feature LOCATION .402 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1163
TTITAAATGCA
ACTATGAGAA
GCTGAGCATG
ATI'ACGGATI'
GATAACCGAT
GTCATTACGA
GTTTTGAAAG
ATCTTAAAAG
GGGTGGAAGC
GGAACATGCC
TI'AAGGAAAT
CTTTAAAAGC
AAAAATTAGA
GAGAAGTGCT
AAACACACT
TTGGGAAAAA
TGAAATGAAC
C0CTATCATI'
GGGCGTGAAT
GGTTGTTTTA
TTGAAACTAC
TCACGCTTAG
cTAGACGCTA
GGGTTGGATC
ATCATCACCA
AACTACATTG
GGGACAAACG
TGGTAGTAGA
GCTATGA.&GA
ATGCGGACAC
TCG~rAAAAA
CAGAGGGCGG
TGAAACCTTT
AT
TGATAGCTCA
TG~rTAGAA
TAAGGTGCTT
GGTGCGTGCG
TAAAGCTGALG
TAccccccAA 120 180 240 300 360 402 INFORMATION FOR SEQ ID NO:1164: SEQUENCE CHARACTERISTICS: LENGTH: 840 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FFEATURE: NAME/KEY: misc-feature LOCATION .840 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1164 a CGGGr1'ATGG
CTCGTATCGC
GGGGCGTTTT
GCGTTGTCGG
GAAGCGAGCA
AGGCTGTTrG
GTTOTAGAAA
GTITGGGTGC
GTGGATGCGT
ATTTTAGGGG
CAAAACTCAC
TTAATTGAGA
GCCTTTGTGA
ATGGTGTGTA
CGGTGCGAAT
TCTTTTTAAG
ATGGGCTAAA
CG PTTGTTTA
GCACGATT
CGAATGAAAA
ACGGCAAGCA
CAAGCGGGGC
CTTTGATCAG
GTTATGTGAA
GCCTTTCTAG
GCAGCGCGAA
GC'ITTATT
TTAGCGTGCT
CATGGCGACG
CTTGTTGGTG
AAATGGCGTT
TTCCCTTTAT
AACGCTTGTT
ATGTCTGGCC
GATAGAAAAA
TAAAATCGCT
CGGGGAGTTT
CGTGGGCGTG
TTTGCTAGAA
TAAAATCGCG
GTGGCAATTr
AGTCATAAGC
GTATGGACAA
CTAGTGGTGG
TTGGGCATGG
GCGATGTTGG
TTTGGCTCTA
CTAGAATCGC
CACCCTAJAAG
ITAGATGGCG
AAGCCTTTGG
CCI"ITAGCT
ACTTTAAAAA
GATATTTTTT
GTTGGGG
TGCCCTITGCG
ACTCATGcAA
TGGGGCGT
AITTGAGCGT
TGTCTCAAGA
AG TrTTGGA
ATGAAATCCA
ATGTGGCGAT
TGCTTTTAAA
AAITGGGGGT
ATCAA.GTGAG
AGAG7 11T171 CTAAAGcG.GT
GTAATTFFIGA
CGTTCGCTCG
GGAATTTGGA
TTI'CATTAAG
GTCTTTTGGG
GACCTA'rrIT
ATTAAAGGCT
TAGCGTGATC
AGGCTCGGTr
TAGCGCGAGC
TAATGATCCA
CGCGACCTTT
AGAAAAGCCC
GTTGT1TITTA
AAAAGCTITA
GCTACGCCCA
120 180 240 300 360 420 480 540 600 660 720 780 840 a.
a INFORMATION FOR SEQ ID NO:1165: SEQUENCE CHARACTERISTICS: LENGTH: 588 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .588 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1165
CGTGCTAG'C!
GGGGTGTTA
AAAGTGAAAA
AAA.GAAAAAA
AGGGAGCArr
GAAAAGATAG
GTGGGGAGT
AATATCATGG
CGTTTGAAAG
GAAATTTTAA
ATAAGCTGCC
AAAACCCT1'
AAATCTTTAT
TCATTCATGA
TAGCCCATAA
AGTITI'TCGC
TGAAATTr TAGGCrrI'Gc
CTAACGCTAA
GCGGGGATAA
CTTGCGCGTI'
GATCGTGTIT
AGACAAAACC
AGAATTTGAT
TGCGATTCTT
TCATGGCCTG
AAACGCTATG
GAAAAATAAG
AGAAGTCAI'r
TGAAAGCTCG
CGCTCGGCTA
AAAGAAGCGT
GGCACCCTCA
GAAAGGCTTr AAAACA LTAG
AAAGCGAGCT
GGGGTI'GATI'
ACC'ITATGCG
CAGGCTTTAC
GI'AAGGAGT
CGCCCATAGC
TGTTrIAGA
CGCAAAAAGA
TAAAGAGCCT
ATGGCGATGA
ATCAAAACGA
TAAAGGTI'AA
CGTTATCAT
AAAATCAAGG
GCGCGAAA
GTTAGTGATA
AACTCTGGCT
AGTCCTTrA
TTTAAAAACT
GGTIGXITG
AACCTTGCTA
AGAGAGCGCT
TTTAGAAGAG
CTGGAATTA
120 180 240 300 360 420 480 540 588 INFORMATION FOR SEQ ID NO:1166: SEQUENCE CHARACTERISTICS: LENGTH: 2001 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO.
(iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .2001 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1166 *999 9 9 9*9* *9 9 999* *9 99 9 9 9 9* .9 *99* 99 9* 9* 9 9
ACCCCAACCA
TTCATGAGTA
ATTTACATCA
CAATTAAACA
ACTI'CTATTG
TI'GAAAGTCT
GAGGTCGCGA
TIGATCCGTT
GATACCGGTG
TATATCCAAT
TTAAAAATCA
AATCTCAACG
ACTTATAAGG
GATGTGAAAA
TTGATTCACA
CTGCATI'TCA
'rTC1'TGCTCA
ATCGCTATAC
TI'GCAACACA
AAGCATGTGG
ATrTCGCGC
TTI'GCCATGC
CTCATTAAAG
ATTTATGGCG
GTCTTAGGTT
CAAATCAATG
ACCGCTITAG
CAGGTTTTTG
ATAGAAACCT
GAAGTTAGGG
TACCCCATTC
AAGCTCTATG
CTCAAAACCC
ATCACGCTGG
AAGCCCCTAA
TCGCTAACAT
TTITAAAGA
GAGTAAGCAA
GCTGGGCGTA
TGCAAGATFI'
GCGTGGGGGG
ATAACT1'GAG
GGGGCGTTAT
CITTAAACGA
AAGATATAGC
GCGATAAGGA
TGCTTAAAGC
TCACCAGCGT
AATCGTGCAA
TGACACGGT
CGGCGTCAAT
TCTGCCTAAG
TCAATACGCT
CTATI'ACCGC
C ITG.LTGAAG
TTTAGAACAA
TTAGAAAAC
TTTAGAAGAA
GAGCGTTAGG
AGTGGTGGGC
CATITAAAGAA
GTATGACAGG
CGCTCATAGA AGAAAGCGTC GGAGCGCITI AGTGGTGATT
TGCGTTATTT
GGGCGATGGT
TTGACACGAG
GGGGCGCGAT
TCACCGGTCA
TAGTGGGAGC
GGCGGATTr
TGAGTTTGAG
TAGGGGGTT
AAGGGGTAAT
AATATIGAA
GTAAAGTGGG
ACA'ITGAAT
ACAAXITGGA
GTGGCAGAAC
GTAACGACAC
TCAAAGAGAG
ATTTIGGAACG
CAATAITGAA
GGATGCGGCG
AGACAACACT
AVTTTIGCC
AGAAGAAAAG
GCTGCTTI'CT
AGAAGAGTCC
GGTTGTGCTT
AGTTGTAGCG
CATGTATATG
AAAAAGTAAC
GCGCGCTAAC
AAAGCCGCAA
AAAAACCCTG
GGACATGCTC
GGACAAATTA
TTTGTCCGGC
GAGCAGGTTA
ALGAGGGATTT
TTGTATGGG
GACGCTAAAG
FI'ATCTAGCG
TATGCGCTI'
GATI'ATGAAG
GTCGCTAACG
GGGTTTGAAA
AT1'GTGG?1'A
CTAGCGCCCA
GGGATI'GTTA
AAAATCGCCA
AGCGAATTGA
ATI'CTGCTAG
ATCACTCTGC'
GCGAGCATCA
ATAGTGATGG
CAAAGGGTTA
TTAATGATCA
CTTTTTGCCC
ATTACCATAG
GAAAGCCCCG
AAGTTCAGAT
TATAAAAAAC
CCTGTAACTA
GCTGCTATCA
ACCAGCACCG
AACGAATGGA
CAATTAAAGG
TTAACCGGCA
CAAGAATI'GG
ITTGCCGAGC
CTTACCCGTT
CTAGCTATGA
CTAGAGATAG
TGGAAATAGG
ATAGCAAGAA
TGGGGGTTGA
TAACGCTTCA
CGATTAAAAA
AAATTATAAG
AAAAAGAAGG
AACCGCGCAG
TGGTGCGCTA
CCTTACAAGC
TTGAAAAAGG
TCATTAT'GC
CrAAGCGT
TGAGTTTGGG
TGGAGAACGC
ATGCCATCAT
TCGTGGTTI'C
CITTAGCTTA
TCCCTG1T
TTAACGC'TTT
ACGCTTIT
TCAACTGGGA
TI'AATGGCGT
AGCAACTGGA
ATGCCGCCGG
AAGAAAAGCT
GCTI'GACTAA
TI'AGAACGCC
CGATCCTTAT
GATCCAATAA
GGTFI'CTACT
AAGCGGCTTG
GGTTI TAGAG
GAGCGATTCC
TTTAAGCGAT
TGGGGTGAGT
AAACGAT1CT
TTCCAATAAC
ATCGCATGGC
GGCTATCCCT
AGGGGCGGCT
TCACGCTGAC
GAGTAACCCT
CATTGACAAT
GATTI'CTTA
GTGCATCAGT
GGGCAT1'GCG
TCACAAGCAT
GCAAGGGGTT
TTTCTTGCCT
CACCAAAACC
AATGGTATIGG
TTTCATGAAA
AATAGCGAGC
ATTTATCCCC
GGGTATTGAT
TTTTGTCAA
TTTIAGGAATG
CAGCTATAAA
TTCATGGACT
CCTAGGCATC
GGAGCAACAG
CGGCTACTAC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 i2 1320 1380 1440 1500 1560 1620 1680 1740 1800 1860 1920 1980 2001 INFORMATION FOR SEQ ID NO:1167: SEQUENCE CHARACTERISTICS: LENGTH: 285 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .285 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1167 @9 9. 9 9.
9 9
CGCAACGTGG
GITITACAAG
ATCAATGCCG
CAATTGGCTA
AACGCAAGCC
AAGCGCGTTA
AGTTCGCTCA
CTCGCAGTCC
AAGA.AGTGTT
ATTTCGCTTC
TTATTATGGG
CTTTGGATCG
TTTAAGCACC
TTTGAATI'G
CAA ETTAGGA
GACACTICAT
AATGATGTGG
TATGCAAGAG
GGCGTGGTFI'
ATGAGGTATA
ACTTI'TATTT
CGTCTTTAAA
CGATGATGGG
ATTTGCACAA
G'FITC
GCATGCGGGA
CACCITTTAAA
TGGGGAATTG
TT1'GATTTCC 120 180 240 285 9 9@ 9 9 INFORMATION FOR SEQ ID NO:1168: SEQUENCE CHARACTERISTICS: LENGTH: 633 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .633 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1168
AAACCTACCA
GCTTCAT1'GT A'I GTGGGCG
AACTCTCGGG
GAATTI'CACT
AGCACTCTAT
AGAGCGAGTT
GTGGGCGTGA
GTGGCTTTAA
CGCGTTATTA
TCGCTCACT'
ATGTrGGGC
ATGGCACAAG
GTTTTGGAAG
CCAATAACGC
TTGAAGCTCA
TACAAGATT
ATGGTTATGA
GCTATAACCA
AAA.ATGGCGC
TTATGGGGAC
TGGATCGAAT
TAACGCTAT
CGCCGGCGTA
CTATGGTTAT
TAATTGGC
ACGGGGCGCTA
GAATCAAAGC
CTI'CGCGTIT
TTTAGGICA
GAGCAGTCAG
ACTTCATACT
GATGTGGCGT
GGGGGAGCGA
GACGCTTTCC
AGCTCCITTTA
GTCTATAGCC
GGGAGCGATC
TATAAI'TACT
1'ITAGGAACG
ACCAACTTTA
CATTTATI'CA
TTTATTTGCA
CTT
GCTTGAATAG
TTAACGGGAA
GCAATCAAGC
GTTrTTGC AATCAAGC?1'
TAGCCTATAG
C'ITTAGTGT
AAAGCAATAG
ACGCTAACGC
TGCGGGAGTT
CGGCTCTAAC
TGTGGAAGCC
GAACTCTCTI'
CAACCACCCT
GAAITTCAAA
CGCCACAGCA
AAAACCAAGC
CCAATCACAA
AACGTGGAAG
TTACAAGAGT
INFORMATION FOR SEQ ID NO:1169: SEQUENCE CHARACTERISTICS: LENGTH: 234 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .234 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1169 9* S eS. S AATAAAATCC TAGCCAGTGA GCTAGAATIT AAATTTTTAA TCAAAGGAGT CACCATGAAG AACAACACGG CGGGCACCAC CACCATCACC ACCACACACA TATCATGGCG GCGAACACCA CCATCACCAC CACAGCTCTC ATCATGAAGA AGCACTAGCG ATAGTCATCA TCAAGAAGAA GGITGTTGCC ACGGGCATCA INFORMATION FOR SEQ ID NO:1170: SEQUENCE CHARACTERISTICS: LENGTH: 1035 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1035 (xi) SEQUENCE DESCRIPTION: SEQ ID NO;1170
CATCATGGCA
CCACCACCAT
AGGTTGI'GC
CGAG
GGGGTTITGA
TACTACACGC
ATTIGAAAACT
CACCCTAAAA
CTAGCCAATC
GGCAATCCCC
TTCATTITTG
TC 1ITCAA
AAAGAAGCTA
TTGTTT
TATGAGCGAG
CATACGACGC
AACGCTAAAA
CTCAAACGCA
GATAAATTGA
TAT1TATTTTG
GCTTTAA
TTAGAACCCC
CCCCTTA TT ACACGC2F
AAATAGGAGC
CTAAAAGAGA
CCTATAACGA
AGATAGACAA
TITTTAAAGCC
ATTTTAAGCA
CTTCTAAATC
GGCGAATGGA
TATGCTTAAA.
AGGTTGGGGC
ACAAAACTT
CAAGCATTA
AGTGGAT1'GC
AGACACCGCA
GGATATI'GAC
AAATI'ATGGC
TAGAACTTCC
CGATTrGAAA GGCG1TTTATI' AT1AAAGCTA
TTI'CACTAAA
CTATGCAGGT
CGATTGAC
ATGCGTGGGC
T]TTAAACGCG
ACCAAGCAAG
GCT1TACAAGC
TGTGGTAATA
CCTAAGTGTG
ATAGCCAAG
TTTATCAAAC
TCCCGAGAT
TGCGTGCTAC
TITAAGGATC
AGTAACGAAT
ATTAGGCGI'
TACATAGCCA
TATITITTTC
CCAAGCGAAA
TATr'ITAAGG
AGAGCGTGAA
TTAAAAAA
AAGAGTTF
ATGCTT'AAT
ATGAACCITTT
AAGATAT1'AA
TAGGGATAAG
ACCCTTTATC
ATTACAGGCT
TICCTATI'GT
TI'GT1'ITCC
ATTATGTGGA
CTATGCGAGA
ATGCGGTGCG
AAATI'GCTCC
CTITTAGA
TTTAGGGGCT
GCATGTTGGT
AAAGCTCCAC
AATAAACGCT
AATCATCGTG
AA.ATAAAGAT
'IIrAAAA
TITATCTCATC
TTTAGACGCT
GATAGCTTTA
AACTGAT1'GC
TAAATACCCT
CATTAACGCT
AATCAGTCAA
TAAAATCCCT
AATTAAAGAC
TCAAGGACAC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 t TTATI'ACCA ATATATCCAT GTAATI'GGA TATTATCATI' AAGATAAAAG AGCGCGTTTA GAATATTTTA AAAAATI'GTT CCTIGTGAGT TIGAT INFORMATION FOR SEQ ID NO:1171: SEQUENCE CHARACTERISTICS: LENGTH: 786 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION l...786 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1171 1035 *99* 9 9.
9 9 9.9.
.9 9. 9 99 99 9 9* .9 9 *9 9 .9 999* 9 .9 9 9 99* 9
AATATITTAA
AAAAAAGTGA
ATCAGACATG
TTAAAGCATT
TTI'GAACTCA
AAAACTCTTT1
TTAGAAAATI'
AATTTTATGA
CTCTTACGCA
ATAGTTATA
TCTATTTTGG
CATGCCCTITT
TTI'GGACTTT
CAAAAT
AAAAT1'GTTI'
TGAGGTTTC!
CCTTTAGCGA
ATGTAGAGTG
CTACITTTAAA
ATGAATTGAG
TAGAAAATAC
'ACAAGAGA
ITTCT'ATC!C
AGGAACAACA
AGTTAAAAAC
TGATI'ATCCA
TAAGCCAAGT
CAAGGACACC
TATrCCT1rA.
TTATGGTATI'
GCAGATCGGT
AGATGAAAAA
CGAAATGATT
TTTAAAATTT
AAGATTl'AGA
TTTGCTCATI'
ATATGGCTCT
CGCTACCCCC
TGAAACCAAC
GCACCATAAC
CTTGTGAGTT
ACTTCCXITT
TCAACAGCGA
TATGATGTCC
TATCATTT
TAI'ACGCTA
TTAGAAAAAC
TCGCATCAAT
CAITCIrG
AAAACCCAAG
TTATTAAACA
GCTCTTGTGT
GATGTGTTAA
TGATI'AAAGT
CAGGCAAAGC
CTAGAAAAAT
CCATTAAAGA
TAGGGGCTAA
AGCGATTGGG
AAAAACAATT
TTGGTGGCAT
ATGATAATGA
CCATGCTGTA
GAACCGCTAT
TTFIAGAAAT
AGATITAGA
TAGTGGTCAT
GCGTGTGAAA.
CCCITrI'AGT
TAAAGAAAAA
TAATAAAGTA
TTAATCAGT
TATAGAAGAT
GGATTIWGAA
GI'IGAGCGAA
TFITTGCTI'
GCCCAAAGAA
GCTI'AAAATT
AAAAATACTT
120 180 240 300 360 420 480 540 600 660 720 780 786 INFORMATION FOR SEQ ID NO.1172:.
i)SEQUENCE CHARACTERISTICS: LENGTH: 1239 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (i)MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1239 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1172 845
TIGAAGGCAT
TATTCTFI'AA
GGAATGGCTA
CTGTTAGGGT
CAAGATAAAG
GCAAATAACA
TACAAAAIAAG
AGAACCCTCC
GACCCCCTT
CTAGTGAA
'TTI'GGCCAGC
TTTTCCCATT
CTAGAAACCC
CCTGTTFI'AA
TI'GATCCAT'
AAGGTGGT'G
GCTAACGGAT
AGCACGGGTr
AITAATCCTT
GTTTTAG
TCI TTGAAA
TAAACGACTG
TGGTJTGCTTT
AAAAGCAAAC
TI'FTAGAAAA
AATTGAGTGC
CGCTCATTCA
GAGAGGATTA
TrTTTCcTr
TAGCCAACCA
ACGATAAAAT
CGACCATCAA
CAAACGGGCG
CGGTGAAATA
A).GTTAAACG
CTGCTTCAGA
AAATCCAT
TAA.AAAAGG
TAAGCACCGG
TAGGCTATAT
AAAAAGCTCA
AAAATTCATT
CATGGTATTT
TTTATTCCAT
TCTTTTAGTG
AAACCATATC
TGAAATCCAA
AGCCCTTATC
TTTIAGAC
ACAAACITCG
ATTGATGAAC
CGCTATCGTT
AATGGCGATG
TTATTACGAT
CACCCGCAT'
GCCTCAT'AC
CGGCCGTGTG
GAATGAATTG
CTCGTTCGT'
GCCGCATTTG
CCGCACCGCT
GTATTCTAAG
TTATCTFA
TTTCATAAGA
TTATCCTATG
GGTGAAAGGC
CCCCAAAAAC
AGCAATGI'A
CCTATI'AGCC
TITATCCCCA
CCCTATCAAG
GCGTATAAAA
TATACAAGGG
GT1AGCTCTC
TCAAAAGCGC
TCTTCGCCTT
GGCGTGGATT
GGITTTTATAG
CGCTTGGTGT
AAAAAAGGGC
CATTGGCG
AAAAGCAAGC
CAAAAATTAG
GAGGG71TI
AAAITATT
GGGTTCTTTT
TTGTGTGGGA
TCTACTACAA
CCTACTACAC
AGGXTTTGCA
TTGTTTTCAC
ATATIGTCAA
AAAGCGTGCC
ATI'ATCGTGT
GTI'TGCACCA
AAGAAGTGGC
TTTCGTATGG
ATGCGGCTAA
GGGTTAAGGC
ATGCTCACAT
AAATCATAGG
TGTATAAAAA
TGCATGGCAA
AAGAACTTI'
AAATITI'ATC
AAAAGCCGAT
TAAGCTCACG
TTTGAGCTCT
TTTAAGAGAT
AATCCATATT
TCGTAAAGAA
AGCCACCAAT
TrrAAACGC
GGGGCAAGCG
ATACTATCTT
AGGGTTIT1'A
GAGGTTICCAT
ACATGGCAGT
GGGTTATGGG
GAGCGCG'ITC
AAGAGTGGGA
CTCCCGCCCC
ACAAAGAGAG
TAAAACCCAT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1239 9 9 0* S 9 9*
S
9* 99*9 .9 9 9 9 9* 9 9, e 9.
9 3 9* 69 9 9.9 9 INFORMATION FOR SEQ ID NO:1173: SEQUENCE CHARACTERISTICS: LENGTH: 759 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1.._759 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1173 CGATGCTTGA TGAAAAGCAT AAAAAATIT CACAAGATAA TTGCACATCA TI'AAAACGCA GCCCCCAAAG AACATI'CTTG CTAGGCACT' MTTFI'GCC CCTAATATCA ACCCCTACCA GTATTTAGGC ATATI'CTITG TGG TTT CAAA TITATAATGA GAACTCATCT ATGTITATCC TCTGAAAT'T GGATAGGTrG CAGCCTTTTA ATAAAGAAGG AAAGATTATA ACGGGCAAAA AACGCCCTGT GITTCGT 9
IG
TTTGCTCTT'
?TTAAGGTG
AAACGATTTG
GGTGGATIT
'TTTTATCAT
ACGCAATGAG
GACTAAAGGC
CCCTCAATCC
TATTAATT
GCAGCACATI'
TAATCCTGAA
AGATGTGCGC
GTGTGGGAAA
ATGA'TTTTG
GATrATAACT
TCCAATGCCT
GCTAAAAAAT
AGTTTCACCC
'FTrAAGTTCC ACGCTr1'ATC
GCCCCCATGC
AAACCTTT'G
TCTAATGGTG
AACCAGTTTC
TGGGGGGGGT
AGGGAGGCC
TAGTTTGTCA
ACTATr1'GCG
GGTATCTCCC
ATTAAACAT
CCATTTCA
AAATCAGTTT
TGGCTTATAC
GAATGATCAA
GGGGTAAAAT
TGGGGGGTGC
CAGGACAACC
GTCGTTCGGT
GTTAGAAGGC
CAAACAGGAT
TCCACAAAAA
GATGGATrTAT
ATGGTACCAC
TAGAGTGCCT
CCAAACTAAC
TTTCATGCCT
AGGGAATTTT
GCAATGTI'AC
TGTAATCGTT
GAGCGCGGGC
INFORMATION FOR SEQ ID NO:1174: SEQUENCE CHARACTERISTICS: LENGTH: 272 base pairs 846 TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .272 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1174
ATGTGAAA'T
ATGATAGCTA
~TTAATTT
TCTTACTGCC
GGGATAGAAT
AAAGGGCATG
CGGCCAAAAA
TCTTTITGCG
CGTCATTGGC
CCTTCTATCA
GATAAAGAAG AAAATGAAGA AGCCCTTrCC AAAAGCTATG GTITITAGTGT ATITITI TCT GGITI'AGAAA AAAACGCGCT ACCATCAAAA AA
AAATAAAA.TT
GATATTGTITT
GGCATTGAGC
AGAAGCCGGG
AACCAAGCGA
GGTGGGGCGT
GGGGAAAAAG
CTGTTAAAGG
120 180 240 272 INFORMATION FOR SEQ ID NO:1175: SEQUENCE CHARACTERISTICS: LENGTH: 279 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .279 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:117S
AGAATI'GAGT
CTITTTGTTGT
CCAGCCI'AG
?TGCCAACGC
ATGTTI'AG
GGGGTAATAG GCAITGTGGG TI'GGGGCGTT TTTATCTATC ATGGGGCGCA AATIGCTAGGG CCATACAAAA TGCGTTGTGG GGCTTFAA TGACATTACT GCGTTAAGCC ATGCCAATAG AATCTAGGGA ITTAAATTT GTCG~Tr TA AAAATATTTT CTAGTGGGGG TGGGGT
CGTI'TGCTA
CGTGAGCATG
ATrACCCAT'
TCATATCGCT
GGTITTTGTC
INFORMATION FOR SEQ ID NO:1176: SEQUENCE CHARACTERISTICS: LENGTH: 1272 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1272 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1176
AATTTAGGCG
TTATGTGGGG
ATAAGGATI'G
CGCATCATCG
AACGCTGATT
GGCGTGATCC
ATCACGCTAG
AGCAAATATT
CA'FrTGAAAT
TATCATATCG
GGCGAGITAG
GATACGGTGA
TCCGAGTTTG
AGFI'TAGAAG
AAGCTG'ITAG
GATATI'CTCC
CTTGTTGTGG
ATAGTGAGCG
GTGGTGTTIG
GTCAAGGGAG
CGTTTGATAG
ACACATAATG
GAGCGGCCAA
TAGTGGGAGA
ACACTTCAGG
CGCAAAACCA
TAAGAAAGAA
TTTCAGATTA
CTAATAAGCA
CCCATGCGAG
TAGACAGCCA
CTATGCCTT
TCAATTGCCC
TAGCGTCTIT
CTAATGCGGC
AAATCGCTT
AAACTI'TAGA
ATAAAGGGCA
GGTTAAATAG
AAAAAGACAG
GAGAAGACAC
CGGACTACCT
AAITTGAAGA
AT
TGTGGCTAAT AACCTTACCT TGATFI'AAAA GGCAAGCATT TGTTITAATA GATAAAACCC GCAAATCGTG CGCGTGGATA TCTrAGAT TTTATCGCAG CAATAAGGGT GTGITGGATT TCATAAGCTC AITITATGCG TTTGATCACG CCTAATCGCG TGCGAA TT1'A TCAAAAGCGC AGTAACCTTG AGCGAACAAG CACTATCGCT AAAGAAGTI' AACGCTCTCT 1 FrATTGGAAT TGCGGCGGTG GTGGTGGGTA GATITTTGAAC CAAACGCACC ACGCAACCAG CAAAAAATCG TGCGAGCTAT TTGCAAAAGG CGATAATTCC ATI'AAAAGGC GGCG TTCTr TAGCCAGCT GCCCATAAAA TI'GA'FrCAAG CAATAAAGAA GTCATAGGGA AGGTTATrCC ACAAGCGCTA
CTTTAAAAGC
TCATTAGCAC
GTTGCACCAC
AGGAAATCAA
AAAAAATTCA
TTGAACTCAC
ACCCTAAAGG
CTGAATTAGA
TCCAAATTT
GCATCGCTTT
ATGATGTAAC
CAAAAAGCTT
AAATGGGGAG
CTAAAATCCT
TITTCACCAA
CTAAAGCTT
ITAAGGGGGA
TGTCITGCGT
CCCTAAAGCC
GCGAGTTGGC
TCATAGAAAA
TAAAGTCITI'
TTTAAATTCT
GCTTAAAACG
AGACCCCTTA
AGAAATAGAT
TCAAACCATC
AAAGGATI'AT
GCAAGCGCTC
ACAAGAAACT
TTTAGAAAAA
GGGGGCAGGC
GAAAGAAGCT
CGCGTTAGCG
CCCTTTAGAA
TGGCTGTTTT
AGGGGATATT
TAAACGCCCC
GGATTATGTT
TGATATTrTA
TAAAGAAACC
AATTAAAAGG
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1272 INFORMATION FOR SEQ ID NO:1177: SEQUENCE CHARACTERISTICS: LENGTH: 963 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .963 (xi) SEQUENCE DESCRIPTION: SEQ ID NO; 1177 GGATCGCTTA TGGTGAATGT GTrTI'CAAG CAGCAAAAAT TCGTCAT'AA AATGACTTTA ATGGTTTTGA TATAGAAGAA AATGAAGTGT TGTGGT1TGA CCTACGCCCA ATGAAFI'AGC CACTCTAAGC CAAGAATACG CTATCCACTA CATTCCCAAC GAGTCTCATC AGTTACCAAA TACTGGGAAG ACAGCTCCAG
AAAACGCTT
AT1'AATCAAC
CAACACGGAT
CGTTACGATC
AACGCTTT
ATTITGTCTA
ATCCAAAAAA
AAAATCTT'G
ACGAGCCTGT
GTGCGCTTGT
CGGCGCATITA
TTAAATATCA
TCGCTTGATA
AITAAACTCT
TATGGCATGA
CTGATI'GTCA
TTG
TCACCAACCA
ATAACATI'CT
AGGTrGGC AAGTGTAT1'
TGCGCAAAAA
CCAATTTGCA
TCACCGCTTr
TITTAACCGA
ACATrCAAAA
TCACTGTGGC
ATTTTAAATT
TGGCGATTTC
GGATGAAAAT
TTTCACGATT
TAGCCCTAAA
TGAAAAAGGG
CATCATTT'C
AGAATITAAT
ATTAAGGAGC
TTI'TAGCTCT
CCTGTTCGCT
GACTATGGCG
CATGCCGGAG
TACGATTI'G
GAGACITI'CC
TATTACGGGA
AAATFI'GAAG
GTGGAATG TT
AAAGAAACTT
GTGGCTITAA
AATAAAGTGG
T1GGTGGAGT
TCTCAAGTCA
ATGATGC CC C
TTAGAATGGC
CCGGTGATIT
ACATGGAAAT
CTTTAGAAAT
ACGGGTGA
TGGAATGGAT
CTACGCATGA
GGGATTCCTT
ATAGCGATAC
CTAcAACGGT
ATGTGGAGCA
CCACATl'GAT
AATACGGGTA
ATTTCAAAAA
GGCGACCFT
C'FITGA'ITCT
TA2'TCTAACT
CAACAAACAA
TGATATI'TA
TTTTGACAAA
TAAA.AATAAT
CAATCTCAAC
AAATAAAATC
TGGCACGATT
TCTT'F'GCG
GAAGGGTTGG
INFORMATION FOR SEQ ID NO:1178: SEQUENCE CHARACTERISTICS: LENGTH: 732 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .732 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1178 0 0 *0 CC T1CATGG
TCCTI'GGCTA
ACGGTGATGG
GGCTTAGCGA
CAAAAGCCT
TTAGGGGGGG
AAAGAAAAAC
TTAGACATTG
GAAGTCATGG
GTI'GGCGATT
GTI'GTGGGCG
TATGCGGGTA
ATCZAAAAAA
AATTrATC
CGCTCACGCT
TITTATAAACT
TGATCACTCG
TATI'CGCTAT
CGT'I'TTGGC
GCCAAGAAAA
TTTTTCTTr
CGCTTGCTAT
TTATTGAAAA
TGTTIGTT
TI'GGTTTTGC
GT
CTCACTCTTA
TITAGAGATC
CCCCAAACAC
TATAGGGCTr
AGCGGGCATG
TTTTAAGGCG
AGCGTTTGGC
GGACTCCGTG
TATITTATCT
GCATTATCGC
TTTAGAAGGc
CTTGCTCATA
GACGCTCTT'
GI'CTAGGGA
CAGCAAAATA
TTAGGGAGCT
AGC771TTCVAT
'ITAGTGGAAT
TIICATCA
ATCACGGCTA
GTAATCGTGA
GTCAAAACTI
TTGCATTTAC
GAATGCTI'GA
CTACACCGCA
TTGATAATAT
AGGTCATGAT
TGITTI'CAT
GGCGTGATGT
TAAAAGAGCA
CTITAATAGA
T1'GGGATCGC TGATG3rTT
TAGCCTI'TGT
ACATCAATAA
ATATITTCAT
TGGCATAGTC
CATTTATC
TI'TAGGCTrG
CAGCCAITITG
GGTGCTGCTT
GATCTATCCT
AATCATGTT
TAA.ACACTTA
T1CCAAAATC! GTITrTGCTC
AAACTATTTG
AGAAAAGAAA
120 180 240 300 360 420 480 540 600 660 720 732 0 INFORMATION FOR SEQ ID NO:1179: i)SEQUENCE CHARACTERISTICS: LENGTH: 487 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc feature LOCATION 1 .487 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1179
GFFI'ATGGCT
GCGCAAACAA
AATGAGCATG
GGCGAATGAA
TrCTATI'TGC
CTI'TATTTTA
CGTGAATTAC
TACTTI'rTA
CGCCATT
TTTGGGCTTG TGTITTTGTGC GGGCGTITCA AT1'TAGACAA ATFITI AGGCC TGTTCATGCT TCTIGGGGGC GCTA'ITGGGG GTCTATGCCT TGATCTI'GCA GCGAGCAGCA GCGTGCTAGG TACC TrTCTG GCTTGCACAG TACTTTTI'GG TAGCGATACC
TAGGGATTTA
AACCATI'CTT
CACAGCCGGG
GTGGGACCCT
TTTGCGTT
GTT'FrATTCG
CTATGCCGCA
TrI'CGCTCTC AG TI'GGTT
TCCAITAGCG
AATTTCTTAG
AAAGAAACT
TTAGGCTCTC
GTTTTAATGA
GGTGATCCTT
GTATCTTGGC
TG L=ATr=
CTATCAATGA
GTGGGGTGTG
GGGCGTTGAT
AAAATTGGCC
CTTATTITGG
TGCCGATCCC
GTATTTCAAA
INFORMATION FOR SEQ ID NO:1180: SEQUENCE CHARACTERISTICS: LENGTH: 486 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc feature LOCATION .486 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1180 *eO.
a
CGATATTCCG
GGCGAGCATG
ACTCAAAAGT
GATGTGAGTT
AAAAGCGTGC
AGCAATCAAA
GATITI'GCAG
AACATCGCTA
AAAACT
ATCAGACGAA
GTAGAGGCTT
CTTTAGCCGA
CGCAAATGAA
AAGAAACTTA
GCATGGACGA
AAGTGGAAAA
CGCATGTGAG
TCTATTAGcc
TGCGGTGGTG
AATcAATTCC TCTCAATrCG
CGAAAAAATG
'ITACGCTAAA
AGTGGCTTCT
TGGAACGACC
CTAAATGCTG
GCTGATGAAG
ACTATCATGG
CAAAAAATGG
AG7=CAATT
TCCGGACACC
AAGACTTGG
ATGAATI'rAG
CTATTGAAGC
TI'AGGAATT
TGA'FrGTCCA
AGCGCTTGAG
TAAGCTCAGT
AAATTGAAGC
CTGATrCTTC
ACAAACAAGT
CGCAAGGGCC
AGCTGGGCGC
AGAAATCAAT
CGATATGAGT
CGTTTTAGAC
TATGGTAAGC
AGATATTrA
GAATITGTTT
INFORMATION FOR SEQ ID NO:1181: SEQUENCE CHARACTERISTICS: LENGTH: 183 base pairs TYPE:. nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. l 83 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1181 ATTTGTITrAA AACTTAATCA GGGGGGAGTTI TATCAAAAAA, GGGTTIGGAIT GTI'AAAGGTI' TCTGTGATCA CGGCGTGTTT TAATAGCGAA AAAACCATI'c AAGACAC CAT TCITTCCGTG CTTAATCAAA CTrATAAAAA CATTGAATAC ATCAI'ATAG ATGGGGCTAG CGCGATAGCA
CTT
INFORMATION FOR SEQ ID NO:1182: SEQUENCE CHARACTERISTICS: LENGTH: 1992 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAIAE/KEY: misc-feature LOCATION 1. 1992 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1182
C.
C C C C C. C
C.
C
C
C
C C *C 4
C.
C C CC.
AATCATATTG
AACAGCAGGG
CATTTCAAGG
GTCAAAGAAA~
TTCATITAG
TTGAGATTGA
GGGAGTAACC
TATTACAGGA
TTCAAGGAAA
TI'CAGTAATG
GTGCTTTTGA
GTGCCTAAAG
GAATACTTGG
CTAGGCAAAA
GACAAGGTCT
ATGGTGTTAG
TI'GGAAGTCG
TCTAGCGACA
GCGATCAATA
CAAGACACCA
GCTGAACCCG
TGCGTGGCGT
TGAAAGAGAT
TI'AAGGAAGT
TGCTCCCTQA
CCAATI'CGCA
CGCTITTACG
CTITAGTGCA
AA.ATGCCTAA
ACACGCAAGA
AAATCACTAA
GCGCGAATAA
CCACTAATGA
ATCCCTTTAG
TGATTGTGAT
TTTAAAAGAA
GCAAAGTGTT
AGACACCAAA
TGTCGCTGGG
AGATARCGAT
AAAAGCGATG
CGGGGCGGAA
AGTCGTGGGG
AAACAGGAGC
AAGCTTGCAA
AGTGATGGCT
CCATAAGGAG
CGTGGCGTGA
AGCGCTCTGC
TTGGAAAACA
AGAGAAATCA
GTGAGCATGT
ACGATCAAGT
AAAAATAAAG
GTTTAT=GGC
GTrCTGATGA GATrrATTr
GACAAATCCA
ATITTAGAAA
AATTTAG
AATTGGATGA
CGTTTIGTGG
CITITAATGc
TTCTTAAAT
TCTAATGACG
GCATITrAGG ATrCAATGCA
CTI'ATACGAG
AAATCCAGTT
~AAAGA
TGATGGAAAA
AAATI'TCTAA
TGGATATrCT
TTTTCTITTC
TAATTGGCGT
TCACCGAAAT
ATGGCTCTAA
CCG=rGAAAC
TCGCTFI'GAT
TCGTTGCAGC
GAGCGATCGT
TATTGAACAA
AATI'AGGGCG
GGTGTCCTTA
AGATAGTTTG
CAT=GCATT
GTTAAAAAAC
CAGAGAGGAT
CCCGTCATI'A
AAGCTTGCCT
TFI'ACCACTA
CATTrGACAGC
TAAAGGTAAA
TI'ATAAAAGC
AGCGACTTTA
CTTTAAAATG
CATTGAAAAA
GAGTGCTATC
GAGCAATCGT
TCAAGCCCAT
CATGCAAACA
GCAAGCCGTC
GCGCATCACG
TCATGCACTA
AAGCTATTCT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 CAGAAAGTAA AGACAATCTI ATGAGCAAGT GGGATCGGTG CC?1'AATCAT AGCGATCACT TTTCTAGCAC CTrrGTCTCAT TIAAATI'GGT TCAAGCGCGA AAAATATCTT GCAAACCCAA TTAAAGTGGT TTCAGATGTG CAAGCCCTCA TTI'TAAAGAA AAAACCATGC AAGAAGACTG AAAGCGGGGA ATITI'CGGT TTGAGAGACG cGCTAATGGA AGCATTTTCA AAATCITTGA TICAAGAA AGCGTGGGAC TCACATGCCA
GGCTTGGAT
GCTTTAGGGC
GCGAACGATA
CAACACAAAA
GGCGTGAGCT
GAAATCATIA
GCCGCACGAG
CTCGCTGAAA
CAAAGCATrI'
AACGCTTCTA
TCTTTAGAAA
TTAGAGGGCG
AAGAAATCCA
GCGCGAATT
GCCTGATGGA
CTCAA.AGTGA
GAGATAT'GC
CCGGCGAGCA
GGACGCAAAA
CAGACACGAG
TTGAAGCCT'
TCAGTCAAGA
GATCCAAAAC
AAAAATGCTA
AAAAGAATGC
AACTTCCAAA
AGCCATGATT
CGATCAAACG
TGGCAGAGGC
ATCCCTCAGT
CGAAAGCATT
AAGATCGGTT
AATTGACAAA
GCTTCGGGTA
GAAACTTCGT
GTGCAAAAT
ACGATAGAAA
GAACAAGGGA
AATCTATTAG
TITGCGGTGG
GAGAT1'GAAG
AAAAACCAGG
ACTGAGGGCA
GTCTCTAACG
GGGTGGAATT
CTAATTTrC
TAGAAAAGGC
ATATCACCAC
AAGACA'ITAA
CCCTAAACGC
TGGCTGATGA
CCAATATTAA
TI'AAAGAAGT
ATCTAAAAAT
ATATTTTAGA
GGTTACTAAC
CAAPLGATCTA
F1'CAAACTCC TTCCATT1CAA
AAGCATTGTA
TGCTATTGAA
GGTGAGGAAG
TATTCTCGFI'
AGAAGAGATC
CGCTAGCGAT
AGATGTGAAT
1380 1440 1500 1560 1620 1680 1740 1800 1860 1920 1980 1992 AAAAAGCAGT TT INFORMATION FOR SEQ ID NO:1183: SEQUENCE CHARACTERISTICS: LENGTH: 1275 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1275 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1183 a.
q 9' a.
C. a 1 5 S. 5* *5
CGTGGTGAAT
TCTAAGGTI'C
TTAGAAGGGA
AAGGAATTGA
GAAACAAAAG
ACTCCAAAGA
GITCAAAACA
AATAAGGAAA
ACCAACAACA
CCTATCACGC
GCTAGGGATC
CATGTAGATG
GATTTAGACC
CAACTTAAAG
GATACCAGCT
ATCCCCACAG
GCTATGGCAG
ATGAAAACCC
ACGCCCGTTA
GGTAAAAATG
GAATCTAAGG
GCTATITTGA
TATI'ATFIAT
GGAAGCAAGA
AGAATAAGGA
CCAAGAGAAA
TCACGCCTCC
ACGCGCCAAA
CAAGCCCTAG
CCC'ITGAAGA
TGTATCAAAT
GTI'IGATCGC
ATGACAAGCT
ATTTCAAACA
AGCATTTAGA
CTGAAACCAA
AAATAGAAAC
ACCCTAATTT
TAAACCCTCA
TGAATGGGGG
AAGTGAGCTr
ATAAGATTT
AAGAGAAATT
TGGGGTGGTI'
GTCTTCITTG
ATI'AAAGAAT
ACCCAGAGCA
TAAAATCAAA
ACCTGAAGAA
CTCTCAATTC
TAAGGTCGTA
CCAAGAAGAG
TGAACGCT
AAACCAAGAA
GATGCTTATG
AATGCAAGAA
AATGCGCGAA
CGTGCGCTAC
GGAAGTCCCA
AATCGCCCAA
TGGGGGGCAG
CAGTCAGGCC
AGAAGAGCAT
GGATTGATGA
TATGCAGAGC
GATAAAAAAA
AAGGATI'GA
GAAGTCCATC
GGGAGTAGTA
AAAGATACAA
AATTCCATTT
GGGGGCATTT
CAAGAAAAAT
AAAAACCAAG
ATGGCGATGA
GCTGAGGGGC
TI'GT1'GCGTA
TATTACAACA
ACTTCCACCA
GGGGTGAGTA
GTCTITATIT
TTCATCACCT
AAGCAAT1'CA
TFI'GAAAAAT
GGAAAA'TT
CTGATI'CTAA
TCCGCCAAGA
AAAATAAAGA
ATGGGGACGC
AGGGCG?1'CA
CCCCTCAAGC
ITGGTAATCC
CATI'GCTI'GT
CTAAAGTGAG
AAATTGAGCG
TGGCGCAACA
ATTATAAACT
ATATIGCT
AACACAAGGA
ATCAAGAGGA
AGGCCAATGA
CGCATGAGCA
TITATATCAA
TCGCCCAAAA
TGCGCGTIAA
TCTTATATT
AGTGGAAGCC
AITGAAGAGT
AGAAAAGAAA
CAAAAATCCC
AAATCAAGGC
TACTGAAAAA
TAATAACGCT
TAATGGT1'CG
TAAGGCTCAA
C?1'AAAAATC
ACAAGGCATG
CTATAGAGAT
CACGAATGTG
GCAAI'CAGT
TTTAGAAAGG
AAAAATAGAG
AGGCTCTI'C
GGAAAAAAGG
AITrAGTGGAA
GTCTAGGATI'
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1275 0 be 4 GTGATGATCA GAGAG INFORMATION FOR SEQ ID NO:1184: SEQUENCE CHARACTERISTICS: LENGTH: 1008 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1008 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1184
ATTGTGCAAC
TI'CATTATCG
AACAAAAAAT
'ITAGACGAGC
TCTAAAGCGG
AAAGATGAAG
TATTTGCAGA
GAAGCGTTGT
GAAACTTTGG
CTCTA'TrAA
AAAGCGTCGT
CTTTITrGGC
GATATGAATA
TCTCAAGGGT
GCTCTATI'GC
AAACAAATCT
GATATGGTGc
ACTTCAATTT
CTCTTGTGAT
TTTTGCAAAA
ITITAAAGCA
ATGTGGAAAT
AAAAAATCGC
AAACAAAAGA
TGAAGCTTr
AATGTTTGGA
TGCATrAAT
TAGATTTGAA
AAGAAATTGA
TCCCTGCTTT
TGCTI'TTGGA
ATAGCCCTAT
TI'CCTFI'TGA
'ITAAAATCTC
CCTCTATAAA GATTCTrI'AT TTTATTAGAA CAGGCTAGAG ATTCGCCCAA AATCAAAACG TGCTAAAA'rr TCCAGTrGA GAGCATTGAA ATCTTAAAAG TGTITTAGAT TTAT1'GGCTA CACCGTGAAA GAAAITTGC GCATGCGTAT GAATTAGAAA AGAAITAGAG GTGCCTAAAA AGAGAATAAG GAAGATGCGG AAAAATCGCT CTGAATCACT TACAACCGAA CGGCTAGAAA TATITTAGAA AAACATGCCC TCACAAACCT TGCCAAATT AAAAGCGAGT CTGACTTrTG.
AAGCCATAGG TGTCCTGTGT TAAAAAAACG CATGCTATGG
TFI'CTATCGC
CGTATTTCAC
CCTATGCGAG
TGTrTAGC GGCTrTTGAA
AAAATTATIT
GC TI'TCCCC
AAGATTATTC
TI'GAAACGAT
CTAAAATCTr
TAAAATCGCA
ATGTGATCGA
TIWICAGGA
TI'GAA'FTAGA
AATACCGCTG
GTACCAGTT
GAGTGGAT
TTATTCACT
CCGAAAGAGA
CAGCGAGAAT
TAGGGCGTAT
TCGCCCCTTA
TAGCGTGGGG
AAGGAATGTG
AAAGGC'TrA TAAAAA?1'AC
GCATGTTTCA
TGATGAAAAT
TCTTT1'ATGG
CATCGCGCGA
GGTTT1'ACGC
CAAGCATI'GC
AGCGTTTATG
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1008 U INFORMATION FOR SEQ ID N0:1185: SEQUENCE CHARACTERISTICS: LENGTH: 765 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 765 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1185 ATTAGAGGCG cAAAAACGGG TCAAAACGAC CACTTAAAGG GAAAAATGAT CGCTCTCAAA ATAGCCCTTA TGTAACGCCT GACAACCCTr ATCTAACGCT TTAGGGTATT C !AAAGA CAAGCGTTTA TTGGAGCAAG CCTTAACGCA AAGCTCGCTT TAAACAATGA GCGCTTGGAA TITTTGGGCG ATGCGGTGTT
GAA.AAACAAA
AGAAAAAGCT
TAAATCATGT
GGGCTTGGTG
120 180 240
ATAGGGGAGC
AGGGCTI'CTA
GAT1TI'TGC
CTGTCAAGCG
GTGCGTAAAA
TGTTTATGG
CCCACTTACC
CTATACAT'C
CAGCAATGCG
TGCTATACCA
TTGTGAGCGC
GCGTTTCTTC
C'ITI'AGGC
TCATACAAAA
ATTATAAAAC
AATTACTCCA
AAGATAAAAT
CI'ATCAAGC
TAAATI'CTAT
GCATGGTC
TTCTGAAGAA
TTTAATGGCT
TITACTCAAT
CGCTITGCAG
AGAAAAAGGC
GTATGCGACC
GCTTCAAAAA
CAATACGATG
ACTAAAT'AG
ATTTCTAAGG
GGGGTGTATT
CGTGCTTACA
GA.ATTGACCC
CCCGATCACC
GCTAAAGGCA
CTI'AAGGAAG
AGGGCAAACT
CGAAAGCGAT
GGAGGGAAAA
TAGAAGCAGG
AGCGTTI'GGA
AAGCGCAGTT
ATAAAGAATT
AGAGTAAAAA
TCAA
CTCTAAATTA
TGCTTTACAA
ACCCTCTATT
GTTAGCTAAG
TF1'GGAGCAT
TI'GCGTGATC
TGAAATGGCT
AGAAGCCGAA
INFORMATION FOR SEQ ID NO:1186: SEQUENCE CHARACTERISTICS: LENGTH: 429 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .429 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1186
C
C
GCGCATCAAT
ATTGGAATCG
AACAGGAATC
CTGGTGGTGG
ATCAAGCTTG
GAAGCTI'ATG
GGCCGGTIAG
AAAAAGGGC
CATCTCGTGG
CTGCGC~IrrL-
AAGCCTCTAG
GCAAACCCAA
TAGATFI'TAA
AAAATTIAGA
ACTCTI'TGAG
TGITAGCATG
AAACGGCGTI'
GGATITGAGC
CGAAAGCTAT
GGGCGAAATC
GCATTTGGGT
CGCTI'GTAGG
ATTTTAGCAT. GCGATGTGGG ATCTTGCCTT TGGAAGCGAT GATITATI'GA GAAAAAAAGA GCAGATACCC ACGCCCGCAT GTTrI'TATCA ATGAAGATAA
AAGAAAAATA-AGCGGATCGC
ATTTTAGAGC GCTAITGCCA
GTI'AAAACGC
TI'TACGCCAC
CATI'CAAGTG
TGAGCATT
TI'CTAGCGTA
TACCAAAGAT
GCAGGTTTA
120 180 240 300 360 420 C S S.
S
*5
S
INFORMATION FOR SEQ ID NO:1187: SEQUENCE CHARACTERISTICS: LENGTH: 1731 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1731 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1187
AAGAATGAAA
GTTGATTT
ITGATCACCG
CAAGGGGGT'
CAACACCTCC
CCTAAAGATA
AGTAAAGTGG
AACATCAAAC
CCCATICTTA
GAAGTCCCTC
ACTCAAATT
AACGTGAAAA
TCCAAAGAAT
AATAAGATCG
GTCAATGCGG
AATGTCGTAA
GTTGGCGGTG
AAAGAGCCAG
NI 7ATCGAGA
GATGGCAAGT
AGCGATGAAT
AATAGAGGCG
GACAACGCCA
ACGCCTITAA
ATCGTGCCTI'
TCCATGTTTG
AAAAAAGTAG
GAAATIATT
CTCTTI'AAAC
ATI'TTATCAA
TCATCAAGCT
CTITACTCGT
ATGGGG'FTI'
AGCAAAACCA
AAGTGTATGA
GCTI'TGAAAT
TCATTCGCGC
AAGCCAATGT
CTAGCGCTI'C
TAGGGATrAA
TCGTGAATGA
TAGCCTI'AGA
TCAATATCTI'
AGTTrGATFI'
GGAGCGAGCA
TGCCGGGAGT
AAAAATACGA
TCAAGGGCGA
ATAAAATCC
CGCTI'AAAAA
ATGATGTGGC
CTTTGAGCGA
TCAAGTATAT
TCAGCGAACG
AAGAAATGGA
AAGATCAATI'
TAGAAAAGAT
TC'FTAATCAA
GGTTTAATA
CAATAAAAAG
GTITTTATTG
A TrGAAAGA
AATCCCTTAT
AGAAAGGATC
CTTrGACACT
CATI'GAGGGG
GCATATTGCA
AGTGATGCTC
AAATTTAATC
AAATGGCGAA
GCAATTGCGC
AGCCCCTATT
CAGCCAAAAG
AAATITAGAA
TGTGAGCAAT
AAAGTCTCAA
GTTTGGCACC
GCTCGAAGAC
AATCAACGCC
GGTGAGTAAT
AAAAATCATG
TTTGGTGTIT
CATGCTGGAA
CGAAGAAGAA
AGGGCTIAAT
TAGAGGA.ACC
AGATGAAATC
TTGGATTTAA
cAAAAAATCG
CTCTATCCTT
TTGGATTCTA
AAiAGTCTI'AA
ACTCTGGCTI'
AAAGACTTTG
GAATTGTCGC
ATCCCTAAAG
AAGCTIAAGC
GCTGCAGCTG
TCAATAGGCG
TACAAACAAA
GTGGGGGGTA
AAAAGCACCA
GAAAAAAAAG
ATTGGGCCTG
AACACGACCA
TTAATGCGTT
GGGGCAAACG
CTAGTCAAAC
TTTGAGTTA
CATAAAACTC
ATAGTGTITAT
GTGGTGCCTG
GATGAGTTGA
GCAAGCTTI'A
CITAAAGAGC
TCTI'CAGACA
AGGTATTATT
CCCTGATCGC
TTAAAGAAAA
GCGATAACGC
AAGACGACAC
CTCAAGGGAT
GGGCGACTGA
GCACGATTGA
ACAGCGTGTT
CTGACATGAA
TGCCTAAACT
AGGGCGATAT
ATITTGAAAA
AAAACAAGGT
AAGAGACTT
AAGGCGCTCC
TGCAAGGATT
ATTATGAAGT
TGAATGCGGC
CITI'AGAATA
AAGCCATT1GG
ACCCTATGGC
AAAAAATCT
TCATTTCTA
ATGAAGATAA
ACAAACTCGG
GCGAAGAAGA
GTCCTGATGA
GCGCGAAAGG
GCAACGGATr
AGCGGGGGTT
AGACTACGCG
CTrAATCTTA
CATTCTI'GTC
CCCTAAAACG
TTTI'GATCAA
AAGTTTAAAC
TGTGCCTAAA.
GCTITCACCC
CACGATAGAA
ACTAGAAAAC
CATTFI'AGAA
GGTCGCA.&GG
TGATCCCAAT
TAAAAXACAA
GAAGGACAAT
GGGTAAAACC
GGTI'GTGGTG
CGACCTTIA
TGATAATCAA
GCCTATGAT
AGGCTCA'TT
TAAAAAAGTG
GGAAGTGAAA
CGATI'TGAGG
AGTAAGATAT
AATCGCCACG
T
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1731 INFORMATION FOR SEQ ID NO:1188: SEQUENCE CHARACTERISTICS: LENGTH: 597 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: -misc-feature LOCATIONI .597 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1188 S S
B
AAATGGTGCG
CGCCTI'ACC.A
AACCATAAAG
GATT1'CATGT
GACGCGGTGA
GCCCAGAAAT
ACTAATGAGC
AACACCCTTT'
GAATATTGCG
GTTATTGTGA
AAAACCATCA
TGATCCAAGA
TATAAAGG
TEATCCCCCA
ACCAAAAACC
TITTAGAAAA
TAAAAGA7TA
CGAAAAACCC
GCGGAGGAGC
TGCT1'TCGCT
AATCGCGCAA
TTTTTA
AGCGGATITA
cTrGTTrGTT
AGGGCAGGCT
CCATTI'AAAA
GTI'AGGCGTG
TGCAGTTTGG
AACGGTTTGA
GTI'AGAAAI'
AAAAGCGGCT
TTACCCCAAC
CAAGGGATAT
GAAATGCCTIG
GATATI'ATCG
ATFI'TATCTA
TITI'AAGCGA
GTCTGGTGAT
CTATIGAGTAG
GCCTGAATGA.
TTAATATTCA
AAATGAAAGA
CTCAAGAAAA
TCCCACGAAC
ACATGAAAAG
CGCTFI'AACC
TGTGAGAT1'A
GAGCGACGGC
AAATITrATA
TGAATT'A
GGATAAGCTT
120 180 240 300 360 420 480 540 TAGCTATGAA GAAGCGTATC TCAAATTTGG TTAGAATACG AGCTG 1TGGG TAAGATTAAG CGCATCAATC ATCTCGTGGT GTTAGCA INFORMATION FOR SEQ ID NO:1189: SEQUENCE CHARACTERISTICS: LENGTH: 828 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 829 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:ll89 0 0 0
S
0.*00 o.*t.
AGGTTAAAAA
ATGAGTGAAA
TrAAGGCArI'
GGCACGGACA
AACCAATACA
GGGAGCGAAG
AACTTCGCT
CACCCTCAAA
TI'GAGCTATI'
GAAATATCGC
CTCACTAGCT
TTGGGCCAAA
GCCGGCGCGA
GCTATCATGA
TGGCAACCAA
AAATCGCCAT
TAGACATTGA
AGCAAATCGG
TCAATACCGG
AAGCCAGGAA
ATTrAGGCAA
CCATCGCCTI'
TCCCTGATGA
CCCAAGTGGT
ATAAAAI'IGA
AGAGTGCCAA
TTAAAGAAAT
GAGATTTI'AA
GCTI'ACCCCC
TTTACTCATI'
CTCTATI'ACA
CGCGGCGGTT
CGGTTTAGAA
AGTGATGGAC
AATCAAGCCC
GATITI'GGCC
AATGAAAGCC
TAAAAGGGTT
AGTGGGCGGC
AACCACGCTC
GATGTI'CACT
AAGTGGGGGA
AAACAAAAGG
CAAGTGGGCG
GAGATI'TCTA
TTAGAGGAAT
TACGCTAGGG
AAACTCACTA
CAACAACTCG
CACATIGGAAG
GAGATTI'CCA
TCCACGGTGT
TTGAGAGCGG
GCTCGCAT'G
TTI'GAAGATA
TTAAAAAAGA
CTCAATTAGA
AAGACACCAC
AGCAAATCGT
TTITI'GCGAT
AGCTTTTAAC
AAAGCTI'GCA
CTGATTTICAT
CCCCTAATGC
TTAGAATGGC
TAGAAAACAPL
TGGCTGAAAT
AAAGCGTGGA
TAGCCAAACT
i:TGGTCTT
CGAACTTTCC
AGGCGAGATI'
GCAATTAAAC
CTTTCAGTCT
CAGGACTA
AACGCAAAAA
CATrAACGAA
GGCTGAAACT
GAXITTAGGC
ACTAGAATCG
CTI'TAACCGC
TAACAAACTC
AGACAATT
120 180 240 300 360 420 480 540 600 660 720 780 828 INFORMATION FOR SEQ ID NO:1190: SEQUENCE CHARACTERISTICS: LENGTH: 582 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO- (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .582 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1190
AGAAGTTTGG
AATTTTrTA
GTGATAGTGG
TTGGTTATI'
TCTAGCTCT'
AGTGCGCGCA
CAAATCAGAG
CTCTCTAACA
GATTCTAATG
AAAAAACAAG
GAAAAGGGCG
GCGAAAAGAA
CGTGGCTTi'
TAGTGGATAT
TI'ATTTGGCT
AATGCTACCA
AGAATTTAAA
TCGCTGAAGA
ATGAAAACCA
AGGAACTGAA
ACcAATGAAc
TGAGCGCTGG
TAGGTTAAA
F1'GGGTGTAT
TTTAATCGCT
ATI'CAGCCAA
AAACCGCTCC
AATCATTrCA
CAAAGACAAG
AGCTAGAAAG
AAGAAAAATA
CTGTTAGCCC
AGCATTGCGT
AGCGATGTGC
TTACTAATCA
AAALATGTG
AATCGCAAAG
AAAAAACAAG
CTTTCTA.ACA
GATAAGGGGG
GCGTAATTTC
ACAGGCACAC
TITCTAITT1'
GCCAGT=I
AGTGGGGCGT
CGTTAATCCA
ATGCTAAAAA
AAGAGTCCCA
T1'ACCGAAGA
AT
TGGTTTGATG
GAGGGGGTTT
AATCACTCTG
ATTGGACACT
GATTGTTATA
AAGAAAAAGG
TTTTGAAAAA
CCACAAAGAA
AATGATTCTC
120 180 240 300 360 420 480 540 582 INFORMATION FOR SEQ ID NO:1191: SEQUENCE CHARACTERISTICS: LENGTH: 1617 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) AN~TI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/ KEY misc-feature LOCATION 1617 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1191 e..
U. U U a
CTTATGGATA
GGGATTTCAT
TTGAAGATTG
GAAGTGTT'G,
TITGAACA
GTGATAGAAA
GTAACCGATG
GTGGAAGTGG
CAGCTGAAAC
TATATCCGTG
CGGCGTCTTG
GAATTCGAAA
ACAGACACTA
CCCAT1'GCCA
TTIAGTAGAAA
TTAAGCTTAA
CTGGATACGC
TTAGAGGGCG
AAAATTGCG
GGCATGCAAT
TCTACGGAA7I
GATCAAAACC
TTAGGCGAAM
CCTAACATCA
TGGGAAAATA
GAATTAGAAG
TTGCAAAGCC
GAGCCAAATT
CTI'CTTCAAT
ATCCTTATAT
T1'ACTAGCGA GGAATTTAhC
ATGAAAGGAA
AAATCAAAAG
GTGGAACCGT
TGGAAT1'ACG
CCACTAGCGA
GCGTAACCCC
AGAAAATCGC
AAAGCATTA
GACGCTI'TAA
AAATCATCGC
AAGAATCTTA
AAGTCAATAT
TTGATGCGAT
CCATTCAAAG
TAGCGATCGT
TI'AACCAACG
ACCAAAAACA
ACGAATGCGA
TATATTCGTT
CGCTACGCTT
CAATATTGAT
TGGCGCTGAA
GAGGTTGAAT
AGGGGAATAT
GCGCATrAAA
GGGCGATATIG
GAATA&AGCA
ACTAAGAAGC
TCAAATCAT
TTTGAGTI'GC
CGCATGCCCT
TTTAATAAG
TCCTAAACAC
TAAATCCTTG
TGAATGGCTG
TTTAGTGCCG
GGCTAGGTI!A
TGAA'TFTGT
CTGCGAATAC
GGTGCGCACC
AATCATGCCT
ACAGGGGGCG
TTGCAGCAT1'
CCAGGCACCA
ACGGATITAG.
AATFI'CACTA
TTAGGCAAAA
AGTGCGGCTA
GAGGGCATGT
CTCATCAATA
AGACCCACGC
TTGGCGCGAT
GATGTGGAAC
ATTCTTTI7x T
TTGCACCCTA
AAGGTCAAAA
ATGAAGCCC
GATAGCGAGA
GGGGGCTTTG
GAAAAACTCC
CGCAATGTFI'
CCTGTGGTGT
TATAATICGC
AATAGCTTGC
TATGAAATCA
TTTGGGGCGA
GTGCAATI'CC
T1'CATTAAGA
TG'ITAAGCTC
GCAATTACCA
1'GAGCCCTT.
ACATCGGGCA
CCGGGCAGAT
CCATTCAAAT
AGGGGTI'GGA
'TrTATGTGGA
TGCATGTAAC
AACACTCCGT
CGCCTAAGCC
AAGACAGCGT
TGCAAGAAGG
AAATGGCGGC
TTGGTITTGT
TAATCCATGC
ATTTTAATGA
GAGAAAGGGG
CCTITT1AGG TAGGCT1'GAA
ATTTGATTGA
CTTTAGGAGG
TAGAAAAAGC
ACCCCAAATA
ATCATrTGAT
ACCCGGAATI'
GCGCTCTI'CA
ICTAGGGAAA
GGTrI'CTATT
AGAGCATGGG
'FrATGAACGC TrTTCAAGC
CGTCCCCCAT
TTTTA.ATC
ACCGATCCGC
CTTGATGCCC
CCAGGAATTA
TTTGGATAAA
GATTGTAGCC
CATITTTAACC
TTGGAACACT
GGGCAAGTAT
GGGGGCGCAT
AAAGACTGAT
GAI'GAGGGC
GATYITGTTTG
AGGGGCTAAC
AGATTrATG
CACCATGCGA
CTATAAAAAG
CCGCCAAGAG
TGAAGCGATT
CACCTCCAGG
TAAATCC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1617 AAGAAAGACA CCGCCATCGT AAGGCTTGAA AGTGGTGGGC ATCACCCGTT CTTTGTGGGG CTAACCCTAT TA'TTrGGAT INFORMATION FOR SEQ ID NO:1192: SEQUENCE CHARACTERISTICS: LENGTH: 1107 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION I1.. .1107 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1192
S
S S
S
S S
S
S S *5 555.
*555
S
555
S*
S
S
ATATGGCGTG
ACGAAGGCTA
AGCGCGTATT
AACTCATGGA
CAAAAAACAG
CAGCATAAAG
CAAATCGCTG,
GCGAATGAGT
GGGAATGTTT
TITGATGAGA
TTCCATCCCT
CAAAGCGATG
GCGTTATrTGA
TATATTGATT
GCTCAAAGCG
TTrAAAGACA
GATGGTAAAG,
ATTATCCAAG
'TITGATGAAT
GATGTGGAAG CCATGACA ATTACGAAAAL CACTTATI TI'CCGGACAT TGATGAAG AAGAAT1'GTC TAAAAACG AAGCTTI'AAC GCACAACA CGAGCGAAGA ATTAAAAA AGATCAACAA ACGCATITP TAAGGGATAA GCGAGATC TTAAAAGCAG CAT1AAAi GCTATAACCT TAATATCG TAGTGG ETAA AGAATCCC ATTITAAGCT CACTAAT; ATGTGTATAA TGACGGC~ TGTTGGATTC TTTTGCT.
CGAGCCATCA TATGAGC CGAATrACAA TATCAAA] AAATCGCCAG GAAAACC2 TCATITAACGC TAACACCC TA TTT CACAG CGAGCTT
CG
C
;AA
C
;GG
;AA
CT
GC
kTT
.AT
GTGCATGATG
GATACAGAGT
AGCCTTITTA
AAAGACTCCG
AAAGACACCA
GTCA ETAAAG
GAAGTGGAAA
T1'AGAGTTTC
CATICGCTCA
CATGGGTCA
AATAAAGGGG
ACCGACAAGC
ACGGGACTT
GGCT1'GATAG,
GAGCCTGTGG
GGCTCGTI'TG
GCTATCACGC
GACAATCAAG
AGTTTGTT
TITCGCAT
CGGATTTGCA
CTCAAAAACA
GAGAGAGGTT
AAGTCAATAG
ACAACAAGAG
AT'FTGCGAGA
CAGATAAAGA
ATATCATTGA
GTTTGAACCA
TCAATCAAGG
TAAAGGGCAA
AATCCACGAA
AGTrI'AATAG
ATTTAATCGC
CCATTACAAC
ACAACAACAC
TGCTCGTTAC
AAAAGAAGCG
AGATTAT1T
GGCTCTCGCT
AACGACCTTA
CCTGGGTICT
TTAAAGCAT
GCTITTAGGG
CTCAGCGGAC
TGGCTCTAT'
GGTI'TATTTT
GAAAGTGGGG
GTGCAAGAT
TGCGATTI'AC
CGATGAAGCC
TTACAACACC
CATGAACGAC
CGAAAACGAT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1107 INFORMATION FOR SEQ ID NO:1193: SEQUENCE CHARACTERISTICS: LENGTH: 813 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genoraic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature, LOCATION .813 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1193
AAAACAAAGC
GGCGCG'ITTG
GGAGAATCGG
AGTAGCGGCT
TTAAAACCAC
TTAAACGTGT
GTGTIACGCT
GGGCAAGCCC
TI'AGATGAGC
CT1'GATTA
ATAACCAAAC
GAAAATCGGC
TGCCATTATG
TFI'AAGCTTG
TCGTTTAT
ATFI'GAATAT
GAGCGGGTAA
ATAITGAAGC
AACAGCGAAA
ATCAAAACAT
TA.ATGCGTTT
AACGAGTCC
CTTTAAACGC
TCAAGCGTGA
TCGCGCGAAC
TTITTTCAAA
AGGTCATTCC
ATTI'CATTCA
GATAAAAGCG
AGACI'TAGAA
AAGCACGATC
CAATCATTCA
AATCGGCTTT
CGCCTTTGCT
AGAAAACCTA
TTTAGCAAGA
CCTAGATAAC
AAATITAAGC
TTTCCTCTTT
CCGCTI'ATTG
TCAAACGATC
AAACAAAAAA
CGGTTTAAAA
AT1'AAAGAAG
ITACGCATTTI
GTATGGTI'AG
GTGTTTCAAG
CACCCTAAAG
AGCCAGCAAA
GCTTI'AATCG
GCCTI'AAAAA
GTGTI'ATTGG
TTAAACAATG
GTAAAACCTC
AGTTTGCCCA
AACGCCTTr
CAGAAGTTGT
TAGCAGGGCT
ACACTCAAAA
ATTACGCCCT
ATAAAAATAA
AAATTCCCAA
CAGCCAAAAA
ACGAGGTGCA
TAAGTCATGA
GCGTTATTGA
TCTTI'GAAGA
AAGATTGTCT
AGGATCTAGG
CGCTT1'ATTA
TGAAGCGGTG
AAAGATTI'
ATTCCCTCAT
AATCCACGAA
ACTCTCTGGC
TCTATI'GCTT
ACAAGGTTTG
TCCAAACGAA
TCCTAATCAA
TGAAAATAT
GAACCCAACT
120 180 240 300 360 420 480 540 600 660 720 780 813 9* *9 9 9* 9 S. INFORMATION FOR SEQ ID NO:1194: SEQUENCE CHARACTERISTICS: LENGTH: 213 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE:.
NAME/KEY: misc-feature LOCATION I1.. .213 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1194 GGCTTATCCG CTACTAT'CT TGGTATGTGG ATTATGTCTT CACTTTCTAG TTCATTCTTT CA'FTCGCTCT TCTTCATCAA ATCAAACCCT GGCCAACTCT TAAAAGGITG GGGTTCAAAA ATCTTTCA TAAA.TAGAAA GTTTGTITTA GCACAGTATA ATCCTAGCGT TICAATI'TTT AT TITTACTCA ATAGGGTGTT TGGTGTI'GGC GTT INFORMATION FOR SEQ ID NO:1195: SEQUENCE CHARACTERISTICS: LENGTH: 225 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori 0.0 a (ix) FEATURE: NAME/ KEY misc-feature LOCATION .225 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:l195 ATICAGCGCT CGCACCAGCT C ITAATTTG CAAGAAAAAA CACCAAAAAA ATATCTIAAA TATTGCTCAA AATGACATCC GTGGTCTrTl' CTATGTTAGC AACCCCTTTI ATI=AAAAT T1TATTTTGC ACCAAAAGAG CCAAGAAAAC GAGCCGGCTA AAGGGATTCT TGGTITITA ACCAGCTCCT TATTCTCATG ACCTAGAATC TATCGCTCAA
AAAAA
INFORMATION FOR SEQ ID NO:1196: SEQUENCE CHARACTERISTICS: LENGTH: 35. base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 351 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1196
S
S..
S
S. 5555 *5 S S
S
GGCTTGATGC
GCGCTCGCTT
GTCGCTATAG
CAAGACCCAG
ATGATCTIAC
CGAGAGAGCA
GCATIATCAT AAGGTTACTT CTI"TGATGGG GGGGCTrGG GGAT'TTTTGT GTTGATCTTG AAAAACGAGA AGAATACATA AAGACAAGCA AAAAGAAGAG GGCAAAAACA AGACCITAAA TCAT1TAAAA TGAACGCTTT TATGCTTTCA ATGGCGAAGG TITGTTrrT TrATCCGCCC GAACGGCTTA AAAAAAACCA CAAATGCGCC TCTATCAAGC GAACAAATGA AAAAATACTC
TTTAAAACTC
CTCTGAGATT
TGTGAGTTTC
TGAGAGGAAA
CAAAAAAGAG
A
INFORMATION FOR SEQ ID NO:1197: SEQUENCE CHARACTERISTICS: LENGTH: 327 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION l...327 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1197 AGGAAAAAAA TGGAAATCAT TTTATrAATT GTTGCGGCGG TTGTGTTGTT TTATTITAC 860
AACACCCTCA
GACTTGAAAA
ACCCAAATAG
GATAACGCTT
CAAAATTTAG
AAGAATATTT
ATGACCCCTA
GCGCGTATAT
TAAGAACGCT
GCCAAAGAGC
GAAAAACCCC CTAAACCCTA TTIGCTGGTG CAATCTACCC GCCCTFFTA AANTTAG ITTTTATC CAT GAATTGGAGC
TTCTCAA
AAACCAAAAC CGAAGAATAC CCCTAGACAA AITCAACCAA ACATI'CAAAA A.AACGCCTTG AGCCCTTAAA CAGCGAACAG INFORMATION FOR SEQ ID NO:1198: SEQUENCE CHARACTERISTICS: LENGTH: 1629 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1629 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1198 9* .9 *9 9 9 9* 9. 9 9**9 *9*9
C,.
9 ATGCCTAATA ACGCTI'TATT
AAAGTCATI'
CAATGCTTT
CCCAACAAAA
C'TACCTTAA
TTTGAAAAAC
ATTI'CTAGCA
TTATFI'GAAA
TC'TTATTAG
CAACAAGGCT
AACAGCGGAG
AAGCTITI'AG
GGAACGCTT
CAAGACATT
ACCCACTCTT
GACCACAAAG
AACGAGCATIG
CCTAAAAACG
ATGCTCAGTC
AGCGGGGTAA
ATI'TGCATGC
CAAAAAACGC
TACACCGAAA
GAAACT1'CC
ATTACAGAAA
GAGACAATCA
AGCCTT1'G
AGGTTI'QAG
GCAAGGATGC
TGTATAAAT'
CGATACGAGA
GCGATAAAAA
ATFLTTTACGA
ATAATGCCGA
GCGTCTCACA
ACAhACTCAA
ATGACTTT
GGACATACGC
TGAATAAACC
TAATGGCATI
CGCAAAAATC
TAAGACACGC
GGAAAATGGA
CCGAGATTTC
ATAAAAGCAA
CAAAAGGTAA
ATAATAAGAA
CCAGTCAGGT
CAAGCGCAAA
ACAAAAACAA
AAAATAAAGC
AAAATI'ATTC
GCCAAGCGGA
ATGAAAGCCA
GCAAATCAAA
TGGITI'AGCG
CTTATGCGAT
CTACAAAGAC
ACTCCCCAAA
TAACGATI'A
GCTTF1TAAC
ATACATTAAT
AAATTTAAT
CGCCCCCATT
CGAATACTAC
CACTCAAAGC
AGCCCACCAA
CTTAAGAATG
CAT1'GAGGGA
TTTCATCGTG
GCAAAACAAA
AATGCCCATI'
GGGAGCTATA
TGTCCGGCAT
TT'ITGCCAAC
GGAAGTGATC
AAAACGCGC
CCCAAAATCG
TCTAAACCCC
GTTTGAAAAC
AAAT'rrGCAA
CAAGACACCC
GGCGACGGCA
AAGTTTGAAT
TTAACGAGG
CTCGCTTATG
CACCTAAAGC
ACCAAAAGCA
GAAGGGTCTA
TTCAAACAAG
T1'TGAATACT
ACCCCTTTAA
GTCAAAATCT
ATAGGCACCG
CTCAAACTCA
AACACTITGA
AGTAACCCCC
AACGATTT
TACACGCTCT
ATCGTGCCAA
TTAGTGGATG
ACCGGCACTA
TTGATTGACG
TTAAGACCAA
GAT1TTTGCG
GGGCAGTATI'
TGATGCAAC
CAAGAGATIT
TAAGTCTCAT
ACGGATACAA
TCTTTI'TTGA.
AAGAAAAAGA
ATGAGCIT'
TAGATGCTAT
CGGATGAAAC
AAAGGGCTAA
C?1TT1AAA
TACTCAAAGA
GCATCGCTAG
ATGATCCAAG
ATTCT1'GCAC ACCTGATTr
CTAACCCCTA
CTTTCAAAT'
TCTTAGGCGT
TTCCAGCA.
CCGGATI'CAT
A.AAGGCTCGT
ACGTGAGCAT
CTTCCAAACT
GCGATATGGA.
CTCTGGTTTC
TCACTATAGA
AATATICAAG
TAGAAACTTT
TGACGATI'A
GATCATCACG
ACAAAAATTC
ATATITTI'C
AAACTATCTT
TITCAATCGC
CACTATCGCC
TTTTACAAGA
TITACAAAAC
TrACAATAAT
CATCATTGCC
CGCTGGCACA
CCTTTATGCC
AAACGACTTG
CCACTCCAAA
GGATTICC
GCCTAATATC
TI'GCCTGAAC
TAGTGCTAAA
TTATGGGGTG
CATCTI1TT
CGGCGAAGAA
TT1'GATUI1'A
TITTGATGAA
AGACACGAGC
CGAACTAGCG
AAAAGGGGTT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1629 INFORMATION FOR SEQ ID NO:1199: SEQUENCE CHARACTERISTICS: LENGTH: 576 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA {genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .576 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1199
AAAGGGGAT'
AGCGCAGAAG
CAAAATAACC
AAFI'GTCAG
ACTAAAGAAG
CTFFI'ATTCT
AAAAAATGCA
CTAAATI'TAG
AGC-TTTGTITA
AAGCGAAGAA
TCATGAAAGA
AATrTTTTAAA.
TTAAGAAT
AAAAGATCTC
CGAAGTrTA F1'GAAATTIGA
AAGATCATGC
ATGAAGAAAA
TGGATGAACA
TAAATITTTAG
ACAAGAATGG
AACCTTACAA
AGACGCTGCA
TAGAGCGATG
TTCGCAATGC
ATITAAGAAT
ITrITATTTA
GATCGCTCTA
TTTGTITTCT
CCCTCTI'GCA
GATTTAAGCG
ACAGAAGTGC
AAATTTGCCA
GCTTACGCTC
GAAATGGCTT
TTGGACGCCA
AACAATCTCA
GCCCT?1'CGC
TIGAACATCT
CAACCC
C TTT ATI'TGA AAATAAAGAA
AAGAATITGA
ACACTCTIAL
AATTACTI"I'1
GTGCAAATAT
AAAAACAGCT
TAGAAAAGAA.
CTGTGGGAGT
CFFI'ACATAG
GAACGCTTAT
ACATTACGAA
TGCCAAGAAC
CCAACAACAC
CGCTTTCATI
AAAGCACACC
GGGTGCGTTT
AATAAACTT
120 180 240 300 360 420 480 540 576 INFORMATION FOR SEQ ID NO:1200: SEQUENCE CHARACTERISTICS: LENGTH: 465 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .465 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1200
GCCAAAGAGC
GAAATCGCCG
ATGCTAT1'AG
GTGGGGGCGT
CACTI'CAATI'
CAAACCCACA
TACCATAAAA
ATCGCCCTCG
TTCTCAATGA GCCTGTGGAT AAAAAAGAAA ATTTTGAATC ACCACACGCA TGGAGAATAC ACCAAACGCC TGAAAT1'AGT CCTATGCTGA TGGGAT1'TTG GACAGCAAAG AAAAAGAAI' TITTGCAGAT AGACAATCAA GATTTAACG AGCTTTATGA CAATAGAAAT CCCTATGTCT TTAGAAGAAG CAAAAAATCT CCACCATGCA AGAmTAGA?. AAAAAAGCTI TGGATTTAAG TGAATGACAA CAAACGCTAC AGCGAACAAG ATFTTATCTC CTTCCCAACT 'FITAGAAAAT GATTTAAAAG ACTCA
CTTATGCCAA
GGAATrrCTT
GTTTTTAGAT
CAATTTTGAA
TrII'GAAATC
CGCCCCCTAT
TFI'GAAAAAA
INFORMATION FOR SEQ ID NO:1201: SEQUENCE CHARACTERISTICS: LENGTH: 1215 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 1215 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1201 0 *0 0* 0**e ATGCCCTTIT TAAAAGCCCT AAGCGI'ITTA GGGATAATFI CTCAATACGC CITI'AAAAA.
CACACGCCCA CGAACGC FFI ATGGCTAAAA ACCCCTTGAA CATTATITAA AATCTCAAAA ATCTCAAACT TTTTAGATAA ACCATGATTT ATGGCGiTiT.-.
CGC4TCCATT CGCTTTATTT TTTGCGCGTI' ATGAAGAT1T AACCCTAATG AATTGAAAAT CTAGAAATCA TGCCCTATAA TATI'ACAAAC AAGCCTTAAG AACACGCTTA AAAACTTACC GCCCCCATFI' GCGTGGTGGG GAAAATGAAG AAAAAT1'CAT CATGGCGT1'A AAGTGGATT TrAGAAAGAG CCCCCCTAGA GCTTGATT TAGCCAAAGA AAGCCCTTTG AGTATAGAAT GGGTGATG AGCGA AGCATCT1TT
AGTITTTTI'C
TTACCAATTG
AAGCTACCCT
TAATCCCAGA
CAACCACAAA
TCATCAAACG
AGACGGCTTG
GTTI'GAAGAA
GATI'AAAAAA
GGATTTG
AAGCGCTTT1'
GGGTTGG=G
CCTATGCCAA
TAATGGGCCA
CATFTITTCA.
TCAAATAGAA
AGACACCCCC
AGCGTTGATG
ACGCAGCGCC
GATGCGCCCT
AAATCTTATC
CTTTT1'GAAA
AAACATCAAA
TGGTCATTAG
CTCCCCCTAA
cCTI'GCTCTT
TITTTGGCTA
AATI'TAGACT
GGGGCTAAAC
AAACGCCCTA
AATTTGCGCA
AGTTTIGAAG.
ACCCTAAAAA
AGCCTGGATT
TGCGGAACCG
GTGGAGCGCA
TI'AATGGGCG
TFI'ATGCGTG
TTTTGTGGGC
~TTAGAAAA
ACCCTAATCT
CAAACCATCT
TGATAGAAAC
ACAATAACCA
CCCTTAAAGC
TAAAGAAAT'
'FITrACAGGC
TGTTTAAAAT
'FITTrATTCA TCACGCATrC
TGCGAGAAAA
ACGAATTGCT
CCAAACCCAA
TATTGI'AGA
CTTTAAAGCC
TAGACTATCT
.CTAACATGCT
GGGGGAGCGC
AATGCCGGGG
AGAAAfTrTCA
GTTTAACGCC
TAATCTCT'A
CGCITTTAAC
CCTCTCTTTA
CACGCATGCG
CCTACCCCCT
TCAAAA'ITAC
CAGTTGCTAT
AGGGTTTT
TTFTTAAAG
CAITCAA6AGC
AGGGGTAAAG
AAAAAT1'AAC
TTTTTTAAAA
T'ITAAAAGCG
TAAGGAGGT1'
CAATCCTAAC
TTGCGCATAT
TGGCTTTAGC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1215 .0.
00. INFORMIATION FOR SEQ ID NO:1202: i)SEQUENCE CHARACTERISTICS: LENGTH: 1239 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geriomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE.
NAXE/KEY: misc-feature LOCATION .1239 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1202 AAG4GGTTIAG
GGCGGCGCTA
ACCCCTAAAG
TCACGA'ITAG
TCTI'CAAGAG
GGTTTTAAAA
AAATACTATA
GGGGCTACT
ATCGCCCACA
CTTTTACACA
GATGAAAACA
AACCGCCTTA
TCCGGAAGTC
TTCATACAAA
AATAACAAGA
GTGCGTTI'G
CAATCCATGC
TCTAATGCTI'
ATGCTCCCCA
ATAACAGCCA
CTACTCCCCC
GTGAGTGA
CCCCACCTAC
ATTTATCCAC
GGTTTAAATC
CTCCCATAGG
GTAITATCCC
AGGATAACAT
TAGGTCTATT
CACTI'TCTAT
AAATCTTAGA
ACAAACCCTA
TCCCTAACGA
AGCCACCCAA
ACAGAGATTA
TGTTATCA
GACTTCAAGG
AGGAATATAT
GCATGGCATC
TACCACCTAT
TTATTAAAAA
TACTC'ITAAA
GTGGCAAACA
CAATAACCCC
'TI'ACAAGGG
ATGCTCTTGT
TTATGTGGCA
TAACAAAAAA
TTCCAACATA
CCAAGTI'AAG
TTI'AGATCAA
GCTTCTrI'AT
TCAAACTAGC
TF1'TAAAGTC
AAGTTGTCAC
TAGCTCTAAT
ATATGATATT
GGCTI'ATAAT
ACGCAGTI'AT
TACGAGAGCA
TAATCTATTA
CAATCAATCA
ACAACAAGTC
TITIGTIAA
AAAAA'ITATG
CGCTACAT'A
GTGTTGCTCC
ATTGCTGAAA
ATTTATTTTG
GGGGGCGGAA
ATACCCCCCA
AAA6ATAGAGA
GAGCAATACT
GGCGGGAAAA
AAAACGCTAG
ATATACGAGT
AAGXTAGG
GCAATAAAAT
AAAAAGGCAG
CAAAGCATGC
AAAGGCTATG
AATTITATA
CTACTTAA
CTTAITACGA
ACAACCATAA
TCGTCCGTTT
TGAAATTTTC
GGGAACTAAT
ATAAAGAGGG
GAAAATAGTC
TGCTI'GGATT
CCGCAGCATT
CATrAT
CACCAATCAA
TTACTTATI'A
AGAAGTITCA
ACAACAAAAA
AATCAATGAG
TGATTTI'A
TAAAGAATTA
AACTTGGATT
'F1ACATI'CGT
TATATCAAAA
AGCTGGATCC
CGTATTAAAT
AAAATATCTT
TI'ATTCITI'A
AAAAAATATC
CAGAGACTT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1239 AATTATGT1'A CATATAITCC ATGATGGACA AATACGGAGA GTTGCCTTAA GTAAAATTAG CTAAATTCAA AACCTATAAA TCACTAAATG AAAATCATAT CAAAAATACG AAAAAATCGC ACCCAAACCC TAACCGCGCT
AAACCACAA
0 0 ~0 0* 0 0* *0 0090 INFORMATION FOR SEQ ID NO:1203: SEQUENCE CHARACTERISTICS: LENGTH: 591 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/=E: misc-feature LOCATION .591 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1203 00
GGTGTAACTT
AGCTI'GAGCG
TATCAACAAG
GACCTITATG
GCTAGGGTGT
AATTTGCTCA
TTCGCTCTAG
GATGTCAATC
GATCGCAGTG
GTAGGGCTTA
TAATTCAACA
CGAGTTTAGC
GTCGTTATGG
GTITGAATT
ATGGCTITITr~
CCTATGGCGG
GTCTCAT'GG
AAACCAGATI!
CG'ITTGAAGC
TCCGCTACTA
AGAAGGAI'T
GTTAGCTGGC
CCCTI'ATAAC
CAAATTAGGT
AGATTGGrr
CGGTGGCGAT
TGGCGTTCAA.
CCAGTTCI'A
GGGCGTGAAA
TTCTI'GGTAT
ATI!ATGATI'A
GAAGTGAATG
AGCAATTACT
TTTGTAGGCT
AACACTTCAG
TI'GATI'GTCA,
TTAGCCGGAA
TGGAATFI'AG
TI'CCCTATGG
GTGGArI'ATG
AAAGAATTGC
GGTTTTTCAT
CTGATTGGCG
TTOCCAATAA
GGACTGAACA
ATCTCATI'CC
ACACTTGGAT
GCGGAAGAAT
T1'AATCAGGG TCTTCACT1TT TrIGTATITTTA
GGGTGCGGGT
TCATGGCA.AT
ATGGTTTGGG
CACCAAAACC
TTCGGATAAA
GTTCCCTI'AT
GCGTGTTGGG
TAGCAAAGAT
C
INFORMATION FOR SEQ ID NO:1204: Wi SEQUENCE CHARACTERISTICS: LENGTH: 1098 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (gerlomiC) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .1098 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1204 ?ITCGCTIAIT A'FTrCTTTAA AGCACACITI' ATATTGTTAT AAGAAATI'AG ACATGCCCGT ITrm,1TAAAA T1'AATGATT TTAATGTI' A TGATAGGCAT GTGCTCG'ITT F1'GGGCTTT TATTTTG'C TGGGTCTTIC TCTrCAACCG CCATI'GTGI' GGAAAGAGCG CGGTGGGGAT AT TTGACGA TTCTAGGCAG AITTTCAGCGG GGA'ITATI'IT ATCTAGAGC AAGCGAAAGA AT'G'ITTGCA GCGCGGCGGG TTCATrGTGG GCATGGCGAT GCGCAATTAA AAAACCTCFI' GTGAGTITCT TCATGGAGAA ITI'AAGACTI' TTATCATTI'A AAAACCGCTC TI'TCTTTGGC GCGCTCGCAC CAGCTCTT
AGCAAATCGA
TGCCGGCT'A
TATCATTGGC
TAATTTGTTG
TGAG'TrAAT
ACAGGTIGT
GCCCATTTT
GAAA LTCTTT T1'TGATTI'C
TAAGGATTCT
AATTCTITI'A
CACGCGCTTG
GTTGAGCCAT
TICTAAATCG
TI'TGGCCCTT
ATITCTTTGTC
TGCGCTATI'G
GCAAATI'GGG
TCCTACTGGG
TGGCTTGCTG
TACATTTGCA
TCTGATATTG
'TTGACAAGC
TTATGCGCTI'
TCCCTI'GTTI'
GAAGATICCA
CAAGATATTG
CATGTCAATT
TTATTGCCTG
CCTGAAA.TCT
TTTTGGGT
CGCTATAA
TTCATTA
GTCATCTI
CGTITTTTI'A
GAGTTCTT
GAAAGGTFT
TAGGCITTTGG
CAGGA.ACGGT
GTGAATTTGG
TCAAGTCCAT
TAATCGCTIT
TAGGCATGGG
AACAGCTTIAG
CAGCCATI'CC
TGCTCAFI'CT
AAAAAAAAGG
T1'ATAGGCAC
TTTCTATGTC
TCAATGTCCA
CGATAGGGAT
TACTCATITT
GAGACGCTAA
TCGTGATCT'
TATGGTAAAC
AATCTTITTA
CTI'AGCGGCT
TATCGTCFI'
CAAACAAGAA
T1'ATTGGGG
GCTITCACTC
CACGCCTATG
CATGCTTTTA
TAAAACCCT
GGCTAATCTC
GGTITTAGTG
TTrGGGGGCG
AGAAGAATTC
GCAGATTAAT
AGTGATGAGT
AACCGCCATC
TrI'AAATTCA 120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1098 too* 00 0 t0 .6% to. 0 INFORMATION FOR SEQ ID NO:120S: (i SEQUENCE CHARACTERISTICS:.
LENGTH: 726 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .726 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1205 TG1ATGCG TGGGGGGAGC GCTTGCGCAT ATAAGCCCTI' TGAGTATAGA ATACGCAGCG CCTII'GTGG GCA.ATGCCGG GGTGGCITA GCGGGTITGA TGAGCGATGA AATTTATT'G TGCGCTTTAG ATTGCGCTTA TATCAAAGGG T1'AAAAAGC ACGCTCAAAA TrICCTAT1'AT 865
GGAGATGAAA
TATGAAACT'
CATTATACC
GITAGCCTCA
CGCATTAAAA
AAAAATCTGA
AAGCAAGAAG
AAAACCCCCA
CTAATCGTIT
ACGCCT
AAGAGATI'GA
ITAGCGACTC
AGCCTAAAAA
ATCACTCTCA
GCATGTTTAG
TCGTTII'AA
CATTTGAATG
CTATAGGCAT
cATI'GCATCT
CACCTCATCT
GCTT7"TFTG
AGTCTATAAT
AGTGAAATTG
CCCTAGAAGT
AGAGGATT
GGTGGATAGC
TTTAT1'TGAA
TAAAGAAAAT
T'rAATCAGCG
CTCTCTAAAG
TTAAGCTATG
AAACAAATCA
AATCATGCTA
r1'CACGcATT
TI'GAGTGGAT
GGGAGTGTCG
GAGCTGACGC
TAGAGGGTAA
AAAGGATTGA
GGGCGAAAAT
ACAAACAAGA
AGGATTTAAA
TAAACACGCC
TI'TGCCAAAC
CCCATATCT'
TTI'TATCAAA
TGTTGAAGGT
AGAAGCCCTT
CAAGCACGCC
CGCTATCCT1' AAAT?1'ACAA
TI'GTAAAACC
AGCCAGCGCT
ACAAAGCGTT
TTCTCTCAAA
240 300 360 420 480 540 600 660 720 726 INFORMATION FOR SEQ ID NO:1206: SEQUENCE CHARACTERISTICS: LENGTH: 957 base pairs TYPE: nucleic acid STFRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NANE/KEY: misc-feature LOCATION .957 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1206 a
A
C A
ATCCTTCTTIG
~1ITATCAA
ACGCCCACCA
ATAATCAATA
TTTGCCT1'GT
GCTGCTGCTA
CCAAAAGACG
CAAAACGCCC
GATGAAAAJA
AGTGAAAATC
GCTATGGCTA
TTAAAACTCA
CATCAATI'CA
AAAAAAGACA
TTGAATTAAA
AGATGAGGGT
ACAA6ACCGCC
ACTI'CAATCA
TAATCGTAT
ATCTCACGCG
CTATI'AACAT
CTTTTGATI'
TAACCCCTTT
TAAAAATGGA
ATCCTAAACT
CTCCTAGTCT
TCGCCACCAA
AAAACCTCTC
GTTACACCCT
T?1!AGAGTGG
TCAAACTT
TTTAATCAAA
TTTCTCAAAC
CGCTTTAAAA
TAGCTTTAAT
ATTCATT1'CA
TAAAGAAGAA
TTCTTTAGAA
AGCCCCTTAT
TAAATCTAAA
AAACGCTCAA
TTATI'TCATC
AAGATCGGTI'
AAPLTATTGGT
AAAATACAA&
GGGAGTCTA
GCTCTAT'AG
GCCCTTGT'A
TCTTCAGGCA
GCGGATATTG
GTCTATGCTA
ATTCTTAAAG
GGAAAAGCCA
ATCATTTATG
ATAGGCTITG
ATI'GATAAAA
ATITTCTAA.
TAAATACTGA
TTTITAAGAT
TGAAAAACGC
CGCAGGATFI'
AAGAATI'TCA
AACTCTACGC
CTAGACCCAA
AAGGCGTGTI"
ACCCTAAAAT
GcATG4GAAGT
GCGCTTCTAT
GAGCGTTATC
CCCITTTATAA
TAGCCAAAGT
ACGGCTATAT
AAGATTTAAT
TAAGTGGGAT
ACAAATAGGT
TTTCAAAGCG
AAAAATCGCT
AAAAGAACAC
TCAAATCGCT
AAAACTTTAT
GGITTATGG
TAAACGTATC
TTCTCAAGCC
TTTIGATCGAT
CCCTATI'GAA
TTTTAAAGAT
TGTGGAT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 957 CAAGCCTISAA TCATCACTAA AAATGGGGCT AATAACCCT TTTITATI'CA GCCCTAAAGC TAGAGCTATC TTTAAAGAAT INFORMATION FOR SEQ ID NO:1207: Wi SEQUENCE CHARACTERISTICS: LENGTH: 684 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO 866 (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .684 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1207
AAAAGGCGAA
TTGATTACCA
AAACGCAATC
CCAAGCGTGC
TTrITTACAAG
AGCGTGATTT
CCCACTTCI'
TTTGTCCTAC
CACACTATAG
AGAGTGGCTA
CAATACGCCT
AATAAAAAAC
CAATGGATCA
CCCTI'ATTT
TITTAACGAG
TAGGGTTITA
ATGTG21'AAA
TTI'CCTTGCC
TAAAAGAAGC
TCCCTAACAT
GTGAATTTGG
GCATI'ACGAT
TAACGCTCAC
AAAGCTCGTT
TGAGTTTI'G
ACTCCCTATA
CT1'AACAGAA
TCTTCTI'TTA
TGTGAAACTC
CTTTATGGTA
CAGTTATAGC
CAAACCCAGT
CGTGGTGATG
CTITAACGAA
GCTI'MTAGT
ITI'A
ATTACCATGC
GGGATTT
ACGCTTGTGT
ATCTTrCGC G'TTrAGTT
AGCCCTAT'A
TI'GGGTAAAG
GTGTTGATGG
ATGCTTGGGG
GCTGAAGCAC
TTTAGCCTCT
GI'ITGAGCT'
TAGGCTATT
ATATGCCTTT
CTTCT'CTIT
TCCAAGGGCT
AAAGCGCGTT
GGGAATACTA
CTATCA'TAC
GTGATATATT
TCAATI'ATI'C
TGTI'TGTTAC
TTCTTIAGCT
TTITAAGCCTT
AGTI'TTACCC
TTTGGGAGCG
TATCTTAGGG
AAT1'TCCTTG CACCC 11
AACTT'ITATG
AGGGGAAACA
TAAAGCCCAT
CCTATTTA
120 180 240 300 360 420 480 540 600 660 684 .a a. INFORMATION FOR SEQ ID NO:1208: SEQUENCE CHARACTERISTICS: LENGTH: 561 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .561 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1208 S0., 0. 0 AATI-I-rxIT T1T1'TArIGG
AGCACTAAAG
CCTAAACAAG
ATCGCTTCTA
TTAGATGAGA
ACCGATGAAT
GTGAAAAACG
GGCGAAAGCA
TI'GGAGAATT
TAGTTGGCTG
CGGTrCAGAC
AGCCAGCTCC
ITATrrl'GA
TCGTGCAAAA
TTGGCTCTAG
CITTTAGTCAT
AACCCAAATG
TATAATGAAG
TAGTCATAAA
TGCGCCTGTI'
AGTGGTTGAA
TTTTGACAAG
AGCTAAAGAA
CGAATACAAC
TAAAGGGGTA
CGTCCAAAAA
AGATCTTCTG
ATGGATAATA
ACTACAGAAC
GAAAAGCCGG
TATGAGATCA
AACCACATGC
CAAGCGCTTG
GAAAAAGATA
ACTAGAGAAT
TATTTAGTT
AGACTGTGGC
CAGCTCCAGA
CTA'ITGAAAG
AAGAATCCGA
AAGTGCT=T
GCGTTAAAAG
TPATCAAAAC
GT1'ACAGAGA CTrGGTAGCT
TGGCGATGTG
GAAAGAAGAG
CGGGACTATC
TCAAGAGACT
GGAAGGCAAT
GACTFIGAGC
CATCAGTr
AAACAGAAGA
120 180 240 300 360 420 480 540 561 GTGGATGTCA AATTAGTGAA G INFORMATION FOR SEQ ID NO:1209: Wi SEQUENCE CHARACTERISTICS: LENGTH: 603 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .603 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1209
AAACGAATCA
AAGGAGTGGG
GTCATCGCT
GTCGCTITT
AAAAGAGAGT
TGGGTGAAAC
AGCGTTGTGC
AATGTTTT
GATTGGGTGA
TITGTTCTTA
TTT
AAAGAGGGTT
GTI'ATCTTAT
CCATTTTGAG
TAGGGAATTI'
TTT TAAAGTA
GCTACGCCTT
CTTI'GGCAAT
CCAGTTT.1r
AAACGCTGTA
TAGCGCTT
TTTTATGCAA
TTTATTI'TG
CGCTACCACG
AATAGGGAGT
TTI'CCAAAAG
GCTCATGATT
TGGTUII'AGC
GAAGCGTTGT
TATTCCTTGG
CACGCTTTGG
GGGGCTCTITG
CATAGAAGAA
'ITTGTCAATA
AAATACCCI'
TGCGFIWIfCA
GGGGTGGGTA
ATATAAAAAT
TAATCTrrGC
AGCTTGCTI'
AATATCTCTA
TAAAAAAGTT
GCGTTCTTT
CTI'CGTTTTI
GATAT1'CGCG
AGAGGGC'FIT
TGTAGGGAT1'
AACCATI'CI
CCGCTATCAA
GGCGAGTITG
TGGGATTAAA
TTTIATGGCTr
TCAAGCGAGC
TGTCATAAGT
CAAAATGGGT
GTGGGCGTTA ATCGTGGGGA TGAAAGGCTT TCTCATTACA AATATGGITT TI'ATTGAAAC
U.
U
a. a.
a.
a a a a INFORMATION FOR SEQ ID NO:1210: SEQUENCE CHARACTERISTICS: LENGTH: 1182 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iiij HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINA.L SOURCE ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1182 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1210 GCTAGTI=A ATI'ACAATIT AATTITCTCT TAATCATCGC TCTAAAGGGC TrAGTTGAG CTGGTGGCTG AATACCCAAG CTGTITTAATGTGTTTrI' ATCCTCATGC TTITAGCGTG ATlGAAGC'rT CACTCATCAC GCCAAAAACA ATCAAATTAC TT1GTATCTCA AAGTCCATGC GCGCTAACAA TCATCATrI'A TTGAAACTCC TTAAAGAGCA
TCAAATGTI'A
TCAAAGCTI'G
TGAAATCTTG
CGGCGTI'ITA
AATCGCTAGT
GGGGTTGTAT
AGACATTAAG
TrATTr,=GC
GATGCTGTAT
TITTAAAGAA
AGTCAAA0GC
AGGAAAAACA
CCCCATGCGA
CTCGTGCAA.A
GCGGATTTGA
TITTCGT1TTG
GGTTTGTATA
GAANACAAAA
ATGAT1'ATAG
GTCGTGGGGA
AAAGAAGGGG
AGTCTTAAAG
?TrTAGCTTA TT7TAACCCC CCTTTrAG
TGAGCCGGAA
TGCTGTT1
GCGCATGCTC
AAGAT1TTATC GGAGT1CTT
TITTTI'AAT
ATITTAAAAG
AGCTTAAAGA
CTATGGGGCG
CTTGTTGCTT
TTrGCGTG
GAATI'TATTC
TGATAGTITTT
TAGCGGCACG
CAAGTIA
GGGATCGTrI'
CATGCTCTGT
CCAAAAAAAT
TAACCCCAAG
120 180 240 300 360 420 480 540 600 660
CTITAAAATT
ATGTGGCAAG
ATCGCTTTTC
AAAATCGCCC
ATCCCTI'ATT
TATTGCT1'GG
TCGCTTTTAT
GAGTTGCGTI'
ATCCTCTTTI'
TGTI'AGTGGG
CGTATTTT
AAGTGATITC
TGAGTTCGCT
GITI'CATAGG
GGTATCAATT
CAAGCTGTGT
ACTTCTCACC
TCTITTI'GTA
GCATI'TGATI'
AAAACAAGGC
CATCCTCA'T
TTTGGTGTTG
GGTGTATGCG
CTCCAAATTC
GCGCGTGGTC
CCTAACTATC
TAAGGCTAAG
ACGCCTGTCT
G1'TAAAGAGC
CATTTTTTAA
CTAGGCGTA
CTCATGGTGG
GTTTCTAAAA
TCTGTGCTAA
ATAACCATGC
CCGTTTGATG
TTITIATGAG
AATACCTTIT
AAGCCAAAAA
GCCCCTGT
CGTrIWIGC
ACAACATTTC
TCTI'GTCGCT
AITI'TGCCCT
AG
CCXITI'CCAA
TGTGTTCTAT
TTACAGCCAA
GCTTAGCAAT
TTACATGAGT
ATCGCTCTCA
CAGTAGCCTA
AACGCTTATC
720 780 840 900 960 1020 1080 1140 1182 INFORMATION FOR SEQ ID NO:1211: SEQUENCE CHARACTERISTICS: LENGTH: 261 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 261 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1211 c~
S
S. *S 5
S
555.
S
*55*
S
CGCAGAAATC
CATGCGAGCC
ATCACCGATA
ACCGCCCTAA
GGCACGCAGA
TTACTAGACA ACATGGAAGT GTAAAAAGC GTGAGAAGCG T1'TGCGATAG CGTGAGGAGC GGTAAAAGAT TAGGCTATAC TTGTCAATAT CGGTATTGGG GGGTCAGATT TAGGCGCTT AACGCTACGG CCACCCAAGA TI'AGAAATGC A TGTGTC TTITAGACGT T
TTAAAACG
CAATCAAGTG
AATGGITGC
TAATGTGGAT
120 180 240 261 INFORMATION FOR SEQ ID NO:1212: SEQUENCE CHARACTERISTICS: LENGTH: 222 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1 .222 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1212 CAGCATTATC CTAATAACCT AAAAGATATA GAGATGAATA CAGAAATTrI' AACCATCATG TI'AGTTGTCT CCGTGCTTAT GGGATTGGTA GGCTTAATAG CGTITF ATG GGGGGTTAAA AGCGGTCAGT TTGACGATGA AAAACGCATG CTI'GAAAGCG TGrI'GTATGA CAGCGCGAGC GACTTGAACG AAGCGATI'T ACAAGAAAAA CGCCAAAAGA AT INFORMATION FOR SEQ ID NO:1213: SEQUENCE CHARACTERISTICS: LENGTH: 726 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .726 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1213 *9 *5*S S. S.
S. S
S
*5 *5S* S S 5555
S
*5 S S
S
GAAATGCAGT
GCTCTATTAG
'FrGATTGAAT
ATGCAGTTTG
GTX'GATGGCA
ATTI'ATGTCA
TTAATGGGCG
CTCTTGCCGG
ATGAAGTITTT
ATCGGGTATG
CAGTTGAAT
GCGGTTAA.AA
CCACTC
TTITACATGC
CGTI'CTITAT
TGTTATI'GGT
AAGAAATGAA
TCGCGCTCTT
AAGAGCGTCG
TGTTCTTC
TTITATACCT
TCCTCTACAC
ACTACGCCAA
'FITCTAGCGG
TCCCGCTCTT
GAGCGATCAA
CTTGTTGTTA
AGAATTAGCC
TIGTTGCTC
TAAAGACTTT
TCT1'AATGTG
CATCGGTCGT
CTITTTAGCG
TAA'ITACGGC
GATI'AAAACC
TCCCTTCACA
GCGAGCAGGG
TGGCATGGGT
TATCAAATTG
'TAAACGCTA
GTGATTTGTC
ATCTI'ITTCT
TFI'GGCCGTA
TCGTTGTGCA
ATGATGAGTr
TGGCTCTTTG
CATGGCTGCd GCATCTITTTA AGCGTGGTGA.TCI'ITTCCC
CGTATGCGAT
TTGATATI'CA
GCGTGAATTA
TCGTGGTGTT
TTTTATTGT'
ACGCTTTITG
ATAACAAAAT
TGCTTTTAGG
T1TGATATT TAGC'FrTCTI'
TTATGCGTAT
CATGCTGAGC
CGTCATCGCC
AACCGCAGGC
CCATGTITGGC
ATTIGTCCGTG
AGAAGGGATC
GGAAATCTCG
CTATI'CTGGC
CATITI'ATAC
AGACTGGTAT
AATAGGGATT
TCTAACGCCC
120 180 240 300 360 420 480 54 0 600 660 720 726 INFORMATION FOR SEQ ID NO:1214: SEQUENCE CHARACTERISTICS: CA) LENGTH: 1488 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: CA) ORGANISM: Helicobacter pylori (ix) FEATURE: NAIE/KEY: misc_feature LOCATION 1. 1488 Cxi) SEQUENCE DESCRIPTION: SEQ ID NO:1214 870
AAGAGGTCTC
AGCATITI'AC
T1'CAC'ITCCA GXFF1'TITAG
CTAGATACTC
TTCITAGCCC
TAcTTGTITA
CTI'ATTGGGT
CGCTACGGCT
TFI'GCTATGG
ACCCTATACT
TFFFI'GATTG
GATGTGTATG
GCTGGC'FTTG
GTAGAAGACA
TTATGGCAAG
GCTFI'AGCGT
TTCATGTITG
GAAAAAACAT
ACCCACCCCT
CCTTTTAGCG
ATTCTTAG
TGGCTCGTGG
ATTI'ACACCC
TGCTI'GTL'CT
TTATGTTAAT
CCATGCTGGT
GGTTI1-1CGCG
TGGTTTCAGG
TCTCGCTCAT
TTI'CAAAAGA
TTGTCGCTGG
TAGAAACAGC
TAGAAGCAGG
GCGCGATGGC
TACACACTGA
GAGCGAT'GG
AGGGCAATAA
TGGTAGCGAC
TTTTTTATGT
AAGATGTCAA
GCGTGTTrAT
CCTTCACITA
GGGATGAACG
TAGTGGCGAT
TGT'FTrGGGG
CGGTGGTGAT
CGATGTTTT
AAAACGCCAC
CTGTGTTTAT
AGATATTCTC
GFTGGTGTGT
CAA.TTTGAAT
GTTAGAAGAG
CTCTCAA.AGC
ACGCTTCAAC
CTTTCAGTTC
GCCTITGCCC
GATCAAGTAT
TTTTTACCTG
GGGCATCACA
CTTTAAGGTIT
CCCAGTCTT
TCGCCTTT
TTI'GATCCT
AAGGATGCTC
CCACACTGAA
CATTGGGGCT
CTACGATCAC
CTTGGGCGCT
GAAATTTTTA
GTTAGTTAAT
CAATAAGCCC
CATGCCCATI'
GATGCGAGGG
CACATCTCT
GGGGGGATT
GTGTTFITAT
CAAGAAAACG
ATTGTCFI'GA
GAATTTCAAA
ATGGTTI'CAA
cTTTGTGTGT
TTCACCATGG
CTTACAGGGA
AACCCCATGC
TCTTTAGTGC
GCGAGCTATA
GGGGCGTTTA
ATGACTATCA
GC'ITATAGTT
GATAGCCAAC
TTrGGCCTFI'
CCCTATTCTA
ATTTTGTTT
GCCGI'TGAAA
AGCGCGGTGG
TTACAAACCC
TATGCGGTCA
CTTTI'AGAGT
TTGATAGCTT
TCACGCTCT'
GCATGCTCTT
CCTT"ITIGG
TITTCAGCTT
CCGCTGAATI'
GCAACCAGTr
TAATGGCGTT
GGGCGATGGC
GCTI'GAATCT
TCTTTGCGAT
CITTTCCATAC
TI'TCCATI'GT
TAGACACTCA
CCATCCCTAA
CTATTTCGCA
AAGCGATGTIT
TATGGCTCTT
AATTCAACGG
TTGGGCTTGC
GCGCGTTIAGA
CTGCGTTITA
AAAGCTACGC
TATGrCCAT
TTGTGGCT
TAGTTTTGAG
AATCAACGCT
TITTGGT ITG
GTTTTTAAGC
TTITCTCATI'
TI'ATTCCCTA
TGI'TGTAATC
GAGCGATAAA
GAGCGCGTIT
TGAAGTCATT
GGGCACTATT
CTGGATGCCT
GCCTAAAATC
TACCGCTI'GG
TTTCATTGCT
TTCTGGGTTC
TGTITATrGG
AAAAAGCCGG
CCTTATCAAA
AGGGATCCCG
GAGCAATCAC
TATTTICCGT
TCAAAACGAT
GGCGTTAGCG
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1488
S
S
S
5*SS S
S
INFORMATION FOR SEQ ID NO:1215: SEQUENCE CHARACTERISTICS: LENGTH: 888 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ATI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .888 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:121S
AATCCCGCTC
GGCTCTGTCA
TTGCTCCCGC
CTGTGCATGA.
ATCGCTTATA
GTI'GAAGGGG
TTATI-FrIAC
GGATCGATCG
AATGTGGGCA
ITTGCCACT1
TACATGCTCA
ATCAGCGTOT
TTGATCTITAA
AAGCAGCT
TTTCCCTTCA
TGCTTTCAGC
T1TTTCCTGA
TCATFI'ATGG
GCTC'ITTCTC:
'ITTCAGGGGC
TCGCTGGTAT
CTAAAAGCGC
TGCCTITAAG
ACCCTCTTTT
CI'CATATAA
TTGAAGATT
TTTAGGGAT
TAGAGGTGAT
CACATGGCTG
CI'GCTTI'CT
ACTTTCAGAA
AGGTTTTCTA
GCACATGGGA
GGTGTT1'ATG
CTI'GGAAGAA
TCCTGTITI
CATTGGTTT
GGCTATCATT
AGATGTGT'C
AAACGCTCGT
TATCCTAAA
AGAAATCCGC
CCTI'ATGCGT
AAAATGGGGA
TTAITI'AA
GCCTACGCTC
GTCGTGGTGC
ATGTFI'GCGC
CGCGCCAGCA
GCAGCCTT
GTGGGAGAGT
GCCGGGACAA
TrI'GGCAACT
GAGGTAGGGG
GCGCTTTTAA
TCGCTCCTTT
AT1'CTAACGC
CTTACGCCT
CCCCCATAGC
AAAAAGATTT
?TGGGGTT
ATGGCGTTAT
GTITAGAAAT
'FrATGATCGT
TI'ITGAGCTI'
GCATCA'ITCT
TAAAJLACCGG
TITTAAGCGT
AACCGATIA
TIT1'AGGT1'C
CCCCACTCTA
AT1'ACGCTTC CAT1'GTGGCG
AAAAACCCTC
FrTT11rCAA
CGTCATGGGA
CGCTCGCTT
lTITAATGGCG
GTI'AGGGTI'
ATCAGCGGTT
GAACAACCAA
GATI'ITAGCT
GCAAGGCTTT
ATTGGACACT
120 180 240 300 360 420 480 540 600 660 720 780 840 AAGATAAAAG AGCTCTCT'A TGTTAATAGA TATTCTCCAC ATCTCTTr INFORMATION FOR SEQ ID NO:1216: SEQUENCE CHARACTERISTICS: LENGTH: 1404 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .1404 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1216 a a a
ATTIATTCAA
AGAGGCAT1T
GGAAAAATCA
GGGCGTTTTI'
GATTI'AGGGC
ATCCAATGCC
TTTAAAATCA
ACGCTTI'AA
GCCCTAGAAG
TACAAAATCG
AAGGCITTAA
CACCACCCAG
AACGCTATTI'
TCTCATCATA
CAAGGCATCA
ATCAATACTT
CTCAAAGAAA
GAACAAAGTC
CCTGAAGAAA
GAAGCGCTI'A
GGCGTGAGAG
TATTTAGTCA
TTGCTTGGGC
AAACAAGGAG TCATG ACCCCACCAC TTTAG TGCGAGAATA CGAT TGTI'TGAAGT TTTGA TAATCCCCAC ACCGG CTAATTCCAT CATGA.
CGCTCAATCA AAACC ACGCAAAGCA TGAA CGTATCATCG CTI CCCTGGATrT TGGT ACATTGATTrT TAGCA ACCCTAGCGA AGCG TAATAGGCTI' TGCT TCTATGCGGG CGAT CCCCTTTTGT GATCG TTGGTAAGAC GCTC~ CTAATGCGCA TTTTG GCTATGATGA CGCTC CAAGCGACTI' GGAAP AAATCGCCGT GAGCC AAAACCCGCC AAGCC TGGTTTTrGA ACATC GCCGCTFI'GA AGGC TATTAGAAAA ACTT'
AAAGC
GCGCG
TAGCG
TACT
CGT
.TAAAG
TGATC
ATGGC
.CCT
AAAAC
=~GAT
'AATTA
GCGAA
=TTAT
CGGCT
:TTTAC
ACACC
*AAGAA
:ATI'TC
CcTrr
LAGGAT
GTGTTTGTAG
GGGCTGCAAT
TATTTTGCGG
GGCTCTCACA
TATGGCAAGG
CCCCTAAAAG
AAGGATTTTA
GTGGGGGCGT
TATAGCGATC
TTAAAAGACT
GGCGATGCGG
GCGATTT1'AT
GTCAAATGCT
AAAACCGGGC
GAAATGAGCG
GCATGTTTAA
ATTAAAAACC
GAAAAATTG
CCTACAATCA
GGGCTTATTC
GAAACAACAG
ACATG GACATTAGCA ATGAA AATACGGCTT
TTTTTAGAGA
TTIAGTATCGG
GGCATGACGC
CAAGCGGCTT
CC'TTAATGA
ACCCCAAAGA
ACATTCAGGC
AAACGCCAGA
AGCATTTAAA
TAGGATI'AGA
CTGATGGGGA
TAGAAAAACA
ATAGGAfITGC
TCGCTAAACG
CTCAAGTGAT
ATAGCAATIT
GGCATATCTT
GGGCTTTGGA
TCCCCTATTC
AAATCATTCG
AAGAAATCAT
GCGCAAGCAA.
CGTTAGAATA
ATACGATATT1
CGTGGAGTI'G
AAGGGTGCAT
GAAAGTGTAT
AATAGACAAT
ATACAACGGC
'TTTAAAAAAC
GAAAGTCAAT
AAATCTTAAA
GCCGATTTTA
TI'TTCCTAAC
CATGCGAGAA
GATGCTAAGC
CT1'GCATGCT
GTATAACGCA
AAAAATCAAG
TTTI'AAAGAA
GTI'ATTGCTT
CTACACCACG
CAACT1'ACAA
CAGCATI'GAT
CACCACCCCC
TAAAAGGGCG
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1404 a a.
a a INFORMATION FOR SEQ ID NO:1217: iW SEQUENCE CHARACTERISTICS: LENGTH: 642 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) AflTI-SENSE-. NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .642 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1217
GGAATTTTA
ACGGCGTTGT
GAATTGTAT
GGCATTATCC
ACTTACATGG
GGCGTGAAAA
CCFI'TAAAAG
TTAGCCAAAC
TATAAAACTC
GCGCACATGA
AATTTTGCGA
TGATGAGAT
ATTTIAAAAA
TGTI'GGATAA
ATTGTGCCGG
TTGAGAATTT
AAGCCATITAA
AGAGCGATrI'
TCTCTGTGAT
TAGTGCCTTG
TACCAGGGCT
TGTGGGGCGA
CATTTI'AATC
AAACAAGCCT
AGACAACGTT
GAGAGTGGGG
ACTCATGGGT
TCTAGCGAGC
ATTGAACGGC
GAAGTATTGC
TAACCTTI'AT
TATTGCTAGG
TGGCACGGCC
ACCGGCGCTI'
GATGTTACCT
CAAGCCTATT
GGCATTGTGG
TTGTATCTFI'
TCTTGCGCTI'
TCTI'TAGAAC
GAATACGTGA
GGCGAGTI'TG
ATGCACACCG
GAAGAGAGTA
ATGGCATGGT
TACTCACCCC
TGAAAGAATA
CAAACATGAA
TTTCTAGCGC
ATCCTAAATA
CAACGAATGA
GCGCTGAAAA
ACAAGTT1'GA
CTAAATI'AAA
TC
GGGGCAGAAC
TAAAAAGAGC
CAAGCCTACA
CGATCTTTCA
TTrAGATrl'G
CGCCCCTAAC
AGGCTACGCT
AGGCG'TTTTI'-
AGAAAAGATA
AAATGAAAAA
120 180 240 300 360 420 480 540 600 642
B
*fl.
B. *B
B
B
B
B. B B B. B INFORMATION FOR SEQ ID NO:1218: SEQUENCE CHARACTERISTICS: LENGTH: 1215 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: N)ME/KEY: misc_feature LOCATION .1215 fxi)V CEQUE%'' ThrCrTD'rTTM: SE 1 NO: 121'8
B.
B B
B
GCTCACGCCA
AATGCCATTC
AAACGCTCTI'
TFI'AGCTTAC
AGCGTTAG
GATTTICAAAC
GCTTITGATI
AGCGTCTTAG,
TGGGACGGGA
TTGGAACGCA.
GCGATCAAAG
CTTTTAAAAC
CATGACAAAA
GCGTTTAGTT
GAAAATCTAG
GTGGTGCGTI'
AAACGCATCG
CCTTTTAAAG
GAACAATTAG
ACCGCACCAT
GCCCCATGCG
TI'AATGCGCC
TAGATAGCGA
AAAATGAAA
CCACGCTCTT
'ITAATACGCC
ACGCATTATT
GTGGGGCTTA
TTGAAGAAGT
AGCCTAGAAG
GCGTTCAAAA
AAATTCAAAG
TGGGCGTGGT
CCCTACAAAG
TGAAGGAATT
CTAAGAAAT1'
GGCATGTCGT
CCAAGCGATT
CATCCACAGG
TTTGGI'AGA
CAAAAAGATT
AACTTCTGTT
ACACTTTAAA
AGCTTGCGAT
CTTGTTGCAA
ACAAGATCCG
TGAAAATALG
GGCTAGATTT
ATI'GGTTA
GCATTTCAAA
CGTCGCCACC
GGGAACGATI'
CGATGAGATC
TTATCAAGCG
T1'IAACAGC
GGTGTGCAGT
GAAAAAGCTT
ATTGATGATA
GGGTITTGCCC
TTAGCGCTI'G
CTTTTACTCT
GAAACTTTGA
GAGCATCAAA
GTCCAGCACC
CATTTAAATC
ATTTATGGGG
GAAGAATT
GAAATCGCTI'
GAAGACGAAT
AATTCCATAG
AGTITTTGAAG
GCTTI'TACC
TTTGAAAAGG
TTAGTAGAAA
GGGGGCGTGT
GCATCGCGCA
CCCTTTACCT
GAGCGGAGCA
CGCCTTITT
ATIT'1*TT
ACTACACCAC
ACCATGCCCA
ACCCCTTIAT
CGGAGTGTT
GGCTTTTAGG
TAAAACACCA
TAGGAATT'
GGCGTTTGTT
CCGAGAGCGG
CTTTTGAAAT
ATFI'GGGCGT
TCATTACCGC
TTTGCAACCA
GCGCGTGGAT
CACTTTACCC
AAAAGGGCAT
TGGGGATTTG
AAAAACCTAT
CACCAAAATG
CTFITTAGCG
AGGTATTOTI'
TGTGGGGGAT
GGGGCAAAAA
GCTCAACAAG
TAAACAAATG
TGATATAGTG
GCAGGTT1A
CAAAAACAGC
WTAGAACCC
TTTGATTGCG
ATTGTGC
CAAGCATTI'C
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 cAAAGGGAGT ATFFFF1'CCA CCCCCTAATG ACAGCAGTAT CCCTGTCGGT CAAGCCTTAA TGGCGTATTT CAACCCTACA ATCATCAAAA AAGGA INFORMATION FOR SEQ ID NO:l219: SEQUENCE CHARACTERISTICS: LENGTH: 1338 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1338 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1219 1200 1215 a.
a. a a a a a *aa.
a.
a CGCTTI'GAGT GCGGAGCGAG TTATATGTGG GGGGGC'ITAT ATTAACTGGG ITTrGTGGC ATTACCATTT CAGATTATT ATTI'CAGCIT T1'GTGA'TTT GGGGCTAAAC TCTITGAACC ACGCTGAFI'A TTGTTTCTTA TTGATTCAAG GGCTTI'GAT CATCTTGGAG GGATTGGAGA TCITTTCTTGC AAGGCTCTAG TAT1'TTGGGC AACCCCATAT CCTAAAGCGA CCACTATTGG ATGGGGCIT TAGGCGTTGC AAGATTI'CA TTGTAATGAG AGCGCGATI'T TAGCGGCGGT ACCATI'GCTG AAGATITCTA ATGACGATTT CTAGGC TTI'C GATAAAAACG CTAGCATCCT TI±GG±CTI IWAT±±.
GCTGGCATGC TCTCTGGGGC TIGGATATFT ATGAAATCGT AGTTTGTTI' CTAGCGTGCG ATTGAGAGCT TAAAGCAT
CGACATGAGC
CAATI'CACAC
TAAGCGCTTA
TGAAACGCGC
AATCTTAAAG
GACCTTTGGC
CACCTII'TA
GATGAGCGCT
GGGGATTAAA
CGTAGTCGCT
TTTAGTGCGC
GATTTCTTGG
GGGTGGCTT
ATCGCCATAG
CGCATI'ATA
TTTAGCGATG
ATTTTATr
ATTCAATACA
GGAAGGTATA
TJ2AATCGTGG
ATCATI'AAAG
ATTATTTCAA
T1'CATGTCTA
ATGGTTATI
TAATGGGATT
GCTTGAGTT
CGAGCGTGAT
ATAAACACAT
TTCTTCAGG
CCTACGCTTT
AGGCGGTGTG
TGCCGATCGT
ACATCAAGCC
GCCTIGCTTG
TCCGCTCCAT
CTTTAAT1'GG
TGAGTTTAGA
GGATCACAGG
AACTGCTI'GT
ACGCCCCCCA
TCGCTrFrT
GGGCTGGCTT
ATAAATITTGG
GCGTAGCTAT
TTGAAACCAT
ACCGGGAGCT
GGGCGCACTC
CGCTAATTCT
CTTGCGC ITG
GCTAGTGAGT
AAGCATTGGC
CTGGACGGAT
TATGATAATC
TGAAAACCTT
GGGGITAGGC
TAGAGATGTG
GGCATGCGTI'
AGACCCTGAA
CATTTTATTG
AAGCTCTTCT
AAAATTAGTG
CATTTCAACG
T GGCGCGAGT
CAAAAGCTIT
TGTTGCGTTT
GCTAAAGAA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1338 TrATGTACAT AAATTTGACT
TCAATTGCTC
GATGAGCACG
TGCGACGATT
GG'TFTAGGG
CAGCATCGTG
TAGCACGGTG,
TCCGGGCI'T
ATCAGGCACT
TTTAACCCTT
GCCAGTTCGC
TTCAATAAAA
GTGGCTTGCA
AGTTACGCAT
ATITTTATACG
ATTGTAGCGA
AAAGAGGCCT
INFORMATION FOR SEQ ID- NO:1220: SEQUENCE CHARACTERISTICS: LENGTH: 1125 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .1125 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1220
AATAAGTGGA
TC'IIAATCT
GACGATGAGG
AACACGGAAA
TTAAAAGCCC
CCCATGGATC
CTGGCCTCTC
TTCCCTGTGG
GCCACTAATG
TTGATTACGC
ATTITI'GCAA
TACAGCAACA
ACTCCCCATG
AACGGCTTAG
CTFI'CTACGC
AATAAAGAAG
AGCGC;CATGG
CCCATTGTGG
TTCCCTATAC
TI'AAAGGGGC
ACCACCAAAA
TGAAATACCC
GCTCCAAAGA
TAAACTCCAA
CAAAAACAAC
GCATCACCCC
ATAACCCTAA
AAAACAAGCT
CCA'ITTCTAG
GCATGGGCAA
ATAACAAAAT
GCATTAATAT
TGGGGGAA T
TCACTAACGG
AGGTGACTAA
GGATCAATCA
TGATTAGAGA
CCAGAGAGAA
GGTI'GLITTi7.T
GCCAAAAGCC
CTTACAAGAt
CGCTACCATC
AGAAATGAAT
CCCCCCTAAA
TITCAAGCAA
TGGCATTGAT
TTTACGCACC
CCAGATCGCT
AGCCGTCT'A
GGGCGAATAC
CATGCTCACT
GATTGAAAGG
CCTATTGATT
TTTCTTTGGG
AGTGGTCAAT
GGGGAGTAGG
TGAAGTCATC
GTAGGGGGTI
CCCCTAAATA
TACACF1'TCA
AAAGCCTTAC
TAITCCAAAG
AAGACTIT
AGCCCTAAAA
AGTITCACTA
XITACAGCTG
GGTAAAGTGA
ATCCCCAAAG
CGCFI'GGATA
AACGCTAAAG
AATTTCCAAC
GGGATCACT
GATITATC=T
CAAAT1'TTAA GTCITCA TT GCTGAG'.11IT
TTGCAACGAT
ACCAGCCTAG
CTCAAAACCC
AAGAACAGCT
AAGAGACTTT
CTCCAAAACA
ATTACGAAGA
ACCTTAAAGA
ACAAAATGAT
TTGCGCAAGT
GCTCTAAAGT
TTGTATGGAG
GGGCGGACAT
GCTATGGCGT
CGGCTTTAAA
TATTGCAATT
GAGACAAGAG
CGCCCAATAC
TGAAG
TACAACCI'T
CCTTFI'GAAT
ACAGCCAACT
CAAAGCCGCT
TACTAGCCCT
ATTAGATTTA
AAACCTGATT
AAAAGACATC
ACCCGCTI'
GGAGAGCGAT
CATAGGCTAT
TCGAATCATC
TAAAGGCTAT
GCCGWITACTG
CAACAGAGGC
GATGAGGCAA
CAAGATCCCC
TGACATCTTC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1125 INFORMATION FOR SEQ ID NO:1221: SEQUENCE CHARACTERISTICS: LENGTH: 363 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .363 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1221 5
AAAGCGGCGT
TTAATCAAGC
AGAGCGATGA
GTGTTI'TCC
CTAGGGTTTA
TGGGTAACTT
T1'A
'FITGTATAGG
ITTATITGCA
AATMTTAT1'A
AATCTATI'CA
TCGTI'ATCCT
ACCCTA'ITGC
GATTTFIC
GCCAACCGAG
TGTGGGCTAT
ACGCACTAAA
ATTIGCCGATrr
GCAATTITA
TATGGCGCTI'
CAAGACGCGC
GTTITTAG
AG'FTCGFI'TA
TrAAGTCAT
GCCGTTTTTG
ATI'ATTTCCT
TC TTATGCA
GCATGACTI'I
TCATCACGAT
TTTATGGGGT
GTAGCGTI'AG
AGATGAATTT
AGAGACTAAA
GTGTGCGCG
T1'CGCACACG
TAATGGCATI'
GGTAACT1'A INFORMATION FOR SEQ ID NO:1222: SEQUENCE CHARACTERISTICS: LENGTH: 390 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAIAE/KEY: misc_feature LOCATION .390 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1222
ATGCTCAAAA
TTCATCCCTT
TTTGTGGGCA
TTTCCAGGAC
TATTTTTTAG
TTTGTCGCTC
GCGCGT'FTT
AAAAGATI'GA
TAGTTTFC
AAAAACTGGG
TCAITGCGTA
GTCAAAATAA
TAAGCGC CIT
TGGGAGCAAT
TTTGCATAAA
TATGATCTCA
TAAAGAAGCT
TGAATTGCTT
AACCCATAGG
TATITTGAGC
GACGCTTI'AT
GATTCTATTA
CTTTCTACTT
ATCGCTGCGG
TTTGGTTTTG
GCTAGGCTTG
ATGGCGTTAT
GGAAGCTCT
ACTCTATGGT
TCAATATCGC
GGGCAGCGAG
TGTTTAGCAG
TGCCTTFI'AG
TIITTATTAC
AGATGACATG
ATGGCCTA T
CATTGTGGGG
CGTGTTTTAT
CGAAAATATC
120 2.80 240 300 360 390 INFORMATION FOR SEQ ID NO:1223: SEQUENCE CHARACTERISTICS: LENGTH: 483 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) 9* (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO ORIGINAL
SOURCE:
ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/ KEY misc-feature LOCATION .483 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1223 AATCATIITA ATGGTTGTGT AATGACAAAC GGCCCGTITI' TI~l'CAATI' ACTTGT1'TAT ACCGTGATAG GGCATGCGAT GCGCAQITGT A'rTI'ATCAA GGTGTGCCTC AAAGCACGGC GCTATCATGC ACACGGCGGG GCGAI'ATCT TITT= ACGAC
CTT
ITTTAGGGTI'
AGCGATGGTA
TTTTGTGTTG
AGGGGTITTA
ACGATrrCT
GGAATTTAGC
GGAAAGGTT
TFI'GTI'TGCG
CAGCACC'TT TAGCGGATGT
GCGATGTTGA
GAAGTGGGGG
GTCTTAATGC
'ITATCTTCAG
GCTI'CTATTA
GTGAGCATGT
ATTTCTCAAG
TI'GGCTCGTI'
T1TCAAGGCAG
AGCATTTTTG
TCATTTCTTC
TGATTTATT
ATGGGATCGT
GCATCCAACC
CTTGTGGTG
AGCGAATATC
CGCGATAGCC
GCGCAAAAAA
AGCTAAAAGC
GITTAATACC
TATIGTATAAT
GATTGCAGAG
120 180 240 300 360 420 480 483 INFORMATION FOR SEQ ID NO:1224: SEQUENCE CHARACTERISTICS: LENGTH: 1278 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1 1278 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1224 p
PU.
p p p. 9* PP P
P
U*
P
p.
P
TTTCTTAACA TTAGGGATI'T GCGGTGCTTI TTCTTATI'GC ACGAI"IGTCA GCGCCTTTGT TTGGGCAGAG AAATACTGCA TATGAGGGGG TACGC'FITIT ATAGGAGGCT TTATCTITGC ATTTCACTTC TATATTATT TrGCAAAAAT GCTTAGGCAC GTGGCGCACA CCGAAGCGCC GAGATTTTG CGGTCATGTG TATGCGAGCA TGGGCATFICC GGGGGGTI'GT TGT1'CGCTAA GATG TTT CTG CAGAAGAGCA GGGCT1'CATI' TAGCCTI'GCA CTCGTTAACG GGCTITTAGG, GGGGTGGTIT TAGGCACGCT CAAGCCGGGA TrGCCGGGGA TATATGCAAT TATTGCCTTA AAAGCGATCA TCACCT1TGC ATTGGGGGGC TTGGCAG TIT AAAGCGGTGC TI'GTAGGCAC ATAGGGTTAA GCGCCAAT
GACGATGATT
TTGGGTGTI'
GATTCAAGTG
GGGTTTAGCT
ATTTGGCAAT
GATCAACGT1'
AAAAATCATG
TTCTAAAGCA
CTTAGTCATT
CGTGGGCATG
TTTACCITAT
AATCATITTAC
TGTCAATAT
TGTGGGGGCG
GGTI'GTAGGG
TTTAAAACCT
AATCATAGGC
Trl'GGGCGAT
GTTGTGCGGA
AGTGCCTAAA
GCTTTCTAAT
TTTAGCTCTC
TCTGGCAATA
GCTTTAGGGG
AGCGGCATAC
CTCGCTCCAA
TTAGCGATCA
CCTTIAGTGA
GAAAGCATGA
AAACCCTATT
GCTAGCGTTG
TTAATCGCCG
CCGCAAAACG
ATAGAAGCTA
ATGCTITTAG
GGATTITAG
TTGGCCTTA
ATI'AAAATCG
AACCCTCCT
TI'CGCTAACT
AAGAAAGAI'
TTCATGAGCG
TTTTTAGTGT
AAAGGGCTAT
CGTTGGCTT
AAAGCGTGAT
ACGCTAAGGG
TTATCTTTIT
TCAACCTCAT
GCGCAGCGGC
TGAAAAGCAT
CGGGGCCTGT
CATCGTI'TAT
AAACCATrI'C
TCGCTAATGG
CCITIGTGGG
GCATGGAGCA
TGTTAGGCGT
CGCTCAATGA
TAATCTTGAG
TAAGTTCAGT
TCATTGCCAG
CGACTATCGC
TGTAGGGATG
AAATTATCGC
ATATGTGCCT
TGGTTACGGC
CGATCAAGGG
TGCTAGCTI'G
CGGCGGGGCG
TAATATTTT
GAGCGATTCA
GTTAGCCGGG
GTCCGCTCCT
TAGCCATGCA
GGCAAGCACA
GATGCTCGCG
L'rlGTCTTTA
TCCTTGGAGC
ATTTGTGGGC
CGAGAAAACC
CGCCATGCTC
GCTTGCTTTA
CGGGTTAITC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1278 INFORMATION FOR SEQ ID NO:1225: SEQUENCE CHARACTERISTICS: LENGTH: 948 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genoraic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEy: misc_feature LOCATION 2 .948 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1225
ACGCTATCCA
GAATCAGGCT
GTTGTCATTC
AAAATGGATA
CAAAAAAAFI'
GGGCAAAAGA
GGGCATCTCT
CTCATGCTCA
GAAAGGAACC
CCATTGAACA
TCTAATGCGG
TATACGCACT
AT1'GGCTATA
TTI'TTGGGTA
AGCGCTI'TAG
ATCGTCCAGC
AAGAAGAGGG
CTAAGCAACT
TTTTATTGAT
CGATGACAAG
ACGCCCTAGC
TCCGTGGGCT
ATGATGAAGT
TTCCTAATGG
ACCCCATTAA
CGCCTGTGTA
GGTATGGGAA
TAGATCATGT
GCGGGAAGAG
AAATITI'AGA
AAGAAAATAA
TCCAAGAGCA
AFI'GATGCCA
CAAATTTTCT
CGTGGGGCT
CGAGAGGAAT
GAAAGAGATT
AGAATCCTTG
GGATTTAGAA
CATGCCCCTA
AAAGATTAAG
TGCGAGCGCT
CTTGGTGCGC
CAATGTGCAG
CGGTAATAGC
CGCAGAAAAA
ATFI'ATTGAA
TGTGGATAAA
CAAAACCAGC
AAAAATTTAA
GGCGTGGGGT
GCGGTTTAA
AA.AAACAAGC
A'ITGAAATCA
AATITGAGCT
AAAACTTATA
GGCGTTGAAT
GATGGGATTG
ATI'GAACATG
CCTAAAAGCT
GGCGGCGAAA
ITCCTAGCAT
TGGAAGAATC
GACACCTTAA
TTGTGATCAC
AACGCAACCT
TTTTAAAATT
GGGXTI'AG
GAGAAGAGCT
AAAAGGGGGC
TAAATCAAAA
GCGCTATCAA
CCGGGATCGA
TGGATTITGT
CGFI'GGTT
TCATCCAAAA
AATTGCATTA
GGGATTTGGA
TGTTTTGGGT
AAGGTCAG
CATCATTGAT
CATCATITCT
TTTAATCGCT
GGGTF1TGTAT
TTTTATTGTG
TAATGGGGGA
ACATITAGCA
ACCCACTAAA
TTTTATCGCG
GAAGACTCGT
CAGCTCCATT
AGGGCAGTTG
TGAAGTGCGG
TCATTI'TCAA
TTTAGAAGAC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 948 Vo 6* 0* 0 INFORMATION FOR SEQ ID NO:1226: SEQUENCE CHARACTERISTICS: LENGTH: 945 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .945 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1226 GGGTTITGG TGTTTTTAGA CGTTATATTA ATGTGCATAT GTGGGATCTT TATTG1I~r ATTGAAAAAC AGCATGCT1T AAGCTI'TCTT TGCAAATGGA AACGATI'TAG AAGAAGTGGT TITI'CCAGCC GCTTGGATGT CTTATCCCTA ATGACTACCC AGAATGCACC CTATITTGCA ATTAACACGC CTGTGTATGC AATGGGGGGT ATGGGAATIT GCCCATTTGA ATAAAATCGT GGGTATAGTG GTAATACAGG TTAGATCAAC CCATAAACCC GTTTTTAATA AAGAAAGGAG ATGCAAAAAC AGGAccAGCG.
CAGGCGTTTG
CTTATTCCGC
AGGCGTTTCA
AATCACTAAG
TGAGTITTA
GGGGGTGAAT
GGCTGGGAT1'
GCTAGAATCC
TGTG'ITGCAC
GAGCGCGAGC
GATTAAGGTT
CGTAAAAACG
AATGAGCACA
CATGAGTTC
CATCAGATGG
ACTATCATCG
ATGTGATGG
CAAATCAGTI'
TI'ACTGGTTr
GAATTTGAGA
GACGATGC
AGGCCTGAAG
ACCGGGCTTC
TATCGGCGCG
AACCATACCG
GGGGTAGTGG
TTCCACCCTT
GGCGAATTTG
GGACCGCATT
TTACGGACTC TAAAGGGAGT TGTATGCGCT GTTGAGCGTT TAAATAAAGA AATTAAAA6AC AAAAAAGAGA GACGAATGAA AACITI'CAGGv
AAGAAAAAGA
AAAAAAGC1TT T1'CAGCCGC
GGCTTGATT
GGTTAGCGAG
'FTGGTTAA
TCAPLAAAAGG
TGCAT1'ATGA
GGAGCGCATC
AGAGGGCAAT
TATCATGCGC
TTTTAATAAA
AAGCACCGCT
CAAGGGGTGG
AACCTACTAC
GCAGTIGATT
AGTGCGCTTC
'TTTGAAGAA
AAATCGGCTA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 945 ACCAAATGGA ACATGAAAGA CAA.TCIrGA TAACAATAAT CTCAAGGCAC CAAAA INFORMATION FOR SEQ ID NO:1227: SEQUENCE CHARACTERISTICS: LENGTH: 1380 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION I1.. .1380 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1227 ,of*, *0 S
GATATTGAAT
AATTTGCCCC
AGCTCACTGG
GTCATCAACT
ATCCTATGA
TI'ACCTGAAG
AGATTCGCTC
ACTITTATCC
AATCAAGCGT
GGCATTGAAC
GATTTGGGCT
TTAAAAGATG
CTCAAAAAAT
AAAGAATI'GG
TACGATAAAG
CTGAATGAAG
GAGATTTTCA
GAGGCTI'TAA
GTGTTGTTGC
CT'FITTAAAA
TTTATGACTT
AACGCTAGCA
AACGCGAGCG
TCGCCAATCT
ACACCAAAGA
CCAGAAAAAA
ACCGCTI'GCA
TTCATTGCAA
ACATTGTGAT
AATGCCCCAG
AATCCAGCTG
TIGATCAAAA
ATGCGATTT
ATCTTCATT
GTGCTAAGAT
ACGGGGCTGA
AATGGAATGA
CGAACGCCAT
CGCAAAAAT
ATAAGGCTGA
ACGCTI'TGAA
AAATCTI'AGA
GAGAGAATT
TAGGGCTTAC
AAGAAGAGAT
TTAAAAAAGA
TTATCATATT
AGAGATTTTA
AATCCTCCCT
AAATTGGGGG
ACATTGCGGA
TGATGGGGAA
ATGCCATAAA
GTA TTCTTG
TTACTTGAAG
GCACTI'GTI'A
AGATGAGCCT
GAGCAAATCT
TGCCGTAAGG
CAACGCTITA
TACCCCTACC
AGCCCGCAAA
AAGCGC?1'AC
CGCGCAAAGT
GCCTATGATC
CAAGCCTATA
CATTAATGGC
TATTATTrTG
AATII'ATGTG
CCTATTAAAG
AAAAATAGCG
TATITGACA
GTGAGCCGTC
ATCGTGCCTG
GGCAATCCAT
GACGCTI'AG
CGTTATACCA
TATTI'CATGC
TACGCGCGCT
TI'CAAACAGC
AAAGGCAATG
CTCTI'TATCC
GAAGGCGCGC
ACTCTAAGC
AAAGTCTATG
GCG TTAACA
GATGAGCAAA
CCGCACACGG
GAAGTAGATG
AAAAGGCGCG
GCTAAAAAAG
CCTAATAAAC
TGATCACGCA
GGGAGTGGAG
AAGAAAATCT
AAAGGTATTG
AAACCCAACT
TAAAAAAGCA
TAGAAACAGA
CCCCCAAAAA
CGGTGGACAC
FI17CACTAA
TTATCACTCA
TCGTTAGCCC
TFF1'TGCTGC
ACCGGTTTAT
CTGAATTTAA
AGGCGTITGAA
CTTIGATCGC
TITTATGCGA
CATGGGAATI'
AAAGCGCTTI'
CGGAATTGAA
AATTAGAGAA
TTGTTAATT
AAGCCCTCAA
CGATCTI'CT
CGGTAAAAGG
GGGAGCGCCC
GCCGGTAACT
TGCGAGTI'GG
CACCATGGAC
TCAGCGTGAA
TTATATTGGC
GGCTTTAAGG
AGGCATGGTC
TAXAGAGATA
CCCGCCGGCT
CAAGCGCTTA
AGAAGTTGGC
AAAATCGCAT
AAGCTGCATG
GGGTTATT
GAGCGAGAGG
GATAGAAGAC
AGTCAATATT
ATATTI'AGAA
TGTTACCGCA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 D* INFORMATION FOR SEQ ID NO:1228: SEQUENCE CHARACTERISTICS: LENGTH: 1209 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature 879 LOCATION .1209 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1228
CTAAATTTGT
TTAAAGGCGT
ATTCAAATTT
GTGGTAGGGA
CAAGGGTITA
TATITGAATG
TCGCACGCTT
CTCGCTAAAG
ACGAACGCT'
TTTT'TAGGGG
AATATCATCG
AAACACGCGC
GAACGCCACC
GAAACGCTAT
ATCGGCCGTT
AGCGCTAAAG
TATAATIGCT
AAAAAGGTTT
GGGATTTTAG
AATTATTTGG
AAGAGGGAT
GGCTCAAATC
TTTTAGAAAC
ATAAGGATTT
CTAATGGTAA.
AAGTGT1'GCA
GCTCTGITGT
TCAGTAACGC
ATTGCGATTA
TGGAAAAAAC
ATAGTTI'AGA
CTCCCCAACA
AA'rrGATTGT
ATTTAGCCCA
TGCCATGCAA
GCGAGCTTTT
CCTTAAAAGA
ATCAAGATAA
TGATTTTAGA
AAAC LTTAGG
TGTATGGCTC
GCTTATGAGG
AAAGCCTAAG
TAAAACGCT
GGGCAGCACA
TTTCACCTCC
TAAAGAAAGC
TTGCTCGTAT
TI'GGTTITA
CCTAAGCGTT
AAGCATTGCG
AGAACTGGTT
GGTTCAAAAT
TTTI'TAGCG
TAAACAAGAA
AAGCCCTAAC
AGAAATCAAA
AGACGCTTTT
ATTGCATAAT
GTI'AGAACAC
ATTTCTGGTA
GGAAATTICAA
GAATACCATA
TTTTTTGAGA
GGGCGGTTTT
CCTCATGTTI
GTTTTAGAAA
TTI'GAATACG
GAAGCAGGGC
TICACCCCCA
ACTACTAAAT
TrAAATGTGG
GAAAT.TTCAA
ATGAATITAG
GTTTTAAAAA
XTITAATAG
CGCATCTI'A
TGGTGCTAG
GAAAGAATTA
GCCTTGFI'TG
GCCAACGCTT
TAATGAAAAA
AG'ITCGACCC
TTCAAGCCAA
TAACCCTT
T IGAATTCAG
ACGCCCACCA
CTACCTTAT'
TTGGGGGGGA
TTGATI'ACGA
TAAAAGCGAT
CTCAAAAAAT
AAGGAGTGAG
AAGTGGCTCT
ACCTAAAGCC
ATGTGGGGCA
ACGCTCCAAT
AAATTTTAAA
TCCAATTAGA
AAGAACTGAA
TFI'ATGAACG
TAGTCATGGG
TAGCCGTTTC
AGTCATTCAT
ATITAGCCGAT
GGAGCGCTT
GCAATTGCAA
AGCTGTCATG
GF1'TGACAGC
TCATAAGGAA
GGGCTCTCTT
CGCTAAAGAC
CGATATAT'
AAAGGCGT'1
CCTAGATTA
TAACCCCCAT
CGTI'TTGATT
GTCTGTGGTT
AAAACTTAAA
AGAAAATGAA
CTATCCAAAG
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1209 INFORMATION FOR SEQ ID NO:1229: SEQUENCE CHARACTERISTICS: LENGTH: 681 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .681 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1229 0
AGCGTGTCCA
ATGAACCCCA
CCTTTATACC
ACGATTTTCA
GGCGTGTATG
AAAAGGGCGA
CATGCGTGCG
GATTTACCCC
GCGTGT1'TA.G
AATGTGGCGA
CATGACTTTA
GTCATAGCGG
TGCAATI!AGA
ATCAAAGTT
ATTGCTTAGG
ACAAATCCT
TGGTGGTTAA
AATTGAAAAA
CCTATGXT
ATATTTTAGA
GTTTGTTGTA.
GAGCATTTAA
GAGCGCGGAT
AAATTGCTI'C
TAAAAAATCC
GCCTTTAATC
GTGTAAGACC
TGGAGGGGGG
TAACGAAATT
GAAAGAATI'A
AAATAAAGGC
6
TTGAGCCAT
AAACCAAAGC
TTGTTGGAA6A
AAACAATCGC
GCCCCTITAA
AACCCCFI'AA
ATGGCGCTAG
ACAGATGAAA
TTAGAGTATG
CAGATI'GAAA
AAAGATTCGC
AGGGCTAAAG
GCATTATGTG
ATTI'GGGCGT
ATTTTGGGI'
GAAAAGAGCT
GGCCAAAAAT
CGTTGAAGGC
TCGTGTI'GCA
AI'TGAGCGC
ACGCCAAAGA
ATACAATGGT
GATI'AAAAG
GAATATTGAA
TTTATTCGCG
TTTCACTAAA
CCAGCTTTTA
ITTAGGCGTr
TGACATTACG
TAAAGATTT
AAGCGTI'CAA
GGTTGCGGCG
AGGGCGTGAG
120 180 240 300 360 420 480 540 600 660 681 CATTTACAAA AAATCATAAG GCTAAGCCAT GCCTAGCGTG T INFORMATION FOR SEQ ID NO:1230: SEQUENCE CHARACTERISTICS: LENGTH: 882 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (iMOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .882 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1230
AATI'GGTAG
GGTTTGAGTT
AAATTGGTITG
GTGTI'TTATG
AATAAAGTCC
GCTTCAGCGT
CTAATTTATG
GCGTTTGTGG
GCGGTGATGG
AAGCGTTACA
GCGATTGTGC
TATAAGCGCA
AACGCCTTAA
GAAGACGCTC
G TI'IAGATT
TGAGTGTI'CC
TGAATITACG
GGGAGGGTGA
AGATTTAAA
CTATTACAAG
TTGCGTTT
AAAACCACCC
AAAAAAAGAA
TGATCCCTAA
GCGTGCAAGA
AAGGGAAGTG
TGCAAACTTA
TGAGCACGCT
CTAAATI'AAA
TIGACAATGA
AAAGCATGGG
GGGCATGGGG
AGGGTITGCT
GGATAATATC
AGTGATAAGT
TAGGGTCATI'
AAGCGTGTT
GGACTTGTTG
TCCCGTGTI'G
?I'CAGGGAGT
GCAGGTTTTG
TGGAGTCCTIT
AATGACGGCT
TCTAGCTCAG
TFI'GATAGAG
ACCCCGGCGG
TTAAAAACCA
TCTACCAAGC
AACCTITCGC
CGTGTTGTT
TFI'GCGATCC
GGI'CGTCGT
AGCAAGAAAT
ATTGAGAAAG
TGCAACGAGT GCGAATI'AG CAATCGT'FTT TTTATI'GAGC AGGGATCCCT AAATT'TAA
GCCCCGGTTT
CTAGTAATAT
CCAACAATAT
CGT TTAAATT CGATGA ITGT
AAAACATTCT
TGTTTGGGGG
AAATCCCTTC
AATCGCGCCA
ATGCGAGTTT
CTAAAGACAG
AAAAGCTCGC
TIAACAT
TCCCTAA.ATT
AC
TGATTGCTTG
CCATGCGGTG
'I=CACCAAA
'TTIATTGCAT
GGGGGCGGTC
CAATACTGCT
GTATAATGCA
TCTCTTIGCCC
GATGACGATG
GATGCACCAA
TTAGAAAAT
GTGTI'ATGAA
TAGGGTAC
120 180 240 300 360 420 480 540 600 660 720 780 840 882 INFORMATION FOR SEQ ID NO:1231: SEQUENCE CHARACTERISTICS: LENGTH: 894 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .894 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1231 TTAGTA2'TCA AAAAGCCCTT TTTTAAAAAT AGGTI'ACTAA ACGT1'ACTAA TAAGITAAAA T1CGTGAAAA TAACCATAAT GAFI'AAAGAT TITAACCACT ATI'GTAGAAA AATAACGAGA GGGTTGTAA AAATTCCCAC CAAAAAACAA GGAGCAAAAA AGATGAAAAA AGCGGGTTI' 881
CTTITTI'TGG
TTGcGTAAGA
CCATGCATAG
TTGCAATAT'
GATCCTTCTA
AAATACGGAA
CGATCGCAAA
cTGGATAATA
GGGCATAAAT
GTCATGCTTG
GTGGTGCAAC
TTAAATCGCG
CGGCGATGGC
TTIGTITTGA
AAGTCAAACC
TGTTGATGCC
CGCCTAACT
AACCCATTCC
AccATTICA
ATCTAAAAAA
ATTITGGCGCG
CTAAAGAAGT
AGAGCGATAA
cTTcAGCCGA
TATCATTGTT
GA.AATG~TTTG
CGACGCCGGC
AACGACTCAC
TTITTTACTTG
TGATIATGCG
CATCCATATI'
TATCAACAGC
TCGGGTAACA
GCCTAACGCG
CTCCT1iTITC
AGAGATTCAA
GTGAGTTTAA
CCTAXI'TATG
TATGTGGTT1'
ATIAGTGGCA
TCATGGCAAG
ATCTCTTTGA
TCTTGCATTA
CGTI'GGTCGC
GAGAGCGAAT
CACAAACGCA
TTG'rrAGCGA
GATCATGAAT
ACCCCAAAGA
AGAAAAATCA
TAJAAAGATAT
TTGAAAACCC
CGCGCGATT
CGATCAATITC
GCCTI'GATGT
CATTATCAGG
TAGCGCAAAA
TGGGAGACTA
CACAATTTAA
GCGCGATT
TCCGAUKivI'
AAATCC'ITCA
TAACGGTCCG
TTTGTTGCTT
TATGAGTAALA
TAAAAAAGGG
GCGCAAACAG
TGGCTTGAAC
AAGCCCGT
TGGCTTGGCG
CCCATTGACT
GCGT
300 360 420 480 540 600 660 720 780 840 894 INFORMATION FOR SEQ ID NO:1232: SEQUENCE CHARACTERISTICS: LENGTH: 363 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAMEIKEY: misc-fieature LOCATION .363 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1232
TATCATCGCA
AAACGCAACG
TATGAATGGA
AATCT"ITI'AC
TCTTI'GGTGC
AATGTGGATI'
GCT
CTAATACCAC
ACGCCTACAC
ATGGAAATGA
AAAATGGGGA
TTAAAAAAGG
GTAAAGTGGA
GATAAGGATA
CTACCATGAT
AATTAGTAAT
CTCGGTCAI'
CACTAAAATC
AGGGCAGAGC
ATI'ATCATGC
GGCACGCAGT
GAAGAATI'GA
CTCATITAAAG
AAAAATATCA
TTGTCTFIAA
AAGATTTACC
TCGTTIGCTC
.TCGTTAAAGA
ATTTAAAGGT
AGCTTGTCAA
AATCTGAATI'
CCCATGCCCT
TAGCTGTTI'G
TTGCCATAAT
TAAAGGCTCA
TAGCGATCAC
CCTTAAAAAA
INFORMATION FOR SEQ ID NO:1233: SEQUENCE CHARACTERISTICS: LENGTH: 225 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1. 225 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1233 AAGGGTTGTT TTATGCGAGA ATTITTTTAAG AAACTrGGCA TT TTT GGTTT ATTGGCTTAG ATGGATGTI'G AGTGCGTTGG GTrTITTATT AFITCAATI'T TCCGTTGTGG CTCAATCTTI GCGGTGATTT 7TTTCAAGTT GGATAAGITG ATTITI'TCTA CAGAATACGC TTCCAAGCTG TGATGCTGCC T TFI'ATGGAG TCTI'AGGGCA AACCATTGGA INFORMATION FOR SEQ ID NO:1234: SEQUENCE CHARACTERISTICS: LENGTH: 1491 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1491 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1234 9
TCTTTAAAC
~TTIGCCTT
CATGTGGGCG
TTCATTCAAG
GGGAATTA
GTGGTCACTC
ACAGGGTTTA
GTGTTGAGCG
TACTI'GCTCA
'ITTGTGATGA
AATITTGGCA
ATGCTCTTFI'
CCTATGCACA
CATGCAGCGA
AGTGCGGTGT
GGAGCGAGCA
TCTCAATI'AG
CACCTCTrTA
CATGCGATGG
ATCACAGCTG
GGCTATI'TCT
TGGTTTGT1'C
CTGGTGTTTT.L
CATGCTITG
GCCGTTT
GCTATGAAAG
TAATCGGTGC
TTTCAATTC
CATGGCATCA
AAGTCGGCTI'
TAGTTCT
ACCGCTAIT
ATAATTTI'T
TTGGCTTG
ATCGAATCAC
CCCTCCAGTA
ACATTAGCGT
CATGGTTAGC
CGATGGTAAC
TI'GAAGTIGGG
TGGCTITAGT
GCTATATGTI'
CGCATGCGTT
AAGACAATCT
TCTTTATGAT
CCAAAGACAA
TITI'GATI'GG
TTGCACCCAA
AGCATGCTAC
CATITTATCT
GTTAAGCATG
GGTTTATGCG
ITIGTGCGTG
TCAA.AGCTAT
TTCCCTCATG
CTI'AGTGCAT
TTCCTACCTT
AGGGC TFI'17C
GTATCATAAA
GGATIAGGC
TAAAGAAGTC
GTTTCTTT
CAACGCTATG
CGCTGGGGTG
TTA'rITTATC
CAATAAGGAT
TGTAGCGGCC
CTCAAATCC
GGATATWACT
TATAGGGTCA
GAT'TTTAGAG
GGCGATCTT
ACAACATGAA
CGTTAGGGGT
CTCAAGTGAA
CAATATTCFI'
GGGCTGTTTG
CTGGTTTCTT
GAAAAATATT
CTGGATAATA
GTGTAITCTA
AGCGGCTTTG
ATTGGCTGGG
AAAAGCGCGA
ATGCTCATGG
TTTAGCATGC
A LTGGCGCTA
GAGGGGCCTA
TATCTAATCA
GCATGCT1TAG
TAAAACGCA
GGGCTTGGGG
CTCCTFF1CT
AAAATGGGCG
GTGGCTGT
GTCGCCTFI'G
ACCGCTITr
ATCAACCACC
TTTGGCGGTC
TTCCTAGTGT
CTITGCTGTC
GGGCTAAAC
TCATTGGCGC
TGTI'TGACTG
TCAATGCGGT
TAGGCTATAT
TG7rI'.CCAT
AAGGGGTGGG
ATAACGCTI'C
GGATI'ATTT
TCAATAACGC
TGGGGAAGAG
CCCCTGTATC
TCAGAGCCAA
GAGCGTFI'GT
TCGTGGCTTA
CTTATGCGAT
TAGGCTCAGG
CTI'TATACAA
GTGGGATCTA
GGATGCACCA
ATAGCI'CAG
CCCATGAAGG
ATI'GCCGGTT
TGGAGAGTAT
AGTGGTGTTG
TAAAGCGTTG
GGTGGTTCTI'
GATCGTGGTA
CATGATTGTC
GGAGCATGAT
GCTGGTGTI'G
GCTATGCTCT
TATTGAAGCC
GATCTTGG
CGATTATTCC
TGCTCAATI'C
CGCTCTCATC
TCCTTTGTAT
GGCTCTTT
TTICCACGCTI'
CGCGCTrTC
CAATGTCATG
GCCTATGAGG
CCCCTTI'GCG
CCACATTFI'A
ACTCATCATG
CCAAAAATTT
ITTCAGAAGA
C
120 180 240 300 360 420 480 54 0 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1491 0 00 0 INF ORMATION FOR SEQ ID NO:1235: Wi SEQUENCE CHARACTERISTICS: LENGTH: 828 base pairs TYPE: nucleic acid STR1ANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .828 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1235
AACAAGCCGA
AAAACAAAGA
AGACAGAGGT
GAAGCGGGCA
AACACCTI'GC
AAAATGTTGC
GCGAACGCTT
AAAATCGTAG
GGGAAAGACG
ACGATCACTA
TATGACTTGA
ACCCACAAAC
TATTTCACTA
AATAGCGCTA
ACAAGGGTGC
AGAGAATAAA
TAAAGAGAAA
TCjAATAGA
TAGTGGTTGG
GTTTATI'AGC
TAGGCATCGC
GCATITCGCGC
CTGTCAGTAA
ATGTTGAAGG
GCGATATCAT
AGTATTGGAG
ACAGAAGCGG
AATTGAAGTC
AACTTATGAA
CGAGGAAATT
CCAAAAAAGC
TTCTATI'GC
TCAAGGGGAT
AGTGGATTTT
GCGTGTGTTG
GCAAGGCTTT
AAAACAAAGA
CTGCCCCAAA
CCTACCAAAA
AAAATTCTCG
TATAGCCACA
GCTATTAAAC
GAATTGAGCG
TTCACTATCA
ATTCTGCCCA
CCCTTAAAAC
GGCTTI'GTGG
AAAGCCTTAG
GGCTATTTAT
GCGAGCCTAT
AGAGGCAGTT
AGAAAATCAA
CCACTTACTT
CTCTTTTGCA
AACAAGCCCA
TCATTCTI'AT
AAGAAGTTI
ATAGCGACGA
GTCTCAACCA
CGGCTI'TAAG
AAGAAAACCT
AGTTTGATCA
TAGGAACAAG
CAAGCCTT
GCTTCAAAAG
ACAGAAAACA
G'ITGCTTGA6A
AAAATCAAAT
TAACATCGCT
CCCCCCAAGC
TGAACATGAA
TAGGGT1'TI'T
ACTAGAAGGC
GITGAAGGC
CACAGAATGC
TCTAACCAAC
CCATTGAA
120 180 240 300 360 420 480 540 600 660 720 780 828 a a a 9 a. a a a TCCCTACAGA AGCGGGCTT AGGACAGGOC TAATCACAGA AAGAATCGAA GCCACAGAAT INFORMATION FOR SEQ ID NO:1236: SEQUENCE CHARACTERISTICS: LENGTH: 669 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .669 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1236 .00 0. a
GGAGGTTI'A
GCGACCGAGC
TTAGGGCTTA
CAAC'TCCCCT
GGCTCTGAAA
AGGATCATCA
TTGGGGCGTI'
ATGGGGAATC
TGGCCAAACA
AGTI'AAAGA
CGATCAAGGA
TAAGCCCACG
GGTGTATAGG
CGCATAAGGG
GCATITATTG
GGTTTGAAAA
AGAATACAAG
CACCATIAAA
ATTrTITAGC
CTATCGCGCG
CTGTGGGCTG
CGAAGACAAC
CGGGTrGTGT
CGCCAGCACC
CAACTTCCTA
ACGAGCTTGG
CCAAGCGTAA
GTGCATCAT
TGCGAAAAGA
CGCAAAAAGA
GCGGAAGTTT
CAACGCTCCC
AACGAGCCGA AGTCCATAGC
GTTTGGATCT
CCATCCATTA
TGCAACGGCT
TTTGCACGAG
TCGAT1'CTTA GCCCAGAATr A7ATACGGCTC
ATTCAAAGGG
CCCTATGGAG
TTTAGACTCA
CAACTGCATA
CACGATCAAT
GGCGATCGTT
TAkAGCGAG 120 180 240 300 360 420 480 'rITCTAACGA GCGAACAAGA CGCTAAAAAC TGCTCGCATG CCGAATTTTT AGGCTrGGT GCGGTAAGCC CTAATFIATAA CGAACGCATG CAAGCCACCC CITI'AGATTA TGTCCAAGAA C-CTTCAAAAG AAGAATCCAA AGAAGAGTCT CCAACAAGCC CAGAAAGCCA TAAGGGAGAT
GAAAATGTT
INFORMATION FOR SEQ ID NO:1237: SEQUENCE CHARACTERISTICS: LENGTH: 624 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 624 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1237 a a
ATATGTCCA
GCCATAAGGG
TTIAAGCATGG
GCTAGTAGCA
GTGGTGCAAA
TTTCAACT
CTTTCATITG
AACCTI'TCTA
ATI'GGTTATG
TTAGTCGCTA
ACGC.AATT'A
AGAACCT'CA
AGATGAAAAT
CGTTAGTGGT
TGGTTTI'TAT
TCACGGTGTA
CCGCTGCAGA
GCGTGGCGCT
AGCAAGTCAA
TGCTTI7.TCAC
TGGTTGGAGG
TAAAGGAATC
AAAGAAGAAT
GTTTGAAACC
GATCACAACC
TTCTGCTTTT
TGTGGGTGCG
AGTAGTI'GAA
GTTGCTCACC
TI'CCAACGCT
CAATTACCTC
CATCGCTACA
TCTA
CCAAAGAAGA
ATITGCCTTT
ACAAATATCC
TTCTTTTTAC
GTCATTGTGA
CGCAAGCAAA
TTGAITTTAA
ATTGATGCGC
ATI'CCCTTTG
GGGATTCAA
GTCTCCAACA
ATTTCITrGC
TCTATGCCAT
TGGACGCTGA
TGTATGCGT
GCCCTAAAAT
GCGCTCCTAG
AAATCCCTAA
AAGCGGCGGC
AAATCCATGG
AGCCCAGAAA
GATCCTTACT
TACCGCTCTC
GTTrTTTGGGC
TGGCATGATG
C LTGTGCGT'
CATTGGCGAA
CATTAAAGCG
TTTAATGCTT
GAAAAATCAC
120 180 240 300 360 420 480 540 600 624 .10 0 INFORMATION FOR SEQ ID NO:1238: SEQUENCE CHARACTERISTICS: LENGTH: 738 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .738 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1238
ATGAAACAAT
ATCTI'AAAGC
TATGCGGATG
GTGCATCGTC
TTTACAGGAA
CACTCTCAA
TTAAGCGGTC
TTAGGCAGTA
TATCCTAATG
GTAGAAGTGG
AACTTGAACG
GTGAATGTAG
TTAAAAAGAA
GTCCTTTATG
GAACAGACAT
CATGGTATGC
ACCAACTCAT
ACAACCAAGA
TGTATAACTA
ACGCTACTTTI
GGCATACTGA
GCAATCGTGT
CTAATAAGGT
GCAATGCTAA
ACCAAAAAAG
GCTTATGCCT
TTTGGGGCTT
TATATGGAGT
CACAAAAACT
CATCACAGCC
CACCGGAGGG
TAATCTAGGT
TGTTACTTT
GGGATCGGGA
TACTATCAAT
CAGCGTTIATT
ATAAAACGAT
TTACTGATTG
AGTTGGGGGG
TGCGATAAAT
TGGGCAGGGG
AATTTAAAAA
GAATATAATG
GCGAGTAGTG
AGCGCTGGGA
GCTGGCACGC
TCCAATATCA
ACCATTAATT
CGCATCAAAA
GCGGGTITGC
AAAAAAGCCA
GGGAGGAAAA
GTAATGCGGC
ATGATAACGG
GGGGGAATI'
GGAATAGCTT
CTATCAATGT
ACACCGGCAC
GCGCGTATAA
CGGTT'CT?1'
TCAAAAAACA
TAGTGGGGTG
AAAGGTATGC
AACACAACAA
TAACTACTAC
CACTIATITT
AGACATI'GAA
CACI'CTTGG
GAATAACAGC
AGCCACTTTA
AACI'CGCAA
AAATGGGGAA
120 180 240 300 360 420 480 540 600 660 720 738 TACTTGCAGT TCTTTAGC INFORMATION FOR SEQ ID NO:1239: SEQUENCE CHARACTERISTICS: LENGTH: 1200 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: -Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .1200 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1239 .9 9 9 9 9* 9 9*
GTTTTCACGC
GAAATCTTAA
TGTTTGTI'CA
TAT1'GCAAA
ACAGGAAGCT
TI'CAACGCGC
AACCAGAATT
GGCGATATI'A
GGCGAACAGC
TTATTGGATT
TATGCCCCTA
ACTTI'AAAAG
AAGGTTAG
TAGGCTTAG
CGTTTGCAAC
TTAAAGGGCA
GTAACACCGG
GACGGGGI'T
AAATrGAAAA
CAAGCCACCA
CAAGGGTGAA
ACACAGAAT
TACTCGTITI'
CCGCTAAAGA
TlTGGGAAAAC
ATGCAAGCCC
TAGACCACAG
AAGAAATCAC
GCGCTTTI7'C
AGCCCCTTTA
GAGCGCTTCT
TAAAATCGCC
CAGCACCAAA
TAAAAGTGTC
GAGTGAAAT'
CCGTCTCATT
ATCTI'CTTAT TCCTCTTI' ATFI!AGAATA TTTTAAAACT CCAAACGCTI' AGAAAAAGCC
AATGGGATTT
TTAATCTITG
TCTTI'AAAAA
AATTTCTTGC
AACACCCTTI'
TATATCGCTG
GAACCGCACC
TTAGAAAATA
TITrGCTACT
TATTCTAGCC
ATCA.ATGGCG
ATCGCTTCAG,
CTGTTTTG
ATCAT1'ATAG,
GCGAGCTTGC
GAAAGTAATG
CGCTCGCGCT
AAAAAGTCTTI
ATITAAAAGT
ATCAAATCT'
TAGGCATTGC
AAGCTGGGGC
TTGCCGTGGT
TITGCGAGAC
CTGTGGAAAA
TAGTTAGAAA
'TTTGGGAAAG
CGATITTAAT
AGCTTAAGCC
ACGATAGCTI'
ATCAAGGGCG
AGGCTTTAGC
AATCTIGCAT
GGGCTATITG
ATCCAAGCAG
CATCGCCAT
ACAAACCCAA
GAACGATATT
AAGGAATAAG
CGCAGAAGTG
TAAAGCGGAA
AATCAAACCC
CGTCCAATCC
CTTrGAAACG
CGCTAAGCAT
TATTAACCAT
TAATGGGAAT
TAAGGTCATT
GCAAAAAATA
GA'FTGCTTCC
AAATATCTTA
TAFJTACATI'
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 9* 9 9 9
AAGATAGCCC
GCACTTCTT
GGGAGTTTAA
AGACAGAAAG
TGITGGAAGC
TGTTAGAGGG
GATI'AGTGGA
'FTGATGTCGC
CCCCCCAAAA
CGATITCAAGG
TTTAATAGAC
TGAAACGCT
CGCCTATAAT
GATCAAACGG
GAATCAAAAA
CATTCGTTTA
AAGCAATACA
TATCATCACA
AATCTTACTC
CGATTTGATT
GGGGAGTrGA ATI'CCAAAAC AAGGATAAGG CGCAATI'GGA TTATI'CGCTA CTGACGCCCC INFORMATION 'FOR.SEQ ID NO:124O: SEQUENCE CHARACTERISTICS: LENGTH: 2151 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (gerlomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAMEIKEY: misc..feature LOCATION 1 .2151 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1240 p p p p
TATGCCTTAA
TATCATGGGG
TTAATGCCCT
GGCTATGCGA
GGC71I'TTGTA
AAATII'GGTI
GTTGCACCCC
CCTAATAGCT
AGACAAAAAT
TGCTATTTCA
AGGCATGTTA
AAAGCTAAAG
TCTTTTTATG
AGCCCTTAT
CCACAAACTA
CAAGTGGCTG
CCTGAACCCC
AGTTGGGCAA
ATGTATGTCT
GAAGAATTAA
ACACTTTCTT
GAAAGCTCTA
AAGTTGCCTT
TTCATCACGC
TTAAAAGGCG
ATI'GTCTCTA
GGTCAATI'GG
GCCCAAGATA
GCTACCCCCT
GCTAATITGC
ACTACAGAGA
GGGGAAAAAG
CCACAAGAGC
ACCTTAGAAA
TI'AAAAAAGC
CAACAAAGCG
AGTCGITGAG
CAAGCATCTI'
TTGTGGCTAC
GATGGGCTAA
AAGTGGTGCA
TTCCAAAGCT
CTGGTGCTGG
GTAITATCAC
TCTI'AAACAA
ATCCTTITGA
AAGCAGTAGG
AGCT1'TTTGT
ATGTCTCTAT
ACAAGCAACT
ACGCCCCTAT
ACCAAAAATA
CTATGGAAC
ACACTCCTGA
ATAAAGACCC
GAACGGGCAA
CTI'TAGTAAU
AACCTGAAGA
TCTTGTTAGA
AAGATI'ATGC
TGGTGCATTA
AGGAAGTGGG
TCTTTGGAGG
T1'ATGAATAT
TAAAACTCAA
CTATTGATT
TTGAAACAAC
TAGAGAATGA
TGAAAATTC
ATGCTAATGA
CACTGAGTGA
ATGAAGAAAG
ACAGGCTTAT
TGAITTAAAA
GATITTATATC
TGTI'AAAGAT
TAGATTAGG
TAGAAATGTG
AAAAACTGCA
TGATATTAAA
TAGAATTA
TAAAAGGATT
CGATGGTATT
CTITTTTGCT
CGCACCAGCT
TTACCAA6CAC
GAAAAATCCC
CATAGATATO
AAAAGGGGCG
TGATGAATT
AAAAGTGCGT
TATCAGTATT
AGCCTTrI'TA.
GCGTATTTTT
AATGCCAGCA
TATGATTAGA
TAACATI'GTC
CGAATTTACA
TAGCTCFI'CT
CAATTCAGAT
AGCTAATTAT
AGAAGTAGAG
CCCTAATCAA
GAGCAATGAG
AAACTTAAAA
AAATATAGAG
*AATCAGTATG
*CGAACAAGAA
TTCTTTTCTC
TTTGAA.GTCT
AATCCCAA
ATAGAATGCT
GTGCAATITG
TGCTATGACA
TGTGTCGCTT
GGCGAACTAA
AT'FFFTAATC
GT1'GAAAAGA
TTTGTAGATG
CTTFI'ACAAG
AATGATTATG
GATAAAAAGA
CAAGCTAATG,
AATGATGAAA
TTAGATGAGA
GGGAGCATTA
GAAGCTACTI'
TACATTGTAA
GAGAGTATTG
ATCAT1'GCTG
CTTTGTCGCT
AAATACTATA
AAAGCGTGTT
ATCTTACTAT
AAACCACAGA
TTAAAATTTT
ATAATGGCTT
AGCCCITAGG
TGCCAAATTT
GAGATAAGAC
CTTATGGTGA
TGACCTT1'GC
AAGAAGACCA
TAGTAACCAA
CCCCCTTAAT
CAGGCGAAGT
TTTTAAAACT
AAAACTATGA
TTATAAGGAC
TGTCTTCTIT
CTAAAATGAG
TCGCTCAAAT
CTAAAAACCT
ATGAATTTGT
CTTATAATGT
GCGATGATGA
1'GTAGGGCTT 3CTAATCTCT A6ACTTCGCAT
TAGCAAAGAG
TATTCTAGGT
AACGATGATT
ATrTGACTTTG
CGCAGGTTAT
TGATAACACT
GGAGCAATTA
lTr.GGTATCT
AGGGCATAGC
ACACCCTAAA
TATCTTAGAC
CTITT'AA6AT
CCCAAGAGAA
AGATGCTAGG
TAAGCGIT
CTTTGATTAT
TGATATAGGC
TATGGTCAAA
TAGATTTGGT
TGTCCCCTI'A
TrI'GAAAATC
AGATGCTGAG
TACCGAAAAA
CTTACTCACA
AGGGGCTAAA
TI'IAAAAAGA
TATACAACCC
AAGTAATAAG
TCCCACTACA
AAGTCCCATT
TGATGAGATT
TAAGAAAATG
T
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1800 1860 1920 1980 2040 2100 2151 p.
p p p TTTAAGATGA ATAGTGCTGA AGACGATCTA AAAATrATl'C
TATAGCCATG
GAAGTCATTG
TGGTTCAAAG
AGACAAAGAG
AACAAAGCTG
AGAAACACTA
GAAAGCGAGA
CAAGGAAATC
GAAGAGAAAA
GTTACACAAA
AGGGTAGAAA
?I'ATTGTTAC
ATAAAGAGCT
TI'GAAGAGCC
ACTTAGAACC
ACGAGAATAA
AAGACAATGA
ACAATGAAAT
GAGCC'ITGTT
GCACCCAAAG
INORMATION FOR SEQ ID NO:1241: i)SEQUENCE CHARACTERISTICS: LENGTH: 7320 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) 887 (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .7320 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1241 9**e 9@ 9 9* .9 9 .9 *99* 9* 9 9 9
TATAATCATC
CAAAATGGAA
CCGCAAGAAA
AGTGATGAAG
GGAACAAGAG
GAGCGAGATA
GCAAGAGCGA
AGCGAAGAAA
CCATCTCATC
GGACAGACTG
GACCATGAAA
AACCAAAATG
AGTGAGCGAT
AGCCGATTAC
AGGGATCAAG
ATAGAAACA
CAAAACAACG
ACTAAAATCT
TTAGAAAATC
GTGCTGGATA
ACACAAGAGA
GCGCAAGAGC
ACACAAGAAC
ACGCAAGAAA
CTTAATCCTA
CGCTACAAGG
ATCTTAAAAG
GGATGGGGCG
TTAAACGCCT
TACTACACCC
AATAACGACA
GCTCATGCGC
GCTAATCT
TACCAA'ITCT
ATCTATAGCT
AAAGCTATCA
ATGGATGCTA
GCGATAAGAC
GTGCTrTTAT
TATTATGACP
CGCITTGATI
CAAATTTAAG
AAGAGAGAAC
TICACCGCAG
ATCTI'TCACA
GAGT ITATCG
GAATACATGA
ATAGCAATGG
AGGGGGATAA
AACAAAATAG
GACGCTTACG
ACCAAAGAA
GAGACAAAAG
ATGGAATI'GC
ATCATGCACG
AGGGAAGACT
ACACTATAGC
ATCCTTTAAA
T TTATGACAA
GCCTTAAAAA
GTCAAGCCAT
GCAAAATAAC
AAACCACACA
AAACCACACA.
ACGCGCCAAC
AAATAGATIT
CTAACATTAA
GCGATTACTA
GGTI'AGAGAG
TACTCACTAA
CTAAAITAG'I
ACCATCCAAA
CAAGCGATAP
CTAAATICCl ATcAAGAAT;
CCAATGACA;
AAGAATTGAl
*AAAACCCTA;
TGCCTAATAC
AAAAAGGCG'
AGATACTCA]
LGTTT1ATI'C(
CGTTGCTGAT
AAATCGCGCA
AAGCGAACCT
CCAAGACCCT
ATCTAGCGAC
ACATGTATCT
AGCATCAAGT
TCCCAGCGAT
CTCCAGAGAT
CCTITTTTGAT
AAGGAGCGAT
CCCTAGACAG
TCAAGGAAGC
ACTCAGCGCA
TFI'ATCAAAT
GAGTGAGCCT
AGATAGCAT
ATTCCAATTA
ATCCATTGAA
TGATTTAAAC
AGACAATAGC
AGAACAAACC
AGAACAAACC
CACGATAAAA
TAAACCGAGC
*AGCCATTIGAG
CGCCACT TT
CTACT=AAP
*AGATGAATTC
*TATTGATAGC
AAAAATCTI
GAAT1'ACCGC
TTACCCTAAI
CGATGCG=I
AGAATTGAG'
AGATGATGGC
SAATGAGAGAi
CGTGTTTAA
C' TGAAAAAGCA k. TAGCTTGGA!
:TAGCGATCAX
'AITGCAACG,
STAAGATCAT'
~AACCCTAAA
PAAAAACCCG
CCTrAGAAGA
CTAAAGACGT
CAAGTAACGA
1AGTCAAGTG
TAAAACCCAC
TTAAJAGACGC
TTAGAATTAG
GATGAGCCGA
AGAGGACAGC
AGTTTATTTA
CAACAGGCAG
AGAGGAGATG
CCAGCAAGCC
GAGAGAGGAA
TTGGGGCTTT
CATGGACAGA
AATGAGCTTG
AATGGAAGCG
TCAAATCAAT
CAAAATGGAC
TTAGATAATr
GATITTTAGAT
GTGGGGGCGC
AAAXTCAGCC
ACAACGAACG
GCTATCTCTA
GTAGAGTTGA
ACACAAGAAC
ACACAAGAAC
CAAGAAACAC
GAAGAAGTT
CTITIAAAAG
AAAGAGCAAG
AAGGCTCAAC
AGAAGAGCTI
ATTTATCAAG
7GAACCCAGTI
:TTCATCGGCPA
r CAAGTCATCC
SGTGGGCAATC
r' AACGAGAGT;
-ATAGGAGCGI
k CACATCGCAJ k. GCAACAGGCC ,k ACCAATCAA2 r GATGACACC( P, CTTAAGAET(
TGGTATGAA
c AAAGACT=C T GAATAcTT7 C TATAGATTI T GAGAGCTTG c TATCAATAC' A CGCTATCAA G GATAATCT 'T AAAATCAAC
AGCAACAGAAT
ATGGAACTAG A AAGAGGGAAT G
TTGAGTCTAGA
TTTCAGAAGAA
GAGTATCAGCA
GAATGGAAAA T1
TACCACAGAC
CTCTCTCTAGA
TGGGCTCATr A ATAGACGCAG T1 CAAATCAAGA G
CAGTATI'ATT
TTAGAGACCT
TAGAAAGCTI C
CCAGGCTCFI'
AACTCCTI'AA
CTAAAAAAGT
AAACGCTAAA
ATAGCGTAGG2 ATAACGCTCA2
AAACCACACA
AAACCACACA
CAAITACGCC
TAATCAAGGG
AATTGCAAGC
AAATCCTAGC
ACCCTGAGGA.
XTI'GAGCGC
GTTTAGATCA.
*TAGGCACAGG
CAGAATTAGA
*AAAACACCGC
CTCCTrATGG
?I'CATAATI'A
TTGTGGTGAG
SAAAACGCCAC
CTGAACTTAC
k. GCTTCACTAA
TTTTTGCCT
'TCAATGCGGT
k AAATAGACAC ,k TTGATAAAGT k~ TCCACCACCC
AAACAAATGG
3 ATITATCCCA C ATAAGACTAC G AAGTITCAAAA T MTI'CCAACT T CTAAAGTCCA
TITAGGAGAA
GCAGGAATT
GAGCGATCG
GAGCAGGGA
TCCCATAGA
AGACGAT
GGAGCAAGA
,CCGCAATCC
,GAACAGCCA
=TTCCCACA
*GATAAAGCA
AGCGCAAGG
LCCTGCTCAA
GAAGAAAAC
;C~rAACGCT
GAAGCCATT
GACCCTACG
TTAGAGATT
"GCATTCAAT
kTTAAATCCC k.GAACAAACC k.GAACAAACC kGAGCAAGAC kGCCATCCCC
PGCTAAAACT
:AAACAAGAG
GCAATTTAGC
ATrTAAAGAA
A~AGAGACGCT
ATTAGGGTT'r CAAATTrATC
TCCTATTAGC
ITTAGAAAAC
CAATCATAAA
CTTITTTAGGG
TTCTTGGT'rr
CTTITTAGGC
GAGCGACATT
AGCTATGCCT
GCAAAACAAC
TGCAAACCAT
CGCTAACTT
TGGAAAGAAT
TGAAAACATr CGAACAAAr AGCGCTrhAAA
CCTTAAAACA
GCTTATCAAA
AGAACAAAAT
AGATTCACGA
GGAA'rrAAAC 120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1800 1860 1920 1980 2040 2100 2160 2220 2280 2340 2400 2460 2520 2580 2640 2700 2760 .2820 2880 2940 3000 3060 *9.9 999 o 9.
9 9 9 TITGCTICA AACAAGAA-A2 GGCTACAGCA CGCAAGATT! AGCATCAATC TCAACGA=C CTAGGGCATT TGAGTTTOGQ TACAAATACG ACTTGCAAG( CAAGCGATAG AAAAATTGCI GACGTTCTTA TTATTGATTI AATTAGAAA GGAGGGAAT AATGAAATGG GCA TTT CTAAAAGCCT ATITrAAAA TTGAATGATT TAACGAGCGC CCCrhAGCT CTGATIAGA GAATFI'GTCA
AGAAATTTGG
GATITGTATG
GCGCTAAAGT
AGAAGCGCTA
AAATGCAAAA
TTTI'GAAA GGACIT1'AAA TI'AATTGCAA GCATCAATCA ACAACCCAAA GTITAGAAAC GACCACAAGG ATAATGGCGG AGAAAACTCA AAGAAGTTAA GTGAAAGATI' TAGAGCTGAT ATCAACAGCC
CTTGGATACC
AACCATTATG AAAGCAATA GAAGACATCA AAATAGAACA TTAAACGAGC T=ATGGTAT GAACCTTT
TAAATAAAGT
GATCCTAATG
ACCCTAAAAA
AGACAAAAAG
CAGAA-GAAT'
AGAAGAACCC ATTTAGAGCA TATGATGGCT
CGCAATI'AGA
CAAAAGAACG cTATrrTTAG GGAGCAGGCA
AGACTTI'GTG
GTGAATAAAA CGCTCAT1'GC TATAAGGCTT
ACCCTAACGC
9 9 9 9 99 9 .9 *999 .9 *9 9 9 9 4. 9 4~99 9 ~9 9.
.9.9 9 9 9.9.
q9 9 99* 4 GAAAGAGAAC T CACACCCATI'
TC
GAGCTAGTGA Al AGAGAAACTA
A
AAATACGATG
CC
GACAATTI'GA
TI
GAAAAAATTG Cl AAAACCCGCT
AC
GCTAA~rCCT TC GAAAGAGGGT
T
TTTGAATTAG
A(
GATGTGCAAG GI
ATTTTAAAGCA
GTGGTGAAAA
C
TATAATGAAG
G
GGGCAAGACAA
TICATTGACC
C
AATATCTATGA
GGGCTATCCA C
CACGAAACTG
AGTTATGATG
AAAGAGAAAG
GATGTrTATA
C
GCTT1'CATCC
CGTGGCGGAGJ
CAAGAAAGAT
CAAATGGAAGC
TTTAGAATGA
ATCATAGAAA
AATCAAFI'AG
ACAGGCAATC
TCAAAATACA
ccCTAAAT
GTAATAATCC
GATTATGAGC
GAAGAATTAA
GAAAAGCTAG
GAAGAAGAAG
AAGTATCAAG
AGCAATATGG
GAGATCAAGT
AAAATCAAGG
T1'ATTCAA zCAATTATT GCTGAAA~z
JAAACCCAP
MATTTAGI
~GTGGATG;
GAcT'GC 'T1GCATCI
;AGTGAAA
%GAATTC7T
ACTTCCGI
:TI'AAGCA
TAACCCCC
AAGCCAAG
CTCTATCA
TATCCTTT
TAACGCTA
.GAATrATI
ACCCAAAA
AATAAAA
LAAAGCGCI
LAGCTAAAW
;CGATGT'J
aTGACGCT
L'CAGGGTA.
LAGTCGCT
'GcGTGGG kAATCTAT
CTAAATCT
AAGACTT
ccTrGAT1'.
AAGCC'FTC
TGGATrAT
CCACTCXT
TTATCAAA
CGCACAAG
ACGCTATI
ATTATAAC
TGCAGTr]
TTATAAI
TIGATGGC
AATTACA
GCTAGAAAAC
CTATCTCAAT
CTTAGGATTA
CATAGAACCA
CCCTAAAAAA
AAAAGGGGGT
CACGATI'AAA
CTATATTTTA
AGAAGCCATC
TATCCCTAAA
CACTCAGTAT
CGGCGATAAA
CCTAAGCGGT
CAGGCATAAA
CTTAAACAAC
AGAAATATTC
GAAAGAAGCT
AATCTATAAT
ACTAGAGCGC
AACCATCCAA
CGCTATAGCC
CGTGCCTAAC
TAATGTGTTA
TCAAATCGCTI
GTCTAACCCI
AACTTTGA2
TGAAAGAGCC
SAAAACAAGGC
SAGCCCACTI
;TAACCAACAJ
~AAACGATAA(
IGTATCACTD'
rTGATGATTCJ
CTCAAAGTTA:
CCATGTATAG
A CTTTGTGCC
AAGTGGCTCA
TTGATAGCXI
C TTGCACCAC
AAGTAGAAA.A
TAGAAACTC~
~C CCATAGCC
LTCCCCTAG
LA TCT1'ATCGC
~CGTCAATI.
LAAGGCATT'
A AACCGAAGJ
LTATI'GGGCA(
GCATGAA7 AT AAGGCAACI GC TTACGCCAI A.A ACGCATAG 'A ATGGCTA
ATTGAAGAAG
AA TAAAGAGC CT AAAACAGG 'C AGAGATCA GT TAAAGAGG ~AA ACTCAAAC
AAAAAGCAA
;CT TTAGAAJ
AGTTTAAGCC
AACGATACT
;TT TTTAAAAJ AAGAGGGCTA AAC GAGAATAAAA
ATC
GAAAAAGACT TTG AGGCAAGCTC AAG GAACTTATTA
TCA
TTGGAC'TTCC AT"l GAACTTTTAG
ACC
GCGAACGATT
A]
AATCAACGCG
TGC
GALTTTGAAAC
CC)
TTAGAAGAGTTJ
ATGACAGATT ACC GCTTATGAAG T GACAAGCCGC
AT
AAGGATTTGA
CC
ATCACTGATG AAi TTTAAAGACT
GG
GACACTrCA AC TTTAACTACC AT GACAGGGCGG
TG
AGCTGCATGG AA CAT1TAACCA AG GTTGTI'GATA
GC
AACAACAAT' Al AGAGGAATCA
TP
SAGGCAAGAAT
TV
TTI'AAAAACA
AC
TCTCATATI'GA]
STICAAAAATC
T
~GGCTCTAATC
G(
3AAAATCATGT 3CAACGCTATT
T
3GCTAAGACTTA TAAAATGCTTA
A
A GCTITTCCGC T AAAGTGTATGG A TI'CATTGGAG
T
CCAAAAATGCC
'A ACGCTAGAAA
AGAATTTTCTAA
,T GCCACTAAAG
G
LA AAAGTCAG~r LT AAAGCTCAAC :T CCTAGCAAGA
LGATGAAGAGA'
[GTCCAAATGG
C
.CAAAAGCAGG
3CCTGCTAAAA rAGATI'CCCCAT 3C AATATITI'AC CT GAAAAGACT1' AG CAATFI'ACAA GC TCTAATCCGA' Tc AAA TCGAGAG AT TACTTCAATC AA T1'GAAAGATT 6AG CTCTATGAT' ;TA GACCCTTTAA
;ACAAAACAAGC
Tr CAAGCAATI
ACAACGGCTTTG
:CT AAAGACAATC kTc AAcATGTFITA
~.CTTGGATAACC
TCAATCT
GTAAGGA
AAAAACA
CCAAAAA
CTAACGC
TCATTAG
:AAAAACT
.rGAGCGG
AGGGATI'
kCTGAAAT
L'TAATGGA
:AACTAAG
rTTGTTAG
~CTTATAA
GTTAAATA
3AGCAAAG
ATI'TATAA
AAC'ITTGI
ATCACCT'I
TGTTTAGP
.CAAAAACC
,CAATGGGC'
AAGGACAC
'ACGCTG'
GAAGAA'
GCTTATA
;TTGGATA
LATTAGTC
ILGCCTIIG
:GCTAGAG
L'TAACCG
%ACCCCTG
rGGGGAAC
TCGCTTTT
TATTGCT'
GCATAAAC
GGCTrTAG
GGGCAAG~
AGTGGCT]
.AAGCTATC
CACACAAC
'AGAAGCGC
LACTTFI'A(
LAGAAT'A
'AGCTAAA(
;TATCCCAI
kTTTGTT.
r'GGCGTA' 3GAGACCT
ACCAAAAT
ACGATAGC
ACGCGCAC
GCGAGATG
CCGAGATI
AAGAAAGC
TAGAAACC
TGAAAAA]
AAGAAAAC
AAATAGCC
TGAACACC
TCGTGAAN
CCAATAT
GCTCrA!
CTATCAC
AAAATAT
TGTTTATGAT
CATCAGACAA
AATAACCCCT
AGCTCAAATC
TA.AAGAGGCA
GGATCATFI'C
TATCTATAAA
CAACCTCAAA
AGAGGCTAAT
CATGCCTAAT
ATTGAGCCCT
CAATCTCAAA
A.ACAATGAA
AGTccCTTI'
*CGCCCAA'FI
CAATCTCGCC
*AGATTATTCA
*TTTAAAAACC
GCGCCCCCAC
CCATCAGGTT
CATCCGATTA
CGATGAATIT
CACTGAAAAA
[p GGTTATCGCG
LGAAAGAAGAA
~AAATXACCCT
SAATCCGTGCT
A. AATGGGGAT' A AACTTCTATG A TTTGCTTATT G CACGCCTATA A TGTCTTAAAA T GCTCAATGAT 'C TAAATTTAGC C TAATGATGAT c TATCAATGTG A AAATGGAAAA A ACCAAAAA GI GATTAC CC ;C TATCGCAAAA T TGCTTTCATA 'T AGATAACGCT ;A AAGC7TGTCT A GAACGAGCTC 3CTGTTCGTTT A AA.ATGAAATC
AAAAGCTCAAT
cC ACTAATGTG GA TGAATGTTG- GA TCCTGAAAAC CG TATGTGGCAA AA ATTAGGCT1'G AA AGCAGAAGCG
AAAAGCGAAGAA
:TT AAAAAACAAC ;CT TCAAAGATCC :A AGAAAGTAA6G Cc CTCTATGAGT :CA ACAAAATAAA :TT GTTTCTGAAT CC TTATAAAACT rC CTATAGCCCT
AATTICTGCGCT
TAA ACTCCCTGAA CC TAAATACACA 3120 3180 3240 3300 3360 3420 3480 3540 3600 3660 3720 3780 3840 3900 3960 4020 4080 4140 4200 4260 4320 4380 4440 4500 4560 4620 4680 4740 4800 4860 4920 4980 5040 5100 5160 5220 5280 5340 5400 5460 5520 5580 5640 5700 5760 5820 5880 5940 6000 6060 6120 6180 6240 6300 6360 6420 6480 6540 6600 6660 6720 6780 6840 6900 6960 kAA CTCcATTrGAA ATCACGAAAA
AGATTAGTGG
GATCATAAAA
GCGTTCAACC
TTAGAGAATG
GAGCCAGCTA
AATGTTGAT
AGCAAAAACC
CTCTAATAGA
CTAAATCTAA
AGAGGGAAGA
CAGAACAAGT
ACTACGAGAA
TTCTTACCCA
TGATTTAGCT
AGAAGTCTTA
GCAAGGGGTT
GATTGAAAAA
CGAACAAGAA
CGACTAGAAT
AAAATGAGCA
AAGAATTTGA
AAGGGGAACA
GAAATAGAAA
GTGGAAATTA
ACCTGCAAGC
AAGACAGAA
ACGCTGAAAA
CAAAGAGTCA
AAGGAGATGA
CTAAATCAAT
TrTAAAATGG
TTATAAGCCT
AAGAGCGAGT
TGATGAAATA
A.ATCGCTAAT
GGGTAGAAGA
7020 7080 7140 7200 7260 7320 INFORMATION FOR SEQ ID NO:1242: SEQUENCE CHARACTERISTICS: LENGTH: 1275 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .1275 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1242 AGGGAGGGGG CGATGAATTT AAAGTAGCCA AAAGTCTTGC AACACAATI'A TTACTATT *ATGTTTCAGT TTAAAACCGC AA'FrGGGGGA TT1AAAAATCC CCATCTGAAA AACTAGCCAT ACTAACACTA ATTTAAGTCC TATGCAATGA TAGTTAATCT CTCACAATGA TACCTAAAAT TAGGCT'AT TGCTTA'ITAT TTAGG TITAA TTGTATI'GCC TATCFI'AAAA AGCTCATITC TITAATTATG GAATAATCTA CAAGGCTI71r ATGGCA.ATGC GGCAATGTCT TAAAAGGAGA TI'AACCATTA TTGTrrI'AGG TTTATCAATA ATATCTrGG, AAAATTGGCA TGACAATAGG CAAGTTAAGC AAGCCTATCA AAAGCTTTTG GGCTTGGAGC GTAA.AGCTG GGGTGAAACA GATAAAAATA ATAAA
?TTI'GACACC
TGAACATGTG
ATTTATGATA
TATGGGTGTG
TAATGATTT
ACTI'ATCGCT
TAGTGAAAT
GTGGGATAAT
AATTATG'Tr
TGTGTTATTA
TTTAGGTTTA
CCTTACTCTI'
TAAAGTCAAT
GGATAAAATG
TTGGAACTCT
TTCTGTGATI
CACAAGTGGA
CGGAGCTGTA
GAGTGCTGGG
AATCAGTGGA
CTTATGGGTA
GGTAGCTT
TGGGCGTATA
GTI'GTATTTA
AACACTI'A
CAAAGCCTAA
TT1'AGCATAG
GCTITTTGATG
TTTTTAGTGA
GTTACAGCAG
ATCCCCCAAA
TATAAACCTI
ACITTTAATCC
GCAAATGAGG
TATATAGCCC
TGTTTCTTTC
GGCGTGGGGG
TFI'GGGGGTA
GGCGGACTAG
GGGGCAAGTG
TGTTTGTTGA
TTCATGCACA
AGCGTGTGAA
-TAGCGTITTGT
TTATCAATAC
ATGATGGCT
GAAA'FITAGC
GTM'I'AACAT
TTAGGGGA
AAATTTTTAT
CCAAAGGCAT
GTATGATGTI'
CCACTAAACA
GAAAAATI'AT
ATAGTTCTAT
TAGTCAAACG
CAGTAACAGA
GTGCAGTI'AT
CAGGACT1'CA
CTATGGCAAA
GCCATCTCAA
ACTCATTTTA
AGAGGGCGAT
AGGATTTATC
GATATTCTAC
AGAAATCCCC
CTCAAGTGCG
GTTTAATI'GG
ATI'ATTGTTT
GTGGTCAGCA
GTTA TTAGC
AGTAGCITI'T"I
CGAAGTCACA
TGATGTCTTI'
TGTAGGCTT
AGTGCCTGAT
AATGATGCAA
GG'ITGCTAAT
AGCTGGAGCT
CCACAGGAGT
ATT1'GATAAT 120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1275 CTTTGTAGCA AGTGTTAAAA GTGGCTI'GG; INFORMATION FOR SEQ ID NO:1243: SEQUENCE CHARACTERISTICS: LENGTH: 1326 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO Jvi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 1326 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1243
AAGGAGCAAC
CCGAATTTAT
TCAGACAAGG
AAAGCAAGCA
CGAGTCTATA
GAAAGTI'CTC
TACGATCTGA
ATICTAACCC
ACCCACCATA
TACGACCATC
AGAGAAATAA
TTTGAATCAA
AAACTAGAAT
TCAGCAACAA
ATGCATAGGC
AATAAGATTA
CAAAGCGCTA
GAAATCGCTC
GATGGGA.ATA
GAAAAAGCTT
GCTAAAGAGG
AATACAATAG
CAAATT
AAATGGCTI'A
TI'AGCATCTI
CCAATAAAAT
TGATTTCTAG
AGGATAATAG
GTGTTTATGA
TTGATAGAAA
ACACAAACAG
ATGAAACGCA
TTAAAGATAT
TCCCCAGTAT
TAAACAATGA
TI'GAATI'AGC
ATTATTA1'TC
TTATCAATGA
AGCAATTT
TACAAGAAAA.
AAGCAAAAAT
AAAGAGAAAT
ATAAGGAGCG
GTGGTAATGA
AGACTAATAC
CAAACCTAAC
AGATAAGGGC
ACAAGAGCCA
AGATCCTATI
TAAAGAAGAT
AGCGAATAAA
TATTGATAGA
CTTAAAAGAA
TAAGAAAGCC
TTACCAAGAA
TTCTAGCGCT
AAATACCAAA
TAAAGAAGTG
TTGGATAGAT
AAATAAACTC
CTTTAATAAT
CAGAGATTAT
TGAATI'GCAA
CAAGCC7" IFI
TTATGACAA
GCGACAAAAT
TrCTAACAAT
AAAAAGAAGT
GATGTTGCAA
CTCCCTTATG
GAATGGGCAA
GTCAATTI'CT
GAAGGGTTTG
AATAGAGAAT
TTGAAAGAGC
ITAGAAAATG
GTAGAAAGAA
GAGTATI'CA AGC TTFACAA CTGAATACTA ACGACAATGA
TAAAAGAATI'
CAAACAATCC
TCGTGAAAAC
AGTATTAAG
TTGCCAATGG
AAAGGCGCAT
TTTTTATAAA
AAGGGTI'AGA
GCAATGAAAT
CAAAAGATGG
AAGAGAGCAA
TGTI'GAAGAG
GCAAATCAAT
CTTTGAAAAA
TGAGATAAAA
CACTAAAAGA
AGAAATTGAA
AATCCAATI'G
CGTTAAAGAA
TGGATTGGTA
CAAACTGCCT
AGAAGTTAAA
ACAATTGCTT
TGCTTGGAAA
CAATAACGCT
TAAAGAAGAA
AAGTTTAGAA
TGTAATGGT
CAACAATTITT
AATCATTCAA
CCCTATIAAA
TATAATCATC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1326
CATAFTI'TAA
AAAGATGATA
AAAGAAAACC
GGTTCTAT TT
TCTI'TAAGAA
AAATACTATG
AAAGAAATIT
TI'GGTAAGCT
TCTAGTGCAA
ATTAITCAAA
TCCTAGAGCA
ATGCGAATI
ATCTCAGCGC
TAGGCTGGAC
GCGCTCTTTT
AAAGCG ITTA
TAAGAGACAC
TGAGTGCAGC
ATAACAATAA
ATAATGATAA
INFORMATION FOR SEQ ID NO:1244: SEQUENCE CHARACTERISTICS: LENGTH: 210 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. .210 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1244 ATCAAACATT ACAAACAATA TGGCACAGGC ITACATCTAT ITAGGCATAG TITGCAACA CTCATTIATC AAGAAACCCA AGACTITAGIT TTAACFI'CAA GGGCGTTAGG GCATAGCTCC TI'ACTCTCTA CTAAGA TTA TATTCATACC ACACAAGAGC ATAACAAGAA AGTGGCTCTT GTGTTI'GATA GTTTGATAGA GAACAAGAAG INFORMATION FOR SEQ ID NO:l245: SEQUENCE CHARACTERISTICS: LENGTH: 447 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) A.NTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION I1.. .447 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:l245 V .6 -00 0. *.0 .0
AAAAAGAGAA
GAGCATACAA
GAAGAACAAG
CCTAAAAAAA
ATTGCCTTTA
TTIAAAGAGA
AAA.AACACCC
GGCAATAATG
AATACATGCG TTTTAGAAGA GTATGGATI' ACAACAAATT CCCAAGATAC CCCCCTAAAA GGGGGCGTAA AAAAAGCTTG GTCCTIGTGT GATAAAAGAA CACGAAGCAC ITTl'ATTGAA AAGAGCAAAA GCT TITAAAG AAAACAATGA ACTTGAA
GTAAAAAGC
GATGAGCTAG
CAAGAGCCTA
TTAGATGAAG
CTI'AATGAAT
GAAGCGCTTA
CAACTAGAAA
ACAAAAATAA
AAAAGAAGTT
GCACAAAGGA
ATAAGAAAAA
TI'GCTAGA
TTAGGCATTT
GATTACAAAA
ACACAATAAG
TGAAGAACAA
AGTAAAAATC
GAGCTTTAAC
ATTI'GGCTCA
AAAACACAGA
CAAAGAAAAG
120 180 240 300 360 420 447 INFORMATION FOR SEQ ID NO:1246: SEQUENCE CHARACTERISTICS: LENGTH: 1119 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1119 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1246
CITAATACTG
GTI'ATAATGA
AAAGGTTTGA
GCTCCCTrAA
CACAATATCA
TTGAATAGTG
GAA.TGCGTAG
ATAAAATAAC
TAAGTGAGAT
ATAAAACT1'
TGGCAAAGCC
AAGAAGATAC
GTTGGAATTT
AAGAAGAAAA
TAAATACTTG
TA'FrAAGTrI'
AAAAACAAGC
TTTATTAAGC
GCTGACTAGC
ATCTAAAGAA
ACATAAACAA
ATTATI'ATTG
CAATTAAAAG
TTIATrAGCTG
GATGAAGACT
TGTAATGCTA
TTTCCGCAAG
GCCCTTAA?1'
ATATATTTXT
GAATAAAAAT
GGGTTrACT TAT1'GAAACG
AGGTGGACGG
AATATAGAGA
TAATCAATAA
AAAACTI'AT
GATTAGATrA
AGGTGCTACT
AGTAAAACTA
CTCTCAATAC
AAAGATTr
AGAAGACACT
120 180 240 300 360 420
AAAGATAAAG
AGGCAAAAAT
CAACTTCAAA
TGGCACGAAC
GAATATAGTG
AAAAAAGATT
ATGAGTGGCG
TCAAATAATA
AATATCAAAA
ATTCATAAAG
AFI'TGGGAAT
ATAGTTI'GGA
AAGAACTrGC
TTATGGCTFI'
CCATGCTTGA
GCTTI7GGGGG
ATGAAGGAAA
TTGAAGAAAG
AAAACGA'ITA
TTAAACCCTT
AAGAATATGT
ATTGGGGAFI'
GTATTAAGAA
AAAAAATAC
AAAAA.AAATC
TGAAATGAAA
GAACGCTTTT
TATAAGTAGA
GATATI'AGCC
CACTTATGAT
TAAAATTACT
AATGTCAAAC
TATGGGCTGT
TTTTGGTAAG
TA1AiAGTAAAG
TTATTCTATC
AAAGAAATTA
GAACACTCTA
r-ATAATGGAG
GAGAATACTT
TT1'GGCGAAA
ACTAGACAAA
TGGTTAAAAC
ACAGAGTTGT
AATATGGAAA
GCAAAAGTCC
TCCTATGACA
TCTCATCAC
AAGAAAAAGC
AAGAATITCCC
CTGAAAGTTT
ATAAAGCACT
GAAGTTATAT
CCTI'ATCTGC
CCAAATATCA
TAAATATGAT
TAGATGGTTC
CAGAAACTTG
ACACTACCGC
TAAGTI'TA
AAATAAAAAG
TATTGATGAT
TGGCA'ITAAA
TAGACAATAT
TATGGCTAAT
GCTCCATAGT
AGAGCTAACC
TAAATATCCC
GAGAAATAAG
TGAAATAGGA,
480 540 600 660 720 780 840 900 960 1020 1080 1119 9 .9 9.
bO *9*9 94 *9 0* 9 4 9 INFORMATION FOR SEQ ID NO:1247: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 693 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .693 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1247 .9 9.9.
9* 9 9
AAAGATTACA
ACGCATAAGA
ATCAGCCAAG
TTTGCTAAGA
'FTTAGTCCTA
GAATATGAAG
TATCTA "ITr
GAAATCTATG
TATGACATTG
?I'GAGTI'ATA
ATCAGCTI'AG
TGTITAAAG
AAACAAAGAA
TAATCTATAA
CTAGTTTAGT
TAAGCAATGA
TTGATIATGA
ATGXTIAGA
TAAATGGTAT
ATGAGTGCTI'
ACTTATTGCA
AACCTATAAA
GAAAAGACTA
AGAFTTTTAGA
AAGGGCAATA
AGACACCCCT
AGAGAAGTrA
GAATGCCCCT
AAGCACTAT'
ATGGCTAAAT
TAAAGAAAGT
X1ATAGAAATC
AGTTAGTA
AGAAATCAAA
TGACAAAGAA
GAGCAAGGGT
ATGAAAACAA
TrAAAGTTTA
ATCTTAGCTA
AAAATI'CT1'A
CCTAGTGATT
GAAGAAAAAG
GATGTAGAAG
GCTCAAAATG
AAAGGTTATG
GACTI'TAAAG
AAAGAGCCAT
ATT
TGAACTI'GAA
AGGATACACT
ATATCTTAGC
TTTCACGCTI
TrAAGCCTAT
AAGATAGGCT
AAGTGTTTAA
TCCTTAAAGA
CTAAAGAGAT
ACAAAGACAC
TTCTAAAAA
TGAATTTI'
AGAACAAGAA
CAATATGGTG
GATGTGTAAG
AGATGAAGAA
CTTI'AAI'TAC
TGAAAGTGTA
TAAA'FITICT
TAGAGAAT'1
CGCACTI'TAT
ATI'GCAACAA
120 180 240 300 360 420 480 540 600 660 693 INFORMATION FOR SEQ ID NO:1248: SEQUENCE CHARACTERISTICS: LENGTH: 1263 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .1263 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1248.
ATGAAAGGTI'
TTTGCAGAGG
ACTATCATAG
CAAGCTCAAG
ATTAGTAGTA
CAAATAGAGA
GCACAAAAT
GCTCTTACTA
GGCGAACAAA
GGCTATGGAA
TTGTGTAAAA.
AATAACCCAG
AATAAGCAGT
GAGTI'GGTG
GAAAATAAAG
GATAACGAAT
AAAGACGCTC
AAATATITAA
AGCGAGMTTA
AACCATATAG
TACITTCAAA
GAT
TAACAATGAA
GGGAAACTCC
GCAAAATGGT
TCAATCAGTI'
GTGCTATCAC
GCA'ITAGATA
TGTTAAGAAA
ACAATAAGAT
CCCAAACCGC
ACATGCAATC
TGGTAAACGA
AAGAGCAAAA
TAAAAGATAA
TAACTGACCC
AGACAGGTAA
TAGAACAAGA.
AAAGCCAAGC
AAGAAA ETAC
TGACAGATGA
ACAAACAATI
ACCCTAATGT
AAAATTAGTT
TIGATTGTC
AGATAGTATC
ACAAAAAGTC.
TTAGCCAAT
CAACTATGAG
CAAATACTI'A
TGTCAATCTT
AAGAGATGTG
ACITGCTGGG
TAGTAATTAT
ACGAAGATFI'
ACTTGACCCA
TACAGCTAAC
ATGCGACCCT
AATCCAAkACG
CTACGCAAAT
CAATCAAATG
TITATITTrAGG
AACGCAAAAA
TAAATI'TGAC
ITTAGCATGC
AATGACCCAG
AAAAGATACG
AATAACATGA
CCTATGCAAG
A.ATI'TAAAGC
CAGCAACAAT
AXAGATCTCA
CKAAATCTCA
GAATI'GAGTG
GAAAGCGAGC
TI'GCTTAGAG
TTTCTAAAAA
CATAATAAGC
A ITAAAAATG
CTCACACTTG
TTCAATCAAA
CTCTITTTAA
CAAAATAATG
AGAATAAACG
CAATTI'GGCT
TTTATGTTG
AAACCCATGT
AAGAGATTAT
TAAATACGAC
TTTTACAAAA
AAAGCATAGA
GCCCTTGGCT
ATAACCTAAT
TTCAGTCCAT
GTAGAGCGTG
AAGCTCTT
TAAAGAAAAA
GACTTGATGT
AAGGGATACA
TATTTAGGAC
ATTTAACCAA
GGATTAAATI'
ATCAAACAAT
ATGGCTTI'GG
AAAGAGAAAG
TTCCCATTTT
TAAAAGCGTG
AAGTCAAGCC
TTCTAAGGCT
TAAT1'CTrI'G
CGCTCAGTAT
AAATTGGAAC
TAATGTCAAT
CACCAAAAAT
TAGTGGCACT
GGGGGAAATG
AGCAACAGGC
GGI'AATGAT
CCTACAAACT
TTATGCACA
AACTCGCTTA
AGCCTCCAAT
ACTTACTCTA
GGCAATGCAA
GGAAAAAGAA
AGCTAGAATA
TAGTATATGG
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1263 A. *A 0
A
INFORMATION FOR SEQ ID NO:1249: SEQUENCE CHARACTERISTICS: LENGTH: 1338 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .1338 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1249
A
A
AAGCGTTGGT
CCTAACGAGA
TATITI'GACT
TrACTGCCTI'
ATGCTTAA
TGCGTCTTGA
GGGGTGTGTA
'ITAAAGCGTG
GGCTTGTGTG
GGTATTTCGT
ACC'rITrAGA
GGGGGGCTI'C
ATTATGCGAA
AAGAATGCCA
GCGCGGGGTA
TCCCTTCAAA
TGATTGTACG
AAGTGGTGCG
GCGAGCGTT
TCAAGTI'AAG
AGGITTTCGCG
CGCTCATTCT
AGAAAAGTA
TGGGGCGAGT
AACGAAGAAA
GCCTTATGAG
TATCCCTITA
TTAAACAGGA
TCTAGCAI'A
AGTGCTITAG
GTCGCTI'CTA
AAGCGT=
TCAGCGATTA
AMTTAGAGC
CATCATTCTA
AATGAACATG
GTT=CTCC
TTITAAAAAA
TGGAAAAGCG
AACATGCGAT
TAAATI'TGAG
AGAAATTTCA
CGTATTrGAA
ATGAAGTTAG
GTTTAI'GGA
CTTACTCAAC
AGGGGTGTCT
CGTGAAATCC
TTTAATGGGC
TGCTAATCAT
AGAAA'ITTTA.
AGATATGGCT
CTGGCGTGA.A
TITAGAAATI'
120 180 240 300 360 420 480 540
TTAGAGCAAA
GTAACGGGAA
ATI'TTAGC'T
CAAACCGGTT
GGCATTTCTA
ATTAAATACG
TITGGCACGC
GAATGCGGTT
GGCTTAAAAG
GTAGTGGCT
GAATACGCTA
TI'GAATCTTA
AGTITGCACT
GCGGTGAAAA
C7.-LrAAAAAA
TTCTTACGCC
TGGATrFTAGC
TTITATGCGCC
AAGATTTGAT
CTAATCGCAC
CAGGXI'TGTT
TGGXTTAT
ACTTGCCCGC
TTAATAFTGG
TTGAGACCCG
ACGCTCAAAA
TCACGCAFI'C
AATTGCGT
AACCCCTAAC
TTI'AAAAGAA
GAATFFITTAGC
TCATAAGCI'
TGACACGCAA
ACGGCATGAA
GCAATTITAC
CCATAAGAAA
TATTAATATT
AGGGATTCG
GGCGGGTrGC
GTCAAGCGAT
AGCTTGGTFI'
GTTTCATCAT
GCGCATGCTA
TTAGGGGGCG
ATCCCTCCGA.
TTTATTGATG
AGGAGCGCTC
GAAAACAACc
TATGGGAATT
CCCTATGATT
TCTI'GCGCGG
TTI'AACGCTA
CTGTGAGCGC
TGTGTAAGGA
ACCCTAAAGA
TTGGAGGGTG
GTTTTAGCGC
AI'TGCCTTr
TAGCGTATCA
TITI'AAGGGT
TAACGGCGAG
TACAGGGT
GGCCTTATGG
AACCCGGATG
TOCTAGACAG
GGCTTCTAAT
ATATAGGGCT
TTGCGAATAC
CGGTCT1'TTA
AGGGGGCGTG
AAGAGAAGAA
ATTAAGAGAT
GCTTGTGTAT
TCGTGTGGGG
TTAAGCTAT
GCATGXTTG
GCTTAGAGTG
CTI'GAAAAAA
600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1338 CATAAACGAT AI'IGATTATT INFORMATION FOR SEQ ID NO:1250: SEQUENCE CHARACTERISTICS: LENGTH: 1290 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1290 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1250
C
C
CC
C
TATGTGATAG
ITI'AGCCTGC
TrAAGCTCTT
TCTITI'AAAA
AATTCTGGCA
GTTITAAGCG
AAGGCGITTG
GTAGGGGGTC
AGCGCTTTA
C'DTAGCCGTA
GACGGCGTr
GCCAATGATC
CGCC'ITC'TrT
AAAAAAATGG
GATATTTACA
CTI'ATIGATG
GTGAGAAACG
AATITCAALAG
TTAGGAGATG
AGTITCAATG
GAAATIGATA
CTATI'CAAAA
AGCTTGACAT
TCGCTCAAAA
TAGAAATCGC
TCACACCCCC
CTAGCATGCG
GGGACAATTC
GGGCAAAGAT
CTTTAAAAGC
TITIAAGCGC
ACCACACAGA
TAAAAATITC
CGTCTAGCGC
TAAAAAATGT
GCGCTCATAT
TAGAGCATGC
AAATCCCCGC
CTAAAGATIT
CTTTAGGGAT
CGAGTCAAT
ATCACAGGAT
ATITAGAATG
AAAGGAGTCT
TAACGCCAGC
ACCTTGTTTC
TCAAAATFI'A
AACAACTATA
TTTATACAGC
CCTAAACGCA
TITIAGGGAGA
TGCGATTAT
CTTACAAGCT
AATCATGCTT
ACCCCTAGAA
GTFTITTA
C'ITGCTCAAC
AGAFATATGT1'
CCCITTAAAA
TF1'AAGCATC
ACGAGCCAAA
TGAGTGCGAA
AAAGCAGCAT
TGCGATGAGT
CGCGAACATT
CAATGGAAAT
GATAAATCGC
GTGCGGAATT
GGGGCTAAAG
AAAGAGCCTA
GGGCTITTAA
CGCCCCATGA
GAGGATAACC
GAAAGCCCTA
CAAGGCATAA
AAAAGTTTGG,
AAACCCCTAG
GCTCTCGCTT
CCCACTCGCA
ATCCAATCCA
GCGATCAGTA
GCTATGCTTr
GAAAGCGATA
GAXITTTGAAG
TTCTAAGA
TICGCTGTIT
TCTTTCCCAA
TCTCGCACAG
'TTTAATGGG
TGGAAAATAC
ATAAGATITTT
GCGCTCAAAA
AAAGAATCAT
A TFTGCCCC
TCGCTTCAGC
GCGCCTATAA
GGGCTAACAT
AATCCTI'TGA
GCGCGAITAC
TAGAAGCTT
AAGATTIAGA
TI'GATCAGAA
TTGCAAAAGG
GGATI'AAAGC
ACGGGTTITA
TTAAACCCCC
TAACTrAGC
CC=ITCAGCT
AGCCGTTATI'
AGAAGATTGT
CGCCAAAAAT
AAATTGCAAC
AGGCCTTT
TGAGCCITI'A
CTI'AGCGATT
TCAAGTCAAA
AGAAAGCGAG
TCAAAATCAA
CTFI'ACCATA
GCCAAAAAGC
TGAGGTIT1'G AGT1'ATTIGGC
TATCGCCAGC
CAAAAGCATG
GGTI'GTTTCT
TATAGAGGGA
TATTATCAAG
GTTGCCTITA
F1'GGCTCAAT 120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1290 INFORMATION FOR SEQ ID NO:1251: SEQUENCE CHARACTERISTICS: LENGTH: S76 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAMIE/KEY: misc-feature LOCATION .576 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1251 AATGCGCGAA CATTTCTI'C GTCTCAATGG AAATTAAAAT ATACAAATCG CTGAAAAAA AAAGAAATCA ATCGTTTGGA ATCCCTAAAA ATAAGAGCGT TACTI'GAAAA ATAAGGGGGT CAGCAAATTG TGGAATCCAT AACCACCCTG AAGTCAAGGG TCGTTAGAAG AATI'GCAAGA ACCAAGCAAA CCCCAAAACT
CCAACCTTTC
GGCTAAGGAT
TCAAAACAGC
GATCATAAGA
TAAAATCACT
GAGTAAAGAA
CGTGATCAGC
AAAAAAAITG
CTTGCAAATC
AGCT ITGGCT TATGGTTTr
TTGATTTI'TG
AATGTGAAAA
ACCCATGGCA
GACGCGACTI'
GGGTATCAAA
TATGCCACTA
CAACGGAAAG
GCTTCT
CAATCTATTC AAAAAAAGGA GTTTTGGCGT CAAAAGAGCG GCTCGCTCAT TCATAACGCT TTGAAGAAGA TCCTAAAAAA TTCCTAAACA GGAFI'IAGAA GCCCGTATGT GATCAAACCT TCGTGCTTI'T TGGGGACATI' ACCAGGCTFI' AGTCGTCAAT TGGC TTTAGT CTCTCAAACC 120 180 240 300 360 420 480 540 576
S
*5 5 .5*e *5 INFORMATION FOR SEQ ID NO:1252: SEQUENCE CHARACTERISTICS: LENGTH: 261 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION l.-..261 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1252
S
S
AAATI'ACCAA
ATIAACGATA
TTAATGGGCG
AGTAAGATrG
GAAGTGAACG
TCCACGCATr CGTTTTAATG TGTTTAGCGA TCCCCTCTAA AGTCATAGCC ATGTGGCACT CTrAGAGACT TTGGGCGTTC AAAGAGAAGC GAGCTI'GGAT AGTCCGTTAA. AGTGGGCGAT TATGTGCTAC TACACATCGG CTATGTGATG ATGAAAAAGA AGCCCTAGAA TCCAITGAGC TITACCAAGA AATGATCGCC AAACGCATGA A 120 180 240 261 INFORMATION FOR SEQ ID NO:1253: SEQUENCE CHARACTERISTICS: LENGTH: 738 base pairs TYPE: nucleic acid STRANPEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .738 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1253
AAAGGAACAA
AAAAAAGACA
ATGAAAGAGC
AGCGGTAAAA
GTAGAGGGCG
GCGCATCAGA
TTTGATTTAT
GTGGGGAATC
CTCTCTGTCC
GATGCGGTCA
GTCAAAGAAG
GACCCTAAAA
CAATCCACGC
GCATGAGCGA
TCAAAATCGT
GCTACCTTAA
CCACGATGTT
ATTTGCAAAC
TCACCACCGG
TAAAAGATGA
TGGITTTGCCC
CAGAGGGCGA
TTATCAGTAA
ACATGCAAAA
GCTTGGAAGA
ATTCGTFI'
ACAACGAAAA
GGAAAAGATT
AGAAGGGTCT
AGAAAATCTA
CAACAGGGAT
CGAAGCGTGC
GGGAGCGTTA
CTCAAGCTAT
TGATAAGGTG
GGCGGACATG
ATTAAAGCCT
GAATCGTTAC
TTGAGCAAGA
GTATGTGTGA
GCGGATI'TA
GCGGACAGGT
CATTGGAAG
GAAAAAAGCG
AATCTAGGGG
CTAAAATACC
ATTGAAGTGT
GAAGCGCCCA
AAAATAACCC
ACGACATTAA
ATITCATGAG
AAGAC1'TTAA
TGCGTAAAAA
CGAGCATGAT
AITTTAAT
CGGCGATGAA
CTACGATGFI'
TTAATTFI'AG
TTIT AAT
AAAAA.AAGCG
TAATTTGAGT
AGCCGCTGAA
TTCTCCCGGT
GTTTTGCGTG
AGGCGTGAGC
TGAGGGGGCG
CAITGAAAAC
TATCGTTTTA
CATGTGTGCG
GGTI'TCTCAA
GAGCTCCAAA
TGAAAATTAC
120 180 240 300 360 420 480 540 600 660 720 738 a a.
a TTITAAAAAT TTCCTITTTAG INFORMATION FOR SEQ ID NO:1254: SEQUENCE CHARACTERISTICS: LENGTH: 2871 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1. 2871 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1254
GGAAAAATAA
AAACTCGCTG
TTTAAAAGCT
GCTTITTAGAG
GCTITTATC
CATTTGTTAA
TGGCAAAGAA.
AAGAGGAATI'
T1'GATGATAA
TGCTTGTTGC
AAAAGCATA
AGAGCCATT
AAAACAAGAA
GAACGCTAAC
TAAGGAGCTI'
TATTTAGA
TI'CATI'CGCT
TAAGGTAGAA
GTAAGGAATA
GAGATTAACG
TTAGATTACC
GACTTCAAAG
AATI'GCGAT
AATCATTGCG
ATGAAATTIT TGTCGCTCAA ATCCGTITAGA AATGCTIGGAC AACAGCAAGC TTTGATTAAC AAAGTAAAAA AGAATIITAC TCGCTAAAAA. GAAACTCAAT TGCGTTTTGA AAATr'rCATC 120 180 240 300 360
AACCGCCTAG
GTAGAGCTTT
TTTAGCGCGA
AATAAGGACT
TTTI'ATCGTG
GATTTAATGA
AATGGGGAAA
AGACAGGCGA
'FrCACTGAAG
AAACTTGGCT
GAAT1'GAAAG
TI'AGGCATGC
TTCACGCATT
CGCGTGATTG
GAATTAAAGA
ATTGAGGTCT
TTITATGCCA
GCTTTCAAGC
GAATGGATCC
GAAGAGAGCT
GCFTI'TGACA
CT1'GATGATG
AGCGTCAAAA
AAGCTGAAAC
AGCCTTGAAG
CCT1'GGCGTG
TACCGAAAAG
GAAAAAAATT
TIAAAGCATG
GCGCATTTI'A
ATI'AAAGGCA
AATGAGAAAA
ATTCAAACCA
AAAATCGCGC
TrCAAAG'rrG
AAAGCCAAAA
TTAGAAGAGT
AGCAAGATTG
AGGCGCTTT
TTCATTGATC
CTFI'TTGAAG
TTAAAATTTT
CC'FITTACAT
TAAGCGTGGC
ACGAGCATT
ATTCCAAACA
CTCCAAAAGA
GCGATGAAGA
AT1'ATGTGAT
TTITTAGCCT
AAAGCGATCT
ATGGTAAAGA
ATFI'AAACGA
AAAAACGCTA
CTGTGAACAT
AAATGATGA
ATCCGGAATT
TTAAAGAGAG
GTAATGGGCA
TCAACACGAG
GTGAAAAATT
ATITCAGCCA
CTGGGTGGGA
ACGCTAAAAA
ACCAACGCCA
CAAACGCTGC
CGATITI'AAA
AAATCAAATT
AACAAACCAA
TTAAGGATTT
AAA'ITTATGA
AAAAGGTATC
AGCTATACCC
TCGTGCXITT
TCCAAGAAGT
AAGGCGAGAT
GTGATGCAGA
ACTGCGATTG
TGTI'AAAGAT
ATGAGCATTT
TCCCTGA'TT
CTAAAGGGAG
ATAAGGTTT
ATGGGGATAA
GGCCACAGGG
TATGGGAATG
AATCAAGCAA
AATTGATFTC
'ITCTTTAATG
AAGCAAGGAA
TTTAGATGAA
GCTGTCTTTA
CATCACTGCG
GTCTGTTTTA
CAGGGAAAAA.
TAAAGTAGAA
GGAAAACAGC
TGAGAGCGAT
CCTFTTTTAGC
TITAAAGGGC
TAITGAAGTC
CGATAXAGTC
AAAGAGCGTG
GATI'GATAAG
TAGCACAAGG
GCTGGTGAAA
AAGGTTAGCG
AATGCTGGAA
GTTCCAAAAA
AGAAAAAACG
CGCTCTTAAA
AAAAGAGCAT
CCCTAAAGAT
AACCTGGCAT
TAATCAAAAA
TAAAAGGGTT
GAAAGAGCAT
CGATCCTI'AT
GCTGTTAAAA.
GCTTAAGCAT
TACCGAAACG
AGACAATTTIG
TATCITTTGG
CAAACACACT
TAACCCTAAA
GGATGATGTG
AGCGGTAAAA
GGF1'TGATCC
TTTGAAAAAG
AAAAACCTTA
AAAGAAATCG
AACCTTI'TA.A
GCGCATAAGG
AAAGGGTITT
GTGTATAATT
TTGAAGAAAA
GAAATCGCTC
GGCTATTI'TC
GATGCGGAAA
TTTTCAAAAG
GATGGCAAAG
ATGGATI'TTA
ATCATTAACC
TTTTGCCTGA
AAGGTGGTGA
AGCAGTATCA
CCTAGCGTGA
CAATCTTTTG
TATTIAGAGA
ATGCITI'TTG
GAGAGCGAAA
CGCATAGAGC
AT'FTCTCAAA
TACGCGCTGT
TATAAAGAT
GTGCCTAAAG
AAAGTTAAGG
GCGCCTITGG
GATACAGAAA
CTCAAAGAGC
GTGGTTAAGG
CTGCAAGAAA
TTTATI'CCCT
CTGCAAAAAG
GAT1'ACGAGC-
GACGATCCCA
GGGGAGCGT'
CGATCGTCAT
CTAAGAAAAA
AAATTGAAAA
AAAGCGTTAA
CTCFI'TFITA
ATTATAAGGA
GGAATAAGAC
TATTCAATTI'
TGAGCGTGGG
ACAACTI'AAA
TTTTAAAGGC
ATGACCCTTT
TCTIFITI'AA
CTAAAGACGA
ATAAAGAAAA
AAGGCTTAAA
CTAAAAACAA
'ITAGAATAGG,
GTAAGAATTT
ATATCTI'AGT
TTF1'ATTITT
GCAGGGGCGT
TAGATGAAGC
TGATACCTAC
ATGGGGGTGA
ATGCCTTATT
GCGCTTCGTI
TGAGTGAAAA
TAAAAGAAAT
TAGATTACAT
ACGAGTTTAA
CGGATAAAAA
ATAAAGAAAC
AACACAAACA
ATI'ACTACAC
TAAAGAGCGA
ACTATGATFIT
ATATAGACAA
GCGGCACGCA
ATAAGGCAGA
ATCTCAAAAT
ATAGGGATCT
TATCAAACTG
TATCATGFT
ATACAACCGC
GAATAAGGAT
TTACCGCGCA
TTGITGGGAT
TGAAAGCAAA
CAGCGCCACT
CGAGTGGGTG
CGCTTITAAG
GTTATTGCTT
AATGCTCGTG
AACTI'TAGCG
TTTATTAGAG
AGACTATAAA
AGAAGCAGTI'
CCAAGAAATC
CGATATTACA
GAGCTTCAAA
GGGGTCTCGT
AAATATAGGG
AAGGATTGAA
CATTAAAGAC
CAACCATGCA
GAATAGAGGT
CGTGCCTrGC
TAAAATGAGC
GCATTTTATT
GATACAAACA
GATTTCTGAA
CGCCCTAGAT
AGAAAAATI'G
TT1'AAGAAAA
AGACAGAACG
CCCGCTCAT'
GAGCGATTI'
'ITGGGCGTTC
CGCTACAGAA
GATCATT'GC
TGCGTATCAA
CAAAGTGGT
T
420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1800 1860 1920 1980 2040 2100 2160 2220 2280 2340 2400 2460 2520 2580 2640 2700 2760 2820 2871 a. INFORMATION FOR SEQ ID NO:1255: Wi SEQUENCE CHARACTERISTICS: LENGTH: 747 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .747 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1255
TGCATGCGTT
TTAGACATTA
GCGAAAAACA
GAATTTCAAA
GAGCGTTTGA
ATGACTTCAT
TTAGAAGAAA
CTAGAAAAAG
ATGATAGGCC
GTGGATITCA
CTAGATGGGA
TACACTTATA
CATGTGITTTT
TTTATTITAA
AAGGCAGCTC
GCTTACTAGA
AAGAACGCTT
ATAGTATTTA
TCATCAATIT
ACAAGATTTA
GGCGCTTGAA
AAAATCAAGT
TI'GTCCCAAG
TTTTTGGAGC
AAAGCGCGGT
TAAGCGGTGT
ATTCCTT'GG
TTCTTATATC
CAACGTI'CAA
GATTTTAGAA
TCCTTTAGAA
AGAAGACACA
TGGCCTI'GTC
CGGGTrI'TTG
CTTIAGGCTT
CGCTGAAATC
GGGGGTGTT
GTTGAAAAAC
GAAAAAC
CTTTTAGGGA
AGCGACCGGG
GCGTATTT
GCTTTAAAAC
AATCCAAAAA
CACAGCGTTT
TCTCACAACC
AACGCCCACA
ATAGGGACTA
AACATAGGCG
GTGGGTGAAG
GC'TTTI'AA
TTTTTCTTAT
'TAAAAGCGC
TTCAAGCCCA
TAGAAAACC
TGACTTATAC
CTCTCAACCC
AAGCCATAGG
AGCGGTGTGC
ATTI'CAAGCA
ATCAAGTGCT
TITCAAG COT
GCGAAGCCAA
TTTTATITT
CTTGATGAGC
AAACATTAAG
TGXITTGAAA
CCCTACTFI'C
TATTGTGAAT
CATTGCCGTG
TTATAGCGTG
AGAATTAGTC
AACGAGCGGG
TGAAGATCAT
ACTTTTAAGG
INFORMATION FOR SEQ ID NO:1256: SEQUENCE CHARACTERISTICS: LENGTH: 462 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAM~E/KEY: misc-feature LOCATION .462 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1256 a.
a a a a a. .a S a..
a. 9aa a TGGTA'FFTrA
TCTAGGAATT
TTICTCACTTC
CCTGAACATT
GCGTI'GGCA
GTI'TCACTAT
AATI'GGTGGG
CAAAAGATTT
AAAAAGAAAG
GGTCTI
5
IAAG
TIGTCATTAC
TGATTGGGTG
AAAAAAGTAA
TGCTTGGCGC
CTGTCTTI'
TITITGGTAA
AAATCCCATG
GAATAGGGGC
AGCGGTTAAT
GTTTIGATT
GAITT=IAAA
TI'TACCAGCG
TATAGAAGCG
ATATTGGGTG
GTTATACATG
AGGCATTI'G
AGAAGTAGTG
TCTTTTAGTG
ACCCGCT1'TG
CATTTATT
GGAGCTGATC
GATCGCTATI'
AAAAAATCAA
CATC'ITCAAG
CAGTTGCTTG
GGGAATFI'GT
GAATTTCTAT
TI'GTATGGTTI
TATTGGTGGG
AT
AAGCCGCT I'
CGTGTATI'I
GTTATTGATG
AGCAGACATG
TGTGAGCGGC
TGGCTTATT
CTGTGTGATA
INFORMATION FOR SEQ ID NO:1257: SEQUENCE CHARACTERISTICS: LENGTH: 228 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscjfeature LOCATION .228 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:125 7 TGGGCGAAAG GCGCTGGGGC TTI'AGTGCT1' GAAGAATACG GCTAAAATI'T ATGCAGAATT TGCCGGGTAT GGCGAGAGCG GCCCCAGCCC .CTGAGGGTGA AA~GGGCTTT AAAGCCATGA AAAGTGGAAG TATGCTATGT GAACGCCCAT GGGGACAAGC AGAGCCGAA AAAAAGAGGG GCGATGCTAA CCACATCACA AAATGGCTI' AGAA.ATGGCG
ACGCATTA
INFORMATION FOR SEQ ID NO:1258: SEQUENCE CHARACTERISTICS: LENGTH: 333 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .333 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1258 9 .9 9* 9 9999 9.
9 99. 9
ACGCCCATGG
GTGTTTGGCT
TGCTTGGGTG
ATCTTACCTC
CCTAATACAG
GGCACTAATG
GGACAAGCAC
CTAAAGAAAA
CTGCGGGCGC
CTACCA'ITAA
CCAGAGAAAA
GTGTTGTGAT
GCATI'ATAAC
AGTCCCTCCT
GTTAGTAGCC
TCAAGAAACG
GCAAGTGAAT
TTTCAAAAAA
GAT1'GGTATG AAAGCATTGC GTI'AGCTCCA CTAAAGGGCA
GTTATTTCTA-TCATGGCCAT
CCTGACCCAG AATGCGATCT GCGGTGATGA GTAACTCATI'
GCC
GTAAAAAAT
GATTGGGCAT
GAATCAAGGG
GGATTATATC
TGGTI'TTGGT
INFORMATION FOR SEQ ID NO:l259: SEQUENCE CHARACTERISTICS: LENGTH: 567 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc_feature LOCATION I1.. .567 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1259
GGCCCAATAC
ATGCTTTTAA
TACCACATGA
ATGGGGCGTr TTTAATrrrG,
GCGTTI'GCCA
ATTAGAATGC
GFFI'AGACC
ATTAGACGGG
CCTAACGGCG
AAAGCGCTCC
GTGCTGATGc
ACAAGCTT
TGGATI'CCTT
ACAAACCAAG
AAAGCATCAA
AAAGCTCTTC
CTAACATTTI'
TGTCTTTAAA
AGAGCCTrAG
AGCAATGAAC
TI'TAAACGAT
TTTAGAGCGT
AAAACTACTC
CGTGTTAAAA
CAATTCTTI'G
AGGCGAGAAT
GATAGAGACG
GGAGTGGGAA
TTI'GAG
AAGCTTITTT
AAGATTGAGA,
TTGTT1TAAAA
AACACTCTCA
ATCACTITCA
AATATGATGG
GTT'FFITCAT
ATGAAAAGGC
TACGACTTTG
TAGCTrTTAT
ATTTAATGGG
ATCGTAAGGA
AAGAAAACGG
AGGCTTCAAG
GGTATTCGTA
ACGAGCTTAA
ATGGTITGA
CCTTACAAAA
TG'FrGGGGGA
GGAGCGATCC
TTTCTATGAA
GCTITIATCG
TAATCCCCTA
TGTl'TGCCT
AACGGAATAC
TTTATGGAT
GATCAAGCTC
120 180 240 300 360 420 480 540 567 INFORMATION FOR SEQ ID NO:1260: SEQUENCE CHARACTERISTICS: LENGTH: 963 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) AN TI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (iX) FEATURE: NAME/KEY: misc-feature LOCATION .963 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1260 *5
S
9* S S
S
*5S* eq S
ATGGAACAGA
AAAGATATTTr
CAGATTCTAA
AATATCCATI'
TFI'ATACAGA
GACAAAGTGT
GAAGAAACAG
ACTI'CA'rTAT
GTCATTATT
CAAGAACGCG
GAAGAAAAA
CAAGGCAAAG
A'TrTGGGTAG
AAAAGTTATC
CTrXITC2'TA
'ITATACGAGC-
CAA
ATAAAAAAAG
CTGGAACGGC
AAGAAGTTGG
CTATCTI'GGA
'TTTTAGAGCA
GTGT'rrTAA
CAAAAAAACC
CCAA.AAAATC
TAGTGGTCGT
CTATTAAGCC
AGTTAGAGCC
AAGCGATCAA
AAGTGAT1'GA
CITTAGAGGC
AAAACAACCA
CAAATAAAGG
TTTAGAAAAT
TTTAGAAGAA
AGCGGCAGAA
AAAGCGCTAT
CGAGTATAAA
AGAGGGCGTG
CCTTAAGGT
TCCAAATGG
TATCATrCAA
CGACACCAAA
AACGCCTAAA
AGAAAATCCT
ITI'AGATGAG
TAAAAACCAC
TCAAGAAcAA
TTTAACGCTC
TTAGATCTTT
TTATCGCFI'A
ATTTGCAAGG
GAGTCrFI'AT
ATTGATTTGA
GGAGAAGAGC
GAATTGGATr
AAACCCTI'TG
AACAGCTCT
CTGATGTrCA
AAAATTTAGA
CGACTAAAAT
CAAGGGTGCA
GCGCATGGGT
AAAAACAAGA
AAACAITI'CT
TAAAAAT1'G
CGCTI'CTAAA
TGCTAGGGGT
GAAAGAATr
AACAAGCCCT
TTATCGrI'IT AGGGGTGGTT CTTTAAGA AGAGAGAGAG 120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 963 AATAATI'CTT
TCAATGAAMC
TrAGAAGAAA AACACAAAGA AATACCA'rrr ACATTATCCC AAAAAA.AACT CTIITCAAAA CGCTI'GTI'GT TACGCTTTGG GATIATAACG ACAGCAAAAC ATCAATGAGG
CCCAATACAJA
TAATCCTACA
ACAAGACAAG
TAAACGAGAT
GGTTTAAA
GCATGGGCAT
TAGGCGGT
AGCGCTCCAG
INFORMATION FOR SEQ ID NO:1261: SEQUENCE CHARACTERISTICS: LENGTH: 345 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .345 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1261
AGGAGTGGGA
GTTTTGAGTA
AATCAAAACG
TTITATGATG
ATCGCTCTTA
ATCATITTAA
ATACGACTT
GCGATCCTGT
CGTA=AAA
AAAACTTAAA
ACTTGCTTGA
AAAATGGGAT
GCCTTACAAA
GGAGI'TAAG
AATAAGCTCC
GATCATTCAA
TGGCGTGCGT
TAGCGTGGT'
AGATCAAGCT
GAAGCGAGCG
AATAACCCTT
ATCATTGCTA
TI'ATCCATA
TTI'GATGCGA
CCCTAACGGC
GGAAATATTG
TGTGGCAACC
AAGAAAACAG
TCACTGACGC
TGCCT
GAGAGCCTIA
GCTGAGCGTG
CAAAATCATT
ACAACAAGAA
AAAAAACCCT
120 180 240 300 345 INFORMATION FOR SEQ ID NO:1262: SEQUENCE CHARACTERISTICS: LENGTH: 615 base pairs TYPE: nucleic acid.
STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION .615 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1262
CGGTCTCTAG
ATCGTFI'AT1'
(;TTTATTTGG
CTCAGGCGCG
ATTTTATGT1'
AGGGCTTGGA
ATCTCTTCTA
TTTAACAATT
AAGGCGCTTA
TTIGATCTTAA
CGTGCTGGCT
FTTTCAATAA
TGATGACTTT
AGATGCAATC
TAATAAAAAA
AACACCAGGT
CAGCCCCCTI'
TGGGCGCGTI'
TCGCCACCGC
AGCGCAAGGT
AAGAI'GAGT
GAGCGGGTT
ATGGGTCTIT
TTTGTCTAAC
AGAAATGATG
TCTTAAGCAA
TATTGGTTG
AdGTCAPAGCT
TGCAGGGATT
GTATGATI'TA
CTCITTTAAGG
GT1ACCACGC
TTGTATAAAA
ATTCITAATG
AGACCAAAAG
AGCACGACAG
TTTGGGACGG
TCTITI'GGAG
TTAGCAGCCA
TCGG'TTATG
GGATAATCAT
TTGTTTTAGT
GCAT1'GTATT
GAGCGCAAGA
GTATICTAAT
GTFI'AGTGGT
TAGTI'GAAAT
TGATCGCACC
TTCCAGCCTA
TGCAGATGCA
GTTCGA 1TCA
TTGGATTTCG
AAAGATTGAA
CGCTCAGAGC
GAATI'GT1GC
GTTGAGCATT
TTI'AGAAGCG
CATTATTICT
TTCT1'TTTAC
AGTGGATATT
TI'GTCTTCTA AAAAA INFORMATION FOR SEQ ID NO:1263: SEQUENCE CHARACTERISTICS: LENGTH: 408 base pairs TYPE: nucleic acid STRANDEDNESS: double
I
TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .408 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1263
AAGGTITI'TA
CCTTTAGTGG
ACCTATAAAG
AAAGTGATAG
GAATACAACT
AGGGTGAGTA
ACGATTAAAG
TGAAT2TACGA
ATGTGATGCT
AAGAGATTGC
AGATACGCAT
CTI'TCCCGGA.
TCCGTGCGGA
AAGCGGGGTT
TAACTATTGG
TGTI'TTA'rTG C ITGCCTTCT
GGATAAAGAC
CACTI'TCAAT
CAAGCGATTG
TTTGAAAGTT
GATGAGGACA
GCTATTCTTA
GGTICAAAAA
GCAAAAATCT
TTGCTTTCTA
ACCTATGACA
TC'TrAATCA
AACCAGAACT
TGGTAACGAC
CTGCTAGAGC
ATATAGATAG
AAAAATACGA
AAGTGATTTA
CAAGTCCT
CAATATCACG
GCCCACTCTC
CACTCAAGAT
TCAAACCTAT
TAAAGATACT
TTGTTAAAA
INFORMATION FOR SEQ ID NO:1264: SEQUENCE CHARACTERISTICS: LENGTH: 384 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEAXTURE: NAME/KEY: misc-feature LOCATION .384 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1264 00 0
AAAGTAGGGC
TCTTGCTCT
GAGAAAATCC
GATCTGCCAA
TrTTTTAGAGC
TCTI'CACTCA
ATGAACAAGA
CAATIGCAT
ATGCTFI'GTr
TTFTAGATTT
GCGAGAAAAA
CTAA6AGAAGA ATGA TTTCA
AGAACAAAGG
GAGTAAGAGC
ATTATATGGT
AAATAAAAAG
GAATGAAAAA
ACCCAAAGAA
AGAAAGACAG
CGTT
GCGATFFIG
TTGTITGTTAG
GACGAACAAG
ATTGAAAAAG
GAGCCTGAAG
ACAAAAACGC
TI'CTITCTGG
AAAGGCATAA
CCATTGACTT
TAACGGAAAA
AAAGCCTI'GA
TCAAAAAGAC
CTTTTAGCG
TAAAGAAGCA
GAATrAGAA
ACAGGGCGAT
AGATATTT
GAGCAAAAAA
120 180 240 300 360 384 INFORMATION FOR SEQ ID NO:1265: SEQUENCE CHARACTERISTICS: LENGTH: 645 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: risc-feature LOCATION 1 645 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1265 GGAAGAACAA TGAAATATTT ATGGCT17T1:7.
GATAAAACGC TAGATATIAT TAAAACCATT TCCATAGATA ACGATGCCAA TTACGCITTA AAGACTAGCC AGCATTGA TGITTCTCAA GAACTCAAGG ATAAAAAAGT CCATCTTGTA AATAAAATFT CACGATTAAA ACTTTATGAT GACTACCCCA TTGTAAGTFI' AGATCTATAC GTGAATGA LT ATTI'AAAAGC CCCTTCTATC AAATACATIG GACCAGGAAT CACAAACATC AAAGAAATCA TCAAAAACAA CCGACTCAAT ACGGAGTIT ATI'ACACGCA GATGGCGGAA.
TTIAATATACG
CAAAAACTI'C
AAA ITGCATG
AACAAAGAGC
GCGCTTGTGA
GTGGATACAG
CCITITGCAG
GCTTGGATGA
GCACTAGCGG
ATITI'CCCCA
AAACGCCCAT
CTATAGGGCT
CTAAGAT'GA
AAGTCII7AGC
AAGGTGCTAT
GCGTGGCGGT
GAACGCTCAA
CGCACAACAT
AGCGCCTGAT
ATTATACGAT
AATGGGCGAA
GGTr
TTGCAACA
AGTGCGCTAC
GAACGAI'TA
CAATTIACGCA
AGAAAACGGC
AAAGACTI'
GGCCAI'GTG
TGTTITI'TCT
GCGTTATCAA
CGCTGAGCAA
S. INFORMATION FOR SEQ ID NO:1266: SEQUENCE CHARACTERISTICS: LENGTH: 342 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .342 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1266
S
TTCCTGAGGG
GGGGAAT'TG
GTI'GAGATI'G
GTTACTAATG
GATGACAGAG
AGGTI'AGCGG
GGAAGTITAT ACAGGAGAGG GGGTGCTTTA, TGGGCATAGC AAACCGAAAA. CCAAAAAGAG AACGGGTGGA TATTTI'AGCC ATGATGCTAT CTCTAGGGCT TCTCTAGCGT GCTGGCTAAG
TTAAAAGCGT
AACATGATCA
CACATTGCTA
GATGGAGCGG
AAAAAGCTI'
ATTGAGTCTC
TGTGTTGCCA
CCTTGCITCA
TCAAI'GGGG
TCTATIAA
TAGAGGACGC
Tr
AGGAGTGGAA
GGCGGGAGTG
TI'ATGCAGAA
AAAAGGATCA
AAGCTCTGAC
INFORMATION FOR SEQ ID NO:1267: SEQUENCE CHARACTERISTICS: LENGTH: 297 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .297 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1267
AAGCITAGCA
AATAAAAATA
CTAAATTCCA
TTAGCCAAAA
CAGGGCCACG
TGAGAGCGAT
TGATTGATI'
AGCTCTTTGA
AFI'ATGGGGC
ACTITTAGAAG
CGCTATI'GTT TAGCCAGAA ITI'CAATAAA CCCATGCTCG AAAAGTGTIT ATCTCTAGCG GAGTFTI'TTG AATTTACGCC TGATGGCCTA TCACATGAAA
GTTCCAGTAA
CTTACCCTAT
ATAGCATGGA
CTAAAAATT
GAATTAGAAT
AAGGATTAAG
TGAAACAGCA
GTATGTCAAT
AGCAGACGAG
TAAAAGA
e. a.
a a a a. a a a, aa INFORMATION FOR SEQ ID NO:1268: SEQUENCE CHARACTERISTICS: LENGTH: 768 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .768 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1268 a.
a a
ATCCCTCCGA
TATGGTAAAA
TATI'ATGATA
TATGGCGTGC
ATI'GGCTrGT
CTAGGAGTCA
'FrGCATAAAG
GGCTITGCTC
GCGATTI'AG
AGGGGTITTAT
GTGGCTI'AA
TTTAAAGAAG
GAAGCGATCG
GCACACCT
TAAATACT'G
AAGACATTGA
AAGGAGAGGC
ATCAAGGGAG
AGGAATTAGT
AAGTGTTAGA
ATGGTTTTAG
TCGCACCAAA
ACCATCTAAT
GCTATGCTAA
AATGCGAGAG
TAAGAATGGG
TCTTAACATT
CTI'AAACACG
TFI'AGGCGT
TCAAGCACTC
'TfTGAGCGTT
CCAACAATCT
AAAAGAAGTG
CGTGCATITC
AGGGCCCGGG
CGCCATAGAG
AGCGATGGGT
CGATTTATI'C
GTTTGAAACT
CTGCATGTI T
CTAGGAGATI'
ATCCAATCCT
AATTTGAGGG
TCAAAAGCAA
GATGTGATCA
ATCCCTTITT
AATCAGGTTG
AGCGCTTTAA
CAAGAAAGCT
GGGGGGAGAA
GGCGAGCAAG
TTAATCAAGG
TI'AAACATTA
TGATI"I'TGGC
TACAAGTGGG
ACTCTAAAGT
AAAAAGAGGG
TGGCGTTACT
TAAAAGAGGG
TCTCCCAAA
GAGAAGAATA
CAATTCATAA
TGGGGGTF1'T
CGGTCTI'GTG
CAGGATAC
TCGCTCCCAT
ATrACCCGTT
CATI'ATTGGC
GAAGGTGCGT
CTII'GAGGTG
TCCGGATGAA
GCAAATTATA
AGGCGTGGGC
CCTI'AAAAAT
CGCTAAAGCG
AGAAACGAGT
CGGGGGGTTA
120 180 240 300 360 420 480 540 600 660 720 768 INFORMATION FOR SEQ ID NO:1269: SEQUENCE CHARACTERISTICS: LENGTH: 273 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SEN'SE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .273 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1269
CAGACGAGCA
AAAGATGAAG
TTACAAAACG
TCTCCCTITA
TTAAAGAGCA
GGGCCACGAC
ACATTGCGTG
CTTTGAAAC
GCGCTTCGCC
TTCAAACACG
TTTAGAAGTG
TTGTTTGTAT
TTTAAAACAA
TATCGTTCT
CGCACGCAAG
ATGGCCTATC
GGCGI'TCAG
AATCAAAATA
TrAGCCTTGA
ATC
ACATGAAAGA
TATTFI'TACA
CGGATTATGT
AAACGGCGT
ATTAGAATTA
AGAAAAGCAT
TITCACATGC
CAAATGGCT
be..
9 S
OS*G
09 C C Oe**
C
CC C
S.
CCC@
INFORMATION FOR SEQ ID NO:1270: SEQUENCE CHARACTERISTICS: LENGTH: 936 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .936 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1270 Vsee* b C S *06
ATGAAAAGCG
GGGTTGATTT
CGAAAAACCG
GCTGGGGGAA
GCGGTI'GTTT
GGAAACATTT
CTAAAACAAG
GAATIAGGAT
AATGCGCT1T
TATAGAGAAA
TATCAAAGAA
GCTAACCCTA
AGAGACCATG
ACCTCCTTAT
ATAAACCCTT
TCGCGCTCTA
CTAAAAAGCA
GCGGTAAAAC
CTAGAGGGTA
TAGTI'CCTCA
CGAGCGTGAT
CAAAGATCGT
TAA.AACCCAA
ATATTAAAAG
TCACCTCTAT
GCAGGCTTGA
CCCCTTI'GA
TGGTI'ACTTC
'FITAGAACGC
TCCTTITCT
TGATI'TAAA
GCCCTITCAT
TCAACGGGAT
AAAAACAGCG
TGTGAGCGAA
GTIT'TAGAC
AGTCCCCCCC
CTATAAAGAA
CACTAACCCC
TGCGTTITA.
T'ITGAAGCTT
AAAAGATCTC
TA TrrI'ATG
TAATCTATC
ATCCCCAT'A
TTAGAAATCG
TCTAAAGGT'
GGCGATGAAG
AA.AAGGAGC
GATGGTTTTA
TACTACCCT1'
GCCCATTTAG
ACCAAACGCA
CCCAAAGAAG
TTAGAAAAAG
GTCAAATTAC
ACCCCACTCT
AATGTATTGC
TCAGCATAGG
CTCCAAGATA
TAGTGGTGGT
CCTATCTTTT
TAGGCGTTI'
GGTTTAATTT
TTI'GTI1GCC
TCATTACAGA
TGCTITIAGT
TGGTTAAAAA
AGTTTTATCA
AAGAT1TGCAA
TTITGCAAAAG
CACAAI'AAA
CAACTTGATC
CCAAGAAGTG
GAGCGTTAAA
AGCCTTAAAT
AAAAGCCCTT
CAACCAATTC
TAGCGGGITG
AGATAAGGAT
AACGGCTATC
ATTGTXTT
AAATAACGCC
ATTGCCTTI'A
120 180 240 300 360 420 480 540 600 660 720 780 840 AGCGTATTGG ATTTAAAACT AGAAXITTGC CCTAAAGTTT TAGAGGAGAT
TGATCGTTAT
ATCC TTT CTT ATCCTTGTAA. TATAAAAGAA CATCTA INFORMATION FOR SEQ ID NO:l271: SEQUENCE CHARACTERISTICS: LENGTH: 591 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAMEIKEY: misc-feature LOCATION .591 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1271 a.
a a. a
AAAGTGTTGT
TGGTCTAAAA
GCAAGAACCC
CTTGAACCTT
T1'TTTGAGCG
TTGCAAGCTG
TCGCCCCT
GGTATCAGTA
GCGATCGCGC
TACATGGTGC
GGGTGCTATA
AATCCATGCT
CACGAGCCGG
TTGAGATGCC
GT TTI'AGA
TAGGGGTCGT
TI'AGCTTGCC
ACGCTATI'AA
TTI'AGTCAT
TTGGGFFI'AT
T1TTI'TAACC
CTFI'GTGGAT
GGGGCTTGGG
TITrAAGGGG
AGACATTAAC
TTGCATCATT
TrATITCATC
TATCATTGAC
TCATTATATA
GGTGTI'AAAT
AGTI'TATTA
AACGCTAATA
ATCTTCITTT
CCTTI'TGTTT
CTTCATTAA
TCATCAACGC
GC'TIITTTAT
GGGTI'TAACG
GACCCTAGCA
ITCCCTI'CAG
TTI'GCTCTFI'
AAATCCAAGG
C11TTTGCGTT
TCTTAGGGCT
GCCCCAAAAT
CTTTAGTGGT
TCGCTA'rITT
GGCTI'GCATC
GTrTGTCTTG
GAAAGATTT
GATTGTTTTG
CTI'ccATCAT
GGCTTGTTAT
ATCGCTAGTG
ACGCCTTATT
GAGCGATTTI
TATGCTGGTG
TGGGATT1GC
TTI'GCTCGCT
T
120 180 240 300 360 420 480 540 591 a INFORMATION FOR SEQ IT) NO:1272: SEQUENCE CHARACTERISTICS: LENGTH: 489 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .489 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1272 CAGTTTGTCT TGITTGCTCG CTIACATGGT GCTTGGGTTT ATGGTGFIAA
ATITCCCTTC
AGGAAAGATT TITAGGCGA TGGGGGGGCG TA7TrrTGG GFITGGTGTG CGGGATFI'CT CTCTTGCAT TGAGTrTIGGA GCAA.AAAATC AGCGTGTITI1 T1'GGGCTCAA TITAATGCTT
TATCCGGTCA
ACCATGCCGG
TTCAATTACC
'FAATAAGCG
ATCGcATGcT
CGGGCGTTT
TAGAGGTGCT
ATA.ATITGCA
CTAACCCITI'
TTrTGTFI'CG
ATTTAATAGG
TTTAGTATC
TTTGCACACC
ATGCGCGTTT
CTTGGACGCT
CTATGCTTAT
cT1'AGGCGCA
CTTTTAT'IA
ATCCTTATI'C
TATGCGCTCA
TTGAATAGGC
AAATAAAACG
AATICTTGCA
TATGCAACCT
TTGTGATTAG
AAGTTTGCGC
CCA..A?,tit
ACAACGCTCT
GCC'FrrTAT'
CCTAGTCITTT
TAGAAAAG
z4U 300 360 420 480 489 INFORMATION FOR SEQ ID NO:l273: SEQUENCE CHARACTERISTICS: LENGTH: 270 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .270 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1273 00 00-0 0..
ATGAATAAAA
AAAGTGATCG
TACGATATAG
GACTGCGCGA
AGCGTGGAAA
CCATAAAAGC
CAAGCGGGGT
CGCTCT1rT"C
TACCTGAAGA
ATAACGCGCA
CGCCGCCCTA GCCTATAACA GGGCGAAGTG GCTAAAAGGA TAACCCCATG CTGGTGGATI ATIGTATGAA AGCGTGGTGC
A.ATGTCCA.AG,
TGGGGCAAGA
TCA'ITCAAAA
CGCTCTTAAA
AAGTGTTITT
TCATGCCCCA
AGCTAAGGAA
GGTGGAATI'A
ATGGCTCAAC
0.* 0. INFORMATION FOR SEQ ID NO:1274: SEQUENCE CHARACTERISTICS: LENGTH: 855 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .855 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1274 GTCAAAAAGT CAAATAACAT GGTAGTAGAA TTAAAAAACA TI'GAAAAGAT GGGTTICATG CTCTAAAAGG CGTGAATTIG GAATI'GAAAA AAGGCGATAT ATAGGCTATI CAGGGGCGGG GAAATCCACG CTCATTCGCT TGATCAAT1'G CCCAGTTCTG GCGAAG'rITr AGTCAATGGG GTCAATCTGT TAAACTTAAA
TTATGAAAAC
1'I GGGCGTG 'rFTAGAGCGC
GCCTAAAGAA
'TGcCAAAAAG
AAAAACGTGT
ATTAAATCAA
TATCCTAAAC
AATTGCCCTA
CATTCTATIT
ATCACACACC
GCGAAATCG
ACTAAAGAAT
CGCATCGTGT
CGCGCCAAAA
TTGAAAACGT
GGGTGCATGA
AGCTCAGCGG
ATTTGTTGCT
TAACGCITCT
AGATTGAAGT
TAGAAAGAGG
TGCTTGGCAT
TITTTAGGGGA
AATAGGCATG
CGCTTTCGCT
ATTGTTGGAA
CGGGCAAAAA
TIGCGATGAA
AAGCGGCATT
GGTTAAAGAA
CTCGGTGGAA
CAAAAACGAA
GCATTI'AGAC
NITTTCCAGC
CTAGAAATCG
TTAGTGGGGT
CAACGAGTGG
GCCACATCCG
CAAAAAAAGT
TTGTGCAATC
GAAATTTTTG
CATGCGGATC
GAGCCGATCA
ATTI'CAATFI'
CCCGATGGGA
TAGAAGATAA
CGATCGCTAG
CTTTGGATTC
TTGATTTGAG
AAATGTGTGT
CTAACCCTAA
AAAAATCGCA
TTTCTAATI'
ATI'GAGCGCT
AAAAACTAAG
AGTGCATTIT
GAGFFI'AGCG
TAAAACCACG
CATCGTTr C
GATCAGCAGC
ACATGCTGT'
AGACATI'TAT
GATCAGGCGT
300 360 420 480 540 600 660 720 780 840 855 TTTAAAATAA GACGT INFORMATION FOR SEQ ID NO:1275: SEQUENCE CHARACTERISTICS: LENGTH: 441 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .441 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1275 0 009 .09 0. .9
TTATTITGCT
AGCATTATCC
TTAATGGAAG
GAAGTCATI'A
ACTITAXTI
GGGGATTTAG
GTGGTCGTGA
CGCTTGAGAA
CCTGCCTITA
CGTTAGCCAT
TAGAGCATGG
AAATGATGCT
CTCTAATAGW
CCATTAGGAT
TCATCGTTTr
AGAATAAGTA
TCAGCGCTTT
'TCGGCCAT
CAAGATTGAA
TTTAGAGAGC
CTAT1'CGGCT
TGGCTATCAA
AGTGCAAATC
T
TTGATTGGCA
CCTITTGTIG
ACCACTTTAA
CTGCCTTCTT
ATGGCTGGAG
AGFI'ATAGGG
ATTCAAAGCG
CAAGCATTGG
TAAAGC "iTi'
GCTTGGGGGC
TAGTGAATAA
CG'ITAGGGGC
GCGATGTGCT
CGGGGGATI'A
ATCTAGCGCG
TGAAAATTCT
GTCTCATTTG
TATCACCATC
TGGGGGATTG
TrrrTATGCG
TGTGGTGAAA
INFORMATION FOR SEQ ID NO:1276: SEQUENCE CHARACTERISTICS: LENGTH: 837 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY:i'-ircular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc_feature LOCATION .837 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1276
TCTI'ATTTTT
TCTCTCTATA
AACAACATCG
TI'GTTFI'ACC
GATGGCATGG
GGCAGCCCTA
CAAGTCCAGC
GAGCAGGGCA
GAAGACACCA
CAAACGACTI'
CTTCATTCTA
GGCAACCCGG
GTGAGATIGG
TCTAAAAGCA
GTTATAATCT
GTGCCACTI'C
ccAATGTCAA
AAGCGATGCA
AAGTGGGCCT
AAGAAACGGA
TTCCTGATGG
ATCTTGTAAC
CGCAAGTGAA
CTAACGTGAT
TGGGGGATAA
ATTCTCAAGG
TAGAAGAAAT
TI'CAAACCGC
TAGGTTGTTA
AGGGATGCTC
TACCACCGGG
ATACGCCGGC
TGGCGTACGC
GAATAATI'TA
CACTACCGCT
AAGCGAGGGC
TATCGGTGTG
CGGGCAAATC
TTGT'TTCC
CFI'AGGCAAG
GACAGATCTA
TGATGCCATG
AGTTTAGTI'A
GCCCAACAAA
TTTAAAAAAT
ACCAACACAA
CCTAGTGCGA
GATATTGCTA
TACACAPAGGA
TATCTCCTCA
GATGGCACGG
ACTI'GGCTA
ATCACCAACG
TTAAGGCAAG
ATCACCGCTC
CTCCAAACAG
AAGGGAAAAC
CGCACATI'GA
CTCGCGCGGA
GCAACACGAC
TTACCAAAAT
TTACAGGTAA
GCGGGAATTT
TCCCTCAAAT
TGAGCGTGAC
AT TTTGTCAA
CTAGCGGCGA
GCT1TTGGA
AAAGGGCI'A
TCAATI'CCCT
CATGCTCCGC
CACCACTTCA
TT1'TAACGAC
TTTATCGCCA
GTITCGCAA.
AGGCTITT
CAAGCTAGAC
CACTTI'ACCC
TCAAGGC TTG
TCCGGCGGGG
TGCGATTGTG
GCTTAGTAAC
TGAAGCCAAT
CAAACGC
120 180 240 300 360 420 480 540 600 660 720 780 837 0* C 9
C
C C
CCCC
C
C
C
INFORMATION FOR SEQ ID NO:1277: SEQUENCE CHARACTERISTICS: LENGTH: 948 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genbmic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY; misc-feature LOCATION 1 948 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1277 AAATGGCGCA ACTCATCAAG CGATAAAATG GATATTCAAG GCGTAGGCTT AGAAT1'GATC TGTGAGCCGT TGTATCTCGT TCATAGCGAA AACGCTTATG AAACTAAAAC GCTATGCG AACTCTAGCA CGATAGGCAA AGTCAGCACT AAAAAGGCTI GCGAGTTGGC GGATAGTAAA AACAAACTCG CATGGCAACA AGCTCAAATC CAACGCTACA AAGATCATCA ATrATTATG CTAIT1'AGCG ACCATGTGCC TITAAGCGCG GTTAAGTTFI' TATTAGCGTIT TCAAAAAAGC TCAACCCCC ATGCGGGCGA. AGAGGGATTG GCCAT1'CAAG AGAGCAACCA AACGCTAGGT GATAGCGCTT TrGCCCCCAA TAAACGCAAA GATGTAGGGC TAGCCCCTI AAAAGCGCTC AACGCTCCCA TTTTACGCGC TTCCACTGAC AATAAGGCGA ACCATAAAAG CTATI'TGAAC
GCTAAAAAGA
TTAAAAAGCC
CTTCTAGAAC
ATCGCTATTG
CAAAGCGGGG
GAAGTGGATG
CCTTTTGTGG
ATGCT1'GGGT GTT TCAAC
ACTCAAGCCA
TI'TGGGGAAG
TTTrGAATGCT
ATAACCCCCT
TATFI'TGATG
CACGGCACGG
GCGATCAAAT
AAATTGCGAT
ATAAGGAAGT
GAGCCAATCA
ATGCCCCTT
CGTATAGCTT
GCATITGCAC
GGCATACCGA
GTTCAAAACT
TCATTCAAGT
AAATCGTTCA
AAGATGAAAA
TTTTGGGGCC
TTTATGTGAG
AAAGCATCAA
CGTTTGATAT
ACTITGGCT
CAGCTGTGGG
GAGTGCACTT
ATTGCTTGAT
ACCCTTATTA
TGAGAG'TI
TTTGCCTATC
TTTTTTGAAA
CTTTGTGGGG
GAAAGCGTTA
AGTGTGTGGT
GATTTTAAAA
ACTGCCCGCT
CATGAGCCAT
TGTGAGTTTG
TGCTTATCAA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 948 INFORMATION FOR SEQ ID NO:1278: SEQUENCE CHARACTERISTICS: LENGTH: 1062 base pairs TYPE: nucleic acid STRANUEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .1062 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1278 CAAGGTATAA TTCAAGCAAA AGTTCTI'GCG ATGACAGCTC a a 9 9 a a a
CATTTTAAAA
GCATCGCGCC
AATAAGGATT
ACTTTAATAG
ATTTGGAAG
CGCATGCCTI'
GATTIATGAAG
GATAAGGTTT
GCCCTTGAT
CCGAAF"ITGG
AACGCCCATA
GCTATCGAGC
TTTGGCAITG
TGTGCTGAGT
GCCATGATAG
AAAGCCGATA
TCTCTCAAGA
TGCATGCTGA
T=CCAAAAT
AGGGTTTGAT
ATCATTTGAG
TAAGCGTGCT
ACAI'AAAAT
CAAAAATGCT
ATGCACACCC
CTTTAGTTT
ATTI'GAACGA
A'TI'AATCCA
TGGGGGGAGC
TTGA'FIGCGA
GGCGATCAAG
TTTCGCCAAG
AACACCACCC
TTI'AGCCCTI
AAAGCACCAC
GA.TTTGCCG
TAAAGCCATC
GATGGCAAAA
AGGGCATGTG
GCTAGTCTCT
CGTTGCCACG
TGATITAGGC
AAACGAGCCT
TTCAGGTITA
TGAGGTAAAA
GCAGACTAAA
GAGCCAAAAT
GCTTGTTTA
CCTAGAAGCT
AACGCTGT'A
AAAGATAAAG
ACAAGAATAG
AGCTCITATG
CTTTTATTAG
GCTATCACTA
GCCTI'GAGCT
TATTCGCTCT
GGGGGGCAT
AGTTTAGACG
TATCCAGGAG
TTAATG'ITCC
AAAAATGCGG
CAAAAGAT1'G
CGCTATTTIA
CTAGCCTI'AA
GCCCCTFI'AG
TATCAAAAAA
AAAAATTG
ACATGATTTI
AGGACGCCAA
GGGGCGTI'GT
AACGCG 1TAA
ATCAGCCAGG
TGTCTrTGAA
TIATCAATGA
CTTTIAATTT
ATAGCTTTGG,
GCCCCATAGT
CTATCCCTIT
TGCGTFI'GGA
GCTATCATTT
AAATCAAACG
GAAAGGCG T
AA'FTIGCAG
AGCGCTTTAT
AG
APAGCATI'GAA
GCTCATCGCT
GCCTGAGALW
AATAAGCTTG
TTTGAGCGTI
TFI'ACCCTIG
AAAACAAACC
AGAGGCTAGA
GGAGAGTTTT
GGAAAAAFI'A
AAAAAACAGC
GGTTGAAAAA
TCAAAGCGCG
CCCTAAAAT'
TGAGGATTTG
CGACAATGCC
CCCTITAGAA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1062 a. INFORMATION FOR SEQ ID NO:1279: SEQUENCE CHARACTERISTICS: LENGTH: 768 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOL~OGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NQ (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .768 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1279 AGGAATAATA TGGCATACAA ATATGATAGA GACTTGGAAT Tr'=TAAAGCA ACTGGAATCT AGTGXTTTAT TGGATITGTT CGAGGTGCTT GT1=GTA AAGACGGCGA AAAAAGACAC AATGAAAAAC TCACAAGCTC CATAGAATAC AAAAGGCATG GCGATGATTA CGCTAAATAC
GCAGAAAGAA
AAAGGTGAAG
AATTACAACA
GAAAGAAGCC
ATAAAAAACA
AAAATGGGAG
ACCAITCTAG
ITIITAACAG
GG%-CCGGCTT
ACGCAACAAG
TCGCTGAAGA
GAGTCTTATA
AGAAAACTGA
TAGAAGAAAT
CGGACAAJTTT
GCTFI'AAATC
GGCGTGGTT
GCCCTGTI'GG
ATAGGGTAAC
CCAATGAAGA
GTTGCAATAC
CAAAGAGATI
AACGACTI'TA
GGATGATGAA
GAACAGACAA
TTATCAATTA
ATCGCTTGCG,
CTGGATCAT
CATACCGGCA
TAAGAAGTCG
TATGGGAGCA
TTATGCGATG
ATTGAACAAA
GAAGTGAAAG
GCCTTAAGCG
GCTGTCATTG
GGCAATCAAG
ACAGGCGTAT
TGCATI'GTGG
?I'GCAAATAG
ATAGTITTGC
TGTGCGATAA
ACATGCTTTC
AAATGTGCGA.
CGGCGACTIT
TTGCGAATGC
TGCTTACAAG
GGACAGCGAT
TCGCCACT
AATCCGTT
GAGTTTCA LT
ATTAAAGGTC
TAAAATCTTA
TGAATTGTCC
AACGCTGTTT
GGTTGCAAAA
AACTCTGAGC
TGATATTGCA
ACGCCTAAAA
INFORMATION FOR SEQ ID NO:1280: SEQUENCE CHARACTERISTICS: LENGTH: 303 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .303 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1280 *9 9.
9
GTIATAATAT
TTAGAGTCAT
CAGAGACAAA
TCCGGTAAAT
'FIGGCGGCTA
CGA
TITTGCTATT
TITTTGTGGGT
AAGACATGGA
CTITTACACCA
ATGTITTTCT
GTTTTI'?IA
AATATTGACC
ACAACTTATC
AGAAACACAA
CATTGGTCTG
GGAAATAAAG
ACTTGGTG1'
AATGGGATTG
CAAGCAAATA
GTTGTTITGG
Tri CAGTAT
GITTGGTCAT
ATAGGATTAT
AAACCGATAA
CTGTTTTTCA
TTA TTGCTT
GCATGAAGAT
TAAAGCAAAT
AGCATGGGAT
CATGATCAAG
120 180 240 300 303 *9 9 a INFORMATION FOR SEQ ID NO:1281: SEQUENCE CHARACTERISTICS: LENGTH: 354 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY misc-feature LOCATION .354 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1281
GCGGTGAAAA
TI'AGTGATCG
CCTCAAGTGG
ATCGCTATT
TTAAAACACA
AAAAGC.AATT
AAGTAGAATC
TGCTCACAAC
ATAAGGATAG
CTAATAAGGG
AGGTI'TCCAC
TGGACAACT'
CATGAATGTG
GGCGTCTFTT
CACTGATTCT
TTCTTTAT
TTTGGCTAAA
TATCAAAGTG
GTGCCT1'TCA
GTGCAAACTT
AAAGATGTGT
TTGACGATA
GACACCCCTA
GTGGATTTAT
TTGACATCAT
CAAAGCTTCC
TGGACAAk7AA
AAGAAATCAG
TTGTCTTGCA
TGCAACTAAC
GCFI'GTGTTG
TATTAGCAT'
ACAAGTTACG
cTTTGAAAAT
AGGCGATAAG
AATC
INFORMATION FOR SEQ ID NO:1282: SEQUENCE CHARACTERISTICS: LENGTH: 336 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .336 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1282 S S S9**
S
S S *5 S fl
*S
*5*S
S
55 CTACACAGAC AGGCGCAAGT ATTGGCTCAA ACGCCCCI'A T~ATGGATT TAGGCTCAGC CTI'GCTITAA AAGCGACCGG AACTTGTTAG TGAGAAAAAG GT1'GATACGC AATCCCATGA
TAGAATIAGC
TATCGGTCI'
TTCTGGCATT
CATGGGGTTA
CGAGATTTTA
GGTTATAGC
CTTACACAAA
TTAGGGACGG
GACACTAAGG
F1GGTAGCGA
GTI'ACCAAAT
AAAGCC
CGACGACTFI'
TTATGGGGAT
CGATCATGAC
TCCCTGCGAT
GGGATATI'
AGTGGCCACT
CATGCTCACC
TAAI'TAGCC
TGTGATTI'AT
CCACCATCCG
INFORMATION FOR SEQ ID NO:1283: SEQUENCE CHARACTERISTICS: LENGTH: 417 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .417 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1283 AACCATAAGA 'ITAGGGGTTA TGAAA.AACGC ATGGCATTAG ACAA.AAGGAT TIGGATGCAT TTTGATCTTT TGCCTTTTGT GTI-1TATCATC CCCTITGTTGG TCGTITCTIT 7=~TTGATT m
ITTGAGAGTA
CTCTTTGGG-
TATTGGGCGT
GCGCAGCGAT
AAAATCGCTA
GTGCGGTT
TAGTGTTTT
GCGTTATTr
GGCTAGTCAT
TTCTTTTATT
GAGCTI'GAAG
TATCCCTTTC
ATTAGCGITA
TCCTTTCACT
GT1'GGCGCGA cAAGGGGTTT
AGGAAACTCG
GTGGATTTTA
TCTATCACCT
TT1'GATCAAA
ATI'ATGCCAT
ATCGGTGGCT
TGGGATCGAG
TACAGCCTAG
ATCAACCCAC
AGGGTFTCTI'
CTTTGCGCTI
CAAGCTTGGA
CGAGCCTGTG
CTCCTT
INFORMATION FOR SEQ ID NO:1284: SEQUENCE CHARACTERISTICS: LENGTH: 930 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION I. 930 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1284
C
4 4 44 *4 *4 4 4 4**4 04 C 4*
TITTGTGGGA
AAAAAGAAAT
ATCTGTGCGT
GCTAAACAT'
GATGCGTFI'G
GTCAGAGCCT
GFI'GAAGG'T
AATAAGAAAA
ATGATAGAGG
CT1'ATCCCCA
TATAAAATGA
GCAGGATTGT
CTI'AAATI'CA
GAAGGCATTG
GAAGTCAAT'
AACTTGGATA
CACTAAAGGC ATTGAAGATA
GGAAGA'ITCT
TAAGGAGACT
GGAATATCCC
TCCAAGAAAC
ATGTGAGGGT
TAGAAGAATI
GGCATITCT
AATGTAAXAC
TACCTTITAG
ATGACGCTTT
TAGGCGTAAC
'ITCCTGTI'GT
GGTTTGCGTA
TGCCTGGTGA
CAATCAAAAA
'rrrAAAACAC
TCTCTAGGG
AACGA ITGTC
TAAAGGGATC
CAATTCCGTT
GGTAGATGAA
GAGTATTCAA
CA'rrATCCAT
CGATGCGCTC
TGGAATGGAT
CGCTGTCGCG
GGGGAGTGTT
T1'TGAAAGTG
AGTI'GGCATG
AAGATI'ACCA
TTGATGAAAA
TrCAAGAGAG
GTTTCACAC
ATAGACGAAG
GCC IICAT
ACGAAAAAAT
AGAGTTAAGA
GT'IGCATCAG
GCTATCGCAC
ITGGATAAAT
CAAGTGGGGA
GCAGGGGGCG
CTAGAAAAGT
ATCACTTCTC
CGACACCATG
AGAAGCCATT
AGAGAGAGT
ACACTCAAGC
AATGGGGGTT
T1'AGGGGGT'
GCCTTTCAGA
TTCAAGAAAG
GCGCTGCAGG
CCAT1'CAAGC
CTGTGGGCGC
GGACTCTCGT
CAACCGCTGC
GCFI'TAATGA
TCTI'TAAGGA
CAAAGCATTA
GATGTGGCGT
ATTAAGCTI'C
CGAAGCCGGC
TAAAGGTTT
GAAAGTCCCT
CGCTGAAAAA
AAAACAGGCT
AGTTGCTGGG
AGGGATGATC
GAGTTTGGTC
TAATGGTTTC
TGTTATCACA
TGAGACGGGT
GAATTATCTC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 930 *4 4
ATTAAAACCA,
INFORMATION FOR SEQ ID NO:1285: SEQUENCE CHARACTERISTICS: LENGTH: 1257 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: mijsc feature LOCATION 1 .1257 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1285
ATGAGGTCTT
GCGGTTTITA
GAAAATACAG
TCAGTGGGCT
TATCGTT1'GA ACCCACTA T
TACAAGGGCG
AATCCTGTAG
AGCCCGCACC
AAATTrrAA
TI'AGAAGATG
TCCAGGCCTA
GTTAGAGTGA
GAAGATGTGA
ATCGCTCAAA
TATTATAAAG
GCCATGGGTG
GACTCITCGG
GTGTATCGT'
CAGTTCGTGG
GATAAAGATG
GGATGAAGAA
TAGGGTGITC
ACGATAA.GCT
TI'GAATGGTC
AAAAAGACTC
ATGATGAGGG
ATAAAATTTC
AAAGCGTGTT
cAAATCCCAG
ATGTGGGGGC
GGCAAAAATA
GCGTGATAGT
GTCAAAACCT
TAGCTI'ATCG
CCACCAACAC
TCGTCGCCGT
AAACCTCTGA
CCI'GATCCA
F1GAAGCCAA
ATAAGGACAT
GTI'AGAGTC
AAAATACTTC.
TTCTACCAGG.
CCCAGTGGTC
TAAAGTCGCT
CAAGCITAAA
G'rTAGAAACA
CAAACTI'TCA
TGCAAGCCTr
CGTTTCTAAA
TGTAAAAAAC
CCGCTACCAA
GGAGGGGAAA
CACACGACAA
CATI'ACGCT
?I'CCTATGTG
AGATAAAACG
TAGGCCTGAA
ATGGGAAAAC
CTCCAAAACC
GAAAGTGGGC
GCACCCAAGC
ACGCTTTAT
AATCATACTr
CATTCCATTA
GACACTTATG
AGAATCGCCA
GAGAGTCCT
GAACCCA'TT
GAATACCCTA
TACATCATTC
CGCTTATTCG
ATCATCGCCG
ACCAAAGACT
ATI'GAATTGA
TCCAATAACC
GATAAGATAG
CATCTTGAAG
GCCCCTATCA
AACCCAAGCC
CCTI'TGCGTT
GTGGCTTATC
AAAGAAGTGC
TGCAAJAGTAG
TTTCAGCCCT
AAACGAI'AA
ACAI'GACGG
CCAT1'AAAAA
ACACTTACCA
TAGTAAAAAC
AAAGCGTGAA
AAAGGCAGAA
TGGAG'TIT
AAAATTTCAT
TGCCCAAAGA
GTFTGGGATAA
GCAACGATAA
AAAAAGACA
GGGCGTTACC
TCACTAAAGG
CTAAA.ATAGC
TTGGGAATAT
GCTATCAGGT
GTTTGTTTTr
TGTGGTATTA
TAGTAATCAA
CGATGTGAGT
GTTTGTTITG
CCCTTATGCG
AT1TAGCCACC
CTCCTTTATC
AGTCTFI'GG
TAAAGACGGC
TGATAAAGAT
GGGGGATAAA
AATCGCTAAT
ATCCCCAGAA
ATACAAATTC
TCTCACTCGT
CAAAGAGCCT
GACTATTCAA
CACTITATGCG
CACACAAAAC
GGTGAGCGTG
AGAGCGC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1257 p a. a a. INFORMATION FOR SEQ ID NO:1286: SEQUENCE CHARACTERISTICS: LENGTH: 780 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY misc_feature LOCATION 1. .780 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1286 p p C'rIAAAAACA
ACTGGGGAT
GGTTFI'AAAA
TTTAGCGC
TTAACCCATA
AGTAAAATCG
TITGCAACGA
ATTCTAGAAA
AGCGCTTT
GTTCAAAATA
ATCAGCGCGG
TACGATAAAA
CTTATCGCTA
CTCTAAAAGG
TAGCCATGCG
ACGATICTAG
TTCTITGTGA
TCAGTIATIT
CCACAAACAA
CCGCTCAAAA
AGCCTTTAGG
TITAAAGAAGA
TCCTrGAATr
?I'GAAATCTG
TCGGGGCTFI'
CAGATTTACC
G TAITGATG
AAAGCTCTT
GATTATCGCA
AAAAACACAA
GCGCGTCCGT
TAAGCCCTIG
TTTAGCCCAA
GCATGATTTA
ACAAA'TI'I
GCGCCTGAAT
CGTGTATGAG
AAGGGATATG
CTGGATFG
G'TI'CGCTT'
TCGGGGCGTA
CTGCA'ITCAA
TTGGATAACC
ATTTTCTACT
A.ACGCGCTCA
AAGACTIGTA
AGAATCGATC
AACCCTATCT
ACTI'TAGGGG
GTTCAAAACC
ATFI'GGTTCT
ATGAAATTA
AGGAGCTATC
GAGAAAAGGG
CTAAAGACT
TTICTATCTC
ATCACGCTAA
AAGAGATTI'
ATTATTTAGG
TAAACATFT
TGGAAGAAAG
ATCTCTI'GCA
TTTTGGCGCG
TATTCATTAT
CAATGAAGAG
TGAGGAATT
TGAAGAATI'G
CCCTAGTTT
CACTCGTTTG
CCAAAGCATT
GAAAAAGGGC
ATGGGATCAA
GGGCGAATTT
AGTFI'ATCC
ATCAAAGTTT
120 180 240 300 360 420 480 540 600 660 720 780 CAACGATTTA AAAGAFFI'GA GGCAAGAAAA INFORMATION FOR SEQ ID NO:l28 7 SEQUENCE CHARACTERISTICS: LENGTH: 1038 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/ KEY miscfeature LOCATION .1038 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1287 C C
C
C
C
a.
C a GGCATGGTI'A AACACTATCT GTGCTGTTI' 'FATCTCTTC ATAAAGTGA GCTITTI'GGA yITTTTATTT TGCCGATCAC TATGACCATG AATI'GTTAGT GCGTTTGTGC CTTrAAGTTT ATCCCCACTT CTAAGAGCGC ATTAACATCA GAGCGGGTGA AAGACTGAAA ACAATCCTA GAAAGCTIA TTFGGCTCA AA TTGTATA ACGGGCATGC GAAGAATTGC ATFTGCGCAA CAAGGCACGG ATI'ATITGGG
CAAJAA~CGCC-GTTIICTCA
TrAATCCCCT TATTTGGCAT GTCCTTGGAG CGGTTGGGGT TTGATGACCT TI'TCTTCCC TTCAT TFTAA AGCGTI'AT
TTTCATGGCG
CATTGTGTI'A
TCTGGTGCAA-
TTTTTTI'GCG
GTTrTTTCTCT
GTI'AGTGAGC
TTATTACGGG
ATI'CGGGCAA
TGATAATITG,
AAAAGGCAAT
GTATTTCACT
CAAGCTCAAG
TrATrGGAAA
AGCGATCTTA
CGCCAACCCG
TTATITFTTA
CTTTATTGG
GTTTCGCAGG,
TrAATCAGTA
CTCTTTGT
GCTTGCGCTI
TTAGGGGTIT
GCGATTTAT
TTI'TTGCGTC
AAATTAGGCG
GTGCTTT
ATCAACAATC
CAAGGCGATA
TCTTICAATr
AAAGCCTTTG
GT1'TCCTTGT
CGATTCAAAA
ATGGTGCATG
GCGTTTATT
TCTIT1'TCTC
TTGCAAGCGT
ATICCTTGCC
TG3GGGCTTTC
CGCCTAAAAA
TAGCGTTT'C
AAAAAAAAGA
AT1'GGCTCGT
CTAATAAAAG
AAAACGGCGT
AAATGCGTAA
CTAATGATGC
GTAAAAACGC
TCCCT1AGC
CGAATTGGAG
TGAITI'CTAC
CTTATT1'ATI'
CTTCTTI'TTA
AACGCTCGTG
AGGAACCACT
AAGGCTI'AGC
AATGACTAAA
GCTCATC'FTA
cAAGATTGAC
GTATGTGGAT
TCTCTCTCAA
GTI'TGAATTG
GGTI'GATT
GGCTTATI'TG
TAATAAAAAT
GAGCGTGT
TTATI'TCCAT
GGATI'TGTT
GTTTIAGAAAA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1038 INFORMATION FOR SEQ ID NO:1288: SEQUENCE CHARACTERISTICS: LENGTH: 1845 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .1845 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1288
ATCTTAATT-G
ACAGAGCGTA
CAGCCCAAGA
GAGCAITTAA
TATAATGACA
GAGTTGCAAG
GGTATCACGC
TTAAGCACCG
TGCGATAAAA
GTGITI'GTGC
CGccAAGATT
AGCTATCATG
ATGGAGTFI'A
CGAAAGGTI'
GCcAAACTCA
GGTTCTACTA
AATI'GGGACG
AACGGATCAG
GAATIGCTAA
CAAAAAGGCA
AAAGACGCTG
GCCGCTAATG-
TCAGCCATI'P
AGCGAAT=F
ccTTTCCAAC
GGGGCTITGC
GCGAGCGGG;
ATCATTAAGI
GTGCT1'GA.A2
AAGGGGTGTTC
GCAAAAAAAC C TTGAGAGCTT C
AAATGCCTTT
TGCTTITCAGC
AGCATAA-GC
AAGGTTATGA
CCGTAGGGTT
'FrGTGCCAGG
CAAGCGGGCC
TTGCAATGGG
ATGTGGGCAC
TGGGGTTGCA
TAGTAGAAGA
TTGATGAAAA
ACCACACTTI'
ATITGACGC
CGGATGTGAA
AAGAGGGGCT
TGCAAAATTA
TTAGTCATAG
GAGGGCTI'AA
AAGATGAGCA
TAGAACGCTI'
GGCCTAAGTC
AGGATATGGG
SAAGTGCCTAG
T. TAAAGATGG k AGGATITTGA ATGCCTAAG C AGAGAGCTT TI
;GGTTGCGCGA
kGGTTCGCAT :CACCAACCT1 TATGCGAGC
G
3.GGAATGGAA A.AGCCATAAT
C
CTTGCTCATA
C
TATGGTGAGC
AAAGATCAAC
TTGCACTWFI"
TGTGGCCAAT
GAGCGCTAA
AAGCATCTT.
GCATTTGATC
AATCTCTAAT
CGCTTTTGAA
TTTATTTGAA
CACCAAAACC
CCTGAATACG
AATCTTAAAA
TAGGAAAGTT
TAAAAATAAA
TAACGGCATG
CTACAAGGTC
CGCGATCCAT
CGATTTGATA
AAAGAGAGGC
TGGGTI'GGGT
TGGCATGAGT
ATTCTTTAGA
'ATTI'AGAAAA
ATATI'GCGCA
LAAAGAAAGCA
.7TTAAAAATT
;TCGCTAGTG
.TGAGCTTGT
;TTI'TTGACGC
;GAGCGTTAA C
;GGATAGAAA
'.GAGAAGAGC
rATGGCACGG rCTAGCTFI'A
AGATTAGCGA
A.ACGCTCTTA
GCTATCGCTA
CTCATACCCC
GCGTGTGGGG
GACACTCATA
CCCITTTI'AG
GATATTTTAC
GGTAATTTGG
AAAGCTAGAG
GAATTAGAAA
CCAGAATTGC
GCGCTCGTI'A
TTAAGCCCTG
GAATTAGACG
ATCAACCCCT
AGGGAATTAT
'I"I'GGCATAA
ACAAATCAAA
,TACCTTCAA C ,TGTTACGGC G 6TTTTGCGAT
LCCCTGATCTC
;GGTGCCAGC
C
.rAGTAGAGAI ;GGCGIT17'7
;CTITGGGAA
kTTATAAAAA
I'TTAAAAGT
ITAATI'CTAA
rCAACCCTAA
GCGGGAAAGT
TAGGCTTAAT
GATCTI'GTGG
ITTTAGCTAA
GCTTAGCGTI'
CCATTATGGA
AAAACGACCA
GCCCTGTI'AG
GGCGGGCCGT
cGATTGTTT
GGGACTI'TGT
ACAAACTCAC
CGGATGGGCG
AGGGGGCGTT
'CTCCTAATAA
TGTTITrAGA TTACAAGCT1'
AGGTA
.GAAAAAAT
:CCTAAAAAC
~AGCATGCCA
'ATCACCGCT
;ATTAAAAAA
;ATGTGTGAT
EGTGATCGCA
L'TTGGGCGTG
MTAGCGAGC
k.GCCAAAGCG
GGAAATGCAA
rCAAATGATGcAAccccTA ccTGCCTTTA
GGCAACAGGG
GGTGATCCTC
AGTCTATCCT
TGTGATCAAA
TACAGAAACG
ATTGGTGTAT
TGAGCC-1I'TI'
GATTAA.AATC
TAAAACCCAA
GGCGGTC'ITG
CACGAATTTA
CATGAGTGGG
AAACGGGGCG
CGCCTTGAAT
AACCTI'AGAA
GAGAFI'GAAT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1800 1845
C.
AATTTAGAAA
AGCCTACTTT
GCCAATACCG CTGAAGAGGG INFORMATION FOR SEQ ID NO:1289: SEQUENCE CHARACTERISTICS: LENGTH: 642 base pairs TYPE: nucleic acid sTRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM:Heicobacter pyloni (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1 642 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:12 89
AAATATAAAG
GTCCCTGTGG
GAGGGGGGTA
GAGCTTATCG
ACTCAATI'AG
ATAAAGCTT1'
GAGATAAAAT
TGGTGGTI'GA
TTCCAATCAT
CTAAGAATGT
AGCAGGCTCA
TAGAACACGC
GCAAGATAAA
GAATATAAAA
AGAAGTAACT
GCCAAAAATG
AAATAGGGGG
AAAGAAAAAA
ATAATAGAAA
GACGCTGTGC
TTGCGATCAA
CGCGTGGGTG
GcAGAGTITTT
GACATGCCTT
TIITACAAAT
CTITAGCGCA
ACTGTGCTT
CTGGCACGAT
TGATI'AGCCC
TAATACCTGG
CAGCCCCAI'
AAGCCTGATA
AGAGGCCATA
ACTCAATCTC
GGGTCTTACG
GGTTCTAGC
120 180 240 300 360
AGCAGTGAAG
GAGTATTGCG
TTITGCCCCA
GTIGTGTGCG
GATAAGATCA
TCATGCAAGC_
GGGGCGFI'AA
CTGGGGGGAT
TGGGGGGGAG
cAGAAATTTG
TTTAGAATTG
ACTTTTAAAC
TAGcGcAGAT CTGGcTTACC
CAAGAGAGCG
GGTTATAACG
GCT'TTAACG
AACATGCGT
CCTAAAGATT
TTAGCTTI'AA
CTTTGAAATT TITCCCGGCG GCCCTTAA
AGGGGTGAAA
CTTAm'GGC
TTTAGAAAAC
TAATTCAAAA
CAAAGAGTGG
GA
420 480 540 600 642 INFORMATION FOR SEQ ID NO:12 9 0: SEQUENCE
CHARACTERISTICS:
LENGTH: 285 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
ivi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAM4E/KEY: misc..feature LOCATION .285 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:129O 4
AATACCGCTA
GTAGCTGTG
CGCTTTI'ATC
ACGCAATGCC
AAGCGAGAAA
TTGTATCGTT TTTATGGTTT GCTTATGTTI'
CTATAGGTT
GTTATATGGT ATCGTI'GCTT GGCGCGCTTA
AACGCACCCC
TTAAAGCACT ACTATTTGCT ATATTCTATC
ATGCAGTAAA
CGccccATCA AGTCCGGGAG TTITITCAT
CACGACATGC
CGCTCCCATG CGCCCTrI'CG TITCAAAACG
CGCTC
AACTAATITTT
TTGCACTAAT
TAATTTTCTA
AcAGGGATGG INFORMATION FOR SEQ ID NO:1291: Ci) SEQUENCE
CHARACTERISTICS:
LENGTH: 1080 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pyloni (ix) FEATURE: NAE/KEY: misc_feature LOCATION .1080 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:129l
AAGAAAACGC
CAGAGGTGTT
ACAA.ATGCGC
AGGTGCGAAG
GAAAGCCTA
ccccTAT1'CT
TTATGCCAAA
GTTTTGGTT
ATITTGAGAG
AACTGCAC.CC
CTGcCGATTG
AACTGAAACT
GGAAGTCGCC
CITGAGTGAT
TATTTATGGC
CTCGGATITT ACATTCTAAA TACCCAAGAC
TATTAGCCGA
CCACGACAGA
'TGAATGCGT
GCGGTGCGAT
TITACCTC
TCTTTTGCTG
TGGCTACGCC
AAAGTTACCA
TATTGGCGGC
TGAAGTCTTG
TAAATIGCAAA
CATATGGGG
GATITTGTCC
TTGAATTTAA
GCGATGCAAG
AAAGCGATT
GGCTCTITGA
TTAGAAAI'T
TMTTaGAGCG
GAAAAAGTGG
TTGAATGGGG
ACGCTCGCTG
GGGATTATCC
ACGAAAGGGC
ACTCCCGGAC
AAATGACGAA
AAAAACTGCT
AAAACGATCT
TAGGGCCAGG
AAGTCTTIGCC
TAGTGTGGCA
GTAGCGGCCT
CGAAGTTGAG
ATI'ACCCTAT
CTGATGTGGC
CACGATTCAT
GCATGGGAGC
TI'GATGGGGC
CAACCACTGG
TGTCATCAAT
AGCCCAAATA
AACCGGGCI'
CGACGAAGGT
ATACGCCCGC
GGTGTIGATT
CAAGGCTGAA
ATGCCGATI'G
TCTCACTTTG
TGATTATT
GTI'CTCGCT
GGGCATI'GCG
ACFFITTCTA
GATTTITGTCG
GGCGGGATTA
GGGGTAAGCA
GGGCATGTGA
TCTAAATTCA
TATGAAGCCC
TTAACCCCAC
ACCTI'GGACA
GGGGCTAGAG
AAAACTTCGC
TCCATCCCTG
TTAGAAAATT
TITGAAACGAC
CGCAAGCCTA
AGTGTGAAAT
CTCTTATCCA
GCTTGCCCC
ACCATGTGAG
TGTCTAAACG
AAATCATTAG
C 1711-17GCTC
GGGGGGTGTA
CCTTTAGAGC
TGCATGTCGT
ATTI'ACTGCA
ACGGCAATGT
TGCCATI'AGC
CAACGCTCCT
AAACAGCGAT
TTF1'GATGAT
CGCGGAAAGG
CAAAGGC?1'A
CGAACGCGCT
CATGCTI'GGC
TTTGTGTGGG
GCGTTTTGAA
GATGAAAAAA
TGATAGAATA
360 420 480 540 600 660 720 780 840 900 960 1020 1080 *see *0a INFORMATION FOR SEQ ID NO:1292: Wi SEQUENCE CHARACTERISTICS: LENGTH: 1020 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1020 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1292
TCCCAGGGAC
GAATTATTIGT
AAAAACTCGC
GAATI'ACAAA
ACACAAGACC
TCAGATITGG
GAAATGCATG
AATGAACTCA
TGCGAGGAAC
AAAGATTCTC
rAATATGG
TTGCTTCTAT
TTAGTGGGGG
CAAAGAAAAG
AAAAGCCGCA
GGTITI'AACA
GAAAAACTAG
TGATTTTTGA
ATCAATCCCA
GCGCCAAAAT
ATACGATAAA
CCCAACAAGA
AAAAATCAGC
AACGCA'FrGA
AACAAAGAAA
AATTCCGTGG
TAGCGATTAT
ATAGCGGCAT
TGACGCCTGT
TAGGTAAATC
AAGTGGATAA
T1'GAAAGTTA
AACTTGTIGA
GATACATCTA
TAAAAAGAAA
TITCAAACCA
CATTCAATCA
AACCACGATT
AGCTCGCTTT
GITCAGCAAA
AAGAGGTAI'
GACAAAATTG
AAGTGTAGGA
AAAACGCATC
TGATACAATA
AGTAGGTGAG
AATATGGAGT
-GAATTTACAT
TAAAAATGGT
TCAFI'ACGAA
TAATAGTATC
CAAAAATTTC
TTAGTAGAAT
AACTGCAATA
GAAAAACAGA
AATITGGATC
ATCAATCAAT
GGAAATAATG
ATI'GAAGACA
AAAAATAT1'G
AATAACCTTG
GGCTTA'1TTA
TTGCGTTAA
TITrrGATT'
CAAATTTGCG
GCAT1'GGGAA
CGCATGAAAA
CATCTACAA4
TAAAAGATTT
TIATAGCCGA
AAGCCTTAAA
TCAATCCAGG
GTI'CTACAGA
TCGAATTTAA
AATGTAAAGA
TAGAACG43CG
AACAACTI'GA
GTCTTAATCC
GTTCAATAGG
TTGCAGGAGT
CAGATTATAA
AAAAAATTGT
TGATI'GAAGA
GACAATTGGA
TATCTAACCG
TAAAGCAGGA
AGAGCTTCFI'
AGTGGTAGAA
GATGAAAGAA
TAAATTTATA
TTTTAGAAAA
AATITFGGC
GTCAAAGAA
AGAAAGAGTT
TAATTCTAAT
AGGTTTGGTG
GGGTAGCA
AA.AATCCCAA
GCAGGATGTG
ACTCAACGCC
AGAAGCCCAT
CCCCATACAA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 INFORMATION FOR SEQ ID NO:1293: SEQUENCE CHARACTERISTICS: LENGTH: 657 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .657 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:l293
AGTGCCTTAT
TTTTTCAAAC
GCTI'IAGAAG
ATTTTAGCGA
AAAGCGACGA
ATTTCGCATT
GAATTGTI'AG
ATCATFI'TAG
GGGCATITI'G
TAITTGCAAC
CATGCGAGCG
GGCACAAAGA
CGCATGAGAT
AGATGCAAAA
TCAAGCGGCA
TTCAATCCAA
TAGCTACTTC
AAACTTGCAT
GITGCACGCA
CCCT1TCCAAC
AAAAATACGC
GCGATGTGAT
CCCCACCACG
TGAATTATTG
GTATTCTAAA
AGTGGAAGAT
CGCCTATGAC
TCTITITGTG
GCATTATI'AT
TTTTCCCTTA
GCCCCCCCTA
CCTI'AAAAAC
CTGGCTAGAA
ATCAAGCAAT
AT1'GTGGCAT
ATCCCTATTG
AAAAACGCCC
AACGCCCTGA
CCTTTGATI'G
TTCACTCCCT
ATCGCTCAAA
CTCATCCATT
AATGCATGCA
AGACAAGCTA
F1'GGCTI'AGA
GCAACACCGC
TGGGCGTGAT
CTATTTI'AGT
AACAACAAGG
AAGAAAGTAT
TAGAGA TF1
AAATTGAGGG
CGGGCGATGC
CATTCCCTAA
AAGAATGGCT
GGCT1'TGGAT
GAGCGCTCTG
TGAGCCAAGC
GCTAGGGACA
CTATTI'GAAC
TFI'AGAGGGC
ACCCGAAGTG
CTATTTCATG
TATTGTAGAA
AGTGGAATTT
CAAATTG
C.
C
C C C.
C**C
C.
C
C
C C. C
CC..
C C INFORMATION FOR SEQ ID NO:1294: SEQUENCE CHARACTERISTICS: LENGTH: 327 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .327 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1294 0 ,C 00 0 GGTATrAAAC
GCAGGATI'CT
TTTGCAGGAA
ACTA.ATCCGC
AGCGTGCCTA
CAAAGCATGG
TAGGGGGTAT
TATCGCAAGT
TAGTAGCGGG
AAATGACCC
TGAAAGCCGC
CTGTGGGAAC
TAACATGGCA
CTCCTCAATC
CGCTATGACA
TATCATGACC
TAACCAACAA
AATATCT
GGCACACAAG
ATCTCAAGCA
GCAGCGATTA
CAATACAATC
TACAGCCAAT
CTATATATGA
CA.AGTGGTGT
TTCCTATI'GT
AAAGCATCGC
TGTATCAAGG
ATCATCTTCT
CGCAGGGCCA
TGTGGGATT
TGAAGCTGTA
TITTTAACGAT
INFORMATION FOR SEQ ID NO:1295: SEQUENCE CHARACTERISTICS: LENGTH: 366 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .366 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:129S
TTCAATT'G
GTTGTAGTAA
GCAACAGGCG
GTAGGTGGTI
ATCAAAAGAG
GCAGGTGGCA.
GCTAGC
AAAGGAA.ACG
CTTTAGGGCT
TI'ACTGAGAC
GCGCITI'AGG
GTCAGGCGAC
TTATCTATTT
CATGAAATr
AGTGGTAACA
TAAAAGTTTG
GGTCAAAGGC
TG'TT11.GCT
GAGCACTAAG
'rTTACAAGAA TCACTGACAG ACCAATCCTT TAATGGCGGT GTATTCAGA TCATTTCTGT ATAGCAGATA TTI'GGAAAAT TACGCGCAAC CCATAGCTAT TTTGGCTTCA ATATI'GGCGA
CTACAAGAAA
CACCAGTCCT
TCTAGCGATC
CTCTGATGAC
GTTAGCGGTG
GAGTGGAGGA
120 180 240 300 360 366 '00VO *0* 0000 *we, be *5* INFORMATION FOR SEQ ID NO:1296: SEQUENCE CHARACTERISTICS: LENGTH: 2973 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .2973 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1296
AGCGGTATAT
AAGCTAGTTA
GCAGACATGC
'FrGTTrGGTT GTA TTATCTG GTGCTrGTAG
ATGAAATTTA
TFI'TCCATGA
GACAGGCTI'G
GATGGGGTGA
GA'TI'TTAA
TTrAGGAATT
G'ITATTGATG
TATAATGAGA
CAAGATTTAT
AATTTTGAAG,
CTATAAAGAG
TAGAGCAAGA
AAAAGGGTGT
TCCCTGAAAC
TTATTCTII
CTCTI'GGATT
AAAAACCTTr
AGCCTAGTAA
TGAGCGCTGC
TCCTTACTAA
CCACTTCCAA
TTGTTACCCC
AAACCAATAG
AGCAAAAGAG
TAGACACTCT
AGTTTCAAAG
AGGGGTGTI'
GGTTCAAAAG
CAATCCCTT
TTTTATI'TAT
TCAAGCCTAT
CAAGAAAGAT
ITTGITTAAG
AGAAATGGCT
AAACTCCTAT
CAACTATTCT
AAAAGATCTC
TGAATTCAAA
GGAT1'ATGGT
AGAAAGTTI'
CAATGAACCC
GATTATTAGA
GTGGCAAGCA
CGGCAGTF1'C TrTTAAAGTCT
TCTTCTATAT
GAACCTGTF1'
TACAGGCT'TT
GGCGTGAAAA
AATGACATCC
CTAGCGAATA
C?T1'AGGCA
ATAGAGTTAC
TTATITTC
CTTATTT
TATGATATTA
GTrATGAATA GCCAAGCT1'G
AACAAGCTGA
AAAAAATAGA
TGTTTGATGG
TrATATTGTT
TGATTGTAGC
ATCAAAGAAT
ACAAAGCGTT
ACTTAAATCC
ACTATGAATG
CAATCAAATT
ACGCTI'CTAT
ACAcTGTrAA
CTAATGA'ITT
GTTTTTATCT
AAAAGCATFI'
AAAACI'CAA
CGAACAAAAA
AGAACT1'AAA
GGGGAATAGG
TGTAACAATT
GATIGTTAI'
GGAGCGAGCG
CATGAGCATT
AAACAGAGAA
TTITI'TAGAT
GGGGGGCATT
TTATAGCGTI'
AAAGAAAATC
CATGCGAGCC
CACCATAGAG
TGCAGACAAT
AGATAGGATA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 GAGCTCATAG AAGAGCTACT GATGGCA'FTA TTTACTCCAA GCCCCTT'ITA T1'TGCAACAG AAAGAAGTTT ATFI=TGCCAA TA'FITTAGCG CTATrGAGAT AAAATCAACG CTCTAGACAG CAAG TTrTAA AGGACAAACT AAAGAGCAAG GCATGAC TTI' CTAGGCAGWI' ATGGTAAITC AGCGTI'AAGG AATGCGTCTC TI'CTCTATGG AAAATI'ACTT TTTGATGTAA CTTCTAACAA GGCAAAGAAG ACAATAACGC
TCGCCTTTT
ACTI'TGATAC
GCTATGGGGC
ACTATGG'TT
GAGTATGTCA
TGTGTGCAAA
GAGCTTGTGA
TCITI'TAGCC
GATATGAACC
GATCCTAATG
CAATGGCTIT
GTI'GATGGGT
TICGCTCGTA
TGGAAATATT
AGGAAALAGAA
CCTATTGCTG
GGTAATCTT
ACTAAGGGGC
AGT'T1'AATT
TI'GTCAAAG
TTGAGGCAAA
ATTTGAACTT
TI'GGCTCAAC
AATI'TGCCTA
ATATGGATAA
AGAFI'GAGCT
AAACAAATGC
AAAACTTAGC
TAGCAGA?1'C
TAGATI'ATCC
GGCTI'GTCGC
TGACAATAA
CAAGTT'CT'
TCCAAGAAGC
TAGGCGATCC
ACGCTATIGT
ATACGAT'AG
CTGATTACCA
TGGATAGGAA
TGAGAGGCAT
AAATTGACAA
TGTATCAACA
GAGTAAATAC
ACAATGCGAA
AAAAGACITG
TAAGCATGGA
CAGTGAATAC
CGAATTTATC
AGCTI'TCACC
GGG'rrGCTTG
TI'TAGTGCTG
TAGTCI'AAC
TFI'TGCCAAA
TFFI'GCTGAT
TTGGGGCAAT
CCACATGCCC
CGGTTCAGGT
TAA'TITCCT
AGATI'ATGGC
AGGGACAGAT
AACAATGGAG
AACTAAAAGC
TAATACGCTT
TATCACTCAA
GCGATI'AGCG
AGCAACAGAT
AGACAATAAT
AATGGATGGG
AAAGGTCGCT
TAGACTTGCG,
AGAACAATGC
AAGATTAGCC
AATCCTCTAC
TCCTAAAGAA
GATTATCCAA
AATAAAGGAG
CACCCCACTA
TTTrACAAT'
TATCTCAAGG
AAAATCTI'AA
GCCCCTAAAT
TTTATGCATG
TCTAGAAGGA
AGCGAATTAG
TTTGCTGATA
GCTAAAGGTT
CATTGCTC'T
?1'CATAGCGA
AGCGTGATGA
ACTGATITTTG
AAGACAGTGT
GCTAATATCA
GCTI'ATGGGA
ACAGGATI'AA
CAAAAACAAA
GATGAAAAAG
GCAGCGGCAG
CTTATTAATG
CCTTI'TGCA
CGCTI'AGAT
GACGTI'TCGC
CGTAGATTTG
TATTTTGTGA
ACTCAAAGCA
CCTACAAAGA
AATGTI'ACAG
AAACAGGATG
TATTTGAAAA
AACCATAGTA
TAT
GATTAAAAGA
?I'CTI'GTGGG
AAAAAATGCA
ATGACGATT
CACAGAGCGA
CTI'ATTCGCC
T1'ATTATTAG
TGGGTAATGG
GCTTTGAAAA
TITTTAGCCAA
TI'ATCACGCT
TGAGAGCGAT
CGTrAAAAAG
GTI'CAGCT'C
TTATGTCCAT
GCAAAGACAA
ATAFI'GTrGC
ATCCTTTTGC
CAGCTATTTC
ATGAAAATGG
TAACCAACCT
CTITCGGGAA
AATCAACCAA
TITCAAAAAC
CTrFI'ATTTG
TCTTAGATAT
GAGACATGCT
TCACTGATCT
TITI'TTTGAG
AAAA.AGAATT
GAAGCCCTAG
TI'TTATCCAC
TCATAGATAA
ATACACTAAA
AATGAATGAA
TGGTGGGGTG
GAGTGAAAAA
TTTGTTTGAT
TAAAAACTCA
TGGAGGCTCC
TGATATTACG
AATGAAACAA
CGCAGCGACT
TCCTTTTATT
GAGTTTTGAT
CGAGATCAAT
AGCAGGACAC
GACTCTAAAC
GCAAAAGCTC
AATGGGTGGG
TTGGGCAGCT
TGTTGTCAAA
CAACAGCATC
TATCACAGGA
AGACCACAAT
TGGTGAATFI'
GATI'ATTGGC
TTTI'TACCT'
TGATGAAGCG
AAAAACTGCA
TTrGGCTGC
AAACGATGGG
TGAAATCATC
CGTI'ATCGCT
AGATACTGTA
ATATCAGGCC
1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1800 1860 1920 1980 2040 2100 2160 2220 2280 2340 2400 2460 2520 2580 2640 2700 2760 2820 2880 2940 2973 es..
0* S 6S S SO *S S S
S.
.555 5 5@5e *5
S
OS. INFORMATION FOR SEQ ID NO:1297: SEQUENCE CHARACTERISTICS: LENGTH: 3549 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geriomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NME/KEY: misc-feature LOCATION .3549 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1297
TTITACTAG
GCCATI'AACC
CTTCAAGTG
CCAATCGT'G
AGGGAGGAAT
AGCTI'TATCA
CATTAATGAT
AACAACCACA
CTI'TTATTAA
ATAAGAATGA
TCGCTAATAA
GTAAGAGCAA
ACCAAATTTA
AACCGAAGCG
AGTI'GATAAT
TAGGGATAAT
AGCGATCAAA
TGATTTAATC
GATATAGAAG
GCTTTTAACC
GTI'GTCGCTI'
AGGCAAGCTT
AATCCTACCA
GACAAAGACA
GAGAAACAAT
CGCAGCAA T CATF1'GATCC
'ITGAGAAAAT
AAAAGAATCA
ATCTCATI'A
GACTAACGAA
TATCAATAAT
TAATCAAAAA
CTCGCAGCTA
GTATTTCA
TACAGGTI'CT
TCCATAAAGA GCTI'TCAGAA
TCCCATCAAA
ATCATACAAC
CAAGCTTTTG
GTGTTTGATG
GATCCTACTG
TCTTCCGATC
GCCACTACCA
AGGGGTAATr
GCTCACAT'G
TCTGTGTTAA
AACAATGGTG
CGAGGCGACA
ATAGCAGGTG
CTCACAGGCT
GAATTTCTI'G
TTICCAAAATG
AATGATCACA
TTIGGTAATG
TTAGATAGGG
GTTGATrATT
GCTACGAATG
CCTAAT1'TAA
ATCGCTAAAG
AACAAAGAAT
ACAGGCAACT
CGAGAGCCTT
AAAATGGAAG
AAAGAGGCTA
AGGGAATTGT
TTTGATGAAT
GCCCTTAA.AG
AACCTTAATG
ACCCAAGCAA
ACGGATAAG
AGTGGGGTAG
CAAGCTCAAA
AAGAATGGTG
CTTTCTAAAA
AACAATAACA
AAGGTAAAAG
CAAGCAGCGA
CTITCAGCTA
TTGAAAAGGC
TTGACTCAGA
GACAACCTAG
CTATATGTI'G
GCTACTAACA
GCGACCGGCA
GTTGCGCATA
AAGAATATGA
AAAGACATTA
AGCTIGATGA
CAAAAATCT
ACGATCCGTC
CCCCTATCTC
CAGGAATI'AT
AATCTTTGAA
GTGGGGATI'G
TCAAAGAAAC
CCACTGACAT
TTTCTAAATT
ATCCTAATI'A
TGGGGAGTCA
GTCCTGAAGC
ATGTGGCTAC
GTGAGAAAGG
CACAACGAGC
CACAAAATAA
AGATTGAAGA
'FIGC 1-171T
GGGAATTGAG
AGGCAAAAAC
CTAATFI'CAA
GCGTF1'CCCA
ATAATCTCGC
GATTGTCCCC
TGG?1'GGAAA
ATGACGAGGT
TGGAGAAAGA
CAAAATCTCA
ATAGGGATC
CTGATAAACT
TCAAAAATGG
GCTCGGTGAA
CAGCTTl'GAA
AAAGCCACCT
TTGATAATCT
AGCAAGCGT
AAAATGAAGA
TAAACGGAAC
ACTTTTrCGGA
ATAATGGACT
C AAAAATTGA GCTCrCcTrr
ACCATGAACC
ATGATAAAGT
AAATTGACAA
ATCAAATGAT
AAAGTGCAAA
GCCACACACG
*TGCTAACGCA
*ATGTGGGAAG
*AAGATI'ATTC
AGTCTGGCTI
*AAGCAAGTG~I
ATTGGGACT
TAAXATCAAC
TGATGATAAA
CATAGGAAAC
AGAGAGGCAA
GCTTGATATT
GCTCAATCAA
ACAAAGCTTA
CACTCTTGGC
CAAGT1'CAAC
TAATGGCATA
TAGGCATGAT
ACTCATTAAT
GATTAACAAC
ATTGAGTCAA
TGCTAAATrA TrTrCAAAAA
TTCTAAAAA
CTACACTCTC
CACTCTTCAA
ATACACCAAC
T1'AGAAGCA
TATCACTAGT
ACAAGAAGCT
AGC?1'TAAAC
GAAACAAGCT
TGTAGCGAAA
AGCTAACAOC
AAGAGCAATC
TGAAAATATC
CAAAAATAAG
AGATTAGGT
TGAATTCAAA
TGAAAATTCC
CAATCAAGCG
AGCCGATCTC
TTTCAATACT
CCTAGTCGGT
CATCAAGAAA
CGAAAACAGC
CCGACTCGAT
GAAAAGGCCX
CXTTTACGC7
TGATGATCTC
TCTCAACCAG
AGACAAGCTC
AAAAGTGCC7I
CATTAATAGC
AAAAAATTC7
TGCTCCTG
TGATTCGTI'C
TGTGCAATT7
GGAACATGG;
CAGCGTTACC
ACCCAAAAAA
GAGAAAGCGG
CAAATCCGAT
GAAGCAGAAA
TTI'TTATCAT
GAACCAGTTC
CCGCCTGAAG
GATATGAACA
CAATTATTGA
GAACCTGAAA
TGGAACGCCA
GTGCATATGA
CCTAGTITI'T
GAAGAGATCC
GACAACTI'CA
GACTCTAAGG
GACAAAAAAC
AAAGATTATG
GGTAGCCTAA
GCCTCCAAGA
GGCTTTAGCA
GTCGTAAGGC
AATAAGCTTG
TTCAATAAAG
CAGAAAGATC
AATTTGGAGA
CAAAGATG
GCFI'ACGCTC
AACAAGGATI'
GATTTCAGCA
ATCAATCCAG
AATGGCAAAA
ATI'AAAGATG
GTATCAGTGG
AAAAATTTCT
GGAAAAAATT
AATGGGTI'AT
GAGTTGAAT'C
ACAGAACCCA
CAAATA.GCAA
GATAAAGTTG
ACGATTGATG
AGTAAGGTAG
GCGGTATCAG
AAAGATTCTA
ACTAGTFI'GT
AATGTCAAAA
GAGTGGCTCA
TCAGCGTATG
AAGTITI!CCA
TTAACCAATA
GTCAAAAATA
AAATTTTTAT
TCCGAGGTT
AGTITTFTGAG
CGGATCAAAA
AAAATGGAGA
T-rGTGI'TAA
CTCATGTCCA
CTAGGGATI'
TGTTAGATGT
TCCACAATAA
AAGTTTCATT
CCGTTGGTTA
AA.AATGGCAG
ATCTCTACAA
AAAACAAAGT
GCAAGAAAGA
C'FIATITAGA
ATTTAGCT
GGAAAAAAGC
AACATGATGG
GTCCTGATAA
AGGTAGCTGT
AGGATII'AGA
TCAAAGA'TTT
CTGTAGCTGA
TTGAAAAATC
GCAAAAGCGG
AGATTTF1'GC
AGAATCTTAA
TGAAAGACT
AGGCAGAAGA
AATGGATITC
ATA7AGGATT
TGATCATCAA
CTAAAGCAAC
CAAAGGAGCA
CTGCACTATA
CTAAAGCAGA
CAAAACTTGG
TTTIATACTCA
GTGGTTIGGG
ATGATCTCAG
ATCTCGGCGG
GGCTTTCAAG
AAGCTAAAGC
CAAAAAAGAA
CAGCGAAAT
ATGGAACAAT
AGCTCGTGAA
ATAAAATTGG
CCAGGTI'GAG
TATTITCTAT
CTAATACAA
GAA'FTGGGTG
TATGGAAAAT
GTCTGCCAAA
ATI'CATGGGC
GCCTP.ATGGA
CAAAAAACAA
ACCAGATGTA
GCTrGATGAA
TGAGGGAGTC
CGCTCTGTCT
GTTGTATGGA
TAAAAACCAA
TGGGTTAGTC
AGAAGACCAA
GGATT1'CATG
GAAAGAAAAA
CGCCCTAGCG
AGTTGCTGAG
AGATAAAGCT
CGTGATGTT
GGGTGTGGGT
CTTITAArrTG
GGATAAACTA
TI'TGAGCAGC
AGCTAAAAAC
TCTAAAGAAA
CAACAAAAAT
GTTGATCAAT
AGGCATCAAX
TAGTAAATCT
AACACTAAA
AAAAGTTGAA
CAGCAAGGTA
TCAAAAGATA
GGGTGATT1C
ATTGGCTCAA
CCAATCCGTT
AGCCACAACT
AAATI'TCAAT
AGTTGCTAAA
TGATGTAGGG
TAAGGTAGGG
ACCTTITCCCT
GGAGCAAAA
AAGTCATTTT
TGTTGTGAAT
CGACA7ATTAC
CAATGAAAAA
TGATAAGATA
ATTCAACCAA
CAATGCCGTA
GGGATCTTAC
AGGTGGTTTC
420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1800 1860 1920 1980 2040 2100 2160 2220 2280 2340 2400 2460 2520 2580 2640 2700 2760 2820 2880 2940 3000 3060 3120 3180 3240 3300 3360 3420 3480 3540 3549
S.
S
*5
S
*5
S**S
*5*S
S.
S
INFORMATION FOR SEQ ID NO:1298: SEQUENCE CHARACTERISTICS: (A)*LENGTH: 672 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE-TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .672 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1298 GCACTAAGT' TGGCTTCAAT AATAATAACA ATAAAAAACT ITCAGTTCGT ATGGGTCAGC GAAAAAAACA CTCCCAATGG ACTATCAAAA ATITGAAAGA AAAGATGAAG TITFI'GACTT AAGCAITACG ATCCAGTTAT AATGTAGAAT TACAGATCAA.
ACGACCAACA AACAACGCTG GATGATAAGC TATATAATGT TGAAACACA ITAGCACCAT GCGGTATATC TA
AI'TGGCGAGA
GAGAGGCTT
AAATGACGAT
GCTTGTTI'AT
CAAGAAAGTA
CGTGArI'GTC
TGAAAAAATC
TCCTGAAGTG
CTTTCTATCA
TTI'ATTGGCC
AGAGTCTCTC
GTGGAGGAGC
TTITTGAAAG
AAAGAAGCCA
ACGAATFI'AG
ACTI'TCAAAG
AATAGAGTCC
TTTGATGAAA
AAAGACT~vTT
TTGCACGGAG
GTATTCAATT
AAAAAAATCT
TAGCTAAATT
TTCTCTTAAG
AAAAAGAAGC
ATTTTGATAG
AAGTCAATCC
TTAAAAAAAT
AGGGTAAAGA
TTACTTTICAA
AAACAAGAGA.
CTTATGATCC
TTTATACGAT
GATCAACAAT
TCTCGTIGTT
GCTAGAAAAA
T2TTTAAAGCG
CGATATTATC
AAAGGATT1'G
AATGGGATTG
AAGCATCAGC
AA'FIT1ATGC
TAATGATCTT
TACATGTGAA
INFORMATION FOR SEQ ID NO:1299: Wi SEQUENCE CHARACTERISTICS: LENGTH: 462 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .462 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1299
AATAATGCTA
AAATI'ACTAT
CAAAACACGG
GTTTCTAGAG
ATACTCAATG
AGTTTCCAAC
ATGAGCCAAA
ACATACTCAG
AAAATAAGAA
TITGC'1TGGTG
ATATAAAAGA
ATCAGCTAAA
ACTATAATGA
CTAATGATAA
TGATGAGCAA
ATI'CATCGTT
TAAAGGAGTC
TCiFTATcATT
TATTAGTCCT
AATAGAGATC
TAAGAATGTT
TCTAGGTATC
TTACGGTCCA
TTTACCACCG
AAAAGTATGA
GGCATGTTTA
GAAGATATGG
CCTAAAGAAA
AATATCAAGT
AATGCGATGT
AACAATTCI'
ATCTTAGGGT
AAACGAACTI'
ACGCTCCGCT
CGCTAAATAG
CCCTAGAGCA
TTGACGACAT
GGGGCATTCA
TCATGTATGG
AT
TTATMAAATT
TAACGCTGAC
CGTGGGGCTT
AAAAGTGGCC
AAGTTTAGGG
AAATCTTCTC
CTATGCGCCA
INFORMATION FOR SEQ ID NO:1300: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 1554 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1554 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1300
CCTI'TGG'ITA.
ATTTGATT
AAGTATTTAG
GGFI'GGGGGC
AAGATI'CTC
TCTATCCCTG
AGCGCGCTAG
CTTGGTGCTA.
GATGGCG=tT
AAGCATTTTG
CCCAAAACCA
AAATI'AGACA
ATGAAAAAAT
CGCTCTI'TAT
TACCATAAAA
GTTCAAGAGC
AGCTATATCG
AACAACTCCC
GTCCTAAAA.C
AAAGACGAAT
GAAAAAACCC
AAAAGCGTGG
GAGAGCGCGA
ATAGGTAATA
GCAGAAGAAA
AAAGCGTTGA
AAATAAGGTT
TTTAAAAGG
TGGTTACGAT
AATACAGCT
AAGAAGAATT
ATTTTAAAGA
AITCGCTCAT
CCAAGCAAGA
TTGATGAAGA
AAGAAAGCGT
CCACCCCTr
TTCTTATCCT
ATATGAAAA
ATITTTGACGC
ACAAGGTGTC
AAGTCAAGCA
CTCTAAAAAA
CCTATACTGC
CAGAGCCTT
TGCAAAATT
TTIATGGCGTT
GTTATGTAAG
AGTTIATCAA.
AAGTGGTGCT
ACCAATACAT
TAGAAGAATT
ATTTGATTT
GATI'AGAGTT
ATGGATAAGC
TI'CTTTAGAT
AGCCCAAGAA
ACTCACCGAA
CAATCAAGCT
AGTGGCCAAA
ATI'GTATAAA
TGAAAGGCTI'
GGAGCAATCC
AAPLTCCTAAT
CCATAGAAAG
TAGTTTAGAA
TTATTTGGAC
TGAI'ITAAAC
GGGGAACGCA
TGAAATCACG
TAAAGATGGT
TGATGAAGCC
GCAAACTTrrA
CCCTAA'TTT
CACCCTTT
TI'ATCAAATC
GCAGCGTTTA
GAAAAAACGC
ACTATAAGGT
CTI'ATGATTG
ACGATCGC'TT
AGCGATAGCG
TACCGCCGCC
GATCAAATCA
TTATTGAGGA
GAGATCAGAA.
AATATCTrAA
TTAATCCTTC
AGTCTATCGC
GATGTTAAAA
TGI'TAAACC
AATGGATGCA
'ITATTGCCGC
CTGCCAAAGT
TI'AAAGACGC
AAGCCATGCA
ATTICGCTIT
AAACGAACGT
AACAAAGCCA
AAAAAATCAG
TITGGGCAAA.
TCTCTCTCAA
0* GATTFIAAAA AGCCCACAAG AAAACTGATT TGAAAGAGTT AAAGAGGGGA AAF1'ACAGGA
TGAATITCAC
AAATCATAGA
CGGAATGATA
GGGACAGATT
CTATGCTGAG
TTTAGAAAAA.
AGATTI'AGGG
TTI'TCAAAAA
TI'ACCGCCCC
CGCTCTATTC
ATTGCAAGAC
TGAAGAAGAG
CTTTAAAACA
GGAGGAATAC
TITTAAAAGC
AGCCTI'AAGG
TITTGAAAAA
GCCCCTTGAA
CTCTCAAAT1'
TCTGACTCAA
TTTAAAGGG
TAACCAAGAA
GTI'TGTAACC
CCCCTAGT
TTTIGAT
TCAA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1554
ATGCAAAAGG
CAAAACTACA.
CAAAAACTCA
TTIATCGTGG
AAAAGCGCTC
GCTAAAGAA
GGAGGCACTA
AACCdCCAGG
ACAGAGCAAA
GTCAATAACA
TATAAGATAG
CGAATGAAAA.
CCACGCAAGA
CCGCTCTCAA
TGCAGCTI'GT
TI'AAAACCCG
AGCTTAAGGA
TCAGTGAACT
AAAAAAAAGG
ATTTCAATCA
CTAAAACGGA
TCAAATACAT
INFORMATION FOR SEQ ID NO:1301: SEQUENCE CHARACTERISTICS: LENGTH: 471 base pairs TYPE: nucleic acid STRANDEDNfESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE:, NAME/KEY: misc_feature LOCATION .471 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1301
AAAGGTAAGC
TCAAACTCTI'
TTGGGCIr
GTGTTAGCGT
CTTATAAAT
GCTGCCTI'AG,
TI'TCTAGCCT
TCATACATGT
TAGGCCTAT'
GTI'GTAAGGC
TTrcTCCrrT117
TAGTCATAGG
CAGGGCTATC
TGTCTTI'CTC
TTTCTTTTTG
CCCCAAACTG
TTACTATT
CTGTTGTI'GC
TGAAGAAGTC
GTCTAGATCT
AGTATGGCTT
AGCTI'GTTCT
GCTCACCCTA
CTCATGCAAA
TCAGACTTAC
TITCTTI'CT
TCTGGCTCTT
GGGTTAGAAG
TCAAGCTCCC
TCCATTTT
ACCATGCTGA
GCCCCAAAAT
TAGAGTCGCT
TTGAAAGGCG,
TI'GAAGCTGT
AAFICTGTGT
CACTGCTCCT
TAAGAACGAT
TCAAGTATIT
CTGAGCCTT
AATTTGCTT
TCGT7ITI'17C
TTCTI'TGAGC
CTTAGAAGAG
CTFF1'GGAAT
TGCATCCACT
GATATACCCA.
G
120 180 240 300 360 420 471 INFORMATION FOR SEQ ID NO:1302: SEQUENCE CHARACTERISTICS: LENGTH: 618 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION 618 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1302 GGGCTTTTGA AGCCTTTAC TTAAAGCCTT1 ATGAAAAAC TTAATI=CA GCGTGTTGC GCTATGCCTA AAGCTAAGC GAGTCCTTAA AAGATCAAC ITAGCCAGAA GCTTGTTGC TTAGATTTAA AAAACCAAC GAATTGAGCG TTTTAGTCJ GTGGTCATGC TCAAAGATI TCACACAA'IT TAAGCGCG( CTI'GTGGTGT ATGCGTTG ,A AGAAACCGAA ATCAAGGCGT GTAACAAAGA GCTTATATCC' CCCAAGTGGA
C
A
A
C
:T
CAAATI'GATT
rTTTGTCTI'A
CATTAAAGAA
CATITAACGAT
AAGAACGCCC
CCTTTITTT
TATCCATGAT
AAAACTTTT
TTATGACACG
ATGGGGAAAG
GCCACGAGCG
TTGTCCGGCG
TTATTGTI'AC
GATGCGATTA
CCCAATTTGG
T1'GCAAGCTT
CCCCTAGAAG
CGACGCATIT
T1TTTAGAGCG
GTCAAAGGCA
TGGATGAGCC
AAGATGAGAT
TTGCCAGGCA
CCACGCCAAT
CGATCTGGCA
TATTTTACCC
ATATTATGCG
GAATCTG C CT1'GGATTTA
GATGGTACTT
TACGAGTGCG
GAAAAAACGA
CTCCACGCAT
CGCTATGACT
TGATGATAAG
S
INFORMATION FOR SEQ ID NO:1303: i)SEQUENCE CHARACTERISTICS: LENGTH: 339 base pairs TYPE: nucleic acid STRANDEDNESS: double CD) TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .339 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:l303
AAAAAAAAAA
AAAGAAGCCG
GTAGGGGGGC
AAGAAAAATT
GCCCCTITG
TTTCCAAT
AAAACGATGA
TGCAACAATT
GTI'ATAGCT'
TTAACGCCCT
AAAGCAATT
CCAAAGGCCA
AAAGCATATC
TGGCA'FrGAC
GTGGTCGGCT
TITGAAAGGG
ACCCGTTTTA
CI'GATCGCC
GCTAAGCACT
GAGCATAACA
ATTGGCTTAT
GCGTATITAA.
ATGGGATTAA
CCTTACGAC
TI'GTAGCGGT
TGTTTGGATT
CCATI'ATGAT
TGGATGAGCA
TCGGCGTGTG
ATCCACCAAT
TI'GGGATITTT
CTATTTAGGG
TTTIAGAAAC
GTATATCAAT
INFORMATION FOR SEQ ID NO:1304: SEQUENCE CHARACTERISTICS: LENGTH: 468 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANlTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .468 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1304
CACAACAAGA
TACTACACCC
TCTATGGGGA
CCTTGCGCGT
CGAAAGGGGA
ATCGCCTTTG
CCGCAAAACG
CCACGCACCC
CACGAATGAA
CAAGCGTTTT
GCTFI'GATGA
TAGTGATTTC
TTTTAATGAA
ATAAAACCGG
GGCATTCTAA
GATCGCTTTA
AAGAGCGAAA CGGAGGAAAT ATICATCGCC TTAATGATCG GTGGA'ITTAT AGGGGGCTTG TGTGCCTT'A GGGTATITI'G AGGACTOCAT GTTTTAGAGG CACTTTGACT AAAGGCGTIT AGAAGAAGTT TGCATTACGC TCCATTCAAA AAGCATGCGA
TTATCACTAA
CTGTATTACC
TGGCTTTAAT
GAGGCGTGGG
TGCTTACCCA
TI'AAAGTGGT
TTCTI'GCTCG
AGAAATGT
ATITTCACGC
GCCCTTGTTT
GGTGAGCTGT
AGCGGCGAGC
AACTAAAAGC
GGATATI'GTG
CAGCTTTAT
120 180 240 300 3'60 420 468 INFORMATION FOR SEQ ID NO:1305: SEQUENCE CHARACTERISTICS: LENGTH: 297 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEN: misc-feature LOCATION .297 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1305
CGCTCCACTC
AAGCAAAGCG
GCGATCGCTA
AAGGCGGT
GGCGATGTGG
TAGCGAGCGC
CGGACATTGT
AAAAAACTAA
TTATCGTGCT
GGGTIACGCT
TGATGTGGGG
GATCACTAAT
AAGCAI'ATT
AGGGCTTATG
TTTAGACTTA
ATTIGGCATGG
GACTCCI'AA
TGGCAAAATA
GGGGTAGCGA
GCCAATTCCA
GGAA)AGGATC
GCTCTTTAGT
TCTTGr1'CGC
GCTTGTGGGA
TGCGCACGAT
AGAATTGAGC
CAAAGTTI'A
TF1'GGGGATT
AGCGGTCTT
GAGGGCT
INFORMATION FOR SEQ ID NO:1306: SEQUENCE CHARACTERISTICS: LENGTH: 1083 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO, (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .1083 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1306
CACCAATCTT
GGTTTTGAAA
ATTCAAGGGC
AGCCGTTTAG
ACTTI'CACCA
CAAGCCCT'A
CAACACATGA
AAAACGCTCT
AACGGCATGA
CAAAACGCGC
AAGATTTTAC
ATGGTAGATG
ITCACGCACC
GGGGCTGATA
AAATI'AGAGA
AGCCATAACC
GTGATI'TGTA
CAAAGCCCTI'
TGG
TI'AAAAGAGC
AhAGCATT C'TrATI'GAT
CGTATTTGAT
ATAAAGCGAG
TCCCCCCCTT
ATCTTTTAA
GCAAACAGCT
TGGATTTGAG
TCAAAAAAGA
AAGATAATGA.
AGTATCAAGA
ATAATITGTG
TITCTAACAT
CCAACTACCG
AACACCGCCA
AAGAATACCC
TTAAAGAAGG
GITTGAACCA
AGACAATI'TG
TTTAGCGGGA
TGGCGCTTGT
TAAAGA.AATG
GCTrGCACT
AAGGGCGTGC
AGAAGAAAAG
AACGGAGCGC
GCTGGGAGCG
GGCGTGCCTA
CAAGAAAGGG
TTCCATCGTT
GATrTI'CGG CAAAATTI'CA AATTTCAGGG
CGTGCAAGAT
CAATTTAGTG
AAAACTCGCC
CACGAACGCC
CGTGGTGGGC
TAAATTTT
CTCTAGCGCT
CATTAAAACG
CACGCAAAAA
GCGAGAATT
AGCGAATGTT
GATITrTGACG
AAAGAGACCA
CTGCAACTGG
GATGACGATC
TCCAACAI'I
GAAATCTTAG
CTICAAAGT'
GAAGAGAGCC
AGAAAATATC
GGCGAGTIT
AAAAAATTGC
GTAAGACTAA
GCGAAAACAC
CTTTGAAAIT
TIGGTTTGCT
TGCTAGATAG
CGAGCAT1'TC
ACAAAGCGTA
ATT1'GCTITG
GCGAACGCTA
AATTTTTAAA
AGAGCATrA T1'AAAGGGGC
CGTGCGCTAA
TCAAAGGT'C
TGGATIGTGGC
GCTATI'TTGT
TAGAATAATG
CGCATGCCAC
GACITTTAACG
TTTAACGCTC
GTTGAAAAAC
GTTTTTAAGG
CGATGAAGTG
TCAAATCAAA
TGAGCTTTAT
'TTTGAGCCTT
CCATTACAT
ACAA"ITGAGT
TGGGTTTAGG
TAAAATAGTG
TI'CCCTGATC
GCACAAAAC
TATCAGATT
ATCGTI'TAAA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1083 INFORMATION FOR SEQ ID NO:1307: Wi SEQUENCE CHARACTERISTICS: LENGTH: 2526 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAM'E/KEY: misc feature LOCATION .2526 jxi) SEQUENCE DESCRIPTION: SEQ ID NO:1307 Vo *o.
TTI'GTGCTGA
AAAGAAACCC
CAGACGATI'A
AAAAAGCTTI
AGTTITGTI'AC
ACCACCAATA
AAT
5
I"IAGACT
GTGGATGCGA
F1'GCATTTGT
GTGATI'AAAT
GCTTCTAAAG
CAAGATGCGG
TACAAAAAGT
TTTGAAGCCC
CGCTZ'AGCGT
CAAAAAAGTG
ACTTACAAGC
AACGCTTTAA
GAAGCCTTAA
CCCATCAAGC
TGGAACACGC
GCTCCTI'TTA
CTTTAGA'T
CGTTTGATGG
CGTCTAAAA
CTTTI'GCATI
T1'CCATTTI GT1TTTAGCC'I
AATTTATA
GCTTATTI'GM
CTCCCT1 ATGGTGCAAIl T1TATGAA; CTIT1AGAT1 CATITCTAC2
GAGCAAAAAI
GCGCTAGTG,7
ATI'GATGGG(
GCGCAAAAT)
AATAATGAA2 TCAGCGCTA2 2TrGAAATT(
TTAGAA
ATGAAGAGCA
CCCTAAAGGG
GTAAAATCAA
ATATCGCGCT
TAGGGCATAA
ACGAAACGCC
TGCCTGATTT
TGATGCAAAA
TTGATAAGAT
TCAAAGAAAA
AAAACGCGAG
AITI'GTAT
5
A
CTITTTATI'C
'ITTCGC!CTIT
CTAAATTGTI'
CGAACGCCCA
AGGC T1'GGA
TGGCTI'TGGA
AATTAGCCAG
CCACTATAAA
AATATI'TTGA
AGGTITIAGA
CTGACACGCA
CGATAGCGGA
AAGCCCTTTC
ATA&ATGTGGG
TAAGGGCTfl
CGCATI'TCAC
GTCATGATTI
ATI'ACCGCAC
ATIACGCGC J CT7TGGGAI
LTCGTCTCGTI
7CGCATAAAA'2
CTTACATGGC
LTCGCCAGTI
L GTTGTTTCJ
TAAGGATAK
ATITACAATAj k ATATCCGITT :L ACCATTF
ACACCAATC'
AA.ATTCATTA
CATTCATTCT
AAGCTCTAAA
TGGAATATI'G
AAA.AGAAAAT
TAACGACACC
AATCGGCAAA
AGCGAGCCT
CGCTTCTTTC
GGATTI'AAT
CGTGAGCGCG
TCATTATCTA
CTACGCTTAC
AATGCACCCT
TTI'GATGTIT
AGATGAGCT
GCATTTGCAG
ATIGGTGAGT
CCATACGCAA
CCCTATGTFT
*AGGTAAAAGG
*CTCTAAAGAA
*AAAGGATITA
TAAAAACGCG
TTTTTTGAT
ICT1'GATTTAT
CCATTI'GAAT
CCATGAAGAC
TTCTAGCCCC
CAATTGGGAT
7AGAAGCGGTG
TTTAAAAAAA
STrACGATGCC r' CAGTrGGGAI
;ATTATGGTC
['AGAAAGGGGC
AGGCCAGTAI
k. CGAGGCGCGI k CGCCGCTT k CGCTTTAGGC r AGCCATTAA; r =~AAAAGAc
GAAGAAAAAG
AAAA.TCCCCT
GAGTTI'TTCA
CTTTCACTCA
AAACAAACTT
AATAACGCAG
GACTCTITGA
TTGTATGAGC
TCGCAAGGGA
GGGGCGTTCG
AITGATGCGT
AAAATTGTAA
GCACTCAAAT
AATTCCAACG
AAAGATGAAA
GCTITAGGGC
CATTATTTGC
1'TGAAAATGG
GAAGACACGC
TTAGACAAiAG
GATTATCT
ACCTI
5
AGGCG
GAGGGGGCAA
CTCAAGGGGT
TI'GTCTITAA
GCGCAATTGG
TCTGCGGATI
ACCACGGAG'I
ACGCAAAAAG
*ATGGACTGGC
TTrCGCTAAAG *ATGCTCCCTb,
AGCATCCGCC
CAAACCATGC
AATGATCTGC
GAAGCCCCT;
GAAAAAGCGW
TrAAAAATCC
LTGGCTAGAGC
TrGTI'GTAT(
SACCTCTGAI
CGTTTGAAC(
GGGGCGAAAA
CTITTGAAGCA
AACAGCTTCT
TCGCGCTCAT
CTTTACAAAC
AAGCCGAAGG
AAAGAAACGA
AAGGGCAAAA
TITGCGAGCCA
ATTTGTT1'GA
TAGTTACGGC
GAGACAC
5
TT
CCTACTACGC
CCTTI?1'AAA
CGAACGCTI'A
TITIGCAGGC
ACAACTACCC
GCGATACCCT
TATTAGCCAA
AAAGGGCCAA
ACCGCTrGCT
TGATTGAAGA
GCCTIGC TI'
TGAAAGAATI
AAAATAGCCC
AAAATI'ACCA
ATTTGAGCGC
ITTAAGAGA
CTI'ACTCTC
*TCAAAAACGC
AGAGCAAGGA
AAGATCTCAT
*ACACTAAG
*AAGGGCCCAT
*ATCATCAAGA
ACGATTGGTI
GCGCGTI'GTP
*TAGCGGGTI"
-TTGGGAAATI1
-AAAGAAAGGC
C' TICGTCGCC
AAGAAGAAAJ
CAAAAACGAA
GGCTTTGGAG
ACACAATAAA
TGTGGCTI'TG
TAATACCGCC
GCAAATAGAA
TGAAAGCCAA
AGATGAAGCC
TAATCTAGGG
TTCCAGTATC
TTATCATI'TG
GTATAAAGAT
TGGAGAGTAT
GCCTAATGCG
CAAGCAATI'G
CCGTITGG1GT
TAAAGATTTA
TAAAGCGAGC
CTCT'=T'AC
AGAGCGTTTI
GTTITATIAC
GGGGCTGTrI' TA7.AAGGGGG
AGAAAAGAAG
CAATAACGCG
CAAAGCTI'AT
GGTTTTI'GCG
AATCACCGAG
TTCGCTCATC
CCCTAAAAAG
TAAAAAATTG
CTCTAATATT
CATTTACACC
TTTAGGGCGT
AAGATTGTI'A
GGAAAAITTTA
TCAAAACTTA
AACCTATATC
AGACGATCCG
AGACTI'GAAA
T1'ATIGAT
GGGCGAGTTT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1800 1860 1920 1980 2040 2100 2160 2220 2280 2340 2400 2460 2520 2526 INF ORIAATION FOR SEQ ID NO:1308: SEQUENCE CHARACTERISTICS: LENGTH- 1068 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .1068 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1308
AAGGTTACTA
CGCTGGATCA
GAAAAAATGA
TCCGTAGAAA
ATCACTAGAG
GGGGGCATGG
TTGGTCGCTA
ACCGTTAATG
TTAGGTTATA
ATTTATI'CTA
GATAACATGA
GATGAAGTGG
GTGGATAGGC
GAAGTGGATT
AAAAAAGCCG
TCGCACCATT
ATTGTAGCCA
AGGCGCTA
CTACCATGAT
AACAATACAA
GCGATGTI'GA
AAGATTTGCA
AAGCGAGCAA
TCTTAA.ACGA
CTTTAGCGGT
ATTACTTAGC
GCGTAGGCA.C
AAGACA'ITGT
AATATCT
9
I
ATTCCATTT
GCATGGAAAA
TCACCATAGA
AAAATCTCTT
TAGACCAAGC
ATAATGAAGT
GTGAGGGCTT
AAAAGCAATC
AAAAAAAGTC
GCTGCAAAAC
AGAAAAAACC
AAGGATCTTA
TGGCAAGATC
GGCTI'GAAC
CCATAGGGAT
GATCACTGCG
A'ZTGGAAAAA
CTAGCCATCA,
GCTITTTGAAG
CTTTTAGAAG
AAGATGCGCC
GCTGAAATGA
GCTATGAAAG
-TCTAAAGAAA
AGCGTGCGAG
TCATCGGCAC TAGAAACGAT TTATGGCACT AATAATGAAT
ACGCCTTAGA
AATTAAAAAA
TTTTACCAGA
AITTTGATGT
AAACCGGAGA
GCGAGAGCGT
TGGAGCCGTT
ATGATGATGA
?TGGCTTTGA
CCCATGCGT'
CT'ITAATCAT
TCGCTAAAAG
TAXTCACTGA
AAATTGAAAA
TITITATTGA
CCGGCCGTFI'
AAGAGGCG
GCCTACTI'AT
ACGAGTGCGA
AAGCTTTGCT
GCAACTCATT
GGGTAAGACT
GTATGTGGTA
GTATCAAT1'C
GCGCTI'AGAA
TTATCTAAGG
CGCCATTGTI
TTCAGGGCCT
CATGCAAGTG
AGAGGGGATT
CGCCGCCCTA
TAAAGATTAT
GTCTGAGGGG
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1068 0 9 0 .9 9.* G* 9
AGAGCATAAA
AATI'GATGAA
TTACAACAAG
CGAAAAAAAC
TGGCGTGGAT
CT1'GAAAGCG
GGTGATI'GTA
ACACCAGGCT
GTGCAAAAAT
GCGAGAACTC
GCTGATGAAG
CGCGCGATTT
AATTTATACA
AATI'ACCTCT
GATGAATTTA
TTAGAGGCTA
INFORMATION FOR SEQ ID NO:1309: SEQUENCE CHARACTERISTICS: LENGTH: 1095 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1095 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1309 AAGCTFI TTC TAAAACCCCT AAAAGAAACG AGCCTITGCCC ITGTGGGAGT GGCAAAAAAT ATAAAGATTG TI'GCGCTAAA, AGCGGGCCTA AAAAGGGCTI ATTrGCCAAA TAGATCCTTA
I
ATCFTI'CC
ACTGCTTI'GT
GCGATCATGA
TIAACGCTCT
AAAAAGTI'CC
GCGCATI'CCA
AATGAAGTTT
TTTAATTTGA
GCCGATTTGT
CGCTTTACTA
TATGCGAGCC
GTGC.ATGTCT
ACAATCAACC
TCGGCGATGG,
GCGTCTFI'GA
GCCCTACTCT
GGTAATATCA
TTATCAAGCG
TAGCCI"IT1
ACGGCATGAG
ATACCACAAG
CTAATrTGCT
TGAATGGCGG
TAAATGACGC
TCGTGGGGAA
Tn--=CACCGA TcAA.AGGCGA
TTCAAGCTAT
ATTCTAAAAC
ACCATGGCAT
AATTGGAAAA
ATATCATCAG
TTAGCATGGG
TTAGT
TTATITGCGT
TGGCGTGGCG
TAAGGAATTT
CCCTTATGGG
TTTTAGCCCC
CGTGGTGTI'
CTTAAAAAAC
AAGCTI'GAGA
ATAGAGCCA
TTTTGATTCA
AAGCGCGATC
GCCCATGAAG
AGGCATI'GAA
AAGAGCGTTA
CTCGCTTTTA
GAGCAGTCAA
TTTGATAAAA
GTI'GGCGTGA
GAAAAAAAGC
ATCAGCGAAG
TAFF1'GCAAA
GGGGTTGATT
ATTAATGAAA
TACAGCTTGA
ACAGGTCTCA
GGGCTAAAAT
AGGAGATTAC
GATATTGAAA
GGGTGGTGGC
T'TCATI'GTGC
A'TGGTGGTGA
AAAGAAATCC
GCCAGCCTT
TGG'rFTrAAT
TTTTTGTGAT
AAGTGGTTCA
CCCAAAGTCC
TTTCTAAAGA
ACGATCTCTT
ATTAGATCT
CGCTCTCCCC
CCTATGACAT
CCTTAGGGCT
AATTACGCAA
AACAAAACGG
TCATGCTCAT
TGAACAGGCG
AAAAA.ACCTT
cATTAGTATC
TGTGGCTATG
GAACTACCCC
AGCTTTAGAA
GATT1AAAAGC
AAGGCACATC
CAAAAACCCT
CAATCAAAAA
CATCATGAAA
GAGCTACATG
TTATGATGGG
CGCTTrAAAA
GAATI'TTTTC
TATrI'TAATG
TAAAGAAATC
TTTTI'ATTTG
180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1095 INFORMdATION FOR SEQ ID NO:1310: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 1062 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1 .1062 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1310 0*0
AGAGGCGTGA
TrCAGGATGT
TTTAGAAA
AAAGATTIGA
AAAATTAAAG
AAGAGTGAAA
GCCAAGCAAC
ACGAT1'GCGA
GAACTIGGGG
CAA'ITAAGGG
TrTAGAAGACA
TTAGGGCCTA
GCGCAAAAAA
GATGTGGCTA
AATTACGATA
TCTAAACTCA
AACATTTTAA
CCTATTGAAA
GCATTAAAGA AGAGAGCCAA TITTCTAAACT TTCAGGCATG
TCTACAATFI'
ACGATCTGAT
AATTACACGA
CCTI'GCACGC
ACACTAXAGA
CCAACATGGC
GGCTGTATAT
GGCGAAGCGG
ATCTGTI'ACG
AAGACGGCGA
AAGTGGAGAA
ATGAGCAACG
TTAGCGCTAA
AAGCCTTTGA
AAGAAGATT
TATI'GTGGC
AGAAGTGGTG
CTATAAGAGT
TAAGGGTCAG
TI'TACTCAAA
AGCTGAAATC
AGGCAGGGGC
CATTGGCACT
GCGTCAAGGC
CA'FTTGGG
ACACATTGAA,
CTTGCATTr
AACAAGCGTG
AATCGCTGAA
CCATCAAAAC
TAACGCTAGC
TGAAAAACTC
ACCTTAGCCG
ACAGGCACGG
TCCATCCCTA
GAAAAAGAAA
CCCG??I'TAG
AAAGAGCGCA
ATCAAAGACG
GTTGATATTA
GAAAGGCATG
GATCCGGGAG
AGCGATAGGA
TTCAAGCTCG
GACAGCCGTA
TATAATCTI'A
AACAGAGAAT
CTGTCTGAAG
GTTGAAT'AG
AAAAGCGGAT
ATATTACTTI
CTCAAACCGA
CTAATCTAGC
AATTTGACGC
TCGGCACGGC
TCCCTCACAC
CCGGGCTrAA
AGCTCACTGA
AGAGCCGTAG
TGAGTCAGTT
CTAAGGGGGT
TTACAAGAGC
AGCATI'GTT
GAGATGAAT'
ACGCGCTCAA
AGGAACTITI'
AAGATT'AGA
TA
CCAAAATTAT
AGCCACAGAA
GATCAAGCGA
TGTGATCCTT
TAGCATTGAA
CGTI'TTAAAC
AGGGGCGGT
TGAAG'ITAAA
GATTGACAAT
TTATr'TGAGC
GATGGAAAAA
GGTGGAAAAC
AGAATACGAT
ATITAGACATC
TCAAATCTI'
AGGGCTTAAA
AAAAGCCTCC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1062 INFORMATION FOR SEQ ID NO:1311: SEQUENCE CHARACTERISTICS: LENGTH: 321 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .321 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1311
ATGCAGAAGT
TAGCAGCGA
GATCAGI'AG
ACCGATCACT
TI'AGAGCCTA
AAAACGGTTG
T7171TCTCTCG
TI'GATATTGA
TGAGCCTGAG
TAAAAGATCT
AGCCTAAGGG
AAATCGGAAG
TI'TTAGAAGG
TGAAGTAACA
CGATAAGCTr
TAACGATTTG
CAAAGAAGAT
TGGGCGT'GC
GAAGCTCAAG
TTAGAAAAAG
CATGAAAAAA
AGTCCTAACT
CCTITI'ATIT
CTAATAGCAT
CGGTGGATAG
TCAAACATT'
TGGGAGGTAA
TGTGAGCGCT
TAAATTAAGC
GGGGCGCAAT
GCGCTI'GATT
TAAGGATATG
120 180 240 300 321 nfl .n.
p INFORMATION FOR SEQ ID NO:1312: SEQUENCE CHARACTERISTICS: LENGTH: 825 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .825 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1312 p p flee p
AAAAACCAAA
AAATCTATTA
TTTGAACCCC
TCTAACGACA
CACACCAAAC
AAAGAAAGGC
GAAAAAACCG
AATGAAAAAG
ACTAAAGAAA
TTAGCCACAG
GAGTTAAAAA
ACCAAGCTAA
AAAACAGAAT
GACAAAGAAA
TACTTCAAAT
CAGATCTTAA
'ITAGAAAACT
CCCAAGAAAA
CGACTGA&AC
TAGAAAGAGA
AATTACAAAA
CCGATTGGCT
AAACAGAGCT
AAAAAGAAA
ACTCTAAGCA
AAACAGATAA
TAAATAACAA
ACCTAACTAA
CCCACTGCTT
A.GATCGCCTT
CTCTCATTTT
CCCAAAAGAC
CACCGAACTA
AAATAAAAAC
ACAAGTGAAT
AAGAGAAAAA
GACTGAAAAA
CCTAACTAAA
AGTTITAGAA
AACAGATCTG
GATTACTGGG
AGAAAGCAGA
CCACCCCCCC
AAAAAAT'AG
ATAGTTATAG
GCTTTAAAAT
GTTGAAGAAA
CTAACTGCAG
GAGTTAAAAA
GAAAATCTAA
AATAAAGTGC
GAAAAAACCG
AATGAAAAAG
ACTGAAAAAA
TTAGCCACAG
CAAAGAAAAC
CCAATAATGA
AAGATCTTAA
GTAATTTGTI'
CCACCAA.Tr
ATAAAGCGCT
ACAAAGAAAA
ACTCTAAGCA
CCAAAGACAG
TAACCACAGA
AATCACAAAA
CCGATCTGAC
ATCAAAGGCT
AAAAAGAAAG
CTAAC
AGAGCTTTTA
ATI'AGAAGAC
T GGAAAATCC
CCACGAGAAA
APLCCACAGAA
CCTAACTAAA
AGTTTTAGAA
AGAAAACCTA
AAAAGAAAGG
ACAAGTGAAT
CAACGAAAAC
AACCACAGAA
GTTAGCCGCA
932 INFORMATION FOR SEQ ID NO:1313: SEQUENCE CHARACTERISTICS: LENGTH: 390 base pairs MB TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .390 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1313 p
GCGCTTTCTA
CATCGI'1'T
TCTCGCTCAT
GCTITAFTT
AGCCTTTCTT
AATAAGCGTG
TTAGTGAGCT
ATTGTTI'GAG CTTGTCAGT CTAGAAACCC ATGCGCATCT TAGTGAGCGC GGTAACTTGG CTITAGTCAG CTCGGTGATT TFI'CTGTTGT CAATTcTCTr TGTITTTCTTI' AGCTAAAATG TGTTATrGTT TTGCCATAAT
AGGCGTTGGT
TGCAATCGCG
TGGTI'GAGCT
T1'ATGGGTTA T71TCTTCAG TC'1ITCCG
TI'TCTITCTC
CTCGCTCTTG
TGTCGT1'TTC
GCTCGGTGTI'
TCAGCCGATC
1T171CAGTTC
TAAATTGGTG
TTCGAGACTA
GGTG-TI'AGT
TTCTC'1T1'l~
TCTGGCTGCT
TGCTTTITCT
120 180 240 300 360 390 INFORMATION FOR SEQ ID NO:1314: Wi SEQUENCE CHARACTERISTICS: LENGTH: 981 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .981 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1314
ATGGGAACGC
CGCATCAGTG
GCAGAAACTA
1-CATAACAA
TTATCTGTAA
AAGCTCACTA
ACACGCTTAT
AAAGAAAGGC
TCATTGAAAA
AGTAGAAGA
GCGAGTIAAA
AAGACAAGCT
AAATCAGCGG
AAGAAAAAGC
TAGCAGCCAG
TAAAAAGAGA
ATGGTITGGC
CGAAAACACC
AGACGCTAAC
AACCAAAGAA
GITAGAACAC
AGAACTGAAA
AGATCGGCTG
AAACACCGAG
TrCTCTCAAA GAAT1'GTI'AA GATCAAT1'AC
AACACCGAGT
TCTAACGATC
ACGGAAAAAG
ACTGAAGAAA
CTAACCCATA
TCAGAGAAGA
GAGAAAGAGA
GGCAAAAAAA
TATTCGCAGA
AATI'ATGGCA
ACATrI-rAGC
AAAGAGAATT
AAATCACCGA
ATI'AGAAGCT
ATACTIAGCT
CGACAAGTIA
AAACGAAAGC
AAACAATAAC
TAAAGAAAAC
GACAACAGA
GCTGAcTAAA
GAAAATAAAG
AATGAGCGAG
GAAAAACGAT
TI'AGAAAGCG
AACTCTAATG
GAGCGAGAAA
TI'ACACAACA
GAAGAAGAGA
TGCAACCAC
CACTAACCAC CGAAAACGAC AAGCTCAACC ATAGTCTCGA ACAAGAGCGA GCGCGATrGC GCACCAATFI' AGAGAAAGAA AACCAACGCC CTCAAAAAAG CTGGAAAAC ACTAACAATC TCCAATI'AGC ACAAGCTAAA GAAAAAATAG TCGCACGCTI' GAAGAGCTTA GAGGGTATGG GGCGITTAGC GAGCGCAAAC GAGGATTTAA ACATCGCCCT CAAAGAGAGG GTI'GATGGCT AAAAACCACA A
ACCAAGTTAC
AAGATGCGCA
TAACTGACAA
AATTACGGCA
CCATAGAGAA
AAGCCAAAAG
AACGCCAAAA
TGAACGAGCA
CGCGCTC:AC'17
TGGGTFL'CTA
GCTCAAACAA
AGCTTTAGAA
AAGCGAGCTG
CGATCTCGAC
CCGAAAATTA
GCTCTCCAAA
INFORMATION FOR SEQ ID NO:1315: SEQUENCE CHARACTERISTICS: LENGTH: 279 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .279 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1315 TTTAAAACCA TTGAACGAAA AAAGGATATA AAATGAAAAC TI'ATTGAGCG GT1'GTTCTAG TCTrCAAAAG ACGCT1'CTAC CCTTATI'CTr CTAACTTAAA
CGATTTTAAA
AATTAAAAAT
C'ITTGATGCT
CAAAAAAGAA
CCATrGGGAT TrAAACGGAT TGACAAAAAT GGTATTATGA TCGGCACACT CAGCGTITCG CTTGTCTCCC GCGCAATACA TTCCTAAGGG
TCTACATC
TTTACAAAAC
CGGTGCGTZ'G
TAAAGACCAT
CTITTIGAC
S.
S S INFORMATION FOR SEQ ID NO:1316: SEQUENCE CHARACTERISTICS: LENGTH: 909 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .909 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1316 AGcTTAATA AGGGTCTGGC AT1'GTrFFI'A GTCAAAAAAA TAGGCGTGGT AATAATGATI'
TTAGTCTGCT
GAGCAAGAAA
AGCGAAACGA
TI'CCAACTGA
AATGAGCCAA
AATGAAGACA
ACAAAAAACC
GATATTATCA
AAGCGTTT
GACACTAAAA
AATAACGGTA
GATAATGTT
ATGGTGTTAA
GATTTGGATI'
AAGGAAAGT
TITTAGCTTG
ATGACGGCTC
T TITTACA.
CTAAAGATGA
GCGATAATAG
ACGcTAATAA
CAAAACTCAT
TGAGTAAAGA
TAAAAGATCA
CGCAAATCGC
GcTFTGAGT
ATACGATAGA
AAAAGCATTC
TTrAAAAAAGA CTCrGcAAGAG
TAAACGCCCC
AAAcATGGTG
AGACAATI'CT
TGAAAAAAAC
TAGTCAAAAA
TGAATATTCC
AGGGGATCAA
AAACGATAA
GCAAATTAAG
AAGGCCTrTT
GAATAAGGCT
AACCGATAA
GCGCTT'AAG
AGcTTTATCA AGcTATGTGG
TATCAGCCTA
TI'TAACCCTG
CTACTCTCAT
AATCCGTTCC
cAACAAGATT TGG?1'GATAG
GATCGCCAGA
GGCAAAATTIT
TATGAATCGT
TTAGATACTA
TrAGACAGCC
AGCGATACGG
AAATGCAAAA
ATTCGGAT'A
TAGAGGAAAG
AAAATTCCGT
ACCCAAACGA
TI'TACAAGCC
TCTACCCCCT
AAATCCAATC
TCCAAACTT'
CTrCGTATGT
TTI'TGTTAGA
TGGAGAITI'C
AGCATAAAGC
AACTCTITIT
AAAAGCCCAA
TGAAGTCTTT
AAACGCTT
GATTTTACTG
TCCCAATAAC
cAAAAGAAA
AAAAAATGGG
CAAAGCCTIG
CACTTITAAT
TITATACCACC
AAAAAAGAGC
AAA~GTGTCAA
CATCAGTAI'
AGAATGTCTT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 909 INFORMATION FOR SEQ ID NO:1317: SEQUENCE CHARACTERISTICS: LENGTH: 363 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .363 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1317 a a. a a.
GCATGGTI'AA
GGAGTGGTGT
ATTGAAAAGA
CTTTCAGATA
GAAGCI I"CA
GATACGGATA
GAG
AAAGTAGGGT
GGGGGAAATC
CCCAAACCAA
TGGATTATAG
AGGGGGATAG
AAGTTTATGT
TTTAATGAAA
CTTGCCTAAG
AGATGAAAAA
CTTGTCCTCA
AATAGAGAT
GCTI'CTAAGA
CGCCTTGCTG
TGGGCAAAAG
ATITTAGTGT
GCCAGACAAA
AAGGCTGGTG
ATCACTAAGA
TTGCGCT1'AT
ATI'GCTCAAA
GTGGGATGAG
ACGCCTTAGA
AGCTAAAGGC
AGCATGTCGC
TTTGGTG LTG
AGAGATGCGG
CGATATATIG
GAAAGTGATG
CACTI'TTATT
TTTAATGAAT
INFORMATION FOR SEQ ID 14:1318: SEQUENCE CHARACTERISTICS: LENGTH: 9-18 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) AN~TI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miSC-feature LOCATION .918 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1318
GGATTGATAA
AGCGCAGAGC
CTTTATGGGA.
TTAGTGGCGT
GATAATAAGT
T1'GAATAATG
AGGATCAATC
CAGTT1'TCCA
ATGGGGGATT
CCGGTGAGTT
GTGCGAATCG
TACGCTAGAG
TTCACGGACA
CAAGGCACGC
ATCACGCGCT
TGAAAAAGAT
CTAAGTGGTA
GTGGTTCAGC
CTATTAGCGT
TAAAATCCAG
TAGAAATI'GT
AAAACTTGTI'
CCTrAATGCC
TATTGGCTAA
CGTTAGAAAA
CI'TTGATGA
TGCTAACCCC
GTGCTAATGG
CTGTATTGAA
TGCAATCTT
TATTCTTGCA
TAGCAAGCC
CAC1'TCTAAA
GGTGGTCA.AT
CGATTCACAA
CAATCAAGAA
TTTGCAGGGT
TAAGGTTTGC
AGCGGCGCCT
TTATGAAAAA
TAACAGCGAC
TAGCGATGAA
CATCACACGC
TAGGAGTCTI
ACTTTATAAA
TGcCT1'GTGG
TATAACAAAA
GAGGCTTCTA
TCACAAATCC
ACGATCAACT
GCGCAAAAAG
TTAAGGGATA
AAAGGGGTTI'
ATGGAAAGGA
ATCTATTACC
ACAGAGATTA
GAAAAACTTr
ATTAGAGTGA
GAAGTGGATG
GAATTGAAAG
CTFI'TGTGGG
CAAACGCCCA
AACAAAAAGC
ACATTCAAAA
TAAAAACCGA
GGATCTACTA
AGTATAACGC
TTTACAAACA
TrrI'AAAAGC
AAAACGCTTI'
AAAACGCTCT
ATCAAATCAA
TTATTAGCGC
AAAAGAATAA
TGCCAATTI'A
AAAAGGCTAT
GTTAGCGGAT
AAGTCGTGTG
TGACFI'GGAA
CACCAGAGTG
TCTTI'ATGGG
ATCCAAGAGC
GTATTCTGTC
CAAACCTAAA
CATGAGTGCT
AAATGAAGTI'
GAGCGATTGT
GAATTTTGCT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 918 GTTATGCCAA TAAAGAAGGA CAAGGCAATA
CAGGGCTA
INFORMATION FOR SEQ ID NO:1319: SEQUENCE CHARACTERISTICS: LENGTH: 1017 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geriomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc~feature LOCATION .1017 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1319
CCCCAAAGAG
rTAAGGATTG
GGGGGTITGG
GCGGGCAGCT
CAGCATGAAA
AGAGTTTATG
ATTCCTAGAA
CAGTATATIT
CGAGCGITTG
TTITGAXTITGT
ACTCAAAAAG
TGGGTGGGAC
CAAAAATACG
GGAGCGGAG',!
CGCTTTCAT"I
TCCCATAAGP
TTAAAGGTGC
TTGTTTTTAG
cGGTGGTGAT
GGCAGGCGAT
TTATTATI'GC
AcGCCTTIGCA
TTAATI'TAGC
GTGCCATAGA
TGGGCGAAAT
GCA7I'GGTGG
ATGTGGAATA
TGGATTGA
TTTTGGGCTT
CAAI'GAAAC
TTrGATTT
TTAGAAGTTT
TCAACGCTT
*TGAAGGACGA
GGTGCGATTC
GCTAGTAGCG
TTTAGAGGG
TCTTTTTAGC
ACQCCTATT
GGTGrTCTT
AGAAAAGCCC
TTTAAGCCTT
GGGGACGATG
TACCGGCACC
AACGATI'AAA
TAATAACACC
TTI'CAGCGAT
TGAAAGAGAG
GCATGAAATG
AGACGTCTTC
TAAAGGGTT
TrGCTCGCTA TCCCCCAAAT ATGGCTGGAA
TCGGGGCACT
CTAAACACGC
GTTIAGCGG
TCTCAAAACG
TTTTTA'rTGC
TTAGTCGTGG
TrGT1'AGAAA
AATATCCATC
GCTTGGGTGA
AAGCGTTATG
TATTCTTTAG
TTAGCCT1'TC
GACGCTTTTA
GATATTAATT
ACTACAGACG
TTTCCTAATT
ATCAATI'TGT
CCACCCAAAA
TAGCGAGCGC
CGACAAAACC
AACACCATAT
CGGCATTGAT
ACACGCTCAA
AGAAGGAATr
CGATTTCTAA
ATAGCCCGAA
AGGGCTTAAT
TGCGTTATAA
CTCAAATCAA
ATCAGGCCGG
TrTAGTGGGC
CATTGGGGCT
GATTTTAGTG
GAGCGTGTTT
ACAAAAAAGA
TTI'ATGGCTC
TAGCAGCGAG
CCCTATCAAG
TAGGGGCGAT
AAACCCTITG
TAATC7TI7 G
AGAAGACGCT
TTTGA2TT
CAAAGCTTAT
AAGTI TGAA
AGAGCTGGAT
TATTGTT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1017 INFORMATION FOR SEQ ID NO:1320: SEQUENCE CHARACTERISTICS: LENGTH: 432 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .432 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1320
GGAGCAAAAA
AAAGCCCATG
GAGCCTAAAA
AACCCGCAAG
TCTGTAAGGT
GCGTTAAAAC
AATrI'GCCA
GGCCAAGGTA
TGAAAAAAAT
AAGTGAGCGC
TGAAAATCAA
CAAGAGAGGA
ATTCTITTAGG
TAGAAAATCA
AAAACCCTGA
GA
TGGTITTGAGC
TGAAGAGATT
CCACACGAAG
TTAGAGGTG
GGGCGTGGCG
AAACGCTAGT
AGAATTCGCC
TTGTGTTTGG
GCGGATATTI'
GGGTTTTGCG
CCACTACTCA
ATGGACGATA
TGGACAATG3
CAXTTTTTG
TTTTGAGTT
TCTACAXACT
CTAAAGGCGT
ATGAAAALAGA
AAAGCAAGGT
TGATGCTCAA
AAATGAGACT
GGGTT7=FA
CAA.CGCCAAA
GTTCCTCCCT
AATCCCTGCG
TAGGGGAATG
TACAGAAATC
TCCTAAAAAT
INFORMATION FOR SEQ ID NO:1321: SEQUENCE CHARACTERISTICS: LENGTH: 1584 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genemic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE:- NAME/KEY: misc-feature LOCATION .1584 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1321 CATGAGTTTT TAGCTAFI'AA TGAATTGATG CAAAAAGAGC TTTTAGAAAA AATTGAGGTG GAAACGCTT TAAACAATTA CCAAAAAGAA GTGGTGGGCT TCATTCCCTA TGCCACCATG CAAGGCATT FTGTGCGCCC ITIAGACAAG CATGTITTAG GTI'ATGTGGG GGTGGCAAGT CAATACAGCC AGATI'GTAGG CAAAACCGGC
TITGACGTGT
ATCCAAAAGT
AATTCGCTCT
CAATCCCTT
CGCTACTACC
TTACAAGATT
ATTGAAAAAG
TTTI'GCCCAG
FFI7TCCCTAA
ATAACCATAA
ATACCAAACT
CTAATAACGC
TAAAAGACGA
AATACAACAA
CAGATTGAAA
ri 1"CCCAAA
CCTCATI'AAA
CATCCAAACT
Tfl'AGCTTCG
TGAAGAGAAT
GTITITACAA
GGCAAGGTGG
GAGGTCGTGC
AAAGAAGCAC
AATGGGGAAT
GGGATCAGTC
CGCTTCGCTA
Tr"I7FrAGAAA
GTGGGCAAGC
AAAGCCATTA
GAAAAACTCT
CCGAATGAAT
GACTGGCGCG
CCTT1'GCAGG,
TTIGCTATCC
CTCCAAGCCT
CAT1'CCACAA
GAAATCGCTC
TCCCATGCGT
TTAGTAGAAC
AAACTCTATG
GTTATAAAAT
CACCACGCTC
ACAAGCTCTI'
TGCTCGTTGC
AAGACAAATG
ATGCCTTGTA
ACCTTCATAT
GCAAATTCAG
GGGAGTCCGT
CTAAAACCTT
TTGTGGGGAT
TTGGGGACAC
TGTTAGCCTA
ATAACCAACA
TGCGCGTGGG
GAGGTTCTAA
AAAACATCGT
GGATTACGGC
ATGGGGAGG
AGCTI'GGCTA
CATACATGTC
CAATAACCAC
TGTAAATAAG
AGGAAGTTAC
GCAAAAACTC
TCCGCCGGGA
CACAGAAAAC
GGACTGGAAA
GGATGTGTAT
AAGGGAAGTG
TGTGCCGGAT
GCTCATTACT
CACAGGACTC
ACCGCTCAA
CATGTATGAA
GGTI'ACCTTA
CAATCGCATG
ATI'CTTGCCC
AGGGTCAAAA
TCTI'
AATGCGCTCA
TCGCAATTGA
AGAGGGCCTA
CCTGAATACA
CAAGATGATA
TCTGTGGTI'A
ACCACTATCC
AAAACAGGGC
TTATAAGT
GGCTTTGGGG
APATTTGTGGA
GCTATI'GGGC
ATTGCGACAG
GACCCCCTGA
GTGTGTAACC
GCGTGTAAA
AAAGAAAAG
TATGAAAAAC
CTAGGGGGCT
ATCAAGAAT1'
GTTTAGACAA
TI'AGTGAT
ATTTGAACGA
TTTATAACCC
AAATGGGCGT
CCACACCGCC
ATGGCAATIC
TTGGGCTTGA
AAAAAACGGG
AGCTCAAACG
AAGGCTCTTT
GCAAACTGGC
ATAGTTTTCA
ATAAAGACGG
CCGGCACCGC
ATATGGAATA
CCAAATACGC
TGTI'AGTGAA
AGCCACCTTA
ACGCTI'CCAA
GGATGCAGAA
ITI'TGTAGGC
TTTA'FIAAAC
GGGGI'AAGC
?1'TrATTGAA TAA?1'TGTAT
AATCTCTATA
CGT1'GATFI'G
CTI'CAATCAA
TTTAGCCACG
AACGCCTCAT
AAAAAAGAAG
CACCGCTI'AT
GCAAGTCGTA
TTTCCATCGA
TATCACTATI'
AATGAGCAAC
480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1584 S. 55..
S
S. S INFORMATION FOR SEQ ID NO:1322: SEQUENCE CHARACTERISTICS: LENGTH: 840 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular' (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .840 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1322 .10 00 0
ATAATITTG
GCTATTGTT'
GACCACAAAA
TTGCAATCAG
ACGGA'ITATG
CAGCACCGCC
GCCAATATCC
CTTAAAAAAG
ATTITACTCC
GAG??I'GATA
TI'GCCTAAGG
GCAAAACTCA
GCCTCTCGTG
AGCGAAAAGA
TTAATAAAGG
TAGGTTTT
TCACTCGTGA
TTGTGGATGA
TGTTGCCTAA
CTI'ATTI'GGA
ATGTGGAGCC
GCTCAGTGAT
ATAAACAAGG
TTGTCAAAAA
TTAGGGGA
CCGGAGCCTT
AGGATAATGC
CCAGGAAAT'
GGTI
5
IITATG
TAACCTITI'A
GCTIAAAGTG
TGAAAGAG
TI'TAGCGCTC
TCGGTAAT
TTTAAGATT
TGCTGTGCCA
CCTTATCGCT
TCCTTACAAC
TGTGGATGGG
ATTITCAGAA
GCAAGATGAA
CATTTTGGAT
AACATATTCA
GACGCCAAAC
GGCGCTAACC
AAAGGGATCA.
AATGACGGCT
TI'GGACAGAA
TA'ITCTCAAA
AATGATCCGG
CTCAAAGACC
ATCAAAATCA
GCTATCATAA
GATAAGGACT
GCGATAAAAG
ACCTATAAGG
AGCGTATTAT
ACCACAAAGA
CTGTGCCGCA
AATI'AGTGAT
CTITAGACGC
AAATGCACCT
AAATCACAGA
CCAATCAAGG
CAAGCAATCT
AACCCCTAGA
CAGGGAATTA
CGCCTTATGC
CGTI'GATTGA
GGGCGATTAT
TTGCGTAACC
AAAAAAAGAA
TGCGCAAATC
CGTGTCTTT
GAATIACT'C
TGTGGTTTG
CATITAAAAAC
CAGGGCGTI'G
ATACGCTACG
AGCTGCGT'A
TGCCTTGCAA
TAATCTTGTA
AGCCITACAG
CCCGGCrr 120 180 240 300 360 420 480 540 600 660 720 780 840 INFORMATION FOR SEQ ID NO:1323: SEQUENCE CHARACTERISTICS: LENGTH: 978 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 978 (xi) SEQUENCE DESCRIPTION: SEQ ID, NO:1323 *9 9 9* *9
S
S S 555 5
ATGATGATAA
CTTTCGGCGT
GCGAAAAGCT
GTGGTGTCTC
TTATTGCTTI
AATTTGGG
TCCATCACGG
GGGCTGTI'AG
ATTGGGCAAA
ATAATGCTGC
GCAAGTGTCC
ATGGTTATIT
AGCCAATTI'
GTGGGGAGT1' GCAATGGT1 T
GTGATCTT
CAAAATGAGG
CCAAACAATC
TTATTITTTAA
TTGAAATGGA
TTGGCTCATI'
TTCFTI'CGC
TGCTICTCCT
CTTCTTIAGT
CGTTAGGGAG
TITTGGATTG
TTATGTGGAA
CTATATTAAT
CTGGGCATI'
CTCCTGACAT
TTTTGT'CGG
TAGTCAT'TG
TGCAGA'ITI
GTATTCAC
GTATCAAAGA
CACCACGGAG
GAGCGCAACA
GCCCTTGATG
TCTITI.T'1
TTCTCGTATG
CATTCGTGTC
TTCGTIAGCG
GCGATCCACT
ATTGCTCCCG
GAAACGCCCG
CACCACTTAT
TACAACGCTA
CCGTTTGTAT
CCCGCAACTC
CTI'GTGGGGG
TrCGCrrI'AA
TTGTCCCTG
GTGGGGC LTA
CTGCTTAGC!G
TTCAGCCATA
GGTATCGCT
GCGCCAAGAA
ATGATI'ITAG
TTTGGCGTGA
CATCTACCGA
CTITI'AGTGG
AGCTATATTG
ATGTTGTTTG
GCGAAAAATT
TTGCTTr
ATTGGGATTA
TGCGGGTT
TTGCACT1'CT
TGATCACTGC
CTAAAATTGA
TCCTITCAGC
TI'GCCCACTC
ACAAAAAACA
GGTTGCCGCT
TI'GGGGGCGT
GTAGAAACGC
GGA'TIATFI'
AGCCTTAT
TGTI'GGGIT
CAAGAAAATT
TGTTTAAAAA
CTTCACTCAC
TGTGTTI'T CG
GTCAGACATI
TTATGCATGG
AAGGAAACGC
GTI'AGCGTGG
TATITTI'GG
ACAGGCCTTA
TGGGAGGATC
TGCGACTCTT
CGGCACGCTC
GCTI'GTGATC
CAT1'CAAATC
AGCAGACGTG
TATCGCTII
CTTAGAGTGG
CA?1'ACGTTA 120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 978 INFORMATION FOR SEQ ID NO:1324: SEQUENCE CHARACTERISTICS: LENGTH: 264 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .264 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1324 AAGGGCATTC AAA.AGAAACA AAATCTrAAA GAG GTG GCT1' TAGACGCTr1' AGCATCAATI' ACTACCATTI' TAACGGCTCT CTCACCGCTC CTCCTGCAC: GCATGGTTIG TCATAGAAGA ACCTFI'GGAA GTTrCTGCCA AACAATI'GGC AAACGCATGA AAAATTCGCC CAACCAACGC CCCGTCCAGC CTGACTACAA
CI'GCCTAAA
AGAGGGGGTG
TGAAATCAAA
CACCGTGATC
120 180 240 ATI'AAAAGCT CGGCTGAGAC CCGC INFORMATION FOR SEQ ID NO:l325: SEQUENCE CHARACTERISTICS: LENGTH: 450 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .450 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1325
S
4 4
S
*4*5 4c *6 9 9 4* 4 b.
.549
S
Sfl.
9* 4 *94 t
AGGATAATTA
GGCGCTGAAA
AAATTGCACA
GAGCATTACT
CCTAAAGCGG
ATCAATTATA
TyTTAATCA
GGGCGTTTGT
AAATGAAAAA
ACACCAAATG
AAGATTTI'GA
ACCACACGCA
TC-1:1:TTCAC
GAGGGCATGA
ATAATAAAAC
TGGTGTTAGC
AACTTI'TTG
GGATI'ATAAA
AGTGTGCAAA
AGATAAAGCC
CCACcATACT
CTATGTGTTG
CAGGCCTTTG
GATTGGGTTT
ATCGCTTTAG
AATAAAGAAA
AGCGGTAAAA
GATTTGCAAT
TrAAAGGCTT
GATAATGTGC
AGCGCGCATI
CGCTTACGGC
ATGGCCCGCA
GCCAATCGCC
TCAAATACGC
CGTTTGAGCC
ATFITCCACGC
TCGTGCATAA
TTCTCTTATA
CCGCTGGGAC
cATCAACAI'
CGCTTCTAAA
GACTAACCAC
CCCTATGGAG
AGACGCTAAA
INFORMATION FOR SEQ ID NO:132 6 SEQUENCE CHARACTERISTICS: LENGTH: 1149 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-.feature LOCATION .1149 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:132 6
ATGCCTGTTA
GCAAAAGAAA
GAAGCGATAA
GTIAAGACTG
GGTGTAACAG
AAAGAAGTGG
TAAGAGTT
AGAAAGTTT
AAGACTCGAT
CGGATGATA
CGATAACAGC
CTCAAGCTCA
AGTAATGCTr
TAAGAATGTG
AAAAAAACAA
TTrAAAAACG cATCT1'ATG
AAAGGAAGCT
GcAACAATGA TGATGAAAT GGAATATCTA TAATGGGGAT ATTAAAAAAA GCGATI'GGAT CATCCTAACT CATGGTTrAA AATGTGTGTT TTGCTGATGA GAAAACGCTA GGGATAGAGC
AGTAAA.AACG
TGcTFI'GG
ATGCGGGAAT
TTCAGCAATA
CCAATCCAAA
GAACAAGAGT
120 180 240 300 360
GGGATAGAAC
GAAAAACAAA
CAAGAAAAAC
CAACAAAAGA
AAAGCAGAAC
AAGGCTGGCA
AATCAAACCC
GGATCAAAAG
TCACAAAAAG
GAACTAGATC
CGCTCTAAAG
CACCTI'CAA
GAAATAAAAG
TGGAACAAGA
AGACAGAACA
AAAAGACAAG
CAGAACAGGA
AAAATI'GCCA
TGCTATAGA
CTATCCAGCC
CGCAAGAGCT
CTATCGCTAA
CTAGAGATTT
CTCAAGCTAA
CCTCTCAAAG
TAGTTGCTAA
AGAGCAAAAG
AGAAAAACAA
cAATATAGAG
AAAACAAAAG
AGAAAATCAT
AATAGAAGCT
AAAACACCTC
TATCGCTTAT
ACAAGTGGAT
TAACGCTACA
AATGCTIGAA
CCTTTrGCTC
TACCGAGAAA
ACAGAACAAG
AAGACAGAAC
ACTAACAATC
ACAAACAATA
AATCAATTCT
GAATGCAAAA
CCAAACTCCA
TTGCAAAAAG
TrFI'ATAGGC
GAAGAATGGC
ATGAGGAGTT
GTTCAAAAA
AAAGTAGAAA
AAAXAACAAAA
AAGAAAAACA
AAATAAAAGT
CGCAAAAAGA
TTA'FIAAAAA
CCCCTAAACC
AACAACCCCA
AGCTAGAATC
CAAGTrCTAT
AAAAAGAAAA
TAAAACCAGA
TATTTGCTGA
AAGCGGGTTA
GACAGAACAA
AAAGACAGAA
AGAACAAGAA
TTTGGTIAAC
ATTAGGAAT1'
CACAAAAACC
TTCTCAAAGA
TCTGCCCTAT
CGCTTATTTA
TTTAAAAATA
CCCACAAGCC
TGT1'AGTAAA
TGGTI'ATAGT
420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1149
S
S
AAAAGGATG
INFORMATION FOR SEQ ID NO:1327: SEQUENCE CHARACTERISTICS: LENGTH: 996 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .996 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1327 00. 1
AATAAAAGGA
AAAGACACGC
ATGGAATTTC
GAAAAAATGG
ACTCAAGAAG
ATCGTGGATA
GCCTI'AGAG
GGTGGCCGTG
GGGTATGAAT
GTGGATAAGG
GATITTAAAG
IAAAATCG
CTAGAGCCTA
GGCGATTTAA
ATCGTGA.ATG
GCCACTCAAG
AATATCGCTA
AGAACATTAA
TGACTGGGGA
CTGAGCCGGT
GCGTAGCGTT
AAACCGGTCA
GATTGAAGAG
AGACTATCCG
GGCAATACGG
TTGTGAATGA
GTATCCAAGA
TTACCCTITA
CTGGCTCTAT
TGATGAAAGT
ACAGAAGAAG
CTTI'CGTGCC
GGCGTGGGAC
AGGAAATCGT
AGAAGTITAT
CACGCTITGC
CATCACATC
AGGCAAGCTT
AACCCTTATT
AGAATTTAAG
CTCAAGCGTG
GCATGTGT
ATCTGGG
AGCGATGCAA
TGATGGGAGC
GGCGTTTAAA
GGAAGTGGAA
At'GGCAAATC
G'ITAGTGGAA
TTACTCTATG
GGAAAAACGC
GCGGGCGA6A
GATGAAAAGA
GCTGTGGAGC
GCTGAAGAAG
GGTGGTATGG
GTGGAAGCTG
AGCAAAGAGC
ATCAAGCTTG
GGCGTGATCC
AATGGCG'TT1
TACCATGATG
GAAGCGAGTC
GTCCCTGAAG
AA?1'CTATGG
TTI'GCGCGTT
ATGCGGTGGT
CTAAAACGAA
ATCCAAGCTI'
GTGAATI'GCA
AAATCGGTCA
ATAAATACGC
AGCCTAAAGA
CTAAAGAATA
TGGCAGGCTA
TGGATTCTTC
GTGCGGCTAA
AATACATGGG
ACGATAGATT
CGTGGGCTIG
TTAGAGAGA
ACCAGACCAG
TAGGGTGATG
CCTAGAA.ATC
GCCGCAAGTC
TAAGCAAAGT
GCCTGGCAGT
TATCCCTGCG
TCCGGTGGTG
AGAAATGGCG
CCCGGTTrA
CGATGTGATT
AGGTITTGAAA
TI'TGCGATCA
AGTGCCTAGC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 996 ATGTFTGGTT ATTCTACGGA GAGTI'TGACC ACTATGGCGA
AAAGGC
INFORMATION FOR SEQ ID NO:1328:
SEQUENCE-CHARACTERISTICS:
LENGTH: 327 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geriomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .327.
(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1328
TCTAAAAGGG
ACTCGTAAAA
TCTI'TCAAAA
AATCCTGTAG
TCA'TTTA
GTGTCTAACA
CGTTCGCAAG
GGGGTTTAGA
AATATI'GGGC
GCGTTCTAAC
ATI'CTTGTITr
GGCTTAAAGC
CTCITI'AGTG
AACCGTAGGG
GTTTAAAAGA
GCCTAAAGT
TTGCGCGATA
GGTGGTA
TCTTCTAAGC
GGGCGGATAG
GCGGGATTGT
TCAAAAATAA
AAGTATTCTA
TGTTITI'GAG
CCCCCACTAA
TTTCAAACTC
TCTGTTGGTG
AATGGGCCAA
GGACAAAGAA
AAACCCCTTT
TAGGGTAAAA
TTI'GCTAAGC
AGTCAAAGCG
0* 4.
4.
*4*4 4* 4.
4 *4 4 4* 44 INFORMATION FOR SEQ ID NO:1329: SEQUENCE CHARACTERISTICS: LENGTH: 1314 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori- (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1. .1314 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1329 4 4044 *)4 44 4 4
ATAAGGAATG
TC!TGAGATTG
'ITGCATGAGG
GCAAGCTI'AA
AATITACAAG
TCATI'GGCTA
TTTTGCACGA
CAAGAAACAG
TTAATAACCG
GCCACTICGT
ITGATI'GATG
GCACGAGCGG
GCTGAAAAAA
GAAGCGAACG
GGTGATGTG
AAATACACCA
GTGGTCTTI'A
AGCCATAAGA
CCACCATGTT
CGGAGTI'AAA
G'FITIGTAGG
ACAATT1'AGA
GGGTTTCTI'A
AAAAAACAGG
GCT1'AAAAGA
GCTI'GCTCTT
TI'AATAAAAC
TAGCGGACTC
ATA'ITGCAGA
GTGAACAT(G
CCCAAAAAGC
ATATrCAAAC AAGAGCT1'AA
TCTACAATAT
AAAACAATCT
GTTGCCGTTI
TGGGAATAAG
AAAAGAAGTC
TATTAAAAAC
AGAACAAAGC
TTCTITGAAA
GGG3TGTGGGG
GGGCTTAGAG
GAATGCGGCT
GGGTCAAGAC
CCTCAACCAA
GCAAACCAAT
CAGAGGGTT
CACTAAAGAA
CAACACCCAC
ATCCACCGTA
CAATAACCGG
TTATGGCATG
AGGCAAATGG
CAGTTACAGC
AATCTCTATC
AATAAAGTCG
GTTCATTTTA
AGCCAAAATA
GAATACCATA
AACGCGCAAG
AAAAATGGCG
ATTGAATCGC
CGGAGCAATG
CTCTTAGCCC
GCGGTGGTGG
ATCGCTGTCG
GATATA'T
AAAAATAACA
GTGTrTGCG
GTCTTTGGTC
TATTATGAGG
TTCAAATCAG
AAAGCCI1T
TFTTAAAAG
AAGAAAACGC
?I'GACGGCGT
AAAATGATT
AAAGCATGCA
AAGAGCATI'C
TTTATGAAAA
AAATCACTCA
TAAACGCCGC
CTGATGAGGT
TGGTTAAAAG
CTATIGTAGG
TGATTGTCGC
GTCTGGCTAA
TCAATICCTT
GTGCGGGTAA
TCAAAAAGAT
AAATTTGTGC
CGGGAATCTT
AGAAAGCGTr
GCAGTATITT
G TrAAGACT
GTATITCCAT
TAATGAAGGA
GATGCAAAAC
AGTCATF1'CT
TATGAGGCC
GAGAAAGCTC
CATGCAACAA
CTCTAFI'AAG
GCAAGCCGCA
ACTCGATCAT
TGACATTACC
AGAAAACTFI'
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 GCTAACACTT CAGGCTATAG AGCITTTAGAA AGCCACCATG AATGATTTGG TTAAAGCCGT TCAAGAAGAT CACGTCACCG AAAGTGCATT TAATGGAAGA TAGCGCTAAG CATGTCAAAG TATGAAAAAC AAGATGAACT CAATAAAATC AT1'GAAAAAA
CGAGCGTGCA
ATTCAAAATA
AAALATATTGA
TTCAAAAAGG
TGCTGAAGCT
CCTAGAACAT
TAAGATG'Frr
CGAA
1140 1200 1260 1314 INFORMATION FOR SEQ ID NO:1330: i)SEQUENCE CHARACTERISTICS: LENGTH: 1032 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .1032 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1330 p.
V
GAGTGGI'AA
GGGTTGTTGG
ATTAAAGATT
GCTAATATI
TTTGTITGAAA.
TAGACGCTG
GGTAGCACTC
ACCAGAAAAC
GAAATTTAG
ACCGCAAGTT
ATGTI'AGTCG
TCACTCTCTA
AACGAGCTCA
AATATCGCTC
AAAACTCAAG
GAGTCTI'TGC
ACTAACGCTT
TGCTAAAAA
CCGTTCTI'GT
ATCGCCCCAG
ATGATAAGGA
GCCITCTAGC
TCATGCGCGC
TAACCCAACA
TCAAAGAAGC
AGCGTTATT
TAGGGTATT
CCI'ACCTAG
GGGCTAATGA
AATCCGCTCT
CCTATGTCGT
GCTATACCAT
GTITGGGCA
CTAATGATA.A
GATT1TITTAT
CGCTCAAGTT
TGTCGCT'CA
ATTTCGTTTT
GGTAGAAGAC
TATGATTAAA
ACTCGTTAAA
TATCATCTCC
GAACCAAACT
TAAAAAACCC
GGCTCCAAGT
TATITTTAAGG
CAATGAAGTG
GGATGAAGTG
AAAACTCACG
TCAAAAAATC
AGATGAAGAC
GGTTTTATCG
TGGGTAACTA
CAGATTTTAG
TATGCGCGT'
ACCCTCTITI'
AACGCTAAAA
AACATGGTGC
ATACGCAITG
TTTI'TTGGGC
CTTGACAAAC
TTTTATGC
CGGI'GTAT'
CCAATCGTCT
TTGAAGCAAT
ATAGATTTGG
TTAGAAAAAA
AACTTAAACG
TTTATITT
CGGATAAGGA
ACAGAAAAGG
TTGAAGAAAT
TTGAGCATGG
GTGGTCGTTA
TCACACGGGA
AAAAAGTCT
ATGGGTATI'A
TCACGCITAA
CTACCAAAAA
CTI'TAGGCTG
ATAACCAAAC
TGGATCAAT'
AITACCAACG
TCGCTAAAGA
CCCAGCATGA
GATTATCGTA
TATTGCTAAA
GCGTTTGATC
CCCCCCACGA
GGGGATCAAT
CACTGAAGGG
AAAXACCCTA
AAGCAAAGAA
TGGCGTGAA.A
AGAAATCACC
TTTAGAATT
GATTTCTTCT
TTCCACGCAA
AGACGGGITA
CTAGCGT'G
GAAGCCAAAA
TAGTTACAGA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1032 AACGAGCACC GG INFORMATION FOR SEQ ID NO:1331: SEQUENCE CHARACTERISTICS: LENGTH: 1779 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1779 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1331
S**S
S.
S S 555.
'S *5*S
S
.5
S
ATACGAACAC
AAAAGCTCAC
CCATCTCTGA
AAGCATACGC
CTGTTl'TAA
CAATTI'CTA
AATTI'TTI'G
ATCCCCCCCC
ATCAGTCTGT
GCAACAGTGC
GATAAACTTC
CAAAAGAACA
GAAACAAAAG
ACCATATATG
TrTATTATCC
AGCTCTACCC
AATAAATACT
CAAATCAAAT
CCTAATI'CAA
GCATTAGTCG
TATACCCCAA
CTAAATAGCT
TATAGCATI'G
AAAAGAGAA.A
AACACACTAT
ATAGCTACCA
AGCGCCATCG
TCTAAGATGG
ATCGTGTTAG
CAGGGATTAT
CAATGGATAC
CAAAATGTGT
ATATTCTTGT
ATITTGAATA
CGCATGTGTr
TAAATATCAT
AGAATAAAGA
TAAATTATGT
TTGGGATAT
CTTGTATTCT
AAGACCAAAA
AGGACAACCT
AATI'GTATCT
CTGATGTTT
TTTCAAAATT
AACAACAACT
TTGAAAATTA
TAGAAGAAAA
AACTTATTT
GCAAGAATGC
AT1'CAGGTCA
ACCATCAACA
ATGATAATCT
TACTAAAATC
TTGGAGCGCA
TGAGAGCCTT
ATCCCATrrAT CTTrAA'ITAT
ATCAAGGCAA
TTTGCGAATT
CATAAAAAGC
TGTGTI'GGCA
TATGATAAAA
CAGCTTGCTG
CTCAGGAATI'
CACTCAGCTI'
CCATACTATC
CAGTAATCTT
AFTTTCCATT
CATI'TCCAAC
AGAAAGCATG
ATTATI'AAC
CAATAATTTT
AATCACCACT
AAI'TGGTGTG
ACAAGATITA
TTTCTGTATI'
AATCCATAGC
TGAAAACTTT
TAGCGGAAAA
AATTATCATI'.
AATGAGTGCC
TITI'ATGCAA
TTITGATGAG
ATATAATGGG
TITAAAACCA
GGAAAAAGAG,
TACACACCGC
ACTAATAGAA
GTITTTGAAA
ATI'CCCATAA
TCAATTACAG
TTGATIGATA
TTACCAACTT
TTATCAAGCT
GCTAATAAAC
AAGCTT'AACA
TTITCAATC
AGTATTTATC
CATATAGCAA
CAAAATTACT
TICATGCTAA
GTGAAAGTAG
CTAAGTAT1G GGAGCAATrG
TCA'FITIATG
TTAGATTACA
ATTACATI'TG
AATCTCTCTI'
AGCACGCTGA
AATAACAAAT
ATATTTCAAG
AACAATATCA
AATFI'TCAAA
GTAGATITT
AGTAATI'GCA
TTTITAGArI' ATGAATAGT G
CAGGGCAACT
CAACAATAC
GAACTTITAT
TGCTATTTGT
TrCTGGTGAA
TACTACTATG
TGCAAACCAT
TCACACAAGT
CTATCCATAA
TACAACGCAT
TACCCTTTAT
AAAAACATAG
TATACTCTGG
ATTTTCACCA
CCCAAAAAAA
CACTATI
5
ITI
CTGGGTATAT
GAAAGTGGT'
AAATACCGAA
AAAATATI'AG
TACACTCTAA
T1'AATITAT'
ACCCATI'ACA
ATTTCTCT
CTAAAGAGCA
AITGTCTTAA
CTTTAGGTCA
'ITGTTI'AGA
TTATrTr1'AA
TCAAGCAAGC
TTGAAACCCT
TTI'ACTCTAT
CGGCATTCT
TCTAT1'ACAA
GGGAGCCT'G
TATTGCCGAA
TAAAAATCTA
CGGACTGCAC
TATAGGGCTI'
AATGATTT
TGCTTCCATA
ACTAGATAAC
TAAAFFI'ATT
CTTAATXIT
TCTAATGGT'
CCAAGCAITr
TTI
5
TGCTATC
ACCAGAAACA
TI'TCTCTTAT
TAAAATI'TAT
ATTAGGTTTT
AGACTT1GGAA
TTATGCTGGG
ATI'GAAGCAA
TGATTGCAAC
AAAGCAACGC
TGAGCCAAGC
AAAATCOCAA
TAATGAAATI'
TATGAAAAAA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1779 INFORMATION FOR SEQ ID NO:1332: SEQUENCE CHARACTERISTICS: LENGTH: 351 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc feature LOCATION 1 .351 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1332 ACGCCCAGCA TGATAGTTAC AGAAACGAGC ACCGGTAAGA ?TTTAGCCTr AGTGGGGGGG ATTGATTATA AAAAAACCGC TTTCAATCGC GCCACGCAAG CCAAACGGCA GITI'GGGAGC GCGATCAAGC CITTTGTGTA TCAAATCGCT TT1TGATAATG GCTATTCCAC CACTTCCAAA ATCCCTGATA CCGCGCGAAA TTTTGAAAAT GGCAATTATA GTAAAAACAG CGTGCAAAAC CACGCATGGC ACCCTAGCAA TI'ATACTCGC AAATTTAG GGCITGTAAC CTIGCAAGAA GCCT1'GAGCC ATTCGTI'AAA TCTGGCTACG ATTAATI' AG CGATCGCT1'G G INFORMATION FOR SEQ ID NO:1333: SEQUENCE CHARACTERISTICS: LENGTH: 444 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .444 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1333 240 300 351
C
CCC.
C
.C.C
CAAGGAGTTA
GTGCAATCCG
TI'AAGGATCA
TCGCAAGCGA
CAGGTIGCGG
GCGACTCAAG
ATCGT1'CGTT
AGCGTITAT'G
CAACAATGGC ITFCAGGTC CACTCACTCA AAACGCACTT ATAAAGCGGC TGATGACGCA GCAG?1'TGGG TCAAGCGATIT ATAAGGCTAT GGATGAGCAA CGGCTCAAGA TGGGCAAACT TGATI'CAAGG TTTGGATAAT TCTGGTCAAT TCAC
AATACAAATA
AAAACT1'CAT
TCAGGCATGA
CCCAACACGA
TTAAAAATCT
ACGGAATCTC
ATCGGTAACA
TCAATGCGAT
TGGAGCGATT
CGGTGGCGGA
ATGACGGCAT
TAGACACCGT
GTAAAGCGAT
CAACGACT'A
GAATGCGCAT
GAGTTCAGGT
TTCTI'GCGT
GGGGATTATC
TAAGGTI'AAA
TCAATCTGAC
TAACGGGCCA
owe..
C...a INFORMATION FOR SEQ ID NO:1334: SEQUENCE CHARACTERISTICS: LENGTH: 744 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .744 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1334 TTCAAGGTTT GGATAATATC GGTAACACAA CGACTITATAA CGGGCCAAGC GGTCAATTCA CTAACAAAGA ATTCCAAGTA GGGGCTITAI' CTAACCAAAG TCTATCGGCT CTACCACTTC CGATAAAATC GGTCAGG ITC GTATCGCTAC ATCACGGCTI CTGGGGATAT TAGCTI'GACT TAAACAAG TGGATGGCGT
GTI'ATTGTCT
CATAAGGCT
AGGCGCGT'A
GAATGATGTA
120 180 240
ACITTTAGAGA
GTGATCAATA
AGCGATGTGG
GGTAATATCG
GCGGTCACT
CGCAGTATAG
GCTrAACTA
GGAAGGTATT
CACGCTTGCT
GCGTAAAAGT
AAAACTCTAA
CGGTCCAGTC
CAGATATTAA
CAGAAACCGG
ATGGTCGTGG
AACGATGGTC
CTCGGACACG
TGCITCAGAG
TI'CTAGTTCA
CCGAACAGGG
AGGAAGTITG
GAAAAACGAC
TGTGGAAGCT
GATTGAAATC
AAAGAGCGGT
CCTAGACGTA
CTAT
GCAGGCACAG
GTTAAAGCT
AGTAATI'IAA
TCAGACGGAA
TATACGGATC
AAAATTGACA
CAAGATGAAA
AGAGCATCAA
GGATCGGCGT
ATGCGAGCGT
CCTTAAATGG
GGTTAGTCAC
AAAAAGGGCG
GCGTCAGTAA
CGAAGGGATC
TGTCGAITCG
GTTAGCAGAA
TATCACCACG
GATICXITI'G
AGCGATCAAT
CTTGAATF1'G
CGGGCCTAGT
TACTAACTAC
GTATI'TAAAT
0*
S
S.
S S S a.
*SS*
S
S.
S S INFORMATION FOR SEQ ID NO:133S: SEQUENCE CHARACTERISTICS: LENGTH: 390 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/K.EY: misc-feature LOCATION .390 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1335
TCACCTCTTI'
GCTATC'ITGC
GGGCA'ITCGC
ATCGCAGGGT
ATCGCGCTCT
GTGTrAAAAT
TTGGGCTTGT
GGTT1AAAAAC. ACGATTCCCA TTTGCGCGAT CGCTCATTCT CTTGGAGTAA CGCTTATGAG TTGTTTTACG ATCCAAACTC TTGTGGCTCA TrrAGGCTTT CCTA ITGGCT CAATATCCAT GTI'TTGTGCT AGGGATTTTA AATATTTGGc
GTGGGGCTAA
TCCATGCTCT
GCGCTATCGG
ATGGACCCTC
GTCTCTGTCA:
TCGCTAAAAT
TCTTGCGCTG
ATATCGCATG
CTI'CTAGCTr
AAATTGGCCC
TCACCGCTAG
CCTITATATG
GTATGTGAGT
GGCTTCTGTT
TTTGGCCGGT
ITTAGTGCCG
T^'ATGGC'TrT 120 180 240 300 360 390 INFORMATION FOR SEQ ID NO:1336: SEQUENCE CHARACTERISTICS: LENGTH: 1110 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .1110 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1336
AAAAGGCTI'G
AGCACCTTTA
ACCAT1TGAAXC
CAAATCGTAA
TTGATTAAGG_
GA.ATGCGAAG
AACGATAAAA
GATATTGCCA
GACGCTAAAA
CCGGCGAAA.A
CGTTTTTTAT
AITCTCAACG
GTCGCCTTGT
GAATITITGC
TTAAGGAAT
ACGATTAAAA
AAAGGCTTTA
GCCGGGGCGA
GGCGATGTGT
A.AATGGGCI'r
ACGCGCTCAC
CCAATAAAGC
AGCCTGAACG
GGGCGAGCAA
TGATCTTGCA
TIGACCCCCT
CTTTAGACAA
ATCTTTTAGA
CTTITCCCCTI'
CCCATAAAAA
AGCATGCCAA
GCGCTAAATI'
AAAGTTTGGG
TAGGCTTGAT
AAGGTI'CTAG
TTAGAGCTGA
AAGAAAAGGG
TGCATTTTCG
GTCTGTAGGC ATTGTGGGTT
CAAA.ACCCAA
CATTGTGAAT
AATCTI'GCAT
GGGGGAC-GGT
AGTGGTGCGC
AAATGATATA
AAGGATCGAT
ATGCGCTTTG
AAACACGAGC
AATGATCTAT
AAAAGTTGAA
GGAAGAAGAA
CGTAGAAGAA
CAATTATT
TGCGCCTGTG
AACCATCAGT
AGCGTTACGC
CTTCAATGTC
AACGCCCAAA
GTGCCTGACA
TCTGTGGTGG
TTAGGCAATC
TGTTTGAAG
GAAACCAITG
CGCTTGCAAA
AGTI'TAAAAA
GAGGCTITI
GTCGCTAATG
AACCATGCGA
ATGGTI'TCTA
AGCGCTAG
ACCGCTGGAG
GCTGCTGGGG
TATGACGATT
ATTGAAGGTA
TGCCTAATGT
GTGCGAATTA
GGCGGCT'GA
AATI'TTGGA
AGI'ITFTAGC
ATGACAATAT
AATTGGAATT
AAGCCCTAAA
CGCATrI'AGA
TGGAATI'AGA
TGGGCGAAGA
AAGTCCAAAA
TGAGTGGAGA
AAAAA~CCAT
TCAAGGAAGT
TGATCCATAA
TTATCGCTTA
AGGATTATAT
GGGCAAATCC
CCC1.FI rTGC
TGCGTTGGCT
TATTGCCGGA
CAATATCAAG
CACGCATGTG
GATTTTGGCG
AAGCTCAAAA
AGAATTGAAG
CAAGGAATTG
AGATTTAAAT
TAGCGAGTT
TGAAGTCAAA
TCGTI'TGAGT
GCGATCATGG
GGATTFI'GAA
TAAGGGCGAA
CGTTCAAGAT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1110 9 9t 59 S S .959
S
INFORMATION FOR SEQ ID NO:1337: SEQUENCE CHARACTERISTICS: LENGTH: 423 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NME/KEY: misc-feature LOCATION .423 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1337
AGGAATAAAA
CTAGGCGGCT
AAGTTTGTGC
TCTTTCATGT
TCCATGCAAG
GAAAACCCCA
TTGGTGCTT
GAA
CCATGCAAGC
AITI'GATGCA
CTTACGAAGC
ATAAATITGA
AAGAAATGCA
CTI'A1TTAGT
TGGGGCTTTG
GTTAAAATCA
TATAGCTATT
TGAAGGGATC
AAAACCTGCA
AGATAACCCT
GGCTGAAGGT
GATGCCITTA
TTGCTI'GAAG
TTCATCATTT
GCCCCTTTTG
TACAAACAAC
AAh.ATCGTTG
TTAGGGATTA
ATGGGCGTAG
TGATTACAAA.
TI'ATrI'GGAT
TGGCCAACTC
ACAAAATGTC
AAAACAAAGA
CGATCATGAT
TTGGGGGCTr
ACTCCAGAAT
TGGAGGGCTI'
CCCTTI'CTT
TGAATCCCAA
ATGGCATAAA
CCTAGGCATI'
CTTGTCGCTG
INFORMATION FOR SEQ ID NO:1338: SEQUENCE CHARACTERISTICS: LENGTH: 231 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE-- NAME/KEY: misc_feature LOCATION 1. .231 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1338 CGATCACCAC CCTAT'CTFI TTTAFI'CACA ACGCCAGAAG TG TTT GTCAA CCATGGCT CTGGGGCTGG AAGGCTAGTG GFI'AAAGACT TGGCGTI'ATI' TrGTl'TGTGG CCGGXTrGA TGCGAAACGC TA? TGGAGG GTAAAGGGT GACCGCTCAT CGGTAGGGAT TAAAACTAAA TGCTCTAGCG GGTGTTGCTC INFORMATION FOR SEQ ID NO:1339: SEQUENCE CHARACTERISTICS: LENGTH: 819 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .819 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1339
TCAGCATI'C
TGCTGGAGGC
TTGCTI'GATG
T
U
U
U U
U
U.
U. *U U U 4
U..
U
U.
U..
U U U.
U.
U
U
TGGTGrTI'TA
AAAAAAGATT
GATGGGCTI'G
TCAGACGGCT
TACCAACATG
ATCCGCATAG
ACCATACCCA
CCTATGTI'CT
GGGTTATTAA
AATATTAACA
GGGGTTGAAG
CGCCTITTC
GAGCTTTCTT
AGCGTTI'TAG
cAAATATTCA
TI'TCCAATTT
TGGTCGTCTT
CTAAAGCCGG
CTATAGCCCC
AAGAGCCCAA
AT'rAAGATG
ATCI'TATCAA
ATTCTCTTAA
TCGCTTTTAT
ATITCACGCT
ATMA.CACCCC
TAAAAAATGA
GCATGGGTGT
GGAAATCGGG
AGCCCAACAG
ACCGAGTAAA
CATGTGTGGG
TAAAGAGCAT
CATCGTAGAG
CAAAAAA.TT1'
TACAGGAGTG
CACACTGGAA
AGAAAA.TAAA
AGE LTGCGGG
TAAAAAAGCC
TGGAATTTT
TI-rrAAAAAT
AATGATTTIT
GTGTGCCATA
GATTATGACT
AATGCGAGCC
GTITTI'TAG
AGCAATCTCG
TTTACTAATA
CCTCATTTAG
Tl'AAGGGCTr
GAGACGAT
ACAGGCATGG
ACTCTCATCC
TATAAAGGAG
GGGTG I7171 TAATCCCTCA AAGTTTCAAA
GGCATGAGGG
ACGAATGGGA
GI'GCGTGGG
CCGGAAAA.AG
GTAAI'ATCA
ACAGCGTT
TGGGA'rITGT
TAAGGCATGA
TTTTACAAAC
CAGCGGTT
CTAAAAGCAA
TCGCGCGTTA
TIT1'GGGGCA
TTTTACAAT
GTTAITTTGCC
AGAGATTCT
AATCCTAGAC
AGAAAATATC
GAAAAATAAA
ATI'TAACGCT
TrATGAGAGA
TATCGCCGCG
CGAATTI'TTA
TATCGGCATG
120 180 240 300 360 420 480 540 600 660 720 780 819 INFORMATION FOR SEQ ID NO:1340: SEQUE NCE CHARACTERISTICS: LENGTH: 1077 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1 1077 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1340 eve eve.
eve.* 0. a
TTTTGGTTC
7TTTGATTG
ATCGCTGGGC
TCTAATGTI'A
TTGTATTI'A
TCAGCCTTAA
ATTCATGATG
TTTGAAAG
TTTATCTTGG
TTAGGGGTCT
ATITACGAA
GGGACGATGA
GCGTCTTI'GG
CTTTATCATG
GGTGTGTTGA
TITAAAACCA
TCTCAATTTG
TIACTGCGAT
AGI'ITAATGG
GTITTTATTG
'TTI'GTGTGT
TCAGTTCGTr
TTGITTATAA
TCAAATGGCT
GGGTI'AGCAA
TGAGCAGITA
GGTTATTGTT
TGCCTCTTGA
TCGTGCTI'T
TAATATGGT
TGCCGGCTGT
GGCATGTGAA
TI'GATAGCGT
CCCTI'AAAAT
GTI'TI'GGGG
TGTATGAAAA
GGATAAT'GC
GATGCTI'AT
GGGGCTTTTT
T'ITATGCGTT
GGGTTCTAAT
TAXAGGGACA
GTITTI'AGAA
TATTGGGAAA
TTI'CTIT'T
AATGAATCAA
AACTTCTCTC
TGGGCATGAT
TGGGGGGGCT
TGAGGCTT
GATCAAGCCA
CAATGAAATA
GATI'ATCGTA
'FrACTTrM-r
ATGAAAGCTC
CTGTATCAAG
CAAGTGAAAG
TTGG'FITTAG
GTCATITIG
ATCACCGAAA
AATITI'AGCG
TACAGCTTGA
TACTATGGGG
AGTAAAAAAA
ATCACGGTITA
GGCTGGTCTI
TTGATFI'GGA
VITTATCGFITT
ATITTAATCG
TTGATITTCT
GGGCCTACCA
CAAAAGGAGC
AGTATTTCT'
ATI=AAT
TTTTTGAA
CGAGCGTTGT
AAATCAATTT
ATrI'GTCGCA
CCGCTTCCAT
AACTCGTI'AC
AGAAATFA
TTT TTGAAGA TT TTAGAGGG
TAGGGATI'
TCCCTATAGC
TGTATTCCAT
TT =ATCAA
TTTCTATGAT
TCACGGCGT
AAAAAACATG
TTGGATCTT
GGACGCACTG
TAAACGCTTI'
GATCGTGCCG
TCAAAAACTI'
TITI'CCTGCC
CACGGGCTAT
AGACGCT'rrA
TCGTTATI'
AGTGGCTGGG
CGTGGCGTTT
ATACGGCCTA
GATITATGAG
TTTGTTAATT
AAAAAGAATC
TGCTGGGAT
TITTATCGCG
CGAATGT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1077 INFORMATION FOR SEQ ID NO:1341: SEQUENCE CHARACTERISTICS: LENGTH: 645 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .645 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1341
AGGTTAAACA
TTCTITTCTC
GAAAG'ITTCT
CCTACCGAAA
CCCAAAAGCG
GCTGTGATr
TGAACTACAA
AAAGTGAAGC
CTAAAGTCGG
CCTTTATGAC
CTACGGCTAA
ATGATAGCAC
AGTTGCATCT
TTTTGATITG
TTTCAATAAC
GATTATGGCT
CGGGCACCAT
TAAGGATTT
GCTAGAAATA TCGCAACGCT GGTAAAATCG CTAAAATCAA AAACCTATCA ACACTAATAA TACATGCAGG TGGATITTAC TTAGACGGGA GCC1TGGGGG ATTAACGAAG TTACAGGAAA
TCTTTTCTTIA
AGCGGGTGCT
AGGGATTTAC
GGAGCTCTTG
TIGGGGGGGT
ACCCTATGGG
GCTATGACGT
AGT1'GCGGGT
GAAATGACGC
GCCGATCACA
ATTI'TGAAA
GGAACTACGT
TAGCCACAGG
AGTTGTCTAA
CGAGAAACTA
TTAGGGGCGG
GGGCTAT1'GG
GAATTTGACC
TCAAGAAGCT
TGTGATTTAT
AAGGTACGAA
GGCGGTCTTG
CAAGGCCAAT
TTAGCGGCTT
AACGCTIACT
TCCCAGCGGA
TAGGGCAAAA
ACGATAAGAT
CCACTTGCGC
TGCGCTACAA
TI'ATA
ACCATGGGCT
GACTCAAGCT
AAAAACCTAT
CTACAAAGAT
INFORMATION FOR SEQ ID NO:1342: SEQUENCE CHARACTERISTICS: LENGTH: 795 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .795 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1342 a. p. p.
p p p p p ATTITCTATC CAAAT GGG TA GCTITAGGGC AAGTAGGGAA GCGGTTTGTr 'FFICCTCTCA CTCTTTIA TTTTAGGGGC CTCAACGCGC TTTITCTAA TC TTI'ATTGC TCCCTAAAAT TTTGTGGCGA GCGTGCGTT ATCI'GCACA CCGCTTTAAA CTGTFTTTAG GGCTTG 1IT17 AGGATCAAAA AAGCGCGTT TTGGAATTGG CTTTCAATTC GGGTITTATT ATITCTTGCA GGGGTGGATr TrI'A.AAAAT AAATTAGAAT TGGAT
TAATAATCGC
TATTGTTATA
AAGCGCTGAA
GTTI'TTATTA
AAGAGGGGTT
CTTGCTCCCC
GGGCTATIAC
AACCTrTGCG
AATGAAATT
ITTACTCGGG
GTIACTGCCC
ACAACAAGAA
CCTTTTATG
ATGGGTTTTIT
GGGAATTTCT
GAAACGACCA
GTCGCAATCA.
A.AGCTITI'1
ATGGTGTTT
CTI'TTTAACG
TTAAAACCCA
TIATTTGTTT
GGGTTGI'GT
TTAATGAGTT
TAAAAG7?TTT
TAATAACGCT
TGCTCACCCT
GCGTGGGAGC
CCI'ACCCAT
TTATCTTCAG
CGCAATCCAG
CTAAAACTAT
TGAGCGTTTT
TCATI'CTGGT
CTAG rTAG
AAAACATGAC
CACTGTI'TTA
AAGCTACACG
GATCAAAAAC
TAGrrI'GGAA
TTTGTI'CTGG
CGTGCTGITTT
AGGCGTTGCG
AAACGCTACT
GGGGGTTGTT
CATCAATGAG
TCTITTATGG
GCTCACGCAT
120 180 240 300 360 420 480 540 600 660 720 780 795 TIACAAGAAA ATAAATACTA TATGGGGTGA TCCGTTACI'I INFORMATION FOR SEQ ID NO:1343: SEQUENCE CHARACTERISTICS: LENGTH: 594 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: -circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORI.GINALSOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .594 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1343
CACATGAAAG
GAATCITATG
GAGGGCGTTT
GATTTTGAAA
GGCTTI'AA
AAAATAGAAT
AAAATCGCTC
ATGCTCATTA
ATCACGCAAA
TGTATTGA
GCTTATGGCT
TTITTTAACAA
CTAAAGAGCT
AAAATCCTAT
AGCAGCTCAA
TAGTGGCTAA
CCFI'ACTCCC
ACGGCTATTC
ATTTTAGCGC
CGCTTTTGGG
TGTAATCTCT
TCTAAGGGG
TI'ATCTTAAA
CGCTCTAGCG
ACCCCCT1TT
CCCTAAAGAT
CACAAACGCT
GGTCGCAGTA
TCCTAAGGGA
CGCGTTTG
TTAGTTI'TG
CGTTTAACAG
ACCGGCGTGC
AATAAAAAAG
GTGGTAT1'CT
TTGCTAGACA
AAAGAATACA
GATGCIAG
GTAACT'ITTG
GGGCTTI
TTGGTTTTTT
AA.AAAAGCGT
GTITTGCGAT
AGCGCCAAAG
TI'TTCTACCA
CTGATAAAAT
CGCCCCAAAG
CGGAAAAATA
TAAAGGTGGT
GTGGGCTAAT
TGCGTITATA.
TGATATGACG
CTATCAAGAG
TGACGCTCAA
CTTTI'GA.A
AAITTCAGCC
TCATGTGAAT
TAT1'TATATT
ATCT
120 180 240 300 360 420 480 540 594 INFORMATION FOR SEQ ID NO:1344: fi) SEQUENCE CHARACTERISTICS: LENGTH: 591 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacier pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .591 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1344
GAGGGAAAAT
TTrGGGCT'G
GATITAGTGT
ACTTATGAAA
AGCCCTAAAA
CAAGAAAACC
TTGCAACCGC
CCCAGCCAAT
TTAA).ATITG
GTTITTAAAA,
CAATGAAAGA
GGATCGTGGT
ATTTCAAGGG
ACTTTAAATC
CCCCCATTT
?I'TTAAACAA
TCAAACCCGC
CCCAGCCCAG
ATITGTTAGA
ATAAAGAAGA
AAAAAACTT
GTITTI'AGTG
TCATAACGAA
CAATTATCGT
GCCCTATTT
CGCTFI'GATT
'ITTAGATTCG
ATTAT1'AGGA TGGCC'TrAG
GTGTTI'GCCC
GTGGATTTAA
TITI'CAG TGG
TCTAAAGGCA
TTAGAAAPAGT
CCAAATATI'C
ACGCTTGATT
GAAiTCATGAG TAAAAATrC
ACTTTAACGC
GTTTAAAGCC
CGCATGGGGA
CCAACACGCT
AAGTGTATTT
GTAAAAACGC
ATAAGATCCT
CTTrTTTTAA
CGTGCTTAT'
GCCTAAAAAT
CATGCTI'AAA
TCTTACCGAA
TAAAAAAATC
T1'ATGCACAA
AGCGTTCTAT
ATGCGAACCT
TTTTAAATTT
G
120 180 240 300 360 420 480 540 591 GGGCGATAAA GTGGGGCGCT ATTGA'TI'TG GAGCAACTGG INFORMATION FOR SEQID NO:1345: Wi SEQUENCE CHARACTERISTICS: LENGTH: 1128 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAMEIKFX: misc_feature LOCATION .1128 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1345
GCAAATCAAT
AGGGA'TFTA
TTGACCTITA
CCTAAATI'CA
CCAAGCCACC
ACCATTGT'G
ATCGTGTTAG
CAAAATAACG
ATAGTGTCTG
AAAAACCCCT
TIATCCACGA
AGCATTITCA
TCTAAATACT
GCATTAGTGG
ATGGGCGATA
CATAATGAAA
ATCTI'GCAAG
CATCATCATT
A'FITCTATGC
TI'GCGCTACA
TGCTCTAITC
GAGCAGGGT1'
TI'CTATGGGC
AGAATAAAAA
CGAGCGTGI!
TGGGCTTTAG
CCGGGATGAG
TTTATTGAG
TGTTTGAAAT
GCAATGCGGT
CCCTCTI'AAG
TGCTCTATCC
GATCGCTCTT
GCGGGAGFFI'
TCT1'GCTCGT
TAGGGAGCTA
TTGAACAAAA
TGAGTAATI'
ATTITCCTTT
TITATTATAT
AGGGTTTTTC
CAAGGCTAAA
GGATACCCCT
GTGCGCGTCT
TITTTGTGGGT
TGCGAAAATG
CCTI'AAGGGG
GCCCACGATG
GAATTTAACC
CCTTTCTATC
TAAAGTCATA
TGGCTTITTG
GGCAATAGGA
TTTAATGGGG
TAAAACCCGT
GGGTTGGGCA
AGTCGCTCTT
TCTAATTI'CA
GGCTATI'TTA
ATAGCCTITT
AAGGCTAACC
ACGATGGGGG
TTGAGCAATC
TI'TAGAGACG
AAATTTGGCA
TTGGACACT
TAGCGGTTG
GACGGGT1'AG
TTTGTGTATG
GATGTGGGGG
TGGTATAACT
GGGTTTATCG
TCTATTTIG
AAAAAACGCC
GAAAATAAGG
TTGAGCTI'GA
AGCATGGCGA
ATATCAATCT
T1TCTCACGCT
AGCCCAT'TC
GCATTGTGTT
TTI'ATGTGT'
ATTACACTAA
TGCTGTI'TAT
TTTTATACGC
GTTTIGGGT
ACGGATTAGC
TGGCAGGGAA
AAT1'GTFIGT
GCAACCCGGC
CTI'ATAACGC
TAATAGAAAC
TTTTI'AAT
TGATCGTGCG
AGGTGTGT
TTTTACCACA
TrI'CCAGTAT 7TrrAATG
TAGCTTCGTG
TGTIT1GCA
GTTAGGGATA
AATCAACCAG
CCTF1'CGCTI'
GCCGTTITG
GTTGGTTITT
GAGTGTGCCT
TGCGGAATIT
GAITTTCGCTA
AAGCGTGT
TATTGTTICG
TCTGTCTGTG
GGCACCCATC
TTTTTGGATC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1128 S S S S. S 55** S. S 5
S
INFORMATION FOR SEQ ID NO:1346: SEQUENCE CHARACTERISTICS: LENGTH: 909 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NiAE/KEY: misc-feature LOCATION .909 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1346
GCAAGATTTA
ACTrI'GGGTA
AATGGGGGGA
ATGCTITTTAG
CAAATCTI'AG
GGCCCTCTCA
GTAGTAACT
CAAAATGGCA
TGGTTTGTI
TI'ATTGTITG
AAAGCTTTGC
GACGCTII'1AG
TAAAATATT
GCTCTATCGG
GCGCGTTTGT
TGGAAATGCT
ATCCTAAAAG
TTCTATCTI'
TTGAITrGCC
GTTTGATCTG
CTAGGGGGAT
TGATTCAT
G71"'TTTATT
GGCAGATGTT
TGGCATGGGA AAATTCTA AATTAGGCT1'
TITAGGGCAT
GCTrITATAC GAT1'GGAAAT
GAAAAAATAT
'TATGCGGTG
TAAAGATITA
GCCTGT'AT'
TGAAGAGGGG
AGGGCTTITA
TAATTITGAG
Tri" CTTTG ATTTGGCGCT TTCCTTATAT CTAGCACTAA CCTI'GAGTTT1 TTGGGTAAAA AAGACGTTGT TACCCTTCA CTTCTFTT GTGT1AGGCT GGGTGCTI-rA GAGCAGGCTA AAATGCAATT GGC TTAGCG CATGCT1G= ATTGAAAAAT TAAATGTCGT ATCTATGCGA TGACITTAGA ATTCAAAAGA 'rIGATITTAA AGTITAGGGG TAGGCACGAT TAT TTAGCC
GGTAGGTCAT
AGGCATTGCT
TTCCAATI'AT
TATITI'AGGC
CTATCTF1'T
CAGCATGCTI'
GCCGACAATA
GCTGATGCCC
AAGCATGCCT
GGTTGTGATG
CATTACTTAT
120 180 240 300 360 420 480 540 600 660 720 TCGGC7ITTTA CGCCTAAAAA AGAAAACCTA CTCAAAAGCT GGTATITTT AA TI'ICTTTGAT TGCCGGGGTG ATGATTTITA GCAGACGTGT CTCAAGGGCC AGGGCTTGTT TI'TA FFI'CCT
ATGGGATCA
CTCTGTTTAT TGT-IACCc CCTFTGTGTr TGAATACCAT TACCTrAAC 'ITTCGCTAAA INFORMATION FOR SEQ ID NO:1347: SEQUENCE CHARACTERISTICS: LENGTH: 1278 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (iX) FEATURE: NAME/KEY: misc-feature LOCATION 1278 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1347 a S 5555
S
*5 55
S
S S *5 S. S
S.
S S
S
AGGTGTGTI'A
CG7rrrI'TTA
TTIAAGGATA
CAACTAGAAA
CATFI'AATGA
ATGATAAGTA
'FTAGAAGATT
GAAAAACGAT
AAGGCTI'ACC
TGCAA2T"TG
TCGCTCGCTA
CAAAAAATCT
GCCCTrTFI'
CAATTAA
CTGAACGCTT
TTGTGGGTAG
TTAAAAACC
CCCCTTITG
TCTATCATAC
GAAAAAGCGG
CCTAGCGCGG
GCGTTGII
AAATGAAAAT
AAAAAMA.CCA
GCGAGGGTTI
TCGTCAGCCC
GCGAATACGA
TTAGCGGCAC
TTAAGGCTGT
CGCCCTTGTG
CTTTAATCTA
AAAATTAI'T
TCCTCCCT1T
T'.LI'GACAA
TTAAGGGAGC
AAATAAAGAA
TTAAAATCGG
ATGACAGCAA
AAAAAATCCA
AAGAGTTTAA
AAGCCTTAGC
TI'CAAGAAAT
CCAGTTTGGA
TAAAAGAT
TTCTFI'AFIG
TAATGAAGTC
TCTTTGCTAC
TGGCAFI'AGT
TTATATTGAT
TAACGGGAAA
GAGTGGGGGG
GGTGCTAGAA
CTI'GCTCATC
GAACGCTAAA
AAAATTCAAA
AAGCGAAGAG
GTTTATTA
TITAAAATGG
CTCGCATAAA
AGCCACGAAT
TTTGATrA
AAACTATAAA
GTTAGAATTT
TAAAAGCGTT
TCAATTCT
GGGCATGGAA
AAATITITTG
CCTAGTAAGG
TITCACGCACC
AGTrI'GTTTG
ACCACCACQA
AATATCGGCA
ACAAGCTCCT
AATGTGGAAG
CTCAAGGTT
GAACACCCTA
GTTTTAGAGT
GACGCGGCI'
CAAGATTATA
ATGGAAGAAT
AAACCACTCT
ATGATAA.AIT
A TTTAACCC
CTITAGTCAT
ATCATI'CTT
CCGAAATGCT
CGCCCTITGAT
TFI'CTTI'GCA
CCGATCAT
TAACATTGAT
TTGTTCAAAA
GTAAAAAT
TAGCCCTIT'
GAGAAAACGC
7TAGGGATAA
AGCCCTAGGG
CCCTGCAT
TAATGATI'CC
GAAAGCCAAG
CACGCCTACG
CACCACACTT
TGAAITGITI'
TTACACTAAT
GACTTGGCAT
GCCTAAAACT
CTCGCAAGCG
CCCTTCTAAC
AGTTTATGAG
CCTTAAAAGA
ACAAGGGCGT
CCTAAAAACC
CAATTTAACC
ATCAAGCGCT
TTTGAAGTTA
TTT'GCTITCA
AAAAT1'CAAA 120 180 240 300 360 420 480 S4 0 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1278 ATI'GATGCCA CCTI'ACAAGC GGGGGCGATA TAAAGGGGT ATAAGCCTrT ATGCCATAGG AATGTFTCT' GTCAGGTI'G TTATI'ACAAA ATGAAGTCGC TCGTATAAAG AAAGGGGTGA INFORMATION FOR SEQ ID NO:1348: SEQUENCE CHARACTERISTICS: LENGTH: 810 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .810 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1348 GATATGGGTA ATCATTI'C GG TITTAGGGC ATATCTGGCG GTrI'TATI'GT TTITATTTTT CTATTAGGAC AAAGCACGCA CCTAAAAAAC GCTGGAAATA TT~TTATGGCA CTATITIAGG CCTAGCAGTA TCCAAGAATC CAATCCATAG GGCTI TTAG AAAGAAGGCA TTGAAAAACT GGTTGCTI'T ITI'ATGCGAT GA'FITCAAGC CAAAAGA TI' 7TTCTCTAA GTATCGGTT CAGAATTTGC TTAAAAGCAC
TAAAI'AGGA
CTTCCCCTAT.
ATCCITAAGC
AAAAAATGTA
CGCAGGGATC
T"IGGGTGCTT
TGAACAAATT
CGTTATTC
CAATITGGT'
GAGCATGGAT
GACCTCTCAA
AGGGATCAAT
GATTTGGGTG
TTTGTTT1TAG
ATGACTGGGG
GTTGGTGCGG
ACAGAAGCT1'
ATGCTTATTT
TATTATTTGG
T11'ACTCAAA
ATAACCGGAT
TI'AATGCCCT
TCTTITICTA
GTGTTCACTI'
ATCACITATG
GTTTTATCAG
CGGCTTTAGG
TGAGTGGTGG
CGATGTITAT
TTAAAGAGCT
CTGGACCTT
TGAGTATTAG
C TTGCAGTC GGATrGI'rrC
TACTCI'TGC
AAGCTITCCA
ATTCCTI'GGG
CTGCCGTTAC
GGATITTAAT
GAGCGCGATA
GGGTGCTTTI
CGCTGAAATG
TGACATTAAC
AATACTGACT
TTTTAATTTG
TATAGGGTI'A
TAGGGGGATT
CACTITITI
TTTCATGTrT
GCAGGTITIC
GGATAAAACG
TTCTC'rTGTG 120 180 240 300 360 420 480 540 600 660 720 780 810 9 9 9* *9 9 .9 99*9 9 GGCAGGGCTI ATGATITTTCA C'TTrGTGTT INFORMATION FOR SEQ ID NO:1349: SEQUENCE CHARACTERISTICS: LENGTH: 186 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) 99* 9. 9 9*9e 9* *9 9 9.
9*99 .00.
(iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscjfeature LOCATION .186 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1349 TGTCTCACAA GGCACAGGGT TAATCITCAC TTCTTTACCG GTGGTTITG GCCAAATGGG AGCGATAGGC GTI'CTTGTIT CAATTCII CTI'GCTCGCG CTCGCTTG CTGGCATCAC TTCTACGGTG CC TITA'ITAG AGCCAAGCGT GATGTATCTT ACCGAAAAGT ATCAATACTC
TCGTT
INFORMATION FOR SEQ ID NO:1350: SEQUENCE CHARACTERISTICS: L~ENGTH: 561 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular 120 180 186 (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Melicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .561 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1350 TTTCTCTI'GT GGGCAGGGCT TATGATTI'C
TCACAAGGCA
ATAGGCGITC
ACGGTGGCTT
TTAAGGTTA
TCGCTCCATA
TTGGATITG
ATGGGCTGGG
AAATTGITTG
A'TI'GGTI'GA
CAGGGTTAAT
rTGTFI'CAAT
TATTAGACCC
CTTGGGGTCT
AGGATI'ATAA
CATCAAGCAC
TTTTGAAAAA
CAACTTGGTA
GCAAGATTTA
CTI'CACTTCT
TCTTTTCT1'G
AAGCGTGATG
TGTAGCGTI'A
AGACTATCTC
CATTATCATG
AGAAAAATTG
TTTCTTGCTT
ACIITTGTCT
TACCGGTGG
CTCGCGCTCG
TATCTTACCG
ATCTI' GTGG
ACTI'TCTTTG
CCITTAGGCG
CGTCT=ITA
AAATACATCA
TTGAATATGG
TTITGGCCA
CTI'TGCTGG
AAAAGTATCA
TAGGCGTGGT
AAAAAAGTCT
GGATGGCAAC
GCGCGCACTI
CCCCTTTAAT
GGCTAATGTC
AATGGGAGCG
CATCACTI'CT
ATACTCTCGT
GTTGATFFI'C
TITTGATTGG
CTTATrTr
'FFTAGGCCCT
TGTGTT'CC
120 180 240 300 360 420 480 540 561 *eel 0, 0 *0 *00*t 0000 00 INFORMATION FOR SEQ ID NO:1351: SEQUENCE CHARACTERISTICS: LENGTH: 855 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY misc-feature LOCATION .855 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1351 GAGTCT TI' A TGGGGTGITC G TGCTFI'GG GGC'TrTCAAG AAAAAACCAA ATGACGCCAA AGTI'CTGAAC ATGITACGCC CAAAACCATC ATGTTGTAGG CCCTATATTG ATAAG TTT CA AGAGGCTATC AAGTGTI'GCG AAGATFFTT CCGTFITGGA AA TTAAAAG ATCCCAATAG GTATGG TTA ATITI1'ATGA GTAGGAACIT T1'CAGGCAAT ~AATITC CAAAAAGCGT CACAAGATIT TAAACAGAAT AAAGAAAATA TCGCCAAATA ATGCCTCAAA AAAAG
GTTATCTI'
CGTGTTGATC
AAACCAACAA
ACTAGATT
TAmTTAATG
AGACGCTFI'A
TITTCAAGAT
ITTGAAAGGG
TCCCAATrrA
ACCAGAAAGC
AACATACACA
TATCCATGAA
GTATGCGGTT
CAGAGACGCT
AAAAXAGTTA
GGT1'GCGCGA
CCAGTTCAAA
AATTACCCGG
CCACGCATTC
ATI'AATCAAA
GAAAAAGCTIT
TGGGTAGGAA
GACACGCTAG
AATCGTGTCG
TACACCTCTA
AATI'TGGATA
GGGTTTAT'C
TGAATCCAAG
CTCATGAAAG
TGCATATTGT
AAGTGAGCGA
TCCAAACTAT
TGAATGTGCA
TCTAGAAGA
TGGATCAAAG
TCCATGATT
CTAATAACGC
AGAATAGAGA
TAAAATGT'G
CGCTGAGACA
AATGACAACA
TCAAGCCCCA
TAATCTAAAA
TTTGAAAAA
AGATAAGAAA
TTGAAAATG
CTCAGGCTCT
TGCTGTAGAA
TTCAGGAGGG
AGACGCCATA
AGA.ACTI'ACA
TAAAAGTTCT
120 180 240 300 360 420 480 540 600 660 720 780 840 855 GTCATGAAAA AAGCTGTAAC ATI'GATAGAA TGAAAGGCTI' INFORMATION FOR SEQ ID NO:1352: SEQUENCE CHARACTERISTICS- LENGTH: 1053 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc feature LOCATION .1053 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1352 0s@* 0S S *5*e
S
S.
S
S. S S
S
50.0 Oq S.
S.
S. 5555 SW. I 0
OS..
9* S S
S
GAATTGGTT
CCAGAAGTCA
ATTITAATCC
AGCCTTATGC
TAAATGAAA
GGGACGGGAA
CTTACCAGAT
TATGTGATT
CAAATCCCCT
AAATACCCCT
TTAAGCAGCG
ATGGTGAGCG
AGCGCACACA
TCCCCTACAA
AATATCITAG
GTCCCCAA
GCTAAAGCCT
GGGAAACGAT
TGTTTGAAAA
ATTTAAATIC
AATI'GCTCGT
AAGCTTTCTT
GCCAGTI'TGG
TTATTGcTI'
TGATTAAGGA
GTI'ACCATAA
'ITGTGGTCGT
ACTATATCAT
CTAGGGGCGT
TGCGCTTGTT
GCGATGAAGG
AACTCATGGC
AGCG7=rIAT
CCAGCTGCCT
TTGTGATG
TATI'GCAAGc
GTGAAXT
TGAAATCTAT
GCTTITAGGC
TCAAACGACT,
GCCTATAAGT
TAGCGTGGCT
GAAAGGTATG
TGAATACACC
GGATAATGAT
AGGCGATCCG
TGTGGCGTTG
TGAAAAGGAA
TTTIAGAAApA
GCAGAGAGTG
CAACAAAA
TGTGT1'AAGG
TATCACTCAA
GAATCCAAC
TTTAAAATCA
GAGCA).TT1'A
ACTCTGGGAT
TACACCATGA,
ATTTTIT A ATrrITAGTTA
ATTTATAAAA
ATI'GAGTTCA
CCTAATTTTG
CACACCAAT
TCTAAGATT
TI'AAAACGCA
TTAAAAAAAT
AGCGCGAG
GACACGCT
AAATTAAAAG
AAAGATGGCA
TAT
AAAAAGACGA
AGGTCTITTAG
ACTTC!GCCCT
CAGCTACAOG
CTTCCATT
GCGTGGTCAA
TCGCGCGCCT
GCAAGCAGTT
AAGAAGAAGC
TAGCCATGCT
TACCGGTGAA
AACCTTACTA
TAGGGGCTGA
CGGTGCGTCC
TAGACTTAGA
AAGCCCArrI' AATACATccc
TGAAAATCAG
ACTCCCGCTT
AGAAAA'ITAT
GTTTGGCGCT
AATIGTFITGT
TAAAGGCACG
TAAGGATCAT
TCGCTCCGCT
CAI'AAGCAC
AAAAACCCAC
CGTCGCGTTA
CATCATTGCG
TATGGTGGTT
GGATATGGA.A
GGAAGTGATT~
TAGAGAGATC
CATGCCTGAC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1053 INFORMATION FOR SEQ ID NO:1353: SEQUENCE CHARACTERISTICS: LENGTH: 315 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: -DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: No (Vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feattire LOCATION .315 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1353
ACCAAAAAGT
AAAATCATTT
ATGCCTATI'
TATAGAAGCA
GGGGGGGTTG
ATGCCACGCT
TAAACAATAC
TITTGTGCGT
TGCGCAATAA
TCATI'AACCG
GCGCTGTAGA
CAATT
TCTATTCAAT
L rTGATA
AACCCCCAAA
CCAAAAGCTC
AGCCATTAAG
AAAGGATTAA
GGGGGATITG
AAAAATTACC
ACGCGTAAAA
GACTATCAAG
TTATITI'TAA
TCATI'CCACC
AAGAAGCCCA
AAAGCGGGTG
GCAAGGAAAT
AATGTTTAAA
CCTI'GAAGCC
TGAAAAGCTC
GTATTTTTTA
GAAAGATTGG
S
A. 9 9 A. A A
A
.9
A
INFORMATION FOR SEQ ID NO:1354: 1i) SEQUENCE CHARACTERISTICS: LENGTH: 261 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .261 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1354 ATCATGGCGT GTAAATITTG GCCGC TTT AG GCTITTATTC ACTCCAAAAT CTI'CACGCCC GAAGAAAGGA AAAAGCGTrr AAGGCATGCG AAGAGGTITrr CCCTAAGATC AGAAAAACAG AGTTAATAAG CTAGGGTATG TCTTTCACGC CCTAT1'GAAA TATAGAGTI'G CAAAAAGCAT
T
ATTGGATTT'
CGCCCAAATT
AGCCTAACAA
GCTTACTTCA
TATITTTAATC
CAATACCCCC
TATGACTGAA
TAAAGACAAA
INFORMATION FOR SEQ ID NO:1355: SEQUENCE CHARACTERISTICS: LENGTH: 519 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: WA NAME/KEY: misc-feature LOCATION 1. 519 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1355 CGAGCTATCA CA.ACAAATCA ATTCGTAGGA ACAAACATGT ITrTAAAAC T1'ATCAAAAA TTACTGGGCG CGAGCTGTIT GGCGCTGTAT TIAGTGGGCT GTGGGAATGG TGGTGGCGGT 120 GAATCGCCGG TTGAGATGAT GATAGCATTA CTATTCAAGG CCAGTAAGTG AGACGTI'TCA GATTTITAAAG ATATGGCAAG ATAGCAAATA AAAFFICTCA AATITITGGAG AAAGTTTAAA CAAACCGACA AAGGCGCTTG
TGCAAATAGC
CGTGAAGCTT
AATGGGTGTI'
CACTTATAAG
AITAGAGCAA
AGGCAITTCT
GACT LTTAAC
GAGGGTACGT
AATAGAGGTA
TI'AAGTCAAG
ATAITGATC
AAGGGTGTGA
CAAGGGTGCA
TTGATAAA
F1'CAAATcGA
ATI'GTGCTGT
TI'ACTCCAAT
AAAAGAAAGG
TGATGGAAcc
ATATTATAGA
CTCCAAAGCA
CAATTTTGTT
CTCTATACAG
GTTGGCAAAC
TCAAACCCTT
GGCAGAAATA
a a. c a. a.
a a *aa.
a a.
C 0 0 INFORMATION FOR SEQ ID, NO:1356: SEQUENCE CHARACTERISTICS: LENGTH: 432 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAM~E/KEY: misc-feature LOCATION 1 .432 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1356
ATATCAAACA.
ATCTTGCAAG
CTCGCTCTCG
TTATGCGTTT
CAAGAAAGGC
GAAAGGCTGT
GCCATGCGTT
GGTITTGTT
TGGAAAATAC
GCGTTATCAA
CTGTGGGTGT
TAGGGGTGTT
TGTTTAGGGA
TTGAAGTCT'
CG'rrTAGTCT
CT
CCCGAAAGAC
CAGAATGGCA
CTTATCCCTC
G'rrAGCATGT
GCAATACCAA
CCCTATrCAT
ITTCCCCTAT
AGAGCAAGA1A CAAAATrCTT
AAAATAGAGG
TTITATCTT
TGGCTAATAA
CAAACTTGCC
TGGGCGTTAG
TCCTATAGA
TAGAATGCAA
CAATTI'CTAA
TAGACGCTI'A
AAAACCGACT
AATCAACGCA
GTTrGTGrT AGAGCrI'AAA
AAAATGGACT
TI!IT1ATGGG
ITATCTCATG
TAAAACCGAT
ATTCTTATCC
GGTGGGCTAT
120 180 240 300 360 420 432 INFORMATION FOR SEQ ID NO:1357: SEQUENCE CHARACTERISTICS: LENGTH: 966 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: Ne (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .966 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:13S7 CCC CIAAAT
TI'GGTTAAAG
AAAAAATTCG
TATCTTAATG
CTCGCTTCGC
TTAGGCGATG
ATGGTGAGAG
ACATGCAAGA
CATCAGGGCT
TFI'GAAAAAA
CAGTG'FFTAA
TGCTATTCTG
AAATACAAGC
GAAGCGAGTT
GAACGCCT'G
AAAACGATTA
CTCTCT
CAAAGGCAAG
GGGTAACTT
CITCATI'AGA
AGTCTI'GCTC
TCFI'CCCTAA
TTGCAAGCGC
ACACITFTTl-.C
ATTTTAA).AT
TTAACATGGG
TCGCTTTAGA
TCA.ATATGGT
ATTI TICAA
CGTGGCGTTC
TFI'GGCTCGC
AAATGGCTAA
GGGATI'ATFI'
CAAACTITTrA.
AGAGCAGCAA
GTTTATAGAC
CAAGCGTI'AT
TIATICTAAA
TTATTTTGCG
CCACCTTCCT
TGATCTTTTG
CTrTTGGTG GTrTITrGAAA
GTTTTFTAGAG
AGAGCACTAC
TGTCAGTTCT
CAACCTTTTr
AGACCAACAA
TIATTAGG
GGCGCTAACA
AACAAGCTT
ATCAATTCGC
GGCGGGCTTC
ATCAITTCCA
CTGGATAATG
TTTGAAGCCT
CGCTTI'AGCC
GCGAATI'TAG
ACTAGGGGAA
CGTATITI'AG
CCTAAAAGTA
TTGAACGGGC
TGCACCCCTT
ATGCAATCTIT
ATAAAAAATA
TCGTGTATAA
TAAAAACCAT
TAGATTATTC
TTG7rrTGTG
TAGATGTGGA
AACCCACTAA
TTTGTGATI
AAAACGAATr
ATTIATGGCG
AGGATCT='I
AATTGCCTAT
TCATCATGCT
GTITGA TTG
TTAAAAACGA
TTAAA.ACCCA.
AATCCATI'GT
TGAGCCTIITI'
CATAGAAAC
CCGGCTCTTG
TACGGTGTTI
ATTGCTTGGC
TTGCGAACGC
AAAACGCATC
CGAAAATGGG
CTACCCTGAG
TCATI'ATAAT
CCATI'TCATC
CTATGAAGCT
~Trl'I=AAA
CATCCGATCA
AG'TTTCGAA
INFORMATION FOR SEQ ID NO:1358: SEQUENCE CHARACTERISTICS: LENGTH: 1698 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1698 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1358 a AAAAAGT1T
GCCAGTAGCG
AACGCTTACA
ATCGGGTT
TTAGAATGGC
TTTATGTTTA
TCTGAAACGA
ITGATCGCTT
ATAGCGAGCG
CTTACAAAGA
IT.rATrCCG
TTAAATAATC
GTCT1'AGTCA
CCTAATAATC
AACCTCT'CG
AGCCTGCTCA
ATAGATATr
GAATGGGGGA
GGAAACTATG
CAATTAAAAA
GATCGTrTCC
CATGCAAGCA
AACGACTITG
CGAACTCTCT TAAAGGACAA TAACTCTAGA TGAAAAATT AAAATAGCGA TFI'GTITICT TGGTGTAITA TGGTTGCGCG TGTTrATAGG AAGCGGTATI' AAATGCCTTI' TTCCAAAGGC TGGCGTITAT AAAAAGCTAT
TG'ITGATCGC
FT1'rAGGGCT
ACGATGCGAT
CT'rATITGAG
TTTATTTACC
TCGGCGAAAG
CCTTATGCGA
TGIT"ITCTGA
ATTATAGCGA
TCAAGCGATC
TCACACAAAA
GTGCATACGA
GCAAGAATT
CTAAAAGCTT
GCGATAGAGA
TTTGAATGG
CATI'AAAATC
TTCTATCCT
TrI'AAAAAGA
TFTGTTTGAT
AAGCGATTAT
CGCGAGCAGA
GCGAACTCGC
CACGATAAGC
TCCTGAAACG
CCATTATGAA
TCTAGTCTCT
TGAAGAGCTA
TATCGTGTI'C
TGCCAAATI'C
CAAGCAAATC
AAT"ITFAAC
AAAAAAACGA
TTAATGT'CC
TI'CTCTAAAG
CTAATCCCTA
A TITAGCG T1'GAI'GACA
AAAAA'ITATT
ATTCGCTITA
ACAATAGGGA
TCACTCTTI'
CGCCAACAAG
CTTTCTAGCA
AATF1'CATGC
CAAGCGAGAG
AAAGAAGCCC
ACTAAACCTT
ACTTTTTGGT
AATCGTTCTA
GTGAAATTT
CATITTGCTTG
AAACCAAGCG
GTCGCTGAPT
CTCTFI'AAAG
TGAAA'=r TI'CF1TGCAA GCTrI'TTAGG
AAAAACGCTT
TGGCAGAAAT
CGCTITI'AGC
TGCTFI'ACTA
GAGCGCTTGT
GCG?1'CGTAA.
CTCTrCT TT
CCATAAAATI'
CGGGCGATAT
AACTCTATGG
ACAGAGAGAG
ACACCTCTGA
GGTATCATI'A
TAGAAAAACA
AAAACCGCTA
ATTCTAA.AAA
GCTCTCA?1'C ATI'rGTCTTr
ATGTCAAT'C!
ATAAAGACC
AAAATTCITT
CGCTCTTTCT
CGCTTTTTTA
GAAATATTCA
TTTTACGCTG
CACAAACAGC
CGCTI'TGATT
GCCTGGTGTG
CATTAAACAC
AGCTAGGGGG
rrATAGCTrT
TI'CAAATGTC
CTATAGCGTT
AGAGAGTAAC
TGTCTrI'GAA
CCACAACATG
AATCGTCGAT
CTATATTTTG
TGTCCAACCC
TTGGTATGCC
'DTCTAATITG
GCTITATI'AT
TATTGTGTTT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380
TATI'TGAGCG
TCTAAAGCGC
CACCCCGAGA
TTAATCCT
AACCTITI'TA
AATTATGATA
ACCATGCGCA
GATTAGAAAT
AAGTGAAGTT
CTCTTTTGCC
GCCCCCAATr
GGACTAAA
AGATATTTI
CCCTTTTATG
GATTAAAAAC
TTTGGTGGGC
TGACGCCCAA
GAAAGCGGCC
AT?1'ATGTGA
GCTTTAAACA
A ETCACACTA
AGAAAAAGGG
CTACTIATGG
GCGATATT1T
AACCTTI'CAT
AAGATGAAAT
CTGTI'TGTTA
GCATAGCTGT
TAAAGAAAAA
GAGCGATGAT
AGAGAGTAAA
TGGCAGCATG
1440 1500 1560 1620 1680 1698 INFORMATION FOR SEQ ID NO:1359: SEQUENCE CHARACTERISTICS: LENGTH: 222 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .222 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1359 p p p p p p p PC AAATC7I= A TGCCACCCAC ACGCCCCCAA GCGAGTATIT CCTTGAGCA TGCTATCTCG TT 4 TCGCTC TGTCTG'FrGA ACATCAAACA GCGCACCAAA. AGCATGCTrG ATTOCGOCT TF1'ATATI'AA ATACCCTAAA GATI'CGCAGC CTTTTAAAG.C TAAGGCTAAC CCTAAAAAAC AAAAAACGCG C'ITGCAAACA TATI'GAAGAA ATCAAAGCCC
CA
p INFORMATION FOR SEQ ID NO:1360: SEQUENCE CHARACTERISTICS: LENGTH: 255 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: -Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .255 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1360
ACTTCCGCAT
AAATTCCGCC
TATCAAATGG
CAATI'11'AG
GAAGAAATCT
CAAGGGTGGC TAAAGACATC ATCAGCG.AGT CTCAAAACCT GITI'GTATGC GTTATTGAAA GAAAATGAAA TGCTCATI'CG GGAACGATAA AGAGCTI'GAT GAAGCGATTA AGAAAAAGGC TGCAAGATGA AAACGCTTTA CAGCCTIIG AACAAAGCTT
TAAGA
TTGCGCAAGA
CATCGGATCT
TCTAATGGAG
TCAGCAA?1'A INFORMATION FOR SEQ ID NO:1361: SEQUENCE CHARACTERISTICS: LENGTH: 279 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .279 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1361 *5 S S 55 S S
S
B
*5 S
S
S
GATAAAAGGA
ACTTTGATGA
AT= FCAAG
GCCGTGATI'G
ACCAAAACCT
ATATCATGGA
TTCTITTACC
CGACCACCCA
GGGTGCTGAT
TAATCAAGCT
ATCACAACTC ATGAAACTCG GGTATI'AITA GCGGGCTI'AG AATCAATGAA ATGAC TITGT ITI'AACCATG CCGTGGATGA CATI'CCTAAA ATCATAGGC
CCATTGAAAC
TGGTGGGGCT
CTITI'GTGCC
CGAACATGCT
TTATAAAATC
GTTAGTCAGT
TAAGT'A
TITAGATI'AC
INFORMATION FOR SEQ ID N'O:1362: SEQUENCE CHARACTERISTICS: LENGTH: 783 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KE: misc_feature LOCATION .783 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1362
AAAATGCTAG
ITAAAAGTGA
TTAGCGAACA
TACGATTATA
AAAATIT1A
CCTGGCACTI'
AATGTTI'AG
GATTATCGCA
GGTIITAGAG
CCTAA TrG
AAACCACTAT
GCGTTTT1AGA
ACCTTAAT
TTTGCGATAA
ATTATTTTAG
TAGGGGCGTT
AAAGCGCTI'G
GCAGCGGGTr AAGGGG1'
GGAGCTGTIT
TGATTCT
AAACGATAAT
CGCTCCTGAC
GGGTGAGTGG
GGCGAATGAT
AGTTAAAATG
CGTTAATGGC
TAATGGCGTT
AAAAGCGTGT
CAAAAACCCG
CGT1'ACAGCA
GAAATCTCTC
GTGAAAAATC
GTGGAGGTAG
TAGAGGGTT
AATGCTGGCA
GAPLTGGCTAG
GITITGAGGG
AAAAGCATC
CCTAACGATT
GCGTGAAAAT
AAGAACACCA
TCGCTrI'Ar1
GGGGAGCGGC
TAGAGTTTTr TGAAAGAA?1'
AAAAGAAGC
CTAGGTTTAA
GCAAAAGCCA
CGGTGCGCCT
GATCATAGGA
AGGAAAAAAC
CAATGCGTCT
AGGGCAATTG
TGAAATAAAA
Trl'GGGGCTA
AAAGACGCAT
CCCCAAATTG
120 180 240 300 360 420 480 540 600 ATGCGGGGCA GGCT =TAGA GGGCGTGGGC TTAAGGGGTI' ATTGTCTAAA AAGAGTGGGG CTTTGCCAA GCAACATGCG AATTTITI'GG TGAATrTGGG GGGCGCAGAA TTTGAAGAAG CCCTAGATCT GATAGAACTC GCCAAAACCA GAGTGCTACA AGAATATGGC A'ITCAITI'AG AAGAAGAAGT GAAAATTTA
AGG
INFORMATION FOR SEQ ID NO:1363: SEQUENCE CHARACTERISTICS: LENGTH: 270 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .270 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1363
U
*0 a S S
U
an.
S
a.
CTCAATAGCG
AACATGATGA
CAAGAAAAAG
GTGTCGGTAA
AAGACAGAAG
AACATCCCTT
TGGCAGCGGC
TGGCGGCTTA
TGGCTAGTIT
ITATTTATGA
GTITGA'ITGG GCTAGCAAGC CATGTTAGGG A'ITGATTCTT TFTAGAGGAA AAAGGCTATC TGGTTATCGT AACCAAGAGA
AGTGAI'GAA
AGACTTATAT CCAAATGGCG GCCCGATTGA AGGGTATOAT TAAACACGGC AGAATTTGGC TTACCCCTAA AACCCGCTGG 120 180 240 270 INFORMATION FOR SEQ ID NO:1364: SEQUENCE CHARACTERISTICS: LENGTH: 1131 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION l...1131 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1364
AAAGAGATAA
AACGAGAAAA
CAAACGCAAG
CCCACAGACA
AAATTAAAAT
ACTATAGAAA
CCATGAGAAA
ACGGCTITTT
AAAAAAGACA
CGATIAAA
TCTCATCT
ACTI'CTTGCC
ACTATTCATC
CATAGAAGCC
CACCACCACA
AAGAGCGGCT
ATCCCCTGTT
TTATAATTTA
CCACTTTTAT
GGCTTI'GAAA
AAAAACACTT
AATI'TATI'CA
AGAGTGTTGT
AATAATGT'A
TATI'CAGCGC
CTGGGCTATT
ACGCAACTTA
CCAATGCCGA
ATATGTATAA
AGCTTAGTTT
TTIAGAAGCG
AGAAGGCACA
CAATTATTTA
AGCGATTTCA
TGGTCAATTA
TACAGACOCT
CAAGGCAATG
7TrGCCCGGAG
AITGAAGCCA
AATAAGATTIA
GAAAATCATT
AACATGATCG
GAGTTCACTA
ACAAACGGGC
GTCAATAAAT
GTAGGGCTTG
TI'AGGGGTAG
ATCAATTTAG
CATAACGGGA
TGATIGATCT
AGGCATITGA
CTAGCACTTC
AGACAAATIT
GGGAAGCCTT
CTG'TTTAGA
ACAGCCCAAC
TTGTCAATTC
TAAAAACAA
GGAGTGATAT
TAGCT1'CTGC AGGAT1TAAG
ATATGACCTA
AGGCGTGATA
TAGTCTAAAA
TATTTCTGAC
GGTCGTAAAT
TACCCCACAA
CTCCCAATCT
AGA'ITGCGAT
TAAAGTCGAT
AGCGGATCTI'
TACCCCTAGC
TTTAGATCCT
AACCATCTTG
TCAAAGAGTG
GAGACTATCC
AT1'GACCCAT
GCTAACACGC
TATAGGAATG
ACCGCAGAAG
TGGGGCGATG
AATGATCCT'
CAAAAATATG
GATGTAAITG
AACAATGATG
AAAAAACTCT
CATGAATTCA
CCGGTAACGA
CCAAACACTC
ATACTTTATT
AGAGGGTGT'
AAAACAAATT
AATTCACCAA
CGATCTrAAA
CAAAATGCGT
TGTTAAACAA
TI'TTAAAGGA
ATGGCAAGCA
TTGGCAACGA
GCCACACTAA
AAGATGTCAA
TAAGATTGTT
TCTTCCAAAA
TGAAACGCTC
TAAAGATCAC
'ITTAATGTTG
CGCTCCTITrT
AAATCCTGGG
ACAAGACA'Fr
TTCAGGGGTT
TTATGGCCAG
CCTTAAGACT
AGGCTATGGG
G
420 480 540 600 660 720 780 840 900 960 1020 1080 1131 0* 0* 0 INFORMATION FOR SEQ ID NO:1365: SEQUENCE CHARACTERISTICS: LENGTH: 648 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/ KEY misc-feature LOCATION .648 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1365 ATAATGGGCG TT)GGAGAGAA AGAAGAGAAA 0* *00 U
GGGGCGAGTT
GTCTATGCGC
TGCGTTGATA
GCTAAAGAAG
GTGGAAGACA
TGTGAAGTGG
AATCTrTCT
AAGCATGCCT
CAAGTGTGTT
AATGATGAGC
CTGGGAT'GG
TCTCTAGGCA
TI'GATGTGAG
ATCAT1'GCGA
CGCCCATIGA
TGCAACTITG
CCATAGCGG
TAGAGGCTTA
TGATTGAGCC
GGAAAGATAG
GT1TAGAGTGC
CGCGACTIG
CGATI'CTAAC
CGTTTTGATC
AGAGGTrAAA
TI'TGCCCTTA
GCGTGTGAGC
TAGCGATGCC
AGGCCCGGTG
CGTTTAT1GCT
AAAGAAAGCC
GTGTI'AATC
TGCGTAGCGT
GCITTTAAAGG
AATTCCGCCG
AAGCAATTTA
TTAAAAAACA
ATGCTCTTTT
TIGCGTITAG
AAAAGCAATT
TI'GGAAGTGA
AAAAGGTGGC
TGTI'AAATCA
TAAACCATGC
AAGTGTTT
GTTATGGGGT
GCGTGAATTr
AGCCT'A?'C
TAGGCCATTA
AGCTrAAGC
GGGAAAAAAC
ATGCGGCT
GGTI'ATCACT
AGGCTATAAG
GTTATGCGAG
AAACATCAGC
GTTTGGGAGC
TTI'CGCCCTI
TAAGATTI'C
CAGCGCGAGT
CTI'TAACGTI'
CGCTITTGAA
120 180 240 300 360 420 480 540 600 648 INFORMATION FOR SEQ ID NO:1366: SEQUENCE CHARACTERISTICS: LENGTH: 768 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION .768 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1366
GACTCAAATA
AGCATCTI'GA
CCTAGAATCT
GAAAAAAAGA
AACGATTTAA
GATATAGAGC
GCTTCTCTTT
TATGCGCTA.A
ATI'GTI'GGGG
ATTIGATAGAC
TCTAGAGAGC
CCTAAAGAAG
ATTI'TAATG
GAAGCGCTT
AGATAGCGTT
T1'GATGT1'GC
AAGCGTCAAA
AGCGTGATAA
GTGGTTI'AT
cTAAAGACAT
TAGACAATAT
AT1'CTF1'GAG
CCATGAGCGA
AAGCGTTAGA
CGTTAAAAAA
GCGCTTACCG
TATATGCCAC
AAAAGTITTTA
AGACATAGAA
ACAAAGCTAT
GATAGTGGAT
CCCGCCTAAA,
CGTAATAACG
CCAACATAAC
CGTTCAGTCG
GCAGTTTCTC
GTGGGTGCGA
TGCGGAAI'A
CCTI'CAAAAC
AATCTAGCGA
TCAGAGCGAA
CAAGAAGAGA
AAACAAAACC
AAAAGAACGA
GATITGTTAA
ATAAAGCAAG
ACGCTTGATG
CTTTATGTI'A
AACCATATI'G
TI'ATCGCAAA
TCACAAATTG
GATC'FTAAGA
TGGTITTGAT
AAAAAAATCG
GGGAAGTCAT
TTCAAATCAA
TITTTAAGCGT
AACAATTAGA
TAGAAAAATI'
ACACGCTI'GA
CCTTIAATCT
GGAAATITGGG
CTAAACTGAT
AAGAAATATI'
AAGGGCGA
GATITI'CACA
TTATGGTITTT
TGA.ATGGCGA
TAAAATCGCT
GATAGACGCT
AAAAATTAGC
AGAGCI'AAC
TrI'TACCTTT
TGTGAT'GAT
GAGTTTTGAA
CAFI'GAAACG
GACCGGCTGT
120 180 240 300 360 420 480 540 600 660 720 768 9 9a 9 a.
9* a a INFORMATION FOR SEQ ID NO:1367: SEQUENCE CHARACTERISTICS: LENGTH: 588 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geriomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .588 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1367 a a a
OGCAATOCTA
GGATTAACCA
TCCATI'GTT
GAAGGTGCAG
ACTGGGTTAT
GATTGGAGAC
M7TTATCCC
GATTGGTGGG
AACATCTTGA
'ITAACCGCT
GGACTTGTAT
AAGTCGATCC
GTAATGTGGT
AAGATATI'GT
TGTTGGTT
CCTATTCTTG
ACTATAGCGA
CAATCATATG
AAATCCCTI'
GGATCCCTGC
TGTI'ATATGT
TAAAAGCACC
GGTCATCACT
TCAAGTATCG
TACCTACTIG
GTATAGCTTA
TATGCTI'GAT
GTTGGCTTGG
AGGGAAA'ITC
TI'GG'ITACTC
TGGGATTGTC
GCGGTGATGA
TACTCCGCGC
CACCATTTGA
TATGCCGCTA
TTCGTAGCGA
GACCACAAAG
GGTGTITrGT
ACTCCATGGC
TITATCCAAC
TTAATCAGCA
ACTTTITTGT
TCCACCCTAC
CCAGTFI'CTA
TCAACCACAC
TCAACACTGT
TGTTAGGCAT
GGCFI'ACCGC
TI'GCTATCAT
ACTGGGTG
ATGGGATIGC
GGGCGGACTr
AGCCCCTGTA
TGGGCCAGCG
m'TGGTTTG
TCCTGCTGCG
CACTGAAGGC
TTTCATIGAA.
TGAGGGTATI'
INFORMATION FOR SEQ ID NO:1368: SEQUENCE CHARACTERISTICS: LENGTH: 1920 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) M4OLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .1920 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1368 C
C.
.PCC
C. C.
C.
C
S
AGCATTTG CC
TTTGTGCA'T
GGGGTGGATG
TCTAAAAATG
GAAGATITGA
TACCTTAATG
GCTGATAAAA
TTACAAAGAG
GGGTGGGATA
CTCATTTGCG
CTAGCTFI'CT
GTGGAATTTA
GCGAGTTCAA
AGAGCCGATC
AAAATGCCCA
TCCACTAAAG
GTGCATTTGG
GCTCAAATCG
GGCGATGATG
AATAGAAAAT
CTCACAAAA
TATAATGGCG
CATCTGGGCA
GAATCGCATI'
TTA?1'CCAAA
TITGATAAGGT
AGCG'TITTAG
GCGAAAGAAT
ATAGACAACG
TACCATTTT
AGGTGCA.ATG
AACGTGCTAT
ATGAATATT
ATAATGAAAA
CTTI'GAGTAA
GGGTITI'GAG
AACGCTATGC
TAGAAATCAT
TTAAAGCGTA
ACAAAGAATT
T1'AACCATAA
ACCACAGCGG
ACTACGATCC
ACGCGTATGT
TCTCT1'ATGG
GGTTCAAGCA
GACTGATCGT
CGGTGGAGGG
TTTTGGCCAC
CCAACCGCAT
CGGCTI'GTGA
ACCACACCAA
TACACGCTGA
AGACACCT TT
AAAAAGTGGA
TGTIGGTGGT
ACGTI'AAGAG
CTTTTGATGC
ACACCGCTAT
TGCACGACAA
AGCAGTATTG
ACAAGTTAAA
GGAAAACTr AAAGGT1'AAT
CGCCAAAGAC
AGACGCGCTI'
CTTTGTCAAT
GGAGTTTr
CAGCGATCAA
TTACAAGCAA
T1'GGACTAAA
GGAAGTGTGT
GAGTGGGAAA
CGATGAAGTC
AGCAGATCCC
CATCACTTTC
G1'TTAATGTG
GGTGATTGAT
GCATI'TAAAC
TCAAACCATG
CGCTrI'GCCT
GATTCAAAAC
GATGAGTGTC
AT1'TAACCAA
AAAAATGCCC
TrATGAGCAA
GATCCAAGAT
CGCGAACAAA
ACAAAAAGAA
GAATCCTAAC
AGTAGGGGCG
CGTCATTTT
AGAATTGTI'A
GAACGCTATC
TTGCAAGAAA
TCCTTGCCTT
TATTATCTAG
TTGGAGAGCG
AAAGACAGGA
GGTATI'AAAT
AAAAAAGAAG
AGCTCTCAGC
TrTAAAATCG
TCCAATFI'CT
CAAC-TCT =1
GCTITAGAGC
TTGAAATGGC
AAAGATI'TAA
GAATTCAGG
ACCCTGCTTA
CGCGGCACTG
ATGGATGCAG
CCAGAAGGCA
CCTAAAGCCC
AGAAATCTCG
GACACCCTI'A
AAGGACCTGA
TTAAACGCTC
GAATTGGTTT
TACGGCATCA
AGCGCGCTTG
GAAAAG'FTAA
GCGCATGACT
AACAACCACT
AAAAGCGATT
AGCGTTACTG
AXITAGCCGG
TAAAAGCGCT
AAAAGATCAT
AAAAAAACAA
CAAG'FITTGA
CCCAACACAT
TTAAAAGGGA
ATGAAGTAAG
GTAACGAACA
TGCATGTGT
TGTAGACTA
ATGCGAGGTI'
'TTTGTGATGA
GCGATTACCG
TGCTF1I=AG
AAAAGGGCCG
ACATTAATCC
AAGACAGCAG
TITTCAACAA
CTGATGATIT
CACCCATAGA
AGGCTAATGA
TAGTGGAGTI'
GCATCGCTT
'FITGCAATAA
CGCCTGTAGA
TGATAGACAA
AATCG iTITI
TTAGGCAAJAT
TCAAGCAATG
TGCCTCCACC
AATTCAGGCC
TTAGAGAT
TIT1'AAGC
GCGTI'TTGGC
TCAATCCGCA
GGGGTI'AAAA
GCAAGAC'FTC
GTTGAAGGAC
CGTGCCGGTG,
AAACCACACG
GATTCAAAAT
TAAAGAGGGG
GGTGAGCGTG,
AATGCAAAAA
CAAACATGAA
CGATAATAAA
TAGCTATGGG
AAGCTITAAG
TAGTGTITTTG
CAACGGAGGG
CAAATCTTTTI
TCGTAAAATC
AATGCGTIG
TGAAAGTAAC
AATGAAACTC
AGAAAAACGC
AAATATTA
TCTCAACGAA
AGAAAAAGCC
TAAAACTAAT
CCTAGCCT
AAGCAAACI'
TTTCAGCTTA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1800 1860 1920 TGATAGAGCT TTCCAAAGAC IVF ORMATION FOR SEQ ID NO:1369: Wi SEQUENCE CHARACTERISTICS: LENGTH: 264 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION1 .264 (xi) SEQUENCE DESCRIPTION: SEQ ID N0:1369
AGGCCCAATC
GAAAGCACCC
TCCACAAGCC
ACCTI'ACAAG
ACCCAAAGAT
TCTCTAGCCA
TCCAACAGGA
CCATGGAATI'
CCATGAACGA
CCCACCCATG
GTTCCTTTAC ACGGAAATGC Tl'TAAAAAAA ATCTTAGGGA ACGATTGGCC AATCAAAAGC ATTAGACATG.GGTGCAIT1
CCAC
TGAGC ITAAA
TTGAAGAAGT
TAGGCAATCG
TTAACGCTTA
ACTAACCTAT
CATAATGCTA
TTTCATTAAA
CGCTCAAACA
C.
C C. C C. C
C
*J C
C
C.
C C INFORMATION FOR SEQ ID NO:l370: SEQUENCE CHARACTERISTICS: LENGTH: 669 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAMAE/KEY: misc-feature LOCATION .669 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1370
GAAAAATCAA
ATCGCCACTC
AAGCTAAGAG
1
FIGCAAAAAC
CTCAAGCCGA
CAATI'CACAG
GGmTTATTGC
TATCCTTICC
GAAATGCTCA
GATGCGTI'GA
GACTTTATT
CATTTGCCA
CGAGCAACTr
ACAAAGCGAG
GCGCTATGGT
TAGACGATGC
TCAITTTCACC
ACGCGCCGAA
AAGTTAGGGG
CCCCTAAAAG
TGCGCTTACT
GCTTGGGGGG
ACCAGCAAAG
GAAGAAGCCA
ATCGATAGGC
GAATATCTIA
CTTAGATAAA
AATAGAGGAC
GITCAATGAA
CAAAAATGGT
CTI'GTATATA
CTCCAGCGCG
CATTTTCAAT
GATTI'TGACC
AGCGTTTGGA'GAAGCAAGTT
TTATGCGTGA
AGGATAAAAA
GTTGTIGCTA
TACCAAAAGA
GAGGGTGCTI'
GCTAACATGG
GAGCATGAAA
CCTITAGTGC
CTGGCCAGAA
GAAAGCAAGG
AGCCAAAGAG
TGAI'GAAAT
AAAAAGAGCC
GTGTCAGGCA
ACCCTCAA2T
AATTTATT
AAGACGGGCA
AATTGGAAGT
GGCTFITTAGA
AAATAGAAGA
GATATGCAAG
CATGAAAGAG
AAGCGAATGG
AGAGAGTTI'
AATICAAGCG
TTrAAGCTGT
GCCTAAAGTT
GTIT1TlGAGA
GATCTTAATT
TAAAAACAAT
AGCCCTAAAG
INFORMATION FOR SEQ ID NO:1371: SEQUENCE CHARACTERISTICS: LENGTH: 339 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (i)FEATURE: NAME/KEY: misc-feature LOCATION .339 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1371
ACATGGGTGC
AGCTATGGCG
CTTrATGCGC
AACGACGGGC
ACCCTAGAAC
ATGCAGCATG
ATT1 9
ITTAAC
TTT1'TGCGGC
AAACTTCTAA
AAAAAATCTT
TAGACGAAAG
AGAGTATA
GCTTACGCTC
GAGTI'TGAAT
CATGGTGATC
ATTGAGCTI'G
CCACTI'GTGC
CTCGCGccTIT
AAACAACCCA
ATGGAATTGA
AIACTGCGT1'A
CAAAGCCCTI'
GCAGCAAGCG
TATATGTCT
AAGATCCCAC
AAAAGGCTITT
AAAGCGTCCC
ITAACCAGCT
TI'CAAAACGA
CCATGCCACT
AAGGCATTAT
CTI'ATCCCAA
CATAGAALAAA
CATTAAGGCG
120 180 240 300 339 9**9 999* 9* 9. 9 .9 9. .9 9 9 9 9**9 INFORMATION FOR SEQ ID NO:1372: SEQUENCE CHARACTERISTICS: LENGTH: 468 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geriomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .468 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1372 *9 S. 9 99* a CGAGCTTCAA
TGAAAAACIT
TrAATCGCTC
TGAGTCTGCC
AGCITGAATG GCACGGCTT TCTIITACA
ACCCGGCTAA
TTTGAAATGA
CCACCACCGT
AATCAAGGCT
TATATTCGGT
GGCATCATCA
ACACTATAGG
ACCAATGGCT TATCACAAGG
TTCCCCACTC
CTTGCITTCT
AGGCTCGGCG
CATGGGCTT
GATCAATATC
AACAAGTl-rA
GTTAGGCAAT
TATIGTCTI'A
TATGCGAATG
TATGTCGCTG
ACTAACGAFI'
CCGGCCTTA
GAAATTGATA
ATCCTTAAAG
AAAAGCTCAA
GCTTTAAAAT
GGGCTAGGGG
GGGGCGAAAA
GCTTTAAAGT
AAAGCCAACA
CGCTTGGCAA
TTATGAAC
AAAACGCCAT
CCAAGAGCAA
TGCTGACGCT
CAGAAGCGAA
CCCTACGACC
AAATATI'TTA
TACGGCCGCT
120 180 240 300 360 420 468 TATCAATCGT GTTCAAGGGG INFORMATION FOR SEQ ID NO:1373: SEQUENCE CHARACTERISTICS: LENGTH: 651 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .651 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1373
GCGGATCGAG
TTATTATTT
ACCCCTAAGA
TTGAATGCCT
GATI'ACGGCA
AGCCAAAAAG
TCGGCCAAAT
GATGATAT'G
GAATATGTGA
GGCCTGATTI'
CCTITCTTTGC
AGGAT.AAACT
TCATGACGCT
CTAAGGAGCG
TGCGCCAATT
CGATCAAAAC
TGGGCGATAT
GGATTGCTGC
TTTTAGGGAG
TCCAAAGGTT
CTTTCCAAAA
AAGAFI'TAGA
CTCTCACTCT
1:TI'TrI GTT
GATCCGACAA
CAGACTCATT
CGATAAAGAC
TTACATGACT
AAGGGATTI'G
GGATATTTT
TCAAAAAAGC
CTTGACTCAA
AGACAATGAA
ATAATCATGC
TCTI'GCTCTA
GAAGAAGCCA
TACATrAACA
CACAATACTG
AAACGGAGCA
TTTGGCAAGG
AAAGGTTTAG
GGGGAAATTA
AAAATTGCTA
AACGCTGATA
GGTATTTTAG
AGCACCCTFI'
ATAAAAAAAG
CGCCGGTTI'
AAGTAACCCT
TTI'GITITAG
TGAGCTATGG
GGAAACGCCA
TCCTTTATGA
TI'AGGATTGA
GCGAGCTTCA
AAGCGCrI'Tr T1'CTAAGCAA
AGAAGAGACT
TCGCITTTAT
TI'ATAAGCTC
CCAAAAATGT
GGATTTGTTT
CCTAACCCCT
AAGAAAAAT
ACCCTATGAG
A
S
*9
S
S. 55 S INFORMATION FOR SEQ ID NO:1374: SEQUENCE CHARACTERISTICS: LENGTH: 708 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .708 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1374
S
5*
S
S
GAAATCGCT
GAAAAAAATA
AAAGCGCTCA
AACAAGCCCA
GCTAAAGCTI'
AGCGAATACA
GGCTATGAAG
TTATTAGATG
GATGAGGGGC
ATTTTAACCA
AAACAAAAAG
ITAGATGAAA
AGATCGTGAG
GGGTrIAAA
AAGCGATCGC
TAGGGAGTTT
TGGCGCAATT
TGGAAAAGCA
AAGGCGGGCA
AAGTGGAAAA
ATFI'AACCGA
GCAATGTGGC
CGATCAAAGA
TCATCTCCTT
CCAATGGACG
CATTGAAAGC
TAAAGCGAT1'
CCTCTTITTA
CTTGTITGAT
CGCTATCAGC
A'FIGACCGAA
AGCCCATCCG
TAGTAAGGGC
TAGCGGCGCG
GAGCCTGAGA
TAACGCCCTA
CACATCCCGT
GAATTGCAAA
AAAAGGAATA
GGGCCAACAG
AGCGATAAAA
CGTCTI'ATI'G
GCGGTGCGCA
GATGTGTITA
GTGAGGGTGG
CTTAGAAG
CAATI'CTICA
GATAGTCATG
TCCAAAAAAT
AA.AGGGTGGT
AGGCTGGGCT
GCGTGGGTAA
ATC'ITATACG
GGGCCGCTCC
GAAAACCTrA
ACTTCTTGTT
ATITCAAAAA
AGGATTTGAG
AGCCGGAAT
CTATCATC
GTTCCAAAGC
GGGGCAAGAA
TAGCGATAGC
AACCGAGAGC
Ak?1'GACATIG
TGGGTATGTG
TAGCGTAGTG
ACAGGTTT
CACGATIT1'G
TGAAGCCGAT
TTTAAACCGC
120 180 240 300 360 420 480 540 600 660 708 INF ORMATION FOR SEQ ID NO:1375: SEQUENCE CHARACTERISTICS: LENGTH: 777 base pairs TYPE:. nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
jvi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .777 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1375 4 4 4*44 .4 4 4*4* 4.
4. 4*44 4. 4.
4
S
4* 4444 *4
GTGAGGTITTT
ATGTTTGATA
GCTGGGATT
TATATITCGC
T7,11TTAAAAT
TCTATGGCCA
ATTGTGATCC
ACCCAAAGCG
T1'GGGCATGA
GTGATCATGA
GGCTTGGCGA
AAATCCTTAA
ATGGGAATAT
GTI'ATTCTAA
ACACGcT1'AT
TAACTTTTTI'
A.AATTTCTTT
CCTTGATGTT
AGCTTATCCA
TTITGG2TT
CTGGTTTAGC
GTITCGCTT1'
GTGCGAGTAA
TCCC'TTTTGT
GAAAATACAA
TGATCATGAC
AAAATATAA
CAATTTAT1Tr
AAGCCCTTGC
AGAGGATATT
TGTGGTGGGG
TAGCIITICG
GCATTIFITA
GAGCAAATCT
GGGTrGGACG
GGACGCTTAT
ATI'GGTGGCT
CCGCGCGA'T
AAA'TCTTTA
AAAACGAT'A
GAGACAGCGC
GTG'IGCCT'
AAAGATGGTA
TITI'CGCTCG
TTFI'CCTGGG
GGCGTGTTTC
AACAGCATGC
CCATGCATCG
GGCTI'AATGC
TTAATGCTAG
GAAATTG TT
GAAAGCCTAA
CTCTT1'TAAC
TGATCCCGGC
AGGCTAAAAG
TGTITTTTGGG
TGAA'FrATAT
GTTTTGCGCT
AGCGCTITTA
GGCCGATATI'
TATGGTGGT
AAAGAGCGCT
CAGGGTI'GGT
CTAACTTT
GGATTGGATG
TTC!GCITTTTA
GTATATGTCT
GGTrI'CGG'rr
CGTGGGCATG
CGCTGGGGGG,
T1'TGTATAAA CCCC?1'TCTT
CACTTCTATA
GTTTGTAATG
TrI'GTTTTTA
GCTTATTTTA
ACAAAAT
120 180 240 300 360 420 480 540 600 660 720 777 4 4 4 INFORMATION FOR SEQ ID NO:1376: SEQUENCE CHARACTERISTICS: LENGTH: 594 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION f1.. .594 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1376 ATAGGAGGTG CGCATGCGTI' GTGTITGTIT ATAGTATTGA AACCTCCCCA TGCCGTATG GTIIITAT TCAAGCACAA ?F1'GACAAAT TGCTCAAACA AAA TTT AAAA GCGATCTCGC GCTGATrrAA ACACGCCAAA CACAATATAG AAAATAACAC GAGCATGCTI' AITTTCTAA TTTrATATTAT
TCCGCAAGCT
GCTTATGGGC
TCTCAGCCAT
AATCCTATCC
TAAAAACCTC
TAGCGGGTGC
CCI'GAGCCT
ACGCTTGAAG
CTTACATT
TACGCTI'TCA
GITTrGGCA
AAAATCCGCT
CAAGACACCC
TCTCAAATCT
GAAAAAGTGG
AAAGATCACG
GCTITTCATC
TGTITATTGT
XITTAGGGAG
TGTTCGCTrT
TATACCATGA
AAAAGACTT
TAGCCCGCTA
ATAACC 17I71
CTAAACATI'C
ATAACGATT
GGG'ITTTGGC
CTATAGCTTT
TITI'TCATGG
AAAAAAGGAT
TTTAAAAACA
TGA'FTTAAAA
TAAACAT1'AC
CCTAGCTTAT
GAAAAACGCC
TTTGAAGTIT TAACAAACGC GCAAATCCCT TTGGAAITAC GCCGCTACGC CTTA INFORMATION FOR SEQ ID NO:1377: SEQUENCE CHARACTERISTICS: LENGTH: 1374 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAHE/KEY: misc-feature LOCATION .1374 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1377 a b a a a a.
a. a a a a. a a a a p
CAAGATAAGG
AACXTTAA
ATGGACTTTA
CTCAATCAAA
ATIGGAGACTA
GAAATC'FrAG
TIGAAATA
TI'GACAAAAC
TTAGAGCT
9
A
TCTCAACTCA
ATTTCTGGGG
AGCGTGATCC
CATTrCTITGG
GAATTCACTT
AATITCCTTGC
AATGGGAAT
GTGGGCTGA
GCFI'ACCAAC
ATGGGGTTAG
TTGGGTAGGG
AACACITI'AT
GGCGA.AATGC
TTGCAATACC
GGTTATTAIT
GCCTTICTGT
CCCCTCCCAC
TI'GAAGCTGT
AAGAAAACCC
GCGTAACAA6A
ACGCTACCAG
TCTCTGATT
AAAACAAGCG
GCAAACACCC
GCAATGGCAC
TTCGGGGGTTA
CTAATAATGT
TGAGCGCGAA
TCTCTGTG'rr
ACGGCTATGA
GCTATCATrI'
AAI'CGTCAT
AGAGCCGTAA
ATCTTl'TGAT
TGTACCGCAA
ATTI1GTGGCG
AAGATCTTAA
GAGTGTAGCA
CC'ITCACAAC
CFI'ACAGGAT
TGGGGGGAAT
GCTTI'TGCG
AGATCTTCAA
CCTITIAGAA
TAGGGCTAGA
TT1TAGCGAT CAATAACCTTr
GCTFI'ATGGC
TGTGGCTI'AT
GGATGTGGGG
TGAAACTTAT
GAACCAACGC
r1'TCATGTTC CATAGGC'rrG GCATrCAAAC
ATATITI'GGT
CAAAGCTAAA
GGGGGAAATT
TTGATGTAT
TATCACTGGG
CTACCTAACT
CAGATTAAAA
TACATTGTGG
AACGCTATCA
CCGA'TrATT
AACACCGCAA
ATGGCGAGTT
GAGGGAGAGT
CCTAACCCTA
TGGATTCAAG
TTGAATGTGG
GGCTATAGCG
ATGTATGCGA.
GGAGGCAATG
CAAACAACGC
TGTCF1'ATGG
GCATTCAAGG
AGTGGCTTTC
TAGAAAACCA
GCTTGATTTC
ACACCCAACA
CCAATTI'TC
GTGAGGTTrIT
GGGTGGGAGG
GCTATGACCG
GTITI'AACGG
GGGCT2TTI'
CGAGTCATAT
CTCTCAAAAC
TAATAAAGTG
ACAAAGCGCA
AACAT1'GATG
CTCTITAAAT
TAACCCTAAT
AACCAGCCGT
AGAGCGCT'G
TGTCAAATAC
AGCGAGC'rIT
ATTGGTI'AAA
GAACATCATG
GAAAAGAAAC
CAATTC'ITCT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1374 TACAACTACA ACACCTGGAC AACGAGCGTG AAACAAAAAA GCGTGGTGCT AAAACCTCAA AGCGGGATGA AAGGTAAAAT GCAAAATCCA CCTI'CTAACG AATCGGTTIT AACGCTCAAC AAAAAITCCT ATrATTTTGT AACGGCGAGG GGCGACAATG TGGTGCGTIT TGTGGGTGAA TTTAACACTT TIGCGAGCGT GATCACAGGA GTGAATGCGG GGGTGGGGCT TAAAA.TGGGC! AATGTGGGCA. TGCGAGTGGC GTTT INFORMATION FOR SEQ ID NO:1378: SEQUENCE CHARACTERISTICS: LENGTH: 753 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .753 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1378
ACCATACTAT
ATI'ATTAAGA
GAAGCCCCGT
GCTGATTACT
GGGCCTTTCA
GATITATTGGG
TCCACTCGCG
AATGAAGTGG
ATCGCCAACT
TTGGCTATCA
GCTCAAAAAA
CCCTACGAAT
GGC'ITTAAAA
GCCCAGGGGC
GCATTGAAGC
TTT1'AGCGAA
TGGCTCAAAA
AAITCTTTT
GCCTI'AAAGC
CCTTAGCGTI'
AGCAATI'AGA
GGCTITCATT
ATCATGCCAT
TGGTCAATCC
ACGATTTGAA
CCAATA'TrG
TAAAAGCTAT
'ITTAGATGAC
'TI'GGGCATG
TAATAAAAAA
GTGGAATAAA
GTATTTGGAT
AAGAACCGGT
AAACTTCAT
GAACACGCAA
CAATG'ITGAT
CI'CCCGCCC
AAAGGCTAAG
TACATCTTA
AAGTATITGGG
TATACCATTA
GACTTTITAA
GACGAGTTGG
GATGAGAAAA
AAGGTGGTGG
GAAATCATGC
AATATCGTGG
AAAAAGTAT
GATTACATCA
ACCATATGGG
GAGTI'GTTGA
CTC
AAGGCATGGG
GATTCACGCT
GCATTTTGAG
CTAAAAAACC
TCAT1'CTGGT
TGCGCACCAT
TCATGACCGG
TGGATAGAAG
TI'AATAACCC
AGGTGATITA
GTTATAACTA
AACAAGCGGG
CATGTCTCAT
TAATGGGCCA
TAAGGATI'AC
TGT1'GGGACA
TAAAAACCAG
TCATAATT
GCATAATCTC
CCCTGGGTITG
TITGGTGCGT
TGAAGGTTr
TAATATCAAA
CTATCCTAAC
120 180 240 300 360 420 480 540 600 660 720 753 0 0..w ~0 00 0* 000S 0 S. p ~0 *9 0 0O*0 S S 0* p p.
0 INFORMATION FOR SEQ ID NO:1379: SEQUENCE CHARACTERISTICS: LENGTH: 2637 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .2637 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1379 0* S S 000 S ATTCATA'ITA AACGAAITI' CACATTGCCC CACTCAAACC TI'GT 1771TT~A AAAAAACCAA, AACCAAATGA ATCACTACCA ATCGCTTCAG GGCTAAAAAT 1 ITAAAATTCC AATACGAAGA TACACTI'CAA CGCTCAATAC 'AAAACCA AACTCATCCA ATCGCTAACG A TTI AGAACG GGGGGGGAAT TTTTATTTGG AAATACCATG GCAATGGCGA TATAATATCA GCGGGCAAGA ACCACCAACA TAAATTACT GAGCATTCTI' CATTGCCTGA ATCGGCGATA ACGATAAAAA AITTA GGCCTG ATGGCTCTAG CAAGAAAGCG CGACTAAAGT ACT1'CGCAAA ATAAPAGTCGT
TITACTTAAA
ATTCATGAT
TAAGGATTTG
AAACGCFFI'A
CCGTTATGGT
AAACACCTTA
CGACAAAGCC
ATCCGCTAAC
CTrAAAAGAG
AGGCAGTAAG
AGATTTAAAC
TITGTFTITA
CAATCAAAAC
AGAAGTTTTC
CCCCACCAAT
TTITTAAAGAA
GAGCGATTTG
GGATGTGAGT
AACACCCCAT
ATTATTAACT
ATCATGCGCG
CAAAATAAAA
TATCAAAACA
GATCAAGGCA
TTGCAAGAAT
GATGTGCATI'
CATATGATAA
GTGGATAGAC
GCGCTTATI'A
GGCACCGATA
AAGCTCCACC
ATTAAACCCA
GACCCTAAAG
AAATTCGCGT
TI'GGATAAAA
TTGAACAATI'
?I'AACCCGCCC
TGTTTTGGAA
TTACCT'TGG
TCAACGACGC
GCGACATIAA
TrGATGTGGC
TFI'CTAAAAC
CAGAGACTrC
ATGTCGCTAA
CCCCCATTGA
GCTCTGATAA
AAGACAAACA
CTGATGTGAT
GCGATACCTT
AGTIITTTA
TGGATAAAGC
TCGGGCATGC
GGGGGCAAAT
ATTATTICCTC
TACTTTTAGC
CTCCAAATAC
TAACACGCAG
CAACCAGAAT
TCAAAACGCT
GATGGAGGCG
TCGCGCCGCT
TACCTCCATA
TAGTAATGGG
CCTTGTGCCT
CAAACTCAT
GGACGCTTITA
GCGAGAACTC
TTTGCAAGGC
CTATCAAAAC
?I'ACGGGAAC
TGAGAT1'AAA 120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080
AACCTAACCC
GACGATTTAG
TTTFGTA.ACGG
GTGCTTGAAA
AAGTTGAGCG
GGCGATGAAA
T1'AGATGTGA
A.ATGAAGTGG
AAAGAATCGC
GGTATCCCCA
AAATTAGAAA
CTGAGTGAAG
GTGAATGGTT
TTGCCTAATG
AAACCCAATG
AGCAACACTG
AAGGAGCGAT
GAAGAGGGTA
CTFTI'GATA
CTTAAATTAA
CAATTAGAAA
GATACTTATT
CACTTGAGCG
GAAAACATCA
ACGACCGGCA
AACGCCGTTT
CCGGCAGTGA
ACGCCTI'GCG
ATAGGAG'TI'
TCCCTAGCGT
AGA'TFTrGG
GCGCTATTAA
AAAACTCTAC
ATGTGGAAAT
cTATTTCTTT
CTAATAACGC
GcAATGTI'GC
TCTCTAAGGG
CGTTTTrTAGA
GCGTTAAAAT
AAGTCACTIA
ATccTGcAAT TcATTGAATT
AAGTCATTAT
AAGACGCGAA
ACGCTAATAA
ATATI'ATCAC
CTAGCGACAT
ATCACATAGA
TCAGGCGTAA
CGGATATGGC
TGGCTI'CCAC
AAATTTGGAT
TTCGAGCGGT
GAGCCAAGTT
GTTTGTGACT
cGATAAGGTG
AATCCCAAAC
GATI'AAAGAT
TGAAACGAAC
TGCCTTAAGC
GAGCGAATAC
CCAAACCGCT
GAGTTTGGAA
AGCGCAAATA
CCCGCTFI'AT
CAGGCAGCTC
CTACCAACAA
GTTAAAACAA
CCAAGACAAC
TGAT7=TCT
CGCCCTAATT
TTCTGTAAGA
GCGTAATTA
AAAAATGATC
TGAAGTrITA
AGAAACTTAT
GAACAAAATC
TTTCATI'TGA
AAAAGGGTI'A
AAAGCGGTGC
AAAGACAATG
GAAACTTTAA
CTCCCTATTA
TGAAAGACG
GGGCGTTTGA
ACCCTGGATC
CAAAAAACCT
CAAAATGATG
AATAGCGTI
AACTI'GGATA
GACCCCACAA
ATGGATGCGA
ATCAGCGATA
GCTAAAGACA
ATGCATI'CAA
CAAAACGCCT
ATTGACAAGC
AAAGGGXT
GGCATTCAAA
GCTAAAAACG
AAAACACAAG
AACAAGTT
AATAATCTGT
TFICTAGCGA
CTGAATATGT
CTAACATGTA
TI'TAGCTAA
AAATCAACGC
ATITTGGATAT
CGATTAAAGA
GGATCATTGA
AAAAAGGGCT
ATTTCAATA.A
CGGCTA.ATGG
TTAACATGAA
ATAATGGGGC
CCGCTGATAT
TGAGTATCGC
ACCCTACFI'C
ACCTI'TCTAT
ACACCAAAAT
TACACAGCGA
CAAGCGTGAA
ATCGCCCAGA
ACGGCATCAC
GCGCTCATGG
TI'CAAAGCAT
CCAATCTCAC
CTTTAACGAA
TGGGGTT
CAA.AAGCGCG
TAACCCTAAA
CAAAAACACC
CAGCCGTI'TG
TCCCATTCTT
ACGCTTCAAT
CAA7TCTI'CT
AGA.AGTGGCC
AGAAGGGGCC
CTCTACTAAA
AT1AAACGAT '1'TTIGAGT
TC.AAGCGTCT
GCTCAATTAC
AAAAGAAAGC
TAATTTIGAAT
GCAGTTCATG
CAAACCAAGC
7IrI"'GAT
CGCTTTAGGG
CCT1'ATAGAT
TAAGGCATTT
TCGTGGGGAA
TAACAACTAT
GTATFI'A
1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1800 1860 1920 1980 2040 2100 2160 2220 2280 2340 2400 2460 2520 2580 2637 9* 9 INFORMATION FOR SEQ ID NO:1380: SEQUENCE CHARACTERISTICS: LENGTH: 543 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/ KEY misc_feature LOCATION .543 (xi) SEQUENCE DESCRIPTION: SEQ ID N0:1380
AGGATTGATC
TGTITTTAG
AAAAGCTCTT
GATGTGGATG
CGCAGCGATA
AAAGGCGGTA
AATI'CAAACG
ACCTTCACTT
AATCTCATGC
ACA
AAATT1AAAAT
GGGCTGTAGA
TTGTGGAGTI'
GCTCTAAAGC
AAGGCGTGGT
AGGCGTATAA
GGGATTTGGA
TGAAACGCGT
GCTCTTIrTA
TATGAAATTG
GTTGCCTGGA
TTTTGAGCAT
CAAAAAAGAC
GTITT'TAAGC
TTTTTATGAC
ATTCACT1'CA
GAGGGGTGCC
cAGGCAGACC GTGAGTCTI'A TTGTAGCGTI GTTTATCAAA CTCAAGAATT AACGGGAAGT TCTATGCCTA AAACTCAATC CTAACCCAAA GATI'TGATTA AGGTTGGGGA GGCAAGACCT ACCATGTGAG AGCTATGACA AATGGGGGTA GAAATCAGTA TI'TAAAGCT CACCTTTIT CTATI'GGTAA
AGTITI"ITGT
TITATACATG
TGGTATITCT
GCTAAGGAAT
ACAATCTTAT
AGTCACTCAA
TGTGGGCAAT
CAAGCGTTIT
GGCCTACGCG
120 180 240 300 360 420 480 540 543 INFORMATION FOR SEQ ID N0:1381: SEQUENCE CHARACTERISTICS: LENGTH: 645 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/ KEY misc-feature LOCATION .645 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1381
S
AAGGAT'ITAA
TGCGCGGCGG
GTG'TFTrGA
TTGGCGTGG
GGGGCAGTTT
AAAAAAAAGC
TIAGGCGTTA
AGCGCTATGT
GCCTTTTCTT
AACAACCAAA
AGCGTTACT
GCAAGATGTT
TGGGGGCGCA
T'ITGCGCCT'
GGGCT'ATFI'
TTACCGGAT
AAGTCCAAAC
CCTI'ACTCAA
CTTTTAACCT
GGC E TITAI'
AAATCTTTAT
TGTGG 2711"T
ATCCTTGTI'
GTGTTTT~ATG
CGCTAAAAAC
TTACGCTI I I
CCCTAAAAAA
TCCTCA.AGTG
AGTGCAAAAA
GTTATGCACC
GGGCGTGAAT
ATAGAAGGTT
AITGTGGAAA
TGCGATAITG
CTTTATITGA
TTGGCFI'AA
TrATCCTTAA
TATITGGAAA
ITCGTCTFI'C
ATGTCCTIAC
CTCTTTGTAA
'FrATTGAGCA
TTGGTFI'AGC
GGGGGATGGC
TCTTAATGAG
GCITGTITT
AAACCCTT
AAAAGACCTr TGGTGTITTr
TAGCTGGCAC
GCTATGGCTC
CCGCTATCAT
AAACC
GATTTCTTIG
TAGGAATTAT
CATGGGCGTG
GAATTTATT
TCAAACCTT
ATTATI'CACT
AATTIGGCGCG
TIATCGGCT
TAAACTTTTG
GGGAACGCTC
TATTCAGGGA TITI'TT AGCG
S
S
INFORMATION FOR SEQ ID NO:1382: SEQUENCE CHARACTERISTICS: LENGTH: 720 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1.._720 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1382 ATGGATATI' TAAAAGCAGA GATG TFI'CTT TAGAAGTGAA GGTAAAACCA CCACCTFITA TA TTTAAACG ATGTGGATrr GGCTACT1'GC CCCAAGAATC CTAGCAGGGG AGAGCACTT CTI'GATGCTT 'FIAATATCCA GAAAGAAGGC GCGTAGAAAT
GCATTI'AAAC
AAGCGGCGAA
CATGATATGC
AGCTAAATAC
CAGTATr'T1
TAAAAACTCT
AGCCATAAGA
CGCTAGGGCT
AAACAGATTA
GTGGTGGGGC
GGGCTTTTAG
CCCTIACACA
AAAGAATTGA
AAAGAGAGCG
GAGCGCAAGG
TTA.ATGAAAA
AAAAAACCAA
ITTAGGGCC
AGCCTAGTGG
AGCGTTCTAA
GCGTGGAAGA
AAGAAAAAAT
GCATGAGCT1'
ACCCTAAATT
AATCGTTTCA
TAATGGGGCG
GGGGAGCGTI'
CT1'GGGCATA GAA'TrGGCC
GGAAAGCTTG
GAGTGGGGGA
CGTGCTGTTA
120 240 300 360 420 480 GATGAGCCTI' 'TGCGGGCGT GGATCCGA'IT GCGGTGATTG AGVITGATTG GATI'AAACAT TGGCGTGTTG ATTACTGATC AGCGTGTGCC ATAGGGCGTA TGTGATCAAA AGCGGCACGC AATGAAATTT ATGAAAACGC TTTGGTGCGT AAGTATTATT
ACATTCAAAG
ACAATGTGCG
TFTTAGCGAG
TAGGGGAAAA
AATCAT1'GAA
AGAGACCTTG
CGGGAACGCT
TITTTAAGGTA
INFORMATION FOR SEQ ID NO:1383: SEQUENCE CHARACTERISTICS: LENGTH: 240 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geriomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .240 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1383 4*9* 9 *9 9* 9 *9 9 0 9 AACACTGGTT TGTGGCACTC TTGGGGTITG GCTCCAGCGC AAACATGCTC ACCAATFIT TCAAATCTTC TFTICCCCA ATCGI'ATTG TGGAGTTGCT TGTCAATTI'T ATCITIAATC GGGGTTAAAA TGATAGATAA TATCAAACTC CCACTTAGAC TTI'TGGAAAc
AAAAGCCCTT
TCTTTCACGC
GCATAAAAAT
GCAACTGCCC
CAAACAAATG
CATACATGTI'
GCGCGCTCTC
099s 99*9 9 *0 9 9 9 INFORMATION FOR SEQ ID NO:1384: Wi SEQUENCE.CHARACTERISTICS: LENGTH: 1644 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1. 1644 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1384 A?1'GATCTAG
GCGTTTGATA
AAAITTTGAAG
CTCAATAACA
AACACTI'GTC
CCACAAACCG
CAATCTI'GGG
GCGTGATAGA
GTTTAAAAGA
CCACTAGCAC
TTAAAACAAA
CTTACAATAA
CAGAAGAATT
GCGATGCGAT
GACCATCCCC
GGCGTITGAT
TTCTATTTCT
TCTI'ATAATG
TAATGGTAAT
CACCAATTA
CTI'AAACGCT
AAACACTCTA AGATTGTFT AAAATACC CCTATACTT GATACTAACA CGCAGAGGGT AAATATAGTA ATGAAAATCC ACAAAAAATG AF1'GTTGGCA ATGTI'GAACA TGATCGCTGT CCTITTGAAT TCACTAACAG
ACCCGGGGAG
CTITITTCCA
GTrI'GAAACG AAACAATrTC AAAT1'TCACC
TTTAGACTCC
CTCAACAGAT
TGCGATAGCG
GTCGATCAAC
GAAATI'GATG
AATGATGGTG
TFITGGCA.ACG
AGCCACACTA
AAAGATGGTC
TATAATGTGT
AATI'CCATCT
G TTGGCAGC
CAAACAAACT
AGCACCATCC
TCGCAAAGTT
TT7TAATGATT GT1'AATCAAA
ATCACCACTT
TCATCTTITG
AAAGTCAAAG
TCTAAATAT
AGCGGTGGCG
TTTCAATT
ATCCTTCAA
AATATATACT
CGGTIGTTTr
AATATGGCAC
ACCTTAAGAC
AAGGCTATGG
AAGTGGAAAA
G'ITCGCTI'A
ATCACAATTG
AGCTCATCAA
ACAACCTAAA
AAAAAACCTT
TTAGAAGCCC
TCATAGGGTTI
AAGTCCAGCA
ACTCCAATAA
GTATCTTTGG
GAAGCGCAA
CTGTAGGGAT
ATI'ATACGAA
ACGGGTGGGT
ATGCGTAAAT
CAACAAACAA
AAAAAATTCA
AFI'AGGGGTA
TATCAATTTA
GCATAACGGG
GGATAGTAAT
TGGGGGATTC
TGCGGATGTC
TCAAAACGCC
CGCTAGTTTA
TGTAACTTCT
TATITTAGGG
GGCTTATTAT
ATTGAGCTAT
AAATAGCCCT
GGGGTTAAGG
TTTAGATGTG
TAGCATCCCT
CTCTITI'GTT
GTT
CCCGGAGTAA
GGTATTATTA
GGGGTTGTAG
GAAGCCTATG
GAAGATTTAA
AATATGACCT
GGCAAGCCAA
AATCAGCCCG
CCGGCTGGCT
TTGCCGATCA
AACACGCAAG
AGCG'FrACCA
GTTAACGCTA
GGCATCATCA
GGTGGGGGGA
ACAGGCATTC
GGCTTGTATA
GCTACCGGGT
TTAATccAAA
TTCAATGAAG
ATGGGCGTGT
ATAATITrAG
GGTTAGCCAA
CTrI'AGATCC
GAACCATCTT
ATCAAAGAGT
AAGATTCTGA
C'ITTCCCTAG
TTTTAGGGGT
ACTACGCTAA
ATTTAGCCAA
ACCACCXTT
AAATAGGCTA
AATACAATTA
TAGATTTGTT
AAACCAAAAG
ACAGCTATTA
TGAACTACCG
GAAAAGCTAG
GGGCTAGCCA
TGATACTAAA
AAAAAAAATA
TGGATATGGC
TAAAAAACTC
GCATGAATI'C
GCCGGTAACG
TGGCCTTCcC
CAACTACCCT
AACAGCAGCG
CTTGGGGAGT
ITCCATGCTC
T~cAAAcG;CA TCAAAAcTAC
CGCTAAAGCT
ATrGGATTTc GAATTrTTCT TGTGI'TGAAc
CTATAAGCAT
CGTCGTTrCT
CITTAAGGTG
480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1644 a.
a INFORMATION FOR SEQ ID NO:1385: SEQUENCE CHARACTERISTICS: LENGTH: 1260 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEy: misc-feature LOCATION .1260 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1385 a.
S a a
GATCATAGCT
ATTAAACCCA
GCGTCCATTA
CAAGCCCATA
GATFI'AGAT
TTAACCGATA
GCTITCCTATG
CTCAAAGAGT
CATTITATG
GGCGTGAAAG
GAAGGGCTTT
CGTI'TCCAAA
ACTFI'ATGcG
ATGCGGATCA
GACATI'ATCA
GAAAAAAAGG
TTGAAATAT
GTITTCACTA
GTTTCCGGGG
TTAATATTcA
TAAAAGCCCC
GGCGCTGGAA.
AAGCGATGAT
TAGATC7rrr
TTAAACCCCC
TTGCGCAAAG
ATIAAGCCA
CGTCTAAGTG
AGATTAAAGA
TTGGGGAAAA
AGCGCTGGAG
TGGCGATTAT
ATCATF7rrI
CGCCCATCAA
AAATGCAAAA
TCACCGAAAA
AAGACGCTGA
AGCTT=GAA
AAATAGTATA
TAAACTCAAA
TGACCAAGCA
TGCGTATCTG
AATCAAATAT
TATrI'TrrAC 2tTGCAAGAT
CAGGCCTCAA
GGAGTITAT
TAAAATTGAC
AGAAGATTTG
CCAAACCCCA
GGGGTATFTA
GGGCGGGCTT
ACAAAGCGT'
CAAAGTCTAT
CGAGITTTAAA
AGAATTAT'C
GGTGTGCGAT
AAAAGGAAAG
TCTCAATT
TGCCCTTrGG
CTCGCTAG
TITI'GCTTrG
GCCCTCCAAC
GAAATCAGTG
ATTTAGAAA
ATTATCTATC
AAGCAACTCC
AAAAAATTGG
AGAGTGCCAC
TTGAGTFI'G
TrCCATGATr GCAGGGcTTG
TCCTTTGTGT
AACCGCTACA
ACGCTI'TATA
CATTTGAGCG
TCATGTATGc
TAAGGCGTGT
AATrI'GTGGA ATTrAAA.AGA AGrTTTTGGA
AAACGCATAG
CGTATrF~c CTCAAAT'rr ATI"ITAACcc
ACAATAACGA
TGAGCATGTT
AAACCAGTGT
ACTI'GAAAGc
TACCCGAAAT
ATCATI'CCAT
CTFTGGG=CGT
AAGACAAGTC
ATAGCGATGA
CGII=AGA
GGCTCATCCT
GTTTGTGGt-Gc ATrAGACAAG
TAGGGGTAAA
GCGCTTGGTr TAAAGAGTrA
TTAGAGGAA
AGAGAGCGCG
CAACATGTAT
TCA'FITGTTr
TGGGCAGTTG
TCTAGGGCAT
TTGTAAAAGc
ITTAACCCGA
TAAAGAGATr
TCAAGAAGAT
TCATCAAATC
ATATCTGGG
AGCCCAAATc 120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 TCTCTICTC ATGGCATITC TAGCTACGAT FrAATCCAAG GAGCTAAAAA CCj~rr1jAiAIf TTGCGATCCC AAACGGAACT GCTTIGATTl'G GATITAGGGA AATTGTFI'AG AGATITTAAG 1.4U U 1260 INFORMATION FOR SEQ ID NO:1386: SEQUENCE CHARACTERISTICS: LENGTH: 804 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1...804 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1386
C.
C C C C
AATATI'ACAA
AAAAAATGCT
AT1'GAAiACCA
GCGTI'AGATG
AAAGAGTATG
AATCAGGGCT
CAAAAAAAAG
CCTAAAAGGA
AAAATGGAAA
AGTGGGGAAT
TTCT1'AAAAA
ACGGATAAT'
CAAGAAATGG
GAATI'AAAA
TCAAGGATAG AACG rTTTAGGCGC
GAGCG
ATGAAGTTGC
TTTG~
AAAAGATITIT
ACTT
AAAACAAAT'
CAAGI
ATAAGGTI'AT
TAATG
AAGGGTATTI GGCTC CCATACAGAA AAAA1 GGGTTI'AAT CCCGC CTT1'GGAT'C ?I'ITI CCACCCATTC
AAGC(
CTAATGACGC AAMh ATAAGAAACT
CACTC
ACAAGAGAAA CCGA
,TGGTG
AAT1'G 1AAGG
ICAA
;TGGAT
TCGCT
~CAGAA
;CTGGG
~CATG
ATAGC
'~AAGC
:AAAGG
ACAAATGGTC
GCTTTAII'AG
AAI'TACCATC
CCAGCTITCC
ACCACGCTTA
AGCAGCGATA
ATGAATGGCG
CCCGGGTTAT
TTTGTCAAGG
GATII'GAGCG
GGAGGGTTAG
GCTI'TGAATA
AATTTAGAAT
ATIITAAGGA.
TGGGGTGTAG
CAGCTAGCGA
AATACAGCGA
AAGTI'GAAGA
AAGACGATTT
AAATTGTTT
TA1'TCTCCAC
TTACCATACT
AGTTGGACAT
TrAGCACTAT
AGATITTI'GC
CTTATCAAAA
TTTGCATGG
CCCGCATATI'
GAAAGTI'CAA
TAATATTGCT
GATCTTGCAA
TTCTITTGCG
ACGCCCCGAT
TGGTTTGGAT
AAAGCCTATG
CCAAGAAAAA
GGTTAAGGGG
AAGTATCATIG
AGACGCCAAG
120 180 240 300 360 420 480 540 600 660 720 780 804
C
INFORMATION FOR SEQ ID NO:1387: SEQUENCE CHARACTERISTICS: LENGTH: 300 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc..feature LOCATION .300 (xi) SEQUENCE DESCRIPTION: SEQ ID NO;1387
TCAAATFTA
GGGATTFTTAG
TTOCAACATG
ATAGAAGAAG
TGCTCGGCTG
AAAAAGGTT
GGGTI'AGT
ATCATTATCT
CTTTGAAAA
CTATGAGAAT
TTTTATGTT
GGTGGTI'1T1
ATCACAAGTG
GGATAGCGAA
AGCTGCTGGT
AAAAGCAGAT
TGGGATGTCA
AAAGAAAGGG
TGCTTTGAA
GAAAGAAATA
TAAXITCATG
TAAAATACAA
AAGAATATI'A
AAGGAGGCGA
GAAGAATGTI'
GATTrATTA
AATAGAAGAT
TAAAAACCAC
TAAAGTGGAT
AGAGAT1'AAA INFORMATION FOR SEQ ID NO:1388: SEQUENCE CHARACTERISTICS: LENGTH: 726 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .726 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1388
S
S.
S.
S
5555
S
*SSS
S
*S
S
AAATTT
CATrI'CAAAA
CTAGAGCAAT
TTAGAAA'FIT
TGGGTGTITA
GAAATCACGC
TTTGTTATA
TACCCCAATA
TC.AAAGGTI'C
GAAAATrI'AC
TTAAAAGACA
GTCTTGTTTT
AGTTTG
TAGTTATAAT
ATGATAT'AC
ACAAAGAAAA
AITI'ACGCAA
ACGAAAGCGT
ATI'CTITAAT
AGTTAGAGGG
ATAAAAATGC
ATATI'GCTT
TCAAAATCCA
ATGATAGGGC
TAGATGATTT
TITTCAAAAA
GCTCATI'CTA
TTTAAAACTC
CGCTF1'AGAC
TTTAACCCCT
CTTATCTAAA
GGTAATATTA
ATIATTTATC
AAACTTGCTA
ACCGAACAAG
AAGAATI'CCT
AATTAAAAGC
ACCTTAAGAG
TCTAAAGACA
ATTGCTTTCA
TA LTGCCTGA
?I'AATCAAAG
ATGTCTTTAG
GA'FITAAAGC
AACAATAAGA
TGGACAATI'A
CGCCCACGCA
ATGAATATCA
ATCGGAAATA
AAATCATGCA
GATTAGATAC
TCACGCCTAA
CTCAAATGAA
AATTAAAAGA
GGGCAGTGAT
GCATCANTr
AAAATCCATT
GAAATCGTGC
rTTACGACTI'A
GTGTAGAACC
AAGACITGGA
AGATTTACAA
TTATGACAGC
AATII'CTAAC
AGGGAGTGAA
AAAGAAAAAA
CAGGCT'AT'
CAAATCCTAT
ATCTAGTGCT
GTATCATTGG
T'ITCATI'GGG
AAGTAAAATC
AGATTTAAGT
120 180 240 300 360 420 480 540 600 660 720 726 INFORMATION FOR SEQ ID NO:1389: SEQUENCE CHARACTERISTICS: LENGTH: 1401 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .1401 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1389
GGCATGAAAG
TTAAACCACT
GGTGCTAAAA
AGGATCAAGC
AAAGTGAATG
CCCAATCCCA
ACTGAAAGGA
CGCATCTCTG
GAGAAA&ACT
CTAAAGGATI'
GCTGGACTI'A
GCGGCTAAAA
TATACGGCTT
AATGTGTATG
ATGGATAATG
TATTGCAAGA
AATCGCTTAA
AAAAAAGGTG
AGCGTAGAAA
TTAATGGTGC
ATI'CCTGCTG
CAAGAAATAG
GTAGGAAAGG,
ATCCAGTCGT
CGTTGAAGAC
TAAACGCTGT
GAGCATGGGA
TCGCTCAAGA
ATGTTI'TGAA
TGCAGTATGT
TCAAAGAAAA
AA.AAATGCCC
TACACCAAI'
'FTGCTAACGC
GAGGCAGAGC
AAATCCAATT
ATGAAAAACT
CGAAAGTCAA
AGTTGGGCGT
AAGAAAACAG
AAGCGCAATT
AAGCAGCCGC
CTGCTTTAGA
AAATGCAAAG
ACGCCCTAAA
AGAAAGTCTA
CAAGTGGCGT
TTTTTAAAA
GGCTATGATT
TGAAAGCAAG
CACATrAGAT
CAAAACCAAT
AGAAAAA.ATC
TGCACAAAAC
TGAACTCAJAT
TTITCACGAGC
CATAGGTAAC
CTTAT1'AGAA
ATAGACAGC
TAGAGCTGAA
ACAGCT1TGTT TAAAACTTT1'
AAATGGCAAA.
TGATGAGCT
TAAAGTGTC
AATCGCTCAA
CTATGCATI'C
AGATGACAAA
TAGGGCTAAA
GAATCAAAT
AAATCCC'FTA
GTGGATAATC
TGGGCTAAAC
AGGGCTAATC
CAATITCTAA
CAAAGTTG,
TATGATATAC
TGGGATGTCA
AAGGGGAAAG
ACTCAAATCA
TACATFI'GCA
CAAATGACTT
AAAGAAGAAT
GTAGCTTCCC
GGGTTCAACG
AGCGAGTGCA
AATI'TAGATI
AATGACTACA
AATITAAGT
AAGCAACAAA
GAGCATCAAG
TI'AGACGCTr
AGTAATAATG
TTCTGT'ACT
CTACGCAGAA
ATTTAGCCAC
AGACGCTI'AA
CAGGCAGTAT
CCAAGCAAGT
GCAATCAAAT
GTCAAGACGC
AAAGCGCTAA
GCACGGCGAA
TTCAAAAAGG
TAGCTCTACT
TAAAAAGACA
AAGATAGAGC
ATGAGAATGT
TCCCTAACAT
ATAGTAGGGA
AACACCGATT
TTATGAATAA
TGGGCTATTI'
AAAATCTTGA
ATGGTTTCCC
AAGCCCCAAG
AGCAATI'GCC
CGC'ITGGAAT
TATTACTGAA
TTCCATCAAC
TITAAGCATC
TCAAGCCAAT
TGCAGCCAAA
GAGCCCTACA
CACAAAGGCT
CGATfl'AGGA
CAAT~TAGAA
CAATAACGAC
AATCGCTTCA
GITI'AGTCAA
TAAAAAGGT
GCTCAATGTT
TATTGCTGGT
CCAACAAT'A
GACGCTAGGT
TGAAGATATT
ACAAAAACAA
TAATGGTAGT
CTC!TGATAAT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1401 U. U. *U U U *9 U
U
U. TI'A7ATCCGTA T
S
INFORMA.TION FOR SEQ ID NO:1390: SEQUENCE CHARACTERISTICS: LENGTH: 1272 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genornic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1 .1272 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1390
AGATI'AAATA
CTI'GGTGCTT
TTAGTI'GTGC
AGCAAGATCT
GTTTTAGGAA
-1TG"AAATCA
TATGCTI'TA
AATCATGTAA
GTCGTTAAGG,
AGTATCACTA
CTATATGAAG
TTGTTATTAG
ACATGGCCGC
TAGCTGTCAT
AAGCAGATGG
TGAAAGGAAT
TGCTTI'TAAT
AAACCTTI'
AATCTGATGG
CAGAAATITT
AATATCAAAC
ACGCTAATAT
ACTTCAAAAT
TTATTFITAGG
TCCACTACTT
AGGAGTGGGT
GCTTI'ATAGT
TGGTGAGCCT
CCTTTTGTAT
AATGCTTF
TCTAGTAGC
TGACACGCCT
AAATAGTGCA
?I'CATTCCAT
TAATAATGGA
A?1'AGAATIG
GCTCTGCCCT
GCTI'ACTI'GT
GAAATTCTIG
TTAGCCAATG
TCC TI'AAAC
GTGTTTGTAG
GGTAATGGTC
GCTAACT'GC
AGAGAACACA
GTCAGACAAA
CTATCGCTAA
TTrATI'GT
TTCTTTCTAA
ATCCCAATAA
GGTITUCAT
TI'ATCCAACC
GCTATCAAAA
GATACC'TI'C
GCTCCAGT1T
TAAATGCTGG
AGAATATAGA
TITI'AACGAG
AAACCCrAT
TCAAAGTITIS
CCCTITAGTG
GCAAGATTCT
TTCGTTTTi"CT
TI'TTGGTATG
CAATGATITA
TTTGTACCAT
TGCCTTTCAA
GATTTCTAAT
CACGCACCAC
TTTGAATAAA
TGCAGCTGTT
CTGTTATGTT
TTT ATGACTTA ITIAGAAAA GGGTIrT=C AGCAGACTAG ACT-"ITIACA TGCCFI'GTT GCAATCAAAG TGGGAGGGAG GGAATTTCAC TGACATTIAT CAAGGTGGTC TAACGGATGC GGAGCTGGAG CCATAGCTGG CTAGAAGCTI' ATAAAGACGC ATGCCAGGAC ATCCTGGTGT AGAGCTAGCA AA
AATTATI'TAC
AGGTaITIA
GTTGCTATI'A
CAATGAAATA
TCAAAAAGTC
TAAAAGCTI'C
AAGTCTI'AAG
AAAATCTACG
TAGAGTGGGT
TI'GTCTTTGG
GTGTCTTATG
GTGTTAITCA
GTGGCTAAAT
CCCGAAATGA
ATATATCAAG
AGTGTGGGTO
ATAAACAGCA
GTGGAGACGA
TTATI'?ICAT
TGAAAAAAAT
ACTCTFITGC
TTGGCATTAT
TTAACGCTAT
GTGTGCAAAT
G ETCAGCATT
CTACGGCTAA
TTGAACTTCC
GCTACTGCTA
TA'FrCA'FTG
ATI'ACAATAC
TGTAGCAATA
CTTTGGCACA
GGCTAGTGCT
TGGTAGAACG
CATGAGAGAC
CAAGTCTCAT
780 840 900 960 1020 1080 1140 1200 1260 1272 a. a a.
a INFORMATION FOR SEQ ID NO:1391: SEQUENCE CHARACTERISTICS: LENGTH: 1152 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1152 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1391 AAAAATCGCT ATC ITAAGAG AAACATGCCG CCT1'TFIGT CAAACCTCCC CCTATGCTT TI'CACGCAAC TCACTATCCC ATCAGCTITGC CTAACGACAA AGGGATGTGA AAATCAGCGC TTCATTCTTT TAACCAAAGA GGTAACCCCT TGCTTTI'T ATGGGCGGGT GGGCCACTI'C 'FFTAAGTITG CGCGAAAACT AAIAAGCCTI TAAACACCAC ACCCAATACC CCTTGTGT CCTAATACCT TAAACCACCA.
ATGGCGTITA GAAACCATTC ACTGATTGGC AAAAACCCAT CTCAA TTFAA ATGGAATATT AAAGAACTT GGCTTTCTAA GATAAAGCGA ATGAAGTGAG GTCTATACTT ACAACCGCTC TCCCTTCTCA AG
GGGGCGAAAC
GGGGCITTT
CACGCATAAT
TAAACCAAAT
TCTITI'GAGC
GAATCTTT
AGAGCITI'CT
GCATGATAAT
TAAAATCTAT
CTCTTTAAGC
TGATGGCGGG
GAAATITGAC
GCTCCAACCA
ITTTAAAGAT
TI'CTACAAAT
GTA'TITGATC
ATTAGAAAAC
!FTACCCAAGC
TCATATCAAA
GCTATC'ITGG
ATCGTI'GT
CAAGCCCTTG
GACGCTI'AA
GCTTATTTTA
GACAGCAAGA
CATCAITCGC
AAAATITI'GT
CAATITGAAA
CCTITITIAA
TI'TATGCTAC
CAACAAAATA
AGCTTAACCC
AGCCTCATGC
CTTAAAAACT
CACAACCCTA
TCCAACTCGT
TATAGCCT'A
CACATCCGT'
AACCT1'CAAG TrTTTAATI'AT
TCACTCAAAC
GCGCGCATGC
GCGGCACTAA
CTAATCGCTG
ATGAATACAT
TGTTTGTCGT
GCGCF1'TAGA
ATI'TGAGCCA
CACTCTATCA
ACCCAAGAGA
CCITTTAAAGA
TAGAAACCTG
TAGATGATTC
GCGATTTATC
TIAAAACCT
ATCCGCAITT
TCAATATGGC
AAATCGCCTA
AATGAAGCAC
CCCCCCCTAT
GAGCTCTTTIA
AGAAGGGGCA
GAGCGAAGCC
CAAAAAATTA
AGGGGTGAGC
GCCGATTCAT
TTTAGTAAGG
CGAATI'AGCC
GCTI?1'AAGG
CTGCGCTGTC
TAAAACCCCC
TTTAAA'TrA
ACTGCGTCGT
AAAAGTITI'G
TATAGATAT'
TTATTTAAAT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1152 INFORMATION FOR SEQ ID NO:1392: SEQUENCE CHARACTERISTICS: LENGTH: 555 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .555 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1392
TTAGTCATGT
TTTTrTTTCA
TI'AAGCAATA
GCCCCCTTAA
ATACTCAAAA
CTGTTGCTT'ri
GCTI'CTCTGA
GGCGTGATCG
TTAGATTCT
'rTATATCTTC
AAAATAAGCC
TCGCTTTGAA
GCCCCTITAG
AGCCCCCTIT
TGACAGATAT
TTTITTAGCGC
CTTTAGTGGC
TATTGGATTl'
TTCTTACACG
ATTGGGTTTG
AGACTCCCTA
CTGTCT M
AGAAACCTI'G
TFI'AGGGTTI'
GCTTTTTTGC
CTGAGTITTG
AGGTI'CGC
TCGCTCAATG
ATCCTTGCFI'
CAATCTTATA
ITGCCTTTTT
AGCAGTTGT
TATGGCTTIT
TCTCTI'TGAT
AATTTAAG
ATGCAAGCTI'
GCGTCATGCT
CAATCTACCA
F1TTGAGTAG
TGCGTI'CTAA
TTITTAAGAC
TTTAATFFI'C
AAGCGTGT
CAGTTrACA
TTCTI'GCCAT
GTTTCAAT
TCA'TrCATG
CCCCTTATTA
'1711CAAATC
TTTATATCTT
TT1'ATCCAGT TCGCTTTI'GA CCCATTXT CTTITTTGTCT GCTAAAAAAA GGTTA INFORMATION FOR SEQ ID NO:l393: SEQUENCE CHARACTERISTICS: LENGTH: 2946 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc_feature LOCATION .2946 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1393
AAAAGAATAC
TTGTTTGTGG
CACATACAAA
AACAAGCTTT
ACTAAAAAGC
GTGTCTI'AT
AATATCTTT
TCCCTAGAAG
AAAGTCCAAG
TGATTGTCA
TThAAAAACCA CCTCTTrCC
TTTGCCACCT
ATCCCATCGC
TAATGATG
TGATGAAGAA
CAGTATI'CAC
ATI'TAAAAAT
CTTTGGAAGT
GTrI'AGAAGT
TGAAAAACT
TTIGATGGGAA
ACGATAAAAA
TGGATGGCAA
AGCCCT1'AGT
TAGAATTAAA
AACGCCAATC
TI'AAGA'ITGA
7IrGGAAAA
GCTITATCGCC
AAGAAAACAT
TCTTTAGTC
TCGAAAACT
TGAGCGGGTT
TCTGATTI'G
TAAAGTCAAA
TAAATACGAG
TATCAAGCT
CGCCCACTAT
TGAACCCAGC
AATrAACACT
GCAAAAAAAT
TAACGCTTA
TrCTGTAGTr
CATTAAAATG
GTATCCAAGA
GTCATITCACA
GGCATrI'CTG
GATCTCTCTT
ATTAAAAATA
GAAATCAT
TAGAATTTC
AAAATCATCA
TCACCCAAAG
GCTGCAATT
TCTCCAATGA
TTAAAAACGT
ATCAAGGCTA
AAAGCCACT
GATAAAACCG
AAGTGTTTAA
AAACCCTTTC
AATTATACT'
CTITCTTCCA
TCCGTTATGG,
TAGACGATAA
CAGGAATCAA
ATTI1GCTTIT
CCAGGAAAAT
ATI'TGCAAGG
AAAGCCTAGC
GGATTTGA
ATITCACTCC
TGATI'AAGCC
AATTGA'l'I'T
TGTCATI'ATC
AAACGGCATI'
AAAACTCAAT
TCAAAAACCC
CA'FITGGGCG
AA.ATAAAGCC
AGGGGAATTT
TAAAGATGTI'
GGCGTTCAAT
GCTAACCGAT
GTTITTTAAAG
CAAGATCCAA
TAGCGAGTT
TTCAGTCGT
CAAAAACAAA
120 180 240 300 360 420 480 540 600 660 720 780 840 900
CAGCTCCTCA
GCCACTaFT
AATTATTATG
GATAAAATCA
ACCGCCCCCT
TATAATATCC
CAATACATCT
AAAATCGCTT
CAAGTCAATA
GATCCGCAAA
GAAAAFI'CAG
AAATTCACTA
TTTGAI'ITFT
GAATFI'AAAG
TCCCCCATI'A
TTTGTCAATA
GATGGATCGC
GTCTATACTC
CTTAATAACA
GGATTAT'CT
G 1-11CATTA
CGCATCCATG
CTTGATATTG
ATCATGGCGG
TATATCAACA
GCTCTTGAAG
TTCGCCCTCA
AGAAACCCTC
ATCACTAAAG
GCTGGCAATG
ACTATCAAGG
GGAAAAGGAG
ACCCAAGTAA
TICACGCCTA
TITAAA
TACAGCCCCA
CCAATrGTT
GCGATAGCAT
GCATGCCATC
TATITAGCGT
CCCTTTACAC
ACATAGACAC
TAGATTTAGG
CCAATAACAA
CTAACTFITAC
AAGTITTTAG
AAGATGTTT
CCAACCCCGA
ATAACGCCTA
TGGACTATAT
TI'GATTT
ATTTITGATTC
CAAGCAAAAG
TTGATTTGAG
CAAAAGAACG
GCGCCAAACA
CTAAAGATGT
TCGCTCAAGA
ATTTAGTGCA
CCAT'C'TCA
ATCAGGTT
TGCAAAACAT
ATI'TAGGGGC
AATA'FITAGG
GAATCATTGA
C'FrTGAGTAA
GTAAAATCAC
CT11'AGCGTC
TITGACATCAT
AAAAATCACT
AGAAGCCCCT
TAAGGATA
TAGCGCGGAT
TCAAGGCAGC
GcAAAGCGCT
GATCCACACG
TCAAAAAAAC
TATCAACATG
TTTGGATCTA
AAGAAAAATC
TTACGCCACA
TCACATACAA
TACTFIAAG
TGCCC'TAAAA
TGcTAAAGAT TrrTT CTFI'A
CATATCCATA
TAITGATGAT
APLAAGAAAAG
ACGCTATGAA
CGTGCTGATC
CGATAGGGTG
TGGGGCTI'G
AAAAGAT'TC
CAATGGCGAA
GGTCA.ATCTC
TAATGGCTAT
GTTAGAAAAA
AITAGACAAA
TGTCTTAAAT
CACTAACGTG
AGATATTATC
CGTGGATGAA
TATGAAACCA
AAGTTGGAGG
TTIGAGCGCTT
TTGAAGCTCA
GTTAATITGC
CAAATCAATT
CGCTATGCAA
CTTTCTTTGG
CGCTCTI'ATG
AAAAGCTTGC
ATAGACACCA
GGAGACACTC
TGGAGCGTGC
ATCAAAGATT
GACGGCTCT'
TTGAAAATCA
TTrGGCTCTA
AAAGTTAAGG
TTCTTGGATA
CCTAGCTCTA
AAAGCCCACA
TATAAAAAAA
AAAATTGATG
TATC'ITAAGG
GTAGAAGGAG
'ITGAAATI'CC
ATCAACACCA
CAAATCAAAA
ATTGATCT'G
AACAAATTAG
AAAATCCCTA
AATGTCAAAG
CAAGCGCCTT
GTCAAGAAAA
TGGAATIAAC
17 377 AAA.
ATAAAGTCGT
CTTTGCAATT
AAGAAGGCAC
TGGACATCGC
ACATGCTGGA
ATTCIT1'AGT
ATCCCAATAA
ATTCTATCAT
TTAAAGCCCA
TCAAAAGCCT
CACAACTCTT
TGAAAAAGAT
TAGAGGT1'C
ACCTCCCCAT
TCAATAAAGA
GGGATCAAAA
GTAAAATGCC
AAGAAATCCA
AAATI'ATCCC
TGCCTITI'CC
GCAATT1ATA
CTCATAXT
GCITATTCAC
AAAACACAAG
TITCCCTCCCT
CCGGCTCCGT
TCGGCAAAAC
ATTITAAACTT
TCGTGGGCTA
GCACGTTGGA
TTAAAATCTT
ACATI'GATTC
CGGCTCTI'AC
AACGACCCCT
TTTACCTTTG
CTTAAAAAAC
'TICTCGCTC
CCAAGAATAC
TTTAGACGCT
CCATAAAATC
CACTCAAGAA
TCAAGAGGGT
AAGCGAAGAT
GTCGTI'GAGT
ATI'AGAAGGC
CAAGCCCTAT
TACGAGCGAT
TI'ATAGGAGC
TGAAATTTCT
GGATATTACC
AGCTATTGCG
AGATGAAGAT
CATCTCTACA
TI'TAGAAAAT
AAACCCCATG
TAGCGGGGAT
GCTIATTGGG
CTTAAAGAAT
TAFI'GTCTFI'
TGTGTrTGGG
GCTTGATAT'
AGAAGTTTCC
TCTCGTTI'A
TAAGCCTAAA
ACGCCGTAT
AAAAGGAAA
960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1800 1860 1920 1980 2040 2100 2160 2220 2280 2340 2400 2460 2520 2580 2640 2700 2760 2820 2880 2940 2946 an.
a a a.
a a a a.
INFORMATION FOR SEQ ID NO:1394: i)SEQUENCE CHARACTERISTICS: LENGTH: 1113 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM:-Helicobacter pylori (ix) FEATURE: NAME/KEY misc-feature LOCATION .1113 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1394 AGACCAT1CA
TTAGAGTGCG
ATAGACGCCC
AGCGAAcCTT
CCAATCACCC
GATCGCTTAT
TTATTACT'G
ACTrGCATGT 'TrAGCGCCC
TAGAATATGA
AAGGATTACC
GGAGGCAATI
GCGAGAAAAC
AGTGATCATG
AGAAGAAAT'
CACGCCCCAA
AACAGCATGG
GCGCTTTAA
CCCAATCTCA
TTAAAAAAT
AACTAAAACC CTCAI'CGCA AAATCACGCT TITGACCCC AAGCGGTGTI' GGAATA'ITCT GTAAGCCTI' GATTGACACT CTTCAAACTT CAAGCCTTTA
ATGAGTFI'GT
GGC-ATIAAAT
TCGGATTTGT
ATITTTATGCG
AGCGTTFI'AG
AGcGATTGGC
TTACACCATA
TTTCAA
AAAGCCCACC
CATAGCGCTA
GAACTTITG
AAAAAAATCT
TTTATAGTCC
GAAACGCTAT
ATTAACGA
TITTTAAAACT
TGGGTGAAAA
TCCATGCAGA
AAACTITCGC
GCAGTATCGC
TCAGCATGAC
CCTTAATCAA
CTAAAATCTC
AcATCCCGGC
AAACACAA
ACGCGCTAGA
CTACGCACAC
TGGTI'TGACT
CTACCCCAAA
GACTI'GGAG
ACAAGCTGGG
CCTFI'CATI'C
T1'TGATI'GAA
TTTAGATGAC
AACCAAAAAA
TrTTTGGATCG
GGGCATCTTT
CGCTI'TAGAA
CAATTTACCC
GCTTTGCTTG
TTAGAAGAAT
GGCATGACCA
GTTTTAGAAA
TTTTGTrrGG cCTAAACTCA
AAGCATGACA
TTATI'AGGGG
GACCAAGAAA
GACAGTGCCC
TCTGCCCCTA
AATTTGCAAG
AGTAAAAAAG
AATGAAAAAA
GCC
TGCAACGAGC
CAAACGCGCA
ACGCCCAAAA
ATAAAGAATI'
AAATCATTAT
ACCTCTATGC
GGAG'FTTGGA
GGCTCTTATC
CGCATI'TCAT
TTI'TGTTGCC
CCI'TATCAG
CGCATTTGTC
TCGCTATCTT
TAAAAACAAA
AAATGGCACT
ATI'AGGCTTT
TTI'ATGCCAT
AGAGCXTIG
GAC'FTrGACC
CCCGCATGT
CCT1'GCTTA
'ITCTAAAAAG
TGCGT1'GTGC
TGATAACGCT
TAAAAAACCC
AAGAGGGGGC
360 420 480 540 600 660 720 780 840 900 960 1020 1080 1113 cTrGGAACCT TCAAGAAATC
S
INFORMATION FOR SEQ ID NO:1395: SEQUENCE CHARACTERISTICS: LENGTH: 693 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 693 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1395
SI
GAAAITTTATA
CCTGTGGATC
TGGT'GATI'T
GTTAAATTAA
AAAAACAACC
CCCACACCCC
AAACCAAAGC
GTGGAAAXAG
GAACAAAAAG
CCTAACCAGC
GGCTTGGATA
TTAGGCACAG
TGCCGGAAAA
ATTCTAACAG
ATITTTTAT1'
ATCCTGAAAA
CAGGCGCTCC
CCACTCCGCC
CCAAACCAGA
TGGAAGAGAA
TAGAGCAGAA
'TTCTTTCTT
ACCAGACTAG
CCCGAAAAAG
TICTAAACTA
GAATTFTC
TGAACACAGA
TTTATTGGTr
TAAACCCACG
AACCCCACCA
ACCCAAAAAG
AAAAGTAGTA
AAAAATAGAA
GCCTAAAGAA
AAGGGATATT
ATFI'CATCAG
CAACCTGCTA
ITITCTCTCA
GAAGATFTT
1'TAAAAAGAG
CTAGCTGGCC
AAACCTATAG
CCCAACCACA
GAGGAGAAAA
GAGAAAAAAC
GTI'GCGCCAC
GATGAATTGT
GAA
AGTTAGGGAA
TTCTGTCTGT
TrCCTTCAAA
GCCATTCACA
CTCAAAAACC
AAAAGCCAAA
AACATAAGGC
AAGAAGAGAA
CTGTCAAAAA
CCAGACAGGA
ATGGCGAAGA
AAATrTTTGAC
ATTGTTACAC
ACCCAAGCTC
AGATCCCAGT
CCCCACACCC
GCCTGAGCCT
GCTCAAAAAA
AAAAGTAGTA
AGAATrIGAC
AAACAATAAA
ATTTGGAGAT
INFORMATION FOR SEQ ID NO:1396: SEQUENCE CHARACTERISTICS: LENGTH: 618 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE:.
NAME/KEY: misc_feature LOCATION 618 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1396 AGTCGTI'ATC
ACCCAAGAGG
GCTACAGGCA
CCGATAATGT
AACGTGAGCG CTTATTCTAC TTGTI'GGGGA
GGATCAATGA
GATATTTTTA
CGCACATI'AG
GTIATI'GGTT
TAGGCAATAT
AAGGTGGTGT
ATTFFI'CCCC
GAATTGCTTA
AAACAAGCGG
GA TTT AATCG CTCTGAAAGA GGGCGTGGGG-
GCATTGTGAA
TATTACGCGA
GCGATGTG
TTTTAGCCAA
GGATATAAAA
CGAATCTGTA
TI'ACGATCGT
CGATATTAAA
CGGTAAAAGA
TAAAGATAAA
TATTATCAGC
ATI'GCAAAGC
TGAAAAGGAT
TTGCCTAAAC
AGCGCGAAAG
GCCCAGCACA
TATTGCAAAA
ATGGGGCTI'A
GTCGCCAAGC
AAAGAAGAAT
ATTCATGCCC
TTAAAAGATG
TCAAACTCAT
CTF1'AGGCAT
CTTI'AGCGTG
GCGGGGAATA
TTAAAGGAGG
TCGCTCAAGC
ACGAGCGCFI'
CCTTAAATGA
GGGCGATTTT
TTGCATCACC
AGAAGTCAAA
CGCGTTGTCT
TAGTCAAAGC
TCAATGGGGG
TrTCGGGGCA.
GAGTTTAGAG
AAGCACGCGC
AATCAATGTG
cAAAGATTTG 120 180 240 300 360 420 480 540 600 618 TTGGCTI'TAA. 'TITAGAAAC 9 9* *9*a *9 9 INFORMATION FOR SEQ ID NO:1397: SEQUENCE CHARACTERISTICS: LENGTH: 318 base-pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .318 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1397 *999 *999 .9 9*9 9 ATATTAGAGA ATITGAGGAT TTCGCCAGG cITTIGGAAA T1TTTATITTT TAGC.AAAGAG AAACTTATr TCATAGAAG GGGAGCAAGC TrAATGAAGT CGCAAGATCC TATCAAGACT TT1'CCTAATT ACGAATTTAT 'ITGGATAACT GATGGCATAG AAGCTCCAAG AAGCTI'ACAA ATCTGTAGAA
ATCTATAACT
ATAT'CAAAGG TGCAAAAA INFORMATION FOR SEQ ID No:1398: SEQUENCE CHARACTERISTICS: LENGTH: 357 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular
TGATACTAAA
CTAATTl'TA
TAGCTTTAA
GT1'GGCTAGA
TAAGCTATGT
AAATTTGATT
TACCATI'AGT
ATI'TGAAGCA
CGCTAAAAGC
GAATGATTT
120 180 240 300 318 (ii) MOLECULE TYPE: DNA (geflomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori ix) FEATURE: NAME/KEY: misc..feature LOCATION .357 (Xi) SEQUENCE DESCRIPTION: SEQ ID NO:139 8 TGGTGATGC TAATGGCAAT
TTIACCCCT
TCTATGAGT TATTCGCC.AA
TATGGGGTTG
GATTTAAATG ATTITGTITT
TCGTATAGAA
CGTAGCAGAA AGGCTATGGA
AAATCATCTT
TT1'AAAGAAC AAGTAGATAT TAGAGAATTr ACTAAAAAAT .FTGATTTGT
TATTTTTAGC
TATATTCTrA TTTTGAAAAT GAGCAAATTT
TTTGCAACAG
GTGGGGCTTG
ATAGCAATGC
ATCGGTCTTT
TTGTCCAAGC
GAGGATITAC
GCCAGGCTTT
AAAGAGAAAA
CTTATITITCA
GATGAAAAAG
AGACATrAAA
GAGAAAAAAT
TCAATAAAT
TGGAAATGAT
TAGAAC
9 9 9 99*9 9**9 9* *9 9 *99* 9* 9 9 INFORMATION FOR SEQ ID NO:139 9 SEQUENCE
CHARACTERISTICS:
LENGTH: 912 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular.
(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .912 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:139 9 CTTGTGATCA ATTCTAAAAC
CGGACTGCTC
GCTAGTFI'GA AGGATTTGGG TTTGAGCGCT4 GACACGCIT TTATGTCTAA
GAATTTGCAA'
GGGGTGAGCA TCACGCGCCC
CACTAATGAG
ACTFTAGAGC AAACCACAGA
GCCTAATAAG
CAAGCCATTA TAGACAGCCT
TAAAGAATFI
CTAGACGAAG ACACGCGCTA
TGACGCTGAC
GGCGATATTC GTGCCATTAG
ATCCTCTCT
GATAATG=G TAGAAAGCTT
GATGAAATAC
AGTITGGATG; AAGCTAAATr
ATCAAGTGCA
TTICTATG GG;AGCGATAG
CAAGGATATG
T'ITTCTAAAT TCAATCAAGT
CATCGCTAAC
ATITATGAAG ATTCCCTAGA
CAGAGACGCT
CAAGAGCTTT TAAAAACCCG
CTATAACATC
CAAATCTCTA AAGCCAATCA
AAAATICAAT
GCTAAAAAGA
AT
ACCATTAAGG
GGCATGGTGC
AAAGCGAGCG
GTCAATGATG'
CCTGCCAI'A
GTCAAAGCCT
ACTAAAATCG
AATAATGTGT
GGGCTTAGT1'
TTAAAT'CTA
GGGGGCAGAG
CTCATAGATG
AAAAGCCTGA
ATGGCGGAGC
TCCGTGCAAA
;CGAGGACGC TTTAGGCAAG k.ATCTTATGA
AGCTITCGCAA
rGATCAGCGG4
TCAGCGTGAG
ATAATGAGCT
CCGGGATTT
TCTrATAG
TAGACGATAA
ACCCTAAAGC
AAATCCACCA
GAGGGAACGC
CCAAAGACAA
GC?1'TGCCGC
TGATGATCGA
GTTAATATC
CAGAGACAAT
TATCCCTAAA
TAACGGCGTG
CGTGCATACG
GGGCGTGATG
GACTCAAGAT
AGAGGGCATT
TAAATTAAAG
AGAAAACGCT
TTATGATAGT
TCAAGCAGCG
120 180 240 300 360 420 480 540 600 660 720 780 840 900 912 INFORMATION FOR SEQ ID NO:l4 00 SEQUENCE
CHARACTERISTICS:
LENGTH: 387 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) H.YPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION .387 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1400 09
AGGAACATI'A
GAATCCCCGG
GCCAAACGCT
ACGGATATTT
GTGTATCTI'A
AATGACGCGA
AGGGAAATCC
TGCAATACGC
CAAAACTCAT
GTATIGAGAA
TCACGGAGTT
CAGGCTI'ATA*
GTAAGAT1'GA
A'ITC.AGATGA
TAACGCTTAT
TGAAATGCTTr
TGAAGACATI
G'ITGAATATI
CACCCATCAA
TTTGGTGTI'G
ACTCGCC
CAAGCCTACC
TATGAAGGGA
GAAAAGAAGA
TTAGACTATG
ATCAAAGTT
AATGTGGCTA
AGCATAACCG
TI'ITAAGATI'
TCTAITATAT
AAAAAGGG
TAACGCAAGC
GGGGGTI'GTT
AGTGAGTGTG
TTCTI'CGCAA
TAATAGGGTT
GAAAGTGGCG
CAATGTGGAA
AGAGGCATGG
4 99* so 9 INFORMATION FOR SEQ ID NO:1401: SEQUENCE CHARACTERISTICS: LENGTH: 249 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATUE: NAME/KEY: misc_feature LOCATION l. 249 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1402.
ITI'GATGATC TTATGGATC AAACTCACTI' CCATTTTATC CACGGGTAAC rrCCCCACTT TCAAATGGGC GFI'ACTCAAA GCGTrGAT1'A AGGACGATTT GGCTGGCCCA CAAGGGCGAC AATGATTTCT TrCATI'GGGT TI'GAATGCTC GTT=TT1AA TITIGGTI'A TATAGTTIT AAAAGTTGGC ACTATAGCGC
ATIGTTATA
CCCGGTAAAA
CCCCACATTA
CGCATTAAAA
TATAAGACTA
INFORMATION FOR SEQ ID NO:1402: SEQUENCE CHARACTERISTICS: LENGTH: 660 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .660 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1402
S
*0 9 S. .5 S
AAGCGAGACA
GAAACCATITC
CTAAAAATCT
CCCCITTATT
TTTATCAAAG
AAAGAGCTT
TITAATGGCA
ACCTTAGACG
GAGCAGTTTC
AATCTAAATG
TAGTGCATG,
AGAATGT'AA
CTAATATAAG
GTGAATGGAG
TGCATGAAAT
TAGGGAATT
TAGAGGACT1'
GAGGTTGA
CTTTTTACAG
ATTTGGATrT
GCGTTTGCTC
CGATTTATTA
CTTGTGTAAA
TTTrGAA.AAG
CATCTCTAT'
TGGTCAAAAA
TTTCAAATAC
TATTCCCCTA
CCAAGAAAAC
GATGGATAGC
TATGACGAAT
CAACCCCCAT,
cAAAAAGAAA
GCAGCAGTCA
CACGAGAATA
TTAACGAAA.
CTCACGCTCA
AAATGGGAAA.
TTGAGCCATT
ATTCCTGGTA
TTAAGGCCAA
AATGCGAAAG GGGCGTGTGA TGTI'ATGCGT
AATI'AAAAGA
AAAGCGGGAG
TTGGCGATGA
AAGAGGATIT
AGCAACCGCG
AAGCCCTTAA
ATI'ACCGCGC
ATGGATCCGT
AA'TTGATGT
AAGGAGGAAA
GTTITGATATA
AGACGATGCG
CGAGTTFG
TTACGGGCAA
TGCGAGCGAA
CCTAATAAGC
ATACAATTTA
GCGFI'ATAGC
TAGGGGGTTG
GAGCGGGGAC
AAGGCATTAT
120 180 240 300 360 420 480 540 600 660
V
.5
S
INFORMATION FOR SEQ ID NO:1403: SEQUENCE CHARACTERISTICS- LENGTH: 762 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1 .762 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1403
AGATTITAAGG
TGCCCCTTAA
AGTGATCCTA
TTAGCCCCAT
TTAAGGA
TCTITGATAT
ATI'AAGCCTT
ccTrTCAAGG
ATTAGGAATI!
GCATI'TATGA
TrrTTGGTGA
CCGCCTGTAA
CTAGAATITGT
TGAGCGCGGA
AACAACTCGT
CGTTGATTT
CCGCTAGG
TGACmT
ATATCGATAA
AATI'CATGCT
TGCCTAACCC
TAAGCGAGTT
TTGATATGGT
TGATITCTCT
GCGTFI'TTTC
TAGCGCTITA
AACCACCCTT
AGTGATGACG
CACGCAACAA
TATCATGGAA
AAAGATTTCT
TAAAAACACA
TAAAACCCCT
GAAAACAGCG
TATCAGCTCT
GCcTITTTAAA,
ATITITTAA
CCTAGCGTCA
AATGTCATCG
AGT?1'CACCC
ACCCCACCCA
CCTAGCTTGA
TACACCGAAG
CGAGAAAAAG
GATGATGTGA
TTCAAATCG
ATITAATG
ATIGGTGT
TTCTCATTI'G
ATCTCTCTT
CCTTACTCAC
GTTTGATCGT
CTCAAAT'CT
AAAAGGCTTA
CGITTGAAAA
ATCTAGCCCT
GCTI'GAGCGT
GCTTTTTACT
CGATGGGTAT
TTATTCTGGT
CCCTF1'AATA
AAACGCTCCT
GCT'FrrGGTl' GGTGTF1'TCT
AGTCTCGCTC
TGATACAGGG
AAGCACTCTG
TITTrI'AGG
TTAATCCCG
CTACT1'GCCT
GATGATGCTC
GGATGGGTT
120 180 240 300 360 420 480 540 600 660 720 AATTGA CCGAAAATTI' AGTGGCGAGT TTTAAAATGG TT INFORM4ATION FOR SEQ ID NO:14 04 SEQUENCE CHARACTERISTICS: LENGTH: 1842 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .1842 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1404 0
AAGTGGGGAA
GATCATCAAA
GAAGAAAAGG
GTGGAWICCA
AAAAAAATGC
AATACAGAAA
AAAGAAGATC
AACACTACAA
TACAGCCAGA
AGTITTTGAAC
AmTITTAG
CAAAAAGCCC
AATGAAGATT
TCATTCTIGC
TATATGAGTA
AAGAGTITITA
AGAACCTTAC
TGCTCGGCAA.
GCTGGGTTTG
AAATTACTCA
AAATACCGCT
TITTACCGGG GITACCCGTG
S.
ocee 0 6 0669 06 0 0 000 6 TCAcTATCAT
TGACTAAAGA
CCAATITAGA
rGCTI'GCGCT
AGCTCTCTCA
GCTTGAACAC
ACAACGAAAA
GCGCCCAAAG
ACACTI'ATAA
GGTTTATGrr
TITGAAGAAGG
TAGCGTCTT
CTTTAATI'GT
GGGTAGCGT'
TCCCTTTAAT
AAAACTATAA
GACTGCCTAT
TGCTGTmG AAT1'AAGCGT
TTCCCAGTTG
AAGCCGGGAC
AAAATGATGC
ATCTITCAAG
AGAATITAAA
CTATGGATI
TGGTGGTTTC
CTTTTIAGAG;1
TT'GTGATGTI
GGATCAAGTI
TGATTTACCG
T'rrTTTAGAA
GCGTAATTTA
CAACATGTGG
AGAATIGGGG
AGAGCTTTTA
CATCAAAGTC
AATCGCTAAA
GATTGATAAG
TATCATCTT
GTTTAAAATT
GGTGGGCGAT
GGTGTI'GTAT
TITACTAGAC
CACCGGTTT
CGAACGATTG
TTATGTGCTG
CATTTATATT
GTTTAAAGGA
CAGAATGGTC
'ITATATTTh
GGCTATGAAG
CGAAGCTAAA
,AAATAGCGTI
TGATTGGCGI1
TACITTGGGG.
GATAATCAGP
TTATATCCCI
TGTAGCGTAI
GATAAAATGG
GGCACI'ACG
AAAGGGCAAT
GCCTAAGCG
GATGAAGCCA
GTTGTGTGCG
TTAGACGAAA
CCATCTCAAA
TCAGTGATCA
ATITTAATGC
TCI'TGAGCT
UrrGAGCGATA
GGCATTATTG
TTTGGGA'r1 6 1
GGGATCTTGC
GGTI'GCTCAG
ATCACGCTTT
TI'TGTAGGCT
TTGGGGGCGG
CAGACTGAAT
TATTTCAGTA
GTGGGAGCGA
ACTTATAAAC
GAAGAAAAAT
GTAGGAAGAG
TrGAGCGTCT GTG1'TGTTTT
AAAGAAGTCA
7TGTI'TTGCAG 7TTATTCATC7I CAAATlTTTGG
AAGTGAGTT
CGCTCAATGA
ACAATCTCAT
CGCAGT1A
AGAAAGAAGG
TGCCAACAAG
TTGTCAGGCT
GITITAAAGA
GTGAAAACAA
ACCAGCGTTA
TFTrAATAGG
GTATI'AAAGA
GGGGAGTGGG
CTTTACTAGA
ATAAATTTGG
TGCCTGCTTA
TI'GTGATCGG
CGTITTTTCCC
TTGTGGCGTI'
CCT1'TATCAT
GATCCATAAA
CTTCACCACT
TCTCAATGTG
AGACACAAAT
GATCAACATC
CGCGAGATCC
TI'ATTCTCAA
GTCT1'TAAAA
ACAAAATGCG
TGGGATTI'C
AGGGGGAGTIG
AAATGTGGCT
AGCGACGGT
GACGACAGGC
TTTGCATGGG
CATGGCGACA
CTTTATGAGT
CTCTTCAAGT
AGTGATGGCC
GGAAATGCCC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1800 1842 TI'TACACCAA ATCGCTTTCT TITTGATCTG GTITATGTCC
TACCTCAAAA
CAATACCCTA
AAAAACGCTA
T1GGATAAAA
GTCTFI'AACC
GCTAAAGAGG
AAATCTGATG
TTATCGTGT
GAAGCTGGGG
AAGAAAGCTT
TAAAAGAATT
GCGGGGCGTA
CGCTI'GTAAC
CTITAGGGGA
GCGTGCCTAG
CGACCATI'AC
TCACAACCGT
TT
AAAAACCGAA
TTTAGAA.AAA
CGGTTrTATG
TCAAAACGAA
CGGGATCGCT
TTI
5
TGGTAGG
TGTAGCGTAT
GCGTITTTCCT TGATAGCTI' TTATGcGACI INFORMATION FOR SEQ ID NO:1405: SEQUENCE CHARACTERISTICS: LENGTH: 975 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION 1...975 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1405 ATGAAAAGAA TrTTAGTTTC CATAATTTGG AAAGGGTGGA TGGAGGAGCA
AGGAAGTTAG
CTCACTAAA
GCGCCAATCA
ATTAGAAACT CTACCGGTAT GGAGGCCCAG
GGCAVFITCTAA,
GCGCCCTATG TI'GAAATTGG ATCAGCGTAA
CTAAGGGTGG
ATCAACATCA TCACCAAAGG ACTITII'GGG GCAAGTCTGA AAAAGCTTAG
TTAATAACAT
AAGCATTTI'G GAATCCAAGC AGCCCTACGG
ATATTCAAAA
AAAATCACCG CTTITrTTTCA ATAGCCGCTT ACAATCAAAA AGAGCGAAGC
GATGGGGAGC
GGGGGATrI'C ACTT1'
TTTGGCTGTT
AGCTICAGGG
AAATTATATG
AAGCATTGAA
TGGAGCTGTG
TACGGGAATG
CACGGT1TATT
GGAGAGCGTG
CATTCCTACC
AAACGGGGGC
GCTTTTTAAC
TCAAGTCAAT
TTACATGTTA
ATATTATAGT
TI'GAGTCATA
GTGGCTAACG
GG'ITCTCGCA
GAAGCTrI'GC
CCTAGCATTT
ATTCTAGTCA
TTTCCTGTAA
CGTrATGGCC
AATTGGGAAA
-TrITCAATC
ACCTATTTAA
TGGCTCAAAG
GATI'CATTGT
TXITTCTTGA
GCGCGCATGC
ATAAAGAAGC
CGGTGATrI'C
AA.AATGTGCC
CCATTAGGGG
ATGGGAT1'CC
CCTTTCAGTC
CTAACGCTT
GTCAGGTGAG
AAAATTCTAA
GAACGGGGGG
GGCAAGGGTI'
ATCAAATCAA
CAGACCCTGG
CCAATAACGA
TGTCAAAACT
GCCT1-rAAGC
TAACAAGCAA
AGGCGTGCAT
GTITGGTGCT
TXITI'ATGTC
TGTGGATAGA
TGGCGGTGTG
CGAGAGGACC
AAACATTGAT
TATGATGAAT
TAGATACAAC
TGATAGCAAT
ATCTITAGGC
TAAAAGCGGG
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 975 TCGTITCAA, AACAACCGCC TGTGTATCAA AACTITI'G GGGACACGGA TAGGGTAGGG *5 INFORMATION FOR SEQ ID NO:1406: SEQUENCE CHARACTERISTICS: LENGTH: 2391 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOT HET ICAL: NO (iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori.
(ix) FEATURE: NAME/KEY: misc_feature LOCATION 1. .2391 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1406
AGACTAAAAC
CAAAAAGTIT
AACAACATTT
GGCATCCTCC
C ITACTG GT1'AAAAGGC
CAAATGTTAT
CAAACTATT
TAGGCTTGTA
GmTAGAGGG
AGCGCCAAAT
GTAAAATTGA
AGAGCGTAGG
TTTAGGGGTT
TGATGAGCAT
GGTTAGCTAC
GGCGTTAGAT
TTATAAACAA
ATGTTAGAAA
TTGCCTAAAA
TrTTTGCTCA
ACCCATTI'AA
TCTITAGAAA
AGCATTCAAT
AGCTTTTAAG
GCTATTCTAT
CTAAAAACGA
GCACAGAGCA
AAGTCGTGGC
CTGACTCTCA
CGCTATCAAA
GAGCGAAGAA
AAACTTAGTG
ATTGCAAGAT
GCGTCTTGG
ATACTTGCAA
120 180 240 300 360
GCGATCTTGA
GAAAGCACTC
AATAGAGAAA
AA~zAAGCTTAG TTGAATrTIT
GGGTATTTGA
CAAGAAAGCT
GAAAGGATCA
ATCT1'rICCA
AAGTTTAGCA
ACCAAACGAT
GAGGATTTAG
GGCGTTATAG
CATTI'AAACC
GAAAGGCAAA
AAAAATrI'GG AAcGCTAAAG
GGTAAAAGCA
CTF1'TAGCTT TAccATGACG
TTAGAATTT
GAAGCCTTAG
TACCCCAAAG
CAAIWIGGGCI
GCGTTCAAC1I AAAGACTThG
AACGACAGCC
TTAAACACT2
TTGGCCTTGC
AACATGGGGI
AATGTGCC7.
CAGGTTFI'A(
GGCTTGGGG!
GCGTTACAA,
ATcAGTTTGA
ACTCTTTGCA
ATTFI'AAGGA
AAATCCAGCT
ATGcAGAATA GcGATAGCTA F1'AATCAAAA CT1'CTATAGC
TAGAGCCTAT
TGTCTAATCT
TATCCATGCA
ACGCTCAAAC
AAAC'I TrGG
ACCGCI'GCG
ATTTAGGTTT
ATrATTCCCC
AAATTGCCAG
CGCTGATTAG
TTGACAGGAT
GCCAATCTT
TGCAATCCTT
AAGACATGAA
ATTTTAGTI"I
TGAG'ITTAGA
CCAACGCTrT
GGCTITAGC
GCTTTrTGG1
AAATCAACGC
AAGAcATTTI
SCTCTCATI'
r' TGAGCGAA6A(
;TCAAAAATC
r' GTTATTGAU k AAGACTACC AAATAAAGAA
GTGTATGAGAA
TGGcGTTTTG
GAGCATAAGAA
TA'ITCTCTCT
TATAAAGCGC
CAtAAAACTAT GCCCCCAAAC
T
TA'FrAATGGG TI'TGAACTCC
C
TATCGCTAGT
TCTATCACTT
AACCTATAAC CGCTTGATIG G GGTGGGAGCG cTITrATACC GAGCGTCAAT AAAACGCTGA
C
TGTI'AAAAAC
GAGCTATAG
AAAATTCGCC
CTAAACGTIC
CAGCTTAATT TTAGGGCTTr CTTGAAAGGG
GGGTATTT
TTTTAACC
TCTAAAGCCC
TAAGGCTAAT
TCATGGGGGA
TTTTTATTC AA'rTTCCACA AGTGAATGGG
CATACTTTAG
CTATTTAATG
ATGAGCGCTI
GCAAGGGTTG
TATI'CTTTCA
TAGTATCAAC cCCTrTTGTT TTTrGAGC
ATGTIGGATC
TGCGATTI'CT GGCGCGAT1"A GCTGGATTTI
AAAGAAACGC
GCCGTAITTTG
AATAACCCCC
TTTAAATGTG
ATAAACCTAG
CTATTACT1'G
TITTATAAGA
T TTTTAGAC
GAATTTAAAT
TTTAATCACG
CAAGCCAGGA
~CCAACTTAGC
GGGGTTAAAA
LGTATCCGCAA
AAAAACGCTA
TGAAATITCT TTTrTAGAAA r GGGTAACGGG
AGTTCCAACA
~AATCTTTAAT
TCAGATTCCA
CTACAGAGTGG
CGTGAGAAAC
TCAGTATTT
AAAATCTI'
,TTTTITTGCA
CT1'AAACTC
.TTTAAAACC
7TGAAAAAGA
CATI'AAAGC
LAGAGACGCC
TTTTTAAA
ATACCAAGA
M'TTCAAAGC
CATFIAAAGA
:cTITTTCCC rAGCGTGTTT k.TAGCCCTIT PccAAGAAGT 1TATAGGGGC
TAAAATACCA
CCGAATTTT
TAGAGCCTAA
'TGCCCCTTC
AGAGCCT1TP
TTAAAAGAAC
TTiTI'AACGC
ATGCGATCAC
TCTI'AGAAG;
CCTATGTGG1
AAGCTAATG(
ACGCCCATAC
GGGAAT1'GAj
ACACCCCTC'
TGATTGATGV
GTCATGTCAK
TITI'GAAGAI
TTTAGTITITA
cATGCACGCT
AGAAACTTA
TAAAGAGGTT
CCTAGTAGGG
TI'ATTTCATT
TI'ATGAGAGC
TTTGGATATT
AGAGAGGGCC
ATTAGTCAAA
CCCCAGTTTG
AAACTTAGTG
TGAACGCATC
GATGGTGTTT
GAGCGTGTi~ir
GAGCCATAAT
AA.CCGGAAGC
AAACATGCGC
*TAAAGGGcAT
TTTGCAGAAT
AAGGGATAAA
TGAGACCT1'A
CTCATCTAAC
Fr1'GAATGAC
CCAAAACCCT
GTCTAGGAAA
AAAcGATI'TG
CGTGGTGGTG
;Trrrl'TAAGc k ACACAATTTC r GTATGccAGG r GAGITGGAG k TAAAGTGAAA 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1800 1860 1920 1980 2040 2100 2160 2220 2280 2340 2391 INFrORIXTION FOR SEQ ID NO:1407: SEQUENCE
CHARACTERISTICS:
LENGTH: 1587 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: Circular (ii) M4OLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISN-Heicobacter pylori (ix) FEATURE: NAmE/KEY: misc~feature LOCATION .1587 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1407
AAAATGATTC
ATTAGCTCTI'
CATGAAGAAA
GGGTGTGGGG
GTGGAAGCGC
GTTTATTACG
rTAAAAGTTC
ATGTGGATTT
GGAGCGCGAG
CGAGCGGGGA
TTGAGAAATT
ATCATAAAGA
CATI'GATCGC
GAGGAAATCA
TITTAGCGTC
TAGCATIAAA
AGCCACCGA
AGATTACCAC
CTITIACAAA
GcTTCGAATT
AATCAAGTTA
TTTGTGATGG
'rrCAATATAG C1TTTTAGAAA
CGATAGATAT
ACATGGCT1'G
AAGGGITTTA
cGTTTGAAAA C= AGAGTA
TGGTGAGT'C
TGTAGAAGTC
TTGCCCTTI'
CTATTGCTT
ACITTCGTT
TGACAAAGGC
GTI'GTATCAA
120 180 240 300 360
GAAGAGCTT
GAGACCATCA
AATAAA.GGCT
GAGGATAAAA
GCTCAAGTGG
TCGCCCCAAA
GAACACATTT
F1'GCACCAGG
CATTTGCCCT
GCAGGGCGGA
GGGGTGATFI'
GAAACTTTAA
ATGGCGGGT1' TTAGGGT1TI'
ACGCTTTTGC
TTTTACCCCA
CCCAGTGG
TI'GGATrTAG
GACGCTTTAT
AATTTACCCC
T11'GAGCCGC rAAcGCCCcc AAGCGTT1'AA
TGAATAAGGA
CCTATTTGCG
TGGG'I'TTGG
ATAAGCY1Ir
ATAAACAAAA
CGGGTTTTAA
TGCTI'AAAAA
ATGCGGC2'TA
TGTTTGAAAA
AAAATTGGCT
cTTATCTTT TGAAAAACTr AAGCGCCTTr
AAACAGAAAA
AATITTTAGA
CGGTGGGTTA
GTCAAGAAAA
TAAAAAAAGG
CAACTCAAAG
G 1-1r.Lr171.1 GTrAGGCTTA
CAAATTGATT
CTITTTGGAT
AGGGCGCACC
TGATAAATCC
GCAGGTCATT
AAACGCCATA
AGGCGATCCA
TAAAGCGAGC
CAACCTAGAC
ATCGCGCCCC
AGACGATCCT
TTCCTTGCT'
GCATGTTTA
GCCTAATCGC
AAAATTGGTG
TATCCATAGT
ATTGGACGAC
GGGTFI'TGAA
AAATCCC
AATTATTTGC
TGCACGAATA
GAATTGGGCG
CGCATCATGT
TTAAAAGAAA
AGCTTGCTCT
GTAACAGAAG
GCCACGCTTG
GAAATCCTTT
TTGATGTTAG
CCAGCGGATA
ATAGCTI'TCA
TTAGAAAAAG
TTACAAAATG
GGGATTAGAG;
CCTCAAAAGT
ATCCGCTACC
GGGGTATTCT
CCTAAATTAG
AAGGAATTGC
AAAAAAGAGG
AAATTGATTA
TGCTAGGCAA
TCCCTATTTA
AAGCGGCCAA
ATGCCTATCA
GGTATI'GGA
GGACAGCTT
TGAGCTATGA
CTAAAGAGCA
TGATCGCTAA
TTGAATTTGT
ATAAGGCCCT
AATACAAGCC
AGCCAGTTTC
TCGCGCATGT
'FITIAGAAGA
TGCATAAAAA
TTGCGTTATT
GTITTGTI'GAT
GCTI'AGCATG;
CGGCATTGAA
GAGCGATAAA
TAGCCCTAGT
GTATATCAAT
TTTGGCTAA.A
TGTGATFI'TA
AACGCCATCG
TGGGGATAAG
AAGGAAAGGG
TCATCAGATT
TTAAGGCAC
TAAAGAAATG
CF1'AATCGCT
'TTCAGCCT
TTCTAGCATG
CAGAAGCCTA
ACAAGAATTT
ATI'AGATGCG
TI'TGCGCTAC
420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1587 INFORMATION FOR SEQ ID NO:1408: SEQUENCE CHARACTERISTICS: LENGTH: 1290 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .1290 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1408
CTAAGAGGGC
AT1'GAAGCTA
AGCGTTAGGG
GCCTTTAGGG
ACCGCTAATA
GTGTCCAGCT
GAATTAGAAA
CTCATTATI'G
ACGATTATGC
ACCAAAAAAA
GAGAGTAAAG
ATGGTGTTTG,
GCATGGACTC
GGGGAAT1'GA
TTTTCTGTTG
GAGACCGATG
TTGCACTTGC
ATGGCGAGCG
ACGGGCGAAT
ACAGGCGTAC
AAAAGATGAA
GCGATCCAGC
ATCATTACGC
ATATI'GACAG
ACACGCCTAG
AGCACGCCT'
AAAAATACAC
GTAAAGCGGC
GCGAAGACAA
A2'rIrl'TGCGT
AAATI'GACCC
CAGTGGGCGG
AACTCACCGG
TCAAAGTCT
CAGAGAATAA
ATGTCCCTGA
TGATGGCGAG
TGACTITQAG
F1ATATAGGC
TCCGGTCATG
GAGTGCTFI'A
GAAFFI'CAGC
GATCCCAGCT
CGAAAAAGAA
ANAGCCTAGC
CAGAGAAGCG
TTTAAAATAC
AGATAAAAAA
CTCTATCACG
CATAGATGAA
TGATGTGCT
GAGTTTGGGC
GTTGGATXAC
GAAAAAGAAA
GGGGGCTACG
CATTTTGTGC
CGGGGAAGT'
TCCATGCCCG GGCGTATTGT GTTTTAGATG AAATTGATAA
TTAGAGATCT
ATTGATTTGT
CCTTTAAGAG
GAGATCGCTA
GAAGTGGATA
GGCGTI'AGGG
CTAGAAGATA
GGCGGAAATG
CCTGATAACC
GAAAATAAAA
AAAATI'GAAG
GACGTGATGA
GAAACCI'AA
AAAGTGCTGA
CCTAAAGACG
GATAGGGCTA
TTACCCATAG
TAGACCCTGA
CGCAAGTGAT
ACAGAATGGA
AAAACTACCT
TTAGCCATGA
ATITACGAAG
ACCCGCACAA
AAGAAAACGA
TIAAAGAGTA
TCGGTATCGT
CGGTTAAGAT
AAGAATCCGC
AAGTGCCTAA
AAGTTTATAA
GCCCGAGCGC
TAAGAAGCGA
CCAAGGGCT'
GGTGGATCGA
GCAAAATATC
TTATCGCT
A1T1'ATCAGC
CATCCCCCAA
ATGTrI'GAAA
ACAGATCGCA
AAAAGGGCGG
AAAAAGAGGT
TTTAGAACGC
CAATGGCTTG
TAGAGGCAAG
CATI'ATTGCC
AATCCCTAGC
CGCTTACGAT
TGGGATCGCT
AGTGGCGATG
120 180 240 .300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 GGGGGTTGAA AGAAAAATTG ATCGCTGCT1' TTAAAGCCGG CATCAAAACC GCTCTCATTC CTGTCAAAAA
FTACGAAAGG
GATF1'AGACG AGATCCCTAC TGAAGTGCGA GAGAATTTAA ACATCGTI'GC
GGTGAAAAAC
ATCGCTGAAG TG'ITAGAAAA
AACCFI'GCTI'
INFORMATION FOR SEQ ID NO:1409: SEQUENCE
CHARACTERISTICS:
LENGTH: 816 base pairs TYPE: nucleic acid sTRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .816 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1409 1200 1260 1290 a
S
a- AAAAGATATA GAAAAACTGC
TCTCTTACGG
AGGGAATITr TTAAAAGCGT
TAGAGGGTT
CGCTFI'CAAA ACGCCTT1TT
AGGGTTAAGC
TATACGA TTTTGTCTTT
ATCGCCTATT
CATTACTTGC AAGCGCACAG
CGGTGAAATG
CTCATTGGCG CGA'ITAAGGA
TTFITTTAGAA
ACGCTI'GAAG AGGTGTCTAT
TGTGGTGGCG
ATCGCGTCAA AAATTIITGA
CGCAAAGCCC
ATCTTIAT TTTGGGGGT'
TGGCACGACT
GTGTTTIG ATATTAAGAT
CCAAGTGTTT
GTIITAAGAT GGATAGGCAC
'ITACGCGTT
AAGGTGTITA AACATTATTT TTGr.GTGTT1! CATGTGCTGA AATGGGCTTC
CACCTIATTT
AGCCTGTATG; GGAGCCGmT
CCCATTTTGT
CTTGACAATG
T1'GAACCTTC
GAATTGTTTT
TI'GTTGTTCG
GAAGCCTTGA
AATTAAAA
TrGGTGCTT
AGAGATITATG
r1AGTGTT
TTTGAAGATA
TTTTTrGATCC
TTATGGGTGT
ATGTGTIATA
GGTTT
GCGACAAGCT
TAGAATGAT
ACTACGCT'C
TGI'CAGTCT
TITTCCCTAA
A.AACAGACAT
TrrGTGAAAA
CGCATTTTAA
TATI'CGCTTT
AAGATI'CAAG
TITITACCAT
TTrTACGAG
CCAATCCGCA
GTCATI'AATG
TTTCCCCGAG
CAGCTTGAGT
TTITGTGTCT
CGCTCCTAAA
GACCTrAGGC
CTACCGCTCC
GGGTAAAGAA.
GCCTTTGGTG
CTTGTTGCAT
TCCCACGAAT
CG'TTCTTGG
CTI'ACTCATG
120 180 240 300 360 420 480 600 660 720 780 816 :*to.
69a INFORMATION FOR SEQ ID NO:1410: Wi SEQUENCE
CHARACTERISTICS:
LENGTH: 747 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: (A)'ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/ME: misc-feature LOCATION 1. .747 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:141O
GTAGGTGTTG
AGTGTGTTIAA
CAAAGTGCTG
GACAATAACC
ACCGTTFI'GA
CCAGAAACTT
GACTTTIAG
CAAAAAAATA
GAAGAATCCG
GCTAAGGATT
TTTGCTAAAG
AhATTCGGCA
CCTATAAAAG
TTATGATAAA
ATGCCAAAGA
AGATCAGAGC
TTAAGCTCGT
ACACTITTTGA
GGGATAAATT
AATACGCTAA
AGGCATICAC
TTTTGTTAAA
ATGcGATGT
ACGCTAAAAA
CAGAATGGAT
CATGGCAAAA
AAAGACCCT
ATGCGTTI'CG
C1-rGcAATTA
TAAAGACAAA
TTATGCGGGC
TGAAAAAGAA
TTCTAA.GGGC
2TTT1AAAAACG
GGAAAAAGGC
TTTAcAAGTG CAGcCAAGAA
TATTTTACCC
TAAAAAA
GCATCGGTT'
CCCATAACAA
CAAAGTTACA
AAGCCAGCCG
TAT'FTAGTCA
GGCTCTCTTA
GTTAAGATTT
CTCAAAAGCT
AAGCCTAAAG
GGCGACACTT
CAACAAGCCA
AACTCTCT1'
TATTAGGAT'
GAAGCGTTAA
AAATGGCGAA
TCATCTI'GGA
AAAACTGCAT
CGCTCATTCC
TTTACA'TTC
TI'AAGCTCCC
CCGTTAGGCG
TGCATGATT
AAGTCTTGCA
ATGGCACATG
GAGTTTGATG
GTATCATCAG
AATGGCGCTA
TTTAGATGAA
TAAATACACC
TGGAGCGCTA
TAACCGCACC
ccAAGTGAGT
GGAGTTAGTC
TGACGCCATI'
AAACGCTCAA
GGAAGATGGG
120 180 240 300 360 420 480 540 600 660 720 747 a a a at..
a INFORMATION FOR SEQ ID NO:1411: SEQUENCE
CHARACTERISTICS:
LENGTH: 1089 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .1089 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1411 a.
a a
CATGACAAAA
AAATGCAAAG
GATFI'TATT
GTAGAAGTGT
ccTTTCATTG
TCCACCGACG,
'17 GAGAAAAT
CAAAAGAGAG
GACTTAATCC
GCATGGAAGC
AATGITGATC
CCCGCTTC:GC
ATTCTTATrT
'ITCGCTCACC
TI'AAGCGTC7
CAATCTATCG
AACGAACAA'I
A.ITCAAAAAG.
CAAGAAAGA
AATTTGATCT
ACAAAGAAAA
TAGTGATTCC
ATTTGGGCGT
ATGAAGTTAT
CCCTTATCTT
CCATCCCTTA
TGCGCCAAAA
ATGCGTIG
'FTAAAGACAA
TATI'GTGGAT
ATFTTCATTGA
GCGGGCCAGG
TCTATGATAC
GTATCGGGAA
GGTTTACCC
TFFI'AGGCAT
AAAGCGAAAA
CTTAGGCGGA
CTCTCAAAAA
CGCTTTAATC
GGITGTGCCT
CATAGAAGAC
T1'1ATTTTCT
TATCCTAGCC
CCGCTCTTTA
TAAAGACTAC
ATCCAAAGAG
TGGCGTGCAT
GTTGATTGCA
CGAGAGAAAA
GAGCCATAGT
CGCTTCAGGC
TAACGAACTC
CACCCCGCCT
GATTATGGGA
GCTCTCAAGC
AGCTATACCA
AACCATTTAG
AATTTTAAAA
ccAAAGACCA
TGCTIAAAAA
GATCTCCCTA
CGATCCATCA
ATGCATAGCG
ATCTI'GCATG
GCCACAGAAG
TTAGTGGATI'
CCTTTGCATG
ACCGCCTCTA
AATGGCTCAA
TTTATCACAA
ATGcTrr
CCCCAATCGC
CCACCACCCC
ACGCCAAACT
AAATCTATTC
CCGAATACGA
ACGCTCAACT
TCGCTI'CAAA
GAGGCAGTIC
AAAAATTAAG
AACTCCTTAA
TAGCCAAATT
TGAACGCTIT
TTGCCAGATG
ACGATATGGG
AAAATCTTTC
GTCATGGATT TCGTAGGGTI' TGAAGA'FrrA
TAAGTTAGGC
AGAAAAAGGC
TTTAGAATTC
CAAAAACCGC
TGCrI'rCAGT
TTGGCTTTAT
ATACAATTTG
TAAAAAAATC
ACTCAACGCT
GCCcGTAT1'G
TI'GTGAGATC
AGAAGTCCCT
GTGCGCGAAT
ATTTGACAAC
GCGGCCTTTC
I'TTGATI'GAC
TCATCACATG
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1089 INFORMATION FOR SEQ ID NO:1412: SEQUENCE CHARACTERISTICS: LENGTH: 1986 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1986 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1412 S.
S
S
*SSS
a
GGTAACACGA
GACATCCCTC
TACACGCTTC
ATCGAACAAA
GCGAITTA
ACAGACAGCG
GATATTTATA
GTCTCTAAAG
ACGCTITTAG
GAGTTrI'ACG
TCTTTTATTG
ATTCCTITGC
TTATTGAAT
T1'TGAACGCG
CCAGCCTTI'
TGGACGATAG
CTCGCCATGG
GGGCAAGATG
AACGATTTGG
TCTCTAAAAA
ATTTTAGATA
TTG'TrAATA
CACAAAAACA
CTACAATCAA
GCTTTTCGTG
CAAGATATGG
ATI'GAAAAGA
GCAGAAAAAA
GATTTCAAGA
TCCAATAAAT
TCAGGGATCG
GCTAA'ITTAA
CGAGATAATG
ATCAGC
TTATAAAGAT
ATATI'GGCCA
AAGGCGAAGA
GTGCGAGACT
AAAACCAGTG
AGCATCAAAA
AAGGCACTIA
TGGATAATAC
AAGAAGAGAG
CTAAAAACCC
AGCAGGGTFI'
CTAAAAAGAT
ATGCGAGCGC
CTAGGCATAT
TGATGAGTT
AGGGCGTGAA
AGTATGGGAT
GGGAT1"ITTC GGAATrGTT
GCACCAAAAT
ACGCTAATIC
TTTATGATII'
ACGAATCAGA
GCTI'CTTGCT
TAGAAATCAC
TTTTACAAGA
TTGAAAAGAT
AAGAAAAAGA
AAGTAGAGAI
TACTGCGCT7
CTTTGGATTIA
*AACCCGCAAA
*ATAATCTGGC
GCAAAAATCA
TGCTTATACG
AGTCTTTTT
GAGGAATCAA
GGAITTrI'C
ATGCGTGCAA
TAGCGGGTAT
AGATAGTAAA
TTATITTI'C
TGAAGCGATT
ATTGGATCTG
GAACGATCCT
GTTAGGGTAT
TGTGGGTAAG
GAATTTGCCC
AATGAGTAAG
TGAAGAATI'A
TAAAAAAGCG
GAATCGTI'TG
CACTGCGTAT
TTTTGTGCCT
TTTGAATAAA
AAAATTAGAA
CTATGCGT1'C
GCCCAATAAT
CACCGAGCCT
TGAAAAGATI
AAAAGCCCCA
TAAAGTGGGG
AAAAGTGGA'I
TGAGCCTGAM
GCTTATGGG'I
1'TTAATCAGC
CTGATCACAA
ACTITGATTG
TTAACCGGCA
AGCCCCAAAG
AATITAGATT
AACGCCTIT
TATI'GCGTGA
GTCCTATGCC
AAATTGAGTG
TI'GCCCATFI'
TCTATCACGC
AAGCATGTGG
TTGAACGGT'
GATATTTTAC
TTATTCAAAC
AGCTTGGGTA
CGCTATTT
'ITAGTAGAAC
CTAGGCATGG
TATCCTAAAG
AAAATGCAA~t
CTCATCGCTA
GCCT1'ATTGA
ATGCCAAAGA
TACGAACGCT
*TI'AZTI'CA
GAIAAAGGG
*CCAACACAAG
CTTATCAAAG
TTAGGCGAA
AGCTIGGTGG
GAAATGAGTG
CCTACCAGAG
CCCCCATI'A
CGGACACTT
CCGACGAGCA
CTI'ACGCCGA
ATGATGGTT'
AAATCATGT
GCTGTGAGAG
CTGATTGCTT
CGTATGAAAA
ATCGTWAA
GCACGAGCTI'
TGTATGTTI'G
TAGACAATAA
GCTTCCATGC
AGCTCTGTGT
ATGTTTTAGA
TATI'GCGTGA
GGATTAATGC
CTAAAAAGTA
AGCTAGAAAA
TGCATAAGGC
AAGAAGAGCC
GTTTIGATCGC
GCGCTATGAA
TTI!AAGGC
AAATTGAGAA
AGGAAGCCCT
AAAATTATAT
AAGCTCAAAG
ATCGTTTGAG
GTCAAATGG7 AGGGCATGA7
AAAAAATTGC
TTATGTGAAT
AAAGAAGTAT
TGGGCAAAAG
TAGCATTAGC
TATCCGCACC
TGAAAAAGGG
TTATTGCGCG
GAGAGAGACC
GCCTT1ATTG
CGAGGTAACT
TGAATGGGGT
GCTGGACGCT
AATGGCGCAT
CATII'ATTGG
GCATGGGTGG
CGCTCAAAAG
GGTGCCTI
GAATTI'GAAT
TTTCAATTAT
AGCACATCAA
TTTAGAGGAA
GTGGGTCTTG
AAACACGCTA
ATTAGCGAGC
TAAAAAATTA
AATI'GAAAAG
AGCAGAAAAA
TAGTATI'GAG
GATrGAAAAA
GCAGATCATC
GTGCGTGGTG
'ITTAGCGGTG
AGGAAGTTTG
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1800 1860 1920 1980 1986 INFORMATION FOR SEQ ID, NO:1413: SEQUENCE CHARACTERISTICS: LENGTH: 1026 base pairs (B)TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1..-1026 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1413 a.
a a
GGACGCATGA
A'ITGAGGGAG
AAAGACAAAC
ACGCAAGATT
TCCATTIACT
CATAGCGGGG
AGGCCTGCTA
GCAGGAGCGA
GAATACGCTA
GAAGAAGATA
GACT17T7"T1I'
GTITGCGATG
ATAGGCTCTA
ATGCTI'AAGA
GCACCGCTTT
GCGGTI'GAAT
ATI'ACTCAAG
GACGCT
TGAAAATTGT
TCTCAAGGGC
CGACCCC=r1
ACATTAAAT
TGGGCATGGA
CGACTATGGG
'ITTGCACT?'..
ACACGGATTG
AAAGCGTGTI
TTAAGGGGAA
ATGGCAATGT
GCITI'ATGGG
TITI'TAAAGA
ACGCGTTTGG
TGGGCGTGAA
GCGCGATITA
CGTI'TGAGAG
AATAGACTA
TTTAGAGAAT
TATTTCTAAA
GGAAGAAGCC
TATITI'AAAA
TI'AGCGACC
AATCCCTAC
CAAGCCTGAA
GCATI'ATGAC
TACGCTCGTI'
GGAGGGGAC
GAATGTGGTC
TGAAATTAAA
TATTTTAAAA
TAAAAGCGTG
TCAGGCTATI'
TITTGAAATCT
ATGGGGGCTG,
AAGAGTITTA
GAGTIAGCCA
GCCACTGAGG
AATGGGGCTG
TIGCGTTTAG,
GTTGGCAAAC
TATrI'GATTG
AGCCCTAAAG
AAAGAAACGC
GATATTTICA
ITAAAGACAA
AGCTCTITA
CAAAAAACCG
ATCATTACCC
AGCGCTGTTG
CAATCTTTG
ACCATGGGGT
GCGTGGFFF1'
GCAAAGTCGA
CGAI'AAGCG
ACGC'I=GAT
GGCGTATCAA
GCCCTAGCGT
ATI'ITGCTCT
TGGGTCTTI
ATAAAATGTT
AAGGGGTTGT
CTGAAGGGGT
AATCTAAAAT
ATI'ACGCTGA
ATGGCAAGAG
AAAGTCAGGT
AGAGCCAAAG
TITACCCATr
AGTGGGGGAT
AATGATCCAC
TAAGGAATCT
TTCAGCGGGG
GGGGGTTGAA
GCTATTAGAC
CATGGOGTAT
GAGTAATGGT
GAAAGCITAT
GGATGTAGTG
CGCTAGTGCG
GGGGGCTII'G
ATATGGGGGA
CAACOCTAGA
TG TGAGG
CGATCAACAA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1026 a INFORMATION FOR SEQ ID NO:1414: SEQUENCE CHARACTERISTICS: LENGTH: 759 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KFX: misc-feature LOCATION1 759 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1414
AACGCTCATG
AGAAAAGACA
TATGAAAACA
GAAGTI'TCAC
CCCAAAGAAT
ATCGGTGGGC
GGAGGGTTIT
ATGAGCGCGG
CCWI'TACCCA
ACACCTTGCC
ACAAGCCTGT
AAAAGCATTT
ATTTGCATGA
CTCAAGGCGA
GCCCGCATGG
CTTATGCGGC
TCCA TI'AGC
TI'FFFTAAGG
AAGCGTTGAT
AAAAGAAGCG
CAATATCAAG
TGCGGGTr TG
AGGGGGAGCG
CCGCTATGTG
GCACCAGCTC
CCTGATGGCA
ACGATTGTCA
GTGATTGAAG
vMIT ITATAA
ACAGGTAGAA
ITTACCGGGA
GCTAAAAATT
ATGGGGTGA
GCITI'CGCCT
AGTCTCAAGT
ITTCCACCCA
AGATCGTGTA
ACCCTACAGG
AAATCATCTG
AAGACCCTTA
TGGTAGCGAG
TAGAGCCTT
AGCTCAAAAA
GAGCGTGCGT
ACATTCCCCA
TAAGGT2TrTA
AAAATICGTC
GGATACTTAT
CAAGGTGGAT
CGGGGTTTGC
GTCTATI'AT GATAAAGCGA CCCTGCAGCT TGCTTATGCG GTGAACACGC ATAACACGAG CAAGCA'ITCA AGCGCGGAGT GIT CAAAC TCACGCCAAA AGGCATCATT GAAAGCTI'GG TCGCTCACTI? CAGCTTATGG GCATTITGGG CGCGAGTTAG ACTAACAAGG TI'GAAGAGAT TAAAGCG'ITC TTTAAGCGT TGGAAAAATG CGTGAAATCG ATTTGTTAAG ACCCATrTAT AAGAATTCAC F1'GGGAAAAG INFORMATION FOR SEQ ID NO:1415: SEQUENCE CHARACTERISTICS: LENGTH: 435 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .435 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1415 S S 9t 9 9*
S
S. S 9**S 9 *9
S
TCAACAATTC
GCACTTAAGA
GTGGTGGCCA
CTCAGAGAGA,
GTTATGGTTT
GATCCCAAAC
.AATGCGGTGC
GCCGCTAGAG
ACAAGGAGTT TAAATrGAAA A.AAAAGTGGT AGGCAAAACC TGAAACGCTI' GCATI'TGAGC GACCCTITT TAAAGATTTLG TAGAAGGCAA AGATGCGGTG TCGCCCAAAA AGGTACTATC ATGGGAGCGA TAGCI'GGAA
AGITTT
CAAAGAACGC
ATI'GATCGCT
GTGAAAGACG
ATAGAGTTTA
GCTAAAAACA
AGAGCGGATI
AACGCGCACA
TGTCTATTAT
TTGAGAGTAA
CTGAAAACTT
TGGTGAGTGG
GAGAGCTITAT
TTGCTGAGAG
ATGAAATCGC
TAAACCGGAT
CGGCTI'GGAA
TATGCGATC
TCCGGTGGTG
GGGAGCGACT
CATIGACGCT
TI'TCTr~iTFF
S.
S S INFORMATION FOR SEQ ID NO:l416: SEQUENCE CHARACTERISTICS: LENGTH: 579 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1. 579 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1416 GGGCGAGGT GAATTTATAT TGAACATGGC AGGGTTAAAA TGGTAGCTTT AAGCAACGCT C TTCAAGGG TTITGGTC TGTGGCTGGC TATAAAT'CC CTTCTrAT CCAAAAAAGC ATCAACGCTC TITATGTTIAA GATCTTTAAA ATI'GA'TITGA GCGAGTGA GCCTITAGAA
AATI'ATAAGA
AAAGCCCCTA
GACAACGATA
GAAATCAACC
TACCACCACT
AAATTACTAC
GAAAGGGTCG
GTTTGAACGC
ATATITGCAT
GCGCTrI'ACA
CCTI'AAGCCC
ACCACGCCCC
CAGTCAATAA
CGCTTGT'GC
TCTTTTCATG
TGCGCCTTGC
AATTAAAGGC
TTCTTITC
TrGCGAT'TA GCcTCATTA
AAAAGACGAT
CGCTC TTT AA AAAAAGAACG GATGCTFAA
TCACTGAATG
ATGCCCTATA AAGCGCATGA TATGTGAATI'
TTTACC'TTTC
GAAATTAG AGGCTCGTTA CACAAAAACA AAAATCTGTT
TCAAGGCAA
CCCCTFI'GAC
CGCTrITI'A
ATTAGTGCGC
GCCCAAAGAT
TTTTGCGGGG
TGTGGGCAAT
240 300 360 420 480 540 579 INFORMATION FOR SEQ ID NO:141 7 SEQUENCE
CHARACTERISTICS:
WA LENGTH: 720 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAM/KEY: misc_feature LOCATION .720 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1417 a. *a a
AACCATAATA
ATTGATAAGG
AAAGGCATGG
ATCAACCCTT
TATrICAAGC
CCCATI'GCAG
TI'AGGGGTGA
.r'ATAAAG
AATCTTTCAA.
TATCATGGGG
GAGCAGATTT
GGCTATTTGG
AAGGGGCGGA
ATAACCCAAG
TCATTTTTAG
TAGCTTTCAA
GC ICTI'C
GAAGCGTGGC
TGTTGTGGGT
AAAGGGGCTT
GGCTCTCGCA
GGCTTlTTGC
TAGTGGCCAG,
GGGTGGTGTT
AATTTCGCTA
GACGAAAAAC
CGTI'TCAAAC
GcTfl'CGTTA
TTTGGCGCAT
GG'FrrTAGGG GGCTGGGF11
GTTTTCCAT
ccTI'GTGGCA
GTATTTGGGC
AGATI'ATAAA
TTTTATTT
TGGGGTTTAA
CGCCCGAGCG
GCTATTTTGT
CCTTrTAA
TTTGTCGTGG
GATATTCCT
GATITGCTCT
CCTAGCCAAt
CTGATCTGCT
TTAGGGGTTT
AACATrCCTA
ATCGTCCI'G
CCCGCTTGGT
TGGATGGTAG
TI'GTGGGATG
TCATTIAGG
GTI'IGGCTTT
TATGGAATGT
ATI'CTITACA
TAGGGGAAAA
GGCTGTTT
CAGCCT1'GAT
AAGCCTTITT
ATGTGGGGTT
GGATAGAGAC
GATCAGCGTr
GAGTAATT'C
GGGGTATTCG
GGGTF1'AGCC CTrTrGGCT
GGATATGGAG
ATGGTGCTIG;
TGTGAAATGC
cTTACTcTAT
TGTGAGTAAT
CAAGCATGCA
120 180 240 300 360 420 480 540 600 660 720 S S
S
INFORMATION FOR SEQ ID NO:1418: SEQUENCE CHARACTERISTICS: LENGTH: 552 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .552 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1418 GTAATGGCTA TFI'GGGGGTG ATGCATGAGT TGGTTI'TAAG GATTI'ATCGT TTCTTATGA GAAGA7A1'TG AT1'GGTTAAA ACTCTGGAAT
TACTCAAAGC
AAAGAAAAT
TACTTGAATI'
GTTTGCCTA~A AAAAACAAAG GAG GGG AAAA TCCTAGCCTI CGCATGCACG
CCTTAGACAT
GGcTTGA.AAT TA GTGTTrTTA
ATCCCAAGCT
AAGGTTTATT
TTCTGGCTTZ
GcTGTATTTT GGAGcAAAAG
CCTGATAGCG
TTTTGGCGTG
TAAGCGTTAT
TTTI'ATCGT
TTAGGGTTTG
TCTAAAACCA
GXTTTI'CAC
AAATTAGAAA
GATCGCATCA
CCTCAAACTT
GCAAGGGATA
GATTCCTI'CA
CCT1'GATGTG
AAACGCGCT
AACGCTCTTT
GCTTGAACGT
A ATTAGAGAG TCGCTITrAGG
ACTATGGGCG
AAGA'TTI'T
TTGTTGATAG
GGGTTCAAGC
AGTCCAGTGC
AGCGGTGTI'A
TGAAAATGAC
CCTGC'TrTA
GCATGGGCTA
TTGCGTGTTA
AGAAATCACT
CGAAAGAAAA
120 180 240 300 360 420 480 540 552 S. S S
S
S S *5*S INFOP1MATION FOR SEQ ID NO:1419: SEQUENCE CHARACTERISTICS: LENGTH: 345 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NME/ KEY misc_feature LOCATION .345 (xi) SEQUENCE DESCRIPTION:. SEQ ID NO:1419 *5
S
S
AcGGGAGCAA TCATGITATC TI'GGTGTTGG
TGTGCTTGGT
ATGAGGCGTT TAGAAAAAAC CGTTTGAGAG,
AATTAGAGGG
GACAGCTCAT
TAAAAACGAC
TCCATGGATA
AAGAGCGCGA
TTCTAXTGAT
GGGGTA'IITG
TrIAGATGAA
GCGTTTGGAA
TCTI'TCGCAC
TI'ACTTAGAA
TTIGTTI'ATGG
TATCTTAAAG
TCCTATCAAG
GGCCTTTCT
CTTTATAACC
GAAAAAATCA
TCGTF1I'AGG
AAAAAGAGTI'
AAAAT1TATCT
TAGAAAAAAG
AGTTGCAAGA
TTACT
GGCGAI'ITTA
T1'ACCATAAA
CTATI'CTAAG
CGCTAAAGAG
AATCCAAAAA
120 180 240 300 345 INFORMATION FOR SEQ ID NO:1420: SEQUENCE CHARACTERISTICS: LENGTH: 1005 base pairs TYPE: nuc-leic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geriomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE:' NAME/KEY: misc-feature LOCATION 1 1005 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1420
GAGCCCATTA
ATACAAGGCG
TATATCAGCA
GTAGCCATAG
GCTACAGGCG
AATI'CTGACA
GGTGAAAAGG
GTTAAAGAGG
CCTAACAATA
TTTAGACA
CGCTTGCGCG
CGTIGCGCCA
CAAATCCTTA
ACCAGAGT'C
AAGCGGTATT
GCGGCGTTTC
GAGATTGAAA
AAAGCGACAA
TATCACACAT
AAGGGTATCG
GTI'TAGAGT'
TGCAATTAAA
ACCAGAATCG
ATTTGAATGA
GAGAGCGCGA
TACAAGGTCT
GAGATCAITA
TTAAAGATCT
GAGATFIGA
TCAGCTACTT
ITTATTCTTT
TGGGCAAGAG
TTGTGCGTA.A
AATTAGCAAC
AGAAGCCTT
TAA.GAATAkT
CATTGAAGAG
GGGCGAAGAC
AGGGCTGGAT
TCTTTATAAT
TTTCATCAAA
AGTGTATTAC
TATGAGCGAT
TITTTI'ACAT
CGTAAAAATC
AGAAGGCAAA
CGTGCGCCGA
ATACAGACAG
CGTTGGTCAA
CGCTTATGCA
GCTGAACCGC
GATCTGCTCA
TATAAATTTI'
ATTTATGGCG
GATCCGCAAG
CTCATCCGCA
ACTTATTGGG
ACCTATTTGA
GCGCTAAAAG
ATGCGAGA.AT
CGTGGAGACC
AAATrI'GGCG
TTGGATI'ATG
AGCGTGTGCG
CTAGGGGAAG
ATGGCGTI'CC
GCAAATCAAG
CAAAAGAAGA
TGCAAAATCG ATCGCATGAA
TCACCAAAGA
CGTTTTGTG
TGGTGITTTGA
ACTATI'TGAT
TGCCTTI'AGA.
GAATCTA'TT
CCCACCACAG
ATGGCAGAAT
CGCAACAGI'
TGGCAAAGCC
AAAACTTCCA
GGGATTCTAC
ATGTTTCAGC
CTAATGACGA
TGTGCAAAT1'
GAATI'
GCTTGACAAT
GCTCAAAATC
GAGCATCAAC
GATGGGGGAA
AAATTGGCTT
TGAGGATAGA
AGACAATTTC
CTTTCAAATC
AGCGAXTI'A
CTrI'GTFF'G
TGAAATCTTG
CCCTACGCTT
CGATGCATTG
TAAAATTAAA
CATCCTGCT'
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1005 S S INFORMATION FOR SEQ ID NO:1421: Wi SEQUENCE CHARACTERISTICS: LENGTH: 282 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genoraic) iiii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .282 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1421
TTCTATGTCT
GGTGCCCG
'ITAATGTGG
GATCAATGGG
ATCTFTTC
CGATCAITAA
CCCTTGGGGT
GGGCATACGC
ATICAAGCTI'
AAGCGCTCA.A
ATGCACCCCT
CTATATGGAT
TTCAGAGACT
GAGTTI'GGGC
AGTCGCCACG
T1'ATTGGTCC AAATCGTAAT CCAATCCCGG CAGGCATI'AT TTGA GGG CGA GC'TrCTITC TGAATTACT TGCAAACCTI' GCCAAGCCTA AG
CGTGTTTTAT
TGCGTI'TCT
TGTCCCTAAA
TI'GGCATGTC
INFOMATION FOR SEQ ID NO: 1422: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 1383 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAmE/xEY: misc-feature LOCATION 1 12383 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1422 S S S. 55
S
5
S
a a. .p a a 9
TCAATAAAAC
ACTTTAGAAT
T1TrTCCCAA
GCAGG'ITATC
GGTCGTAAAA
GCTTTGATGC
CCTAAAAACG
TGTCAAGGCG
GCCCCACAAG
ATITITGCTTG
GAAGATITGGG
TATTrGAGGC
TI'AGTCAAAT
ATGCTTATCA
mTACCCTTA
CTAGGACTTG
.AAACCGCACA
NAAGGAAT
GCTTGCTTT
GCTAGAATCC
GGCTI'TACCC
TTGCAAAGT
TCGCTTI'AA.
GCA
ATTTAGGCAA
TTTACGATIT
ACACGCTTAG
TGGCGCGCCC
ACATGTTCAT
CAACTTITAA
CTCATI'ATCT
TCGCTGTGGG,
GACAAAAAAA
GGAGTI'TGGT
CTI'GGCGGGT
GCTTITTTAGA.
TCCCGCTrAA CTTGGGTTTr
CCCATCCCAA
TTGGTATTGT
AAGTTTGCAT
TTIATTCTAA
GCGCGGGCAT
GTTTTAGCGG
CTCAACTTI'C
ATGGTI'TAAG
AAAAGAGGTG
TATCATCTTr
CCCTATCTGG
GCTTGGTGGC
GCTCTCTATT
TGATITTGGTG
TGGTTACATA
TGGTGAATTG
CACTTATATC
TTATATCGGG
TGCCTTTGGG
AGAAACTCCC
AGAGGTGTTT
AACCGCTTGT
TrTTTCATI'TC AAGrICTATT
GGC'TTTAGC
CGCGCCAAGT
TATGAATT
GATTTCCTT
AAGCTGGTTA
CTITTATATC
AAAACCTTAG
GTATITTTA
TCTGAAATCA
ATAGTGATGG
TTATTAATGG
GGTTTTGGCG
GCTCCTGTT
CCTGGCGCTT
GGTrTTrAA
ATITACATGG
CTTGGAGGAA
GTTTTTCAGC
AAAAATTCCC
ATTTTGATTT
ACTCCGTT'G,
ATTTTCACCG
GCGGCCTTTG
TI'AGTCAATA
TGCCCCATFIT
GCTTATAACA
AACGCAAAAG
CTTATAGTrI'
TCTAATACCC
GATTGTCTTC
CAAGTATCAT
ACACTTATGG
CCCACTGG
TAATCCCAAC
TGGATAGCAT
ITTTGGTGCT
GGGTTITTGT
CCGCTTCCGT
TITIGACAA
TTTTTGGTAT
AAATGAAGCA
TCTTTGGTAT
TTATCCTI1
AAAAAACCTA
GGTTTTTGGC
GGTrrI'TTGG
CTATAATTT
TCATGAGCGA
TAGCCTATGC
CTATAGCAGT
CTTAATTGC
AACACGAAGT
GCTTGGTGGG
TGCCAAACAC
GATCTFI'GCT
GGATAAATI'C
C'IrCGCTA
GGGGCI!ACC
TGTTAGGATI'
CCATGAACAT
AG7TTTGG
GCCTGTTGTT
CATI'TCTGTG
GGACGATGCC
ATCAATCTCC
TGTCCCGAAT
TTCAAATT
TGATAAAATC
CTITrI'ATI'C
ATACTI'TTTA
TGTGTITAGC
TATAACCGCT
GCCTGAAAGT
TTTTATTACA
GTCGCCCACG
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1.200 1260 1320 1380 1383 TGGCGCCAAT TIATCACAAA .0.
0* 0 INFORMATION FOR SEQ ID NO:1423: SEQUENCE CHARACTERISTICS: LENGTH: 1522. base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1. 1521 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1423 AAATCGCTCA AAAAGA.AGTG CCGGAGCTIT TTGCAAGAAT ATGAGGITI'A TI'GGCTTI'AA TGGTAGCTGG GGCAAAATAC AGAGGGGATT TTGAAAAGCG ACCCTCAAAG AGATCCAGCA AAACGGCCGT ATCATTTTAT TCA TTGATGA C rrrGGTG CAGGGAGCAG TAACGCTGGG AGCTTGGATG CGGCGAATAT TI'CTI7GGAT
CCTGAAAAAA
AATCCACACC
ATTAAAACCG
GTnTTAACGC; GTGT1TGAAA
TCTAAGGAAG
cAGGTGCGTI
CATGATA&AT
AAGATCAACC
CTCAAGCTTA
TrGGAAAAAT
AATGCGATCA
TTATTCGTGG
TrGAATTGC
AAGCTCATCG
GCGATTAAAA
AATGTGTATG
AACAAGGCGA
AAGGACACGC
CTTTrAACCC
TI'GGAGGATT
GAGCAAGGCG
TACCAGAGGA
CAATTAAGCG
AAGAGCACAT
ATGGGAGCT
AAGACAAGGC
CGTGTTACTT
ATAATGAAAG
TCTI'GCCGGA
CTAAAAAAGG
AAATCCCTAA
CGCTAAAAAA
AAATCCAGCA
GGCCTAGTGG
ATTrTGAACG
GAAGTCCTAG
AGCACCCGCA
ATTTGTTGTT
GTTFTAAGCA
TAGGGTTTT
CTGAATTGCG
TTGAACGCAT
TGATCTTAAA
GTITTGGTGC
ATATAGTGCT
TTCACAAAGT
GAAATGTTI'G
TrI'CAACAGG
GAITTTAAAG
CGTGTrI'AAG
TAAGGCGAT
CAAAAAAATC
AATGCGTI'A
TAAGATTT
TTGCGGGCT
GGTAGGGAAA
CTTTGACATG
CGGTTATGTG
T1'GTTTGCTG GcAGGTGATG
TGTGATACTG
TAGCACTAAA
ATCCAGAAT
TGTTTCTGTG
ATTCCATAAA
GAGAGAAAT
TAAACAATCG
GGGGCGACCA
CGVITTTICTA
AATATTGCCC
GCATGCGTGG
GAATTATTAG
AGCGTI'GATG
AATAGCGATA
GcCCAAACCG TCTGcAAAAA AcAGAATTGG
AGCGAATACA
GGGTTTGAGC
cTITrAGATG
GATAACGCCA
ATTATGACTT
AACGCCAAGT
GATGCGATCG
GAATTGGACG
GAAGTTGTGA
AAAAAAATCA
CTI'AAAAAAC
CTTTTGAAGA
TAGTGAATGT
CCCTI'TATGA
AITI'GACGAG
ATGAGGTGGG
ACGTGCAAGA
AAAAAGCCCT
AAGCGATCAA
ATAAGCCTGT
CTAAAGAATT
AAGAAGCCCA
AAGGGGGGTT
AGATAGAAAA
CTF1'GAGCGA
CAAATGTGGG
ATGATAGAGC
TGCCGTTTAA
GGT1'AAAAC
AATGCATCGC
TTCAGAGGGA
CAACAAGATC
ATACCCCAGC
TGAAGAGCCT
AGAACACCAC
CTATTACATG
ATCAAGGAAA
AACGCTCGCT
TITTAAGGAAT
CCTTGTCAGC
GGGGAGCT
GGCCI'GAAT
TAGCGTGGCA
ATTGGTGAAT
GGCCCACCCT
TAATFI'AGGC
GAGTAAGGAT
CGTTAAAGAG
CGCGCTCAGT
CCTAGCAATA
GCAA.AGAGC
AATCAACCCC
GTTIGCGCATG
300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1521
C
C*
C
C.
C. C
C.
Ct..
C. CC S C
C
C C
C
CC
CC
CC..
INFORMATION FOR SEQ ID NO:1424: SEQUENCE CHARACTERISTICS: LENGTH: 534 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE- NAE/KEY: misc_feature LOCATION 1 .534 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1424 .00 00 a
GGAATAAAGT
TTAGCGTITCA
GGGGTGGAAG
ACCCTTGCTA
ACCGTCTATC
GCTGATATI-r
GGCTGGCGGA
GAGAGCGATG
GGCTTTTTTA
TGATAAAATT TGTGCGTAAT TGCTTTTAGT GAGTI'ATTGC
TCAAAAGAAT
GAGATGTCTA
GTAACGAAGA
CAGCTCTCGC
TCAATTTIG
AGATGTCAAA
TCAGTGCACG
GAATGAAAAT
TTTTGTGCAA
CACGCGCTT
TCAAAGTTTA
TAACATGTTC
ACCCGTITI'
TTCTGI'rrGC
GTGGTTTTAT
ATGCCCCATT
GAAAACACGC
ACTTACGACC
GGCTTCCCTT
GTCAATCAGC
CCTAATGTGA
AGCTGGATTT
ACTTTATF1'A
TCATFI'TAAC
ATAGCGTGGC
CCAATAATAA
CTAAGGATCA
TTTArFTTAA
AAGTGGAAGT
TTTTTAAA
TATACGCCCT
AGGGCAAAGC
AGCGATCTT
TGTCATTAGC
GGAAGTAAAA
AAAAAGCGTG
GTTTAATTCG
GCAATACTAT
ACCCTTAAAA
GCTACTAGTG
TCAT
120 180 240 300 360 420 480 534 INFOEH4ATION FOR SEQ ID NO:1425: SEQUENCE CHARACTERISTICS: LENGTH: 1914 base pairs TYPE: nucleic acid STRAINDEDNESS: double TOPOLOGY: circular 1000 (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .1914 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1425 0*Oa .0: a. 0 .00:0 1
GCGCGGCTTT
CAAGAATACA
TATI'CTAATA
AAGCTGAAT'
ATCCATTTGA
ATGGATAAAA
TIITAAGCG
GTGGGCTT
ACCAGTCATC
TGCGTCAAAG
TTTGCGAGCC
CCTATTTT
GT1'AAAGAAG
AGCGAATTGA
GAGCCITTGA
TATATCCCTA
CTTTATGTTA
AGGTrI'GTTA
TTACAGCAGA
GAGATTGAAA,
AAAGTGTAA
TI'GAGATITCT
'TAAAAGAAA
GCGTCCCCCC
GAAATI'GATG
GCTAGCCATA
GATCAGTTTA
GTAGAGCTT
ATGATGGCTA
GAATTAAACC
TTIGAGCGCI'
AAAGACGCTA
TATI'GTATAA
CCTTCCAAAC
AAGAGATTT
ATTI'GATGCT
GTTITGATAG
GCGATCTCAT
CTTTGAGTGG
ATITCGGCGTI'
AAGCTI'ATGC
AGGAGCAAGG
GT1'GGGAGAT
TAACTTACAC
AAAAATGCGA
AAGAAAAGGA
GCTATATCCA
GCAAAGCGCC
AACGGGTGTT
AAGGCGTGAT
ATAAGAT1TTT
GGCTGAGCAA
AAGAAGGCTr
ATTCTAAAGA
ATCAAAAAAG
TITTAGAAAA
CGITTGTGAT
GTGAGAGTTT
AAGATITAAT
CTGGTCATCT
ATrGGATGCG
CTAACCATGC
TTATCTGGTT
AAAGTTrTAA
TCTTAAAAAT
TGAAATCAAC
TTTAAGGGAG
AACCGATGAG
CCAAAAAAAA
CGAGCATI'TA
GGATAAGAAA
CATGGTAGCG
ATGGGTGAGC
CACAGAAATC
TGATAGCGTT
CGATACGAAA
TCAGATCAAT
TI'ACAAAGAC
TAATAAAGTG
CTTTGATTTG
TATCACTGAT
TGACAGCGAA
AGCCAATATC
GGATAACAAG
GTATGGGGAT
CAAAGGAGAA.
CATT1'ACTAC
ATACGCTCAA
GCCAGGCGTG
GAAAGAGCTT
CAAAGCGTIT
CACTICAGCG
TCAAATGGGG
GATTTTGCAA
GCTTTATGAT
CGAACGCCTA
TTITATAAAG
CAGCTITTGG
TTGATI'TCTA
AAATTAAAAG
ACCTTAACGA
GGCACGATCG
AAAGATAGCG
AGTAAGAT1'G
GATGGTAAGG
ACCCTCTTI'
GT1'AAAAAGT
TI'TGAGGGCG
CAAGCGAGCG
TTTTACCAAT
GAAGGCTCTI'
TITAGGGTGG
GATGACAAAG
GATFITGCCCT
CGTTCGGCTT
AATI'ACCATA
TTTGAAAACA
TGGAVTTTCTT
CT1TTAGGCG
AAAGGCTATG
AATGAATACG
GGTI'TGGCAG
GAAGAAAATC
GTGGCTTTAA
CAAAGCGTGC
AAACTCTTAA
GGGGCGAAGC
AATAGCGTGC
GAAAAAGTTC
ATTTGATGAT
ACGCGAGCGA
GGCTGAATAC
TTAAAGACAA
CTAAATCAGG
CCTTAATTGG
TCGTTCAAAC
GCAAGTTTGA
TAAAAGAAGA
ATTCTGAGCA
AAGGGGATAA
C'ITTATGGAA
CGTTTGCGCA
TAGAATACAC
ATTATAAAAG
AATT GTTGCC
TGAACGTGAG
CAGTGAAAAA
AATTCTATGA
AAGAAAAACT
TAAAAGAATA
AAAATTTAGA
ATGTTITGTT
ATAAAACGCC
AAATCCATGA
TTAAAGATGA
TAGGCGATGA
CTGAAAGCAA
AATGCGAAGA
TITTTAGAAAA
TATTGAAGGC
AATGTCTAAT
CCACTCTTTG
CGCTI'TGGAT
CACGCCTAGC
TGGTATAGGC
CACGAAGAGT
CCAA'ITTGGC
CAAAAAAG?1'
AATCAGCGAA
AGATTCTCAT
TATCCCTTTC
TAAMAAAGAA
AATGAATAAG
TGATAACAGC
GACGCTTTI'
CGGGGTCAAA
GTCTI'ATTTG
TCGTGAAATC
GATTTAAGC
GCCTTITGGG
TFITAGAAT1'G
CAAAGAAAAT
CTTATThAAA
ATI'GAGCGAT
CTITAGAGAC
TGAGGTAAAA
GATTAAGGGC
ACCAAATGCG
GAAAACTITA
TAAAGAGCAG
AGGGGCTTI'A
GTTG
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1800 1860 1914 0 0 %9o p INFORMATION FOR SEQ ID NO:1426: SEQUENCE CHARACTERISTICS: LENGTH: 1275 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: 0 1001 ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc feature LOCATION 1 .1275 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1426
AAGCAATITG
CTrATAAAAT
AACAAAACAT
CAAGAAGATG
GTCAGCTITG
GAAATCCCCT
ATGCAAGAAA
GCTCCAAAGC
TCAGGCAAGG
AATI'TAAACC
ATGATGGGCT
1-rAAAAGCTT
CTCATITIGGA
TGGGGGGATT
ACGCTAGCCC
AGTTTAGATG
GGCATTGTAG
TTTGGCTCAA
CTCCCTTTAG
CATCCCACTA
ITAGACAAGG
CATGCTI'ATI'
GTAGGCGAGT
TCCATGCCCT
GCTATAAAGA
TCTTAAACGC
G'TTTTGTTAA
CAAGCTCTGA
AAGGCGTGAA
ccACCACTAA
GCGGTGTGGG
AAAAAGTGGG
TGCAAAACGC
TI'GGCGTTTC
GAGGACCCAT
TAGACGTGCT
AAGCCGTGCC
ACGCTAAACG
AAAATATGGG
ATTCCATGAG
AGCCTAAAGT
GCGTGAGTGC
TGGAAAGGGA
CGCAT
TTTI'ACCCAA
ATCCTTTAAA
AAATTCAAAT
GTI'AAAAACG
AAACATCACC
GGAAACGAGT
AGCTITGAAT
AAATCTGOCT
TAAAAGCACC
GCTACTAGAC
TGATGTGATC
TGTGATGAGC
GCTCATGCGA
GGTGGTGGAT
ACTCAGCGCA
GAGTTTGGAC
GAGTTTTGTG
TGGATTATI'A
GCGTCTAGGG
ATTCCTAAAA
AACGCAAATT
ACTATCATTT
ATCATCTACC
TTGCATGACA
GCGATTITAA
TrGGATATrA
AAAAACATCA
ACCAGCGTGA
GCTGATGTGT
ATGGATCCTA
ATGGGGCTTI
GCGATI'GAGC
ATGCCCCCAG
GGAATCACCG
ATGITI'AAGA
TGCGAGCATI
GAGGCTTATA
GGGGATAAGG
TGGTGCAAT1'
TAATTTATAA
TAAGGATTAA
CTAATTTTGA
ACCAATTAGG
GGGAAAATAT
AAACCCCGCC
AGCATGTGGT
ATITTAAGCAT
ATGCCCCTAA
GCGGTAAAA
TGTATGATGA
AGATGCTAAG
GAACAGGCGA
TTACTACGCC
AACTACACAT
GCAAGAAAGA
ACACGCAGAT
GTGAACCGAT
CAJAAGGATF1'
ACATCCAGCC
TCAAAACACG
TGCAAAATI'A
AATGCTCACC
AAAGGATATI'
GCITTI'AATA
CTCCAAAGCG
TAAACCGCAA
CATGATAAGC
CGCTrI'AGCG
TATCCCTAGA
ACTCATI'CCT
GGGGCAGAGT
CGATATTAT'
TGCGCAGCTC
TCAAATCGTG
TCCTATI'GCG
GAGCGAGATI'
TFI'AGCCAAG
TGTGATTTCT
GAGTGCTT
CACACAAACG
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1275 0* TAAAATITI' GAAAAAATGG AAAACTAGCC GATAATAAGG INFORMATION FOR SEQ ID NO: 1427: SEQUENCE CHARACTERISTICS: LENGTH: 1329 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .1329 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1427 CTAGGTI TGCCTFTGCA TGGGTrTTT AGAGTGGGAT CGTITTCGCG TATCGCTTIC ATFI'ACCCTA CAGGGAGTFTA TCTAACCACT CTCCCTAAAG GGA'FIGAAAA CCACAAATIG 'FrAGCTTATG A'ITCCACGAA ATTrTTGATT CCAGCGAACT GGTATTACAT GGGGCGATGG TGGACCAGAG AGCAAAAGGC TCAAAACGCC GATTATCAAT ATAAGGACAT TFI'TGGGAT ITITTGAGCG GGTr1'AATCA AGGGTI'TGAG GTGTGGTTTA GCACCTTTGG AAGGGCTITA
CTCAGCGCTT
AACCAATCGA
ACCGGGGCI'
GGTTTTGGGG
GATGAAGCCA
GAGGGCTATI
AGGCCTTATG
AAACTAGGGC
ATTTTACC
GCCAATGAGC
rTGAGTATCA
TCATCAAT'C
TACAAGTTGA
TGGGGGGCGA
ACCCTAAGGC
TGATGCAACA
TGTTATACAA
GTTACCCTI'C
GGTGGAAAAA
AATACATI'AG
AGTGAGCGCT
CAAAAAAGGG
TI'CTAGTIWG
AATAGGAGCG
AGGGITTCAG
CAGCCAAAAT
TI-I'TATTrA
TAAGGCTTTG
GTTTAAGATA
GGATrTrMAC 120 180 240 300 360 420 480 540 600 1002
GCTCCTGTCA
GAAAATAAAT
CCTGGATTTG
ACGAC'.7TIIT
GCCGCTI'AG
TCTTATCGTT
TGGAATGGCT
GCTTATI'CCA
ATIAAGAATC
CAAAGCTTAG
GTIAATGGCT
TACAACCCTG
TATCGTTIT
ATTACAAGCA
ACATTAGGAT
AAATCACCCA
ACGCATGGTI'
TGGGTAAAAA
TTGGCTGGAG
CACCCATTGA
ATTIITACAA
TTTGGT GCA
GGGTTACTTT
ATCAAATCAC
ATFI'CGCTCA
AAAAATCAAC
CGCGCCTTI'
TGACACAAAA
TCCTCTCTAT
AAGCGCGGCT
CGTGTATAAG
TCCTITTTTAC
CGCTAATI'CC
ATTGTATGGG
TAAATATAAC
GATGCATAAG
AACCATI'CAA
TACGGCATGC
ATTTGG'1TTT
TCTTATI'GGA
AGCGACTATT
TTGTTTGTGT
AATTTTGGGA
GACACGAAAG
ATAACGATTA
AAATTAACCT
CTI'AAAAAAC
GGTTATAAGG
AATAGAAGCT
ACAATTTCAA
ACCCTAAGAA
AATCTCTTT1G
TGTCTAAAGA
TTCAAAGAGT
ACGCGAGCGT
ATGATACCCC
ACGCTTTTAT
AITCCCCAAG
ATATCTATT
TAGGGTTTr
ATTI'GATGAG
CCTCGTI'TAC
TTTTAACGCT
GCGCATCCAA
TI'ATTATAGG
GAATTTCCGC
TCAGTTAGGT
TTATGAAGAC
AGGGAAGAGC
GGCTGATGCG
CATGCTAATG
TACAAGCGGT
CTCTATGAGT
660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1329
V
V
*VV.
V.
V
INFORMATION FOR SEQ ID NO:1428: SEQUENCE CHARACTERISTICS: LENGTH: 414 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .414 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1428
V
TACCCTACAA
CTAATGATAA
GCGACTGGGG
ATGAACGATG
GCGACTAAAA
CATGAATTAA
TTAGAAGTTA
ATACTATTAT
GCGGTGTTIG
GGAAATI'CAT
AACCGGTGGT
AAGTAGAACC
AATACTCGCA
AAATCATCAC
TGAAAGGAT
TGTGGGGGCA
GGGGAAAATG
GATTAAAAAC
CAAATT GGC
ACAGATATIT
GGACAAGGGC
TTGATGTT
AAGGATTTGG
ACGGACTCTA
CTTATTGTCA
GATAAGTTTA
TACCGCCTGG
GAATATI'ACC
AAAAAATGTG
ATITCAAGCT
GTCTITAAG
ATAGGGGAAA
AAAAAGAAAA
ATI'GCAAGCC
ATAAATTTTC
T1'TGAGCCTG
GGATTATCGC
TATCACTTCT
TTCAGTCGAA
ACTCTITGAT
TAACCAATTG
CAAA
INFORMATION FOR SEQ ID, NO:1429: SEQUENCE CHARACTERISTICS: LENGTH: 1173 base pairs TYPE: nucl~eic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: 1003 NAME/KEY: misc-feature LOCATION .1173 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1429
AGGATTGGCA
CCCAAAGAAT
GAATGTGAAA
AAGCATGCAG
CATTTTTGCT
CCCTTTAAAC
GGGGGCGT'G
CTrTCTATrr
CTAGAAAAAC
TGCGAAAAAG
CTCATTTTAA
GATACGCTCG
TGITTTGACC
GTTACACCAG
GAGAGTTTGA
GAATCAAGCA
GAAAATATT'
GATGCGCGAT
AGGATCCATG
TTTITTGGGGG
TGGACGCTT
GCGGTATT'TT
AAAATGGCGT
AAAAAGAACA
TTGCAGGGCA
CCATCATTIAA
GGGcGTTT
TACTCACGAG
TCAAAGAAAA
TCTI'AGGCGA
AAGGCGTI'CA
CTTCAG Tr
CTTCAAAATT
GGAGCGTAGA
AAGAATA'FIT
GTTCGCCTIT
TAAAAACATG
TTITI'AGCGC
CCGTTGATGA
TTTAGAGGG
AGAAATCACC CAAAAACTCA TGAATACATT AAATCGCTT GAAAAACCTT TTTTTATACC TGCAAAAGAA AAGCATGTAA TATI'GATGTC GTGCCTCCTG AGAGGGGTr TTATACGGTC GAGTGCGAGT TI'AAATTIA CGATGAAGAA GGGCCAGGGA GGATI'TGCTG CCTCATATGG TAGCATCAAA ATTGGCCGAA AGGGCATGTG GCTI'ACCCC GCCTCTCATT TCAGGAGTTC AGTCATCACC AACTI'GCATG AATTGCCTT'r AATGCGCGCC GGAAAAGGIT TTGAAAGATT CATCACGGCT TCCCATTCAA CCACACCACC CCCCTTITAA TCATGGTATA GAAGTGGTGG AAGGGTGAGC TI'GAAGGAAT CTTGAGCGAG AAA
TCAGTTACCC
TTCCTGCTI'
GCATITITAA
AAGAAAATGT
GGAACAATTG
GTGGGGCGCA
ACCCTAAAAC
TTITI'GGCAC!
CGATTGTGGC
GAGGCTCTAT
AAAAATGCCA
ATTTAGACAA
CAGGGITAGG
ATCTTTAAA
TGCCTTATAC
AGCTTACTAG
ACACCAAAGG
AGTITTGGCGC
TAGAGCTTTT
TACCATTACG
TAAAACCCTA
CCCCCTCAAA
TAAGCCCTI'G
GCAAAGTGAT
AGACATGAAG
CCCTTT'ITG
TAGGCTTATG
TGAACCCACT
TAATGGCAAA.
AAACCCTATI'
TGGCGATGAG
GGCTAATAAT
AACCACCCAA
TTTAGAATTA
CGTITTTACAA
CGGCACGAGC
CATTAATGAC
GGAAAAAGTG
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1173 INFORMATION FOR SEQ ID NO:1430: Wi SEQUENCE CHARACTERISTICS: LENGTH: 2784 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .2784 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1430
ACAAGCCTTG
GAAGTCAGTC
CATGTAGAAG
GACTA'TTCAA
TI'AT1'AGAAT
GAATATGCCA
AACAATCAAT
CCTAATAAAG
TTAGCAAAAA
ATGGAAGACA
ACAAAATTCA
CCTATCAATG
GATGAAATAA
CACTGCAAAA
AAAAATATCC
ATCACAAAAT
ATAAT1AA
CTTTAGGGGA
ATATTTGCAC
CATTTAGA
ACGTAACCAA
TGGTTAAAAA
AATACAAACC
TI'TATTCTCA
TCTIAAAAAA
CACCAAAAAC
AAAA'FITrAA
AAAAGGATT
ATGAATGCAA
AACAAATATG
CACAGAITTTT
GGAATTATCA
ACAATGCAGT
T.LTIGTGAGT
TTITI'ATAAA
TAATCTGCT
TITTTATCAG
CAATCAMTIT
TITAAAAGAA
GCTAGAGGAA
TGAAATTAAG
ACGGCAATT
TGAGCGAAAC
TAGCGAAGAA
CAAAAAT1'AT
TCTI'GCGTGG
AAAACGCTAA
AACTI'CGTT
GATTIATAA
GATAAATTAA
TTCAAAAAAT
TGTATAAGAG
TTATAATAG
CTTAGTGCAA
TTAGATAAAA
GATAT1AITA
AATGAGI'TG
AAAGAGTCGC
GAGCCGGAGT
ATAGAAAGTC
A'T1'GAGGAT
TCAGCTATCC
CTATITCCCAT
ATC?1ATAGC
AATI'GAGCGA
TAATCAAACA
AAATI'ATAAA
GGAAAGGCAA
GTGAAATTAA
TTITTAAAAC
AAGAAATAGA
AATCAAATAT
TGATCCGAGA
ATAAGATI'AA
CCAATCTAAA
TTTGAAAA
TAACAATGAC
TTCTI'ACAAT
GCTIGTAACT
F1TAAGCGGC
ATACAACGCC
ACAAAAACAA
ACCACAAGAT
TACCGACTTT
CGAAAAATAC
TGAAAAACAT
AATIGAAAAT
TGATCTGCTC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 ATGCCGTTAA TGATGTGTCT 1004
AAAGATATTA
TCAGAAATG
GAGAGTATAA
GAAAxTCAAGG
GAGTTCGCAG
ATAAATAATG
GAGCCAAAAA
AGCCAATTAT
CCTAATAAAA
GATTTAGAAA
GAAATAGATC
AAAATAGAGA
ACAAGITTTC
AAAATAGATT
CCCCAAGATA
AAATATACGG
AATGAGCCAA
TTTGGCTTTC
ATGGACGAGC
AAAGAATACC
GTGGATACGC
A L'1AAGAAT(
AAAATCAAA(
ATcATTTT( CG2'TACAAA(
AAAAACGAT'
CCTATTGr cGATTTAAA.
TGCGATAGG
GCTAAAAAT
GAAGATGCG
TGGGCTACA
AATccATGAT
TGCGATACAG
AAATITrAGA
ATAAATTTGA
AATATTGCCG
GTTTATCTCA
TCACAGATAA
CTGGGCACTG
TTTGGA'FTCC
TCTAT1'rTGA
AAGAATCACT
GTAAGCATGA
TTTTTGCTAA
CTTTAATTAC
*GTTACcAATT
AACATGAAAT
TCATCTTAAG
TI'TATAATGT
CAGCCACTCA
CTCATAAAA2'
ATCATTTAG;
AcTITAACT;
GCTCT'TAGC
STAGAAGGCAI
3 AATACAAGGI r CAAACGATK r TGAcAGACG! A GAGcTAATG,' C ATTCAAAC.
A AGCAAATGG.
A TAGAAAAAC
GTGTCAGTTT
ATACACAAT C TAATGAAAGT
G
AGCAAACAAG G AGAGTGTAAC
C
TCAATTTGAA
TGACCTTGAA
G
GTrTTTCAG
C
TTI'AGAGTTC TAGTCATGAA
I
AAAAAAGATC
TAATAACGAT
AGGAAG~rTT
AAAAGAATT
AAAAATTCGT
AAAACTTGAA
CCAGCAAAGC
GGGATCACAT
TTTGAGCGTG
TCATGTTACT
TGAAATAAGG
TCCCCTAAAT
AGTGGGCCAG
CACGGATTAT
~CAACCCCATr r' GAAAGAAACC k. TGACAGAAAA ,k AGAAATGCAT, P, AATTGAAGAT A ATTGAGCATG A AACAAAAAGA ATTI'GAAAC A, TTTTTGAAC
C
GcATTI'ATT
T
,AAAAATTCAA
'CCTATACAG
C
AAITCGTGC
C
~CCATATCAA
C
:'TTCGTTAT
~aTAAAAGAT
C
~CGTTCAATA
I
LzAAcAATCAA kTACTGCAAC
;CAGAAATT'
kATAAGCTI' GTccGACATA
GTTTATGATT
AccGGC'FTCC
TTTAGTTTTA.
CCAGCCAGAA.
TTTGTTTTAG
ATTGTGGAAA
AATGCAAGCA
CATGTTTTTC
TGTTATTTGA
CCTFITCACT
ATTGAA.AAAC
TGCGTTrA.
GATCCCATCA
TGTrrCAGCG
GCTTTTAAAA
AATTFI"TTAA
OATAGATTI'
AATACAAAGA
GTrcccTAAA ACAAAGCAA GTT1'AACTT
'I
AATCATGAA;
:CAAAGAGAC
TAATAAAAC
.AAAAATAAA
CTCTAAAAA
AGAT1'TTTT rTGAATTTTT rAGAATACAA rAGCGATCGT kCAATAAGCT GcAGAAAATC
AATGGGCGTT
ACCATAATAT
AGGAGTTI'AG
CCACCCATGA
AGGAAACAGA
AAGACTCCGA
ATAACCCCCA
GCGCTTTI'AA
TCTTACCCAT
TTTlGCGAGTT
ACCAACAAGC
ccATCCTACA
CAAACGATAG
CAAGGCTTTr
AATTATTCAA
TAGTCAAT
,TCTTTATGG
,AATATTGGT
LAATGTTTCT
CATCTAAAT
iGAATACAAA
GGTCTI'GCT
LMACTTTAAT
;TlTGATAAA %.TACT1'GCAA rTCAATTcAA rGAGAATGAT
CATGCAAT'A
TCAAGATAGT
TCCTAGAGAG
ccACGATCAC
TAATTTCATG
TATcTATGTC
GAAATTTTTA
ccccTTTTA
AGGCTCTGTA
CGCTTTGGAC
AAAACACCGA
ATTGTATTG
TrCAGGGCTT
AGACAATCAC
AACGAGCGAA
ACTcTCAGAC
AAACAAATAC
GTATGGCGGA
ATGGATTGCA
96bU 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1.620 1680 1740 1800 1860 1920 1980 2040 2100 2160 2220 2280 2340 2400 2460 2520 2580 2640 2700 2760 2784 ACTTGATCAA
AAAC
INFORMATION FOR SEQ ID NO:1431: SEQUENCE
CHARACTERISTICS:
LENGTH: 873 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL.
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION' .873 (xi) SEQUENCE DESCRIPTION: SEQ ID N0:1431
CAAGCATTGG
TTTATTTTAA
ACGACTGAAG
ACTCTAGAGC
GAAGAAATCC
AATGAATCCA
ATCCTI'GGCG
ATTCAAGCTT
GTATCAATAT GTGITCTAAA
AAAATAAGAA
GCT1'GTGCGC TGAAGAAAAT
ATCACCAAAG
AAAACACCCC TAAAGACGCT
CCCATTCTIT
TTAAAGAAGA AAATGAAGTG
GCAAAAAAGA
ATAAGAAAAA ACGCCAGCTI'
TACATGCTCA
TTTATTCCA ACAAATGGCT
AAAAATAAGA
ATATAGGGAT TAACGCTAAT
CCTTATGAGA
CTCCCTTGCT GTATGGTTTA
AGGAGCGGGT
ATCTCATT
AAAACATGAC
TGGAAGAAAA
TTGATGAAAA
AAGGGGAATT
GCGGCTTI
AGTTTGAACT
ATCAAAAGTA
ATGCTTGGT
TGAAACGAAC
ACGCGCCCAA
AAGCCTGCT'
GCATGAAAAG
TATAGGCGTG
TTTAAGCAAT
TTCGCTAAC
120 180 240 300 360 420 480 1005
GGGATITAGCG
AGCGATTCTT
CCTATrGACA
AATGGGATGT
TIGGTGTTAA
CTAAAAATGC
AATATTI'ATT
CCTI'ACGCTTI
TAGCTI'CTTA
AAGAAAAAAG
ATCAAAATrT
ATTAGGGGT
CTCCCTTAAA
ATATTAGTTA
TTATGGGGAA
TCAAACCGCA
GTTTGCGTTA
AAAAGAGATI'
GAGCATGACG
AGAAACTCG
CAACTATTTA
TATTTAGGGG
AGCFI'GAATA
GGGATATG
AGAGGGTATT
CTCAACCTCA
CAAACCTr
TTG
GGGCGATGAA
TI'GATCTGr1'
GAGGCGTTGG
CACAGCCTAA
AACACCGCFr
TATATTATT'
AGGGTTITAAA
GATGGATAAG
AGTGGGGTGG
CGCCT1'TGGG
TGAATI'AGCC
TAAAAGCACT
INFORMATION FOR SEQ ID NO:1432: SEQUENCE CHARACTERISTICS: LENGTH: 678 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION 678 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1432 S. S S. *5S* S S *5
S
*5*S AGATTTFFTA GAAAGCATAG TCTITTAACT ACCACAATCG GAT1TTTTAT GCGTITI'AGG ?I'AGGGCTTT TAAAACCCAG AACGCTTTTTI TACGCCAAAA TTAAACGCCT TACAAAACAT GCTCAAAAAG AAGCCAAAGC AAATTCCCTA ATGAATTGAG ATCCACAGGC CAGAACTCAT CGTAAGAAT' TACAGGATCT ATGGTAACGC ATGATGAAAA GCCCTI'AAAC AAGAGCAG
GGTTATAAGC
CGCTATFTI
GGAGAGCGGG
TCTGGGGAGC
AATAGGCTAT
GACTrTI'TGC
CTI'AGCGTTA
TGGGGGGCAA
'FITATTAGAT
CATCAAAGAA,
CGAGGCGCAA
ATGAAAGAAA
AAGGATTITA
AGCGGTAAAA.
GF1'AAAATCT
ATCGCTCAGG
CTTAATTTAC
AAAATGGGGT
GCCCAAAGAG
GAGCCTTA
ATACACCAAA.
AAGTTAGCCA
TCGTTACAAT
ATTTAAGCAT
GCACGCTTT
TTAATGAGAC
GCAATTCCTT
AAGGCATAAA
TAGACGAGAG
TGGGCATTAT
GCGCTTTAGA
ATTCTrGCGC
CAAAAACCCT
AGAGAATGTG
TCAAGAAGGG
AGGCTTGAT
T
CCTCAAAC
ATI'CCCTCAT
CAAACAAGCC
CCTTATGGAT
TAGGGGGATT
TAGTTTGAAT
TACTFrCAT'
AGAAATCAAA
INFORMATION FOR SEQ ID NO:1433: SEQUENCE CHARACTERISTICS: LENGTH: 1782 base pairs TYPE: nucleic acid STRANDEDNESS; double TOPOLOGY: -circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature 1006 LOCATION .1782 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1433
ATGGCTGATT
TTTGATAAAA
AAAAGCTATT
GTCcAAATGA
GACGCTITGA
TTAAGAGACG
ccITTAATCA
AGCGGGGCTA
AATTGCATCA
TGcGAGGATA
AVFIGAAAATA
AACTIGCGTr
GCCCCTTTCA
GGTGGGAACA
TCAGCGTTTG
GCCATI'ATCA
GCTTGTTCTA
AAAATCGCTC
AAAAACGCTC
GAAGCGCGAT
AGCCACCATT
cAAAAAGAcT
GAATIGCTCA
ATAGATGGAG
TTGTAGAAG
GGGGGTGCTA
AAACGCTTGC
cATAGATCCA
TATTGTCCAG
ACCGCCAAT'
1"ITCTGTCCG
TGGTCAAACA
TTTTGGAAAA
ATAAAACT1'A
CACGAAAAAT
AGGATATTIT
AGGATAAAAA
AAATCACTAA
AAGACAGGCT
TTGAAGAAGC
CTTGCATGGA
AcAAGGCGGT
AAAAAATCCA
ATcATTACCA
ATGAAACGCT
TTAGCATTCC
AAGAGATTFIT
CGCTCTTCAA
CAAACAGCCA
CTTATCGGCG
CCAGAAGGGC
GGAGGGCGCA
TGATCGCTAT
AAGACX1"TAT
AGTGGGTGCA
cTAAAcTTAA TTrrGAAAAAC
ACTCTACATC
TAATAATGAA
GATCGCT1FI'
TTCTFI'GATC
CCCTTATATT
CTTAAAACAG
GGACAGCTTG
GGCATGCATG
AGAAGAATAT
CATCAAAGAG
CTTAATTAT
TTTAGCCAAA
GTTAGTGAAA
CTCTCTCAAC
ATCGCATTTG
TAAAGAATTG
TAAAAAGGGT
TAGCCAAGAA
TI'TAGAGTGC
ATGCGTGGGG
CTACCATCTA
TTTAGACTTT
ATTAAACATC
TTCTAAAGAA
CCATACGAT7
AAAATTGCGC
AAACATGAAA
*ATTGTTGGAM
*CGCCGTrrr? cTTTCTAGTA
GGTAAGGCGA
ATCACGCCCA
TTAGAAACCA
AAGCAGCTCA
TAcATGGATT
CCTGGCGTTA
TATGAAF1'GC
TI'TTATCAAA
T1TAIAAATCG cTTGAATTGA
AGGGATAGGA
CTCTACGATT
ATGTTCATGC
GGGTTTGACA
CCTTTGATGC
CAAGAGTTTA
GATAAGCTCG
AAAACCTCTA
GTGCCTTATA
GGAATGGTCG
AAAGGCTCTA
GCTAAAGAGC
GCTTTAGAAA
AAAAGGGATT
AGTCATACTI
GATGAAAGCC
CAAATCGCTC
TATrI'TGGGA
AAAAAACGAJA
GTAGTGGGGT
AAAATTTAAA
ATCCTCGCAC
TITTTAGTGGA
AGCCTAAATA
'FTTCTATTGA
AATATTTTGG
TCCCTTI'GGT
TAGAGCGTTG
CTAAAGAATG
AAATGGAGCG
TTGCAAAAAT
TGGATATTTT
GTGGGGGTAA
CTGATGAAGC
CTGAACAAAT
TCTCTCACCA
CTrI'AATAGA
ATGAAGATCG
GGGTAGAAAT
TGTATGAAAA
ACGAATATGA
CACCGCCTAA
TTTTAAAAAG
CTAAGGCTTA
TI'AAATTGCT
ACCGGTATGC
TITTAAAAGA
GTTTTGAAGC
6 AA
GTATCAATAT
AAAGCGCATC
AAGCTTACGC
AAACGAGCAA
CAACATCTT
TTTCCCTATC
CCCTTTI'ACG
TCAAAAGAAA
TAAAGCCCCA
TTTAGAAATG
CCTITCTAGT
CCAAAAAATC
TGCTITTrTAT
AATCATTTCT
GATGAAACAA
CTI'ATIGAGC
ATATI'CTAAA
AATCGCTATG
GATCTTAGAA
CTTTGACACA
CAATGCATT
TCAAATGAGC
'rrTGTGGGTG
CAGCGGGAGT
TCGTTCTAAA
CCCTAGCGAC
GATAAACTrC
AAAGGGCATA
GATAGAAAAA.
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1782 GGAGAAGccA GcGTGAAAAA GCGAGCGATC AGGAAAAAAA INFORMATION FOR SEQ ID NO:1434: SEQUENCE CHARACTERISTICS: LENGTH: 1272 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM:- Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .1272 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1434
AGGAAAAACA
ACGGTCGCTA
ATTAAAA'rrA
ATCAGTGATG
ATGGGTGGGG
TTCGTTACAG
TGAAAAAAAG
AAATCI'ACA
AAAAAGCGGT
ATTTAGAAAG
TGGAAGCGCC
ccAATAAAGC
ATTGAATATA.
AGAAAATCAA
GGTGCGAGA.C
CGTGATAGAA
TrATCTrTTA
CATGTI!AGCG
GGGCTTGTGG
GAAATCATrA
GTGAAAAAAC
GATAAAGGGA
GCTAAAAAAA
TACCACCGCT
GTTTAGGGTG
AAGACAGAGC
ACAAGGGCTA
T1'GATATI'GT
CTTTAGCCAA
ATGAATTAGA
CGTGGGGAGC
CGGCGTGGAA
TGCTI'GAA
CGTGGAGCT'
ACAAAAAGCC
ACAAATCGCT
120 180 240 300 360
E
1007
AAAAACACCC
TTAAAAGACG
AGCAATTACA
GACGCGCAC
GCGGCGCACA
GAAATCTTGA
'TTGGTIATA
AGGGTGCATC
AACGCTATCA
GGAGGAGAC
AGCTCTCTAA
ATCCAATGCG
ATCAGCGCGA
CCGCAATCCA
CTGAACGCCC
CGTTTGGAAA
ccATAGGCT'
GCTI'GAGCGC
TTITAAGCCA
ATTTAGGCTA
AATTATTGAT
FIGAAGGCAT
GCATCAAACT
cAAGcATGAT
GCGTCATAGG
cTAcCGCAAG
TGCTGGGCTT
CTTACTATGC
TTITAGCCCA
ACAAGGCTAA
T1'AAAGAGCT
AT
TGAAGCGAGC
TAATCACATC
GATGTTAAA
TGCGGAATTG
T=rAGCGTCT
TGAAAAGATA
TTTAGGCATC
TAAAAATGAA
GGATAAGGTG
CGCGGTCATT
TGAAACCCCT
GCCTGTIA
AAATGATATT
AATcTTATTT 'rGAAAATTI'A
GTGTGTGGGG
CTI'TCTTITTA
AATCAAGCGA
AAcCCTGAAT
TTAGCGTATG
GAGCCAGATG
GCTAAAAAAC
TGCATGCTCT
GGCGAGACTI'
AGCGATATI'A
CAAAAACTCC
GTGAGCGATG
TCGCTCAACA
TCCACGCACA
CAAAGCGTGT
GTATCCCCAT
AAGGGArrr
GCTITAAGGA
ITGACAITAA
GCATI'GATGC
ACATGGAATT
ACCAGGATI'G
CTAAAGTGGA
TGTATTATGG
TAGAAATCGC
CCCTAAAACC
AAAAAGGGGT
ATGTCTTGCA
CCACCAACGA
TGGATACCCC
TATCAAGGCT
AAACGGCACG
CGCITTGAA.A
GGGCATTGAT
GAAATTAGAA
TGCAAAAGAG
CATTGAATTA
TGGGGTGATG
GGCTGGGGCT
AAGGAAAAAA
CAAAGAAGAA
TI'TTTCTCAA
AAAAGAAATC
AAAATCTATG
TAAAATGATC
420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1272 0 INFORMATION FOR SEQ ID NO:1435: SEQUENCE CHARACTERISTICS: LENGTH: 978 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geriomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAMAE/KEY: misc_feature LOCATION .978 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1435
V.
V V
V
AGTCGCFITTA
AT1'ATTGGAG
AAAAACGCCG
ATrGAAAA'rr
CAGGAGCAAT
AAAAAAGGTT
GTGATCATCG
TGGGGTAAAG
GTAGCGGTGC
TGCAAAAAAG
GAGCATGCTA
AAGGGCGATG
AGAGAATTAG
TTGAAGCAAG
GATTCCA
GCCCCCAAGC
AA.AGAGCAAT
GTGGTCCTGC
TITTATFI'GA
ATCCGGGCGT
GCTITCGCTI'
CTCATTI'GT
CTACCGGTGG
GCGTI'AGCAC
TTrGGTGGAGG
TCTATCTCAT
AAAACAATAG
CTI'CTGGCGT
TCGTGCCGGG
AAGATAACTC
TGAAGACGAA
AAGTGGTFI'G
TGAACAAGCT
AGGTFI'GAGT
AAAAGGAATG
TAAGGAAGTG
TGGTTTAAAG
TATITI'GGCA
TAGCCCTAAA
TI'GTGCAACA
CGATACCCCC
CCACAGAAGA
TAAGATIGAG
GTCTTCTFI!A
GCTTI'ATT
CATGCTATGC
TGTTCAGGGC
TGCGGCAAGC
TTTAGGCTAG
GCGGGGCTT
CCTGGGGGGC
GTGAGCGGAT
CATGAGATGA
GAAGATGGCA
CGCACAGGTA
TGCGATGGCT
GTAGAAGAGG
GATGGTTI'A
TTITTAACCC
AGCATTAAAA
TTTGTGGGTT
GAATGCGATG
TT'GTTrTGCGG
GATGGTGCTA
TGGCCATGAT
ATGCCACTAG
AAATCACTGG
TGGA'FF1CAT
CCGCCATI'CA
AGACTTTTGA
TCAAGGGCGA
TCT1'TTACAA6
CGATTTATCT
GGTGTGCGCC
CTTATGTGGT
ACACAGCCAC
ATGATGTGAA
AATACGGCTC
CAGGAGATAT
CGGCAGCCTT
AGAFI'GCGCG
AGGCGGTGTI'
CAGTAGTGAG
GCAACCATGG
AAGGGTTTCT
AGCTAAGAGC
GTCAGAATAT
MAATAAGGAA
AGCCAATATC
TATCACTI'TA
GGAAGAAATC
TAACGAAAAA
TAACGCCGTG
TAITGTCGTG
TCGCATTI
AAGCGTGAT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 978
TCTTA
1 ITTAG AACACCAT INFORMATION FOR SEQ ID NO:1436: SEQUENCE CHARACTERISTICS: LENGTH: 837 base pairs TYPE.: nucleic acid 1008 sTRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .837 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1436 St C S Sn.
C S
S.
SC 55 p
S
p *5 5 0~5* I p Sr C *5t~ *5PS tSp.
AAAT1'ATGGG AAATTrG7T
CACCAAGCGC
CTAGTTAAAA
GCAACCAGTC
TrTATGAGCT
ATAGAGCTCA
AAAGAGGGCT
CATI'ATTGT
CAAGAGCGTG
ATCACGCCCA
GATACGATAA
GTGATCGCTG
AAAATCGCTC
AGTTTAGCTI'
TGGTTITTTAG
AAATTTTTGA
AGcATTTACA
TCATCAGTGA
TGGGGGAGCT
ATGAAGCGAT
TGGATTTT
ATGATGCCAG
TGGGGATCAT
AGATI'GCCAA
TGGACGCTAC
ATGATGAGCA
TAATGAGAGA
GCGTGT1TT
AGACACCACA
TGCGATTTAT
CCCTTATTTC
GGTF1'CTAAG
TGGGTGCTAT
CTGTATITI'A
AGAAAAACAC
CGTGAAAAGT
TAAAGCTTAT
AGTTTTTTTG
TTTTATCCAT
AATCTCTACG
ACTCCATITTT
ATCATTTCT
ACTTTACTCA
TCCAAGACTI'
ATCACGCAAA
TTTTATTACG
GCGAGCCATIT
GAAGACGATA
ATCCAAGAGT
GAGCCTTTAA
AGCCATGGGG
AAACACAGCC
GGCGTGAAAA
ATAGCGCGAA
AAATTTGA
TAAATCAAAA
ATAATATCAA
TTGAAGGCGG
ATATCAAAGA
CTTTAAAATA
ATI'CGTTGTG
TAACCTTGAA
TAGGCTATGC
ACCATGAAAA
TGGGGACGCA
GAAAATGGGT
ATCTGGTGFI'
AAGAAGAACC
AATGGTGGCA
AGTGTGCGAT
CGCCACCCAC
GTTGCACCCC
CATGGGGT
CCATGCGAAA
GCAAAAATGC
AGAGGATTIT
GCG'ITTGATG
CCAAGAGATA
AGGCTATGTG
TGTTCCTGTG
ACAACCTr
CTATAGCCCT
GTTTGTA
120 180 240 300 360 420 480 540 600 660 720 780 837 INFORMATION FOR SEQ ID NO:1437: SEQUENCE CHARACTERISTICS: LENGTH: 708 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .708 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1437
GGGGATTITA
AATATACAAG
GCTGGAAAAT
GCACAAAACA
GTTGTCTCTA
TATCAATITTT
ACCTACGAAC
CATCACCCAC
TAATFI'CTAA
AITTTTCATT
CAACGCTTAT
ATAATATTCC
ACCTATTCAA
TrCACAAAAA
ACCTAAGCGA
AATTAGTTAT
CATCAGCATA CACCCAAAAA CCATG TTI'AA TAAAAATCAT ACTAGTACAG CCATTATTGG CAACACTATT CTAGGCATTA GATCAGACTA ATACCACCAC AATGTTATAC CACAACGCAA CTACCCACCT GGATTAAACG CAAACGACCT CTGCACTCTA GATIGTITG AAAAAAATCT CGGACAAAAA CAGCGCTTAA AAATTGACT TATGGATGAA CCAGAAACCA GTTTAGAGCA
AAACGCTITA
CACAAATGGT
TAWT1AAA
GCAATTGGGA
TT'rTAAATTC
TTTAAATAAA
AGCTCTTAGC
AAACGCTCTT
120 180 240 300 360 420 480 1009 ATAAGACTAT C.AAATCTCAT AAGCT1'GCGC AACACCCAAC ACTCATGATC CTATIGTCTI' AGATAGTTGC GAATGGGTAT ATI'GCTCAAT ACAAACCFIT AAATTCTATA TTAAAATCTG AAAGAAAAAC CAACCACAAA AGACTTIAFI'A GCGTTACTAA AACTI'ACAAG TATCATCGCC TGCTCCTTAA GAATGGCA.AC TAGCTAAAAC TIT1'AAC TTr
AGGATATT
INFORMATION FOR SEQ ID NO:1438: SEQUENCE CHARACTERISTICS: LENGTH: 339 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .339 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1438
S
ATTTATTCTC ATCTCGCTCC GATCTTI'TA TAACTI'GTCA GGGGTTFTT'G TATCTAACGG A =TATCAG GGAGTITAAC GGCTATGTITT TI'GGGAGCTr ~ATCGCTAAAA TCAGTTA.A
CATTATGCAC
TGTGTTAAGG
CTTGGCTCGT
CCCACACCAA
TTTAATCCAA
ATTAATCACT
TATCAATrAA
ATCAAAATGC
TTTGGCTATG
AGCTrCCAAC
TTTAAGCC
TTGAGTTTT
CAAGTTTCAA
GCGTGTIGT
TGGTrAAT
TGGGTATI'GC
CGTTAATGTC
TATAATACAA
TTGCTITTTA
CCCCCTACTC
GGTGCTAATG
ATAGAAAGC
120 180 240 300 339 e a.
a INFORMATION FOR SEQ ID NO:1439: SEQUENCE CHARACTERISTICS: LENGTH: 240 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Jielicobacter pylori (ix) FEATURE: NAME/KE:Y: misc_feature LOCATION 1...240 (xi) SEQUENCE DESCRIPTION: SEQ ID N0:1439 AGTATGGGCG GATTCACAAG CATATGGCAT TGGGTCATrG ITTI'ATAGT TrATrGGG CTAAAAAGAT CCCAGAATG GCTAAAGGTT TAGGCAGTGG ?TCAAAAAAG CCGTGAXAGA CGATGAAGAA GAGGCTAAAA ACGAGCTAAA GCTCAAGCAA CACAAACCAA AGTGCATGAA ACTAGCGAAA TTAAAAGCAA
GATTGTGT'G
GA'ITAAGAAT
AACCCTAGAC
ACAAGAAAGT
1010 INFORMATION FOR SEQ ID NO:1440: SEQUENCE CHARACTERISTICS: LENGTH: 801 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/ KEY misc-feature LOCATION I1.. .801 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1440 *4 *4*4 4.
4
AGAAAAACCA
TI'ATCTATTT
ACTTITATTT
ACTGAAATT
GCGATCTTI'G
TACATGCTAT
ATCGT1'GTAA ATCACTATrC 'ITG.L7ITGCr
TTAGGATIT
TTIAGAATACC
AATCAACTI'C
ACATFT1rrCA
ACACCAAAAG
ACCACAAAAG
TAAAACTI'GA
ATCCTATTT
TTTAC'TTA
GTCTCACACA
CACCAGCAAC
TCCTATATGC
TTAATTTTAA
TTTGCTTGGC
GTAATATCAT
TACCTAATAT
TAATCAAAGC
TTIATTGGTGG
AACGCATGCG
ACT1'ATI'AGC
AATCAAATCT
AATGCTCCTA
TAACATTATA-
AGCTATAACA
T
ITTCAAACAA
TFITATCTTT
AGCGCTTATIT
AATITrrGTA
CAATCTCTAT
TGGTCAATI'A
TITTCAAGGG
CATTATITTTA
T
GTTACTAAAG
TATCTCACCA
TrACTAATrT
GGTCTAATGG
AGCTCTAGAT
ATAACTCTAG
ATTGT1'CTCT
TTGGGGTA
GCTAGAATT
GCGCTAATGT
TTTATCAAAA
ATI'GATACTA
TTTTTACTAA
GATAITTAAT
ATACAAGCGC
TTGTTI7C
GACTI'CTTAT
CGCATAATAT
CATTAATCGC
C'11'F1TATGC TTAGCAT'rrr T1'CAAAACGA
CTI'GTAATGT
CATCTATTIT
TACTGGTITT
GCGCTAATCG
GGGTGCATT
GCTATF1TTGG
AAAAAATACC
TATI'TCTAGC
ATTCTTAT'C
TCAAGACTA
GCTCAATATC
TTCAAGCGCA
ACAAAGCATC
TITI'GTTCCT
TI'ACTACCTI'
AGCAACTTCA
CATGTI'ACTA
*44* 4e .4.
INFORMATION FOR SEQ ID NO:1441: Mi SEQUENCE CHARACTERISTICS: LENGTH: 816 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/FEY: misc-feature LOCATION .816 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1442.
AGAAAACAAG AAATGAAAAA ACTrCTI'A CTC~AGAGC ATAAGATCGT AAAAAT1'GGC TTAATTAI'G TGArI'GTIT AGTGG11 TTTCTTTTTT ATGAACAAGA AATCAAAGAA 1011
AAAGCTIA
GAAGGCATI'A
AGCGTI'AATG
cAxAAGTTAC TI1ITCAACT
CGTATTAGCA
ATAAAATCCA
GGTI'CTTr
TCAAGGGGAA
TCGCTATIT
ATAGGATrAA
TCGCTTGAGT
ATG2TTTCTCA
AGAATAAAAT
AGAATATAGA
CAAATITGCC
ACAATACCGC
GCCAAAAAGA
AAGAAAAACG
CCTI'GCTFI'C
TAGGATTGGA
CCTTATIATC
TcTTTTGTIT
TTTCATCATT
AGGTAAATTC_
AGATACTATC
AAAAACACAA
TAAGGACTTI'
TAACGAAGAT
AACGCAACCT
AGAACI'GAA
CAGTITCTI'CT
TTIGTGAGAAG
TTCATTGTI'
TTCTAAGTTI'
GTCAAGGCTA
CCCACTTCAT
AATCAAGTGA
AAAGATFI'AG
AATAAAACAC
GAAAAAAACC
CCCATI'TCTA
AAAGAATGGG
TCTTTCTT
CTCAAATCCT
TGCCATCCAC
TCTAGAGAGC
GGATCA
CTrAT'rTGTT
AGCCAAACGA
ATGATTAA
TrATTAAACC
GCCTGGTGAT
TAAAAAATAG
CAAAACCTAG
CTTITGAAGT
ITTTAAAAGC
TCTCTTr
TAGTGAATGC
TCAAGCTTAC
TGAAACTAAA
TGCGCTAGTG
ACAAAGTCCA
17TI'AGCGTCT
CGTTTCTCAC
TGT1'TCTTr
TTCTITTIA
'FITITCAAGT
TI'GCTCTCTA
GTCTAACAAT
180 240 300 360 420 480 540 600 660 720 780 816 a. a a a a INFORMATION FOR SEQ ID NO:1442: SEQUENCE CHARACTERISTICS: LENGTH: 1014 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOT HET ICAL: NO (iv) ANlTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1014 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1442
AAAATCTTCA
T1'GCCTAAGA
GTI'AAGGCTA
GAGCAACAAA
AAAAAGCGTG
CTFTITCAAG
GCTCTAGCCC
CCTI'ATI'TAG
AAGAGCATCC
AGAGAAAATA
CAAAGCGCAT
TACACTAATA
ACCCAAGCCA
AAGCGTI'ATA
GTTCCCCTAA
TIAAAAGATT
CATGTCGAGA
AAAAGGCTTr TrT1AGAAGA
AAGCAATAAA
AGACACAAAG
ATATGTIACA
CAGAGCGTAA
TrATAGAAGC TAACC r~C
GTGCTAATCA
t
TTCAAGTAT
TTGAAGTGTG
TAAATCTAAC
AAGGCATAAA
AAGATTAAAA
CGAAGAAGAG
AGAAAAAACA.
AAGCACTATG
AATI'GGCGAT
CATTATTATI'
AAACGCTACA
AGCGCTT'G
AAAAGAGCAA
GGATFTT1'
ACGAAAAAT'
ATGGAAAAAG
GAAAAATATG
CTTGAAGAAC
CTCAATGGAT
TTA'TTTGATG
TGGATTTTTA
GTATGCTI'AT
CAAAATITTTG
AGACAATTGG
AACGAAATAG
GAAAAACTGG
AGCATI'ATCA
CTTTCATA
TF1'GAACCTA
ACAGGTI'ATG
AAAGATGATG
CAGTATAAAG
TTTGCGTGAG
GCGATGATTG
AAGTCAAAGC
~TTAAAAAA
AAGTCAAAGA
GCAGTGCGGT
TGCCGTTAAA
CCATAGTCCA
TAGCGTCTTA
CCCACGAAAC
TTTCTTATGA
ATATCGCTT'
AAGAAAAGT'
TI'GAAAT1'1GA
ATGTAACTGA
GTGTGAAATC
ATGTTAAGGA
CGCATGGGGG
GGAAAAACAT
TAAAGCCAAA
AG'FrGGTTrA
AGCTGATGTG
GTTCTTITr
AGAAAAAGTG
AAGAGCAGAC
TGTTAATAAT
CAT1TAGGT'G
GCATAGCAT'
AATCAGTAAA
AGAAAGCGAA
TACAAAATCT
AATTGCGAT'
TAGGATTATC
GCAA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1014 ATAT1'GAAAT ATCCGCACAA GAATAATIAT GACCTI'GAA ACCCTACAGG CTFITATTGT' 'TAGATGAGAA AAATAAAGTC AAAAAGACCC TCATATGAGC INFORMATION FOR SEQ ID NO:1443: SEQUENCE CHARACTERISTICS: LENGTH: 930 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) 1012 (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATUJRE: NAME/KEY: misc-feature LOCATION .930 (xi) SEQ UEN CE DESCRIPTION: SEQ ID NO:1443
GTTGTGGTAA
AGTIATCTTG
AAAACGCTGT
GCTATTGTTG
AAACTCTTAT
TTAATCCTTA
ATTATCACTG
TCAAGCATTG
ATTGAAATCT
CGCTTGCATG
ATCAATAGCA
AGCGATATTG
GATAAAAMCA
ACCATTAGGG
TAAGGTTAGT
TCTCTGTTAG
TAGTGGATT
TCTTTTGTAT
CCAAAAAGGA
TCATI'ACTAC
TrTTAGGAAC
CTGGAGGGAT
CTGGCCTAGA
ACGGGCGCTI'
ATAACACTGC
AACTGGTGCA
TGCCCACTTT
TTTGGGCAAA.
CCTAAACATG
CGATI'TTGTG
TFI'CCCGCAG
AGGTTTrI'AT
TGAGATTTTG
AATCATCGCG
GGTGGGGAT'
AATCCTTATT
GGGCAAAGTA
GGCGGTIT1G
GTGTCGGCGC
TAAGACTATA
CATTGGAATC
GATTGAAGAC
GGACGCTAAT
CTCT1'CTAAG
CTAACATGTC
ATTTGCAAGG
GCAAAGCATI'
TTTTCGTTT
GCGAATITTG
CTCAGCACGC
GCGGTGGCGT
ATTITACACC
GAAGCGCTI'A
CCTAATAGAA
ATTGAATGGG
AAAGATGT'A
ACGGATTTTG
GGGATCTTTA
CGTATTGAAA
AAATTAGCTA
AAAGAITTTAT
TTGGGATAAT
TCTI'ACGGAA
TCGCGCAGGT
TAGGCGTCCA
TGGCTTTAAA
CTTTCAAAAA
ATTTTTAA
GTGTCGCTAA
TCTGTGGGGT
TTGACGGGAT
GACAAAGTTC
ATGTGAGGAG
TCCCTTTCAA
TATAAGGATA
GGATGAAATT
CTTAATCAAG
CAAAACCATG
TACTITITATC
AACCACCTCT
AGA 'ATCTI'
AGGAGACATC
TACTI'CTrI'A
TTCTAATATT
AGGGTATGGG
GGAAAAAATT
GCTGAACT'C
CGAACTCATT
CAAGCTAGAT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 930
S.
S
QS**
GAACGCATCA AAAACGCCCT ATTCTATCA ACAAACAAGA
S
S
INFORMATION FOR SEQ ID 140:1444: SEQUENCE CHARACTERISTICS: LENGTH: 477 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .477 (xi) SEQUENCE DESCRIPTION: SEQ ID 140:1444
AGCAAAAGAA
CATCCTATAA
ACACTMGCA
AAGAGTTTGA
'FTAATAGAAT
ATGAGAGCCA
ATTGATTTAA
GAAAAATCCT
CACAACAAAC CTITITICTA TITCATTGATG TGTr1'GCCTA TATCGCTAAC GCGCTCGCTC TGGCGITCA AAAAATATCT CAAGTCAAAG TAGGCAACCT rrrCTCAAGTG ATTATCTACC GTGGCGTCCC ATrAAGCGAT AGTGAAATCA GACAAGTGCT AGTAAAAAAT ATCGTTACAA AAAAGATTTG CAAGAACTAC TTTATAT1CT CAATGATCIT AAAAAAGCAA ACCAAGAAAC
AAACTAAAGA
AAGCTAGAAA
AATTAGGCAT
CCACAAAAGA
AT1TC'ITACA
ACGCTTCAGC
TGATAGCAAT
4 rrATAAGGAA
CTACATITATG
GATCAACGGA
TGATAAAGCA
TACTGATGAA
CAACACGGAC
TTTTATTGAA
GCTGGTAATA
GAGTATT
1013 INFORMATION FOR SEQ ID NO:1445: SEQUENCE CHARACTERISTICS: LENGTH: 774 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .774 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1445 C S
C
C S S.
C
*5 C
CTCCTTAAAA
ATGGATTTTA
TTGGTTrrAC!
AACCCGCAAC
GTIGAAGAGT
CAAATCAATA
ST'AAAAAC
GAGATAAAAG
ACTAAAAGAT
GAAATTGAAA
ATCCAATI'GA
GTTAAAGAAT
GGATTGGTAA
ATAITGATGA.
AAAAATGCCC
TI'ATTGAAAT
CGAATTTATT
CAGACAAGGC
AAGCAAGCAT
GAGTCTATAA
AAAG'FTCTCG
ACGATCTGAT
TTCTAACCCA
CCCACCATAA
ACGACCATCT
GAGAAATA7AT
GAAAAAGCT
TAATITTGAA
CCACTCTAAA
TAGCATCTI'A
CAATAAAATA
GATTTCTAGA
GGATAATAGT
TGTITATGA.A
TGATAGAAAT
CACAAACAGC
TGAAACGCAT
TAAAGATATI'
CCCCAGTATI'
TCCGTAAGTA
AAAAAATGTG
GGACTACACA
GATAAGGGCG
CAAGAGCCAC
GATCCTATTG
AAAGAAGATG
GCGAATAAAG,
ATGATAGAA
F1'AAAAGAAT
AAGAAAGCCT
TACCAAGAAG
TCTAGCGCTG
AGGTAAATGA
CGTTTCTTTG
TGCAAAAAAA
ATGTrGCAAC
TCCCTT"ATGT
AATGGGCAAA
TCAAFITCT'
AAGGGTTTGA
ATAGAGAAFI
TGAAAGAGCA
TAGAAAATGG
TAGAAAGAAC
AGTATTTCAC
AAAXAGGCAC
TITCTCAAAT
GAAACCCAAG
AAACAATCCT
CGTGAAAACG
GTATITAAGC
TGCCAATGGT
AAGGCGCATC
TFFrATAAAA AGGG?1'AGAA
CAATGAAATC
AAAAGATGGT
CCT1' too INFORMATION FOR SEQ ID NO:1446: Wi SEQUENCE CHARACTERISTICS: LENGTH: 274 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1. .274 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1446 Asp Ala Arg Ser Phe Phe Leu Arg Leu Val. Ala Met Ala Leu Cys Leu 10 Ile Leu Ile Asn Ser Arg Gly Val. Ala Met Gly Tyr Ala Sen Lys Leu 25 Ala Leu Lys Ile Cys Leu Val Gly Leu Cys Leu Phe Ser 40 Asp GJlu His Leu Glu Gin Lys Gly Asn Tyr Ile Tyr Lys Thn Leu Gly Gly Glu Glu 1014 55 Ala Tyr Asn Asn Lys Glu Tyr Glu Arg Ala Ala Ser Phe Tyr Lys Ser 70 75 Ala Ile Lys Asn Gly Glu Ser Leu Ala Tyr Ile Leu Leu Gly Ile Met 90 Tyr Glu Asn Gly Arg Gly Val Pro Lys Asp Tyr Lys Lys Ala Val Glu 100 105 110 Tyr Phe Gln Lys Ala Val Asp Asn Asp Ile Pro Arg Gly Tyr Asn Asn 115 120 125 Leu Gly Val Met Tyr Lys Glu Gly Lys Gly Val Pro Lys Asp Glu Lys 130 135 140 Lys Ala Val Glu Tyr Phe Arg Ile Ala Thr Glu Lys Gly Tyr Thr Asn 145 150 155 160 Ala Tyr Ile Asn Leu Gly Ile Met Tyr Met Glu Gly Arg Gly Val Pro 165 170 175 Ser Asn Tyr Ala Lys Ala Thr Glu Cys Phe Arg Lys Ala Met His Lys 180 185 190 Gly Asn Val Glu Ala Tyr Ile Leu Leu Gly Asp Ile Tyr Tyr Ser Gly 195 200 205 Asn Asp Gin Leu Gly Ile Glu Pro Asp Lys Asp Lys Ala Val Val Tyr 210 215 220 Tyr Lys Met Ala Ala Asp Val Ser Ser Ser Arg Ala Tyr Glu Gly Leu 225 230 235 240 Ser Glu Pro Tyr Arg Tyr Gly Leu Gly Val Glu Lys Asp Lys Lys Lys 245 250 255 Ala Glu Glu Tyr Met Gin Lys Ala Cys Asp Phe Asp Ile Asp Lys Asn L 260 265 270 Cys Lys INFORMATION FOR SEQ ID NO:1447: SEQUENCE CHARACTERISTICS: LENGTH: 149 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...149 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1447 Thr Met Lys Asn Thr Ser Ser Ser Thr Thr Leu Thr Met Asn Asp Thr 1 5 10 Ile Ala Ala Ile Ala Thr Pro Leu Gly Lys Gly Ala Ile Ser Ile Ile 25 Lys Ile Ser Gly His Asn Ala Leu Asn Ile Leu Lys Gin Leu Thr Gin 40 Lys Gin Asp Phe Thr Pro Arg Tyr Ala Tyr Val Cys Asp Ile Phe Ser 55 Asp Gly Val Leu Leu Asp Lys Ala Leu Val Ile Tyr Phe Lys Ala Pro 70 75 Tyr Ser Phe Thr Gly Glu Asp Val Cys Glu Ile Gin Cys His Gly Ser 90 Pro Leu Leu Ala Gin Asn Ile Leu Gin Ala Cys Leu Asn Leu Gly Ala 100 105 110 Arg Lys Glu 145 1015 Leu Ala Lys Ala Giy Glu Phe Ser Lys Lys Ala Phe Leu Asn His 115 120 125 Met Asp Leu Ser Giu Ile Giu Ala Ser Val Gin Leu Ile Leu Cys 130 135 140 Asp Glu Ser Val INFORMATION FOR SEQ ID NO:1448: SEQUENCE CHARACTERISTICS: LENGTH: 268 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyiori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .268 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1448 Asn Leu Ile Tyr Arg Ser Ser Gin Arg Ser Ala Ala
S
S
S.
$55.
S
S. 9 5.
S..5
S
1 Arg Leu Lys Leu Val Asp Pro Gly Gin 145 Leu Thr Arg Arg Ala 225 Asn Leu Ile Lys Glu Ala Val His His 130 Ala Ile Glu Asp Met 210 Ala Leu Asn Asp 35 Arg Pro Giu Ala Ala 115 Phe Arg Asn Val Asn 195 Gly Cys Val Lys Glu Arg Asp Ile Thr 100 Ile Arg Leu Glu Pro 180 Ala Arg Ala Ser Giu Met Asp Ser Thr Leu Asp Ala Trp Gly 165 Gly Val1 Gly Leu Glu 245 Pro Ile Ala Asn 70 Glu Ser Giu Phe Val1 150 Cys Val1 Ala Leu 230 Ly's Met Ala Met 55 Ala Pro Giu Val1 Gly 135 Val Tyr Ser Phe Lys 215 Gly Leu Ile Ser 40 Gin Gin Ile Val Phe 120 Giu Pro Ala Leu Ser 200 Val Arg G lu G iu 25 Gly Ala Leu Leu 105 Ile Ile Pro Ile Cys 185 Thr Ile Ser Asn 265 10 Tyr Trp Ala Ala 90 Ala Giy Val Ser Phe 170 Met Ser Leu Pro Gin 250 Phe Leu Giu Va).
Ala 75 Cy~i Asp Ser Lys Lys 155 Gly Gly Thr Gly Thr 235 Lys Arg Lys Asp Asp Val Pro Thr Cys Asn 140 Met Ala Asn Arg Ser 220 Lys Asp Leu Ala Ser Lys Lys Ile Asn Thr Met 125 Ala Asp Ala Gin Asn 205 Ala G iu Lys Cys Asn Giu Pro.
G iu Asp Gly 110 Thr Pro Giu Gly Ala 190 Phe Glu Glu Ile Val Ile Thr Val Ile Pro Lys Asn Pro Gin Ala 175 Arg Asp Leu Tyr 255 Val Lys Leu Leu Asp Asp Arg Ile Ser Giu 160 Arg Val Asn Gly Met 240 Arg Tyr Met Asn Phe Asn Leu Met GiU 260 INFORMATION FOR SEQ ID NO:1449: 1016 SEQUENCE CHARACTERISTICS: LENGTH: 430 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...430 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1449 C. o Oee* f e Lys 1 Phe Phe Cys Ser 65 Thr Ser Ile Asn Gin 145 Tyr Thr Pro Glu Glu 225 Ile Thr Lys Phe Leu 305 Leu Pro Met Phe Ser Ser 50 Phe Tyr Gin Leu Thr 130 Val Lys Lys Thr Leu 210 Gin Glu Glu Gin Lys 290 Ile Ser Lys
I
Leu Ile 20 Pro Leu Leu Glu Val Ser Tyr Lys Thr Pro 100 Leu Pro 115 Leu Leu Phe Asp Glu Ile Glu Gly 180 Tyr Val 195 Ser Leu Leu Gly Tyr Asp Ser Leu 260 Ala Thr 275 Asn Ser Leu Ser Thr Gin Asp Arg 340 5 Val Pro Cys Gin Asp Ala Lys Ala Ser Glu 165 Val Pro Ser Met Asp 245 Asn Ser Thr Gin Ile 325 Lys Cys 1 Pro Leu Tyr 70 Ile Lys Lys Tyr Asp 150 Lys Glu Thr Glu Leu 230 Asp Val Phe Leu Ile 310 Asn Asn 4et Ala Lys 55 Asp Leu Glu Val Leu 135 Glu Glu Asn Val Arg 215 Ala Gly Glu Ser Ile 295 Gly Phe Leu Ile His 40 Asp Asp Asn Ser Val 120 Asn Glu Lys Leu Asn 200 Leu Thr Leu Val Lys 280 Leu Leu Asn Phe Asn 25 G1n Leu Asn Lys Tyr 105 Gly Thr Ser Phe Leu 185 Lys Tyr Phe Ile Lys 265 Asn Asn Leu Pro Ile 345 10 Leu Gin Met Asn Leu 90 Glu Arg Arg Pro Pro 170 Gin Thr Phe Ile Gly 250 His Phe SThr SGlu Ser 330 SVal His Ile Leu Gin 75 Asn Pro Tyr Asn Glu 155 Phe Asn Gin Gly Ser 235 Glu Gin Arg Pro Tyr 315 Leu Asn Ala Ile Gin Asp Pro Lys Ala Asn 140 Lys Ile Thr Leu Gly 220 Pro Arg Glu Lys Thr 300 Lys Leu Ala Lys Lys Asn Glu Val Ile Ile 125 Asp Leu Ile Thr Glu 205 Ile Asn Leu Asn His 285 Thr Pro Leu Leu Ser Thr Gin Ser Phe Glu 110 Leu Phe Glu Ala Ile 190 Asn Asp Ser Arg Ile 270 Asp Lys Leu Leu Gin 350 Tyr Glu Ile Leu Ile Leu Val Asn Glu Leu 175 Asn His Tyr Pro Gin 255 Ser Ala Ser Lys Thr 335 Asn Pro Tyr Ala Leu Arg Lys Arg Phe Phe Lys Arg Leu Leu Leu Leu Pro Phe Lys Ala Ala Met Ile Thr 160 Leu Thr Thr Lys Val 240 Ile Tyr Phe Gly lie 320 Gin Ser Asp Glu Thr Leu Ile Glu Tyr Ala Ser Leu Leu Glu Ser Asp Leu Arg 355 360 365 His Asn 385 Asp Ser 1017 Asp Trp Val Asn Tyr Ser Ser Ala Ile Gly Leu Glu Met Phe Leu 370 375 380 Thr Leu Asp Pro His Phe Lys Lys Ser Phe Gin Glu Ser Leu Glu 390 395 400 Asn Gin Val Arg Tyr His Asn Gin Ile Tyr Gin Ala Leu Gly Tyr 405 410 415 Phe Glu Pro Ile Lys Asn Glu Ser Glu Thr Lys Lys Glu 420 425 430 INFORMATION FOR SEQ ID NO:1450: SEQUENCE
CHARACTERISTICS:
LENGTH: 486 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...486 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1450 Tyr Leu Asp Asn Tyr Leu Asn Thr Phe Ile Phe Asn Gly Phe .0 a Leu Arg 1 Lys Ile Asp Tyr Tyr Ala S 9.
y Leu I Gin Ser 65 Gly Val Ile Thr Tyr 145 Asp Asn Gly Phe Ser 225 Tyr Lys Ser 50 Val Ile Asp Gly Leu 130 Leu Ser Ser Arc Glu 21( Sea Al Phe Pro Ser Phe Ser Val 115 Ile Ile SLeu Tyr STyr 195 SLeu r Phe a Pro G1n Leu Lys Pro Asn 100 Gly Asp Gly Ile Leu 180 Leu Asp Gly Ile Lys Leu Val Thr 85 Leu Gly Gin Arg Glu 165 Phe Ser Tyr SArg SVal 245 Leu I Ala I Gly 70 Ala Leu Ile Ala Trp 150 Ser Tyr Asn SLys Ala 230 SThr er Gly Lys L 25 >ro Leu Leu I 40 Phe Asp Tyr I 5 ?he Asn His Thr Phe Val Pro Lys Asn 105 Leu Gly Ala 120 Thr His Gin 135 Trp Gly Phe Asp Ala His Ser Tyr Gly 185 Met Asp Phe 200 Ile Asn Ser 215 Leu Ala Phe Glu Asp Gly .0 jeu Lys Arg Phe Val Ser Lys Phe Ser Ser Lys Leu 75' rhr Ala Thr 90 Ile Glu Lys Leu Ala Tyr Ile Tyr Gly 140 Leu Gly Asn 155 Thr Arg Asn 170 Asp Lys Phe Met Ser Ser Lys Ile Ala 220 Gly Gin Trp 235 Arg Lys Glu 250 Ile Gly 30 Ile Leu 45 Gly Val Asn Ser Ile Lys His Ser 110 Asp Ser 125 Ser Glu Ala Pro Tyr Val His Leu 190 Tyr Thr 205 Leu Lys Ile Arg Val Tyr Val Gin Ala Tyr Ala Lys Leu Leu Thr Leu Trp Leu 175 Lys Glr Trp As! As! 25' Va Val Asn Glu Glu Gin Lys Lys Phe Lys 160 Tyr Leu Gly Phe 3 Trp 240 p Gly 1 Met Ile His Ala Ala 260 Pro Phe Ala Tyr Gin Leu Tyr Phe Ser Ser Lys His 265 270 Phe Ser Pro Lys Ile Tyr Gly Ala Pro Gly Val Lys 1018 275 280 285 Ilie His Ile Asp Ser Asn Pro Lys Phe Lys Gly Leu Gly Leu Arg Ala 290 295 300 Gin Thr Thr Ile Asn Val Ile Phe Pro Val Tyr Ala Lys Asp Leu Tyr 305 310 315 320 Asp Vai Tyr Trp Arg Asn Ser Lys Ile Gly Giu Trp Gly Ala Ser Leu 325 330 335 Leu Ile His Gin Arg Phe Asp Tyr Asn Glu Phe Asn Phe Gly Phe Gly 340 345 350 Tyr Tyr Gin Asn Phe Gly Asn Ala Asn Ala Arg Ile Gly Trp Tyr Gly 355 360 365 Asn Pro Ile Pro Phe Asn Tyr Arg Asn Asn Ser Val Tyr Giy Gly Val 370 375 380 Phe Ser Asn Aia Ile Thr Ala Asp Ala Val Ser Gly Tyr Val Phe Gly 385 390 395 400 Giy Gly Val Tyr Arg Gly Phe Leu Trp Gly Ile Leu Gly Arg Tyr Thr 405 410 415 Tyr Ala Thr Arg Ala Ser Giu Arg Ser Ile Asn Leu Asn Leu Gly Tyr 420 425 430 Lys Trp Gly Ser Phe Ala Arg Val Asp Val Asn Leu Giu Tyr Tyr Val 435 440 445 Val Ser Met His Asn Gly Tyr Arg Leu Asp Tyr Leu Thr Gly Pro Phe .9.450 455 460 *Asn Lys Ala Phe Lys Ala Asp Ala Gln Asp Arg Ser Asn Leu Met Val 465 470 475 480 Ser Met Lys Phe Phe Phe 485 INFORMATION FOR SEQ ID NO:1451: 99:. SEQUENCE CHARACTERISTICS: LENGTH: 254 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: 99 ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .254 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1451 Val Tyr Ala Gly Leu Ala Ile Ala Ile Gly Met Leu Ile Asp Sen Ser 1 5 10 Val Val Val Val Giu Asn-Ala Phe Glu Lys Leu Ser Ala Asn Thr Lys 25 *Thr Thr Lys Leu His Ala Ile Tyr Arg Sen Cys Lys Glu Ile Ala Val 40 Ser Val Val Ser Gly Val Val Ile Ile Ile Val Phe Phe Val Pro Ile so 55 Leu Thr Leu Gin Gly Leu Glu Gly Lys Met Phe Arg Pro Leu Ala Gin 70 75 Ser Ile Val Tyr Ala Leu Leu Gly Thr Leu Val Leu Ser Ilie Thr Ile 90 Ile Pro Val Val Ser Ser Leu Val Leu Lys Ala Thr Pro His Ser Giu 100 10s 110 Thr Phe Leu Thr Arg Phe Leu Asn Ang Ile Tyr Ala Pro Leu Leu Giu 115 120 125 Phe Leu 145 Pro Ser Ala Gly Thr 225 Asp 1019 Leu Gly 140 Val Gly 155 Ser Val Met Leu Ser Ile Gly Leu 220 Trp, Ser 235 Phe Lys a a.
a a a a a. a a a. a a a a.
a INFORMATION FOR SEQ ID NO:i452: SEQUENCE CHARACTERISTICS: LENGTH: 157 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .157 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1452 Trp, Leu Phe Leu Thr Cys Tyr Gly Ser Val Ile
I
Arg Val Asn Gly Lys Lys Asn Ala Gin 145 Leu Ser
LYS
Thr Gly Lys 100 Ala Phe Asp Met Ser Ser Glu Leu Lys Glu Gly Gly Arg Ile Ala Phe Gly Lys Thr Lys Glu Giy Ser Asp Gly Val Pro Tyr 135 Gly Leu 150 Lys Phe Glu Leu Leu Lys Lys Val Lys 140 Arg INFORMATION FOR SEQ ID NO:1453: SEQUENCE CHARACTERISTICS: LENGTH: 225 amino acids TYPE: amino acid 1020 TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .225 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1453 ease 000.
4 Pro Pro Arg His Asn Gin Asn Sen Ala Ala 145 Leu Gin His Leu His 225
LYS
Leu Asn Phe so Asp Asp Leu Leu Asn 130 Lys Leu Lys Giu Sen 210 Trp Leu Ile Glu Leu Ser Asp 115 Tyr Gly Pro Gin Arg 195 Phe Ile Ser Lys Ang Sen Asp 100 Tyr Leu Glu dly Val 180 Asn Leu Ala His Asp Pro Asp Lys Ala Gly His Thn 165 Ile Thn Ala Leu Val1 Pro Tyr 70 Ile Glu Lys Ser Gly 150 Ala Sen Leu Val1 Aia Val 55 Pro Val1 Vai Asp His 135 Leu Met Tyr G ly Asp 215 Arg Ala 25 Gly Val 40 Lys Thn Met Pro Ala Tyr Phe- Ala 105 Lys Ala 120 Ala Pro Asn Val Pro Ang Leu Giu 185 Ile Lys 200 Trp Lys 10 Thr Leu Ala Ala Leu 90 Gin Phe Asp Phe Val1 170 Lys Ile Arg Leu As n Lys Phe 75 Thr Ser Ser Leu Ile Gly Ala Met Lys Leu Ala Leu Ser Sen Cys Asp Ser 140 Asn Leu Gly Ile Val1 220 Ile Ala Pro Leu Ala Met Ala Leu Asn Pro Lys G ly Ser Ser Gin Ile Gin Pro 125 Met Asp Asn Asp Phe 205 Trp Thr Tnp Phe His Phe Leu Ang 110 Lys Met Pro Giu Arg 190 Phe Sen Phe is dly Leu Lys Ser Pro Cys Asp Ile Gin
LYS
175 Lys Ala Glu Gin His Ala Phe Asp Lys His Leu Ang Lys 160 Ala Lys Val Val1 INFORMATION FOR SEQ ID NO:1454: SEQUENCE CHARACTERISTICS: LENGTH: 381 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc_feature LOCATION .381 1021 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1454 Thr Trp Arg Tyr Gin Leu Gly Ser Leu 1 Lys Glu Lys Pro Ser Phe Glu Tyr Leu 145 Pro Leu Glu Lys Glu 225 Arg Glu Phe Phe Phe 305 Phe Ile Leu Leu Ser Asn Thr Thr Glu Tyr His Ser 130 Ile Ser Gly Asn Ala 210 Ile Lys Ser Phe Ile 290 Leu Ala Ser Glu Glu 370 Val Phe Asn Ala Phe Gin Ala 115 Lys Asn Leu Leu Ala 195 Leu Leu Ser Pro Ile 275 Asp Lys SThr Asp SLys 355 Lys Glu Lys I Leu I Asn Arg Gly 100 Thr Asp Thr Ser Ile 180 Met Glu Gin Val Lys 260 Met Glu Ala Thr Asn 340 Glu Ala 5 Ile Leu Leu 3ln Lys Asn Ile Ile Thr Pro 165 His Phe Asn Cys Tyr 245 Arg Val Ile Leu His 325 Glu Ser Leu Glu Ile Glu Val 70 Ile Thr Pro Asn Ile 150 Met Ser Ile Leu Phe 230 Ile Leu Ser Glu Phe 310 Asn Thr Ala Tyr Asn Asn Ala 55 Ser Lys Ala Leu Leu 135 Thr Thr Asn Pro Gin 215 Asn Gin Leu Ile Ser 295 Lys Lys Gly Ser Arg 375 Tyr Lys 25 Phe Phe 40 Leu Tyr Leu Pro Leu Asp Asn Pro 105 Thr Ile 120 Asn Ser Lys Pro Met Thr Leu Asp 185 Ile Glu 200 Leu Ala Pro Asn Ile Lys Asn Leu 265 Leu Ile 280 Gly Leu Leu Ala Glu Phe Val Phe 345 Gly Phe 360 Gly Met Lys 10 Asn Thr Thr Pro Ala 90 Ile Gln Asp Gin Tyr 170 Lys Leu Ser Ile Asp 250 Phe Asp His Gin Leu 330 Lys Ile Phe Gly Asn Glu 75 Asp Ser Tyr Asp Leu 155 Glu Ile Ser Lys Leu 235 Glu Gly Asn His Lys 315 Leu Asp Arg Glu Gln Thr His Asn Ile Pro Ala 140 Gin Phe Ala Ile Glu 220 Asn Asn Trp Arg Thr 300 Leu Asn Ile His Gly Lys Ile Gin Met Ile His Asn Gly Ala Leu Arg Thr 125 His Phe Glu Gin Val 205 Lys Ala Thr Gly Val 285 Lys Gin Ala Ala Ser 365 Leu Asp Leu Val Lys Thr 110 Gin Met Ser Arg Thr 190 Asn Glu Asn Pro Phe 270 Lys Met Ile Ile Leu 350 Tyr Lys Ala Cys Asn Thr Glu Thr Thr Tyr Gin 175 Tyr Ser Leu Thr Leu 255 Ile Tyr Gin Gin Asn 335 Phe Ser Met Gly Asp Ile Phe Phe Ser Asn Asn 160 Asn Lys Leu Ile Ile 240 Glu Lys Leu Glu Ile 320 Thr Glu Met Glu Val Arg Gly 380 INFORMATION FOR SEQ ID NO:1455: SEQUENCE CHARACTERISTICS: LENGTH: 284 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori 1022 (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...284 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1455 Thr His Cvs Leu Phe Leu Gly Gly Ser Ile Lys Ile Leu Leu Ile Leu 1 Lys Thr Gly Lys Val Leu Ile 9 9* 9' 9 9 99 9 Leu Gin Pro Gly Val Glu 145 Phe Ile Leu Ser Asp 225 Gly Glu Ala Asn Lys Leu Tyr Phe 130 Thr Gin Lys Tyr Tyr 210 Glu Lys Ile Pro Thr Ser Gly 115 Ser Ala Val Val Ile 195 Ser Arg Glu Thr 5 Ile Asp Asp Asp Gin Ser Glu Asp Gly Ile Ala Phe 100 Leu Asn Asn Glu Pro Asn Ile Ser 165 Val Arg 180 Gly Gly Ala Glu Gln Val Glu Tyr 245 Glu Ile 260 Leu Phe Ser Phe 70 Asp Lys Ala Gly Gly 150 Pro Tyr Lys Ser Phe 230 Tyr Leu Asn Ile Asn 55 Tyr Leu Arg Thr Lys 135 Asp Lys Gly Thr Tyr 215 Thr Ala Val His Pro 40 Val Asn Ser Glu Phe 120 Leu Ile Ser Thr Gly 200 Asn Ile Ser Arg Lys 280 10 Gly Tyr Tyr 25 Ser Lys Lys Gly Met Ile Gly Leu Leu 75 Leu Glu Ala 90 Val Leu Lys 105 Leu Gin Leu Thr Thr Pro Tyr Ile Pro 155 Ala Arg Lys 170 Gly Lys Asn 185 Thr Ala Arg Ser Ser Phe Gly Val Val 235 Lys Ile Ala 250 Tyr Asn Tyr 265 Asn Arg Leu Gin Ala Lys Gly Thr Gly Leu Tyr 140 Ser Met Ala Val Phe 220 Ile Ala Leu Lys Leu Val Ile Tyr Gly Ser Arg 125 Leu Pro Lys Gin Ala 205 Gly Leu Pro Ser Gly Val Ser Gly Lys Va 1 110 Ala Val Lys Glu Phe 190 Lys Phe Gly Ile Pro 270 Lys Glu Lys Phe Ile Ser Tyr Gin Pro Thr 175 Glu Asn Ala Ser Phe 255 Ser Tyr Asp Ser Ser Pro Tyr Ala Arg Thr 160 Leu Gly Gly Glu His 240 Lys Ile Ile Gin 275 Asn Ala Leu Glu INFORMATION FOR SEQ ID NO:1456: SEQUENCE CHARACTERISTICS: LENGTH: 139 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...139 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1456 1023 Asp Lys Lys Ile Leu Leu Ile Ile Gin Gly Lys Phe Met Glu Phe His 1 5 10 Gin Val Tyr Asp Pro Leu Gly His Ile Trp Leu Ser Ala Leu Val Ala 25 Leu Ser Pro Ile Ala Leu Phe Phe Ile Ser Leu Ile Val Phe Lys Leu 40 Lys Gly Tyr Ser Ala Gly Phe Leu Ser Leu Ala Leu Ser Ile Leu Ile 55 Ala Leu Phe Val Tyr Lys Met Pro Val Gin Met Val Ser Ala Ser Phe 70 75 Phe Tyr Gly Phe Leu Tyr Gly Leu Trp Pro Ile Ala Trp Ile Val Ile 90 Ala Ala Ile Phe Leu Tyr Asn Leu Ser Val Lys Ser Gly Tyr Phe Glu 100 105 110 Ile Leu Lys Glu Ser Val Gin Ser Ile Thr Leu Asp His Arg Ile Leu 115 120 125 Val Ile Leu Ile Gly Phe Cys Leu Ala His Phe 130 135 INFORMATION FOR SEQ ID NO:1457: SEQUENCE CHARACTERISTICS: LENGTH: 97 amino acids TYPE: amino acid TOPOLOGY: linear **gt (ii) MOLECULE TYPE: protein S: (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori S: (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...97 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1457 Pro Lys Pro Lys Gly Val Cys Pro Lys Asn Leu Met Ser Lys Arg Ala S1 5 10 0 Ile Arg Phe Pro Asn Lys Leu Phe Ser Tyr Pro Lys Pro Lys Ile Lys 25 Ala Thr Asn Thr Ser His Thr Val Leu Phe Ala Tyr Pro Leu Lys Pro 40 His Glu Met Ala Leu Leu Ala Leu Ala Thr Ser Leu Leu Ala Pro Ile 55 Phe Asn Ala Ile His Ser Thr Asn Ala Leu Asn Ala Ile Lys Pro Asp 70 75 Gly Thr Gly Ser Lys Ile Asn Pro Ile Ile Met Pro Met Lys Ile Gin 90 Lys INFORMATION FOR SEQ ID NO:1458: SEQUENCE CHARACTERISTICS: LENGTH: 532 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein 1024 (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 532 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i458 A. A 4.
Arg a Phe Ser Asp Gin Ly Thr Val Pro Lys 145 Leu Gin Gin Lys Ile 225 Phe Ile Lys The Ala 305 Leu Arg Asp Thr Asn 385 Lys Asn Phe Ser Asp Ile Asn Leu Asn Asn 130 Ser dly Trp Thr Thn 210 Val Leu Sen Ala Ser 290 Ser Gly Val ile STyr 370 Tyr SThr Asp Phe Lys Gly Val Arg Lys Met Ala Leu Arg Val Cys Ile Asn Tyr Lys Lys Pro 115 Ile Met Glu His Gin 195 Thr Lys Ala Sen Ile 275 Tyr Ala Trp Arg Sen 355 Thr Ile Val Phe Gin Val Thr Lys Ala 100 Phe Ala Arg Val Ala 180 Ala Ile Sen Ala Lys 260 Asn Leu Gly Phe Ile 340 Met Asn Phe Trp 5 Leu Lys Trp Glu Ser Leu Lys Asn Leu Leu 165 Leu Lys Gly Gin Leu 245 Tyr Phe Glu Leu Ile 325 Ala Leu Asn Thr Asp 405 Phe Gin I Leu Lys 70 Lys Glu Asp Pro Lys 150 Lys Asp Arg Ile Val 230 Leu Ile Val Asn Ala 310 Ile Lys His Arg Thn 390 Gly Leu Met Lys 55 Glu Asp Ser Leu Ile 135 His Leu Lys Leu Phe 215 Lys Sen Glu Asn Val 295 Ile Leu Gly Ile Arg 375 Met Val Gin Ala 40 Lys Ser Leu Gln Ile 120 Ala* Glu Leu Sen Glu 200 Gin Asn Val Asn Val 280 Thr Ala Ile Thn Thr 360 Ala Phe Asp Ala 25 Leu Phe Val Leu Gin 105 Glu Ile Asn Asp Ala 185 Leu Lys Gin Val Asn 265 Sen Tyr Met Gly Asp 345 Ile Gly Ala Phe 10 Glu Val Glu Arg Lys 90 Lys Arg Ile Leu Gin 170 Lys Gin Asp Leu Phe 250 Glu Val Leu Lys Gly 330 Ile Leu Arg Asn Cys 410 Asp Asp Asn Gin 75 Ile Met Pro Asp Lys 155 Lys Leu Gly Sen Phe 235 Ala Arg Ile Val Asp 315 Ser Phe Glu Ile Tyr 395 Val Lys Lys Tyr Glu Ser Phe Asn Gly 140 Asn His Ser Ala Asp 220 Lys Trp Val Val Thn 300 Leu Val Ile Asp Ile 380 Sen Thr Ser Lys Lys Leu Thr Glu Ile 125 Ile Asn Gin Asp Gin 205 Glu Leu Ile Tyr Leu 285 Vai Phe His Gly Va1 365 Phe His Phe Gin Leu Ile Arg Leu Ser 110 Pro Ser Gin Leu Glu 190 Asn Ala Val Leu Thr 270 Ile Leu Met Vai Asp 350 Thr Val Phe Asp Leu Glu Ala Tyr Arg Glu Tyr Asn Phe Thr Leu 175 Ile Ile Ile Tyr Lys 255 Val Phe Gly Ser Gly 335 Val Phe Pro Gly Ser 415 Leu Leu Lys Asn Leu His Gly Ile Ile Ser 160 Asn Tyr Leu Ser Val 240 Ile Asn Leu Phe Leu 320 Asp Leu Thn Asn Met 400 Asp The Lys Lys Ala Sen Lys Ile Ala Leu Asn Ile Ala Thr Glu Leu Ser 420 425 430 1025 Lys Giu Tyr Thr Asp Ile Thr Tyr Lys Gin Leu Asn Lys Met Arg asp 435 440 445 .Arg Tyr Ser Leu Arg Ser Leu Ser Val Lys Pro Arg Cys Phe Leu Met 450 455 460 Pro Giu Asn Asn Gly Ile Lys Ile Ser Vai Trp Tyr Gin Thr Asn Ser 465 470 475 480 Tyr Ala Thr Met Ser Leu Arg Ser Lys Ile Val Ala Giu Ile Val Giu 485 490 495 Ala Phe Leu Lys Giu Giu Asn Ile His Ile Aia Tyr Thr Thr Ser Lys 500 505 510 Leu Leu Lys Val Asp Aia Asp Aia Leu Giy Asp Gly Phe Giy Asn Lys 515 520 525 Arg Glu Gin Lys 530 INFORMATION FOR SEQ ID NO:1459: SEQUENCE CHARACTERISTICS: LENGTH: 347 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL. YES (vi) ORIGINAL SOURCE: ORGANISM: Heiicobacter pylori
FEATURE:
NAME/KEY misc-feature LOCATION .347 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1459 Arg Ser Giu Arg Met Gin Giu Ile Leu Ile Pro Leu Lys Giu Lys Ser 1 5 10 Tyr Lys Val Phe Leu Gly Glu Leu Pro Glu Ile Lys Leu Lys Gin Lys 25 Ala Leu Ile Ile Ser Asp Sen Ile Val Ala Giy Leu His Leu Pro Tyr 40 Leu Leu Giu Arg Leu Asn Ala Leu Glu Val Arg Val Cys Val Ile Giu so. 55 Ser Gly Giu Lys Tyr Lys Asn Phe His Ser Leu Giu Arg Ile Leu Asn 70 75 Asn Ala Phe Giu Met Gin Leu Asn Ang His Sen Leu Met Ile Ala Leu 90 Gly Gly Gly Val Ile Sen Asp Met Val Giy Phe Aia Sen Ser Ile Tyr 100 105 110 Phe Arg Gly Ile Asp Phe Ile Asn Ile Pro Thr Thr Leu Leu Ala Gin 115 120 125 Val Asp Ala Sen Val Gly-Gly Lys Thr Gly Ile Asn Thr Pro Tyr Gly 130 135 140 Lys Asn Leu Ile Giy Sen Phe His Gin Pro Lys Aia Val Tyr Met Asp 145 150 155 160 Leu Ala Phe Leu Lys Thr Leu Glu Lys Arg Glu Phe Gin Ala Gly Val 165 170 175 Ala Glu Ile Ile Lys Met Ala Val Cys Phe Asp Lys Asn Leu Val Glu 180 185 190 Arg Leu Giu Thr Lys Asp Leu Lys Asp Cys Leu Glu Giu Val Ile Phe 195 200 205 Gin Ser Val Asn Ile Lys Ala Gin Val Val Val Gin Asp Giu Lys Glu 210 215 220 Ang Asn Ile Arg Ala Gly Leu Asn Tyr Gly His Thr Phe Gly Met Leu 1026 225 230 235 240 Ile Giu Asn Giu Thr Asn Tyr Glu Arg Phe Leu His Gly Giu Ala Ile 245 250 255 Ala Ile Gly Met Arg Met Ala Asn Asp Leu Ala Leu Ser Leu Gly Met 260 265 270 Leu Thir Lau Lys Giu T1yr Giu Arg Ile Giu Asn Leu Leu Lys Lys Phe 275 280 285 Asp Leu Ile Phe Asn Tyr Gin Ile Thr Asp Ile Gin Lys Phe Tyr Glu .290 295 300 Arg Leu Phe Leu Asp Lys Lys Ser Giu Asn Gin Thr Leu Lys Phe Ile 305; 310 315 320 Leu Pro Lys Gly Vai Gly Ala Phe Glu Ile Ala Ser His Ile Pro Lys 325 330 335 Glu Thr Ile Leu Lys Val Leu Giu Lys Trp His 340 345 INFORMATION FOR SEQ ID NO:1460: SEQUENCE CHARACTERISTICS: LENGTH: 196 amino acids TYPE: amino acid TOPOLOGY: linear MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION 196 K (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i460 Lys Ser Lys Ser Met Lys Leu Ang Arg Gly Lys Ile Met Pro Phe Ser a 5 10 *Lys Phe Leu Giu Asn Leu Thr Ala Pro Phe Lyi Arg Ile Lys Asn Arg 25 Ser Leu Val Leu Ala Leu Gly Phe Leu Ile Leu Thr Phe Cys Leu Leu 35Ph 40 LuPeLeu Ile Leu Ser Asp Val Ser Arg Leu Ile Ser Ser Lys Asp 55 The Leu Tyr Val Ile Gin Sen His Pro Lys Gin Thr Leu Ile Glu Asp 70 75 Giu Asn Tyr Phe Tyr Ala Asn Lys Gly Leu Tyr Lys Thr Asn Lys Glu 90 Ala Phe Leu Arg Val Tyr Lys Ile Pro Glu Sen Met Pro Ile Giu Lys 100 105 110 Arg Giu. Ser Lau Ser Lys Val Ser Lys Ile Phe Leu Ala Lau Leu Phe 115 120 125 The Ile Ser Ser Met Leu Phe Gly Ile Phe Trp Arg Leu Pro Lys Arg 130 135 140 Leu. Asp Thr Lys Met Ser Leu. Giu Sen Ala His Lys Asn Glu Leu Giu 145 150 155 160 Asn Ala Phe Gin Arg Tyr Asp Ala Leu Gly Val Arg Phe Giu Asp Ile 165 170 175 Ala Gly Val Asn. Giu Val Lys Giu Giu Leu Leu Giu Val Ile Asp Tyr 180 185 190 Leu Lys Lys Pro 195 1027 INFORMATION FOR SEQ ID NO:1461: SEQUENCE CHARACTERISTICS: LENGTH: 179 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...179 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1461 Met Lys Pro Leu His Phe Ser His Leu Asp Arg Glu Gin Ser Gly Asp 1 5 10 Val Gly Phe Ile Ile Lys Asn Leu Ile Phe Leu Gly Val Phe Ser Leu 20 25 Leu Gly Trp Leu Asn Thr Glu Tyr Phe Leu Trp Pro Ser Met Leu Glu 35 40 Leu Lys Lys Ile Leu Leu Glu Glu Asn Arg Lys Lys Ser Val Leu Glu 50 55 Tyr Ala Gin Arg His Phe Glu Thr Ala Leu Ala Asn Tyr Arg Asn Gin 65 70 75 SLys Glu Thr Ser Glu Ser Leu Leu Lys Ile Phe Asn Asp Glu Glu Ser 90 S Arg Arg Ile Leu Glu Lys Ile Leu Lys Lys Cys Phe Asp Ala Tyr Lys 100 105 110 Ile Lys Pro Leu Leu Ser Gin Asn Pro Ser Gin Lys Thr Gin Phe Phe 115 120 125 Ile Met Ala Arg Ala Ser Glu Leu Glu Lys Thr Tyr Leu Phe Phe Thr 130 135 140 Leu Ile Asn Lys Tyr Leu Pro Ser Ala Gin Ser Gin Leu Pro Leu Lys 145 150 155 160 Ile Ser Lys Asp Ser Asp Gly Leu Leu Val Gin Phe Gly Val Ser Ile 165 170 175 Asp Leu Gin INFORMATION FOR SEQ ID NO:1462: SEQUENCE CHARACTERISTICS: LENGTH: 452 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...452 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1462 1028 Phe Lys Arg Tyr Phe Ile Thr Met Lys Ile Phe Gly Thr Asp Giy Val 1 5 10 is Arg Gly Lys Ala Gly Val Lys Leu Thr Pro Met Phe Val Met Arg Leu 25 Gly Ile Ala Ala Gly Leu Tyr Phe Lys Lys His Ser Gin Thr Asn Lys 40 Ile Leu Ile Gly Lys Asp Thr Arg Lys Ser Giy Tyr Met Val Giu Asn 55 Ala Leu Val Ser Ala Leu Thr Ser Ile Gly Tyr Asn Val Ile Gin Ile 70 75 Gly Pro Met Pro Thr Pro Ala Ile Ala Phe Leu Thr Giu Asp Met Arg 90 Cys Asp Ala Gly Ile Met Ile Ser Ala Ser His Asn Pro Phe Giu Asp 100 10s 110 Asn Gly Ile Lys Phe Phe Asn Ser Tyr Gly Tyr Lys Leu Lys Giu Giu 115 120 125 Glu Giu Arg Ala Ile Glu Giu Ile Phe His Asp Glu Glu Leu Leu His 130 135 140 Ser Ser Tyr Lys Val Gly Giu Ser Val Gly Ser Ala Lys Arg Ile Asp 145 150 155 160 Asp Val Ile Giy Arg Tyr Ile Ala His Leu Lys His Ser Phe Pro Lys *165 170 175 :His Leu Asn Leu Gin Lys Leu Arg Ile Val Leu Asp Thr Ala Asn Gly 180 185 190 4.4 Ala Ala Tyr Lys Val Ala Pro Val Val Phe Ser Giu Leu Gly Ala Asp 195 200 205 Val Leu Val Ile Asn Asp Glu Pro Asn Gly Cys Asn Ile Asn Giu Gin 210 215 220 Cy Gly Ala Leu His Pro Asn Gin Leu Ser Gin Giu Vai Lys Lys Tyr 225 230 235 240 Arg Ala Asp Ile Gly Phe Ala Phe Asp Gly Asp Ala Asp Arg Leu Val *245 250 255 Val Ala Asp Asn Leu Gly Asn Ile Val His Gly Asp Lys Leu Leu Gly 260 265 270 Val Leu Gly Val Tyr Gin Lys Ser Lys Asn Ala Leu Ser Ser Gin Ala 275 280 285 Val Val Ala Thr Ser Met Ser Asn Leu Ala Leu Lys Glu Tyr Leu Lys 290 295 .300 Ser Gin Asp Leu Giu Leu Lys His Cys Ala Ile Gly Asp Lys Phe Val 305 310 315 320 Ser Glu Cys Met Arg Leu Asn Lys Ala Asn Phe Gly Gly Giu Gin Ser .325 330 335 Gly His Ile Ile Phe Ser Asp Tyr Ala Lys Thr Gly Asp Gly Leu Val 340 345 350 Cys Ala Leu Gin Val Ser Ala Leu Val Leu Giu Ser Lys Leu Val Ser 355 360 365 Ser Ile Mla Leu Asn Pro Phe Giu Leu Tyr Pro Gin Ser Leu Val Asn 370 375 380 Leu Asn Ile Gin Lys Lys Pro Pro Leu Giu Ser Leu Lys Gly Tyr Ser 385 390 395 400 Ala Leu Leu Lys Giu Leu Asp Gin Leu Glu Ile Arg His Leu Ile Arg 405 410 415 Tyr Ser Gly Thr Glu Asn Lys Leu Arg Ile Leu Leu Giu Ala Lys Asp 420 425 430 Glu Lys Leu Leu Glu Ser Lys Met Gin Giu Leu Lys Glu Phe Phe Glu 435 440 445 Gly Gin Leu Cys 450 INFORMATION FOR SEQ ID NO:1463: SEQUENCE CHARACTERISTICS: LENGTH: Ill amino acids 1029 TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE:.
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...111 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1463 Asn His Gin Arg Ile Arg Ser Arg Gin Gln Phe Arg Lys Pro Phe Asp 1 5 10 Pro Phe Arg Arg Ala Ser Glu Leu Lys Val Arg Ser Cys Lys Gin Ile 25 Phe Asp Lys Gly Leu Lys Pro Tyr Tyr Lys His Ser Val Cys Leu Lys 40 Pro Phe Phe Arg Phe Cys Phe Leu Lys Ile His Ala Tyr Gin Gin Arg 55 Tyr Arg Ala Phe Ala Leu Thr Leu Phe Ser Cys Lys Phe Phe Asn Ala 65 70 75 Cys Lys Ile Phe Ile Pro Ile Ile Asp Phe Lys Ile Val Phe Ile Pro 85 90 Ile Leu Lys His Gin Ala Lys Leu Lys Arg Val Ser Asn Ala Tyr S100 105 110 INFORMATION FOR SEQ ID NO:1464: SEQUENCE CHARACTERISTICS: LENGTH: 200 amino acids TYPE: amino acid TOPOLOGY: linear
*S
(ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...200 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1464 Lys Arg Met Lys Glu Ser-Phe Tyr Ile Glu Gly Met Thr Cys Thr Ala 1 5 10 Cys Ser Ser Gly Ile Glu Arg Ser Leu Gly Arg Lys Ser Phe Val Lys 25 Lys Ile Glu Val Ser Leu Leu Asn Lys Ser Ala Asn Ile Glu Phe Asn 40 Glu Asn Glu Thr Asn Leu Asp Glu Ile Phe Lys Leu Ile Glu Lys Leu 55 Gly Tyr Ser Pro Lys Lys Thr Leu Ala Glu Glu Lys Lys Glu Phe Phe 70 75 Ser Pro Asn Val Lys Leu Ala Leu Ala Val Ile Phe Thr Leu Phe Val 90 Val Tyr Leu Ser Met Gly Ala Met Leu Ser Pro Ser Leu Leu Pro Glu 1030 Ser Gin Ile 145 Leu Cys Ile Leu Leu 115 Leu Ile 130 Gin Gly Ile Ala Ile Trp, Ile Ile 195 100 Thr Gly Phe Ile Phe 180 Leu Asn Leu Ala 150 Thr Pro Ala His Ile 135 Leu Ser Ile Cys His 120 Val Trp Ala Ile Ala 200 110 Asn Ala Cys Leu 125 Arg Asp Phe Tyr Asn Met Ser Ser 160 Ala Cys Gly Asn 175 Gly Leu Met Gly 190 a.
a. INFORMATION FOR SEQ ID NO:i465: SEQUENCE CHARACTERISTICS: LENGTH: 241 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: H6licobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .241 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1465 Lys C 1 Phe Ser Ile Ser Gly' Gly.
Ile Ser Cys 145 Lys Asn Phe Glu Arg 225 rr ger Leu so
LYS
Val Arg Arg Phe 130 Val Leu Ile Ile Ala 210 Trp Ala Tyr( Asp Phe Ala Ile Leu Ile Leu Phe Arg Leu 195 Leu Ser Gln Gly Gly Pro Gly 100 Ala Gly Leu Leu Tyr 180 Val Ser
S
Ser Phe Leu Ile Ser Met Arg Ile Asp Gly 165 Pro Leu Val Ile Val1 Asp Giu 70 Leu Ala Phe Pro Asn 150 Phe Asn Ile Phe Phe Met Gly 55 Phe Ile Val Asn Ile 135 Lys Ile Phe Phe Met 215 Leu Ala 40 Arg Asp Thr Ser Ile 120 Pro Tyr Val Lys Leu 200 Gly Gly 25 Cys Val Ser Tyr Ala 105 Ser Ala His Leu Lys 1BS Ser Let; Met Trp Ala Leu Phe 90 Leu Thr Ala Phe Leu 170 Val Leu Met Liau Arg Ala 75 Phe Asn Ala Leu 155 C ly Lys Val Leu Phe 235 Ser Val Leu Asp Val1 Val Thr Val 140 Giu Val1 Trp Phe Ile 220 Ile Val1 Thr Val Gly Ile Ser 125 Leu Gly Leu Asn Val1 205 Tyr Phe Ala Asn Val Tyr Phe 110 Asp Val Asn Met Leu 190 Arg Gly Tyr Ser Thr Ala Asn Gly Pro Val Thr Val 175 Lys Pro Ile Ala Leu Thr Phe Phe Ala Tyr Leu Glu 160 Ser Leu Leu Ile Ser 240 lu Ser Leu Met Pro Ile Asn Pro Leu Tyr Leu Phe Pro Asn Leu Ile Phe Leu Met .230 Val Lys Ile Thr Asn Lys Asn Lys 1031.
Ala INFORMATION FOR SEQ ID NO:i466: SEQUENCE CHARACTERISTICS: LENGTH: 251 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: miscfeature LOCATION .251.
(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1466
*S
S
S
S
S 5 *5 5 *5*S *5S*
S
*5SS Ser Ser Arg Phe 65 Phe Asn Leu Leu 145 Pro Giu Giu Leu Ile 225 Leu Leu Ile Val Leu Asp Gin His Thr
LYS
130 Phe Asn His Ser Glu 22.0 Gin Glu Pro Ala Ser Glu Asn Ala Pro Leu Pro Ser Sen Val Phe Ser Val Gly 35 Ser Leu Ser Asn Asn 115 Arg Sen Glu Ala Leu 195 Glu Lys Ile Ala 20
LYS
Phe
LYS
Phe Leu 100 Giu Phe Ala Sen Leu 180 Asp Asn Gly 5 Leu Ile Gly Ala Asp 85 Ile Arg Leu Phe Ser 165 Phe Ser Phe Arg Asp 245 Ser Pro Leu Asp 70 Leu Asp Asp Asp Lys 150 Gly Glu Lys Lys Lys 230 Ile Leu Ser Leu 55 Leu Glu Cys Ile Asn 135 Arg Phe Ala Ile Ser 215 Asn Lys Lys Gly 40 Lys
LYS
Val Asn Val 120 Pro Leu Sen Phe Glu 200 Val Phe Glu 10 Ile Asp 25 Sen Lys Ile Ile Asn Leu Leu Giu 90 Leu Ser 105 Lys Ile Lys Asn Ala Asn Thr Ser 170 Asn Ala 185 Ala Tyr Leu Val Leu Trp Ile Ala 250 Sen Asp Ala Phe 75 Lys Ile Ile.
Ala Ile 155 Leu Ile Phe Met Gly 235 Ile Leu Pro His Glu Phe Ile Gln Gln 140 Asn Phe Lys Gly Asp 220 Val Phe Phe Lys Leu Arg Lys 125 Lys Lys Lys Thr Leu 205 Lys Tyr Sen Ala Gly Val Leu Ser 110 Val1
LYS
Asp Glu Ser 190 His Asp Gin Leu Leu Leu Gly Glu Val Lys Giu Arg Leu 17S Thr Ala Ile Ser Phe Arg Giu Val Arg Leu Ala Leu Asn 160 Gin Phe Pro Glu Phe 240 INFORMATION FOR SEQ ID NO:1467: Wi SEQUENCE CHARACTERISTICS: LENGTH: 594 amino acids TYPE: amino acid TOPOLOGY: linear 1032 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...594 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1467 Val Val Phe Lys Ile Leu Ser Leu Trp Leu Gly Val Phe Cys Phe Leu 1 5 10 Arg Ala Thr His Leu Tyr Leu Gly Glu Glu Pro Lys Tyr Lys Asp Asn 25 Phe Thr His Phe Glu Tyr Ala Asn Pro Asn Ala Arg Lys Gly Gly Val 40 Leu Arg Asn Asp Ala Ile Gly Thr Phe Asp Ser Leu Asn Pro Phe Ala 55 Leu Lys Gly Thr Lys Ala Glu Gly Leu Asp Leu Ile Tyr Asp Thr Leu 65 70 75 *0*0 Met Val Gin Ser Leu Asp Glu Pro Phe Ala Glu Tyr Pro Leu Ile Ala 85 90 Lys Asp Ala Glu Val Ala Lys Asp Asn Ser Tyr Val Ile Phe Thr Leu S100 105 110 Asp Lys Arg Ala Arg Phe Ser Asn Asn Ala Pro Ile Leu Ala Ser Asp 115 120 125 SVal Lys Phe Ser Phe Asp Thr Ile Met Lys Leu Gly Ser Pro Leu Tyr 130 135 140 Arg Gin Tyr Tyr Gin Asp Val Lys Lys Ala Val Ile Leu Asp Lys His 145 150 155 160 SHis Val Lys Phe Ile Phe Lys Thr Thr Glu Asn Lys Glu Leu Pro Leu 165 170 175 Ile Leu Gly Gin Leu Gin Ile Phe Ser Lys Lys Ala Phe Gin Lys Asp 180 185 190 Tyr Phe Glu Lys Asn Pro Leu Leu Ile Pro Val Ser Ser Gly Pro Tyr 195 200 205 S Val Ile Ala Ser Phe Asp Val Gly Lys Lys Ile Thr Tyr Gin Arg Asn 210 215 220 Pro Asn Tyr Trp Ala Lys Asn Leu Pro Ser Arg Lys Gly Gin Phe Asn S 225 230 235 240 Phe Asp Gin Ile Lys Phe Giu Tyr Tyr Lys Asp Glu Thr Val Ala Leu 245 250 255 Gin Ala Phe Leu Ser Gly Ala Tyr Asp Trp Arg Leu Glu Ser Thr Ala 260 265 270 Lys Val Trp Ala Arg Gly Tyr Val Gly Lys Ala Met Asp Asn Lys Lys 275 280 285 Ile Thr Lys Tyr Leu Ile Ala His Lys Met Pro Ser Gly Met Gin Gly 290 295 300 Phe Phe Phe Asn Thr Arg Arg Glu Ile Phe Lys Asp Lys Arg Val Arg 305 310 315 320 Glu Ala Leu Phe Tyr Ala Phe Asp Phe Glu Trp Ala Asn Lys Asn Leu 325 330 335 Phe Phe Ser Gin Tyr Lys Arg Thr Thr Ser Phe Phe Ser Asn Ser Ile 340 345 350 Tyr Ala Ser Pro Pro Leu Pro Ser Pro Giu Glu Lys Ala Leu Leu Ala 355 360 365 Pro Tyr Glu Lys Ser Leu Asp Giu Arg Val Phe Lys Glu Pro Tyr Ile 370 375 380 Val Pro Arg Thr Asp Gly Pro Asp Val Leu Gly Tyr Asn Leu Arg Glu 385 390 395 400 Asn Leu Lys Tyr Ala Gin Lys Leu Leu Glu Ser Ala Gly Phe Ser Tyr 405 410 415 1.033 Lys Leu Lys Leu 465 Val Tyr Arg Ala Val 545 Ser Pro Asn Met Leu Leu 435 Asn Leu 450 Ser Gin Gly Val Phe Gly Ile Ser 515 Lys Asp 530 Leu Leu Arg Ile Tyr Gly Lys Arg 420 Asn Arg Tyr Ile Ser 500 Ser Tyr Arg Ala Phe 580 Leu Val Asp Lys Asn Asri Lys Pro Phe Ser Phe Thr Pro Leu Asn 470 Gin Ser Ala Glu Phe 550 Tyr Pro 425 o iu Giu Lys Phe Ala 505 Asp Ala Ile Ile Trp 585 Ala Ile 460 Asp Asn Thr Giu Gin 540 Phe Pro Lys Leu 445 Gin Phe Giu Arg Arg 525 Ala Tyr Giu Lys 430 Ala Arg Asp Gin Asn 510 Ile Met Leu Ile Giu 590 Ala Asp Ile 480 Phe Ala His Arg As n 560 Pro Gly S. S
S
*5
S
INFORMATION FOR SEQ ID NO:1468: SEQUENCE CHARACTERISTICS: LENGTH: 201 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1. 201 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i468 Ser Vai Ile Gly Val Tyr Ile Ile Sen Leu Lys Glu Ser Gin Arg Arg 1 Leu Arg Phe Ser Leu Leu His Val Val Asp Cys Giu Asp Gly Asp Phe Arg 130 Leu Thr Val Lys Trp Cys Gin Met 115 Leu Pro 5 Giu Lys Phe Gin Leu Leu Tyr His Tyr Leu Pro Val 100 Gin Ala Tyr Gly Lys Glu Leu Asp 40 Leu Val Tyr Leu Asp 120 Trp Phe 10 Ser Ile Asn Ala Leu 90 Asp Leu Tyr Pro Asn Ser Ala G ly Trp Asp Lys His Phe Giu Pro Gin Leu Lys Val Sen Giu 140 Asp Lys Lys Ser Thn Giu Thr Pro 125 Thr His Phe His Leu Leu Cys Leu 110 Phe Lys Ser Lys Gin Leu Pro Val Giu Asp Phe Phe 1034 145 150 155 160 Asn Asn Pro Ile Leu Glu Lys Phe Lys Lys Phe Phe Asp Val Ser Arg 165 170 175 Phe Leu Asn Leu Ser Thr His Lys Val Ile His Leu Tyr Ser Gin Lys 180 185 190 Asn Thr Lys Lys Leu Leu Arg Asn Ala 195 200 INFORMATION FOR SEQ ID NO:1469: SEQUENCE CHARACTERISTICS: LENGTH: 540 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori
FEATURE:
NAME/KEY: misc -feature LOCATION .540 :9 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1469 P he Ser Glu Arg Asp Phe Glu Leu Phe Arg Gin Lys Thr Asn Pro Tyr 9 1 5 10 Giu Axg Cys Ser Cys Gly Phe Gly Phe Lou Ser Asp Ala Ser Lys Arg .9.20 25 Ser Lou Asn Pro Thr Leu Met Met Asn Asn Asn Asn Thr Lou Pro Lys 40 Pro Leu Glu Giu Ser Leu Asp Leu Lys Glu Phe Ile Ala Leu Phe Lys 55 Thr Phe Phe Ala Lys Giu Arg Gly Sn Ile Ala Leu Glu Asn Asp Lou 70 75 Lys Gin Ala Phe Thn Tyr Lou Asn Glu Val Asp Ala Ile Gly Leu Pro .9.85 90 Ala Pro Lys Sen Val Lys Giu Her Asp Leu Ile Val Val Lys Leu Thn 100 105 110 Lys Leu Gly Thn Lou His Leu Asp Glu Ile Tyr Glu Ile Val Lys Arg 115 120 125 Leu Arg Tyr Ile Val Val Leu Gin Asn Ala Phe Lys Pro Phe Thr His 130 135 140 Leu Lys Pho His Giu Arg Leu Asn Ala Ile Ile Lou Pro Pro Phe Phe 145 150 155 160 Asn Asp Leu Ile Leu Lou Leu Asp Asp Giu Gly Gin Ile Lys Gin Gly 165 170 175 Ala Asn Ala Thr Lou Asp Ala Lou Asn Glu Ser Leu Asn Arg Lou Lys 180 185 190 Lys Giu Sen Thn Lys Ile Ile His His Tyr Ala His Ser Lys Giu Leu 195 200 205 Ala Pro Tyr Lou Val Asp Thn Gin Ser His Leu Lys His Gly Tyr Glu 210 215 220 Cys Leu Leu Lou Lys Ser Gly Phe Ser Ser Ala Ile Lys Gly Val Val 225 230 235 240 Leu Glu Arg Ser Ala Asn Gly Tyr Phe Tyr Leu Leu Pro Glu Her Ala 245 250 255 Gin Lys Ile Ala Gin Lys Ile Ala Gin Ile Gly Asri Glu Ile Asp Cys 260 265 270 Cys Ile Val Glu Met Cys Gin Thr Lou Sen Arg Ser Leu Gin Lys His 275 280 285 1035 Leu Leu Phe Leu Lys Phe Leu Phe Lys Glu Phe Asp Phe Leu Asp Ser 290 295 300 Leu Gin Ala Arg Leu Asn Phe Ala Lys Ala Tyr Asn Leu Glu Phe Val 305 310 315 320 Met Pro Ser Phe Thr Gin Lys Lys Met Ile Leu Glu Asn Phe Ser His 325 330 335 Pro Ile Leu Lys Glu Pro Lys Pro Leu Asn Leu Lys Phe Glu Lys Ser 340 345 350 Met Leu Ala Val Thr Gly Val Asn Ala Gly Gly Lys Thr Met Leu Leu 355 360 365 Lys Ser Leu Leu Ser Ala Ala Phe Leu Ser Lys His Leu Ile Pro Met 370 375 380 Lys Ile Asn Ala His His Ser Thr Ile Pro Tyr Phe Arg Glu Ile His 385 390 395 400 Ala Ile Ile Asn Asp Pro Gin Asn Ser Ala Asn Asn Ile Ser Thr Phe 405 410 415 Ala Gly Arg Met Lys Gin Phe Ser Ala Leu Leu Ser Lys Glu Asn Met 420 425 430 Leu Leu Gly Val Asp Glu Ile Glu Leu Gly Thr Asp Ala Asp Glu Ala 435 440 445 Ser Ser Leu Tyr Lys Thr Leu Leu Glu Lys Leu Leu Lys Gin Asn Asn 450 455 460 Gin Ile Val Ile Thr Thr His His Lys Arg Leu Ser Val Leu Met Ala o* 465 470 475 480 Glu Asn Lys Glu Val Glu Leu Leu Ala Ala Leu Tyr Asp Glu Glu Lys 485 490 495 S* Glu Arg Pro Thr Tyr Thr Phe Leu Lys Gly Val Ile Gly Lys Ser Tyr 500 505 510 Ala Phe Glu Thr Ala Leu Arg Tyr Gly Val Pro Pro Phe Leu Ile Glu 515 520 525 Lys Arg Lys Pro Ser Met Ala Lys Ile Arg Lys Asn 530 535 540 *o* INFORMATION FOR SEQ ID NO:1470: SEQUENCE CHARACTERISTICS: LENGTH: 455 amino acids ,9 TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...455 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1470 Lys Leu Thr Glu Lys Ile Met Leu Glu Thr Pro Lys Val Leu Leu Lys 1 5 10 Asn Leu Gin Asp Cys Lys Ile His Phe Ile Gly Ile Gly Gly Ile Gly 25 Ile Ser Gly Leu Ala Lys Tyr Leu Lys Ala Gin Gly Ala Lys Ile Ser 40 Gly Ser Asp Ile Ala Ile Ser Pro Ser Val Lys Tyr Leu Lys Ala Leu 55 Gly Val Glu Ile Asn Ile Pro His Asp Pro Lys Ala Ile Asn His Gin 70 75 Asp Val Ile Ile His Ser Ala Ile Ile Lys Glu Asp Asn Thr Glu Ile 1036 90 Gin Arg Ala Lys Giu Leu Giu Ile pro Ile Leu Ser Arg Lys Asp Ala 100 105 110 Leu Tyr Ser Ile Leu Lys Asp Lys Arg Val Phe Ser Val Cys Gly Ala 115 120 125 His Gly Lys Ser Ser Ile Thr Ala Met Leu Ser Ala Ile Cys Pro Ala 130 135 140 Phe Gly Ala Ile Ile Gly Ala His Ser Lys Giu Phe Asp Ser Asn Val 145 1SO 155 1so Arg Giu Ser Ala Asp Met Ser Leu Val Phe Glu Ala Asp Giu Ser Asp 165 170 175 Ser Ser Phe Leu Phe Ser Asn Pro Phe Cys Ala Ile Val Pro Asn Thr 180 .185 190 Giu Pro Giu His Leu Giu His Tyr Asp His Asp Leu Giu Arg Phe Phe 195 200 205 Phe Ala Tyr Lys Tyr Phe Leu Asp His Ala Gin Lys Arg Val Ile Tyr 210 215 220 Lys Giu Asp Pro Phe Leu Lys Asn Tyr Ser Lys Asp Ala Ile Val Leu 225 230 235 240 Giu Lys Lys Asp Ile Tyr Asn Ile Gin Tyr Ile Leu Lys Asp Gly Giu 245 250 255 Pro Tyr Thr Ser Phe Giu Leu Lys Asn Leu Gly Ala Phe Leu Val Trp *260 265 270 Gly Leu Gly Giu His Asn Ala Thr Asn Ala Ser Leu Ala Ile Leu Ser 275 280 285 Ala Leu Asp Giu Leu Asn Leu Giu Glu Ile Arg Asn Asn Leu Leu Asn 290 295 300 Phe Lys Gly Ile Lys Lys Arg Phe'Asp Ile Leu Gin Lys Asn Asp Leu ***305 310 315 320 Sle Leu Ile Asp Asp Tyr Ala His His Pro Thr Glu Ile Gly Thr Thr 325 330 335 Leu Lys Ser Ala Arg Ile Tyr Ala Asn Leu Leu Asn Thr Gin Giu Lys *340 345 350 Ile Ile Val Ile Trp Gin Ala His Lys Tyr Ser Arg Leu Met Asp Asn *355 360 365 Leu Giu Giu Phe Lys Lys Cys Phe Leu Giu His Cys Asp Arg Leu Ile 370 375 380 Ile Leu Pro Val Tyr Ser Ala Ser Giu Val Lys Arg Asp Ile Asp Leu 385 390 39.5 400 *Lys Ala His Phe Lys His Tyr Asn Pro Thr Phe Ile Asp Arg Val Arg 405 410 415 Lys Lys Gly Asp Phe Leu Giu Leu Leu Val Asn Asp Asn Val Val Giu .:420 425 430 Thr Ile Glu Lys Gly Phe Val Ile Gly Phe Gly Ala Gly Asp Ile Thr 435 440 445 Tyr Gin Leu Arg Gly Giu Met 450 455 INFORMATION FOR SEQ ID NO:1471: SEQUENCE CHARACTERISTICS: LENGTH: 67 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/ME: misc-feature 1037 LOCATION .67 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i471 Ala Val. Thr Ala Ile Leu Gly Trp Asp Giu Giu Gly Lys Leu Lys Phe 1 5 10 Gly Lys Ile Arg His Lys Tyr Leu Giu Thr Ser Asn Vai Asn Ala Gly 25 Asn Ala Leu Thr Asn Leu Ile Leu Met Gin Arg Gly Tyr Ser Met Asn 40 Ala Arg Ala Phe Gly Ala Gly Asp Asp Met Ile Lys Giu Ala Ile Ser 55 Leu Lys Lys INFORMATION FOR SEQ ID NO:1472: SEQUENCE CHARACTERISTICS: LENGTH: 186 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .186 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1472 Lys Leu His Arg Gly Sen Gin Lys Gin Asn Pro Ile Asn Asp Pro Thr i 5 10 is *Trp Giu Ile Val Gly Phe Asp Ser Ala Thr His. Lys Met Lys Sen Ala 25 Pro Met Thr Leu Asp Phe Lys Gly Asn Lys Leu Thr Tyr Sen Leu Asp 40 Lys Ser Giu Asn Met Ile Leu Thr Lys Leu Phe Tyr Gin Asp Sen Lys Leu Leu Lys Thr Sen Gin Giu Arg Lys Pro Arg Gly Ile Phe Arg Asp 70 75 Met Arg Ile Glu Giu Asn Gly Val Ile Ser Leu Ala Phe Sen Asn Gly 90 Val Val Giu Pro Val Ala Arg Ile Gly Ile Leu Ala Phe Thr Asn Asp 100 105 110 Gin Gly Leu Arg Lys Ile Gly Gly Asn Leu Tyr Glu Met Gin Glu Gly 115 120 125 Thr Ile Asn Gly Giu Asn Arg Pro Leu Sen Gly Asn Arg His Phe Arg 130 135 140 Val Gly Arg Arg Gly Gin Ala Gin Val Trp Glu Asn Gin Ala Gin Ile 145 150 155 160 Phe Arg Asn Glu Gin Ang Glu Cys Arg Giu Arg Pro Asn Gin Ser His 165 170 175 Phe Asn Ala Lys Ang Leu Phe Tyr Glu Arg 180. 185 INFORMATION FOR SEQ ID NO:1473: SEQUENCE CHARACTERISTICS: 1038 LENGTH: 172 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NPAME/KEY: misc-feature LOCATION 172 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1473 Trp, Met Phe Val. Val Lys Met Val Leu Gly Phe Leu Ile Leu Leu Sen 1 5 10 Pro Leu Cys Ala Thr Gly Leu Asp Ile Ser Gin Thr Asp Ile Ile Glu 25 Arg Ser Leu Asn Phe Leu Leu Phe Val Gly Ile Leu Trp TIyr Phe Leu 40 Ala Lys Arg Leu Ang Ser Phe Leu His Ser Lys Ser Leu Glu Ile Ser 55 *Lys Arg Leu Giu Giu Ile Gin Ala Gin Leu Lys Val Ser Lys Glu His 70 75 **.Lys Lys Lys Leu Leu Lys Giu Leu Giu Gin Ala Lys Glu Lys Aia Giu 90 .Leu Ile Ile Ser Asp Ala Asn Lys Glu Ala Tyr Thr Ile Thr Gin Lys 100 105 110 Tyr Glu Leu Gin Thr Lys Met Asp Val Giu Asn Leu Ile Lys Asn Sen *115 120 125 Lys Ala Leu Met Asp Leu Glu Val Lys Lys Ile Lys Arg Giu Leu Val 130 135 140 Giu Sen Val Phe Lys Asp Leu Arg Giu Sen Lys Lys Val Ser Phe Asn 3-45 150 155 160 Ala Gin Asp Cys Val Asn Ile Leu Lys Gin Arg Leu 165 170 INFORMATION FOR SEQ ID NO:1474: SEQUENCE CHARACTERISTICS: LENGTH: 248 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein ii)HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: miscjfeature LOCATION 1. 248 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1474 Met Gin Lys Ser Ile Phe Lys Ile Thr Leu Leu Leu Val. Phe Leu Phe 1 5 10 is Leu Arg Asn Ala Val Gly Leu Asp Asp Lys Lys Ala Ala Pro Lys Ser 25 1039 Val Gin Asn Thr Pro Lys Asn Leu Pro Pro Ile Gin Leu Arg Leu Asp 40 Gin Ala Tyr Glu Asp Leu Ile Lys Met Leu Asp Asn Met Gly Lys Ser 55 Thr Gin Tyr Glu Phe Pro Lys Ile Lys Glu Ile Leu Glu Gin Ser Glu 70 75 Glu Glu Trp Leu Gly Val Ala His Glu Glu Cys Val Ala Leu Val Met 90 Leu Ile Ser Pro Lys Ala Ser Ile Glu Asn Ser Pro Ile Tyr Lys Asn 100 105 110 Cys Tyr Glu Ala Tyr Val Lys Gin Arg Ile His Asp Leu Tyr Asp Phe 115 120 125 Tyr Ile Glu Gly Lys Lys Val Lys Arg Lys Ile Lys Lys Ala His Glu 130 135 140 His Glu Met Ala Leu Asn Lys Ser Gin Pro Leu Lys Lys Glu Pro Pro 145 150 155 160 Lys Ser Glu Asn Lys Lys Gly Leu Thr Lys Pro Ser Leu Lys Asp Ala 165 170 175 Lys Ile Pro Lys Gly Tyr Tyr Leu Gin Ile Gly Ala Phe Leu Asn Ser 180 185 190 Pro Ser Lys Asp Phe Leu Gin Thr Leu Lys Thr Phe Pro His Gin Met 195 200 205 Glu G l u Lys Asp Ser Leu Thr His Tyr Leu Ile Gly Pro Tyr Lys Thr 210 215 220 Lys Glu Glu Ala Leu Lys Gin Leu Glu Asn Ala Ala Lys Ser Phe Lys 225 230 235 240 Asn Lys Pro Ala Leu Val Glu Lys 245 INFORMATION FOR SEQ ID NO:1475: SEQUENCE CHARACTERISTICS: LENGTH: 227 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...227 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1475 Ser Gly Cys Tyr Phe Glu Ser Asn Ser Asp Val Tyr Val Val Ile Ile 1 5 10 Gly Leu Ala Asp Gin Lys Ile Gly Val Ile Val Asp Tyr Leu Ile Gly 25 Gin Glu Glu Val Val Ile Lys Ser Leu Gly Tyr Tyr Leu Lys Asn Thr 40 Arg Gly Ile Ala Gly Ala Thr Val Arg Gly Asp Gly Lys Ile Thr Leu 55 Ile Val Asp Val Gly Ala Met Met Glu Met Ala Lys Ser Ile Lys Val 70 75 Asn Ile Thr Thr Leu Met Asn Glu Ser Glu Asn Thr Lys Ser Lys Asn 90 Ser Pro Ser Asp Tyr Val Val Leu Ala Ile Asp Asp Ser Ser Thr Asp 100 105 110 Arg Ala Ile Ile Arg Lys Cys Leu Lys Pro Leu Gly Ile Thr Leu Leu 1040 Giu Lys 145 Gly Leu Arg Gly Asp 225 Ala 130 Ile Tyr Pro Gly Giu 210 Gin 115 Thr Asn Gly Pro Asp Ala Thr Phe Ala 165 Leu Ile Ala 180 Val Giu Ser 195 Tyr Leu Thr Ser Leu Giu 135 Ile Leu 1S0 Ser Glu Val Thr Gly Met Thr Val 215 120 Giy Leu Glu Val Asp Ile Val Arg Lys 170 Ser Arg Val 185 Thr Giu Tyr 200 Vai Lys Arg Met Glu 155 Tyr Thr Ile Ser Leu 140 Met Asn Lys Thr Ile 220 125 LYS Asn Pro Lys Lys Phe Thr Asp 190 Lys Pro 205 LYS Leu Gly Asp Met Asp 160 Lys Asn 175 Arg Met Tyr Ser Glu Gly 4 S. *4 4 0*
S
.5 INFORMATION FOR SEQ ID NO:1476: SEQUENCE
CHARACTERISTICS:
LENGTH: 276 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .276 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1476 Met Thr Leu Sen Gin Ala Leu Asn Lys Aia Lys Lys 1 5 10 Lys Gly Phe Ang Gly Giy Leu Glu Ser Giu Ile Leu 20 25 Leu Gin Lys Giu Arg Val Phe Leu His Thr His Giu 35 40 Ser His Giu Giu Glu Thr Arg Phe Phe Glu Leu Val so 55 60 Asn Asp Cys Pro Ile Giu Tyr Leu Leu Gly Sen Cys 65 70 75 Arg Ser Phe Phe Val Asn Giu His Val Leu Ile Pro 90 Glu Ile Leu Val Gin Lys Ala Leu Asn Ile Ile Sen 100 105 Lys Giu Ile Gly Glu Ile Gly Ile Gly Ser Gly Cys 115 120 Leu Ala .Leu Giu Asn Pro Asn Leu Sen Ile Tyr Ala 130 135 140 Pro Lys Ala Leu Glu Val Ala Leu Lys Asn Ile Giu 145 ISO 155 Lys Giu Ang Val Phe Leu Lys Gin Thr Arg Leu Trp 165 170 Giu Leu Ser Pro Leu Gly Phe Val His Leu Glu Leu Gly Lys Arg Leu Asp Phe Tyr Gly Arg Pro Giu Thr Gin Tyr His Leu 110 Val Ser Val Sen 125 Sen Asp Ile Sen Arg Phe Cys Leu 160 k.sp His Met Pro 175 kl1a Ang Asn Tyr 190 kla Leu Phe Gly ~he Leu Ala Ala .Lnr Pro dly IlLe Leu Val1 210 Glu 195 Lys Met 180 Lys Gly Val1 Val1 Giu Ser Leu Ile 215 Tyr Ile His GIU Ile Val 220 2 2
I
1041 Lys Leu Lys Ile Pro Phe Leu Val Cys Glu Met Gly Tyr Asp Gin Leu 225 230 235 240 Lys Ser Leu Lys Giu Cys Leu Glu Phe Cys Gly Tyr Asp Ala Giu Phe 245 250 255 Tyr Lys Asp Leu Ser Gly Phe Asp Arg Gly Phe Val Gly Val Leu Lys 260 265 270 Ser Phe Leu Arg 275 INFORMATION FOR SEQ ID NO:1477: SEQUENCE CHARACTERISTICS: LENGTH: 188 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc__feature LOCATION 1 .188 :2(xi) SEQUENCE DESCRIPTION: SEQ ID NO:i477 Lys Ala Val Leu Phe Asn Pro Leu Pro Thr Lys Arg Ser Val Met Pro 1 5 10 *His Ser Lou Lys Lys Arg Phe Lou Ile Val Tyr Thr Lou Ser Thr Lou 25 Lou Leu Val Gly Val Lou Lou Ala Leu Phe Phe Phe Tyr Ala Lys Asn 40 Msn Leu Leu Glu Msn Thr Gin Ile Mrg Met Gin Tyr Thr Ala Asp Ala so 55 Ile Ala Lys Ser Lou Leu Glu Lou Msn Msn Ala Ser Ser Leu Giu Pro 70 75 Leu Lys Ile Lou Glu Giu Mrg Phe Lys Msn Thr Pro Phe Val Leu Lou 90 *Asp Ala Asp Msn Mrg Val Lys Pho Ser Msn Ile Gly Val Phe Val Ala 100 105 110 Ser Phe Lys Msn Asp Ala Lou Ile Lys Thr Pro Tyr Phe Ala Lou Lys ys 115 120 125 too LysGin Gly Phe Tyr Leu Thr Asp Ser Ala Pro Thr Msn Arg Leu Gly 130 135 140 Val Ser Lys Ile Ilie Ile Ala Giu Giu Giu Ile Gin Lys Ile Phe Ile 145 150 155 160 Pro Lou Tyr Lys Met Ile Gly Tyr Val Phe Leu Gly Ala Ser Lou Phe 165 170 175 Val Ala Lou Ile Ala MeetTrp Leu Tyr Lys Ile Pro 180 185 INFORMATION FOR SEQ ID 14:1478: SEQUENCE CHARACTERISTICS: (A).LENGTH: 408 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein 1042 (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAIAE/KEY: misc_feature LOCATION 1 .408 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i478 Asn Met Leu Asp Ile Trp Ile Asp Met Ile Ile Cys Ile Phe Tyr Leu 1 5 10 Leu Phe Phe Thr Thr Pro Tyr Ile Val Gly Asp Ile Leu Gin Leu Lys 25 Phe Ile Arg Gin Lys Leu Cys Giu Lys Pro Vai Leu Leu Pro Gin Lys 40 Asp Tyr Giu Giu Ala Giy Asn Tyr Ala Ile Arg Lys Met Gin Leu Ser 55 Ile Ile Ser Gin Ile Leu Asp Giy Vai Ile Phe Ala Gly Trp Val Phe 70 75 Phe Gly Leu Thr His Leu Giu Asp Leu Thr His Tyr Leu Asn Leu Pro 90 Glu Thr Leu Gly Tyr Leu Vai Phe Ala Leu Leu Phe Leu Ala Ile Gin 100 105 110 Ser Val Leu Ala Leu Pro Ile Ser Tyr Tyr Thr Thr Met His Leu Asp 115 120 125 Lys Giu Phe Gly Phe Ser Lys Vai'Ser Leu Ser Leu Phe Phe Lys Asp *Pe130 135 140 PePhe Lys Gly Leu Leu Leu Thr Leu Gly Val Gly Leu Leu Leu Ile 145 150 155 160 *Tyr Tbr Leu Ile Met Ile Ile Giu His Val Giu His Trp, Giu Ile Ser :*.165 170 175 Ser Phe Phe Val Vai Phe Val Phe Met Ile Leu Ala Asn Leu Phe Tyr 180 185 190 *Pro Lys Ile Ala Gin Leu Phe Asn Gin Phe Thr Pro Leu Asn Asn Arg 195 200 205 *Asp Leu Giu Ser Gin Ile Giu Ser Met Met Asp Lys Val Gly Phe Lys 210 215 220 Ser Gin Gly Ile Phe Vai Met Asp Ala Sen Lys Arg Asp Gly Arg Leu V* 225 230 235 240 *Asn Ala Tyr Phe Gly Gly Leu Giy Lys Asn Lys Arg Val Val Leu Phe *245 250 255 Asp Tbr Leu Ile Ser Lys Val Gly Thr Giu Gly Leu Leu Ala Ile Leu 260 265 270 y His Giu Leu Gly His Phe Lys Asn Lys Asp Leu Leu Lys Asn Leu oo0275 280 285 Gly Ile Met Gly Gly Leu Leu Ala Leu Val Phe Ala Leu Ile Ala His 290 295 300 Leu Pro Pro Leu Val Phe Glu Gly Phe Asn Val Ser Gin Thr Pro Aia 305 310 315 320 Ser Leu Ile Thr Ile Leu-Leu Leu Phe Leu Pro Val Phe Ser Phe Tyr 325 330 335 Ala Met Pro Leu Ile Giy Phe Phe Ser Arg Lys Asn Giu Tyr Asn Ala 340 345 350 Asp Lys Phe Gay Ala Ser Leu Sen Sen Lys Giu Thr Leu Ala Lys Ala 355 360 365 Leu Val Ser Ile Vai Asn Giu Asn Lys Ala Phe Pro Tyr Ser His Pro 370 375 380 Phe Tyr Val Phe Leu His Phe Thr His Pro Pro Lou Leu Giu Arg Lou 385 390 395 400 Lys Ala Leu Asp Tyr Glu Ile Glu 405 1043 INFORMATION FOR SEQ ID NO:i479: SEQUENCE CHARACTERISTICS: LENGTH: 144 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori A(ix) FEATURE: NAME/KEY miscjfeature LOCATION .144 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1479 Ile Arg Arg Ang Pro Ile Val Ser Asn Gin Leu Lys Asp Lou Phe Giu 1 5 10 is Arg Gin Lys Glu Ala Asn Ala Ser Sen Lys Gin Glu Asp Asn Glu Glu 25 Ile Leu Gin Phe Ile Gly Phe Ile Ile Gly Asp Glu Glu T~yr Ala Ile 40 Pro Ile Leu Asn Ile Leu Giu Ile Val Lys Pro Ile Gly Tyr Thr Arg .50 55 Val Pro Giu Thn Pro Asn T1yr Val Leu Gly Val Phe Asn Lou Arg Gly 65 70 75 :9Asn Val Phe Pro Leu Ile Ser Leu Arg Lou Lys Phe Gly Leu Lys Ala 90 Giu Lys Gin Asn Lys Asp Thr Arg Tyr Lou Val Vai Arg His Asn Asp *100 105 110 Arg Ser Leu Gly Phe Ser Ser Leu Ser Gly Lou Met Pro Ser Giu Ser 115 120 125 Aia Ser Thr Ile Asp Pro Ser Gin Lys Leu Cys Ala Ile Thr Ile Ile *130 135 140 INFORMATION FOR SEQ ID NO:1480: Ci) SEQUENCE CHARACTERISTICS: TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein Ciii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 299 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1480 Sen Phe Ser Ile Asn Ser Phe Lys Lys Ala Lys Gly Met Lys Ser Thr 1 5 10 Arg Ile Gly Ser Lys Ile Val Met Met Val Cys Ala Val Val Ile Val 25 Ile Sen Ala Val Met, Gly Val Ile Ile Ser Tyn Lys Val Giu Sen Val 1044 40 Leu Gin Ser Gin Ala Thr Glu Leu s0 Ser Phe Thr Leu Leu Lys Leu Leu Ala Met 130 Glu Asn 145 Asp Pro Ile Thr Asn Phe Lys Lys 210 Asn Pro 225 Asp Lys Gly Thr Ala Ile Ser Leu 290 Lys G 1u Arg Val 115 Asn Met Tyr Leu Phe 195 Ser Asn Arg Leu Gin 275 Ala Ile AMg Axg 100 Ser Met Thr Tyr Pro 180 Leu Asn Mrg Vai Ser 260 Pro Leu Gin Phe Met Ala Asp Asn Lys 165 Leu Asn Thr Glu Ala 245 Phe Gly 55 Gly Ile Met 70 Leu Ser Asp Leu Ser Giu Ile Tyr Thr 120 Ser Lys Ile 135 Gin Ile His 150 Giu Val Asn Met Gly Lys Ile Asp Ala 200 Phe Leu Met 215 Ile Gin Asp 230 Lys Ala Val His Ser Leu Asp Phe Phe 280 Asn Trp Giu 295 Leu Gin Lys Lys Arg Ile 75 Giu Asn Gly 90 Phe Leu Leu 105 Asn Asn Asn Ala Tyr Pro Ser Leu Lys 155 Giy Asp Lys 170 Asn Gin Asn 185 Phe Tyr Thr Gly Lys Asp Lys Ile Leu 235 Giu Tyr Tyr 250 Ser Giy Asn 265 Glu Giu Lys Ile Cys Gin Lys Phe Ala Ala Glu Asn 140 Ser Ile Val1 Asp Gly 220 Ser As n Thr Ala Gin Met Gly Ile Asn Asn Pro 110 Arg Met 125 Thr Ala Ile Thr Tyr Giy Ile Gly 190 Val Val 205 Arg Ile Ala Ile Gin Asn Glu Thr Leu Ala Asp His Ile Leu Arg Met 175 Aia Giy Leu Asn Giu 255 Phe Val1 Asn Thr Val1 Thr Asn Ser 160 Asp Leu Lys Ile Pro 240 Ala Leu Gly Asn Asn Gly Gin 9 *9 9 999 INFOMTION FOR SEQ ID NO:i481: Wi SEQUENCE CHARACTERISTICS: LENGTH: 101 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAMdE/KEY: misc-feature LOCATION .101 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:148i Gly Vai Phe Tyr Msn Ser Ser Leu Pro Gin Pro Pro Thr Lys Asri Pro 1 5 10 is Leu Thr Arg Giu Tyr Arg Phe Leu Lys Arg Leu Ser Leu Ile Tyr Aia 25 Ser Sen Phe Ile Val Phe Ile Leu Lys Asn Ala Leu Lys Leu Phe Leu 40 Ile Leu Leu Leu Met Leu Asn Lys Pro Lys Pro Leu Phe Leu Leu Leu 55 Val Lys Pro Phe Phe Tyr Leu Phe Asp Leu Val Ala His Leu Ser Thr 1-70 75 1045 Arg Ile Asp Leu Ile Asp Lys His Val Lys Val Tyr His His Gin Lys 90 His His His Lys Pro 100 INFORMATION FOR SEQ ID NO:1482: Wi SEQUENCE CHARACTERISTICS: LENGTH: 111 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .111 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1482 Phe Ile Thr Gly Ile Glu Ile His Pro Gly Ala Lys Ile Gly Arg Gly 1 5 10 Leu Phe Ile Asp His Gly Met Gly Val Val Ile Gly Glu Thr Thr Glu *20 25 Ile Gly Asp Asp Val Thr Ile Tyn His Gly Val Thn Leu Gly Gly Thn 40 *Gly Lys Phe Lys Gly Lys Arg His Pro Thr Leu Gly Asn Ang Val Val Val Gly Ala Gly Ala Lys Val Leu Giy Ala le-Cys Val Gly Asp Asp 70 75 Val Arg Ile Gly Ala Asn Ala Val Val Leu Ser Asp Leu Pro Thr Gly 90 Ser Thr Ala Val Gly Ala Lys Ala Lys Thr Ile Thr Lys Asp Arg 100 10s 110 INFORMATION FOR SEQ ID NO:1483: SEQUENCE CHARACTERISTICS: LENGTH: 377 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacten pyloni (ix) FEATURE: NAME/KEY: misc..feature LOCATION .377 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1483 Lys Gly Phe Leu dly Val Lys Lys Val Ile Val Phe Ile Lys Lys Lys 1 5 10 Gly Glu Met Val Val :Asn Sen Lys Val Gin Thr Leu Lys Val Phe Ser 1046 25 Lys Phe Phe Ser Asn Phe Lys Ile Thr Lys Leu Lys Asp Asn His Giu 40 Giu Ala His Lys Leu Phe Gly Giu Asn Ser Arg Lys Ala His Asp Thr so 55 Glu Ile Ile Tyr Ser Thr Leu Gin Val Val Pro Arg Tyr Ser Ile Glu 70 75 Thr Val Gly Phe Ser Leu Leu Ile Leu Ala Vai Ala Tyr Ile Leu Phe 90 Lys Tyr Gly Glu Ala Arg Met Val Leu Pro Thr Ile Ser Met Tyr Ala 100 105 110 Leu Ala Leu Tyr Arg Ile Leu Pro Ser Val Thr Gly Val Ile Ser Tyr 115 120 125 Tyr Asn Giu Ile Ala Tyr Asn Gin Leu Ala Thr Asn Val Val Phe Lys 130 135 140 Ser Leu Ser Lys Thr Ile Val Giu Giu Asp Leu Val Pro Leu Asp Phe 145 150 155 160 Asn Giu Lys Ile Thr Leu Gin As I le Ser Phe Ala Tyr Lys Ser Lys 165 170 175 His Pro Vai Leu Lys Asn Phe Asn Leu Thr Ile Gin Lys Gly Gin Lys 180 185 190 Ile Ala Leu Ile Gly His Ser Gly Cys Gly Lys Ser Thr Leu Ala Asp 195 200 205 Ile Ile Met Gly Leu Thr Tyr Pro Lys Ser Gly Giu Ile Phe Ile Asp 210 215 220 Asn Thr Leu Leu Thr Ser Giu Asn Arg Arg Ser Trp Arg Lys Lys Ile 225 230 235 240 Gly Tyr Ile Pro Gin Asn Ile Tyr Leu Phe Asp Gly Thr Val Gly Asp *245 250 255 Asn le Ala Phe Giy Ser Ala Ile Asp Giu Lys Arg Leu Ile Lys Val 260 265 270 *Cys Lys Met Ala His Ile Tyr Asp Phe Leu Cys Giu His Giu Gly Leu 275 280 285 Lys Thr Gin Val Giy Giu Gly Giy Ala Lys Leu Ser Gly Gly Gin Lys Gn290 295 300 GnArg Ile Giy Ile Ala Arg Ala Leu Tyr Asp Asn Pro Giu Ile Leu *305 310 315 320 Val Leu Asp Glu Ala Thr Ser Ala Leu Asp Asn Glu Thr Giu Ser Lys 325 330 -335 Ile Met Asp Giu Ile Tyr Gin Ile Ala Lys Asn Lys Thr Leu Ile Val 340 345 350 S le Ala His Arg Leu Ser Thr Ile Giu Arg Cys Glu Val Ile Ile Asp 355 360 365 Met Ser Gin His Lys Asp Asn Leu Gly 375 IFORMATION FOR SEQ ID NO:i484: SEQUENCE CHARACTERISTICS: LENGTH: 229 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1. 229 1047 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1484 Ala Tyr Lys Lys Gly Glu Ile Met Ala Leu Glu Val Val Leu Trp Asp 1 5 10 Phe Asp Gly Val Ile Phe Asp Ser Met His Leu Lys Tyr Glu Gly Phe 25 Lys Ala Leu Phe Gin Lys His Gly Asn Asp Ser Lys Glu Gly Leu Lys 40 Gin Phe Glu Val Tyr His Tyr Gln Ser Gly Gly Ile Ser Arg Asn Glu 55 Lys Ile Gin Tyr Phe Tyr Asn Glu Ile Leu Lys Thr Pro Ile Ala Gin 70 75 Glu Glu Ile Asp Ala Leu Ala Leu Glu Phe Gly Ala Ile Ile Glu Gin 90 Lys Leu Phe Asp Arg Gly His Leu Asn Ser Glu Val Met Ala Phe Ile 100 105 110 Asp Lys His Tyr Gin Asn Tyr Ile Phe His Ile Ala Ser Ala Ala Leu 115 120 125 His Ser Glu Leu Gin Val Leu Cys Glu Phe Leu Gly Ile Thr Lys Tyr 130 135 140 Phe Lys Ser Val Glu Gly Ser Pro Pro Asp Lys Pro Lys Ile Ile Ala 145 150 155 160 Asn Ile Ile Gin Lys Tyr Ala Tyr Asp Pro Ser Arg Met Leu Met Ile 165 170 175 Gly Asp Ser Val Asn Asp Tyr Glu Ser Ala Lys Ala Asn Lys Val Ala 180 185 190 Phe Leu Gly Tyr Asn Ser Lys Val Leu Lys Asn Leu Val Gly Gin Asp 195 200 205 Gly Tyr Gln Gly Lys Tyr Leu Glu Ser Phe Lys Gly Phe Asp Leu Gin 210 215 220 Asn Phe Ala Lys Glu 225 INFORMATION FOR SEQ ID NO:1485: SEQUENCE CHARACTERISTICS: LENGTH: 165 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...165 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1485 Asn Lys Ser Met Gin His Leu Val Leu Ile Gly Phe Met Gly Ser Gly 1 5 10 Lys Ser Ser Leu Ala Gin Glu Leu Gly Leu Ala Leu Lys Leu Glu Val 25 Leu Asp Thr Asp Met Ile Ile Ser Glu Arg Val Gly Leu Ser Val Arg 40 Gly Ile Phe Glu Giu Leu Gly Glu Asp Asn Phe Arg Met Phe Glu Lys 55 Asn Leu Ile Asp Glu Leu Lys Thr Leu Lys Thr Pro His Ile Ile Ser 70 75 Thr Gly Gly Gly Ile Val Met His Glu Asn Leu Lys Gly Leu Gly Thr 1048 90 Thr Phe Tyr Leu Lys Met Asp Phe Glu Thr Leu Ile Lys Arg Leu Asn 100 105 110 Gin Lys Glu Arg Glu Lys Arg Pro Leu Leu Asn Asn Leu Thr Gin Ala 115 120 125 Lys Glu Leu Phe Glu Lys Arg Gin Ala Leu Tyr Glu Lys Asn Ala Ser 130 135 140 Phe Ile Ile Asp Ala Arg Gly Gly Leu Asn Asn Ser Leu Lys Gln Val 145 150 155 160 Leu Gin Phe Ile Ala 165 INFORMATION FOR SEQ ID N0:1486: SEQUENCE CHARACTERISTICS: LENGTH: 325 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...325 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1486 Ile Phe Phe Lys Gly Leu Val Met Leu Ser Arg Asp Ile Val Gin Tyr 1 5 10 Ser Lys Ile Arg Thr Glu Leu Tyr Ala Tyr Leu Thr Tyr Leu Phe Ser 20 25 His Asn Ile Arg Asn His Leu Pro Glu Ile Thr Leu Asp Tyr Leu Asn 40 Arg Gin Ile Ser Lys Met Gin Ala Glu Ile Lys Met Ala Lys Ser Phe 50 55 Phe Val Leu Asp Ala Lys Gly Met Leu Met Leu Lys Pro Ser Gin Phe 70 75 Lys Glu Gin Gly His Lys Glu Gly Leu Leu Glu His Asp Leu Thr Glu 90 Gly Ile Glu Leu Glu Ser His Val Ser Phe Ser Asp Lys Tyr Tyr Phe 100 105 110 Tyr Gin Ala Val Asn Glu Lys Arg Cys Ile Leu Thr Asp Pro Tyr Pro 115 120 125 Ser Lys Lys Gly Asn His Leu Val Val Ser Ala Ser Tyr Pro Val Tyr 130 135 140 Asp Gin Asn Asn Asp Leu-Ala Phe Val Val Cys Leu Gin Ile Pro Leu 145 150 155 160 Arg Val Ala Ile Glu Ile Ser Ser Pro Ser Lys Tyr Phe Lys Thr Phe 165 170 175 Ser Glu Gly Ser Met Val Met Tyr Phe Met Ile Ser Ile Met Leu Thr 180 185 190 Leu Val Ser Leu Leu Leu Phe Val Lys Cys Ile Ser Ser Phe Trp Thr 195 200 205 Ala Ile Val His Phe Ser Ser Phe Asp Ile Lys Glu Val Phe His Pro 210 215 220 Ile Val Leu Leu Thr Leu Ala Leu Ala Thr Phe Asp Leu Val Lys Ala 225 230 235 240 Ile Phe Glu Glu Glu Val Leu Gly Lys Asn Ser Gly Asp Asn His His 245 250 255
I
1049 Ala Ile His Arg Thr Met Ile Arg Phe Leu Gly Ser Ile Ile Ile Ala 260 265 270 Leu Ala Ile Glu Ala Leu Met Leu Val Phe Lys Phe Ser Val Ser Glu 275 280 285 Pro Asp Lys Ile Thr Tyr Ala Val Tyr Leu Ala Ile Gly Val Ala Val 290 295 300 Leu Leu Ile Ser Leu Ala Ile Tyr Val Lys Phe Ala Tyr Ser Val Leu 305 310 315 320 Pro Lys Arg Glu Arg 325 INFORMATION FOR SEQ ID NO:1487: SEQUENCE CHARACTERISTICS: LENGTH: 188 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...188 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1487 Glu Ser Tyr Gin Thr Val Phe Thr Arg Gln Arg Tyr Tyr Gin Arg Leu 1 5 10 Phe Arg Arg Ala Val Cys Arg Asn Leu Arg Val Cys Glu Phe Thr Asn n. 20 25 Gln Asn Asn Lys Arg Gly Asp Cys Gln Arg Gln Gin Leu Phe Tyr Gly 40 Ala Tyr His Gly Glu Cys Leu Ser His Phe Arg Ile Ala Lys Thr His 55 Cys Gly Ala Ser Pro Phe Ile Val Ser Asp Phe Asn Phe Ile Gly Phe 65 70 75 Ile Val Pro Pro Ser Asn His Phe Ile Cys Gly Ser Gin Leu Lys Ser 90 Arg Pro Phe Arg Ala Ile Cys Leu Ala Arg Ile Ser Lys His Cys Gin 100 105 110 Ser Leu Phe Thr Leu Val Cys His Arg Val Phe Tyr Gly Val Pro Tyr 115 120 125 Phe Met Leu Gly Val Ile Glu Arg Tyr Tyr Phe Trp His Asp His Glu 130 135 140 Asn Pro Pro Ser Ile Gin Pro Ala Arg Tyr Arg Val Ser Gly Asn Cys 145 150 155 160 Asp Arg Val Cys Gly His-Tyr Phe Asn Arg Phe Gly Tyr His Gly Ala 165 170 175 Phe Arg Arg Asn Gin Pro Gly Leu Arg Tyr Asn Leu 180 185 INFORMATION FOR SEQ ID NO:1488: SEQUENCE CHARACTERISTICS: LENGTH: 444 amino acids TYPE: amino acid TOPOLOGY: linear 1050 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...444 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1488 Gly Val Leu Arg Phe Ser Ile Phe Phe Lys Val Val Ala Leu Phe Met 1 5 10 Ile Thr Leu Phe Ser Phe Gly Ala Phe Ala Tyr Tyr Phe Val Ser Ser 25 Gin Ile Ser His Glu Asn Tyr Gin Asn Glu Met Arg His Tyr Gin Phe 40 Val Thr Thr Ile Asn Glu Ile Leu Asn Asn Tyr Ser Asp Tyr Arg Ala 55 Ile Glu Asp Tyr Leu Tyr Lys Ile Gly Phe Arg Glu Thr Thr Ile Glu 70 75 Asn Leu Glu Lys Val Leu Ala Lys Arg Arg His Gin Leu His His Arg 90 Asn Ile Trp Tyr Ala Glu Val Phe Lys Phe Ser Asp Met Val Phe Ile 100 105 110 Leu Leu Lys Lys Asp Glu His Phe Val Leu Tyr Lys Asp Leu His Ser 115 120 125 Val Ser Tyr Arg Asn Tyr Phe Leu Ala Ile Thr Val Gly Leu Leu Leu 130 135 140 Ile Leu Phe Leu Phe Leu Phe Val Leu Gin Ser Leu Leu Pro Leu Arg 145 150 155 160 Glu Leu Arg Ser Gin Val Lys Arg Phe Ala Gin Gly Asp Lys Ser Val 165 170 175 Ser Cys Lys Ser Lys Gin Lys Asp Glu Ile Gly Asp Leu Ala Asn Glu 180 185 190 Phe Asp Asn Cys Ile Gin Lys Ile Asn Ala Met Asn Glu Ser Arg Val 195 200 205 Leu Phe Leu Arg Ser Ile Met His Glu Leu Arg Thr Pro Ile Thr Lys 210 215 220 Gly Lys Ile Leu Ser Ser Met Leu Lys Glu Glu Leu Ser Cys Lys Arg 225 230 235 240 Phe Ser Ser Ile Phe Asp His Leu Asn Met Leu Ile Glu Gin Phe Ala 245 250 255 Arg Ile Glu Gin Leu Ala Ser Lys Asn Tyr Gly Ser Asn Lys Glu Lys S* 260 265 270 Phe Leu Met Ser Asp Leu Ile Asp Lys Ile Glu Lys Met Leu Leu Ile 275 280 285 Asp Glu Asp Lys Lys Ser Pro Ile His Val Ser Ser Ser Asn Tyr Ile 290 295 300 Ile Glu Ala Asp Phe Glu Leu Phe Ala Ile Ala Leu Lys Asn Met Ile 305 310 315 320 Asp Asn Ala Ile Lys Tyr Ser Asp Asp Lys Gin Val Phe Leu Asp Phe 325 330 335 Ile Gly Asn Asn Leu Val Val Ser Asn Lys Ser Lys Pro Leu Lys Glu 340 345 350 Asp Phe Glu Lys Tyr Leu Gin Pro Tyr Phe Lys Ser Ser Asn Pro Ser 355 360 365 Gin Ala His Gly Phe Gly Leu Gly Met Tyr Ile Ile Lys Asn Ala Leu 370 375 380 Glu Ala Met Gly Leu Asn Leu Ser Tyr His Tyr Ser Asn Gly Arg Ile 385 390 395 400 Cys Phe Thr Ile His Asp Cys Val Phe Asn Ser Phe Tyr Asp Leu Glu 405 410 415 1051.
Ala Asp Asn Glu Glu Leu Pro Pro Pro Arg Lys Phe Giu Arg Gay Glu 420 425 430 Gay Asn Glu Gly Asn Arg Lys Ser Gin Leu Trp Gly 435 440 INFORMTION FOR SEQ ID NO:1489: SEQUENCE CHARACTERISTICS: LENGTH: 330 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc -feature LOCATION .330 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1489 Arg Lys Thr Lys Ang Giu Asn Met Phe Lys Arg Leu Arg Ang Leu Arg 1 5 10 is *Ser Ser Glu Asn Leu Arg Ala Met Val Arg Glu Thr Arg Leu Asn Ile 25 Asn Asp Phe Ile Ala Pro Leu Phe Val Ile Giu Ser Asp Ser Gay Ile 40 Lys Asn Giu Ile Sen Sen Met Pro Gly Val Tyr Gin Met Se Ile Giu so 55 Pro Leu Leu Lys Glu Cys Giu Glu Lou Val Gly Leu Gly Ile Lys Ala 70 75 *Val Leu Leu Phe Gly Ile Pro Lys His Lys Asp Ala Thr Gly Ser His 90 Ala Lou Asn Lys Asp His Ile Val Ala Lys Ala.Thr Arg Glu Ile Lys 100 105 110 Lys Arg Phe Lys Asp Leu Ile Val Ile Ala Asp Leu Cys Phe Cys Glu 115 120 125 Tyr Thr Asp His Gay His Cys Gay Ile Leu Glu Asn Ala Ser Val Ser 130 135 140 Asn Asp Lys Thr Leu Lys Ile Lou Asn Leu Gin Gly Leu Ile Leu Ala 145 150 155 160 *Giu Ser Gly Val Asp Ile Lou Ala Pro Sen Asn Met Met Asp Gly Asn 165 170 175 Val Leu Sen Leu Ang Lys Ala Leu Asp Lys Ala Gly Tyr Phe His Thr 180 185 190 Pro Ile Met Ser Tyr Ser Thr Lys Phe Ala Ser Ser Tyr Tyr Gly Pro 195 200 205 Phe Arg Asp Val Ala Asn S -r Pro Pro Ser Phe Gly Asp Ang Lys Sen 210 215 220 Tyr Gin Met Asp Tyr Ala Asn Gin Lys Giu Ala Leu Leu Glu Ser Leu 225 230 235 240 Giu Asp Glu Lys Gin Gay Ala Asp Ile Leu Met Val Lys Pro Ala Leu 245 250 255 Ala Tyr Leu Asp Ile Val Lys Giu Ile Arg Asp His Thr Leu Leu Pro 260. 265 270 Lou Ala Leu Tyr Asn'Val Sen Gly Glu Tyr Ala Met Lou Lys Leu Ala 275 280 285 Gin Lys His Asn Leu Ile Asn Tyr Glu Sen Val Leu Leu Glu Thr Met 290 295 300 Thr Cys Phe Lys Arg Ala Gly Ala Asp Met Ile Ile Ser Tyr His Ala 1052 315 320 305 310 Lys Glu Val Ala Asn Leu Leu Gin Arg Asn 325 330 INFORMATION FOR SEQ ID NO:1490: SEQUENCE CHARACTERISTICS: LENGTH: 362 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...362 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1490 a.
a. a a .aa.
a.
a a a. a Ser 1 Pro Asp Asp Thr Cys Lys Ser Leu Lys 145 Asn Asn Asp Ile Asp 225 Leu Ile Val Lys Asn 305 Ala Lys Leu Val Gly Met Ile Val Ile 130 Ile Ala Met Lys Leu 210 Ala Lys Ile Leu Leu 290 Gly Arg Ile Leu Ala Glu Asp Ile Ile Cys Asn Gln Ala Met Glu Ala 100 Val Ser Leu Glu Lys 180 Leu Ser Lys Gly Leu 260 Leu Pro 5 Gin Lys Leu Val Ser Asn Pro Gin Phe Cys 165 Asn Gn Ala Glu Lys 245 Pro Pro Phe Ser Thr Glu Pro 70 His Ile Lys Gly Ser 150 Gin Tyr Leu Gly Arg 230 Pro Gly Leu Lys Ala Gin Val 55 Lys Lys Arg Asn Phe 135 Ser Val Asn Lys Yal 215 Asn Val Asn Leu Ala 295 Tyr His Glu Thr 75 Leu Glu Asn Lys Leu 155 Asn Leu Leu Asp Tyr 235 Gin Cys Ser Ala Tyr 315 Gly Ile Cys Ile Ala Asn Tyr Ala 140 Val Ser Gly Gin Lys 220 Tyr Leu Leu Leu Pro 300 Val Phe Phe Val Val Pro Ala Gly 125 Phe Pro Val Val Gly 205 Asp Glu Asn Leu Asn 285 Leu Ala Met Gly Ile Ile Asp Leu Ile Lys Gly Val 175 Lys Asp Phe Val Ser 255 Leu Asp Leu Leu Gin Asp Met Glu Phe Asn Ala Leu Gin 160 Phe Asp Val Lys Asn 240 Ile Arg Phe Asn Phe 320 Lys Arg Thr His Leu Ile Leu Gly Asn 310 Ser Asn His Gin 1053 Pro Tyr Asn Asn Arg Tyr Giu Ser Gly Ala Ile Gin Ala Leu Ala 325 330 335 Val Asp Ser Ile Ala Leu Ile Asp Giu Gly Val Gly Leu Val Gin 340 345 350 Glu Ile Giu Ile Leu Arg Phe Giu Asn 355 360 INFORMATION FOR SEQ ID NO:i491: SEQUENCE CHARACTERISTICS: LENGTH: 211 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1..-211 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1491
C.
C
C
C.
C
a
C
C.
C C Gly 1
LYS
Asn Ser Thr 65 Asp Trp Phe Asn Leu 145 Asp
LYS
dly
LYS
Asn Tyr Gly Leu Glu Ile Arg Phe Met Pro Gly Ser dly His Giu Thr 130 Val le Val
LYS
Leu 210 Ile Phe 35 Ile Ala Ser Tyr
LYS
115 Met Asn Tyr Gly 195
LYS
Gly 20 Glu Tyr Axg Ile Pro iO0O Arg Ile Pro Gin Thr 180 Arg 5 Leu Pro Asp Ile His Leu Leu Asn 165 His Val Ala Val Giu Ile Asn 40 Asp T1yr Leu 55 Leu Lys Lys 70 Ser Lys Val Lys Leu Sen Gin Ile Gin 120 Arg Sen Pro 135 Arg Ile Val 150 Met Asp Leu Lys Asp Tyr Leu-Leu Giu 200 Leu 25 Ser Lys Ile Val Gin Asp Leu Asn 185 Glu Lys 10 Ser Lys Giu Thr Gly 90 His Phe
LYS
Asp Gin 170 Arg Lys Val Asn Ile Leu 75 Ile Thr Asp Ile Thr 155 Lys Ile Asn Giu Met Ala Val Leu Leu Leu Leu Gin His Val Thr Tyr Asp Lys Leu Asn Phe Leu 125 Leu Ang 140 Gin Lys Phe Phe Thn Leu Gly Ala 205 Ala Gly Asp Gin Ser Gin 110 Met Sen Gly Sen Ile 190 Tyr 1s Arg Gly Leu Asp Ile Asp Ala Phe Pro His 175 Leu Giu
LYS
Asp Phe Pro le Asp Ala Asn.
Val Leu 160 Ile Asp Leu INFORMATION FOR SEQ ID NO:1492: Wi SEQUENCE CHARACTERISTICS: LENGTH: 352 amino acids TYPE: amino acid TOPOLOGY: linear 1054 (ii) (iii) MOLECULE TYPE: protein HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...352 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1492 *2 4 Lys 1 Glu Ser Leu Lys Leu Thr Ile Thr Gly 145 Ser Ser Thr Pro Ala 225 Leu Asp Leu Thr Leu 305 Leu Ala Ser Glu Val Val Ala Ser Tyr Pro 130 Gly Val Gly Phe Met 210 His Gly Pro Asp Ile 290 Glu Lys Phe Leu Lys Ile Asn His Tyr 115 Gin Phe Ser ksp Ile 195 Val Ser Ala Lys Phe 275 Phe Asn Val Lys Asp Gly Asp Met Tyr 100 Asn Leu Lys Tyr Leu 180 Gly Leu Asp Ile Tyr 260 Ser Ser Leu Thr Val 340 Ala Leu Val Tyr Ala Ser 55 Thr Tyr 70 Ala Leu Ile Ala Ala Leu His Thr 135 Glu Ser 150 Glu Gly Phe Phe Gly Phe Gly Val 215 Asp Ala 230 Gly Gly Asn Ala Ser Ile Ile Pro 295 GlnLeu 310 Met Glu Ala His Asp Ile 40 Arg Thr Lys Pro Asp 120 Lys Ser Ser Thr Asp 200 Val Leu Asp Ser Gly 280 Lys Leu Lys Val Phe 25 Gin Gin Ile Ser Tyr 105 Arg Thr Ala Lys Pro 185 Thr Leu Leu Ile Ser 265 Phe Ile Gly Met Ser 345 10 Lys Glu Arg His Glu Ser Thr Ser 75 Leu Phe Leu Pro Glu Ala Leu Gin Ile Leu 155 Asp Leu 170 Phe Phe His Ala Asp Cys His Ala 235 Gly Glu 250 Lys Glu Glu Leu Thr Pro Leu Glu 315 Gly Phe 330 Val Tyr Val Asp Leu Cys Ile Ser 140 Gin His Asn Phe Glu 220 Val Trp Leu Leu Tyr 300 Lys Ile Val Ala Thr Pro His His Thr Pro Leu Trp Leu Ile Pro Arg Val Thr Tyr Lys 125 Ala Ala Lys Pro Ile 205 Phe Ile Phe Leu Glu 285 Lys Ser Gly Ser Leu Lys Asn Ala Leu Asp 110 Leu Leu Phe Leu Ala 190 Lys Gly Asp Pro Lys 270 Met Pro Gin Lys Val Val Ile Ala Arg Gin Thr Ile Asn Pro Thr 175 Lys Asp Leu Ala Asp 255 Ile Gly Ala Ile Gin Tyr Val Lys Leu Gly Gin Ala Gin Gin Asn 160 Thr Asp Lys Lys Ile 240 Asn Val Ala Ile Ser 320 Glu .4 r*4* 4 Gly Leu Leu Met Arg Tyr Lys Gin Lys Leu 350 INFORMATION FOR SEQ ID NO:1493: SEQUENCE CHARACTERISTICS: LENGTH: 205 amino acids TYPE: amino acid TOPOLOGY: linear 1055 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...205 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1493 Cys Leu Gly Met Cys Phe Ile Leu Lys Pro Phe Leu Ser Cys Leu Lys 1 5 10 Trp Ala Asn Pro Ser Leu Lys Pro Leu Ser Asn Ala Val Leu Arg Leu 25 Ser Arg Gly Glu Ile Glu Asp Val Phe Val Gly Glu Cys Phe Asn Ser 40 Asp Lys Gin Lys Tyr Trp Arg Ile Leu Glu Asp Lys Thr Ala His Phe 55 Ile Glu Ala Ser Leu Lys Ser Met Ala Ile Leu Leu Asn Lys Asp Ala 70 75 Lys Met Tyr Ala Asp Phe Gly Leu His Phe Gly Met Ala Phe Gin Ile se* 85 90 Ile Asp Asp Leu Leu Asp Ile Thr Gin Asp Ala Asn Thr Leu Gly Lys 100 105 110 Pro Asn Phe Ser Asp Phe Lys Glu Gly Lys Thr Thr Leu Pro Tyr Leu 115 120 125 Leu Leu Tyr Glu Lys Leu Asn Gin His Glu Gin Gly Leu Leu Ile Ser 130 135 140 Tyr Phe Lys Gin Asp Ser His Glu Ile Ile Glu Trp Thr Lys Giu Lys 145 ISO 155 160 Phe Lys Gin His Gly Ile Ile Glu Glu Thr Leu Lys Ile Ala Gin Val 165 170 175 Tyr Ser Lys Lys Ala Leu Glu Ala Ile Lys Gly Glu Asn Asn Leu Ile 180 185 190 Leu Glu Lys Leu Ala Gin Asp Val Ile Tyr Arg.Thr Phe 195 200 205 *to INFORMATION FOR SEQ ID NO:1494: SEQUENCE CHARACTERISTICS: LENGTH: 131 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...131 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1494 Lys Lys Val Lys Met Asn Ile Lys Ile Leu Lys Ile Leu Val Gly Gly 1 5 10 Leu Phe Phe Leu Ser Leu Asn Ala His Leu Trp Gly Lys Gin Asp Asn 1056 25 Ser Phe Leu Gly Ile Gly Glu Arg Ala Tyr Lys Ser Gly Asn Tyr Ser 40 Lys Ala Ala Ser Tyr Phe Lys Lys Ala Cys Asn Asp Gly Val Ser Glu 55 Gly Cys Thr Gin Leu Gly Ile Ile Tyr Glu Asn Gly Gin Gly Thr Arg 70 75 Ile Asp Tyr Lys Lys Ala Leu Glu Tyr Tyr Lys Thr Ala Cys Gin Ala 90 Asp Asp Arg Glu Gly Cys Phe Gly Leu Gly Gly Leu Tyr Asp Glu Gly 100 105 110 Leu Gly Thr Ala Gin Asn Tyr Gin Glu Ala Ile Asp Ala Tyr Ala Arg 115 120 125 His Ala Phe 130 INFORMATION FOR SEQ ID NO:1495: SEQUENCE
CHARACTERISTICS:
LENGTH: 239 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...239 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1495 Ser Ser Lys Thr Ala Phe Arg Ala Lys Gln Ile Ile Thr Ala Thr Asp 1 5 10 Ile Ser Ala Gin Lys Arg Gin Glu Arg Leu Ala Ser Met Gly Lys Ile 25 Ser Ala His Leu Ala His Glu Ile Arg Asn Pro Val Gly Ser Ile Ser 40 Leu Leu Ala Ser Val Leu Leu Lys His Ala Asn Glu Lys Thr Lys Pro 55 Ile Val Val Glu Leu Gin Lys Ala Leu Trp Arg Val Glu Arg Ile Ile 70 75 Lys Ala Thr Leu Leu Phe Ser Lys Gly Ile Gin Ala Asn Arg Thr Lys 90 Gin Ser Leu Lys Thr Leu Glu Ser Asp Leu Lys Glu Ala Leu Asn Cys 100 105 110 Tyr Thr Tyr Ser Lys Asp Ile Asp Phe Leu Phe Asn Phe Sen Asp Glu 115 120 125 Glu Gly Phe Phe Asp Phe Asp Leu Met Gly Ile Val Leu Gin Asn Phe 130 135 140 Leu Tyr Asn Ala Ile Asp Ala Ile Glu Ala Leu Glu Glu Ser Glu Gin 145 150 155 160 Gly Gin Val Lys Ile Glu Ala Phe Ile Gin Asn Glu Phe Ile Val Phe 165 170 175 Thr Ile Ile Asp Asn Gly Lys Glu Val Glu Asn Lys Ser Ala Leu Phe 180 185 190 Glu Pro Phe Giu Thr Thr Lys Leu Lys Gly Asn Gly Leu Gly Leu Ala 195 200 205 Leu Sen Leu Gin Val Val Lys Ala His Glu Gly Ser Ile Ala Leu Leu 210 215 220 1057 Giu Asn Gin Glu Lys Thr Phe Glu Ile Lys Ile Leu Asn Ala Ser 225 230 235 INFORMATION FOR SEQ ID NO:1496: SEQUENCE CHARACTERISTICS: LENGTH: 155 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .155 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1496 Lys Pro Lys Thr Ile Leu Lys Lys Gly Leu Leu Met Lys Thr Phe Giu 1 5 10 1s Ile Leu Lys His Leu Gin Ala Asp Ala Ile Val Leu Phe Met Lys Val 25 His .Asn Phe His Trp Asn Val Lys Giy Thr Asp Phe Phe Asn Val His 40 Lys Ala Thr Glu Giu Ile Tyr Giu Gly Phe Ala Asp Met Phe Asp Asp 55 Leu Ala Glu Arg Ile Val Gin Leu Gly His His Pro Leu Val Thr Leu 6570 75 Ser Giu Ala Ile Lys Leu Thr Arg Val Lys Giu Giu Thr Lys Thr Ser 90 Phe His Ser Lys Asp Ile Phe Lys Glu Ile Leu Giu Asp Tyr Lys His *100 105 110 Leu Glu Lys Glu Phe Lys Glu Leu Ser Asn Thr Ala Giu Lys Giu Gly ~**115 120 125 Asp Lys Val Thr Vai Thr Tyr Ala Asp Asp Gin Leu Ala Lys Leu Gin 130 135 140 Lys Se Ile Trp Met Leu Giu Ala His Leu Ala 145 ISO 155 INFORMATION FOR SEQ ID NO:1497: SEQUENCE CHARACTERISTICS: LENGTH: 131 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOT HET ICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE NAME/KEY: misc-feature LOCATION .131 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1497 1058 Gly Ile 1 Ala Ser Ser Lys Leu Leu Leu Cys Asp Val Ala Leu Ser Lys Ala Pro 130 Cys Trp Ile Asp Ala Ile Phe Ala 115 Leu Met Ile Gly Glu Ile Asp Gly 100 Phe Giu Giu Ser Thr Giu 70 Ala Phe Glu Arg Glu Met 40 Ala Ile Met Ala Ser 120 Leu Ser 25 Leu Ile Gin Arg Val1 105 Lys Lys 10 Gly Arg Leu Thr Arg 90 Met Met Ala Phe Ser Leu Ala 75 Lys Leu Gly Ile Ile Lys Asp Ser Leu Gly Giu Gin Asp Leu Lys Leu Pro Asp Ser 125 Asn Ala Met Ala Leu Ser Val 110 Ile Lys is Leu Leu Leu His Ile Phe Ala Ile Phe Ala Asn Asp Asn Tyr Gin 4.
4 4* 4 4. .4 4 4 4* 4* 4 4.
9 INFORMATION FOR SEQ ID NO:1498: SEQUENCE
CHARACTERISTICS:
LENGTH: 577 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (Vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: Misc-feature LOCATION 1 S577 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1498 .4 4 44* 4 Cys 1 Lys Pro
LYS
His Trp Phe Glu Leu Arg 145 Gly Asp Leu Val Gly Glu Lys Asn Pro 130 Pro Ala Gin 35 Leu Ala Lys Asp Ile 115 Val1 Arg Sen Val1 Ile Asp Gin Sen Arg 100 Thr His Phe Phe Sen 180 5 Leu Gly Lys Asn Gly Lys Glu Leu ly His 165 Sen Gly Glu 55 Leu Leu Asn Ala Gin 135 Val1 Asp Pro Ile 40 Asn Met Asp Asp Ala 120 Ile Arg Ala Lys 25 T~yr Val Her Lys Phe 105 As n His Ala Glu Ile 185 10 His Asn Thr Phe Tyr 90 Val1 Phe Thr Arg Her Pro Phe His Val 75 Gly Leu Ile Lys Giu 155 Leu Gly Leu Lys 60 Val1 Lys Ser Lys Phe 140 Phe Asp Asn Pro Ang Leu Glu Pro Her 125 Arg Ile Lys Gly Leu Met Ala Leu Thr 110 Tyr Asp Met Glu Gly 190 Met Leu Phe Ser Lys Leu Phe Ala Pro Thr Leu Lys (G1in Pro Pro Gly His Ala Lys Gin Giu Her Leu Leu Val Leu Giu Lys Gin Glu Ile Lys Asp 160 Ile Leu 175 Leu Asp Asn Thr Gin Ala Tyr Lys Glu Leu Her Asp Leu 1059 Ile Gly Phe Arg Ile Val Giu Ala Asp Ser Giy Ala 195 Iff Gly Ser Lys Ser 205 Arg Cys 225 Lys Thr Glu Asp Giu 305 Leu Ile Glu 210 Gin Arg Pro Pro Lys 290 Glu Glu Ala Phe Asn Thr Asn Tyr 275 Glu Thr Leu Gly Ile Ile Phe a a a.
a Ala Glu 385 Cys Gly Ser Tyr Ser 465 Val Ala Leu Leu Ser 545 Ile Glu Asn 370 Asn Pro His Phe Gly 450 Asp Val Phe Asp Ile 530 Lys Lys 355 Glu Leu Asn Ile Leu 435 Ile Asp Ile Glu Asp 515 Gly Glu Asp 1
I
Vai Val Cys Asp Glu Pro 245 Thr Thr 260 Phe Vai Thr Leu Lys Ala Arg Glu 325 Phe Ile 340 Asp Glu Lys Asp Val Tyr Cys Gin 405 Phe Lys 420 Asp Lys Gly Ile Leu Gly IVal Val 485 Val Tyr 500 krg Asp 1lu Arg ?he Glu LeL Tyz 230 Leu Ser Leu Ala Leu 310 Ala Gly Asp Phe Ala 390 Gly Leu Asn Ser Cys 470 Ser Glu la Leu :ys 2 Th2 215 Ala Met Ala Lys Cys 295 Asn Asn Pro Leu His 375 Asp Ala Gly Gly Arg 455 Val Asn Arg Arg Ala 535 Ile Glu Ala Ser Pro Ala 280 Phe Thr Glu Tyr Lys 360 Ala Ile a Leu Gin Lys 440 Leu I Trp A Leu I Leu I Phe C 520 Leu I Lys A Cy As, Pr Se2 26E Let Phc LeL Glu Gly 345 Glu Va1 Val Lys Ser 425 lu .eu rhr *ys .eu i05 ;ly :le irg s Gly Glu Asp 220 Ile Glu Ile 235 Ser Ala Leu 250 r Val Ala Glu Val Asn Lys Val Arg Gly 300 Asn Leu Leu 315 Asp Leu Asn 330 -Leu Lys Lys Gly Asp Cys Gly Val Asp 380 Gin Val Lys 395 Tyr His Lys 410 Tyr Ala Lys Arg Phe Phe Ser Val Ile I 460 Lys Asn Thr 475 Asp Glu Ala C 490 Gin Lys Gly N, Ala Lys Met p 5 Val Gly Lys G 540 Ala Asn Leu G 555 Ile Leu Giu M 570 Thi Ala Ala Phe Va1 285 Asp Gly Lys His Leu 365 Leu Glu Ser 3er ;lu 145 jeu la ;ln al.
Lrg ;ln lu :et Ii Ly: Ly Phe 27 Il Asr Ala Ala Va1 350 Ile Lys Ser Leu Leu 430 Met Glu Pro Lys Asp 510 Asp Thr Lys Leu e Val Arg Phe 255 a Lys s His Asn Asn Gly 335 Cys Val Gly Asp Glu 415 Lys dly Gin Phe Lys I 495 Ala I Phe C Leu C Gin *J Ala S 575 Val Ser 240 Pro Thr Lys Leu Ala 320 Leu Tyr Gly Phe Cys 400 Va1 Ala Cys Lys Asp 480 'eu eu ;lu ;lu 7hr er 550 Ile Glu Leu Glu Glu Lys INFORMATION FOR SEQ-ID NO:1499: i) SEQUENCE CHARACTERISTICS: LENGTH: 184 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) (vi) HYPOTHETICAL:
YES
ORIGINAL SOURCE: ORGANISM: Helicobacter pylori 1060 (ix) FEATURE:: NAME/KEY: misc-feature LOCATION 1. 184 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1499 Ile Arg Glu Pro Gln Val Ala Ile Met Thr Ala Met Met Arg Tyr Phe 1 5 10 His Ile Tyr Ala Thr Thr Phe Phe Phe Pro Leu Ala Leu Leu Phe Ala 25 Val Ser Gly Leu Ser Leu Leu Phe Lys Ala Arg Gin Asp Thr dly Ala 40 Lys Ile Lys Glu Trp Val Leu Glu Lys Ser Leu Lys Lys Giu Glu Arg 55 Leu Asp Phe Leu Lys Gly Phe Ile Lys Glu Asn His Ile Ala Met Pro 70 75 Lys Lys Ile Glu Pro Arg Glu Tyr Arg Gly Ala Leu Val Ile Gly Thr 90 Pro Leu Tyr Glu Ile Asn Leu Glu Thr Lys Gly Thr Gin Thr Lys Ile 100 105 110 Lys Thr Ile Glu Arg Gly Phe Leu Gly Ala Leu Ile Met Leu His Lys 115 120 125 Ala Lys Val Gly Ile Val Phe Gin Ala Leu Leu Gly Ile Phe Cys Val 130 135 140 Phe Leu Leu Leu Phe Tyr Leu Ser Ala Phe Leu Met Val Ala Phe Lys 145 150 155 160 Asp Thr Lys Arg Met Phe Ile Ser Val Leu Ile Gly Ser Val Val Phe Phe Gly Ala Ile Tyr Trp Ser Leu 180 a INFORMATION FOR SEQ ID NO:i500: SEQUENCE CHARACTERISTICS: LENGTH: 90 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAM~E/KEY: misc-feature LOCATION (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1500 Leu Ile Lys Ser Lys Ser Lys Lys Trp Leu Leu Val Gly Giu Giy Ala 1 5 10 Asn Ser Gu Ile Phe Giu Ala Ser Met Gin Sen Leu Leu Lys Thr Asp 25 Gly Val Tyr Sen Asn His Lys Pro Ile Tyr Gin Glu Phe Tyr Giu Leu 40 Asn Ser His Asn-Gly Leu Tyr Tyr Gin Pro Asn Val Phe Phe Ala Tyr s0 55 Glu Ser Cys Ala Leu Gly Phe Arg Lys Giy Gly Leu Ile Leu Asp Asn 70 75 Phe Sen Lys Phe Val Ser His Arg Leu Gin 190 1061 INFORMATION FOR SEQ ID NO:1501: SEQUENCE CHARACTERISTICS: LENGTH: 283 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1..-283 (xi) SEQUENCE DESCRIPTION: SEQ ID a a. a a a a a Met Lys Arg Lys Asp 65 Ser Arg Leu Asn Ile 145 Leu Val His Glu Ser 225 Thi-r Lys Ser Asn Val Gin Gly Ser Ile Gly Asn Sen Asn Giu Val Lys Asn 115 Lys Val 130 G1 n Ile Val Gin Asp Giu Pro Ile 195 Pro Leu 210 Leu Asp Ile Ala Gly Met Ala Lys 275 Ala Asp Gin Ile Leu Ser 100 Pro Phe Thr Giu Lys 180 Val Asn Thr Gly Val 260 Ti-p Ala Lys Gly Tyr Leu 85 Asn Gly Arg Ile 165 Ser Val Asp Ala Val 245 Ser Arg Val1 Ile Gly Ala 70 Ser Asp Phe Asn Pro 150 Pro Gly Thi- Ser His 230 Val1 Ile Met Asp Th- 55 Leu Ala Leu
LYS
Lys 135 Giu Ile Thr Ser Lys 215 Asn Lys Leu Tyr Ile Ile 40 Leu Ala Asn Phe Asn 120 Val Arg Ile Gin 200 Asn Thr Ala Gin Asp 280 Thr 25 His Val Gin Ile His 10s Ala Ala Leu Val 185 Asp Met Leu Leu Ala 265 Lys Ala Ile Met Gly Ile 90 Lys Ile Ile Ser Arg 170 Ser Ile Gin Ser Gin 250 Leu Gin Ser Ser Thr Ala 75 Asn Asn Gin Ala Met 155 Ala Gly Thr Asp Ser 235 Lys Lys Gin Leu Ser Pro Ile Gly Ala Val Leu 140 Val Lys Val Leu Leu 220 Asn Ile Lys Leu Giu Sen Val Asn Val Lys Ile Ser Ala Asn Asp Ile Pro Pro Ile Gly Leu Asn Ile Sen Ala Thr Met Th- 110 Gin Asn 125 Asp Pro Giu Phe Asn Lys Asp Ile 190 Lys Ile 205 Asp Asn Gly Lys Gly Val Ser Gly 270 Lys Phe Asp Ala Gly Ile Leu Thr Lys Leu Ile 175 Ile Thr Asn Asn Sen 255 Ala Ser Ala Ala Val Asn Glu Ser Leu Thr Ala 160 Ile Val Lys Met Ile 240 Ala Ile INFORMATION FOR.SEQ ID NO:i502: SEQUENCE CHARACTERISTICS: LENGTH: 222 amino acids TYPE: amino acid 1062 TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .222 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1502 a.
a a Thr Phe Ile Leu Thr Gin Trp Asp Leu Met 145 Lys Lys Giu Ala Ile Ser Leu s0 Phe Glu Asp Phe Ser 130 Ile Gin Asn Asn Ile 210 Ala Ala Leu Val1 Gin Asn Phe 115 Gin Asn Gin Gin Thr 195 Ala Leu Phe Leu Ala Ile Pro 100 Arg Lys Leu Leu Gin 180 Leu Lys Ala Arg Leu 55 Leu Leu Ser Leu 135 Gin Asn Giu Ala Ile 215 Trp Gly 40 Gly Ser Asp Leu Thr 120 Asn Lys Leu Leu Asn 200 Leu Giu Arg Ile Arg Lys Asp Gin Lys 75 Glu Lys Asn Asn Gin Asn Lys Leu 140 Leu Giu 155 Asn Gly Thr Ala Ser Ser Gin Leu 220 Gly His Gly Arg Leu Gly Trp Ile Leu Asn Pro Lys Met Leu Leu Ile Val1 Ala Met 125 Thr Leu Ile Ile Pro 205 Giu Lys Leu Leu Giu Gin Val Asn 110 Ser Gin Lys Giu Lys 190 Asp Ile Ala Ser Thr Ile Ala Ser Val Leu Ser Lys Asn 175 As n Leu Lys Phe Ala Gin Leu Lys Ser Gly Lys Thr 160 Tyr Leu Ile
INFORMATION
FOR SEQ ID NO:1S03: SEQUENCE CHARACTERISTICS: LENGTH: 347 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .347 (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1S03 1063 Ile Val Phe His Gin Gly Ser Leu Ser Val Ser Gly Leu Phe Lys Met 1 5 10 Arg Ile Leu Ser Phe Lys Lys Asn Lys Arg Ala Val Phe Ser Leu Tyr 25 Leu Phe Ile Ala Leu Leu Ala Leu Ser Leu Leu Ala Pro Leu Trp Val 40 Asn Asp Arg Pro Leu Phe Ile Tyr Lys Asp Asn Lys Ala Tyr Phe Pro 55 Met Phe Lys Asn Tyr Ala Glu Val Glu Phe Gly Gly Asp Phe Phe Thr 70 75 Pro Thr Asp Tyr Asn Asp Pro Tyr Val Gin Asn Thr Leu Leu Lys Asp 90 Ala Phe Ile Ile His Ala Leu Ile Pro Tyr Ser Tyr Asp Thr Ile Ile 100 105 110 Met Asp Leu Asp Ser Pro Ala Pro Thr Pro Pro Ser Phe Lys His Leu 115 120 125 Leu Gly Thr Asp Asp Gin Ala Arg Asp Val Leu Ala Arg Leu Val Tyr 130 135 140 Gly Tyr Arg Val Ser Leu Val Phe Gly Ile Leu Leu Thr Leu Phe Ser 145 150 155 160 Val Leu Ile Gly Val Ser Leu Gly Ala Phe Gin Gly Tyr Tyr Gly Gly 165 170 175 Leu Val Asp Leu Val Gly Gin Arg Leu Ser Glu Ile Trp Ser Ala Ile 180 185 190 Pro Met Leu Phe Leu Leu Ile Val Ile Ser Ser Ala Phe Asn Ser Asn 195 200 205 Phe Trp Ile Ile Leu Phe Leu Val Leu Leu Phe Ser Trp Met Gly Leu oe 210 215 220 Ser Gin Val Val Arg Thr Glu Phe Leu Lys Ala Arg Asn Met Asp Tyr 225 230 235 240 Thr Lys Ala Ala Arg Ala Leu Gly Val Asn Asp Leu Lys Ile Ile Phe H 245 250 255 STyr His Val Leu Pro Asn Ala Leu Val Ala Thr Ile Thr Tyr Ile Pro S260 265 270 Phe Leu Met Ala Ala Ser Ile Ser Thr Leu Val Ser Leu Asp Phe Leu 275 280 285 Gly Phe Gly Met Pro Ile Gly Ser Ala Ser Leu Gly Glu Leu Val Asn 290 295 300 Gn Gly Lys Asp Asn Leu Thr Thr Pro His Leu Ala Val Val Ala Phe 305 310 315 320 Val Ala Ile Ser Leu Leu Leu Ser Val Leu Val Phe Ile Gly Glu Gly 325 330 335 Val Arg Asp Ala Phe Asn Ala Asn Met Leu Lys 340 345 i: INFORMATION FOR SEQ ID NO:1504: SEQUENCE CHARACTERISTICS: LENGTH: 519 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...519 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1504 1064 Arg Gly Tr 1 His Phe Ser Va1 Leu Leu His Ser Phe Leu Tyr 145 Met Thr Gin Al Va Ph~ Le Le Le As 13 Pr Gi' Al Let
S
Leu Lys 21C Gly Glu 225 Lys His Lys Asn Ser Val Pro Leu 290 Gly Ile 305 Leu Leu Ser Val Leu Gin Ser Ile 370 Ala Ser 385 Vai Cys -a Ile Li Met e Glu u Arg u Asn u His 115 n Ala 0 0 Tyr r Ile x Leu 1 Ser 195 Ala I ile Glu Leu Tyr 275 Ile Ile Lys Gly I Met 1 355 Gin I Gin C Leu A Glu 4 lie I 435 Lys S Ser T Asp A *Met Leu Giu Ile Lys 5 Leu Gin Asn Ile Asn Vai Gly Giu Ser Gly 40 Arg Leu Asn Pro Arg 55 Thr Thr Asn Leu Leu 70 Gly Asn Ile Ile Ala Pro Leu His Lys Ile 100 His Lys Asn Ala Ser 120 Met Lys Gin Vai Gin 135 Glu Leu Ser Gly Gly 150 Ile Asn Ala Pro Lys 165 Asp Ala Gin Ile Gin 180 Val Giu Lys Asn Ile 200 Val Lys Arg Leu Ala 215 Val Giu Thr Asn Leu 230 Tyr Ser Lys Leu Leu 245 Lys Ala Leu Asp Glu 260 lyr Leu Gin Lys Arg I 280 Ala Ser Val Asp Phe S 295 Uy Giu Ser Gly Ser G 310 eu Ala Leu Asn Ser G 325 .eu Leu Asn Ser Lys A 340 3 lal Phe Gin Asp Pro 360 er Ile Leu Ile Giu A 375 ;In Giu Trp His His L 390 Lsn Pro Giu Leu Leu A 405 rg Gin Arg Val Ala I 20 4 le Leu Leu Asp Giu P: 440 er Val Leu Giu Leu L 455 yr Leu Phe Ile Ser H 470 rg Val Leu Val Val SE Il 25 Se Ph Ly
TY
GI
10
G;
Le
GI,
Lei As 18S Alz Asr rhr Ile Chr 65 ?he jer ly :ly la 45 Yr la eu sn le 25 ro eu is r nn 55 ;n L .e Si r d e L s G1 r 12 90 y L' 5 Va As Ar 1 Le 17 i Gi Le Arc Ly 25( Let Phe Leu Lys Glu 330 Phe Ala Leu Ala Phe 410 Ala Thr Leu Asp Glu 490 Pro eu Asn 0 er Leu Ly Lys rs Pro .u Ser 75 .e Ala s Gin .1 Leu p Glu g Gin 155 u Ile 0 Ile Leu g Val s diu I 235 i Ala Leu C Arg I Lys 3 Ser S 315, Glu L Lys P Ser L Arg P 3 Glu L 395 Tyr A Arg A Ser A: Asn Li 4L Leu A 475 Giy L) Lys Hi
C
SE
Se Hi Gi Gi Me Le Ly 141 Arc Cy Let Phe Tyr 220 Leu 3er lu r o la *00 er ys ro eu he 80 eu la la La ss ss 's V ~r 'I r S 4' s As u A n As t Se Ly 12 s Ph g Va 3 As 1 As 20! Va Phi As Va Sez 285 Lys Leu Ile Tyr Asn 365 Ala Cys Tyr Ile Leu 445 Gin Val Ile Ala al Leu Asn yr Ser Glu er Ile Ala sn Gly Glu La Phe Met ;p Pro Leu r Giu Ala 110 Glu Gin .e Leu Asp 1 Cys Ile p Giu Pro 175 p Leu Leu 190 e Ser His
S
1 Leu Lys I e Asn Asp I i Leu Pro I 255 L Lys Asp 1 270 Leu Lys I Gu Asn I Ala Leu G 3 Leu Gly G 335 Arg Lys I 350 Pro Arg L Tyr Pro L Leu Giu G 4( Glu Leu Si 415 Ala Leu L2 430 Asp Lys SE Glu Lys GJ Ile Lys Al 48 Val Giu Th 495 Tyr Thr Ly 510 Ser Arg Asn Ile Gin Ser Tyr Val Arg Ala 160 Thr Lys Asp Lys ?ro 240 Ua )he 'ys :le ly in le eu ys lu e5 s rr nn aa I0 r Gly Pro Ile Asp 465 Phe Gly Arg Gin 450 Leu Cys Gly Ala Ile Glu 500 485 Glu Val Phe Asp Sc 1065 Arg Leu Leu Glu Ser Arg Leu 515 INFORMATION FOR SEQ ID NO:1505: SEQUENCE CHARACTERISTICS: LENGTH: 183 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...183 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1505 Gly Gly Leu Met Asn Thr Ile Ile Arg Tyr Ala Ser Leu Trp Gly Leu 1 5 10 Cys Ile Thr Leu Thr Leu Ala Gin Thr Pro Ser Lys Thr Pro Asp Glu 20 25 Ile Lys Gin Ile Leu Asn Asn Tyr Ser His Lys Asn Leu Lys Leu Ile 35 40 Asp Pro Pro Thr Ser Ser Leu Glu Ala Thr Pro Gly Phe Leu Pro Ser 50 55 Pro Lys Glu Thr Ala Thr Thr Ile Asn Gin Glu Ile Ala Lys Tyr His 65 70 75 Glu Lys Ser Asp Lys Ala Ala Leu Gly Leu Tyr Glu Leu Leu Lys Gly 90 Ala Thr Thr Asn Leu Ser Leu Gin Ala Gin Glu Leu Ser Val Lys Gin 100 105 110 Ala Met Lys Asn His Thr Ile Ala Lys Ala Met Phe Leu Pro Thr Leu 115 120 125 Asn Ala Ser Tyr Asn Phe Lys Asn Glu Ala Arg Asp Thr Pro Glu Tyr 130 135 140 Lys His Tyr Asn Thr Gln Gin Leu Gin Ala Gin Val Thr Leu Asn Val S 145 150 155 160 Phe Asn Gly Phe Ser Asn Val Asn Asn Val Lys Glu Lys Ser Ala Thr 165 170 175 S* Thr Asp Pro Leu Trp Leu Ile 180 INFORMATION FOR SEQ ID NO:1506: SEQUENCE CHARACTERISTICS: LENGTH: 229 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: 1066 NAME/KEY: misc-feature LOCATION .229 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1S06 Val Lys Phe Ser Val Leu Thr Leu Phe Pro Gin Leu Asp Val His Ile Leu Ala Asp Asp Ser Glu Asn Giu 195 Leu His Ser Leu Thr Giu Ser Gin 100 Glu Phe Ile Asn Ala 180 Tyr Ser Lys Ile Asn Leu Asn Ala Lys Arg Ile Ala Giu 165 Val Ser Lys Ser Leu Leu Ile Aia Vali Lys Ser Leu Arg iso Se r Phe Lys Leu Lys Asn Gin Asn Gin Cys Asp Gly 140 Leu Leu Asn Ile Arg 220 Ile Asn Lys Ile Pro Ile Gly Giu 125 Ala G ly Giu Lys Lys 205 Leu V V
V
V V V.e
V.
V V INFORMATION FOR SEQ ID NO:1507: SEQUENCE CHARACTERISTICS: LENGTH: 366 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE:.- NAME/KEY: misc-feature LOCATION .366 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1507 Arg Giu Gin Trp Phe His Phe Arg Ser Thr Pro Pro Thr Vai Val Leu 10 1s Met Ala Gly Leu Gin Gly Ser Gly Lys Thr Thr Thr Thr Ala Lys Leu 25 Ala His Tyr Leu Lys Thr Lys Asn Lys Lys Val Leu Leu Cys Ala Cys 40 Asp Leu Gin Arg Leu Ala Ala Val Giu GIn Leu Lys Val Leu Gly Giu 55 1067 Gin Val Gly Val Glu Val Phe His Glu Glu Asn Lys Ser Val Lys Glu 70 75 Ile Ala Asn Asn Ala Leu Lys Arg Ala Lys Glu Ala Gln Phe Asp Val 90 Leu Ile Val Asp Ser Ala Gly Arg Leu Ala Ile Asp Lys Glu Leu Met 100 105 110 Gin Glu Leu Lys Glu Val Lys Glu Val Leu Asn Pro His Glu Val Leu 115 120 125 Tyr Val Ala Asp Ala Leu Ser Gly Gin Asp Gly Val Lys-Ser Ala Asn 130 135 140 Thr Phe Asn Glu Glu Ile Gly Val Ser Gly Val Val Leu Ser Lys Phe 145 150 155 160 Asp Ser Asp Ser Lys Gly Gly Ile Ala Leu Gly Ile Thr Tyr Gin Leu 165 170 175 Gly Leu Pro Leu Arg Phe Ile Gly Ser Gly Glu Lys Ile Pro Asp Leu 180 185 190 Asp Val Phe Met Pro Glu Arg Ile Val Gly Arg Leu Met Gly Ala Gly 195 200 205 Asp Ile Ile Ser Leu Ala Glu Lys Thr Ala Ser Val Leu Asn Pro Asn 210 215 220 Glu Ala Lys Asp Leu Ser Lys Lys Leu Lys Lys Gly Gin Phe Thr Phe 225 230 235 240 Asn Asp Phe Leu Asn Gin Ile Glu Lys Val Lys Lys Leu Gly Ser Met 245 250 255 Ser Ser Leu Ile Ser Met Ile Pro Gly Leu Gly Asn Met Ala Ser Ala 260 265 270 Leu Lys Asp Thr Asp Leu Glu Ser Ser Leu Glu Val Lys Lys Ile Lys 275 280 285 Ala Met Val Asn Ser Met Thr Lys Lys Glu Arg Glu Asn Pro Glu lie 290 295 300 Leu Asn Gly Ser Arg Arg Lys Arg Ile Ala Leu Gly Ser Gly Leu Glu 305 310 315 320 "*Val Ser Glu Ile Asn Arg Ile Ile Lys Arg Phe Asp Gin Ala Ser Lys 325 330 335 SMet Ala Lys Arg Leu Thr Asn Lys Lys Gly Ile Ser Asp Leu Met Asn 340 345 350 Leu Met Ser Gin Ala Lys Asn Gin Thr Pro Pro Lys Met Arg 355 360 365 INFORMATION FOR SEQ ID NO:1508: SEQUENCE CHARACTERISTICS: LENGTH: 270 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...270 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1508 Arg Lys Ala Met Asn Thr His Leu Lys Gin Leu Ile Glu Ile Ser His 1 5 10 Leu Asp Lys Glu Ile Asp Ser Leu Glu Pro Leu Ile Arg Glu Lys Arg 25 Lys Asp Leu Asp Lys Ala Leu Asn Asp Lys Glu Ala Lys Asn Lys Ala 1068 40 Ile Leu Asn Leu Giu Giu Giu Lys Leu Ala Leu Lys Leu Gin Vai Ser 55 Lys Asn Giu Gin Thr Leu Gin Asp Thr Asn Ala Lys Ile Ala Ser Ile 70 75 Gin Lys Lys Met Ser Glu Ile Lys Ser Giu Arg Giu Leu Arg Ser Leu 90 Asn Ile Glu Giu Asp Ile Ala Lys Glu Arg Ser Asn Gin Ala Asn Arg 100 105 110 Glu Ile Giu Asn Leu Gin Asn Giu Ile Lys His Lys Ser Giu Lys Gin 115 120 125 Giu Val Leu Lys Lys Giu Met Leu Giu Leu Giu Lys Leu Ala Leu Giu 130 135 140 Leu Glu Asn Leu Val Giu Asn Giu Val Lys Asn Ile Lys Giu Thr Gin 145 150 155 160 Gin Ile Ile Phe Lys Lys Lys Giu Giu Leu Val Giu Lys Thr Giu Pro 165 170 175 Lys Ile Tyr Ser Phe Tyr Giu Arg Ile Arg Arg Trp Ala Lys Asn Thr 180 185 190 Ser Ile Val Thr Ile Lys Lys Gin Ala Cys Gly Gly Cys Phe Ile Arg 195 200 205 Leu Asn Asp Lys Ile Tyr Ala Giu Val Leu Thr Ser Gly Asp Met Ile 210 215 220 Thr Cys Pro Tyr Cys Gly Arg Ile Leu Tyr Ala Glu Ser Thr His Glu 225 230 235 240 Ser Asn Ala Gin Pro Pro Lys Giu Ser Gin Pro Lys Giu Ser Gin Giu *245 250 255 Giu Ser Gin Giu Glu Ser Gin Giu Glu Ser Gin Giu Ser Val 260 265 270 *see IN~FORMATION FOR SEQ ID NO:1509: SEQUENCE CHARACTERISTICS: LENGTH: 567 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: too*g ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc..feature CCC LOCATION .567 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1509 Met Asn Giu Ile Asp Lys Ser Vai Asp Ile Gly Phe Leu Arg Ile Leu 1 5 10 Asp Val Ile Lys Lys Val Lys Thr Pro Lys Gly Gly Ile Giu Val Leu 25 Arg Thr Leu Ile Asp Phe Thr Pro Lys Ile Giu Asn Ala Leu Asn Leu 40 Ala Thr Lys Sen His Lys Gly Gin Tyr Ang Lys Ser Gly Giu Pro Tlyr 55 Ile Val His Pro-Ile Cys Val Ala Ser Val Vai Ala Phe Cys Gly Gly 70 75 Asp Giu Ala Met Val Cys Ala Ala Leu Leu His Asp Val Val Giu Asp 90 Thr Pro Cys Giu Ile Giu Thr Ile Glu Arg Giu Phe Gly Gin Asp Val 100 10s 110 1069 Ala Asn Leu Val Asp Ala Leu Thr Lys Ile Glu Leu Gly
A.
A A
A
A Thr 145 Val Leu Tyr Leu Ile 225 Asn Ser Ile Leu Tyr 305 Arg Ile Arg Trp Met 385 Asp Asp Gly Asp Gin 465 Val Lys Thr Phe Thr 545 Glu 130 Phe Val Pro Ala Glu 210 Lys Ala His Tyr Asp 290 Lys Phe His Thr Lys 370 Arg Pro Ile Ala Lys 450 Glu Ile Asn Lys SGlu 530 Asp Asn Arg Lys His Pro 195 Asp Glu Phe Ser Leu 275 Leu Val Lys Thr Phe 355 Tyr Trp Lys Val Ile 435 Ala Leu Pro His Ser 515 Asp Cys Leu Val Lys Ile Asp 180 Ile Lys Tyr Ala Asp 260 Lys Leu Leu Asp Thr 340 Asp Lys Leu Glu Val 420 Ala Thr Arg Arg Leu 500 Met Ala Gly Gly Ser Ile Ser 165 Lys Ala Ser Leu Ser 245 Phe Met Ala Gly Tyr 325 Ile Met Ala Gln Phe 405 Phe Leu Asp Ser Phe 485 Arg Ile Asp SVal Gin 565 Ser Leu 150 Asp Gln Ser Phe His 230 Lys Lys Gin Ile Ile 310 Ile Phe His Gly Asn 390 Tyr Ser Asp Ala Gly 470 Ile Ile Asn Leu Glu 550 Thr Gin 135 Ile Arg Val Arg Tyr 215 Lys Leu Leu Arg Arg 295 Ile Ala Asp Met Gly 375 Phe Glu Pro Phe Tyr 455 Asp Trp Gin lie Lys 535 Thr His 120 Asp Ser Leu Arg Leu 200 Tyr Asn Glu Val Lys 280 Ile His Leu Glu Gly 360 Val Lys Leu His Ala 440 Ile Val Met Arg Leu 520 Asp Thr Pro Ala His Ile 185 Gly Ile Lys Lys Thr 265 Gly Leu Leu Pro Ser 345 Ala Asp Tyr Ala Gly 425 Tyr Asn Val Asp Arg 505 Ser Tyr Leu Arg Ile Asn 170 Ser Met Tyr Gln Lys 250 Arg Ala Leu Asn Lys 330 Ser Glu His His Lys 410 Asp Met Ser Lys Gin 490 Asn Thr Lys Thr Thr Glu Ile 125 Met Val Val 140 Gin Asp Pro 155 Met Leu Thr Lys Glu Thr Ser Ser Ile 205 Pro Glu Glu 220 Ser Leu Leu 235 Leu Phe Asp Val Lys Arg Val Asn Ile 285 Lys Asn Pro 300 Phe Lys Pro 315 Glu Asn Gly Val Tyr Glu Tyr Gly Asn 365 Glu Glu His 380 Asp Ser Asp 395 Asn Asp Leu Thr Tyr Thr Val His Ser 445 Lys Lys Ala 460 Ile Ile Lys 475 Leu Lys Thr Arg Leu Lys Phe Phe Gly 525 Asn Phe Glu 540 Glu Ala Met Arg Ser Arg Leu Leu 190 Lys Tyr Leu Ser Pro 270 Asp Ile Ile Tyr Val 350 Ser His Leu Tyr Leu 430 Asp Leu Gly Ser Glu 510 Arg Glu Lys Lys Ala Ala Asp 175 Ala Asn Lys Lys Gly 255 Tyr Glu Asp Val Lys 335 Gin Ala Glu Lys Arg 415 Pro Leu Leu Asp Lys 495 Ile Ser Lys Ser Glu Leu Leu 160 Ala Val Glu Asn Leu 240 Phe Ser Ile Cys Ser 320 Thr Ile His Gly Asn 400 Glu Val Gly Asn Lys 480 Ala Asp Val Leu Phe 560 INFORMATION FOR SEQ ID NO:1510: SEQUENCE CHARACTERISTICS: LENGTH: 198 amino acids TYPE: amino acid 1070 TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...198 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1510 Val Thr Ile Lys Ser Phe Ile Asn Gly Leu Arg Arg Asp His Ala Gly 1 5 10 Lys Asp Lys Lys Gin Ala Gly Phe Gly Glu Ile Phe Trp Gly Ser Val 25 Ser Trp Gly Gin Pro Val Trp Ile Asp Ile His Val Leu Asp His Ile 40 Ala Lys Glu Ile Arg Ser Leu Val Glu Asn Asp Ile Glu Val Gly Ile 55 Val Ile Gly Gly Gly Asn Ile Ile Arg Gly Val Ser Ala Ala Gin Gly 70 75 S Gly Ile Ile Arg Arg Thr Ser Gly Asp Tyr Met Gly Met Leu Ala Thr 90 Val Ile Asn Ala Val Ala Met Gin Glu Ala Leu Glu His Ile Gly Leu 100 105 110 Asp Thr Arg Val Gin Ser Ala Ile Glu Ile Lys Glu Ile Cys Glu Ser 115 120 125 Tyr Ile Tyr Arg Lys Ala Ile Arg His Leu Glu Lys Gly Arg Val Val 130 135 140 Ile Phe Gly Ala Gly Thr Gly Asn Pro Phe Phe Thr Thr Asp Thr Ala 145 150 155 160 Ala Thr Leu Arg Ala Ile Glu Ile Gly Ser Asp Leu Ile Ile Lys Ala 165 170 175 Thr Lys Val Asp Gly Ile Tyr Asp Lys Asp Pro Asn Lys Phe Lys Asp 180 185 190 Ala Lys Asn Trp Thr Leu 195 INFORMATION FOR SEQ ID NO:1511: SEQUENCE CHARACTERISTICS: LENGTH: 339 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...339 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1511 Met Asn Ala Leu Lys Arg Ala Cys Leu Arg Leu Met Gly Glu Thr Asn 1 5 10 1071 Thr Asp Asp Leu Ser Pro Ala Ser Asp Ala Phe Thr Arg Ser Asp Ile Pro Leu Gin Arg dly Asp Ile Met Ser Gly Thr Cys Leu Lys 130 Thr Leu 145 Leu Leu Arg Gly Giu Ala Thr Leu 210 Leu Pro 225 Asp Thr Leu Lys Al a Tyr Phe Ile 290 Ile His 305 Gly Gly Gly Ala His Ile Val Trp Gly Giu 115 Glu Asn Asp Leu Phe 195 Ala Gly Thr Phe Pro 275 Thr Thr Asp Gly Al a Glu Val His Ile 100 Asp Gly Asp Giu Thr 180 Lys Gin Ala Gly Asp 260 Lys Gin Trp Ser *Lys Ala Giy Phe Val Ser Asp Lys Val1 165 Asn
LYS
Lys Ala 245 Ala Pro Arg L~eu His 325 Ala le Thr 70 Gly Ile Gly Ile Val 150 Arg Lys Pro Ile Cys 230 Met Pro Ser Gly Asn 310 Thr Met Lys 55 Gly Lys Gly Ala Ile 135 Va 1 Aia Ala Ser Val1 215 Giu Thr Phe Asp Gly 295 Arg Arg Leu 40 Thr Ser Asp Gly Leu 120 Lys Ser Ser Arg Ala 200 Gly Pro Arg Val1 Val1 280 Val Met Phe 25 Lys Lys Ser Ile Val 105 Pro Ile Thr Gly Lys 185 Pro His Lys Asp Leu 265 Ser Ala Gly Pro Asn Gly Arg Pro 90 Ile Ile Phe Arg 170 Phe Lys Ala Val G iu 250 Gin Leu Leu Leu Leu 330 Arg Val1 Lys 75 Phe Ala Val1 Pro Lys 155 Ile Leu Ser Cys Thr 235 Val1 Ser His His Pro 315 Mly Ile Pro Ser Val1 Pro Ala 140 Leu Pro Gly Asp Gly 220 Thr Lys Phe Ala Pro 300 Asp Ile Giu 45 Val1 Ala Pro Ile Asp 125 Lys Giu Leu Leu Ala 205 Val Val1 Glu Cys Thr 285 Gly Thr Ser Asr Ala Thr Asn Phe 110 Val Gly Pro Ile Gly 190 Lys Lys Gly Leu His 270 Leu Asp Leu Phe Tyr Asn Lys Phe Lys Giu G iu Ile 175 Giu G ly Gly Ser Ala Thr Pro Gly Gly Arg 335 Giu Val1 Ser Arg Ala Asp Ile Thr 160 Gly Ser Tyr Ile Gin 240 Ser Ala Gly Val Thr 320 Gln INFORMA~TION FOR SEQ ID NO:i5i2: SEQUENCE CHARACTERISTICS: LENGTH: 154 amrino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc...feature LOCATION .154 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i512 Thr Phe Thr Ile Lys Arg Phe Val Leu Met Lys Ile Lys Ile Gin Lys 1072 1 5 10 1s Ile His Pro Asn Ala Leu Ile Pro Lys Tyr Gin Thr Glu Gly Ser Ser 25 Gly Phe Asp Leu His Ala Val Glu Glu Val Val Ile Lys Pro His Ser 40 Val Gly Leu Val. Arg Ile Gly Ile Cys Leu Ser Leu Glu Val Giy Tyr 55 Giu Leu Gin Val Arg Thr Arg Ser Gly Leu Ala Leu Asn His Gin Val 6S 70 75 Met Val Leu Asn Ser Pro Gly Thr Val Asp Asn Asp Tyr Arg Gly Glu 90 9S Ile Lys Val Ile Leo Ala Asn Leu Set Asp Lys Asp Phe Lys Val Gin 100 105 110 Val. Gly Asp Arg Ile Ala Gin Gly Val Val Gin Lys Thr Tyr Lys Ala 115 120 125 Glu The Ile Glu Cys Glu Gin Leu Asp Giu Thr Ser Arg Gly Ser Giy 130 135 140 Gly Phe Gly Ser Thr Gly Vai Ser Lys Ala 145 150 INFORMATION FOR SEQ ID NO:15i3: SEQUENCE CHARACTERISTICS: LENGTH: 175 amino acids iB) TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc feature LOCATION .175 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1513 Arg Lys Lys Pro Phe Lys Glu Arg Ile Asp Leo Met Asn Lys Pro Phe 1 510 Leu Ile Leu Leo Ile Ala Leu Ile Ala Phe Ser Gly Cys Asn Met Arg 25 Lys Tyr Phe Lys Pro Ala Lys His Gin Ile Lys Gly Giu Ala Tyr Phe 40 Pro Asn His Leu Gin Glu Ser Ile Val Ser Set Asn Arg Tyr Gly Ala 55 Ile Leu Lys Asn Gly Ala Val Ile Gly Asp Lys Gly Leo Thr Gin Leo 70 75 Arg Ile Gly Lys Asn Phe Asn Tyr Giu Sen Sen Phe Leo Asn Giu Set -90 Gin Gly Phe Phe Ile Leo Ala Gin Asp Cys Leu Asn Lys Ile Asp Lys 100 105 110 Lys Thr Ser Lys Ser Arg Ala Ala Lys Thr Gbu Giu Thn Glu Leu Lys 115 120 125 Leu Lys Gly Val Glu Ala Glu Val Gin Asp Lys Val Cys His Gin Val 130 135 140 Glu Le Ile Sen Asn Asn Pro Asn Ala Ser Gin Gin Ser Ile Val Ilie 145 150 155 160 Pro Leu Glu Thr Phe Ala Leu Ala Arg Ala Leo Lys Gly Ile Phe 165 170 175 1073 INFORMATION FOR SEQ ID NO:1514: SEQUENCE CHARACTERISTICS: LENGTH: 219 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...219 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1514 Gly Met Ser Ile Lys Glu Asn Leu Glu Gin Val Arg Asn Glu Phe Lys 1 5 10 Ser Asp Glu Lys Leu Leu Glu Gly Ala Phe Arg Leu Glu Lys Phe Phe 25 Lys Arg Tyr Lys Trp Val Leu Leu Phe Ile Val Val Ala Phe Ile Ala 40 Tyr Leu Gly Asp Thr Lys Leu Gin Asp Tyr Lys His Glu Gin Thr Arg 55 Glu Arg Ile Thr Gin Ile Tyr Asn Glu Val Leu Glu Ser Pro Asn Asn S 65 70 75 Ile Ala Leu Gin Lys Arg Leu Lys Glu Val Ala Pro Glu Leu Tyr Asp 90 Leu Tyr Gin Phe Ala Arg Ala Ser Glu Arg Asn Asp Ala Asn Glu Phe S*1: 00 105 110 Lys Arg Leu Ser Gin Ser Ser Asn Glu Ile Val Lys Ala Phe Ala Lys 115 120 125 Tyr Ser Tyr Ala Ser Leu Ser Arg Asp Lys Asn Leu Leu Glu Lys Ser S130 135 140 Pro Ile Leu Lys Glu Met Ser Ala Leu Gin Glu Val Asn Leu Leu Tyr 145 150 155. 160 Glu Glu Asn Ser Lys Asp Ala Ile Lys Lys Ala His Gin Ser Leu Ser 165 170 175 Thr Ile Pro Leu Ser Ser Ser Leu Tyr Ala Ile Ile Ser Val Leu Lys 180 185 190 His Tyr Gly Met Leu Glu Asp Ile Gin Gin Asn Pro Ser Lys Pro Thr 195 200 205 Asn Leu Lys Lys Glu Thr Ile Gin Gly Thr His 210 215 INFORMATION FOR SEQ ID NO:1515: SEQUENCE CHARACTERISTICS: LENGTH: 198 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: 1074 NAME/KEY: misc_feature LOCATION 1...198 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1515 Lys Arg Tyr Lys Arg Leu Glu Gin Glu Ile Lys Lys Arg Asp Lys Met 1 5 10 Ile Val Gly Leu Ile Gly Val Val Glu Lys Ile Ser Ala Leu Glu Ala 25 His Ile Glu Val Gin Gly Val Val Tyr Gly Val Gin Val Ser Met Arg 40 Thr Ala Ala Leu Leu Gin Thr Gly Gin Lys Ala Arg Leu Lys Ile Leu 55 Gin Val Ile Lys Glu Asp Ala His Leu Leu Tyr Gly Phe Leu Glu Glu 70 75 Ser Glu Lys Ile Leu Phe Glu Arg Leu Leu Lys Ile Asn Gly Val Gly 90 Gly Arg Ile Ala Leu Ala Ile Leu Ser Ser Phe Ser Pro Asn Glu Phe 100 105 110 Glu Asn Ile Ile Ala Thr Lys Glu Val Lys Arg Leu Gin Gin Val Pro 115 120 125 Gly Ile Gly Lys Lys Leu Ala Asp Lys Ile Met Val Asp Leu Ile Gly 130 135 140 Phe Phe Ile Gin Asp Glu Asn Arg Pro Ala Arg Asn Glu Val Phe Leu 145 150 155 160 Ala Leu Glu Ser Leu Gly Phe Lys Ser Ala Glu Ile Asn Pro Val Leu 165 170 175 Lys Thr Leu Lys Pro His Leu Ser Ile Glu Ala Ala Ile Lys Glu Ala 180 185 190 Leu Gin Gln Leu Arg Ser S195 INFORMATION FOR SEQ ID NO:1516: SEQUENCE CHARACTERISTICS: LENGTH: 407 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...407 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1516 Ser Arg Thr Leu Cys Ala Lys Ile Val Leu Gin Lys Glu Arg Lys Lys 1 5 10 Met Glu Ile Gin Gin Thr His Arg Lys Ile Asn Arg Pro Leu Val Ser 25 Leu Val Leu Ala Gly Ala Leu Ile Ser Ala Ile Pro Gin Glu Ser His 40 Ala Ala Phe Phe Thr Thr Val Ile Ile Pro Ala Ile Val Gly Gly Ile 55 Ala Thr Gly Thr Ala Val Gly Thr Val Ser Gly Leu Leu Ser Trp Gly 70 75 Leu Lys Gin Ala Glu Glu Ala Asn Lys Thr Pro Asp Lys Pro Asp Lys 90 1075 Val Trp Arg Ile Gin Ala Gly Lys Phe Asn Glu Phe Pro Asn Glu Trp Trp 145 Leu Gin Ser Lys Ser 225 Ser Gly Val1 Tyr His 305 Ser Leu Ser Gin Gin 385 Lys Asp 130 Asn Ser Lys Tyr As n 210 Gly Giu Ala Trp Ser 290 Leu Asn As n Thr Asn 370 Lys Ala Asp 115 Trp Lys Gly Ala Lys 195 Ile Ala Gly Thr Met 275 Thr Thr Lys Ile Thr 355 Asn Thr Lys Lys Ala Val
ISO
Asn Arg Ala Asp Lys 230 Ser, Leu Leu Thr Asp 310 Ile Pro Ser Asn Glu 390 Leu Ser Ala 135 Asp Phe Leu Asp Asn 215 Ala Ser Ala Gin Ser 295 Gin Giy Pro Gly Thr 375 Pro Ser Leu 120 Arg Met Thr Gly Arg 200 Phe Ser Lys Ser Tyr 280 Lys Asn Thr Glu Thr 360 Giu Thr Gly Gin Lys 160 Met Thr Ala Gly Ala 240 Asp Asn Ser Asn Ala 320 Gly Asn Ser Thr Leu 400 9* 4 .4 *4 *4 INFORMATION FOR SEQ ID NO:1517: SEQUENCE CHARACTERISTICS: LENGTH: 426 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE.
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .426 (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1517 Val Ile Asn Thn Thn Sen Met Leu Lys Lys Ile Phe Leu Thr Asi 'Ser 10 is Leu Gly Ile Leu Cys Sen Arg Ile Phe Gly Phe Leu Arg Asp Leu Met 1076 25 Met Ala Asn Ile Leu Gly Ala Gly Val Tyr Ser Asp Ile Phe Phe Val 40 Ala Phe Lys Leu Pro Asn Leu Phe Arg Arg Ile Phe Ala Glu Gly Ser 55 Phe Ser Gin Ser Phe Leu Pro Ser Phe Ile Arg Ser Ser Ile Lys Gly 70 75 Gly Phe Ala Ser Leu Val Gly Leu Ile Phe Cys Gly Val Leu Phe Met 90 Trp Cys Leu Leu Val Ala Leu Asn Pro Leu Trp Leu Thr Lys Leu Leu 100 105 110 Ala Tyr Gly Phe Asp Glu Glu Thr Leu Lys Leu Cys Thr Pro Ile Val 115 120 125 Ala Ile Asn Phe Trp Tyr Leu Leu Leu Val Phe Ile Thr Thr Phe Leu 130 135 140 Gly Ala Leu Leu Gin Tyr Lys His Ser Phe Phe Ala Ser Ala Tyr Ser 145 150o 155 160 Ala Ser Leu Leu Asn Leu Cys Met Ile Leu Ala Leu Leu Ile Ser Lys 165 170 175 Glu Lys Thr His Leu Glu Ala Leu Tyr Tyr Leu Ser Tyr Gly Val Leu 180 185 190 Leu Gly Gly Val Ala Gin Ile Leu Leu His Phe Tyr Pro Leu Val Lys 195 200 205 Leu Gly Leu Trp Asp Leu Leu Phe Lys Gly Leu Leu Gly Phe Lys Thr 210 215 220 .000, Lys Asn Thr Asn Lys Lys Glu Tyr Arg Leu Asn Arg Ala Lys Lys Asp 225 230 235 240 Leu Lys Ala Phe Phe Lys Gin Phe Phe Pro Ser Val Leu Gly Asn Ser 245 250 255 Ser Ala Gin Ile Ala Ser Phe Leu Asp Thr Thr Ile Ala Ser Phe Leu 260 265 270 Ala Ser Gly Ser Val Ser Tyr Leu Tyr Tyr Ala Asn Arg Val Phe Gin 275 280 285 Leu Pro Leu Ala Leu Phe Ala Ile Ala Ile Ser Thr Ala Leu Phe Pro 290 295 300 Ser Ile Ala Ile Ala Leu Lys Asn Asn Gin Gin Asp Leu Ile Leu Gin 305 310 315 320 Arg Leu Gin Lys Ala Trp Phe Phe Leu Val Gly Val Leu Leu Leu Cys 325 330 335 Ser Ile Gly Gly Ile Met Leu Ser Lys Glu Ile Thr Glu Leu Leu Phe 340 345 350 Glu Arg Gly Gin Phe Ser Pro Lys Asp Thr Leu Ile Thr Ser Gin Val 90355 360 365 Phe Ser Leu Tyr Leu Leu Gly Leu Leu Pro Phe Gly Leu Thr Lys Leu 370 375 380 Phe Ser Leu Trp Leu Tyr Ala Lys Leu Glu Gin Lys Lys Ala Ala Lys 385 390 395 400 Ile Ser Leu Ile Ser Leu Phe Leu Gly Leu Ala Ala Ser Leu Ser Leu 405 410 415 Met Pro Leu Leu Gly Val Leu Gly Leu Arg 420 425 INFORMATION FOR SEQ ID NO:1518: SEQUENCE CHARACTERISTICS: LENGTH: 246 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: 1077 ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .246 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i5i8 Arg Leu Pro Ser Pro Leu Thr Ser Ile Leu Met Phe Ala Leu Pro Asn Asp Ser Val Asn Lys 145 Ser Leu Asn Glu Ile 225 Ile Phe Leu Phe Phe Phe Gly Cys 115 Gin Pro Tyr Leu Lys 195 Phe Glu Phe Asn Lys Ile Val1 Ile Gly 100 Val1 Arg Giu Cys Phe 180 Gly Lys Ser Lys Gin Lys Val Ser Asp Phe Asp Ile Lys Ile 165 Lys Val Asn Leu Arg 245 His Gin Lys Arg 70 Phe Ser Val1 Giu Ile 150 Leu Pro Val His Val 230 Ala Ang Lys Ile Leu 75 Val1 Leu Leu Cys Cys 155 Pro Gly Ala Asp Gly 235 Giu Met Giu Gly Leu Lys Asp Asp 140 Asp Leu Arg Ile Phe 220 Asn Arg Lys Val1 Leu Ala Asp Gly Glu 125 Ile Vai Sen Thr Leu 205 Gin Val1 Leu Ala Val Ile Phe Val Ala 110 Ser Arg Sen Gly Ile 190 Asn Ile Glu Asp Lys Ser Ala Leu Gly Lys Leu Gly Phe Glu 175 Lys Ala Leu Phe Tyr Ala Lys Pro Glu Ala Lys Lys Phe Ile 160 Phe Arg Leu Thr Phe 240 b St S. *k S 5e5S I S S S a t IS 5
S.
S S
S
INFORMATION FOR SEQ ID NO:1519: SEQUENCE CHARACTERISTICS: LENGTH: 849 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .849 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1519 Ang His Val Gin Pro Met Lys Ser Lys Lys Leu Tyr Leu Ala Leu Ile 10 Ile Gly Val Leu Leu Ala Phe Leu Thr Leu Sen Sen Trp Leu Gly Asn 1078 25 Ser Gly Leu Val Gly Arg Phe Gly Val Trp Phe Ala Ala Ile Asn Lys 40 Lys TIyr Phe Gly Tyr Leu Ser Leu Ile Asn Leu Pro Tyr Leu Ala Trp 55 Val Leu Phe Leu Leu Tyr Arg Ala Lys Asn Pro Phe Thr Glu Ile Val 70 75 s0 Leu Glu Lys Thr Leu Gly His Leu Leu Gly Ile Leu Ser Leu Leu Phe 90 Leu Gln Ser Ser Leu Leu Asn Gln Giy Giu Ile Gly Asn Ser Ala Arg 100 105 110 Leu Phe Leu His Pro Phe Ile Gly Asp Phe Giy Leu Tyr Val Leu Ile 115 120 125 Met Leu Met Val Val Ile Ser Tyr Leu Ile Leu Phe Lys Leu Pro Pro 130 135 140 Lys Ser Val Phe Tyr Pro Tyr Met Asn Lys Thr Gin Ser Leu Leu Lys 145 150 155 160 Giu Ile Tyr Lys Gin Cys Leu Gin Ala Phe Ser Pro Asn Phe Ser Leu 165 170 175 Lys Lys Giu Giy Phe Giu Asn Thr Pro Ser Asp Ser Gin Lys Lys Giu 180 185 190 Thr Asn Asn Asp Lys Giu Lys Giu Asn Leu Lys Giu Asn Pro Ile Asp 195 200 205 Giu Asn His Asn Thr Pro Asn Giu Giu Ser Phe Leu Ala Ile Pro Thr 210 215 220 Pro Tyr Asn Thr Thr Leu Asn Asn Ser Giu Pro Gin Giu Gly Leu Val 225 230 235 240 Gin Ile Ser Pro His Pro Pro Thr His Tyr Thr Ile Tyr Pro Lys Arg 245 250 255 Asn Arg Phe Asp Asp Leu Thr Asn Pro Thr Leu Lys Glu Pro Lys Gin 260 265 270 Giu Thr Lys Giu Arg Giu Pro Thr Leu Lys Lys Giu Thr Pro Thr Thr 275 280 285 so. Leu Lys Pro Ile Met Pro Ile Ser Ala Ser Asn Thr Giu Asn His Asp 290 295 300 .*so Lys Thr Glu Asn His Lys Thr Pro Asn His Pro Ile Lys Giu Asp Asp 305 310 315 320 Leu Gin Glu Ser Pro Gin Giu Asn Pro Gin Lys Glu Asn Ile Giu Glu :st*325 330 335 Asn Ile Giu Glu Lys Glu Thr Gin Asn Ala Pro Ser Phe Ser Pro Leu :340 345 350 Thr Leu Thr Ser Ala Lys Lys Pro Val Met Val Lys Giu Leu Ser Giu 355 360 365 s Asn Lys Giu Ile Leu Asp Gly Leu Asp Tyr Gly Giu Vai Gin Lys Pro Lys G37LuPr 5 380 LsAsp Tyr GuL PoThr Thr Gin Leu Leu Asn Ala Val Cys Leu 385 390 395 400 Lys Giu Thr Ser Leu Asp Giu Asn Giu Ile Asp Gin Lys Ile Gin Asp 405 410 415 Leu Leu Ser Lys Leu Arg Thr Phe Lys Ile Asp Gly Asp Ile Ile Arg 420 425 430 Thr Tyr Ser Gly Pro Ile Val Thr Thr Phe Glu Phe Arg Pro Ala Pro 435 440 445 *Ser Val Lys Vai Ser Arg Ile Leu Gly Leu Ser Asp Asp Leu Ala Met 450 455 460 Thr Leu Cys Ala Giu Ser Ile Arg Ile Gin Ala Pro Ile Lys Gly Lys 465 470 475 480 Asp Val Vai Gly Ile Giu Ile Pro Asn Ser Gin Ser Gin Ile Ile Tyr 485 490 495 Leu Arg Gu Ile .Leu Giu Ser Glu Leu Phe Gin Lys Ser Ser Ser Pro 500 505 510 Leu Thr Leu Ala Leu Gly Lys Asp Ile Val Gly Asn Pro Phe Ile Thr 515 520 525 Asp Leu Lys Lys Leu Pro His Leu Leu Ile Ala Gly Thr Thr Gly Ser 530 535 540 1079 Gly 545 Asn Glu Thr Met Asp 625 Tyr Gly Ala Val Arg 705 Ala Thr Ile Asp Asn 785 Glu Gly Phe Phe Lys Ser Val Gly Val Asn Ala Met Ile Pro Phe Asp Glu 610 Ser Leu Lys Ser Val 690 Val Gin Asn Lys Lys 770 Tyr Lys Tyr Leu Pro Ser Pro 595 Arg Tyr Ile Glu Gly 675 Thr Gly Ser Gly Lys 755 Asp Gin Lys Asn Ser 835 Asp Ile 580 Lys Arg Asn Val Ala 660 Leu Gly Thr Leu Leu 740 Ile Phe Gly Ile Gin 820 Pro Gin 565 Tyr Lys Tyr Glu Val 645 Glu His Leu Lys Leu 725 Val Val Leu Asp Thr 805 Ala Arg Leu Ala Ala Ser Gin 630 Ile Phe Leu Ile Ile 710 Gly Arg Asp Leu Asp 790 Ser Ala Asn Lys Asp Ile Leu 615 Ala Asp Pro Ile Lys 695 Asp Arg Leu Phe Glu 775 Ile Thr Thr Ala Leu Ile Gly 600 Met Gin Glu Ile Val 680 Thr Ser Gly His Ile 760 Glu Leu Ser Ile Lys 840 Val Pro 585 Ala Ser Ser Leu Ala 665 Ala Asn Lys Asp Ala 745 Lys Ser Glu Phe Thr 825 Gly Met 570 His Leu Glu Asn Ala 650 Arg Thr Leu Val Met 730 Pro Ala Arg Arg Leu 810 Asp Asn Leu 555 Ile Leu Gin Tyr Gly 635 Asp Ile Gin Pro Ile 715 Leu Phe Gin Met Ala 795 Gin Glu Arg Ser Asp Leu Ser Lys 620 Val Leu Ala Arg Ser 700 Leu Phe Ala Lys Pro 780 Lys Arg Leu Glu Leu Pro Thr Val 605 Val Glu Met Gin Pro 685 Arg Asp Thr Thr Glu 765 Leu Ala Gin Glu Ile 845 Leu Lys Pro 590 Ala Lys Ala Met Met 670 Ser Val Thr Pro Glu 750 Val Asp Val Leu Ala 830 Leu Tyr Met 575 Ile Lys Thr Phe Thr 655 Gly Val Ser Asp Pro 735 Asp Glu Thr Ile Lys 815 Gin Gin Lys 560 Val Ile Glu Ile Pro 640 Gly Arg Asp Phe Gly 720 Gly Glu Tyr Pro Leu 800 Ile Gly Asn a a a INFORMATION FOR SEQ ID NO:1520: SEQUENCE CHARACTERISTICS: LENGTH: 448 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...448 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1520 Asn Tyr Leu Lys Ile Ser Cys Ser Arg Ile Ala Met Asn Pro Gin Ile 1 5 10 Gin Pro Ala Thr Lys Lys Pro Leu Lys Ser Leu Leu Ala Ala Ser Ser 1080 Gly Asn Leu Val Glu Trp Tyr Asp Phe Tyr Pro Leu Leu Thr Leu Phe 145 Lys Leu GJlu Ile Met 225 Lys Leu Gly Thr Leu 305 Ala Gly Ser Ser Glu 385 Ala His Ile Ala Ala Leu Val1 100 Leu Leu Val1 Tyr Ile 180 Ser Leu Glu His Lys 260 Cys Ser Ser Ile Val1 340 Glu Thr Arg Gly Giu 420 Val1 Lys Phe Phe Pro Ala Ala Gly 165 Phe Ala Leu Ala Ile 245 Lys Phe Ser Lys 325 Thr Ala Cys Ala G ly 405 Giu Met Glu Leu 70 Phe Ser Thr Arg Thr 150 Ser Ser Phe Ser Thr 230 Lys Ala The Phe 310 Arg Pro Leu Ile Leu 390 Ser Gly Val1 Phe Val Gly Ile Lys Leu 135 Phe Leu Ala Leu 215 Pro Giu Leu Thr Ser 295 Ile Thr Ile Phe Ala 375 Gly Ala Phe Ile Thr Phe Lys Ile Glu 120 Leu Leu Gin Phe Trp 200 Phe Gin Thr Met Phe 280 Pro Phe Gin Val1 360 Gly Val1 Ser Val Ile 440 Ala Tyr Asn Asp Gly Phe 75 Asp Lys Ala Leu Gly Glu Phe Ser 140 Leu Gly 155 Thr Leu Glu Asn Leu Phe Asn Ile 220 Thr Asn 235 Gly Ser Phe Gly Tyr Leu Ser Ser 1300 Pro Leu 315 Met Val Gly Ile Leu Ala Lys Ala 380 Ala Tyr 395 Ala Leu Val Met Lys Lys Ala Pro Phe Lys Gly Trp 125 Val1 Lys Val1 Val1 Ala 205 Met Val1 Leu Leu Lys 285 Phe Cys Phe Lys Leu 365 G iu Ala Glu Leu Thr 445 Phe Thr Met G ly Ser 110 Ala Gly As n Gly Tyr 190 Leu Glu As n Lys Thr 270 Ile Ile Gly Ala His 350 Ser Leu Ile Phe Se r 430 Tyr Leu Leu Arg Arg Phe Phe G ly Gly G ly 175 Thr Glu G iu Asn Glu 255 Met Phe Met Met Ile 335 Ala Ser Phe Ala Lys 415 Ile Leu Ala Ala Pro Lys Met Leu Glu Lys 160 Gin His Gly Thr Thr 240 Leu Gly Leu Leu Leu 320 Thr Thr Met Pro Asn 400 Gin Val Glu 0 0 0 *0 toot.
0 too INFORMATION FOR SEQ ID NO:lS2i: SEQUENCE CHARACTERISTICS: LENGTH: 646 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES 1081 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .646 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1521 Trp Lys Asn Leu Met Gin Leu Sen Asn Ala Asp 9* Lys 1 Lys Lys Met Trp Leu Asp Giu Gin Gin 145 Cys Leu Asn Val Giy 225 Sen Ala Lys Giu
LYS
305 Pro Ala Val Phe
LYS
385 Arg Leu Sen Ala Val Leu Val Leu Leu Gly 130 Thn Gly Ala Gin Lys 210 His His Ile Glu Ser 290 Val Lys Ile Ser Leu 370 His Giu Phe Met Asn Val Asn Tyr Lys His 115 Phe Leu Asp Gly Ile 195 Thn Asp
LYS
Gly Val1 275 Phe Arg Thr Asn Asn 355 Gly' Sen His Val Ala Ser Leu Ang Ser Arg 100 His Ala Leu Gly His 180 Sen Arg Tyr Pro Leu 260 Leu Ile Gly Lys 340 Gly Gly Gly Ala* Pro Asn Gly Ser Asp Leu Phe Thr Asn Asp Asp 165 Leu Ile Phe Gin Thr 245 Glu Lys Ile Ile Giu 325 Pro Met Ser Asp Met 405 Phe Thr His Leu Arg 70 Leu Ang Glu Ala Lys 150 Leu Arg clu Leu Aia 230 Leu Gly Gin Sen Ser 310 Lys Ala Ile Ala Phe 390 Gly Cys Leu Pro His 55 Leu His Gin Gly Val1 135 Giu Gin Leu Gly Ala 215 Ile Leu Sen Ser Pro 295 Leu Ile Phe Leu Asp 375 Pro Ala Ala Arg Gly 40 Leu Val1 Leu Leu Ile 120 Gly Ala Giu Asp Ala 200 Gin His Ile G lu Lys 280 Lys Glu H is Lys As n 360 Leu Leu Ile Thr 10 Phe Leu 25 Val Cys Asn Leu Phe Ser Trp Gly 90 His Ser 105 Giu Ile Phe Sen Ile Ser Gly Ile 170 Asn Leu 185 Ile Asn Asn Trp Asn Ala Ala His 250 Lys Thn 265 Giu Asn Asn Lys Ala Leu Ala Leu 330 Lys Gly 345 Ala Ile Ala Pro Gly Gin Thr Asn 410 Phe Phe 425 Cys Leu Asn Gly 75 Phe Lys Thr Met His 155 Sen Ile Ile Glu Leu 235 Thr His Aia Met Trp, 315 Lys G lu Ala Sen Asn 395 Ala Val1 Ala Gly Pro Gly Asp Thr Thr Ala 140 Lys Tyr Vai Ser Val 220 Glu Ile Gly Gin His 300 GJlu Asn Ser Lys Asn 380 Leu Leu Phe Leu Asp Leu Thr His Leu Pro Ala 125 Ser Val Giu Ile Phe 205 Leu Giu Ile Ser Ile 285 Phe Lys Phe Leu Giu 365 Asn His Ala Ser Giu Met Ala Asn Ala Ser Gly 110 Pro Gin Tyr Ser 190 Ser Giu Ala Gly Pro 270 Asn Glu Ser Asp Aia 350 Cys Thr Phe Ala Asp Arg Ile Asp Pro Sen Leu His Leu Tyr Cys Thr 175 Asp Giu Cys Lys Lys 255 Leu Pro Giu Leu Phe 335 Thr Giu His Gly Tyr 415 Tyr Leu Asp Val Lys Ala Asp Pro Gly Ala Leu 160 Sen Sen Gin Asp Lys 240 Gly Ser Asn Val Ser 320 Asn Arg Gly Leu Ile 400 Gly Leu 420 Met Pro Ser Ile Arg..Leu Ser Ala Leu Met Lys Leu Lys Ala Leu Phe 1082 435 440 445 Ile Phe Thr His Asp Ser Ile Gly Val Gly Glu Asp Gly Ala Thr His 450 455 460 Gin Pro lie Glu Gin Leu Ser His Leu Arg Ala Leu Pro His Phe Tyr 465 470 475 480 Ala Phe Arg Pro Ser Asp Ala Phe Glu Asn Lys Ala Cys Met Gin Val 485 490 495 Ala Leu Ser Leu Asn Ala Pro Ser Ala Leu Ile Leu Ser Arg Gin Asn 500 505 510 Leu Ser Val Leu Asp Glu Val Ser Lys Glu Gin Val Leu Lys Gly Ala 515 520 525 Tyr Val Lys His His Ser Lys Asp Pro Ile Ile Thr Leu Val Ala Ser 530 535 540 Gly Ser Glu Val Ser Leu Ala Leu Glu Ser Ala Lys Ile Leu Glu Arg 545 550 555 560 Glu Asn Ile Pro Thr Gin Val Val Ser Ala Pro Cys Phe Asp Leu Leu 565 570 575 Val Glu Gin Asp Glu Ser Tyr Phe Lys Glu Leu Phe Lys Gly Lys Val 580 585 590 Leu Val Ile Glu Ala Ser Arg Ala Ile Glu Trp Tyr Arg Phe Ala Asp 595 600 605 Lys Ile Ile Gly Met Asp Ser Phe Gly Ser Ser Ala Lys Gly Asp Lys 610 615 620 Leu Phe Glu Lys Phe Gly Phe Ser Val Glu Asn Ile Thr Ala Gin Ala 625 630 635 640 Lys Arg Leu Leu Asn Ala 645 INFORMATION FOR SEQ ID NO:1522: SEQUENCE CHARACTERISTICS: LENGTH: 273 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...273 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1522 Lys Asp Tyr Cys Met Gin Asn Gly Tyr Tyr Ala Ala Thr Gly Ala Met 1 5 10 Ala Thr Gin Phe Asn Arg -Leu Asp Leu Thr Ser Asn Asn Leu Ala Asn 20 25 Leu Asn Thr Asn Gly Phe Lys Arg Asp Asp Ala Ile Thr Gly Asp Phe 40 Leu Arg Leu Tyr Gin Glu Tyr Arg Glu Gin Leu Pro Leu Glu Asp Gin 55 Thr Lys Ala Ser Ala Lys Tyr Leu Asn Arg Asn Leu Asn Arg Val Pro 70 75 Ile Leu Ser Glu Ile Tyr Thr Asp Arg Ser Leu Gly Ala Phe Glu Gly 90 Thr Asn Asn Pro Leu Asp Phe Ala Leu Thr Ser Pro Asn Leu Tyr Phe 100 105 110 Ala Ile Gin Thr Asn Glu Gly Val Ala Tyr Thr Lys Asp Gly His Phe 115 120 125 1083 Ser Val Asp Lys Asp Gly Phe Leu Val Thr Leu Asn Gly Phe Lys Val 130 135 140 Leu Ser Arg Ser Gly Leu Asn Glu Lys Gly Gly Ile Met Leu Met Pro 145 150 155 160 Asn Ala Giu Ile Giu Val Asp Gin Asn Gly Gly Ile Thr Phe Arg Asp 165 170 1.75 Asn Glu Ala Gin Ile Gin Ala Gly Ala Leu Ala Leu Val Ser Phe Ser 180 185 190 Glu Pro Lys Asn Leu Lys Lys Ile Gly Gin Asn Leu Tyr Thr Tyr Gin 195 200 205 Gly Giu Gly Val His Gin Val Ser Asp Ser Gly Ala Leu Arg Gin Ser 210 215 220 Met Leu Giu Lys Ser Asn Val Asn Ala Val Arg Giu Met Ser Thr Leu 225 230 235 240 Ile Giu Ile Asn Arg Phe Leu Asp Met Tyr Ser Lys Val Leu Lys Thr 245 250 255 His Gin Asp Asp Met Asn Ala Giu Ala Ile Asn Lys Leu Ala Thr Lys 260 265 270 Ala INFORMATION FOR SEQ ID NO:1523; SEQUENCE CHARACTERISTICS: LENGTH: 592 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGAN~ISM: Helicobacter pyloni se:.(ix) FEATURE: NAME/7KEY: misc-feature LOCATION 1 .592 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1523 Gly Met Ile Ala Leu Asn Phe Asn Leu Leu Asp Lys Glu Thr Asn Thr 1 5 10 Pro Leu Phe Glu Lys Ser Pro Leu Asp Ser Ser Leu Glu Leu Tyr Lys 20 25 Asn Ser Giu Ile His Met Leu Tyr Pro Tyr Leu Tyr Tyr Phe Gly Leu 40 Gly Asn Gly Val Phe Tyr Arg Leu Leu Leu Gly Asn Glu Asn Leu Lys 55 Arg Leu Val Va1 Ile Glu Pro Glu Ile Glu Val Ile Phe Ile Val Leu 70 75 Asn Leu Leu Asp Phe Ser Thr Glu Ile Leu Glu Asn Arg Leu Ile Leu :85 90 Leu His Ala Ser Phe Cys Asn Tyr Asn Met Ile Ala Ser Leu Phe Asp 100 105 110 Met Asp Lys Lys Ser Arg Leu Tyr Ala Arg Met Tyr Asp Leu Lys Leu 115 120 125 Phe Asn Ala Tyr Tyr Glu Arg Tyr Ser His Gin Met Ile Glu Ile Asn 130 135 140 Gin His Phe Thr Arg Ala Leu Glu His Gly Ala Ile Ser Val Gly Asn 145 150 155 160 Asp Ala Lys Asp Ala Leu Ile Gly Ile Lys Gin His Val Ala Asn Leu 165 170 175 Pro Glu Val Ile Lys Ser Pro Ser Leu Val Asp Phe Val Asn Ala Leu 1084 180 185 190 Lys Asn Arg Asp Thr Ala Ile Ile Val Ser Thr Gly Pro Ser Leu Asn 195 200 205 Lys Gin Leu Pro Leu Leu Lys Glu Ile Ala Pro Tyr Ala Thr Leu Phe 210 215 220 Cys Ile Asp Ala Ser Phe Pro Ile Leu Ala Arg Ala Gly Ile Lys Pro 225 230 235 240 Asp Ile Val Leu Ser Leu Giu Arg Val Asp Leu Thr Ala Lys Phe Tyr 245 250 255 Giu Giu Thr Pro Leu Asp Phe Gin Giu Gly Val Ile Phe Ala Leu Thr 260 265 270 Ser Ile Val His Lys Arg Leu Ile Gin Ala Ile Gin Lys Giy Val Lys 275 280 285 Gin Phe Ser Phe Arg Pro Phe Gly Tyr Thr Asn Leu Phe Asp Leu His 290 295 300 Gin Tyr Gly Tyr Val Gly Ile Gly Met Ser Ala Ala Asn Met Ala Tyr 305 310 315 320 Glu Leu Vai Val His Ser Arg Phe Lys Arg Cys Val Phe Ile Gly Gin 325 330 335 Asp Leu Ser Phe Ser Gin Ser Gly Asn Ser His Ala Ser Giy Ala Ile 340 345 350 Tyr Gly A-sp Arg Giu Ile Lys Pro Lys Lys Asp Lys Asp Lys Ile Phe 355 360 365 Ile Giu Lys Tyr Gly Gly Asn Gly Lys Vai Giu Thr Thr Leu Vai Trp 370 375 380 Lys Leu Phe Leu Giu Phe Phe Glu Lys Asp Ile Phe Asn Thr Pro Tyr 385 390 395 400 Lys Leu Giu Val Ile Asn Ala Thr Giu Gly Gly Ala Arg Ile Lys Gly 405 410 415 Tlir Lys Giu Met Pro Phe Lys Giu Val Cys Giu Lys Ile Asp Lys Ser 420 425 430 Lys Pro Lys Pro Pro Ile Asn Leu Ile Tyr Pro Thr Gin Ser Glu Gin 435 440 445 Ala Lys Asn Leu Lys Ile Ala Lys Lys Lys Cys Giu Giu Ile Ile Lys *450 455 460 Tyr Aia Asn Giu Lys Lys Thr Gin Val Glu Glu Ala Phe Leu Lys Vai *465 470 475 480 Ala Giu Phe Leu Giu Lys Val Giu Lys Leu His Giu Lys Asn Lys Leu 485 490 495 Giu Giu Leu Asp Phe Glu Giu Leu Glu Asn Leu Ser Ala Giu Ile Asp 505 510 Asn Vai Lys Giu Leu Phe Asp Asp Lys Arg Phe Asn Ser Tyr Phe Met s Aa515 520 525 As lIle Gin Ser Tyr Ile Phe His Gin Giu Leu His Ile Ala Giu *530 535 540 Ile Val Cys Lys Lys Thr Ser Asn Giu Asp Gly Leu Arg Ala Lys Gin 545 550 555 560 Leu Giu Tyr Ile Tyr Ala His Lys Tyr Trp Leu Phe Ser Leu Ala Gly *565 570 575 *Giy Met Asp Cys Val Ile Giu Ala Ile Lys Met Aia Leu Lys Giu Trp 580 585 590 INFORMATION FOR SEQ ID NO:1524: SEQUENCE CHARACTERISTICS: LENGTH: 116 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: 1085 ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...116 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1524 Val His Phe Thr Cys Ile Phe Leu Thr Leu Leu Lys Trp Ile Leu Pro 1 5 10 Ala Lys Asn Lys Gin Ala Cys Lys Lys Pro Pro Thr Arg Ser Ile Gin 25 Gly Leu Gin Asn Ile Gin Gin Asn Ile Pro Pro Gin Val Leu Thr Pro 40 Gin Ile Gin Ala Gly Ile Gin Gly Val Met Gin Gly Phe Gly Ala Leu 55 Ser Ser Thr Leu Glu Ala Pro Leu Leu Phe Ser Lys Gin Asn Val Val 70 75 Ile Gly Gly Phe Glu His Tyr Leu Ser Pro Leu Tyr Gly Trp Gly Lys 90 Ile His Asp Gly Ala His Cys Arg Ile Glu Cys Lys Lys Thr Pro Met 100 105 110 Lys Cys Ile Ala 115 INFORMATION FOR SEQ ID NO:1525: SEQUENCE CHARACTERISTICS: LENGTH: 377 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein S* (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...377 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1525 99 Arg Met Asn Phe Phe Lys Ile Leu Leu Met Glu Leu Arg Ala Ile Val 1 5 10 Ser His Lys Gly Val Leu Leu Ile Leu Ile Gly Ala Pro Leu Ile Tyr 25 *Gly Leu Leu Tyr Pro Leu Pro Tyr Leu Lys Asp Ile Val Thr Gin Gin 40 Lys Ile Ala Leu Val Asp Glu Asp Asn Ser Phe Leu Ser Arg Gin Leu 50 55 Ala Phe Met Val Gin Ser Ser Asn Glu Leu Glu Ile Ala Phe Phe Ser 70 75 Pro Ser Met Leu Glu Ala Lys Lys Leu Leu Lys Glu Glu Lys Ile Tyr 90 Gly Ile Leu His Ile Pro Ser His Phe Glu Ala Asn Ile Tyr Lys Gin 100. 105 110 Val Pro Val Thr Ile Asp Phe Tyr Ala Asn Ala Asn Tyr Phe Leu Ile 115 120 125 Tyr Gly Ala Leu Ala Asn Ala Val Val Gly Ser Ile Asn Ala Leu Asn 130 135 140 Asp Glu Ile Arg Phe Lys Arg Asn Ala Gin Ile Glu Glu Ala Glu Leu 1086 145 150 155 160 Gly Thr Asp Gly Ile Lys Ile Lys Pro Ile Ala Leu Tyr Asn Pro Ser 165 170 175 Glu Gly Tyr Leu Asn Tyr Ala Leu Ser Ser Val Phe Ile Phe Ile Leu 180 185 190 His Gin Val Met Leu Ile Ala Ser Ser Met Phe Thr Ser Ser Arg Arg 195 200 205 Leu Glu Leu Ala Leu Leu Asp Lys Lys Gin Ile Ala Leu Arg Leu Cys 210 215 220 Ala Arg Leu Leu Val Phe Met Gly Ala Phe Ser Val Phe Val Leu Trp 225 230 235 240 Tyr Phe Gly Ala Leu Phe Ser Phe Tyr Gly Ile Glu Arg His Gly Ser 245 250 255 Ala Leu Met Val Phe Leu Asn Ser Leu Ile Phe Met Leu Ala Ala Leu 260 265 270 Ser Leu Gly Ser Phe Leu Gly Ala Trp Ile Lys Asn Glu Ala His Thr 275 280 285 Thr Gin Ile Val Leu Ile Ser Ser Leu Pro Leu Ile Phe Met Met Gly 290 295 300 Phe Val Trp Pro Phe Glu Ser Leu Pro Ser Tyr Leu Gin Val Phe Val 305 310 315 320 Gin Ile Val Pro Ala Tyr His Gly Ile Ser Leu Leu Gly Arg Leu Asn 325 330 335 His Met His Ala Glu Phe Ile Asp Val Tyr Ile His Phe Tyr Ala Leu 340 345 350 Ile Ala Ile Phe Ile Val Ser Phe Ile Gly Cys Val Phe Lys Leu Ser 355 360 365 Ser Leu Lys Lys Ala Cys Glu Asn Ala 370 375 INFORMATION FOR SEQ ID NO:1526: SEQUENCE CHARACTERISTICS: LENGTH: 89 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...89 S(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1526 Thr Leu Lys Gly Ile Val Leu Phe Arg Leu Ile Ser Ala Trp Val Leu 1 5 10 Gin Asp Lys Phe Leu Phe Val Val Cys Phe Ile Leu Pro Phe Cys Leu 25 Gly Val Leu Gly Thr Gin Ile Phe Lys Gin Glu Thr Pro Arg Gin Leu 40 Pro Ile Val Val Val Asp Leu Asp Lys Thr Thr Thr Ser His Gin Val 55 Ala Phe Glu Leu Gly Ala Thr Ser Ala Val Glu Ile Lys Tyr Gin Val 70 75 Thr Ser Leu Ser Glu Ala Lys Arg Phe 1087 INFORMATION FOR SEQ ID NO:1527: SEQUENCE CHARACTERISTICS: LENGTH: 77 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...77 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1527 Ser Met Lys Lys Thr Thr Leu Phe Val Leu Gly Leu Leu Phe Asn Ser 1 5 10 Ser Leu Ser Ala Val Asp Gly Ile Ser Gin Thr Glu Pro Ser Ser Leu 25 Asn Leu Ala Glu Asp Ser Leu Pro Leu Asn His Ser Asn Ala Gin Lys 40 Leu Ser Leu Lys Asn Ala Trp Asn Arg Val Leu Ser Asn His Glu Gly 55 Leu His Ala Gin Asn Thr Pro Leu Ser Glu Arg Val Lys 70 INFORMATION FOR SEQ ID NO:1528: SEQUENCE CHARACTERISTICS: LENGTH: 101 amino acids TYPE: amino acid o TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: S(A) ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...101 xi) SEQUENCE DESCRIPTION: SEQ ID NO:1528 Val Arg Arg Gin Thr Met Lys Lys Val Ile Val Ala Leu Gly Val Leu 1 5 10 Ala Phe Ala Asn Val Leu Met Ala Thr Asp Val Lys Ala Leu Val Lys 25 Gly Cys Ala Ala Cys His Gly Val Lys Phe Glu Lys Lys Ala Leu Gly 40 Lys Ser Lys Ile Val Asn Met Met Ser Glu Lys Glu Ile Glu Glu Asp 55 Leu Met Ala Phe Lys Ser Gly Ala Asn Lys Asn Pro Val Met Thr Ala 70 75 Gin Ala Lys Lys Leu Ser Asp Glu Asp Ile Lys Ala Leu Ala Ile Tyr 90 Ile Pro Thr Leu Lys 1088 100 INFORMATION FOR SEQ ID NO:1529: SEQUENCE CHARACTERISTICS: LENGTH: 159 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...159 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1529 Arg Pro Met Leu His Lys Lys Tyr Arg Pro Asn Val Ala Ala Ile Ile 1 5 10 Met Ser Pro Asp Tyr Pro Asn Thr Cys Glu Val Phe Ile Ala Glu Arg 25 Ile Asp Ile Glu Gly Ala Trp Gin Phe Pro Gin Gly Gly Iie Asp Glu 35 40 S* Gly Glu Thr Pro Leu Glu Ala Leu Tyr Arg Glu Leu Leu Glu Glu Ile 50 55 Gly Thr Asn Glu Ile Glu Ile Leu Ala Gln Tyr Pro Arg Trp Ile Ala 65 70 75 Tyr Asp Phe Pro Ser Asn Met Glu His Lys Phe Tyr Ser Phe Asp Gly 90 Gin Lys Gin Arg Tyr Phe Leu Val Arg Leu Lys His Val Asn Asn Ile 00 105 110 Asp Leu Asn Lys His Thr Pro Glu Phe Arg Ser Tyr Gin Phe Ile Gin 115 120 125 Leu Lys Asp Leu Leu Lys Lys Ile Val Pro Phe Lys Arg Gin Val Tyr 130 135 140 Arg Gln Val Ile Ala Tyr Phe Arg Lys Glu Gly Tyr Leu Gly Cys 145 150 155 INFORMATION FOR SEQ ID NO:1530: SEQUENCE CHARACTERISTICS: LENGTH: 131 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...131 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1530 1089 Cys Met Asn Leu Val Phe Leu Trp Ala Ala Leu Gly Gly Ala Ile Gly 1 5 10 Ser Ser Leu Arg Tyr Phe Val Gly Lys Met Met Pro Ser Lys Phe Leu 25 Met Phe Glu Ser Phe Pro Leu Gly Thr Phe Ser Val Asn Leu Ile Gly 40 Cys Phe Ile Ile Gly Phe Met Gly His Leu Ala Ala Lys Lys Val Phe 55 Gly Asp Asp Phe Gly Ile Phe Phe Val Thr Giy Val Leu Gly Gly Phe 70 75 Thr Thr Phe Ser Ser Tyr Gly Leu Asp Thr Leu Lys Leu Leu Gin Lys 90 Ser Gin Tyr Leu Glu Ala Ile Ser Tyr Val Leu Gly Thr Asn Leu Leu 100 105 110 Gly Leu Ile Gly Vai Ala Ile Gly Trp Phe Leu Ala Lys Asn Phe Val 115 120 125 Gly Val Asn 130 INFORMATION FOR SEQ ID NO:153i: SEQUENCE
CHARACTERISTICS:
LENGTH: 273 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL.:
YES
(vi) ORIGINAL~
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NME/KEY: misc-feature LOCATION .273 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:15.3i Tyr Leu Ser Ile Val Val Giu Asp Gin Lys Gly Ile Phe Pro Ile Ala o1 5 10 0*00 Ala Ser Lys Arg Lys Ser Gin Ser Ser Val Ile Ile Giu Asp Val Cys 25 Phe Ser Lys Giu Asp Phe Val Glu Gly Ala Lys Ala Ile Giu Gly Leu 35 40 Leu Lys Lys His Gly Phe Lys Asp Asn Gly Ile Ile Phe Gly His Ala 55 Leu Ser Gly Asn Leu His Phe Val Vai Thr Pro Ile Leu Giu Asn Giu 70 75 Ala Glu Arg Lys Ala Phe Giu Asn Leu Val Ser Giu Met Phe Leu Met 90 Val Ser Lys Ser Ser Gly Ser Ile Lys Ala Glu His Giy Thr Gly Arg 100 105 110 Met Val Ala Pro Phe Val Giu Met Giu Trp Gly Giu Lys Ala Tyr Lys 115 120 125 Ile His Lys Gin Ile Lys Glu Leu Phe Asp Pro Asn Gly Leu Leu Asn 130 135 140 Pro Asp Val Ile Ile Thr Asn Asp Lys Glu Ile His Thr Lys Asn Leu 145 150 155 160 Lys Ser Ile Tyr Pro Ile Giu Glu His Leu Asp Met Cys Met Giu Cys 165 170 175 Gly Phe Cys Glu Arg Ile Cys Pro Ser Lys Asp Leu Ser Leu Thr Pro 180 185 190 Arg Gin Arg Ile ValIle His Arg Giu Val Giu Arg Leu Lys Giu Arg 1090 195 200 205 His Gly His Asp Glu Asp Gin Val Leu Leu Asp Giu Leu Leu 215 220 Ser Glu Tyr Leu Ala His Ala Thr Cys Ala Val Cys His Met 230 235 240 Thr Leu Cys Pro Leu Gly Ile Asp Thr Gly Ser Ile Ala Leu 245 250 255 Tyr Gin Lys Asn Pro Lys Gly Glu Lys Ile Cys Phe Lys Asp 260 265 270 INFORMATION FOR SEQ ID NO:1532: SEQUENCE CHARACTERISTICS: LENGTH: 241 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .241 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:l532 C Arg Glu Asn Pro Asn Ile Asp Phe Sen Glu 145 Leu Ile Val1 Ile Leu 225 Lys Giu Sen Gly Asn Thr Lys Asp 115 Pro Leu Asp Giu Thr 195 Leu As n Leu Ala Lys Leu 100 Phe Leu Gin Glu Leu 180 His Lys Leu Lys Gly Gin Lys Thr Asp Lys Leu Pro 165 Ile Leu Glu Thr Leu Lys Gly Ser Pro Giu Ang Ile 150 Val1 Ala Val1 Ala Thn Lys 40 Thr Val1 Ala Lys Lys 120 Phe Thr Gly Giu Asp 200 Val1 Tyr Gin Leu Lys Phe Ala 105 Ala Lys Leu Ile Phe 185 Val1 Val1 Gly Gin Leu Ile Leu Ile Leu Ala Ser Asp 170 Ser Glu Ala Phe Leu Gin Lys Ser Ala Gin Ile Trp Gly Ile Lys Lys Gly Leu Gin Gly Leu 125 Lys Ala Ala Ala Leu 205 Asp Lys Lys Lys Gly Tyr Ser Ser Leu Glu Ala 230 1091 INFORMATION FOR SEQ ID NO:1533: SEQUENCE CHARACTERISTICS: LENGTH: 288 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .288 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1533 a a.
9* 9 9 Lys Thr Cys Leu Gin Asp Val1 Ala Val1 Ile 145 Ala Ser Thr Pro Phe 225 Phe Leu Ile Phe Val His Val1 Ile Leu 115 Thr Pro Ile Sen Gly 195 Ile Ser Thr Pro Ang 275 Ile Lys Ser Lys Ile Leu 100 Glu Asp Phe Ala Gly 180 Sen Tyr Thr Ser Lys 260 Gly
S
Gly Met Asp Ile Thr Ala G ly Tyr Tyr Ser 165 Cys Phe Val1 Ser His 245 As n Phe Gly Arg Lys 55 Giu Ser Lys Ile Lys 135 Gin Lys Ile Met Asp 215 Lys Trp Leu Met Trp 40 Glu Ile Gly Val Lys 120 Leu Asp Asp Asp Gin 200 Ile Arg Gly Asp As n 280 Lys Ala Leu Ala Met Gin Asp Lys Ile Leu Asp Thr Arg Giy Asn. Glu 140 Ser Giy 155 Tyr Lys Ile Trp His Leu Leu Tyr 220 Giy Phe 235 Tr Leu Phe Thr Ala Arg Sen Tnp Phe Phe Tyr Ala Pro Phe Tyr Giy Leu Trp Lys Val1 Arg Val1 Leu Lys Glu 125 Lys Ile Ile His Ser 205 Leu Leu Gin Pro Tyr 285 INFORMATION FOR SEQ ID NO:1534: SEQUENCE CHARACTERISTICS: LENGTH: 149 amino acids TYPE: amino acid 1092 TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...149 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1534 Ile Val Arg Lys Lys Leu Met Leu Glu Met Ser Leu Gin Ala Leu Asn 1 5 10 Thr Gin Asp Ser Ser Val Met Ala Gin Ser Leu Leu Val His Ala Phe 25 Phe Ala Ala Leu Leu Ala Leu Ala Phe Met Ile Asn Leu Tyr Thr Leu 40 Phe Lys Glu Lys Asn Phe Ile Gin Leu Asn Arg Lys Ile Tyr Leu Val 55 Met Pro Ala Ile Tyr Ile Leu Leu Ser Ile Ala Leu Leu Ser Gly Val 70 75 Phe Ile Trp Ala Met Gin Gin Phe Glu Phe Ser Phe Ser Ala Val Val 90 Met Leu Leu Gly Leu Leu Leu Met Leu Ile Ala Glu Ile Lys Arg His 100 105 110 Lys Ser Val Lys Phe Ala Ile Thr Lys Lys Glu Arg Met Lys Ala Tyr 115 120 125 SIle Lys Lys Ala Lys Ile Leu Tyr Phe Leu Glu Thr Ile Leu Ile Ile 130 135 140 Val Leu Met Gly Ile 145 INFORMATION FOR SEQ ID NO:1535: SEQUENCE CHARACTERISTICS: LENGTH: 119 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: mrisc_feature LOCATION 1...119 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1535 Pro Glu Gly Gly Asn Glu Leu Asn Val Phe Glu Pro Val Ile Ala Tyr 1 5 10 Lys Leu Phe His Ser Phe Val Ile Leu Gly Cys Ala Ile Glu Thr Leu 25 Thr Thr Lys Cys Val Glu Gly Ile Thr Ala Asn Glu Lys Ile Cys His 40 Asp Tyr Val Phe Asn Ser Ile Gly Ile Val Thr Ala Leu Asn Pro His 55 Ile Asp Giu Ala 1093 Gly Tyr Glu Lys Ser Ala Met Ile Ala Lys Glu Ala Leu Lys Ser 70 75 Arg Ser Ile Tyr Asp Ile Ala Leu Glu Lys Lys Ile Leu Thr Lys 90 Gin Leu Asp Asp Ile Phe Lys Pro Glu Asn Met Leu Ser Pro His 100 105 110 Phe Lys Lys His Lys Asp 115 INFORMATION FOR SEQ ID NO:1536: SEQUENCE CHARACTERISTICS: LENGTH: 235 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .235 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1536 Lys Arg Leu Met Val Leu Phe Leu Ser Ile Phe Lys
S
1 Asp Leu Ile Ala Ala Val Tyr Ser Leu 145 Gly Lys Ser Ser Ala 225 Phe Ser Val 50 His Leu Ile Leu Ile 130 Leu Val Asn Tyr Phe 210 Thr Leu Leu 3S As n Ser Val Asn His 115 Leu Phe Phe Thr Gin 195 Phe Leu Ser Ala Tyr Gin Tyr Ile 100 Gin Phe Leu Gly Met 180 As n Cys Leu 5 Ala Phe Cys Gly Phe Phe Lys Ser Ala Val1 165 Ser Leu Tyr Gin Arg Met Phe Gly Gin Thr Phe Phe 70 Leu Ile Ala Ser Tyr Tyr Ile Lys 135 Val Leu 150 Phe Phe Leu- Asp Leu Lys Leu Phe 215 Thr Leu Leu Ala 40 Leu Ala Phe Ile Pro 120 Tyr Thr Ser Ile Gin 200 Ser Met Leu Ile Leu Gly Trp Phe 105 His Phe Pro Ile Ala 185 His Leu Leu 10 Ile Phe Pro Val Ile 90 Tyr Vai Leu Leu Val1 170 Ser Ang Ile Thr Asri Tyr Gin Phe 75 Val Thr Val1 Lys Tyr Pro Met Leu Pro His 235 Lys Gly Asn Leu Trp Leu Leu Giu 125 Leu Ile Phe Phe His 205 Phe Phe Ile Gly Asp Phe Ser Val1 Phe Phe Phe Phe 175 His Arg Phe As n Leu Ser Tyr Lys Leu Ser Gly Met Ile 160 Phe Gin Phe Phe
S
INFORMATION FOR SEQ ID NO:1537: SEQUENCE CHARACTERISTICS: 1094 LENGTH: 277 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .277 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1537 a.
a a a. a a a a Glu Leu Tyr Ile Gly His Gly Trp Leu Sen 145 Asn Tnp Lys G ly 225 Ang Thr Tyr Sen Ile Tyr Leu Sen Tyr Phe Giy 130 Trp Ala Lys dly Sen 210 Val Val Asn Asn Ala Gly Asn Thr Lys Lys G ly 115 Lys Gly Sen Sen Pro 195 Thr Arg Pro Leu Tyr 275 Val1 Thr Thr Ala Lys 100 Phe Gin Val1 Phe Ser 180 Asp As n Ala Leu Tyr 260 Thr Sen Gin Cys His Gly Gin Tyr Ala 135 Asp Phe As n Thn Thr 215 Tyr Asn.
Leu Leu Gly Gly Pro Leu Lys 105 Leu Asn Leu Gly Trp 185 Thr Aia His Phe Arg 265 Leu Gin Ser Gly Asn Sen Phe Lys Ala Val 170 Lys Tyr Phe Asn Leu 250 Asp Cys Lys Gly Met Glu Phe Met Lys Lys Phe Val Ala Gly Leu G iy Asn G ly Met Gly 125 Leu Ile Gly Ile Pro 205 Trp Glu Gly Leu INFORMATION FOR SEQ ID NO:1538: SEQUENCE CHARACTERISTICS: LENGTH: 676 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES 1095 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...676 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i538 Ala Phe Giu Glu Leu Giu Pro Leu Ser Phe Ser Phe Asn Ser Pro Lys
S
S. *e*S
S
S
1 Gly A Ile S Lys V Gly P Leu Ile S Ile I Asp Lys 2 145 Phe I Thr I Ile Leu Glu 225 Gly Asp Asn Asp Val 305 Thr Glu Asn Cys Thr 385 Gin Val la er 'al i0 'he Lsn ;er :le ryr lan eu iis Leu ly 210 Ser Val Thr Thr Phe 290 Val Al Pr Asi Il 37' Le Se Ii Cys Lys Ile Cys Lys Phe Gin 115 Met Ser Thn Phe Lys 195 Gin Leu Leu Leu 275 Val Ph( Lei o Prc n Iii e Th: 0 Le r Le' e Ty 5 Giu S Ile L Phe G Thr Glu C His I 100 Ile I Ser C Sen I Lys Asn 180 Glu Leu Arg Tyr Lys 260 Ile Val Ser i Tyr Lys 340 Lys 5 r Giy u Pro u Asn n Leu 420 er eu ly .1rn ;in 'he la ;lu .eu Pro 165 Tyr Ile Thr Ile Vai 245 Leu Vai Asp Gly Leu 325 Glu Asn Val Thi GIl 405 Asi Cys Leu G Asp Pro P 4 Tyr Asn P 55 Asn Gly I 70 Gin Asp I Lys Asn I Tyr Asp I Lys Thr 135 Sen Val 150 Ile Glu Leu Asn Leu Glu Leu Gly 215 Arg Ile 230 Leu Asp Ile Asn Val Glu Ile Gly 295 Ser Val 310 Asn Gly Lys-His Leu Ser Ser Gly 375 Ala Gin 390 Val Glu Gin Ala liy L 2 rsn I1 0 ~rg :le la I jer 4et 120 :ys Giu Giu 4 Arg 200 Arg Ala Glu Thr His 280 Pro Lys Thr Phe Va1 360 Sen Thr Ile Pro 1 eu 55 :hr er tsp jeu ?ro 105 Phe Ser aVal VJal Gin 185 Val Asp Ser Pro Let 265 Asi Ly Asy Ly Le' 34 Gi: G1 Le Va
I
42 10 Gly T Pro L Tyn r Ser 2 7 Leu 'I Leu I Lys C Sen Ala Tyr I 170 Glu Phe Ala Gin Sen 250 Arg Lys s Ala p Leu Lys 330 Glu 5 n Ile y Lys u Leu 1 Gly 410 e Gly 5 'hr ,eu .'yr la 55 ,yr .ys ;lu :ys 31y 155 iis Liys Phe Arg Ile 235 Ile Asn Glu Gly Leu 315 Ile Ile Pro Ser Asr 39! Let Lyr Lys P Asn G 4 Ala C Leu C Gly I Arg Gin I Asn C 140 Leu Phe Lys Leu Thn 220 Gly Gly Leu Thr Arg 300 Gin Glu Lys Leu Ser 380 His Glu s Thr 'he In ;in ys tsn ?ro .ys 125 ;ly Lys Phe Ile Tyr 205 Ile Ser Leu Gin Ile 285 His Asn Arg Asn Lys 365 Leu Ala TY2 Prc 1 Ser L Gly P Met I Phe Gly 1J Trp I 110 Asp I His 2 Met Asn Ala 190 Asp Ser I Gly His Lys 270 Lys Gly Asn Pro Val 350 Gin Ile Lys 7 Leu o Arg 1 eu la 'he LSf Chr .ys eu krg la ksp 175 Giu Vlal Gly Leu Glu 255 Lys His Gly His Lys 335 Asn Leu Leu Lys Asp 415 Ser Asp Ile Glu Glu Glu Gly Ser Leu Asp 160 Pro Pro Gly Gly Thr 240 Lys Gly Ala Glu Sen 320 Phe Ile Va1 Gin Asn 400 Lys Asn 430 Pro Ala Thr Tyr Thr Giy Val Met Asp Giu le Arg Ile Leu Phe Ala 1096 435 440 445 Glu Gin Lys Glu Ala Lys Ile Leu Gly Tyr Ser Thr Ser Arg Phe Ser 450 455 460 Phe Asn Val Lys Gly Gly Arg Cys Glu Lys Cys Gin Gly Asp Gly Asp 465 470 475 480 ile Lys Ile Glu Met His Phe Leu Pro Asp Val Leu Val Gin Cys Asp 485 490 495 Ser Cys Lys Gly Ala Lys Tyr Asn Pro Gin Thr Leu Glu Ile Lys Val 500 505 510 Lys Gly Lys Ser Ile Ala Asp Val Leu Asn Met Ser Val Glu Glu Ala 515 520 525 Tyr Glu Phe Phe Ala Lys Phe Pro Lys Ile Ala Val Lys Leu Lys Thr 530 535 540 Leu Ile Asp Val Gly Leu Gly Tyr Ile Thr Leu Gly Gin Asn Ala Thr 545 550 555 560 Thr Leu Ser Gly Gly Glu Ala Gin Arg Ile Lys Leu Ala Lys Glu Leu 565 570 575 Ser Lys Lys Asp Thr Gly Lys Thr Leu Tyr Ile Leu Asp Glu Pro Thr 580 585 590 Thr Gly Leu His Phe Glu Asp Val Asn His Leu Leu Gin Val Leu His 595 600 605 Ser Leu Val Ala Leu Gly Asn Ser Met Leu Val Ile Glu His Asn Leu 610 615 620 Asp Ile Ile Lys Asn Ala Asp Tyr Ile Ile Asp Met Gly Pro Asp Gly 625 630 635 640 Gly Asp Lys Gly Gly Lys Val Ile Ala Ser Gly Thr Pro Leu Glu Val 645 650 655 Ala Gin Asn Cys Glu Lys Thr Gin Ser Tyr Thr Gly Lys Phe Leu Ala 660 665 670 Leu Glu Leu Lys 675 675 e INFORMATION FOR SEQ ID NO:1539: SEQUENCE CHARACTERISTICS: LENGTH: 276 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...276 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1539 Ala Arg Phe Val Lys Ile Thr Ala Asp Tyr Phe Ser Pro Met Glu Asn 1 5 10 Val Phe Tyr Arg Ser Ile Thr Met Thr Leu Leu Leu Leu Leu Ile Tyr 25 Pro Phe Lys Pro Tyr Arg Leu Lys Ser Tyr Lys Gin Gly Gly Phe Lys 40 Lys Leu Ala Phe Arg Val Val Val Gly Gly Leu Ala Met Leu Ala Phe 55 Phe Tyr Asn Ile Glu Lys Ile Ser Leu Ala Thr Ala Asn Ala Phe Ser 70 75 Gin Cys Ala Pro Ile Tyr Thr Val Leu Leu Ser Pro Leu Leu Leu Lys 90 1097 Clu Lys Leu Lys Arg Ser Ala Leu Ile Ser Ala Cys Ile Gly Leu Val 100 105 Gly Val Glu Ile 130 'le Thr 145 Leu Ala Ile Asp Asp Ile Tyr The 210 Pro Ile 225 Leu Giy Val1 115 Ile Leu Phe Ile Leu 195 Leu Glu Asp Leu Met Arg Ala Pro 180 Trp Thr Thr Ile Gly Asp Phe 165 Phe Ile Thr Phe 245 Ser Ile Leu 150 Gly Leu Ser Ala Arg 230 Leu Asp Leu i3 5 Arg Met Ser Leu Tyr 215 Ile Asp Pro 120 Ser G iu Ser Thr Ile 200 Met Val Leu Ser Gly Tyr Leu Gly 185 Giy Asn Trp Lys Val Ile Leu 170 Vai Ile Ala G iy Ser Giu Asn Phe Val 140 Asp Lys 155 Gly Leu His Ile Ser Giy Pro Aia 220 Leu Leu 235 Ser Leu Val1 125 Ser Gin Ala Pro Thr 205 Giy Phe G ly 110U C iy Leu Ala G ly Arg 190 Leu Ile C ly Val1 Leu Ala Val1 Met 175 Lys Giy Ile Leu Ala Val1 Tyr Ile 160 Phe Giu Gin Ala 240 Leu 250 Ala Leu Pro Ala Leu Ile Leu Cys Ser 260 Leu Lys Lys Ile 275 Giy Leu Leu Ile 255 Leu Lys Glu 270 a INFORMATION FOR SEQ ID NO:i540: Wi SEQUENCE CHARACTERISTICS: LENGTH: 269 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE:.
NAME/KEY: misc_feature LOCATION 1. .269 jxi) SEQUENCE DESCRIPTION: SEQ ID NO:1540 1Val Met Gin Leu Ser Pro Leu Gin Sen Ala Leu Leu Tyr Phe Arg Tyr a Phe Ile Ser Ser Gly Ile Pro Val Leu Ile Phe Giu Asp Gin Asn Lys Asn 130 Gly Tyr Ile Giu Ala Asn Met Asp 115 Leu Leu Pro Val1 Ile Trp Asp Phe 100 Ala Phe Leu G iu Met Ser Phe Leu Leu Leu Ala Ile Lys Val Ile Val1 70 Ala Phe Tyr Ile Ser Lys Phe .Ser 55 Lys Leu Tyr Val1 Leu 135 Tyr Thr Leu 40 Tyr Ile Arg Leu Val1 120 Leu Leu Arg 25 Val1 Asn Ala Leu Ile 105 Leu Ala 1-yr Ser Leu C iu Gin Pro 90 Gly Thr Lys Ile Phe Ala Ala Lys 75 Phe Arg Tyr Ser Lys Asp Leu Lys Ser Leu Lys Ala Val1 140 Thr Leu Giy Asp Val1 Ile Ile Leu 125 Leu Gin Ser Leu Phe Ala Ala Leu 110 Leu Val1 Lys Asp Leu Phe Ile His Lys Pro Leu Ile Leu Met Tyr Leu Val1 Lys C ly Ser Pro 1098 145 150 15516 Tyr Leu Thr Leu Ser Ala Cys Ala Phe Leu Asp Gly Ala Phe Ile Pro 165 170 175 Leu Leu Leu Gly Val Phe Ala Tyr Ala Leu Arg Lys Arg Tyr Phe Lys 180 185 190 Ser Ala Ile Phe Ala Leu Val Val Leu Ile Val Asn Thr Ala Leu Phe 195 200 205 Ser Gly Asp Phe Asn Lys Gly Leu Pro Ser Gly Tyr Phe Ile Asp Thr 210 215 220 Cys Leu Giu Leu Met Leu Leu Tyr Ser Pro Leu Leu Phe Leu Tyr Tyr 225 230 235 240 Pro Tyr Thr Leu Tyr Lys Ala Leu Leu Asp Lys Lys Pro Ser Leu Leu 245 250 255 Ala Phe Met Ala Arg Ala Ala Gly Phe Ser Leu Cys Phe 260 265 INFORMfATION FOR SEQ ID NO:1541: SEQUENCE CHARACTERISTICS: LENGTH: 241 amino acids TYPE: amino acid TOPOLOGY: linear iii) M~OLECULE TYPE: protein (iii) HYPOTHETICAL: YES ORIGINAL SOURCE: 00 ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .241 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1541 Sen Pro Phe Met Asp Arg Lys Leu Leu Arg Leu Tyr Gin Pro Leu Asn 1 5 10 Ala Tyr Ser Tyr Asn Ser Asp Sen Leu Phe Leu Tyr Asp Phe Sen Arg 25 Pro Phe Ile Lys Asn Sen Gly Ala Ile Leu Asp Ile Gly Sen Gly Cys 40 Gly Val Leu Gly Leu Leu Cys Ala Ang Asp Asn Pro Leu Ala Sen Val s0 55 His Leu Val Glu Lys Asp Ser Lys Met Ala Phe Cys Sen Gin Lys Asn 70 75 Ala Leu Lys Phe Pro Asn Ala Gin Val Phe Giu Ser Asp Phe Leu Asp 90 Phe Asn Pro Pro Ile Leu Tyr Asp Ala Ile Vai Cys Asn Pro Pro Phe 100 105 110 Tyr Ala.Leu Gly Ser Ile Lys Sen Gin Ile Lys Gly His Ala Ang His 115 120 125 Gin Sen Giu Leu Asp Phe Ala Ser Leu Val Ala Lys Val Lys Lys Cys 130 135 140 Leu Lys Pro Lys Gly Tyr Phe Ile Phe Cys Tyr Giu Ala Leu Ser Leu 145 150 155 160 Cys Leu Val Ile Giu Ser Leu Lys Ser Val Lys Leu Thr Leu Glu Thr 165 170 175 Leu Ang Phe Val Gin Ser Phe Lys Asp Lys Asn Ala His Leu Met Leu 180 185 190 Gly Ala Ala Arg Asa Asa Ser Lys Ser Ala Leu Lys Val Leu Pro Pro 195 200 205 Leu Ile Thr His Asn Sen Lys Asn Gin Ser Asp Asn Thr Lys Glu Val 210 215 220 1099 Leu Asn Ile Tyr Gin Ile Cys Asn Thr Tyr Ser Ile Lys Ala Pro Leu 225 230 235 240 Asp INFORMATION FOR SEQ ID NO:1542: SEQUENCE CHARACTERISTICS: LENGTH: 429 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...429 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i542 a. a.
a a..
Sen Arg Sen Phe Arg Gly Leu Leu Tyr Tyr Asn Lys Ile Asn Leu Ile 1 Asn I Leu Lys Gly' w Phe 4 Phe Gly Vai -Asn 145 His His Leu Sen Glu 225 Ile Leu Leu Ala Val .ys lal 67a Vral Gly Phe Gly Cys 130 Pro Gly Phe Val Lys 210 Gly Thr Leu Pro Let 29 Ili Asp Cys b Lys I Leu Leu Ile Lys 115 Gin Leu.
Thr Sen Ser 195 Tyr Val Ala Val Thr 275 Ser hr C 00 det I ?he I ral 31n Thr 100 Met Asn Met Ser Ser 180 Gly Lys Val Ser Gly 260 Phe Phe ly lal eu kla Phe Ile Leu Ala Gly Ala 165 Ser Gly Leu Ser Ser 245 Thr Val Phe Leu Gin C Leu Val I Arg Asp 55 Phe Phe 70 Asp Ser Gly Leu Ala Val Val Gly 135 Leu Leu 150 Ala Trp Leu Glu Ile Ile Glu Pro 215 Lys Gly 230 Phe Val Phe Leu Trp Cys Lys Ile 295 ;lu I eu I 10 I'yr2 Ile Sen Ser Phe 120 Ile Gly Ala Val Gly 200 Lys Phe Glu Ser Leu 280 Ele 55 eu ksp 4let Leu Ala 105 Leu Ser Gly Asn Gly 185 Gly Asp Glu Thr His 265 Phe 10 Lys Leu Ile Leu Lys 90 Asp Leu Ile Ser Phe 170 Met Pro Thr Thr Leu 250 Leu Val Leu ly Pro Ala 75 Asp Ptie Ala Ala Ile 155 Phe Ala Val Lys Pro 235 Ala Met Gly Asp Arg Glu Arg Pro Lys Val Sen 140 Ala Thr Cys Ala Glu 220 Lys Leu Pro Val Asp 300 Tie Tyr Pro Gln Leu Sen Ala 125 Leu Leu Gin Ala Lys 205 Lys Glu Ile Lys Ile 285 Arg Tyr Val Val Phe Met Leu 110 Gly Leu Val Pro Thr 190 Tyr Asp Gin Ala Ser 270 Leu Glu kla Tie Val Tyr Leu Gin Phe Gly Gly Pro 175 Phe Leu Thr Arg Ile 255 Phe Arg Val Thr Ser Gly His Thr Lys Vai Val Gly 160 Tyr Gly Ile Leu Leu 240 Ala Thr Asn Ser His Ser Val Phe Gly Asn Val Sen Leu Sen Leu Phe Leu Ala Tyr Ala Leu Met 1100 305 310 315 320 Ser Val Asn Leu Leu Glu Leu Leu Lys Leu Ala Val Pro Leu Ala Vai 325 330 335 Ile Leu Ser Val Gin Val Ala Val Met Ile Leu Tyr Val Val Leu Val 340 345 350 Thr Phe Arg Val Cys Gly Lys Asp Tyr Asp Ala Ala Val Leu Cys Ala 355 360 365 Gly His Cys Gly Phe Gly Leu Gly Ala Thr Pro Thr Ala Met Val Asn 370 375 380 Met Gin Thr Ile Thr Asn His Tyr Gly Pro Ser His Val Ala Phe Ile 385 390 395 400 Val Val Pro Leu Val Gly Ala Phe Phe Val Asp Ile Ile Asn Ala Leu 405 410 415 Ala Ile Lys Gly Phe Leu Leu Leu Pro Phe Phe Pro Ser 420 425 INFORMATION FOR SEQ ID NO:1543: SEQUENCE CHARACTERISTICS! (A LENGTH: 191 amino acids TYPE: amino acid TOPOLOGY: linear .000f.(ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAMAE/ KEY misc-feature LOCATION .191 (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1543 Lys Phe Val Leu Arg Ser Ile Ser Arg Ile Lys Met Leu Sen Val Tyr 1 5 10 Giu Lys Gly Asn Ala Leu Asp Lys Arg Val Leu Glu Glu Trp Leu Leu 25 Ser Giu Asp Ile Leu Met Giu Asn Ala Ala Met Ala Leu Giu Ang Ala 40 Val Leu Gin Asn Ala Ser Leu Gly Ala Lys Val Ile Ile Leu Cys Gly so* 5 55 Ser Gly Asp Asn. Gly Gly Asp Gly Tyr Thr Leu Ala Ang Arg Leu Val 70 75 Gly Arg Phe Lys Thr Leu Val Phe Glu Met Lys Leu Ala Lys Ser Pro 90 Met Cys Gin Leu Gin Lys Glu Arg Ala Lys Lys Val Gly Val Val Ile 100 105 110 Lys Ala Trp Giu Glu Lys-Asn Glu Asp Leu Glu Cys Asp Val Leu Val 115 120 125 Asp Cys Val Val Gly Ser Ala Phe Lys Gly Gly Leu Glu Pro Phe Leu 130 135 140 Asp Phe Giu Ser Leu Sen Gin Lys Ala Ang Phe Lys Ile Ala Cys Asp 145 150 155 160 Ile Pro Sen Gly Ile Asp Ser Lys Gly Arg Val Asp Lys Ang Ang Leu 165 170 175 Arg Arg Ile Arg Leu Ser Ala Trp Ala Leu Sen Ser His Ala Tyr 180 185 190 INFORMATION FOR SEQ ID NO:1544: 1101 SEQUENCE CHARACTERISTICS: LENGTH: 441 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .441 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1544 a a. Asn 1 Leu Leu Asp Pro Lys Gin Leu Thr Ala 145 Gly Ile Ala Arg kla rhr Leu Phe 50 Lys Gly Tyr Glu Arg 130 His Asp Asn Ser Tyr 210 Thr Ala Ser Thr Met Arg Ser 115 Lys 'Ser Sen His Val 195 Phe Pro Ile Lys Lys Ile Tyr 100 Leu Gin Asn Leu Leu 180 Tyr Pro 5 Lys C Asn I Pro *J Asp C Phe 85 Ala Lys Asp Ala Asn 165 Leu Phe Tyr Leu Phe 245 Ile Leu Gly Lys 7 Val 325 Met e Thr 1u ,eu hrI ;ln I 10 E'yr 1ln Ser Phe Leu 150 Lys Ala Leu Arg Gly 230 Leu Leu Leu Val Asp 310 Leu Phe Val .yr -yr jer .ys rhr Phe :ys Lys 135 Val Asp Ile Phe Asn 215 Tyr Met Sez Pro Tr 291 Se2 Va Sei Ph Ser Leu C 40 Leu Thr Thr Phe Phe 120 Ser Gly Leu Sen Ser 200 Ala Leu Gly Phe Lys 280 Tyr Ser 1 Phe r Pro e Phe 360 Crp 25 ;lu ksn Lyr Ile Gly 105 Phe His Asn Arg Gly 185 Leu Phe Leu Leu Lys 265 Le, Ile Phe Let Ty: 34' Pr 10 Cys C Tyr I Ala C Phe Lys 90 Lys Gin Leu Leu Asp 170 Phe Phe Tyr Leu I Leu 250 Leu Leu Phe Phe a Asn 330 r Gin o Leu ;ly .eu ;ln lal 75 -lu Ile Ihr Arg Tyr 155 Arq His Tyr Asp Leu 235 Gly Leu Phe Leu Lys 315 Met Leu Ser Val Asn Ile Leu Pro Lys Tyr His 140 Arg Ala Leu Thr Ile 220 Asp Phe Val Ser Phe 300 Arg Leu Phe Leu Val I His C Leu I Lys Leu Pro Ser 125 Phe Ala Asn Gly Pro 205 Gly Phe Leu Leu Va1 285 Leu Sen Ile Ser Phe 365 eu ;ln Leu Leu Lys :ys 110 Phe Ile Leu Ala Ile 190 Leu Va1 Leu Ala Ala 270 Gly Lys Phe Val Ile 350 Leu Ser I Lys I Gin Gln Asn Ser Ser Asp Phe Leu 175 Leu Gin Leu Pro Cys 255 Cys Phe His Gin Ala 335 Pro His eu Aeu lyr Ser Leu Phe Leu Ser Ile 160 Gly Ser Lys Val Ser 240 Phe Cys Leu Thr Ala 320 His Leu Ala His Asn Leu Lys Asp Lys Thr Phe Gin Gly Gly Phe Giu Leu Trp Val Phe Leu 225 Phe Phe Ile Leu Gin 305 Ile Ala Gly Phe Gly Ala Ser 290 Ile Ala Phe Leu Arg Val Ile 275 Val Phe Leu Phe Ile Ala Arg 260 Ala Cys Phe Sei Prc 34( Phe 355 Val Gly Leu Giy Ser Leu Leu Asp Asn Ile Leu Ser Met Pro Leu Thr
I
1102 370 375 380 Ile Pro Thr Ile Ser Val Ser Ser Pro Leu Trp Leu Leu Gly Ala His 385 390 395 400 Leu Phe Leu Thr Ile Leu Ser Val Arg Phe Phe Lys Val Tyr Leu Ser 405 410 415 Met Asn Val Leu Ser Met Gly Phe Phe Leu Tyr Cys Cys Tyr Gln Tyr 420 425 430 Ile Ile Met Pro Ser Leu Ile Val Gly 435 440 INFORMATION FOR SEQ ID NO:1545: SEQUENCE CHARACTERISTICS: LENGTH: 302 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...302 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1545 Glu Ala Phe Lys Ala Asp Thr Thr Ile Ser Met Gly Ala Ile Lys Ser 1 5 10 Cys Leu Leu Ser Asp Lys Ala Lys Asp Tyr Ile Gly Glu Leu Lys Val 25 Gly His Leu Gly Val Phe Asn Gln Ile Tyr Glu Ile Pro Thr Asp Thr 35 40 Phe Leu Leu Glu Lys Ser Asp Leu Lys Leu Pro Leu Arg Asp Arg Lys 55 Asn Ala His Lys Gly Asp Tyr Gly His Ala His Val Leu Leu Gly Lys 65 70 75 His Ser Gly Ala Gly Leu Leu Ser Ala Leu Ser Ala Leu Ser Phe Gly 85 90 Ser Gly Val Val Ser Ile Gin Ala Leu Glu Cys Glu Ile Thr Ser Asn 100 105 110 Asn Lys Pro Leu Glu Leu Val Phe Cys Glu Asn Phe Pro Lys Lys Leu 115 120 125 Ser Ala Phe Ala Leu Gly Met Gly Leu Glu Asn Ile Pro Lys Asp Phe 130 135 140 Lys Lys Trp Leu Glu Leu Ala Pro Cys Val Leu Asp Ala Gly Val Phe 145 150 155 160 Tyr His Lys Glu Val Leu Gln Ala Leu Glu Lys Glu Val Ile Leu Thr 165 170 175 Pro His Pro Lys Glu Phe Leu Ser Leu Leu Lys Ser Val Gly Ile Asn 180 185 190 Ile Ser Met Leu Glu Leu Leu Asp Asn Lys Leu Glu Ile Ala Arg Asp 195 200 205 Phe Ser Gin Lys Tyr Pro Lys Val Val Leu Leu Leu Lys Gly Ala Asn 210 215 220 Thr Leu Ile Ala His Gin Gly Arg Val Phe Ile Asn Asn Leu Gly Ser 225 230 235 240 Val Ala Leu Ala Lys Ala Gly Ser Gly Asp Val Leu Ala Gly Leu Ile 245 250 255 Val Ser Leu Leu Ser Gin Asn Tyr Thr Pro Leu Asp Ala Ala Ile Asn 260 265 270 1103 Ala Ser Leu Ala His Ala Leu Ala Gly Leu Glu Phe Lys Asn His Tyr 275 280 285 Ala Leu Thr Pro Leu Asp Leu Ile Glu Lys Ile Lys Arg Leu 290 295 300 INFORMATION FOR SEQ ID NO:1546: SEQUENCE CHARACTERISTICS: LENGTH: 375 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...375 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1546 *e e
S.
S
OSS*
5)S* S. S
S
Leu 1 Thr Thr Lys Leu Asn Trp Glu Phe Asp 145 Gly Lys Asn Asn Glu 225 Pro Leu Asp Lys Ala Met Asn Ile Gly Phe Leu Ile Arg 130 Arg Ile Asn Glu Leu 210 Phe Leu Ile Tyr Ser Leu Thr Pro Thr Leu Gly Arg 115 Leu Trp Asn Leu Asn 195 Gin Leu Pro Ile Cys 275 Val Ala Pro Arg Ser Glu Phe 100 Arg Gly Phe Ser Gly 180 Leu Ile Ser Pro Gly 260 Cys Met 5 Val Ala Phe Met Ala Glu Pro Val Leu Ser 165 Phe Glu Ala Leu Ile 245 Ser Val Leu Gly Ser Ala Lys 70 Leu Ser Asn Ser Ser 150 Val Ser Val Pro Thr 230 Gly Gly His Asn Phe Phe Phe 55 Ser Gin Leu Pro Val 135 Gin Leu Asp Ser His 215 Pro Asn Pro Ala Cys 295 Ser Glu 40 Glu Ile Lys Ser Lys 120 Asp Ile Thr Ala Pro 200 Phe Tyr Lys Asn Ser 280 Asn Leu 25 Pro Lys Gly Ala Lys 105 Arg Glu Gin Asp Arg 185 Phe Glu Leu Gin Arg 265 Phe Pro 10 Asp Ser Phe Glu Leu 90 Asp Leu Val Lys Ala 170 Ile Glu Glu Tyr Glu 250 Ile Ala Glu Glu Leu Ala Val 75 Cys Leu Leu Phe Leu 155 Lys Ala Val Val Ser 235 Lys Gly Leu Thr Ile Asp Gly Met Ser Glu Tyr Glu 140 Val Lys Thr Glu Asp 220 Thr Gin Gin Lys Val Lys Asn Tyr Ile Val Ser Ala Ile Leu Glu Ala Ile 110 Ile Ala 125 Leu Cys Lys Ala Leu Arg Lys Ile 190 Leu Ala 205 Thr Cys Tyr Ala Glu Lys Gly Ile 270 Asp Leu 285 Ser Thr Asp Val Ser Gly Asn Lys Asp Gin Glu Gly 175 Lys Arg Ala Pro Lys 255 Glu Asn Asp Ile Val Thr Gly Asn Lys Ala Ile Glu 160 Leu Glu Ser Ala Asn 240 Ile Phe Ile Tyr Leu Ala Ser Lys Ala Thr Gly Phe Pro Ile Ala Lys Val Ala 290 300 Asp Thr Ser Asp Thr Leu Tyr Phe Glu Pro Ile His Phe Glu Cys Val 1104 305 310 315 320 Lys Ser Ile Ile Gin Arg Glu Arg Val Asp Gly Ile Ile Val His Phe 325 330 335 Gly Gly Gin Thr Pro Leu Lys Leu Ala Lys Asp Leu Ala Lys Met Gin 340 345 350 Ala Pro Ile Ile Gly Thr Pro Phe Lys Val Ile Asp Ile Ala Glu Asp 355 360 365 Arg Glu Lys Phe Pro Ser Phe 370 375 INFORMATION FOR SEQ ID NO:1547: SEQUENCE CHARACTERISTICS: LENGTH: 152 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori S(ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...152 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1547 Arg Pro Val Ile Ser Ala Lys Glu Gly Ser Asp Pro Ser Ser Leu Ala 1 5 10 Tyr Asn Thr Ile Glu Ser Ala Ile Ala Lys Asn Ile Asp Glu Val Phe 25 Ile Asp Thr Ala Gly Arg Leu His Asn Gin Thr Asn Leu Lys Asn Glu 40 Leu Ser Lys Ile Ala His Thr Cys Ser Lys Val Leu Lys Asp Ala Pro 55 Phe Tyr Lys Phe Leu Ile Leu Asp Gly Thr Girl Gly Ser Ser Gly Leu 65 70 75 Thr Gin Ala Lys Ile Phe His Glu Thr Leu Ala Leu Asp Gly Val Ile 85 90 Met Thr Lys Leu Asp Gly Thr Ser Lys Gly Gly Ala Ile Leu Ser Val 100 105 110 Leu Tyr Glu Leu Lys Leu Pro Ile Leu Tyr Leu Gly Met Gly Glu Lys 115 120 125 Glu Asp Asp Leu Ile Ala Phe Asp Glu Glu Arg Phe Ile Glu Asp Leu 130 135 140 Val Asp Ala Val Phe Val Glu Gin 145 150 INFORMATION FOR SEQ ID NO:1548: SEQUENCE CHARACTERISTICS: LENGTH: 231 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: 1105 ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...231 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1548 Asn Leu Arg Ile Ile Thr Ile Lys Thr Ile Phe Arg Asp Phe Cys Lys 1 5 10 Glu Arg Leu Lys Arg Ala Lys Ser Lys Asn Lys Val Arg Asp Lys Leu 25 Ala Cys Lys Leu Leu Phe Trp Lys Leu Lys Asp Tyr Gin Asn Ile Leu 40 Leu Tyr Ser Pro Leu Gly His Glu Leu Asp Ile Arg Pro Leu Ile Leu 55 Lys Leu Arg Gin Lys Asn Lys Arg Val Trp Leu Pro Lys Ser Ile Lys 70 75 Lys Gly Ala His Phe Ser Lys Glu Gly Phe Thr Ile Ala Pro Phe Arg 90 Leu Pro Leu Arg Arg Leu Gly Trp Phe Asp Glu Pro Ser Leu Ser Arg 100 105 110 Tyr Tyr Lys Arg Glu Leu Asp Cys Ile Val Val Pro Ile Leu Gly Met 115 120 125 Asp Thr Ser Phe Arg Arg Val Gly Phe Gly Leu Gly Met Tyr Asp Arg 130 135 140 Ser Leu Pro Gin Leu Phe Lys Lys Gin Leu Lys Arg Pro Leu Val Ile 145 150 155 160 Phe Val Ser Arg Glu Leu Ala Leu Ala Asn Gly Ile Leu Thr Asp Ala 165 170 175 Tyr Asp Ile Glu Ala Asn Leu Tyr Met Asn Ala Arg Ile Val Met Lys 180 185 190 S* Asn Asn Lys Arg Lys His Tyr Glu Gin Arg Val Asn Leu His Phe Ile 195 200 205 Arg Ser Leu Gly Ser Val Phe Asp His Arg Ser Asn His Val Leu Cys 210 215 220 Asp Glu Lys Asp Leu Leu Arg 225 230 INFORMATION FOR SEQ ID NO:1549: SEQUENCE CHARACTERISTICS: LENGTH: 200 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...200 (xi) SEQUENCE DESCRIPTION: SEQ ID N0:1549 Arg Ile Ile Lys Gly Asn Ile Met Ser Ser Gly Leu Ile Tyr Ile Ser 1 5 10 Leu Glu Val Leu Val Ala Cys Leu Ile Thr Ala Leu Ile Met Tyr Tyr 25 Val Met Lys Lys Ile Tyr Tyr Ala Arg Gly Gln Ala Ile Leu Lys Gly I I 1106 40 Ala Ser Ala Lys Ala Lys Leu Met Glu Phe Gin Ala Lys Ser Phe Val 55 Glu Ala Glu Glu Met Arg Met Lys Ser Gin Glu Cys Lys Leu Gin Gin 70 75 Gin Tyr Glu Asn Lys Asn Leu Gin Leu Gin Thr His Phe Asp Lys Lys 90 Glu Ala His Leu Lys His Leu Glu Ala Gin His Lys Glu Phe Val Arg 100 105 110 Asp Glu Lys Arg Tyr Leu Glu Lys Glu Lys Lys Glu Leu Glu Lys Glu 115 120 125 Arg Gin Ile Leu Glu Gin Glu Arg Glu Asn Phe Lys Lys Gin Arg Ala 130 135 140 Ile Cys Lys Glu Ala Gin Ala Lys Ala Leu Asp Ala Met Leu Asn Tyr 145 150 155 160 Met Ala Tyr Thr Lys Asp Glu Ile Lys Ser Met Ile Leu Glu Gin Leu 165 170 175 Glu Gin Glu Leu Glu Ala Gin Lys Ser Ala Leu Ile Arg Arg Tyr Glu 180 185 190 Glu Glu Ala Phe Ile Met Cys Leu 195 200 INFORMATION FOR SEQ ID NO:1550: SEQUENCE CHARACTERISTICS: LENGTH: 350 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...350 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1550 Ile Arg Ser Ser Asn Asp Thr Gin Thr Thr Gin Thr Pro Trp His Ser 1 5 10 Asn Thr Arg Arg Pro Lys Pro Thr Pro Lys Pro Ile Lys Lys Glu Ala 25 Lys Lys Ala Lys Glu Lys Thr Thr Lys His Ala His Ser Lys His Ala 40 His Ser Pro Leu Asn Glu Arg Ser Ala Lys Lys Glu Ile Pro Lys Lys 55 Glu Ile Pro Lys Lys Glu Ile Pro Lys Lys Glu Ile Pro Lys Lys Glu 70 75 Ile Pro Lys Lys Glu Ile Pro Lys Lys Glu Ile Pro Lys Lys Glu Ile 90 Pro Lys Lys Glu Ala Glu Asn Glu Ser Lys Asn Gin Ile Phe Ile Ala 100 105 110 Glu Lys Asn Asp Thr Trp Ile Lys Thr Lys Arg Lys Lys His Lys Lys 115 120 125 Ile Val Leu Asp Ala Gly His Gly Gly Lys Asp Cys Gly Ala Met Ser 130 135 140 Ala Asn Leu Val Cys Glu Lys Asp Ile Val Leu Glu Val Val Lys Phe 145 150 155 160 Leu His Lys Glu Leu Lys Lys Arg Gly Tyr Ser Val Leu Leu Thr Arg 165 170 175 1107 Asp Lys Asp Ile Tyr Ile Asp Leu Val Ala Arg Thr Giu Leu Ala Asn Lys Lys Thr 225 Asp Ser Val Val Leu 305 Giu Gly Lys Arg 210 Ala Asp Leu Gin Asp 290 Met Ser Ile Ser Phe Glu Phe Ala 270 Pro Ala His Leu Asp 350 Ile Leu As n Leu 255 Ile Asp Gly Ala Ala 335 INFORMATION FOR SEQ ID NO:1551: SEQUENCE CHARACTERISTICS: LENGTH: 186 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .186 (xi) SEQUENCE DESCRIPTION: SEQ ID N0:1551 Arg Val Sen Met Asn Val Lys Lys Lys Gly Lys Pro 1 Ile Phe Ile Sen Leu Ile Ang Leu Asn 145 Lys Ang Sen Gly Thr Ang Gin Phe 115 Arg Lys G lu Val1 Ser Val1 Phe Gin Leu 100 His Ala I le Cys 5 Asp Ile Gly Tyr Arg Glu G ly Leu Gin Tnp Leu Met Leu Val Ile Ile Ala 135 Gly Phe Glu Gly 40 Ile Sen Glu Gin Lys 120 Gly Met Ile Lys 25 Ser Gly Leu Ile Asn 105 Phe Asp G ly Thr Gin Giu Leu Gly Lys Cys Glu Sen 125 Ala Leu Glu Sen Asn Ala G ly Glu Ang Val1 110 Phe Ile Phe G ly Gly is Thr Ile Vali Ala Giu Phe Asp Ala Asp Trp 1108 165 170 Phe Val Thr Ser Arg Gly Lys Thr Glu Ile 180 185 INFORMATION FOR SEQ ID NO:1552: SEQUENCE CHARACTERISTICS: LENGTH: 362 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Melicobacter pylori (ix) FE.ATURE: NAME/KEY: misc-feature LOCATION .362 (xi) SEQUENCE DESCRIPTION: SEQ ID N0:1552 Lys Lys Giu Val Val 65 Leu Leu Gly Asn Asp 145 Phe Leu Leu Leu Gin 225 Lys Met Tyr Val1 Arg 305 Arg Lys Val Phe so Leu Phe Ile Trp Pro 130 Gly Phe Asn Ile Ile 210 Giu Ala Gin Ala Ala 290 Asp Gin Met Ala Giu Glu Giu Ile VJal 35 Phe L~ys Asn Ile Leu 115 Ile Ser Ile Leu Sen 195 Ile Val Lys Glu Val1 275 Lys Gin 20 Gly Ile Asp Gin Leu 100 Phe Asn Leu Phe Gin 180 Ser Lys Lys Ile Ile 260 Ala Gly Ala Leu Trp Ser 70 Ala Val1 Pro Val Thr 150 Leu Gin Leu Ang Glu 230 Gin Lys Lys Asp Arg Gly Val 55 Leu
LYS
Val Lys Lys 135 Leu Phe Leu Phe qin 215 Tyr Met Ser Phe Tyr 295 Glu Leu 40 Asp Asp Asp Ala Val 120 Asn Lys Leu Leu Leu 200 Tyr Lys Met Asn Asp 280 Leu Giu 25 Leu Gly Phe Thr Phe 105 Ile Leu Val Gly Trp, 185 Phe Thn Gin Val Val1 265 Giu Ala Lys Thn Glu Gly Asn Val Ala Gly Leu ?he Sen Giu Ser Lys Giu 75 Phe Leu Leu 90 Leu Ser Asn Giu Pro Lys Phe Ser Leu 140 Phe Leu Ala 155 Glu Leu Asn 170 Phe Lys Sen Phe Val Leu Asn Ser Leu 220 Gin Giu Gly 235 Lys Asn Ala 250 Val Vai Thr Giu His Pro Ile Arg Ile 300 Asn Lys Thn 315 Leu Pro Met Met Sen Leu Val Phe 125 Lys Phe His Lys Ala 205 Lys Asn Thr Asn Val1 285 Lys Pro Lys Ser Tyr Val Leu Leu 110 Ser Lys Phe Ala Ala 190 Phe Met Pro Asn Pro 270 Pro Gly Ser Ser Ile Arg Gin Pro Gin Lys Ile Leu Ala 175 Leu Val Thn Giu Lys 255 Thr Val1 Ile Ala Met Phe His Giu Val1 Phe Ile Leu Gly 160 Leu Tnp Asp Lys Ile 240 Met His Val1 Ala Glu 320 Glu His Asp Ile Gu Ile Ile Giu 310 Leu Ala Arg 1109 Leu Tyr Arg Asp Val Lys Leu Asn Ala Thr Ile Pro Glu Glu Leu Phe 325 330 335 Glu Ala Val Ala Ile Val Phe Ala Gln Val Ala Lys Leu Glu Gln Glu 340 345 350 Arg Gin Lys Gln Lys Ile Ile Lys Pro Leu 355 360 INFORMATION FOR SEQ ID NO:1553: SEQUENCE CHARACTERISTICS: LENGTH: 181 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...181 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1553 Glu Asn Thr Met Gin Asp Leu Gin His Phe Lys Asn Asp Ile Thr Leu S1 5 10 Ile Leu Ser Lys Asp Arg Leu Asp Thr Tyr Asp Ser Leu Glu Gin Tyr 20 25 Lys Glu Asn Leu Lys Leu Ile Ser Phe Ile Thr Pro Lys Ile Ser Asn 40 Leu Glu Ile Tyr Leu Arg Asn Ala Leu Asp Tyr Cys Leu Thr Gin Ile 50 55 Lys Gly Ser Glu Trp Val Phe Asn Glu Asn Ser Leu Thr Asp Leu Ile 70 75 Asn Glu Gin Lys Glu Lys Lys Lys Glu Ile Thy His Ser Leu Ile Leu 85 90 Ser Lys Met Ser Leu Gly Ala Val Val Arg Leu Ile Phe Cys Tyr Lys 100 105 110 Leu Glu Gly Val Ile Leu Asp Leu Arg Ala Tyr Arg Leu Arg Ala Tyr 115 120 125 S. Tyr His Glu Asn Lys Asp Thr Leu Leu Ile Lys Gly Lys Lys Arg Leu 130 135 140 Leu Tyr Asn Tyr Ile Lys Ala His Ile Ala Leu Asn Leu Leu Trp Thr 145 150 155 160 Ile Arg Asn Arg Thr Tyr His Trp Glu Asn Leu Leu Lys Ile Gin Pro 165 170 175 Asn Asn Arg Pro Gin 180 INFORMATION FOR SEQ ID NO:1554: SEQUENCE CHARACTERISTICS: LENGTH: 189 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES 1110 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc feature LOCATION 189 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1554 Ala Asn Gly Cys Glu Lys Arg Ile Phe Met Leu Leu Cys Ala Gly Arg 1 5 10 Asn Glu Thr Leu Lys Lys Ala Val Pro Ile Gly Val Gly Leu Ile Giu 25 Ser Ala Ile Asn Leu Thr Arg Met Cys Leu Lys Asn Pro Asp Thr Giu 40 Ser Leu Ile Phe Ile Gly Ser Ala Gly Ser Tyr Ser Pro Giu Thr Giu 55 Ile Leu Sen Val Phe Giu Sen Ile Giu Gly Tyr Gin Ile Glu Glu Ser 70 75 Phe Ser His Leu Asn Ser Tyr Thn Pro Leu Asp Asn Phe Ile His Ile 90 Glu Thr Lys Giu Gin Ala Leu Phe Giu Arg Val Arg Val Asn Sen Ser 100 105 110 Asn Tyr Ile His Thr Ser Glu Met Phe Ala Lys Lys Met Val Gin Lys 115 120 125 Gly Val Leu Leu Glu Asn Met Giu Phe Phe Sen Val Leu Sen Val Ala *130 135 140 Lys Ile Phe Ser Leu Lys Ala Lys Gly Ile Phe Cys Val Ser Asn His 145 150 155 160 Val Gly Leu Asn Ala His Lys Glu Phe Lys Giu Asn His Ala Lys Val Gi ieLu165 170 175 Lys GnIeLuGlu Asn Ile Ile Asp Ser Leu Ile Val 185 0* INFORMATION FOR SEQ ID NO:.1555: Wi SEQUENCE CHARACTERISTICS: LENGTH: 293 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein 0 (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: N)AIE/KEY: misc..feature LOCATION .293 (xi) SEQ UEN CE DESCRIPTION: SEQ ID NO:l555 Phe Vai Leu Ala Cys Asn Arg Leu Leu Ala Ang Thr Leu Lys Ser Glu 1 5 10 Tyr Arg Ile Cys Gly Phe Ala Lys Asn His Pro Phe Sen Gly Pro Phe 25 Giu Ser Gly Gly Val Trp Phe Cys Gly Tyr Sen Thn Phe Arg Leu Asn 40 Ang Phe Sen Gly His Tyr Cys Cys Lys Tnp Arg Arg Asn Gly Ile Gin s0 55 Ser Val Val Asp Glu Thn Lys Pro Phe Thn His Sen Lys Asn Gly Arg 1-70 75 1111 Lys Arg Gly Phe Ser Leu Phe Gin Ala Ile Gin Pro Ser Val Phe Asp 90 Arg Ser Thr Leu Ala Asn Gin Ser Asp His Arg Tyr Phe His Leu Phe 100 105 110 Val Gly Tyr Phe Phe Glu Trp Val Pro Lys Asn Arg Phe Lys Glu Ser 115 120 125 Val Gin Cys Leu Arg Gly Gly Asp Leu Tyr Cys Asn His Gin His Ala 130 135 140 Gin Tyr Phe Lys Leu Glu Phe Asn Phe Arg Lys Lys Arg Ala Gly Tyr 145 150 155 160 Lys Arg Arg Tyr Asn Phe His Ala Val Phe Phe Gly Gly His Cys Arg 165 170 175 His Ala Arg Glu Thr Phe Phe Arg Gin Ser Ile Lys Leu Leu Arg Leu 180 185 190 Leu Arg Phe Ser Glu Lys Arg Lys Thr Lys Arg Ser Lys Asp Lys Glu 195 200 205 Arg Arg Lys Asp Cys Arg Lys Thr Arg Asn Gin Ala Arg Ser His Arg 210 215 220 Ala Lys Ser Gin Ser Arg His Arg Lys Arg Ser His Phe Arg Arg Glu 225 230 235 240 Lys Leu Pro Lys Ser Arg Ala Lys Ile Arg Arg Arg Lys Ala Ser Phe 245 250 255 Lys Arg Lys Glu Lys Asn Ser His Gin Lys Gly Tyr Gly Ile Thr Lys 260 265 270 Ser Glu Arg Thr Ser Arg Lys Arg Lys Arg Ala Arg Lys Lys Lys Ser 4 275 280 285 Phe Arg Asn Glu Glu S290 INFORMATION FOR SEQ ID NO:1556: SEQUENCE CHARACTERISTICS: LENGTH: 284 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...284 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1556 Gly Glu Thr Thr Met Lys Leu Arg Ala Ser Val Leu Ile Gly Val Ala 1 5 10 Ile Leu Cys Leu Ile Leu Ser Ala Cys Ser Asn Tyr Ala Lys Lys Val 25 Val Lys Gin Lys Asn His Val Tyr Thr Pro Val Tyr Asn Glu Leu Ile 40 Glu Lys Tyr Ser Glu Ile Pro Leu Asn Asp Lys Leu Lys Asp Thr Pro 55 Phe Met Val Gin Val Lys Leu Pro Asn Tyr Lys Asp Tyr Leu Leu Asp 70 75 Asn Lys Gin Val Val Leu Thr Phe Lys Leu Val His His Ser Lys Lys 90 Ile Thr Leu Ile Gly Asp Ala Asn Lys Ile Leu Gin Tyr Lys Asn Tyr 100 105 110 Phe Gin Ala Asn Gly:Ala Arg Ser Asp Ile Asp Phe Tyr Leu Gin Pro 1112 Thr Asn 145 Ser Val
LYS
Asp Leu 225 lie Glu Leu 115 Leu Azn 130 Pro Asn Gin Pro Ser Gly Ala Gin 195 Lys Glu 210 Giu Thr Ser Ser Giu Glu Arg Asn .275 Gin Asm Met Ala 180 Leu Gin Leu Giu Val 260 Gin Val1 135 Lys Ala Lys Ile Thr 215 Arg Lys Lys Ser 120 Val1 Pro Asn Gin Asn 200 Thr Ala Asn Leu Lou 280 Met Gin Thr Val1 185 Gin Arg Gly Gly Gin 265 Leu Ala Phe 155 Asn Asn Tyr Asn Gin 235 Leu Giu Gly So r 140 Asp Leu Giu Lys Asn 220 Met Asn Arg Lys 125 As n Val1 His Val1 Thr 205 Gin Arg Met Giu Tyr Leu Gly Ala 190 Leu Arg Gin Gin As n 270 *0 INFORMATION FOR SEQ ID NO:1557: SEQUENCE CHARACTERISTICS: LENGTH: 241 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOT HET ICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .241 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:15S7 Ser Lou Gin Leu Gly Gly Phe Lou Giu Gly 145 Glu Tyr Cys Gin Met Lys Thr Leu Val Ala Glu Thr Ile Ala Phe Ile 120 Asp Glu Gin Glu 25 Thr Ser Lys Asn Lys 105 Asn Lys Lys Se r Lys Asp Asn Pro Lys Phe Thr Pro Val Gin Asn 170 Asn Thr Ile Ile Thr Ser Gin Gin Val Ser Ala Asn Ala Ala Ile Glu Ala Asn Tyr Met Sen Leu Asp Gin 125 Lou Val Leu 140 Asn I2e Arg 155 Ile Giy Giy Tyr G ly Lou Asn Ala Glu Ser 110 Lys Tyr Glu Thr Ser Leu Lys Lys Lou Lou Pro Thr Cys Arg Ala 175 1113 Leu Ile Thr Ala Ser Gin Thr Leu Val Glu Ser Leu Lys Asn Lys Asn 180 185 190 Phe Ile Lys Gly Ile Lys Lys Leu Met Leu Ala His Asn Lys Val Phe 195 200 205 Leu Asn Tyr Leu Giu Giu Leu Asp Ala Leu Giu Arg Ser Leu Glu Gin 210 215 220 Ser Lys Arg Gin Tyr Leu Gin Glu Arg Gin Ser Ser Lys Ile Ile Val 225 230 235 240
LYS
INFOMTION FOR SEQ ID N'O:i558: SEQUENCE CHARACTERISTICS: LENGTH: 539 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION i .539 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1558 Ile Asn Lys Asn Met Phe Asn Ile Lys Arg Thr Phe Leu Ile Thr Ile 1 5 10 Sle Ser Phe Phe Leu Ile Val Pro Asn Trp Leu Lys Ala Ile Asp Leu Pr ieVl20 25 Pr l a Ser Asn Leu Lys Ile Tyr Gin Thr Vai Tyr Cys Met Leu 40 Ile Pro Ser Tyr Val Leu Thr Asn Lys Sen Phe.Ala Asp Ile Leu Thr 55 *Gly Tyr Thr Sen Ile Gly Ala Sen Gly Ser Gly Lys Ser Sen Gly Gin 70 75 Gly Val Ile Giu Ala Leu Ser Thr Pro Leu Ala Thr Ser Leu Ala Ala 90 Sen Asn Leu Val Lys Tyr Leu Asn Thr Leu Gly Pro Leu Trp Gly Ser 100 105 110 Ala Txp Ala Sen Val Ala Thr Ala Ile Gin Gly Phe Ala Leu Thr Pro 11.5 120 125 Ser Ser Gly Cys Asn Phe Gly Trp Asn Ala Leu Ile Asn Lys Asn Ile 130 135 140 Asp Val Ser Met Asp Sen Val Leu Asp Asn Leu Ser Asn Lys Ile Gin 145 150 155 160 Asn Phe Tbr Lys Gly Gly Val Giu Asp Asn Val Lys Gly Asn Ile Leu 165 170 175 Leu Gin Ile Ile Giy Sen Ile Thr Ala Gin Ala Ser Thr Asn Ile Thr 180 185 190 Ala Asp Gly Leu Ile Tnp Leu Ile Gly Lys Giu Phe Thr Ala Asn Lys 195 200 205 Leu Gin Asn Asn Thr Ile Ala Met Leu Ala Phe Ala Ala Leu Giu Ser 210 215 220 Val Val Lys Gly Ala Asp Ala Ala Val Leu Pro Ala Tyr Gly Val Val 225 230 235 240 Asn Leu Pro Asp Ile Ile Ile Giy Gin Gly Ser Tyr Leu Asp Phe Val 245 250 255 Ser Tyr Leu Ile Tyr ,le Val Phe Gly Ile Phe Val Phe Ile Ser Phe 1114 260 265 270 Met Lys Leu Arg Asp Ile Ser Asn Gly Ile Gin Ile Asn Ile Gly Phe 275 280 285 Glu Tyr Met Arg Phe Val Gly Gly Thr Leu Phe Lys Met Ala Met Val 290 295 300 Ser Phe Ile Ala Tyr Ala Gly Phe Gly Tyr Leu Tyr Lys Ile Ser Tyr 305 310 315 320 Ser Ile Tyr Phe Gly Leu Ala Gly Ala Phe Gly Leu Asn Gin Val Leu 325 330 335 Phe Trp Ala Leu Asp Leu Val Leu Asn Tyr Thr Val Asn Ser Ile Leu 340 345 350 Pro Ala Val Arg Ala Val Phe Ser Asn Val Gly Asn Asn Ala Pro Ser 355 360 365 Leu Leu Gin Gly Leu Gin Val Ala Gly Ile Ser Leu Phe Ala Ile Phe 370 375 380 Met Gin Val Thr Ile Ile Met Arg Ile Ser Thr Val Val Val Lys Pro 385 390 395 400 Leu Ile Ala Gly Ala Phe Ser Gly Ile Val Phe Pro Ile Ala Val Cys 405 410 415 Leu Ile Val Leu Asp Trp Phe Lys Asp Ser Met Lys Asn Ile Leu Ile 420 425 430 Trp Phe Ile Asn Asn Leu Phe Ile Leu Val Leu Ala Ile Pro Ile Leu 435 440 445 Leu Phe Gly Val Leu Ala Leu Leu Ala Phe Asn Leu Thr Ile Thr Pro 450 455 460 Ser Val Ala Ile Gin Asn Ile Asn Gin Gly Gly Leu Gly Ile Asp Ser 465 470 475 480 S Thr Ile Ala Ser Leu Ile Thr Leu Phe Ile Leu Lys Gly Phe Ile Glu 485 490 495 Thr Ile Ile Glu Ser Val Asn Ala Ile Val Asn Thr Ile Phe Ser Ser 500 505 510 SVal Ser Met Asp Gly Ser Arg Met Asp Arg Glu Arg Asp Ala Leu Met 515 520 525 Val Gly Arg Val Gly Gly Ser Met Phe Lys Gly 530 535 INFORMATION FOR SEQ ID NO:1559: SEQUENCE CHARACTERISTICS: LENGTH: 256 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...256 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1559 Leu His Arg Ile Ile Ser Cys Asp Ser Ala Trp Arg Thr Asn Leu Val 1 5 10 Val Arg Thr Asn Lys Ala Leu Tyr Gin Phe Ile Leu Arg Ile Ala Gin 25 Lys Asp Asn Phe Ala Ser Ala Tyr Leu Thr Val Lys Leu Glu Tyr Pro 40 Gln Arg His Glu Val Ser Ser Val Ile Glu Glu Glu Leu Lys Lys Arg 55 1115 Giu Giu Ala Lys Arg Gin Arg Giu Leu Ile Lys Gin Giu Asn Leu Asn 70 75 so Thr Thr Ala Tyr Ile Asn Arg Vai Met Met Ala Ser Asn Giu Gin Ile 90 Ile Asn Lys Giu Lys Ile Arg Giu Giu Lys Gin Lys Ile Ile Leu Asp 100 105 110 Gin Ala Lys Ala Leu Giu Thr Gin Tyr Val His Asn Ala Leu Lys Arg 115 120 125 Asn Pro Val Pro Arg Asn Tyr Asn Tyr Tyr Gin Ala Pro Glu Lys Arg 130 135 140 Ser Lys His Ile Met Pro Ser Giu Ile Phe Asp Asp Gly Thr Phe Thr 145 150 155 160 Tyr Phe Gly Phe Lys Asn Ile Thr Leu Gin Pro Ala Ile Phe Val Val 165 170 175 Gin Pro Asp Gly Lys Leu Ser Met Thr Asp Ala Ala Ile Asp Pro Asn 180 185 190 Met Thr Asn Ser Gly Leu Arg Trp Tyr Arg Vai Asn Giu Ile Ala Giu .195200 205 Lys Phe Lys Leu Ile Lys Asp Lys Ala Leu Val Thr Vai Ile Asn Lys 210 215 220 Gly Tyr Gly Lys Asn Pro Leu Thr Lys Asn Tyr Asn Ile Lys Asn Tyr 225 230 235 240 Gly Giu Leu Giu Arg Val Ile Lys Lys Leu Pro Leu Val Arg Asp Lys 245 250 255 INFORMATION FOR SEQ ID NO:i560: ()SEQUENCE CHARACTERISTICS: LENGTH: 121 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein *(iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori.
(ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 121 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1560 Thr Ser Sen Phe Lys Thr Lys Met Lys Arg Pro Ile Ser Lys Leu Lys 1 5 10 Gin Asn Phe Leu Gin Phe Lys His Ser Phe Asn Lys His Leu Asp Lys 25 Tyr Sen Leu Tyr Tyr Ang Leu Phe Asn Ile Sen Sen Ile Val Ile Gly 40 Phe Leu Ile Ala Leu Phe Ser Tyr Gly Ala Gly Val Ile Leu Val Tyr 55 Pro Ile Leu Phe Leu Phe Ala Leu Ile Ile Lys Pro Sen Phe Phe Tyr 70 75 Tyr Thr Thr Tyr Leu Leu Leu Leu Val Ser Leu Ser Ile Ile Ser Lys 90 Tyr Tyn Leu Leu Sen His Ala Asn Phe Thr Met Lys Leu Ile Met Leu 100 105 110 Met Thr Gin Trp, Gin Asn Trp Phe Leu 115 120 INFORMATION FOR, SEQ ID NO:1561: 1116 SEQUENCE CHARACTERISTICS: LENGTH: 131 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOChTION .131 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1561 Val Cys Tyr Cys Glu Met Leu Pro Thr Lys Thr Arg Ile Arg Asp Pro 1 5 10 Asn Lys Gin Giu Leu Thr Gin Pro Lys Ile Lys Gly Leu Ser Met dly 25 Lys Ile Leu Aia Ser Leu Leu Gly Gly Gly Thr Asn Leu Phe Thr Gly 40 :0 Leu Ser Ser Asp Leu Phe Ser Met Ile Leu Asn Phe Leu Phe Phe Leu Met Leu Met Met Gly Leu Asn Glu' Ala Leu Gly Lys Lys Phe Asn Leu 70 75 Pro Met Asp Asn Ile Lys Asn Phe Met Ala Glu Val Leu Lys Asn Gly Ph s Srle85 90 Ph s e l Lys Asn Met Gly Ser Ala Leu Val Gly Asn Gly Phe 100 105 110 Gly Ser Ser Lys Ser Asp Lys Thr Thr Asn Lays Met Ser Val Pro Gin 115 120 125 Val Arg Leu 130 INFORMATION FOR SEQ ID NO:1562: SEQUENCE CHARACTERISTICS: LENGTH: 297 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM:Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .297 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1562 Glu Glu Leu Leu Met Gly Gln Ala Phe Phe Lys Lys Ile Val Gly Cys 1 5 10 Phe Cys Leu Gly Tyr Leu Phe Leu Ser Ser Ala Ile Giu Ala Val Ala 25 Leu Asp Ile Lys Asn Phe Asn Arg Gly Arg Val Lys Val Val Asn Lys 40 1117 Lys Ile Ala Tyr Leu Gly Asp Glu Lys Pro Ile Thr Ile Trp Thr Ser 55 Leu Asp Asn Val Thr Val Ile Gin Leu Glu Lys Asp Glu Thr Ile Ser 70 75 Tyr Ile Thr Thr Gly Phe Asn Lys Gly Trp Ser lie Val Pro Asn Ser 90 Asn His Ile Phe Ile Gin Pro Lys Ser Val Lys Ser Asn Leu Met Phe 100 105 110 Glu Lys Glu Ala Val Asn Phe Ala Leu Met Thr Arg Asp Tyr Gin Glu 115 120 125 Phe Leu Lys Thr Lys Lys Leu Ile Val Asp Ala Pro Asp Pro Lys Glu 130 135 140 Leu Glu Glu Gin Lys Lys Ala Leu Glu Lys Glu Lys Glu Ala Lys Glu 145 150 155 160 Gin Ala Gin Lys Ala Gin Lys Asp Lys Arg Glu Lys Arg Lys Glu Glu 165 170 175 Arg Ala Lys Asn Arg Ala Asn Leu Glu Asn Leu Thr Asn Ala Met Ser 180 185 190 Asn Pro Gin Asn Leu Ser Asn Asn Lys Asn Leu Ser Glu Leu Ile Lys 195 200 205 Gin Gin Arg Glu Asn Glu Leu Asp Gin Met Glu Arg Leu Glu Asp Met 210 215 220 Gin Glu Gin Ala Gin Ala Asn Ala Leu Lys Gin Ile Glu Glu Leu Asn 225 230 235 240 S Lys Lys Gin Ala Glu Glu Ala Val Arg Gin Arg Ala Lys Asp Lys Ile 245 250 255 S Ser Ile Lys Thr Asp Lys Ser Gin Lys Ser Pro Glu Asp Asn Ser Ile 260 265 270 Glu Leu Ser Pro Ala Ile Ala Leu Gly Gly Leu Ile Leu Leu Cys Gly 275 280 285 SPro Ile Lys Pro Cys Ile Asn Ser Phe *"290 295 INFORMATION.FOR SEQ ID NO:1563: SEQUENCE CHARACTERISTICS: LENGTH: 255 amino acids TYPE: amino acid TOPOLOGY: linear 1* (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...255 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1563 Ser Cys Arg Met Leu Gly Lys Lys Asn Glu Glu Val Leu Ile Asp Glu 1 5 10 Asn Leu Val Gly Gly Val Ile Ala Leu Asp Arg Leu Ala Lys Leu Asn 25 Lys Ala Asn Arg Thr Phe Lys Arg Ala Phe Tyr Leu Ser Met Val Leu 40 Asn Val Ala Ala Val Thr Ser Ile Val Met Met Met Pro Leu Lys Lys 55 Thr Asp Ile Phe Val Tyr Gly Ile Asp Arg Tyr Thr Gly Glu Phe Lys 70 75 Ile Val Lys Arg Ser.Asp Ala Arg Gin Ile Val Asn Ser Glu Ala Val
I
1lls Val1 Lys Val Gin 145 Gin Ile Thr Ser Ile 225 Arg Ser Ser 115 Phe Vali Giu Ile Lys 195 G lu Ile Ile Ala 100 Leu Gin Asp Lys Lys 180 Gin As n Thr Lys Gly 110 Tyr Asn Ser Thr Giu 190 Gly Val Giu Asn a a a.
a. a a.
a. a a. a a a. a a a INFORMATION FOR SEQ ID NO:1564: i) SEQUENCE CHARACTERISTICS: LENGTH: 250 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .250 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i564 Lys Arg Leu Ile Gin Arg Asp Giu Thr Ile Ala Thr Gin Arg Glu Asn 1 Gly Met Pro Leu Lys Pro Gin Gly Phe 145 Ile Asn Pro 50 Asn Gin Arg Leu 130 Ala Ile Asp Sen Pro Gin Giu Ile 115 Glu Ile Ser Thr Asn Lys Giu Lys 100 Met His
S
Lys Thr Ser Gly Giu Ang Giu Leu Phe Lys 165' Gln Glu Gln Ser Lieu Tyr Ala Leu Val1 150 Phe His Sen 55 Leu Lys Giu Gly 135 Phe Leu His 40 Asn Gly Asn Leu Ala 120 Leu Leu Asn 25 Gly Asp Giu Ile Leu 105 His Cys Arg Leu Ser Leu Gin Leu 90 Met Sen Met Thr Leu 170 Leu Pro Asn Phe Glu Ile Leu Gly 140 Lys Tyr Giu Leu Leu His Ile G ly G ly 125 Ile Asn Phe Arg Asn Leu Giu Glu Gin 110 Tyr Phe Thr Tyr Ser Ala Asp Ala Lys Ala Ile Val1 Glu Tyr 175 Val Giu Sen Leu Thr Lys Leu Lys Phe Ile Leu Tyr 225 Phe 1119 Gly Val Gly Ala Val Leu Phe Phe Gly Leu Giu Thr Ile Arg Ser 180 185 190 Tyr Glu Leu Tyr Ile Leu Gly Ile Gly Ser Thr Asn Asp Lys Val 195 200 205 Phe Val Leu Lys Asn Ile Cys Phe Ile Gly Met Gly Tyr Leu Ile 210 215 220 Lys Val Ile Lys Val Ile Gly Ile Lys Asn Phe Ile Asn Gly Leu 230 235 240 Ala Ser Lys Lys Gin Gly Gly Aia Glu 245 250 INFORMATION FOR SEQ ID NO:1565: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 382 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .382 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1565 Gly Tyr Lys Asn Tyr Lys Met Leu Ala Lys Ile Val 9 *9S* *9 9 9 9* 9* 9 99 99 9 9 .9 9* 9*9* 99 *9 9 9*99 *999 9 99 9 9 999 9 1 Val Ala Phe Asn Ala Leu 50 Glu Asp 65 Ang Ala Glu Ala Lys Ala Lys Lys 130 Phe Thr 145 Lys Thr Ala Gin Asn Lys Glu Tyr 210 Asn Ile 225 Ala Lys Phe Giu 35 Lys Leu Lys Leu Tyr 115 Leu Gin Ser Ala Lys 195 Sen Asp Asp Gly 20 Ile Ala Val Val1 Glu 100 Gly Leu G lu Ser Leu 180 Ala Asn Tyr Ile Val Lys Arg Phe Leu Lys Asp Pro Asp Ile 165 Leu Ser Asn Tyr Ala Leu Lys Lys Arg 70 Leu Glu Leu Asn Lys 150 Phe Gin Arg Ile Leu 230 Gi1n Ser Glu Lys Lys Asp Thr Giu Pro 135 Giu Lys Met Leu Ser 215 Gin Lys Ala Gin 40 Leu Gin Leu Arg Gin 120 Tyr Arg Lys Gly Ala 200 Asn Leu Ala Asn 25 Glu Leu Lys Giu Gly 105 Ala Ala Leu Thn Val 185 Leu Leu Giu Thr Val Glu Asn Ile Asn 90 Lys Leu Tyr Ser Thr 170 Phe Ser Leu Arg Asn Giu Val Asn Lys 75 Lys Ile Lys Val1 Tyr 155 Ala Sen Tyr Ser Asn 235 Thr Gin Ala Thr Giu Tyr Leu Asp Leu 140 Tyr Thr Leu Lys Arg 220 Lys Leu Phe Phe Ala His Leu Lys Thr Asn 125 Asn Thr Asp Gin 205 Lys Phe Ile Sen Gly Lys Asp Val Lys Ala 110 Pro Gin Pro Lys Giu 190 Ala Giu Asp Phe Ser Sen Giu Phe Asp Giu Lys Leu Giu Gin Asp 175 G iu Ile Leu Sen Asn Leu Phe Asp Leu Tyr Lys Sen Tyr Thr Val 160 Lys Gin Glu Asp Lys 240 Sen 245 250 255 Giu Arg Leu Ala Phe Ser Met Ala Ilie Asp Lys Ile Asn Glu Lys Tyr 1120 Leu Asp Ser 305 Asn Met Ser Gly 275 Giu Ala Asp Ile Lys 355 265 Asn Lys Cys Ser Pro 345 Phe Lys Lys Lys Ser Asn 335 Thr Val
S.
a a a. a a a. a.
*ta* a a INFORMATION FOR SEQ ID NO:i566: SEQUENCE CHARACTERISTICS: LENGTH: 309 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .309 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1566 Lys Phe Ser Glu Val TIyr Phe Ile Met 1 Ala Leu Arg Glu Lys Asp Gly Leu Gin 145 Sen
LYS
Asp Phe Leu Leu Lys 50 Sen Leu Ala Tyr Ser 130 Giu Ala His Glu Asp 210 Ile Asn Leu Gin Leu Giu Glu 115 Lys Tyr Lys Leu Lys 195 Phe G ly 20 Ala Met Ile Asn Leu 100 Giu Ile Gin Lys Ser Met Leu 5 Lys His Lys Ile Gin Ang Phe Asp Lys Ser 165 Pro Arg Ser Asn Ala Ile 55 Leu Met Phe Sen Ala 135 Ser Asn Ala Ile Giu 215 Thr Lys Ala Ser Thr Leu His Lys Ala Lys Asp Lys Gly Leu His Ala Leu Lys Val His Asp Lys Pro His 125 Gin Val Leu 140 Leu Ala Leu 155 Leu Leu Glu Giu Lys Asp Ile Ile Arg 205 Giu Ser Asp 220 Phe is Asn Ala Gly Gin Met Leu Leu Lys Pro Ile 175 Met S er Met 1121 Asp Lys Phe Ile Giu Giu Giu Arg Ile Asp Lys Val Tyr Ala Arg Ile 225 230 235 240 Ile Val Giu Lys Giu Ser Gin Lys Lys Ile Vai Ile Gly Lys Asn Giy 245 250 255 Val Asn Ile Lys Arg Ile Giy Thr Asn Ala Arg Leu Lys Met Gin Giu 260 265 270 Val Gly Giu Lys Lys Val Phe Leu Asn Leu Gin Val Ile Ala Gin Lys 275 280 285 Ser Trp Ser Lys Giu Giu Lys Ser Leu Gin Lys Leo Gly Tryr Ile Tyr 290 295 300 Gin Arg Asn Arg Asp 305 INFORMATION FOR SEQ ID NO:i567: SEQUENCE CHARACTERISTICS: LENGTH: 392 amino acids TYPE: amino acid TOPOLOGY: iinear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori I(ix)
FEATURE:
NAME/KEY: misc-feature LOCATION .392 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i567 so s Phe Leu Ser Leu Ser Leu Ile Giu Arg Asp Leu Lys Thr Met Aia Lys i 5 10 e:le Leu Lys Pro Asn Leu Asp Arg Asp Giu Leu Asn Thr Leu Tyr Lys 25 Ala Asn Leu Aia Tyr Ala Lys Asn Thr His Glu His Tyr Phe Lys Phe 40 so,* Lys Lys Asp Vai Asp Tyr Lys Leu Phe Asn Pro Ser Ile Met His Glu so 55 Gin Cys Ser Ile Ser Phe Val Gly Gly Gin Gly Ala Lys Arg Leo Leu 70 75 Tyr Ile Leu Tyr Lys Leu Ala Phe Asn Ala Lys Ser Asn Lys Ile Ala to085 90 Leu Asp Arg His Tyr Ala Lys Met Phe Leo Gin Val Val Ala Arg Thr 100 105 110 Leu Ile Lys Asn Val Asn Ile Leu Glu Giu Gin Gly Phe Ile Glu Val 115 120 125 Ile Lys Gly Lys Gin Arg Tyr Leu Tyr Val Tyr Leo Lys Asp Tyr Arg 130 135 140 Giu Leu Giu Cys Leu Val Lys Ser Lys Met Ala Lys Tyr Val Met Tyr 145 150 155 160 Leu Arg Gin Phe Phe Asp Tyr Leo Asp Arg Lys Arg Arg Tyr Gly Phe 165 170 175 Asp Phe Thr Leo Lys Asn Leo Ala Phe Ala Lys Thr Lys Glu Ser Leo 180 185 190 Pro Axg His Leo Asn Asp Lys Asp Leo Lys Ser Phe Leo Lys Thr Leo 195 200 205 Leo Asp Tyr Lys Pro Ala Thr Ser Phe Glu Lys Arg Asn Lys Cys Ile 210 215 220 Leu Leo Ile Val Ile Leu Gly Gly Leo Arg Lys Cys Giu Val Leo Asn 225 230 235 240 Ile Glu Leu Lys His Ile Gin Val Glu Glu Gin Asn Tyr Ser Ile Leu 1122 245 250 255 Ile Gin Gly Lys Gly Arg Lys Glu Arg Lys Ala Tyr Ile Lys Lys Ser 260 265 270 Leu Leu Glu Pro Ser Leu Asn Ala Trp Ile Ser Asp Asp Tyr Arg Leu 275 280 285 Lys Tyr Phe Asn Gly Ala Tyr Leu Phe Lys Lys Asp Lys Gin Lys Ser 290 295 300 Gin Asn Ser Leu Thr Leu Tyr Asn Phe Ile Pro Leu Ile Phe Lys Leu 305 310 315 320 Ala Gin Ile Lys His Tyr Lys Gin Tyr Giy Thr Gly Leu His Leu Phe 325 330 335 Arg His Ser Phe Ala Thr Leu Ile Tyr Gin Glu Thr Gin Asp Leu Val 340 345 350 Leu Thr Ser Arg Ala Leu Gly His Ser Ser Leu Leu Ser Thr Lys Ile 355 360 365 Tyr Ile His Thr Thr Gin Giu His Asn Lys Lys Val Ala Leu Val Phe 370 375 380 Asp Ser Leu Ile Glu Asn Lys Lys 385 390 INFORMATION FOR SEQ ID NO:1568: 060 SEQUENCE CHARACTERISTICS: LENGTH: 170 amino acids TYPE: amino acid TOPOLOGY: linear :0 (ii) MOLECULE TYPE: protein HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/Krf: misc-feature LOCATION .170 :*Ot (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i568 *too *to*Lys Az-g Lys Giu His Cys Met Lys Asn Leu Arg His Phe Arg Lys Leu 1 5 10 Ile Ala Phe Leu Gly Phe Ser Pro Leu Leu Leu Gin Ala Asp Met Thr 25 Thr Phe Phe Asn Ser Ile Giu Gin Gin Leu Thr Sen Pro Thr Ala Lys 40 Gly Ile Leu Met Val Ile Phe Leu Gly Leu Ala Ile Phe Ile Trp Lys s0 55 Asn Leu Asp Arg Trp Lys Glu Ile Leu Met Thr Val Leu Ala Leu Lys 70 75 Glu Val Pro Met Gin Leu Val Ala Ile Sen Val Sen Asn Leu Lys Giu 90 Ile Sen Sen Lys Giu Lys Phe Leu Trp Leu Asn Ala Lys Sen Phe Leu 100 105 110 Leu Ser Gly Phe Val Pro Phe Ile Met Ile Pro Trp Leu Asp Ile Leu 115 120 125 Asn Ser Phe Val Leu Tyr Val Cys Phe Leu Leu Ile Phe Ser Ile Ala 130 135 140 Glu Phe Phe Asp Giu Asp Ile Ser Asp Ile Leu Ile Ala His Ser Lys 145 ISO 155 160 Ile Lys Thr Lys Ala Asn Ser Phe Tyr Ala 165 170 1123 INFORMATION FOR SEQ ID NO:1569: SEQUENCE
CHARACTERISTICS:
LENGTH: 209 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .209 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1S69 Lys Ser Arg Asn Phe Ser Tyr Asn Gin Thr Giu Lys Ile Trp Giu Asn 1 5 10 His Phe Asn Leu Phe Sen Val Gly Ile Gly Met Ala Giu Giu Gin Giu 25 Asn Thr Ala Gin Gin Pro Gin Lys Lys Ser Lys Ala Leu Leu Phe Val 35 40 Ile Ile Gly Ser Val Leu Val Met Leu Leu Leu Val Gly Val le Ile so* 55 60 Met Leu Leu Met Gly Asn Lys Giu Glu Ser Lys Giu Asn Ala Ser Lys 70 75 Asn Thr Gin Giu Val Gin Ala Asn Pro Met Ala Asn Lys Asn Gin Giu as 90 9 Ala Lys Giu Gly Ser Asn Ile Gin Gin Tyr Leu Val Leu Gly Pro Leu 100 105 110 Tyn Ala Ile Asp Ala Pro Phe Ala Val Asn Leu Val Ser Gin Asn Gly *115 120 125 S Arg Arg Tyr Leu Lys Ala Sen Ile Ser Leu Giu Leu Sen Asn Glu Lys 130 135 140 Leu Leu Asn Giu Val Lys Val Lys Asp Thr Ala Ile Lys Asp Thr Ile 145 150 155 160 le Giu Ile Leu Sen Sen Lys Ser Val Glu Giu Val Val Thr Asn Lys 165 170 175 Gly Lys Asn Lys Leu Lys Asp Glu Ile Lys Ser His Leu Asn Ser Phe 180 185 190 Leu Ile Asp Gly Phe Ile Lys Asn Val Phe Phe Thr Asp Phe Ile Ile 195 200 205 Gin INFORMATION FOR SEQ ID NO:1570: SEQUENCE CHARACTE RISTICS: LENGTH: 183 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINALJ~
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: 1124 NAME/KEY: misc feature LOCATION 1 183 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1570 dly Ser Al a Thr His Tyr Leu Pro Glu Leu 145 Phe Ser Ser Met Met Thr Glu His Gly Ser Asn Asn Arg Gly Gly 130 Pro Asn Ser Arg S er Leu Gly Glu His Glu Lys Ile Trp Phe Cys Leu Ile Arg Glu 100 Leu Arg Glu Leu Ala 180 Glu Ile Leu Asn Gly His Leu Trp Ala 165 Lys Lys Tyr Gin Arg 70 Pro Phe Leu Ile Arg 150 Leu His Met Giu Leu Lys 10 Lys Pro Gly Leu 25 Asn Lys Phe Gin 40 Lys His Leu Lys 55 Asn Asp Lys Val Glu Arg Phe Tyr 90 Met Asn Phe Thr 105 Tyr Val His Lys 120 Lys Thr Leu Ser 135 Val Phe Pro Ser Pro Tyr Glu Vai 170 Leu Leu Gly Arg Arg Giu 75 His Ala Gly Met Asn Ile Glu Val1 Glu Asn Lys Tyr His Lys 140 Glu Lys Arg Asn Ile Ile Ala As n Thr 125 Leu Trp Ile Met Ala Glu Val1 Gin Thr 110 Giu Ala Pro Asp Asp Met Ile Phe Leu Lys Leu Gin Lys Thr Tyr Leu Ala Asp Leu Thr Gly Gly Giu Phe Ala Lys Giu Arg Gly 175 INFORMATION FOR SEQ ID NO:1571: SEQUENCE CHARACTERISTICS: LENGTH: 275 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc feature LOCATION 1. 275 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:iS71 Pro Phe Leu Lys Gly Phe L-eu Met Ser Glu Lys Giu 1 S 10 Val Ile Leu Glu Giu Giu Asn Asn Gly Ser Gly Thr 25 Leu Ile Val Ala Ile Ala Ile Ile Ile Leu Ala Val 40 Phe Trp Lys Ser Thn Arg Val Ala Pro Lys Glu Thr 55 60 Asp Sen Gly Met Gin. Lys Ile Gly Asn Thr Lys Asp 70 75 Asp Glu Phe Glu Ser Leu Asn Met Asp Ser Pro Lys 90 Leu Asp Lys Val Val Asp Asn Ile Lys Lys Gin Giu 100 105 Arg Lys Leu Phe Glu Gin Ser Leu Lys Leu Leu Lys Glu Glu 110 Asn Val Met Gin Lys Asp Asn Glu Phe Val Thr Asp Lys Sen 1125 Met Pro Ile Gin Thr Asp Gin Ala Gin Met Glu Met Lys Thr Thr Glu 115 120 125 Glu Lys Gin Glu Ser Gin Lys Glu Leu Lys Ala Val Glu Pro Ile Pro 130 135 140 Met Ser Thr Gin Lys Glu Ser Gin Ala Val Ala Lys Lys Glu Thr Pro 145 150 155 160 His Lys Lys Pro Lys Val Ala Pro Lys Asp Lys Glu Ala His Lys Asp 165 170 175 Lys Ala Lys His Ala Ala Lys Glu Pro Lys Val Lys Lys Glu Ala Arg 180 185 190 Lys Glu Val Ser Lys Lys Ala Asn Ser Lys Thr Asn Leu Thr Lys Gly 195 200 205 His Tyr Leu Gin Val Gly Val Phe Ala His Thr Pro Asn Lys Ala Phe 210 215 220 Leu Gin Glu Phe Asn Gin Phe Pro His Lys Ile Glu Asp Arg Gly Ala 225 230 235 240 Thr Lys Arg Tyr Leu Ile Gly Pro Tyr Lys Ser Lys Gin Glu Ala Leu 245 250 255 Met His Ala Asp Glu Val Ser Lys Lys Met Thr Lys Pro Val Val Ile 260 265 270 Glu Val Arg 275 INFORMATION FOR SEQ ID NO:1572: SEQUENCE CHARACTERISTICS: LENGTH: 189 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES S(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...189 SEQUENCE DESCRIPTION: SEQ ID NO:1572 Ser Arg Leu Gin Lys Ala Ile Ile Lys Arg Val Glu Met Leu Glu Lys 1 5 10 Leu Ile Glu Arg Val Leu Phe Ala Thr Arg Trp Leu Leu Ala Pro Leu 25 Cys Ile Ala Met Ser Leu Val Leu Val Val Leu Gly Tyr Val Phe Met 40 Lys Glu Leu Trp His Met Leu Ser His Leu Asp Thr Ile Ser Glu Thr 55 Asp Leu Val Leu Ser Ala Leu Gly Leu Val Asp Leu Leu Phe Met Ala 70 75 Gly Leu Val Leu Met Val Leu Leu Ala Ser Tyr Glu Ser Phe Val Ser 90 Lys Leu Asp Lys Val Asp Ala Ser Glu Ile Thr Trp Leu Lys His Thr 100 105 110 Asp Phe Asn Ala Leu Lys Leu Lys Val Ser Leu Ser Ile Val Ala Ile 115 120 125 Ser Ala Ile Phe Leu Leu Lys Arg Tyr Met Ser Leu Glu Asp Val Leu 130 135 140 Ser Ser Ile Pro Lys Asp Thr Pro Leu Ser His Asn Pro Ile Phe Trp 145 150 155 160 Gin Val Val Ile His Leu Val Phe Val Cys Ser Ala Leu Leu Thr Ala 1126 165 170 Val Thr Asn Asn Ile Ala Phe Ser Gin Lys Giu Arg His 180 185 INFORMATION FOR SEQ ID NO:1573: SEQUENCE CHARACTERISTICS: LENGTH: 237 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: maisc-feature LOCATION .237 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1573 9 *0 4 0004
S
*4 Gly Gly Leu Val Met 65 Phe Gly
LYS
Asp Phe 145 Val Asp Asn Asp Thr 225 Leu Ile Gly Gly s0 Thr Phe Leu Thr Leu 130 Pro
LYS
Glu
LYS
Leu 210 Pro Msn Tyr Ile Asp Leu Ala Leu Leu Val Val Arg Ile 35 Msn Asn Leu Gly Phe 115 Met Thr His Val Ala 195 Pro Pro Gly Phe Val Leu Leu Phe Leu Ile Ala Leu 85 Ile Ile 100 Leu Val Lys Asp Met Lys Val Glu 165 Lys Msn 180 Thr Asp Lys Asr Ile Pro Tyr Gly Sen Gly 70 Gly Asp Leu Ala Sen 150 Lys Lys Lys Met Thr 230 His Val Glu 55 Phe Val Lys Ser Asn 135 Val Asn Gly Gly Leu 215 Pro Gly Tyr 40 His Leu Leu Ala Phe 120 Ala Ala Leu Sen Val 200 C iu Ser Phe 25 Leu Leu Leu Leu Leu 105 Ile Tyr Ser Lys Ile 185 Glu Pro Msn Val Ala Tyn Val Gly Gly Leu Leu Lys Asp 170 Asp Ala Lys Lys Ser Sen Asp Leu 75 Lys Phe Tyr Gin Ile 155 Asn Msn Leu His Gl 235 Glu Arg Leu Ala Met Ile Ala Giu 140 Met Leu Ala Lys Asn 220 Pro Val1 Ile Tyr Arg Sen Leu Phe Leu 125 Lys Ang C iu Lys Giu 205 Lys Leu Val1 Ala Ser Asn Ile Val Ser 110 Ser Ser Leu Giu Glu 190 Lys Pro Phe Thn Ala Thr Val1 Ser Leu Met Ile Gly 160 Ser Phe Lys Gin INFORMATION FOR SEQ ID NO:1574: SEQUENCE CHARACTERISTICS: CA) LENGTH: 395 amino acids TYPE: amino acid CD) TOPOLOGY: linear (ii) MOLECULE TYPE: protein 1127 (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .395 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1574 Ser Leu Trp Val Glu Asn Pro Ilie Leu Leu Ser His Ser Gin Val Tyr 1 5 10 Sen Pro Pro Arg Cys Tnp Val Phe Lys Thr Pro Ang Asn Ser Ala Phe 25 Ala Leu Gly Phe Phe Val Gly Ala Leu Leu Phe Tyr Trp, Cys Ala Leu 40 Arg Leu Sen His Ser Asp Phe Thr Tyr Leu Leu Pro Leu Ile Ile Val 55 Leu Val Ala Leu Val Tyr Gly Val Leu Phe Tyr Leu Leu Leu Tyr Phe 70 75 Glu Asn Pro Tyr Phe Arg Leu Leu Ser Phe Leu Gly Ser Ser Phe Ile 90 His Pro Phe Gly Phe Asp Trp, Leu Val Pro Asp Sen Phe Phe Ser Tyr 100 105 110 Sen Val The Arg Val Asp Lys Leu Sen Leu Gly Leu Ile Phe Leu Ala .115 120 -125 *Cys Ile Phe Leu Ser Ala Gin Asn Leu Lys Lys Tyr Arg Met Ile Gly 130 135 140 Val Leu Leu Leu Leu Gly Ala Leu Asp Phe His Phe Phe Lys Ile Ser 145 150 155 160 Asp Leu Lys Glu Val Gly Asn Ile Glu Leu Val Ser Thr Arg Thr Pro 165 170 175 Gin Asp Leu Lys Phe Asp Sen Asri Tyr Leu Asn As Ile Giu Asn Asn 180 185 190 le Leu Lys Giu Ile Lys Leu Ala Gin Ser Lys Gin Lys Thr Leu Ile :195 200 205 Val Phe Pro Glu Thr Ala Tyr Pro Ile Ala Leu Glu Asn Sen Pro Phe 210 215 .220 Lys Thr Gin Leu Giu Asp Leu Ser Ala Lys Ile Ala Ile Leu Ile Gly 225 230 235 240 Thr LuAng Ala Gin Gly Tyr Sen Leu Tyr Asn Sen Sen Phe Leu Phe 245 250 255 Sen Lys Lys Ser Val Gin Ile Ala Asp Lys Val Ile Leu Ala Pro Phe *260 265 270 Gly Glu Ile Met Pro Leu Pro Glu Phe Leu Gin Lys Pro Leu Glu Lys 275 280 285 Leu Phe Phe Gly Giu Ser Ala Tyr Leu Tyr Ang Asn Ala Pro His Phe 290 295 300 Sen Asp Phe Thr Leu Asp Asp Phe Thr Phe Ang Pro Leu Ile Cys Tyr 305 310 315 320 Giu Gly Thr Ser Lys Pro Ala Tyr Ser Ser Sen Pro Ser Lys Val Phe 325 330 335 Ile Leu Met Ser Asn Asn Ala Trp Phe Ser Pro Sen Ile Glu Pro Thr 340 345 350 Leu Gin Arg Thn Leu Leu Lys Tyr Tyr Ala Arg Ang Tyr Asp Lys Ile 355 360 365 Ile Leu His Ser Ala Asn Phe Sen Thr Sen Tlyr Ile Leu Ser Pro Ser 370 375 380 Leu Leu Gly Asp Ile. Leu Phe Arg Lys Ang Ser 385 390 395 INFOMTION FOR SEQ ID NO:1575: 1128 SEQUENCE CHARACTERISTICS: LENGTH: 216 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE:- ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .216 4xi) SEQUENCE DESCRIPTION: SEQ ID NO:i575 Giu Tbhr Ile Met Ile Lys Ala Ile Asp Ile Ser His Ala Phe Giu Lys 1 5 10 1s Pro Leu Tyr Asn Gly Val Asn Leu Arg Ile Lys Pro Lys Giu Sen Leu 25 Ala Ile Leu Giy Vai Ser Gly Ser Gly Lys Sen Thn Leu Leu Sen His 935 40 Leu Ala Thn Met Leu Lys Pro Asp Ser Gly Thr Val Ser Leu Leu Glu 55 9..His Gin Asp Ile Tyn Ala Leu Asn Sen Lys Lys Leu Leu Giu Leu Arg 69 5 70 75 Arg Leu Lys Val Gly Ile Val. Phe Gin Sen His Tyn Leu Phe Lys Giy 90 Phe Sen Ala Leu Giu Asn Leu Gin Val Ala Sen Ile Leu Ala Lys Gin 100 105 110 Giu Ile Asn His Sen Leu Leu Giu Gin Leu Gily Ile Ala His Thr Leu *115 120 125 Lys Gin Gly Val Gly Giu Leu Ser Gly Gly Gin Gin Gin Arg Leu Sen 130 135 140 Ile Ala Arg Val Leu Ser Lys Lys Pro Gin Ile Ile Ile Ala Asp Giu 145 150 155 160 Pro Tbr Gly Asn Leu Asp Thr Thr Ser Ala Asn Gin Vai Ile Sen Met 15170 175 Leu Gin Asn Tyr Ile Thn Giu Asn Giu Gly Ala Leu Vai Leu Ala Thr 180 185 190 His Asp Giu His Leu Ala Phe Thn Cys Sen Gin Val Tyr Ang Leu Giu .195 200 205 Lys Giu Ser Leu Ile Lys Giu Lys 210 215 INFORMATION FOR SEQ ID NO:i576: SEQUENCE CHARACTERISTICS: LENGTH: 6i amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacten pyloni (ix) FEATURE: NAME/KEY: misc_feature 1129 LOCATION 1...61 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1576 Ser Leu Ala Pro Lys Leu Lys Ala Phe Phe Lys Val Ala Leu Ser Cys 1 5 10 Lys Ala Val Ile Lys Ile Thr Gly Val Glu Ile Lys Lys Ser Phe Leu 25 Met Arg Leu Asn Asn Ser Lys Leu Phe Ile Ser Gly Thr Cys Thr Ser 40 Lys Ser Lys Arg Leu Lys Arg Ser Thr Glu Ser Leu Ser 55 INFORMATION FOR SEQ ID NO:1577: SEQUENCE CHARACTERISTICS: LENGTH: 300 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...300 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1577 Phe Ala Leu His Lys Lys Val Leu Leu Ala Leu Thr Ala Ser Leu Ile 1 5 10 Cys Gin Glu Ser Leu Phe Ala Lys Asp Lys Asp Tyr Thr Leu Gly Lys 25 Val Ser Thr Ala Gly Lys Lys Asp Arg Ser Asp Tyr Ser Gly Gin Val 35 40 Asn Leu Gly Tyr Ser Gly Ile Thr Ala Pro Lys Ser Trp Gln Asp Glu 50 55 Glu Val Lys Lys Tyr Thr Gly Ser Arg Thr Val Ile Ser Asn Lys Ala 70 75 Leu Thr Gin Gin Ala Asn Gin Ser Ile Glu Glu Ala Leu Gln Asn Val se 85 90 Pro Gly Leu Gin Ile Arg Asn Ala Thr Gly Val Gly Ala Met Pro Thr 100 105 110 Ile Gin Ile Arg Gly Phe Gly Ala Gly Gly Ser Gly His Ser Asp Ala 115 120 125 Thr Leu Met Leu Val Asn Gly Ile Pro Val Tyr Met Ala Pro Tyr Ala 130 135 140 His Ile Glu Leu Asp Ile Phe Pro Val Thr Phe Gin Ala Ile Asp Arg 145 150 155 160 Ile Asp Val Ile Lys Gly Gly Gly Ser Val Gin Tyr Gly Pro Asn Thr 165 170 175 Tyr Gly Gly Ile Val Asn Ile Ile Thr Lys Pro Ile Pro Asn Gin Trp 180 185 190 Glu Asn Gin Ala Ala Glu Arg Ile Thr Tyr Trp Ala Lys Ala Arg Asn 195 200 205 Ala Gly Phe Ala Ala Pro Pro Asp Lys Thr Gly Asp Pro Ser Phe Ile 210 215 220 Lys Ser Leu Gly Asn Asn Leu Leu Tyr Asn Thr Tyr Val Arg Ser Gly 225 230 235 240 Gly Met Ile Asn Lys:His Val Gly Ile Gln Ala Gin Ala Asn Trp Val 1130 Arg Trp Tyr 245 250 255 Gly Gin Gly Phe Arg Asp Asn Ser Pro Ser Ser Ile Ser Asn Tyr 260 265 270 Leu Asp Gly Val Tyr Asp Ile Asn Glu Ser Asn Gly Ile Lys Ala 275 280 285 Tyr Gin Tyr Tyr Asp Phe Ala Ile Ala Gin Pro 290 295 300 INFORMATION FOR SEQ ID NO:1578: SEQUENCE CHARACTERISTICS: LENGTH: 275 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...275 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1578
C..
S
S
*r S.
S
*Sg Val 1 Glu Cys Pro Phe Ala Ile Thr Asp Glu 145 Leu Lys Gly Thr Leu 225 Gly Ser Ile Leu Val Ile Ile Glu Pro 3er Leu Lys 50 Thr Asp Ala Ala Leu 130 Tyr Ser Lys Gly Lys 210 Asn Lys Val Gly 35 Glu Arg Gly Arg Thr 115 Ala Tyr Ala Asp Cys 195 Asp Asp Gly Met 20 Ala Leu Ala Cys Glu 100 Ala Glu Ser Thr Leu 180 Ser Phe Ala Val 5 Leu Leu Ile Lys Ala Asn Lys Phe Lys Phe 165 Glu Lys SLys Lys SAla 245 Gly Cys Phe Lys 70 Ile Ala Val Tyr Ser 150 Tyr Tyr Leu Lys Gly 230 Lys Ser Leu Ser 55 Tyr Leu Arg Cys Phe 135 Cys Asn Tyr Gly Ala 215 Cys Asp Val Cys 40 Gly Phe Arg Glu Lys 120 Asn Lys Asp Ser Gly 200 Phe Tyr Glu Lys 25 Gly Ile Glu Glu Ser 105 Leu Val Leu Met Lys 185 Asp Glu Ala Lys Tyr 10 Lys Gly Thr Lys Val 90 Ile Asn Asn Asn Ile 170 Ala Tyr Tyr Leu SGin 250 Thr Phe Tyr Lys Ala Leu Ile Ala 75' Tyr Glu Asp Asp Asn 155 Lys Cys Phe Ser Ala 235 Thr Val Met Tyr Cys Ser Lys Ala Leu 140 Val Gly Glu Phe Ala 220 Ala Thr Phe Ala Thr Lys Ser Ala Glu 125 Lys Glu Leu Leu Gly 205 Lys Phe Glu Arg Glu Asp Ser Gly Leu 110 Lys Asn Gly Lys Asn 190 Glu Ala Tyr Asn Arg Val Gin Lys Asn Lys Glu Cys Ala Cys Lys 175 Asn Gly Cys Asn Leu 255 Glu Leu Asp Asn Asp Ala His Lys Leu Met 160 Asp Gly Val Glu Glu 240 Glu Lys Ser Cys Lys 260 Gin Lys Gin 275 Leu Gly Leu Lys Glu Ala Cys Asp Ile Leu Lys Glu 265 270 1131 INFORMATION FOR SEQ ID NO:1579: SEQUENCE CHARACTERISTICS: LENGTH: 139 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...139 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1579 Thr Arg Lys Ser Ser Ala Ser Met Ser Glu Asn Glu Lys His Pro His 1 5 10 Arg Val Leu Gin Leu Ile Lys Ser Ser Gly Ile Thr Pro Gly Ile Val 25 Leu Asn Pro His Thr His Glu Glu Ser Ile Lys Tyr Leu Leu Glu Ser 35 40 Val Gly Leu Val Leu Leu Met Ser Val Asn Pro Gly Phe Gly Gly Gin 50 55 Lys Phe Leu Asp Leu Val Leu Glu Lys Cys Leu Lys Val Lys Glu Leu S 65 70 75 Ile Lys Arg Tyr Asn Pro Ser Cys Leu Leu Glu Val Asp Gly Gly Val 90 Asn Asp Lys Asn Ile Phe Glu Leu Gin Gin Ala Gly Val Asp Val Val 100 105 110 Val Ser Gly Ser Tyr Ile Phe Glu Ser Lys Asp Arg Lys Leu Ala Ile 115 120 125 Glu Gly Leu Gin Asn Val Arg Gin Pro Leu Ala 130 135 INFORMATION FOR SEQ ID NO:1580: SEQUENCE CHARACTERISTICS: LENGTH: 315 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc feature LOCATION 1...315 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1580 Lys Leu Leu Arg Val Leu His Lys Met Ile Lys Lys Ala Ala Lys Thr 1 5 10 Pro Phe Phe Lys Ile Leu Phe Gin Ala Leu Ser Tyr Asn Ile Arg Met 1132 25 Lys Asp Leu Asn Lys Thr Ile Gly Val Phe Val Arg Pro Thr His His 40 Gin Asn Ala Leu Phe Lys Glu Leu Glu Gin Ala Lys Glu Trp Val Leu 55 Thr Leu Leu Glu Asp Glu Gly Phe Glu Ser Phe Met Ile Asp Ser Leu 70 75 Asp Gly Ala Lys Asp Ala Gin Leu Ile Lys Lys Ala Tyr Ala Phe Leu 90 Cys Leu Gly Gly Asp Gly Thr Ile Leu Gly Ala Leu Arg Met Thr His 100 105 110 Ala His Asn Lys Pro Cys Phe Gly Val Arg Ile Gly Asn Leu Gly Phe 115 120 125 Leu Ser Ala Val Glu Leu Asn Gly Leu Lys Asp Phe Leu Gin Asp Leu 130 135 140 Lys Gin Asn Arg Ile Lys Leu Glu Glu His Leu Ala Leu Glu Gly Arg 145 150 155 160 Ile Gly Asn Thr Ser Phe Tyr Ala Ile Asn Glu Ile Val Ile Ala Lys 165 170 175 Lys Lys Ala Leu Gly Val Leu Asp Ile Lys Ala Cys Ala Gly His Thr 180 185 190 Pro Phe Asn Thr Tyr Lys Gly Asp Gly Leu Ile Ile Ala Thr Pro Leu 195 200 205 Gly Ser Thr Ala Tyr Asn Leu Ser Ala His Gly Pro Ile Val His Ala S. 210 215 220 Leu Ser Gin Ser Tyr Ile Leu Thr Pro Leu Cys Asp Phe Ser Leu Thr 225 230 235 240 Gin Arg Pro Leu Val Leu Gly Ala Glu Phe Cys Leu Ser Phe Cys Ala 245 250 255 His Glu Asp Ala Leu Val Val Ile Asp Gly Gin Ala Thr Tyr Asp Leu 260 265 270 Lys Ala Asn Gin Pro Leu Tyr Ile Gin Lys Ser Pro Thr Thr Thr Lys 275 280 285 Leu Leu Gin Lys Asn Ser Arg Asp Tyr Phe Lys Val Leu Lys Glu Lys 290 295 300 Leu Leu Trp Gly Glu Ser Pro Asn Lys Lys Arg 305 310 315 INFORMATION FOR SEQ ID NO:1581: SEQUENCE CHARACTERISTICS: LENGTH: 218 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...218 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1581 Arg Tyr Asn Thr Pro Met Gin Lys Lys Ile Phe Leu Leu Glu Asp Asp 1 5 10 Tyr Leu Leu Ser Glu Ser Ile Lys Glu Phe Leu Glu His Leu Gly Tyr 25 Glu Val Phe Cys Ala Phe Asn Gly Lys Glu Ala His Glu Arg Leu Ser 40 1133 Val Glu Arg Phe Asn Leu Leu Leu Leu Asp Val Gin Val Pro Glu Met 55 Asn Ser Leu Glu Leu Phe Lys Arg Ile Lys Asn Asp Phe Leu Ile Ser 70 75 Thr Pro Val Ile Phe Ile Thr Ala Leu Gin Asp Asn Ala Thr Leu Lys 90 Asn Ala Phe Asn Leu Gly Ala Ser Asp Tyr Leu Lys Lys Pro Phe Asp 100 105 110 Leu Asp Glu Leu Glu Ala Arg Ile Lys Arg Phe Phe Asn Asp Asp Pro 115 120 125 Ile Glu Ile Met Pro Asn Ile Phe Tyr His Gin His Ala Leu Asn Val 130 135 140 Lys Gly Lys Lys Glu Ile Leu Ala Pro Lys Thr Ala Gin Leu Leu Glu 145 150 155 160 Tyr Phe Leu Glu His Lys Gly Gin Ile Ile Ser Ser Gin Ala Leu Glu 165 170 175 Asn Asn Leu Trp Glu Gin Ala Ile Asp Asp Ser Thr Leu Arg Thr Tyr 180 185 190 Ile Lys Val Leu Arg Lys Leu Leu Gly Lys Asn Cys Ile Glu Thr His 195 200 205 Lys Gly Val Gly Tyr Arg Phe Asn Pro Leu 210 215 INFORMATION FOR SEQ ID NO:1582: SEQUENCE CHARACTERISTICS: LENGTH: 358 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...358 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1582 Cys Gly Ala Asn Arg Ser Lys Gly Arg Gly Gly Phe Ser Ser Lys Cys 1 5 10 Ala Gly Ala Asn Ser Gly Tyr Ser Asn Glu Ala Tyr Glu Ser Val Gly 25 Ala Lys Ile Val Asp Ser Lys Thr Ala Trp Gly Gin Asp Leu Val Val 40 Lys Cys Lys Glu Pro Leu Glu His Glu Tyr Pro Leu Leu Lys Glu Lys 55 Ala Thr Leu Phe Ser Tyr Leu Asp Leu Ala Tyr Gin Lys Ser Leu Cys 70 75 Glu Met Phe Ile Asn Lys Lys Ile Thr Ser Ile Cys Thr Glu Thr Ile 90 Ala Gly Pro Lys Asn Asp Tyr Pro Ile Leu Ala Pro Met Ser Val Val 100 105 110 Ala Gly Arg Leu Ala Ala His Leu Val Gin His Tyr Leu Leu Ala Leu 115 120 125 Glu His Val Lys Gly Phe Met Gly Lys Gly Val Met Leu Gly Gly Leu 130 135 140 Ser Gly Ala Gin Arg Ala Lys Ile Val Val Ile Gly Gly Gly Val Val 145 150 155 160 Gly Met Glu Ser Ala Lys Val Leu Ser Gin Met Gly Ala Lys Val Thr 1134 165 170 175 Ile Leu Glu Leu Asp Tyr Ala Lys Leu Gin Asn His Pro Tyr Tyr His 180 185 190 Leu Tyr Asp Leu Glu Val Leu Ser Val Asn Glu Ala Asn Ile Ile Gin 195 200 205 Ala Leu Asn Gly Ala Val Gly Leu Val Gly Ala Val Leu Val Thr Ala 210 215 220 Ser Gin Thr Pro Lys Val Ile Leu Arg Arg His Leu Lys Tyr Met Gin 225 230 235 240 Thr Gin Gly Val Val Ile Asp Val Ala Cys Ser Leu Gly Gly Cys Ile 245 250 255 Arg Ala Ile Arg Gln Ala Ser His Ser Asn Pro Val Tyr Val Glu Glu 260 265 270 Ser Leu Leu His Tyr Gly Val Pro Asn Met Pro Gly Ile Val Ala Lys 275 280 285 Thr Ser Ser Thr Ala Tyr Ser His Ala Ser Val Pro Tyr Leu Leu Tyr 290 295 300 Tyr Leu Glu His Gly Leu Lys Gly Phe Leu Thr Ala Asn Thr Lys Ile 305 310 315 320 Val Ala Asn Thr Leu Gly Gly Leu Ser Ala Tyr Asn Gly Tyr Ile Thr 325 330 335 Gin Glu Gly Ile Ala Lys Ala Phe Asn Leu Ala Phe Lys Ser Pro Leu 340 345 350 Glu Ile Leu Lys Glu Leu 355 INFORMATION FOR SEQ ID NO:1583: SEQUENCE CHARACTERISTICS: LENGTH: 163 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...163 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1583 Lys Gly Lys Arg Val Lys Asn Met Arg Asp Phe Asn Asn Ile Gin Ile 1 5 10 Thr Arg Leu Lys Val Arg Gin Asn Ala Val Phe Glu Lys Leu Asp Leu 25 Glu Phe Lys Asp Gly Leu-Ser Ala Ile Ser Gly Ala Ser Gly Val Gly 40 Lys Ser Val Leu Ile Ala Ser Leu Leu Gly Ala Phe Gly Leu Lys Glu 55 Ser Asn Ala Ser Asn Ile Glu Val Glu Leu Ile Ala Pro Phe Leu Asp 70 75 Thr Glu Glu Tyr Gly Ile Phe Arg Glu Asp Glu His Glu Pro Leu Val 90 Ile Ser Val Ile Lys Lys Glu Lys Thr Arg Tyr Phe Leu Asn Gln Thr 100 105 110 Ser Leu Ser Lys Asn Thr Leu Lys Ala Leu Leu Lys Gly Leu Ile Lys 115 120 125 Arg Leu Ser Asn Asp Arg Phe Ser Gin Asn Glu Leu Asn Asp Ile Leu 130 135 140 1135 Met Leu Ser Leu Leu Asp Gly Tyr Ile Gin Asn Lys Asn Arg Arg Leu 145 150 155 160 Ala Pro Phe INFORMATION FOR SEQ ID NO:1584: SEQUENCE CHARACTERISTICS: LENGTH: 297 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .297 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1584 Ser Asn His Lys Arg Val Phe Met Asp
I
His Lys Gin Leu Ser Ser Ala Lys Ile 145 Gin Lys Lys Ser Gly 225 Phe Phe Tr Ile Lys Leu Asp Val Tyr Asn Ala 130 Glu Asn Ile Lys G ly 210 Met Pro Asp His Leu 290 Asn Ala 35 Glu Lys Phe Leu Phe 115 Gin Leu Lys Ile Ala 195 Ser Phe Leu Lys Giu 275 IGiu Ile 20 Gln As n Phe Ser Ile 100 Leu Asn Val1 Phe Ala 180 Leu Met Ser Ala Giy 260 Lys Lys 5 Val Giu Ser Leu Giu Ala Vai Leu Val1 His 165 Sen Giu Vai *Tyr *Leu 245 *Vai Sen His Ile Ile Ser Glu 70 G iu Tyr G ly Val1 Ala 150 Phe dly G iy Ala Pro 230 Met Lys G lu Leu Giu Leu Giy Giu Lys Asp Thr Ala 135 Leu Ile Gly Phe Asp 215 Gin Val Lys Cys Lys 295 Ile G1u 40 Asp Thn Giu Pro Ile 120 Ser Glu Glu Asn Phe 200 Val Lys Glu Arg Tyr 280 Glj Ile 25 Lys Thr Phe Thr Leu 105 Ile Leu G lu Thr Gin 185 Ala His Lys Lys Leu 265 Leu Glu Tyr 10 Ser Pro Pro Leu Pro 90 Asp Gly Tyr Val Ile 170 Lys Giu His Leu Ala 250 Leu Ala Lys Arg Phe Leu Leu Glu Asp Ala Gly Ile Lys Ala Ser Leu Glu 75 Val Thr Lys Gly Ser Ser Val Tyr Glu 125 Val Val Phe 140 Tyr Ang Tyr 155 Val Leu Giu Asp Phe Ser Asn Tyrn Arg 205 Val Leu Val 220 Ang Lys Leu 235 Lys Giy Giu Asp Gin Sen Sen Pro His 285 L~ys Lys S er Asn G iu Val1 110 Lys Gly Ala Asn Leu 190 Leu Lys Phe Ala Val1 270 Glu Gly Gly Tyr Leu Val1 Asn Met Asp His Phe Lys 175 G iy Arg Lys Giu Phe 255 Glu Ala Lys Val1 Thr Ala Lys Gly Giu Tyr Lys Tyr 160 Gly Leu Tyr Gly Val1 240 Tyr Ser Gin 1136 INFORMATION FOR SEQ ID NO:i585: SEQUENCE CHARACTERISTICS: LENGTH: 263 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION 1. 263 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1585 0.
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S S *5*e o S. S. S
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55 S S Thr Val Leu Phe Ile 65 Ala Leu Asn Gly Phe 145 Asn Gin Ile Phe Ile 225 Thr Val Giu Ile 35 Gly Sen Leu Gly Asn 115 Gin Pro Ile Ala Val 195 Phe Ala Lys Tyr Leu 20 Ser Ala Gin Gly Phe 100 Tyr Giu Asn Asn Gly 180 C lu Asn Gly Asn Val1 260 Ser Met Giy Lys Phe Asn Ile Met Asn 165 Asn Gin Vai Val1 Leu 245 Phe Met Lys Asn Ala Tyr Leu 55 Gin Ala 70 Gin Phe Asp Tyr Ser Giu Asn Ang 135 Leu Thn is0 Gly Ile Ser Trp Ala Leu Gly Ala 215 Lys Phe 230 Asp-le Thr Phe Lys Val 40 Gin Thr Phe Ala Ala 120 Leu Tyr Met Leu Val1 200 Ang Pro Gly 10 Phe Gly Gin Ala Giu 90 Ala Gin Asn Giy Leu 170 Ala Lys Arg Leu Ser Met Ala Thr 75 Lys Asn Val Ile Ala 155 Gly Thr Lys Ile Lys 235 Phe Leu Ile Ile Phe Trp Val Phe Phe Leu Arg Gln Asp Gin Ile His Ser Ala Ala 140 Met Ala Pro Ala Leu 220 Lys Ile Ser Gly Met Lys Phe Ile Ser 125 Asp Asp Phe Sen Thr 205 Lys As n Lys Leu Asn His Gly Gly Lys 110 Gin Pro Val1 Gly Phe 190 Ser His Pro His Tyr Leu Ala Gly Val Ala Asp Phe Asp Leu Arg Leu Lys Ile Leu Ang Thr Met Val 160 Gly Ile 175 Giu Gly Phe Gin Ser Sen Tyr Ile 240 Trp Tyr 255 Phe Arg Arg Val Tyr Ser 250 INFORMATION FOR SEQ ID NO:1586: SEQUENCE CHARACTERISTICS: LENGTH: 234 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein 1137 (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE-.
NAME/XEY: misc-feature LOCATION .234 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1586
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9 1 Trp Ile Lys Leu Lys Giu Asp Val Asp Leu 145 Asn Met Pro Asp Giu 225 Ile Ile Lys Giu Ile
LYS
Ile Arg Gly 130 Leu Val Lys Asn Val1 210 Ala Asp Tyr Arg Pro Ile Ala Ala 115 Arg Asn Gly Val Leu 195 Val Leu Ile Ile 40 Tyr Arg Met Asn Val 120 Thr Asn Leu Ile Sen 200 Ala Ile His Asp Ile Leu Ile Asn As n Thn Ser 155 G ly Val Met Asp.
Asp Ala Lys Asn Lys Giu Giu Ala Ile Ile Gin Ser Val1 Giu Ala Giu Leu Phe 125 Sen Ser Ser Leu Gin 205 Asn Gly Giu Lys Giu Leu Thn Thr 110 Lys Giu Leu Giu Ile 190 Ala Ser INFORMATION FOR SEQ ID NO:i587: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 295 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY misc-feature LOCATION .295 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1S87 Lys Lys Lys Thr Leu. Asn Ile Ser Gin Leu Gly Lys Thr Met His Val 1138 1 5 10 Ala Cys Leu Leu Ala Leu Gly Asp Asn Leu Ile Thr Leu Ser Leu Leu 25 Lys Glu Ile Ala Ser Lys Gin Gin Gin Ser Leu Lys Ile Leu Gly Thr 40 His Leu Thr Leu Lys Ile Ala Lys Leu Leu Glu Cys Glu Lys His Phe 55 Glu Ile Ile Pro Val Phe Glu Asn Ile Pro Ala Phe Tyr Asp Leu Lys 70 75 Lys Gin Gly Val Phe Trp Ala Met Lys Asp Phe Leu Trp Leu Leu Lys 90 Ala Ile Lys Lys His Gin Ile Lys Arg Leu Ile Leu Glu Lys Gin Asp 100 105 110 Phe Arg Ser Phe Leu Leu Ser Gin Phe Val Ser Ile Thr Thr Pro Asn 115 120 125 Lys Glu Ile Lys Asn Val Tyr Gin Asn Arg Gin Glu Leu Phe Ser Gin 130 135 140 Ile Tyr Gly His Val Phe Asp Asn Pro Pro Tyr Pro Met Ser Leu Lys 145 150 155 160 Asn Pro Lys Lys Ile Leu Ile Asn Pro Phe Thr Arg Glu Asn Asp Arg 165 170 175 Asn Ile Ser Leu Glu His Leu Lys Ile Val Leu Lys Leu Leu Lys Pro 180 185 190 Phe Cys Val Thr Leu Leu Asp Phe Glu Glu Arg Tyr Ala Phe Leu Lys 195 200 205 Asp Arg Val Ala His Tyr Arg Ala Lys Thr Ser Leu Glu Glu Val Lys 210 215 220 Asn Leu Ile Leu Glu Ser Asp Leu Tyr Ile Gly Gly Asp Ser Phe Leu 225 230 235 240 Ile His Leu Ala Tyr Tyr Leu Lys Lys Asn Tyr Phe Ile Phe Phe Tyr 245 250 255 Arg Asp Asn Asp Asp Phe Met Pro Pro Asn Ser Gly Asn Glu Asn Phe 260 265 270 Leu Lys Ala His Lys Ser His Phe Ile Glu Gin Asp Leu Ala Lys Lys 275 280 285 Phe Arg His Leu Gly Leu Leu 290 295 INFORMATION FOR SEQ ID NO:1588: S. SEQUENCE CHARACTERISTICS: LENGTH: 68 amino acids TYPE: amino acid 9 TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...68 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1588 Asn Thr Gin Arg Gin Thr Leu Pro Leu Val Lys Ser Arg Pro His Pro 1 5 10 Leu Val Lys Ile Tyr Leu Lys Gin Met Cys Gly Met Gly Phe Ile Gly 25 Phe Lys Thr Lys Leu Thr Gin Thr Lys Ala Phe Ile Ile Leu Ile Pro 40 1139 Ie Phe Gin Asp Arg Ala Val Lys Ala Ala Thr Arg Ser Ala Pro Ile so 55 Gin Leu Ile Cys INFORMATION FOR SEQ ID NO:15B9: SEQUENCE CHARACTERISTICS: LENGTH: 1413 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NA.ME/KEY: misc-feature LOCATION .1413 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1589 'p 0 0**0 p. p p p.
p Thr Thr Asn Ala Leu 65 Asn Ile Gly Thr Ser 145 Ser Gin Asn Thn Phe 225 Ser Thn Ile Gin Leu Ile Ser Thr Ile Asp 20 Phe Asn Asn 35 Pro Ser Leu so Gly Asn Asn Ile Thr Lys Thr Gly Ile 100 Met Lys Ile 115 Trp Ser Phe 130 Ile Lys Asn Ala Ser Asn Asp Ser Lys 180 Gin Ala Gly 195 Pro Lys Gly 210 Asn Gin Pro Glu Asn Leu Leu Lys Giu 260 Asn Glu Val 275 Lys Gin Ala 290 Gin Thn Phe Ile Phe Sen Ala Ser Gin Ala Asp 5 Thr Leu Thn Gly Ser Ser Gin Ile Gly Thr 165 Gin Thr Ser Leu Lys 245 Met Leu Leu Asn Ala Thr Lys Asp 70 Val1 Gly Asn Asn1 Asp 150 Ile Asn Gin Asn 230 Thn Ile Gin Leu Asn Ser Ala Ala 55 Ile Thr Ala Ala Pro 135 Leu Phe Pro Tyr -Thr 215 Ser Leu Glu Leu Glu 295 Gly Phe Asn 40 Leu Tyn Asn Thr 120 Leu Thr Asn Thn Leu 200 Pro Leu Leu Sen Leu 280 Thr Asn Asn 25 Gly Met Leu Asn G ly 105 Tyr Asn Ile Ile Gly 185 Thr Gin Asn Gly Asn 265 Asp Ile Leu 10 Phe Ala Asn Ser Ile 90 Tyr Ser Ser Giu Ala 170 Tyr Sen Thr Ile Ile 250 Gin Lys Asn Val A~sp Leu Val Asp 75 Leu Glu Asp Ser Val 155 Pro Ser Asn Pro Tyr 235 Leu Leu Ile His Ile Ser Asn Ser Ile Asn Lys Asn Gin 140 Leu Glu Tyr Ile Gly 220 Asn Ser Asp Lys Leu 300 Gly Phe Ala Phe Gly Asn Ala Ile Asn 125 Ile Asn Leu Asp Lys 205 Thr Lys Gin Asn Ile 285 Thr Ala Gly Ser Asn GAn Ile Gln Leu 110 As n Ile Asn Tyr Tyr 190 Gly Tyr Gly Asn Ile 270 Thr Asp Thn Gly Ser Gly Phe Phe Lys Phe Ile Gin Pro Asn 175 Ser Leu Sen Phe Ser 255 Thr Gin Asn Gin As n Leu Tyr Val Asp Gly Tyr Gin Glu Asn 160 Tyr Asp Phe Pro Ser 240 Ala Asn Ala Ile Asp 1140 *0 00 *0 0 9* 0000 0 0 305 Asn Val Thr Ser Ser Pro Thr Ty Leu 355 Ile Asn Ala 370 Gly Ser Ser 385 Gin Ser Ala Ala Thr Asp Ile Phe Asn 435 Giu Lys Ile 450 Leu Ser Pro 465 Leu Gly Gin Ser Gly Val Ile Phe Gly 515 Lys Gin Ser 530 Ile Gly Gly 545 Ile Leu Lys Gly Val Vai Val Lys Lys 595 Val Ile Ser 610 Ser Val Leu 625 Gly Thr Leu Tyr Phe Asn Phe Ser Asn 675 Ile Ile Phe 690 Ala Leu Ile 705 Leu Asn Ala Ser Val Gin Thr Lys Asn 755 Ser Leu Ser 770 Ser Asn Gly 785 Gly Thr Leu Thr Ile Thr Asn Cys 340 Gly Asp Asn Asn Asn 420 Gin Lys Leu Leu Met 500 Asn Leu Tyr Asp Ala 580 Leu Gin Pro Leu Phe 660 Ala Asn Phe Thr Lys 740 Ser Val1 Ala Asn As n 820 Ser 325 Ala Gin Phe Ala Asn 405 Ile Gly Gin Ser Ile 485 Asn Phe Lys Ile Ile 565 Asn Glu Gly Pro Ser 645 Leu Thr Gly Ala Asn 725 G ly Ser His Ile Leu 805 Ala 310 Thr Ser Leu Asp Leu Leu Lys Ala 375 Phe Giu 390 Leu Val Phe Asn Asn Leu Ala Gly 455 Lys Giu 470 Gly Gin Glu Ile Val Thr Ser Met 535 Asp Ala 550 Thr Asn Asp Leu Ser Gin Gly Leu 615 Ser Leu 630 Pro Arg Ser Asn Gly Gly Asp Asn 695 Ser Asn 710 Gly- Leu Giu Ile Pro Ala Ala Asn 775 Asp Leu 790 Asn Glu Phe Asn ser Ser Gly 360 Lys Ser Leu Leu Ala 440 Gly Leu Asn Gin Pro 520 Leu Ser Pro Leu Gly 600 Ser Gin Gly Gly Ser 680 Thr Gly Ser Cys As n 760 Asn Ser Asn Asn Ile Ala 345 Ser Ser Gly Asn Leu 425 Asn Leu Pro As n Asn 505 Ser Asp Giu Pro Asn 585 Leu Gly Asm Leu 665 Leu Ile Val1 Leu Ile 745 Ser Phe Gin Ala Ala 825 Trp 330 Thr Thr Ile Gly Lys 410 Gly Val1 Gly Ala Leu 490 Ile Ile Asp Leu Thr 570 Glu Val Val1 Ala His 650 Val1 Asn Asp Ser Asn 730 Asn Ser Thr Val1 Thr 810 Ser Asn Phe 350 Leu Gly Val1 Giu Ile 430 Met Giu Asp Leu Lys 510 Tyr Leu Leu Lys Gin 590 Ile Gly Asn Gin Asn 670 Asn Tyr Ile Asn Cys 750 Thr Thr Ser Asn Ala 830 Gly 335 Axg Gly Thr Thr Ala 415 Asp Ala Asn Glu Asn 495 Leu Leu Asn Gly Asp 575 Asp Asri Leu Asp Lys 655 Ser Lys Gin Thr Asn 735 Pro Asn Ile Val1 Asn 815 Asn 1141 Asp Gly Asn Phe Thr Leu Asn Gin Gin Ala Thr Leu Ser Thr Asn Ala 835 840 845 Ser Giy Leu Asn Val Met Giy Asn Phe Asn Ser Tyr Gly Asp Leu Val 850 855 860 Phe Asn Leu Ser His Ser Val Ser His Ala Ile Ile Asn Thr Gin Gly 865 870 875 880 Tbr Ala Thr Ile Met Ala Asn Asn Asn Pro Leu Ile Gin Phe Asn Aia 885 890 895 Ser Ser Pro Giu Val Gly Thr Tyr Thr Leu Ile Asp Ser Ala Lys Ala 900 905 910 Ile Tyr Tyr Gly Tyr Asn Asn Gin Ile Thr Gly Gly Ser Ser Leu Asp 915 920 925 Asn Tyr Leu Lys Leu Tyr Ala Leu.Ile Asp Ile Asn Gly Lys His Met 930 935 940 Val Met Thr Asp Asn Gly Leu Thr Tyr Asn Gly Gin Ala Val Ser Val 945 950 955 960 Lys Asp Gly Gly Leu Val Val Gly Phe Lys Asp Ser Gin Asn Gin Tyr 965 970 975 Ile Tyr Thr Ser Ile Leu Tyr Asn Lys Val Lys Ile Ala Val Ser Asn 980 985 990 Asp Pro Ile Asn Ash Pro Gin Ala Pro Thr Leu Lys Gin Tyr Ile Ala 995 1000 1005 Gin Ile Gin Gly Val Gin Ser Val Asp Ser Ile Asp Gin Ala Gly Gly 1010 1015 1020 Asn Gin Ala Ile Asn Trp Leu Asn Lys Ile Phe Glu Thr Lys Gly Ser 1025 1030 1035 1040 Pro Leu Phe Ala Pro Tyr Tyr Leu Giu Ser His Ser Thr Lys Asp Leu 1045 1050 1055 Tbr Thr Ile Ala Gly Asp Ile Ala Asn Thr Leu Giu Val Ile Ala Asn 1060 1065 1070 *Pro Asn Phe Lys Asn Asp Ala Thr Asn Ile Leu Gin Ilie Asn Thr Tyr *Gn1075 1080 1085 Thr GiGn Met Ser Arg Leu Ala Lys Leu Ser Asp Thr Ser Thr Phe 1090 1095 1100 Ala Arg Ser Asp Phe Leu Giu Arg Leu Giu Ala Leu Lys Asn Lys Arg 1105 1110 1115 1120 *Phe Ala Asp Ala Ile Pro Asn Ala Met Asp Val Ile Leu Lys Tyr Ser 1125 1130 1135 Gin Arg Asn Arg Val Lys Asn Asn Val Trp Ala Thr Giy Val Gly Gly 1140 1145 1150 *Ala Ser Phe Ile Ser Gly Gly Thr Gly Thr Leu Tyr Gly Ile Asn Val 1155 1160 1165 Gly Tyr Asp Arg Phe Ile Lys Gly Val Ile Val Gly Gly Tyr Ala Ala 1170 1175 1180 Tyr*. Gly Tyr Ser Gly Phe His Ala Asn Ile Thr Gin Ser Gly Ser Ser 1185 1190 1195 1200 Asn Val Asn Val Giy Val Tyr Ser Arg Ala Phe Ile Lys Arg Ser Glu 1205 1210 1215 Leu Thr Met Ser Leu Asn Giu Thr Trp Gly Tyr Asn Lys Thr Phe Ile 1220 1225 1230 Asn Ser Tyr Asp Pro Leu Leu Ser Ile Ile Asn Gin Ser Tyr Arg Tyr 1235 1240 1245 Asp Thr Trp Thr Thr Asp -Ala Lys Ile Asn Tyr Gly Tyr Asp Phe Met 1250 1255 1260 Phe Lys Asp Lys Ser Val Ile Phe Lys Pro Gin Val Gly Leu Ser Tyr 1265 1270 1275 1280 Tyr Tyr Ile Gly Leu Ser Gly Leu Arg Gly Ile Met Asp Asp Pro Ile 1285 1290 1295 Tyr Asn Gin Phe Arg Ala Asn Ala Asp Pro Asn Lys Lys Ser Val Leu 1300 1305 1310 Thr Ile Asn Phe Aia Leu Glu Ser Arg His Tyr Phe Asn Lys Asn Ser 1315 1320 1325 Tyr Tyr Phe Val Ile Ala Asp Val Gly Arg Asp Leu Phe Ile Asn Ser 1330 1335 1340 Met Gly Asp Lys Met Val Arg Phe Ile Gly Asn Asn Thr Leu Ser Tyr 1142 1345 1350 1355 1360 Arg Asp Gly Gly Arg Tyr Asn Thr Phe Ala Ser Ile Ile Thr Gly Gly 1365 1370 1375 Glu Ile Axg Leu Phe Lys Thr Phe Tyr Val Asn Ala Gly Ile Gly Ala 1380 1385 1390 Arg Phe Gly Leu Asp Tyr Lys Asp Ile Asn Ile Thr Gly Asn Ile Gly 1395 1400 1405 Met Arg Tyr Ala Phe 1410 INFORMATION FOR SEQ ID NO:i590: SEQUENCE CHARACTERISTICS: LENGTH: 193 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .193 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1590 *Arg Asp Asn Met Glu Leu Ile Leu Gly Ser Gin Ser Ser Ala Arg Ala 1 5 10 Asn Leu Leu Lys Glu His Gly Ile Lys Phe Glu Gin Lys Ala Leu Tyr 25 Phe Asp Glu Giu Ser Leu Lys Thr Thr Asp Pro Ang Glu Phe Val Tyr .9.35 40 Leu Ala Cys Lys Gly Lys Leu Giu Lys Ala Lys Glu Leu Leu Ala Asn 55 Asn Cys Ala Ile Val Val Ala Asp Sen Val Val Ser Val Gly Asn Arg 70 75 Met Gin Axg Lys Ala Lys Asn Lys Ang Giu Ala Leu Glu Phe Leu Lys 90 Ang Gin Asn Gly Asn Giu Ile Glu Val Leu Thr Cys Ser Ala Leu Ile :::100 105 110 Sen Pro Val Leu Glu Trp Leu Asp Leu Ser Val Phe Arg Ala Arg Leu 115 120 125 Lys Ala Phe Asp Cys Sen Glu Ile Giu Lys Tyr Leu Glu Sen Gly Leu 130 135 140 Trp Gin Gly Sen Ala Gly Cys Val Ang Leu Glu Asp Phe His Lys Pro 145 150 155 160 Tyr Ile Lys Sen Ser Sen L-ys Asn Leu Sen Val Gly Leu Gly Leu Asn 165 170 175 Val Glu Gly Leu Leu Gly Ala Leu Lys Leu Gly Val Lys Leu Ser Leu 180 185 190 Leu INFORMATION FOR SEQ ID NO:1591: SEQUENCE CHARACTERISTICS: LENGTH: 168 amino acids TYPE: amino acid TOPOLOGY: linear 1143 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...168 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1591 Arg Met Ala Leu Phe Gly Ser Lys Ser Lys Met Leu Glu Thr Tyr Ala 1 5 10 Leu Lys Ser Gly Ala Val Phe Ile Ser Asp Ala His Phe Leu Pro Lys 25 Ser Pro His Leu Ile His Thr Leu Lys Glu Leu Leu Ser Ala Lys Pro 40 Pro Gin Val Phe Phe Met Gly Asp Ile Phe His Val Leu Val Gly Tyr 55 Leu Pro Leu Asp Lys Glu Gin Gln Lys Ile Ile Asp Leu Ile His Ala 70 75 Leu Ser Glu Ile Ser Gin Val Phe Tyr Phe Glu Gly Asn His Asp Phe 85 90 Ser Met Arg Phe Val Phe Asn Ser Lys Val Met Val Phe Glu Arg Gin 100 105 110 Asn Gin Pro Ala Leu Phe Gin Tyr Asp Asn Lys Arg Phe Leu Leu Ala 115 120 125 S His Gly Asp Leu Phe Ile Thr Lys Ala Tyr Glu Phe Tyr Ile Thr Gin 130 135 140 SLeu Thr Ser Thr Trp Ala Arg Phe Phe Leu Thr Phe Leu Asn Leu Leu 145 150 155 160 Ser Phe Lys Thr Leu Tyr Pro Phe 165 INFORMATION FOR SEQ ID NO:1592: SEQUENCE CHARACTERISTICS: LENGTH: 320 amino acids TYPE: amino acid TOPOLOGY: linear S- (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...320 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1592 Asn Asp Asp Glu Asn Lys Val Ile Glu Leu Lys Thr Arg Asn Asn Met 1 5 10 Arg Ile Val Phe Met Gly Thr Pro Ser Phe Ala Glu Val Ile Leu Arg 25 Ala Leu Val Glu Asn Glu Asp Lys Lys Ile Glu Val Val Gly Leu Phe 40 Thr Gln Arg Asp Lys Pro Phe Gly Arg Lys Lys Glu Leu Lys Ala Pro
I
1144 55 Glu Thr Lys Thr Tyr Ile Leu Glu Asn His Leu Asn Ile Pro Ile Phe 70 75 Gin Pro Gin Ser Leu Lys Glu Pro Glu Val Gin Ile Leu Lys Gly Leu 90 Lys Pro Asp Phe Ile Val Val Val Ala Tyr Gly Lys Ile Leu Pro Lys 100 105 110 Glu Val Leu Thr Ile Ala Pro Cys Ile Asn Leu His Ala Ser Leu Leu 115 120 125 Pro Lys Tyr Arg Gly Ala Ser Pro Ile His Glu Met Ile Leu Asn Asp 130 135 140 Asp Arg Ile Tyr Gly Ile Ser Thr Met Leu Met Asp Leu Glu Leu Asp 145 150 155 160 Ser Gly Asp Ile Leu Glu Ser Ala Ser Phe Leu Arg Glu Asp Tyr Leu 165 170 175 Asp Leu Asp Ala Leu Ser Leu Lys Leu Ala Arg Met Gly Ala Thr Leu 180 185 190 Leu Leu Ser Thr Leu Lys Asn Phe His Ser Ile Thr Arg Lys Pro Gin 195 200 205 Asp His Met Gin Ala Ser Phe Cys Lys Lys Ile Ala Lys Ala Asp Gly 210 215 220 Leu Val Gly Phe Lys Asp Ala Lys Asn Leu Phe Leu Lys Ser Leu Ala 225 230 235 240 Phe Lys Ser Trp Pro Glu Ile Phe Leu Glu Asn Ser Leu Lys Leu Leu 245 250 255 Glu Val Glu Leu Val Glu Asn Glu Lys Ser His Lys Glu Gly Glu Ile 260 265 270 Leu Ala Ile Asp Glu Arg Gly Val Leu Val Gly Cys Leu Lys Gly Ser 275 280 285 Val Arg Iie Ala Arg Leu Gin Ala Val Gly Lys Lys Pro Leu Lys Ala 290 295 300 Lys Asp Tyr Leu Asn Gly Arg Arg Leu Lys Val Gly Gly Ile Leu Thr 305 310 315 320 INFORMATION FOR SEQ ID NO:1593: SEQUENCE CHARACTERISTICS: LENGTH: 171 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori
FEATURE:
NAME/KEY: misc_feature LOCATION 1-..171 {xi) SEQUENCE DESCRIPTION: SEQ ID NO:1593 Lys Ser Thr Arg Lys Thr Ile Met Glu Ala Gin Leu Arg Phe Thr Gly 1 5 10 Val Gly Gly Gin Gly Val Leu Leu Ala Gly Glu Ile Leu Ala Glu Ala 25 Lys lie Val Ser Gly Gly Tyr Gly Thr Lys Thr Ser Thr Tyr Thr Ser 40 Gin Val Arg Gly Gly Pro Thr Lys Val Asp Ile Leu Leu Asp Lys Asp 55 Glu Ile Ile Phe Pro Tyr Ala Lys Glu Gly Glu Ile Asp Phe Met Leu 70 75 1145 Ser Val Ala Gin Ile Ser Tyr Asn Gin Phe Lys Ser Asp Ile Lys Lys 90 Gly Gly Ile Val Val Ile Asp Pro Asn Leu Val Thr Pro Thr Lys Glu 100 105 110 Asp Glu Glu Lys Tyr Gin Leu Tyr Lys Ile Pro Ile Ile Ser Ile Ala 115 120 125 Lys Asp Glu Val Gly Asn Ile Ile Thr Gin Ser Val Val Ala Leu Ala 130 135 140 Ile Thr Val Glu Leu Thr Lys Cys Val Glu Glu Asn Ile Val Leu Asp 145 150 155 160 Thr Met Leu Lys Lys Val Pro Cys Lys Ser Arg 165 170 INFORMATION FOR SEQ ID NO:1594: SEQUENCE CHARACTERISTICS: LENGTH: 428 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...428 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1594 Ala Cys Leu Lys Gin Glu Asn Ile Thr Asn Thr Gln Ile Leu His Ile 1 5 10 Gly Asp Asn Ser Trp Ala Asp Asp Ala Met Pro Lys Ser Leu Gly Ile 25 Ala Thr Leu Phe Arg Lys Ser Val Leu Lys Gin Leu Glu Glu Val Phe 35 40 Pro Lys Tyr Lys Thr Phe Asn Pro Thr Ser Val Ala Gin Ser Phe Ile 55 Leu Gly Ser Leu Cys Val Phe Tyr Lys Asn Tyr Ile Gin Lys His Glu 70 75 Lys Phe Asp Tyr Trp Phe Leu Leu Gly Ala Met Gin Ala Gly Ile Ala 90 Ala Val Ala Tyr Cys Gin Phe Ile Tyr Lys Glu Ile His Lys Arg Asn 100 105 110 Ile Asp Thr Leu Val Phe Val Ala Arg Asp Gly Tyr Leu Leu Gin Lys 115 120 125 Ile Phe Asn Ile Leu Tyr Pro Asn Ser Tyr Lys Thr Thr Tyr Val Tyr 130 135 140 Ala Pro Arg Ile Leu Lys Lys Ala Val Phe Leu Glu Val Val Glu Gly 145 150 155 160 Glu Ser Leu Glu Ile Leu Arg Ile Leu Glu Gly Glu Glu Glu Val Lys 165 170 175 Lys Lys Gin Ile Thr Thr Asn Gin Gin Ala Tyr Val Tyr Leu Tyr Ser 180 185 190 Asn Phe Glu His Cys Arg His Leu Ala Leu Lys Cys Leu Asp Asn Tyr 195 200 205 Arg Lys Tyr Leu Phe Ser Ser Asn Leu Glu Gly Asn Ile Ala Ile Val 210 215 220 Asp Thr Ile Thr Leu Gly Tyr Ser Ser Gin Gly Leu Ile Gin Lys Ala 225 230 235 240 Leu Asn Lys Glu Val Phe Gly Cys Tyr Val Asp Leu Leu Arg Ile Leu 1146 Asn Tyr Val 305 Giu Leu Pro Asp Leu 385 Arg Leu Phe Pro 290 Ser Gly Asp Ser Ala 370 Leu Ser Ile Cys 260 Asn Leu Cys Vai His 340 Gin His Cys Arg Lys 420 245 Vali Trp Asn Giu Gly 325 Asp Asp Lys Ile Thr 405 Ile Se r Asp Vai Lys 310 Tyr Val Gin Asn Leu 390 Asn Tyr Phe Phe Giu 295 His Aia Ile Giu Aia 375 Lys Lys Gly Leu Met 280 Asn Arg Ser Giu Gin 360 Leu Pro Gin Lys Lys 270 Ser Gin Lys Gin Ile 350 Phe Asp Val1 Ile Pro Pro Lys Ile Ile 335 Asp Leu Vai Leu Leu 415 a
S
a. a.
S
.a S a.
a .aa.
*a INFORMATION FOR SEQ ID NO:i595: SEQUENCE CHARACTERISTICS: LENGTH: 375 amino acids TYPE: amino acid TOPOLOGY: iinear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Heiicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .375 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i595 Gly Leu Leu Ala Cys Leu Leu Val Leu Leu Asn Leu 1 Asn Trp Ile Val Asp Phe Ser Trp Asn Sen Ile Ser Ile 100 Gly Pro Leu Phe Tnp Asnr Trp Trp Ile Phe Tyr iso Asp G ly Asn His Trp Giy Ser 135 Lys Aia Arg Val1 Ser Vali Leu 125 Phe Ser Leu Met Phe Val Ile Tnp Aia Giy Gly His His Leu Ile Tyr 155 160 1147 Ser Thr Val Pro Asp Trp Val Gin Thr Leu Ser Ser Val Phe Ser Val 165 170 175 Val Leu Ile Leu Pro Ser Trp Gly Thr Ala Ile Asn Met Leu Leu Thr 180 185 190 Met Arg Gly Gin Trp His Gin Leu Lys Glu Ser Pro Leu Ile Lys Phe 195 200 205 Leu Val Leu Ala Ser Thr Phe Tyr Met Leu Ser Thr Leu Glu Gly Ser 210 215 220 Ile Gin Ala Ile Lys Ser Val Asn Ala Leu Ala His Phe Thr Asp Trp 225 230 235 240 Ile Ile Gly His Val His Asp Gly Val Leu Gly Trp Val Gly Phe Thr 245 250 255 Leu Ile Ala Ser Met Tyr His Met Thr Pro Arg Leu Phe Lys Arg Glu 260 265 270 Ile Tyr Ser Gly Arg Leu Val Asp Phe Gin Phe Trp Ile Met Thr Leu 275 280 285 Gly Ile Val Leu Tyr Phe Ser Ser Met Trp Ile Ala Gly Ile Thr Gin 290 295 300 Gly Met Met Trp Arg Asp Val Asp Gin Tyr Gly Asn Leu Thr Tyr Gin 305 310 315 320 Phe Ile Asp Thr Val Lys Ala Leu Ile Pro Tyr Tyr Asn Ile Arg Gly 325 330 335 Val Gly Gly Leu Met Tyr Phe Ile Gly Phe Ile Ile Phe Ala Tyr Asn 340 345 350 Ile Phe Met Thr Ile Thr Ala Gly Lys Lys Leu Glu Arg Glu Pro Asn 355 360 365 Tyr Ala Thr Pro Met Ala Arg we 370 375 INFORMATION FOR SEQ ID NO:1596: SEQUENCE CHARACTERISTICS: LENGTH: 301 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...301 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1596 Gly Phe Asp Asp Asp Met Glu Ile Arg Asn Ile Lys Glu Phe Glu Lys 1 5 10 Ala Ser Lys Lys Leu Gin Lys Asp Thr Leu Lys Ile Ala Leu Ala Leu 25 Leu Phe Leu Ile Gly Ala Ala Leu Leu Ala Leu Ile Phe Gly Gin Ala 40 Asn Ser Lys Gly Leu Leu Leu Ile Phe Ala Ala Val Ile Gly Gly Tyr 55 Met Ala Met Asn Ile Gly Ala Asn Asp Val Ser Asn Asn Val Gly Pro 70 75 Ser Val Gly Ser Lys Ala Ile Ser Met Gly Gly Ala Ile Leu Ile Ala 90 Ala Val Cys Glu Met Leu Gly Ala Ile Ile Ala Gly Gly Glu Val Val 100 105 110 Ser Thr Ile Lys Gly,Arg Ile Val Ser Pro Glu Phe Ile Asn Asp Ala 1148 His Trp 145 Ser Ser Ile Ile Lys 225 Tyr Ile Phe Giu Val1 130 Leu Val Ala Ser Lys 210 Val Leu Gin Lys Ser 290 Met 135 Leu Met Phe Ala 215 Val Leu Cys Lys Phe 295 120 Leu Ile C ly Leu Leu 200 Lys Ala Lys Val Lys 280 Asn Ala Gly Ala Ser 185 Ile Giu Leu Arg Leu 265 Ala Val1 Leu Leu 140 Pro Val 155 Met Ala Ile Val Met Phe Lys Lys 220 Ser Leu 235 Tyr Ala Leu Leu Gin Leu Leu Ile 300 125 Ser Ser Ala Ala Phe 205 Ser Ala Val1 Ile Glu 285 Phe Gly Thr Ala Ser 190 Leu Ala Phe Gly Phe 270 Asn b.
a a. a a a. a a a a.
a INFORMATION FOR SEQ ID NO:1597: SEQUENCE CHARACTERISTICS: LENGTH: 432 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyiori (ix) FEATURE: NAME/KEY: misc -feature LOCATION .432 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1597 Arg Met Lys Leu Lys Lys Thr Leu Thr 1 Phe Leu Giu Asp Thr Thr Lys Leu Glu Asn 40 Asp Gly Ser Gly Pro 120 Lys Gin His His Ala Giu Asn Pro Lys Tyr Ala Pro Leu Giu Leu Lys Asn Gly Thr Asn Gly 75 Leu Asp Leu Asn Ile Asp Asp Lys 110 Leu Glu Leu Tyr 125 Tyr Phe Ile Met Tyr Ser Giu Ile Ile Ala Tyr Phe Lys Thr Lys Lys His Ile Ser Asp Giu Val Ser Ser His Ala Ile Val Gin Lys Arg Ile Ala Gly Leu Asp Phe 145 '.150 155 1149 Leu Lys Ile Leu Thr Asn Ile Thr Ser Asp His Leu Asp Phe His Gin 165 170 175 Asn Ile Glu Asn Tyr Arg Asp Ala Lys Asn Ser Phe Phe Lys Asp Glu 180 185 190 Gly Leu Lys Val Ile Asn Arg Asp Glu Thr Asn Ala Leu Phe Asn Pro 195 200 205 Ile Asn Ala Arg Thr Tyr Ala Leu Asp Lys Lys Ala His Leu Asn Val 210 215 220 Gin Ala Phe Ser Leu Asn Pro Ser Ile Ser Ala Ser Leu Cys Tyr Gin 225 230 235 240 His Asp Leu Arg Asp Pro Asn Leu Lys Glu Thr Ala Leu Ile His Ser 245 250 255 Pro Leu Leu Gly Arg Tyr Asn Leu Tyr Asn Ile Leu Ala Gly Val Leu 260 265 270 Gly Val Lys Leu Leu Thr Gin Leu Pro Leu Glu Thr Ile Ala Pro Leu 275 280 285 Leu Glu Asn Phe Tyr Gly Val Lys Gly Arg Leu Glu Ile Val His Ser 290 295 300 Lys Pro Leu Val Val Val Asp Phe Ala His Thr Thr Asp Gly Met Gin 305 310 315 320 Gin Val Phe Glu Ser Phe Lys Asn Gin Lys Ile Thr Ala Leu Phe Gly 325 330 335 Ala Gly Gly Asp Arg Asp Lys Thr Lys Arg Pro Lys Met Gly Ala Ile 340 345 350 Ala Ser Cys Tyr Ala His Gin Ile Ile Leu Thr Ser Asp Asn Pro Arg e. 355 360 365 Ser Glu Asn Glu Glu Asp Ile Ile Lys Asp Ile Leu Lys Gly Ile Asn 370 375 380 S* Asn Ser Ser Lys Val Ile Val Glu Lys Asp Arg Lys Lys Ala Ile Leu 385 390 395 400 Asn Ala Leu Glu Asn Leu Lys Asp Asp Glu Val Leu Leu Ile Leu Gly 405 410 415 Lys Gly Asp Glu Asn Ile Gin Ile Phe Lys Asp Lys Thr Ile Phe Phe 420 425 430 INFORMATION FOR SEQ ID NO:1598: SEQUENCE CHARACTERISTICS: LENGTH: 327 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY:_misc_feature LOCATION 1...327 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1598 Arg Leu Leu Ser Gin Phe Lys Thr Arg Ile Asn Met Gin Glu Phe Ser 1 5 10 Leu Trp Cys Asp Phe Ile Glu Arg Asp Phe Leu Glu Asn Asp Phe Leu 25 Lys Leu Ile Asn Lys Gly Ala Ile Cys Gly Ala Thr Ser Asn Pro Ser 40 Leu Phe Cys Glu Ala Ile Thr Lys Ser Ala Phe Tyr Gin Asp Glu Ile 55 Ala Lys Leu Lys Gly Lys Lys Ala Lys Glu Ile Tyr Glu Thr Leu Ala 1150 70 75 Leu Lys Asp Ile Leu Gin Ala Ser Ser Ala Leu Met Pro Leu Tyr Glu 90 Lys Asp Pro Asn Asn Gly Tyr Ile Ser Leu Glu Ile Asp Pro Phe Leu 100 105 110 Glu Asp Asp Ala Ile Lys Ser Ile Asp Glu Ala Lys Arg Leu Phe Lys 115 120 125 Thr Leu Asn Arg Pro Asn Val Met Ile Lys Val Pro Ala Ser Glu Ser 130 135 140 Ala Phe Glu Val Ile Ser Ala Leu Ala Gin Ala Ser Ile Pro Ile Asn 145 150 155 160 Val Thr Leu Val Phe Ser Pro Lys Ile Ala Gly Glu Ile Ala Gin Ile 165 170 175 Leu Ala Lys Glu Ala Arg Lys Arg Ala Val Ile Ser Val Phe Val Ser 180 185 190 Arg Phe Asp Lys Glu Ile Asp Pro Leu Val Pro Gin Asn Leu Gin Ala 195 200 205 Gin Ser Gly Ile Met Asn Ala Thr Glu Cys Tyr Tyr Gin Ile Asn Gin 210 215 220 His Ala Asn Lys Leu Ile Ser Thr Leu Phe Ala Ser Thr Gly Val Lys 225 230 235 240 Ser Asn Ser Leu Ala Lys Asp Tyr Tyr Ile Lys Ala Leu Cys Phe Lys 245 250 255 Asn Ser Ile Asn Thr Ala Pro Leu Asp Ala Leu Asn Ala Tyr Leu Leu 260 265 270 Asp Pro Asn Thr Glu Cys Gin Thr Pro Leu Lys lie Thr Glu Ile Glu 275 280 285 Ala Phe Lys Lys Glu Leu Lys Thr His Asn Ile Asp Leu Glu Asn Thr 290 295 300 Ala Gin Lys Leu Leu Lys Glu Gly Leu Ile Ala Phe Lys Gin Ser Phe 305 310 315 320 Glu Lys Leu Leu Ser Ser Phe 325 INFORMATION FOR SEQ ID NO:1599: SEQUENCE CHARACTERISTICS: LENGTH: 358 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...358 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1599 Gly Phe Lys Val Arg Leu Phe Arg Phe Val Gly Trp Tyr Tyr Phe Lys 1 5 10 Tyr Phe Leu Ile Val Leu Leu Ala Leu Glu Leu Phe Phe Val Gly Ile 25 Asp Ser Leu Lys Tyr Ala Asp Lys Met Pro Asp Ser Ala Asn Met Ile 40 Ile Leu Phe Phe Thr Tyr Asp Ile Leu Phe Ala Leu Asn Tyr Thr Leu 55 Pro Ile Ser Leu Leu Leu Ala Met Val Leu Phe Tyr Ile Thr Phe Ile 70 75 1151 Lys Ser Asn Gin Tyr Thr Ala Leu Leu Gin Tyr Gin Leu 145 Leu Thr Giu Thr 225 Lys Val Phe Tyr Leu 305 Leu Leu Ile Val Asn 130 Val Leu Leu Tip Leu 210 Leu Pro Arg Ala Phe 290
LYS
Giy Ser Leu Gly 115 Leu
LYS
Gin Giu Ile 195 dly
LYS
Ala Gin Ile 275 Ser Phe Lys Pro Ser 100 Leu Ile Tyr.
Lys Ser 180 Leu Ala Asn Val Asn 260 Leu Pro Ile Phe Phe 340 Pro Asn Tyr Asn Ala 165 Tyr His Asn Phe Ser 245 Ala Pro Ser Ile Ser 325 Phe Ile Ala Lys Asp 150 Gin Ala Asp Ala Arg 230 Ile Asp Phe Leu Ile 310 Ile Phe Thr Asp 135 Asp Asn Glu Thr Leu 215 Pro Thr Thr Phe Ala 295 Thr Ser Leu Pro 120 Asn Ile Ala Thr 200 Asn Lys Asp Lys Val1 280 Arg Leu Giy Ile 105 Phe Ser Vai Lys Lys 185 Ile Thr Val1 Ala Lys 265 Pro Tyr Val Ile Ser Ile Ser Leu Val Tyr Leu Ser Tyr Phe 155 Val Phe 170 Glu Ala Tyr Glu Thr His Leu Asp 235 Leu Leu 250 Val Arg Phe Leu Giu Asn Val Trp 315 Leu Ile Gly Phe Met Val 140 Asp Arg Phe Met Leu 220 Thr Ser Ser Ser Leu 300 Gly Pro Phe Phe Giu 125 Ser Lys Leu Phe Pro 205 Giu Ile Leu Phe Val 285 Ala Leu Glu Ser Thr 110 Glu Glu Ile Lys Glu 190 Leu Thr Tyr His Leu 270 Leu Leu Phe Ile Lys Ala Lys His Asn Asp 175 Asp Ser Phe Gin Ala 255 Tyr Ile Leu Phe Gly 335 Cys Val1 Thr Leu Pro 160 Lys Lys Phe Lys Asn 240 Leu Val1 Ala Gly Ala 320 Val1
S
*5 S S .SS S Val Phe Leu Ala Leu Ser Leu Trp Tyr Phe Lys 350 Lys Leu Asn 355 Lys Arg Leu INFORMATION FOR SEQ ID NO:1600: SEQUENCE CHARACTERISTICS: LENGTH: 459 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAM'E/KEY: misc-feature LOCATION .459 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:lEOO Lys Arg Arg Val Val Lys Phe Tyr Thr Tyr Ser Gly Glu Thr Ala Ala 1 5 10 Glu Ala Leu Lys Ile Ala Gin Sen His His Gly Val Asp Thr Leu Val 25 Phe Lys Thr Gin Giu Ile Arg Lys Lys Thr Leu Thr Ser Ser Gly Leu 40 Tyr Glu Ile Val Val-Ala Val Giu Glu Glu Giu Asn Lys Lys Ala Pro 1152 Leu Val Val Leu Gin Glu Leu Asn 100 Asp Leu
I
Glu Arg *ft 145 Asn Met Phe His Met 225 Arg Arg Leu Lys Gin 305 Ile Asp Lys Val Ile 385 Lys Glu Ala Phe Ala Leu 210 Arg Lys Ile Ala Val 290 Leu Asp Phe Ile Ser 370 Tyr Leu Ser Glu Lys Gin Leu Trp Asp 180 Glu Ile 195 Asp Glu Glu Asn Ile Ile Leu Met 260 Lys Leu 275 Gly Ile Ser Trp Ala Lys Ile Leu 340 Ala Gly 355 Leu Val Asp Ser Asp Glu Gin Lys 420 Leu Lys 435 Phe Ser Ser Ser G1n Ala Leu Arg Ser 165 Glu Tyr Ile Ser Leu 245 Leu Ala Ile Tyr Asp 325 Val Leu Leu Phe Ser 405 Pro Val Asn Leu 70 Ser Arg Pro Gin Glu 150 Lys Lys Lys Met Val 230 Cys Val Ala Thr Ala 310 Phe Asp Lys Ser Gly 390 Arg Ile Ala Pro Tyr Thr Asn Leu Ala 135 Val Ile Asn Leu Gin 215 Thr Arg Gly Arg Leu 295 Asn Ala Thr Glu Val 375 Val Gly Ser Thr Asn 455 Asp Val Tyr Glu 120 Leu Lys Arg Pro Ala 200 Leu Ile Pro Pro Tyr 280 Asp Lys Lys Thr Phe 360 Thr Leu Leu Tyr Asn 440 Lys Glu Glu Thr 105 Asp Lys Gin Asp Asn 185 Lys Ser Lys Glu Thr 265 Ser Asn Met Glu Gly 345 Ile Thr Gly Gly Leu 425 Glu Glu Glu Glu 90 Phe Thr Asp Glu Ser 170 Ser Gin Leu Arg Asp 250 Gly Arg Tyr Lys Ile 330 His Asp Lys Ile Asn 410 Ser Tyr Gln Leu 75 Met Ser Pro Glu Glu 155 Leu Val Ser Glu Tyr 235 Leu Val Met Arg Met 315 Glu Ser Gly Tyr Asp 395 Leu SVal SLeu Ala Asn Arg Lys Leu Ala 140 Glu Lys Asn Gly Leu 220 Phe Asn Gly Leu Ile 300 Ser Ala Gin Gly Glu 380 Thr Phe Gly Val Glu Lys Asn Glu 125 Asn Ile Leu Ile Met 205 Met Arg Leu Lys Ala 285 Gly Ile Leu Tyr Tyr 365 Asp Leu Ser Gin Asp 445 Glu Leu Lys 110 Ala His Lys Ile Pro 190 Lys Pro Glu Arg Thr 270 Lys Ala Glu Glu Asp 350 Asn Met Ile Leu Glu 430 Cys Asp Ala Thr Asn Lys Asp Gin 175 Gin Ser Leu Val Gin 255 Thr Lys Leu Ala Tyr 335 Lys Ile Lys Phe Val 415 Val Met Val Gly Leu Lys Lys Ile 160 Asn Glu Ser Arg Leu 240 Lys Thr Tyr Glu Val 320 Cys Glu Asp Asp Thr 400 His Pro Leu Met Asp Asp Gly 450 INFORMATION FOR SEQ ID NO:1601: SEQUENCE CHARACTERISTICS: LENGTH: 355 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: 1153 ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...355 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1601 Ile Met Ala Asp Ile Leu Ser Gin Glu Glu Ile Asp Ala Leu Leu Glu 1 Val Val Asp Ile Pro Gin go.o o 0 0 *.f
C*
*0f C Val Ala Glu Met Met Met Arg 145 Gin Tyr Val Gly Glu 225 Thr Gly Leu Lys Tyr 305 Lys Met Ser Arg Ile Ser Gly Ile 130 Glu Val Pro Ala His 210 Ser Asn Val Lys Val 290 Leu Glu Leu Lys Asn Gin Leu Gly 115 Asp Phe Met Thr Gin 195 Ser Ile Ser Ser Glu 275 Ala Ala Val Glu 5 Glu Asn Arg Ser Glu Gin Leu Ser Leu His Pro Ser 100 Thr Gly Arg Leu Ser Asp Gin Ile 165 Ile Asp 180 Asn Glu Arg Gly Leu Ser Lys Lys 245 Val Asp 260 Met Leu SAsn Asp Ser Val SVal Tyr 325 Val Val Leu Ser 70 Ser Pro Val Leu Ile 150 Leu Ala Ile Met Lys 230 Ser Met Asp Glu Gly 310 Sei Asp Thr Arg 55 Gin Val Thr Leu Gly 135 Glu Lys Lys Ser Met 215 Met Arg Met Leu SVal 295 SPhe Glu Ile Leu 40 Ser Val Asp Ser Glu 120 Gly Leu Glu Glu Ile 200 Asn Gly Asn Val Asp 280 Ser Gin Lys Gin 25 Tyr Phe Ser Gin Phe 105 Ile Lys Asn Val Ser 185 Met Ile Ser Lys Phe 265 Val Val Gly Glu 10 Asn Asp Arg Ser Met 90 Asn Asn Gly Leu Trp 170 Ser Val Cys Arg Glu 250 Leu Gly Tyr STyr SArg 330 Val Val Phe Ser Ile 75 Thr Val Pro Ser Leu 155 Ser Ala Val Tyr Asp 235 Letu Gly Asp Val Arg 315 Thr Gly Gin Lys Ile Met Tyr Phe Ser Ala 140 Asp Pro Asn Leu Pro 220 Phe SGin Ala Thr His 300 Lys Lys SAsp Lys Arg His Arg Gly Ser Ile 125 Tyr Thr Val Val Glu 205 Val Met Ala Val Ile 285 Lys Thr Glu Ile Lys Pro Asp Ser Glu Met 110 Ala Asp Ile Val Val 190 Ile Ile Leu Leu Glu 270 Arg Lys Ile Ile Met 350 Asp Asn Lys Ile Phe Lys Phe Gin Leu Glu 175 Gin Ile Ser Ser Leu 255 Leu Leu Lys Gin Leu 335 Lys Ile Arg Met Val Leu Pro Pro Asn Arg 160 Met Ile Ile Ile Glu 240 Ser Ser Asn Arg Ile 320 Glu Ile I Glu Gln Arg Arg Gly Lys 340 345 Glu Glu Glu 355 INFORMATION FOR SEQ ID NO:1602: SEQUENCE CHARACTERISTICS: LENGTH: 297 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein 1.154 (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .297 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i602 G1y Thr Ser Met Ser Asn Gin Ala Ser His Leu As
-L
Ala Ile Ala Phe Lys Gin Lys Ala Asn Asp Thr Glu Asn Ile Leu Ala His Ile 5 Pro Lys Thn Ser Ala Tyr Asp Ile Lys Asn 85 Ile Cys 100 Giu Giu Val Asp Thr Gly Asp Cys 165 Ala Tyr.
180 Leu Ile 10 Ser Phe Phe Asp Asn Asp Sen Gly 115 Asp Arg Phe 130 Val Ile Asp 145 Asn Ala Ser Ile Thn Asp Giu Leu Phe 195 Ala Thr Tyr 210 Leu Giu Leu 225 Arg Tyr Val Leu Phe Ser Leu Glu Thr 275 Phe Lys Arg 290 Gly Ser G ly 70 Ile Giu Ile Glu Ala 150 Val Ala Ala Lys Gi1 25 y Gly Val *Leu Tlyr Lys 55 Leu Ala Asn Leu His Ala Ile Giu Pro 105 Leu Lys Tyr 120 Giu Gly Val 135 Gly Ile Gly Val Ile Val Cys Ile Lys 185 Asn Met Val 200 Phe Lys Val 215 Gly Ala Ile LYS Ile Leu Leu Leu 90 G iy Ile Leu Ala Thr 170 Ile Ala Ala Glu krg IAsp Val 75 *Lys Gly *Leu Cys Sen Giy Ser Ser 140 Thr Thr 155 Thr Pro Asn Ser Gin Pro Lys Asn.
220 Asn Ser 235 Lys Ile Ile Giu Leu Ala 125 Leu Gin Asp Lys Lys 205 Asn Se r Phe Ala Ilie Glu Asp Ala Pro Asn 190 Giu Ile Leu Gly Lys Pro Ala Tyr Phe Ser 175 Lys dly Ala Leu Asn 255 Ser I Sen
P
Val Leu Gly Leu Ile Leu 160 Ala Asp k.rg 3er -'ys ~*p 'he Lys Gly Gly Lys Asn Phe Met Asn is Asn Thr Lys Phe Ser Asn Ile Ser Lys Gly Tyr Lys Val Gly Val Giu His Arg Gin Ang Leu Tyr Leu 230 Glu Ang Sen Ile Asp Gin Ile Gly Thn Leu Leu Leu Lys Giu Tyr 295 265 Pro Gdy Ala Ser Leu Leu Val 270 Lys Giu Gly Leu Lys 285 INFORMATION FOR SEQ ID NO:i603: SEQUENCE
CHARACTERISTICS:
LENGTH: 531 amnino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori 1155 (ix) FEATURE: NAME/KE: miscfeature LOCATION 1...531 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1603 Ile 1 Asn Glu Tyr Gin Lys Lys Ser Ala His 145 Leu Lys Leu Leu Met 225 Cys Glu Asn Glu Thr 305 Ser Ala Glu Gir Asr 385 G17 Let Glt Lyr Ser C Thr Gin I Val Ile Asp Asn Ser Leu 130 Ser Pro lie Glu Glu 210 Thr Glu Glu Arg Ala 290 Arg Lys Pro Pro Val 370 Asp ITyr a Asn a Ser Asn Ele .ys ys ,eu Ile Tyr Ala 115 Glu Val Gly Met Leu 195 Ala Ile Arg Tyr Glu 275 Ala Ala Lys Leu Leu 355 Gin Gin Gin Tyr Leu 435 His ?he L'yr Jal GIn rhr Leu 100 Lys Tyr Leu Phe Glu 180 Ala Lys His Leu Asp 260 Val Lys Glu Glu Glu 340 Met Glu Glu Tyr His 420 Glu Ala 5 Lys I Pro I Ser I Glu Ile Gin Leu Ala Lys Asn 165 Gin Val Glu Lys Gly 245 Gly Val Asp Leu Ser 325 Glu Thr Ile Ala Ala 405 Tyr Leu Leu .ys ys .eu kla 70 Leu 31u Ser Leu Leu 150 Pro Phe Gly Ile Ser 230 Asn Thr Asp His Gly 310 Lys Gly Ser Glu Ile 390 Tyr Gly Phe Lys Ala Thr Val 55 Gin Cys Tyr Gin Ala 135 Ala 4 Lys Lys Cys Ala 215 Lys Pro Glu Lys Glu 295 Leu Asn Glu Val Glu 375 Asn Asn Phe Glu Gly ryr( ;er Z 10 klal ksnI kla Leu Leu 120 Glu Giy Lys Leu Glu 200 Ser Gly Asn Leu Asp 280 Glu Ile Lys Ile Va1 360 Glu Phe Ile Tyr Asn 440 Glu ;In Z 5 ksn ksp Leu rhr Ser 105 al Glu Tyr Glu Tyr 185 Asp Phe Met Ser Ala 265 Tyr Ile Val Lys Ala 345 Ile Ser Gl Pro Gl) 425 As; Al 10 Asn Asn I Glu I Leu Asn I 90 Ala Glu Pro Leu Ser 170 Glu 4 Ala.
Asn Gin Ser 250 Arg Ala Asn Val Met 330 Pro Lys Asp Ile Lys 410 Leu Ala k Ala er .ys ys ;lu 75 iys Ile Ser Tyr His 155 al G1u Asp Pro Phe 235 His Leu Arg Val Ala 315 His Val Pro Ser Ala 395 Gin Asp Glj Phe Pro His Glu His Asp.
Arg Lys Lys 140 Asp Ala Pro Gly Lys 220 Pro Ala Tyr Ala Tyr 300 Lys Glu Ile His Asp 380 Leu Ser 4Tyr Ile Leu Thr Val Leu Arg Ala Pro Ile 125 Pro Asp Ser Ala Phe 205 Gly Tyr Asn Tyr Leu 285 Tyr Asp Gin Ser Ala 365 Tyr His Val Gin Gin 445 Phe Ala Thr Leu Ile Leu Ser 110 Ile Phe Val Phe Gin 190 Leu Ala Val Gin Arg 270 Asp Val Lys Leu Pro 350 Tyr Glu Lys Leu Ala 430 Ala Gir Tyr Glu Leu Asp.
Glu Thr Lys.
Tyr Ile Val 175 Ser Glu Gin Ile Leu 255 Met Lys Ala Lys Glu 335 Gin Gly Lys Gly Glu 415 Leu Leu Gly Leu Gly lu Pro Ile Glu Asn Lys Ala 160 Trp Cys Lys Ile Val 240 Leu Lys Glu Phe Glu 320 Leu Lys Glu Asn Leu 400 Tyr Glu Phe Val 1u Phe Asn His Arg Ser Ala Pro Leu Ile Ile Asn Tyr Val 450 455 460 Val Ser Arg Ile Asp. Val Leu Leu Trp Asp Arg Gly Gin Asn Leu Tyr 1156 465 470 475 480 Val Leu Asp Tyr Lys Ser Ser Gin Asn Tyr Gin Gin Ser His Lys Ala 485 490 495 Gin Val Ser His Tyr Ala Glu Phe Leu Arg Thr Gin Ala Pro His Phe 500 505 510 Lys Ile Gin Ala Gly Ile Ile Tyr Ala His Lys Arg Leu Leu Glu Lys 515 520 525 Leu Trp Val 530 INFORMATION FOR SEQ ID NO:1604: SEQUENCE CHARACTERISTICS: LENGTH: 253 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...253 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1604 Leu Ser Thr Ala Tyr Gin Ala Val Glu Leu His Trp Phe Leu Lys Ala 1 5 10 Val Leu Val Leu Glu Arg Ser Pro Ser Ser Pro Glu Ile Lys Gly Ile 25 Trp Asp Arg Asp Tyr His Thr Pro Ile Thr Ser Ser Phe Thr Leu Asp 35 40 Val Ser Tyr Asp Asn Thr Asp Asp Tyr Tyr Phe Pro Arg Asn Gly Val 50 55 Ile Phe Ser Ser Tyr Ala Thr Met Ser Gly Leu Pro Ser Ser Gly Thr 70 75 Leu Asn Ser Trp Asn Gly Leu Gly Gly Asn Val Arg Asn Thr Lys Val 90 Tyr Gly Lys Phe Ala Ala Tyr His His Leu Gin Lys Tyr Leu Leu Ile 100 105 110 Asp Leu Ile Ala Arg Phe Lys Thr Gin Gly Gly Tyr Ile Phe Arg Tyr 115 120 125 Asn Thr Asp Asp Tyr Leu Pro Leu Asn Ser Thr Phe Tyr Met Gly Gly 130 135 140 Val Thr Thr Val Arg Gly Phe Arg Asn Gly Ser Ile Thr Pro Lys Asp 145 150 155 160 Glu Phe Gly Leu Trp Leu-Gly Gly Asp Gly Ile Phe Thr Ala Ser Thr 165 170 175 Glu Leu Ser Tyr Gly Val Leu Lys Ala Ala Lys Met Arg Leu Ala Trp 180 185 190 Phe Phe Asp Phe Gly Phe Leu Thr Phe Lys Thr Pro Thr Arg Gly Ser 195 200 205 Phe Phe Tyr Asn Ala Pro Thr Thr Thr Ala Asn Phe Lys Asp Tyr Gly 210 215 220 Val Val Gly Ala Gly Phe Glu Arg Ala Thr Trp Arg Ala Ser Thr Gly 225 230 235 240 Leu Gin Ile Glu Trp Ile Ser Pro Met Gly Pro Trp Cys 245 250 1157 INFORMATION FOR SEQ ID NO:1605: SEQUENCE CHARACTERISTICS: LENGTH: 86 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...86 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1605 Ala Arg Ile Met Leu Asp Lys Arg Ile Lys Thr Leu Leu Leu Phe Phe 1 5 10 Gly Leu Asn Met Val Cys Leu Ser Val Ser Phe Thr Asn Lys Pro His 20 25 Leu Cys Phe Trp Phe Leu Val Leu Gly Cys Tyr Leu Val Tyr Glu Trp 40 Gin Lys Lys Gln Lys Lys Asp Phe Gin Ser Ala Lys Ser Leu Lys Phe 50 55 Asp Ser Val Ser Glu Leu Glu Lys Asp Leu Asn Met Glu Val Thr Asn 70 75 Asp Glu Trp Asp Thr His
S
S
INFORMATION FOR SEQ ID NO:1606: SEQUENCE CHARACTERISTICS: LENGTH: 272 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...272 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1606 Ser Arg Ser Val Glu Met Asn Tyr Pro Asn Leu Pro 1 5 10 Glu Ile Ser Glu Gin Pro Glu Val Lys Glu Ile Thr 25 Lys Gin Leu Gin Asn Ala Leu Arg Ser Asn Ala His 40 Val Glu Leu Ser Leu Lys Cys lle Val Arg Ile Leu 55 Ser Leu Asp Phe Phe Lys Asn Ala Asn Glu Ile Asp 70 75 Asn Ser Ile Glu Trp Leu Thr Asn Ala Gly Glu Ser Asn Asn Phe Glu Ser Leu Ser Ala Leu Glu Leu Leu Ser Glu Gin Val Leu Leu Ser Leu Arg Lys Leu Lys 1158 Met Lys Giu Ala Ile Thr 145 Asn Ile Thr Giu Lys 225 Asn Ala Giu 115 Ser Leu Asn Gin Ala 195 Ser Ser Ile Lys 100 Gin Giu Leu Asn Ala 180 Ile Asn Ala Thr Thr 260 Giu Ile Thr Gin 165 Lys Thr Asn Thr Gin 245 Asp Va 1 Lys Ser 150 Ile Asn Asn Gin Thr 230 Giu His Thr Lys 135 Tyr Thr Asn Ile Thr 215 Gin Lys Tyr As n 120 Leu Gin Lys Ala Thr 200 Gin Ile Thr Gin 105 Thr Giu Ile Asn Asn 185 Glu Ala Asn Gin Asn 26S Leu Asn Phe Lys 170 Asn Ala Ile Ala Ala 250 Ile Giu Arg Phe Phe Ser Giu Phe Asn Gin Leu 155 Thr Giu Lys Thr Asn 235 Thr Asp As n Ala Leu 140 Asn Gin Ile Thr Asn 220 Lys Ser Phe Thr Asn 125 Ile Gin Ser Ser Asn 205 Ile Gin Glu Phe Ser 110 Ala Giu Ala Leu As n 190 Ala Asn Glu Ile Glu 270 Met Giu Thr Arg Giu 175 Thr Asn Giu Ala Thr 255 Phe His Asn Thr Asp 160 Ala Gin Asn Ala Ile 240 Giu Glu
S*
S.
S
S
*5SS a S S. *5SS
S
*5S*
S.
S S INFORMATION FOR SEQ ID NO:1607: SEQUENCE CHARACTERISTICS: LENGTH: 443 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .443 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1607 Gly Leu Sen Val Leu Giu Arg Tyr Ala Asn Glu Glu Met Lys Ala Leu 1 Trp Val Giu Ile Ala Sen Leu Asn Gly 145 Asn Val s Giu Giu Ser Lys Arg 130 Giu Arg Ile Lys Ser Asp Leu 115 Ala Lys Phe Asn Lys Lys-Ala Lys His 70 Glu Glu Asp Thr Lys Gly His Gin 13S Glu Thr Leu Gly 40 Ala Phe Asp Leu Ser Arg Ala Met 105 Val Lys 120 Asp Thr Val Asp Arg Thr Tyr Met Giu 125 G ly Giu Sen Ile Thn Gly Thr 110 Thr Arg Lys Asp Lys Cys Ile Lys Leu Sen Ala Cys Glu Val1 Thr Sen Lys His Val Phe Gly Giu Pro Ile Thr Phe Gly Leu Val Leu Ala Leu Phe 1- 150 iss 160 1159 Ala Phe Ala Thr Leu 225 Val Ala Asn Ser Asp 305 Ile Leu Gly Leu Ile 385 Leu Asn Asp Ile Pro Ala 210 Ala Asn Phe Pro Phe 290 Met Thr Val Leu Ser 370 Trp Phe Glu Glu Ser Leu 195 Asn Cys Ile Ser Ile 275 Thr Ser Ser Val Val 355 Arg Glu Leu Ser Ile Val 180 Glu Ile Asp Arg Ala 260 Leu Thr His Asp Tyr 340 Phe Glu Val Asn Glu Lys Arg His 165 Trp Ala Ile Leu Glu Glu Ser Asn Gln 215 Leu Ala Leu 230 His Leu Gin 245 Gly Gin Lys Ser Glu Asn Pro Met Leu 295 Ser Ser Val 310 Phe Met Leu 325 Pro Lys Asn Ser Gln Arg Glu Ser Tyr 375 Leu Gin Gin 390 Ala Leu Leu 405 Ile Arg Ala Ile Phe Lys Leu Ser Leu 200 Val Leu Arg Gly Ile 280 Glu Glu Ser Met Val 360 Ser Gly Asn Cys Arg 440 Lys Gly 185 Ala Ile Ala Ser Ser 265 Thr Asn Arg Arg Leu 345 Leu Ile Ala Asp Phe 425 Val Ala 170 Gly Cys Gln Ser Glu 250 Ser Gly Val Phe Leu 330 Lys Leu Val Phe Glu 410 Asp Phe Leu Leu Gly Arg Ser 235 Val Ala Leu Ala Ala 315 Asn Asn Glu Gin Lys 395 SArg Tyr Gly Asp Gly Phe Asp 220 Cys Tyr Met Cys Leu 300 Leu Ser Leu Leu Glu 380 Asn Leu Ser Leu Asn Leu 205 Arg Glu Glu Pro Arg 285 Trp Pro Val Ala Pro 365 Asn Ala Lys Tyr Thr Phe 190 Gly Tyr Lys Val His 270 Val His Asp Ile Leu 350 Lys Ala Asp Lys Tyr 430 Met 175 Ala Leu Ala Ile Glu 255 Lys Ile Glu Leu Glu 335 Ser Lys Met Glu Tyr 415 Thr Glu His Lys Arg Ala 240 Glu Arg Arg Arg Phe 320 Asn Gly Gly Lys Asn 400 Leu Lys
S
S
Asn Val Gly Ala 435 INFORMATION FOR SEQ ID NO:1608: SEQUENCE CHARACTERISTICS: LENGTH: 97 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...97 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1608 Asn Asp Ser Gly Ser Lys His Phe Ile Leu Pro Phe Leu Thr Leu Leu 1 5 10 Leu Gin Met Tyr Leu Ser Arg Thr Arg Glu Tyr Met Ala Asp Ser Gly 25 Ala Ala Phe Leu Met His Asp Asn Lys Pro Met Ile Arg Ala Leu Gin 40 Lys Ile Ser Asn Asp Tyr Thr Asn Asn Asp Tyr Lys Glu Ile Asp Lys I 1160 55 Asn Ser Thr Arg Ser Ala Ala Tyr Leu Phe Asn Ala Glu Met Phe Ser 70 75 Thr His Pro Ser Ile Lys Asn Arg Ile Gin Ser Leu Arg Lys Arg Val 90 Ile INFORMATION FOR SEQ ID NO:1609: SEQUENCE CHARACTERISTICS: LENGTH: 180 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori S(ix)
FEATURE:
NAME/KEY: misc_feature LOCATION 1...180 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1609 Met Glu Lys Phe Phe Asn Gin Phe Phe Glu Asn Ile Gly Glu Asp Lys 1 5 10 Asn Arg Glu Gly Leu Lys Glu Thr Pro Lys Arg Val Gin Glu Leu Trp 20 25 Lys Phe Leu Tyr Lys Gly Tyr Lys Glu Asp Pro Arg Val Ala Leu Lys 40 Ser Ala Tyr Phe Gin Gly Val Cys Asp Glu Met Ile Val Ala Gin Asn 55 Ile Glu Phe Tyr Ser Thr Cys Glu His His Leu Leu Pro Phe Phe Gly 70 75. Asn Ile Ser Val Gly Tyr Ile Pro Lys Glu Lys Ile Val Gly Ile Ser 85 90 SAla Ile Ala Lys Leu Ile Glu Ile Tyr Ser Lys Arg Leu Gin Ile Gin 100 105 110 Glu Arg Leu Thr Thr Gin Ile Ala Glu Thr Phe Asp Glu Ile Ile Glu 115 120 125 Pro Arg Gly Val Ile Val Val Cys Glu Ala Lys His Leu Cys Met Ser 130 135 140 Met Gin Gly Val Gin Lys Gin Asn Ala Ile Ile Lys Thr Ser Val Leu 145 150 155 160 Arg Gly Leu Phe Lys Lys Asp Pro Lys Thr Arg Ala Glu Phe Met Gin 165 170 175 Leu Leu Lys Ser 180 INFORMATION FOR SEQ ID NO:1610: SEQUENCE CHARACTERISTICS: LENGTH: 308 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES 1161 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NA121E/KEY: misc-feature LOCATION .308 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:16i0 Val Giu Giu Asn Ser Lys Asp Thr Ala Sen 145 Ile Thr Ala Ile Met 225 Asp Ser Thr Lys 305 Ile Cys Gly Gly Leu Ile Asp Leu Leu 130 Arg Lys Pro Lys Asn2 210 Gly Giu Phe LeuI Leu 290 GlyI Ile Leu Gly Met Ser Asn Pro Asn Leu Ser Phe G iu Phe Gdy Val1 Ala Leu His 115 ks n Ile 31Y eu .jeu 195 ksp eu 'ys; lai ys; er .ys Ang His
LYS
Gly Leu Pro 100 Ala Thr Ile Met Asn 180 Ile Giu Cys Giu Asn 260 Thn Leu Thr
S
Phe Pro Ang Lys Sen Cys Lys Tyr Val Ile 165 Leu Sen Glu Phe Ser 245 Leu Giu Gin 10 Glu Sen Tyr Leu Phe Ang 55 Lys Asp Ile Giu Met Asp Tyr Asp Sen Phe 135 Glu Leu 150 Leu Gly Giu Gin Ala Sen Leu Leu 215 Gin Val 230 Gly Lys Leu Gly Ile Leu Giu Asn 295 Phe Leu 25 Giu Lys 40 Pro Lys Tyr Ser Cys Leu Asn Ala 105 Giu Thr 120 Giu Leu Val Lys Gin Ala Leu Thr 185 Leu Ile 200 Lys Trp Leu Asp Thr Thr Leu Lys 265 Asn Asp 280 Leu Asn Lys Ala Leu Asn His 90 Ile Thr Leu Ile Leu 170 Phe Met Leu Asp His 250 Lys Leu Ala Asn Phe Phe Gin 75 Thr Leu Ala Sen Leu 155 Asp Leu dly Gin Ile 235 Leu Ala Asn Leu *His Phe Leu Gin Tyr Arg Val1 Asri 140 Ser Cys His Leu Ala 220 Ile Asp Ser Ala Leu 300 Tyr Giu Ala Thr Ser Arg Leu 125 Sen Ala Glu Val1 205 Phe Asp Sen Giy Leu 285 Asn Tyr Leu Met Val G iu Leu Asn 110 Ile Leu Asn Phe His 190 Ala Gly Val1 Ala Tyr 270 Giu Thr Cys is His Val1 Leu Tyr Ile His Gly Leu Giy Giu 175 Lys Sen Leu Thr Lys 255 Ala Pro Leu Asn Leu Leu Cys Phe His Pro Asp Giu Gly 160 As n Thr Gly Lys Gin 240 Asn Gin Thr Phe
INFORMATION
FOR SEQ ID NO:1611: (i) (vi) SEQUENCE CHARACTERISTICS: LENGTH: 347 amino acids TYPE: amino acid TOPOLOGY: linear MOLECULE TYPE: protein HYPOTHETICAL: YES ORIGINAL. SOURCE: ORGANISM: Helicobacter pylori 1162 (ix) FEATURE: NAME/KEY: misc-feature LOCATION .347 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1611 Leu Asn Thr Ser Lys Lys Lys Arg Asn Leu Asn Leu 1 Cys Arg Arg Phe Gly Thr Gin Asp Leu 145 Tyr Glu Asp Arg Ile 225 Arg Gin Arg Asp Thr 305 Ala Asn Leu Lys Leu Ile Ile Ile Asn Pro 130 Leu Ile Ser Arg His 210 Met Lys Ile Thr Asn 290 Asn Arg Lys Giu Lys Gly Aia Val Phe 115 Ser G iu Ile Asn Asp 195 Asn Leu Asn Ile Arg 275 Lys Asn Leu Ile Giy Lys Thr Leu Leu Met 100 Ser Lys Leu Asn Ser 180 Giu Asp Leu Ser Leu 260 Giu Pro Asp Phe Gin 340 5 Vali Ile Asn Leu Phe Phe Ser Val Leu Ala 165 Leu Leu Ile Val Gly 245 Pro Tyr Met Asn 325 Ser Met Met Ala Val1 70 Lys Val1 Ile Leu Glu 150 Pro Ile Lys Arg Ala 230 Ala Phe Met Ile Lys 310 Ala Leu Arg Thr Val 55 Asp Leu Val Met Ser 135 Glu Tyr Ala Ala Leu 215 Asn Asn Leu Ala Arg 295 Giu Glu Arg Ala Arg 25 Asn Phe 40 Leu Thr Ala Ile Met Thr Ala Phe 105 Leu Ser 120 Ser Lys Ala Lys Met Asn Leu Thr 185 Val Ile 200 Thr Met Phe Ser Leu Ala Thr Leu 265 Asp Ser 280 Ala Leu Ile Asp Met Phe Lys Arg 345 Lys Ile Cys Asn Ile Ile Glu Gin 140 Phe Ala Leu Giu Gly 220 Phe Ile Gin Ala Ile 300 Ser His Trp Lys Ile Ala Ala Phe Leu Tyr 125 Ile Giu Ser Ile Leu 205 Ile Phe Leu Met Phe 285 Ser Thr Pro Asn Ser Ala Ile Asn Pro Val1 110 Lys His Pro Gly Glu 190 Ser Leu Met Trp Tyr 270 Leu Asn Arg Ser Phe Ser Gin Phe Asp Thr Cys Leu Arg Lys Trp 175 Arg His Ser Gly Val 255 Leu Met Asp Ser Ile 335 Thr Met Asn Aia Leu Ile Ile le Leu Leu 160 Asp Leu le Asn Asn 240 Leu Ser His Tyr Ala 320 Lys INFORMATION FOR SEQ ID NO:1612: SEQUENCE CHARACTERISTICS: LENGTH: 65 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) (vi) HYPOTHETICAL: YES ORIGINAL SOURCE: 1163 ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...65 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1612 Thr Gin Pro His Lys Asn Lys Arg Leu Asn Lys Arg Leu Asn Lys Arg 1 5 10 Leu Asn Lys Arg Leu Asn Lys Arg Leu Asn Lys Arg Leu Asn Lys Arg 25 Leu Asn Lys Lys Leu Asn Lys Ser Lys Lys Lys Lys Ile Ser Leu Asn 40 Lys Thr Val Ser Arg Pro Phe Lys Thr Ile Lys Lys Pro Pro Gin Pro 55 Pro INFORMATION FOR SEQ ID NO:1613: SEQUENCE CHARACTERISTICS: LENGTH: 138 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...138 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1613 Gly Val Asn Met Leu Ile Leu Gly His Pro Leu Ile Pro Ser Ala Arg 1 5 10 Phe Val Phe Ile Lys Asn Thr Asp Ala Ile His Ser Ser Ala Asn Asn 25 Asp Ile Val Cys Phe Glu Ala Asn Pro Lys Asn Leu Glu Leu Ala Gin 40 Tyr Cys Cys Glu Asn Gly Val His Phe Ser Val Ile Phe Leu Ser His 55 Lys Ile Glu Thr Asp Thr Phe Phe Leu Phe Asn Ala Phe Lys Pro Leu 70 75 Tyr Cys Ile Phe Lys Asp Ile Lys Gin Ala Ile Leu Ala Gin Gin His -90 Ala Thr Asn Tyr Leu Leu Asp Ser Lys Ile Leu Phe Ser Met Asp Phe 100 105 110 Asn Asp Thr Glu Ser Trp Glu Ile Cys Ala Lys Asn Gin Ile Asp Gly 115 120 125 Val Ile Ser Lys Asp Ser Leu Leu Leu Lys 130 135 INFORMATION FOR SEQ ID NO:1614: SEQUENCE CHARACTERISTICS: LENGTH: 134 amino acids TYPE: amino acid 1164 TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...134 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1614 Phe Lys Cys Asn Leu Lys Arg Arg Ser Ala Leu Lys Leu Leu Val Val 1 5 10 Asp Asp Ser Ser Thr Met Arg Arg Ile Ile Lys Asn Thr Leu Ser Arg 25 Leu Gly Tyr Glu Asp Val Leu Glu Ala Glu His Gly Val Glu Ala Trp 40 '0,0 Glu Lys Leu Asp Ala Asn Ala Asp Thr Lys Val Leu Ile Thr Asp Trp 50 55 Asn Met Pro Glu Met Asn Gly Leu Asp Leu Val Lys Lys Val Arg Ala 65 70 75 Asp Asn Arg Phe Lys Glu Ile Pro Ile Ile Met Ile Thr Thr Glu Gly 85 90 Gly Lys Ala Glu Val Ile Thr Thr Leu Lys Ala Gly Val Asn Asn Tyr 100 105 110 Ile Val Lys Pro Phe Thr Pro Gln Val Leu Lys Glu Lys Leu Glu Val 115 120 125 Val Leu Gly Thr Asn Asp 130 INFORMATION FOR SEQ ID NO:1615: SEQUENCE CHARACTERISTICS: LENGTH: 280 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...280 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1615 Arg Val Met Ala Val Arg Ile Met Ala Thr Val Trp Thr Asn Ser Cys 1 5 10 Lys Glu Phe Gly Leu Val Ser Leu Phe Leu Ser Leu Leu Val Leu Val 25 Val Val Gly Arg Phe Phe Ile Lys Gly Ala Phe Tyr Gly Leu Lys Asn 40 Gly Val Leu Gly Met Asp Leu Ser Val Ser Phe Gly Ala Leu Ser Ala 55 Phe Val Tyr Ser Leu Tyr Ala Met Leu Val Ser Gin Glu Thr Tyr Phe 70 75 1165 Giu Ala Ser Ser Thr Ilie Leu Thr Leu Val Phe Giy Ser Lys Phe Leu 90 Giu Leu Lys Ala Arg Leu Phe Ala Asn Glu Lys Cys Leu Ala Leu Giu 100 105 110 Ser His Giu Ile His Ser Val Ile Val Val Giu Asn Gly Lys Gin Ile 115 120 125 Giu Lys His Pro Lys Asp Val Ala Ile Gly Ser Val Val Trp Val Pro 130 135 140 Ser Gly Ala Lys Ile Ala Leu Asp Gly Val Leu Leu Asn Ser Ala Ser 145 150 155 160 Val Asp Ala Ser Leu Ile Ser Gly Giu Phe Lys Pro Leu Giu Leu Gly 165 170 175 Val Asn Asp Pro Ile Leu Gly Gly Tyr Val Asn Val Gly Val Pro Phe 180 185 190 Ser Tyr Gin Val Ser Ala Thr Phe Gin Asn Ser Arg Leu Ser Ser Leu 195 200 205 Leu Giu Thr Leu Lys Lys Ser Phe Leu Giu Lys Pro Leu Ile Giu Ser 210 215 220 Ser Ala Asn Lys Ile Ala Asp Ile Phe Ser Lys Ala Val Leu Phe Leu 225 230 235 240 Ala Phe Val Ser Phe Leu Leu Trp Gin Phe Gly Leu Gly Gly Asn Phe 245 250 255 Giu Lys Ala Leu Met Val Cys Ile Ser Val Leu Val Ile Ser Cys Pro 260 265 270 Cys Ala Phe Ala Arg Leu Arg Pro 275 280 INFORMATION FOR SEQ ID NO:1616: SEQUENCE CHARACTERISTICS: LENGTH: 196 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni
FEATURE:
NAME/KEY misc_feature LOCATION .196 (xi) SEQUENCE DESCRIPTION: SEQ ID N0:1616 Arg Ala Ser His Lys Leu Pro Leu Arg Val Arg Ser Ala Thr Pro Ile 1 5 10 Ala Leu Val Ile Gly Val Phe Lys Asn Pro Leu Ile Val Phe Lys Giu -25 Ala Leu Phe Leu Giu Thr Leu Ala Lys Val Lys Lys Ile Phe Ile Asp 40 Lys Thr Gly Thr Leu Thr Gin Lys Glu Val Leu Leu Lys Glu Lys Ile 55 Ile His Giu Glu Phe Asp Glu Arg Leu Leu Lys Sen Leu Leu Lys Thr 70 75 Arg Giu His Leu Ala His Asn Ala Ile Leu Lys Thr Leu Asp Gly Asp 90 Glu Val Asp Leu Giu Lys Ile Glu Phe Phe Ala His Gly Leu Lys Ala 100 l05 110 Ser Tyr Gin Asn Glu Thr Leu Leu Val Gly Ser Leu Lys Phe Leu Asn 115 120 125 Ala Met Gly Val Asp Leu Lys Val Lys Giu Ser Ala Asn Ile Met Val 1166 130 Phe Leu Leu Cys 135 140 Ala Lys Asn Lys Thr Leu Cys Ala Leu Phe Ile Leu Giu Giu 150 155 160 Lys Ala Asn Ala Lys Giu Val Ile Gin Ala Leu Gin Asn Gin 165 170 175 Giu Leu Giu Ile Leu Ser Gly Asp Asn Giu Ser Ser Val Lys 180 185 190 Ala Lys 195 INFORMATION FOR SEQ ID NO:i6i7: SEQUENCE CHARACTERISTICS: LENGTH: 667 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .667 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i1617 9*
S
*5*S S. *S S
S.*
o 55 S S
S
Thr 1 Leu Ile Val Val Thr Asn Leu Val Asn 145 Asp Arg Val Val Asp 225 Thr Ala Pro Val1 Ser Asn Sen Sen Leu Leu
LYS
130 Leu Thn Ser Lys Arg 210 Lys Tyr Ser Thr Ser Sen 35 Leu Asn Ile Ser Gly 115 Asp Sen Giy His Lys 195 Leu Giu Lys Asn Lys Thr 20 Tyr Leu Giy Asp 100 Val Leu Gly Gly 180 Glu Ala Val Val Pro Ala Pro Lys
S
Phe Met Sen Giu Sen Gly Trp Ala Arg 55 Pro Lys Asp 70 Tnp Ala Tyr Leu Lys Val Asp Gly Val Giu Val Thr 135 Giu Gin Val 150 Giy Val-Ile 165 Tyr Ile Gin Gly Ala Ile Pro Lys Pro 215 Val Gly Gly 230 Leu Lys Ala 245 Asp Val Lys Ile Val Gin Ile Leu 40 Asp Ala Gin Leu Sen 120 Leu Ala Leu Sen Pro 200 Arg Ile Ile Ile Ala 25 Ile Ang Lys Tyr Gin 105 Giu Gin Asn Giu Leu 185 Leu Arg Val
LYS
10 Asn Tyr Vai Val1 Aia 90 Asp Val Asn Aia Asn 170 Asn Lys Gly Met Giu 250 Giu I.le Ile Leu Giu 75 Leu Phe Ala Asp Ile 155 Gly Asp Ile Ala Val 235 Lys Gin Asp Ile Glu Ile Sen Tyr Ser Ser 140 Lys Phe Leu Lys Ala 220 Ang Ile Val1 Thn Phe Gin Gly Ser Tyr Vai 125 Leu Asn Giu G iu Asp 205 Asn Tyr Ala Thr Tyr Vai Ang Lys Asp Leu Asn Ser Asp Asp Ser Arg Tyr 110 Gly Giy Ile Arg Ser Asn Lys Ile 175 Giu Ile 190 Ile Ala Leu Asn His Ala Thr Leu 255 Pro Gly Gly Ang Ser Lys Ala Phe Tyr Asn 160 Ile Val Ser Gly Asp 240 Gin Thr Ser Val Tyr Asp Arg Ser Glu 265 270 1167 Leu Ile Giu Lys Gly Ile Asp Asn Leu Ile His Thr Leu Ile Giu Giu Ser Ser 305 Phe Gly Met Asn Gly 385 Ile Ile Glu Ser 465 Vali Giu Thr Ser Lys 545 Ile Leu Lys Met As n 625 Leu Vali 290 Aia Leu Gly Vai Thr 370 Ala Phe Thr Vai Ser 450 Leu Leu Phe Ile Asn 530 Vai Giu Ser Gly Leu 610 Asp Lys 275 Ile Leu Leu Ile Giu 355 Gin Ile Aia Lys Pro 435 Giu Arg Giy Ile Asn 515 Ala Giy Thr Tyr Leu 595 Leu Thr Thr Vai Leu Val Val Met Arg 325 Aia Ile 340 Asn Aia Arg Val Phe Phe Leu Thr 405 Thr Phe 420 Vai Leu Ser Pro V~al Vai Leu Gly 485 Pro Gin 500 Gly Val Aia Ile Arg Ala Tyr Ile 565 Lys Giu 580 Thr Asn Thr Gly Asp Lys Leu Lys 645 Val Ile 310 Tyr Ala His Asn Ala 390 Gly Ala Met Val1 Leu 470 Gly Ile Giy Lys Asn 550 Glu Vali Ser Ile Leu 630 Glu Ile 295 Ile Phe Ile Lys Ala 375 Leu Gin Met Val1 Asn 455 Lys Leu Asn Ile Gin 535 Thr Leu Arg Trp Arg 615 Gin Ser Leu 280 le Thr Asn Arg His 360 Ile Met G iu Leu Trp 440 Ala Phe Val1 Glu Asp 520 Leu Ser Lys Asp Thr 600 Thr Giu Leu Asp Ala Leu Ile Ala 345 Leu Met Ile Giu Val1 425 Leu Phe Arg Val1 Gly 505 Thr Asp Thr Pro Lys 585 Pro Leu Ser Leu 665 Ile Pro Giu 330 Met Gin Gin Ile Lys 410 Gly Ile Phe Tyr Ala 490 Val Ala Phe Asp Gin 570 Leu Pro Leu Ala Giy 650 G iu t.
Asn Gly Tyr Tyr Ile Thr INFORMATION FOR SEQID NO:i618: SEQUENCE CHARACTERISTICS: LENGTH: 95 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori 1168 (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...95 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1618 Arg Asn Val Glu Ala Arg Tyr Tyr Tyr Gly Asp Thr Ser Tyr Phe Tyr 1 5 10 Leu His Ala Gly Val Leu Gin Glu Phe Ala His Phe Gly Ser Asn Asp 25 Val Ala Ser Leu Asn Thr Phe Lys Ile Asn Ala Ala Arg Ser Pro Leu 40 Ser Thr Tyr Ala Arg Ala Met Met Gly Gly Glu Leu Gin Leu Ala Lys 55 Glu Val Phe Leu Asn Leu Gly Val Val Tyr Leu His Asn Leu Ile Ser 70 75 Asn Ala Ser His Phe Ala Ser Asn Leu Gly Met Arg Tyr Ser Phe 90 INFORMATION FOR SEQ ID NO:1619: SEQUENCE CHARACTERISTICS: LENGTH: 211 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature S* LOCATION 1...211 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1619 Lys Pro Thr Asn Val Trp Ala Asn Ala Ile Gly Gly Ala Ser Leu Asn 1 5 10 Ser Gly Ser Asn Ala Ser Leu Tyr Gly Thr Ser Ala Gly Val Asp Ala 25 Phe Leu Asn Gly Asn Val Glu Ala Ile Val Gly Gly Phe Gly Ser Tyr 35 40 Gly Tyr Ser Ser Phe Ser Asn Gin Ala Asn Ser Leu Asn Ser Gly Ala 55 Asn Asn Ala Asn Phe Gly Val Tyr Ser Arg Phe Phe Ala Asn His Pro 70 75 Glu Phe Asp Phe Glu Ala Gln Gly Ala Leu Gly Ser Asp Gin Ser Ser 90 Leu Asn Phe Lys Ser Thr Leu Leu Gin Asp Leu Asn Gin Ser Tyr Asn 100 105 110 Tyr Leu Ala Tyr Ser Ala Thr Ala Arg Ala Ser Tyr Gly Tyr Asp Phe 115 120 125 Ala Phe Phe Arg Asn Ala Leu Val Leu Lys Pro Ser Val Gly Val Ser 130 135 140 Tyr Asn His Leu Gly Ser Thr Asn Phe Lys Ser Asn Ser Gin Ser Gin 145 150 155 160 Val Ala Leu Lys Asn Gly Ala Ser Ser Gin His Leu Phe Asn Ala Asn 165 170 175 Ala Thr Trp Lys Arg Val Ile Ile Met Gly Thr Leu His Thr Phe Ile 180 185 190 1169 Cys Met Arg Glu Phe Tyr Lys Ser Ser Leu Thr Leu Asp Arg Met Met 195 200 205 Trp Arg Leu 210 INFORMATION FOR SEQ ID NO:1620: SEQUENCE CHARACTERISTICS: LENGTH: 78 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...78 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1620 Asn Lys Ile Leu Ala Ser Glu Leu Glu Phe Lys Phe Leu Ile Lys Gly 1 5 10 Val Ile Met Ala His His Glu Glu Gln His Gly Gly His His His His 25 His His His Thr His His His His Tyr His Gly Gly Glu His His His 40 His His His Ser Ser His His Glu Glu Gly Cys Cys Ser Thr Ser Asp 55 SSer His His Gin Glu Glu Gly Cys Cys His Gly His His Glu 70 INFORMATION FOR SEQ ID NO:1621: SEQUENCE CHARACTERISTICS: LENGTH: 345 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...345 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1621 Gly Val Leu Ile Arg Thr Pro Lys His Leu Thr Lys Gin Glu Ser Val 1 5 10 Asn Leu Gly Ala Tyr Tyr Thr Pro Pro Tyr Leu Val Asp Cys Ala Tyr 25 Lys Leu Leu Lys Lys His Val Gly Ile Glu Asn Tyr Thr Leu Leu Asp 40 Thr Ala Cys Gly Asn. Lys Glu Phe Leu Lys Leu His His Pro Lys Lys 1170 55 Ile Gly Ala Asp Ile Asp Pro Lys Cys Asp Ala Leu Ile Ile Asn Ala 70 75 Leu Ala Asn Pro Lys Arg Glu Asn Tyr Gly Ile Ser Gin Asp Glu Pro 90 Leu Ile Ile Val Gly Asn Pro Pro Tyr Asn Asp Arg Thr Ser Phe Ile 100 105 110 Lys Gin Asp Ile Lys Asn Lys Asp Phe Ile Phe Glu Ile Asp Asn Asp 115 120 125 Leu Lys Ser Arg Asp Leu Gly Ile Ser Phe Leu Lys Ser Phe Ala Ile 130 135 140 Leu Lys Pro Ala Phe Ile Cys Val Leu His Pro Leu Ser Tyr Leu Ile 145 150 155 160 Lys Glu Ala Asn Phe Lys Gin Leu Lys Leu Phe Lys Asp His Tyr Arg 165 170 175 Leu Leu Asp Ala Phe Val Val Ser Ser Lys Ser Phe Thr Lys Ser Asn 180 185 190 Glu Phe Pro Ile Val Ile Ala Leu Tyr Glu Arg Gly Arg Met Asp Tyr 195 200 205 Ala Gly Ile Arg Arg Phe Val Phe Pro Thr Asp Cys Asp Thr Thr Leu 210 215 220 Cys Leu Asn Asp Phe Asp Tyr Ile Ala Asn Tyr Val Asp Lys Tyr Pro 225 230 235 240 Asn Ala Lys Lys Val Gly Ala Cys Val Gly Tyr Phe Phe Pro Met Arg 245 250 255 Asp Ile Asn Ala Leu Lys Arg Asn Lys Thr Phe Leu Asn Ala Pro Ser 260 265 270 Glu Asn Ala Val Arg Ile Ser Gin Asp Lys Leu Ile Tyr Tyr Gin Tyr 275 280 285 Ile His Tyr Phe Lys Glu Ile Ala Pro Lys Ile Pro Tyr Tyr Phe Gly 290 295 300 Asn Leu Asp Ile Ile Ile Asp His Phe Ala Phe Leu Glu Ile Lys Asp 305 310 315 320 Ala Phe Leu Lys Asp Lys Arg Ala Arg Leu Glu Tyr Phe Lys Lys Leu 325 330 335 I Phe Gln Gly His Pro Cys Glu Phe Asp 340 345 INFORMATION FOR SEQ ID NO:1622: SEQUENCE CHARACTERISTICS: S* LENGTH: 262 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM- Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...262 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1622 Asn Ile Leu Lys Asn Cys Phe Lys Asp Thr Leu Val Ser Leu Ile Lys 1 5 10 Val Ser Gly Asp Lys Lys Val Ile Glu Val Ser Ile Pro Leu Thr Ser 25 Ile Ser Gly Lys Ala Arg Val Lys Ile Arg His Ala Phe Ser Asp Tyr 40 1171 Gly Ile Ser Thr Ala Thr Arg Lys Ilie Pro Phe Ser Leu Lys His Tyr 55 Val Phe Asn Ala Lys Thr 145 Leu Giu Gin Thr Ile 225 Phe Glu Giu Glu Asn Lys Phe 130 Arg Leu Leu Ala Pro 210 Ile Gly
LYS
Trp Leu Lys Arg 115 Leu Glu Arg Ser Met 195 Leu His Leu Ile Gin Thr Val 100 Leu Giu Arg Ile Giu 180 Leu Leu Giu Leu Leu 260 Ile Thr Lys Gly Lys Phe Ser 165 Ile Asn Thr Ser 245 Gin Giy 70 Leu Thr Leu Gin Arg 150 Tyr Val1 Phe Arg Asn 230 Gin Asn Tyr Lys Leu Ile Lys 135 Ser Pro Ile Cys Thr 215 Ala Val Asp Asp Tyr Ser 120 Gin His Leu Lys Phe 200 Ala Leu His Val1 Giu Giu 105 Leu Phe Gin Leu Giu 185 Ser Met Val His Pro Lys Leu Giu Ile Phe Ile 170 Gin Ile Pro Phe Asn 250 Ile Tyr Ser Asn Giu Gly 155 His Gin Leu Lys Leu 235 Asp Lys His Giu Leu Asp 140 G iy Ser Tyr Giu Giu 220 Giu Va 1 Asp Phe Met Giu 125 As n Met Phe Gly Leu 205 His Met Leu Lys Leu Ile 110 Asn Phe Asp Asp Ser 190 Lys Aia Leu Lys (2) e..
C
INFORMATION FOR SEQ ID NO:1623: SEQUENCE CHARACTERISTICS: LENGTH: 413 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAM~E/KEY: misc-feature LOCATION .413 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1623 1Lys Ala Leu Asn Asp Cys Met Val Phe Phe His 10 i Asn Phe Ile Tyr Ser Leu Met Val Ala Phe Leu 25 Gly Val Leu Leu Lys Ala Asp Gly Met Ala Lys 40 i Val Gly Giu Arg Leu Val Trp Asp Lys Leu Thr 55 *i Giu Lys Asn His Ile Pro Gin Lys Leu Tyr Tyr 70 75 *i Asp Lys Giu Leu Ser Ala Giu Ile Gin Ser Asn 90 Leu Arg Asp Ala Asn Asn Thr Leu Ile Gin Ala 100 105 r Gin Asp Leu Gin Ile His Ile Tyr Lys Lys Gly Let Let Lei Lei G1l Th: Se: Lys Phe Lys Leu Asn Val1 Leu Glu Lys His Gin Leu Leu Thr Ile 110 Asp Ile is Leu Thr Gly Ser Tyr Pro Tyr Ile Ser Leu Phe Ser Tyr Ile Phe 1172 115 120 125 Leu Asp Phe Ile Pro Ile Val Phe Thr Arg Lys Giu Arg Thr Leu Leu 130 135 140 Leu Ser Leu Gin Thr Ser Pro Tyr Gin Asp Ile Val Lys Ala Thr Asn 145 150 155 160o Asp Pro Leu Leu Ala Asn Gin Leu Met Asn Ala Tyr Lys Lys Ser Val 165 170 175 Pro Phe Lys Arg Leu Val Lys Asn Asp Lys Ile Ala Ile Val Tyr Thr 180 185 190 Arg Asp Tyr Arg Val Gly Gin Ala Phe Gly Gin Pro Thr Ile Lys Met 195 200 205 Ala Met Val Ser Ser Arg Leu His Gin Tyr Tyr Leu Phe Ser His Ser 210 215 220 Asn Gly Arg Tyr Tyr Asp Ser Lys Ala Gin Giu Val Ala Gly Phe Leu 225 230 235 240 Leu Glu Thr Pro Val Lys Tyr Thr Arg Ile Ser Ser Pro Phe Ser Tyr 245 250 255 Gly Arg Phe His Pro Val Leu Lys Vai Lys Arg Pro His Tyr Gly Val 260 265 270 Asp Tyr Ala Ala Lys His Gly Ser Leu Ile His Ser Ala Ser Asp Gly 275 280 285 Arg Val Giy Phe Ile Gly Val Lys Ala Gly Tyr Gly Lys Val Val Giu 290 295 300 Ile His Leu Asn Giu Leu Arg Leu Val Tyr Ala His Met Ser Ala Phe 305 310 315 320 Ala Asn Gly Leu Lys Lys Gly Ser Phe Val Lys Lys Gly Gin Ile le 325 330 335 Gly Axg Val Gly Ser Thr Gly Leu Ser Thr Gly Pro His Leu His Phe 340 345 350 Gly Val Tyr Lys Asn Ser Arg Pro Ile Asn Pro Leu Giy Tyr Ile Arg 355 360 365 :Thr Ala Lys Ser Lys Leu His Gly Lys Gin Arg Giu Val Phe Leu Giu 370 375 380 Lys Ala Gin Tyr Ser Lys Gin Lys Leu Giu Giu Leu Phe Lys Thr His :9385 390 395 400 *Ser Phe Glu Lys Asn Ser Phe Tyr Leu Leu Glu Gly Phe *405 410 INFORMATION FOR SEQ ID NO:1624: Li) SEQUENCE CHARACTERISTICS: LENGTH: 253 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES ORIGINAL SOURCE: ORGANISM: -Helicobacter pylori (ix) FEATURE: NAE/KEY: misc-feature LOCATION .253 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1624 Gly Cys Leu Met Lys Ser Ile Leu Leu Phe Met Ile Phe Val Val Cys 1 5 10 Gin Leu Glu dly Lys Lys Phe Ser Gin Asp Asn Phe Lys Val Asp Tyr 25 Asn Tyr Tyr Leu Ang Lys Gin Asp Leu His Ile Ile Lys Thr Gin Asn *40 1173 Asp Leu Ser Asn Ala Trp Tyr Leu Pro Pro Gin Lys Ala Pro Lys Giu 55 His Ser Trp Val Asp Phe Ala Lys Lys Tyr Leu Asn Met Met Asp TIyr 70 75 Leu Gly Thr Tyr Phe Leu Pro Phe Tyr His Ser Phe Thr Pro Ile Phe 90 Gln Trp, Tyr His Pro Asn Ile Asn Pro Tyr Gin Arg Asn Glu Phe Lys 100 105 110 Phe Gin Ile Ser Phe Axg Val Pro Val Phe Arg His Ile Leu Trp Thr 115 120 125 Lys Gly Thr Leu Tyr Leu Ala Tyr Thr Gin Thr Asn Trp Phe Gin Ile 130 135 140 Tyr Asn Asp Pro Gin Ser Ala Pro Met Arg Met Ile Asn Phe Met Pro 145 150 155 160 Giu Leu Ile Tyr Val Tyr Pro Ile Asn Phe Lys Pro Phe Gly Giy Lys 165 170 175 Ile Giy Asn Phe Ser Giu Ile Trp Ile Giy Trp Gin His Ile Ser Asn 180 185 190 Gly Val Gly Gly Ala Gin Cys Tyr Gin Pro Phe Asn Lys Giu Gly Asn 195 200 205 Pro Giu Asn Gin Phe Pro Gly Gin Pro Val Ile Val Lys Asp Tyr Asn 210 215 220 Gly Gin Lys Asp Vai Arg Trp Giy Gly Cys Arg Ser Vai Ser Ala Gly 225 230 235 240 Asn Ala Leu Cys Phe Val Trp Cys Gly Lys Arg Giu Ala 245 250 INFORMATION FOR SEQ ID NO:i625: SEQUENCE CHARACTERISTICS: LENGTH: 83 amino acids TYPE: amino acid TOPOLOGY: linear MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylonl (ix) FEATURE: NAME/KEY: misc-feature LOCATION .83 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i625 Met Asn Arg Ala Trp Ile Lys Lys Lys Met Lys Lys Ile Lys Leu Thr 1 5 10 *Lys Arg Met Ile Ala Thr Ala Lys Lys Ala Leu Ser Lys Sen Tyr Gly 25 Tyr Cys Leu Val Gly Arg The Leu Ile Phe Phe Leu Arg Phe Cys Ile 40 Phe Phe Trp His Ala Gly Lys Lys Ser Tyr Cys Pro Sen Leu Ala Val 55 Lys Lys Thr Ang Lys Pro Gly Cys Ang Gly Ile Giu Ser Phe Tyr Gin 70 75 Pro Ser Lys INFORMATION FOR SEQ ID NO:i626: SEQUENCE CHARACTERISTICS: 1174 LENGTH: 93 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KE: misc_feature LOCATION .93 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1626 Arg Ile Glu Trp Gly Asn Arg His Cys Gly Ala Leu 1 5 10 Ser Val Ser Met Leu Leu Leu Phe dly Ala Phe Leu 25 Gly Ile Leu Asn Leu Leu Pro Ile Pro Ala Leu Asp 40 Leu Gly Val Val Phe Lys Asn Ile Phe His Ile Ala 55 Ile Gin Asn Ala Leu Trp Leu Val Gly Val Gly Phe 70 75 Met Phe Leu Gly Leu Phe Asn Asp Ile Thr Arg Leu Ser His Ala Asn Ser Ile Asn Leu Gly Ala Gin Met Leu Pro Thr Pro Leu Val Phe Vai Leu
C
*9e.
C. C.
C C
C
CC
C
CC
C C
C
INFORMATION FOR SEQ ID NO:l627: SEQUENCE CHARACTERISTICS: LENGTH: 424 amino acids TYPE: amino acid TOPOLOGY: linear (ii) 14OLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacten pyloni (ix) FEATURE: N'AE/KEY: misc-feature LOCATION .424 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1627 Asn Leu Gly Gly Ala Aia-Asn Val Ala Asn Asn Leu 1 5 10 Ala Lys Val Phe Leu Cys Gly Val Val Gly Asp Asp 25 His Phe Ile Ser Thr Leu Asn Sen Ile Arg Ile Asp 40 Leu Ile Asp Lys Thr Arg Cys Thn Thr Leu Lys Thr so 55 60 Gln Asn Gin Gin Ile Val Arg Val Asp Lys Glu Ile 70 75 Asn Ala Asp Leu Arg Lys Asn Leu Leu Asp Phe Ilie 90 Gin Giu Ile Asp Gly Val Ilie Leu Ser Asp Tyr Asn 100 105 Thr Leu Thr Arg Lys Ala Lys Sen Lys Sen Ile Asp Glu G ly 110 Lys Lys Val Ala Leu Ile Leu 1175 Asp Phe Giu Leu Thr Gin Thr Ile Ile Thr Leu Ala Asn Lys His His 115 120a Lys Leu 130 His Ala 145 His Leo Leo Gin Gin Giy Ile Ala 210 Ala Ser 225 Cys Glu Ser Ala His Pro Asn Gin 290 Lys Gly 305 Leo Val As p Lys Ser Leu Ile Lys 370 Asp Tyr 385 Arg Leu Lys Ile Ile Ser Lys Glu Ile 195 Lys Leo Phe Leu Lys 275 Gin His Val Arg Ser 355 Leo Leo Ile Lys Leu Leo Leu Thr 180 Ala Glu Thr Ala Ala 260 Ile Lys Ala Gly Pro 340 Cys Ile Asn Glu Arg 420 Cys Ile Asp Tyr Phe Val1 Leo Asn 245 Ser Leo Ile Ser Leu 325 Ile Val Gin Lys Phe 405 Thr Asp Thr 150 Ser His Leo Ser 230 Ala Leo Pro Val1 Tyr 310 Asn Val Asp Ala G lu 390 Glu His Pro 135 Pro His Ile Glu Asp 215 Leu Ala Giu Leu Phe 295 Leu Ser Ser Tyr Leu 375 Val Giu Asn Lys Gly Lys Asn Arg Ala Ala Asn Leo 170 Ala Met Pro 185 Lys Gly Glu 200 Vai Thr Gly Leu Glu Ser Ala Ala Val 250 Gl Ile Ala 265 Glu Lys Leu 280 Thr Asn Giy Gin Lys Ala Asp Asn Ser 330 Glu Lys Asp 345 Val Val Val 360 Lys Pro Asp Ile Gly Ser Gly Tyr Ser 410 Asp Asp Glu 155 Ser Leu Leu Ala Lys 235 Val1 Leu Leu Cys Lys 315 Ile Arg Phe Ile Gbu 395 Tyr 140 Leu Lys Val Val G ly 220 Ser Val Ile Gbu Phe 300 Ala Lys Ala Gly Leu 380 Leu Ser Lys Giu Gin Ala Leo Thr Leu 190 Asn Cys 205 Asp Thr Leo Lys Gly Lys Leu Asn 270 Thr Leo 285 Asp Ile Leo Giy Arg Leo Phe Leu 350 Gbu Asp 365 Val Lys Ala Lys Tyr Ala Gin 175 Ser Pro Val1 Glu Met 255 Gin Glu Leu Asp Lys 335 Leo Thr Gly Giu S er Leo 160 Ile Glu Thr Ile Ala 240 Gly Thr Arg His Ile 320 Gly Ala Pro Ala Thr 400 a. a Thr Ser Ala Ile Ile Glu 415 .00.
too INFORMATION FOR SEQ ID NO:1628: SEQUENCE CHARACTERISTICS: LENGTH: 321 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .321 (xi) SEQUENCE DESCRIPTION: SEQ, ID NO:1628 Gly Ser Leo Met Val Asn Val Phe Phe Lys Gin Gin Lys Phe Val Ile 10 Lys Lys Arg Phe AsnAsp Phe Asn Giy Phe Asp Ile Glb Glu Asri Glu 1176 25 Val Leu Trp Phe Giu Leu Ile Asn Pro Thr Pro Asn Glu Leu Ala Thr 40 Leu Ser Gin Giu Tyr Ala Ile His Tyr Asn Thr Asp His Ser Gin Arg 55 Val Ser Ser Val Thr Lys Tyr Trp Glu Asp Ser Ser Ser Val Thr Ile 70 75 Asn Ala Phe Phe Thr Asn Gin Asp Giu Asn Giu Thr Phe His Met Giu 90 Met Ala Thr Phe Ile Leu Ser Asn Asn Ile Leu Phe Thr Ile Tyr Tyr 100 105 110 Giy Thr Leu Giu Ile Phe Asp Ser Ile Gin Lys Lys Val Leu Ala Ser 115 120 125 Pro Lys Lys Phe Giu Asp Gly Phe Asp Ile Leu Thr Lys Ile Phe Giu 130 135 140 Val Tyr Phe Giu Lys Gly Val Giu Cys Leu Giu Trp Ile Asn Lys Gin 145 150 155 160 Thr Ser Leu Leu Arg Lys Asn Ile Ile Phe Lys Giu Thr Ser Thr His 165 170 175 Asp Asp Ile Leu Vai Arg Leu Ser Asn Leu Gin Giu Phe Asn Val Ala 180 185 190 Leu Arg Asp Ser Phe Phe Asp Lys Arg Arg Ile Ile Thr Ala Leu Leu 195 200 205 Arg Ser Asn Lys Val Asp Ser Asp Thr Lys Asn Asn Leu Asn Ile Ile 210 215 220 Leu Thr Asp Phe Ser Ser Leu Vai Giu Ser Thr Thr Val Asn Leu Asn 225 230 235 240 Ser Leu Asp Asn Ile Gin Asn Leu Phe Aia Ser Gin Val Asn Val Giu 245 250 255 Gin Asn Lys Ile Ile Lys Leu Phe Thr Vai Ala Thr Met Ala Met Met ***260 265 270 :*.Pro Pro Thr Leu Ile Gly Thr Ile Tyr Gly Met Asn Phe Lys Phe Met *Pro Giu Leu Giu Trp Gin Tyr Gly Tyr Leu Phe Ala Leu Ile Val Met 290 295 300 *'Ala Ile Ser Thr Ile Leu Pro Val Ile Tyr Phe Lys Lys Lys Gly Trp, .305 310 315 320 Leu INFORMATION FOR SEQ ID NO:i629: SEQUENCE CHARACTERISTICS: LENGTH: 244 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .244 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1629 Pro Phe Met Giu Phe Leu Ser Ser Leu Leu Asp Ala Leu Ser Thr Pro 1 5 10 His Giy Ile Val Ser Leu Ala Thr Leu Thr Leu Leu Giu Ile Val Leu 25 1177 Gly Ile Asp Asn Ile Ile Phe Ile Thr Val Met Val Tyr Lys L 40 Lys His Gin Gin Asn Lys Val Met Ile Leu Gly Leu Gly Leu Ala Met 55 Ile Thr Arg Ile Gly Leu Leu Gly Ser Leu Phe Phe Ile Ser His Leu 70 75 Gin Lys Pro Leu Phe Ala Ile Ala Gly Met Ser Phe Ser Trp Arg Asp 90 Val Val Leu Leu Leu Gly Gly Ala Phe Leu Ala Phe Lys Ala Leu Val 100 105 110 Glu Leu Lys Glu Gin Ile Tyr Pro Lys Glu Lys Arg Gin Glu Lys Ala 115 120 125 Phe Gly Phe Phe Ile Thr Leu Ile Glu Ile Met Phe Leu Asp Ile Val 130 135 140 Phe Ser Leu Asp Ser Val Ile Thr Ala Ile Gly Ile Ala Lys His Leu 145 150 155 160 Glu Val Met Ala Leu Ala Ile Ile Leu Ser Val Ile Val Met Met Phe 165 170 175 Phe Ser Lys Ile Val Gly Asp Phe Ile Glu Lys His Tyr Arg Val Lys 180 185 190 Thr Leu Ala Phe Val Phe Leu Leu Val Val Gly Val Phe Leu Phe Leu 195 200 205 Glu Gly Leu His Leu His Ile Asn Lys Asn Tyr Leu Tyr Ala Gly Ile 210 215 220 Gly Phe Ala Leu Leu Ile Glu Cys Leu Asn Ile Phe Ile Glu Lys Lys 225 230 235 240 Met Lys Lys Ser INFORMATION FOR SEQ ID NO:1630: SEQUENCE CHARACTERISTICS: LENGTH: 156 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: S(A) ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...156 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1630 Val Tyr Gly Phe Trp Ala Cys Val Leu Cys Gly Phe Lys Phe Gly Phe S1 5 10 Val Tyr Phe Ala Gin Thr Arg Ala Phe Gin Phe Arg Gin Asn His Ser 25 Phe His Arg Tyr Gin Asn Glu His Asp Phe Arg Pro Val His Ala His 40 Ser Arg Glu Phe Leu Arg Trp Gly Val Gly Glu Ile Leu Gly Ala Leu 55 Leu Gly Val Gly Pro Arg Asn Leu Gly Val Asp Phe Tyr Leu Arg Leu 70 75 Cys Leu Asp Leu Ala Phe Ala Phe Phe Arg Leu Ser Lys Leu Ala Leu 90 Tyr Phe Ser Glu Gin Gin Arg Ala Arg Val Leu Phe Gly Phe Asn Asp 100 105 110 Leu Phe Trp Arg Glu Leu Leu Pro Phe Trp Leu Ala Gin Leu Cys Arg 1178 115 120 125 Arg Ser Phe Ala Asp Pro Tyr Phe Phe Ile Leu Phe Gly Ser Asp Thr 130 135 140 Phe Arg Ser Arg Ile Leu Ala Tyr Phe Lys Arg His 145 150 155 INFORMATION FOR SEQ ID NO:1631: SEQUENCE CHARACTERISTICS: LENGTH: 162 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...162 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1631 Arg Tyr Ser Asp Gin Thr Asn Leu Leu Ala Leu Asn Ala Ala Ile Glu 1 5 10 Ala Ala Arg Ala Gly Glu His Gly Arg Gly Phe Ala Val Val Ala Asp 25 Glu Val Arg Asn Leu Ala Gly Arg Thr Gin Lys Ser Leu Ala Glu Ile 40 Asn Ser Thr Ile Met Val Ile Val Gin Glu Ile Asn Asp Val Ser Ser 55 Gin Met Asn Leu Asn Ser Gln Lys Met Glu Arg Leu Ser Asp Met Ser 70 75 Lys Ser Val Gin Glu Thr Tyr Glu Lys Met Ser Ser Asn Leu Ser Ser 90 Val Val Leu Asp Ser Asn Gln Ser Met Asp Asp Tyr Ala Lys Ser Gly 100 105 110 His Gin Ile Glu Ala Met Val Ser Asp Phe Ala Glu Val Glu Lys Val 115 120 125 Ala Ser Lys Thr Leu Ala Asp Ser Ser Asp Ile Leu Asn Ile Ala Thr 130 135 140 His Val Ser Gly Thr Thr Met Asn Leu Asp Lys Gin Val Asn Leu Phe 145 150 155 160 eo* Lys Thr 0 INFORMATION FOR SEQ-ID NO:1632: SEQUENCE CHARACTERISTICS: LENGTH: 61 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori 1179 (ix) FEATURE: NAME/KEY: misc-feature LOCATION .61 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i632 Ile Cys Leu Lys Leu Asn Gin Gly Gly Vai Tyr Gin Lys Arg Val Gly 1 5 10 is Leu Leu Lys Val Ser Val Ile Thr Ala Cys Phe Asn Ser Giu Lys Thr 25 Ile Glu Asp Thr Ile Leu Ser Val Leu Asn Gin Thr Tyr Lys Asn Ile 40 Giu Tyr Ile Ile Ile Asp Giy Ala Ser Ala Ile Ala Leu 55 INFORMATION FOR SEQ ID NO:i633: SEQUENCE CHARACTERISTICS: (A LENGTH: 664 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .664 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i633 g Asn His Ile Val Arg Gly Val Asp Cys Asp Arg Gly Val Ser Ile Leu *1 5 10 Gly Val. Sen Leu Asn Sen Ang Vai Lys Giu le Leu Lys Giu Sen Ala Le isSr20 25 LeuHisSerMet Gin Asp Ser Leu His Phe Lys Val Lys Glu Val Gin 40 SerVa Leu Glu Asn Thr Tyr Thr Sen Met Gly Ile Val Lys Giu Met so 55 Leu Pro Giu Asp Thr Lys Arg Glu Ile Lys Ile Gin Leu Leu Lys Asn 70 75 Phe Ile Leu Ala Asn Sen His Vai Ala Gly Val Sen Met Phe Phe Lys 90 Asp Arg Glu Asp Leu Ang Leu Thr Leu Leu Ang Asp Asn Asp Thr Ile ~100 105 110 Lys Leu Met Glu Asn Pro Ser Leu Gly Ser Asn Pro Leu Val Gin Lys 11S 120 125 Ala Met Lys Asn Lys Glu fle Sen Lys Ser Leu Pro Tyr Tyr Ang Lys 130 135 140 Met Pro Asn Giy Ala Giu Val Tyr Gly Val Asp Ile Leu Leu Pro Leu 145 150 155 160 Phe Lys Giu Asn Thr Gin Glu Val Val Gly Val Leu Met Ile Phe Phe 165 170 175 Ser Ile Asp Ser Phe Ser Asn Giu Ile Thr Lys Asn Arg Ser Asp Leu 180 185 190 Phe Leu Ile Gly ValiLys Gly Lys Val Leu Leu Ser Ala Asn Lys Sen 195 200 205 Leu Gin Asp Lys Ser Ile Thn Glu Ile Tyr Lys Sen Vai Pro Lys Ala 210 215 220 Thn Asn Giu Val Met Ala Ile Leu Glu Asn Gly Ser Lys Ala Thr Leu 1180 225 230 235 240 Glu Tyr Leu Asp Pro Phe Ser His Lys Glu Asn Phe Leu Ala Val Glu 245 250 255 Thr Phe Lys Met Leu Gly Lys Thr Glu Ser Lys Asp Asn Leu Asn Trp 260 265 270 Met Ile Ala Leu Ile Ile Glu Lys Asp Lys Val Tyr Glu Gin Val Gly 275 280 285 Ser Val Arg Phe Val Val Val Ala Ala Ser Ala Ile Met Val Leu Ala 290 295 300 Leu Ile Ile Ala Ile Thr Leu Leu Met Arg Ala Ile Val Ser Asn Arg 305 310 315 320 Leu Giu Val Val Ser Ser Thr Leu Ser His Phe Phe Lys Leu Leu Asn 325 330 335 Asn Gin Ala His Ser Ser Asp Ile Lys Leu Val Glu Ala Arg Ser Asn 340 345 350 Asp Glu Leu Gly Arg Met Gin Thr Ala Ile Asn Lys Asn Ile Leu Gin 355 360 365 Thr Gin Lys Thr Met Gin Glu Asp Trp Gin Ala Val Gin Asp Thr Ile 370 375 380 Lys Val Val Ser Asp Val Lys Ala Gly Asn Phe Ala Val Arg Ile Thr 385 390 395 400 Ala Giu Pro Ala Ser Pro Asp Leu Lys Glu Leu Arg Asp Ala Leu Met 405 410 415 Asp His Ala Leu Phe Ala Arg Lys Arg Gly Thr His Met Pro Ser Ile 420 425 430 Phe Lys Ile Phe Glu Ser Tyr Ser Gly Leu Asp Phe Arg Gly Arg Ile 435 440 445 Gin Asn Ala Ser Gly Arg Val Glu Leu Val Thr Asn Ala Leu Gly Gin 450 455 460 Glu Ile Gin Lys Met Leu Glu Thr Ser Ser Asn Phe Ala Lys Asp Leu 465 470 475 480 S Ala Asn Asp Ser Ala Asn Leu Lys Glu Cys Val Gin Asn Leu Glu Lys 485 490 495 S Ala Ser Asn Ser Gin His Lys Ser Leu Met Glu Thr Ser Lys Thr Ile 500 505 510 Glu Asn Ile Thr Thr Ser Ile Gin Gly Val Ser Ser Gin Ser Glu Ala 515 520 525 Met Ile Glu Gin Gly Lys Asp Ile Lys Ser Ile Val Glu Ile Ile Arg 530 535 540 Asp Ile Ala Asp Gin Thr Asn Leu Leu Ala Leu Asn Ala Ala Ile Glu S545 550 555 560 Ala Ala Arg Ala Gly Glu His Gly Arg Gly Phe Ala Val Val Ala Asp 565 570 575 Glu Val Arg Lys Leu Ala Glu Arg Thr Gin Lys Ser Leu Ser Glu Ile 580 585 590 Glu Ala Asn Ile Asn Ile Leu Val Gin Ser Ile Ser Asp Thr Ser Glu 595 600 605 Ser Ile Lys Asn Gin Val Lys Glu Val Glu Glu Ile Asn Ala Ser Ile 610 615 620 Glu Ala Leu Arg Ser Val Thr Glu Gly Asn Leu Lys Ile Ala Ser Asp 625 630 635 640 Ser Leu Glu.Ile Ser Gin -Glu Ile Asp Lys Val Ser Asn Asp Ile Leu 645 650 655 Glu Asp Val Asn Lys Lys Gin Phe 660 INFORMATION FOR SEQ ID NO:1634: SEQUENCE CHARACTERISTICS: LENGTH: 425 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein 1181 (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .425 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1634 Arg Gly Giu Cys Tyr Phe Giu Arg Giu Ile Gly Leu Met Arg Lys Ile 1 5 10 is Phe Ser Tyr Ile Ser Lys Val Leu Leu Phe Ile Gly Val Val Tyr Ala 25 Giu Pro Asp Ser Lys Val Giu Ala Leu Giu Gly Arg Lys Gin Giu Ser 40 Ser Leu Asp Lys Lys Ile Arg Gin Giu Leu Lys Sen Lys Giu Leu Lys 55 Asn Lys Giu Leu Lys Asn Lys Asp Leu Lys Asn Lys Giu Giu Lys Lys 70 75 Giu Thr Lys Ala Lys Ang Lys Pro Arg Ala Giu Val His His Gly Asp 90 Ala Lys Asn Pro Thn Pro Lys Ile Thr Pro Pro Lys Ile Lys Gly Sen 100 105 110 Ser Lys Giy Val Gin Asn Gin Gly Val Gin Asn Asn Ala Pro Lys Pro 115 120 '125 Giu Giu Lys Asp Thr Thr Pro Gin Ala Thr Giu Lys Asn Lys Giu Thn 135 140 Ser Pro Ser Ser Gin Phe Asn Ser Ile Phe Gly Asn Pro Asn Asn Ala 145 150 155 160 Thr Asn Asn Thr Leu Giu Asp Lys Val Val Gly Gly Ile Sen Leu Leu *165 170 175 Val Asn Giy Ser Pro Ile Thr Leu Tyr Gin Ile Gin Giu Giu Gin Giu 180 185 190 Lys Ser Lys Val Sen Lys Ala Gin Ala Ang Asp Ang Leu Ile Ala Giu 195 200 205 Arg Ile Lys Asn Gin Giu Ile Giu Arg Leu Lys .Iie His Val Asp Asp 210 215 220 *Asp Lys Leu Asn Gin Giu Met Ala Met Met Ala Gin Gin Gin Giy Met 225 230 235 240 Asp Leu Asp His Phe Lys Gin Met Leu Met Ala Giu Gly His Tyr Lys 245 250 255 Leu Tyr Arg Asp Gin Leu Lys Giu His Leu Giu Met Gin Giu Leu Leu 260 265 270 Arg Asn Ile Leu Leu Thr Asn Val Asp Thr Ser Sen Giu Thr Lys Met 275 280 285 Arg Giu Tyr Tyr Asn Lys His Lys Giu Gin Phe Ser Ile Pro Thr Giu 290 295 300 Sle Giu Thr Val Arg Tyr Thr Ser Thr Asn Gin Giu Asp Leu Giu Arg 305 310 -315 320 Ala Met Aia Asp Pro Asn Leu Giu Val Pro Gly Val Ser Lys Ala Asn 325 330 335 Giu Lys Ile Giu Met Lys Thr Leu Asn Pro Gin Ile Ala Gin Val Phe 340 345 350 Ile Sen His Giu Gin Gly Ser Phe Thr Pro Val Met Asn Gly Gly Gly 355 360 365 Giy Gin Phe Ile Thr Phe Tyr Ile Lys Giu Lys Arg Giy Lys Asn Giu 370 375 380 Val Sen Phe Ser Gin Ala Lys Gin Phe Ile Ala Gin Lys Leu Val Giu 385 390 395 400 Giu Ser Lys Asp Lys Ile Leu Giu Giu His Phe Giu Lys Leu Arg Vai 405 410 415 Lys Sen Ang Ile Val Met Ile Arg Giu 1182 420 425 INFORMATION FOR SEQ ID NO:1635: Wi SEQUENCE CHARACTERISTICS: LENGTH: 336 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .336 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1635 Ile Val Gin His Phe Asn Phe Leu Tyr Lys Asp Sen Leu Phe Ser Ile 1 5 10 Ala Leu Phe Thr Phe Ile Ile Ala Leu Val Ile Leu Leu Giu Gin Ala 25 Arg Ala Tyr Phe Thr Arg Lys Arg Asn Lys Lys Phe Leu Gin Lys Phe 40 Ala Gin Asn Gin Asn Ala Tyr Ala Ser Ser Giu Asn Leu Asp Giu Leu 55 *Leu Lys His Ala Lys Ile Sen Ser Leu Met Phe Leu Ala Arg Ala Ty'r 70 75 *Ser Lys Ala Asp Val Giu Met Ser Ile Glu Ile Leu Lys Gly Leu Leu 90 Asn Arg Pro Leu Lys Asp Giu Giu Lys Ile Ala Vai Leu Asp Leu Leu 100 105 110 *Ala Lys Asn Tyr Phe Sen Val Gly Tyr Leu Gin Lys Thr Lys Asp Thr 115 120 125 Val Lys Giu Ile Leu Arg Phe Sen Pro Arg Asn Val Giu Ala Leu Leu **.130 135 140 Lys Leu Leu His Ala Tyr Giu Leu Glu Lys Asp Tyr Ser Lys Ala Leu 145 150 155 160 Glu Thr Leu Glu Cys Leu Giu Giu Leu Giu Val Pro Lys Ile Giu Thr 165 170 175 Ile Lys Asn Tyr Leu Tyr Leu Met His Leu Ile Giu Asn Lys Giu Asp 180 185 190 Ala Ala Lys Ile Leu His Val Ser Lys Ala Ser Leu Asp Leu Lys Lys 195 200 205 Ile Ala Leu Asn His Leu Lys Sen His Asp Giu Asn Leu Phe Trp Gin .210 215 220 Glu Ile Asp Thr Thr Giu-Arg Leu Giu Asn Val Ile Asp Leu Leu Trp 225 230 235 240 Asp Met Asn Ile Pro Ala Phe Ile Leu Giu Lys His Ala Leu Leu Gin 245 250 255 Asp Ile Ala Arg Ser Gin Gly Leu Leu Leu Asp His Lys Pro Cys Gin 260 265 270 le Phe Glu Leu Giu Val Leu Ang Aia Leu Leu His Sen Pro Ile Lys 275 280 285 Ala Ser Leu Thr Phe Giu Tyr Arg Cys Lys His Cys Lys Gin Ile Phe 290 295 300 Pro Phe Giu Sen His Arg Cys Pro Val Cys Tyr Gin Leu Ala Phe Met 305 310 315 320 Asp Met Val Leu Lys Ile Sen Lys Lys Thr His Ala Met Gly Val Asp 325 330 335 1183 INFORMATION FOR SEQ ID NO:1636: SEQUENCE CHARACTERISTICS: LENGTH: 255 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .255 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i636 a Ile Met Pro Arg Asn 65 Ile Leu Leu Glu Phe 145 Val Asp Thr
LYS
Asp 225 Gin Ang Lys Tyr Leu Asn Gly Ser Ala Giu 130 Glu Arg Leu Gin Gly 210
LYS
Gin Asn Lys Leu Thr Leu Glu Giu Arg Giu Leu Lys Leu 100 Lys Ala 115 le Sen Ala Leu Lys Ile Giu His 180 Ala Gin 195 Pro Asp Met Tyr Cys Ala Ang Leu Gin Leu Leu Arg Ile Lys Met Ile 165 Leu Phe His Ala Tyr 245 Ser Gin Giu Lys Ala Leu Glu Phe 70 Tyr His Ala Ser Ala Leu Gly Arg 135 Ala Gly 150 Gin Asn Phe Met Cys Val His Lys 215 Thr Ala 230 Gin Ala Thn Phe Lys Leu Asp Gly Val 125 Leu Gly Tyr Leu Leu 205 Leu Lys Glu Gly Ala Lys Thr Gly Gin Asn Asp His Leu Lys Gly Met Asn Lys Leu Val1 Lys Lys Ser Ala Lys 160 Leu Leu Glu Gin Glu 240 INFORMATION FOR SEQ ID NO:i637: SEQUENCE CHARACTERISTICS: LENGTH: 143 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein 1184 (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...143 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1637 Ala His Gin Ser Ser Arg Gly Val Ser Met Ile Leu Ala Cys Asp Val 1 5 10 Gly Leu Lys Arg Ile Gly Ile Ala Ala Leu Leu Asn Gly Val Ile Leu 25 Pro Leu Glu Ala Ile Leu Arg His Asn Arg Asn Gin Ala Ser Arg Asp 40 Leu Ser Asp Leu Leu Arg Lys Lys Asp Ile Gin Val Leu Val Val Gly 55 Lys Pro Asn Glu Ser Tyr Ala Asp Thr His Ala Arg Ile Glu His Phe 70 75 Ile Lys Leu Val Asp Phe Lys Gly Glu Ile Val Phe Ile Asn Glu Asp 90 Asn Ser Ser Val Glu Ala Tyr Glu Asn Leu Glu His Leu Gly Lys Lys 100 105 110 Asn Lys Arg Ile Ala Thr Lys Asp Gly Arg Leu Asp Ser Leu Ser Ala 115 120 125 Cys Arg Ile Leu Glu Arg Tyr Cys Gln Gin Val Leu Lys Lys Gly 130 135 140 INFORMATION FOR SEQ ID NO:1638: SEQUENCE CHARACTERISTICS: LENGTH: 577 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein iii) HYPOTHETICAL: YES vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...577 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1638 Lys Asn Glu Asn Phe Ile-Lys Val Leu Ile Leu Asp Leu Lys Val Leu 1 5 10 Leu Gin Arg Ile Val Asp Phe Phe Ile Lys Leu Asn Lys Lys Gin Lys 25 lie Ala Leu Ile Ala Ala Gly Val Leu Ile Thr Ala Leu Leu Val Phe 40 Leu Leu Leu Tyr Pro Phe Lys Glu Lys Asp Tyr Ala Gin Gly Gly Tyr 55 Gly Val Leu Phe Glu Arg Leu Asp Ser Ser Asp Asn Ala Leu Ile Leu 70 75 Gin His Leu Gin Gin Asn Gin Ile Pro Tyr Lys Val Leu Lys Asp Asp 90 Thr Ile Leu Val Pro Lys Asp Lys Val Tyr Glu Glu Arg Ile Thr Leu 100 105 110 1185 Ala Ser Gin Gly Ile Pro Lys Thr Ser Lys a. a a f a ft at ft ftf *ft f ft ft ft ft *ftt f f *r **ft f Asp Ile 145 Pro Phe Lys Leu Val 225 Ser Asn Gly Gin Ser 305 Val Leu Thr Gly Lys 385 Ser Gly Phe lle Lys 465 Ile Lys Leu Leu Glu 545 Leu Gly Thr Lys Asp 130 Arg Ala Ile lle Leu Lys Val Ala Lys 180 Pro Asp Met 195 Ile Ala Ala 210 Asn Glu Asn Lys Glu Leu Ile Leu Glu 260 Lys Asn Lys 275 Lys Lys Ser 290 Glu Gin Asn Gly Gly Val Lys Asp Asn 340 Asn Tyr Glu 355 Thr Leu Met 370 Ile Ala Leu Asp Glu Ser Asp Asn Gin 420 Asn Pro Met 435 Met His Lys 450 Tyr Ile Leu Val Pro Phe Glu Val Lys 500 Asn Lys Leu 515 Asn Ala Ser 530 Lys Ile Arg Phe Lys Leu Phe Glu Ala 165 Glu Lys Ala Gly Ala 245 Asn Val Thr Leu Pro 325 Lys Val Arg Glu Leu 405 Asn Ala Thr Val Ser 485 Ser Gly Phe Gly Leu 565 Gly Gly 150 Asn Val Leu Val Glu 230 Leu Lys Val Lys Glu 310 Gly Glu Gly Leu Asp 390 Lys Arg Pro Gin Phe 470 Glu Met Asp Ser Thr 550 Ile Ala 135 Glu Val Pro Ser Pro 215 Ser Glu Ile Ala Glu 295 Glu Val Pro Lys Asn 375 Gly Lys Gly Met Lys 455 Ile Arg Phe Leu Glu 535 Leu Lys 120 Thr Leu His Pro Pro 200 Lys Ile Gin Val Arg 280 Thr Lys Val Glu Thr 360 Ala Ala Ile Asp Ile 440 Ile Val Met Glu Arg 520 Glu Lys Asp Asp Ser Ile Ser 185 Thr Leu Gly Leu Asn 265 Val Phe Lys Ser Lys 345 Ile Ala Asn Asn Asp 425 Asp Leu Leu Leu Glu 505 Lys Glu Glu Glu Phe Arg Ala 170 Ala Gin Thr Glu Arg 250 Ile Asn Asp Glu Asn 330 Tyr Ile Val Ala Ala 410 Val Asn Gly Phe Glu 490 Met Lys Val Arg Ile 570 Val Asp Thr 155 Ile Ser Ile Ile Gly 235 Tyr Leu Ala Pro Gly 315 Ile Glu Glu Val Leu 395 Leu Ala.
Ala Ser Ile 475 Val Asp Val Arg Pro 555 Ser Gly Gin 140 Ile Pro Val Leu Glu 220 Asp Lys Ala Glu Asn 300 Ala Gly Lys Ile Val 380 Glu Val Val Thr Phe 460 Phe Val Glu Glu Tyr 540 Asp Ser Phe 125 Asn Glu Lys Met Gly 205 Asn Ile Gin Pro Phe 285 Asn Pro Pro Ser Lys 365 Asp Tyr Lys Ser Leu 445 Thr Tyr Pro Glu Asp 525 Glu Glu Asp Glu Ile Ser Asp Leu 190 Ile Val Leu Asn Ile 270 Asp Val Lys Val Gin 350 Gly Gly Glu Gin Asn 430 Ser Pro Lys Asp Glu 510 Gin Ile Ile Ser Ile Lys Leu Ser 175 Lys Lys Lys Glu Phe 255 Val Phe Val Lys Gin 335 Asn Glu Lys Pro Ala 415 Phe Glu Leu Lys Glu 495 Asp Leu Ile Ala Ala 575 Phe Leu Asn 160 Val Leu Asn Ile Asn 240 Glu Gly Ser Arg Gin 320 Gly Thr Phe Tyr Leu 400 Ile Glu Lys Ile Val 480 Asp Glu Gly Leu Thr 560 Lys INFORMATION FOR SEQ ID NO:1639: SEQUENCE CHARACTERISTICS: 1186 LENGTH: 199 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc feature LOCATION 1 .199 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1639 Lys Trp Cys Gly Tyr Cys Glu Arg Arg Ser Val Arg Arg Gly Tyr Tyr 1 5 10 Arg Ser Arg Lys Arg Leu Thr Lys Asn His His Ala Phe Ala Cys Ser 25 Leu Asp Phe Ile Tyr Pro Thr Asn Asn His Lys Val Ile Gin Glu Ile 40 Ala Gln Asn Gly Leu Ile Leu Ser Glu His Giu Lys Asp Phe Met Phe 55 Ile Lys Gly Phe Phe Leu Val Arg Asn Cys Leu Val Ile Ala Leu Thr 70 75 Asp Ala Vai Ile Ile Pro Gin Ala Asp Leu Lys Ser Gly Ser Met Ser 90 Sen Val Arg Leu Ala Gin Lys Tyr Gin Lys Pro Leu Phe Val Leu Pro -9.,*100 105 110 *Gin Arg Leu Asn Glu'Ser Asp Gly Thr Asn Giu Leu Leu Glu Lys Gly 115 120 125 999Gin Ala Gin Gly Ile Phe Asn Ile Gin Asn Phe Ile Asn Thr Leu Leu 9130 135 140 Lys Asp Tyr His Leu Lys Giu Met Pro Glu Met Lys Asp Glu Phe Leu 145 iso 155 160 *9Giu Tyr Cys Ala Lys Asn Pro Ser Tyr Glu Giu Ala Tyr Leu Lys Phe 165 170 175 Gly Asp Lys Leu Leu Giu Tyr Glu Leu Leu Gly Lys Ile Lys Arg Ile 180 185 190 '.Asn. His Leu Val Val Leu Ala 4. 195 INFORMATION FOR SEQ ID NO:1640: SEQUENCE CHARACTERISTICS: LENGTH: 276 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc feature LOCATION .276 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1640 1187 Arg Leu Lys Met Ala Thr Lys Leu Thr Pro Lys Gin Ly's Ala Gin Leu 1 Asp Gly Ile Gin Asn Thr Thr Lys Ile 145 Leu Ala Val Giy Ser 225 Ala Leu Lys Giu Glu Thr s0 Ile Gin Arg Lys Pro 130 Ala Ser Asn Leu Gly 210 Ala G.1y Asp Thr Leu Asp Giu Gly Thr Ser 115 Gin Leu Tyr Leu Glu 195 Leu
LYS
Ala Asn Gly 275 Ser Thr Ile Ala Ile Leu 100 Leu Gin Ile Phe Gly 180 Asn Arg Thr Ile Phe 260 Leu s Met Thr Ser Ala Asn Gly Gin Leu Leu Pro 165 Glu Lys Al a Thr Lys 245 Ala Ser Giy Lys Val 70 Thr Ser Thr Ala Ala 150 Asp Ile Leu Val1 Leu 230 G iu Ile Giu Giu Gin 55 Leu Gly Giu Gin Asp 135 His Giu Ser Giu Al a 215 Ala Met Met Lys Ile 40 Ile Giu Gly Giu Lys 120 Phe Met Met Pro Ser 200 Glu Arg Met Arg Ile 25 Leu Val1 Giu Leu Ala 105 Asn Ile Glu Lys Gin 185 Leu Ile Ile Phe Asp 265 10 Ala Arg Gin Phe Giu 90 Arg Phe Ile Ala Ala 170 Val1 Thr Phe Glu Thr 250 Phe Ile His Leu Phe Tyr Lys Ala As n Pro 155 Giu Val1 Ser As n Ser 235 Phe Lys Leu Leu Asn Ala Ala Val1 Tyr Glu 140 Asn Ile Lys Tyr Arg 220 Val1 Giu Ser Leu Asp Gly Ile Arg Met Leu 125 His Ala Ser Arg Lys 205 Leu Asp Asp Gly Ile Ile Thr Phe Giu Asp 110 Gly Pro Ala Ile Val1 190 Ile Gly Asn Ile Gly 270 Gin Asp Asp Gin Leu Lys Lys Gin Giu Arg 175 Ser Giu Gin Lys Ala 255 Leu 0* INFORMATION FOR SEQ ID NO:1641: SEQUENCE CHARACTERISTICS: LEGTH: 194 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .194 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1641 Arg Ser Leu Gly Lys Gly Arg Pro Met Asn Lys Lys Asn Sen Val Ile 1 5 10 Sen Gly Leu Met Asn Phe Phe Ser Giu Lys Asn Giu Arg Trp Leu Leu 25 Ala His Arg His Thr Ang Gly Phe Val Ile Val Ala Trp Leu Phe Ang 35 40 Phe Lys Ser Ile Ala Phe Sen Ile Leu Ile Thn Leu Leu Val Ile Leu 1188 55 Val Asp Ile Trp Val Tyr Ser Asp Val Arg Gln Phe Leu Leu Asp Thr 70 75 Ser Ser Ser Phe Ile Trp Leu Leu Ile Ala Leu Leu Ile Lys Trp Gly 90 Val Ile Val Ile Ser Ala Arg Lys Cys Tyr Gin Phe Ser Gin Lys Met 100 105 110 Phe Ala Leu Ile Gin Arg Lys Arg Gin Ile Arg Glu Asn Leu Lys Asn 115 120 125 Arg Ser Asn Arg Lys Asp Ala Lys Asn Phe Glu Lys Leu Ser Asn Ile 130 135 140 Ala Glu Glu Ile Ile Ser Lys Lys Gin Glu Glu Ser His His Lys Glu 145 150 155 160 Asp Ser Asn Asp Glu Asn His Lys Asp Lys Leu Ser Asn Ile Thr Glu 165 170 175 Glu Met Ile Leu Lys Lys Gin Glu Glu Leu Lys Ala Arg Lys Asp Lys 180 185 190 Gly Asp INFORMATION FOR SEQ ID NO:1642: SEQUENCE CHARACTERISTICS: LENGTH: 539 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...539 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1642 Leu Met Asp Arg Ala Lys Phe Ile Phe Val Thr Gly Gly Val Leu Ser 1 5 10 Ser Leu Gly Lys Gly Ile Ser Ser Ser Ser Ile Ala Thr Leu Leu Gin 25 His Cys Asn Tyr Gin Val Ser Ile Leu Lys Ile Asp Pro Tyr Ile Asn 40 Ile Asp Pro Gly Thr Met Ser Pro Leu Glu His Gly Glu Val Phe Val 55 Thr Ser Asp Gly Ala Glu Thr Asp Leu Asp Ile Gly His Tyr Glu Arg 70 75 Phe Leu Asn Arg Asn Leu-Thr Arg Leu Asn Asn Phe Thr Thr Gly Gin 90 Ile Phe Ser Ser Val Ile Glu Asn Glu Arg Lys Gly Glu Tyr Leu Gly 100 105 110 Lys Thr Ile Gin Ile Val Pro His Val Thr Asp Glu Ile Lys Arg Arg 115 120 125 Ile Lys Ser Ala Ala Lys Gly Leu Asp Phe Leu Ile Val Glu Val Gly 130 135 140 Gly Thr Val Gly Asp Met Glu Gly Met Phe Tyr Val Glu Pro Ile Arg 145 150 155 160 Gin Leu Lys Leu Glu Leu Arg Asn Lys Ala Leu Ile Asn Met His Val 165 170 175 Thr Leu Met Pro Tyr Ile Arg Ala Thr Ser Glu Leu Arg Ser Arg Pro 180 185 190 1189 Thr Gin His 195 Ser Val Gin Giu Leu Arg Arg Leu Gly Val Thr Pro Gin 200 205
S
*e S. S. 55
S
S
S S S.
S.
S *SS S Ile Lys 225 Thr Gly Pro Lys Giu 305 Leu Giu Phe Arg Ala 385 Ser Giu Ser Met Glu 465 Trp Ile Phe Leu Ile 210 Ile Asp Ile Lys His 290 Ser Asp Lys Gly Leu 370 Ile Thr Asp Pro Pro 450 Arg Giu Giu His Asp 530 Leu Ala Thr Leu Met 275 Lys Tyr Thr Thr Giu 355 Giu Val Giu Phe Leu 435 Asn His Asn Ala Pro 515 Phe Ala Leu Lys Thr 260 Ala Val Lys Gin Asp 340 Arg Lys Giu Phe Met 420 Gly Ser Arg Lys Ile 500 Giu Ile Arg Ser Ser 245 Pro Ala Lys Ser Val1 325 Leu Gly Leu Phe Asn 405 Asp Gly Leu His Gly 485 Glu Phe Lys Ser Cys 230 Ile Ile Trp Ile Leu 310 Asn Giu Ile Pro Cys 390 Gin Gin Thr Leu Arg 470 Leu Leu Thr Ser *Pro 215 Asp Tyr Ala Asn Gly 295 Ile Ile Gly Giu Phe 375 Arg Arg Asn Met Giu 455 Tyr Lys Giu Ser Ala 535 Lys Val1 Ala Arg Thr 280 Phe Giu Giu Val1 Giy 360 Leu Asn Cys His Arg 440 Lys Giu Val Asp Arg 520 Leu Pro Giu Cys Arg 265 Leu Val1 Ala Trp Asp 345 Lys Gly Val1 Giu Gin 425 Leu Ala Ile Val His 505 Leu His Leu Gin Pro 250 Phe Vali Gly Leu Leu 330 Ala Ile Ile Leu Tyr 410 Lys Gly Tyr Asn Gly 490 Pro Gin Lys Asp Asp 235 Ile Asn G iu Lys Ile 315 Asp Ile Cys Cys Gly 395 Pro Gin Glu Lys Pro 475 Phe Phe Ser Ser Lys 220 Ser Leu Leu Lys Tyr 300 His Ser Leu Aia, Leu 380 Leu Val1 Val1 Lys 460 Lys Giy Phe Pro Giu Val1 Phe Asn Ile 285 Leu Aia Giu Val1 Ile 365 G iy Lys Val1 Arg Giu 445 Pro Tyr Ala Val Asn 525 Leu Ile Leu Lys 270 Ile Ser Gly Asn Pro 350 Gin Met Giy Tyr Thr 430 Cys Asn Arg Asn Giy 510 Pro Lys Lys Val Ala 240 Gin Giu 255 Leu His Ala Pro Leu Lys Ala His 320 Phe Asn 335 Gly Gly Arg Ala Gin Leu Aia Asn 400 Leu Ile 415 Tyr Asn Giu Ile Ile Lys Gin Giu 480 His Leu 495 Val Gin Ile Ile
INFORMATION
FOR SEQ ID N0:1643: SEQUENCE CHARACTERISTICS: LENGTH: 369 amino acids TYPE: amino acid TOPOLOGY: -linear (ii) MOLECULE TYPE. protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc -feature LOCATION 1. 369 1xi) SEQUENCE DESCRIPTION: SEQ ID NO:1643 1190 Ile 1 Trp Arg Gly
S
S. Phe Glu Glu Glu Gin Leu Lys Ile Arg 145 Gly Asp Phe Ser Phe 225 Ala Lys Ile Glu Asn 305 Asp Thr Gin Leu Ala Phe Ala Leu Lys Thr Glu Lys 130 Asp Asn Ser Asn Glu 210 Lys Leu Leu Glu Gly 290 Tyr Gly Met Asp Arg Ser Ser Ser Thr Thr Val 115 Glu Lys Val Ala Ile 195 Asn Leu Leu Gin Ser 275 Glu Asn Lys Asn Asn 355 Tyr His Leu Lys Glu Leu 100 Asn Val Arg Phe Asp 180 Ile Lys Thr Asn Asp 260 Thr Pro Ile Glu Asp 340 Asn Cys Thr Leu Phe Asn Ala Gin Ser Glu Asp Lys 165 Phe Asp Gly Asn Val 245 Tyr Asn Val Lys Ile 325 Ile Thr Lys Lys Thr Ala 70 Leu His Leu Asn Glu 150 Ser Asp Gly Gly Ile 230 Tyr Ile Ala Glu Asn 310 Ala Ile Glu Gly Ser His Asp Arg Val His Asp Glu Phe Val Ala Glu Asp 55 Lys Thr Lys Gly Asn 135 Leu Ser Glu Ser Leu 215 Thr Asn Asp Ile Phe 295 Gly Arg Gin Asn Asn Ala 40 Leu Asp His Ala Ser 120 Lys Glu Ile Ser Ile 200 Asn Asp Asp Leu Tyr 280 Asn Ser Lys Val Asp 360 Tyr Glu 25 Ser Ala Gin Asp Ser Ala Asn Ile 90 Ser Glu 105 Gin Ile Ser Leu Phe His Lys Thr 170 Tyr Asn 185 Phe His Gin Val Lys Leu Gly Ser 250 Leu Asp 265- Ala Gin Ser Asp Phe Asp Thr Ile 330 Ile Asn 345 Phe Asp ASn Tyr Tyr Gin 75 Lys Glu Ala Lys Leu 155 His Leu Pro Tyr Asn 235 Asn Ser Ser Glu Leu 315 Ala Ala Glu Thr Phe Phe Lys Asp Leu Glu His 140 Arg Ser Asn Leu Phe 220 Gin Gly Phe Ala Ala 300 Ile Ile Asn Leu Tyr Pro Asn Gin Thr Lys Ile 125 Ala Glu Leu Ile Va1 205 Gin Gly Thr Ala Ser 285 Phe Ala Thr Thr Phe 365 Tyr Asp Ser Ala Arg Ser 110 Asn Asn Leu Thr Gly 190 Va1 Ser Lys Leu Arg 270 His Lys Tyr Pro Asp 350 His Asp Ile Trp Leu Glu Val Lys Glu Leu Asp 175 His Lys Asp Va1 Lys 255 Gly His Asp Asn Ile 335 Asp Ser Thr Asp Lys Ala Arg Ile Arg Leu Gly 160 Lys Gly Glu Asp Gly 240 Gly Leu Ile Thr Thr 320 Thr Asn Glu INFORMATION FOR SEQ ID NO:1644: i) SEQUENCE CHARACTERISTICS: LENGTH: 271 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori 1191 (ix) FEATURE: NAME/KEY: misc feature LOCATION .271 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1644 Thr Lys Leu Val Phe Met Ile Lys Ala Arg Phe Lys Lys Arg Leu *bS.
a.
Lys 1 Leu C lu Thr Ile Leu Leu Lys Asn Arg 145 Leu Gin Leu Leu Phe 225 Cys Leu Gly Ala Ile Giu Lys Phe Asp Leu 130 Val1 Asp Gin Val Phe 210 Ser His Asn Ser Glu Leu Ala Pro Pro Lys 115 Ser Ala Glu Gly Ser 195 Leu Asn Tyr Pro Arg Val1 Arg As n Gin His 100 Asn Gin Leu Pro Leu 180 His Asn Arg Glu Thr 260 Gly Val1 Ile His Gin Leu Lys Gin Ala Leu 165 Leu Asp Asn Leu Val 245 Phe Ala Ala Leu Ser 70 Arg Asn Ile Lys Arg 150 Asn Asp Pro Gly Leu 230 Ile Lys Phe Leu Ala 55 Val1 Lys Val1 His Ile 135 Ala Ala Phe Asn Val 215 Val1 Pro Leu Asp Leu 40 Gly Trp Ile Tyr Giu 120 Pro Leu Leu Ile Giu 200 Ile Lys Gin Asp Leu 25 Gly Leu Leu Gly Gin 105 Val Lys Ile Asp Lys 185 Ile Asp Pro Thr Phe 265 10 Asn Glu Glu Asp Phe 90 As n Leu Leu Ala Asn 170 Arg Thr Pro Leu Ile 250 Ile Ile Ser Ala Thr 75 ValI Ile Arg Ser Ala 155 Ala Glu Lys Asn Phe 235 Ser Gin.
Asp Gly Val Gin Phe Ala Leu Gly 140 Lys Leu Asn Leu Gin 220 Glu Leu Asn Leu Ala Ser Lys Gin Phe Met 125 Gly Asn Lys Leu Ala 205 Giu Asp Pro Lys Glu Gly Ser Lys Asp Ala 110 Arg Gin Leu Asn Ser 190 Arg Asn Glu Lys Lys 270 Ile Lys Gly Ile Tyr His Leu Ala Leu Giu 175 Val1 Thr Arg Asn Asp 255 Phe Lys Ser Tyr Phe Ala Pro G iu Gin Leu 160 Val Leu Phe Leu 240 Cys
INFORMATION
FOR SEQ ID NO:1645: SEQUENCE
CHARACTERISTICS:
LENGTH: 71 amino acids TYPE: amaino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .71 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i645 Leu Ser Ala Thr Ile Leu Gly Met Trp Ile Met Ser Ser Leu Ser 5 10 Sen Phe Phe His Ser Leu Phe Phe Ile Lys Sen Asn Pro Gly Gin Gly 1 Sen 1192 25 Leu Leu Lys Gly Trp Giy Ser Lys Ile Phe Phe Ile Asn Arg Lys Phe 40 Val Leu Ala Gin Tyr Asn Pro Ser Val Ser Ile Phe Ile Leu Leu Asn 55 Arg Val Phe Giy Val Giy Val INFORMA.TION FOR SEQ ID NO:i646: SEQUENCE CHARACTERISTICS: LENGTH: 75 amino acids TYPE: amino acid TOPOLOGY: iinear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) OR2GINAL
SOURCE:
ORGANISM: Heiicobacter pyiori (ix) FEATURE: NAME/KEy: misc-feature LOCATION Cxi) SEQUENCE DESCRIPTION: SEQ ID NO:i646 Sle Gin Arg Ser His Gin Leu Phe Asn Leu Gin Giu Lys Lys Gly Ile i S 10 Leu Gly Phe Leu His Gin Lys Asn Ile Leu Asn Ile Ala Gin Asn Asp 25 Sle His Gin Leu Leu Ile Leu Met Val Vai Phe Ser Met Leu Aia Thr- 40 Pro Phe Ile Leu Lys Tyr Leu Giu Ser Ile Ala Gin Phe Ile Leu His 55 Gin Lys Ser Gin Giu Asn Giu Pro Ala Lys Lys 70 INFORMATION FOR SEQ ID NO:i647: Ci) SEQUENCE
CHARACTERISTICS:
LENGTH: 117 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .117 (Xi) SEQUENCE DESCRIPTION: SEQ ID NO:i647 Gly Leu Met Ag Ile Ile Ile Arg Leu Leu Ser Phe Lys Met Asn Ala 1 5 10 is Phe Leu Lys Leu Ala Leu Ala Ser Leu Met Gly Gly Leu Trp Tyr Ala 25 1193 Phe Asn Gly Glu Gly Ser Glu Ile Val Ala Ile Gly Ile Phe Val Leu 40 Ile Leu Phe Val Phe Phe Ile Arg Pro Val Ser Phe Gin Asp Pro Glu 55 Lys Arg Glu Glu Tyr Ile Glu Arg Leu Lys Lys Asn His Glu Arg Lys 70 75 Met Ile Leu Gin Asp Lys Gin Lys Glu Glu Gin Met Arg Leu Tyr Gin 90 Ala Lys Lys Glu Arg Glu Ser Arg Gin Lys Gin Asp Leu Lys Glu Gin 100 105 110 Met Lys Lys Tyr Ser 115 INFORMATION FOR SEQ ID NO:1648: SEQUENCE CHARACTERISTICS: LENGTH: 109 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein o*o (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...109 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1648 Arg Lys Lys Met Glu Ile Ile Leu Leu Ile Val Ala Ala Val Val Leu 1 5 10 Phe Tyr Phe Tyr Asn Thr Leu Lys Glu Tyr Leu Lys Asn Pro Leu Asn 20 25 Pro Lys Thr Lys Thr Glu Glu Tyr Asp Leu Lys Asn Asp Pro Tyr Leu 40 Leu Val Gin Ser Ser Pro Leu Asp Lys Phe Lys Gin Thr Gin Ile Gly 55 Ala Tyr Met Arg Leu Leu Lys Phe Leu Asp Ile Gin Lys Asn Ala Leu 70 75 Asp Asn Ala Leu Arg Thr Leu Phe Ile His Glu Leu Glu Gin Pro Leu 90 Asn Ser Glu Gin Gin Asn Leu Gly Gin Arg Ala Ser Gin 100 105 INFORMATION FOR SEQ ID NO:1649: SEQUENCE CHARACTERISTICS: LENGTH: 543 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: 1194 NAME/KEY: misc-feature LOCATION .543 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1649 Met Pro Asn Asn Ala Leu Leu Gin Ile Lys Gin Asp
*U
I
Ile Gly Cys Ile Leu Leu Lys Phe Val 145 Ser Asn Tyr Tyr A-sn 225 Gly Thr Leu Giu Lys 305 Asn Vai Leu Ala Asn 385 Ile Ile Asp Thr Asn 465 Asp Asn Asp Arg Thr Asn Leu Asnr 130 Ser Leu Leu Leu Tyr 210 Lys Thr Leu Asn Gly 290 Met Giu Pro Phe Ile 370 Lys cys Ile Ala 450 Asp Giy Lys Asp Leu Tyr Asp 115 Thr Gin Leu Gin Leu 195 Thr Pro Leu Tyr Leu 275 Asn Asp His As n Phe 355 Ile Asn Met Phe Ser 435 Leu Leu Tyr Phe Tyr Ser Leu 100 Ala Lys Tyr Asp Asn 180 Lys Pro Thr Leu Ala 260 Ile Thr Phe Ala Ile 340 Gin Val Val Pro Phe 420 Lys krg 5 Lys *Lys Giu *Lys Asp Phe Ile Ser Ile Lys 165 Gin Asp Leu Gin Met 245 Gin Leu Leu Ile Giu 325 Pro His Pro Arg S er 405 Gin Leu Pro Val Ile Ile Ile Phe Phe 55 Asp Phe 70 Lys Lys Glu Lys Phe Asn Thr Asp 135 Asn Glu 150 Leu Lys Gin Gly Tyr Asn Ser Ile 215 Ser Val 230 Ala Leu Asp Ile Asn Asp Thr Asn 295 Val Ser 310 Ile Ser Lys Asn Cys Leu Thr-Giy 375 His Leu 390 Gin Val Lys Thr Gly Giu Ser Asp 455 Ser Asp 470 Cys Thr 40 Phe Asn Leu His Arg 120 Giu Gly Asn Tyr Asn 200 Ala Lys Ala Ser Leu 280 Pro Asn Gin Asp Asn 360 Phe Vai Phe Pro Glu 440 Met Phe Lys 25 Gin Giu Giu Pro Phe 105 Ile Thr Ser Phe Asp 185 Asn Ser Ile His Gin 265 Thr Tyr Pro Asn Lys 345 Met Ile Asp Ala Ser 425 Tyr Asp Cys 10 Asp Cys Gin Giu Lys 90 Tyr Ser Thr Lys As n 170 Phe Ser Ile Tyr Gin 250 Lys His His Pro
LYS
330 Ser Leu Ser Giu Asn 410 Ala Thr Leu Ala Ala Phe Lys Glu 75 Leu Asp Ser Ile Arg 155 Phe Phe Gly Ile Asp 235 Ile Ser Ser Ser Phe 315 Asn Lys Ser Aia Arg 395 Thr Lys Giu.
Ile Leu 475 Gly Leu Phe Lys Ala As n Asn Ala 140 Ala Lys Ala Gly Ala 220 Pro Gly Leu Leu Lys 300 Lys Asp Met Pro Lys 380 Leu Gly Giu Asn Leu 460 Val Thr Leu Tyr Pro Glu Tyr Aso Asn 125 Leu As n Gin Pro Thr 205 Lys Ser Thr Arg Arg 285 Asp Leu Phe Pro Lys 365 Ser Val Thr Val Lys 445 Giu Ser Leu Ala Lys Asn Tyr Asp Leu 110 Ala Phe Phe Ala Ile 190 Tyr Leu Aia Asp Met 270 His His Asp Phe Ile 350 dly Gly Tyr Asn Ile 430 Asn Thr Phe Ser Phe Lys Phe Giu His Glu Giu Thr Phe 175 Phe Ala Leu Gly Ser 255 Leu Ala Lys Phe Leu 335 Tyr Lys Val Gly Vai 415 Leu Lys Phe Asp *Leu *Asp Leu Thr Phe Leu Leu Leu Ser Arg 160 Leu Giu Glu Val Thr 240 Cys Lys Ile Gly Ser 320 Gly Thr Gly Asn Val1 400 Ser Ile Lys Gin Giu 480 Lys Aia Pro Lys 1195 Ile Thr Glu Lys Asn Tyr Ser Leu Asn Pro Gly Gin Tyr Phe Thr Ile 485 490 495 Glu Asp Thr Ser Glu Thr Ile Ser Gin Ala Glu Phe Glu Asn Leu Met 500 505 510 Gin Gin Tyr Ser Ser Glu Leu Ala Ser Leu Phe Asp Glu Ser Gin Asn 515 520 525 Leu Gin Gin Glu Ile Leu Glu Thr Leu Lys Gly Val Arg Phe Glu 530 535 540 INFORMATION FOR SEQ ID NO:1650: SEQUENCE CHARACTERISTICS: LENGTH: 192 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...192 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1650 Lys Gly Asp Phe Met Lys Glu Gin Glu Trp Asp Leu Ser Ala Leu Phe 1 5 10 Glu Asn Lys Glu Ser Ala Glu Glu Phe Leu Lys Thr Leu Gin Thr Glu 20 25 Val Gin Glu Phe Glu Asn Ala Tyr Gin Asn Asn Leu Lys Asn Leu Asp 40 Ala Ala Lys Phe Ala Asn Thr Leu Lys His Tyr Glu Asn Leu Ser Glu 50 55 Lys Ile Ser Arg Ala Met Ala Tyr Ala Gin Leu Leu Phe Ala Lys Asn 65 70 75 Thr Lys Glu Ala Lys Phe Tyr Ser Gin Cys Glu Met Ala Cys Ala Asn 90 Ile Gin Gin His Leu Leu Phe Phe Glu Ile Glu Phe Lys Asn Leu Asp 100 105 110 Ala Lys Lys Gin Leu Ala Phe Ile Lys Lys Cys Lys Asp His Ala Phe 115 120 125 Tyr Leu Asn Asn Leu Ile Glu Lys Lys Lys His Thr Leu Asn Leu Asp 130 135 140 Glu Glu Lys Ile Ala Leu Ala Leu Ser Pro Val Gly Val Gly Ala Phe 145 150 155 160 Ser Phe Val Met Asp Glu His Leu Phe Ser Leu Asn Ile Ser Leu His 165 170 175 Arg Ile Asn Phe Lys Arg Arg Ile Asn Phe Ser Pro Leu Ala Gin Pro 180 185 190 INFORMATION FOR SEQ ID NO:1651: SEQUENCE CHARACTERISTICS: LENGTH: 155 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein 1196 (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...155 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1651 Ala Lys Glu Leu Leu Asn Glu Pro Val Asp Lys Lys Glu Asn Phe Glu 1 5 10 Ser Leu Cys Gln Glu Ile Ala Asp His Thr His Gly Glu Tyr Thr Lys 25 30 Arg Leu Lys Leu Val Glu Phe Leu Met Leu Leu Ala Tyr Ala Asp Gly 40 Ile Leu Asp Ser Lys Glu Lys Glu Leu Phe Leu Asp Val Gly Ala Phe 55 Leu Gin Ile Asp Asn Gln Asp Phe Asn Glu Leu Tyr Asp Asn Phe Glu 70 75 His Phe Asn Ser Ile Glu Ile Pro Met Ser Leu Glu Glu Ala Lys Asn 85 90 95 Leu Phe Glu Ile Gin Thr His Thr Thr Met Gln Asp Leu Glu Lys Lys 1" 100 105 110 Ala Leu Asp Leu Ser Ala Pro Tyr Tyr His Lys Met Asn Asp Asn Lys 115 120 125 S Arg Tyr Ser Glu Gin Asp Phe Ile Ser Leu Lys Lys Ile Ala Leu Ala 130 135 140 Ser Gin Leu Leu Glu Asn Asp Leu Lys Asp Ser 145 150 155 INFORMATION FOR SEQ ID NO:1652: C(i) SEQUENCE CHARACTERISTICS: LENGTH: 405 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
0 (vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...405 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1652 Met Pro Phe Leu Lys Ala-Leu Ala Ser Phe Asp Ala Pro Phe Leu Glu 1 5 10 Lys Glu Ile Ser Lys Arg Phe Arg Asp Asn Leu Val Phe Phe Lys Ser 25 30 Tyr His Pro Asn Leu Phe Asn Ala Leu Asn Thr Pro Phe Lys Asn Tyr 40 45 Gin Leu Leu Phe Glu Thr Asn His Leu Asn Leu Leu His Thr Pro Thr 55 60 Asn Ala Leu Ser Tyr Pro Lys His Gln Met Ile Glu Thr Ala Phe Asn 70 75 Met Ala Lys Asn Pro Leu Asn Asn Pro Arg Trp Ser Leu Asp Asn Asn 90 1197 His Leu Ser Leu His Tyr Leu Lys Ser Gin Asn Asn His Lei Gli Gli 145 Arg Ile Lys Phe Pro 225 Tyr Leu Lys Gly Lys 305 His Leu Gly Leu Tyr 385 Gly u Thr I Thr 130 y Val SPhe SSer SLeu Leu 210 Tyr Tyr Gly Thr Pro 290 Phe Gly Lys Ala 1 Met 370 Arg Phe 100 Leu 115 Pro Leu His Cys Phe 195 Lys Lys Lys Val Lys 275 Ser Ile Val Glu Asn 355 ?he Ile Asp Lys Cys Asp Ser Tyr 180 Ile Arg Ser Gin Lys 260 Pro Leu Ile Lys Val 340 Met Met Arg Glu SAla SSer Gly SLeu 165 SPhe SGin Pro Ala Ala 245 Asn Lys Asp Phe Val 325 Leu Leu Arg Ser Arg 405 Thr Leu Leu 150 Tyr Ala Gly Ile Phe 230 Leu Thr Lys Leu Ser 310 Asp Glu Asn Gly Ala 390 His Lys 135 Phe Leu Arg Phe Thr 215 Asn Arg Leu Ile Leu 295 Cys Phe Arg Pro Gly 375 Ala 120 Lys Leu Phe Tyr Phe 200 His Leu Gly Lys Asn 280 Leu Gly Gin Ala Asn 360 Ser 105 Ile Phe Ala Glu Glu 185 Asn Ser Arg Trp Asn 265 Ala Asp Thr Ile Pro 345 Ala Ala Ser Leu Ile Glu 170 Asp Pro Phe Met Gly 250 Leu Pro Phe Ala Glu 330 Leu Phe Cys SAsn Pro Leu 155 Asn Leu Asn Leu Arg 235 Ser Pro Ile Leu Leu 315 Val Glu Asp Ala Phe Pro 140 Gin Leu Ile Glu Lys 220 Glu Phe Leu Cys Lys 300 Lys Glu Asp Leu Tyr 380 Leu 125 Thr Ala Asp Lys Leu 205 Leu Asn Glu Cys Val 285 Glu Pro Arg Thr Ala 365 Lys Lys 110 SAsp Met Gin Leu Lys 190 Lys Glu Ile Asp Gin 270 Val Asn Leu Ile Pro 350 Lys Pro Leu Asn Ile Asn Phe 175 Gly Met Ile Gin Glu 255 Thr Gly Glu Lys Asp 335 Leu Glu Phe Pro His Tyr Tyr 160 Lys Ala Asp Met Ser 240 Leu Leu Asn Glu Ala 320 Tyr Met Ala Glu 9 9999 99 .99.
99** 9 9* 9 9 999 9 Phe Giu Phe Cys Gly Gin Cys Arg Gly Gly Phe Ser 395 INFORMATION FOR SEQ ID NO:1653: SEQUENCE CHARACTERISTICS: LENGTH: 413 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...413 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1653 Lys Gly Leu Gly Leu Ser Glu Trp Gin Thr Phe Cys Leu Lys Asp Leu 10 Gly Lys Ile Val Gly Gly Ala Thr Pro Pro Thr Asn Asn Pro Lys Asn 1198 25 Tyr Gly Asn Lys Ile Ala Trp Ile Thr Pro Lys Asp Leu Ser Thr Leu 40 Gin Gly Arg Tyr Ile Lys Lys Gly Ser Arg Ser Ile Ser Arg Leu Gly 55 Phe Lys Ser Cys Ser Cys Val Leu Leu Pro Lys His Ala Ile Leu Phe 70 75 Ser Ser Arg Ala Pro Ile Gly Tyr Val Ala Ile Ala Glu Lys Arg Leu 90 Cys Thr Asn Gin Gly Phe Lys Ser Ile Ile Pro Asn Lys Lys Ile Tyr 100 105 110 Phe Glu Phe Leu Tyr Tyr Leu Leu Lys Tyr Tyr Lys Asp Asn Ile Ser 115 120 125 Asn Ile Gly Gly Gly Thr Thr Phe Lys Glu Val Ser Gly Ala Thr Leu 130 135 140 Gly Leu Phe Gin Val Lys Ile Pro Pro Thr Tyr Tyr Glu Gin Gin Lys 145 150 155 160 Ile Ala His Thr Leu Ser Ile Leu Asp Gin Lys Ile Glu Asn Asn His 165 170 175 Lys Ile Asn Glu Leu Leu His Lys Ile Leu Glu Leu Leu Tyr Glu Gin 180 185 190 'Tyr Phe Val Arg Phe Asp Phe Leu Asp Glu Asn Asn Lys Pro Tyr Gin 000 195 200 205 Thr Ser Gly Gly Lys Met Lys Phe Ser Lys Glu Leu Asn Arg Leu Ile SPr o210 215 220 Pro Asn Asp Phe Lys Val Lys Thr Leu Gly Glu Leu Ile Thr Trp Ile *e 225 230 235 240 Ser Gly Ser Gin Pro Pro Lys Ser Cys His Ile Tyr Glu Tyr Lys Glu 245 250 255 Gly Tyr Ile Arg Phe Ile Gin Asn Arg Asp Tyr Ser Ser Asn Asn Tyr 260 265 270 Val Thr Tyr Ile Pro Ile Ser Lys Asn Asn Lys Ile Cys Tyr Gin Tyr 275 280 285 Asp Ile Met Met Asp Lys Tyr Gly Glu Ala Gly Ser Val Arg Phe Gly 290 295 300 Leu Gin Gly Ala Tyr Asn Val Ala Leu Ser Lys Ile Ser Val Leu Asn 00 305 310 315 320 Gin Ser Met Gin Glu Tyr Ile Arg Ser Tyr Leu Asn Ser Lys Pro Ile 325 330 335 Lys Lys Tyr Leu Ser Asn Ala Cys Met Ala Ser Thr Arg Ala Ser Leu 340 345 350 Asn Glu Asn His Ile 'Tyr Ser Leu Met Leu Pro Ile Pro Pro Ile Asn 355 360 365 Leu Leu Gin Lys Tyr Glu Lys Ile Ala Lys Asn Ile Ile Thr Ala Ile 370 375 380 Ile Lys Asn Asn Gin Ser Thr Gin Thr Leu Thr Ala Leu Arg Asp Phe 385 390 395 400 Leu Leu Pro Leu Leu Leu Lys Gin Gin Val Lys Pro Gin 405 410 INFORMATION FOR SEQ ID NO:1654: SEQUENCE CHARACTERISTICS: LENGTH: 197 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori 1.199 (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 197 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i654 Gly Val Thr Leu Ile Gin Gin Giu Giy Phe Ile Met Ile Lys Arg Ile 1 5 10 Ala Cys Ile Leu Ser Leu Ser Ala Ser Leu Ala Leu Ala Gly Giu Val 25 Asn Gly Phe Phe Met Gly Ala Gly Tyr Gin Gin Gly Arg Tyr Giy Pro 40 Tyr Asn Ser Asn Tyr Ser Asp Trp Arg His Giy Asn Asp Leu Tyr Giy 55 Leu Asn Phe Lys Leu Gly Phe Val Giy Phe Ala Asn Lys Trp, Phe Gly 70 75 Ala Arg Val Tyr Gly Phe Leu Asp Trp Phe Asn Thr Ser Gly Thr Giu 90 His Thr Lys Thr Asn Leu Leu Thr Tyr Giy Gly Giy Gly Asp Leu Ile 100 105 110 Val Asn Leu Ile Pro Ser Asp Lys Phe Ala Leu Giy Leu Ile Gly Gly 115 -120 125 Val Gin Leu Ala Gly Asn Thr Trp Met Phe Pro Tyr Asp Val Asn Gin 130 135 140 Thr Arg Phe Gln Phe Leu Trp Asn Leu Gly Giy Arg Met Arg Val Gly 145 150 155 160 Asp Arg Ser Ala Phe Giu Ala Gly Val Lys Phe Pro Met Val Asn Gin 165 170 175 Gly Ser Lys Asp Val Gly Leu Ile Arg Tyr Tyr Ser Trp Tyr Val Asp 180 18S 190 Tyr Val Phe Thr Phe 195 INFORMATION FOR SEQ ID NO:i655: SEQUENCE CHARACTERISTICS: LENGTH: 366 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .366 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1655 The Arg Phe Tyr Phe Phe Lys Ala Asn Arg Ser Tyr Trp Gly Lys Val 1 5 10 Phe Met Val Asn Sen Thr Leu Tyr Ile Val Ile Ala Gly Leu Trp Leu 25 Ala Val Gly Phe Giy Ile Phe Leu Lys Lys Leu Asp Met Pro Val Ile 40 Ile Gly Tyr Ile Cys Thr Gly Thr Val Leu Ala Ala Phe Phe Lys Ile 55 Asn Asp Phe Asn Leu Leu Ser Asp Ile Gly Glu Phe Gly Ile Val Phe 70 75 Leu Met Phe Met le'Gly Ile Glu Phe Asn Phe Asp Lys Leu Lys Sen 1200 90 Ile Lys Gin Glu Vai Leu Val Phe Gly Leu Leu Gin Vai Vai Leu Cys 100 105 110 Ala Leu Ile Ala Phe Leu Leu Gly Tyr Phe Val Leu Giy Leu Ser Pro 115 120 125 Ile Phe Ser Leu Val Leu Gly Met Giy Leu Ser Leu Ser Ser Thr Ala 130 135 140 Ile Vai Leu Lys Phe Phe Giu Asp Ser Lys Gin Leu Ser Thr Pro Met 145 150 155 160 Giy Lys Ser Ala Val Gly Ile Leu Ile Phe Gin Asp Ile Ala Ala Ile 165 170 175 Pro Met Leu Leu Ile Leu Thr Ile Leu Gly Ser Lys Asp Ser His Val 180 185 190 Asn Leu Leu Ile Leu Lys Thr Leu Ile Ser Ala Gly Ile Ile Leu Ile 195 200 205 Leu Leu Leu Leu Pro Glu Lys Lys Gly Ala Asn Leu Ile Leu Giu Gin 210 215 220 Ala Lys Asp Thr Arg Leu Pro Giu Ile Phe Ile Gly Thr Val Leu Val 225 230 235 240 Ile Val Cys Ser Ala Ala Gly Leu Ser His Phe Phe Gly Phe Ser Met 245 250 -255 Ser Leu Gly Ala Phe Ile Val Gly Met Ala Ile Ser Lys Ser Arg Tyr 260 265 270 Lys Ile Asn Val Gin Glu Glu Phe Ala Gin Leu Lys Asn Leu Phe Leu 275 280 285 Ala Leu Phe Phe Ile Thr Ile Gly Met Gin Ile Asn Val Ser Phe Phe 290 295 300 Met Giu Lys Phe Phe Val Val Ile Phe Leu Leu Ile Leu Val Met Ser 305 310 315 320 Phe Lys Thr Phe Ile Ile Tyr Ala Leu Leu Arg Phe Phe Arg Asp Ala 325 330 335 Lys Thr Ala Ile Lys Thr Ala Leu Ser Leu Ala Gin Ile Gly Giu Phe 340 345 350 Ser Phe Val Ile Phe Leu Asn Ser Ala Leu Ala Pro Ala Leu 355 360 365 *o~p INFORMATION FOR SEQ ID NO:1656: Wi SEQUENCE CHARACTERISTICS: LENGTH: 242 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE:- NAME/KEY: misc-feature LOCATION 242 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i656 Cys Leu Cys Val Gly Gly Ala Leu Ala His Ile Sen Pro Leu Ser Ile 1 5 10 Giu Tyn Ala Ala Pro Phe Val Gly Asn Ala Gly Val Ala Leu Ala Gly 25 Leu Met Ser Asp Giu Ile Tyr Leu Cys Ala Leu Asp Cys Ala Tyr Ile 40 Lys Gly Phe Lys Lys His Ala Gin Asn Ser Tyr Tyr Gly Asp Giu Lys 55 1201 Giu Ile Asp Thr Ser Ser Leu Ile Ser Val Giu Giy 70 Tyr Giu Tyr
LYS
Met 145 Lys Pro Giy Phe Leu 225 Thr Giu Giu Gly Leu 130 Phe Asn Cys Phe Giu 210 His Pro Thr Ala Ala 115 Lys Ser Leu Lys Cys 195 Giy Leu Phe Leu 100 Lys Gin Pro Ile Thr 180 Gin Ser Lys Asp Tyr Lys Asn Ser 150 Phe Gin Ala Ala Asn 230 Leu Gin Ala 120 Gin His Giu Ala Ala 200 Ile Leu Phe Pro 105 Val1 Asp Ala Asp Phe 185 Lys Leu Thr Leu Lys Ser Ala Lys Phe 170 Giu Thr Gin Leu Leu Lys Leu Ile Asp 155 Phe Trp Pro Ser Leu 235 Ser Val1 Asn Val 140 Leu Thr Vai Thr Val1 220 Ser As n Lys Tyr His 125 Arg Lys His Asp Ile 205 Leu As n INFORMATION FOR SEQ ID NO-.i657:
S**S
S
S S *5 S *550
S
*5 S SEQUENCE CHARACTERISTICS: LENGTH: 319 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .319 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1657 Ile Leu Leu Val Giu Leu Lys Leu His Pro Lys Ile 1
LYS
Trp Thr Phe 65 Phe Leu Val Phe Phe Arg Leu Phe so Asn Ala
LYS
LYS
Asn 130 Asp Phe Asn 35 Lys His Leu Ile Glu 115 Ser Leu Sen Trp Ph1e Gly Phe Ala G lu Leu 135 Ala Gly Glu Lys Ile Ala Leu Leu Ile 125 Gin Lys 1202 145 Asp Leu Lys Pro Pro 225 His Ser Lys Gly Pro 305 Glu Val Asp Tyr 210 Ser Gin Leu Thr Ala 290 Lys Lys Leu Pro 195 Gly Leu Phe Ile Leu 275 Asn Ala Ile Trp 180 Lys Lys Lys Ile Asp 260 Tyr Asn Arg Thr 165 Ser Ile Ala Ser Ala 245 Lys Asn Pro Ala 150 Pro Glu Lys Ser Lys 230 Thr Lys Pro Leu Ile 310 Phe Asn Arg Met 215 Ile Lys Asp Ile Ala 295 Phe Lys Leu Ile 200 Glu Ile Asn Lys Glu 280 Lys Lys Glu Lys 185 Ala Val Tyr Ala Asn 265 Gin Val Glu 155 Val Asp Ala Asp Ala 235 Ile Ser Leu Lys Gly 315 INFORMATION FOR SEQ ID NO:1658: SEQUENCE CHARACTERISTICS: LENGTH: 228 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...228 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1658 Lys Arg Arg Thr Met Asp His Glu Phe Leu Ile Thr 0 0 *0 0 0 0 1 Phe Phe Thr Gly 65 Phe Leu Ile Tyr Pro 145 Leu Gly 35 Thr Tyr Gin Leu Ser 115 Leu Ile Ala Tyr Leu Leu Asp Gly 100 Ala Gly Lys Leu Phe Val Leu Val Ser Leu Lys Pro Ile Thr Thr Leu Leu Ser Leu Lys 40 Tyr Met Pro Leu Leu Ile Phe Ser Leu Asn Val Lys Val Ile Phe Ser 105 Ile Ser Leu Pro 120 Gly Glu Tyr Tyr 135 Ser Val Leu Met 150 Phe Gly Val Val Met Pro Leu Pro Phe Ser Met Lys 125 Phe Thr His Thr Ile Gly Glu 165 Met Leu Gly Gly Asp Ile 175 1203 Leu Gly Glu Thr Arg Val Ala Ser Ile Thr Ile Phe Asn Glu Ala Glu 180 185 190 Ala Leu Asn Tyr Ser Lys Ala His Gin Tyr Ala Leu Thr Leu Thr Leu 195 200 205 Ile Ser Phe Ser Leu Leu Phe Val Thr Leu Phe Leu Asn Lys Lys Gin 210 215 220 Ser Ser Phe Leu 225 INFORMATION FOR SEQ ID NO:1659: SEQUENCE CHARACTERISTICS: LENGTH: 187 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .187 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1659 Asn Phe Ile Phe Gly Glu Phe le Met Lys Arg Ser Sen Val Phe Ser 1 5 10 Phe Leu Val Ala Phe Leu Leu Val Val Gly Cys Sen His Lys Met Asp 25 Asn Lys Thn Val Ala Gly Asp Val Sen Thr Lys Ala Val Gin Thr Ala 40 Pro Val Thr Thn Giu Pro Ala Pro Glu Lys Giu Giu Pro Lys Gin Glu 55 Pro Ala Pro Val Val Giu Giu Lys Pro Ala Ile Glu Sen Gly Thr Ile 70 75- Ile Ala Ser Ile Tyr Phe Asp Phe Asp Lys Tyn Glu Ile Lys Giu Ser 90 *Asp Gin Glu Thr Leu Asp Glu Ile Val Gin Lys Ala Lys Giu Asn His 100 105 110 Met Gin Val Leu Leu Glu Gly Asn Thr Asp Giu Phe Gly Sen Sen Glu *115 120 125 Tyr Asn Gin Ala Leu Gly Vai Lys Ang Thr Leu Ser Val Lys Asn Ala *130 135 140 Leu Val Ile Lys Gly Val Glu Lys Asp Met Ile Lys Thn Ile Sen Phe 145 150 155 160 Gly Giu Sen Lys Pro Lys Cys Val Gin Lys Thr Arg Giu Cys Tyr Arg 165 170 175 Glu Asn Arg Arg Val Asp -Val Lys Leu Val Lys 180 185 INFORMATION FOR SEQ ID N0:1660: SEQUENCE CHARACTERISTICS: LENGTH: 201 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein 1204 (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .201 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1660 Lys Arg Ile Lys Arg Giy Phe Phe Met Gin Giu Ala Leu Leu Arg Phe 1 5 10 Gin Glu Gly Phe Lys Giu Trp Gly Tyr Leu Ile Leu Phe Leu Tlyr Sen 25 Leu Gly Gly Gly Tyr Val Gly Ile Val Ile Ala Ser Ile Leu Sen Ala 40 Thr Thn His Ala Leu Asp Ile Lys Ile Thr Ile Leu Val Ala Phe Leu 55 Gly Asn Leu Ile Gly Ser Gly Ala Leu Val Ile Phe Ala Ang Tyr Gin 70 75 Lys Arg Glu Phe Leu Lys Tyr Phe Gin Lys His Arg Arg Lys Leu Ala 90 Leu Ala Sen Leu Trp Val Lys Ang Tyr Ala Leu Leu Met Ile Phe Val 100 105 110 Asn Lys Tyr Leu Tyr Gly Ile Lys Ser Val Val Pro Leu Ala Ile Gly 115 120 125 Phe Ser Lys Ty-r Pro Leu Lys Lys Phe Leu Trp Leu Asn Val Phe Ser 130 135 140 Ser Phe Leu Trp Ala Leu Ile Val Gly Sen Vai Ser Phe Gin Ala Sen 145 150 155 160 Asp Trp Val Lys Thr Leu Tyr Giu Arg Leu Sen His Tyr Thr Sen Phe 165 170 175 Phe Val Ile Sen Phe Val Leu Ile Ala Leu Leu Ile Trp Phe Leu Leu 180 185 190 Lys Arg Tyr Ser Arg Lys Met Gly Phe 195 200 INFORMATION FOR SEQ ID NO:i661: SEQUENCE CHARACTERISTICS: LENGTH: 394 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Relicobacter pyloni (ix) FEATURE: NAME/KEY: misc_feature LOCATION .394 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1661 Ala Ser Phe Asn Tyr Asn Phe Gin Met Leu Arg Lys Asn Ile Leu Ala 1 5 10 is Tyr Tyr Gly Ala Asn Phe Leu Leu Ile Ile Ala Gin Ser Leu Pro His 25 Ala Ile Leu Thr Pro Leu Leu Leu Ser Lys Gly Leu Sen Leu Ser Glu 40 1205 Ile Leu Leu Val Gin Thr Phe Phe Ser Phe Cys Val Leu Vai Ala Giu Tyr Leu Phe Tyr Ile Gin 145 Leu Ile Gly Lys Leu 225 Met Phe Leu Val Phe 305 Ser Leu Thr Phe 385 Pro Val Asp Ser Lys 130 Ile Met Asp Gly 210 Val Trp Val1 Lys Leu 290 Ile Cys Ser Ile Ile 370 Leu Ser Ser Ser Ala 115 Giu Thr Leu Leu Phe 195 Ser Giy Gin Phe Ala 275 Leu Gly Leu Leu Leu 355 Ile Giy Asn Phe 100 Cys As n Lys Cys 180 Lys Leu His Ala Tyr 260 Lys Gly Val Gdy Ser 340 Ser Thr Lys Val1 Val1 Ile Ser Lys Leu Val 165 Ala Ser Lys Leu Tyr 245 Ile Asn Val Tyr Tyr 325 Ser Leu Met Ala Lou 70 Phe Leu Ser Lys Gly 150 His Leu Gin Giu Ile 230 Phe Ala Tyr Ser Ala 310 Gin Lou Ser His Lys 390 55 Ala Leu Met G ly Asp 135 Met Ala Thr Lys Leu 215 Thr Leu Phe Ser Pro 295 Lou Phe Leu Ser Phe 375 Pro Asp Ile Leu Thr 120 Leu Ile Met Ile Asn 200 Lys Pro Lys Gin Gin 280 Leu Met Ser Ser Leu 360 Ala Pho Leu Ala Leu 105 Ile Ser Ile Leu Ile 185 Leu Asp Val1 Gin Val1 265 Lys Leu Val Lys Ser 345 Giu Leu Asp Met Ser 90 Ala G iu Lys G ly Tyr 170 Ile Lys Asn Phe Giy 250 Ile Ile Leu Ala Phe 330 Cys Leu Thr Glu Ser Arg 75 Phe Ser Trp Gly Ala Ser Phe Leu 140 Ser Ser 155 Val Val Tyr Phe Leu Leu Pro Lys 220 Phe Met 235 Val Lys Ser Ile Ala Leu Ser Asn 300 Phe Phe 315 Val.Sor Val Arg Arg Tyr Lou Ile 380 Asn Val1 Tyr 110 Ile Lys Gly Ile Giu 190 Glu Lys His Gin Ile 270 Ser Pro Tyr Asn Val1 350 Sor Lou Leu Leu Gly Thr Asn Ser Phe 175 Lys Gin Ile Phe Tyr 255 His Leu Tyr Met Asn 335 Ser Pro Phe Phe Phe Leu Asp Asn Phe 160 Leu Giu Val Leu Gin 240 Leu Phe Leu Cys Ser 320 Ile Val Lou Phe 0*p* 0.0 0000* eve 0 INFORMATION FOR SEQ ID NO:i662: Wi SEQUENCE CHARACTERISTICS: LENGTH: 87 amino acids TYPE: amino acid TOPOLOGY: linear (i)MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .87 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1662 1206 Arg Arg Asn Leu Thr Arg Gin His Gly Ser Val Lys Lys Arg Glu Lys 1 5 10 Arg Phe Lys Thr His Ala Ser Leu Cys Asp Ser Val Arg Ser Gly Lys 25 Arg Leu Gly Tyr Thr Asn Gin Val Ile Thr Asp Ile Val Asn Ile Gly 40 Ile Gly Gly Ser Asp Leu Gly Ala Leu Met Val Cys Thr Ala Leu Lys 55 Arg Tyr Gly His Pro Arg Leu Glu Met His Phe Val Ser Asn Val Asp 70 75 Gly Thr Gin Ile Leu Asp Val INFORMATION FOR SEQ ID NO:1663: SEQUENCE CHARACTERISTICS: LENGTH: 74 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...74 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1663 *o*9 Gin His Tyr Pro Asn Asn Leu Lys Asp Ile Glu Met Asn Thr Glu Ile 5 10 Leu Thr Ile Met Leu Val Val Ser Val Leu Met Gly Leu Val Gly Leu 25 Ile Ala Phe Leu Trp Gly Val Lys Ser Gly Gin Phe Asp Asp Glu Lys 40 SArg Met Leu Glu Ser Val Leu Tyr Asp Ser Ala Ser Asp Leu Asn Glu 55 Ala Ile Leu Gin Glu Lys Arg Gin Lys Asn 65 9* INFORMATION FOR SEQ ID NO:1664: SEQUENCE CHARACTERISTICS: LENGTH: 242 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...242 1207 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1664 Glu Met Gin Phe Leu His Ala His Leu Leu Ser Val Val Ile Phe Phe 1 5 10 Pro Met Leu Ser Ala Leu Leu Ala Phe Phe Met Ser Asp Gin Ala Ser 25 Arg Ala Tyr Ala Ile Val Ile Ala Leu Ile Glu Leu Leu Leu Val Leu 40 Leu Leu Trp His Gly Phe Asp Ile Gin Thr Ala Gly Met Gin Phe Giu 55 Glu Met Lys Glu Leu Ala Tyr Gin Ile Gly Val Asn Tyr His Val Gly 70 75 Val Asp Gly Ile Ala Leu Phe Leu.Leu Leu Leu Asn Ala Ile Val Val 90 Leu Leu Ser Val Ile Tyr Val Lys Glu Arg Arg Lys Asp Phe Val Ile 100 105 110 Cys Leu Leu Leu Leu Glu Gly Ile Leu Met Gly Val Phe Ser Ser Leu 115 120 125 Asn Val Ile Phe Phe Tyr Ala Phe Trp Glu Ile Ser Leu Leu Pro Val 130 135 140 Leu Tyr Leu Ile Gly Arg Phe Gly Arg Asn Asn Lys Ile Tyr Ser Gly 145 150 155 160 Met Lys Phe Phe Leu Tyr Thr Phe Leu Ala Ser Leu Cys Met Leu Leu 165 170 175 Gly Ile Leu Tyr Ile Gly Tyr Asp Tyr Ala Asn Asn Tyr Gly Met Met 180 185 190 Ser Phe Asp Ile Leu Asp Trp Tyr Gin Leu Asn Phe Ser Ser Gly Ile 195 200 .205 Lys Thr Trp Leu Phe Val Ala Phe Leu Ile Gly Ile Ala Val Lys Ile 210 215 220 Pro Leu Phe Pro Phe Thr His Gly Cys Leu Met Arg Ile Leu Thr Pro 225 230 235 240 Pro Leu INFORMATION FOR SEQ ID NO:i665: SEQUENCE CHARACTERISTICS: LENGTH: 496 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein .9 (iii) HYPOTHETICAL: YES 9 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .496 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1665 Lys Ang Ser Leu Met Leu Ile Asp Ile Leu His Ile Sen Phe Asp Ser 1 5 10 Phe Sen Phe Glu Ser Ile Leu Pro Met Leu Val Leu Val Cys Gly Gly 25 Ile Phe Thn Leu Leu Ile Asn Ala Phe Thn Sen Ang Phe Sen Arg Asn 40 Leu Asn Val Phe Leu Cys Met Leu Phe Leu Val Leu Asp Phe Leu Val 55 Val Ser Gly Leu Glu Giu Gin Giu Asn Ala Phe Phe Gly Phe Leu Sen 1208 70 75 Leu Asp Thr Leu Ser Leu Ile Ser Gin Ser Ile Val Leu Ile Ser Ala 90 Phe Phe Leu Ile Phe Leu Ala Leu Ser Lys Glu Arg Phe Asn Glu Phe 100 105 110 Gin Thr Ala Glu Phe Tyr Ser Leu Tyr Leu Phe Ile Val Ala Gly Phe 115 120 125 Gln Phe Met Val Ser Ser Asn Gln Phe Val Val Ile Leu Ile Gly Leu 130 135 140 Glu Thr Ala Pro Leu Pro Leu Cys Val Leu Met Ala Leu Ser Asp Lys 145 150 155 160 Arg Tyr Gly Leu Glu Ala Gly Ile Lys Tyr Phe Thr Met Gly Ala Met 165 170 175 Ala Ser Ala Phe Phe Ala Met Gly Ala Met Ala Phe Tyr Leu Leu Thr 180 185 190 Gly Ser Leu Asn Leu Glu Val Ile Thr Leu Tyr Leu His Thr Glu Gly 195 200 205 Ile Thr Asn Pro Met Leu Phe Ala Met Gly Thr Ile Phe Leu Ile Gly 210 215 220 Ala Ile Gly Phe Lys Val Ser Leu Val Pro Phe His Thr Trp Met Pro 225 230 235 240 Asp Val Tyr Glu Gly Asn Asn Pro Val Phe Ala Ser Tyr Ile Ser Ile 245 250 255 Val Pro Lys Ile Ala Gly Phe Val Val Ala Thr Arg Leu Phe Gly Ala 260 265 270 Phe Ile Asp Thr His Thr Ala Trp Val Glu Asp Ile Phe Tyr Val Leu 275 280 285 Ile Leu Met Thr Ile Thr Ile Pro Asn Phe Ile Ala Leu Trp Gin Glu 290 295 300 Asp Val Lys Arg Met Leu Ala Tyr Ser Ser Ile Ser His Ser Gly Phe 305 310 315 320 Ala Leu Ala Cys Val Phe Ile His Thr Glu Asp Ser Gin Gin Ala Met 325 330 335 Phe Val Tyr Trp Phe Met Phe Ala Phe Thr Tyr Ile Gly Ala Phe Gly 340 345 350 Leu Leu Trp Leu Leu Lys Ser Arg Glu Lys Thr Trp Asp Glu Arg Tyr 355 360 365 Asp His Pro Tyr Ser Lys Phe Asn Gly Leu Ile Lys Thr His Pro Leu S370 375 380 Val Ala Ile Leu Gly Ala Ile Phe Val Phe Gly Leu Ala Gly Ile Pro 385 390 395 400 Pro Phe Ser Val Phe Trp Gly Lys Phe Leu Ala Val Glu Ser Ala Leu 405 410 415 Glu Ser Asn His Ile Leu Leu Ala Val Val Met Leu Val Asn Ser Ala 420 425 430 Val Ala Ala Phe Tyr Tyr Phe Arg Trp Leu Val Ala Met Phe Phe Asn 435 440 445 Lys Pro Leu Gin Thr Gin Ser Tyr Ala Gin Asn Asp Ile Tyr Thr Gin 450 455 460 Asn Ala Thr Met Pro Ile Tyr Ala Val Ile Ile Ala Met Ala Leu Ala 465 470 475 480 Cys Leu Phe Ser Val Phe Met Met Arg Gly Leu Leu Glu Phe Val Ala 485 490 495 INFORMATION FOR SEQ ID NO:1666: SEQUENCE CHARACTERISTICS: LENGTH: 296 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES 1209 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .296 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1666 Asn Pro Ala Leu Ser Leu His Thr Trp Leu Pro Tyr Ala 1 Ala Gly Ser Ile Ile Phe Ala Glu Lys 145 Asn Leu Thr Val Glu 225 Leu Glu Leu Asn Pro Thr Glu Ala Ser His Glu 130 Sen Val Leu Sen Phe 210 Asp Ile Gin Phe Arg 290 Thn Tyr Ile Gly Phe Gly 115 Arg Ala Gly dly Ile 195 Phe Leu Leu Gly Leu 275 Leu Ala Tyr Gdy Sen Asn 100 Val Ala Pro Met Phe 180 Ile Gly Asn Ile Phe 260 Gly Sen Met Phe 40 Ile Tyr His Vali Gly 120 Giu Ala Ile Tyr Val1 200 Thr Val Tyr Leu Thr 280 Phe Leu 25 Leu Ala Ala Met Ser 105 Leu Ile Phe Gly Pro 185 Tyr Gly Gly Pro Giu 265 Lys Leu Leu Ala Asp Val Val1 Leu Phe 140 Ile Gly Ala Thr Gin 220 Ser Leu Giu Glu Leu Phe Leu Leu Val Phe Ala 125 Gly Val1 Glu Ile Sen 205 Ile Val1 Leu Ile Val 285 Tyr Ser Pro Cys Lys Leu Met 110 Gly Ser Leu Phe Ile 190 Tyr Ser Ile Lys Arg 270 Ser S S *5 5 S. *S
S
S
S..
SO S
*S*S
S
S. S *5*S *5
S
INFORMATION FOR SEQ ID NO:1667: SEQUENCE CHARA CTE RISTICS: LENGTH: 468 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: 1210 *9*9 9999 9 9 9 9..
9 9* 9 9*9 999 9 9 9 99 .9.
9 9.
Ile 1 Glu Ala Lys Phe Asp Glu His Pro Ala 145 Ala Lys Ala Ser Pro 225 Asn Ala Leu Gly Gly 305 Leu Phe Leu Asn Ile 385 Glu Ile lle Lys Leu 465 NAME/KEY: misc_feature LOCATION 1...468 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1667 Tyr Ser Lys Thr Arg Ser His Asp Met Asp Ile 5 10 Tyr Asp Ile Arg Gly Ile Tyr Pro Thr Thr Leu Phe Ser Ile Gly Val Glu Leu Gly Lys Ile Met 40 Ser Val Phe Val Gly His Asp Ala Arg Val His 55 Glu Val Leu Ser Ala Gly Leu Gin Ser Ser Gly 70 75 Leu Gly Leu Ile Pro Thr Pro Val Ala Tyr Phe 90 Ile Asp Asn Ile Gin Cys Pro Asn Ser Ile Met 100 105 Asn Pro Lys Glu Tyr Asn Gly Phe Lys Ile Thr 115 120 Phe Tyr Gly Lys Asp Ile Gin Ala Leu Lys Asn 130 135 140 Lys His Glu Ile Lys Pro Leu Lys Glu Thr Pro 150 155 Leu Glu Ala Tyr His Arg Tyr Leu Ile Lys Asp 165 170 Asn Leu Lys Tyr Lys Ile Ala Leu Asp Phe Gly 180 185 Leu Gly Leu Glu Pro Ile Leu Lys Ala Leu Asn 195 200 Leu Tyr Ser Asp Pro Asp Gly Asp Phe Pro Asn 210 215 220 Ser Glu Ala Lys Asn Leu Lys Asp Leu Glu Lys 230 235 Ala Ile Leu Ile Gly Phe Ala Phe Asp Gly Asp 245 250 Met Leu Ser Ser His His Ile Tyr Ala Gly Asp 260 265 Phe Ala Lys Arg Leu His Ala Gin Gly Ile Thr 275 280 Glu Val Lys Cys Ser Gin Val Met Tyr Asn Ala 290 295 300 Lys Thr Leu Met Tyr Lys Thr Gly His Ser Asn 310 315 Lys Glu Thr Asn Ala His Phe Ala Ala Glu Met 325 330 Phe Lys Glu Arg Tyr Phe Gly Tyr Asp Asp Ala 340 345 Arg Ala Leu Glu Leu Leu Leu Glu Gin Ser Pro 355 360 Thr Ile Lys Asn Leu Pro Tyr Ser Tyr Thr Thr 370 375 380 Ala Val Ser Glu Glu Glu Lys Phe Glu Ile Ile 390 395 Ala Leu Lys Asn Pro Pro Ser His Phe Pro Thr 405 410 Ser Ile Asp Gly Val Arg Val Val Phe Glu His 420 425 Arg Ala Ser Asn Thr Thr Pro Tyr Leu Val Ser 435 440 Asp Glu Thr Thr Ala Leu Glu Tyr Lys Arg Ala 450 455 460 Glu Lys Leu Ser Asp Arg Gly Leu Ala Ile Leu 125 Thr Glu Phe Asn Ile 205 His His Ala Glu Pro 285 Ile Leu Ser Leu Ser 365 Pro Arg Ile Gly Arg 445 Phe Asn Tyr Phe Val Phe Gly Gin Leu Val His 175 Val Phe Pro Arg Arg 255 Ala Val Thr Ile His 335 Ala Leu Glu Leu Glu 415 Gly Glu Arg Thr Asp Leu Tyr Asn Ser Asn Asn Asn 160 Leu Gly Ser Asp Glu 240 Ile Ile Ile Phe Lys 320 Ile Cys Glu Lys Gln 400 Ile Leu Gly Leu Leu Gly Leu
C
1211 INFORMATION FOR SEQ ID NO:1668: SEQUENCE CHARACTERISTICS: LENGTH: 214 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .214 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1668 Gly 1 Val Thr Asn Cys Thr Ala Ala Asn Ser 145 Tyr Giu Thr Thr Ile Phe Met Asn Giu Ile Ile Leu p.
p Gly Leu Val1 Ala Leu Tyr Gly 130 Val Lys Giu Ala Ala 210 Gin Leu Gin Gly Met Asp Pro 115 Ser Met Thr Lys Lys 195 Glu Asn Thr Ala Arg Val Leu 100 Lys Leu Lys Leu Ile 180 Leu G lu 5 Thr Pro Tyr Val1 Glu Gly Tyr Giu Tyr Vai 165 Ala Lys Ser Ala Lys Leu Gly Asn Val1 Ala Pro Cys 150 Pro His Asn Ile Leu Lys Lys Gly Leu Lys Pro Thr 135 Glu Cys Met Glu Tyr Ser 40 Giu Ile Leu Lys Asn 120 Asn Tyr Asn Ile Lys 200 Gly Asn Leu Thr Met Tyr Leu Giu .Ala 140 Glu Glu Ile Met Ala Lys Leu Gly Asn Leu Ala Sen 125 Leu Lys Phe Ala Trp 205 Tyr Pro Asp Ile Asp Phe Ser 110 Asp Ala Gly Asp Arg 190 Gly Gly Asp Lys Ile Leu Sen Ser Leu Lys Val Lys 175 Met Asp
INFORMATION
FOR SEQ ID NO:1669: i) (vi) SEQUENCE CHARACTERISTICS: LENGTH: 405 amino acids TYPE: amino acid TOPOLOGY: linear MOLECULE TYPE: protein HYPOTHETICAL: YES ORIGINAL SOURCE: ORGANISM: Helicobacter pyl~ori 1212 (ix) FEATURE: (xi) His NAME/KEY: miscfeature LOCATION .405 SEQUENCE DESCRIPTION: SEQ ID NO:1669 Ala Asn Arg Thr Ile Ile His Arg Ile Asp Asp Ser Ile Ala Ala 1 Gin Ala Lys Asp Ser Leu Gin Leu Ala 145 Trp Phe Phe Val Vai 225 His Phe Glu Glu Lys 305 Lys Ala Val Lys Ser 385 Ile Arg Pro Ile Ser Val Lys Asn Gin 130 Leu Asp Val Trp Leu 210 Gin Asp Asp Ala C Ile 290 Glu Arg Leu Phe Leu 370 Ser Ile Val Leu Leu Glu Leu Thr Tyr 115 Val Leu ly Gly Leu 195 lu LYs Lys Ile Glu 275 kla Phe lie Ile :ys 355 GIn Ile *ys Asp Tyr Ala Thr Glu Tyr 100 Thr Gin Gin Ser Asp 180 Leu Ile His Lys Va1 260 Ser Phe Tyr Ala Ala 340 Asn Arg Pro Lys 5 Asn Leu Leu Ser Asn Asp Thr His Asp Gly 165 Leu Gly Ala Phe Ile 245 Ala Gly Tyr Gin Lys 325 Pro Gln Glu Val Gly 405 Ala Thr Gly Va1 70 Glu Phe Thr His Pro 150 Ala Glu Gly Leu Lys 230 Gin Phe Gin Pro Ala 310 Lys Phe Leu Tyr Gly 390 Arg Ser Gly Pro 75 Glu Leu Asp Leu Pro 155 Ile Va1 Lys Asn Gly 235 Asn Va1 Leu Asn Leu 315 Leu Val Leu His Ala 395 Vai Asn Phe Cys Leu Cys Asn 125 Ser Ile Gly Arg Pro 205 Leu Phe Ile Thr Leu 285 Val Val Glu Cys Lys 365 Pro Phe Arg Ala Ser Gly Asn Asp 110 Thr Val Gly Ala Phe 190 Arg Leu Lys Gly Ile 270 Gin Val Leu Ile Ser 350 Arg Pro Asa Gly Phe Pro Lys Leu Leu Asp Leu Phe Phe Glu His Pro Leu Leu Asp Ile Val 160 Glu Cys 175 Glu Glu Arg Leu Lys Arg Gin Met 240 Arg Leu 255 Ser Phe Ser Asp Arg Leu Glu Pro 320 Ile Thr 335 Gly Gly Leu Lys Asn Asp Pro Thr 400 *0 00*0
S.
5 Ib. S INFORMATION FOR SEQ ID NO:1670: i) SEQUENCE CHARACTERISTICS: LENGTH: 446 amino acids 1213 TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...446 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1670 o 'e.
Arg 1 Leu Pro Ile Gly Arg Leu Asp Tyr Ile Ser Gly Leu Tyr Thr Phe Leu 130 Leu Leu 145 His Leu Pro Glu Ser Ser Val Arg 210 Thr Ile 225 Met Gly Glu Asp Pro Trp Ser Thr 290 Asp Phe 305 Met Thr Phe Ile Ala Trp Leu Phe 370 Gly Leu Arg Phe Ala Val Tyr 115 Gly Met Gly Asn Leu 195 Phe Gly Leu Pro Ile 275 Ala Tyr Ile Ser Ala 355 Trp Ala Ser Ile Glu Phe Ser 100 Ala Arg Met Gly Leu 180 Ala Met Ile Leu Glu 260 Thr Ser Ala Ser Thr 340 Gly Ser 5 Leu Leu Tyr Thr Val Gly Leu Tyr Ser Ile 165 Ser Trp Ser Ser Gly 245 Lys Gly Ser Thr Arg 325 Asp Phe Arg Tyr Gly Thr Arg 70 Ile Ala Ser Lys Ala 150 Gly Phe Gly Ile Trp 230 Val Ile Ile Gin Ile 310 Leu Lys Gly Met Val Ala Ser 55 Phe Leu Lys Ile Ala 135 Leu Glu Leu Leu Arg 215 Met Ala Phe Leu Leu 295 Phe Ser Asn Ala Thr Gly Leu 40 Val Ser Ile Leu Gly 120 Val Ile Gly Gin Gly 200 Ser Val Tyr Ile Leu 280 Leu Asn Val Ala Ser 360 Arg Gly 25 Ile Ile Asp Leu Phe 105 Thr Cys Val Ile Gly 185 Tyr Ile Ile Val Val 265 Ser Val Lys Leu Ser 345 Phe Ile 10 Leu Asn Ala Asp Lys 90 Glu Leu Trp Val Lys 170 Ser Phe Arg Ser His 250 Met Ala Ser Asn Gly 330 Ile Gly Gly Asn Val Ser His Phe Thr Ile Asp 140 Ile Ile Val Gin Val 220 Ile Phe Gin Leu Ser 300 Pro Ala Ser Val Ile 380 Ser Phe Ile Ile Tyr Phe Val 125 Leu Val Lys Val Pro 205 Pro Gly Asp Leu Ala 285 Thr Gin Cys Ile Ile 365 Ala His Val Thr Leu Phe Gly 110 Ser Ile Met Glu Ala 190 His Lys Ala Leu Leu 270 Ala Ile Lys Ile Val 350 Leu Gly Ile Ala Ile Arg Ser Ile Tyr Gin Ile Ile 175 Ile Ile Ala Cys Ser 255 Phe Val Ala Leu Ala 335 Ser Phe Met Phe Glu Cys Gly Ala Ser Asp Met Ser Gly Trp Leu Leu Met Gly Ala Lys Ser Leu Ser Gin Thr Gly Ile 160 Lys Ile Leu Thr Val 240 Leu Asn Met Glu Val 320 Phe Tyr Ser Leu
S
S. S 5 375 Ser Gly Ala Ser Thr Val Ile Leu Tyr Asp Lys Phe Gly Lys Ser Phe 385 Leu Ile Ala 1214 390 395 400 Asp Ile Tyr Glu Ile Val Pro Gly Phe Ile Val Ala Ser Val Ala 405 410 415 Val Ala Phe Ser Leu Phe Ser Ser Val Arg Ser Gly Thr Lys Glu 420 425 430 Phe Glu Thr Met Leu Lys Glu Ile Glu Ser Leu Lys His 435 440 445 INFORMATION FOR SEQ ID NO:1671: SEQUENCE CHARACTERISTICS: LENGTH: 375 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...375 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1671 c cc Asn 1 Ile Asn Gin Ser Leu Phe Phe Lys Asn 145 Ala Ile Val Val Asn 225 Thr Ile Lys Trp Ile Lys Gly Ala Val Val Phe Val Thr Asn Asp Lys Lys Thr Ser Gin 130 Pro Thr Pro Ile Leu 210 Lys Pro Lys Thr Gin Tyr Asp Ala Ser Pro 115 Ser Asn Asn Ala Ala 195 Ile Met His Gly Phe Pro Thr Ala Leu Pro 100 Lys Pro Gly Glu Phe 180 Gin Pro Gly Gly Tyr 5 Ser Ser Phe Thr Asn Pro Gin Lys Ile Asn 165 Leu Val Lys Glu Ile 245 Asn Leu Ile Leu Leu Thr Gin 55 Ile Lys 70 Ser Lys Met Asp Leu Asp Asn Tyr 135 Asp Ser 150 Lys Leu Ile Thr Glu Ser Gly Ser 215 Tyr Arg 230 Asn Ile Gly Leu Tyr Asn 40 Asn Ala Glu Pro Leu 120 Glu Phe Leu Pro Asp 200 Lys Leu Met Val His 25 Asp Pro Leu Met Lys 105 Leu Glu Thr Arg Ile 185 Ile Val Asp Leu Gly 265 10 Gin Asp Gin Gin Asn 90 Thr Ala Asn Asn Thr 170 Ser Phe Ile Ile Thr 250 Glu Lys Glu Pro Glu 75 Tyr Thr Ser Leu Leu 155 Ile Ser Ala Gly Val 235 Asn Leu Gly Pro Val Thr Gin Ser Pro Arg Ile 140 Lys Thr Gin Ser Tyr 220 Trp SAla Ile Gly Lys Lys Asn Leu Lys Pro Ile 125 Phe Glu Ala Ile Met 205 Tyr Ser Lys Glu Phe Ala Tyr Thr Lys Glu Lys 110 Thr Pro Lys Asp Ala 190 Gly Ser Arg Gly Arg 270 Ala Pro Pro Glu Ala Glu Lys Pro Val Asp Lys 175 Gly Lys Asn Ile Ala 255 Asn Thr Leu Leu Ser Ala Thr Asp Phe Asp Ile 160 Met Lys Ala Asn Ile 240 Asp Phe 260 Gin Arg Tyr 275 Gly Val Pro Leu Leu Leu Ser Thr Leu Thr Asn Gly Leu Ser Gly 310 Asn Ile Asp Leu 1215 Leu Asri Asn Arg Gly 300 Tyr Leu Leu Leu Gin 315 Val Val Asn Gin Ile 330 Val Ile Arg Giu Gly 345 Phe Phe Pro Ile Pro 360 Lys Giu Giu Met Ar; Gin 320 Ar; Asp Lys 335 Ar; Val Phe 350 Giu Asn Giu INFORMATION FOR SEQ ID NO:i672: SEQUENCE CHARACTERISTICS: LENGTH: 121 amino acids TYPE: amino acid TOPOLOGY: iinear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .121 (xi) SEQUENCE DESCRIPTION: SEQ ID N0:1672 1Lys Ala Ala Phe Leu Ala Giy Ser 65 Leu Val Phe Asp Leu Ile Gly Asn Gly Glu Phe Val Gin Phe Gly Ser 115 Phe 20 Met Phe Ang Ile Ile 100 Val Cys Leu Gin Leu Thr Vai Trp Arg Ile Gly Ile Lys Giu Thr Giy Met 55 Lys Ser 70 Ile Leu Val Thr Gly Asn Ile Leu Lys 40 Thr Sen Leu Tyr Leu 120 Phe 25 Ar; Leu Phe Pro Pro 105 Leu Phe Tyr Giy Leu Gin Pro Ala Met.Asn Leu Cys Ala Ile Ile Thr 75 Ile Leu Ser 90 Ile Ala Gin Ala Ser Ile Vai Ile His Phe Giu Tyr Phe Ser Phe Leu 110 Tyr Gin Tyr Phe His Ala Phe Asp Val1 Gin Thr Giy Val INFORMATION FOR SEQ ID NO:1673: SEQUENCE CHARACTERISTICS: LENGTH: 130 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori 1216 (ix) FEATURE: NAME/KEY: misc-feature LOCATION .130 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1673 Met Leu Lys Lys Lys Ile Asp Leu His Lys Asp Ser Ile Arg Lys Leu 1 5 10 Phe Phe Tyr Tyr Phe Ile Pro Leu Val Phe Ser Met Ile Ser Leu Ser 2S Thr Tyr Ser Met Val Asp Asp Met Phe Val Gly Lys Lys Leu Gly Lys 40 Giu Ala Ile Ala Ala Val Asn Ile Ala Trp Pro Ile Phe Pro Gly Leu 55 Ile Ala Tyr Glu Leu Leu Phe Gly Phe Gly Ala Ala Ser Ile Val Gly 70 75 Tyr Phe Leu Gly Gin Asn Lys Thr His Arg Ala Arg Leu Val Phe Ser 90 Ser Val Phe Tyr Phe Val Ala Leu Ser Ala Phe Ile Leu Ser Met Ala 100 105 110 Leu Leu Pro Phe Ser Glu Asn Ile Ala Arg Phe Leu Gly Ala Met Thr 115 120 125 Leu Tyr 130 IFORMATION FOR SEQ ID NO:i674: SEQUENCE CHARACTERISTICS: LENGTH: 161 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION .161 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1674 Asn His Phe Asn Gly Cys Val Phe Arg Val Gin His Leu Leu Ala Asp 1 5 10 Val Phe Val Val Asn Asp Lys Arg Pro Val Leu Ala Met Val Ala Met 25 Leu Ile Gly Ser Leu Ala Asn Ile Phe Phe Asn Tyr Leu Phe Ile Phe 40 Val Leu Giu Val Gly Val Gin Gly Sen Ala Ile Ala Thn Val Ile Gly 55 His Ala Ile Gly Val Leu Val Leu Met Gin His Phe Tnp Arg Lys Lys 70 75 Gly Gin Leu Tyr Phe Ile Lys Arg Phe Ser Leu Ser Sen Val Ile Sen 90 Ser Ala Lys Ser Gly Val Pro Gin Sen Thr Ala Giu Phe Ser Ala Ser .100 -105 110 Ile Met Ile Leu Leu Phe Asn Thr Ala Ile Met His Thr Ala Gly Giu 115 120 125 Ang Phe Val Ser Met.Tyr Gly Ile Val Met Tyr Asn Ala Ile Ile Phe 130 135 140 1217 Phe Thr Thr Leu Phe Ala Ile Ser Gin Gly Ile Gin Pro Ile Ala Glu 145 150 155 160 Leu INFORMATION FOR SEQ ID NO:1675: SEQUENCE CHARACTERISTICS: LENGTH: 426 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...426 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1675 4 4 *4 4 Phe 1 Val Asn Gin Ile Tyr Gly Ile Ile Leu 145 Val Met Val Pro Phe 225 Asp Gly Leu Val Lys Val 50 Leu Glu Asp Ile Met 130 Gly Ala Ser Ala Tyr 210 Ala Val Ala Gly Arg 35 Ala Gin Gly Gin Ile 115 Pro Thr His Asp Gly 195 Leu Lys Ser Ser Met Ala Leu Gly Val Gly 100 Phe Leu Ser Thr Ser 180 Pro Ile Ile Ala Thr 260 5 Ala Ile Gly Leu Arg Ile Phe Val Lys Glu 165 Glu Val Ala Ile Glu 245 Gly Gly Leu Val Asn Ala Ala 70 Phe Gly Ala Ile Ala 150 Ala Ile Leu Ala Tyr 230 Glu Leu Met Gly Leu Tyr Leu 55 Ser Leu Gly Ser Asn 135 Glu Pro Phe Ala Ser 215 Pro His His Leu SMet Phe Arg 40 Ala Gly Phe Phe Leu 120 Leu Ser Leu Ala Gly 200 Phe Gin Val Leu Ala 280 Glu Leu 25 Thr Leu Ile Gly Ile 105 lle Ile Met Val Val 185 Tyr Met Asn Asn Ala 265 Leu His Asn Ile Arg Asp Leu Thr Met Ile Phe 10 Ile Ile Tyr Gin Asn 90 Phe Ser Gly Ser Ile 170 Met Ala Ser Glu Ile 250 Leu Val Leu Ala Val Val Ser 75 Leu Ala Leu Gly Ala 155 Lys Cys Ser Ala Thr 235 Ile His Asn Ser Ser Trp Ser Pro Val Ala Ile Leu Ala 140 Ala Pro Val Met Pro 220 Ile Glu Val Gly Leu Ser Val Ala Leu Ile Pro Asn Tyr 125 Leu Ala Tyr Gly Gly 205 Gly Ser Ala Gly Leu 285 Gly Leu Phe Phe Gly Gly Asn Val 110 Tyr Gin Asn Leu Met 190 Ile Gly Ser Ile Ala 270 Leu Val Phe Ser Val Arg Tyr Ala Leu Leu Lys Ile Lys 175 Ala Pro Leu His SAla 255 Met SGly Val Ser Gly Ile Glu Gly Lys Ala Lys Cys Phe 160 Ser Ser Leu Leu Ala 240 Asn Leu Val Leu Leu Ala Phe Val 275 Val Gly Gly Phe 290 295 300 Gly Thr Leu Leu Lys.Pro Leu Ala Phe Met Leu Gly Val Pro Trp Ser 1218 305 Gin G lu Pro Cys Giy 385 Lys Ala Ala Phe Leu Gly 370 Ser Ala Gly Ile G ly 340 Leu Aia Val Leu Phe 420 Ala 325 Ser Asn Pro Val1 405 Ile 310 Gly Met Giu Leu Lys 390 dly Gly Glu Gin Lys Ser 375 Lys Thr Leu Ile Leu Thr 360 Ser Lys Leu Ser Ilie Leu 345 Lys Val Asp Ser Ala 425 315 Gly Ile 330 Pro Tyr Ala Ile Ala Met Phe Ile 395 Asn Phe 410 Asn Ile Ala Gly Asp 350 Thr Phe 365 Ile Giy Arg Leu Ser Ala Leu 335 Asn Ala G ly Ala Thr 415 a INFORMATION FOR SEQ ID NO:1676: SEQUENCE CHARACTERISTICS: LENGTH: 316 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 316 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i676 Thr Leu Sen Lys Giu Giu Gly Leu Met Pro Gin Asn Gin Leu Val Ile a S a a
I
Thr Leu Gly Met 65 Gin Leu Ile Leu Pro 145 Giu Asp Ile Ile Lys Leu Thr Lys Phe Lys Giu 130 Asn Arg Phe Val Ile Arg Gly Ser Asn Ile Lys 115 Asn Gly Asn Ile Asp 195 Asp Asn Val1 Glu Val 100 Gly Leu Met His Aia 180 Phe 5 Giu Leu Gly Arg Ala Gly Ala Ser Pro Pro 165 Pro Val Ser Ile Phe Asn 70 Leu Gin Asn Leu Leu iso Ilie Leu Lys Gly Ile Leu 55 Ala Ala Lys Gly Asn 135 Lys Lys Asn Thr Ser Sen 40 Lys Val Lys Ile Gly 120 Gin Thr Lys Thr Arg Lys 25 Val1 Phe Leu Glu Ang 105 Gly Lys Tyr Ile Pro 185 Ser 10 Gin Val1 Leu Arg Ile 90 Gly His His Sen Lys 170 Val Asn Leu Ile Ile Asp 75 Lys Leu Leu Leu Ala 155 Gly Ala Lys Leu Ala Phe Asn Giu Tyr Ala 140 Ile Val1 Ala Gly Phe Leu Lys Ang Lys Sen Asp 125 Leu Lys Giu Ser Tyr 205 Ser Leu Met Gly Arg Leu 110 G iu Met Pro Ser Ala 190 Gly Lys Ile Asp Leu Giu Ile Val1 Leu Thr Gly 175 Asp Asn As n Val1 Thr Tyr Giu Glu Asp Ile Lys 160 Ile Gly Leu Val Arg 210 Ile Giu His Ala Phe Gly Phe Sen Ser Ile Tyr Thr His Leu Asp 225 Ile Tyr Ala Ile Gin 305 As n Ser Arg 260 Leu Lys Val Val1 Gly 245 Phe Asp Asn Asp 1219 Ile Gin 235 Gly Gly Asp Ala Leu Giu Giu Asp 300 Gly Gin 315 Lys Gly Gin Leu 240 Giu Lys Leu His 255 Giu Lys Phe Leu 270 Glu Asn Lys Phe 285 Ile Val Gin Leu INFORMATION FOR SEQ ID NO:1677: SEQUENCE CHARACTERISTICS: LENGTH: 315 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAMAEIKEY: misc-feature LOCATION I1.. .315 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1677 1Gly Phe Leu Val Phe Leu Asp Arg Arg Leu Ile Val
S
9. 5 *SSe 5* *5 *5*S S 59
S
Se Ser Va 1 His Lys Gly Giu Gly Asp 145 Ang Leu Val1 Lys Lys 225 Lys Leu Sen Ala Leu Giu Glu Ile 130 Met Ser Gly Val 210 Ile Gly Tyn 35 Leu Leu Ser Arg Giu 115 Thr Pro His Thr Leu 195 Phe Val Ser 20 Ala Leu Ile Leu Ile 100 Lys Gly Leu Pro Ala 180 Ala His Val 5 Arg Leu Val1 Thn Gin Asn Glu Leu Glu Ile 165 Ile Ser Pro Lys Ler Leu Lys 70 Met Asp Glu Gin Sen 150 Leu Asn Lys Phe Thr Ile Sen Asn 55 Glu Asp Leu Gly Lys 135 Tyr His Thr G ly dly 215 Gly Asn Val 40 Lys Phe Giu Giu Asn 120 Sen Ang Val Pro Trp 200 Phe Glu Val- His 25 Val Gly Giu Ile Giu Lys Phe Leu 90 Glu Val 105 Phe Ser Phe Ile Arg Val Leu His 170 Val Tyr 185 Asn Gly Lys Thr Phe Val Ile Leu Sen Leu Lys Asn Lys Arg 75 Asp Asp Val Gly Sen Arg Met Ang 140 Sen Ala 155 Asn His Ala Sen Gly Tyr TyrnTyr 220 Lys Lys 235 Met Phe Leu Ile Glu Leu Val Leu 125 Leu A Thr Ala Gly 205 Ala Cly Val1 Ang Phe Giu Thn Gin Asn 110 Asp Ile Phe Gly Sen 190 Asn His Gin Thr Gin Leu Lys Asn Leu Arg Val Pro Asn Leu 175 G ly Leu Leu Leu Asp Ile G ly Gin Glu Sen Pro Ala Asn Lys 160 Asp Val Ile Asn Ile 240 230 Gly Tyr Sen Gly Asn Thn Gly Met Ser Thr Gly Pro His Leu His Tyr 1.220 Giu 'rrp Arg Asp 305 245 250 255 Arg Phe Leu Asp Gin Pro Ile Asn Pro Met Ser Phe Thr Lys 260 265 270 Met Lys Asp Phe Giu Giu Val Phe Asn Lys Giu Arg Ser Ile 275 280 285 Gin Ser Leu Ile Thr Ile Ile Asn Arg Leu Met Gin Lys Gin 295 300 Arg Leu Ser Ser Leu Lys Ala Pro Lys 31.0 32.5 INFORMATION FOR SEQ ID NO:i678: SEQUENCE CHARACTERISTICS: LENGTH: 460 amino acids TYPE: amino acid TOPOLOGY: iinear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyiori (ix) FEATURE: NAME/KEY: misc-feature LOCATION i. .460 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1678 *44* 4* 4 4 4* 4 .4 4 1Asp Ile Giu Phe Ala Asn Leu Tyr His Ile Pro Gin Ser Leu Arg Ile Leu Pro His Ser 2.45 Asn Thr Arg Giu Aia 225 Leu Ala 3er 3iY Pro 50 Leu Pro Pro Leu Lys 130 Ser Gin Tyr Phe Pro 210
LYS
LYS
Pro Pro Giu 35 Tyr Gin Met Vai Lys 115 As p Trp Ala Ile Phe 195 Phe Met Lys Pro Gin Trp Phe Asn Ile Thr 100 Lys Ala Phe Giy 180 Thr Lys Ser Tyr Ala 260 Ser Asp Trp His 85 Leu His Leu Phe Asp 165 Giy Lys Gin Lys Giy 245 Lys Leu Asp Lys Giy 70 Cys Pro Ala Vai Leu 150 Gin Ile Aia Leu Ser 230 Ala Pro Leu Giu 55 Vai Lys Giu Ser Giu 135 Arg Asn Giu Leu Ile 22.5 Lys Asp His Ser 40 Asn Ser His Asp Trp 2.20 Thr Tyr Tyr His Arg 200 Thr Giy Ala rhr 25 Ser Leu Arg Cys Ile 2.05 Arg Asp Thr Leu Aia 185 Asp Gin Asn Val 2.0 Lys Ser Giy Gin G iy 90 Vai1 Phe Thr Thr Lys 170 Ile Leu Gly Val.
Arg 250 Giu Leu Lys.
Arg 75 Ile Ile Ala Met Pro 2.55 Tyr Leu Giy Met Val 235 Leu Ile Giu Aia Arg Tyr Val2 Asp Gin Asp 140 Lys Phe His Tyr Val 220C Ser PhE Lys Ile Arg Vai Trp 4 Pro Gly Cys 2.25 Thr Asn Met Leu Leu 205 Leu Pro Ile lai eu Lys Ile Gl Giu Giu 110 Pro Phe Gin Pro Leu 190 His Lys Lys Leu Ile is Lys Lys Asn Aia Thr Giy Arg Ile Arg Vai 2.75 Tyr Leu Asp Giu Phe Thr Asn Ile Tyr Pro Gin Asn Cys Gin Giu 160 Asp Ala Asp pGiy Ile 240 Aia Glu Leu Giu Trp Asn 265 Asp Asn Ala 255 Leu Giu Giy 270 1221 Ala His Arg Phe Ile Lys Arg Leu Tyr Asp Lys Ala Asn Ala Ile Thr 275 280 285 Pro Thr Thr Ser Lys Pro Giu Phe Lys Giu Val Gly Leu Asri Giu Ala 290 295 300 Gin Lys Leu Ala Arg Lys Lys Val Tyr Giu Ala Leu Lys Lys Ser His 305 310 315 320 Giu Ile Phe Asn Lys Ala Giu Ser Ala Tyr Ala Phe Asn Thr Leu Ile 325 330 335 Ala Ser Cys Met Giu Ala Leu Asn Ala Leu Asn Ala Gin Ser Asp Giu 340 345 350 Gin Ilie Leu Cys Giu Giy Tyr Phe Val Leu Leu Gin Ile Leu Giu Pro 355 360 365 Met Ile Pro His Thr Ala Trp Giu Leu Ser Giu Arg Leu Phe Lys Arg 370 375 380 Giu Asn Phe Lys Pro Ile Giu Val Asp Giu Ser Ala Leu Ile Giu Asp 385 390 395 400 Phe Met Thr Leu Gly Leu Thr Ile Asn Gly Lys Arg Arg Ala Giu Leu 405 410 415 Lys Val Asn Ile Asn Ala Ser Lys Glu Glu Ile Ile Ile Leu Ala Lys 420 425 430 Lys Giu Leu Giu Lys Tyr Leu Giu Asn Ala Ser Val Lys Lys Glu Ile 435 440 445 Tyr Val Pro Asn Lys Leu Val Asn Phe Val Thr Ala 450 455 460 .000 INFORMATION FOR SEQ ID NO:1679: SEQUENCE CHARACTERISTICS: LENGTH: 403 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori.
(ix) FEATURE: NAME/KEY: misc-feature LOCATION .403 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1679 Leu Asn Leu Trp Leu Lys Sen Leu Met Ang Gly Asn Sen Ile Met Lys 1 5 10 is Asn Ser His Gly Leu Lys Ala Phe Leu Giu Thr Lys Pro Lys Glu Tyr 25 His Lys Phe Asp Pro Sen Arg Phe Ile Gin Ile Tyr Lys Asp Phe Lys 40 Asn Ala Phe Phe Glu Ile Gi7n Ala Lys Val Ile His Val Val Gly Thr 55 Asn Gly Lys Gly Sen Thn Gly Arg Phe Leu Thn Leu Leu Leu Ala Asp 70 75 Gin Gly Phe Lys Val Leu His Phe Thn Ser Pro His Val Phe Glu Phe 90 Arg Glu Arg Phe Tyr Leu Asn Gly Sen Val Val Lys Glu Ser Val Leu 100 105 110 Glu Asn Ala His Gin Gin Leu Gin Sen His Ala Phe Sen Asn Ala Cys 115 120 125 Ser Tyn Phe Giu Tyn Ala Thn Leu Leu Ala Val Met Leu Ala Lys Asp 130 135 140 Cys Asp Tyr Leu Val Leu Giu Ala Gly Leu Gly Gly Giu Phe Asp Ser 1222 145 150 155 160 Thr Asn Ala Leu Glu Lys Thr Leu Ser Val Phe Thr Pro Ile Asp Tyr 165 170 175 Asp His Lys Glu Phe Leu Gly Asp Ser Leu Glu Ser Ile Ala Thr Thr 180 185 190 Lys Leu Lys Ala Met Gly Ser Leu Asn Ile Ile Ala Pro Gin Gin Glu 195 200 205 Leu Val Leu Asn Val Ala Gin Lys Ile Ala Lys Asp Lys His Ala Gin 210 215 220 Leu Ile Val Val Gin Asn Glu Ile Ser Lys Gly Val Ser Asp Tyr Ile 225 230 235 240 Glu Arg His His Leu Ala His Phe Leu Ala Met Asn Leu Glu Val Ala 245 250 255 Leu Lys Ala Phe Glu Thr Leu Leu Pro Cys Asn Lys Gin Glu Val Leu 260 265 270 Lys Asn Leu Lys Pro Leu Asp Leu Ile Gly Arg Cys Glu Leu Leu Ser 275 280 285 Pro Asn Ile Leu Ile Asp Val Gly His Asn Pro His Ser Ala Lys Ala 290 295 300 Leu Lys Glu Glu Ile Lys Arg Ile Phe Asn Ala Pro Ile Val Leu Ile 305 310 315 320 Tyr Asn Cys Tyr Gin Asp Lys Asp Ala Phe Leu Val Leu Glu Ile Leu 325 330 335 Lys Ser Val Val Lys Lys Val Leu Ile Leu Glu Leu His Asn Glu Arg 340 345 350 Ile Ile Gin Leu Glu Lys Leu Lys Gly Ile Leu Glu Thr Leu Gly Leu 355 360 365 Glu His Ala Leu Phe Glu Glu Leu Lys Glu Asn Glu Asn Tyr Leu Val 370 375 380 Tyr Gly Ser Phe Leu Val Ala Asn Ala Phe Tyr Glu Arg Tyr Pro Lys 385 390 395 400 Lys Arg Asp INFORMATION FOR SEQ ID NO:1680: SEQUENCE CHARACTERISTICS: LENGTH: 227 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: 0 ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .227 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1680 Ser Val Ser Ser His Ser Gly Ser Ala Asp Leu Leu Glu Asn Leu Gly 1 5 10 Val Asn Ile Glu Met Asn Pro Met Gin Leu Glu Asn Cys Phe Lys Gin 25 Ser His Phe Gly Phe Leu Phe Ala Pro Leu Tyr His Gin Ser Phe Lys 40 Lys Ser Ala Pro Leu Arg Lys Glu Leu Phe Thr Lys Thr Ile Phe Asn 55 Cys Leu Gly Pro Leu Ile Asn Pro Leu Arg Pro Lys Ile Gin Leu Leu 70 75 1223 Gly Val Tyr Asp Lys Ser Leu Cys Lys Thr Met Ala Leu Ala Leu Lys 90 Ala Leu Gly Val Lys Arg Ala Met Val Val Asn Gly Gly Gly Thr Asp 100 los 110 Glu Ile Val Leu His Asp Ile Thr His Ala Cys Glu Leu Lys Asn Asn 115 120 125 Glu Ile Leu Glu Tyr Asp Leu Ser Ala Lys Asp Phe Asp Leu Pro Pro 130 135 140 Tyr Asp Leu Lys Glu Leu Gin Ile Giu Asn Ala Lys Giu Ser Val Gin 145 150 155 160 Ala Cys Leu Asp Ile Leu Glu Asn Lys Gly Lys Asp Ser His Thr Met 165 170 175 Val Val Ala Ala Asn Val Ala Ser Leu Leu Tyr Leu Ser His Arg Ala 180 185 190 Lys Gly Phe Lys Arg Gly Arg Glu His Asp Phe Arg Ala Phe Lys Asn 195 200 205 Gin Ser Ala Leu Cys Ala Phe Thr Lys Asn His Lys Ala Lys Pro Cys 210 215 220 Leu Ala Cys 225 INFORMATION FOR SEQ ID NO:1681: SEQUENCE CHARACTERISTICS: LENGTH: 294 amino acids TYPE: amino acid TOPOLOGY: linear MOLECULE TYPE: protein 9 (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylorn (ix) FEATURE: NAME/KEY: misc-feature 99 LOCATION .294 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1681 Asn Leu Val Val Ser Val Pro Ala Thr Ser Ala Asn Leu Gly Pro Gly 1 5 10 Phe Asp Cys Leu Gly Leu Ser Leu Asn Leu Arg Asn Arg Phe Phe Ile 25 Giu Pro Ser Asn Ile His Ala Val Lys Leu Val Gly Giu Gly Glu Gly :35 40 Ile Pro Lys Phe Leu Thr Asn Asn Ile Phe Thr Lys Val Phe Tyr Giu 55 Ile Leu Lys Lys His Gly Asn Asp dly Sen Phe Lys Phe Leu Leu His 70 75 Asn Lys Vai Pro Ile Thr 1Krg Gly Met Gly Ser Ser Sen Ala Met Ile 90 Val Gly Ala Val Ala Ser Ala Phe Ala Phe Leu Gly Phe Ala Phe Asp 100 105 110 Arg Glu Asn Ile Leu Asn. Thr Ala Leu Ile Ty'r Glu Asn His Pro Asp 115 120 125 Asn Ile Thr Pro Ala Val Phe Gly Gly Tyr Asn Ala Ala Phe Val Giu 130 135 140 Lys Lys Lys Val Ile Ser Leu Lys Thr Lys Ile Pro Ser Phe Leu Lys, 145 150 155 160 Ala Val Met Val Ile Pro Asn Arg Val Ile Sen Thr Lys Gin Ser Ang 165 170 175 His Leu Leu Pro Lys .Arg Tyr Ser Vai Gin Giu Sen Val Phe Asn Leu 1224 180 185 190 Ser His Ala Ser Leu Met Thr Met Ala Ile Val Gin Gly Lys Trp Asp 195 200 205 Leu Leu Arg Cys Cys Ser Lys Asp Arg Met His Gin Tyr Lys Arg Met 210 215 220 Gin Thr Tyr Pro Val Leu Phe Ala Ile Gin Lys Leu Ala Leu Glu Asn 225 230 235 240 Asn Ala Leu Met Ser Thr Leu Ser Gly Ser Gly Ser Ser Phe Phe Asn 245 250 255 Met Cys Tyr Glu Glu Asp Ala Pro Lys Leu Lys Gin Val Leu Ser Lys 260 265 270 Lys Phe Pro Lys Phe Arg Val Ala Val Leu Asp Phe Asp Asn Asp Gly 275 280 285 Val Leu Ile Glu Lys Asp 290 INFORMATION FOR SEQ ID NO:1682: SEQUENCE CHARACTERISTICS: LENGTH: 298 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein S(iii) HYPOTHETICAL: YES S, (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori o (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...298 M (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1682 Leu Val Phe Lys Lys Pro Phe Phe Lys Asn Arg Leu Leu Asn Val Thr 1 5 10 Asn Lys Leu Lys Phe Val Lys Ile Thr Ile Met Ile Lys Asp Phe Asn 25 His Tyr Cys Arg Lys Ile Thr Arg Gly Phe Val Lys Ile Pro Thr Lys 35 40 Lys Gin Gly Ala Lys Lys Met Lys Lys Ala Gly Phe Leu Phe Leu Ala 50 55 Ala Met Ala Ile Ile Val Val Ser Leu Asn Ala Lys Asp Pro Asn Val 65 70 75 .I Leu Arg Lys Ile Val Phe Glu Lys Cys Leu Pro Asn Tyr Glu Lys Asn 90 Gin Asn Pro Ser Pro Cys Ile Glu Val Lys Pro Asp Ala Gly Tyr Val 100 105 110 Val Leu Lys Asp Ile Asn Gly Pro Leu Gin Tyr Leu Leu Met Pro Thr 115 120 125 Thr His Ile Ser Gly Ile Glu Asn Pro Leu Leu Leu Asp Pro Ser Thr 130 135 140 Pro Asn Phe Phe Tyr Leu Ser Trp Gin Ala Arg Asp Phe Met Ser Lys 145 150 155 160 Lys Tyr Gly Lys Pro Ile Pro Asp Tyr Ala Ile Ser Leu Thr Ile Asn 165 170 175 Ser Lys Lys Gly Arg Ser Gin Asn His Phe His Ile His Ile Ser Cys 180 185 190 Ile Ser Leu Asp Val Arg Lys Gin Leu Asp Asn Asn Leu Lys Asn Ile 195 200 205 Asn Ser Arg Trp Ser Pro Leu Ser Gly Gly Leu Asn Gly His Lys Tyr 210 215 220 1225 Leu Ala Arg Arg Val Thr Glu Ser Glu Leu Ala Gin Lys Ser Pro Phe 225 230 235 240 Val Met Leu Ala Lys Glu Val Pro Asn Ala His Lys Arg Met Gly Asp 245 250 255 Tyr Gly Leu Ala Val Val Gin Gin Ser Asp Asn Ser Phe Val Leu Leu 260 265 270 Ala Thr Gin Phe Asn Pro Leu Thr Leu Asn Arg Ala Ser Ala Glu Glu 275 280 285 Ile Gin Asp His Glu Cys Ala Ile Leu Arg 290 295 INFORMATION FOR SEQ ID NO:1683: SEQUENCE CHARACTERISTICS: LENGTH: 121 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...121 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1683 Tyr His Arg Thr Asn Thr Thr Ile Arg Ile Ile Ile Met Gin Asp Leu S1 5 10 Pro Pro Cys Pro Lys Arg Asn Asp Ala Tyr Thr Tyr His Asp Gly Thr 25 Gln Phe Val Cys Ser Ser Cys Leu Tyr Glu Trp Asn Gly Asn Glu Ile 35 40 S Ser Asn Glu Glu Leu Ile Val Lys Asp Cys His Asn Asn Leu Leu Gin 55 Asn Gly Asp Ser Val Ile Leu Ile Lys Asp Leu Lys Val Lys Gly Ser 65 70 75 Ser Leu Val Leu Lys Lys Gly Thr Lys Ile Lys Asn Ile Lys Leu Val 85 90 Asn Ser Asp His Asn Val Asp Cys Lys Val Glu Gly Gin Ser Leu Ser 100 105 110 Leu Lys Ser Glu Phe Leu Lys Lys Ala 115 120 INFORMATION FOR SEQ ID N0:1684: SEQUENCE CHARACTERISTICS: LENGTH: 75 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: 1226 NAME/KEY: misc_feature LOCATION 1...75 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1684 Lys Gly Cys Phe Met Arg Glu Phe Phe Lys Lys Leu Gly Thr Glu Tyr 1 5 10 Ala Ser Lys Leu Phe Leu Val Tyr Trp Leu Arg Trp Met Leu Ser Ala 25 Leu Val Met Leu Pro Phe Met Glu Val Phe Tyr Tyr Phe Asn Phe Pro 40 Leu Trp Leu Asn Leu Phe Leu Gly Gin Thr Ile Gly Ala Val Ile Phe 55 Phe Lys Leu Asp Lys Leu Ile Phe Ser Lys Lys 70 INFORMATION FOR SEQ ID NO:1685: SEQUENCE CHARACTERISTICS: LENGTH: 497 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori
S**
(ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...497 (xi) SEQUENCE DESCRIPTION: SEQ ID N0:1685 Phe Phe Lys Arg Tyr Glu Arg Leu Ser Met Gin Tyr Ser Ser Leu Leu 1 5 10 Ser Val Val Leu Phe Leu Pro Leu Ile Gly Ala Val Tyr Ala Gly Leu 20 25 Phe Gly Ala Lys Ala Lys Ala Leu His Val Gly Val Phe Asn Ser Leu 35 40 Cys Val Leu Val Ser Phe Ile Gly Ala Val Val Leu Phe Ile Gin Ala 50 55 Trp His His Gin Ser Tyr Glu Lys Tyr Leu Phe Asp Trp Ile Val Val 70 75 Gly Asn Phe Lys Val Gly Phe Ser Leu Met Leu Asp Asn Ile Asn Ala 90 Val Met Ile Val Val Val Thr Leu Val Ser Phe Leu Val His Val Tyr 100 105 110 Ser Ile Gly Tyr Met Glu His Asp Thr Gly Phe Asn Arg Tyr Phe Ser 115 120 125 Tyr Leu Ser Gly Phe Val Phe Ser Met Leu Val Leu Val Leu Ser Asp 130 135 140 Asn Phe Leu Gly Leu Phe Ile Gly Trp Glu Gly Val Gly Leu Cys Ser 145 150 155 160 Tyr Leu Leu Ile Gly Phe Trp Tyr His Lys Lys Ser Ala Asn Asn Ala 165 170 175 Ser Ile Glu Ala Phe Val Met Asn Arg Ile Thr Asp Leu Gly Met Leu 180 185 190 Met Gly Ile Ile Leu Ile Phe Trp Asn Phe Gly Thr Leu Gin Tyr Lys 195 200 205 Glu Val Phe Ser Met Leu Asn Asn Ala Asp Tyr Ser Met Leu Phe Tyr 1227 Ile Ser Val Phe Leu Phe Ile Gly Ala Met Pro Ser Ile Phe Al a 305 Ser Ile Phe Ile Phe 385 Gly His Phe His His 465 Ala Ile Met Ala Ile Ile 290 Leu Gin Ala Leu Thr 370 Met Tyr His Glu 450 Ala Val Asn Thr Tyr 280 Phe Lys Val Thr Met 360 Tyr Ala Ile Leu Met 440 Glu Gly Ser Ala Met 265 Ser Val1 Arg Ala His 345 His Lys Leu Leu Leu 425 Leu Gly Gly Ser Met 250 Val Ala Ala Ile Ala 330 Ala Ala Pro Cys Glu 410 Ile Val1 Gin His Giu 490 Lys Ser Ala Gin Phe 240 Gly Pro Thr Pro Val 255 Ala Gly Val Tyr Leu 270 Phe Glu Vai Gly Tyr 285 Phe Gly Ala Ser Met 300 Ala Tyr Ser Thr Leu 320 Leu Gly Ala Tyr Ala 335 Phe Lys Ser Leu Leu 350 Glu Asp Asn Leu Asp 365 Arg Ile Thr Ala Val 380 Ile Tyr Pro Phe Ala 400 Ala Phe Gly Met His 415 Ala Ile Phe Thr Ala 430 Phe Ala Pro Lys Gin 445 Phe His Ala Phe Giu 460 Arg Phe Phe Arg Arg 480 Leu Val Leu Glu Ser 9 *9*C 0* 99 a 9* INFORMATION FOR SEQ ID NO:i686: *6 SEQUENCE CHARACTERISTICS: LENGTH: 276 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE:- NAME/KEY: misc-feature LOCATION I. 276 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:l686 Asn Lys Pro Asn Lys Gly Ala Val Leu Glu Lys Thr Lys Lys Arg Gin 1 5 10 Leu Leu Gin Lys Lys.Thr Lys Lys Arg Ile Lys Gin Lys Arg Leu Pro 25 Gin Lys Lys Ile Lys Gin Lys Thr Arg Gin Arg Leu Lys Arg Lys Ile 40 Giu Val Pro Thr Lys Thr Thr Tyr Leu Leu Leu Giu Giu Ala Gly Ile 1228 55 Asn Leu Giu Thr Tyr Giu Lys Ile Leu Ala Leu Leu Gin Lys Ser Asn 70 75 Asn Thr Leu Leu Val Val Gly Giu Giu Ile Tyr Ser His Lys Gin Ala 90 His Asn Ile Ala Lys Met Leu Arg Leu Leu Ala Gin Lys Ser Ala Ile 100 105 110 Lys Leu Ile Leu Ile Pro Pro Ser Ala Asn Ala Leu Giy Ile Ala Ser 115 120 125 Ile Cys Giu Leu Ser Giu Giu Val Phe Giu His Giu Lys Ile Val Giy 130 135 140 Ile Arg Ala Gin Gly Asp Phe Thr Ile Asn Ser Asp Asp Arg Val Phe 145 150 155 160 Gly Lys Asp Ala Val Ser Lys Vai Asp Phe Ile Leu Pro Ser Leu Asn 165 170 175 Gin Leu Giu Giy Thr Ile Thr Asn Val Giu Gly Arg Val Leu Pro Leu 180 185 190 Lys Pro Ala Leu Arg Phe Giu Gly Tyr Asp Leu Ser Asp Ile Met Gin 195 200 205 Gly Phe Gly Phe Val Giu Giu Asn Leu Thr Giu Cys Thr His Lys Leu 210 215 220 Pro Thr Giu Ala Gly Phe Lys Ala Leu Giu Phe Asp His Leu Thr Asn 225 230 235 240 Tyr Phe Thr Asn Asp Arg Ala Asn His Arg Gly Tyr Leu Leu Gly Thr 245 250 255 Ser His Phe Giu Asn Ser Ala Lys Giu Ser Lys Pro Gin Asn Ala Ser *260 .265 270 Leu Ser Ser Leu 275 INFORMATION FOR SEQ ID NO:1687: SEQUENCE CHARACTERISTICS: LENGTH: 223 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .223 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i687 Gly Gly Phe Met Ala Lys-Gin Giu Tyr Lys Gin Leu Pro Lys Arg Ala 1 5 10 Giu Val His Sen Ala Thr Giu Gin Phe Lys Asp Thr Ile Lys Thr Sen 25 Leu Gly Leu Asp Leu Phe Lys Gly Leu Gly Leu Thr Ile Lys Giu Phe 40 Phe Ser Pro Ser Val Thr Ile His Tyr Pro Met Giu Gin Leu Pro Leu 55 Sen Pro Ang Tyr Arg Ala Vai His His Leu Gin Ang Leu Leu Asp Sen 70 75 Gly Ser Giu Arg Cys Ile Gly Cys Giy Leu Cys Glu Lys Ile Cys Thr 90 Sen Asn Cys Ile Ag Ile Ile Thr His Lys Gly Giu Asp Asn Ang Lys 100 105 110 1229 Lys Ile Asp Ser Tyr Thr Ile Asn Leu Gly Arg Cys Ile Tyr Cys Gly 115 120 125 Leu Cys Ala Giu Val Cys Pro Glu Leu Ala Ile Val Met Gly Asn Arg 130 135 140 Phe Giu Asn Ala Ser Thr Gln Arg Ser Gln Tyr Gly Ser Lys Ser Glu 145 150 155 160 Phe Leu Thr Ser Glu Gin Asp Ala Lys Asfl Cys Ser His Ala Giu Phe 165 170 175 Leu Giy Phe Gly Ala Val Ser Pro Asn Tyr Asn Glu Arg Met Gin Ala 180 185 190 Thr Pro Leu Asp Tyr Vai Gin Giu Pro Ser Lys Glu Giu Ser Lys Giu 195 200 205 Giu Ser Pro Thr Ser Pro Giu Ser His Lys Giy Asp Glu Asn Val 210 215 220 INFORMATION FOR SEQ ID NO:i688: SEQUENCE CHARACTERISTICS: LENGTH: 208 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY misc-feature LOCATION 1. .208 (xi) SEQUENCE DESCRIPTION: SEQ ID N0:1688 Ile Met Sen Lys Asn Leu Gin Lys Lys Asn Pro Lys Lys Sen Leu Gin t.1 5 10 Gin Ala Gin Lys Ala Ile Arg Glu Met Lys Met Phe Glu Thr Ile Ala 25 Phe Tyr Phe Phe Ala Ile Leu Thr Leu Sen Met Ala Leu Val Val Ile 40 Thr Thn Thr Asn Ile Leu Tyr Ala Ile Thr Ala Leu Ala Ser Sen Met s0 55 Val Phe Ile Ser Ala Phe Phe Phe Leu Leu Asp Ala Glu Phe Leu Gly ~:65 inle 70 75 Val Val GnIeThn Val Tyr Val Gly Ala Val Ile Vai Met Tyr Ala 90 Phe Gly Met Met Phe Phe Asn Ser Ala Ala Glu Val Vai Giu Arg Lys 100 105 110 Gin Ser Pro Lys Ile Leu Cys Val Leu Sen Phe Gly Val Ala Leu Leu 115 120 125 Leu Thr Leu Ile Leu Ser Ala Pro Sen Ile Gly Giu Asn Leu Ser Lys 130 135 140 Gin Val Asn Ser Asn Ala Ile Asp Aia Gin Ile Pro Asn Ile Lys Ala 145 150 155 160 Ile Gly Tyr Val Leu Phe Thr Asn Tyr Leu Ile Pro Phe Glu Ala Ala 165 170 175 Ala Leu Met Leu Leu Val Ala Met Val Gly Gly Ile Ala Thr Gly Ile 180 185 190 Gin Lys Ile His Gly Lys Asn His Thr Gin Phe Ile Lys Giu Ser Leu 195 200 205 INFORMATION FOR SEQ ID NO:1689: 1230 SEQUENCE CHARACTERISTICS: LENGTH: 246 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/=E: misc-feature LOCATION .246 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1689 a a. a a a a Met 1 A-sn Ile Gly Trp Phe Ala Lys dly Ala 145 TIyr Val Thr Ile Asn 225 Tyr Lys Gln Gly Leu 50 Tyr Thr Asn Asn Gly 130 Thr Pro Asn His Asn 210 Ala Lys Gly Sen Ala Gly Asp 115 Glu Phe Asn Asn Thn 195 Ser Asn Thn Phe Trp Ile Asn 100 Asn Tyr Asn dly Sen 180 Gly Asn Sen Ile A~la 3 ly I'rp Gin His Gly Asn Leu His 165 Val Thr .le Val Leu Ser Glu Sen 70 Leu Sen Thn Gly Gly 150 Thr Glu Ala Sen Ile Lys Gly Lys 55 Cys Ile Gin Tyr Gly 135 Ala Asp Val Thr Ala 215 Ang Val 40 Sen Asp Thn Asn Phe 120 Asn Ser Val Giy Leu 200 Tyr Pro 25 T'yr Gln L.ys Lys Asn 105 Leu Leu Sen Thr Asn 185E Asn Lys Gin Phe Lys Lys Lys Pro Lys Lys 10 Leu Ala Lys Trp Thr 90 Gin Ser Asp *Gly *Phe 170 Ang Leu Thr Trp Asp Val G iu 75 Trp Asp Gly Ile Asn 155 Ser Val1 Asn Sen Leu Gly Cys Giu Ala Ile Leu G iu 140 Ser Ala Giy Ala Gin 220 Met Thn Val1 Lys Gly Thn 125 Leu Phe Gly Sen Asn 205 Val Ile Lys Arg Ser His Gin Pro Leu Leu Asp Ile Leu His Ang Pro Thr Gin Gin Gly Asn Ala Ala Asn Leu 110 Asn Tyr Thn Gly Ser Asn Thr Ser Tnp 160 Thr Ile Asn 175 Giy Ala Giy 190 Lys Val Thr Asn Val Gly Asn Gly Giu Thr Ile Asn Sen Val Ser Leu Leu Gin Phe Phe Sen 245 INFORMATION FOR SEQ ID NO:1690: SEQUENCE CHARACTERISTICS: LENGTH: 400 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: 1231 ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .400 S. S
I
f (xi) SEQUENC lal Phe Thr Pro 1 Leu Ile Leu His Ile Ser Leu Ala Ala Sen Leu Ile Ala Lys Asp Lys Thr Gly Ser Phe Leu Gin Thr Gin 100 Leu Leu Giy Ile 115 Giu Ile Tyr Ile 130 Giu Ile Thr Arg 145 ily Giu Gin His Thr Lys Ala Glu 180 Tyr Ser Vai Glu 195 Ile Asp Tyr Ser 210 Thr Ser Phe Glu 225 Lys Vai Leu Gly Ile Ala Lys His 260 Phe Giu Leu Lys 275 Gin Lys Ile Ile 290 Leu Giu Gly Ile 305 Val Thr Pro Gly Ala Gin Lys Ile 340 Leu Asn Sen Lys 355 Leu Leu Lys Asp 370 E DESCRIPTION: SEQ ID NO:i690 5 Glu Leu Phe Ile Gly Phe Ala Ala Leu Leu 165 Leu Lys Sen Thr Glu 245 Leu Pro Ile Arg Leu 325 Asp Thr Lys Leu Ile I Gly Glu Ala 70 Lys Asn Asn Glu Ile 150 Glu Leu Ile Leu Leu 230 Phe Gly Ile Asp Leu 310 Val Gly Ile Ala Ile 390 Leu Tyr Lys 55 Ser Thr Ala Asp Ala 135 Glu Tyr Asp Lys Val 215 Ile Asn Leu Asn Asp 295 Ala Glu Val Ala Gin 375 Leu Asn Leu 40 Val Leu Ser His Ile 120 Gly Pro Phe Sen Pro 200 Arg Asn Ala Glu His 280 Ser Sen Ser Phe Sen 360 Leu Phe rhr 25 :ys Leu Lys Ihr Ala 105 Asn Ala His Lys Lys 185 Tyr Asn Gly Tyr Thr 265 Arg Phe Leu Asn Asp 345 Lys Glu Ala
LO
lu Leu Ser Asn Lys 90 Ser Gin Arg Leu Thn 170 Arg Ala Val Val Asn 250 Glu Leu Asn His Thr 330 Val Leu Asn Leu Phe Lys Leu 75 Asn Pro Asn Asn Ala 155 Leu Leu Pro Gin Trp 235 Ile Arg Gin Gly Gin 315 Glu Ala Lys Ile Ala Ile Gin Lys Phe Lys Leu Lys 140 Val Glu Glu Lys Ser 220 Glu .Ala Ile Leu Asn 300 Gly Sen Ile Thr Leu 380 Pro Leu Tyr Va1 Leu Ser Asp 125 dly Val Asn Lys Asp 205 Thn Ser Sen Lys Leu 285 Leu Arg Asn Ile Pro 365 Gin Leu Val Leu Ile a His Val 110 Asp Asp Ala Ile Ala 190 Ser Leu Phe Ala Arg 270 Glu Lys Lys Glu Thr 350 Gin Ala ksn Leu GIn Ala GIn Asn Arg Ile Glu Cys 175 Phe Pro Lys Glu Ile 255 Leu Ala Gly Val Ala 335 Gly Lys Thr Gly Ser Thr Ile Ile Thr Ser Lys Va1 160 Glu Cys Leu Gly Thr 240 Leu Va1 Asn Met Ile 320 Leu Glu Ile Thr Arg Val Lys Arg Phe Phe Ile Phe Leu Phe Leu Phe Ile 385 Gin Gly Asp Thr Asp Ala Pro Asn Tyr Ile INFORMATION FOR SEQ ID NO:1691: SEQUENCE CHARACTERISTICS: LENGTH: 717 aminO acids TYPE: amino acid 1232 TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...717 a
I
C
2 (xi) SEQUENC] 'yr Ala Leu Lys
L
'he Val Gly Leu lal Tyr Leu Thr Tyr Ile Asn Phe Crp Ala Asn Val 65 Gly Phe Cys Lys ?he Ile Leu Gly 100 \sp Lys Pro Leu 115 [hr Ala Cys Val 130 Ile Ile Thr Asp 145 Arg Gin Lys Phe Asp Asp Asn Thr 180 Lys Met Thr Phe 195 Gly Ile Phe Val 210 Leu Phe Val Phe 225 Ser Phe Tyr Asp Ile His Pro Lys 260 Lys Thr Gly Glu 275 Asn Pro Gin Ala 290 Gin Lys Tyr Ile 305 Pro Glu Pro Pro Thr Asp Ala Arg 340 Ile Met Ser Ser 355 Val Arg Glu Ala 370 Ser Leu Arg Gin Ala 5 Tyr Met Pro Lys Val Lys Gly Ala Ile Leu 165 Cys Ala Asp Phe Val 245 Ser Val Asn Asp Tyr 325 Ser Phe Thr His Gly Leu Ile Lys Thr 55 Asp Ile 70 Val His Phe Gly Thr Met Leu Pro 135 Lys Gly 150 Asn Asn Tyr Phe Glu Gin Glu Glu 215 Ala Leu 230 Ser Ile Pro Tyr Ile Leu Val -Leu 295 Met Asn 310 SGly Thr STrp Ala Lys Arg Ser Lys 375 Ala Ser 40 Thr Glu Arg Phe Ile 120 Asn Glu Arg Asn Leu 200 Asp Leu Ala Tyr Asp 280 Lys Asp Lys Asn Phe 360 Met Ser 25 Leu Glu Cys Leu Pro 105 Val Leu Leu Ile Pro 185 Arg His Gin Pro Lys 265 Pro Leu Glu Gly Thr 345 Met Ser
'I
E DESCRIPTION: SEQ ID NO:1691 Tyr 10 Ile det rhr Phe Gly 90 Lys Ala Leu Arg Leu 170 Phe His Trp Val Ala 250 Gin Gin Phe Lys Ala 330 Pro Tyr Phe Phe Phe Ser Phe Asp Leu Pro Phe Val Ser His Gly Lys Ile Phe 75 Val Gin Phe Leu Arg Asn Pro Pro Gly 125 Thr Leu Pro 140 Asp Lys Thr 155 Ile Phe Asn Asp Lys Arg Val Lys Ala 205 Val Ser Lys 220 Val Thr Lys 235 Asn Asp Tyr Leu Tyr Gin Thr Asn Ala 285 Leu Asn Gin 300 Asn Tyr Asp 315 Leu Asp Glu Asp Asp Glu Val Tyr Lys 365 SAsp Tyr Glu G1n Lys Ala Tyr Ser Asp Val 110 Ala Asn Ala Pro Ile 190 Val Ala Gly Ala His 270 Pro Val Pro Ile Phe 350 Asp Gl.
Ser Phe Thr Ala Lys Asn Cys Gly Ser Gly Tyr 175 Val Gly Lys His Pro 255 Asp Met Ala Arg SIle 335 SGly Pro SLeu Val Glu Ile Arg Glu Gly Tyr Lys Cys Tyr 160 Gly Glu Asp Glu Ser 240 Leu Lys Lys Asp Glu 320 SArg SSer Lys Arg Thr Gly Asn Ile Ser Ile Tyr Ile Val Ile 385 390 380 Ala Gin Ile Asp Ile Gly 395 400 1233 Thr Leu Ala Pro Asp 465 Leu Giu Ser Ser Met 545 Ala Leu Arg Asn Giu 625 Pro Glu Asn Ser Giu 705 Vai Arg Ala Phe Leu Giu Ser Ile Ala Lys Gly 440 Asn Tyr Asn Lys Lys 520 Arg Val Ala Pro Pro 600 Glu Asn As n Asn Ile 680 Leu Thr Pro 425 Lys Val Tyr Ile Glu 505 Gly Asn Ile Asn Ile 585 Thr Pro Thr Leu Ala 665 Leu Phe Gin Giu Arg Pro Phe Pro Leu 460 Asp Asp 475 Phe Lys Giy Giu Leu Val Leu Thr 540 Ile Val 555 Trp Phe Leu Glu Giu Ile Asn Lys 620 Giu Asn 635 Giu Ser Giu Asn Lys Pro Lys Met 700 Thr -Gln 715 Ile Leu 445 Phe Asp Met Phe Phe 525 Ala Thr Lys Val1 Giu 605 Gly Asn Giu Ile Leu 685 Gin Ser Lys Asn 415 Ile Ile Giu Met Thr Gin Lys Ile 480 Ser Ala 495 Arg Arg Gly Ser Asp Ile Ala Lys 560 Lys Giu 575 Arg Gin Thr Pro Lys Val Thr Thr 640 Asp Asn 655 Gin Giy Giu Ile Ser Asp 9 p* 9 p 4**p p. *e p p p p p p p pp..
p.
p p INFORMATION FOR SEQ ID NO:1692: SEQUENCE CHARACTERISTICS: LENGTH: 2440 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc...feature LOCATION1 .2440 (xi) SEQUENCE DESCRIPTION: SEQ ID N0:1692 Tyr Asn His Pro Asn Leu Sen Val Ala Asp Leu Giu Leu Giu Gin Gin 1S 10 Asn Leu Gly Giu Gin Asn Gly Lys Giu Arg Thr Asn Arg Ala Asp Giu 1234 *0* 0. 0 Pro Giu Leu Gly Giu Asp Ser dly 145 Pro Arg Gin Ser Asp 225 Ser Leu Giy Ser Thr 305 Gin Lys Ser Ile Gin 385 Thr Gin Giu Gin Ala 465 Leu Giy Lys Thr Asn Pro s0 Ser Thr Ser Giy Ser 130 Asp Ser Giu Met Asp 210 Lys Giu Pro Leu Asn 290 Ile Asn Asp Pro Giu 370 Aia Gin Glu Gin Thr 450 Pro Asn Ala Giu Leu 530 Giy Arg His Arg His Vai 11iS Pro Asn His Gin Giy 195 Asn Ser Arg Ala Arg 275 Leu Ala Asn Pro Lys 355 Thr Ile Glu Gin Thr 435 Thr Thr Pro Lys Leu 515 Lys Thr Gly Gin Giy Arg 100 Ser Ala Pro Gin Pro 180 Ser Giu Pro Tyr Gin 260 Asp Asp Ser Asp Thr 340 Lys Thr Asp Ser Thr 420 Thr Gin Thr Lys Thr 500 Gin Giu Arg Gin Asp Val1 Giu Ala Ser Ser Gin 165 Giy Leu Leu Arg Gly 245 Ser Leu Asn G iu Pro 325 Thr Val Asn Leu Lys 405 Ala Gin Giu Ile Ile 485 Arg Ala Gin Ala Gin Pro 70 Tyr Arg Arg Arg Asp 150 Asn Gin Phe Asp Gin 230 Ile Arg Giu Leu Pro 310 Leu Lys Leu Giu Asn 390 Ile Gin G iu Gin Lys 470 Asp Tyr Lys Glu Gly Giu 55 Ser Arg Asp Ala Met 135 Giu Ser Thr Pro Arg 215 As n Ala Leu Giu Glu 295 Asp Lys Ile Giu Thr 375 Ala Thr Giu -Gin Thr 455 Gin Phe Lys Gin Ile 535 Ile 40 Gly Leu Ser Arg Asp 120 Giu Arg Ser Gly Thr 200 Arg Gly Gin His Asn 280 Ser Phe Asp Phe Ile 360 Leu Ile Asp Gin Thr 440 Thr Giu Lys Ala Glu 520 Leu Pro Met Phe Ser Ile 105 Ala Asn Giy Arg Arg 185 Asp Ser Ser Gly His 265 Arg Leu Arg Ser 345 Leu Asn Ser Asn Thr 425 Thr Gin Thr Pro Asn 505 Ile Ala Gin Giu Ile Asp 90 His Arg Giy Ile Asp 170 Leu His Asp Ala Ser 250 Ala Asp Leu Ser Ile 330 Asp Giu Ala Asn Ser 410 Thr Gin Giu Pro Ser 490 Ile Leu Gin Giu Arg Giu 75 Gin Giu Ala Ala Pro 155 Leu Arg Giu Lys Asn 235 Ser Gly Gin Asn Arg 315 Val1 Lys Asn Phe Ser 395 Val Gin Giu Gin Ile 475 Giu Lys Lys Phe Ile Ser Ser Gin His Asn Arg 140 Gin Gly Leu Asn Ala 220 Gin Asn Leu Giu Ala 300 Leu Gly Phe Arg Asn 380 Val1 Giu Glu Gin Asp 460 Thr Giu Ala Gly Ser 540 His Ser Arg Ala Val1 Ser 125 Ser Thr Leu Phe Gin 205 Asn Giu Gin Ser G ly 285' Ile Leu Ala Gin Leu 365 Val Gly Leu Gin Thr 445 Thr Pro Val1 Ile Asp 525 Gly Arg Asp Giu Val Ser 110 Asn Giu Pro Ser Asp 190 Arg Giu Ser Ser Ala 270 Arg Arg Giu Gin Leu 350 Lys Leu Leu Asn Thr 430 Thr Gin Ala Leu Giu 510 Tyr Trp, Arg Ser Glu Asp Gin Gly Ser Giu Arg Gly Gly Ala Giu Lys Gin Ser 160 Leu Ser 175 His Gly Lys Arg Asn Gly Ala Arg 240 Val Leu 255 Gin Asn Leu Leu Asn Asn Ala Ile 320 Leu Leu 335 Lys Ile Lys Ser Asp Ser Asn Pro 400 Asn Ala 415 Thr Gin Gin Giu Giu Asn Ile Pro 480 Ile Lys 495 Leu Leu Tyr Ala Gly Gly 1235 O 9ooo S* Leu Glu Ser 545 Leu Asn Ala Ala Arg Asp Gin Gly Leu 595 Ile Phe Glu 610 Ser Asp Lys 625 Ala Asn Leu Ala Leu Glu Asn Pro Pro 675 Leu Ser Asn 690 Glu Leu Lys 705 Met Asp Ala Thr Phe Leu Gly Ala Glu 755 Lys Ala Thr 770 Ile Leu Asn 785 Arg Phe Asp Val Ala Asn Glu Lys Ile 835 Ile Ile Lys 850 Asn Glu Gin 865 Leu Gly His Gly Glu Gin Leu Asp Leu 915 Asp Val Tyr 930 Ile Asp Ser 945 Asn Leu Glu Leu Glu Gin Asn Ser Lys 995 Asp Ala Leu 1010 Asp Leu Glu 1025 Glu Phe Val Tyr Leu Ala 580 Asp Pro Asn Ser Asn 660 Tyr Glu Asp Lys Gly 740 Val Asn Ser Ser His 820 Asp Asp Thr Leu Ile 900 Ser Gin Ser Arg Asn 980 Val Asn Leu Lys Phe Leu 565 Tyr Gin Ser Tyr Lys 645 Tyr Gly Ser Asp Asn 725 Ala Thr Gin Leu Phe 805 Phe Thr Phe Leu Ser 885 Tyr Gin Tyr Asn Arg 965 Asn Gin Asp Glu Lys 550 Thr Tyr Leu Leu Arg 630 Phe Gin Asn Ile Gly 710 Pro Ile Ser Ser Asp 790 Ile Gly Ala Ile Asn 870 Leu Lys Ala His Glu 950 Glu Glu Asp Leu Asn Lys Ala Gin Lys Asp Glu Thr Pro Lys 585 Gly Phe Asn 600 Gly Thr Gly 615 Phe Ile Gly Leu Tyr Pro Phe Tyr Gin 665 His Lys Ile 680 His Asn Tyr 695 Ile Gly Ala Lys Met Arg Arg Leu Pro 745 Asp Ile Val 760 Phe Thr Lys 775 Asp Asp Thr Pro Ser Asp Phe Lys Gin 825 Asn Phe Gly 840 Asp Lys Val 855 Glu Tyr Phe Glu Lys Thr Tyr Asp Leu 905 Leu Lys Gin 920 Lys Thr Thr 935 Arg Tyr Gin Leu Val Lys Met Gly Ile 985 Ser Arg Leu 1000 Thr Ser Ala 1015 Lys Arg Ala 0 Gly Tyr Leu His Phe 570 Leu Asn Lys Thr Asn 650 Glu Tyr Phe Phe Glu 730 Asn Phe Ala Leu Gin 810 Glu Tyr Gly Ile Arg 890 Gln Ala Leu Glu Trp 970 Phe Lys Glu Lys Asn Pro 555 Arg Val Asp Phe Glu 635 Gin Tyr Ser Leu Val 715 His Ser Phe Met Phe 795 Leu Lys Ser Lys His 875 Tyr Ala Ile Lys Val 955 Asp Leu Ala Leu Glu Arg Ile Asn Ile 620 Leu Val Asp Ser Gly 700 Val Ile Val Lys Pro 780 Ala Lys Leu Thr Asn 860 His Arg Leu Glu Thr 940 Gin Asn Lys Tyr Asn Glu Phe Ala Tyr Asp Ser 590 His Pro 605 Ala His Asp Pro Ile Gin Ala Phe 670 Asn Asp 685 Lys Ala Ser Ser Ala Lys Phe Lys 750 Lys Gly 765 Tyr Tyr Leu Gin Ile Val Gin Arg 830 Gin Asp 845 Ser Ile Pro Glu Phe Glu Glu Asp 910 Lys Leu 925 Asp Val Lys Leu Leu Tyr Pro Thr 990 Phe Lys 1005 Pro Leu Lys Leu 575 Ile Lys Ala Ile Asn 655 Val Lys Ile Trp Asn 735 Ala Val Asp Asn Asn 815 Trp Tyr Asn Asn Thr 895 Glu Pro Leu Ile Phe 975 Lys Ile Ser Glu 560 Ser Tyr Lys Pro Ser 640 Thr Gly Glu Lys Phe 720 Ala Thr Glu Lys Asn 800 Ala Tyr Lys Leu Ile 880 Asn Ser Lys Ile Lys 960 Gin Ile Lys Ser 1020 Leu Asn Leu 1035 Glu Asn Lys 103 Lys Phe Tyr Asp 1040 Arg Lys 1055 Glu Lys Asp Ile Arg Gin 1045 Asp Leu Tyr Gly 1050 Ala Lys Val Leu Gly Leu 1236 1060 106S 1070 Asp Phe Giu Lys Giu Ile Thr Pro Arg Ser Ala Lys Met Gin Asn Ile 1075 1080 1085 Giu Pro Arg Gin Ala Gin Ala Lys Lys Ala Gin Ile Phe Phe Giu Arg 1090 1095 1100 Thr Leu Asn Pro Lys Lys Glu Leu Ile Ile Thr Asn Ala Lys Glu Ala 1105 1110 1115 1120 Leu Ile Ala Ser Ile Asn Gin Lys Gly Gly Leu Asp Leu His Phe Ile 1125 1130 1135 Arg Asp His Phe Thr Thr Gin Ser Leu Giu Thr Thr Ile Lys Giu Leu 1140 1145 1150 Leu Giu Gin Lys Leu Ile Tyr Lys Asp His Lys Asp Asn Gly Giy Tyr 1155 1160 1165 Ile Leu Ala Asn Asp Tyr Leu Ser Giy Asn Val Lys Arg Lys Leu Lys 1170 1175 1180 Giu Val Lys Giu Ala Ile Asn Gin Gly Val Giu Gly Leu Giu Ala Asn 1185 1190 1195 1200 Vai Lys Asp Leu Giu Leu Ile Ile Pro Lys Asp Leu Lys Ala Thr Giu 1205 1210 1215 Ile Met Ala As Ile Asn Ser Pro Trp Ile Pro Thr Gin Tyr Leu Giu 1220 1225 1230 Giu Phe Leu Met Giu Leu Ser Ala Asn His Tyr Glu Lys Gin T'yr Gly 1235 1240 1245 Asp Lys Met Thr Asp Tyr Gin Leu Ser Asn Leu Lys Giu Asp Ile Lys 1250 1255 1260 Ile Giu His Leu Ser Gly Ala Tyr Giu Val Phe Val Arg Asn Asn Giu :**1265 1270 1275 1280 Leu Asn Giu Leu Tyr Giy Ile Arg His Lys Asp Lys Pro His Ser Tyr 1285 1290 1295 Lys Val Pro Phe Giu Ser Leu Leu Asn Lys Val Leu Asn Asn Lys Asp 1300 1305 1310 *Leu Ser Val Lys Tyr Ala Gin Val Asp Pro Asn Asp Pro Lys Lys Giu 1315 1320 1325 Ile Phe Ile Thr Asp Giu Glu Gin Ser Asn Leu Ala Arg Gin Lys Ala Giuu Leu Ly Giu Ala Ph y Asp r Ile TrLys Asp Tyr;Ser 1351350 1355 16 AgArg Thr His Leu Giu Gin Ile Tyr Asn Asp Thr Phe Asn Asn Phe 136513017 Val Leu Lys Thr Tyr Asp Gly Ser Gin Leu Giu Leu Giu Giy Phe Asn *1380 1385 1390 Tyr His Ile Ser Leu Arg Pro His Gin Lys Asn Ala Ile Phe Arg Thr 1395 1400 1405 Ile Gin Asp Arg Ala Vai Cys Leu Asp His Gin Val Gly Ala Gly Lys *Tr1410 1415 1420 TrLeu Cys Ala Ile Ala Ser Cys Met Giu Gin Lys Arg Met Gly Leu 1425 1430 1435 1440 Val Asn Lys Thr Leu Ile Ala Val Pro Asn His Leu Thr Lys Gin Trp 1445 1450 1455 Gly Asp Giu Phe Tyr Lys Ala Tyr Pro Asri Ala Asn Val Leu Val Val 1460 1465 1470 Asp Ser Lys Asp Thr Thr Glu Lys Giu Arg Glu Leu Leu Phe Asn Gin 1475 1480 1485 Ile Ala Asn Asn Asn Tyr Asp Ala Val Val Ile Ala His Thr His Leu 1490 1495 1500 Glu Leu Leu Ser Asn Pro Arg Gly Ile Ile Glu Glu Leu Lys Giu Giu 1505 1510 1515 1520 Glu Leu Val Asn Ala Giu Lys Asn Phe Giu Arg Gin Giu Leu Ala Tyr 1525 1530 1535 Lys Asn Asn Pro Arg Giu Thr Lys Lys Pro Asn Glu Arg Ala Phe Lys 1540 1545 1550 Asn Lys Leu Asp Lys Ile Arg Ala Lys Tyr Asp Ala Ile Leu Giu Lys 1555 1560 1565 Gin Gly Ser His Ile Asp Ile Ser Gin Met Gly Ile Asp Asn Leu Ile 1570 1575 1580 1237 Val Asp Glu Ala His Leu Phe Lys Asn Leu Ala Phe Glu Thr Ser Met 1585 1590 1595 1600 Glu Lys Ile Ala Gly Leu Gly Asn Gin Gln Gly Ser Asn Arg Ala Arg 1605 1610 1615 Asp Leu Phe Ile Lys Thr Arg Tyr Leu His Gln Asn Asp Lys Lys Ile 1620 1625 1630 Met Phe Leu Thr Gly Thr Pro Ile Ala Asn Ser Leu Ser Glu Met Tyr 1635 1640 1645 His Leu Gin Arg Tyr Leu Thr Pro Asp Val Leu Lys Glu Arg Gly Leu 1650 1655 1660 Glu Phe Phe Asp Asp Trp Ala Lys Thr Tyr Gly Glu Val Val Asn Asp 1665 1670 1675 1680 Phe Glu Leu Asp Thr Ser Ala Gin Ser Tyr Lys Met Val Asn Arg Phe 1685 1690 1695 Ser Lys Phe Ser Asp Val Gin Gly Leu Ser Thr Met Tyr Arg Ala Phe 1700 1705 1710 Ala Asp Ile Val Ser Asn Asp Asp Ile Leu Lys His Asn Pro His Phe 1715 1720 1725 Val Pro Lys Val Tyr Gly Asp Lys Pro Ile Asn Val Val Val Lys Arg 1730 1735 1740 Ser Glu Glu Val Ala Gin Phe Ile Gly Val Ala Leu Glu Asn Gly Lys 1745 1750 1755 1760 Tyr Asn Glu Gly Ser Ile Ile Asp Arg Met Gin Lys Cys Glu Gly Lys 1765 1770 1775 Lys Ser Gin Lys Gly Gin Asp Asn Ile Leu Ser Cys Thr Thr Asp Ala 1780 1785 1790 Arg Lys Val Ala Leu Asp Tyr Arg Leu Ile Asp Pro Asn Ala Lys Val .:..1795 1800 1805 ,Glu Lys Glu Phe Ser Lys Ser Tyr Ala Met Ala Lys Asn Ile Tyr Glu 1810 1815 1820 Asn Tyr Leu Glu Thr His Ala Thr Lys Gly Thr Gin Leu Gly Phe Ile S1825 1830 1835 1840 SGly Leu Ser Thr Pro Lys Thr His Ser Gin Lys Val Ser Leu Glu Ala 1845 1850 1855 Leu Asp Asn Ala His Glu Thr Glu Asn Lys Asn Pro Leu Asp Lys Ala 1860 1865 1870 S Gin Glu Leu Leu Glu Ser Leu Ser Ser Tyr Asp Glu Lys Gly Asn Leu 1875 1880 1885 Ile Ala Pro Ser Lys Lys Glu Leu Glu Asn Glu Leu Lys Glu Lys Glu 1890 1895 1900 Ala Lys Ser Val Asn Leu Asp Glu Glu Ile Ala Lys Gly Cys Ser Phe S1905 1910 1915 1920 Asp Val Tyr Ser Asp Val Leu Arg His Leu Val Gin Met Gly Ile Pro 1925 1930 1935 Gin Asn Glu Ile Ala Phe Ile His Asp Ala Lys Thr Glu Glu Gin Lys 1940 1945 1950 Gin Asp Leu Phe Lys Lys Leu Asn Arg Gly Gly Val Arg Val Leu Leu 1955 1960 1965 Gly Ser Pro Ala Lys Met Gly Val Gly Thr Asn Val Gin Glu Arg Leu 1970 1975 1980 Val Ala Met His Glu Leu Asp Cys Pro Trp Arg Pro Asp Glu Leu Leu 1985 1990 1995 2000 Gin Met Glu Gly Arg Gly Ile Arg Gln Gly Asn Ile Leu His Gin Asn 2005 2010 2015 Asp Pro Glu Asn Phe Arg Met Lys Ile Tyr Arg Tyr Ala Thr Glu Lys 2020 2025 2030 Thr Tyr Asp Ser Arg Met Trp Gin Ile Ile Glu Thr Lys Ser Lys Gly 2035 2040 2045 Ile Glu Gin Phe Arg Asn Ala His Lys Leu Gly Leu Asn Glu Leu Glu 2050 2055 2060 Asp Phe Asn Met Gly Ser Ser Asn Ala Ser Glu Met Lys Ala Glu Ala 2065 2070 2075 2080 Thr Gly Asn Pro Leu Ile Ile Glu Glu Val Lys Leu Arg Ala Glu Ile 2085 2090 2095 Lys Ser Glu Glu Set Lys Tyr Lys Ala Phe Asn Lys Glu His Tyr Phe 1238 2100 2105 2110 Asn Glu Glu Ser Leu Lys Asn Asn Ala Ser Lys Leu Asp Tyr Leu Lys 2115 2120 2125 Gin Glu Leu Lys Asp Leu Glu Thr Leu Gin Arg Ser Val Ile Ile Pro 2130 2135 2140 Thr His Thr Glu Ile Lys Leu Tyr Asp Leu Lys Asn Glu Glu Ser Lys 2145 2150 2155 2160 Asp Tyr Glu Leu Ile Lys Val Lys Glu Val Glu Pro Leu Lys Glu Asn 2165 2170 2175 Ala Ser Met Ser Glu Glu Leu Thr His Lys Lys Leu Lys Glu Gin Asn 2180 2185 2190 Lys Gin Ile Ala Glu Gin Asn Lys Glu Lys Leu Asp Ala Ile Lys Lys 2195 2200 2205 Gin Phe Ala Ser Asn Leu Asn Thr Leu Phe Val Asn Glu Glu Glu Asp 2210 2215 2220 Tyr Lys Leu Leu Glu Tyr Lys Gly Phe Val Val Asn Ala Tyr Lys Thr 2225 2230 2235 2240 Lys Tyr Gin Val Glu Phe Ser Leu Ser Pro Lys Asp Asn Pro Asn Ile 2245 2250 2255 Ala Tyr Ser Pro Ser Asn Met Val Tyr Lys Asn Asp Thr Ile Asn Met 2260 2265 2270 Phe Ser Ser Tyr Asn Phe Cys Ala Glu Ile Lys Phe Asp Gly Phe Leu 2275 2280 2285 Lys Arg Leu Asp Asn Ala Ile Thr Lys Leu Pro Glu Lys Ile Lys Glu 2290 2295 2300 Leu Glu Asn Ser Ile Glu Ile Thr Lys Lys Asn Ile Ala Lys Tyr Thr 2305 2310 2315 2320 Arg Leu Val Glu Gin Lys Pro Ser Tyr Pro Arg Leu Glu Tyr Leu Gin 2325 2330 2335 Ala Leu Lys Trp Asp His Lys Thr Leu Ile Asp Asp Leu Ala Lys Met 2340 2345 2350 Ser Lys Asp Arg Asn Tyr Lys Pro Ala Phe Asn Pro Lys Ser Lys Glu 2355 2360 2365 Val Leu Lys Asn Leu Asn Ala Glu Lys Arg Ala Ser Leu Glu Asn Glu 2370 2375 2380 Arg Glu Glu Gin Gly Val Lys Gly Asn Thr Lys Ser His Asp Glu Ile 2385 2390 2395 2400 Glu Pro Ala Thr Glu Gin Val Ile Glu Lys Glu Ile Glu Lys Gly Asp 2405 2410 2415 Glu Ile Ala Asn Asn Val Asp Tyr Tyr Glu Asn Glu Gin Glu Val Glu 2420 2425 2430 *Ile Thr Lys Ser Met Gly Arg Arg *oo 2435 2440 INFORMATION FOR SEQ ID NO:1693: SEQUENCE CHARACTERISTICS: LENGTH: 425 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE:.
NAME/KEY: misc_feature LOCATION 1...425 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1693 1239 Arq Glu Gly Ala Met Asn Phe Phe Asp Thr Leu Met Gly Met Phe Val 1 Glu Pro Ser Gin Lys Val Ala L Phe Met Lys Asn Thr Leu Glu Val 145 Leu Glu Phe Ile Thr Trp Ile Asn Ile 130 Asn Thr Leu His Trp Ala Gly Phe Asp 115 Phe Leu Met Leu Ala Gin I Ala Tyr I Met Gly Ile Lys Tyr Pro 100 Gly Leu Ser Ile Trp Asp Ile Pro 165 Phe Leu 180 Phe Met Pro Gin Leu Thr Gly Ile 245 Thr Gin 260 Ile Ile Ile Ala Ser Val SAsn Ile 325 t Gin Lys 340 Ala Glu Ile ooo o oo 9 Gly Leu 225 Phe His Glu Asn Val 305 Phe Glu Gly Ala Leu 385 Val Gly Leu 210 Ile Asn Glu Gly Ser 290 Leu Ile Met 195 Ile Ser Tyr Val Lys 275 Tyr Gly Asr Met "eu .ys Val 70 Asn Ser Glu Gly Asn 150 Lys Gly Trp Thr Leu 230 Ile Gly Asp His Ile 31( Phe Il1 Va: Al G1 39 Ly Ile L 4 Arg V 55 Val V Pro A Glu L Ile I Asn I 135 Ala I Ile Leu Ser Lys 215 Tyr Tyr SPhe Val Ser 295 Cys e Gly e Gly 1 Ala a Gly 375 y Gly 0 s His ys eu 0 al al sn lys Pro 120 Leu Phe Ile Leu Ala 200 Gly Lys Lys Tyr Phe 28( Se Ph< Th Me As 36 Le Al Ser L 25 Asn T Lys G Phe I Asp P 9 Leu A 105 Thr A Ala S Asp G Met I Leu 185 Leu SMet Pro SVal Gly 265 SGly SIle e Phe r Ser t Thr 345 n Gin 0 u Gin a Ser 0 eu A hr I lu G le A 7 he I 0 la I sn ;er :ly Phe 170 Ile ly Leu Cys Asn 250 Asn Asn Val Leu Gly 330 Ile Val Ala Ala .la le !ly ila '5 Lsn Ile Thr 3er Ile 155 Phe Ile Leu Phe Met 235 Thr Ale Val Gly Va 31! Gli GlI Ly Gl Me Glu H Ile T 4 Asp M Phe V Thr I Leu I Asn I Ala 140 Asn Leu Val Ile Ser 220 SMet Leu Asp Leu y Phe 300 l.Lys 5 y Val y Gly s Gin y Ala 380 t Ala is V 3 hr I let P 'al G yr P :le jeu 125 Tyr Met /al Leu Val 205 Tyr Leu Ile Lys Lys 285 Leu Arg Gly Ala Ala 365 Lys Asn al 0 le 'he ;ly 'he Ala Ser Ala Phe Ile Leu 190 Leu Leu Val Pro Met 270 Gly Thr Val Al Va: 35 Ty Al Hi Gly S Leu P Glu P Phe I 8 Ile A Gin S Pro S Met Asn Leu 175 Val Pro SLys Ala Thr 255 Ala Asp SIle l Pro a Val 335 1 Phe 0 r Gin a Phe s Arg er he he le 0 sn er ;er Ile rrp 160 Sly Thr Leu Lys Phe 240 Lys Asn Trp Ile Asp 320 Thr Gly Ser Gly Ser Ser Ala Val Met Gly 370 Gly Lys Phe 355 Gly Ala Ala Asp Gly Ile Gly Asn 420 u r 1 395 400 Phe Val Ala Ser Val Lys Ser Gly Phe 415 Lys Asn Asn Lys 425 INFORMATION FOR SEQ ID NO:1694: SEQUENCE CHARACTERISTICS: LENGTH: 442 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein 1240 (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .442 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1694 Lvs Glu Gin Gin Met Ala Tyr Lys Pro Asn Lys Lys Lys Leu 1 S r Leu Ala Glu Ile Arg Gly Phe Asp Thr 145 Thr Ile Arg Ser Asn 225 Lys Glr Asi Ly Gi G 1 Le Ty Axg G Thr A 3 Pro L Ser Val I Glu I Glu I Arg 2 130 Asn His I Val Thr Ala 210 Asn Leu 1 Gin Asn s Leu 290 n Phe 5 r Ser u Ser r Glu ,sn 5 .eu Lrg ~yr :le rg sn 3er His Lys Lys 195 Glu Glt G11L Asn Pro Asp Lys Lys 100 Arg Arg Leu Asn Glu 180 Asp STyr L Asr 1 Phf Pro Tyr Pro Asp 85 Glu Ile Glu Lys Glu 165 Tyr I Gly Phe Thr Gl 241 x Sei n Ph u As e As e Gi 32 u Gi 0 1Ty lu Gin Pro Asn Le Val G1 Val Ve Ile G 70 Asn Si Ser S Thr L, Phe P1 1 Glu L 150 Thr H Asp H Gly L Lys L 2 Lys I 230 1 Leu I Ala 1 e Ala n His n Asn 4 310 n GluX
S
u Ile r Val 10 !u Phe Ser Ile Leu Asp L: 25 .u Giu Ser Asp Lys Ala A 40 4 1. Lys Thr Gin Ile Asn L Lu Trp Ala Lys Tyr Leu S 75 er Lys Giu Asp Val Asn P 90 er Arg Val Tyr Glu Ala A 105 ys Arg Tyr Asp Leu Ile 120 1 he Ile Lys Giu Ile Giu 1 35 140 eu Lys Glu Gin Gly Leu C 155 is Lys Lys Ala Leu Giu 2 170 is Leu Lys Asp Ile Tyr 185 eu Val Arg Giu Ile Ile 200 ,eu Tyr Asn Lys Leu Pro is 220 jeu Asn Thr Asn Asp Asn 235 la Lys Giu Val His Ile 250 Lhr Asn Tyr Tyr Sen Trp 265 rrp Lys Met His Arg Leu 280 Ueu Ser Ala Asn Asn Ala 295 300 Gly Ser Ile Leu Gly Trp 315 Asn Arg Asp Tyr Sen Leu 330 Ala Gin Ala Lys Ile Glu 345 Asn Gly Asp Gly Asn Lys 360 Arg Asp Thr Asn Asn Phe 375 380 Leu Val Sen Leu Ser Ala 395 ys G1 3) sn Lj ys A er P 'he P rsn L 1 ,sp A :le L ;iu I ksn G 31n C
I
Pro 1 205 Phe C Glu Leu Ile Ile 285 Asn Thr Arg Leu Arg 365 Glu ly la he he ys rg eu .le ly ;lu e lt As 27
AS~
Ly Ly Se G1 35 Gl
L],
Lys Glu Asp Vai Ile Gin Ser Met Glu Lys Ala Asn Glu Gly Asn Ile Thr His Gin Let 16( Asn G1 175 Val Gil Ile Se 1 Ser Ii i Val Ly 24 e Leu G1 255 p Lys As 0 n Giu As s Ile Ly s Glu GI 32 r Ala Le 335 .n Lys T) ;0 .u Ile L2 is Ala T r e s 0 u p n ss uu uu rn
I
Leu Ala 275 Lys Phe Ala Leu Ser Let 26( As: Gil Ph' Ii G1 34 Va 355 Pro Phe Lys Glu Ile Leu 370 Lys Giu Arg Tyr Asp Lys 385 390 Ala Ile Ile Gin 400 Ala Lys Asn Pro Glu Gly Gly Asn Glu Arg 405 Ile Lys Asn Thr Ile Clu 420 Gin Asn 410 Thr Asn 425 Sen Sen Thr Ser Ala Asn Asn Asn 415 Asn Asn Ile Ile 430
I
1241 Gin Asn Asn Asp Asn Ile Ile Ile Gin Ile 435 440 INFORMATION FOR SEQ ID NO:1695: SEQUENCE CHARACTERISTICS: LENGTH: 70 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...70 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1695 Ile Lys His Tyr Lys Gin Tyr Gly Thr Gly Leu His Leu Phe Arg His 1 5 10 Ser Phe Ala Thr Leu Ile Tyr Gin Glu Thr Gin Asp Leu Val Leu Thr 25 Ser Arg Ala Leu Gly His Ser Ser Leu Leu Ser Thr Lys Ile Tyr Ile 40 His Thr Thr Gin Glu His Asn Lys Lys Val Ala Leu Val Phe Asp Ser 50 55 Leu Ile Glu Asn Lys Lys e INFORMATION FOR SEQ ID NO:1696: SEQUENCE CHARACTERISTICS: LENGTH: 149 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION i...149 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1696 Lys Lys Arg Lys Tyr Met Arg Phe Arg Arg Val Lys Lys His Lys Asn 1 5 10 Lys His Asn Lys Glu His Thr Ser Met Asp Leu Gin Gin Ile Asp Glu 25 Leu Glu Lys Lys Phe Glu Glu Gin Glu Glu Gin Ala Gin Asp Thr Pro 40 Leu Lys Gin Glu Pro Ser Thr Lys Glu Val Lys Ile Pro Lys Lys Arg 55 Gly Arg Lys Lys Ser Leu Leu Asp Glu Asp Lys Lys Lys Ser Phe Asn 1242 Ile Giu Leu Leu Asn 145 70 75 Ala Phe Ser Pro Cys Val Ile Lys Giu Leu 90 Phe Gly Ser Phe Lys Giu Thr Arg Ser Thr 100 105 Ile Arg His Leu Lys His Arg Lys Asn Thr 115 120 Lys Gin Leu Giu Arg Leu Gin Asn Lys Giu 130 135 Asn Giu Leu Giu Asn Giu Phe Leu Leu Phe Ile Giu Giu Ala 110 Gin Giu Gin Lys Leu 125 Lys Gly Asn Asn Giu 140 INFORMATION FOR SEQ ID NO:1697: SEQUENCE CHARACTERISTICS: LENGTH: 373 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .373 ixi) SEQUENCE DESCRIPTION: SEQ ID NO:i697 *9*9 9* 4 Leu Asn Thr 1 Leu
LYS
Thr Ala His Gly Gin Lys Giu 145 Arg Pro Gly Sen Giu 225 Lys Gly Ser Lys Asn Sen Glu Gin 130 Leu Gin Asn Ala Arg 210 Gly Leu Ile Leu Pro Ile Gin 115 Ala Ala
LYS
LYS
Giu 195 Glu Lys Asp Tyr Lys Leu Leu Lys 100 Arg Leu Lys Phe Lys 180 Sen Asn Ile Lys Val Met Ala Leu Glu Leu Giu Asn Lys Met 165 Gin Phe Thr Leu Ile Ile Gdy Ser 70 Asp Asn Lys Leu Ile 150 Ala Leu Ile Tyn Ala 230 Met Arg Val1 55 Asp Thr Ser Ile Ile 135 Ly's Phe Gin Asp Lys 215 Phe Ile Ser 25 Leu Lys 40 Leu Leu Glu Asp Leu Thr Gly Trp 105 Phe Glu 120 Asn Lys Giu Ile Giu Met Thr Met 185 Asp Tnp 200 Ala Leu Gly Giu G iu Gly Gly Leu Ser 90 Asn Cys Giu Lys Lys 170 Leu His Gly Arg Asp 250 Ile Leu Ala Leu 75 Cys Leu Val Asp Giu 155 Glu Glu Giu Ile Ser 235 Ile Asn Thr Lys Asn Ser Glu Thr 140 Lys His Asn Arg Lys 220 Ile Thn Lys Tyr Leu Ile Ile Ile Lys Lys Ala Ang Ala Lys Giu 125 Lys Ala Ser Ala Phe 205 Glu Ile Asp Phe Thr Pro Val Lys Giu 110 Giu Asp Lys Lys Phe 190 Gly Tyn Ang Ile is Gin Leu Leu Lys Val1 Phe Lys Lys Val Glu 175 Asp Gly Ser Gin Phe Leu Lys Met Leu Asp Pro His Giu Leu 160 Phe Asn Ile Asp Tyr 240 Lys Lys Asp Phe Glu Glu Ser Thr Tyr 245' Thr Ang Gin Thn Leu Ser 1243 Ala Met Ala Asn Met Ser Gly Glu Asn Asp Tyr Lys Ile Thr Trp Leu 260 265 270 Lys Pro Lys Tyr Gin Leu His Ser Ser Asn Asn Ile Lys Pro Leu Met 275 280 285 Ser Asn Thr Glu Leu Leu Asn Met Ile Glu Leu Thr Asn Ile Lys Lys 290 295 300 Glu Tyr Val Met Gly Cys Asn Met Glu Ile Asp Gly Ser Lys Tyr Pro 305 310 315 320 Ile His Lys Asp Trp Gly Phe Phe Gly Lys Ala Lys Val Pro Glu Thr 325 330 335 Trp Arg Asn Lys Ile Trp Glu Cys Ile Lys Asn Lys Val Lys Ser Tyr 340 345 350 Asp Asn Thr Thr Ala Glu Ile Gly Ile Val Trp Lys Lys Asn Thr Tyr 355 360 365 Ser Ile Ser His His 370 INFORMATION FOR SEQ ID NO:1698: SEQUENCE CHARACTERISTICS: LENGTH: 231 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...231 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1698 Lys Asp Tyr Lys Thr Lys Lys Arg Ala Ile Met Lys Thr Met Asn Leu 1 5 10 Asn Glu Phe Phe Thr His Lys Ile Ile Tyr Lys Asp Thr Pro Leu Lys 25 Phe Lys Asp Thr Leu Glu Gin Glu Ile Ser Gin Ala Ser Leu Val Glu 40 Lys Leu Ile Leu Ala Asn Ile Leu Ala Asn Met Val Phe Ala Lys Ile 50 55 Ser Asn Glu Asn Ala Pro Lys Ile Leu Ile Ser Arg Leu Met Cys Lys 70 75 Phe Ser Pro Ile Asp Tyr Glu Ser Thr Ile Pro Ser Asp Phe Lys Pro 90 Ile Asp Glu Glu Glu Tyr Glu Asp Asp Leu Glu Trp Leu Asn Glu Glu 100 105 110 Lys Glu Asp Arg Leu Phe Asn Tyr Tyr Leu Phe Leu Asn Gly Ile Lys 115 120 125 Glu Ser Asp Val Glu Glu Val Phe Asn Glu Ser Val Glu Ile Tyr Asp 130 135 140 Glu Cys Leu Ile Glu Ile Ala Gin Asn Val Leu Lys Asp Lys Phe Ser 145 150 155 160 Tyr Asp Ile Asp Leu Leu Gin Val Leu Val Lys Gly Tyr Ala Lys Glu 165 170 175 Ile Arg Glu Phe Leu Ser Tyr Lys Pro lie Lys Glu Ile Lys Asp Phe 180 185 190 Lys Asp Lys Asp Thr Ala Leu Tyr Ile Ser Leu Gly Lys Asp Tyr Asp 195 200 205 Lys Glu Lys Glu Pro Phe Ser Lys Lys Leu Gin Gin Cys Phe Lys Glu
I
1244 220 210 215 Ile Leu Glu Ser Lys Gly Ile 225 230 INFORMATION FOR SEQ ID NO:1699: SEQUENCE CHARACTERISTICS: LENGTH: 421 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...421 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1699 a a.
a Met 1 Cys Pro Ser Asn Ile Asn Lys Tyr Asn 145 Gly Ile Ser Asn Gitl 225 Asr Va3 Lys Asj Lys Lys Glu Ile Gin Ser Ala Gin Leu 130 Lys Glu SSer SGly i Tyr 210 Gin Lys L Leu s Gin p Pro Gly Leu Thr Met Lys Lys Leu Val Phe c Ser Thr I Lys Leu Ser Gin Ser 115 Gin Ile Gin Gly Arg 195 Glu Lys Gin Gin Gly 275 Ile Tal 20 His Arg Gln Ser Tyr 100 Ile Gin Val Thr Ser 180 Ala Ser Arg Leu Thr 260 Ile Lys 5 Phe Val Tyr Lys Ala 85 Gin Glu Gin Asn Gin 165 Gly Trp Glu Arg Lys 245 SGlu SHis SAsn Ala Glu C Ser Gin Glu Glu 55 Val Asn 70 Ile Thr Ile Glu Asn Trp Cys Pro 135 Leu Lys 150 Thr Ala Tyr Gly Gly Glu Gin -Ala 215 Phe Leu 230 Asp Lys Phe Gly Tyr Cys Val Phe 295 ;ly Ala 40 lie Leu Ser Asn 120 Trp Asp Arg Asn Met 200 Leu Leu Leu Val Thr 280 Arg Glu 25 rhr Ile Met Ala Ile 105 Ala Leu Leu Asp Met 185 Leu Leu Arg Asp Thr 265 Glu Thi 10 Thr Ile Ser Ile Asn 90 Arg Gin Asn Asn Val 170 Gin Cys Ala Val Pro 250 Asp Asn SThr Pro Ile Lys Asn 75 Pro Tyr Asn Val Asn 155 Gin Ser Lys Thr Lys 235 Phe Pro Lys Arg Ser Leu Gly Ala Thr Met Asn Leu Asn 140 Leu Asn Leu Met Gly 220 Lys Let Thi Gl Lei Met I Ile Lys I Gin Thr Gin Tyr Leu 125 Ala Ile Leu SAla SVal 205 Asn SLys 1 Lys r Ala Thr 285 u Asp Leu ral let Ala Asn Val Glu 110 Arg Leu Thr Ile Gly 190 Asn Asn Val Arg Asn 270 Gly Asr Leu Asn Val Gin Ser Leu Asn Asn Thr Lys Gin 175 Glu Asp Pro Asn SLeu 255 SHis SLys 1 Glu Cys Asp Asp Val Leu Gin Leu Lys Asn Asn 160 Ser Leu Ser Glu Asp 240 Asp Asn Cys Leu 290 300 Glu 305 Gin Glu Ile Gin Thr Leu Thr Leu Asp 310 Leu Thr 315 Lys Ala Ser Lys Leu Leu Phe Lys 385 Phe Asp Leu Asn Arg 370 Gin Phe Ser Ala Thr Gin 355 Gin Leu Gin Ile Ala Leu Met Gly 375 Arg Val1 Tyr Lys Gin 360 Phe Ile Lys Ala Giu 345 Ser Gly Asn Phe 1245 ie Asn ir Asn .e Met rs Giu 380 -g Giu Ln Phe Gin Gin Thr 365 Asn Arg Gly Ile 335 Leu Asp Ile Arg Pro 415 4 INFORMATION FOR SEQ ID NO:i700: SEQUENCE CHARACTERISTICS: LENGTH: 446 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .446 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1700 Lys Arg Trp, Trp Tyr Phe Val Arg Ala Phe Leu Asn *4
S
1 Pro Ile Leu Tyr Met Ser Ile
LYS
Ile 145 Gly Asp Val Lys Leu Ile Ala s0 Ala Leu Ala Lys Lys 130 Val Leu Lau Ser Glu Leu Leu 35 Ser Asn Leu Asn Lys 115 Asn Gly Cys Giu Val 195 Val Asn 20 Lys Ala Ala
LYS
His 100 Phe Lau Pro Giu Ile 180 Ser Sen 5 Pro Lys Leu His Glu Cys Gin Giu Val 165 Leu Ala Ser Asn Gly Val Sen 70 Cys Val Giu Pro Glu 150 Val1 Glu Ala Leu Giu Val Glu 55 Val Gin Leu Ile Tyr 135 His Ang Gin Ser Cys 215 Asn.
Sen 40 Lys Ala Giu Sen Leu 120 Leu His Ile Thn Asn 200 Lys Leu Leu 25 Tyr Phe Arg Val Sen Lys Lys Leu 90 Aia Gly 105 Giy Val Lys Asp Sen Asn Pro Leu 170 Leu Lys 185 Val Thn Giu Tyr Asp Asp Lys His Lys Tyn Cys Met Glu 155 Asn Lys Gly Arg Gin Trp Sen Ala Ang Gly Ile Aia 140 Val1 Giu Thr Ile Ala Ang Val Gly Leu Ile Ser Ala Pro 125 Leu Ser His Pro Leu 205 Ile Sen Lys Ala Leu Leu Leu Ser 110 Sen Lys Trp Gly Asn 190 Thr Leu Phe Sen Ser Pro Met Asn Sen Lys Arg Arg Leu 175 Sen Pro Ala Ala Ser Gly Gly Leu Ala Thr Val Giu 160 Leu Leu Lau Leu 210 220 Asp Leu Ala Asn Phe* Sen Ala His Ala Asn Pro Lys Asp Cys Giu Tyn 1246 225 230 235 240 Gin Thr Gly Phe Tyr Ala Pro His Lys Leu Leu Gly Gly Val Gly Gly 245 250 255 Cys Gly Leu Leu Gly Ile Ser Lys Asp Leu Ile Asp Thr Gin Ile Pro 260 265 270 Pro Ser Phe Ser Ala Gly Gly Val Ile Lys Tyr Ala Asn Arg Thr Arg 275 280 285 His Giu Phe Ile Asp Giu Leu Pro Leu Arg Giu Glu Phe Gly Thr Pro 290 295 300 Gly Leu Leu Gin Phe Tyr Arg Ser Ala Leu Ala Tyr Gin Leu Arg Asp 305 310 315 320 Giu Cys Gly Leu Asp Phe Ile His Lys Lys Giu Asn Asn Leu Leu Arg 325 330 335 Val Leu Val Tyr Gly Leu Lys Asp Leu Pro Ala Ile Asn Ile Tyr Giy 340 345 350 Asn Leu Thr Ala Ser Arg Val Gly Val Val Ala Phe Asn Ile Gly Gly 355 360 365 Ile Ser Pro Tyr Asp Leu Ala Arg Val Leu Ser Tyr Giu Tyr Ala Ile 370 375 380 Giu Thr Arg Ala Gly Cys Ser Cys Ala Gly Pro Tyr Giy His Asp Leu 385 390 395 400 Leu Asn Leu Asn Ala Gin Lys Ser Ser Asp Phe Asn Ala Lys Pro Gly 405 410 415 Trp Leu Arg Val Ser Leu His ?he Thr His Ser Ile Asn Asp Ile Asp 420 425 430 Tyr Leu Leu Asp Ser Leu Lys Lys Ala Val Lys Lys Leu Arg 435 440 445 INFORMATION FOR SEQ ID NO:170i: SEQUENCE CHARACTERISTICS: LENGTH: 430 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein :0 (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori
FEATURE:
NAME/KEY: misc_feature LOCATION 430 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1701 Tyr Val Ile Glu Leu Asp Ile Asn Ala Ser Asp Lys Ser Leu Ser His 1 5 10 is Arg Ala Val Ile Phe Ser Leu Leu Ala Gin Lys Pro Cys Phe Val Arg 25 Asn Phe Leu Met Gly Giu Asp Cys Leu Ser Ser Leu Giu Ile Ala Gin 40 Asn Leu Gly Ala Lys Val Glu Asn Thr Ala Lys Asn Ser Phe Lys Ile 55 Thr Pro Pro Thr Thr Ile Lys Glu Pro Asn Lys Ile Leti Asn Cys Asn 70 75 Asn Ser Gly Thr Ser Met Arg Leu Tyr Sen Gly Let' Leu Ser Ala Gin 90 Lys Gly Leu Phe Val Leu Sen Gly Asp Asn Ser Leu Asn Ala Arg Pro 100 105 12:0 Met Lys Ag Ile Ile Giu Pro Leu Lys Ala Phe Gly Ala Lys Ile Leu 115 120 125 1247 Gly Arg Glu Asp Asn His Phe Ala Pro Leu Ala Ile Val Gly Gly Pro 130 135 140 Leu Lys Ala Cys Asp Tyr Glu Ser Pro Ile Ala Ser Ala Gln Val Lys 145 150 155 160 Ser Ala Phe Ile Leu Ser Ala Leu Gin Ala Gin Gly Ile Ser Ala Tyr 165 170 175 Lys Glu Ser Glu Leu Ser Arg Asn His Thr Glu Ile Met Leu Lys Ser 180 185 190 Leu Gly Ala Asn Ile Gin Asn Gin Asp Gly Val Leu Lys Ile Ser Pro 195 200 205 Leu Glu Lys Pro Leu Glu Ser Phe Asp Phe Thr Ile Ala Asn Asp Pro 210 215 220 Ser Ser Ala Phe Phe Leu Ala Leu Ala Cys Ala Ile Thr Pro Lys Ser 225 230 235 240 Arg Leu Leu Leu Lys Asn Val Leu Leu Asn Pro Thr Arg Ile Giu Ala 245 250 255 Phe Glu Val Leu Lys Lys Met Gly Ala His Ile Glu Tyr Val Ile Gin 260 265 270 Ser Lys Asp Leu Glu Val Ile Gly Asp Ile Tyr Ile Glu His Ala Pro 275 280 285 Leu Lys Ala Ile Ser Ile Asp Gin Asn Ile Ala Ser Leu Ile Asp Glu 290 295 300 Ile Pro Ala Leu Ser Ile Ala Met Leu Phe Ala Lys Gly Lys Ser Met 305 310 315 320 00*0 Val Arg Asn Ala Lys Asp Leu Arg Ala Lys Glu Ser Asp Arg Ile Lys 325 330 335 Ala Val Val Ser Asn Phe Lys Ala Leu Gly Ile Glu Cys Glu Glu Phe 340 345 350 Glu Asp Gly Phe Tyr Ile Glu Gly Leu Gly Asp Ala Ser Gin Leu Lys 355 360 365 Gin His Phe Ser Lys Ile Lys Pro Pro Ile Ile Lys Ser Phe Asn Asp 370 375 380 His Arg Ile Ala Met Ser Phe Ala Val Leu Thr Leu Ala Leu Pro Leu 385 390 395 400 Glu Ile Asp Asn Leu Glu Cys Ala Asn Ile Ser Phe Pro Thr Phe Gin 405 410 415 Leu Trp Leu Asn Leu Phe Lys Lys Arg Ser Leu Asn Gly Asn 420 425 430 INFORMATION FOR SEQ ID NO:1702: SEQUENCE CHARACTERISTICS: LENGTH: 192 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...192 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1702 Asn Ala Arg Thr Phe Leu Ser Gin Pro Phe Ser Phe Gly Ser Ile Tyr 1 5 10 Ser Lys Lys Gly Val Ser Met Glu Ile Lys Met Ala Lys Asp Tyr Gly 25 Phe Cys Phe Gly Val Lys Arg Ala Ile Gin Ile Ala Glu Lys Asn Gin
I
1248 40 Asn Ser Leu Ile Phe Gly Ser Leu Ile His Asn Ala Lys Glu Ile Asn 55 Arg Leu Glu Lys Asn Phe Asn Val Lys Ile Glu Glu Asp Pro Lys Lys 70 75 Ile Pro Lys Asn Lys Ser Val Ile Ile Arg Thr His Gly Ile Pro Lys 90 Gin Asp Leu Glu Tyr Leu Lys Asn Lys Gly Val Lys Ile Thr Asp Ala 100 105 110 Thr Cys Pro Tyr Val Ile Lys Pro Gin Gin Ile Val Glu Ser Met Ser 115 120 125 Lys Glu Gly Tyr Gin Ile Val Leu Phe Gly Asp Ile Asn His Pro Glu 130 135 140 Val Lys Gly Val Ile Ser Tyr Ala Thr Asn Gin Ala Leu Val Val Asn 145 150 155 160 Ser Leu Glu Glu Leu Gin Glu Lys Lys Leu Gin Arg Lys Val Ala Leu 165 170 175 Val Ser Gin Thr Thr Lys Gin Thr Pro Lys Leu Leu Gin Ile Ala Ser 180 185 190 INFORMATION FOR SEQ ID NO:1703: SEQUENCE CHARACTERISTICS: LENGTH: 87 amino acids S. TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein S(iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...87 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1703 S Lys Leu Pro Ile His Ala Phe Val Leu Met Cys Leu Ala Ile Pro Ser 1 5 10 Lys Val Ile Ala Ile Asn Asp Asn Val Ala Leu Leu Glu Thr Leu Gly S: 20 25 Val Gin Arg Glu Ala Ser Leu Asp Leu Met Gly Glu Ser Val Lys Val 40 Gly Asp Tyr Val Leu Leu His Ile Gly Tyr Val Met Ser Lys Ile Asp 55 Glu Lys Glu Ala Leu Glu Ser Ile Glu Leu Tyr Gin Glu Met Ile Ala 70 75 Glu Val Asn Glu Thr His Glu INFORMATION FOR SEQ ID NO:1704: SEQUENCE CHARACTERISTICS: LENGTH: 246 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
1249 (vi) ORIGINAL SOURCE: ORGAN~ISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc -feature LOCATION .246 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1704 a. a, a a a.
a. a a a a, a a a a Lys 1 Pro Lys dly Thr Val Lys Glu Ala Val1 145 Leu Phe Val Lys Leu 225 Gin Asn Asn Ser Met Glu Gly Ala Leu 130 Cys Sen Met Phe Pro 210 Giu Ser Leu Asp Val Leu Gly Val Ser Giu Pro Val Cys Asn 195 Glu Asp Thr 5 Ser Lys Ile Lys Cys Val Glu Asn Asp Leu Sen Ala 100 Met Ile Lys Ser Sen Ser Pro Giu 165 Ala Asp 180 Phe Ang Ala Pro Phe Lys His Sen 245 Lys Ala Asn Leu 70 Gin His Glu Asp 150 Gly Ala Val Ile Asn 230 Phe Asp Ala Phe 55 Ala Thr Gin Gly Phe 135 Asn Asp Val Ser Phe 215 Ile Glu 40 Met Asp As n Ile Ala 120 Leu Leu Asp Ile Gin 200 Leu Lys 25 Met Sen Phe Arg Thr 105 Phe Ile Gly Lys Ile 185 Val Met Ile Lys Sen Lys Asp 90 Thr Asp Ile Aia Val 170 Ser Lys Sen Val Giu Pro Asp 75 Ala Giy Leu Giu Ala 155 Leu Lys Giu Ser Lys 235 Giu Arg Gly Phe Asp Giu Leu Asn 140 Met Lys Ala Asp Lys 220 Lys Tyr Ser Lys Arg Ala Lys 125 Val1 As n Tyrn Asp Met 205 Asp Ile Leu Gly Phe Leu Cys 110 Asp Giy Ile Pro Met 190 Gin Pro Leu Lys Lys Cys Arg His Giu Asn Val Thr 175 Ile Lys Lys Ser Glu Thn Val Lys Leu Gly Leu Leu 160 Met Giu Leu Sen Tyr 240 Gly Thr Ser Met Ser Giu Gin Arg Lys Glu Ser Leu Gin Asn Asn Phe Leu Leu Giu Lys Arg Glu Asn INFORMATION FOR SEQ ID NO:1705: ()SEQUENCE CHARACTERISTICS: LENGTH: 957 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 957 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1705 Giy Lys Ile Met Ala.Lys Lys Lys Gin Glu Val Arg Asn Asn Giu Ile 1250 Phe Asn Glu Leu Ala Lys Cys Thr Ser 145 Phe Va1 Asp Leu Val Phe Lys Va1 Gly 130 Val Ser Ala Pro Leu Ala Tyr Leu Arg 115 Ser Ala Ala Glr Leu Asp Tyr Gin Asn 100 Phe Gly Met Asn 1 Lys Leu Ala Giu Giu Giu Leu Asn Ala Asn Glu Ile a.
6*Sa a a.
S. S
S
*r a S. a. Lys Leu Leu Asp 225 Asn Thr Phe Thr Gly 305 Glu Ala Phe Asn Asn 385 Glu Lys Phe Glu Asn 465 Tyr Asn Arg 180 I Lys Ser Val 195 Met Lys Glu 210 Glu Giu Ser Gly Giu Asn Glu Ser Lys 260 Leu Phe Asn 275 Ala Val Tyr 290 Lys Giu Ser Leu Lys Asp Leu Leu Leu 340 His Asp Pro 355 Ser Asp Ala 370 Asp Asp Glu Leu Lys Asn Asp Tyr Lys 420 Lys Gly Leu 435 Val Ile Ile I 450 Thr Ser Asp I Glu Met Leu Tyr Gin Gin 55 Phe Arg Asp 70 Lys His Tyr His Leu Leu Glu Asn Phe Lys Thr Ile 135 Gly Met Gly 150 Glu His Leu 165 Asn Lys Asp Lys Asn Lys Ile Ala Leu 215 Lys Glu Asn 230 Tyr Val Ile 245 Arg Gin Ala Phe Ser Ala Asn Leu Ser 295 Vai Leu Leu I 310 Leu Asn Asp 1 325 Leu Gly Met C Leu Met Leu 1 3 Glu Ile Phe P 375 Ser Asp Phe S 390 Pro Glu Phe L 405 Ile Giu V'l P *ys Glu Ala V 4 ksn Pro Lys A 455 .is Val Phe C 470 ;luLys Leu L 185 1u Glu Ser 7 40
GI
Ph Se Ly Ii 12 Va Le' Il
TY:
Asy 201 Phe Let Lei I l rhr 280 lal trg ;In ral 60 'he er .eu he al 40 sn ys
YS
rr .n Aia e Lys r Phe s Ser 105 e Asn 0 1 Ile u Ile e Lys Ser 185 P Phe Tyr a Leu I Asp Phe 265 Phe Gly Lys Glu I Lys 1 345 Phe '9 Lys 'I Lys P Phe S 4 Lys G 425 Phe Asn G Leu I Ser V 4 Phe S 505 Asp Phe Lys Se Leu Glu Ala 90 His Arg Ile Pro Gin 170 Lys Tyr Tyr Asn Glu 250 Ser rhr Glu ksnI *ys C 330 rg rhr H 'hr L li L 3 er A 10 lu S 'r A in G ie A 4 al L 90 er G Il Se 75 As Ph Le Ly Ly 15 Ph GIi Arc Ar Tya 235 Ala Leu Glu rrp ~sn 15 ;lu yr is ,eu ,ys 95 .sp er .la lu rg 75 ys !r Phe .e Asn r Lys n Cys e Lys u Ala s Leu 140 s Lys
S
Glu Ile g Ala I Ala 220 Lys His Leu Glu Val 300 Leu I Ile I Lys Ser 'l 3 Ala A 380 Asp A Gly L Leu L Ser A 4 Ile A 460 Ile G Val V Asp Ala Lys Asp Val Phe 125 Va1 Asn Lys Asp Pro 205 Asp Asp I Lys Ser 3er 285 .ys I ~sn I la I ral c 3 al 1 xg V sp L .ys A ys G 4 sn G la P ly A al S As Ph G1 Ph G1 11 Ty G1 Ii G11 Gi Ph 19' Ly Le Cy.
Le; 270 ksp eu kla ~eu ;lu r50 LSn ral eu sp ly ly he sp er ;p Asn le Arg .u Phe .e Ala u Asn 0 r Met u Leu e Met u Ile 175 e Lys 0 s Asp a Met Trp.
r Asn 255 Lys Leu Gly Phe I Leu I 335 Gly 3 Met G Ile G Leu G 4 Lys 0 415 Met A His I Lys L Ile T 4' Lys K 495 Lys Val Tyr Lys His Ala Leu Phe 160 Glu Asn Ser Ser Asp 240 Lys ly lie ryr .ys 120 lyr llu lu lu 00 lu pp le eu hr sn 0*4 oa a S. Glu Trp Ile Arg c 4 Leu Ser Phe Lys C in Ile Asp Ile 500 Lys Se Se 510 Asn Ile 515 Leu Val Gly Ser Arg 520 Ala Phe Asp Thr Gly Trp Asp Ser 525 1251 Thr Arg Pro Ser Val Ile Leu Phe Leu Asn 530 Ala Lys 545 Ser Val Ala Ile Phe Val Gin Lys 610 Ile Lys 625 Tyr Arg Phe Lys Leu Met Lys Asp 690 Lys Val 705 Ile Lys Asn Ala Lys Ala Giu His 770 Gly Giu 785 Phe Lys Thr Pro Lys Val Giu Thr 850 Glu His 865 Arg Arg Gin Ile Giu His Pro Lys .930 Giy Asp 945 Lys Lys Lys Ile 595 Glu Leu Lys Met Ser 675 Ser dly Leu Asp 755 Ala Ile Val Leu Lys 835 Leu Leu Phe Ile Lys 915 Asp Lys Leu Asn Asp 580 Pro Ser Glu Giu Ser 660 Giu Ala Thr Lys Asp 740 Lys Pro Asp Gly Ile 820 Ser Gin Asp Phe Cys 900 Ala Asp Asp Gin Gin Lys His Gly 615 Arg Asn Asn Phe .Lys 695 Tyr Pro Lys Lys Lys 775 Asp Giu
LYS
Asp Tyr 855 Phe Phe Asp Tyr Leu 935 Gly Ser Arg Pro Ala 600 Gly l1i6 Ala Phe Ile 680 Giu Lys Asn Ile Leu 760 Glu Thr Leu Asn Phe 840 Asp Ile Ile Pro Gin 920 Lys Glu 535 Ile Arg 555 Tyr Ala Giu Arg Ala 635 Ile Leu His Gin Asp 715 Val1 Phe Thr Arg His 795 Leu Trp Glu Ala Ile 875 Leu Ser Glu Val Arg 955 Leu Val1 Giu Leu Ile 605 Pro Phe Gin Giu Ile 685 Ala Met Lys Arg Gin 765 Lys Gin Glu Lys Leu 845 Ser Asn Lys His Lys 925 Leu Leu Asp Ile Asp 575 Met Lys Arg Pro Ala 655 Phe Asp Phe Ser Giu 735 Lys Val1 Ala Arg Tyr 815 Val Ile Ile Thr Gly 895 Asp Phe Phe INFORMATION FOR SEQ ID NO:l706: SEQUENCE CHARACTERISTICS: LENGTH: 249 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein 1252 (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .249 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1706 Cys Ile Ang Val Glu Giu Thr Val Leu Arg 145 Met Gin Gly Val Ser 225 His Lys Ser Ala Leu Pro Phe Asn 120 Ile Ala Leu Ile Giy 200 Ser Phe Lys Gly Ala Gin Lys Leu Ile 105 Leu Giy His Gly Val 185 Leu Vai Leu Asn Met Arg Phe Tyr Phe Lys Phe Leu Trp Ser Lys Asn Leu Giu Asn Giu Ile Lys Phe 170 Pro Asp Giu Ser Leu Leu Ser Ser Asn Ser Ile Lys Giu Asn Asn Pro Leu Giu Glu Asn Ala Val 140 Arg Cys 155 Ile Gly Ser Aia Gly Ile Asp. His 220 Giu Ala 235 Gly Leu Giu Ala Lys Asp Lys 125 Leu Ala Thr Giu Phe 205 Tyr Lys Ile Phe Ile Ser Leu Asp Phe Gin Asp Leu Met Thr Thr His 110 Ile Tyr Giu Lys Tyr Ser Asn Phe 175 Ile As n 190 Gly Ala Thr Tyr Leu Leu
INFORMATION
Wi SEQUEN( FOR SEQ ID NO:i707: :E CHARACTERISTICS: LENGTH: 154 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL. YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .154 (Xi) SEQUENCE DESCRIPTION: SEQ ID NO;1707 1253 Trp Tyr Phe Lys Lys Glu Arg Asn Pro Met Val Ile His Glu Lys Ile 1 5 10 Lys Ser Arg Phe Ser Arg Asn Trp Ser Leu Arg Asn Arg Gly Arg His 25 Phe Ala Ser Ser Ser Val Tyr Phe Phe Ser Leu Leu Val Ile Thr Ala 40 Val Asn Arg Ser Ser Ala Val Ala Trp Leu Leu Met Pro Glu His Leu 55 Ile Gly Trp Phe Leu Ile Ser Phe Ser Gly Glu Phe Val Ala Asp Met 70 75 Ala Phe Gly Lys Lys Ser Lys Ile Phe Lys Thr Arg Phe Gly Ile Ser 90 Ile Val Ser Gly Val Ser Leu Leu Leu Gly Ala Leu Pro Ala His Leu 100 105 110 Phe Phe Val Trp Phe Gly Phe Ile Asn Trp Trp Ala Val Phe Phe Ile 115 120 125 Glu Ala Gly Ala Asp Leu Leu Val Gly Cys Val Ile Gin Lys Ile Phe 130 135 140 Phe Gly Lys Tyr Trp Val Asp Arg Tyr Tyr 145 150 INFORMATION FOR SEQ ID NO:1708: SEQUENCE CHARACTERISTICS: LENGTH: 76 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: S(A) ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...76 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1708 Trp Ala Lys Gly Ala Gly Ala Leu Val Leu Glu Glu Tyr Glu Ser Ala 1 5 10 Lys Lys Arg Gly Ala Lys Ile Tyr Ala Glu Phe Ala Gly Tyr Gly Glu 25 Ser Gly Asp Ala Asn His Ile Thr Ala Pro Ala Pro Glu Gly Glu Arg 40 Ala Phe Lys Ala Met Lys Met Ala Leu Glu Met Ala Lys Val Glu Val 55 Cys Tyr Val Asn Ala His Gly Asp Lys His Ala Leu 70 INFORMATION FOR SEQ ID NO:1709: SEQUENCE CHARACTERISTICS: LENGTH: 111 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES 1254 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .111 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1709 Thr Pro Met Gly Thr Ser Thr His Tyr Asn Asp Trp Tyr Giu Ser Ile 1 5 10 Ala Leu Lys Asn Val Phe Gly Ser Lys Giu Lys Val Pro Pro Val Ser 25 Ser Thr Lys Gly Gin Ile Giy His Cys Leu Gly Ala Ala Gly Ala Leu 40 Val Ala Val Ile Ser Ile Met Ala Met Asn Gin Gly Ile Leu Pro Pro 55 Thr Ile Asn Gin Giu Thr Pro Asp Pro Giu Cys Asp Leu Asp Tyr Ile 70 75 Pro Asn Thr Ala Arg Giu Lys Gin Val Asn Ala Val Met Ser Asn Sen 90 Phe Gly Phe Gly Gly Thr Asn Gly Val Val Ile Phe Lys Lys Ala 100 105 110 INFORMATION FOR SEQ ID NO:i710: SEQUENCE CHiARA~CTERISTICS: LENGTH: 189 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc...feature LOCATION .189 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:17i0 Gly Pro Ile Gin Ser Ala Pro Ala Met Asn Lys Leu Phe Leu Ala Phe 1 5 10 le Val Gly Gly Met Leu Leu Ser Ala Asp Ala Leu Asn Asp Lys Ile 25 Giu Asn Leu Met Gly Giu Arg Ser Tyr His Met Asn Lys Leu Phe Leu 40 Giu Arg Leu Phe Lys Asn-Arg Lys Asp Phe Tyr Giu Met Gly Ang Leu so 55 Asp Ser Leu Lys Leu Leu Asn Thr Leu Lys Giu Asn Gly Leu Leu Sen 70 75 Phe Asn Phe Asp Lys Pro Sen Val Leu Lys Ile Thr Phe Lys Ala Sen 90 Ser Asn Pro Leu Ala Phe Ala Lys Sen Ile Asn Asn Sen Leu Asn Met 100 105 110 Met Gly Tyr Ser Tyr Val Leu Pro Ile Arg Met Gin Ser Ser Sen Gly 115 120 125 Giu Asn Val Phe Ser Tyr Glu Leu Lys Thn Glu Tyr Val Leu Asp Pro 130 135 140 As Ile Leu Ile Giu Thr Met Lys Ang His Gly Phe Asp Phe Met Asp 145 :150 155 160 1255 Ile Arg Arg Val Ser Leu Lys Glu Trp Glu Tyr Asp Phe Ala Leu Gin 165 170 175 Lys Ile Lys Leu Pro Asn Gly Glu Ser Leu Ser Phe Glu 180 185 INFORMATION FOR SEQ ID NO:i711: SEQUENCE CHARACTERISTICS: LENGTH: 321 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .321 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1711 Met Gin Leu Ala le Phe Val Giu
LYS
LYS
145 Val Giu Ser Pro Ala 225 le
LYS
Leu Giu *Giu *Asn Lys Giu 50 Leu Ile
LYS
Gin Val 130 Lys Ile Giu Phe Lys 210 Ile Trp Val Leu Gin 290 Gin Asn Lys 5 Ile Ser Lys 20 Asn Leu Asp 35 Ile Cys Lys Glu Lys Arg Gin Ile Leu 85 Giu Phe Asp 100 Lys Gin Giu 115 Giu Leu Asp Ser Ser Lys Ile Leu Val 165 Arg Giu Gin 180 Asn Giu Thr 195 Leu Giu Giu Lys Glu Asn Val Glu Val 245 Phe Lys LYS 260 Arg Phe Giy 275 Asp Tyr Asn Lys Asp Lys Ala Tyr 70 Glu Lys Thr Trp 150 Val Glu Asn Lys Pro 230 Ile Sen His Asp Ser Leu Glu Asn Ile Asn Thr 55 Giu His Val1 Sen Ser 135 Lys Val Arg Pro iffis 215 Asn Asp Tyr Gly Sen 295 Sen Leu 40 Lys Ser G iu Cys Pro 120 Ile Pro Ile Ala Thr 200 Lys Thr Leu Pro His 280 Lys Gly 25 Gin Ile Leu Tyr Val 105 Giu Asn Phe Ile Ile 185 Giu Giu Ile Asp Leu 265 Leu Thr 10 Thr Ile Ala Ser Lys 90 Phe Giu Gin Vai Gin 170 Lys Giu Gin Giu 250 Glu Ile Arg Leu Ala Leu Sen Ang 75 Ile Lys, Thr Ala Ile 155 Asn Pro
LYS
Asp Ile 235
LYS
Ala Leu Arg Asp Leu Leu Giu Lys Giu Lys Asn Val His Asp Leu Giu Gly Ala Lys 125 Asm. Thr 140 Val Leu Sen Sen Asp Thr Lys Leu 205 Lys Gin 220 le Pro Lys Asn Lys Asn Lys Asn.
285 Phe Leu 300 Tyr Lys Ser Giu Val Ile Ala Ser Vai 110
LYS
Ser Gly Ser Lys 190 Giu Giy Lys Ser His 270 Asn Tyr Ala Asp Val Leu Ser Gly Ala His Sen Arg Gly Ala Trp Giy Giu Pro Leu Leu Ser Val Val 160 Leu Lys 175 Asn Asn Pro Thr Lys Giu Arg Asp 240 Phe Gin 255 Arg Leu His Gin Glu Pro Leu Gin Asn Lys Gly Leu Thr.Leu Ile Asn Glu Ala Gin 1256 305 310 315 320 Gin INFORMATION FOR SEQ ID NO:1712: SEQUENCE CHARACTERISTICS: LENGTH: 115 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...115 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1712 Arg Ser Gly Asn Thr Thr Leu Pro Tyr Lys Arg Ser Ser Ser Leu Thr 1 5 10 Ala Arg Ala Leu Val Leu Ser Ser Asp Pro Val Glu Phe Lys Glu Ala 20 25 Ser Gly Lys Tyr Trp Leu Ser Val Asn Gin Asn Ala Tyr Leu Lys Ile 40 Ser Ser Asn Asn Pro Leu Trp Gin Pro Lys Ile Ile Phe Tyr Asp Glu 55 Asn Leu Lys Ile Ile Gin Ile Ile Ala Lys Glu Asn Arg Gln Gln Glu 70 75 SIle Ala Leu Asn Leu Leu Asp Gly Val Arg Phe Ile His Ile Thr Asp 85 90 Ala Lys Asn Pro Ile Ile Leu Lys Asn Gly Ile Ser Val Val Phe Asp 100 105 110 Ala Met Pro 115 INFORMATION FOR SEQ ID NO:1713: SEQUENCE CHARACTERISTICS: LENGTH: 205 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...205 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1713 Arg Ser Leu Ala Cys Trp Leu Arg Leu Ser Leu Phe Lys Gly Ile Ile 1 5 10
I
1257 Met Phe Asp Ser Ile Val Tyr Phe Phe Asn Lys Ser Gly Phe Val Thr 25 Thr Leu Val Leu Val Trp Ile Ser Leu Tyr Leu Val Met Thr Leu Trp 40 Val Phe Leu Tyr Lys Ser Ile Val Leu Lys Ile Giu Leu Arg Arg Giu 55 Met Gin Ser Leu Ser Asn Ile Leu Asn Gly Ala Gin Asp Ala Gin Ser 165 70 75 Ile Leu Cys Leu Ile Lys Lys Glu Met Met Arg Pro Lys Gly Ile Leu 90 Met Asn Cys Cys Arg Aia Trp Lys His Gin Val Leu Lys Gin Ser Thr 100 105 110 Thr Gly Leu Val Val Leu Ser Ile Ile Ser Ser Thr Ala Pro Phe Ile 115 120 125 Giy Lau Phe Gly Thr Val Vai Glu Ile Leu Giu Ala Phe Asn Asn Leu 130 135 140 Gly Ala Leu Gly Gin Ala Ser Phe Gly Vai Ile Ala Pro Ile Ile Ser 145 150 155 160 Lys Ala Leu Ile Ala Thr Ala Ala Gly Ile Leu Ala Ala Ile Pro Ala 165 170 175 Tyr Ser Phe Tyr Leu Ile Leu Lys Arg Lys Val Tyr Asp Leu Ser Val 180 185 190 Tyr Val Gin Met Gin Val Asp Ile Leu Ser Ser Lys Lys 195 200 205 INFORMATION FOR SEQ ID NO:1714: SEUENCE CHARACTERISTICS: LENGTH: 136 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES .9 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni' (ix) FETUE NAME/KEY: misc_ feature LOCATION 1 .136 SEQUENCE DESCRIPTION: SEQ ID NO:1714 Lys Val Phe Met Asn Tyr Asp Asn Tyr Trp, Asp Giu Asp Lys Pro Giu 1 5 10 Leu Asn Ile Thr Pro Leu Val Asp Val Met Leu Val Leu Leu Ala Ile 25 Leu Met Val Thr Thr Pro Thr Leu Thr Tyr Lys Giu Glu Ile Ala Leu 40 Pro Sen Gly Ser Lys Thr Ala Arg Ala Thr Gin Asp Lys Val Ile Giu 55 le Arg Met Asp Lys Asp Ala Lys Ile Tyr Ile Asp Ser Gin Thr Tyr 70 75 Giu Tyr Asn Sen Phe Pro Asp Thr Phe Asn Leu Leu Ser Lys Lys Tyr 90 Asp Lys Asp Thr Arg Val Sen Ile Arg Ala Asp Lys Arg Leu Thn Tyr 100 105 110 Asp Lys Val Ile Tyr Leu Leu Lys Th Ile Lys Giu Ala Gly Phe Leu 115 120 125 Lys Val Ser Leu Ile Thr Sen Pro 130 135 1258 INFORMATION FOR SEQ ID NO:1715: SEQUENCE CHARACTERISTICS: LENGTH: 128 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...128 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1715 Lys Val Gly Pro Ile Cys Met Ser Lys Ser Ala Ile Phe Val Leu Ser 1 5 10 Gly Phe Leu Ala Phe Leu Leu Tyr Ala Leu Leu Leu Tyr Gly Leu Leu 25 Leu Glu Arg His Asn Lys Glu Ala Glu Lys Ile Leu Leu Asp Leu Asn 35 40 Lys Lys Asp Glu Gin Ala Ile Asp Leu Asn Leu Glu Asp Leu Pro Ser 50 55 Glu Lys Lys Asn Glu Lys Ile Glu Lys Val Thr Glu Lys Gin Gly Asp 65 70 75 Phe Leu Glu Pro Lys Glu Glu Pro Lys Glu Glu Pro Glu Glu Ser Leu 85 90 Glu Asp Ile Phe Ser Ser Leu Asn Asp Phe Gin Glu Arg Gin Thr Lys 100 105 110 Thr Leu Lys Lys Thr Ser Lys Lys Met Asn Lys Lys Asn Lys Gly Val 115 120 125 INFORMATION FOR SEQ ID NO:1716: SEQUENCE CHARACTERISTICS: LENGTH: 215 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...215 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1716 Gly Arg Thr Met Lys Tyr Leu Trp Leu Phe Leu Ile Tyr Ala Ile Gly 1 5 10 Leu Phe Ala Thr Asp Lys Thr Leu Asp Ile Ile Lys Thr Ile Gin Lys 25 Leu Pro Lys Ile Glu Val Arg Tyr Ser Ile Asp Asn Asp Ala Asn Tyr 40 1259 Ala Leu Lys Leu His Glu Val Leu Ala Asn Asp Leu Lys Thr Ser Gin 55 His Phe Asp Val Ser Gin Asn Lys Glu Gin Gly Ala Ile Asn Tyr Ala 70 75 Glu Leu Lys Asp Lys Lys Val His Leu Val Ala Leu Val Ser Val Ala 90 Val Glu Asn Gly Asn Lys Ile Ser Arg Leu Lys Leu Tyr Asp Val Asp 100 105 110 Thr Gly Thr Leu Lys Lys Thr Phe Asp Tyr Pro Ile Val Ser Leu Asp 115 120 125 Leu Tyr Pro Phe Ala Ala His Asn Met Ala Ile Val Val Asn Asp Tyr 130 135 140 Leu Lys Ala Pro Ser Ile Ala Trp Met Lys Arg Leu Ile Val Phe Ser 145 150 155 160 Lys Tyr Ile Gly Pro Gly Ile Thr Asn Ile Ala Leu Ala Asp Tyr Thr 165 170 175 Met Arg Tyr Gin Lys Glu Ile Ile Lys Asn Asn Arg Leu Asn Ile Phe 180 185 190 Pro Lys Trp Ala Asn Ala Glu Gin Thr Glu Phe Tyr Tyr Thr Gin Met 195 200 205 Ala Glu Lys Arg Pro Trp Phe 210 215 INFORMATION FOR SEQ ID NO:1717: SEQUENCE CHARACTERISTICS: LENGTH: 114 amino acids S(B) TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: 0 ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...114 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1717 Phe Leu Arg Gly Lys Phe Ile Gin Glu Arg Leu Lys Ala Leu Cys Cys 1 5 10 Gin Gly Val Glu Gly Glu Phe Gly Val Leu Tyr Gly His Ser Asn Met 25 Ile Thr Leu Leu Gin Ala Gly Val Val Glu Ile Glu Thr Glu Asn Gin 40 Lys Glu His Ile Ala Ile Asn Trp Gly Tyr Ala Glu Val Thr Asn Glu -55 Arg Val Asp Ile Leu Ala Asp Gly Ala Val Phe Ile Lys Lys Gly Ser 70 75 Asp Asp Arg Asp Asp Ala Ile Ser Arg Ala Lys Lys Leu Leu Glu Asp 90 Ala Ser Ser Asp Arg Leu Ala Val Ser Ser Val Leu Ala Lys Ile Glu 100 105 110 Ser Leu INFORMATION FOR SEQ ID NO:1718: SEQUENCE CHARACTERISTICS: 1260 LENGTH: 99 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...99 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1718 Lys Leu Ser Met Arg Ala Ile Ala Ile Val Leu Ala 1 5 Lys Arg Ile Lys Asn Lys Asn Met Ile Asp Phe Phe 25 Leu Ala Tyr Pro Ile Glu Thr Ala Leu Asn Ser Lys 40 Val Phe Ile Ser Ser Asp Ser Met Glu Tyr Val Asn 55 Tyr Gly Ala Ser Phe Leu Asn Leu Arg Pro Lys Asn 65 70 Gln Gly His Asp Phe Arg Ser Asp Gly Leu Ser His 85 Ile Lys Arg INFORMATION FOR SEQ ID NO:1719: SEQUENCE CHARACTERISTICS: LENGTH: 256 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...256 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1719 Ile Pro Pro Ser Thr Pro Phe Leu Asn Ile Leu His 1 5 Tyr Arg Ser His Tyr Gly Lys Ile Asn Thr Cys Leu 25 Asp Leu Ile Leu Ala Leu Pro Val Tyr Tyr Asp Lys 40 Gly Val Ile Gin Ser Leu Gln Val Gly Ile Ile Gly 55 Gly Glu Ala Gin Ala Leu Asn Leu Arg Asp Ser Lys 70 Ile Gly Leu Tyr Gin Gly Ser Leu Ser Val Ser Lys Arg Asn Leu Leu Leu Glu Val Asn Asp Tyr Val Ala Ser Lys Phe Ala Ala Arg Phe Thr Ile Gly Lys Lys 1261 Gly Phe Glu Val Leu Gly Val Lys Glu Leu Val Gin Gin Ser Asp Val 100 105 110 Ile Met Ala Leu Leu Pro Asp Glu Leu His Lys Glu Val Leu Glu Lys 115 120 125 Glu Val Ile Pro Phe Leu Lys Glu Gly Gin Ile Ile Gly Phe Ala His 130 135 140 Gly Phe Ser Val His Phe Asn Gin Val Val Leu Pro Lys Gly Val Gly 145 150 155 160 Ala Ile Leu Val Ala Pro Lys Gly Pro Gly Ser Ala Leu Arg Glu Glu 165 170 175 Tyr Leu Lys Asn Arg Gly Leu Tyr His Leu Ile Ala Ile Glu Gin Glu 180 185 190 Ser Ser Ile His Asn Ala Lys Ala Val Ala Leu Ser Tyr Ala Lys Ala 195 200 205 Met Gly Gly Gly Arg Met Gly Val Leu Glu Thr Ser Phe Lys Glu Glu 210 215 220 Cys Glu Ser Asp Leu Phe Gly Glu Gin Ala Val Leu Cys Gly Gly Leu 225 230 235 240 Glu Ala Ile Val Arg Met Gly Phe Glu Thr Leu Ile Lys Ala Gly Tyr 245 250 255 INFORMATION FOR SEQ ID NO:1720: S(i) SEQUENCE CHARACTERISTICS: LENGTH: 91 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...91 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1720 Gin Thr Ser Arg Ala Thr Thr Leu Glu Val Met Ala Tyr His Met Lys 1 5 10 Glu Leu Glu Leu Lys Asp Glu Asp Ile Ala Cys Cys Leu Tyr Gly Val 25 Ser Val Phe Leu Gin Glu Lys His Leu Gin Asn Ala Phe Glu Thr Leu 40 Lys Gin Asn Gin Asn Thr Asp Tyr Val Phe Thr Cys Ser Pro Phe Ser 55 Ala Ser Pro Ile Val Leu Leu Ala Leu Lys Thr Ala Phe Lys Trp Leu 70 75 Leu Lys Ser Ile Gin Thr Arg Ala Arg Lys Ile INFORMATION FOR SEQ ID NO:1721: SEQUENCE CHARACTERISTICS: LENGTH: 312 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein 1262 (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .312 (Xi) SEQUENCE DESCRIPTION: SEQ ID NO:172.
Met 1 Leu Tyr Phe Gly Ala Val1 Giu Ser Lys 145 Asn Pro Leu Asn Arg 225 Arg Gin Leu Ile Pro 305 Lys Leu Gin Lys Lys Val Ser Ala Glu 130 Ile Ala Ser Val Pro 210 Leu Asp Asn Gin Cys 290 Cys Gln Cys Ile Thr Val1 Val Tyr 115 Lys Val1 Leu G1y Ile 195 rhr Asp Hiis A.sn Asp 275 Pro Asn Lys Ile Pro Pro Sen Lys 100 Leu Arg Phe Leu Leu 180 Thn Lys Ala Ala Ala 260 Cys Lys Ile Leu Thr Ile Ile G ly Asn Ala Leu Asp 150 Pro Arg Asp Met Leu 230 Phe Ser Leu Leu Glu 310 Pro Ala Ile Ang Lys Lys Ala Leu 140 As n Tyr Tyn Ile Ile 220 Lys Glu Lys Asp 300 Phe Lys Ala Tyr Gly Thr Sen 125 Glu Phe Pro Lys Thr 205 Ala Lys Lys Asp Leu 285 Ile Se r Lys Gly Gin Leu Ala 110 Val1 Leu As n Phe Glu 190 Ser Asn Leu Glu Leu 270 Lys Leu Leu His Gly G iu Val1 Gly Ile G ly Gin Cys 175 Ala Ile Pro Tyr Phe 255 Val Leu Ser Ser Asp Lys Pro Phe Leu Giu Arg Tyr Phe Tyr Asp Pro Thr INFORMATION FOR SEQ ID NO:1722: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 197 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) (vi) HYPOTHETICAL: YES ORIGINAL SOURCE: 1263 ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...197 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1722 Lys Val Leu Trp Val Leu Tyr Phe Leu Thr Ser Leu Phe Ile Cys Ser 1 5 10 Leu Ile Val Leu Trp Ser Lys Lys Ser Met Leu Phe Val Asp Asn Ala 25 Asn Lys Ile Gin Gly Phe His His Ala Arg Thr Pro Arg Ala Gly Gly 40 Leu Gly Ile Phe Leu Ser Phe Ala Leu Ala Cys Tyr Leu Glu Pro Phe 55 Glu Met Pro Phe Lys Gly Pro Phe Val Phe Leu Gly Leu Ser Leu Val 70 75 Phe Leu Ser Gly Phe Leu Glu Asp Ile Asn Leu Ser Leu Ser Pro Lys 90 Ile Arg Leu Ile Leu Gin Ala Val Gly Val Val Cys Ile Ile Ser Ser 100 105 110 Thr Pro Leu Val Val Ser Asp Phe Ser Pro Leu Phe Ser Leu Pro Tyr 115 120 125 Phe Ile Ala Phe Leu Phe Ala Ile Phe Met Leu Val Gly Ile Ser Asn 130 135 140 S* Ala Ile Asn Ile Ile Asp Gly Phe Asn Gly Leu Ala Ser Gly Ile Cys 145 150 155 160 Ala Ile Ala Leu Leu Val Ile His Tyr Ile Asp Pro Ser Ser Leu Ser 165 170 175 Cys Leu Leu Ala Tyr Met Val Leu Gly Phe Met Val Leu Asn Phe Pro 180 185 190 l Ser Gly Lys Ile Phe 195 *a INFORMATION FOR SEQ ID NO:1723: SEQUENCE CHARACTERISTICS: LENGTH: 163 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1..-.163 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1723 Gin Phe Val Leu Phe Ala Arg Leu His Gly Ala Trp Val Tyr Gly Val 1 5 10 Lys Phe Pro Phe Arg Lys Asp Phe Leu Gly Asp Gly Gly Ala Tyr Phe 25 Leu Gly Leu Val Cys Gly Ile Ser Leu Leu His Leu Ser Leu Glu Gin 40 Lys Ile Ser Val Phe Phe Gly Leu Asn Leu Met Leu Tyr Pro Val Ile 55 Glu Val Leu Phe Ser Ile Leu Arg Arg Lys Ile Lys Arg Gin Lys Ala 1264 70 75 Thr Met Pro Asp Asn Leu His Leu His Thr Leu Leu Phe Lys Phe Leu 90 Gin Gin Arg Ser Phe Asn Tyr Pro Asn Pro Leu Cys Ala Phe Ile Leu 100 105 110 Ile Leu Cys Asn Leu Pro Phe Ile Leu Ile Ser Val Leu Phe Arg Leu 115 120 125 Asp Ala Tyr Ala Leu Ile Val Ile Ser Leu Val Phe Ile Ala Cys Tyr 130 135 140 Leu Ile Gly Tyr Ala Tyr Leu Asn Arg Gin Val Cys Ala Leu Glu Lys 145 150 155 160 Arg Ala Phe INFORMATION FOR SEQ ID NO:1724: SEQUENCE CHARACTERISTICS: LENGTH: 90 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...90 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1724 Met Asn Lys Thr Ile Lys Ala Ala Ala Leu Ala Tyr Asn Met Gly Gin 1 5 10 Asp His Ala Pro Lys Val Ile Ala Ser Gly Val Gly Glu Val Ala Lys 25 Arg Ile Ile Gin Lys Ala Lys Glu Tyr Asp Ile Ala Leu Phe Ser Asn 35 40 Pro Met Leu Val Asp Ser Leu Leu Lys Val Glu Leu Asp Cys Ala Ile 55 Pro Glu Glu Leu Tyr Glu Ser Val Val Gin Val Phe Leu Trp Leu Asn i: 65 70 75 Ser Val Glu Asn Asn Ala Gin Met Ser Lys INFORMATION FOR SEQ ID NO:1725: SEQUENCE CHARACTERISTICS: LENGTH: 285 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature
I
1265 LOCATION .285 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i725 Val1 1 Ile Lys Ser Giu Leu Leu Ile Leu Leu 145 Asn Ser Lys Lys Giu 225 Thr Gin Ile Lys Lys Ser Asn Asn Met Vai Vai Giu Leu Lys Asn Ile Giu Tyr Lys Thr Vai Gin Leu Ala Giu 130 Ser Cys Lys Phe Giu 210 Arg Lys Asp Ile Giu Giy Leu Leu Lys Ser Arg 115 Leu Gly Pro Thr Asp 195 Leu Giy Giu Ile Ser 275 Asn Asp Ile Val1 Aia Aia 100 Trp Vali Gly Asn Thr 180 Leu Cys Ser Leu Tyr 260 Asn Gly Ile Arg As n Arg Lys Giu Gly Gin Leu 165 His Ser Asn Vai Leu 245 Arg Leu Phe Leu Leu Giy 70 Gin Asn Lys Leu Lys i50 Leu Ser Ile Gin Giu 230 Gly Ile Ile His Gly Ile Val1 Lys Val Thr Giu 135 Gin Leu Ile Val Met 215 Giu Ile Vai Arg Ala Val1 40 Asn Asn Ile Phe Lys 120 Asp Arg Cys Leu Phe 200 Cys Ile Lys Phe Arg 280 Leu 25 Ile Cys Leu Gly Giu 105 Ile Lys Val1 Asp Thr 185 Ile Val Phe Asn Leu 265 Phe Asn Gly Pro Lys Gin Phe Val1 125 Tyr Arg Ser Gly Ile 205 Gly Lys Asp Leu Arg 285 Leu Aia Ser Pro His Ala 110 His Pro Ser Ala Ile 190 Giu Giu His Gin Asp 270 Glu Gly Ser Lys Phe Leu Giu Lys Leu Leu 175 Gin Val Ile Ala Lys 255 Glu Lys Leu Lys Gly Giu Asn Glu Leu Gin Ala 160 Asp Lys Val1 Val1 Val1 240 Ser Pro INFORMATION FOR SEQ ID NO:1726: fi) SEQUENCE CHARACTERISTICS: LENGTH: 147 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .147 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1726 Leu Phe Cys Ser Cys Leu Tyr Gin Arg Phe Leu Ile Gly Thr Ser Ile 10 Gly Ser Sen Ala Ser 'lie Ile Pro Leu Ala Ile Sen Ala Ile Pro Phe 1266 Val Ile Met Thr Ala Arg Gin Asn 145 Glu Ser Ser Ile Asp Phe Ala Asn Leu Leu Gly Leu Tyr Gly 135 Ser Gly Pro Tyr Ala Ala 120 Asp Val1 Leu As n Ala Gly Ile Lys 140 Glu Glu Asn dly Tyr Ile 125 Arg 0
,P*
V000.
a INFORMATION FOR SEQ ID NO:1727: SEQUENCE CHARACTERISTICS: LENGTH: 279 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .279 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1727 Ser Tyr Phe Cys Tyr Asn Leu Arg Leu Leu Ser Leu e 1 Thr Gin Thr Ala Asp Met Ala Thr Leu 145 Glu Thr Leu Arg His Ile 35 Phe Lys Gin Tyr Met Giu Ser Gin 100 Thr Gly 115 Tyr Thr Thr Sen Thr Thn Cly Leu 180 Leu Thr Sen Gly 70 Gly Ser Gly Ser Gly 150 Val Thr Tyr Thr Arg Thr Leu Pro Phe Gly 135 Tyr Asn Thr Ser Sen 40 Ala Asn Gly Lys Phe 120 Asn Leu Ile Ser Gly 200 Ala 25 Asn Asp Thr Val Glu 105 Gin Phe Leu Gly Asn 185 Sen Ile Asn Asn 75 Pro Glu Gin Leu Pro 155 Asp Ile Val1 Met Asn Leu Thr Ala Asn Pro 125 Glu Ile Thr Gin Gly 205 Lys Gly Lys Leu Ala Gin Val Asn Thn Phe Tyr Gin Leu Sen Pro Ile Thr Lys Leu Asp Ile 110 Asp Gly Thr Gin Gly Asn Thr Leu Pro 160 Val Ser Val 175 Ile Thr Leu 190 Asp Asn Leu Ala Asn Phe Val Asn.Pro Ala Leu His Ser Met 1267 Phe Ser Ile Thr Asn Ala Ser Gly Asp Ala Ile Val Gly Asn Pro Asp 210 215 220 Ser Gln Gly Leu Gly Lys Leu Arg Gin Gly Phe Leu Glu Leu Ser Asn 225 230 235 240 Val Arg Leu Val Glu Glu Met Thr Asp Leu Ile Thr Ala Gin Arg Ala 245 250 255 Tyr Glu Ala Asn Ser Lys Ser Ile Gin Thr Ala Asp Ala Met Leu Gin 260 265 270 Thr Val Asn Ser Leu Lys Arg 275 INFORMATION FOR SEQ ID NO:1728: SEQUENCE CHARACTERISTICS: LENGTH: 316 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...316 SEQUENCE DESCRIPTION: SEQ ID NO:1728 Lys Trp Arg Asn Ser Ser Ser Asp Lys Met Ala Lys Lys Lys Ile Ala 1 5 10 Ile Ser Cys Gly Asp Ile Gin Gly Val Gly Leu Glu Leu Ile Leu Lys 20 25 Ser His Lys Glu Val Ser Ala Leu Cys Glu Pro Leu Tyr Leu Val His 40 Ser Glu Leu Leu Glu Arg Ala Asn Gln Leu Led Asp Asn Ala Tyr Glu 55 Thr Lys Thr Leu Asn Ala Ile Ala Ile Asp Ala Pro Leu Pro Leu Leu 70 75 Asn Ser Ser Thr Ile Gly Lys Val Ser Thr Gin Ser Gly Ala Tyr Ser 90 Phe Glu Ser Phe Lys Lys Ala Cys Glu Leu Ala Asp Ser Lys Glu Val 100 105 110 Asp Gly Ile Cys Thr Leu Pro Ile Asn Lys Leu Ala Trp Gin Gin Ala 115 120 125 Gin Ile Pro Phe Val Gly His Thr Asp Phe Leu Lys Gin Arg Tyr Lys 130 135 140 Asp His Gin Ile Ile Met Met Leu Gly Cys Ser Lys Leu Phe Val Gly 145 150 155 160 Leu Phe Ser Asp His Val Pro Leu Ser Ala Val Ser Gin Leu Ile Gin 165 170 175 Val Lys Ala Leu Val Lys Phe Leu Leu Ala Phe Gin Lys Ser Thr Gin 180 185 190 Ala Lys Ile Val Gin Val Cys Gly Phe Asn Pro His Ala Gly Glu Glu 195 200 205 Gly Leu Phe Gly Glu Glu Asp Glu Lys Ile Leu Lys Ala Ile Gin Glu 210 215 220 Ser Asn Gin Thr Leu Gly Phe Glu Cys Phe Leu Gly Pro Leu Pro Ala 225 230 235 240 Asp Ser Ala Phe Ala Pro Asn Lys Arg Lys Ile Thr Pro Phe Tyr Val 245 250 255 Ser Met Ser His Asp Val Gly Leu Ala Pro Leu Lys Ala Leu Tyr Phe 1268 260 265 270 Asp Glu Ser Ile Asn Val Ser Leu Asn Ala Pro Ile Leu Arg Ala Ser 275 280 285 Thr Asp His Gly Thr Ala Phe Asp Ile Ala Tyr Gin Asn Lys Ala Asn 290 295 300 His Lys Ser Tyr Leu Asn Ala Ile Lys Tyr Leu Ala 305 310 315 INFORMATION FOR SEQ ID NO:1729: SEQUENCE CHARACTERISTICS: LENGTH: 354 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...354 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1729 S" Gln Gly Ile Ile Gln Ala Lys Thr Pro Pro Lys Asp Lys Asp Met Ile 1 5 10 Leu Ser Ile Glu Ser Ser Cys Asp Asp Ser Ser Leu Ala Leu Thr Arg S 20 25 Ile Glu Asp Ala Lys Leu Ile Ala His Phe Lys Ile Ser Gin Glu Lys 40 His His Ser Ser Tyr Gly Gly Val Val Pro Glu Ile Ala Ser Arg Leu 50 55 His Ala Glu Asn Leu Pro Leu Leu Leu Glu Arg Val Lys Ile Ser Leu 70 75 Asn Lys Asp Phe Ser Lys Ile Lys Ala Ile Ala Ile Thr Asn Gin Pro 85 90 e. Gly Leu Ser Val Thr Leu Ile Glu Gly Leu Met Met Ala Lys Ala Leu 100 105 110 Ser Leu Ser Leu Asn Leu Pro Leu Ile Leu Glu Asp His Leu Arg Gly 115 120 125 His Val Tyr Ser Leu Phe Ile Asn Glu Lys Gin Thr Arg Met Pro Leu 130 135 140 Ser Val Leu Leu Val Ser Gly Gly His Ser Leu Ile Leu Glu Ala Arg 145 150 155 160 Asp Tyr Glu Asp Ile Lys Ile Val Ala Thr Ser Leu Asp Asp Ser Phe 165 170 175 Gly Glu Ser Phe Asp Lys Val Ser Lys Met Leu Asp Leu Gly Tyr Pro 180 185 190 Gly Gly Pro Ile Val Glu Lys Leu Ala Leu Asp Tyr Ala His Pro Asn 195 200 205 Glu Pro Leu Met Phe Pro Ile Pro Leu Lys Asu Ser Pro Asn Leu Ala 210 215 220 Phe Ser Phe Ser Gly Leu Lys Asn Ala Val Arg Leu Glu Val Glu Lys 225 230 235 240 Asn Ala His Asn Leu Asn Asp Glu Val Lys Gin Lys Ile Gly Tyr His 245 250 255 Phe Gin Ser Ala Ala Ile Glu His Leu Ile Gln Gln Thr Lys Arg Tyr 260 265 270 Phe Lys Ile Lys Arg Pro Lys Ile Phe Gly Ile Val Gly Gly Ala Ser 275 280 2R> 1269 Gin Asn Leu Ala Leu Arg Lys Ala Phe Glu Asp Leu Cys Ala Glu Phe 290 295 300 Asp Cys Giu Leu Val Leu Ala Pro Leu Glu Phe Cys Ser Asp Asn Ala 305 310 315 320 Ala Met Ile Gly Ar; Ser Ser Leu Giu Ala Tyr Gln Lys Lys Arg Phe 325 330 335 Ile Pro Leu Glu Lys Ala Asp Ile Ser Pro Arg Thr Leu Leu Lys Asn 340 345 350 Phe Giu INFORMATION FOR SEQ ID NO:1730: SEQUENCE CHARACTERISTICS: LENGTH: 256 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein HYPOTHETICAL: YES ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni to 00(ix)
FEATURE:
NAM~EfKEY: misc feature LOCATION 1. 256 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1730 As; Asn Asn Met Ala Tyr Lys Tyr Asp Arg Asp Leu Giu Phe Leu Lys 1 5 10 Gin Leu Glu Sen Ser Asp Leu Leu Asp Leu Phe Giu Val Leu Val Phe 25 dy Lys As p Gly Glu Lys Ang His Asn Glu Lys Leu Thr Sen Sen Ile 40 Giu Tyr Lys Ar; His Gly Asp Asp Tyr Ala Ly Tyr Ala Giu Ar; Ile sola5 55 AaGlu Giu Leu Gin Tyr Tyr Gly Ser Asn 5cr Phe Ala Sen Phe Ile 70 75 Lys Gly Giu Gly Val Leu Tyr Lys Giu Ile Leu Cys Asp Vai Cys Asp 90 Lys Leu Lys Val Asn Tyr Asn Lys Lys Thn Glu Thn Thr Leu Ile Giu 100 105 110 Gin Asn Met Leu Ser Lys Ile Leu Glu As; Sen Leu Glu Glu Met Asp 115 120 125 Asp Giu Glu Vai Lys Glu Met Cys Asp Glu Leu Sen Ile Lys Asri Thr 130 135 140 Asp Asn Leu Asn Ar; Gin Ala Leu Sen Ala Ala Thn Leu Thr Leu Phe 145 iSO 155 160 Lys Met Gly Gly Phe Lys Sen Tyr Gin Leu Ala Val Ile Val Ala Asn 165 170 175 Ala Val Ala Lys Th Ile Leu Gly Ar; Gly Leu Sen Leu Ala Gly Asn 180 185 190 Gin Val Leu Thn As; Thr Leu Ser Phe Leu Thr Gly Pro Val Gly Trp 195 200 205 Ile Ile Thn Gly Val Tnp Thr Ala Ile Asp Ile Ala Gly Pro Ala Tyr 210 215 220 An; Val Thr Ile Pro Ala Cys Ile Val Val Ala Thr Leu Ar; Leu Lys 225 230 235 240 Thr Gin Gin Ala Asn Glu Asp Lys Lys Ser Leu Gin Ile Glu Sen Val 245 250 255 1270 INFORMATION FOR SEQ ID NO:1731: SEQUENCE CHARACTERISTICS: LENGTH: 101 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...101 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1731 Val Ile Ile Phe Leu Leu LeU Phe Phe Leu Gly Asn 1 5 10 Ile Tyr Leu Leu Leu Glu Ser Phe Leu Trp Val Ile 20 25 Cys Cys Leu Val Met His Glu Asp Gin Arg Gin Lys 40 Leu Ile Asn Gly Ile Asp Arg Ile Ile Lys Ala Asn 55 Leu His Gin Glu Thr Gin Gin Ala Asn Lys Thr Asp 70 Leu Ala Ala Asn Val Phe Leu Ile Gly Leu Val Val 90 His Met Ile Lys Arg 100 Lys Val Phe Leu Thr Thr Asp Met Glu Ser Gly Lys Lys Ala Trp Leu Ala Val *u INFORMATION FOR SEQ ID NO:1732: SEQUENCE CHARACTERISTICS: LENGTH: 118 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...118 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1732 Ala Val Lys Lys Val Glu Ser Met Asn Val Val Pro Phe Ile Asp Ile 1 5 10 Met Leu Val Leu Leu Val Ile Val Leu Thr Thr Ala Ser Phe Val Gin 25 Thr Ser Lys Leu Pro Ile Ser Ile Pro Gin Val Asp Lys Asp Ser Thr 40 Asp Ser Lys Asp Val Leu Asp Lys Lys Gin Val Thr Ile Ala Ile Ser 55 1271 Asn Lys Gly Ser Phe Tyr Phe Asp Asp Lys Glu Ile Ser Phe Glu Asn 70 75 Leu Lys His Lys Val Ser Thr Leu Ala Lys Asp Thr Pro Ile Val Leu 90 Gin Gly Asp Lys Lys Ser Asn Leu Asp Asn Phe Ile Lys Val Val Asp 100 105 110 Leu Leu Gin Leu Thr Ile 115 INFORMATION FOR SEQ ID NO:1733: SEQUENCE CHARACTERISTICS: LENGTH: 112 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES *o (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...112 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1733 S Leu His Arg Gin Ala Gln Val Arg Ile Ser Leu Thr Gin Thr Thr Thr 1 5 10 Leu Val Ala Thr Ile Gly Ser Asn Ala Pro Tyr Ile Gly Leu Leu Gly 25 Thr Val Met Gly Ile Met Leu Thr Phe Met Asp Leu Gly Ser Ala Ser 35 40 Gly Ile Asp Thr Lys Ala Ile Met Thr Asn Leu Ala Leu Ala Leu Lys 55 Ala Thr Gly Met Gly Leu Leu Val Ala Ile Pro Ala Ile Val Ile Tyr 70 75 Asn Leu Leu Val Arg Lys Se r Glu Ile Leu Val Thr Lys Trp Asp Ile 90 Phe His His Pro Val Asp Thr Gin Ser His Glu Val Tyr Ser Lys Ala 100 105 110 INFORMATION FOR SEQ ID NO:1734: SEQUENCE CHARACTERISTICS: LENGTH: 139 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...139 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1734 1272 Asn His 1 Ile Trp Leu Val Leu Lys Val Phe Ty~r Trp Ser Lys Thr Leu Ala Arg 130 Lys Met Val1 Gin Phe Ala Leu Gin 115 Phe le His Ser Giy Ile Cys Gly 100 Pro Asp Arg Sh Phe Vai Pro Val Ala Ser Gin Gly Asp Leu T'yr Phe 70 Ile Gin Giu Asn Tyr Leu Leu Tyr 55 Arg Leu Arg Pro Gin 135 Glu Leu Ile 40 Ala Lys Leu Trp Val1 120 Pro Lys Pro 25 Phe Ile Leu Ala Leu 105 Lys Thr Arg Met 10 Phe Val Giu Ser Gly Phe Asp Arg Leu Val 90 Vai Ile Ile Ala Ser Phe Ala Phe Ser Leu Trp Asp Pro Ile Leu Ile Ala Leu Leu Phe Phe Leu 125 Asp Ile Val1 Phe Phe Met Thr 110 Leu Lys Pro Leu Trp Ala Gly Ser Leu a INFORMATION FOR SEQ ID NO:1735: SEQUENCE CHARACTERISTICS: LENGTH: 310 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .310 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1735 1Phe Cys Gly Thr Leu Lys Ala Leu Lys Ile Lys Ile Thr Cys Lys Leu Asn Asp Phe Ser Asp His 145 Met
LYS
Lys Gly s0 Ile Ala
LYS
Phe Glu 130 Phe Ile Ala Lys Phe Pro Phe Gly Arg Thr Leu Glu Leu Pro Lys Thr Val Phe 100 Gly Lys Ser Glu Lys Leu Arg Ile Gin Val Leu Lys le Cys 165 Lys Lys Met Trp Giu Arg 55 Val Val 70 Giu Thr Arg Ala Lys Val Cys Leu 135 Gin Arg i50 Lys Thr Trp Arg 40 Glu Phe Lys Tyr Pro 120 Ser Val Ile Lys 25 Ile Leu Thr Gly Vai 105 Val Asp Lys Ile Ile Leu Cys Ala Leu Ser His Thr 75 Ile Ile 90 Arg Val Giu Gly Ala Giu Ile Gin 155 His Val Leu Lys Leu Arg Phe Ala Gin Ala Asp Giu Asn Ser Leu Giu 125 Lys Asn 140 Giu Arg Ala Ser Thr Thr Pro is His Leu Met Arg Leu Leu Lys His Trp Giu Ala Gly Giu Trp Gly Val Aia*Phe 110 Giu Leu Val Lys Lys Arg Lys Gin Ala 160 Gly Ala Ala 175 170 Gly Val Ala Gly Leu Ile Pro Ile Pro Phe Ser Asp Ala Leu Ala Ile 185 190 1273 Ala Pro Ile Gin Ala Gly Met Ile Tyr Lys Met Asn Asp Ala Phe Gly 195 200 205 Met Asp Leu Asp Lys Ser Val Gly Ala Ser Leu Val Ala Gly Leu Leu 210 215 220 Gly Val Thr Ala Val Ala Gin Val Gly Arg Thr Leu Val Asn Gly Phe 225 230 235 240 Leu Lys Phe Ile Pro Val Val Gly Ser Val Ala Gly Gly Ala Thr Ala 245 250 255 Ala Val Ile Thr Glu Gly Ile Gly Phe Ala Tyr Leu Lys Val Leu Glu 260 265 270 Lys Cys Phe Asn Asp Glu Thr Gly Glu Val Asn Leu Pro Gly Glu Val 275 280 285 Gly Met Ile Thr Ser Leu Phe Lys Glu Asn Tyr Leu Asn Leu Asp Thr 290 295 300 Ile Lys Lys Leu Lys Pro 305 310 INFORMA.TION FOR SEQ ID NO:1736: 00. 0 SEQUENCE CHARACTERISTICS: LENGTH: 419 amino ac-ids TYPE: amino acid o~o TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
9 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni
FEATURE:
NAME/KEY: misc feature LOCATION 1 .419 *9~9 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1736 Met Arg Sen Trp Met Lys Lys Lys Tyr Phe Thr Leu Leu Leu Gin Ser 1 5 10 Sen Val Val Leu Ala Val Phe Ile Gly Cys Ser Ser Thr Ang Asn His 25 Thr Phe Sen Ala Leu Ser Asn Gin Giu Asn Thr Asp Asp Lys Leu Pro 40 Val Val His Ser Ile Lys Thr Ile Asn Asp Val Ser Sen Val Gly Phe s0 55 Glu Trp Sen Lys Val Ala Asp Thr Tyr Asp Ile Asp Gly Phe Val Leu 70 75 Tyr Arg Leu Lys Lys Asp Sen Lys Leu Lys Arg Ile Ala Thr Ile Lys 90 Asn Pro Tyr Ala Thr His Tyr Tyr Asp Giu Gly Leu Glu Thr Giu Ser 100 105 110 Sen Tyr Thr Tyr Gin Leu Ala Thr Tyr Lys Gly Asp Lys Ile Sen Lys 115 120 125 Leu Sen Glu Pro Ile Leu Val Lys Thr Ser Phe Ile Asn Pro Val Glu 130 135 140 Ser Val Phe Ala Ser Leu Glu Tyr Pro Lys Sen Val Lys Val Phe Trp, 145 150 155 160 Ser Pro His Pro Asn Pro Sen Val Ser Lys Tyr Ile Ile Gin Arg Gin 165 170 175 Asn Lys Asp Gly Lys Phe Leu Asn Val Gly Ala Val Lys Asn Arg Leu 180 185 190 Phe Val Glu Phe Phe Asp Lys Asp Leu Giu Asp Gly Gin Lys Tyr Ang 195 200 205 Tyr Gin Ile Ile Ala Glu Asn Phe Met Giy Asp Lys Ser Ang Pro Ser 1274 210 215 220 Val Ile Val Giu Gly Lys Thr Lys Asp Leu Pro Lys Giu Ile Ala Asn 225 230 235 240 Val Arg Val Ser Gin Asn Leu Thr Arg Gin Ile Giu Leu Ser Trp Asp 245 250 255 Lys Ser Pro Giu Giu Asp Val Ile Ala Tyr Arg Ile TIyr Ala Ser Asn 260 265 270 Asn krg Asn Asp Lys Tyr Lys Phe Ile Ala Gin Thr Thr Asn Thr Ser 275 280 285 Tyr Val Asp Lys Ile Giu Lys Asp Asn Leu Thr Arg Tyr Tyr Lys Val 290 295 300 Val Ala Val Asp Lys Thr His Leu Giu Gly Ala Leu Pro Lys Giu Pro 305 310 315 320 Ala Met Gly Giu Thr Ser Asp Arg Pro Giu Ala Pro Ile Ile Thr Lys 325 330 335 Gly Thr Ile Gin Asp Ser Ser Ala Leu Ile Gin Trp Glu Asn Asn Pro 340 345 350 Ser Pro Lys Ile Ala Thr Tyr Ala Vai Tyr Arg Phe Glu Ala Asn Ser 355 360 365 Lys Thr Pro Leu Arg Phe Gly Asn Ile Thr Gin Asn Gin Phe Val Asp 370 375 380 Lys Asp Met Lys Val Gly Val Ala Tyr Arg Tyr Gin Val Val Ser Val 385 390 395 400 *Asp Lys Asp Gly Leu Giu Ser His Pro Ser Lys Giu Val Arg Leu Phe 405 410 415 Leu Giu Arg INFORMATION FOR SEQ ID NO:i737: SEQUENCE CHARACTERISTICS: LENGTH: 260 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. .260 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1737 Leu Lys Asn Thr Leu Lys Gly Leu Leu Met Leu Asp Phe Asp Leu Val 1 5 10 Leu Phe Gly Ala Thr Giy-Asp Leu Ala Met Arg Lys Leu Phe Val Ser 25 Leu Tyr Glu Ile Tyr Ile His Tyr Gly Phe Lys Asn Asp Sen Ag Ile 40 Ile Ala Sen Gly Arg Lys Glu Leu Sen Asn Giu Giu Phe Leu Ala Leu 55 Leu Cys Giu Lys Thr Gin Leu His Ser Ang Glu Lys Gly Giu Giu Phe 70 75 Leu Thr His Ile Ser Tyr Leu Arg Val Ang Leu Asp Asn Pro Lys Asp 90 Phe Giu Glu Leu Ser Lys Ile Ala Thn Asn Asn Lys Pro Leu le Phe 100 10S 110 Tyr Phe Ser Ile Ser Pro Ser Phe Phe Ala Thr Thn Aia Gin Asn Leu 115 120 125 Ala Pro 145 Ser dly Ile Tyr Gly 225 Leu Lys Gin 130 Leu Ala Lys Leu Giu 210 Ala Ile Ser Asn Ala Gly His Phe Phe Lys Gly 180 Asn Ile 195 Thr Leu Leu Arg Ala Thr Lys Phe 260 Leu Asp Lys 165 Val Leu Gly Asp Asp 245 Asn Leu 150 Giu Gin Trp Val Met 230 Leu His 135 Lys Giu Asn Asp Giu 215 Val1 Pro Ala Thr Gin Ile Gin 200 Giu Gin Asn Asn Cys Ile Leu 185 Ile Arg Asn Asp Thr Lys Phe 170 Giu Ser Gly His Leu 250 1275 Arg Leu 140 Giu Ile 155 Arg Ile Leu Arg Ala Val Giu Phe 220 Leu Leu 235 Lys Asp Ile Leu Phe Gin Asp His Leu Asn 190 Glu Ile 20 Tyr Asp Gin Val Leu Arg Giu Ser Tyr 175 Asn Cys Lys Leu Gin 255 *fl.
*s a.
INFORMATION FOR SEQ ID NO:i738: SEQUENCE CHARACTERISTICS: LENGTH: 346 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyiori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .346 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1738 Gly Met Vai Lys His Tyr Leu Phe Met Ala Val Ser Gin Val Phe Phe a Ser Ser Val Pro Lys Leu Tyr Ala 145 Lys Ser Phe Ile Gin s0 Ile Asp Met Leu Giy 130 Gly Thr Leu Leu Thr Ala 70 Leu Phe Leu Gin Gin 150 Ser Ser Phe Leu Ser 55 Ala Val Val Ile Lys 135 Lys Phe Phe Val 40 Leu Cys Phe Pro Leu 120 Lys Leu Asp Ile Ser 25 Ile Lys Pro Gly Ala Leu Phe Ser Leu Ser 105 Ile Pro Asp Lys Gly Asp Asn Leu 170 Leu Ala Ser Ile Vai Val Ser Phe Thr Thr Phe Gly Leu Ser Leu Gly Val Leu Leu Val Thr Ser Lys 125 Ile Asp Ile 140 Trp Leu Val 155 Val Leu Phe Gin Lys Gly Leu Leu Phe Arg Ser Ser 110 Ser Asn Ser Asn 190 His 180 Asn Gin Asn Gly Val Phe Giu Leu Asn Leu Tyr Asn Gly 1276 195 200 205 Phe Thr Gin Gly Asp Lys Met Arg Lys Val Asp Phe Glu Glu Leu His 210 215 220 Leu Arg Asn Lys Leu Lys Ser Phe Asn Ser Asn Asp Ala Ala Tyr Leu 225 230 235 240 Gin Gly Thr Asp Tyr Leu Gly Tyr Trp Lys Lys Ala Phe Gly Lys Asn 245 250 255 Ala Asn Lys Asn Gin Lys Arg Arg Phe Ser Gin Ala Ile Leu Val Ser 260 265 270 Leu Phe Pro Leu Ala Ser Val Phe Leu Ile Pro Leu Phe Gly Ile Ala 275 280 285 Asn Pro Arg Phe Lys Thr Asn Trp Ser Tyr Phe His Val Leu Gly Ala 290 295 300 Val Gly Val Tyr Phe Leu Met Val His Val Ile Ser Thr Asp Leu Phe 305 310 315 320 Leu Met Thr Phe Phe Phe Pro Phe Ile Trp Ala Phe Ile Ser Tyr Leu 325 330 335 Leu Phe Arg Lys Phe Ile Leu Lys Arg Tyr 340 345 INFORMATION FOR SEQ ID NO:1739: SEQUENCE CHARACTERISTICS: LENGTH: 615 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature 0.0. LOCATION 1...615 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1739 a Ile Leu Ile Glu Gly Val Phe Met Pro Lys His Ser Leu Glu Gin Ile 1 5 10 Lys Glu Lys Ile Thr Glu Arg Ser Lys Lys Thr Arg Glu Leu Tyr Leu 25 Glu Asn Thr Phe Asn Pro Lys Asn Gin Pro Lys Ile Glu Ser Leu Gly 40 Cys Ala Asn Ile Ala His Val Thr Ala Ser Met Pro Glu His Leu Lys 55 Met Pro Leu Gly Ser His Lys Arg Lys His Phe Ala Ile Ile Thr Ala 70 75 Tyr Asn Asp Met Leu Ser-Ala His Gin Pro Phe Lys Asn Tyr Pro Asp 90 Leu Ile Lys Lys Glu Leu Gin Glu His Asn Ala Tyr Ala Ser Val Ala 100 105 110 Ser Gly Val Pro Ala Met Cys Asp Gly Ile Thr Gin Gly Tyr Glu Gly 115 120 125 Met Glu Leu Ser Leu Phe Ser Arg Asp Val Ile Ala Leu Ser Thr Ala 130 135 140 Val Gly Leu Ser His Asn Val Phe Asp Gly Ala Phe Phe Leu Gly Val 145 150 155 160 Cys Asp Lys Ile Val Pro Gly Leu Leu Ile Gly Ala Leu Ser Phe Gly 165 170 175 Asn Leu Ala Ser Val Phe Val Pro Ser Gly Pro Met Val Ser Gly Ile 180 185 190 1277
C
C
C
C.
C C
C.
Glu Ile Val 225 Met Asn Ala Ile His 305 Asn Lys Gly Phe Gin 385 Lys Ser Leu Lys Glu 465 Pro Thr Val Ile Lys 545 Val Glu Leu Met Asn Asn 210 Gly Glu Asn Ser Leu 290 Thr Trp Val Gly Glu 370 Asn Asp Glu Gly Val 450 Arg Phe Thr Thr His 530 Asp Leu Thr Phe Ser 610 Tyr 195 Arg Thr Phe Pro Gly 275 Asn Leu Asp Tyr Leu 355 Asp Tyr Ala Pro Arg 435 Lys Phe Gin Asn Asp 515 Leu Gly Glu Leu Thr 595 Phe Glu Cys Met Leu 260 Lys Ala His Asp Pro 340 Ala Thr Thr Val Phe 420 Ala Ala Lys Gly Leu 500 Gly Ser Asp Lys Glu 580 Ser Gly Leu Phe 230 Leu Lys Leu Ile Ile 310 Asp Gly Val Thr Thr 390 His Ala Ile Ala Lys 470 Lys Ala Met Glu Ile 550 Phe Leu Arg Lys Leu 215 Tyr His Val Pro Gly 295 Ala Ala Ser Ile Ile 375 Pro Ser Asn Lys Ile 455 Glu Ser Leu Ser Gly 535 Glu Glu Glu Leu Val 615 200 Lys Gly Val Leu Leu 280 Leu Ile Ile Ala Lys 360 Met Phe Leu Gly Ile 440 Val Leu Asn Gin Gly 520 Ala Leu Lys Lys Asn 600 Gin 220 Ser Ser Ser Ile Gly 300 Cys Ile Ala Lys Thr 380 Asp Ile Ile Lys Gin 460 Phe Glu Tyr Lys Ala 540 Asn Asn Gly Ala 205 Ser Asn Phe Ala Asp 285 Gly Gly Pro Phe Glu 365 Gin Gin Leu Leu Asp 445 Ser Val Leu Lys Val 525 Ile Asn Pro Leu Glu 605 Tyr Gin Ile Lys 270 Glu Ser Val Leu Glu 350 Gly Lys Leu Arg Lys 430 Glu Glu Ala His Val 510 Pro Ile Ala Leu Gly 590 Glu His Met Asn 255 Arg Lys Thr Ile Leu 335 Ala Leu Gly Val Pro 415 Gly His Phe Val Lys 495 Ala Ser Lys Leu Phe 575 Arg Gly Asp Met 240 Pro Leu Ser Asn Leu 320 Ala Cys Leu Met Tyr 400 Val Asn Arg Leu Leu 480 Leu Leu Ala Ile Asn 560 Leu Glu Gly Lys Lys Ala Lys Ala Arg Gin Asp Phe Ala Met Gly Lys INFORMATION FOR SEQ ID NO:1740: SEQUENCE CHARACTERISTICS: LENGTH: 214 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein 1278 (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyl.ori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .214 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1740
V
V.
a. a.
V
V
V
*VV.
V a
V
V
V.
V
a Lys 1.
Ile Val Val1 Lys 65 Thr Pro Pro Glu Gly 145 Phe Ala Asp Arg Ser Pro Thr so Asn Gln Gly Leu Leu 130 Val1 Cys Leu Leu Ala 210 Pro Leu Leu Val1 Leu Leu Ile 115 Gly Lys Pro G lu Ile 195 Leu Ile Ala Arg Pro Glu Thr 100 Pro Tyr Leu Thr Asn 180 Gin Ala 5 Val Gin Ser Lys Gln Ile Gly Asn Leu Gly 165 Val Asn Leu Pro Ser Asn Met 70 Ala Lys Val1 Ala Asn 150 Gly Val Lys Arg Val Vai Leu Ile 40 Cys Ala Arg Val Gin Asn Leu Leu Ser Ser 120 Leu Lys 135 Ala Phe Ile Ser Cys Val Giu Trp 200 Val Val 25 Giu Gly Leu Giu Gly Ala Arg Gly Giu His 105 Ser Ser Phe Phe Asn Gly Ala Asp 170 Gly Gly 185 Asp Lys Giu Gly Ala Gly Ala Ala G lu Pro Pro 155 Asn Ser Ile Tyr Lys Gly Asp Lys Met Gin Asp Lys Ile Ile Glu Ile Pro G lu Ile Phe Lys Met 125 G lu Lys Arg Leu G lu 205 Ile Lys Ile Leu Leu Leu Lys 110 Gin Tyr Gly Ser Thr 190 Ile INFORMATION FOR SEQ ID NO:1741: SEQUENCE CHARACTERISTICS: LENGTH: 95 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1741 Asn Thr Ala Ile Val Ser Phe Leu Tnp Phe Ala Tyr Val Ser Ile Gly 10 Leu Thr Asn Phe Val Ala Val Gly Tyn Met Val Ser Leu Leu Gly Ala 25 Leu Phe Pro Lys 1279 Lys Arg Thr Pro Cys Thr Asn Arg Phe Tyr Leu Lys Ala Leu Leu 40 Ala Ile Phe Tyr His Ala Val Asn Asn Phe Leu Thr Gin Cys Pro 55 His Gin Val Arg Glu Phe Phe Ser Ser Arg His Ala Gin Gly Trp, 70 75 Arg Giu Thr Leu Pro Cys Ala Leu Ser Phe Gin Asn Ala Leu 90 9 INFORMATION FOR SEQ ID NO:1742: SEQUENCE CHARACTERISTICS: LENGTH: 360 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 360 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i742 Lys Lys Thr Pro Pro Ile Leu Cys Arg Leu Leu Gly 9.
4
I
Lys Lys Arg Leu Val Ala Phe Giu 65 Giu Ser Pro Ile Ser Ile Ile Asn 130 Asn Asp 145 Lys Ala Gin Asn Val Ser Ala Arg 210 Ser Gly 225 Glu Lys Ser Giu Leu Leu 35 Pro Ser Leu Met Giu 115 Asp Leu Ile Ser Phe 195 Ser Leu Vai Arg Pro 20 Ala* Arg Leu Lys Gly 100 Thr Phe Ala Leu Asp 180 Ala Lys Val Ala Ala 5 Gin Asp Gin Ser Leu Asp Thr Val Gin G ly 165 Gly Pro Phe Leu Lys 245 Leu Arg Ile Ile Asp 70 His Phe Arg Ala Ile 150 Pro Ser Phe Asn Ile 230 Leu Asn Cys Gly Giu 55 Ala Pro Val1 Gin Gin 135 Gly Gly Leu Asp His 215 Tyr Ser Gly Phe Gly 40 Cys Val Ile Gin Cys 120 Ala Gly Thr Lys Asp 200 Val Giu Lys Asp Met 25 Thr Val Arg Tyr Met 105 Leu Tyr Ile Gly Val 185 Leu Ser Ala Ala Tyr 265 10 Pro Asn Giu Phe Gly 90 Thr Asn Ala Lys Leu 170 Leu Glu Ala Leu Giu 250 Pro Lys Ala Val1 Tyr 75 Ser Asn Leu Ile Cys 155 Gly Pro Ile Giu Ser 235 Leu Ile Thr Arg Leu Leu Phe Asn Lys Ser 140 Giu Val1 Asp Leu Arg 220 Lys Thr Cys Phe G iu Phe Arg Ser Ala His Lys 125 Ala Ile Ser Glu Val1 205 Phe Arg Pro Arg Tyr Thr Gly Cys Lys Val1 Trp 110 Leu Met Asn Thr Gly 190 Trp Leu Lys Gin Leu 270 Ile Tyr Leu Glu Cys Ala Thr Leu Gin Ala Leu 175 Gly Gin Ser G ly Ile 255 Thr Leu Pro Giu Asp Lys Thr Phe Val Giu Pro 160 Ile His Tyr G ly Leu 240 Ile Leu 260 Asp Thr Phe Cys Ser Met Leu Gly Thr Leu Ala Ala Asp Val Ala Leu 1280 275 280 285 Thr Leu Gly Ala Arg Gly Gly Val Tyr Leu Cys Gly Gly Ile Ile Pro 290 295 300 Arg Phe Ile Asp Tyr Phe Lys Thr Ser Pro Phe Arg Ala Arg Phe Glu 305 310 315 320 Thr Lys Gly Arg Met Gly Ala Phe Leu Ala Ser Ile Pro Val His Val 325 330 335 Val Met Lys Lys Thr Pro Gly Leu Asp Gly Ala Gly Ile Ala Leu Giu 340 345 350 Asn Tyr Leu Leu His Asp Arg Ile 355 360 INFORMATION FOR SEQ ID NO:1743: SEQUENCE CHARACTERISTICS: LENGTH: 340 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein 9999 (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .340 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1743 Ser Gin Gly Leu Ile Phe Asp Lys Lys Lys Gin Lys Phe Leu Lys Asp 9.1 5 10 *Phe Lys Ala Gly Giu Leu Leu Tyr Gin Ser His Phe Lys Pro Leu Val .20 25 Glu Phe Ile Ala Giu Glu Leu Leu Lys Asn Ser Arg Ala Lys Ile Ile 40 Gin Ser Asn Cys Asn Lys Ala Leu Lys Val Vai Glu Glu Leu Gin Asn Thr Ile Lys Thr Thn Ile Giu Lys Gin Ile Asn Pro Gly Met Lys Giu 70 75 Thr Gin Asp Pro Gin Gin Giu Ala Ang Phe Asn Leu Asp Arg Sen Thr 90 Asp Lys Phe Ile Sen Asp Leu Glu Lys Ser Ala Phe Ser Lys Ile Asn 100 105 110 Gin Phe Glu Phe Asn Phe Arg Lys Giu Met His Giu Ang Ile Giu Arg 115 120 125 Gly Ile Gly Asn Asn Giu Cys Lys Glu Ile Phe Gly Asn Giu Leu Lys 130 135 140 Gin Arg Lys Thn Lys Leu Ile Giu Asp Ile Glu Arg Ang Phe Lys Glu 145 150 155 160 Cys Glu Giu Gin Phe Arg Gly Ser Val Gly Lys Asn Ile Glu Gin Leu 165 170 175 Giu Giu Arg Val Lys Asp Ser Leu Ala Ile Ile Lys Ang Ile Asn Asn 180 185 190 Leu Gly Leu Asn Pro Asn Ser Asn Phe Asn Met Asp Ser Gly Ile Asp 195 200 205 Thr Ile Giy Leu Phe Sen Sen Ile Gly Gly Leu Val Leu Lou Leu Leu 210 215 220 Thr Pro Val Vai Gly Glu Phe Ala Lou Ile Ala Gly Val Gly Leu Ala 225 230 235 240 Leu Val Gly Val 245 25025 Phe Phe Asp Ser Asp Tyr 255 1281 Lys Lys Ser Gln Gin Arg Lys Glu Val Asp Lys Asn Leu His Gin Ile 260 265 270 Cys Glu Lys Ile Val Gin Asp Val Lys Ser Arg Ile Glu Ser Tyr Lys 275 280 285 Asn Gly Ala Leu Gly Met Ile Glu Glu Leu Asn Ala Gly Phe Asn Lys 290 295 300 Leu Val Asp His Tyr Glu Arg Met Lys Arg Gin Leu Glu Glu Ala His 305 310 315 320 Glu Lys Leu Gly Tyr Ile Tyr Asn Ser Ile His Leu Thr lie Ser Asn 325 330 335 Arg Arg Ile Gin 340 INFORMATION FOR SEQ ID NO:1744: SEQUENCE CHARACTERISTICS: LENGTH: 219 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: S(A) ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...219 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1744 Ser Ala Leu Trp His Lys Asp Pro Thr Thr Ile Lys Gin Phe Gly Leu 1 5 10 Glu Ala Leu Asp Phe Phe Lys Pro His Glu Ile Glu Leu Leu Ile Val 25 Ala Cys Asn Thr Ala Ser Ala Leu Ala Leu Glu Glu Met Gin Lys Tyr 35 40 Ser Lys Ile Pro Ile Val Gly Val Ile Glu Pro Ser Ile Leu Ala Ile 55 Lys Arg Gin Val Glu Asp Lys Asn Ala Pro Ile Leu Val Leu Gly Thr 70 75 Lys Ala Thr Ile Gin Ser Asn Ala Tyr Asp Asn Ala Leu Lys Gin Gin 90 Gly Tyr Leu Asn Ile Ser His Leu Ala Thr Ser Leu Phe Val Pro Leu 100 105 110 Ile Glu Glu Ser Ile Leu Glu Gly Glu Leu Leu Glu Thr Cys Met His 115 120 125 Tyr Tyr Phe Thr Pro Leu Glu Ile Leu Pro Glu Val Ile Ile Leu Gly 130 135 140 Cys Thr His Phe Pro Leu Ile Ala Gin Lys Ile Glu Gly Tyr Phe Met 145 150 155 160 Gly His Phe Ala Leu Pro Thr Pro Pro Leu Leu Ile His Ser Gly Asp 165 170 175 Ala Ile Val Glu Tyr Leu Gin Gin Lys Tyr Ala Leu Lys Asn Asn Ala 180 185 190 Cys Thr Phe Pro Lys Val Glu Phe His Ala Ser Gly Asp Val Ile Trp 195 200 205 Leu Glu Arg Gin Ala Lys Glu Trp Leu Lys Leu 210 215 INFORMATION FOR SEQ ID NO:1745: 1282 SEQUENCE CHARACTERISTICS: LENGTH: 109 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...109 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1745 Gly Ile Lys Leu Gly Gly Ile Asn Met Ala Gly Thr Gin Ala Ile Tyr 1 5 10 Glu Ser Ser Ser Ala Gly Phe Leu Ser Gin Val Ser Ser Ile Ile Ser 20 25 Ser Thr Ser Gly Val Ala Gly Pro Phe Ala Gly Ile Val Ala Gly Ala S35 40 Met Thr Ala Ala Ile Ile Pro Ile Val Val Gly Phe Thr Asn Pro Gin 50 55 Met Thr Ala Ile Met Thr Gin Tyr Asn Gln Ser Ile Ala Glu Ala Val 70 75 Ser Val Pro Met Lys Ala Ala Asn Gin Gin Tyr Ser Gin Leu Tyr Gin 85 90 Gly Phe Asn Asp Gin Ser Met Ala Val Gly Thr Ile Ser S100 105 INFORMATION FOR SEQ ID NO:1746: SEQUENCE CHARACTERISTICS: LENGTH: 122 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 17..122 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1746 Phe Gin Phe Glu Arg Lys Arg Met Lys Phe Phe Thr Arg Ile Thr Asp 1 5 10 Ser Tyr Lys Lys Val Val Val Thr Leu Gly Leu Val Val Thr Thr Asn 25 Pro Leu Met Ala Val Thr Ser Pro Ala Thr Gly Val Thr Glu Thr Lys 40 Ser Leu Val Ile Gin Ile Ile Ser Val Leu Ala Ile Val Gly Gly Cys 55 Ala Leu Gly Val Lys Gly Ile Ala Asp Ile Trp Lys Ile Ser Asp Asp 70 75
I
Ile Met Phe 128B3 Lys Arg Gly Gin Ala Thr Vai Phe Ala Tyr Ala Gin Pro Ile Ala 90 Leu Ala Val. Ala Gly Gly Ile Ile Tyr Leu Ser Thr Lys Phe Giy 100 105 110 Asn Ile Giy Giu Ser Giy Giy Ala Ser 115 120 egos .00.
.9 0 INFORMATION FOR SEQ ID NO:1747: SEQUENCE CHARACTERISTICS: LENGTH: 991 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyiori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .991 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1747 Ser Gly Ile Ser Ile Lys Arg Gly Val Phe Val Ala ee.
'600 00 *9 1 Asp Phe Pro Pro 6S Val Ala Leu Phe Pro 145 Asp Cys Gly Asp Val 225 Val Phe Ile Glu Gin Phe 5o Giu Leu Ile Lys 130 Ser Arg Phe Th~r Leu 210 Thr Ile Met Ser Gin Lys Phe Thr Ser Val Gin Gly Lys Leu Leu Ile 195 Ile Pro Asp Arg Phe Lys Ile Lys Phe Val1 I le 100 Arg Val Giu Val Asp 180 Lys Giu Glu Giu Ala 260 5 Lys Giu Val Ile Ile 85 Val Met Lys Met Ser 165 Asp Leu Leu Phe Thr 245 Leu Leu Glu Leu 70 Leu Leu Giu Asn Ala 150 Ala Gly Giy His Lys 230 Asn Asn Thr Val Leu Phe 55 Ser Phe Val1 Arg Lys 135 Asn Ala Val Gly Ala 215 Phe Arg Giu I le Ile Lys 40 Asp Ser Gin Ala Ala 120 Ala Asp Asn Ile I le 200 Ser Asp Lys Glu Giu 25 Ala Gly Ile Ala Leu 105 Met Phe Ile Ser Leu 185 Asp Ile Phe Gin 265 Gin Gin Asp Gly Phe Tyr 90 Gly Lys Met His 170 Thr Phe His Gly 250 Lys Asp Glu Met Asn Ile 75 Glu Phe Phe Ser Leu 155 Leu Asn Leu Ser Thr 235 Leu Arg Leu Val1 Gin Arg Leu Pro Lys Lys Ile 140 As n Ala Asn Thr Val 220 Val Ile Glu Leu Ser Gin Lys Leu Phe Val Lys Lys 125 Phe Pro Asn Tyr Thr 205 Phe Lys Phe Ser Asp Lys Gin Lys Arg Gly Val Phe Giy Val Thr Leu Ile Asp Tlyr 110 Pro Phe Ser Met Asn Arg Asn Tyr 175 Ser Leu 190 Ser Lys Arg Asn Lys Lys Ser Asn Phe Tyr 270 Thr Leu Ala Gin Asn Phe Ile Val1 Arg Leu Lys Glu 160 Giu Leu Lys Phe Ile 240 Asp Asp As n 275 280 285 Glu Pro Val Met Asn Lys Lys His Phe Ala Asp Asn Asn Phe Giu Glu 1284 290 295 300 Phe Gin Arg Ile Ile Arg Aia Lys Leo Glu Asn Phe Lys Asp Arg Ile 305 310 315 320 Giu Leu Ile Giu Glu Leo Leu Ser Lys Tyr His Pro Thr Arg Leu Lys 325 330 335 Glu Tyr Thr Lys Asp Gly Ile Ile Tyr Ser Lys Gin Cys Glu Phe Tyr 340 345 350 Asn Phe Leu Val Gly Met Asn Glu Ala Pro Phe Ile Cys Asn Arg Lys 355 360 365 Asp Leu Tyr Leu Lys Giu Lys Met His Gly Giy Val Lys Giu Val Tyr 370 375 380 Phe Ala Asn Lys His Giy Lys Ile Leo Asn Asp Asp Leo Ser Giu Lys 385 390 395 400 Tyr Phe Ser Ala Ile Gu Ile Ser Glu Tyr Ala Pro Lys Ser Gin Ser 405 410 415 Asp Leu Phe Asp Lys Ile Asn Ala Leo Asp Ser Glu Phe Ile Phe Met 420 425 430 His Ala Tyr Ser Pro Lys Asn Ser Gin Val Leo Lys Asp Lys Leo Ala 435 440 445 0000 Phe Thr Ser Arg Arg Ile Ile Ile Ser Gly Gly Ser Lys Glu Gin Giy ses450 455 460 :,OOG Met Thr Leo Gly Cys Leo Ser Glu Leo Val Gly Asn Gly Asp Ile Thr 465 470 475 480 Leo Gly Ser Tyr Gly Asn Ser Leo Val Leo Phe Ala Asp Ser Phe Glu 485 490 495 Lys Met Lys Gin Ser Vai Lys Glu Cys Val Ser Ser Leu Asn Ala Lys .500 505 510 Gly Phe Leo Ala Asn Ala Ala Thr Phe Ser Met Glu Asn Tyr Phe Phe 515 520 525 Ala Lys His Cys Ser Phe Ile Thr Leo Pro Phe Ile Phe Asp Val Thr '.:530 535 540 Ser Asn Asn Phe Ala Asp Phe Ile Ala Met Arg Ala Met Ser Phe Asp GO. 0545 550 555 560 Gly Lys Glu Asp Asn Asn Ala Trp, Gly Asn Ser Val Met Thr Leu Lys .565 570 575 :**OGG Ser Glu Ile Asn Ser Pro Phe Tyr Leo Asn Phe His Met Pro Thr Asp &0&580 585 590 *0*000 Phe Gly Ser Ala Ser Ala Gly His Thr Leu Ile Leu Gly Ser Thr Gly 595 600 605 Ser Gly Lys Thr Val Phe Met Ser Met Thr Leu Asn Ala Met Gly Gin **.610 615 620 Phe Ala Tyr Asn Phe Pro Ala Asn Ile Ser Lys Asp Lys Gin Lys Leo 625 630 635 640 Thr Met Val Tyr Met Asp Lys Asp Tyr Giy Ala Tyr Gly Asn Ile Val 645 650 655 Ala Met Gly Gly Glu Tyr Val Lys Ile Giu Leu Gly Thr Asp Thr Gly 660 665 670 Leu Asn Pro Phe Ala Trp Aia Ala Cys Val Gin Lys Thr Asn Ala Thr 675 680 685 Met Glu Gin Lys Gin Thr Ala Ile Ser Val Val Lys Glu Leo Val Lys 690 695 700 Asn Leu Ala Thr Lys Ser-Asp Glu Lys Asp Giu Asn Gly Asn Ser Ile 705 710 715 720 Ser Phe Ser Leu Ala Asp Ser Asn Thr Leo Ala Ala Ala Val Thr Asn 725 730 735 Leo Ile Thr Gly Asp Met Asn Leo Asp Tyr Pro Ile Thr Gin Le Ile 740 745 750 Asn Ala Phe Gly Lys Asp His Asn Asp Pro Asn Gly Leo Val Ala Arg 755 760 765 Leo Ala Pro Phe Cys Lys Ser Thr Asn Gly Giu Phe Gin Trp Leo Phe 770 775 780 Asp Asn Lys Ala Thr Asp Arg Leo Asp Phe Ser Lys Thr Ile Ile Gly 785 790 795 800 Val Asp Gly Ser Sez- Phe Leu Asp Asn Asn Asp Val Ser Pro Phe Ile 805 810 815 1285 Cys Phe Val Ala 865 Pro Arg Thr Leu Arg 945 Phe Lys Phe Val Ala 850 Ile Ile Asn Giu Tyr 930 Gly Val1 Leu 835 Tyr Val Ala Asp Lys 915 Lys Ile Lys Gin Leu 820 Asp Phe Arg Asp Gly 900 Glu Gin Pro Giu Ala 980 Phe Ile Vai Leu Thr 885 Gly Phe Asp Lys Ile 965 Leu Ala Asp Arg Ala 870 Ile Asn Giu Gly Giu 950 Asp Arg Arg Glu Asp 855 Thr Arg Leu Ile Ser 935 Tyr Lys Gin Ile Gin Giu Ala Met Asp Giy Arg Arg 830 Gly Asp Pro Lys 845 Arg Lys Arg Asn Leu Leu Ala Cys 880 LysIle Phe Leu 895 Leu Ala Asn Val 910 Asp Arg Lys Ile 925 Ser Phe Asn Leu Thr Asp Thr Val 960 Ser Ile Ile Asp 975 Lys Giu Tyr 990
A*
INFORMATION FOR SEQ ID NO:1748: SEQUENCE CHARACTERISTICS LENGTH: 1183 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGA.NISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1183 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1748 Phe Leu Val Ala Leu Met Ile Pro Asn Leu Asp Ile Giu
I
Met Asn Asp Lys Arg Gin Asp Gly Asp 145 Thr Pro Asn Asn Glu Asn Thr 130 Pro Asn Gin Val Asp Giu Phe Leu 115 Gin Ser
S
Ala Phe Ala Asp Ala Ser Asp Ile Ile Ile Ser Asn 70 Asn Phe Thr Gin Asn Asn Asn Phe 55 Arg Lys Ile Gly Ile 135 Thr Thr Ala Lys Lys Pro Asp Ser Val1 140 Giy Glu Phe Pro Ile Thr Leu Phe 125 Ser ,Phe Gly Ala Ile Ile Ser Lys Ile 110 Gin His Met Glu Thr Ala Phe Lys Val Val Asp Gin Leu Lys Asn Asp Lys Lys Phe Gin Asn Glu Asn 160 150 Ile Ile Gin Pro Pro Ile Sen Asp Asp Lys Glu Lys Ala Glu Phe Leu 1286 165 170 175 Arg Set Ala Lys Gin Ala Phe Ala Gly Ile Ile Ile Gly Asn Gin Ile 180 185 190 Arg Set Asp Gin Lys Phe Met Gly Val Phe Asp Giu Ser Leu Lys Giu 195 200 205 Arg Gin Giu Ala Giu Lys Asn Gly Glu Pro Asn Gly Asp Pro Thr Gly 210 215 220 Gly Asp Trp Leu Asp Ile Phe Leu Ser Phe Val Phe Asn Lys Lys Gin 225 230 235 240 Ser Set Asp Leu Lys Giu Thr Leu Asn Gin Giu Pro Val Pro His Val 245 250 255 Gin Pro Asp Val Ala Thr Thr Thr Thr Asp Ile Gin Ser Leu Pro Pro 260 265 270 Giu Ala Arg Asp Leu Leu Asp Giu Arg Gly Asn Phe Ser Lys Phe Thr 275 280 285 Leu Gly Asp Met Asn Met Leu Asp Val Glu Gly Val Ala Asp Ile Asp 290 295 300 Pro Asn Tyr Lys Phe Asn Gin Leu Leu Ile His Asn Asn Ala Leu Ser 305 310 315 320 Set Val Leu Met Gly Ser His Asn Gly Ile Giu Pro Glu Lys Val Set 325 330 335 Leu Leu Tyr Gly Asn Asn Gly Gly Pro Giu Ala Arg His Asp Trp Asn 340 345 350 Ala Thr Val Giy Tyr Lys Asn Gin Arg Gly Asp Asn Val Ala Thr Leu 3ieA 5 360 365 IeAnVal His Met Lys Asn Gly Ser Gly Leu Vai Ile Ala Gly Giy 370 leAn30375 38040 Glu Lys Gly IeAnAsn Pro Set Phe Tyr Leu Tyr Lys Giu Asp Gin 385 3039540 Leu Thr Gly Ser Gin Arg Ala Leu Ser Gin Giu Glu Ile Gin Asn Lys 405 410 415 *Val Asp Phe Met Glu Phe Leu Ala Gin Asn Asn Ala Lys Leu Asp Asn 420 425 430 Leu Set Lys Lys Giu Lys Giu Lys Phe Gin Asn Giu Ile Glu Asp Phe 435 440 445 Gin Lys Asp Set Lys Ala Tyr Leu Asp Ala Leu Gly Asn Asp His Ile 450 455 460 Ala Phe Val Ser Lys Lys Asp Lys Lys His Leu Ala Leu Vai Ala Giu 465 470 47 480 Phe Gly Asn Gly Glu Leu Ser Tyr Tht Leu Lys Asp Tyr Gly Lys Lys 485 490 495 ***Ala Asp Lys Ala Leu Asp Arg Giu Ala Lys Thr Thr Leu Gin Gly Ser *500 505 510 Leu Lys His Asp Gly Val Met Phe Val Asp Tyt Set Asn Phe Lys Tyr 515 520 525 Thr Asn Ala Ser Lys Set Pro Asp Lys Gly Val Gly Ala Thr Asn Gly 530 535 540 Val Set His Leu Glu Ala Gly Phe Set Lys Val Ala Val Phe Asn Leu 545 550 555 560 Pro Asn Leu Asn Asn Leu Ala Ile Thr Set Val Val Arg Gin Asp Leu 565 570 575 Glu Asp Lys Leu Ile Ala-Lys Gly Leu Set Pro Gin Giu Ala Asn Lys 580 585 590 Leu Val Lys Asp Phe Leu Set Set Asn Lys Glu Leu Val Gly Lys Ala 595 600 605 Leu Asn Phe Asn Lys Ala Val Ala Giu Ala Lys Asn Thr Gly Asn Tyr 610 615 620 Asp Glu Val Lys Gin Ala Gin Lys Asp Leu Giu Lys Set Leu Lys Lys 625 630 635 640 Arg Glu Atg Leu Glu Lys Asp Val Ala Lys Asn Leu Glu Set Lys Set 645 650 655 Gly Asn Lys Asn Lys Met Giu Ala Lys Set Gin Ala Asn Set Gin Lys 660 665 670 Asp Glu Ile Phe Al, Leu Ile Asn Lys Glu Ala Asn Arg Asp Ala Arg 675 680 685 1287 Ala Ile Ala Tyr Ala Gln Asn Leu Lys Gly Ile Lys Arg Giu Leu Ser 690 695 700 Asp Lys Leu Glu Asn Ile Asn Lys Asp Leu Lys Asp Phe Ser Lys Ser 705 710 715 720 Phe Asp Giu Phe Lys Asn Gly Lys Asn Lys Asp Phe Ser Lys Ala Giu 725 730 735 Giu Tbr Leu Lys Ala Leu Lys Gly Ser Val Lys Asp Leu Gly Ile Asn 740 745 750 Pro Giu Trp Ile Ser Lys Val Giu Asn Leu Asn Ala Ala Leu Asn Giu 755 760 765 Phe Lys Asn Gly Lys Asn Lys Asp Phe Ser Lys Val Thr Gin Ala Lys 770 775 780 Ser Asp Leu Giu Asn Ser Ile Lys Asp Val Ile Ile Asn Gin Lys Ile 785 790 795 800 Thr Asp Lys Vai Asp Asn Leu Asn Gin Ala Val Ser Val Ala Lys Ala 805 810 815 Thr Gly Asp Phe Ser Gly Val Giu Gin Ala Leu Ala Asp Leu Lys Asn 820 825 830 Phe Ser Lys Giu Gin Leu Ala Gin Gin Ala Gin Lys Asn Giu Asp Phe 835 840 845 Asn Thr Gly Lys Asn Ser Ala Leu Tyr Gin Ser Val Lys Asn Gly Val 850 855 860 Asn Gly Thr Leu Vai Gly Asn Gly Leu Ser Lys Ala Glu Ala Thr Thr Leu Ser Lys Asn Phe Ser Asp Ile Lys Lys Giu Leu Asn Ala Lys Leu *885 890 895 Gly Asn Phe Asn Asn Asn Asn Asn Asn Gly Leu Giu Asn Ser Thr Giu Pr ierr900 905 910 PoIeTrThr Gin Val Ala Lys Lys Val Lys Ala Lys Ile Asp Arg 915 920 925 Leu Asp Gin Ile Ala Ser Gly Leu Gly Asp Val Gly Gin Ala Ala Ser *930 935 940 Phe Leu Leu Lys Arg His Asp Lys Val Asp Asp Leu Ser Lys Val Gly 945 950 955 960 Leu Ser Ala Asn His Glu Pro Ile Tyr Ala Thr Ile Asp Asp Leu Giy 965 970 975 Giy Pro Phe Pro Leu Lys Arg His Asp Lys Val Asp Asp Leu Ser Lys 980 985 990 Val Gly Leu Ser Arg Giu Gin Lys Leu Thr Gin Lys Ile Asp Asn Leu 995 1000 1005 Asn Gin Ala Val Ser Giu Ala Lys Ala Ser His Phe Asp Asn Leu Asp .1010 1015 1020 SGin Met Ile Asp Lys Leu Lys Asp Ser Thr Lys Lys Asn Val Val Asn 1025 1030 1035 1040 Leu Tyr Vai Glu Ser Ala Lys Lys Val Pro Thr Ser Leu Ser Ala Lys 1045 1050 1055 Leu Asp Asn Tyr Ala Thr Asn Ser His Thr Arg Ile Asn Ser Asn Val 1060 1065 1070 Lys Asn Gly Thr Ile Asn Giu Lys Ala Thr Gly Met Leu Thr Gin Lys 1075 1080 1085 Asn Ser Glu Trp Leu Lys Leu Val Asn Asp Lys Ile Val Ala His Asn 1090 1095 1100 Val Gly Ser Ala Pro Leu Ser Ala Tyr Asp Lys Ile Gly Phe Asn Gin 1105 1110 1115 1120 Lys Asn Met Lys Asp Tyr Ser Asp Ser Phe Lys Phe Ser Thr Arg Leu 1125 1130 1135 Ser Asn Ala Val Lys Asp Ile Lys Ser Gly Phe Val Gin Phe Leu Thr 1140 1145 1150 Asn Ile Phe Ser Met Gly Ser Tyr Ser Leu Met Lys Ala Ser Val Glu 1155 1160 1165 His Gly Val Lys Asn Thr Asn Thr Lys Gly Gly Phe Gin Lys Ser 1170 1175 1180 INFORMATION FOR SEQ ID NO:i749: 1288 SEQUENCE CHARACTERISTICS: LENGTH: 224 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .224 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1749 Ala Leu Ser Leu Ala Ser Ile Leu Ala Arg Val Glu Glu Leu Ala Lys 1 5 10 Leu Ile Asn Asn Asn Asn Asn Asn Lys Lys Leu Arg Gly Phe Phe Leu 25 Lys Val Leu Leu Ser Leu Val Val Phe Ser Ser Tyr Gly Ser Ala Asn 9..35 40 Asp Asp Lys Glu Ala Lys Lys Glu Ala Leu Glu Lys Glu Lys Asn Thr 55 *Pro Asn Gly Leu Val Tyr Thr Asn Leu Asp Phe Asp Ser Phe Lys Ala 70 75 Thr Ile Lys Asn Leu Lys Asp Lys Lys Val Thr Phe Lys Glu Val Asn 90 Pro Asp Ile Ile Lys Asp Glu Val Phe Asp Phe Val Ile Val Asn Arg .9100 105 110 *Val Leu Lys Lys Ile Lys Asp Leu Lys His Tyr Asp Pro Val Ile Glu 115 120 125 Lys Ile Phe Asp Glu Lys Gly Lys Glu Met Gly Leu Asn Val Glu Leu 130 135 140 Gln Ile Asn Pro Glu Val Lys Asp Phe Phe Thr Phe Lys Ser Ile Ser 145 150 1S 160 Thr Thr Asn Lys Gin Arg Cys Phe Leu Sen Leu His Gly Glu Thn Ang 165 170 175 *Glu Ile Leu Cys Asp Asp Lys Leu Tyr Asn Val Leu Leu Ala Val Phe ~9"180 185 190 Asn Ser Tyr Asp Pro Asn Asp Leu Leu Lys His Ile Ser Thr Ile Glu 195 200 205 Sen Leu Lys Lys Ile Phe Tyr Thr Ile Thr Cys Glu Ala Val Tyr Leu 210 215 220 INFORMATION FOR SEQ ID NO:1750: SEQUENCE CHARACTERISTICS: LENGTH: 154 amino acids TYPE: amnino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature 1289 LOCATION .154 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1750 1Asn Asn Ala Lys Asn Lys Asn Lys Giy Val Lys Ser Met Lys Thr Asn Ph Phe Ser Gin Ile Ile Met Giy Ser 145 Asn Pro Leu Leu Ser Trp Pro 130 Ser Phe Asp Asn
LYS
Lys Pro Leu 120 Tyr Leu Ala Gin Ser Giu Asn Asn 105 Met Gly Gly Ile Ile Val Gin Ly* Giy Met 125 Thr Giy Asp Arg Val Asp Asn Asn Ser Met Ile Asp Ala Asp Ala Asp a.
a a. a 'a a.
a a a a a .a a aa a a INFORMATION FOR SEQ ID NO:i7Sli SEQUENCE CHARACTERISTICS: LENGTH: 518 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .518 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1751 Pro Leu Val Lys Ile Arg Leu Phe Asp Phe Thr Ile Arg Leu Phe Lys 1 Pro Ile Ile Lys Ala Ile Gin Lys Phe Arg Ala Asp Ala Asp Lys 120 Ala Ile Leu Lys Ala Ser Gin Phe 105 Ser Leu Arg Lys Tyr Giy Ala Giu Lys Ala Asp Lys Gly Leu Met Ala 75 Giu Leu Leu Thr Ile Val1 Ile Lys Arg Leu Asp Gly 140 As n Arg Val Gly Val1 Arg Thr Ser 125 Leu Val Val1 Thr Trp G ly Leu G iu 110 Leu Gly Phe Leu Ile Gly Gin Lys Asp Ile Ala Gin Met Trp Gin Ile Asp Gin Asn Thr Lys 1290 145 150 155 160 Asp Gly Val Phe Asp Giu Giu Leu Tyr Lys Asn Ile Leu Lys Gin Ser 165 170 175 His Tyr Arg Pro Lys His Phe Giu Giu Ser Val Giu Arg Leu Leu Ile 180 185 190 Leu Gin Lys Ile Ser Ala Leu Phe Pro Lys Thr Thr Thr Pro Leu Giu 195 200 205 Gin Ser Ser Leu Ser Leu Trp Ala Lys Leu Gin Asp Lys Leu Asp Ile 210 215 220 Leu Ile Leu Asn Pro Asn Asp Val Lys Ile Ser Leu Asn Glu Giu Giu 225 230 235 240 Met Lys Lys Tyr Tyr Giu Asn His Arg Lys Asp Phe Lys Lys Pro Thr 245 250 255 Ser Phe Lys Thr Arg Ser Leu Tyr Phe Asp Ala Ser Leu Giu Lys Thr 260 265 270 Asp Leu Lys Giu Leu Glu Giu Tyr Tyr His Lys Asn Lys Val Ser Tyr 275 280 285 Leu Asp Lys Glu Gly Lys Leu Gin Asp Phe Lys Ser Val Gin Giu Gin 290 295 300 Val Lys His Asp Leu Asn Met Gin Lys Ala Asn Giu Lys Ala Leu Arg 305 310 315 320 Ser Tyr Ile Ala Leu Lys Lys Gly Asn Ala Gin Asn Tyr Thr Thr Gin sp325 330 335 ApPhe Giu Lys Asn Asn Ser Pro Tyr Thr Ala Giu Ile Thr Gin Lys Le hrAa340 345 350 LeuThrAlaLeu Lys Pro Leu Giu Val Leu Lys Pro Giu Pro Phe Lys 355 360 365 *Asp Gly Phe Ile Val Val Gin Leu Val Ser Gin Ile Lys Asp Giu Leu *370 ~375 380 Gin Asn Phe Asp Giu Ala Lys Ser Ala Leu Lys Thr Arg Leu Thr Gin 385 390 395 400 *Giu Lys Thr Leu Met Ala Leu Gin Thr Leu Ala Lys Giu Lys Leu Lys spPe y Gy405 410 415 AspPheLysGlyLys Ser Val Gly Tyr Val Ser Pro Asn Phe Gly Gly 420 425 430 Thr Ile Ser Giu Leu Asn Gin Giu Giu Ser Ala Lys Phe Ile Asn Thr 435 440 445 ,Leu Phe Asn Arg Gin Glu Lys Lys Gly Phe Val Thr Ile Gly Asn Lys 450 455 460 Val Val Leu Tyr Gin Ile Thr Giu Gin Asn Phe Asn His Pro Phe Ser 465 470 475 480 *:Ala Giu Giu Asn Gin Tyr Met Gin Arg Leu Val Asn Asn Thr Lys Thr 485 490 495 Asp Phe Phe Asp Lys Ala Leu Ile Giu Giu Leu Lys Lys Arg Tyr Lys 500 505 510 Ile Val Lys Tyr Ile Gin 515 INFORMATION FOR SEQ ID NO:1752: SEQUENCE CHARACTERISTICS: LENGTH: 157 amino acids TYPE: amino acid MD TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: 1 NAME/KEY: misc_feature 1291 LOCATION .157 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1752 Lys Gly Lys Leu Gly Leu Phe Tyr Tyr Phe Ser Asp Leu Leu Giu Ser 1 5 10 Leu Ile Cys Phe Ser Asn Ser Cys Cys Lys Ala Cys Cys Cys Phe Ser 25 Phe Phe Giu Arg Arg Arg Phe Phe Leu Gly Phe Phe Ser Phe Phe Glu 40 Giu Val Ser Gly Ser Phe Giu Ala Val Ser Leu Ser Val Leu Ala Leu so 55 Val Ile Gly Ser Arg Ser Gly Leu Glu Giu Phe Cys Val Leu Glu Glu 70 75 Leu Ilie Asn Ser Gly Leu Ser Val Trp Leu Ser Ser Ser Pro Leu Leu 90 Leu Phe Trp Asn Ala Ala Leu Val Ser Phe Ser Ala Cys Ser Ser Ile 100 105 110 Phe Leu Arg Thr Ile Ala Ser Thr Phe Leu Ala Phe Ser Phe Trp Leu 115 120 125 Thr Leu Thr Met Leu Ile Lys Tyr Leu Ile Tyr Pro Ser Tyr Met Ser 130 135 140 Pro Asn Cys Ser Cys Lys Ala Pro Lys Ser Giu Pro Leu *145 150 155 INFORMATION FOR SEQ ID NO:1753: SEQUENCE CHARACTERISTICS: LENGTH: 206 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .206 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1753 Gly Leu Leu Lys Pro Leu Glu Giu Thr Giu Ile Lys Ala Cys Asn Lys 1 5 10 Asp Ile Leu Pro Leu Lys Pro Tyr Glu Lys Ala Lys Leu Ile Ala Tyr 25 Ile Pro Gln Val Giu Tyr Tyr Ala Phe Asn Phe Ser Val Leu Asp Phe 40 Val Leu Met Gly Lys Ala Thr His Leu Asn Leu Phe Ala Met Pro Lys so 55 Ala Lys His Ile Lys Glu Ala Thr Ser Val Leu Glu Arg Leu Asp Leu 70 75 Glu Ser Leu Lys Asp Gin Gly Ile Asn Asp Leu Ser Gly Gly Gin Arg 90 Gin Met Val Leu Leu Ala Arg Ser Leu Leu Gin Arg Thr Pro Leu Leu 100 105 110 Leu Leu Asp Giu Pro Thr Ser Ala Leu Asp Leu Lys Asn Gin Ala Leu 115 120 125 Phe Phe Asp Ala Ile Lys Asp Glu Met Lys Lys Arg Giu Leu Ser Val 130 135 140 Leu Val Asn Ile His Asp Pro Asn Leu Val Ala Arg His Ser Thr His 1292 145 150 155 160 Val Val Met Leu Lys Asp Lys Lys Leu Phe Leu Gin Ala Ser Thr Pro 165 170 175 Ile Ala Met Thr Ser His Asn Leu Ser Ala Leu Tyr Asp Thr Pro Leu 180 185 190 Glu Ala Ile Trp His Asp Asp Lys Leu Val Val Tyr Ala Leu 195 200 205 INFORMATION FOR SEQ ID NO:1754: SEQUENCE CHARACTERISTICS: LENGTH: 113 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...113 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1754 Lys Lys Lys Lys Asn Asp Glu Lys His Ile Ala Lys His Phe Val Ala 1 5 10 Val Ser Thr Asn Lys Glu Ala Val Gin Gin Phe Gly Ile Asp Glu His 20 25 Asn Met Phe Gly Phe Trp Asp Phe Val Gly Gly Arg Tyr Ser Leu Trp 40 Ser Ala Ile Gly Leu Ser Ile Met Ile Tyr Leu Gly Lys Lys Asn Phe 50 55 Asn Ala Leu Leu Lys Gly Ala Tyr Leu Met Asp Glu His Phe Arg Asn 65 70 75 Ala Pro Phe Glu Ser Asn Leu Pro Val Leu Met Gly Leu Ile Gly Val 90 Trp Tyr Ile Asn Phe Phe Gin Ser Lys Gly His Leu Ile Ala Pro Tyr S* 100 105 110 Asp INFORMATION FOR SEQ ID NO:1755: SEQUENCE CHARACTERISTICS: LENGTH: 156 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...156
I
1293 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1755 His Asn Lys Thr Arg Met Lys Arg Ala Lys Arg Arg Lys Phe Ile Thr 1 5 10 Lys Phe Ser Arg Tyr Tyr Thr Pro Ser Val Leu Phe Ile Ala Leu Met 25 Ile Ala Val Leu Pro Pro Leu Phe Ser Met Gly Ser Phe Asp Glu Trp 40 Ile Tyr Arg Gly Leu Val Ala Leu Met Val Ser Cys Pro Cys Ala Leu 55 Val Ile Ser Val Pro Leu Gly Tyr Phe Gly Gly Val Gly Ala Ala Ser 70 75 Arg Lys Gly Ile Leu Met Lys Gly Val His Val Leu Glu Val Leu Thr 90 Gin Thr Lys Ser Ile Ala Phe Asp Lys Thr Gly Thr Leu Thr Lys Gly 100 105 110 Val Phe Lys Val Val Asp Ile Val Pro Gin Asn Gly His Ser Lys Glu 115 120 125 Glu Val Cys Ile Thr Leu Leu Ala Arg Ser Phe Tyr Pro Arg Thr Arg 130 135 140 Ser Leu Tyr Pro Phe Lys Lys His Ala Lys Lys Cys 145 150 155 INFORMATION FOR SEQ ID N0:1756: SEQUENCE CHARACTERISTICS: LENGTH: 99 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...99 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1756 Arg Ser Thr Leu Ala Ser Ala Asp Val Gly Ile Gly Met Gly Lys Gly 1 5 10 Ser Glu Leu Ser Lys Gin Ser Ala Asp Ile Val Ile Thr Asn Asp Ser 25 Leu Ser Ser Leu Val Lys Val Leu Ala Ile Ala Lys Lys Thr Lys Ser 40 Ile Ile Trp Gin Asn Ile Leu Phe Ala Leu Gly Ile Lys Ala Val Phe -55 Ile Val Leu Gly Leu Met Gly Val Ala Ser Leu Trp Glu Ala Val Phe 70 75 Gly Asp Val Gly Val Thr Leu Leu Asp Leu Ala Asn Ser Met Arg Thr 90 Met Arg Ala INFORMATION FOR SEQ ID NO:1757: SEQUENCE CHARACTERISTICS: LENGTH: 361 amino acids TYPE:' amino acid 1294 TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .361 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1757 His Gin Sen Phe Lys Arg Ala Phe Giu Pro Arg Arg Lys Gly Ang Val 1 5 10 Phe Arg Ile Met Gly Phe Giu Lys Ser Ile Leu Asp Asn Lou Asn Gly 25 Ala Gin Lys Ile Ala Ala Cys His Ile Gin Gly Pro Leu Leu Ile Leu 40 Ala Gly Ala Gly Ser Gly Lys Thr Lys Thr Leu Thn Ser Arg Lou Ala 55 *Tyr Leu Ile Gly Ala Cys Gly Val Pro Sen Giu Asn Thr Leu Thr Lou 70 75 Thr Phe Thr Asn Lys Ala Sen Lys Giu Met Gin Giu Arg Ala Leu Lys 90 *Leu Leu Lys Asn Gin Ala Leu Ile Pro Pro Leu Leu Cys Thr Phe His *,100 105 110 *Arg Phe Gly Leu Leu Phe Leu Ang Gin His Met Asn Lou Lou Lys Ang 115 120 125 Ala Cys Asp Phe Ser Val Lou Asp Ser Asp Giu Val Lys Thr Leu Cys 130 135 140 *Lys Gin Leu Lys Ile Ser Asn Phe Arg Ala Se Ile Ser Gin Ile Lys 145 150 155 160 Asn Gly Met Met Asp Leu Sen Val Gin Asp Sen Giu Cys Tyr Lys Ala 165 170 175 *Tyr Giu Leu Tyr Gin Asn Ala Leu Lys Lys Asp Asn Leu Val Asp Phe *180 185 190 Asp Asp Leu Leu Cys Lou Sen Lou Lys Ile Lou Gin Asp Asn Glu Lys 195 200 205 *Lou Ala Lys Giu Thn Sen Giu Arg Tyr His Tyr Ile Met Val Asp Giu 210 215 220 Tyr Gin Asp Thn Asn Ala Leu Gin Leu Giu Phe Leu Lys Gin Lou Sen 225 230 235 240 Phe Thn His His Asn Leu Cys Val Val Gly Asp Asp Asp Gin Ser Ile 245 250 255 Tyr Gly Phe Arg Gly Ala Asp Ile Ser As Ile Leu Asn Phe Sen Lys 260 265 270 His Phe Lys Gly Ala Lys Ile Val Lys Leu Giu Thr Asn Tyr Arg Ser 275 280 285 Sen Ala Glu Ile Lou Ald' Cys Ala Asn Ser Lou Ile Ser His Asn Gin 290 295 300 His Arg His Ile Lys Thr Lou Gin Ser Phe Lys Gly Sen His Lys Sen 305 310 315 320 Val Ile Cys Lys Giu Tyr Pro Thn Gin Lys Giu Giu Ser Lou Asp Val 325 330 335 Ala Tyr Gin Ile Gin Ser Pro Phe Lys Giu Gly Ang Giu Phe Ang Lys 340 345 350 Tyr Arg Tyr Phe Val Sen Phe Lys Trp 355 360 INFORM4ATION FOR SEQ ID NO:1758: 1295 SEQUENCE CHARACTERISTICS: LENGTH: 842 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...842 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1758 a a ft Phe 1 Asn Pro Ser Ile Ser Thr Ala Gly Met 145 Leu His Leu Ser Leu 225 Tyr Ala Asn Met Asn 305 Thr Pro Val Lys Ser Lys 50 Ala Leu Asn Glu Lys 130 Gin His Asn Asp Ala 210 Tyr Lys Gly Ala Phe 290 Ala Tyr Lys Asn Leu Glu Leu Leu Thr Ala 115 Asp Lys Leu Leu Leu 195 Ile Tyr Lys Glu SPhe 275 SLys SGin Lys SAsp Glu 20 Lys Phe Gly Leu Ala 100 Glu Ser Ala Phe Gly 180 Phe Asp His Ser Tyr 260 Leu Asp Asp Gin Leu 340 5 Lys Gin Phe Ile Gly 85 Thr Gly Leu Ser Asp 165 Val Asp Ala Tyr Phe 245 Phe SLys Glu Glu Ala 325 i Asn Glu Ala Lys Leu 70 His Thr Gin Lys Leu 150 Lys Ile Ser Leu Leu 230 Tyr Glu Pro Thr Leu 310 Leu Ala Thr Leu Gln 55 Leu Lys Asn Ile Arg 135 Leu Ile Lys Ser Val 215 Lys Ser SAla Asn SAsn 295 SAla SGlu Leu Ala ?ro ;lu 10 Leu Ser Lys Asn Glu 120 Asn Tyr Ala Phe Ile 200 Thr Ile Tyr Leu Ala 280 Ala Leu His Met Ser 360 Leu 25 Gin Leu Leu Glu Glu 105 Asn Asp Glu Ser Lys 185 Ala Ala Val Ala Ser 265 Arg Tyr Gly Leu SAla 345 Glu 10 Lys Thr His lie Asn 90 Thr Leu Glu Gin Phe 170 Glu Ser Tyr Arg Tyr 250 Pro Leu Lys Let Gli 33( Lei Ala Gly Ile Asn Ala 75 Lys Pro Asp Ser Gly 155 Ser' Lys Lys His Asp 235 SAla Leu SAla SGin SLeu 315 i His 0 u Glu a Leu Ile 3er Lys Leu G1n Asn Leu Gin 140 Gin Gin Asp Glu Leu 220 Thr Leu Met Ser Leu 300 Gin Tyr Leu Lys His Lys Lys Ile Thr Asp Pro 125 Val Lys Gly Phe Asn 205 Gin Leu Lys His Lys 285 Gin SAla SLeu SVal Leu Ser Ile Lys Val Ser Thr 110 Asp Asp Asp Ile Asn 190 Ala Asp Tyr Ser Pro 270 Leu Lys Arg His Sei 35( Ala Lys Lys Leu Ala I Leu Asn Leu Ala Glu Ala 175 Gly Ser Ala Lys Tyr 255 SAsn Phe SSer Leu SAsn 335 r Leu SSer a Ser Ile Ser [yr Leu Gln Asn Ile Met Ala 160 Ser Ala Val Asp Asp 240 Tyr Ser Leu Ala Gly 320 Tyr Lys His Leu Asn Glu Glu Gin Asn Ser Leu Glu Glu Lys Gly Gly Glu Met Gly Asp Thr Leu Lys 355 365 Thr Gin Glu Asp Thr Leu Leu Ala Asn Ser Phe Tyr Pro Ile Lys Pro 1296 C C C.
C.
CC*C
C. *C
C
C
C.
C
C.
C
C
370 Thr Ile 385 Trp Asn Leu Phe Gly Val Asp Leu 450 Ile Ala 465 Arg Leu Pro Asn Leu Giu Lou Asn 530 His Phe 545 Asn Phe Ser Ser Trp Leu Ala Val 610 Phe Gly 625 Phe Tyr Ser Ile Met Gin Met Val 690 Ala Ser 705 Ala Leu Tyr Gin Ile Leu Ala Lou 770 Ile Arg 785 Ser Ala Pro Tyr Asn Gin Asn Thr Tyr Ile 435 G iu Asp Lys Asn Asn 515 Ser Thr Tyr Leu Lys 595 Phe Asn Giu Tyr Gly 675 Asn Lou Val Asn Ala 755 Trp Tyr Leu Phe Giu 835 Pro Met Gin Tyr 405 Tyr Ala 420 Giu Giu Gly Ala Lys Asn Lys Ala 485 Aia Leu 500 Tyr His Ala Asp His Glu Ser His 565 Ile Ala 580 Asn Ala Ala Lys Lou Lys Ile Val 645 Thr Leu 660 Pro Ile Asp Leu Giu Arg Ser Leu 725 Leu Ile 740 Gly Lou Leu Glu Ala Leu Asn His 805 Asp Phe 820 Glu Lys 375 Phe Leu 390 Phe Giu Pro Phe Gly Lou Ser Lou 455 Ala Lou 470 Lou Ser Lou His Lys Ala Tyr LoU 535 Asp Thr 550 Asp Phe Tyr Lou Pro Lys Giu Ser 615 Lys Met 630 Sor Tyr Lou Asp Lou Giy Asp His 695 dly Giu 710 Phe Gin Asp Gly Thr Tyr Lou Gly 775 G ly -Leu 790 Phe Lou Giu Ile Gly Giu Asp Lys Giu Giy Lys Arg 410 Lys Val Lou 425 Phe Lou Lou 440 Ala Phe Lys Lys Gly Lou Phe Phe Asp 490 Tyr Asn Val 505 Tyr Phe His 520 Ser Ala Val Thr Glu Phe Sor Ser Pro 570 Asn Tyr Arg Lys Lou Pro 600 Lys Asp Lys Lou Pro Lys Tyr Asp Ala 650 Ser His Lys 665 Arg His Phe 680 Gin Giu Arg Ala Pro Msn Gly Gin Tyr 730 Lou Lys Asp 745 Ile Ala Gin 760 Lys Lou Asp Lou Tyr Gin Ala Ile Lys 810 Asp Thr Asn 825 Pho Lou Giu 840 Arg 395 Asp Asp Asp Arg Lys 475 Lou Gly Phe Phe Leu 555 Thr Thr Phe Lys Asp 635 Ser Ile Tyr Lou Asp 715 Giu Asn Asn Asp Arg 795 Thr 380 Ala Phe Ser Ser Giy 460 Giu Sor Leu Lou Ala 540 Arg Gin Asn Tyr Lou 620 Lou Ile Ser Thr Lou 700 Trp Lys Giu Msn Pro 780 Lys Ser Lys Giu Ile Tyr Lys Glu 430 Asp Thr 445 Arg Lou Lou Giu Lou Lys Ile Tyr 510 Arg Ala 525 Val Lou Giu Ile Lys Ala Trp Asp 590 Tyr Aia 605 Met Val Ile Ser Arg His Trp Asp 670 Tyr Met 685 Giu Gin Lou Giu Ala Sor Ala Arg 750 Tyr Msn 765 Msn Msn Gly Asp Asp Phe Arg Phe 400 Arg Lou 415 Thr Lou Gin Lys Met Ala Lys Lys 480 Msn Ser 495 Ala Gin Phe His Ala Ser Thr Giu 560 Lou Lou 575 Met Asp Lou Glu Gin Ser Asn Ile 640 Thr Lou 655 Gin Thr Gly Phe Lys Ile Asn Lou 720 Ala Lou 735 Lou Lys Msn Ala Glu Asn Lou Lys 800 Ser Sor 815 Lou Lou Lys Giu Arg Lou 830 INFORMATION FOR SEQ ID NO:1759: Wi SEQUENCE CHARACTERISTICS: LENGTH: 356 amino acids 1297 TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION .356 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1759 9 9 9 9
S
*a Lys 1 Thr Ile Gin Asp Ile Val Met Leu Tyr 145 Leu Glu Glu His Sen 225 Val Sen Ile Va1 Asp 305 Ile Leu Ala ial Arg Asn Asn 50 Leu 4 Ihr in Lys Asn 130 Leu Gly Arg Phe Lys 210 Ile Asp Met Leu Asp 290 rhr Asn Ala Ala 3Gl Arg Leu Thr 115 Ala Ala Tyr Leu Gly 195 Val Leu Arg Gin Ile 275 Asn r Asp Leu Phe Glu Glu Ile 100 Gly Met His Ser Glu 180 Phe Gin Ile Arg Val 260 Thr Leu 5 Arg Glu Glu Lys Ala Gly Glu Lys Arg Val 165 Ile Asp Lys Asp Met 245 Glu Glu Tyr Lys Trp Pro Glu Thr 70 Sen Gly Gly Gly Asp 150 Gly Tyr Tyr Sen Glu 230 Glu Val Glu Lys Ala 310 Glu Ile rhr Leu 55 Leu Lys Met Lys Glu 135 Sen Thr Ser Leu His 215 Ala Asn Asp Gly Ile 295 Asn Val Lys Tyr 40 Lys Leu Arg Va1 Thr 120 Ser Lys Ile Lys Arg 200 Ala Arg Tyr Phe Ile 280 Glu LTyr Val 3m 25 3 iu Lys Glu Ile Leu 105 Leu Val Glu Thr Asp 185 Asp Phe Thr Asn Thr 265 Lys Asn Leu Ile 10 Tyr Lys Arg Val Leu 90 Asn Val Tyr Met Ala 170 Ile Asn Ala Pro Lys 250 Ile Lys Ala Phe Val 330 Lys I~de t Vlal Leu 75 Lys Asp Ala Val Glu 155 Ser Val Met Ile Leu 235 Ala Asp Ala Ala Phe 315 Asp Lys I Ser Arg Pro Met Gly Thr Val 140 Pro Val Tyr Lys Val 220 Ile Asp Glu Glu Leu 300 Ile 4 Glu 4 ys ksp T Ser 31u Arg Lys Leu 125 Thr Leu Arg Gly Tyr 205 Asp Ile Glu Lys Asn 285 Sen Asp Phe /al jal ;7al Sen His Ile 110 Ala Val Tyr Asp Thr 190 Ser Glu Sen Val Asn 270 Leu His Lys Thr Leu Glu I Giu I Phe Phe Ala 4 Val.
Asn.
Gin Asp.
175 Asn Leu Va1 Gly Ala 255 Arg Phe His Asp Gly 335 kla Leu Lys Ala Asp Glu Ala Asp Phe 160 Asp Asn Glu Asp Pro 240 Lys Ala Gly Leu Tyr 320 Arg Thr Thr Met Ile Lys Ala Ile Ile Gly Lys Ile Ile Gly Gin Ala Leu Val Sen Lys Asn Asn 325 Gly Arg 340 Ala Arg Phe Ser Glu Gly Leu His Gin Ala Leu Glu 345 350 INFORMATION FOR SEQ ID NO:1760: 1298 SEQUENCE CHARACTERISTICS: LENGTH: 365 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .365 (xi) SEQUENCE DESCRIPTION: SEQ ID N0:1760 Lys Leu Phe Leu Lys Pro Leu Lys Glu Thr Ser Leu Ala Leu Val Gly 1 S 10 Val Ala Lys Asn Ile Lys Ile Val Ala Leu Lys Ala Gly Leu Lys Ang .20 25 Ala Tyr Leu Pro Asn Arg Ser Leu Ile Phe Phe Leu Ile Lys Arg Tyr 9..Leu Arg Phe Asp Lys Ser Gin Pro Phe Ile Ser Ile Thr Ala Leu Leu s0 55 Ala Phe Phe Gly Val Ala Val Gly Val Met Val Leu Ile Val Ala Met 70 75 *Ala Ile Met Asn Gly Met Sen Lys Giu Phe Giu Lys Lys Leu Phe Val 90 Met Asn Tyn Pro Leu Thr Leu Tyr Thr Thr Sen Pro Tyr Gly Ile Sen 9100 105 110 Giu Giu Val Val Gin Ala Leu Giu Lys Lys Phe Pro Asn Leu Leu Phe :115 120 125 Ser Pro Tyr Leu Gin Thr Gin Sen Pro Ile Lys Sen Ala His Ser Met 130 135 140 Asn Gly Gly Val Val Phe Gly Val Asp Phe Ser Lys Giu Arg His Ile Asn Glu Val Leu Asn Asp Ala Leu Lys Asn Ile Asn Giu Asn Asp Leu 165 170 175 Phe Lys Asn Pro Phe Asn Leu Ile Val Gly Lys Ser Leu Arg Tyr Ser .9*180 185 190 Leu Asn Leu Asp Leu Asn Gin Lys Ala Asp Leu Phe Phe Thr Giu Leu 195 200 205 Giu Pro Thr Gly Leu Thr Leu Ser Pro Ile Met Lys Arg Phe Thr Ile 210 215 220 Lys Gly Asp Phe Asp Ser Gly Leu Lys Ser Tyr Asp Met Ser Tyr Met 225 230 235 240 Tyr Ala Sen Leu Gin Ala Ile Ser Ala Ile Ang Arg Leu Pro Leu Gly 245 250 255 Leu Tyr Asp Gly Val His Val Tyr Ser Lys Thr Pro Met Lys Asp Ile 260 265 270 Giu Lys Leu Arg Asn Ala Leu Lys Thr Ile Asn His His Gly Ile Gly 275 280 285 Ile Glu Gly Trp Trp Gin Gin Asn Gly Asn Phe Phe Ser Ala Met Giu 290 295 300 Leu Glu Lys Arg Ala Leu Phe Ile Val Leu Met Leu Ile Ile Leu Met 305 310 315 320 Ala Ser Leu Asn Ile Ile Ser Ser Leu Leu Met Val Val Met Asn Arg 325 330 335' Arg Lys Glu Ile Ala Leu Leu Phe Sen Met Gly Ser Ser Gin Lys Glu 340 345 350 Ile Gin Lys Thr Phe Phe Tyr Leu Gly Asn Ile Ile Ser 355 360 365 1299 INFORMATION FOR SEQ ID NO:1761: SEQUENCE CHARACTERISTICS: LENGTH: 354 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .354 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:176i Arg Giy Val Ser Ile Lys Giu Glu Ser Gin Thr Leu Ala Asp Ile Thr 1 5 10 Phe Gin Asn Tyr Phe Arg Met Phe Ser Lys Leu Ser Gly Met Thr Giy 25 *.Thr Ala Gin Thr Giu Ala Thr Giu Phe Leu Giu Ile Tyr Asn Leu Giu 40 Val Val Ser Ile Pro Thr Asn Leu Ala Ile Lys Arg Lys Asp Leu Asn 55 Asp Leu Ile Tyr Lys Ser Giu Lys Giu Lys Phe Asp Ala Val Ile Leu 70 75 *Lys Ile Lys Giu Leu His Asp Lys Gly Gin Pro Val Leu Val Giy Thr 90 4Ala Ser Ile Giu Lys Ser Giu Thr Leu His Ala Leu Leu Lys Lys Giu 100 10S 110 Arg Ile Pro His Thr Val Leu Asn Ala Lys Gin His Thr Lys Giu Ala 115 120 125 Giu Ile Ile Lys Asp Ala Gly Leu Lys Gly Ala Val Thr Ile Aia Thr 130 135 140 Msn Met Ala Gly Arg Gly Val Asp Ile Lys Leu Thr Asp Giu Val Lys 145 150 155 160 Glu Leu Gly Gly Leu Tyr Ile Ile Gly Thr Glu Arg His Giu Ser Arg Arg Ile Asp Asn Gin Leu Arg Gly Arg Ser Gly Arg Gin Gly Asp Pro 180 185 190 Gly Val Ser Gln Phe Tyr Leu Ser Leu Giu Asp Msn Leu Leu Arg Ile 195 200 205 Phe Gly Ser Asp Arg Thr Lys Gly Val Met Giu Lys Leu Gly Pro Lys 210 215 220 Asp Gly Giu His Ile Glu Phe Lys Leu Val Thr Arg Ala Val Giu Asn 225 230 235 240 Aia Gin Lys Lys Val Giu Asn Leu His Phe Asp Ser Arg Lys His Leu 245 250 255 Leu Glu Tyr Asp Asp Val Ala Asn Glu Gin Arg Thr Ser Val Tyr Asn 260 265 270 Leu Arg Asp Giu Leu Leu Asp Ile Msn Tyr Asp Ile Ser Ala Lys Ile 275 280 285 Ala Giu Asn Arg Giu Tyr Aia Leu Asn Gin Ile Phe Ser Lys Leu Lys 290 295 300 Ala Phe Asp His Gln Asn Leu Ser Glu Giu Giu Leu Leu Gly Leu Lys 305 310 315 320 Msn Ile Leu Lys Giu Asp Phe Msn Ala Ser Val Giu Leu Giu Asp Leu 325 330 335 Giu Lys Ala Ser Pro, le Giu Ile Phe Val Ala Giu Lys Leu Lys Ser 1300 340 345 350 Gly Leu INFORMATION FOR SEQ ID NO:1762: SEQUENCE CHARACTERISTICS: LENGTH: 107 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .107 o..
SEQUENCE DESCRIPTION: SEQ ID NO:1762 **:go Met Gin Lys Phe Phe Ser Arg Phe Arg Arg Trp Ala Leu Pro Phe Tyr 1 5 10 Phe Val Ser Ala Leu Ala Ala Ile Asp Ile Asp Glu Val Thr Glu Ala 25 *Gin Ala Asn Ser Ile Lys Leu Ser Asp Gln Leu Val Sen Leu Ser Asp 40 Lys Leu Leu Glu Lys Ala Val Asp Arg Gly Ang Asn Thr Asp His Leu *50 55 Lys Asp Leu Asn Asp Leu His Giu Lys Ile Lys His Leu Arg Leu Ile 70 75 Leu Glu Pro Lys Pro Lys Gly Lys Glu Asp Ser Pro Asn Leu Gly Gly 90 Asn Lys Asp Met Lys Thr Val Glu Ile Gly Ser goof 100 105 see,(2) INFORMATION FOR SEQ ID NO:1763: Ci) SEQUENCE CHARACTERISTICS: (A LENGTH: 275 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .275 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1763 Lys Asn Gin Ile Leu Gin Ile Pro Leu Leu Pro Pro Pro Pro Asn Asn 1 5 10 Giu Glu Leu Leu Lys Sen Ile Thr Asp Leu Lys Asp Ang Leu Lys Lys 25 1301 Leu Glu Asp Leu Lys Leu Glu Asp Phe Glu Pro Leu Arg Lys Leu Ser 40 His Phe Ile Val Ile Gly Asn Leu Phe Gly Lys Ser Ser Asn Asp Thr so 55 Gin Glu Asn Pro Lys Asp Ala Leu Lys Ser Thr Asn Phe His Glu Lys 70 75 His Thr Lys Pro Thr Glu Thr Thr Glu Leu Val Glu Glu Asri Lys Ala 90 Leu Thr Thr Glu Lys Glu Arg Leu Glu Arg Glu Asn Lys Asn Leu Thr 100 105 110 Ala Asp Lys Glu Asn Leu Thr Lys Glu Lys Thr Glu Leu Gin Lys Gin 115 120 125 Val Asn Glu Leu Lys Asn Ser Lys Gin Val Leu Glu Asn Glu Lys Ala 130 135 140 Asp Trp Leu Arg Glu Lys Glu Asn Leu Thr Lys Asp Arg Glu Asn Leu 145 150 155 160 Thr Lys Giu Lys Thr Glu Leu Thr Glu Lys Asn Lys Val Leu Thr Thr 165 170 175; Glu Lys Glu Arg Leu Ala Thr Glu Lys Glu Asn Leu Thr Lys Glu Lys 180 185 190 Thr Glu Ser Gin Lys Gin Val Asn Glu Leu Lys Asn Ser Lys Gin Val .195 200 205 Leu Glu Asn Glu Lys Ala Asp Leu Thr Asn Glu Asn Thr Lys Leu Lys 210 215 220 Thr Asp Lys Thr Asp Leu Thr Glu Lys Asn Gin Arg Leu Thr Thr Giu 225 230 235 240 Lys Thr Glu Leu Asn Asn Lys Ile Thr Gly Leu Ala Thr Glu Lys Glu 245 250 255 Arg Leu Ala Ala Asp Lys Glu Asn Leu Thr Lys Glu Ser Arg Gin Arg 260 265 270 Lys Pro Asn 0:0 275 06 INFORMATION FOR SEQ ID NO:1764: 0 4 00 0Ci) SEQUENCE CHARACTERISTICS: 0 LENGTH: 130 amino acids TYPE: amino acid TOPOLOGY: linear MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .130 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1764 Ala Leu Sen Asn Cys Leu Ser Leu Ser Val Ang Arg Trp, Phe Sen Phe 1 5 10 is Ser Lys Leu Val His Arg Phe Ser Arg Asn Pro Cys Ala Sen Cys Asn 25 Arg Ala Arg Sen Cys Ser Arg Leu Sen Arg Sen Leu Val Ser Ala Val 40 Thr TrP Trp Leu Ser Leu Sen Phe Ser Val Val Sen Ala Leu Phe Sen so 55 Leu Val Sen Ser Val Ile Leu Trp Val Sen Ser Val Phe Sen Leu Phe 70 75 Sen Leu Ser Phe Sen Val Val Asn Ser Leu Phe Sen Sen Val Sen Ang 1302 90 Ser Leu Ala Ala Asn Lys Arg Val Phe Ser Leu Ala Lys Met Ser Phe 100 105 110 Ser Val Phe Ser Ser Ala Phe Ser Leu Val Ser Leu Leu Leu Phe Cys 115 120 125 His Asn 130 INFORMATION FOR SEQ ID NO:1765: SEQUENCE CHARACTERISTICS: LENGTH: 327 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc -feature LOCATION 1 .327 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1765 Met Gly Thr Lou Ile Giu Lys Trp Phe Gly Phe Sen Gln Ile Arg Glu 1 5 10 Glu Leu Glu Ala Arg Ile Son Glu Leu Giu Asp Giu Asn Thr Giu Lou 55520 25 Lou Arg Glu Arg Glu Tyr Leu Ala Ala Giu Thr Son Glu Lou Lys Asp 40 Ala Asn Asp Gin Leu Arg Gin Lys Asn Asp Lys Lou Phe Ile Thr Lys so 55 Asp Lys Leu Thr Lys Glu Asn Thr Glu Leu Phe Ala Giu Asn Giu Sen 70 75' Lou Sen Val Lys Ile Ser Gly Leu, Giu His Ser Asn Asp Gin Leu Trp 90 Gin Asn Asn Asn Lys Lou Thr Lys Glu Lys Ala Giu Leu Lys Thr Glu 100 105 110 Lys Asp Ile Lou Ala Lys Glu Asn Thr Arg Lou Leu Ala Ala Arg Asp 115 120 125 Arg Leu Thr Giu Glu Lys Arg Giu Lou Thr Thr Glu Lys Giu Arg Lou 130 135 140 Lys Ang Giu Asn Thr Glu Leu Thr His Lys Ile Thr Glu Leu Thr Lys 145 150 155 160 Glu Asn Lys Ala Leu Thr Thr Giu Asn Asp Lys Leu Asn His Gin Val 165 170 175 Thx Ala Lou Thr Asn Glu -Arg Asp Ser Lou Glu Gin Glu Ang Ala Arg 180 185 190 Lou Gin Asp Ala His Gly Pho Leu Giu Lys Ang Cys Thr Asn Leu Glu 195 200 205 Lys Giu Asn Gin Arg Leu Thr Asp Lys Leu Lys Gin Leu Giu Ser Ala 210 215 220 Gin Lys Sen Lou Glu Asn Thr Asn Asn Gin Leu Ang Gin Ala Leu Glu 225 230 235 240 Asn Ser Asn Val Gin Lou Ala Gin Ala Lys Giu Lys Ile Ala Ile Glu 245 250 255 Lys Ser Glu Lou Glu Arg Glu Ile Ala Arg Leu Lys Sen Lou Glu Gly 260 265 270 Met Glu Ala Lys Sen Asp Lou Asp Lou His Asn Ang Arg Leu Ala Ser 275 280 285 Ala Ile 305 Leu 1303 Asn Giu Asp Leu Lys Arg Gin Asn Arg Lys Leu Glu Giu Glu Asn 290 295 300 Ala Leu Lys Glu Arg Val Asp Giy Leu Asn Giu Gin Leu Ser Lys 310 315 320 Gin Pro Gin Lys Pro Gin 325
I;
INFORMATION FOR SEQ ID NO:1766: SEQUENCE CHARACTERISTICS: LENGTH: 93 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .93 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1766 Phe Lys Thr Ile Giu Arg Asn Asp Phe Lys Leu Asn 1 5 10 Ile Leu Gin Asn Lys Giy Tyr Lys Met Lys Thr Ile 20 25 Met Ile Gly Thr Leu Gly Ala Leu Lou Leu Sen Gly 40 Asp Ala Gin Arg Phe Ala Cys Leu Pro Lys Asp His 55 Ala Ser Thr Lys Lys Giu Ala Gin Tlyr Ile Pro Lys 65 70 Pro Tyr Ser Sen Asn Leu Asn His Tnp Asp Ser Thr Gly Leu Thr Lys Asn Gly Cys Sen Ser Ser Ser Lys Gly Phe Phe Phe INFORMATION FOR SEQ ID NO:i767: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 303 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: -YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: WA NAME/KEY: misc-feature LOCATION .303 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1767 Sen Lou Asn Lys Gly Leu Ala Leu Phe Lou Val Lys Lys Ile dly Val 10 Val Ile Met Ilie Leu Val Cys Phe Leu Ala Cys Ser Gin GJlu Ser Phe 1304 25 Ile Lys Met Gin Lys Lys Ala Gin Glu Gin Giu Asn Asp Gly Ser Lys 40 Arg Pro Ser Tyr Val Asp Ser Asp Tyr Giu Val Phe Ser Giu Thr Ile so 55 Phe Leu Gin Asn Met Val Ty'r Gin Pro Ile Giu Giu Arg Asn Ala Phe 70 75 Phe Gin Leu Thr Lys Asp Giu Asp Asn Ser Phe Asn Pro Giu Asn Ser 90 Val Ile Leu Leu Asn Giu Pro Ser Asp Asn Ser Glu Lys Asn Leu Leu 100 105 110 Ser Tyr Pro Asn Asp Pro Asn Asn Asn Glu Asp Asn Ala Asn Asn Ser 115 120 125 Gin Lys Asn Pro Phe Leu Tyr Lys Pro Lys Arg Lys Thr Lys Asn Pro 130 135 140 Lys Leu Ile Glu Tyr Ser Gin Gin Asp Phe Tyr Pro Leu Lys Asn Giy 145 150 155 160 Asp Ile Ile Met Ser Lys Giu Gly Asp Gin Trp Leu Ile Giu Ile Gin 165 170 175 Ser Lys Aia Leu Lys Arg Phe Leu Lys Asp Gin Asn Asp Lys Asp Arg 180 185 190 Gin Ile Gin Thr Phe Thr Phe Asn Asp Thr Lys Thr Gin Ile Ala Gin 195 200 205 I *le Lys Gly Lys Ile Ser Ser Tyr Vai Tyr Thr Thr Asn Asn Gly Ser 210 215 220 *Leu Ser Leu Arg Pro Phe Tyr Giu Ser Phe Leu Leu Glu Lys Lys Ser 225 230 235 240 *Asp Asn Val Tyr Thr Ile Glu Asn Lys Ala Leu Asp Thr Met Giu Ile erLs y Gn245 250 255 SerLysCysGinMet Val Leu Lys Lys His Ser Thr Asp Lys Leu Asp 260 265 270 Ser Gin His Lys Ala Ile Ser Ile Asp Leu Asp Phe Lys Lys Glu Arg 275 280 285 *Phe Lys Ser Asp Thr Giu Leu Phe Leu Giu Cys Leu Lys Giu Ser 290 295 300 INFORMATION FOR SEQ ID NO:1768: SEQUENCE CHARACTERISTICS: LENGTH. 121 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NA1ME/KEY: -misc-feature LOCATION .121 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1768 Ala Trp Leu Lys Ser Arg Val Leu Met Lys Arg Leu Ala Val Ala Leu 1 S 10 Ile Leu Val Leu Gly Val Val Trp Gly Lys Ser Leu Pro Lys Trp Ala 25 Lys Asp Cys Sen Lys Glu Met Arg Ile Giu Lys Thr Gin Thr Lys'Asp 40 Giu Lys Ile Leu Val Cys Gly Met Ser Asp Ile Leu Leu Ser Asp Met 55 M 1111110 M 1305 Asp Tyr Ser Leu Ser Ser Ala Arg Gin Asn Ala Leu Glu Lys Val Met 70 7S Giu Ala Phe Lys Gly Asp Arg Ile Glu Ile Lys Ala Gly Glu Leu Lys 90 Ala Thr Phe Ile Asp Thr Asp Lys Val Tyr Val Leu Leu Arg Ile Thr 100 105 110 Lys Lys His Val Ala Leu Met Asn Glu 115 120 INFORMATION FOR SEQ ID NO:1769: SEQUENCE CHARACTERISTICS: LENGTH: 306 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-.feature LOCATION .306 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1769 Giy Leu Ile Met Lys Lys Ile Ile Leu Ala Cys Leu Val Ala Phe Val 1 5 10 is Gly Ala Asn Leu Sen Ala Giu Pro Lys Trp Tyr Sen Lys Ala Tyr Asn 25 00 Lys Thr Asn Ala Gin Lys Gly Tyr Leu Tyr Gly Ser Gly Ser Ala Thr 40 Ser Lys Giu Ala Ser Lys Gin Lys Ala Leu Ala Asp Leu Val Ala Sen 55 Ile Ser Val Val Val Asn Ser Gin Ile His Ile Gin Lys Ser Arg Val 70 75. Asp Asn Lys Leu Lys Ser Ser Asp Ser Gin Thn Ile Asn Leu Lys Thr 90 Asp Asp Leu Giu Leu Asn Asn Val Giu Ile Val Asn Gin Glu Ala Gin 100 105 110 Lys Gly Ile Tyr Tyr Thn Arg Val Arg Ile Asn Gin Asn Leu Phe Leu 115 120 125 Gin Gly Leu Arg Asp Lys Tyr Asn Ala Leu Tyr Gly Gin Phe Ser Thr 130 135 140 Leu Met Pro Lys Val Cys Lys Gly Val Phe Tyr Lys Gin Ser Lys Sen 145 150 155 160 Met Gly Asp Leu Leu Ala Lys Ala Ala Pro Met Giu Arg Ile Leu Lys 165 170 175 Ala Tyr Sen Val Pro Val Ser Ser Leu Giu Asn Tyr Giu Lys Ile Tyr 180 185 190 Tyr Gin Asn Ala Phe Lys Pro Lys Val Arg Ile Ala Phe Asp Asp Asn 195 200 205 Sen Asp Thr Glu Ile Lys Asn Ala Leu Met Sen Ala Tyr Ala Arg Val 210 215 220 Leu Thr Pro Ser Asp Giu Giu Lys Leu Tyr Gin Ile Lys Asn Giu Val 225 230 235 240 Phe Thr Asp Ser Ala Asn Gly Ile Thn Ag Ile Arg Val Ile Ile Ser 245 250 255* Ala Ser Asp Cys Gin Gly Thr Pro Val Leu Asn Arg Sen Leu Giu Val 260 265 270 Asp Glu Lys Asn Lys Asn Phe Ala Ile Thn Arg Leu Gin Ser Leu Leu 1306 275 280 285 Tyr Lys Glu Leu Lys dly Tyr Ala Asn Lys Glu Gly Gin Gly Asn Thr 290 295 300 Gly Leu 305 INFORMATION FOR SEQ ID NO:1770: SEQUENCE CHARACTERISTICS: LENGTH: 339 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 339 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1770 Pro Gin Arg Val Val Phe Arg Val Arg Phe Leu Leu Ala Ile Pro Gin *1 5 10 Ile Leu Val Gly Leu Arg Ile Ala Val Val Met Leu Val Ala Met Ala 25 Gly Ile Gly Ala Leu Ile Gly Ala Gly Gly Leu Gly Gin Ala Ile Phe 40 Ang Gly Leu Asn Thr Gin Asn Thr Th Ile Lou Vai Ala Gly Ser Phe 55 Ile Ile Ala Leu Phe Sen Val Leu Ala Asp Gin Phe Val Ser Val Phe 70 75 Gin His Giu Asn Ala Leu Gin Arg Leu Phe Ser Gin Asn Ala Thr Gin 90 Lys Gin Lys Arg Ang Val Tyr Val Asn Leu Ala Val Phe Leu Phe Leu 100 105 110 ::;Leu Leu Ala Ser Ala Leu Tnp Lou Ile Pro Arg Ser Ala Ile Giu Glu 115 120 125 Lys Pro Leu Val Val Ala Thr Lys Pro Ser Ser Giu Gin Tyr Ile Lou 130 135 140 Gly Giu Ile Leu Ser Leu Leu Leu Giu Lys His His Ile Pro Ile Lys 145 150 155 160 Arg Ala Phe Gly Ile Gly Gly Gly Thr Met Asn Ile His Pro Aia Lou 165 170 175 Ile Arg Gly Asp Phe Asp Leu Tyr Val Glu Tyr Thr Gly Thr Ala Trp 180 185 190 Val Asn Thr Leu Lys Asn Pro Leu Thr Gin Lys Val Asp Phe Glu Thr 195 200 205 Ile Lys Lys Arg Tyr Glu Lys Giu Phe Asn Leu Lou Trp Val Gly Leu 210 215 220 Leu Gly Phe Asn Asn Thr Tyr Sen Leu Ala Ile Sen Lys Glu Asp Ala 225 230 235 240 Gin Lys Tyr Ala Ile Glu Thr Phe Ser Asp Leu Ala Phe His Sen Pro 245 250 255 Asn Phe Asp Phe Gly Ala Glu Phe Asp Phe Phe Giu Arg Glu Asp Ala 260 265 270 Phe Lys Gly Leu Ile Lys Ala Tyr Arg Phe His Phe Arg Ser Leu His 275 280 285 Giu Met Asp Ile Asn Leu Arg Tyr Lys Ser Phe Giu Sen His Lys Ile 290 295 300 1307 Asn Ala Leu Asp Val Phe Thr Thr Asp Ala Gin Ile Lys Glu Leu Asp 305 310 315 320 Leu Lys Val Leu Lys Asp Asp Lys Gly Phe Phe Pro Asn Tyr Gin Ala 325 330 335 Gly Ile Val INFORMATION FOR SEQ ID NO:1771: SEQUENCE CHARACTERISTICS: LENGTH: 144 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...144 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1771 Gly Ala Lys Met Lys Lys Ile Gly Leu Ser Leu Cys Leu Val Leu Ser 1 5 10 SLeu Gly Phe Leu Lys Ala His Glu Val Ser Ala Glu Glu Ile Ala Asp 20 25 Ile Phe Tyr Lys Leu Asn Ala Lys Glu Pro Lys Met Lys Ile Asn His 35 40 Thr Lys Gly Phe Cys Ala Lys Gly Val Phe Leu Pro Asn Pro Gin Ala 55 Arg Glu Asp Leu Glu Val Pro Leu Leu Asn Glu Lys Glu Ile Pro Ala 70 75 Ser Val Arg Tyr Ser Leu Gly Gly Val Ala Met Asp Asp Lys Ser Lys 90 Val Arg Gly Met Ala Leu Lys Leu Glu Asn Gin Asn Ala Ser Trp Thr 00 105 110 Met Val Met Leu Asn Thr Glu Ile Asn Phe Ala Lys Asn Pro Glu Glu 115 120 125 Phe Ala Gin Phe Phe Glu Met Arg Leu Pro Lys Asn Gly Gin Gly Arg 130 135 140 INFORMATION FOR SEQ ID NO:1772: SEQUENCE CHARACTERISTICS: LENGTH: 528 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...528 1308 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1772 His Giu Phe Leu Ala Ile Asn Giu Leu Met Phe Asp Val Phe Lou Pro 1. 5 10 Ser Arg Leu Lys Gin Lys Glu Leu Leu Glu Lys Ile Glu Val Ile Gin 25 Lys Phe Phe Pro Asn Phe Pro Lys Giu Thr Leu Leu Asn Asn Tyr Gin 40 Lys Glu Asn Ser Leu Tyr Asn His Asn Lou Ile Lys Val Val Gly Phe s0 55 Ile Pro Tyr Ala Thr Met Gin Ser Lou Tyr Thr Lys Leu Ile Gin Thr 70 75 Gin Gly Ile Phe Val Arg Pro Leu Asp Lys Arg Tyr Tyr Pro Asn Asn 90 Ala Lou Ala Ser His Vai Lou Giy Tyr Val Giy Vai Aia Ser Leu Gin 100 105 1120 Asp Leu Lys Asp Asp Giu Glu Asn Gin Tyr Ser Gin Ile Vai Gly Lys 115 1.20 125 Thr Gly Ile Glu Lys Giu Tyr Asn Lys Phe Lou Gin Gly Lys Vai Giy 130 2.35 140 Tyr Lys Ile Ile His Val Asn Ala Leu Asn Gin Giu Leu Ala Thr Leu 1 245 2.50 2.55 160 Giu Val Vai Pro Pro Arg Ser Asn Asn His Ser Gin Lou Ser Leu Asp *165 170 175 Lys Arg Pho Gin Lys Giu Aia His Lys Leu Pho Val Asn Lys Arg Giy 180 .185 2.90 Pro Ile Lou Val Met Asp Ala Giu Asn Giy Glu Lou Lou Val Ala Giy 195 200 205 Ser Tyr Pro Giu Tyr Asn Lou Asn Asp Phe Val Giy Gly Ile Ser Gin *210 22.5 220 Asp Lys Trp Gin Lys Lou Gin Asp Asp Ile Tyr Asn Pro Lou Leu Asn *225 230 235 240 Arg Phe Aia Asa Ala Leu Tyr Pro Pro Gly Ser Vai Val Lys Met Giy 245 250 255 Vai Giy Lou Ser Phe Lou Giu Asn Lou His Ile Thr Glu Asn Thr Thr *260 265 270 Ile Pro Thr Pro Pro Phe Ile Giu Val Giy Lys Arg Lys Phe Arg Asp 275 280 285 Trp Lys Lys Thr Giy His Gly Asn Ser Asn Leu Tyr Lys Ala Ile Arg *Gu290 295 300 GuSer Val Asp Val Tyr Phe Tyr Lys Phe Gly Leu Giu Ile Ser Ile 305 310 315 320 Giu Lys Lou Ser Lys Thr Leu Arg Giu Val Gly Phe Giy Giu Lys Thr 325 330 335 Gly Vai Asp Lou Pro Asn Giu Phe Val Gly Ile Val Pro Asp Asn Lou 340 345 350 Trp Lys Leu Lys Arg Phe Asn Gin Asp Trp, Arg Val Gly Asp Thr Lou 355 360 365 Ile Thr Ala Ile Gly Gin Gly Ser Phe Lou Ala Thr Pro Leu Gin Val 370 375 380 Leu Aia Tyr Thr Gly Le -Ile Ala Thr Gly Lys Lou Aia Thr Pro His 385 390 395 400 Phe Ala Ile His Asn Gin Gin Pro Lou Lys Asp Pro Lou Asn Ser Phe 405 410 415 Gin Lys Lys Lys Lou Gin Ala Leu Arg Val Gly Met Tyr Glu Val Cys 420 425 430 Asn His Lys Asp Gly Thr Ala Tyr His Ser Thr Arg Gly Ser Lys Val 435 440 445 Thr Lou Ala Cys Lys Thr Gly Thr Ala Gin Val Val Gu Ile Ala Gin 450 455 460 Asn Ile Val Asn Arg Met Lys Giu Lys Asp Met Giu Tyr Phe His Arg 465 470 475 480 Ser His Ala Trp 485 49049 Tyr Clu Lys Pro Lys Tyr 495 1309 Ala Ile Thr Ile Leu Val Giu His Gly Giu Gly Gly Ser Lys Leu Gly 500 505 510 Gly Leu Leu Val Lys Met Ser As!' Lys Leu Tyr Glu Leu Gly Tyr Leu 515 520 525 INFORMATION FOR SEQ ID NO:1773: SEQUENCE CHARACTERISTICS: LENGTH: 280 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .280 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i773 ape Ile Asn Phe Val Asn Lys Gly Val Phe Met Asn Ile Phe Lys Arg Ile 1 5 10 1 Sle Cys Val Thr Ala Ile Val Leu Gly Phe Phe Asn Leu Leu Asp Ala 25 Lys His His Lys Giu Lys Lys Giu Asp His Lys Ile Thr Arg Giu Leu 40 *Lys Val Gly Ala Asn Pro Val Pro His Ala Gin Ile Leu Gin Ser Val 55 Val Asp Asp Leu Lys Giu Lys Gly Ile Lys Leu Val Ile Val Sen Phe 70 75 *Thr Asp Tyr Val Leu Pro Asn Leu Ala Leu Asn Asp Gly Ser Leu Asp 90 Ala Asn Tyr Phe Gin His Arg Pro Tyr Leu Asp Arg Phe Asn Leu Asp 100 105 110 Arg Lys Met His Leu Val Gly Leu Ala Asn Ile His Val Giu Pro Leu 115 120 125 Arg Phe Tyr Ser Gin Lys Ile Thr Asp Ile Lys Asn Leu Lys Lys Giy 130 135 140 Ser Val Ile Ala Val Pro Asn Asp Pro Ala Asn Gin Gly Arg Ala Leu 145 150 155 160 Ile Leu Leu His Lys Gin Gly Leu Ile Ala Leu Lys Asp Pro Ser Asn 165 170 175 Leu Tyr Ala Thr Giu Phe Asp Ile Val Lys Asn Pro Tyr Asn Ile Lys 180 185 190 Ile Lys Pro Leu Giu Ala Ala Leu Leu Pro Lys Val Leu Gly Asp Val 195 200 205 Asp Gly Ala Ile Ile Thr Gly Asn Tyr Ala Leu Gin Ala Lys Leu Thr 210 215 220 Gly Ala Leu Phe Ser Glu Asp Lys Asp Ser Pro Tyr Ala Asn Leu Val 225 230 235 240 Ala Ser Arg Giu Asp Asn Ala Gin Asp Giu Ala Ile Lys Ala Leu Ile 245 250 255 Giu Ala Leu Gin Sen Giu Lys Thr Arg Lys Phe Ile Leu Asp Thr Tyr 260 .265 270 Lys Gly Ala Ile Ile Pro Ala Phe 275 280 INFORMATION FOR SEQ ID NO:i774: 1310 SEQUENCE CHARACTERISTICS: LENGTH: 326 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .326 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1774 9 9 9 a S 9* *9 9 Met Phe Pro Ala Gly 65 Leu Ala Ala Ang Leu 145 Ile Val Pro Arg CGiy 225 Sen Leu Asn Gin Gin 305 Gin Val Val1 Thr Ser Leu Leu Phe Val1 130 G1ly Gly Ala Ser Pro 210 His Gin Ala Ser Leu 290 Ile Asn Met Ile Thr Lys Gin Ser Tyr Gin Arg Phe Phe Ala 35 Val1 Leu Leu Ala Ala 115 Ala Sen Gin Thr Arg 195 Leu Phe Phe Asp Arg 275 Leu Phe Glu Sen 20 Leu Gly Pro Phe Trp 100 His Pro Ser Ile Leu 180 Asn Leu Thr Sen Val 260 Lys Leu Leu Gly Sen Ala Ser Asp Met Ile Met Leu Phe Ala Phe Trp Ile Phe Msn Lys 135 Ala Met 150 Asp Trp Met Leu Gly Thr Gly Ile 215 Tyr Sen 230 Asp Ile Gly-Ser Ile Ala Val Phe 295 Gly Ile 310 His Phe Ile 40 Thr Leu Leu Val Trp 120 Lys Ile Arg Leu Leu 200 Tyr Tyr Thr Phe Phe 280 Lys Ile Ala Ala Ser Phe Leu 105 Sen Gin Leu Sen Met 185 Ala Leu Ile Thr Leu 265 Ala Msn Lou Thr Glu Val Giu His Arg Ser 125 Gly Leu Val Leu Ile 205 Met Ile Phe Leu Val 285 Val1 Gly Ile Thn Sen Leu Thr Ile Thr Lou 315 320 INFORMATION FOR SEQ ID NO:1775: 1311 SEQUENCE CHARACTERISTICS: LENGTH: 88 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...88 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1775 Lys Gly Ile Gin Lys Lys Gin Asn Leu Lys Glu Val Ala Leu Asp Ala 1 5 10 Phe Leu Pro Lys Ser Ile Asn Tyr Tyr His Phe Asn Gly Ser Leu Thr 20 25 Ala Pro Pro Cys Thr Glu Gly Val Ala Trp Phe Val Ile Glu Glu Pro 35 40 Leu Glu Val Ser Ala Lys Gin Leu Ala Glu Ile Lys Lys Arg Met Lys 50 55 Asn Ser Pro Asn Gin Arg Pro Val Gin Pro Asp Tyr Asn Thr Val Ile S. 65 70 75 S; Ile Lys Ser Ser Ala Glu Thr Arg S(2) INFORMATION FOR SEQ ID NO:1776: SEQUENCE CHARACTERISTICS: LENGTH: 150 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...150 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1776 Arg Ile Ile Lys Met Lys tys Thr Phe Leu Ile Ala Leu Ala Leu Thr 1 5 10 Ala Ser Leu Ile Gly Ala Glu Asn Thr Lys Trp Asp Tyr Lys Asn Lys 25 Glu Asn Gly Pro His Arg Trp Asp Lys Leu His Lys Asp Phe Glu Val 40 Cys Lys Ser Gly Lys Ser Gin Ser Pro Ile Asn Ile Glu His Tyr Tyr 55 His Thr Gin Asp Lys Ala Asp Leu Gin Phe Lys Tyr Ala Ala Ser Lys 70 75 Pro Lys Ala Val Phe Phe Thr His His Thr Leu Lys Ala Ser Phe Glu 90 Pro Thr Asn His Ile Asn Tyr Arg Gly His Asp Tyr Val Leu Asp Asn 1312 100 105 110 Val His Phe His Ala Pro Met Glu Phe Leu Ile Asn Asn Lys Thr Arg 115 120 125 Pro Leu Ser Ala His Phe Val His Lys Asp Ala Lys Gly Arg Leu Leu 130 135 140 Val Leu Ala Ile Gly Phe 145 150 INFORMATION FOR SEQ ID NO:1777: SEQUENCE CHARACTERISTICS: LENGTH: 383 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...383 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1777
S
*0 S S S. Met Pro Val Ile 1 Leu Ser Lys Asp Gly Asp Ala Gln Thr 145 Gln Val Asn Asn Ala 225 Asn His Lys Jal Ile 3ln 50 Asp Val Gin Arg Lys 130 Glu Glu Glu Thr His 210 Ile Gin Ser Glu Lys Met 35 Ile Tyr Thr Ser Asp 115 Thr Gin Lys Gin Gin 195 Asn Glu Thr Gin SLeu 275 Thr 20 Gly Lys Leu Ala Lys 100 Arg Glu Glu Gin Glu 180 Lys Gin Ile Pro Arg 260 Glu Arg 5 Ala Ile Lys Lys Ile Lys Ala Gin Lys Lys 165 Gin Asp Phe SGlu Ile 245 Gly Ser Lys Ala Ser Thr 70 Thr Glu Asn Glu Gin 150 Thr Gln Leu Phe Ala 230 Gin Ser Leu Val Leu Val Met Leu Ala Glu Lys Lys 25 Phe Trp Glu 40 Asp Trp Ile 55 His Pro Asn Ala Met Leu Val Ala Gin 105 Lys Ser Gly 120 Lys Gin Lys 135 Lys Thr Glu Ser Asn Ile rLys Thr Glu 185 Val Asn Lys 200 Ile Lys Lys 215 Glu Cys Lys Pro Lys His SLys Ala Gln 265 Pro Tyr Ser 10 Val Ala Cys Ser Met 90 Ala Ile Thr Gin Glu 170 Gln Ala Leu Thr Leu 250 Glu Phe Ile Gly Trp 75 Asn Gin Glu Glu Glu 155 Thr Glu Glu Gly Pro 235 Pro Leu Thr Lys Lys Asn Phe Val Lys Leu Gin 140 Lys Asn Lys Gln Ile 220 Lys Asn Ile Met Asn Asp Val Asn Cys Glu Glu 125 Glu Gin Asn Gin Asn 205 SLys Pro Ser Ala Ile 285 4et Val Ser Lys Ser Phe Ala 110 Gin Lys Lys Gln Lys 190 Cys Ala Thr Lys Tyr 270 Met Gly Ile Thr Ala Ala Glu Glu Gin Thr Ile 175 Thr Gin Gly Lys Gin 255 Leu Lys Ile Lys Ala Ile Asp Asn Glu Lys Glu 160 Lys Asn Glu Ile Thr 240 Pro Gin Gin Lys Ala Ala Lys Gln 280 1313 Val Asp Phe Tyr Arg Pro Ser Ser Ile Ala Tyr Leu Giu Leu Asp Pro 290 295 300 Arg Asp Phe Asn Ala Thr Giu Glu Trp Gin Lys Glu Asn Leo Lys Ile 305 310 315 320 Arg Ser Lys Ala Gin Ala Lys Met Leo Glu Met Arg Ser Leu Lys Pro 325 330 335 Asp Pro Gin Ala His Leu Ser Thr Ser Gin Ser Leu Lou Leo Val Gin 340 345 350 Lys Ile Phe Ala Asp Val Ser Lys Glu Ile Lys Val Val Ala Asn Thr 355 360 365 Giu Lys Lys Val Glu Lys Ala Gly Tyr Gly Tyr Ser Lys Arg Met 370 375 380 INFORMATION FOR SEQ ID NO:1778: SEQUENCE CHARACTERISTICS; LENGTH: 332 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAM~E/KEY: misc-feature LOCATION .332 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1778 Msn Lys Arg Lys Asn Ile Lys Giu Val Tyr Ala Gly Giu Ile Cys Ala 1 5 10 Phe Val Gly Leu Lys Asp Thr Lou Thr Gly Asp Thr Leo Cys Asp Giu 25 Lys Asn Ala Val Val Lou Glu Arg Met Giu Phe Pro Giu Pro Val Ile 40 His Ile Ala Vai Giu Pro Lys Thr Lys Ala Asp Gin Glu Lys Met Gly 55 :::Val Ala Lou Gly Lys Leu Ala Giu Glu Asp Pro Sen Phe Arg Val Met 70 75 Thn Gin Glu Giu Thr Gly Gin Thr Leu Ile Gly Gly Met Gly Giu Leo 90 His Leu Gu Ile Ile Val Asp Arg Leu Lys Arg Giu Phe Lys Val Glu 100 105 110 Ala Giu Ile Gly Gin Pro Gin Val Ala Phe Arg Glu Thr Ile Arg Sen 115 120 125 Ser Val Ser Lys Glu His Lys Tyr Ala Lys Gin Ser Gly Gly Ang Giy 130 135 140 Gin Tyr Gly His Val Phe Ile Lys Leo Giu Pro Lys Giu Pro Gly Ser 145 150 155 160 Gly Tyr Glu Phe Val Msn Gu Ile Ser Gly Gly Val Ile Pro Lys 010 165 170 175 Tyr Ile Pro Ala Vai Asp Lys Gly Ile Gin 010 Ala Met Gin Asn Gly 180 185 190 Val Leo Ala Gly Tyr Pro Val Val Asp Phe Lys Val Thn Leo Tyr Asp 195 200 205 Cly Ser Tyr His Asp Val Asp Ser Sen Glu Met Ala Phe Lys Ile Ala 210 215 220 Gly Sen Met Ala Phe Lys Glu Ala Ser Ang Ala Ala Msn Pro Val Leo 225 230 235 240 Lou Glu Pro Met Met Lys Val Giu Val Glu Val Pro Gbu Glu Tyn Met 1314 245 250 255 Gly Asp Val Ile Gly Asp Leu Asn Arg Arg Arg Gly Gin Ile Asn Ser 260 265 270 Met Asp Asp Arg Leu Gly Leu Lys Ile Val Asn Ala Phe Val Pro Leu 275 280 285 Val Glu Met Phe Gly Tyr Ser Thr Asp Leu Arg Ser Ala Thr Gin Gly 290 295 300 Arg Gly Thr Tyr Ser Met Glu Phe Asp His Tyr Gly Glu Val Pro Ser 305 310 315 320 Asn Ile Ala Lys Glu Ile Val Glu Lys Arg Lys Gly 325 330 INFORMATION FOR SEQ ID NO:1779: SEQUENCE CHARACTERISTICS: LENGTH: 109 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein o (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...109 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1779 Ser Lys Arg Ala Phe Ala Ser Ser Leu Val Ser Ser Lys Leu Phe Leu 1 5 10 Arg Asp Lys Glu Thr Arg Lys Arg Gly Leu Glu Thr Val Gly Gly Arg 25 Ile Ala Pro Thr Lys Asn Pro Phe Ser Phe Lys Lys Tyr Trp Ala Phe 35 40 Lys Arg Ala Gly Leu Phe Ser Asn Ser Arg Val Lys Asn Pro Val Gly 55 Val Leu Thr Pro Lys Val Ser Lys Ile Ile Cys Trp Cys Leu Leu Ser 65 70 75 Ser Phe Phe Asn Ser Cys Phe Cys Ala Ile Lys Tyr Ser Lys Trp Ala 90 Lys Val Lys Ala Val Ser Asn Arg Leu Lys Ala Val Val 100 105 INFORMATION FOR SEQ ID NO:1780: SEQUENCE CHARACTERISTICS: LENGTH: 438 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature 1315 LOCATION 438 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1780 Ile Arg Asn Ala Thr Met Phe Gly Asn Lys Gin Leu Gin Leu Gin Ile 1 5 10 Ser Gin Lys Asp Ser Giu Ile Ala Giu Leu Lys Lys Giu Val Asn Leu 25 Tyr Gin Ser Leu Leu Asn Leu Cys Leu His Giu Giy Phe Val Gly Ile 40 Lys Asn Asn Lys Val Val Phe Lys Ser Gly Asn Leu Ala Ser Leu Asn 55 Asn Leu Giu Giu Gin Ser Val His Phe Lys Giu Asn Ala Giu Ser Val 70 75 Asn Leu Gin Gly Val Ser Tyr Ser Leu Lys Ser Gin Asn Ile Asp Giy 90 Val Gin Tyr Phe Ser Leu Aia Lys Lys Thr Gly Gly Val Gly Giu Tyr 100 105 110 His Lys Asn Asp Leu Phe Lys Thr Phe Cys Thr Ser Leu Lys Giu Gly 115 120 125 Leu Giu Asn Ala Gin Giu Ser Met Gin Tyr Phe His Gin Giu Thr Gly 130 135 140 Leu Leu Leu Asn Ala Ala Lys Asn Gly Giu Giu His Ser Asn Glu Gly ,145 150 155 160 Leu Ile Thr Val Asn Lys Thr Gly Gin Asp Ile Glu Ser Leu Tyr Giu Ly e GnAn165 170 175 LysMetGlnAsnAla Thr Ser Leu Ala Asp Ser Leu Asn Gin Arg Ser ,..180 185 190 ***Asn Giu Ile Thr Gin Val Ile Ser'Leu Ile Asp Asp Ile Ala Glu Gin *195 200 205 Thr Asn Leu Leu Ala Leu Asn Ala Ala Ile Glu Ala Ala Arg Ala Gly 210 215 220 **Glu His Gly Arg Gly Phe Ala Val Val Ala Asp Glu Val Arg Lys Leu 225 230 235 240 SAla Glu Lys Thr Gin Lys Ala Thr Lys Glu Ile Ala Val Val Val Lys 245 250 255 Ser Met Gin Gin Giu Ala Asn Asp Ile Gin Thr Asn Thr His Asp Ile Sr ie260 265 270 *Asn SrIeVal Gly Ser Ile Lys Gly Asp Val Glu Giu Leu Lys Ser 275 280 285 Thr Val Lys Asn Asn Met Ile Val Ala Gin Aila Ala Lys T~yr Thr Ile 290 295 300 *Tyr Asn Ile Asn Asn Arg Val Phe Cys Gly Leu Ala Lys Leu Asp His ***305 310 315 320 Val Val Phe Lys Asn Asn Leu Tyr Giy Met Val Phe Giy Leu Asn Ser 325 330 335 Phe Asp Ile Thr Ser His Lys Ser Cys Arg Leu Gly Lys Trp Tyr Tyr 340 345 350 Giu Giy Ala Gly Lys Giu Asn Phe Ala Asn Thr Ser Giy Tyr Arg Ala 355 360 365 Leu Giu Ser His His Ala Ser Val His Ala Giu Ala Asri Asp Leu Val 370 375 380 Lys Ala Val Gin Giu Asp His Val Thr Asp Ser Lys Tyr Leu Giu His 385 390- 395 400 Lys Val His Leu Met Giu Asp Ser Ala Lys His Val Lys Giu Asn Ile 405 410 415 Asp Lys Met Phe Tyr Giu Lys Gin Asp Giu Leu Asn Lys Ile Ile Giu 420 425 430 Lys Ile Gin Lys Gly Giu 435 INFORMATION FOR SEQ ID NO:1781: SEQUENCE CHARACTERISTICS: 1316 LENGTH: 344 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .344 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i78i Giu Trp Leu Met Leu Lys Lys Ile Phe Tyr Gly Phe Ile Val Leu Phe 1 5 10 Leu Ile Ile Val Gly Leu Leu Ala Val Leu Val Ala Gin Val Trp Val 25 *Thr Thr Asp Lys Asp Ile Ala Lys Ile Lys Asp Tyr Arg Pro Ser Val 40 Ala Ser Gin Ile Leu Asp Arg Lys Gly Arg Leu Ile Ala Asn Ile Tyr sp 50 PeAr5h ApLys Giu PeAgh Tyr Ala Arg Phe Giu Giu Ile Pro Pro Arg 70 75 Phe Val Giu Ser Leu Leu Ala Val Giu Asp Thr Leu Phe Phe Giu His 90 Gly Gly Ile Asn Leu Asp Ala Vai Met Arg Ala Met Ile Lys Asn Ala 100 105 110 Lys Ser Gly Arg Tyr Thr Giu Gly Gly Ser Thr Leu Thr Gin Gin Leu 115 120 125 Val Lys Asn Met Val Leu Thr Arg Giu Lys Thr Leu Thr Arg Lys Leu 130 135 140 Lys Giu Ala Ilele Ser Ile Arg Ile Giu Lys Val Leu Ser Lys Giu 145 150 155 160 Giu Ile Leu Giu Arg Tyr Leu Asn Gin Thr Phe Phe Gly His Gly Tyr 165 170 175 Tyr Giy Val Lys Thr Ala Ser Leu Gly Tyr Phe Lys Lys Pro Leu Asp 180 185 190 Lys Leu Thr Leu Lys Giu Ile Thr Met Leu Val Ala Leu Pro Arg Ala 195 200 205 Pro Ser Phe Tyr Asp Pro Thr Lys Asn Leu Giu Phe Ser Leu Ser Arg :..210 215 220 Ala Asn Asp Ile Leu Arg Arg Leu Tyr Ser Leu Gly Trp Ile Ser Ser *225 230 235 240 Asn Giu Leu Lys Ser Ala Leu Asn Glu Val Pro Ile Val Tyr Asn Gin 245 250 255 *Tbr Ser Thr Gin Asn Ile Ala Pro Tyr Vai Val Asp Giu Val Leu Lys *260 265 270 Gin Leu Asp Gin Leu Asp Gly Leu Lys Thr Gin Gly Tyr Thr Ile Lys euhr275 280 285 Le le Asp Leu Asp Tyr Gin Arg Leu Ala Leu Giu Ser Leu Arg *he290 295 300 PeGly His Gin Lys Ile Leu Giu Lys Ile Ala Lys Giu Lys Pro Lys 305 310 31 320 Thr Asn Ala Ser Asn Asp Lys Asp Giu Asp Asn Leu Asn Ala Gin His 325 330 335 Asp Ser Tyr Arg Asn Glu His Arg 340 INFORMATION FOR SEQ ID NO:i782: 1317 SEQUENCE CHARACTERISTICS: LENGTH: 593 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...593 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1782 Ile Arg Thr Pro Met Asp Thr Ile Lys Ser Ile Pro Ile Arg 00.
I
Ile Thr Ile Phe Leu Ile Lys Thr Asn 145 Leu Val Lys Glu Phe Ile Leu Ile 130 Tyr 5 Leu TYr Lys Leu Phe Val, 35 Leu Ile Asp Tyr Ser Leu Leu Thr His 85 Ala Giu Gin 100 Thr Gin Val 115 Lys Leu Asn Val Ser Asn Ser Ile Val 55 Leu Phe
S
Ile Ile I Ala Ser Asp 225 Glu Asn Ile Gly Gln 305 Asn Ser Met Lys Met 210 Asn Thr Leu Ala Val 29C Glr Ly! Leu I Ile Lys 195 Gin Leu Lys Ile Leu 275 Gly 1 Leu s Tyr ?he i Phe 180 His Asn Leu Glu Phe 260 Phe Ala Gin Phe 3ly 165 Ala Ser Tyr Phe Leu 245 Thr Phe Ii( As Glr Phe S Lys Thr I Leu I 150 Ile I Thr Ala Leu Asn 230 Tyr Ile Leu Ala Leu 310 a Asn er sn le L35 ?he Leu Val Ser Tyr 215 Phe Let Ty3 Mel G1' 29 Se Ty Pro Leu 40 Val Pro Ser Ile Leu 120 His Phe Phe Prc Il( 20( Sei Mel 1 Asl Al t Va 28 y' Ty r Ph r Ph 1 Lys C 25 Pro S Asn L Thr L Gly 1 Asn 105 Asn I Asn Asn Ser Cys 185 Asp r Gly t Leu n Asn a Asp 265 1 Phe 0 r Ile Le Tyr e Cys er L eu L jeu L 7 :le I 00 [le 3 ?he I iy I Leu Ile 170 Ile Lys Leu Asn Phe 250 Val Ile Gln Gly Ile 330 0 ys Val Val Leu Ala Thr Phe Ser Ile
'C
1
S
L
L
!u Asn Ile L ?u Gin Lys H u Leu Trp G eu Ser Ser L le Thr Gin L he Giu Asn I 125 eu His Ile 140 in Arg Ile I 55 er Ile Tyr I 1 eu Ile Ser aeu Gin Asp I 205 ~sp Asn Gin 220 'he His His '35 7al Lys Val Leu Ile Thr lie Leu Ser 285 Ala Phe Ser 300 Lys Trp Phe 315 Leu Asp Tyr Lys Ile His Ser Lvs Leu eu Vi is T1 ly A eu G 9 1 eu A ,ys A Lrg P lie G .eu I ksn I 190 3mn I Lys Lys Ala Thr 270 Lys Ser Phe Lys Sen 350 Ile hr la In la sp 'ro ;ly 'rc iis .ys Asr Ph Gli 25 Le Le Th Al Ii 33
II
Pt Met His Leu Thr Asn His Leu Leu 160 Phe Ile Glu i Lys Ile 240 Lys 5 u Ser u Ile r Gin a Ile 320 .e Pro .e Thr ie Glu 325 Lys Pro Glu Thr Gin Ile Lys Leu Glu Glu 340 Phe Giu Asn Ile 355 Asn Phe Asn Leu 0* 0 004 S Ser Phe Ser Sen Leu His Tyr 360 Ser Pro Asn 365 Asn Lys Ile Tyr Ala Leu Val Gly 1318 370 375 380 Lys Asn Ala Ser Gly Lys Ser Thr Leu Ile Asn Leu Leu Leu Gly Phe 385 390 395 400 Tyr Thr Pro Asn Ser Gly Gin Ile Ile Ile Asn Asn Lys Tyr Pro Leu 405 410 415 Gin Asp Leu Glu Leu Asn Ser Tyr His Gin Gin Met Ser Ala Ile Phe 420 425 430 Gin Asp Phe Ser Leu Tyr Ala Gly Tyr Ser Ile Asp Asp Asn Leu Phe 435 440 445 Met Gin Asn Asn Ile Thr Lys Giu Gin Leu Lys Gin Lys Arg Giu Ile 450 455 460 Leu Lys Ser Phe Asp Giu Asn Phe Gin Asn Cys Leu Asn Asp Cys Asn 465 470 475 480 Asn Thr Leu Phe Gly Ala Gin Tyr Asn Gly Vai Asp Phe Ser Leu Gly 485 490 495 Gin Lys Gin Arg Ilie Ala Thr Met Arg Ala Phe Leu Lys Pro Ser Asn 500 505 510 Cys Ilie Vai Leu Asp Giu Pro Ser Ser Ala Ile Asp Pro Ile Met Giu 515 520 525 Lys Giu Phe Leu Asp ?he Ile Phe Lys Lys Ser Gin Ser Lys Met Ala 530 535 540 Leu Ile Ile Thr His Arg Met Asn Ser Val Lys Gin Ala Asn Giu Ile .9.545 550 555 560 Ile Val Leu Asp Gin Giy Lys Leu Ile Glu Gin Gly Asn Phe Glu Thr Le Mt565 570 575 LeuMetLysLysGin Gly Leu Phe Cys Glu Leu Phe Leu Lys Gin Gin I..580 585 590 INFORMATION FOR SEQ ID NO:1783: SEQUENCE CHARACTERISTICS: LENGTH: 117 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc_feature LOCATION .117 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1783 Thn Pro Ser Met Ile Val Thr Giu Thn Ser Thr Gly Lys Ile Leu Ala 1 5 10 Leu Val Gly Gly Ile As-p Tyr Lys Lys Ser Ala Phe Asn Arg Ala Thn .9:Gi laLs20 25 GlnAlaLysArg Gin Phe Gly Ser Ala Ile Lys Pro Phe Val Tyn Gin 40 Ile Ala Phe Asp Asn Gly Tyr Ser Thr Thn Sen Lys Ile Pro Asp Thn 55 Ala Arg Asn Phe Giu Asn Gly Asn Tyr Ser Lys Asn Sen Val Gin Asn 70 75 His Ala Tnp His Pro Sen Asn Tyr Thr Ang Lys Phe Leu Gly Leu Val 90 :::Thr Leu Gin Glu Ala Leu Ser His Ser Leu Asn Leu Ala Th Ile Asn 100 105 110 1319 Leu Ala Ile Ala Trp 115 INFORMATION FOR SEQ ID NO:1784: SEQUENCE CHARACTERISTICS: LENGTH: 148 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...148 (xi) SEQUENCE DESCRIPTION: SEQ ID N0:1784 Gin Gly Val Thr Thr Met Ala Phe Gin Val Asn Thr Asn Ile Asn Ala 1 5 10 Met Asn Ala His Val Gln Ser Ala Leu Thr Gin Asn Ala Leu Lys Thr 20 25 S* Ser Leu Glu Arg Leu Ser Ser Gly Leu Arg Ile Asn Lys Ala Ala Asp 40 Asp Ala Ser Gly Met Thr Val Ala Asp Ser Leu Arg Ser Gin Ala Ser 55 i* Ser Leu Gly Gln Ala Ile Pro Asn Thr Asn Asp Gly Met Gly Ile Ile 65 70 75 Gn Val Ala Asp Lys Ala Met Asp Glu Gin Leu Lys Ile Leu Asp Thr 90 Val Lys Val Lys Ala Thr Gin Ala Ala Gin Asp Gly Gin Thr Thr Glu 100 105 110 Ser Arg Lys Ala Ile Gin Ser Asp Ile Val Arg Leu Ile Gin Gly Leu 115 120 125 Asp Asn Ile Gly Asn Thr Thr Thr Tyr Asn Gly Pro Ser Val Ile Val 130 135 140 Trp Ser Ile His Ir. 145 INFORMATION FOR SEQ ID NO:1785: SEQUENCE CHARACTERISTICS: LENGTH: 248 amino acids S* TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...248 (xi) SEQUENCE DESCRIPTION: SE N:1785 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1785 1320 Phe Lys Val Trp Ile Ile Ser Val Thr Gin Arg Leu Ile Thr Gly Gin 1 5 10 Ala Leu Leu Ser Gly Gin Phe Thr Asn Lys Giu Phe Gin Val Gly Ala 25 Tyr Ser Asn Gin Ser Ile Lys Ala Ser Ile Gly Ser Thr Thr Ser Asp 40 Lys Ile Gly Gin Val Arg Ile Ala Thr Gly Ala Leu Ile Thr Ala Ser s0 55 Gly Asp Ile Ser Leu Thr Phe Lys Gin Val Asp Gly Val Asn Asp Val 70 75 Thr Leu Giu Ser Val Lys Val Ser Ser Ser Ala Gly Thr Gly Ile Gly 90 Vai Leu Ala Giu Val Ile Asn Lys Asn Ser Asn Arg Thr Gly Val Lys 100 10S 110 Ala Tyr Ala Ser Vai Ile Thr Thr Ser Asp Val Ala Val Gin Ser Gly 115 120 125 Ser Leu Ser Asn Leu Thr Leu Asn Gly Ile His Leu Gly Asn Ile Ala 130 135 140 Asp Ile Lys Lys Asn Asp Ser Asp Gly Arg Leu Val Thr Ala Ile Asn 145 iSO 155 160 *Ala Val Thr Ser Giu Thr Gly Val Glu Ala Tyr Thr Asp Gin Lys Gly 165 170 175 *Arg Leu Asn Leu Arg Ser Ile Asp Gly Arg Gly Ile Giu Ile Lys Ile 180 185 190 S :Asp Ser Val Ser Msn Giy Pro Ser Ala Leu Thr Lys Arg Trp Ser Lys *195 200 205 Ser Gly Gin Asp Giu Thr Lys Gly Ser Thr Msn Tyr Gly Arg Tyr Ser 210 215 220 Arg Thr Arg Leu Asp Val Arg Ala Ser Met Ser Ile Arg Tyr Leu Asn 225 230 235 240 *9.His Ala Cys Leu Leu Gin Ser TIyr 245 INFORMATION FOR SEQ ID NO:1786: SEQUENCE CHARACTERISTICS: LENGTH: 130 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: 9 ORGANISM: Helicobacter pylori (ix) FEATURE: 9 NAME/ME: misc-feature LOCATION .130 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1786 Ser Pro Leu Trp, Leu Lys Thr Arg Phe Pro Asn Ile Trp Leu Ala Lys 1 5 10 1s Ile Leu Tyr Met Ala Ile Leu Leu Cys Ala Ile Ala His Ser Val Gly 20 25 *Leu Ile Leu Arg Trp Tyr Val Ser Gly His Ser Pro Trp Ser Asn Ala .9935 40 Tyr Glu Ser Met Leu Tyr Ile Ala Trp Ala Ser Val Ile Ala Gly Phe so0 55 ::*Val Leu Arg Ser Lys Leu Ala Leu Ser Ala Ser Ser Phe Leu Ala Gly 70 75 1321 Leu Phe Val Ala His Leu Gly Phe Met Asp Pro Gin Ile Giy 90 Val Pro Val Leu Lys Ser Tyr Trp Leu Asn Ile His Vai Ser 100 105 110 Thr Aia Ser Tyr Gly Phe Leu Giy Leu Cys Phe Val Leu Giy 115 120 125 INFORMATION FOR SEQ ID NO:1787: SEQUENCE CHARACTERISTICS: LENGTH: 370 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Heiicobacter pylori (ix) FEATURE: NAME/KEY: misc -feature LOCATION I1.. .370 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1787 *000 00 0 0*0.
0000 0.
0* *000 00 100. 00.
0* 00*0 *0 00 0 0 0* 0 0* 0* 0 *000 0 00 0 0
LYS
Val Gin Val Pro Leu Ala Giu Asp Leu 145 Asp Giu Phe Ile His 225 Val Asp Leu Gly Sen Asn Giu Ile Asn Asp Ile 130 Asp Ala Giu Leu 210 Ala Ala Giu Glu Lys Ala Val Arg Lys Ile Asp 115 Giu Lys Lys Leu Giu 195 Val Lys Leu Val1 Lys Ser Asn Pro Ile Gly Lys 100 Asn Thr Arg Asn Lys 180 Leu Ala Lys Cys Lys 260 Thr Phe Phe Ang Ser Lys Giu His Leu 135 Arg Clu Lys Glu Gly 215 Asn Leu Leu Leu Thr Ile Giu Ala Leu Glu Phe Gly Leu Leu Gin Asp Lys Ile Leu Lys Ala 155 Leu Sen 170 Pro Leu Phe Leu Asp Leu Lys Val 235 Glu Met 250 Lez Gly Lys Glu Arg Leu Giu Met Gly Leu Sen Val Gly Ile Val Gly Thr Asn Gin Asp Asn Val Asp 125 Asp Lys Lys Thn His 205 Ile Asn Ser Giu Gly Leu Gin Lys Ile Ile Gin Ang 110 Pro Ile Sen Thr Ser 190 Lys Leu Ser Met Glu 270 Leu Ile Arg Leu 1322 Tr Gly 305 Lys Tyr Gly Asn 275 Phe Thr 290 Ser Ser Gly Phe Lys Gly Lys Asp 355 Val 370 Ala Gly Val Lys 295 Ala Pro Val Ala 310 Ile Arg Ala Glu 325 Glu Ala Gly Ala 340 Tyr Ile Val Gin Val Arg Ser Gly Val Ile 315 Ile Ser Tyr 330 Glu Lys Gly 345 Gly Asp Val Ile Lys Lys Asp Phe Glu 320 Phe Ile Ala 335 Arg Ile Glu 350 Phe Arg Phe a. a.
a a..
INFORMATION FOR SEQ ID NO:1788: SEQUENCE CHARACTERISTICS: LENGTH: 141 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .141 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1788 a g*a 9 a. a a a a a a a Arg Lys Ile Gly Lys Sen Glu Ile Pro Leu Phe Ile 50 Phe Met Trp Thr Leu 130 Gin Ile Ala Glu Gin His Ile 115 Met Asn Leu Trp Ile Pro Phe Lys Pro Glu Giu Lys Glu 100 Met Ile Gly Val Gly Gly Gly Gly Val Ala 55 Ala Tyr Met Gin Asn Arg Leu Gly Val Gly 135 Tyr Leu 40 Asn Lys Asp Thr Ile 120 Gly Leu 25 Lys Ser Gin Asn Tyr 105 Leu Phe Ile Pro Phe Met Ile Ala Leu Leu 140 Ala Ile Tyr Glu Sen Phe Ser Glu Val Glu Glu Gly 110 Gly Leu 125 Glu Asn Lys Thr Met Gin Ala Leu Lys Sen Leu Leu Giu Val Ile Thr INFORMATION FOR SEQ ID NO:1789: SEQUENCE CHARACTERISTICS: LENGTH: 77 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES 1323 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .77 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1789 Arg Sen Pro Pro Tyr Sen Phe Leu Phe Thr Thr Pro Giu Val Phe Val 1 5 10 Asn Gin His Phe Pro Trp Leu Sen Gly Ala Gly Arg Leu Val Val Lys 25 Asp Leu Ala Leu Phe Ala Gly Gly Leu Phe Val Ala Gly Phe Asp Ala 40 Lys Ang Tyr Leu Glu Gly Lys Gly Phe Cys Leu Met Asp Ang Ser Ser 55 Val Gly Ile Lys Thn Lys Cys Ser Sen Gly Cys Cys Ser 70 INFORMATION FOR SEQ ID NO:1790: SEQUENCE CHARACTERISTICS: LENGTH: 273 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacten pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .273 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1790 Trp Cys Phe Thr Asn. Ile Gin Glu Ile Giy Asn Asp Phe Leu Ile Pro *1 5 10 is Gin Ser Phe Lys Lys Lys Asp Phe Sen Asn Leu Ala Gin Gin Val Cys 25 His Arg His Glu Gly Phe Gly Ala Asp Gly Leu Val Vai Val Leu Pro 40 Ser Lys Asp Tyr Asp Tyr Giu Trp Asp Phe Tyr Asn Sen Asp Gly Ser 55 *Lys Ala Gly Met Cys Gly Asn Ala Ser Arg Cys Val Gly Leu Phe Ala 70 75 Tyr Gin His Ala Ile Ala-Pro Lys Glu His Val Phe Leu Ala Gly Lys *85 90 Arg Glu Ile Se Ile Arg Ile Glu Glu Pro Asn Ile Val Giu Sen Asn *100 105 110 Leu Gly Asn Tyr Gin Ile Leu Asp Thr Ile Pro Asn Leu Ar; Cys Lys 115 120 125 Lys Phe Phe Thn Asn Asn Sen Val Leu Giu Asn Ile Pro Met Phe Tyr Leu Ile Asn Thn Gly Val Pro His Leu Val Gly Phe Val Lys Asn Lys 145 150S 155 160 Giy Leu Leu Asri Ser Leu Asn Thn Leu Giu Leu Arg Ala Leu Arg His Gu heAs Aa165 170 175 es.heAn l Asn Ile Asn Ile Ala Phe Ile Giu Asn Lys Giu Thr 1324 Ile Cys Asn 225 Giu Tyr Phe Phe Gly 210 Thr Leu Ile 180 Gin Thr Tyr Glu Arg 200 Gly Met Ala Ala Val 215 Lys Lys Ala Thr Leu 230 Leu Lys Asn Asp Gly 245 Met Ser Val Leu Gly 260 185 Gly Phe Ile Ile Met 265 190 Thr Leu Glu Val Asn 270 Leu Ala Phe His Phe Leu 240 Ala Arg 255 Gly Cys a INFORMATION FOR SEQ ID NO:1791: SEQUENCE CHARACTERISTICS: LENGTH: 359 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc feature LOCATION 1 .359 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1791 a a Phe Phe Gin Leu Ser Leu Phe Giu Leu Ser 145 Phe Lyr Ser Ile 225 Leu Trp Asp Phe so Sen Giu Asn Giu 130 Ser Ile Arg Ile Leu 210 Trp Ile Leu Phe Phe Leu Met Gin Val Lys Phe Leu Cys Phe Ile Val 85 Lys Leu Ser 100 Leu Ser His 115 Asn Phe Ser Tyr Ile Gly Leu Gly Leu 165 Tyr Phe Leu 180 Phe Glu Glu 195 Ile Thn Val Phe Gly His Leu Asp Val Val 70 Tyr Ala Phe Ala Lys 150 Leu Gly Val1 Ile Asp 230 Ile Ala Phe 55 Leu
LYS
Leu Pro Ala 135 Tyr Phe Val Ala Leu 215 Gly Leu 40 Leu Val Gly Ile Ala 120 Sen Ser Phe Leu Gly 200 Glu Phe Ile Asn Leu Ser Lys 105 Ile Ile Leu Phe Pro 185 Ile G ly Met Leu Phe Val Ile Lys Gly Tyr 140 Val Tyr Met Ile Phe 220 Val Gin Phe Asn Giy Asp Asn Cys Met Lys Ala Leu Leu Ser Val1 Phe Gly Val 125 Leu Thr Gly Asn Val 205 Gly Tyr Leu Val Val Val Ile Ile Lys Lys Ala
LYS
175 Ser Leu Met Phe Tyr Gly Ile Pro Asn Thr Phe Val1 Leu 160 Phe Lys Thr Ile Leu 240 a.
a a Gly Trp Sen Leu Ile Leu Tyr Gly 1325 Ala Ser Leu Val Pro Ala Val Gly Gly Ala Leu Ile Trp Ile Pro Ile 245 250 255 Ala Ile Tyr Glu Leu Tyr His Gly His Val Asn Glu Ala Ile Phe Ile 260 265 270 Val Leu Tyr Ser Ile Leu Leu Ile Gly Val Leu Ile Asp Ser Val Ile 275 280 285 Lys Pro Ile Leu Ile Val Phe Ile Lys Lys Arg Ile Phe Lys Thr Thr 290 295 300 Leu Lys Ile Asn Glu Ile Leu Ile Phe Phe Ser Met Ile Ala Gly Ile 305 310 315 320 Ser Gin Phe Gly Phe Trp Gly Ile Ile Val Gly Pro Thr Ile Thr Ala 325 330 335 Phe Phe Ile Ala Leu Leu Arg Leu Tyr Glu Asn Tyr Phe Ile Gin Lys 340 345 350 Glu Gin Lys Thr Cys Glu Cys 355 INFORMATION FOR SEQ ID NO:1792: SEQUENCE CHARACTERISTICS: LENGTH: 215 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1 215 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1792 Arg Leu Asn Met Asn Tyr Lys Val Ala Ser Ala Arg Asn Ile Ala Thr 1 5 10 Leu Leu Phe Leu Phe Phe Ser Gin Ser Glu Ala Phe Asp Leu Gly Lys 25 Ile Ala Lys Ile Lys Ala Gly Ala Glu Ser Phe Ser Lys Val Gly Phe 40 Asn Asn Lys Pro Ile Asn Thr Asn Lys Gly Ile Tyr Pro Thr Glu Thr 50 55 Phe Met Thr Ile Met Ala Tyr Met Gin Val Asp Phe Thr Glu Leu Leu 65 70 75 Pro Lys Ser Ala Thr Ala Asn Gly His His Leu Asp Gly Ser Leu Gly S* 85 90 Gly Trp Gly Gly Ala Val Ile Tyr Asp Ser Thr Lys Asp Phe Ile Asn 100 105 110 Glu Val Thr Gly Lys Pro Tyr Gly Ala Met Thr Trp Asn Tyr Val Gly 115 120 125 I'*Tyr Trp Gly Gly Leu Val Gly Gin Lys Pro Trp Ala Ser Cys Gly Leu 130 135 140 Ala Thr Gly Asn Leu Thr Gin Gly Gin Tyr Asp Lys Met Thr Gin Ala 145 150 155 160 Glu Met Thr Gin Leu Ser Asn Gin Glu Ala Leu Ala Ala Ser Thr Cys 165 170 175 Ala Lys Thr Tyr Ala Asp His Thr Arg Asn Tyr Val Ile Tyr Asn Ala 180. 185 190 Tyr Leu Arg Tyr Asn Tyr Lys Asp Ile Phe Glu Ile Arg Gly Gly Arg 195 200 205 Tyr Glu Ser Gin Arg Ile Ile 1.326 INFORMATION FOR SEQ ID NO:1793: SEQUENCE CHARACTERISTICS: LENGTH: 265 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .265 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1793 *5 Ile Phe Tyr Pro Asn 1 Leu Phe Ala Leu Leu Ile Phe Tyr Ala 145 Leu Leu Leu Leu Phe 225 Gly Leu Lys Leu Giu Gly Asn Ser Phe 130 Leu Phe Asn Phe Pro 210 Leu Val Leu Asp Thr Thr Phe Leu Glu 100 Phe Phe Thr Gly Thr 180 Leu Met Gin Phe His 260 5 Ala Leu Thr Leu Phe Ser Ser Asn Phe Leu 165 Arg Val Ser Gin Leu 245 Lys Gly Tyr Leu Gly Thr Val Met Leu 55 Leu Vai 70 Ser Lys Leu Leu Leu Phe Ala Gin 135 Ala Leu 150 Val Leu Ile Lys Gly Val Ser Ser 215 Glu Leu 230 Lys Ile Leu Glu Asn Asn Gin Leu 40 Thr Ala Arg Leu Trp 120 Ser Lys Met
LYS
Val 200 Leu Gin Leu Leu Val 25 Ala Leu le Gly Pro 105 Phe Ser Pro Lys Ala 185 Leu Ser Giu Leu Asp 265 Arg 10 Gly Val Ser Ser Val 90
LYS
Val Val Thr Phe 170 Arg Giu Ile Asn Leu 250 Met Gly Asn Ile Cys Phe Tyr Thr Val Gly 75 Leu Ser Ile Leu Ala Ser Leu Phe 140 Lys Thr 155 Leu Phe Phe Leu Leu Ala Asn Giu 220 LYS Tyr 235 Tyr Gly Phe Val Ser Leu Ala Phe Leu Val 125 Ile Ile Val Leu Phe 205 Gly Tyr Val Leu Lys Ile Gly Sen Gin Phe Phe Ile Lys Ser Leu Pro Met 110 Arg Leu Leu His Gly Val Leu Sen 175 Gly Gly 190 Asn Sen Phe Tyr Leu Leu Ile Arg 255 Vai Asn Ser Ile Asn Pro Val Gly Thr Ala 160 Val1 Leu Leu Tyr Trp 240 Tyr
S.
55 S S
S
.55.
S
S
S
S. S *5 INFORMATION FOR SEQ ID NO:1794: WI SEQUENCE CHARACTERISTICS: LENGTH: 198 amino acids TYPE: amino acid so. CD) TOPOLOGY: linear 1327 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .198 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1794 His Met Lys Gly Leu Tnp Leu Val Ile Ser Leu Val Phe Val Gly Phe 1 S 10 Leu Trp Ala Asn Giu Sen Tyr Val Phe Asn Asn Ser Lys Gly Arg Leu 25 Thn Giu Lys Ser Val Ala Phe Ile Giu Gly Val Ser Lys Giu Leu Tyr 40 Leu Lys Thr Gly Val Arg Phe Ala Ile Asp Met Thr Asp Phe Giu Lys so 55 Asn Pro Ile Ala Leu Ala Asn Lys Lys Glu Arg Gin Sen Tyr Gin Giu 70 75 Giy Phe Leu Lys Gin Leu Lys Pro Pro Phe Val Val Phe Phe Phe Tyr 90 His Asp Ala Gin Lys Ile Giu Leu Val Ala Asn Pro Lys Asp Leu Leu *100 105 110 Asp Thr Asp Lys Ile Phe Phe Giu'Lys Ile Ala Pro Leu Leu Pro Thr 115 120 125 Asn Ala Lys Glu Tyr Thr Pro Gin Arg Ile Ser Ala Met Leu Ile Asn 130 135 140 Gly Tyr Sen Val Ala Val Asp Ala Leu Ala Giu Lys Tyr His Val Asn *145 1SO 155 160 Sle Thr Gin Asn Phe Sen Ala Pro Lys Gly Val Thr Phe Val Lys Val **165 170 175 Val Ile Tyr Ile Leu Leu Leu Thn Leu Leu Gly Ala Phe Leu Gly Leu 180 185 190 Tyr Phe Phe Lys Lys Sen 195 INFORMATION FOR SEQ, ID NO:1795: SEQUENCE CHARACTERISTICS: LENGTH: 197 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori
FEATURE:
NAME/KEY: miscjfeature LOCATION 1 .197 SEQUENCE DESCRIPTION: SEQ ID NO:1795 Giu Gly Lys Sen Met Lys Giu Lys Asn Phe Trp Pro Leu Gly Ile Met 1 5 10 :::Sen Val Leu Ile Phe Gly Leu Giy Ile Val Val Phe Leu Val Val Phe 1328 Asn Ser Pro Ala Asn Phe Ser Asp
LYS
Asp Gin 145 Leu Leu Leu Leu Glu s0
LYS
Pro
LYS
Ser Ser 130 Pro Lys Phe Ala
LYS
Val Ser
LYS
Lys Asn 115 Pro Arg Phe
LYS
Phe 195 Asp Asn Thr Ile 100 Thr Asn Leu Asp Phe 180 Phe Val1 Leu Leu Ser Asn Pro Phe Lys.
Val Giu Phe Thr Pro Giy Leu Lys 125 Pro Ala Arg Ile Lys Tyr Leu Thr Ile 110 Pro Ser Cys Tyr Leu 190 e..
INFORMATION FOR SEQ ID NO:i796: Wi SEQUENCE CHARACTERISTICS: LENGTH: 376 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-featune LOCATION .376 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i796 0* 0* 0* 0* *0 0 0 0 *000 0* *0 0**0 0* *0 1Ala Asn Gin Phe Ala Leu Gin Phe Ser Phe Ser Asp Phe Phe Leu 65 Pro Phe Asn Val1 Gly 145 Phe Asn Phe 50 Trp Sen Val Leu Gly 13 0 Met Asp Phe Phe Lys 70 Lys Ile Leu Asp Met 150 Phe Gin Leu 55 Lys Lys Val1 Gly Tyr 135 Lys Asn Leu Arg Met Ile Met
CYS
Val1 Gin 140 Phe Phe Lou Ala Pro Sen Gly Ala Gly 125 Gin Ile His Gly Gly Tyr Lou Gly Phe Ile Phe Val Ile Val Leu Ser Sen Phe Asn -Ala Sen Lou 160 .0 0 0 000 1329 Ile Val Ser Val Leu Leu Ser Leu Lys Gly Leu Asp Thr Phe Leu Tyr 165 170 175 Ala Pro Phe Leu Lys Asn Pro Leu Phe Glu Met Pro Thr Met Leu Ala 180 185 190 Val Gly Phe Trp Val Leu Val Phe Leu Ser Thr Ser Asn Ala Val Asn 195 200 205 Leu Thr Asp Gly Leu Asp Gly Leu Ala Set Val Pro Ser Ile Phe Thr 210 215 220 Leu Leu Ser Leu Ser Ile Phe Val Tyr Val Ala Gly Asn Ala Glu Phe 225 230 235 240 Ser Lys Tyr Leu Leu Tyr Pro Lys Val lie Asp Val Gly Glu Leu Phe 245 250 255 Val Ile Ser Leu Ala Leu Val Gly Ser Leu Phe Gly Phe Leu Trp Tyr 260 265 270 Asn Cys Asn Pro Ala Ser Val Phe Met Gly Asp Ser Gly Ser Leu Ala 275 280 285 Ile Gly Gly Phe Ile Ala Tyr Asn Ala Ile Val Ser His Asn Glu Ile 290 295 300 Leu Leu Val Leu Met Gly Ser Ile Phe Val Ile Glu Thr Leu Ser Val 305 310 315 320 Ile Leu Gin Val Gly Ser Tyr Lys Thr Arg Lys Lys Arg Leu Phe Leu 325 330 335 Met Ala Pro Ile His His His Phe Glu Gin Lys Gly Trp Ala Glu Asn 340 345 350 Lys Val Ile Val Arg Phe Trp Ile Ile Ser Met Leu Ser Asn Leu Val 355 360 365 Ala Leu Leu Set Leu Lys Val Cys 370 375 INFORMATION FOR SEQ ID NO:1797: SEQUENCE CHARACTERISTICS: LENGTH: 303 amino acids TYPE: amino acid o TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori
FEATURE:
NAME/KEY: mise feature LOCATION 1...303 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1797 Ala Arg Phe Ile Lys Ile Phe Gly Met Gly Lys Phe Ser Lys Leu Gly 1 5 10 Phe Ile Leu Ala Thr Leu Gly Set Ser Ile Gly Leu Gly His Ile Trp 25 Arg Phe Pro Tyr Met Val Gly His Asn Gly Gly Ser Ala Phe Val Leu S L 35 40 Leu Tyr Leu Ala Leu Thr Leu Ser Leu Gly Ile Ala Met Leu Leu Val 55 Glu Met Leu Ile Gly Asn Leu Gly Lys Lys Asp Val Val Ser Asn Tyr 65 70 75 Gin Ile Leu Asp Pro Lys Arg Lys Lys Tyr Tyr Pro Phe Thr Ser Phe *85 90 Phe Ile Leu Gly Gly Pro Leu Ile Leu Ser Phe Tyr Ala Val Val'Leu 100 105 110 Gly Trp Val Leu Tyr Tyr Leu Phe Val Val Thr Phe Asp Leu Pro Lys 1330 115 120 125 Asp Leo Giu Gin Ala Lys Met Gin Phe Ser Met Leu Gin Asn Gly Ser 130 135 140 Le Ile Trp Pro Val Ile Gly Phe Ser Ala Cys Leu Leu Pro Thr Ile 145 150 155 160 Trp Phe Val Ser Arg Gly Ile Glu Glu Gly Ile Giu Lys Leu Asn Val 165 170 175 Val Leo Met Pro Leu Leo Phe Val Ile Phe Ile Gly Leo Leo Ile Tyr 180 185 190 Ala Met Thr Leo Giu Ser Met Pro Lys Ala Leo Arg Phe Leu Phe Asn 195 200 205 The Gu Ile Gin Lys Ile Asp Phe Lys Val Val Met Asp Ala Leo Cly 210 215 220 Gin Met Phe The Ser Leu Ser Leu Gly Val Gly Thr Ile Ile Thr Tyr 225 230 235 240 Ser Ala Phe Thr Pro Lys Lys Glu Asn Leo Leu Lys Ser Ser Leu Phe 245 250 255 Ile Val Leu Pro Gly Ile Le Ile Ser Le Ile Ala Gly Val Met Ile 260 265 270 Phe Thr Phe Val Phe Giu Tyr His Ala Asp Val Ser Gin Gly Pro Gly 275 280 285 Leo Val Phe Ile Ser Leu Pro Leu Thr Phe Ala Lys Met Gly Ser 290 295 300 INFORMATION FOR SEQ ID NO:1798: SEQUENCE CHARACTERISTICS: LENGTH: 426 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori 99 (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. .426 19099.(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1798 *Arg Cys Val Lys Met Lys Ile Ser Leu Leu Gly His Gly Lys Thr Thr 5 10 Leu Ala Leu Gly Arg Phe Phe Lys Lys Asn His Asn Glu Val Lys Phe 25 Phe Asp Asp Lys Phe Pro Ala Phe Phe Lys Asp Sen Glu Gly Phe Leo 40 Cys Tyr Pro Sen Lys Asp Phe Asn Pro Asn Asp Sen Gin Leo Giu Ile so- 55 '.Val Sen Pro Gly Ile Sen Phe Thr His Pro Leu Vai Met Lys Ala Lys 70 75 His Leu Met Sen Giu Tyr Asp Tyr Ile Asp Ser Leo Phe Asp His Ser 90 Phe Thr Pro Thn Met Ile Ser Ile Sen Gly Thr Asn Gly Lys Thr Thr .9100 105 110 *Thr Thr Glu Met Leo Thr Thr Leu Leu Giu Asp Phe Lys Ala Val Ser 115 120 125 Gly Gly Asn Ile Gly Thr Pro Leo Ile Glu Leu Phe Glu Lys Arg .Sen 130 135 140 Pro Leo Trp Val Leo Glu Thr Ser Sen Phe Ser Leo His Tyr Thr Asn 145 150 155 160 1331
LYS
Leu Val.
Phe Phe 225 Ala Leu Tyr His Asp 305 Phe Val1 Leu Giu Gin 385 Pro Glu Ile Asn Pro Ile Glu 230 dly Phe Leu Phe Asn 310 Ile Leu Ser Cys Val 390 Leu Phe Tyr Phe Lys Val 215 Vai Ala Leu Lys Arg 295 Ile His Phe Ser Gin 375 Leu Asp Val Leu Giu Thr 200 Gin Leu Phe Lys Arg 280 Asp Asp Leu Glu Ala 360 Val Leu Gin Leu Leu Asn 185 Ser Asn Giu Leu Ile 265 Leu
LYS
Ala Ile Giu 345 Ser Cys Gin Phe Lys 425 Asn Vai Giu Leu Asn Ala Ile Gin Ala 220 Leu Lys 235 Asp Ala Asn Leu Ala Phe Giy Arg 300 Leu Gin 315 Giy Gly Lys Asn Ile Gin Lys Leu 380 Giu Vai 395 Ser Tyr Ala Leu 205 Gin Ile Ala Lys Lys 285 Leu Ala Asp Tyr Ala 365 Giu Ala Lys Ala Lys 190 Pro Lys Pro Leu Trp 270 Ile Trp Leu Ile Lys 350 Leu Lys Leu Glu op..
4 S
*SO*
op a CLOg 9.e* I 0* g 9* g
S
0I 0 0 0* 9
S.
e.g.
S.
S
S
*SSS
S
p. 5 C S g5 S St B. L
C
P.S.
S S INFORMATION FOR SEQ ID NO:1799: SEQUENCE CHARACTERISTICS: LENGTH: 270 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .270 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i799 Asp Met Gly Asn His Phe Ser Lys Leu Gly Phe Val Leu Ala Ala Leu 1 5 10 Gly Ser Ala Ile Gly Leu Gly His Ile Trp Arg Phe Pro Tyr Met Thr 20 25 Gly Val Ser Gly Gly Gly Ala Phe Val Leu Leu Phe Leu Phe Leu Ser 35 40 Leu Ser Val Giy Ala Ala Met Phe Ile Ala Giu Met Leu Leu Gly Gin 55 Ser Thr Gin Lys Asn Val Thr Glu Ala Phe Lys Giu Leu Asp Ile Asn 1332 70 75 so Pro Lys Lys Arg Trp, Lys Tyr Ala Gly Ile Met Leu Ile Ser Gly Pro 90 Leu Ile Leu Thr Phe Tyr Gly Thr Ile Leu Gly Trp Val Leu Tyr Tyr 100 105 110 Leu Vai Ser Ile Ser Phe Asn Leu Pro Ser Ser Ile Gin Glu Ser Glu 115 120 125 Gin Ile Phe Thr Gin Thr Leu Gin Ser Ile Gly Leu Gin Ser Ile Gly 130 135 140 Leu Phe Ser Val Leu Phe Ile Thr Gly Trp Ile Val Ser Arg Gly Ile 145 150 155 160 Lys Giu Gly Ile Glu Lys Leu Asn Leu Val Leu Met Pro Leu Leu~ Phe 165 170 175 Ala Thr Phe Phe Gly Leu Leu Phe Tyr Ala Met Ser Met Asp Ser Phe 180 185 190 Ser Lys Ala Phe His Phe Met Phe Asp Phe Lys Pro Lys Asp Leu Thr 195 200 205 Ser Gin Val Phe Thr Tyr Ser Leu Gly Gin Vai Phe Phe Ser Leu Ser 210 215 220 Ile Gly Leu Gly Ile Asn Ile Thr Tyr Aia Ala Vai Thr Asp Lys Thr 225 230 235 240 Gin Asn Leu Leu Lys Ser Thr Ile Trp Val Val Leu Ser Gly Ile Leu 245 250 255 Ile Ser Leu Val Gly Arg Ala Tyr Asp Phe His Phe Cys Val 260 265 270 INFORMATION FOR SEQ ID NO:1800: SEQUENCE CHARACTERISTICS: LENGTH: 62 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICA~L: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylorL (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1...62 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1800 Cys Leu Thr Arg His Arg Val Asn Leu His Phe Phe Thr Gly Gly Phe 1 5 10 .Trp Pro Asn Gly Ser Asp Arg Arg Ser Cys Phe Asn Ser Phe Leu Ala 25 Arg Ala Arg Phe Cys Trp, His His Phe Tyr Gly Gly Phe Ile Arg Ala 40 Lys Arg Asp Val Ser Tyr Arg Lys Val Ser Ile Leu Ser Phe 55 INFORM4ATION FOR SEQ ID NO:1801: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 187 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein 1333 (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .187 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1801 Phe Leu Leu Trp Ala Gly Leu Met Ile Phe Thr Phe Val Phe Glu Tyr 1 5 10 Gly Ala Asn Val Ser Gin Giy Thr Gly Leu Ile Phe Thr Ser Leu Pro 25 Val Val Phe Gly Gin Met Gly Ala Ile Gly Val Leu Val Ser Ile Leu 40 Phe Leu Leu Ala Leu Ala Phe Ala Gly Ile Thr Ser Thr Val Ala Leu s0 55 Leu Giu Pro Ser Val Met Tyr Leu Thr Giu Lys Tyr Gin Tyr Ser Arg 70 75 Phe Lys Val Thr Trp Gly Leu Val Ala Leu Ile Phe Val Val Gly Val 90 Vai Leu Ile Phe Ser Leu His Lys Asp Tyr Lys Asp Tyr Leu Thr Phe 100 105 110 Phe Giu Lys Sen Leu Phe Asp Trp Leu Asp Phe Ala Sen Ser Thr Ile 115 120 125 Ile Met Pro Leu Gly Giy Met Ala Thr Phe Ile Phe Met Gly Trp Val *Lu130 135 140 LuLys Lys Glu Lys Leu Arg Leu Leu Ser Ala His Phe Leu Gly Pro 145 150 155 160 Lys Leu Phe Ala Thr Trp Tyr Phe Leu Leu Lys Tyr Ile Thr Pro Leu 165 170 175 Sle Val Phe Ser Ile Tnp Leu Sen Lys Ile Ty r *180 185 INFORMATION FOR SEQ ID NO:1802: (iW SEQUENCE CHARACTERISTICS: LENGTH: 285 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: -mis c..feature LOCATION .285 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1802 Glu Ser Phe Met Gly Cys Ser Phe Ile Phe Lys Lys Val Arg Val Tyr 1 5 10 Sen Lys Met Leu Val Ala Leu Gly Leu Ser Sen Val Leu Ile Gly Cys 25 Ala Met Asn Pro Sen Ala Glu Thr Lys Lys Pro Asn Asp Ala Lys Asn 40 Gin Gin Pro Val Gin Thr His Glu Arg Met Thr Thr Ser Sen Glu His 1334 55 Val Thr Pro Leu Asp Phe Asn Tyr Pro Val His Ile Val Gin Ala Pro 70 75 Gin Asn His His Val Val Gly Ile Leu Met Pro Arg Ile Gin Val Ser 90 Asp Asn Leu Lys Pro Tyr Ile Asp Lys Phe Gin Asp Ala Leu Ile Asn 100 105 110 Gin Ile Gin Thr Ile Phe Glu Lys Arg Gly Tyr Gin Val Leu Arg Phe 115 120 125 Gin Asp Glu Lys Ala Leu Asn Val Gin Asp Lys Lys Lys Ile Phe Ser 130 135 140 Val Leu Asp Leu Lys Gly Trp Val Gly Ile Leu Glu Asp Leu Lys Met 145 150 155 160 Asn Leu Lys Asp Pro Asn Ser Pro Asn Leu Asp Thr Leu Val Asp Gin 165 170 175 Ser Ser Gly Ser Val Trp Phe Asn Phe Tyr Glu Pro Glu Ser Asn Arg 180 185 190 Val Val His Asp Phe Ala Val Glu Val Gly Thr Phe Gin Ala Ile Thr 195 200 205 Tyr Thr Tyr Thr Ser Thr Asn Asn Ala Ser Gly Gly Phe Asn Ser Ser 210 215 220 Lys Ser Val Ile His Glu Asn Leu Asp Lys Asn Arg Glu Asp Ala Ile 225 230 235 240 His Lys Ile Leu Asn Arg Met Tyr Ala Val Val Met Lys Lys Ala Val 245 250 255 Thr Glu Leu Thr Lys Glu Asn Ile Ala Lys Tyr Arg Asp Ala Ile Asp 260 265 270 Arg Met Lys Gly Phe Lys Ser Ser Met Pro Gin Lys Lys 275 280 285 INFORMATION FOR SEQ ID NO:1803: SEQUENCE CHARACTERISTICS: LENGTH: 351 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...351 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1803 Glu Leu Val Leu Phe Glu Lys Leu Lys Phe Phe Lys Ile Lys Lys Asp 1 5 10 Asp Glu Asn Gin Pro Glu Val Asn Leu Asn Ser Glu Ile Tyr Glu Gin 25 Phe Lys Val Phe Arg Leu Pro Leu Ile Leu Ile Gin Leu Leu Val Leu 40 Leu Gly Thr Leu Gly Tyr Phe Ala Leu Glu Asn Tyr Ser Leu Met Gin 55 Ala Phe Phe Gin Thr Thr Tyr Thr Met Thr Ala Thr Gly Phe Gly Ala 70 75 Leu Asn Glu Ser Gin Phe Gly Pro Ile Ser Ile Phe Leu Thr Ser Lle 90 Leu Met Phe Cys Gly Thr Gly Ile Ile Ala Phe Ser Val Ala Ile Leu 100 105 110 1335 Val Ser Val Val Asn Lys Gly Thr Leu Thr Arg Leu Ile Lys Glu Lys 115 120 125 Gly Met Ile Tyr Lys Ile Ala Arg Leu Lys Asp His Tyr Val Ile Cys 130 135 140 Tyr His Asn Glu Tyr Thr Ile Glu Leu Ser Lys Gin Phe Arg Ser Ala 145 150 155 160 Gin Ile Pro Phe Val Val Val Asp Asn Asp Pro Asn Phe Glu Glu Glu 165 170 175 Ala Ile Lys His Lys Tyr Pro Tyr Tyr Ile Ile Gly Asp Pro His Thr 180 185 190 Asn Leu Ala Met Leu Lys Thr His Leu Ser Ser Ala Arg Gly Val Val 195 200 205 Ala Leu Ser Lys Ile Leu Pro Val Asn Val Ala Leu Met Val Ser Val 210 215 220 Arg Leu Phe Glu Lys Glu Leu Lys Arg Lys Pro Tyr Tyr Ile Ile Ala 225 230 235 240 Ser Ala His Ser Asp Glu Gly Leu Glu Lys Leu Lys Lys Leu Gly Ala 245 250 255 Asp Met Val Val Ser Pro Thr Lys Leu Met Ala Gin Arg Val Ser Ala 260 265 270 Met Ala Val Arg Pro Asp Met Glu Asn Ile Leu Glu Arg Phe Ile Asn 275 280 285 Lys Lys Asp Thr Leu Leu Asp Leu Glu Glu Val Ile Val Pro Lys Thr 290 295 300 Ser Trp Leu Val Leu Arg Lys Leu Lys Glu Ala His Phe Arg Glu Ile 305 310 315 320 Ala Lys Ala Phe Val Ile Gly Ile Thr Gin Lys Asp Gly Lys Tyr Ile 325 330 335 Pro Met Pro Asp Gly Lys Arg Leu Leu Gin Ala Asn Pro Ser Tyr 340 345 350 INFORMATION FOR SEQ ID NO:1804: SEQUENCE CHARACTERISTICS: LENGTH: 105 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein •(iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...105 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1804 Thr Lys Lys Leu Asn Asn Thr Leu Phe Asn Lys Gly Leu Ile Ile Phe 1 5 10 Lys Met Phe Lys Lys Ile Ile Phe Leu Cys Val Phe Leu Ile Gly Gly 25 Phe Val Ile Pro Pro Leu Glu Ala Met Pro Ile Leu Arg Asn Lys Thr 40 Pro Lys Lys Asn Tyr Gin Glu Ala His Glu Lys Leu Tyr Arg Set Ile 55 Ile Asn Arg Gin Lys Leu Thr Arg Lys Lys Ser Gly Trp Tyr Phe Leu 70 75 Gly Gly Val Gly Ala Val Glu Ala Ile Lys Asp Tyr Gin Gly Lys Glu 90 Met Lys Asp Trp Met Pro Arg Ser Ile 1336 100 105 INFORMATION FOR SEQ ID NO:180S: SEQUENCE CHARACTERISTICS: LENGTH: 87 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..featune LOCATION .87 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1805 Ile Met Ala Cys Lys Phe Cys Pro Lys Ile Arg Lys Thn Asp Trp Ile 1 5 10 1s Phe Ile Leu Ile Ala Ala Leu Gly Phe Tyr Sen Val Asn Lys Leu Gly 25 Tyr Ala Pro Lys Phe Asn Thr Pro Thr Pro Lys Ser Ser Arg Pro Leu 40 Ser Arg Pro Ile Glu Lys Pro Asn Asn Met Thn Glu Giu Glu Arg Lys so 55 Lys A±-g Phe Ile Giu Leu Gin Lys Ala Cys Leu Leu His Lys Asp Lys 70 75 Lys Ala Cys Giu Glu Val Phe INFORMA.TION FOR SEQ ID NO:1806: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 173 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: CA) NAME/KEY: mis c..feature LOCATION I1.. .173 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i806 Arg Ala Ile Thr Thr Asri Gin Phe Val Gly Thr Asn Met Phe Phe Lys 1 5 10 Thn Tyr Gin Lys Leu Leu dly Ala Sen Cys Leu Ala Leu Tryr Leu Val 25 Gly Cys Gly Asn Gly Gly Gly dly Glu Ser Pro Vai Glu Met le .Ala 40 Asn Sen Giu Gly Thr Phe Gin Ile Asp Sen Lys Ala Asp Sen Ile Thn 55 1337 Ile Gin Gly Val Lys Leu Asn Arg Gly Asn Cys Ala Val Asn Phe Val 70 75 Pro Val Ser Giu Thr Phe Gin Met Gly Val Leu Ser Gin Val Thr Pro 90 Ile Ser Ile Gin Asp Phe Lys Asp Met Ala Ser Thr Tyr Lys Ile Phe 100 105 110 Asp Gin Lys Lys Gly Leu Ala Asn Ile Ala Asn Lys Ile Ser Gin Leu 115 120 125 Giu Gin Lys Gly Val Met Met Giu Pro Gin Thr Leu Asn Phe Gly Giu 130 135 140 Ser Leu Lys Gly Ile Ser Gin Gly Cys Asn Ile Ile Glu Ala Glu Ile 145 iSO 155 160 Gin Thr Asp Lys Gly Aia Trp Thr Phe Asn Phe Asp Lys 165 170 INFORMATION FOR SEQ ID NO:i807: SEQUENCE CHARACTERISTICS: LENGTH: 144 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE; protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni
FEATURE:
NAME/ KEY misc-feature LOCATION .144 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1807 SIle Sen Asn Met Giu Asn Thn Pro Lys Asp Ang Ala Ang Ile Leu Ile 1 5 10 is *Giu Glu Leu Lys Ile Leu Gin Gly Val Ile Asn Ang Met Ala Gin Asn 25 *Sen Leu Giu Cys Lys Lys Trp, Thr Leu Ala Leia Ala Val Gly Vai Leu 40 Sen Leu Lys Ile Giu Ala Ile Ser Asri Phe Tyr Gly Leu Cys Val Leu so 55 *Gly Vai Leu Leu Ala Cys Phe Tyr Leu Leu Asp Ala Tyr Tyr Leu Met 70 75 Gin Glu Ang Leu Phe Ang Giu Gin Tyr Gln.Trp Leu Ile Lys Asn Ang *Leu Lys Thr Asp Giu Arg Leu Phe Glu Val Phe Pro Ile His Gln Thr 100 105 110 Cys Gin Ser Thn Gin Phe Leu Ser Ala Met Ang Sen Phe Ser Leu Phe 115 120 125 Pro Tyr Trp Ala Leu Gly Leu Cys Leu Val Gly Tyr Gly Phe Cys Cys 130 -135 140 INFORMATION FOR SEQ ID NO:1808: SEQUENCE CHARACTERISTICS: LENGTH: 322 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein 1338 iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .322 (xi) SEQUENCE DESCRIPTION: SEQ ID 140:1808 a. a a a. 9* a Pro Lys Leu Ile Ser Leu Asp Asn Leu Phe 145 His Arg Gly Leu Phe 225 Lys Cys Pro Gin Asp 305 Leu Leu Ile Leu Asp Cys Ala Thr Giu Pro 130 Lys Gin Glu Lys Giu 210 Phe Tyr Tyr Phe Gin 290 Ser Lys His Lys Ile Ser Ser Vai Pro 115 Phe Ile Gly Asn Asp 195 Arg
LYS
Lys Giu Lys 275 Met Phe Cys Thr Asn Lys Leu Phe 100 Thr Giu Asp Phe Giy 180 Leu Ile Giu Pro Ala 260 Asn Gin Leu Ile Ser Arg Phe Leu Lys Ala Leu Asn 165 Phe Phe Leu His Trp 245 Giu Asp Ser Phe Val Giu Leu 70 Pro Gly Leu Phe Leu 150 Met Giu Tyr Glu Tyr 230 Arg Ala Phe Phe Arg 310 Lys Pro Asp 55 Gly Asn Asp Leu Cys 135 Arg Gly Lys Pro Leu 215 Pro Ser Ser Phe Lys 295 Ile Giy Val 25 Phe Lys 40 Tyr Ser Giy Leu Tyr Ser Vai Aia 105 Gly Met 120 Asp Phe Phe Ser Phe Leu Ile Ala 185 Giu Gin 200 Pro Ile Lys Ser Val Ser Phe Trp, 265 Lys Giu 280 Thr His Lys Asn 10 Thr Lys Ile Leu Lys 90 Ser Val Cys Gin Val 17 0 Leu Cys His Ile Ser 250 Leu Arg Ile Ile Sen Lys Ala Ser Lys Leu Leu Giy Leu Phe Giu Val Ile Ala Arg Giu Asn 155 Aia Giu Leu Tyr Ile 235 Leu Ala Leu Arg Leu 315 Ala Glu Ala Ser Leu Ile Tyr Asp Arg 140 Giu Asn Phe Ile Asn 220 Met Asn Asn Giu Ser 300 Lys Asn Gin Ser Tyr Cys Ser Phe Thr 125 Thr Leu Leu Leu Asn 205 Clys Leu Gly Leu Met 285 Lys Lys Ile Gin Leu Leu Arg Ile Ala 110 Phe Cys Lys Asp Lys 190 Met Tyr His Ang Phe 270 Ala Thr Val Val1 Asn Giu Asn Leu Asp Leu Ser Lys Arg Leu 175 Thr Val Ser Phe Leu 255 Cys Lys Ile Phe INFORMATION FOR SEQ ID 140:1809: SEQUENCE CHARACTERISTICS: LENGTH: 566 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES 1339 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 566 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i809 Lys 1 Leu Phe Lys Lys Leu Phe Ser Asn Ser Leu I; Phe Sen Val Leu Ile Asp Sen Leu 145 Ile Asn Phe Phe Tyr 225 Val Giy Arg Ile Tyr 305 Ile Gin Ser Glu Lys 385 Asp Phe so ITyr 31u Phe Thr Tyr 130 Ile Ala Ile Ser Asp 210 Leu Leu Tyr Glu Sen 290 Ser Asp Ile Lys Leu 370 Asn Arg Ser 5 Phe Phe Aia S Leu Cys Asn 1 Phe Sen Lys C Tyr Giy Cys I Trp Leu Phe Thr Leu Phe P 100 Leu Leu Ala 115 Lys Asn Tyr I Ala Ile Lys Ser Vai Leu 165 Lys His Leu 180 Leu Ser Leu 195 Arg Gin Gin Pro Sen Asp Val Ile Gly 245 Sen Vai Pro 260 Arg Giu Arg 275 Lys Giu Ala Asp Ala Glu Ile Phe Lys 325 Val Asp Glu 340 Asn Ang Tyr 355 *Val Lys Phe Phe Ile Val Phe Pro Lys 405 Asn Leu His 420 er la ;ly la 00 Ile 4et Ihr Leu Ile 150 ly Ihr Ala Ala Tyr 230 Glu Asn Glu His Thr 310 Arg Trp Tyr Tyr Phe 390 Set Ai Sen Leu Phe 55 Leu Gly Phe Asn Leu 135 Ile Leu Lys Arg Ile 215 Leu Sen Asn Ser Thn 295 Thr Ser Gly Ile Ser 375 His Phe Ser .ys Jal Ser 10 Leu Ile Ser Lys Ser 120 Tyr Arg Ser Asn Gly 200 Lys Sen Ala Pro Asn 280 Ser Lys His Ile Leu 360 Lys Leu Ala Set Gly Gl1 10 Thr Lei 25 Asn Al Gly Al Pro Ly Gly Ii 90 Met Pr 105 Ser G1 Tyr Al Phe Ar Ile Le 17 Asp Al 185 Phe Ty Phe Ty Ser Th Ser At Leu C) 265 Asr L Asp Vz Pro T Tyr G: 3: Thr G.
345 Gly A Asn V, I Leu G Lys P 4 Asp A 425 u La a s e 0 u a 0 '5 Lu 0 an r rr 99 uu 11 rp lu 30 ln sn ly he 10 9g Asp C Tyr I Phe I Lys I 75 Ile I Phe Thr 1 Leu Ala i 155 Thr Ile Ser Ser Gly 235 Asn Glu Phe Phe Tyr 315 Thr Asn Tyr Gin Sen 395 Lys Asp ;lu ,ys jeu krg ?he Ser MAet Ile 140 Leu Ile Leu Ala Phe 220 Asp Phe Arg Val Glu 300 His Phe Leu Gly Prc 380 His Pro Lys Lys Asn Ile Leu Ser Lys 4 Ala 125 Leu Val Gly Lys Tyr 205 Leu Ile Met Thr Phe 285 Sen Tyr Trp Val Ala 365 Gin Sen The Ser Gly Lys Val Gly 110 Phe Ile Pro Ser Arg 190 Leu Asn Ser Gln Arg 270 Ser Leu His Leu Ser 350 Tyr Leu Trp Asp Ile 430 n Lys Lys Thr Met Lys Phe Leu Met Asp Leu Phe Val Tyr Ser Ala Glu Leu Ile Ile Lys Ala Leu Gly Val 160 Val Arg 175 Sen Leu Ser Leu Asn Leu Asn Val 240 Leu Tyr 255 Gin Ala Asp Thr Leu Asn Asn Met 320 Glu Lys 335 Asn Arg Asp Glu Lys Ser I Tyr Ala 400 Leu Ser 415 Val Ala 0 a Ser Gin Asp Tyr Val Asn Ser Leu Tyr Tyr Asn Asp Phe Val Leu Asn Giy Ile 1340 435 440 445 Phe Asn Leu Phe Lys Asp Lys Asp Ala Ile Val Phe Tyr Leu Ser Asp 450 455 460 His Ala Gin Asp Ile Phe Glu Ser Gly Pro Thr Tyr Gly His Ser Cys 465 470 475 480 Ser Lys Ala Gly Leu Glu Ile Pro Phe Met Ile Tyr Val Ser Asp Ile 485 490 495 Phe Lys Glu Lys His Pro Glu Lys Val Lys Leu Ile Lys Asn Ala Leu 500 505 510 Asn Lys Pro Phe Met Ser Asp Asp Leu Ile His Ser Leu Leu Pro Leu 515 520 525 Val Gly Ile His Thr Lys Asp Glu Ile Glu Ser Lys Asn Leu Phe Ser 530 535 540 Pro Gin Phe Asp Ala Gin Arg Lys Arg Ala Val Cys Tyr Gly Ser Met 545 550 555 560 Asn Tyr Asp Arg Thr Lys 565 INFORMATION FOR SEQ ID NO:1810: SEQUENCE CHARACTERISTICS: LENGTH: 74 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori S* (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...74 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1810 Lys Ser Phe Met Pro Pro Thr Arg Pro Gin Ala Ser Ile Leu Arg Leu S* 1 5 10 Thr Leu Lys Asn Pro Leu Ser Met Leu Ser Arg Tyr Ser Leu Cys Leu 25 Leu Lys Lys Thr Arg Leu Gin Thr Thr Ser Asn Ser Ala Pro Lys Ala C 35 40 Cys Leu Ile Ala Gly Leu Leu Lys Lys Ser Lys Pro Phe Ile Leu Asn 55 Thr Leu Lys Ile Arg Ser Leu Leu Lys Pro 65 INFORMATION FOR SEQ ID NO:1811: SEQUENCE CHARACTERISTICS: LENGTH: 85 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori
I
1341 (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...85 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1811 Ser Ala Ser Arg Val Ala Lys Asp Ile Ile Ser Glu Ser Gin 10 Cys Ala Arg Lys Phe Arg Arg Leu Tyr Ala Leu Leu Lys Glu 25 Met Leu Ile Arg Ile Gly Ser Tyr Gin Met Gly Asn Asp Lys 40 Asp Glu Ala Ile Lys Lys Lys Ala Leu Met Glu Gin Phe Leu 55 Asp Glu Asn Ala Leu Gin Pro Phe Glu Gin Ser Phe Gin Gin 75 Glu Ile Leu Arg Asn Asn Glu Val Leu
S
S
S
S
S.
S
INFORMATION FOR SEQ ID NO:1812: SEQUENCE CHARACTERISTICS: LENGTH: 93 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...93 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1812 Asp Lys Arg Asn Ile Met Glu Ser Gin Leu Met Lys 1 5 10 Thr Tyr Lys Ile Thr Leu Met Ile Ser Leu Pro Val 20 25 Leu Val Val Gly Leu Leu Val Ser Ile Phe Gin Ala 35 40 Asn Glu Met Thr Leu Ser Phe Val Pro Lys Ile Leu 55 Val Leu Ile Leu Thr Met Pro Trp Met Thr Asn Met 70 Thr Lys Thr Leu Ile Lys Leu Ile Pro Lys Ile Ile Leu Ala Ile Leu Leu Ala Thr Thr Gin Ala Val Ile Leu Leu Asp Gly INFORMATION FOR SEQ ID NO:1813: SEQUENCE CHARACTERISTICS: LENGTH: 261 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES 1342 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .261 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i813 Lys Ile Ser Pro Cys Lys Leu Gly Asn Ser 145 Gly His Asp Ser Asn 225 Ala Met Leu Glu Thr Thr Ilie Asp Phe Ser Arg Tyr Ser Sen Vai Lys Gly Gin Asp Asp Ile Gly Met Gly 130 Gly Phe Pro Lys 210 Leu Lys Ala Giu Val Lys Phe Gin Lys 115 Glu Phe Arg Lys Ala 195 Lys Gly Thr Pro His Lys Gly Asn Leu 100 Glu Trp Asn Giu Leu 180 Gly Ser Gly Arg Leu Gin Asn Glu Tyr Pro Phe Leu Giy Giy 165 Pro Gin Gly Ala Val 245 Lys Ile Leu Trp 70 Phe Gly Giu Glu Val 150 Val Asn Ala Ala 230C Leu Val Ile Ala 55 Val Arg Thr Ile Lys 135 Val1 Leu Phe Phe Leu 21i5 Phe Gin Ser Gly 40 Leu Giu Ala Leu Lys 120 Giu Leu Lys Gly Arg 200 Pro Giu Giu Val 25 Leu Leu Val Asn Giy 105 Asn Aia Arg Ala Ser 185 Gly Lys Glu Leu Ala Gly Gly Asp 90 Ala Val Leu Ala Cys 170 Cys Arg Gin Ala Giy 250 Giu Asn Lys Gly 75 Leu Leu Leu Gly Arg 155 Lys Phe Giy His Leu 235 Ile Asn Asn Asn Ala Giu Val1 Giu Leu 140 Phe Ser Lys Leu Ala 220 Asp His Asp Leu 45 Ala Gly Lys Ser 125 Asp Lys Met Asn Lys 205 Asn Leu Leu Asn Leu Asp Asn Leu Met 110 Ala Tyr Lys Arg Pro 190 Giy Phe Ile Glu Glu Ile Tyr Ala G iu Asn Cys Arg Thr Lys 175 Pro Leu Leu Giu Giu 255 Ile Ala Ile Sen Phe Ala Val Ser His 160 Ser Asn Leu Val Leu 240 Glu
S
S.
S S
S
S. S
S.
S S
S
S S S. S 5*SS S S *5 S
S.
Vai Lys Ile Leu Arg 260
S.
S S eSS S INFORMATION FOR SEQ ID NO:i814: SEQUENCE CHARACTERISTICS: LENGTH: 90 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION (xi) SEQUENCE DESCRIPTION: SEQ ID NO:18i4 1343 Leu Asn Ser Giu His Pro Leu Phe Asp Trp Ala Ser Lys Gin Thr Tyr 1 5 10 Ile Gin Met Ala Asn Met Met Met Ala Ala Ala Met Leu Gly Ile Asp 25 Ser Cys Pro Ile Giu Gly Tyr Asp Gin Giu Lys Val Ala Ala Tyr Leu 40 Giu Giu Lys Gly Tyr Leu Asn Thr Ala Giu Phe Gly Val Ser Val Met so 55 Ala Ser Phe Giy Tyr Arg Asn Gin Giu Ile Thr Pro Lys Thr Arg Trp 70 75 Lys Thr Giu Val Ile Tyr Giu Val Ile Giu INFORMATION FOR SEQ ID NO:i8iS: (W SEQUENCE CHARACTERISTICS: LENGTH: 377 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Heiicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .377 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:18i5 Lys Giu Ile Thr Met Arg Lys Leu Phe Ile Pro Leu Leu Leu Phe Ser 1 5 10 is *Ala Leu Giu Ala Asn Glu Lys Asn Giy Phe Phe Ile Giu Ala Gly Phe 25 Giu Thr Giy Leu Leu Giu Gly Thr Gin Thr Gin Giu Lys Arg His Thr *35 40 *Thr Thr Lys Asn Thr Tyr Ala Thr Tyr Asn Tyr Leu Pro Thr Asp Thr 55 Ile Leu Lys Arg Ala Ala Asn Leu Phe Thr Asn Ala Giu Ala Ile Ser 70 75 Lys Leu Lys Phe Ser Ser Leu Ser Pro Val Arg Val Leu Tyr Met Tyr 90 000040 Asn Gly Gin Leu Thr Ile Giu Asn Phe Leu Pro Tyr Asn Leu Asn Asn 100 105 110 Val Lys Leu Ser Phe Thr Asp Ala Gin Gly Asn Vai Ile Asp Leu Gly ::115 120 125 Val Ile Giu Thr Ile Pro Lys His Ser Lys Ile Vai Leu Pro Giy Giu 130 135 140 Ala Phe Asp Ser Leu Lys Ile Asp Pro Tyr Thr Leu Phe Leu Pro Lys 145 150 155 160 Ile Giu Ala Thr Sen Thr Ser Ile Sen Asp Ala Asn Thr Gin Arg Val 165 170 175 Phe Giu Thr Leu Asn Lys Ile Lys Thr Asn Leu Val Val Asn Tyr Ang 180 185 190 Asn Giu Asn Lys Phe Lys Asp His Glu Asn His Trp Giu Ala Phe Thr 195 200 205 Pro Gin Thr Ala Giu Giu Phe Thr Asn Leu Met Leu Asn Met Ile Ala 210 215 220 Val Leu Asp Ser Gin Sen Trp Gly Asp Ala Ile Leu Asn Ala Pro P'he 225 230 235 240 Giu Phe Thr Asn Sen Pro Thr Asp Cys Asp Asn Asp Pro Ser Lys Cys 1344 Val Asn Tyr Val Asp Leu 290 Ser Asp 305 Leu Gly Asp Leu Phe Ser Arg Val 370 Pro Leu 275 Asp Ile Val Lys His 355 Pro Gly 260 Asn Val Thr Val Thr 340 Thr Val Asn Gin Val Ser 310 Ser Asn Gly Lys Val 265 Val Asp Asp Ser Lys Lys Phe Gly Val 300 Gly Lys 315 Lys Lys Arg Thr Gly Asn Val Lys 285 Val His Leu Ile Met 365 Asp 270 Asn Gly Tyr Phe Leu 350 Thr 255 Gin Lys Lys Ala Leu Gly Gly Gin 320 Gly Asn 335 His Glu Tyr Gin Leu Asp Pro 330 Glu Asp Leu 345 Glv His Asn V o, 0 0*
V
INFORMATION FOR SEQ ID NO:1816: SEQUENCE CHARACTERISTICS: LENGTH: 216 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...216 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1816 Ile Met Gly Val Gly *5
V
1 Ala Met Thr Asp Ala Val Phe Pro Ile 145 Lys Pro Val Leu Leu 50 Val Lys Phe Ser Leu 130 Ala His Phe Ile Leu 35 Cys Ser Glu Gly Val 115 Leu Gly Ala Asn Thr Asn Val Asp Asp Ser 100 Asn Lys Arg Leu Val 180 5 Gly Gin Ala Ser His Val Phe Asn Val Glu 165 Gin Glu Lys Ala Ser Gly Tyr Leu Asn 55 Asn Ala 70 Cys Asp Glu Asp Phe Ala Lys Pro 135 Ser Met 150 Ala Tyr Val Cys Glu Glu Lys 10 Ser Gly Ile 25 Lys Val Tyr 40 His Ala Leu Leu Lys Glu Val Leu Ile 90 Thr Pro Ile 105 Leu Cys Glu 120 Tyr Ser Lys Leu Phe Leu Ser Asp Ala 170 Leu Ile Glu 185 Glu Asn Asp 200 Gly Leu Ala Leu Cys Glu Val Phe 75 Asn Ser Glu Glu Val Val Ile Phe 140 Gly His 155 Leu Arg Pro Gly Glu Arg Glu Ser Cys Leu Ala Val Gin 125 Asn Tyr Leu Pro Lys 205 Cys Arg Val Asn Gly Lys 110 Leu Leu Ser Glu Val 190 Lys Glu Ser Gin Lys Val Val Leu His Ala Asp Ile Ile Ser Tyr Gly Lys Gin Cys Leu Ser Ser Ala Ser 160 Leu Lys 175 Lys Ser Asn Trp Glu 195 Lys Thr Ala Phe Asp Ser Val 1345 Tyr Ala Leu Glu Val Asn Ala Ala 210 215 INFORMATION FOR SEQ ID NO:1817: SEQUENCE CHARACTERISTICS: LENGTH: 256 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/ KEY misc-feature LOCATION .256 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1817 Asp Ser 1 Met Ile 0 ~0 0* 0 0* 0 Arg Ile Ala 65 Asn Val Leu Ile Asp 145 Ile Leu Ile Val Leu 225 Ile Lys Glu 50 Ser Asp Ile
LYS
Thr 130 Asn Val Val Gly Arg 210 Lys Phe Asn Ang Phe Thin Lys Asn Gin Giu Lys Gin Leu Lys Asp Ala 100 Gin Leu 115 Ile Lys Ile Gin Giy Asp Ile Asp 180 Lys Leu 195 Leu Ser Asn Ala Asn Gly 5 Sen Arg Giu Ser Ang 85 Asp Giu Gin His Ser Ile Gly Gin Giu Ala 245 Ile Leu Tyr Gly Arg Giu 55 Tyr Lys 70 Asp Lys Ile Giu Lys Ile Val Giu 135 Asn Thr 150 Leu Sen Asp Arg Ser Phe Thr Lys 215 Leti. Sen 230 Tyr Aing Lys Ile Phe Pro 40 Val Ile Gin Asn Ile Vai Arg Gly 105 Sen Ala 120 Lys Leu Leu Asp Val Gin Pro Met 185 Giu Ser 200 Leu Ile Gin Ile Leu Gin Ser Ala Phe Ile Cys His Asn Leu 10 Ala Arg Giu Leu Asp 90 Phe Ser Glu Asp Ser 170 Ser Arg Ile Giu Asn 250 Leu Lys Ile Phe Trp Ang Gin Ile 75 Lys Arg Ile Pro Leu Sen Leu Asn 140 Thr Leu 155 Leu Tyr Giu Gin Giu Gin Giu Thin 220 Giu Ile 235 Asp Leu Ala Val Asp Glu Asn Thr Pro Lys 125 Tyr Asp Val Phe Ala 205 Pro Leu Lys Met Val Leu Leu Ser Glu Val Ala Asp Lys Lys Lys Lys Ile Ala Ile Leu Ser Lys Asp Leu 110 Asp Ile Vai Ala Leu Ile Phe Thr Phe 160 Thn Phe Asn 175 Leu Asn His 190 Leu Glu Trp Lys Giu Ala Thr Gly Cys 240 Lys Gly Arg 255 INFORMATION FOR SEQ ID NO:1818: SEQUENCE CHARACTERISTICS: 'LENGTH: 196 amino acids TYPE: amino acid TOPOLOGY: linear 1346 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...196 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1818 Gly Asn Ala Arg Thr Cys Ile Val Ile Cys Trp Asp Cys Leu Asn Gin 1 5 10 Gin Trp Asp Cys Gly Leu Thr Lys Val Asp Pro Lys Ser Thr Ala Val 25 Met Asn Phe Phe Val Gly Gly Leu Ser Ile Val Cys Asn Val Val Val 40 Ile Thr Tyr Ser Ala Leu His Pro Thr Ala Pro Val Glu Gly Ala Glu 55 Asp Ile Val Gin Val Ser His His Leu Thr Ser Phe Tyr Gly Pro Ala 70 75 Thr Gly Leu Leu Phe Gly Phe Thr Tyr Leu Tyr Ala Ala Ile Asn His 90 Thr Phe Gly Leu Asp Trp Arg Pro Tyr Ser Trp Tyr Ser Leu Phe Val 100 105 110 Ala Ile Asn Thr Val Pro Ala Ala Ile Leu Ser His Tyr Ser Asp Met 115 120 125 Leu Asp Asp His Lys Val Leu Gly Ile Thr Glu Gly Asp Trp Trp Ala 130 135 140 Ile Ile Trp Leu Ala Trp Gly Val Leu Trp Leu Thr Ala Phe Ile Glu 145 150 155 160 o. Asn Ile Leu Lys Ile Pro Leu Gly Lys Phe Thr Pro Trp Leu Ala Ile 165 170 175 Ile Glu Gly Ile Leu Thr Ala Trp Ile Pro Ala Trp Leu Leu Phe Ile 180 185 190 Gin His Trp Val 195 INFORMATION FOR SEQ ID NO:1819: SEQUENCE CHARACTERISTICS: LENGTH: 640 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: S* ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...640 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1819 Ser Ile Cys His GIu Tyr Leu Lys Val Asn Leu Gin Glu Lys Leu Ala 1 5 10 Gly Phe Arg Asp Phe Val His Tyr Asn Glu Asn Ala Lys Asp Ser Leu 25 1347 Pro Leu Lys Ala Leu Phe Leu Ser Gly Val Asp Ala Leu Ser Lys Asp 40 Ala Leu Tyr Tyr Leu Giu Lys Ile Met Arg Phe Gly Ser Lys Asn Gly 55 Val Leu Ser Phe Val Asn Leu Giu Ser Giu Lys Asn Asn Gin Ser Ala 70 75 Giu Asp Leu Lys Arg Tyr Ala Glu Phe Phe Lys Asp Arg Thr Ser Phe 90 Glu Gly Leu Lys Tyr Leu Asn Val Giu Ile Ile Ser Asp Gin Gly Ile 100 105 110 Lys Ser Gin His Met Gin Asp Phe Ala Asp Lys Ile Lys Aia Tyr Tyr 115 120 125 Lys Gin Lys Lys Glu Val Lys Arg Giu Leu Lys Asp Leu Gin Arg Asp 130 135 140 Lys Giu Phe Trp Thr Lys Ser Ser Gin His Giu Val Ser Val Pro Val 145 150 155 160 Gly Trp Asp Ile Asn His Lys Giu Val Cys Phe Lys Ile Gly Asn Giu 165 170 175 Gin Asn His Thr Leu Ile Cys Asp His Ser Gly Ser Gly Lys Ser Asi 180 185 190 Phe Leu His Val Leu Ile Gin Asn Leu Ala Phe Tyr Tyr Asp Pro Asp 195 200 205 Giu Val Gin Leu Phe Leu Leu Asp Tyr Lys Glu Gly Val Giu Phe Asn 210 215 220 Ala Tyr Val Ala Asp Pro Ala Leu Glu His Ala Arg Leu Val Ser Val 225 230 235 240 Ala Ser Ser Ile Ser Tyr Gly Ile Thr Phe Leu Lys Trp Leu Cys Asp 245 250 255 Giu Met Gin Lys Arg Ala Asp Arg Phe Lys Gin Phe Asn Val Lys Asp 260 265 270 Leu Ser Asp Tyr Arg Lys His Glu Lys Met Pro Arg Leu Ile Val Val 275 280 285 Ile Asp Giu Phe Gin Val Leu Phe Ser Asp Asn Lys Ser Thr Lys Ala 290 295 300 Val Giu Gly His Leu Asn Thr Leu Leu Lys Lys Gly Arg Ser Tyr Gly 305 310 315 320 *Val His Leu Val Leu Ala Thr Gin Thr Met Arg Gly Thr Asp Ile Asn *325 330 335 Pro Ser Phe Lys Ala Gin Ile Ala Asn Arg Ile Ala Leu Pro Met Asp *340 345 350 *Ala Giu Asp Ser Ser Ser Val Leu Giy Asp Asp Ala Ala Cys Glu Ile 355 360 365 Gin Asn Pro Giu Gly Ile Phe Asn Asn Asn Gly Gly Asn Arg Lys Tyr *Hs370 375 380 HsThr Lys Met Ser Val Pro Lys Ala Pro Asp Asp Phe Lys Ser Phe *385 390 395 400 Leu Thr Lys Ile His Ala Giu Phe Asn Gin Arg Asn Leu Ala Pro Ile 405 410 415 Asp Arg Lys Ile Tyr Asn Gly Giu Thr Pro Leu Lys Met Pro Asp Thr 420 425 430 Lys Ala Asn Giu Met Arg Leu His Leu Gly Lys Lys Val Asp Tyr 435 440 445 Giu Gin Lys Asp Leu Ile Val Giu Phe Giu Ser Asn Giu Ser His Leu *eu450 455 460 LuVal Val Ile Gin Asp-Leu Asn Ala Arg Ile Ala Leu Met Lys Leu 465 470 475 480 Leu Phe Gin Asn Val Lys Ser Ala Asn Lys Giu Leu Vai Phe Cys Asn 485 490 495 Lys Giu Lys Arg Leu Ile Arg Ser Phe Asp Ala Gin Lys Giu Tyr Gly 500 505 510 Ile Thr Pro Val Giu Asn Ile Leu Ser Val Leu Asp Thr Ala Met Asn 515 520 525 Pro Asn Ser Ala Leu Val Ile Asp Asn Leu Asn Giu Ala Lys Glu Leu 530 535 540 His Asp Lys Val Gly Ala Giu Lys Leu Lys Ser Phe Leu Giu Lys Ala 1348 545 550 555 560 Ile Asp Asn Glu Gin Tyr Cys Val Ile Phe Ala His Asp Phe Arg Gin 565 570 575 Ile Lys Thr Asn Tyr His Phe Asp Lys Leu Lys Glu Leu Leu Asn Asn 580 585 590 His Phe Lys Gin Cys Leu Ala Phe Arg Cys Asn Gly Glu Asn Leu Asn 595 600 605 Ala Ile Lys Ser Asp Leu Pro Pro Pro Ser Lys Leu Asn Val Leu Leu 610 615 620 Ile Glu Leu Ser Lys Asp Ser Val Thr Glu Phe Arg Pro Phe Ser Leu 625 630 635 640 INFORMATION FOR SEQ ID NO:1820: SEQUENCE CHARACTERISTICS: LENGTH: 88 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...88 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1820 Arg Pro Asn Leu Ser Ser Gin Phe Leu Tyr Thr Glu Met Leu Ser Leu 1 5 10 Lys Leu Thr Tyr Glu Ser Thr Leu Gin Gin Asp Leu Lys Lys Ile Leu 25 Gly Ile Glu Glu Val Ile Met Leu Ser Thr Ser Pro Met Glu Leu Arg 35 40 Leu Ala Asn Gin Lys Leu Gly Asn Arg Phe rle Lys Thr Leu Gin Ala 55 Met Asn Glu Leu Asp Met Gly Ala Phe Phe Asn Ala Tyr Ala Gin Thr 65 70 75 Thr Gin Arg Ser His Pro Cys His INFORMATION FOR SEQ ID NO:1821: SEQUENCE CHARACTERISTICS: LENGTH: 223 amino acids TYPE: amino acid TOPOLOGY-: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...223 1349 (xiY SEQUENCE DESCRIPTION: SEQ ID NO:1821 Glu Lys Ser Thr Ser Asn Leu Lys Lys Pro Ser Val Trp Arg Ser Lys 1 5 10 Leu Ile CyS Lys Ile Ala Thr His Lys Ala Arg Ser Ile Gly Leu Cys 25 Val Lys Pro Lys Ser Met Lys Giu Lys Leu Arg Gly Ala Met Val Asn 40 Ile Leu Arg Ile Lys Met Ile Giu Ile Ser Giu Trp Leu Gin Lys Leu so 55 Asp Asp Ala Leu Asp Lys Val Vai Ala Lys Lys Giu Pro Giu Ser Phe 70 75 Leu Lys Pro Ile Ile Ser Pro Ile Giu Asp Tyr Gin Lys Ser Val Arg 90 Gin Ile Gin Ala Gin Phe Thr Asp Ala Pro Lys Phe Asn Giu Giu Gly 100 1105 110 Ala Tyr Pro Gin Phe Leu Ser Cys Gly Leu Leu Gin Val Arg Gly Lys 115 120 125 Asn Gly Ala Asn Met Glu Phe Leu Leu Pro Lys Val Tyr Pro Phe Pro 130 135 140 Pro Lys Ser Leu Tyr Ile Glu His Giu Lys Asp Gly Gin Phe Leu Arg 145 150 155 160 Glu Met Leu Met Arg Leu Leu Ser Ser Ala Pro Leu Val Gin Leu Giu 165 170 175 Val Ile Leu Ile Asp Ala Leu Ser Leu Gly Gly Ile Phe Asn Leu Ala 180 185 190 Arg Arg Leu Leu Asp Lys Asn Asn Asp Phe Ile Tyr Gin Gin Arg Ile 195 200 205 Leu Thr Giu Ser Lys Giu Ile Glu Giu Ala Leu Lys His Leu Pro 210 215 220 INFORMATION FOR SEQ ID NO:i822: SEQUENCE CHARACTERISTICS: LENGTH: 113 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .113 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i822 Thr Trp, Val His Phe Leu Thr Leu Thr Leu Lys Gin Pro Lys Asp Pro .1 5 10 is Thr His Ala Thr Ser Tyr Gly Vai Phe Ala Ala Ser Leu Asn Met Giu 25 Leu Lys Lys Ala Leu Arg His Tyr Leu Tyr Ala Gin Thr Ser Asn Met 40 Val Ile Asn Cys Vai Lys Ser Vai Pro Leu Sen Gin Asn Asp Gly Gin 55 Lys Ile Leu Leu Ser Leu Gin Ser Pro Phe Asn Gin Leu Ile Glu Lys 70 75 Thr Leu Glu Leu Asp Giu Ser His Leu Cys Ala Ala Ser Val Gln*Asn 90 Asp Ile Lys Ala Met Gin His Glu Ser Leu Tyr Sen Arg Leu Tyrr Me t 1350 100 105 110 Ser INFORMATION FOR SEQ ID NO:1823: SEQUENCE CHARACTERISTICS: LENGTH: 156 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...156 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1823 Arg Ala Ser Met Lys Asn Phe Ser Pro Leu Tyr Cys Leu Lys Lys Leu 1 5 10 Lys Lys Arg His Leu Ile Ala Leu Ser Leu Pro Leu Leu Ser Tyr Ala 25 Asn Gly Phe Lys Ile Gin Glu Gin Ser Leu Asn Gly Thr Ala Leu Gly 40 Ser Ala Tyr Val Ala Gly Ala Arg Gly Ala Asp Ala Ser Phe Tyr Asn 50 55 Pro Ala Asn Met Gly Phe Thr Asn Asp Trp Gly Glu Asn Arg Ser Glu 65 70 75 Phe Glu Met Thr Thr Thr Val Ile Asn Ile Pro Ala Phe Ser Phe Lys 85 90 Val Pro Thr Thr Asn Gln Gly Leu Tyr Ser Val Thr Ser Leu Glu Ile 100 105 110 S" Asp Lys Ser Gln Gin Asn Ile Leu Gly Ile le. Asn Thr Ile Gly Leu 115 120 125 Gly Asn Ile Leu Lys Ala Leu Gly Asn Thr Ala Ala Thr Asn Gly Leu 130 135 140 Ser Gin Gly Ile Asn Arg Val Gin Gly Val Met Asn *o 145 150 155 INFORMATION FOR SEQ ID NO:1824: SEQUENCE CHARACTERISTICS: LENGTH: 217 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...217 1351 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i824 Ala Asp Arg Giu Asp Lys Leu Ser His Ser Ile Ile Met Arg Tyr Phe 1 5 10 Arg Ser Ala Phe Leu Leu Phe Phe Met Thr Leu Phe Phe Val Ser Cys 25 Ser Lys His Pro Phe Ser Lys Gin Thr Pro Lys Thr Lys Giu Arg Ile 40 Arg Gin Giu Giu Ala Asn Lys Lys Arg Giu Giu Thr Leu Asn Ala Leu so 55 Arg Gin Phe Arg Leu Ile Tyr Ile Asn Thr Pro Val Phe Arg Phe Tyr 70 75 Asp Tyr Gly Thr Ile Lys Thr Asp.Lys Asp His Asn Thr Giu Val Thr 90 Leu Tyr Lys Leu Ser Gin Lys Vai Gly Asp Ile Tyr Met Thr Lys Arg 100 105 110 Ser Ile Cys Phe Ser Gin Lys Cys Ser Ala Lys Trp Ile Aia Aia Arg 115 120 125 Asp Leu Phe Gly Lys Val Ser Tyr Gly Asp Leu Phe Asp Asp Ile Val 130 135 140 Leu Gly Arg Asp Ile Phe Lys Gly Leu Giy Lys Arg His Leu Thr Pro 145 150 155 160 Giu Tyr Val Ile Gin Arg Phe Gin Lys Ser Giy Gu Ile Ile Leu Tyr 165 170 175 Giu Arg Lys Asn Gly Leu Ile Ser Phe Gin Asn Leu Thr Gin Lys Ile 180 185 190 Ala Ile Arg Ile Giu Pro Tyr Giu Pro Ser Leu Gin Asp Leu Glu Asp 195 200 205 Asn Giu Asn Aia Asp Ser Giu Leu Gin 210 215 INFORMATION FOR SEQ ID, NO:1825: ,00*: SEQUENCE CHARACTERISTICS: LENGTH: 236 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein C(iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .236 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1825 **Giu Ile Ala Giu Ile Val Ser Gin Trp Thr His Ile Pro Phe Gin Lys to 01 5 -10 *Met Phe Gin Sen Giu Lys Asn Arg Val Leu Asn Ile Giu Ser Giu Leu 25 Gin Lys Arg Val Val Gly Gin Giu Lys Ala Leu Lys Ala Ile Ala Lys 40 Ala Ile Lys Arg Asn Lys Ala Gly Leu Sen Asp Sen Asn Lys Pro Ile 55 Gly Ser Phe Leu Phe Leu Gly Pro Thr Gly Val Gly Lys Thr Glu Sen 70 75 Ala Lys Ala Leu Ala Gin Phe Leu Phe Asp Sen Asp Lys Asn Leu Ile 90 Arg Ile Asp Met Ser Giu Tyr Met Giu Lys His Ala Ile Sen Arg Leu 1352 100 105 110 Ile Gly Ala Ala Pro Gly Tyr Val Gly Tyr Glu Glu Gly Gly Gin Leu 115 120 125 Thr Glu Ala Val Arg Arg Lys Pro Tyr Ser Val Val Leu Leu Asp Glu 130 135 140 Val Glu Lys Ala His Pro Asp Val Phe Asn Phe Leu Leu Gln Val Phe 145 150 155 160 Asp Glu Gly His Leu Thr Asp Ser Lys Gly Val Arg Val Asp Phe Lys 165 170 175 Asn Thr Ile Leu Ile Leu Thr Ser Asn Val Ala Ser Gly Ala Leu Leu 180 185 190 Glu Glu Asp Leu Ser Glu Ala Asp Lys Gin Lys Ala Ile Lys Glu Ser 195 200 205 Leu Arg Gin Phe Phe Lys Pro Glu Phe Leu Asn Arg Leu Asp Glu Ile 210 215 220 Ile Ser Phe Asn Ala Leu Asp Ser His Ala Ile Ile 225 230 235 INFORMATION FOR SEQ ID NO:1826: SEQUENCE CHARACTERISTICS: LENGTH: 259 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...259 9* 9 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1826 *e Val Arg Phe Cys Tyr Ser Lys Lys Tyr Lys Lys Thr Ile Ile Leu Lys 1 5 10 Lys Asp Trp Met Met Phe Asp Asn Thr Leu Ile Asn Leu Phe Glu Thr **20 25 Ala Pro Leu Leu Thr Ser Leu Leu Ala Gly Ile Leu Thr Phe Leu Ser 35 40 Pro Cys Val Leu Pro Leu Ile Pro Ala Tyr Met Ser Tyr Ile Ser Gin 55 Ile Ser Leu Glu Asp Ile Lys Asp Gly Lys Ala Lys Arg Val Ser Val 65 70 75 Phe Leu Lys Ser Leu Met Phe Val Val Gly Phe Ser Leu Val Phe Leu 90 Gly Val Gly Met Ser Met Ala Lys Leu Ile His Ser Phe Ser Phe Ser 100 105 110 Trp Val Asn Tyr Ile Ala Gly Gly Ile Val Ile Leu Phe Gly Leu His 115 120 125 Phe Leu Gly Val Phe Arg Phe Ala Leu Leu Tyr Lys Thr Gin Ser Ala 130 135 140 Gly Leu Ala Ser Lys Ser Asn Ser Met Gin Arg Phe Tyr Pro Phe Leu 145 150 155 160 Leu Gly Met Ser Phe Ala Leu Gly Trp Thr Pro Cys Ile Gly Pro Ile 165 170 175 Phe Thr Ser Ile Val Ile Met Ser Ala Ser Lys Asp Ala Tyr Gly Leu 180 185 190 Met Leu Met Val Val Phe Val Met Gly Leu Ala Ile Pro Phe Val Leu 195 200 205 1353 Val Ala Leu Met Leu Giu Arg Ala Leu Leu Phe Leu Lys Ser Leu Arc- 210 215 220 Lys Tyr Asn Arg Ala Ile Glu Ile Val Ser Gly Leu Val Leu Ile Leu 225 230 235 240 Met Gly Ile Leu Ile Met Thr Asn Ser Leu Giu Ser Leu Thr Asn Phe 245 250 255 Leu Gin Asn INFORMATION FOR SEQ ID NO:1827: SEQUENCE CHARACTERISTICS: LENGTH: 198 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .198 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1827 Ile
I
Val Phe Met Lys Phe Phe Ile dly Asn 145 Glu Leu Leu Phe Leu Val Asn
LYS
Lys Ala 115 Giu Thr Ala Asri Arg 195 Ser 25 Asn Phe Arg Leu Asp 105 Ala Phe His Leu Thr 185 Gly Gly Ala His Ala Phe Leu Tyr Leu Thr Phe Asp Pro Gin Pro Ile Ala Ser Trp Val Tyr His Giu Gin Asp Thr Ala Lys Asn Leu Asn Thr 125 His Tyr His 140 Lys His Ser 155 Ala Phe Ile Ala Gin Ile Leu Phe Ala Tyr Val Trp Phe Leu Lys Lys Gin Lys Leu Sen 110 Pro Asn Asn Ile Leu Ala His Asn 175 Pro Leu 190 Ile Ala Leu Phe Asp Thn Gin Ser Glu 160 Asp Glu INFORMATION FOR SEQ ID NO:1828: SEQUENCE CHARACTERISTICS: LENGTH: 458 amino acids TYPE: amino acid TOPOLOGY: linear 1354 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .458 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1828 Gin Asp Lys Gly Leu Leu Leu Ser Val Ala Leu Pro Asn Ser Asn Asn 1 5 10 Ala Ser Gin Asn Asn Ile Leu Sen Leu Ser Val Leu His Asn Gin Ile 25 Lys Met Sen Tyr Gly Asn Lys Val Met Asp Phe Thr Pro Pro Thr Leu 40 Gin Asp Tyr Ile Val Gly Ile Gin Gly Gin Ser Ala Leu Asn Gin Ile 55 Giu Ala Val Gly Giy Asn Asn Ala Ile Lys Trp Leu Sen Thr Leu Met 70 75 Met Giu Thr Lys Giu Asn Pro Leu Phe Ala Pro Ile Tyr Leu Giu Asn 90 His Ser Leu Asn Giu Ile Leu Gly Val Thr Lys Asp Leu Gin Asn Thr .99100 105 110 Ala Sen Leu le Ser Asn Pro Asn Phe Arg Asn Aso Ala Thr Ser Leu 115 120 125 Leu Giu Met Aia Ser Tyr Thr Gin Gin Thr Ser Arg Leu Thr Lys Leu 130 135 140 *Sen Asp Phe Arg Ala Arg Giu Giy Giu Ser Asn Phe Ser Giu Arg Leu *145 150 155 160 Leu Giu Leu Lys Asn Lys Arg Phe Sen Asp Pro Asn Pro Sen Glu Val 165 170 175 Phe Val Lys Tyr Ser Gin Leu Sen Lys His Pro Asn Asn Leu Trp Ile 180 185 190 *Gin Gly Val Gly Gly Ala Sen Phe Ile Ser Gly Gly Asn Gly Thr Leu 195 200 205 Tyr Gly Leu As n Val Gly Tyr Asp Arg Leu VaJ. Lys Ser Val Ile Leu :9210 215 220 *Gly Gly Tyr Val Ala Tyr Gly Tyr Ser Gly Phe ,Asn Gly Asn Ile Met 225 230 235 240 His Sen Leu Ala Asn Asn Vai Asp Val Gly Met Tyr Ala Arg Ala Phe 245 250 255 *Leu Lys Arg Asn Giu Phe Thr Leu Sen Ala Asn Giu Thr Tyr Gly Gly 9.*260 265 270 Asn Ala Ser His Ile Asn. Ser Ser Asn Ser Leu Leu Ser Val Leu Asn 275 280 285 Gin Arg Tyr Asn Tyr Asn Thr Trp Thn Thr Ser Val Asn Gly Asn Tyr 290 295 300 Gly Tyr Asp Phe Met Phe Lys Gin Lys Ser Val Val Leu Lys Pro Gin 305 310 315 320 Val Gly Leu Sen Tyr His Phe Ile Gly Leu Sen Gly Met Lys Gly Lys 325 330 335 Met Gin Asn Pro Ala Tyr Gin Gin Phe Val Met His Sen Asn Pro Ser 340 345 350 Asn Giu Sen Val Leu Thr Leu Asn Met Gly Leu Glu Sen Arg Lys Tyr 355 360 365 Phe Gly Lys Asn Sen Tyr Tyr Phe Vai Ti-i Ala Arg Leu Gly Arg Asp 370 375 380 Leu Leu Ile Lys Ala Lys Gly Asp Asn Val Val Ang Phe Val Gly Glu 385 390 395 400 Asri Thr Leu Leu Tyr Arg Lys Gly Giu Ile Phe Asn Thr Phe Ala Ser 405 410 415 1355 Ile Thr Gly Gly Glu Met His Leu Trp Arg Leu Met Tyr Val Asn 420 425 430 Gly Val Gly Leu Lys Met Gly Leu Gin Tyr Gin Asp Leu Asn Ile 435 440 445 Gly Asn Val Gly Met Arg Val Ala Phe 450 455 INFORMATION FOR SEQ ID NO:1829: SEQUENCE CHARACTERISTICS: LENGTH: 251 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...251 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1829 Thr Ile Leu 1 Gly le Gly Ala Gly Val Val Thr Gin 145 Ile Pro Ile Pro Asp 225 Gly Ser Phe Asp Asn Phe Asn Arg 115 Glu Glu Asn Val Val 195 Thr Lys Lys Cys His 20 Thr Phe Asn Lys Gin 100 Thr Ile .Lys Trp Arg 180 Ile Ile Lys Thr 5 Ile Leu Leu Lys Phe 85 Asp Ile Met Leu Leu 165 Leu Tyr Trp Ala Asn 245 Pro Gly Ala Lys Ser Ile Asn Ser Lys 70 Phe Tyr His Leu His 150 Ser Ala Glu Gly Lys 230 Ile Lys Gly Ile Asp Leu Trp Asn Met 135 Asn Leu Ile Gly Tyr 215 Glu Cys Ser Pro 40 Leu Glu Trp Gly Phe 120 Thr Ile Asn Asn Phe 200 Asn Leu Thr Tyr 10 Glu Ala Lys Ala Lys 90 Lys Thr His Val Gin 170 Ala Gin Asn Lys Leu 250 Lys Ala Pro Asp Lys 75 Asp Ala Arg Asn Asp 155 Lys Ile Lys Ile Gln 235 Leu Tyr Leu Phe Tyr Lys Glu Tyr Ala Leu 140 Arg Lys Asn Met Lys 220 Ala Trp Glu Asp Asp Leu Ala Ala Asp Pro Val Lys Ile Leu Asp 110 Leu Ala 125 Asn Glu Ser Pro Tyr Phe Val Asp 190 Val Asn 205 Pro Tyr Gly Tyr Gly Met Tyr Thr Asn Leu Tyr Leu Gly Thr Ile Leu Lys Val Leu Arg Val Glu Gly Leu 160 Asn Asn 175 Asp Tyr Pro Phe Glu Tyr Pro Asn 240 INFORMATION FOR SEQ ID NO:1830: SEQUENCE CHARACTERISTICS: 1356 LENGTH: 879 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY misc-feature LOCATION 1 .879 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i830 Ile His Ile Lys Ang Ile Phe Leu Leu Lys Asn Thr Pro Phe Asn Pro a 1 Pro Asn Asp His 65 Ile Asn Gly Lys Leu 145 Ile Asn Arg Leu Gly 225 Th1r Met Pro Thr Gly 305 Gin Ala Asn :,eu eu ~s kla Ilie Ala Thr Pro Asn 210 Gin Thr Asp Ser Asn 290 Ser Giu Tyr Trp Phe Phe 35 Ile Gin Sen Gin Asp 115 Leu Gin Asn Ser Pro 195 Ala Asp Asn Ala Asp 275 Asp Sen Sen Gly Gly 355 Leu Trp Met Asn Gly Asn 100 Val Gin S en Asp Ile 180 Ile Leu Leu Ile Leu 260 Thr Pro Phe Ala As, 340 Gizn His Asn Arg Ala Leu Leu Ala Giu Ala Leu 165 Gly Asp Ile Phe Lys 245 Giu Leu Lys Lys Thr 325 Thr Ile Ile Ala Thn Phe Val Thr Leu Gin 70 Lys Ile Lys Phe Gin Asn Phe Ser 135 Asn Asp 150 Glu Arg Gly Giu Ser Asn Sen Ser 215 Leu Gly 230 Leu Leu His Sen Ang Giu Giu Phe 295 Glu Lys 310 Lys Val Ser Gin Giu Ile Pro Leu 25 Ser Leu 40 Phe Gly Asn Lys Arg Tyr Gin Tyr 105 Ala Tyr 120 Lys Thr Val His Leu Lys Phe Leu 185 Gly Lys 200 Asp Asn Thr Asp Asn Gin Sen Leu 265 Leu Ile 280 Phe Tyr Phe Ala Ser Asp Asn Lys 345 Lys Asn 360.
Lys Phe Ser Ile Gly 90 Giu Thr Met Ser Giu 170 Phe Tyr Leu Lys Asn 250 Pro Gly Leu Leu Leu 330 Val1 Leu Pro Val Lys Asn 75 Tyr Giu Ser 0 iu Glu 155 His Gly His Val Asp 235 Lys Giu Asp Gin Asp 315 Leu Val1 Thr Phe Lys Tyr Asp Gin Asn Thr Ala 140 Thn Met Gly Gly Pro 220 Lys Leu Giu Asn Gly 300 Lys Asp Asp Pro Met Lys Asn Ala Asn Thr Leu 125 Phe Ser le Ser Asn 205 Tyr His His Val1 Asp 285 Ile Ala Lys Val1 Gly 365 Ile Thr Gin Asn Sen Leu 110 Asn Lys Ang Asn Lys 190 Gly As n Lys Pro Phe 270 Lys Arg Tyr Ile Ser 350 Ser Ile Asn Met Thr Asp Asp Thr Thr Ala Val 175 Val Giu Ile Leu Asp 255 Ile Asn Pro Gin Gly 335 Leu Glu Ile Lys Asn Gin Ile Gin Asp Lys Ala 160 Ala Asp Asp Sen Ile 240 Val Lys Pro Asp Asn 320 His Asn .Asn Leu Asp 370 Phe His Leu Ile Ser Ser Asp Gly Asp Phe Asp Asp Leu Asp Ala Leu Ar; Ser Ser 385 G y Lys 390 Arg Val Thr a a a a a.
a a.
a Phe 'lyr Asn
LYS
Ala 465 Leu Giu Leu Leu Asn 545 Lys Gly Val Gin Val 625 Lys Ala Asp
LYS
Val 705 Leu Asp
LYS
Val Ser 785 His Gly Gin Thr Ala 865 Val Asn Val Val 450 Ile Asp Ar; Ar; Ser 530 Asn Leu Ser Phe Ile 610
LYS
Pro ILeu Asn Gin 690 Ile Phe
LYS
Pro Arg 770 Asp Leu
LYS
Val Tyr 850 Ser Ser Leu Lys Lys Asn 470 Ser Giu Asn Gin 550 Val Ser Leu Asn Tyr 630 Thr Asn
LYS
Asn Asn 710 Ala Lys Phe Leu 790 Ile Asn Arg Ser Ile 870 Leu Giu Asn Ile 455 Leu Thr Vai Ser Lys 535 Gin Aia Giu Asn Asn 615 Asp Thr Glu Leu 695 Met Asn Leu Phe Arg 775 Gly Giu Ile Gly Asn 855 Asn Ser Ile Thr 440 Asn Pro Ile Asp Ser 520 Gly Lys Gin Val Asp 600 Gly Pro Ar; Asp Ser 680 Ser His Asp Asn Asp 760 Pro Ile Lys Ile Giu 840 Leu As n Gin Pro 425 Lys Ala Ile
LYS
Val 505 Lys Leu Thr Thr Ser 585 Vai Ala Thr Gin Pro 665 Lys Ile Ser Phe Ala 745 Gin Asp Gin Met Ar; 825 Thr Thr Leu Vai 410 Ser Leu Ser Asn Asp 490 Giu Giu Giu Ala 570 Lys Asn Phe Thr Leu 650 Ala Glu Asn Asn Ser 730 Asn Leu Ala Asn Ile 810 Ar; Thr Asn Ser 1357 Giu Tyr 395 Lys Ala Val Phe Ser Giu Arg Leu 460 Leu Asp 475 Leu Lys Ile Giu Ser Pro Val Ala 540 Phe Asn 555 Gin Asn Gly Ser Gly Ser Leu Ser 620 Ala Asp 635 Met Asp Ile Tyr Ar; Phe Leu Asn 1700 Thr Lys 715 Gin Asn Asn Ala Giu Asn Leu Gly 780 Gly Ile 795 Ala Lys Asn Glu Gly Thr Asn Tyr 860 Leu Thr 875 Val Lys Val Pro Val Thr 430 Ile Phe 445 Gly Asp Ile Pro Asp Ala Thr Asn 510 Ile Ser 525 Gly Ile Lys Glu Asp Aia Leu Glu 590 Phe Leu 605 Leu Pro Ile Gin Ala Met Gin Gin 670 Ile Glu 685 Giu Giu Met Gin Ala Leu Leu Ile 750 Ile Ile 765 Asp Thr Thr Leu Asn Gly Val Leu 830 Asp Met 845 Asn Ala Lys Tyr Ser Ala 400 Asn Met 415 Lys Asp Gly Asp Glu Ser Ile Leu 480 Ile Lys 495 Gly Ar; Phe Aia Pro Thr Gly Ala 560 Ala Asn 575 Asn Ser Glu Ala Asn Giy Ala Ser 640 Ser Ile 655 Ile Ser Leu Leu Gly Lys Phe Met 720 His Ser 735 Ile Asp Thr Ser Tyr Ser Ile Asp 800 Ala His 815 Lys Thr Ala Giu Val Leu Leu INFORMATION FOR SEQ ID NO:i83i: 1358 SEQUENCE CHARACTERISTICS: LENGTH: 181 amino acids TYPE: amino acid TOPOLOGY: linear {ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...181 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1831 Arg Ile Asp Gin Ile Lys Ile Met Lys Leu Val Ser Leu Ile Val Ala 1 5 10 Leu Val Phe Cys Cys Phe Leu Gly Ala Val Glu Leu Pro Gly Val Tyr 25 Gin Thr Gin Glu Phe Leu Tyr Met Lys Ser Ser Phe Val Glu Phe Phe 40 His Asn Gly Lys Phe Tyr Ala Tyr Gly Ile Ser Asp Val Asp Gly 50 55 Ser Lys Ala Lys Lys Asp Lys Leu Asn Pro Asn Pro Lys Leu Arg Asn 70 75 Arg Ser Asp Lys Gly Val Val Phe Leu Ser Asp Leu Ile Lys Val Gly 85 90 Glu Gin Ser Tyr Lys Gly Gly Lys Ala Tyr Asn Phe Tyr Asp Gly Lys 100 105 110 Thr Tyr His Val Arg Val Thr Gin Asn Ser Asn Gly Asp Leu Glu Phe 115 120 125 Thr Ser Ser Tyr Asp Lys Trp Gly Tyr Val Gly Asn Thr Phe Thr Leu 130 135 140 Lys Arg Val Arg Gly Ala Glu Ile Ser Ile Leu Lys Leu Lys Arg Phe S* 145 150 155 160 Asn Leu Met Arg Ser Phe Tyr Arg Gin Thr His Leu Phe Ser Ile Gly 165 170 175 Lys Ala Tyr Ala Thr 180 INFORMATION FOR SEQ ID NO:1832: SEQUENCE CHARACTERISTICS: LENGTH: 215 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...215 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1832
LYS
Ala Giu Phe Ala Gly Phe Leu Gin Phe 145 Mla Ser Val Asp Ile Arg Met so Tyr Ala Gin
LYS
Val 130 Asn Phe Lys Thr Leu Ser Gly Cys Phe Val Thr Lys 115 Leu Ser Leu Ala 195 Ser Lys Met
S
Leu Cys Ala Met Ala Arg Asp Ile Val Ala Lys Asn 70 Phe Thr Gly Phe Lys Lys 100 Thr Leu Leu Leu Giu Met Val. Gin Lys 150 Trp, Leu Leu 165 Leu Asn Asn 180 Ile Met Giy Phe Val Val Ala Val Gly 25 Asn Tyr Val 40 Leu Met Ser 55 Leu Tyr Leu Phe Tyr Ala Lys Gin Val 105 Phe Thr Leu 120 Val Phe Leu 135 Phe Val Phe Leu Leu Cys Gin Lys Ile 185 Thr Leu Ser 200 1359 Phe Ilie Giu Ala Gin Ser Phe Leu Ile Met Gly Val Ser Leu Phe 75 Phe Leu Ala Gin Thr Pro Giy Val Thr Ile Gly. Ala 140 Leu Ala Giy 155 Thr Met Ser 170 Phe Met Gly Val Thr Leu Gly Leu Cys Phe Leu Leu Lys Leu 125 Ser Thr Leu Val1 Phe 205 Phe Phe Ala Gly Asn Lys Lys 110 Leu Aia Leu Arg Asn 190 Arg Leu Val1 Cys Gly Phe Leu Ser Pro Ser Ala 160 Giy Phe Phe 0
S.
S
S.
0**S 9* 0
S
S S *5 0 0S*S S 0* S
S
*S
S
SO. S Leu Ala 210 Leu Leu Ser Lys Thr 215 INFORMATION FOR SEQ ID NO:1833: SEQUENCE CHARACTERISTICS: LENGTH: 240 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1 .240 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1833 Met Asp Ile Leu Lys Ala Glu His Leu Asn Lys Gin 1 S 10 Lys Ile Val Ser Asp Val Ser Leu Glu Val Lys Ser Gly Leu Leu Gly Pro Asn Gly Ala Gly Lys Thr Thr 40 Ile Cys Gly Leu Leu Glu Pro Ser Gly Gly Ser Val 55 Val Asp Leu Ala Lys Tyr Pro Leu His Lys Arg Ser 70 75 Gly Tyr Leu Pro Gin Glu Ser Ser Ile Phe Lys Giu 90 Glu Asn Leu Ala Leu Ala Gly Glu Ser Thr Phe Lys 100 105 Ser Glu Giu Lys Met Giu Ser Leu Leu Asp Ala Phe Ile Gly Thr Tyr As n Leu Asn Asn Lys Val Tyr Asn Gly Val1 Lys Gin Thr Val Met Asp Ile Giu Glu Ala 1360 115 120 125 Ile Arg Glu Arg Lys Gly Met Ser Leu Ser Gly Gly Glu Arg Arg Arg 130 135 140 Val Glu Ile Ala Arg Ala Leu Met Lys Asn Pro Lys Phe Val Leu Leu 145 150 155 160 Asp Glu Pro Phe Ala Gly Val Asp Pro Ile Ala Val Ile Asp Ile Gin 165 170 175 Arg Ile lie Glu Ser Leu Ile Gly Leu Asn Ile Gly Val Leu Ile Thr 180 185 190 Asp His Asn Val Arg Glu Thr Leu Ser Val Cys His Arg Ala Tyr Val 195 200 205 Ile Lys Ser Gly Thr Leu Leu Ala Ser Gly Asn Ala Asn Glu Ile Tyr 210 215 220 Glu Asn Ala Leu Val Arg Lys Tyr Tyr Leu Gly Glu Asn Phe Lys Val 225 230 235 240 INFORMATION FOR SEQ ID NO:1834: SEQUENCE CHARACTERISTICS: LENGTH: 80 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori
FEATURE:
NAME/KEY: miscfeature LOCATION 1...80 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1834 Asn Thr Gly Leu Trp His Ser Trp Gly Leu Ala Pro Ala Leu Leu Glu 1 5 10 Thr Gin Leu Pro Lys His Ala His Gin Phe Phe Gin Ile Phe Phe Phe 25 Pro Lys Lys Pro Phe Lys Gin Met Ile Val Ile Val Glu Leu Leu Val 35 40 Asn Phe Ile Phe Asn Leu Phe His Ala Ile His Val Gly Val Lys Met 55 Ile Asp Asn Ile Lys Leu Pro Leu Arg Arg Ile Lys Met Arg Ala Leu 65 70 75 INFORMATION FOR SEQ ID NO:1835: SEQUENCE CHARACTERISTICS: LENGTH: 548 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature 1361 LOCATION .548 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1835 0.
S
Ile A 1 Leu P Asp P Ile S 5
LS
Lys T Asn I Gin A Asn 1, Asn 2 2 Pro S 145 Val 2 Arg I Val C Gly T Leu I 225 Ser Val Pro Gly His 305 Val Asn Gin Thr Arg 385 Phe Tyr Gly Ser Ile sp ro ro er 0 !hr xnn let la .30 er sp ys ;ly fal 110 .ys His Pro Ly Phe 290 As Tn Le Asj Se 37, Se: As Al 11 Pr Ph Leu G Gly G 2 Tyr T Asp T Asn L Cys P Phe T a Ile A 115 Pro P Lys C Gin C Lys I Leu 2 195 Glu 2 Thr Thr Val Asp 275 Asn I Cys Gin a Cly p Leu 355 r Ser 0 r Pro n Asp a Lys e Asp 435 o Thr 0 .e Gly ly lu 0 hr hr eu ro hr .00 la 'he .ys ;In :le ~la la Ile Lys Thr 260 Ser Gm Ala Gin Ser 340 Ala Val Ilt Phe Al 42 Le Gl~ G1 V al Ile Giu Thr Ile Pro Lys His Ser 5 Ala Phe Asn Ile Tyr Pro Vai Glu Val 165 Glu Asn Tyr Asn Gly 245 Lys Asp Pro Asp Leu 325 Gin Asn Thr a Leu a Ilf 405 1. Val 1 Let k' Iii y Lei Phe Phe Thr Met 70 Asn Gin Leu Phe Asn 150 Ile Ile Gly Ala Leu 230 Tyr Asp Gly Ala Val 310 Ile *Thi Sei Asz Gi~ 391 SGli As Le a Gl1 a Ar 47 Asp S Phe P 4 Gin A 55 Lys I Asn A Thr P Asp S 2 Thr 2 135 Pro C Leu I Asp I Tyr Leu 215 Glu Gly I Gly I Leu Phe 295 Pro Asn Asn Met i His 375 r Val Leu Gin Asp n Thr 455 g Gly er L 2 ro L 0 rg V 'yr S s5n G la G ier G .20 Lsn S ;iy ~sn I kla N ily 2 200 ksp I spI His Gln Pro 280 Pro Ala Gin Tyr Leu 360 His Asn Ala Lys Phe 440 Lys Leu eu 5 ys 'al er ly lu .05 ;ln ;er Tal .ys Tal L85 ~sn ?ro Leu ksn Val 265 Tyr Sen Gly Asn Asn 345 Ser Phe Ala Tyl Val 42~ Il Arc Ty Lys G Phe G Phe G Asn G 7 Asn 90 Glu I Ser I Ser I Asn C Gin 170 Val I Asp Lys I Arg Gly.
250 Glu Asn' Asn Phe Ala 330 Leu Thr Ser Lys Tyr 410 L Gin 3 Thr Asn c Asn lu lu lu lu r5 7hr 'he 'rp hr fly L55 ;ly eu ;1y Lys Thr 235 Asn Lys Val Tyr Leu 315 Leu Asn Ile Asr Ile 395 G l) Gl Thl Ph Se: Ala P Ala I 4 Thr I Asn I Lys I Thr 2 Gly 2 Asp 140 Arg Ile Lys Glu Leu 220 Ile Met Asp Cys Pro 300 Gly Pro Ala Gin Ala 380 Gly r Ile i Leu Tyr Ser 460 r Tyr 'he 'hr 4 eu 'ro sn ksn ksp :ys Ial Ile Asn Tyr 205 Phe Leu Thr Ser Ser 285 Asn Val Ile Ser Lys 365 Ser Ile Sei Sez 44I Sei
A
3
S
L
Asn Asn Asp Leu 110 Ala Asp Asp Asn Ser 190 Gly Gly His Tyr Asn 270 Leu Ser Thn Asn Leu 350 Thr Gin Gln Lys STyl 430 As: r Se2 r Va Asn Ile Asn Phe Cys Trp Met Leu Ile Leu Ser Asp Thr Lys 160 Asn Phe 175 Gly Val Thr Leu Asn Asp Glu Phe 240 Gin Arg 255 Gly Lys Tyr Gly Ile Tyr Ala Ala 320 Tyr Ala 335 Asn Thr Phe Val Ser Phe Asn Tyr 400 Tyr Asn 415 Gly Gly Lys Asn Phe Gly 1 Leu Asn 480 'ys sp i0 er 465 0 475 Lys Val Lys Gly Ser Giy Asn Leu Asp Val Ala Thr Gly Leu Asn Tyr
I
1362 485 490 495 Arg Tyr Lys His Ser Lys Tyr Ser Val Gly Ile Ser Ile Pro Leu Ile 500 505 510 Gin Arg Lys Ala Ser Val Val Ser Ser Gly Gly Asp Tyr Thr Asn Ser 515 520 525 Phe Val Phe Asn Glu Gly Ala Ser His Phe Lys Val Phe Phe Asn Tyr 530 535 540 Gly Trp Val Phe 545 INFORMATION FOR SEQ ID NO:1836: SEQUENCE CHARACTERISTICS: LENGTH: 420 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...420 SEQUENCE DESCRIPTION: SEQ ID NO:1836 Asp His Ser Phe Asn Ile Gin Asn Ser Ile Lys Arg Lys Val Met Tyr 1 5 10 SAla Ala His Pro Ile Lys Pro Ile Lys Ala Pro Lys Leu Lys Ser Gin 25 Phe Leu Arg Arg Val Phe Val Gly Ala Ser Ile Arg Arg Trp Asn Asp 40 Gin Ala Cys Pro Leu Glu Phe Val Glu Leu Asp Lys Gin Ala His Lys 55 Ala Met Ile Ala Tyr Leu Leu Ala Lys Asp Leu Lys Asp Arg Gly Lys 70 75 Asp Leu Asp Leu Asp Leu Leu Ile Lys Tyr Phe Cys Phe Glu Phe Leu 90 Glu Arg Leu Val Leu Thr Asp Ile Lys Pro Pro Ile Phe Tyr Ala Leu 100 105 110 Gin Gin Thr His Sen Lys Glu Leu Ala Ser Tyr Val Ala Gin Ser Leu 115 120 125 Gin Asp Glu Ile Ser Ala Tyr Phe Ser Leu Giu Glu Leu Lys Glu Tyr 130 135 140 Leu Ser His Arg Pro Gin Ile Leu Glu Thr Gin Ile Leu Glu Ser Ala 145 150 155 160 His Phe Tyr Ala Ser Lys Trp Glu Phe Asp Ile Ile Tyr His Phe Asn 165 170 175 Pro Asn Met Tyr Gly Val Lys Glu Ile Lys Asp Lys Ile Asp Lys Gin 180 185 190 Leu His Asn Asn Asp His Leu Phe Glu Gly Leu Phe Gly Glu Lys Glu 195 200 205 Asp Leu Lys Lys Leu Val Ser Met Phe Gly Gin Leu Arg Phe Gin Lys 210 215 220 Arg Trp Ser Gin Thr Pro Arg Val Pro Gin Thr Ser Val Leu Gly His 225 230 235 240 Thr Leu Cys Val Ala Ile Met Gly Tyr Leu Leu Ser Phe Asp Leu Lys 245 250 255 Ala Cys Lys Ser Met Arg Ile Asn His Phe Leu Gly Gly Leu Phe His 260 265 270 1363 Asp Leu Pro Glu Ile Leu Thr Arg Asp Ile Ile Thr Pro Ile Lys Gln 275 280 285 Ser Val Ala Gly Leu Asp His Cys Ile Lys Glu Ile Glu Lys Lys Glu 290 295 300 Met Gin Asn Lys Val Tyr Ser Phe Val Ser Leu Gly Val Gin Glu Asp 305 310 315 320 Leu Lys Tyr Phe Thr Glu Asn Glu Phe Lys Asn Arg Tyr Lys Asp Lys 325 330 335 Ser His Gin Ile Val Phe Thr Lys Asp Ala Glu Glu Leu Phe Thr Leu 340 345 350 Tyr Asn Ser Asp Glu Tyr Leu Gly Val Cys Gly Glu Leu Leu Lys Val 355 360 365 Cys Asp His Leu Ser Ala Phe Leu Glu Ala Gin Ile Ser Leu Ser His 370 375 380 Gly Ile Ser Ser Tyr Asp Leu Ile Gin Gly Ala Lys Asn Leu Leu Glu 385 390 395 400 Leu Arg Ser Gin Thr Glu Leu Leu Asp Leu Asp Leu Gly Lys Leu Phe 405 410 415 Arg Asp Phe Lys 420 INFORMATION FOR SEQ ID NO:1837: SEQUENCE CHARACTERISTICS: LENGTH: 268 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...268 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1837 Asn Ile Thr Ile Lys Asp Arg Thr Met Lys Thr Asn Gly His Phe Lys 1 5 10 Asp Phe Ala Trp Lys Lys Cys Phe Leu Gly Ala Ser Val Val Ala Leu 25 Leu Val Gly Cys Ser Pro His Ile Ile Glu Thr Asn Glu Val Ala Leu 40 Lys Leu Asn Tyr His Pro Ala Ser Giu Lys Val Gin Ala Leu Asp Glu 55 Lys Ile Leu Leu Leu Arg Pro Ala Phe Gin Tyr Ser Asp Asn Ile Ala 70 75 Lys Glu Tyr Glu Asn Lys Phe Lys Asn Gin Thr Thr Leu Lys Val Glu 90 Glu Ile Leu Gin Asn Gin Gly Tyr Lys Val Ile Asn Val Asp Ser Ser 100 105 110 Asp Lys Asp Asp Phe Ser Phe Ala Gin Lys Lys Glu Gly Tyr Leu Ala 115 120 125 Val Ala Met Asn Gly Glu Ile Val Leu Arg Pro Asp Pro Lys Arg Thr 130 135 140 Ile Gin Lys Lys Ser Glu Pro Gly Leu Leu Phe Ser Thr Gly Leu Asp 145 150 155 160 Lys Met Glu Arg Val Leu Ile Pro Ala Gly Phe Val Lys Val Thr Ile 165 170 175 Leu Lys Pro Met Ser Gly Glu Ser Leu Asp Ser Phe Thr Met Asp Leu 1364 180 185 190 Ser Glu Leu Asp Ile Gin Glu Lys Phe Leu Lys Thr Thr His Ser Ser 195 200 205 His Ser Gly Gly Leu Val Ser Thr Met Val Lys Gly Thr Asp Asn Ser 210 215 220 Asn Asp Ala Ile Lys Ser Ala Leu Asn Lys Ile Phe Ala Ser Ile Met 225 230 235 240 Gin Glu Met Asp Lys Lys Leu Thr Gin Arg Asn Leu Glu Ser Tyr Gin 245 250 255 Lys Asp Ala Lys Glu Leu Lys Asn Lys Arg Asn Arg 260 265 INFORMATION FOR SEQ ID NO:1838: SEQUENCE CHARACTERISTICS: LENGTH: 100 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...100 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1838 Ser Asn Phe Lys Lys Gly Phe Phe Met Phe Lys Ser Arg Leu Asn Ser 1 5 10 Trp Ile Leu Leu Gly Ile Leu Gly Val Leu Val Val Val Phe Trp Asp 25 Val Ile Lys Tyr Lys Ile Glu Asp Leu Gin His Asp His Tyr Leu Ser 35 40 Gln Val Lys Glu Arg Glu Glu Tyr Tyr Lys Asn His Ile Glu Glu Ala 50 55 Leu Lys Lys Asp Ser Glu Cys Phe Glu Lys Gly Gly Asp Lys Val Asp 70 75 Cys Ser Ala Ala Met Arg Ile Ala Ala Gly Glu Arg Asn Arg Arg Met 85 90 Leu Glu Ile Lys 100 INFORMATION FOR SEQ ID NO:1839: SEQUENCE CHARACTERISTICS: LENGTH: 242 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc feature 1365 LOCATION .242 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i839 Lys Gin Asp Lys Leu Trp Giu Leu Ile Lys 145 Ser Ala Arg Ile Asp 225 Ser Leu Phe Leu Val Ile Ilie Phe Gin Asp Arg Leu Arg Val Lys Gly Leu 130 Asn Lys Tyr Ile Pro 210 Asp Leu Leu Leu Ile Asn Phe Lys Ala 115 Asp Ala Val His Thr 195 Met Leu Gin Asp Ala Ala Asn Lys 100 Val Leu Leu His Trp 180 Thr Asn Ile His Thr Phe Leu G iu Giu Ile Lys Phe Ile 165 Glu Tyr Ile Lys Phe Ile Asp 70 Ser Ile Arg Arg Ile 150 Ala Asn Phe Ser Ser 230 Lys Asp Thr 55 Tyr Val Thr Leu Ile 135 Asn Leu Leu Ile Val 215 Ile Asn Ser 40 Pro Cys Leu His Ile 120 Asn Asn Asn Leu G ly 200 G iu Gly Asp 25 Leu Lys Leu Thr Ser 105 Phe Phe Lys Leu Lys 185 Leu Pro Asn Lys 10 Ile G iu Ile Thr Pro 90 Leu Cys Lys Lys Leu 170 Ile Lys Ser Lys Thr Lou Arg Giu Thr Gin Ser Gin 75 Lou Ile Tyr Ser Asn Trp Gin Asp Lys Asp 235 Leu Tyr Asn Met Ile Leu Lys Tyr 140 Pro Thr Pro Asn Ile 220 Leu Ile Lys Leu Lys Lys Ser Leu 125 Tyr Lou Ile Asn Asp 205 Val Glu Lou Giu Giu Giy Giu Lys 110 Giu Pro Ser Arg Lys 190 Arg Leu Asp Ile Ser Asn Ile Sor Leu Met Gly Asn Ser Asn 175 Arg Ala Phe Leu Met Lys Leu Glu Lys Ser Val Asn Ala 160 Arg Pro Arg Lou Ser 240 a
S
*5*a a. a a a.
a INFORMATION FOR SEQ ID NO:1840: SEQUENCE CHARACTERISTICS: LENGTH: 467 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .467 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1840 Gly Met Lys Ala Leu Lys Thr Phe Lou Lys Lys Ser Lou Ile Leu Leu 1 5 10 Leu Ala Ile Ala Leu Asn His Lou Asn Ala Vai Ala Met Ile Val Asp 25 Asn Pro Thr Gin Asn Ala Trp Asn Gly Ala Lys Arg Ala Trp Asp Glu 40 Ser Lys Trp Ala Lys His Lou Ala Thr Ile Thr Giu Arg Ile Lys Lou 1366 Ala Gin Asp Thr Leu Asp Arg Ala Asn Gin Lys Val Asn Asp 5
S
S. S.
S
S. S
S
*5 Ile Phe Gin Lys 145 Glu Asn Ile Leu Ile 225 Tyr Gin Ser Thr Giu 305 Asn Asp Ala Met 385 Ile Gi1; Ala Sei Asr 465 Leu Ser Ala Lys 115 Asn Tyr2 130 Cys Pro Lys Asn Thr Lys Ser Thr 195 Giu Tyr 210 Gin Leu Thr Ala Ile Ala Gin Asp 275 Phe Giy 290 Asn Arg Arg Leu Ile Ala Lys His 355 Gin Asn 370 Gin Ser Pro Ala Gin Lys Tyr Gly 435 Asn Ser 450 i Pro Tyr Ele 100 'In ksp 31u Laeu Ala Ala Ile Leu Tyr Ser 260 Arg Phe Asn Lys Giy 340 Arg Leu Tyr Asp Gin 420 Phe Asn lal as ?ro lal I le Laeu H~is 165 Laeu Asn Cys Asp Glu 245 Asn Ala Asn Gly Ala 325 Lys Phe Ser Ala Aia 401 Gir Leu AsnI Asn Pro Gin Ala2 Arg Asn 135 Asn Trp 150 Gin Phe Lys Asp Asp Leu Ile Gin 215 Ser Gin 230 Lys Leu Val Tyr Phe Ser Asp Glu 295 Lys Ser 310 Gin Phe Lys Gly *Gin Gin *Phe Met 375 Phe Lys 390 Leu Lys Gio Ile .ys de t 1 sn L2 0 ksp Phe Phe Gly 200 Lys Met Arg Ala Gin 280 Asn Glu Asp Giu Leu 360 Asn Gin Asp Giu Ser 440C Pro Thr Gin 105 Thr Ile Vai Thr Aia 185 Ala Gly Thr Ala Lys 265 Met Val Cys Glu Ala 345 Ser Lys *Gin Asp Lys 425 *Val Ser ksn 90 Tyr Glu Ala Ser Ser 170 Asn Gly Asn Lau Giu 250 Val Asp Lys Ile Lau 330 Ala Val Thr Met Lys 410 Val Gly Ser rhr 75 31n Jal Arg Ala Gln 155 Lys Ala Leu Leu Aia 235 Lys Lys Asn Lys Pro 315 Asi Ala Git Leu Glj 395 Ly As~ Leu2 Phe Glu Ile Lys 140 Asp Gly Ile Arg Gbu 220 Leu Glu Gin Glu Gly 300 Asn Lau Lys Thr Giy 380 rTyr 1His Arg Ala SAsn 460 ksn eu -lys Lys 12 krg Ala L~ys Giy Gly 205 Ala Leu Giu Leu Leu 285 Tyr Met Asp Val Ala 365 Leu Phe Gin Ala Ser 445 Ile Ser Thr Ile 110 Gbu Ile Ser Gbu Asn 190 Arg Aia Asn Leu Val 270 Gly Cys Leu Tyr Phe 350 Leu Met Giu *Gbu *Lys 430 Gly *Gin I le ;iy 31n ksn Ser Pro Ser 175 Thr Ala Lys Asn Lys 255 Vai Val
LYS
Asn Ser 335 Asn Gbu Val Asp Asn 415 Leu Val Ser Asn Ser Ser Ala Giu Thr 160 Ala Gin Leo Lys Asp 240 Arg Ala Lys Lys Val 320 Arg Asp Ile Gin Ile 400 Leu Asp Asn Phe Pro Asn Gly Asn Glu Ala 455 INFORMATION FOR SEQ ID NO:184b: SEQUENCE CHARACTERISTICS: LENGTH: 424 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES 1367 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATUJRE: NAME/KEY: misc_feature LOCATION .424 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:184i Arg Leu Asn Asn Met Ala Ala Pro Leu Leu Ala Leu Pro Phe Leu Ser 1 5 10 Asn Pro Leu Val Leu Gly Ala Leu Ala Val Ile Gly Val Gly Ala Tyr 25 Leu Tyr Pro Asn Lys Gin Asp Ser Leu Val Val Gin Ala Asp Gly Leu 40 Tyr Ser Giu Ile Leu Gly Phe Phe Ile Ser Phe Ser Ser Lys Ile Leu 55 Lys Gly Ile Gly Glu Pro Leu Ala Asn Val Ile Gin Pro Phe Gly Met 70 75 Val Leu Gly Met Leu Leu Ile Leu Leu Tyr Ser Phe Lys Arg Tyr Gin 90 *Asn Asn Asp Leu Phe Giu Ile Lys Thr Phe Leu Met Leu Phe Vai Phe 100 la 105 110 Vai Gly Tyr Leu Ser Leu Tyr His Tyr Ala Phe Lys Ser Asp Gly Ser *115 120 125 Ser Ser Giy Asn Gly Arg Ser Ser Phe Ala Phe Gin Asn His Val Thr *.*130 135 140 Giu Ile Phe Asp Thr Pro Ala Asn Leu Leu Asn Ala Gly Ile Ser Asn *145 150 155 160 Val Val Lys Giu Tyr Gin Thr Asn Ser Ala Arg Giu His Lys Asn Ile 165 170 175 *Asp Thr His His Ser Ile Thr Asn Ala Asn Ile Ser Phe His Val Arg inli Lu180 185 190 GlnIleLeuThr Ser Leu Asn Lys Leu Tyr Glu Asp Phe Ly's Ile Asn 195 200 205 Asn Gly Leu Ser Leu Lys Thr Leu Ile Ala Ala Val Leu Leu Leu Val 210 215 220 Ile Leu Gly Leu Glu Leu Phe Leu Leu Phe L 's Val Phe Cys Tyr Val 225 230 235 240 Phe Met Thr Tyr Leu Glu Lys Ile Ile Ty'r Leu Ser Leu Val Ile Phe 245 250 255 :::Met Leu Leu Leu Gly Phe Phe Gin Gin Thr Arg Gly Phe Leu Val Ser 260 265 270 Tyr Val Lys Lys Ile Ile Ser Leu Thr Phe Tyr Met Pro Leu Leu Leu 275 280 285 Leu Leu Vai Leu Phe Asn Ser Phe Ala Leu Gin Tyr Ala Ile Lys Val 290 295 300 Gly Gly Ser Asn Giu Ile Val Ala Lys Phe Gly Ile Ile Val Ala Ile 305 310 315 320 Gly Ile Ser Leu Thr Phe Ile Gin Lys Val Pro Giu Met Ile Asn Ala 325 -330 335 Ile Phe Gly Thr Gin Gly Gly Leu Thr Asp Ala Lys Ser Phe Ile Tyr 340 345 350 Gin Gly Val Gin Met Ala Ser Ala Gly Ala Gly Ala Ile Ala Gly Ser 355 360 365 Leu Lys Ser Val Gly Arg Ser Ala Phe Gly Arg Thr Leu Glu Ala Tyr 370 375 380 Lys Asp Ala Lys Ser Thr Ile Asn Ser Thr Thr Ala Asn Met Arg Asp 385 390 395 400 Met Pro Gly His Pro Gly Val Arg Val Gly Val Glu Thr Ile Giu Leu 405 410 415 Pro Lys Ser His Arg Ala Ser Lys 420 1368 INFORMATION FOR SEQ ID NO:i842: SEQUENCE CHARACTERISTICS: LENGTH: 384 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc_feature LOCATION .384 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1842 Lys Arg Leu His Thr.
Ile Lys
LYS
Leu Leu 145 met Giu Leu Gly Leu 225 Pro Asp Met Thr Gly 305 Lys Leu k.sn Arg Tyr Leu Lys Arg Gly Arg Asn Ala Ile Leu Giu Pro Sen k.sn Phe ksn s0 Ile Sen Clu Thr Ser 130 Phe Gly Pro Asn Gly 210 Leu Asn Cys Leu Asn 290 Ile Glu Lys Arg Leu 35 Gin.
Pro Leu Gly Asn 115 His Leu Gly Ile Leu 195 Phe Leu Thr Ala Giu 275 Leu Leu Leu Val Leu 20 Ile Ala Lys Pro Ala 100 Arg His His Trp His 180 Ser Met
LYS
Leu Val 260 Thr Lys Tyr Trp Leu 340 5 Lays Ile Leu Pro Asn 85 Arg Trp Sen Asp Ala 165 Phe His Leu Phe Asn 245 Met Cys Asn Leu Leu 325 His Met Val1 Asn 70 Asp Asp Ser His Asn 150 Thr Lys Leu Pro Asp 230 His Ala Lys Leu Ile 310 Sen Ala Lys Thr 55 Asp Asn Val Giu Giu 135 Lys Sen Phe Val Leu 215 Gin Gin Phe Thr Asp 295 His Lys Ala His 40 Gin Ala Leu
LYS
Ala 120 Tyr Ile Lys Ala Arg 200 Gin Leu Arg Pro 280 Asp Asn Leu Phe 25 Gin Thr Leu Leu Ile 105 Phe Ile Leu Ile Arg 185 Asn His Asn Gin Asn 265 Thr Sen Pro Giu 10 Phe Thr Pro Sen Ser 90 Ser Ile Lys Leu Tyr 170 Lys Lys Glu Asn Pro 250 His Asp Leu Sen Asn 330 Val Ser Pro Ala 75 Ala Ala Leu Lys Phe 155 Gin Leu Pro Leu Pro 235 Ser Sen Trp Asn Asp 315 Ser Gly Pro Tyr His Tyr Asn Leu Leu 140 Val Phe Ser Leu Ala 220 Ang Leu Phe Gin Leu 300 Leu Asn Leu Tyr~ Phe Ala Phe Leu Thr 125 Gly Val Giu Leu Asn 205 Thr Glu Thr Lys Lys 285 Leu Ser Ser Phe Alia Thn Ser Sen Phe 110 Lys Asn Gly Ser Sen 190 Thr Gin Leu Pro Asp 270 Pro Asn Leu Phe Ile Phe Gin Sen Gly Asp Giu Pro Val Ala 175 Pro Thr Tyr Leu Phe 255 Sen Ile Leu Arg Lys 335 Val Thr Leu Leu Thr Ser Giu Leu Ser 160 Leu Phe Asp Pro Arg 240 Lys Leu Sen Asn Ang 320 Thr Asp Lys Ala Asn Giu Val Sen Tyr Pro Sen Tyr Ser 1369 Leu Asn Pro His Phe Ile Asp Ile Val Tyr Thr Tyr Asn Arg Ser His 355 360 365 Ile Lys His Ile Arg Phe Asn Met Ala Tyr Leu Asn Ser Leu Leu Lys 370 375 380 INFORMATION FOR SEQ ID NO:1843: SEQUENCE CHARACTERISTICS: LENGTH: 185 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...185 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1843 Leu Val Met Phe Ile Ser Ser Ser Tyr Thr Leu Ser Phe Val Trp Leu 1 5 10 Phe Leu Ile Phe Phe Phe Phe Lys Asn Lys Pro Leu Gly Leu Arg Phe 25 Ser Leu Ser Leu Ile Ser Val Ile Leu Ser Asn Ile Ala Leu Lys Asp 40 SSer Leu Ser Leu Asn Glu Phe Leu Ser Ser Phe Thr Ala Pro Leu Ser 50 55 SPro Phe Ser Cys Leu Leu Ile Leu Ala Tyr Ala Ser Phe Ser Cys His 70 75 Ile Leu Lys Lys Pro Pro Leu Glu Thr Leu Gin Ser Tyr Ser Val Met 85 90 Leu Phe Phe Asn Leu Leu Leu Leu Thr Asp lie Leu Gly Phe Leu Pro 100 105 110 Phe Ser Ile Tyr His His Phe Met Ala Ser Leu Ile Phe Ser Ala Leu 115 120 125 Phe Cys Ser Ser Leu Phe Leu Ser Ser Pro Leu Leu Gly Val Ile Ala 130 135 140 Leu Val Ala Leu Ser Ser Ser Leu Leu Met Arg Ser Asn Phe Gin Ile 145 150 155 160 Leu Asp Ser Leu Leu Asp Phe Pro Leu Phe Leu Phe Val Phe Phe Lys 165 170 175 Thr Leu Tyr Leu Ala Lys Lys Arg Leu 180 185 INFORMATION FOR SEQ ID NO:1844: SEQUENCE CHARACTERISTICS: LENGTH: 982 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori 1370 (ix) FEATURE: NAME/KEY: misc-feature LOCATION .982 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i844 Lys Arg Ile Leu Met Lys Lys Arg Lys His Val Ser Lys Lys Val Phe 1 5 10 Asn Val Ile Ile Leu Phe Val Ala Val Phe Thr Leu Leu Val Val Ile 25 His Lys Thr Leu Ser Asn Gly Ile His Ile Gin Asn Leu Lys Ile Gly 40' Lys Leu Gly Ile Ser Giu Leu Tyr Leu Lys Leu Asn Asn Lys Leu Ser s0 55 Leu Giu Val Giu Arg Val Asp Leu Ser Ser Phe Phe His Gin Lys Pro 70 75 Thr Lys Lys Arg Leu Glu Val Ser Asp Leu Ile Lys Asn Ile Arg Tyr 90 Gly Ile Trp Ala Vai Ser Tyr Phe Giu Lys Leu Lys Val Lys Glu Ile 100 105 110 Ile Leu Asp Asp Lys Asn Lys Ala Asn Ile Phe Phe Asp Gly Asn Lys 115 120 125 owe* Tyr Giu Leu Giu Phe Pro Gly Ile Lys Gly Giu Phe Ser Leu Giu Asp 130 135 140 Asp Lys Asn Ile Lys Leu Lys Ile Ile Asn Leu Leu Phe Lys Asp Val 145 150 155 160 Lys Val Gin Val Asp Giy Asn Ala His Tyr Ser Pro Lys Ala Arg Lys Me l PeAn165 170 175 MetAlaPheAsnLeu Ile Val Lys Pro Leu Val Giu Pro Ser Ala Ala 180 185 190 Ile Tyr Leu Gin Gly Leu Thr Asp Leu Lys Thr Ile Giu Leu Lys Ile STr195 200 205 Asn TrSer Pro Met Lys Ser Leu Ala Phe Leu Lys Pro Leu Phe Gin 9..*210 215 220 Arg Gin Ser Gin Lys Asn Leu Lys Thr Trp Ile Phe Asp Lys Ile Gin 225 230 235 240 Phe Ala Ser Phe Lys Ile Asp Asn Ala Leu Ile Lys Ala Asn Phe Thr 245 250 .255 Pro Ser Giu Phe Ile Pro Ser Leu Leu Giu Asn Ser Val Val Lys Ala 260 265 270 Thr Leu Ile Lys Pro Ser Val Val Phe Asn Asp Gly Leu Ser Pro Ile :275 280 285 see a Lys Met Asp Lys Thr Giu Leu Ile Phe Lys Asn Lys Gin Leu Leu Ile 290 295 300 Gin Pro Gin Lys Ile Thr Tyr Glu Thr Met Giu Leu Thr Gly Ser Tyr 305 310 315 320 Ala Thr Phe Ser Asn Leu Leu Giu Ala Pro Lys Leu Giu Val Phe Leu 325 330 335 Lys Thr Thr Pro Asn Tlyr Tyr Gly Asp Ser Ile Lys Asp Leu Leu Ser 340 345 350 Ala Tyr Lys Val Val Leu-Pro Leu Asp Lys Ile Ser Met Pro Ser Ser 355 360 365 Ala Asp Leu Lys Leu Thr Leu Gin Phe Leu Lys Asn Thr Ala Pro Leu 370 375 380 Phe Ser Val Gin Giy Ser Val Asn Leu Gin Giu Gly Thr Phe Ser Leu 385 390 395 400 Tyr Asn Ile Pro Leu Tyr Thr Gin Ser Ala Gin Ile Asn Leu Asp Ile 405 410 415 Ala Gin Giu Tyr Gln Tyr Ile Tyr Ile Asp Thr Ile His Thr Arg Tyr 420 425 430 Ala Asn Met Leu Asp Leu Asp Ala Lys Ile Ala Leu Asp Leu Gly Gin 435 440 445 Lys Asn Leu Ser Leu Asp Ser Leu Val His Lys Ile Gin Val Asn Thr 450 455 460 1371 Asn Asn Asn Ile Asn Met Arg Ser Tyr Asp Pro Asn Asn Thr Gin Giu 465 470 475 480 Asp Pro Gin Thr Asn Phe Thr Leu Asp Leu Lys Ser Leo His Ser Ile 485 490 495 Ile Gin Giu Giy Glu Asn Ser Giu Val Phe Arg Arg Lys Ile Ile Asp 500 505 510 Thr Ile Lys Ala Gin Ser Gio Asp Lys Phe Thr Lys Asp Val Phe Tyr 515 520 525 Ala Thr Giy Asp Thr Leo Lys Ser Leu Ser Leu Ser Phe Asp Phe Ser 530 535 540 Asn Pro Asp His Ile Gin Trp Ser Vai Pro Gin Leo Leu Leu Giu Giy 545 550 555 560 Glu Phe Lys Asp Asn Ala Tyr Thr Phe Lys Ile Lys Asp Leo Lys Lys 565 570 575 Ile Lys Pro Tyr Ser Pro Ile Met Asp Tyr Ile Ala Leo Lys Asp Gly 580 585 590 Ser Leu Glu Val Ser Thr Ser Asp Phe Val Asn Ile Asp Phe Phe Ala 595 600 605 Lys Asp Leo Lys Ilie Asn Leu Pro Ile Tyr Arg Ser Asp Giy Ser His 610 615 620 Phe Asp Ser Phe Ser Leo Phe Gly Ser Ile Asn Lys Asp Gi Ile Ser 625 630 635 640 '00,009.Val Tyr Thr Pro Ser Lys Ser Ile Ser Ile Lys Val Lys Gly Asp Gin **of,645 650 655 .00 Lys Asp Ilie Thr Leu Asn Asn Ile Asp Leu Ser Ile Asp Asp Phe Leo 660 665 670 Asp Ser Lys Met Pro Ala Ile Ala Giy Leu Phe Ser Lys Gbu Arg Lys 675 680 685 Glu Lys Pro Ser Ser Lys Giu Ile Gin Asp Glu Asp Val Phe Ile Ser *690 695 700 Ala Lys Gin Arg Tyr Giu Lys Ala His Lys Ile Ile Pro Ile Ser Thr 705 710 715 720 *Arg Ile His Ala Lys Asp Val Val Le Ile Tyr Lys Lys Met Pro Phe 725 730 .735 Pro Leu Giu Asn Leo Asp Ile Val Ala Gin Asp Asp Arg Val Lys Ile 740 745 750 Asp Gly Asn Tyr Lys Asn Ala Met Ile Met Ala Asp Leo Val His Gly 755 760 765 Ala Leo Tyr Leo Lys Ala His Asn Phe Ser Gly Asp Tyr Ile Asn Thr 770 775 780 Ile Leu Gin Lys Asp Phe Val Giu Gly Gly Leu Phe Thr Leu Ile Gly 785 790 795 800 Ala Leu Glu Asp Gin Val Phe Asn Gly Giu Leu Lys Phe Gin Asn Thr 805 810 815 Ser Leo Lys Asn Phe Ala Leo Met Gin Asn Met Val Asn Leu Ile Asn 820 825 830 Thr Ile Pro Ser Le Ile Val Phe Arg Asn Pro His Leu Gly Ala Asa 835 840 845 Gly Tyr Gin Ile Lys Thr Gly Ser Val Val Phe Gly Ile Thr Lys Glu 850 855 860 Tyr Leu Gly Leu Glu Lys Ile Asp Leu Val Gly Lys Thr Leo Asp Ile 865 870-. 875 880 Ala Gly Asn Gly Ile Ile Giu Leu Asp Lys Asn Lys Leu Asp Leo Asn 885 -,890 895 Leu Giu Val Ser Thr Ile Lys Ala Leo Ser Asn Val Leo Asn Lys Ile 900 905 910 Pro Ilie Val Gly Tyr Leo Val Leu Gly Lys Gly Gly Lys Ile Thr Thr 915 920 925 Asn Val Asn Val Lys Gly Thr Leo Asp Lys Pro Lys Thr Gin Val Thr 930 935 940 Leu Ala Ser Asp Ilie Ilie Gin Ala Pro Phe Lys Ile Leo Arg ArgIle 945 950 955 960 Phe Thr Pro Ilie Asp Ilie Ile Val Asp Glu Vai Lys Lys Asn Ile Asp 965 970 975 Ser Lys Arg Lys Leo Lys 1372 980 INFORMATION FOR SEQ ID NO:1845: SEQUENCE CHARACTERISTICS: LENGTH. 371 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc_feature LOCATION .371 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1845 Arg Pro Phe Arg Ser Leu Ile Arg Ile Thr His Ala Pro Lys Leu Lys 1 5 10 Pro Ser Phe Ala Leu Giu Cys Val Ile Thr Trp Giu Ala Ile Asn Sen 25 Met Giu Ile Thr Leu Phe Asp Pro Ile Asp Ala His Leu His Val Arg 40 Glu Asn Ala Leu Leu Lys Ala Val Leu Giu Tyr Ser Sen Giu Pro Phe 55 Sen Ala Ala Val Ile Met Pro Asn Leu Sen Lys Pro Leu Ile Asp Thr to 65 70 75 Pro Ile Thr Leu Glu Tyr Glu Glu Giu Ile Leu Lys Asn Sen Sen Asn 85 90 too, Phe Lys Pro Leu Met Sen Leu Tyr Phe Asn Asp Gly Leu Thr Leu Glu 100 105 110 Glu Leu Gin Arg Ala Lys Asn Lys Gly Ile Lys Phe Leu Lys Leu Tyr *115 120 125 Pro Lys Gly Met Thr Thn Asn Ala Gin Asn Gly Thr Sen Asp Leu Leu to.130 135 140 Gly Giu Lys Thr Leu Glu Val Leu Glu Asn Ala Gin Lys Leu Gly Phe *145 150 155 160 Ile Leu Cys Val His Ala Giu Gin Ala Gly Phe Cys Leu Asp Lys Giu 165 170 175 Phe Leu Cys His Ser Val Leu Giu Thr Phe Ala Leu Ser Phe Pro Lys 180 185 190 Leu Lys Ile Ile Ile Glu His Leu Ser Asp Trp, Arg Sen Ile Ala Leu 195 200 205 le Glu Lys His Asp Asn Leu Tyr Ala Thr Leu Thr Leu His His Ile 210 215 220 Ser Met Tkir Leu Asp Asp L6eu Leu Gly Gly Sen Leu Asp Pro His Cys 225 230 235 240 Phe Cys Lys Pro Leu Ile Lys Thn Lys Lys Asp Gin Glu Arg Leu Leu 245 250 255 Ser Leu Ala Leu Lys Ala His Pro Lys Ile Sen Phe Gly Ser Asp Sen 260 265 270 Ala Pro His Phe Ile Ser Lys Lys His Ser Ala Asn Ile Pro Ala Gly 275 280 285 Ile Phe Ser Ala Pro Ile Leu Leu Pro Ala Leu Cys Giu Leu Phe Glu 290 295 300 Lys His Asn Ala Leu Giu Asn Leu Gin Ala Phe Ile Ser Asp Asn Ala 305 310 315 320 Lys Lys I Ie Tyr Ala Leu Asp Asn Leu Pro 325 330 Sen Lys Lys Ala His Leu 335 Ser
LYS
Glu 1373 Lys Lys Pro Phe Ile Val Pro Thr His Thr Leu Cys Leu Asn Giu 340 345 350 Ile Ala Ile Leu Arg Gly Gly Glu Thr Leu Ser Trp Asn Leu Gin 355 360 365 Ile Ala 370 INFORMATION FOR SEQ ID NO:1846: SEQUENCE CHARACTERISTICS: LENGTH: 231 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .231 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1846 1Gu Ile Tyr Met Pro Giu Asn Ser Lys Leu Gin Pro Ala
S.
S
S
*SS.
LYS
Leu His Pro 65
LYS
Pro le
LYS
Glu 145 Giu
LYS
Pro Asp Arg 225 Asn Ile Arg Giu Asn Pro Glu Lys 130 Giu Gin Giu Pro Ile 210 Lys Phe Leu 35 Giu Asn Asn Thr Lys 115 Pro Lys Lys Phe Arg 195 Asp Arg Asp Ser Asp Leu Pro Pro 100 Pro Asn Lys Val Asp 180 Gin Glu Phe Pro Val Phe Leu Gly Pro Lys His Val Giu 165 Pro Glu Leu His Vai Leu Phe Val 70 Ala Thr Pro Lys Val 150 Gin Asn Asn Tyr Gin 230 Asp Leu Pro 55 Leu Pro Pro Glu His 135 Glu Lys Gin Asn Gly 215 Glu His His 40 Sen Lys Lys Pro Pro 120 Lys Glu Lys Leu Lys 200 Glu Ser 25 Trp Lys Arg Pro Thr 105 Lys Ala Lys Ile Ser 185 Gly Glu Asn Leu Pro Gly Thr Pro Pro Leu Lys Glu 170 Phe Leu Phe Arg Ile Lys His 75 Leu Pro Lys Lys Giu 155 Glu Leu Asp Gly Asn Leu Ser Ala Thr Pro Lys 140 Glu
LYS
Pro Asn Asp 220 Phe Phe Val Gin Gly Pro Lys 125 Val
LYS
Lys Lys Gin 205 Leu Lys Phe Leu Lys Asp Pro Pro 110 Pro Glu Lys Pro Glu 190 Thr Gly Gly Sen Glu Asn Sen Lys Pro Pro Val Val 160 Lys Ala Arg Ala INFORMATION FOR SEQ ID NO:i847: SEQUENCE CHARACTERISTICS: LENGTH: 206 amino acids TYPE amino acid 1374 TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...206 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1847 Ser Arg Tyr His Pro Arg Gly Phe Ser Gin Leu Pro Lys Leu Lys Leu 1 5 10 Ile Cys Ile Thr Ala Thr Gly Thr Asp Asn Val Asp Ile Lys Ser Ala 25 Lys Ala Leu Gly Ile Glu Val Lys Asn Val Ser Ala Tyr Ser Thr Glu 40 Ser Val Ala Gin His Thr Leu Ala Cys Ala Leu Ser Leu Leu Gly Arg 55 Ile Asn Asp Tyr Asp Arg Tyr Cys Lys Ser Gly Glu Tyr Ser Gin Ser 65 70 75 Asp Ile Phe Thr His Ile Ser Asp Ile Lys Met Gly Leu Ile Lys Gly 90 Gly Gin Trp Gly Val Ile Gly Leu Gly Asn Ile Gly Lys Arg Val Ala 100 105 110 Lys Leu Ala Gin Ala Phe Gly Ala Lys Val Val Tyr Phe Ser Pro Lys 115 120 125 Asp Lys Lys Glu Glu Tyr Glu Arg Leu Ser Leu Glu Glu Leu Leu Lys 130 135 140 Thr Ser Gly Ile Ile Ser Ile His Ala Pro Leu Asn Glu Ser Thr Arg S 145 150 155 160 Asp Leu Ile Ala Leu Lys Glu Leu Gin Set Leu Lys Asp Gly Ala Ile 165 170 175 Leu Ile Asn Val Gly Arg Gly Gly Ile Val Asn Glu Lys Asp Leu Ala 180 185 190 Leu Ile Leu Glu Thr Lys Asp Leu Tyr Tyr Ala Ser Asp Val 195 200 205 INFORMATION FOR SEQ ID NO:1848: SEQUENCE CHARACTERISTICS: LENGTH: 106 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...106 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1848 Ile Leu Glu Asn Leu Arg Ile Tyr Ala Arg Leu Leu Glu Met Ile Leu 1 5 10 1375 Lys Asn Leu Ile Leu Leu Phe Leu Ala Lys Arg Lys Leu Ile Phe Ile 25 Glu Ala Asn Phe Tyr Thr Ile Ser Gly Ser Lys Leu Asn Glu Val Ala 40 Arg Ser Tyr Gin Asp Leu Ala Leu Lys Phe Glu Ala Phe Pro Asn Tyr 55 Glu Phe Ile Trp Ile Thr Asp Gly Ile Gly Trp Leu Asp Ala Lys Ser 70 75 Lys Leu Gln Glu Ala Tyr Lys Ser Val Glu Ile Tyr Asn Leu Ser Tyr 90 Val Asn Asp Phe Ile Ser Lys Val Gin Lys 100 105 INFORMATION FOR SEQ ID NO:1849: SEQUENCE CHARACTERISTICS: LENGTH: 119 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein S"(iii) HYPOTHETICAL: YES ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...119 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1849 C. ys Val Met Leu Met Ala Ile Phe Thr Pro Tyr Ile Leu Ile Leu Lys 1 5 10 Met Met Lys Lys Ser Met Ser Leu Phe Ala Asn Met Gly Leu Glu Gin 25 Ile Phe Cys Asn Arg Asp Ile Lys Asp Leu Asn Asp Phe Val Phe Gly 40 Ile Glu Val Gly Leu Asp Ser Asn Ala Arg Lys Asn Arg Ser Arg Lys 55 Ala Met Glu Asn His Leu Ile Gly Leu Phe Val Gin Ala Gin Leu Asn 65 70 75 Phe Lys Glu Gin Val Asp Ile Arg Glu Phe Glu Asp Leu Arg Gin Ala 90 Phe Gly Asn Asp Thr Lys Lys Phe Asp Phe Val Ile Phe Ser Lys Glu 100 105 110 Lys Thr Tyr Phe His Arg Ser 115 INFORMATION FOR SEQ ID NO:1850: SEQUENCE CHARACTERISTICS: LENGTH: 304 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori 1376 (ix) FEATURE: NAME/KEY: misc-feature LOCATION .304 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i850 Val Ile Asn Ser Lys Thr Gly Leu Leu Thr Ile S 5
*S
S
S
Leu Ala Val Leu Thr Thr Ser Ala Ala Ala 145 Asp
LYS
Ser Asp Asn 225 Ile Lys Giu Phe Leu Gly Gin Ser Gin Lys Arg Pro Leu Giu Arg Asp Tyr Asn 115 Asp Thr 130 Ile Arg Asn Gly Gly Val Asn Pro 195 Met Gly 210 Gin Vai Tyr Giu Giu Asn Arg Phe 275 Asn Ser 290 Lys Tyr Aia Thr Gin Asn 100 Giu Lys Ser Val Met 180
LYS
dly Ile Asp Ala 260 Ala Val Aia Giu Ser Asn Thr Gin Leu Ile Ser Glu 165 Ser Ala Arg Ala Ser 245 Gin Ala Gin Ser Ala Asp Giu 70 Thr Aia Ile Ala Leu 150 Ser Leu Thr Glu Asn 230 Leu Giu Tyr Met Leu Ser Ser Val Giu Ile Pro Gly 135S Asn Leu Asp Gin Ile 215 Leu Asp Leu Asp Met 295 Lys Gin 40 Gin Asn Pro Ile Lys 120 Ile Asn Met Giu Asp 200 His Ile Arg Leu Ser 280 Ile Asp 25 Asp Phe Asp Asn Asp 105 Leu Phe Val Lys Ala 185 Phe Gin Asp Asp Lys 265 Gin Asp Leu Thr Thr Val Lys Ser Asp Asn Phe Tyr 170 Lys Phe Glu Gly Ala 250 Thr Ile Giy Leu Leu Phe Tyr Asn Ile Ser Pro Ala Leu Lys Glu Asp Gly Val 140 Ser Tyr 155 Gly Leu Leu Ser Tyr Giy Gly Ile 220 Gly Asn 235 Lys Ser Arg Tyr Ser Lys Lys Ser Met Gly Gly Ile Giu Tkxr 125 Giy Ser Ser Ser Ser 205 Phe Ala Leu Asn Ala 285 Gly Ala Ser Val Val Ile Phe 110 Arg Asp Val Leu Ala 190 Asp Ser Lys Thr Ile 270 Asn
S.
*5 Gin Ala Ala Ala Lys Lys Asn 300 INFORMATION FOR SEQ ID NO:1851: SEQUENCE CHARACTERISTICS: LENGTH: 129 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .129 1377 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i851 Arg Asn Ile Met Gin Tyr Ala Asn Ala Tyr Gin Ala Tyr Gin His Asn 1 5 10 Arg Val Ser Val Glu Ser Pro Ala Lys Leu Ile Giu Met Leu Tyr Giu 25 Gly Ile Leu Axg Phe Ser Ser Gin Ala Lys Arg Cys Ile Giu Asn Giu 40 Asp Ile Glu Lys Lys Ile Tyr Tyr Ile Asn Arg Vai Thr Asp Ile Phe 55 Thr Glu Leu Leu Asn Ile Leu Asp Tyr Giu Lys Gly Gly Lys Val Ala 70 75 Val Tyr Leu Thr Gly Leu Tyr Thr His Gin Ile Lys Vai Leu Thr Gin 90 Ala Asn Val Glu Asn Asp Ala Ser Lys Ile Asp Leu Vai Leu Asn Val 100 105 110 Ala Arg Gly Leu Leu Giu Ala Trp Arg Glu Ile His Ser Asp Giu Leu 115 120 125 Ala INFORMATION FOR SEQ ID NO:1852: SEQUENCE CHARACTERISTICS: LENGTH: 83 amino acids TYPE: amino acid :9 TOPOLOGY: linear MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 83 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1852 Phe Asp Asp Leu Tyr Gly Ser Asn Ser Leu Pro Phe Tyr Pro Arg Val Thr Pro Val Lys Phe Pro Thr Phe Lys Trp, Ala Leu Leu Lys Ala Leu 25 Ile Lys Asp Asp Phe Pro Thr Leu Gly Trp Pro Thr Arg Ala Thr Met 40 Ile Sen Phe Ile Gly Phe Giu Cys Sen Ala Leu Lys Val Phe Leu Ile so 55 Phe Gly Tyr Ile Vai Phe Lys Ser Trp His Tyr Ser Ala Ile Arg Leu 70 75 le Val Ile INFORMATION FOR SEQ ID NO:1853: SEQUENCE CHARACTERISTICS: LENGTH: 220 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein 1378 (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAMdE/KEY: riscjfeature LOCATION .220 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1853 Lys Arg Asp Lys Asn Val Lys Met Arg Lys Gly Arg Val Met Leu Cys 1 5 10 Val Phe Asp Ile Giu Thr Ile Pro Asn Ile Sen Leu Cys Lys Giu His 25 Phe Gin Leu Lys Giu Asp Asp Ala Leu Lys Ile Cys Glu Tnp Ser Phe 40 Glu Lys Gin Lys Glu Lys Ser Gly Sen Giu Phe Leu Pro Leu Tyr Leu 55 His Gu Ilie Ile Se Ile Ala Ala Val Ile Gly Asp Asp Tyr Giy Gin 70 75 Phe Ile Lys Val Gly Asn Phe Giy Gin Lys His Giu Asn Lys Giu Asp 90 Phe Ala Ser Giu Lys Giu Leu Leu Giu Asp Phe Phe Lys Tyr Phe Asn 100 105 110 Glu Lys Gin Pro Arg Leu Ile Ser Phe Asn Gly Arg Giy Phe Asp Ile PoLu115 120 125 PoLuLeu Thr Leu Lys Ala Leu Lys Tyr Asn Leu Thr Leu Asp Ala 130 135 140 Phe Tyr Sen Gin Giu Asn Lys Trp Giu Asn Tyr Ang Ala Arg Tyr Ser 145 150 155 160 Giu Gin Phe His Leu Asp Leu Met Asp Sen Leu Ser His Tyr Gly Sen 165 170 175 *Val Arg Gly Leu Asn Leu Asn Gly Val Cys Ser Met Thr Asn Ile Pro Gy ys ISe18 185 190 GlyLysPheAsp Val Sen Gly Asp Leu Val His Ala Ile Tyr Tyr Asn 195 200 205 Pro His Leu .Arg Pro Lys Gly Gly Lys Arg His Tyr 210 215 220 INFORMATION FOR SEQ ID NO:1854: SEQUENCE CHARACTERISTICS: 999 LENGTH: 254 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE:- ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc_feature LOCATION .254 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1854 Arg The Lys Ala Ang Ile Val Ang Phe Phe Ile Phe Leu Ile Leu Ile 1 5 10 Cys Pro Leu Ile Cys Pro Leu Met Ser Ala Asp Ser Ala Leu Pro Ser 25 1379 Val Asn Leu Ser Leu Asn Ala Pro Ser Asp Pro Lys Gin Leu Val Thr 40 Tbr Leu Asn 'Val Ile Ala Leu Leu Thr Leu Leu Val Leu Ala Pro Ser 55 Leu Ile Leu Val Met Thr Ser Phe Thr Arg Leu Ile Val Val Phe Ser 70 75 Phe Leu Arg Thr Ala Leu Gly Thr Gin Gin Thr Pro Pro Thr Gin Ile 90 Leu Val Ser Leu Ser Leu Ile Leu Thr Phe Phe Ile Met Giu Pro Ser 100 105 110 Leu Lys Lys Ala Tyr Asp Thr Gly Ile Lys Pro Tyr Met Asp Lys Lys 115 120 125 Ile Ser Tyr Thr Giu Ala Phe Giu Lys Ser Thr Leu Pro Phe Lys Glu 130 135 140 Phe Met Leu Lys Asn Thr Arg Giu Lys Asp Leu Ala Leu Phe Phe Arg 145 150 155 160 Ile Arg Asn Leu Pro Asn Pro Lys Thr Pro Asp Asp Val Ser Leu Ser 165 170 175 Val Leu Ile Pro Ala Phe Met Ile Ser Giu Leu Lys Thr Ala Phe Gin 180 185 190 Ile Gly Phe Leu Leu Tyr Leu Pro Phe Leu Val Ile Asp Met Val Ile 195 200 205 *Ser Ser Ile Leu Met Ala Met Gly Met Met Met Leu Pro Pro Val Met 210 215 220 I le Ser Leu Pro Phe Lys Ile Leu Val Phe Ile Leu Val Asp Gly Phe 225 230 235 240 Asn Leu LuTrG Asn Leu Val Ala Ser Phe Lys Met Val :245 250 INFORMATION FOR SEQ ID NO:185S: SEQUENCE CHARACTERISTICS: LEGTH: 614 amino acids TYPE: amino acid TOPOLOGY: linear 0000 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc,.feature LOCATION .614 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i855 Lys Trp Gly Ile Leu Pro Gly Leu Pro Val Asp Lys Met Giu Val Ser 1 5 -10 Leu Ile His Lys Asp His Gin Ile Thr Ile Ile Asp Leu Pro Gly Thr 25 Tyr Ala Leu Asn Asp Phe Thr Thr Giu Giu Lys Val Thr Lys Asp Phe 40 Leu Glu Lys Gly Gin Tyr Asn Leu Ile Leu Asn Vai Val Asp Ser Thr 55 Asn Leu Giu Arg Asn Leu Ala Leu Ser Ala Gin Leu Leu Asp Thr Asn 70 75 Lys Lys Met Leu Leu Ala Leu Asn Met Trp Asp Giu Ala Lys Lys Giu 90 Gly Ile Asn Ile Asn Thr Giu Lys Leu Ser Gin Giu Leu Gly Val Val 100 105 110 Cys Val Pro Thr Ser Ala Arg Ser Lys Giu Asp Arg Leu Asri Thr Giu 1380 Leu Asn 145 Tyr Lys Met Ile Glu 225 Asn Gly Ile Leu Pro 305 Arg Gly Giy Tyr Leu 385 Lys Lys Ala Met Leu 465 Leu Tyr Val Leu Phe 545 Phe Thr Ile Ala Leu 130 Glu Ser Gin His Phe 210 Glu Glu Ala Ser Asp 290 Leu Thr Phe Ser Ile 370 Ser Ser Ile Lys 450 Ser Asp Leu Ser Gly 530 Arg Ile Phe Phe Thr 610 115 Leu Asn Gin Asn Gin 195 Ser Gly Asp Thr Leu 275 Gly Ile Leu Met Pho 355 Leu Val Arg Leu Leu 435 Thr Ser Lys Glu Leu 515 Val Glu Val Gly Thr 595 Gln Asp Ile Ser Ala 180 Arg Leu Phe Leu Val 260 Leu Ile Thr Gln Ser 340 Phe Gly Phe Phe Ser 420 Ile Tyr Glu Lys Lys 500 Val Leu Ile Phe Arg 580 Thr Ile Glu Lys Ala 165 Ser Tyr Ser Lys Ala 245 Ser Glu Leu Gly Asn 325 Cys Pro Ala Lys Pro 405 Tyr Trp Lys Ala Asn 485 Val Thr Phe Ile Val 565 Glu Val Leu Ile Val 135 Val Pro 150 Gin Arg Phe Glu Gly Ile Phe Leu 215 Ile Leu 230 Ser Leu Phe Leu Thr Thr His Lys 295 Phe Gly 310 Tyr Asn Ser Ala Ser Ser Vai Val 375 Gly Gin 390 Ser Trp Leu Lys Phe Met Gin Glu 455 Lys Glu 470 Leu Lys Phe Asn Gly Phe Ser Leu 535 Arg Lys 550 Met Phe Ala Gly Val Ala Val 120 Arg Ser Ile His Pho 200 Ile Ser Val Pro Gly 280 Phe Cys Glu Arg Ser 360 Ala Thr Arg Lys Ser 440 Ser Glu Asn Pro Met 520 Gly Glu Tyr Gly Tyr 600 Leu Gin Ala Thr 185 Ile Gly Asp Gly Leu 265 Tyr Gly Ser Arg Leu 345 Ala Leu Glu Met Ala 425.
Gin Leu Lys Ser Met 505 Ala Asp Val Ile Ile 585 Ala Tyr Ser Lys 170 Tyr Phe Gly Ser Asp 250 Ile Met Leu Val Leu 330 Pro Gly Val Ser Val 410 Gly Tyr Leu Leu Val 490 Asp Lys Gin Ser Pro 570 Lys Phe Ser Phe 155 Ser Lys Leu Gly Ile 235 Gly Val Ser His Pro 315 Ile Ile Phe Met Phe 395 Tyr Thr Pro Val Lys 475 Val Phe Glu Asn Val 555 Cys Pho Ser Gin 140 Lys Val Ile Gly Val 220 Lys Ile Vai Arg Gly 300 Ala Thr Tyr Val Ala 380 Ile Phe Tyr Lys Gin 460 Glu Gly Asp Val Glu 540 Pro Phe Val Leu 125 Asn Glu Ile Asp Phe 205 Gin Glu Ile Leu Val 285 Lys Tyr Leu Val Leu 365 Lys Met Ser Ile Asn 445 Lys Leu Arg Trp Vai 525 Lys Ser Ala Ala Ile 605 Thr Ser Ser Lys 190 Met Lys Asn Gly Tyr 270 Ala Ser Met Phe Leu 350 Phe Leu Glu Ile Leu 430 Asp Asn Lys Gly Arg 510 Val Ser Gly Ala Tyr 590 Ala Thr Leu Glu 175 Ile Phe Ala Val Gly 255 Phe Phe Phe Ala Val 335 Phe Cys Leu Met Tyr 415 Val Ala Ala Thr Gly 495 Leu Ser Asp Ile Thr 575 Leu Phe Asn Lys 160 Asn Leu Ile Leu Ala 240 Val Gly Leu Ile Thr 320 Ile Val Ile Lys Pro 400 Thr Gly Ala Asn Glu 480 Ala Ser Thr Ala Ala 560 Ile Phe Tyr 1381 INFORMATION FOR SEQ ID NO:18 56 SEQUENCE CHARACTERISTICS: LENGTH: 325 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .325 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1856 Met Lys Arg Ile Leu Val Ser Leu Ala Val Leu Ser His Sen Ala His 1 5 10 Ala Val Lys Thr His Asn Leu Glu Arg Val Giu Ala Sen Gly Val Ala 25 Asn Asp Lys Glu Ala Pro Leu Sen Trp Ang Sen Lys Glu Val Arg Asn 40 Tyr Met Gly Sen Arg Thr Val Ile Ser Asn Lys Gin Lou Thr Lys Ser so 55 *Ala Asn Gin Ser Ile Glu Giu Ala Leu Gin Asn Val Pro Gly Val His 9965 70 75 Ile Arg Asn Ser Thn Gly Ile Gly Ala Val Pro Se Ile Ser Ile Arg 90 Gly Phe Giy Ala Gly Giy Pro Gly His Sen Asn Thr Gly Met Ile Leu 100 105 110 Val Asn Gly Ile Pro Ile Tyr Val Ala Pro Tyr Val Giu Ile Gly Thr 115 120 125 Val Ile Phe Pro Val Thr Phe Gin Sen Val Asp Arg Ile Sen Val Thr 130 135 140 Lys Gly Gly Giu Ser Val Ang Tyr Gly Pro Asn Ala Phe Gly Gly Val 145 150 155 160 Ile Asn Ile Ile Thn Lys Gly Ile Pro Thr Asn Trp Giu Sen Gin Val 165 170 175 *Ser Giu Arg Thn Thr Phe Trp Gly Lys Ser Giu Asn Gly Gly Phe Phe 180 185 190 Asn Gin Asn Ser Lys Asn Ile Asp Lys Ser Leu Val Asn Asn Met Leu 195 200 205 Phe Asn Thr Tyr Leu Arg Thn Gly Gly Met Met Asn Lys His Phe Gly 210 215 220 Ile Gin Ala Gin Val Asn Trp Leu Lys Gly Gin Gly Phe Arg Tyr Asn 225 430 235 240 Ser Pro Thr Asp Ile Gin Asn Tyr Met Lou Asp Sen Lou Tyr Gin Ile 245 250 255 Asn Asp Ser Msn Lys Ile Thr Ala Phe Phe Gin Tyr Tyr Ser Tyr Phe 260 265 270 Leu Thr Asp Pro Gly Ser Lou Gly Ile Ala Ala Tyr Asn Gin Asn Ang 275 280 285 Phe Gin Msn Msn Arg Pro Asn Asn Asp Lys Ser Gly Arg Ala Lys Ang 290 295 300 Tnp Gly Ala Val Tyr Gin Asn Phe Phe Gly Asp Thn Asp Ang Val Gly 305 310 315 320 dly Gly Phe His Phe 325 INFORMATION FOR SEQ ID NO:1857: 1382 SEQUENCE CHARACTERISTICS: LENGTH: 797 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NME/KEY: misc-feature LOCATION 797 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1857 Arg Leu Lys Pro Asn Val Ile Giu Arg Arg Met Lou Giu Lys Leu Leu 1 5 10 Ser Ala Ile Lys Gin Lys Val Ser Asn Tyr Phe Leu Gly Val Leu Pro 25 Lys Sen Tyr Sen Met Sor Glu Glu Asn Asn Ile Leu Gly Leu Tyr Asp 40 0 Giu His Phe Lou Lou Thn Lys Asn Giu Asn Leu Val Gly Ile Lou Arg *50 55 Lou Giu Gly Val Sen Tyr Thr His Lou Son Thr Giu Gin Lou Gin Asp 7 58 .**Leu Phe Thr Glu Arg Gin Met Ala Leu Asp Sen Leu Giu Lys Val Val 90 Ala Arg Leu Val Val Lys Arg Arg Lys Ile Asp Tyr Lys Gin Sor Ile 100 105 110 *Gin Sen Asp Sen Gin Tyr Lou Gin Ala Ile Lou Asn Gin Phe Giu Asn *115 120 125 000, Lys Giu Val Ty Giu Asn Gin Tyr Phe Lou Val Lou Giu Ser Thr His 130 135 140 Ser Lou His Gly Val Leu Giu*His Lys Lys Lys Sen Phe Met His Ala 145 I50 155 160 ***Asn Arg Giu Asn Phe Lys Asp Ile Lou Sen Tyr Lys Ala His Pho Lou 'Sa**165 170 175 Gin Glu Thn Lou Lys Ser Lou Giu Ile Gin Lou Lys Asn Tyr Aia Pro 180 185 190 :::Lys Lou Lou Asn Sen Lys Giu Vai Lou Asn Pho Tyr Ala Giu Tyr Ile 195 200 2 Asn Gly Phe Giu Lou Pro Lou Lys Pro Lou Val Gly Gly Tyn Lou Sen 210 215 220 Asp Ser Tyr Ile Ala Sen Ser Ile Thr Ph. Giu Lys Asp Tyr Pho Ile 225 230 235 240 Gin Giu Sor Phe Asn Gin Lys Thr Tyr Asn Arg Leu 1le Gly Ile Lys 245 250 255 Ala Tyr Gin Son Giu Arg Ile Thr Ser Ile Ala Val Gly Ala Lou Lou 260 265 270 Tyr Gin Giu Thr Pro Lou Asp Ile Ile Phe Sor Ile Glu Pro Met Sen 275 280 285 Val Asn Lys Thr Leu Ser Ph. Leu Lys Giu Ang Ala Lys Ph. Sen Met 290 295 300 Ser Asn Lou Val Lys Asn Gin Lou Lou Giu Tyr Gin Glu Lou Vai Lys 305 310 315 320 Thn Lys Arg Leu Sen Met Gin Lys Phe Ala Lou Asn Val Lou Ile Lys 325 330 335 Ala Pro Ser Lou Giu Asp Lou Asp Ala Gin Thr Sen Lou Ile Leu Gly 340 345 350 Lou Lou Ph. Lys Gin Asn Leu Vai Gly Val Ile Giu Thr Phe Gly Lou 355 360 365 1383 Lys Gly Gly Tyr Phe Ser Phe Phe Pro Giu Arg Ile His Leu Asn His 370 375 380 Arg Leu Arg Phe Leu Thr Ser Lys Ala Leu Ala Cys Leu Met Val Phe 385 390 395 400 Giu Arg Gln Asn Leu dly Phe Lys Ala Asn Ser Trp Gly Asn Ser Pro 405 410 415 Leu Ser Val Phe Lys Asn Leu Asp Tyr Ser Pro Phe Leu Phe Asn Phe 420 425 430 His Asn Gin Giu Val Ser His Asn Asn Ala Lys Giu Ile Ala Arg Val 435 440 445 Asn Gly His Thr Leu Val Ile Gly Ala Thr Gly Ser Gly Lys Ser Thr 450 455 460 Leu Ile Ser Tyr Leu Met Met Ser Ala Leu Lys Tyr Gin Asn Met Arg 465 470 475 480 Leu Leu Ala Phe Asp Arg Met Gin Giy Leu Tyr Ser Phe Thr Glu Phe 485 490 495 Phe Lys Gly His Tyr His Asp Gly Gin Ser Phe Ser Ile Asn Pro Phe 500 505 510 Cys Leu Giu Pro Asn Leu Gin Asn Leu Giu Phe Leu Gin Ser Phe Phe 515 520 525 Leu Ser Met Leu Asp Leu Ala Pro Ser Arg Asp Lys Giu Ala Leu Giu 530 535 540 Asp Met Asn Ala Ile Ser Gly Ala Ile Lys Ser Leu Tyr Giu Thr Leu 545 550 555 560 Tyr Pro Lys Asp Phe Ser Leu Leu Asp Phe Lys Giu Thr Leu Lys Arg 565 570 575 Thr Ser Ser Asn Gin Leu Gly Leu Ser Leu Giu Pro Tyr Leu Asn Asn 580 585 590 Pro Leu Phe Asn Ala Leu Asn Asp Ala Phe Asn Ser Asn Ala Phe Leu *9595 600 605 Asn Val Ile Asn Leu Asp Ala Ile Thr Gin Asn Pro Lys Asp Leu Gly 610 615 620 Leu Leu Ala Tyr Tyr Leu Phe Tyr Lys Ile Leu Giu Giu Ser Arg Lys 625 630 635 640 Asn Asp Ser Gly Phe Leu Val Phe Leu Asp Giu Phe Lys Ser Tyr Val 645 650 655 Giu Asn Asp Leu Leu Asn Thr Lys Ile Asn Ala Leu Ile Thr Gin Ala Aa660 665 670 Arg Lys AaAsn Gly Val Val Val Leu Ala Led Gin Asp Ile Tyr Gin 675 680 685 Leu Ser Gly Val Lys Asn Ala His Ser Phe Leu Ser Asn Met Gly Thr 690 695 700 *Leu Ile Leu Tyr Pro Gin Lys Asn Ala Arg Giu Leu Lys His Asn Phe 705 710 715 720 Asn Val Pro Leu Ser Giu Thr Giu Ile Ser Phe Leu Glu Asn Thr Pro 725 730 735 Leu Tyr Ala Arg Gin Vai Leu Val Lys Asn Leu Giy Asn Gly Ser Ser 740 745 750 Asn Met Ile Asp Val Ser Leu Giu Gly Leu Gly Cys Tyr Leu Lys Ile 755 760 765 Phe Asn Ser Asp Ser Ser His Val Asn Lys Val Lys Ala Leu Gin Lys 770 1775 780 Asp Tyr Pro Thr Giu Trp Arg Giu Lys Leu Leu Lys Ser 785 790 795 INFORMATION FOR SEQ ID NO:i858: SEQUENCE CHARACTERISTICS: LENGTH: 529 amino acids TYPE: amino acid.
TOPOLOGY: linear (ii) MOLECULE TYPE: protein 1384 (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_ feature LOCATION 1...529 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1858 Lys Met Ile Leu Lys Ser Ser Ile Asp Arg Leu Leu Gin Thr Ile Asp 1 5 10 Ile Val Glu Val Ile Ser Ser Tyr Val Asp Leu Arg Lys Ser Gly Ser 25 Asn Tyr Met Ala Cys Cys Pro Phe His Glu Glu Arg Ser Ala Ser Phe 40 Ser Val Asn Gin Val Lys Gly Phe Tyr Tyr Cys Phe Gly Cys Gly Ala 55 Ser Gly Asp Ser Ile Lys Phe Val Met Ala Phe Glu Lys Leu Ser Phe 70 75 Val Glu Ala Leu Glu Lys Leu Ala His Arg Phe Asn Ile Ala Leu Glu 85 90 Tyr Asp Lys Gly Val Tyr Tyr Asp His Lys Glu Asp Tyr His Leu Leu *0 100 105 110 Glu Met Val Ser Ser Leu Tyr Gin Glu Glu Leu Phe Asn Ala Pro Phe 115 120 125 Phe Leu Asn Tyr Leu Gin Lys Arg Gly Leu Ser Met Glu Sen Ile Lys 130 135 140 Ala Phe Lys Leu Gly Leu Cys Thr Asn Lys Ile Asp Tyr Gly Ile Glu 145 150 155 160 Asn Lys Gly Leu Asn Lys Asp Lys Leu Ile Glu Leu Gly Val Leu Gly 165 170 175 Lys Ser Asp Lys Glu Asp Lys Thr Tyr Leu Arg Phe Leu Asp Arg Ile 180 185 190 Met Phe Pro Ile Tyr Ser Pro Ser Ala Gin Val Val Gly Phe Gly Gly 195 200 205 Arg Thr Leu Lys Glu Lys Ala Ala Lys Tyr Ile Asn Ser Pro Gin Asn 210 215 .220 Lys Leu Phe Asp Lys Ser Ser Leu Leu Tyr Gly Tyr His Leu Ala Lys 225 230 235 240 Glu His Ile Tyr Lys Gin Lys Gin Val Ile Val Thr Glu Gly Tyr Leu 245 250 255 Asp Val Ile Leu Leu His Gin Ala Gly Phe Lys Asn Ala Ile Ala Thr 260 265 270 Leu Gly Thr Ala Leu Thr Pro Ser His Leu Pro Leu Leu Lys Lys Gly 275 280 285 Asp Pro Glu Ile Leu Leu Ser Tyr Asp Gly Asp Lys Ala Gly Arg Asn 290 295 300 Ala Ala Tyr Lys Ala Ser Leu Met Leu Ala Lys Glu Gin Arg Lys Gly 305 310 315 320 Gly Val Ile Leu Phe Giu Asn Asn Leu Asp Pro Ala Asp Met Ile Ala 325 330 335 Asn His Gin Ile Glu Thr Leu Lys Asn Trp Leu Ser Arg Pro Ile Ala 340 345 350 Phe Ile Glu Phe Val Leu Arg His Met Ala Gly Ser Tyr Leu Leu Asp 355 360 365 Asp Pro Leu Glu Lys Asp Lys Ala Leu Lys Glu Met Leu Giy Phe Leu 370 375 380 Lys Asn Phe Ser Leu Leu Leu Gin Asn Giu Tyr Lys Pro Leu Ile Ala 385 390 395 400 Thr Leu Leu Gin Ala Pro Leu His Val Leu Gly Ile Arg Glu Pro Val 405 410 415 Ser Phe Gin Pro Phe Tyr Pro Lys Thr Glu Lys Pro Asn Arg Pro Gln 420 425 430 1385 Lys Phe Ala His Val Ser Ser Met Pro Ser Leu Glu Phe Leu Giu 435 440 445 Leu Val Ile Arg Tyr Leu Leu Giu Asp Arg Ser Leu Leu Asp Leu Ala 450 455 460 Val Gly Tyr Ile His Ser Gly Val Phe Leu His Lys Lys Gln Giu Phe 465 470 475 480 Asp Ala Leu Cys; Gin Glu Lys Leu Asp Asp Pro Lys Leu Val Ala Leu 485 490 495 Leu Leu Asp Ala Asn Leu Pro Leu Lys Lys Gly Gly Phe Giu Lys Glu 500 505 510 Leu Arg Leu Leu Ile Leu Arg Tyr Phe Glu Pro Pro Thr Gin Arg Asn 515 520 525 Pro INFORMATION FOR SEQ ID NO:i859: SEQUENCE CHARACTERISTICS: LENGTH: 430 amino acids TYPE: amino acid TOPOLOGY: linear *9090(ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES .9 P.(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .430 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1859 Leu Arg Giy His Arg Arg Thr Tyr Ile Gly Ser Met Pro Gly Arg Ile 1 5 10 Vai Gin Gly Leu Ile Giu Ala Lys Lys Met Asn Pro Val Met Val Leu 25 Asp Glu Ile Asp Lys Val Asp Arg Sen Val Arg'Gly Asp Pro Ala Sen 9..35 40 Ala Leu Leu Glu Ile Leu Asp Pro Glu Gin Msn Ile Ala Phe Arg Asp 55 His Tyr Ala Asn Phe Sen Ile Asp Leu Ser Gin Val Ile Phe Ile Ala 70 75 Thr Ala Msn Mn Ile Asp Ang Ile Pro Ala Pro Leu Ang Asp Ang Met 8s 90 Glu Phe Ile Ser Val Ser Sen Tyr Thr Pro Ser Giu Lys Giu Giu Ile 100 105 110 Ala Lys Asn Tyr Leu Ile Pro Gin Glu Leu Giu Lys His Ala Leu Lys 115 120 12*5 Pro Ser Glu Val Asp Ile Sen His Giu Cys Leu Lys Leu Ile Ile Glu .130 135 140 Lys Tyr Thr Arg Giu Ala Gly Val Arg Asp Leu Ang Arg Gin Ile Ala 145 150 155 160 Thr Ile Met Arg Lys Ala Ala Leu Lys Tyr Leu Giu Asp Msn Pro His 165 170 175 Lys Lys Gly Ang Thr Lys Lys Sen Giu Asp Lys Asp Lys Lys Gly Gly 180 185 190 Asn Giu Glu Asn Giu Lys Ang Gly Giu Ser Lys Asp Phe Cys Val Ser 195 200 205 Ile Thr Pro Asp Asn Leu Lys Glu Tyr Leu Glu Ang Met Val Phe Glu 210 215 220 Ile Asp Pro Ile Asp Glu Giu Asn Lys Ile Gly Ile Val Asn Gly Leu 1386 225 230 235 240 Ala Trp Thr Pro Val Gly Gly Asp Val Leu Lys Ile Glu Ala Val Lys 245 250 255 Ile Arg Gly Lys Gly Giu Leu Lys Leu Thr Gly Ser Leu Gly Asp Val 260 265 270 Met Lys Glu Ser Ala Ile Ile Ala Phe Ser Val Val Lys Val Leu Leu 275 280 285 Asp Asn Glu Thr Leu Lys Val Pro Lys Ile Pro Ser Glu Thr Asp Ala 290 295 300 Glu Asn Lys Lys Lys Lys Lys Val Leu Lys Val Tyr Asn Ala Tyr Asp 305 310 315 320 Leu His Leu His Val Pro Glu Gly Ala Thr Pro Lys Asp Gly Pro Ser 325 330 335 Ala Gly Ile Ala Met Ala Ser Val Met Ala Ser Ile Leu Cys Asp Arg 340 345 350 Ala Ile Arg Ser Glu Val Ala Met Thr Gly Glu Leu Thr Leu Ser Gly 355 360 365 Glu Val Leu Pro Ile Gly Gly Leu Lys Glu Lys Leu Ile Ala Ala Phe 370 375 380 Lys Ala Gly Ile Lys Thr Ala Leu Ile Pro Val Lys Asn Tyr Glu Arg 385 390 395 400 Asp Leu Asp Glu Ile Pro Thr Glu Val Arg Glu Asn Leu Asn Ile Val 405 410 415 Ala Val Lys Asn Ile Ala Glu Val Leu Glu Lys Thr Leu Leu 'Po*420 425 430 INFORMATION FOR SEQ ID NO:1860: 0.0 SEQUENCE CHARACTERISTICS: LENGTH: 272 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1...272 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1860 Lys Arg Tyr Arg Lys Thr Ala Leu Leu Arg Leu Asp Asn Gly Asp Lys 1 5 10 Leu Ser Leu Met Arg Glu Phe Phe Lys Ser Val Arg Gly Phe Leu Asn 25 Leu Leu Arg Met Ile Phe Pro Glu Arg Phe Gin Asn Ala Phe Leu Gly 40 Leu Ser Glu Leu Phe Tyr'Tyr Ala Ser Ser Leu Ser Phe Tyr Thr Ile 55 Leu Ser Leu Ser Pro Ile Leu Leu Phe Val Phe Ser Leu Phe Val Ser 70 75 His Tyr Leu Gin Ala His Ser Gly Glu Met Glu Ala Leu Ile Phe Pro 90 Asn Ala Pro Lys Leu Ile Gly Ala Ile Lys Asp Phe Leu Glu Asn Phe 100 105 110 Lys Lys Thr Asp Met Thr Leu Gly Thr Leu Glu Glu Val Ser Ile-Val 115 120 -125 Val Ala Leu Val Leu Phe Cys Glu Asn Tyr Arg Ser Ile Ala Ser Lys 130 135 140 Ile 145 Ile Leu Asp Ala His 225 His His Arg Phe Phe Leu Phe 215 Leu Ser Tyr Asp G ly Asp His 200 Thr Trp Thr Gly Tyr Thr Ile 185 Val Ile Val Leu Ser 265 1387 His Phe Leu Val Ile Gin Arg Trp Thr Asn 220 Phe Thr 235 Met Cys Phe Pro INFORMATION FOR SEQ ID N0:1861: SEQUENCE CHARACTERISTICS: LENGTH: 249 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-foaturo LOCATION .249 (xi) SEQUENCE DESCRIPTION: SEQ ID N0:1861.
Val Gly Vat Vat Met Ile Lys Lys Thr Lou Atla Ser 1 Leu Thr Gin Lys Thr Ile Lou
LYS
Ala 145 Gtu Arg Thr Ser Arg Leu Lou Val Lys Thr Gly 130 Phe Gtu Gtu Lou 5 Lou Met Sen Sor Val Lys 35 Gin Ser Tyr Vat Lys Asp Lou Asn Thr Tyr Thr Pro 100 Lou Ile Pro 115 Vat Lys Ilo Thr Leu Lys Ser Vat Leu 165 Lou Val Ala 180 His Asp Phe 195 Vat Lou Tyr His Lys Met 55 Lys Lys Phe Asp Gtu Thr Gly Ala Phe Tyr 135 Thr Lou 150 Lou Lys Lys Asp Asp Ala Asn Gin 40 Ala Pro Tyr Trp, Lou 120 Ile Lys G lu Tyr Ile Ala Gin Lys Ala Ala Asp 105 Asp Ser Sen Lys Aia 185 Phe Cys G lu Lou Lou Leu Glu G lu Thr 140 Lou Pro Lou Asp Vat Val Ito Asp Asp Vat Lys Tyr 125; Gin Pro Lys Gin Ala Lou Gty Pro Ile Ala Lou Asn Lou Asp Glu Asn Cys Gly Sen Asn Sen Asn Lys Val Ser 160 Val Arg 175 Gly -Asp Asn Ser 200 205 Gtn Glu Gin Gln Ala Lys Val Lou Gin Msn Ala Gin Lys Phe Gly Thr 13988 210 215 220 Giu Trp Ile Ile Leu Pro Asn Ser Leu Tyr Gly Thr Trp Giu Asp Giy 225 230 235 240 Pro Ile Lys Ala Trp Gin Asn Lys Lys 245 INFORMATION FOR SEQ ID NO:1B62: SEQUENCE CHARACTERISTICS: LENGTH: 363 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobactor pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 363 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1862 His Phe Val Leu Lou 65 Pro Pro
LYS
Leu Arg 145 Asp Lou le Val Phe 225 Ile
LYS
Asp Ser Asp Lys Giu Asp le Arg Ile Ala 50 Gly Val Pho Ile Lys Asn Asn Ala 115 Ala Pro 130 Gin Asn Leu Ile LYS LYS Ile Ala 195 His Met 210 Ile Giu Leu Ile Glu Val Leu Ala 275 Gly Pro 290 Lys Phe Asp Leu Leu 5 Leu Lys Cys Lys Asp 20 Asn Asp Lys Lou Gly 40 Lou Lys His Ala Phe 55 Val Val Pro Ser Tyr 70 Asp Glu Vai Ile Ile 85 Arg Sen Thr Asp Ala 100 Lys Leu Ala Phe Ser 120 Lys Thr Lys Ile Tyr 135 Arg Ser Lou Cys Lou 150 His Ala Phe Cys Lys 165 Ile Ala Trp Lys Lou 180 Ser Lys Lou Asn Ala 200 His Ser Gly Gly Son 215 Lou Ile Ala Ile Lou 230 Cys Giy Pro Gly Giu 245 Pro Phe Ala His Leu 260 Lys Lou Cys Ala Asn 280 Lou His Val Asn Ala 295 Giy Lys 25 Asp Lou Thr Giu Lou 105 Lou Ser
LYS
Asp Lys 185 Asn Ser His Arg 265 Lou Lou Gly 10 Giu Phe Giu Thr Asp 90 Ile Arg Trp Thn 170 Asp Val Pro Giu Lys 250 Asp Sor Phe Val Asn Ile
LYS
Pro 75 Asn Phe Lys Lou Glu Asp Lys Asp Val Lys 235 Ala Thr Val Asp Met Ser Lou Gly Ile His Leu Sen Tyr 140 Tyr Leu Sen Lou Lou 220 Lou Thr Ser Cys Asn 300 Asp Gin Val Val Ala Lou Phe Ile 125 Gin Glu Pro Lys Lou 205 Pro Son Glu His Ile 285 Gin Phe Val Gly 1s Lys Val Phe Ile Pro Ala Giu Val Tyr Lou Giu Phe Ala Thr Thr Son Asn Phe 110 Pro Tyr Ile Lys Arg Vai Tyr Asn Lou 160 Asn Ala Gin 175 Giu Arg Sor 190 Trp Ile Gly Ala Ser His Cys Giu Ile 240 Giu Lou Leu 255 Ser Leu Val 270 GJly Asn Ala Sen Ile Gly Phe 305 Asn Gly Thr Tyr Glu Leo
LYS
1389 Pro Asn Giu Leu Thr Ala Ser Ile Ala Arg Trp Arg Pro Phe 310 315 320 Gin Phe Leo Gly Ile Thr Pro Pro Asn Gly Ser Asn Asp Met 325 330 335 Ile Asp Ile Gin Lys Glu Ser Glu Lys Ile Met Gly Phe Ile 340 345 350 Asn Leu Ser His His Met Gin Giu Arg 255 360 INFORMATION FOR SEQ ID NO:1863: Wi SEQUENCE CHARACTERISTICS: LENGTH: 662 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY misc -feature LOCATION .662 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1863 dly Asn Thr Ile Ile Lys Met Gin Lys Ser Leu Ile
I
Tyr Tyr Val Asn 20 Ile Ala Asp Thr 35 Phe Phe Leu Thr so Ala Arg Leu Arg 65 Ala Ile Phe Lys Phe Ile Arg Thr 100 Phe Giu Ile Met 115 Gly Tyr Tyr Cys 130 Asp Asn Thr Asp 145 Thr Leu Leu Giu Lys Pro Leo Leu 180 Ile Tyr Arg Lys 195 Asp Leu Se Ile 210 Lys Lys Met Asn 2.25 Leu Leu Asn Tyr Lys Met Ala His 260 5 Asp Leu Gly Asn Asn Thr Phe Val Ser Glu 165 Giu Asn Thr Asp Ala 245 Phe Ile Lys Thr Gin 70 Gin Asp Glu Sen Lys 150 G lu Phe Glu Arg Pro 230 Ser Glu Pro Lys Asp Sen Trp Ser Lys Cys 135 Val1 Ser r Val1 Thr 215 Lys Ala Arg His 40 Glu Pro Asp Glu Gly 120 Glu Leo Ala Thr 200 Ser His Leo Ala Ile 25 Tyr His Lys Phe His 105 Asp Sen Cys Phe
LYS
185 Ser Phe Val1 Gly Arg 265 Gly Thr Gly Ala Phe 90 Gin Ile Tyr Pro Phe 170 Asn Phe G lo Val1 250 His His Leu Gin Asn Lys Tyr Cys Asp Lys Pro Ile Trp Tyr 235 Leu Ile Ala Gin Lys Ala Leu Cys Lys Ala 140 Cys Leu Glu Glu Gly 220 Val1 Asn Val Thr Tyr Gly Ile Asp Asp Val Gly 125 Val Leu Ser Ala Gin 205 Ile Trp Gly Gly Thr Thr Glu Giu Sen Gin 110 Thr Ser Arg Ala Ile 190 Gly Pro Leu Leu Lys 270 Ser Pro Thr Glu Gin Ile Asp Asn Tlyr
LYS
Glu Tyr 175 Leo Leo Leu Asp Asp 255 Asp Leu Leo Arg Phe His Ala. Ile Tyr Trp Pro Ala Phe Leu Met 1390 6 0*00 *0 0 *00* *0*0 0* 6 6* 0 600.
6 6 *6 0 Leu Gly 305 Leu Glu Glu Arg Thr 385 Ile Ala Ala Leu Phe 465 Ala Ala Ser Lys Glu 545 Asp Arg Glu Pro Pro 625 Arg Ala Pro 290 Val Ala Val Arg Leu 370 Lys Leu Leu Lys Glu 450 Leu Phe Lys Lys Ile 530 Lys Phe Ile Asn Glu 610 Ala Asp Gly Leu Lys Met Pro Ile 355 Leu Ile Asp Glu Glu 435 Ala Leu Arg Lys Ile 515 Glu Glu Lys Glu Arg 595 Ser Lys Asn Ser Phe Met Glu Phe 340 Asn Gly Thr Asn Glu 420 Glu Leu Tyr Val Leu 500 Glu Lys Lys Lys Lys 580 Leu Leu Leu Asp Leu 660 Lys Ser Tyr 325 Gly Ala Met Ala Ala 405 Leu Pro Leu Ala Glu 485 Gin Lys Gly Ala Val 565 Ser Arg Val Met Asn 645 Ile Gin Lys 310 Gly Gin Asn Ala Tyr 390 Asn Phe Trp Ser Phe 470 Ile Asp Ile Glu Pro 550 Glu Asn Gin Gly Gly 630 Leu Ser Leu 295 Ser Ile Asp Leu Lys 375 Tyr Ser Asn Val Leu 455 Met Thr Met Glu Glu 535 Pro Ile Lys Ile Gin 615 Glu Ala Leu Glu Gly Asn 360 Lys Pro Phe Ile Leu 440 Ile Pro Pro Val Lys 520 Ala Thr Lys Leu Ile 600 Met Met Leu Gly Glu Asp 345 Asn Tyr Lys Val Tyr 425 His Ala Lys Asn Leu 505 Ile Leu Gin Val Leu 585 Ser Val Ser Ile Asn Leu 330 Phe Asp Phe Glu Pro 410 Asp Lys Asn Ser Asn 490 Gin Glu Ala Glu Gly 570 Arg Gly Cys Glu Ser 650 Val 315 Arg Ser Leu Asn Leu 395 Lys Phe Asn Thr Ala 475 Tyr Asp Lys Glu Asn 555 Leu Leu Ile Val Gly 635 Pro 280 Cys Val His Gly Trp 300 Leu Tyr Lys Gly Tyr 380 Glu Met Leu Asn Leu 460 Met Glu Thr Ile Lys 540 Tyr Ile Lys Ala Val 620 Met Thr 285 Trp Asp Phe Lys Asn 365 Ser Lys Gin Asn Glu 445 Leu Lys Arg Glu Glu 525 Ala Ile Lys Val Leu 605 Ala Ile Arg Thr Ala Leu Ala 350 Leu Leu Ala Leu Lys 430 Ser Gin Leu Phe Pro 510 Lys Glu Ser Glu Asp 590 Asp Asn Leu Glu Ile Gin Leu 335 Leu Leu Lys His His 415 Leu Glu Ser Ala Phe 495 Leu Ile Lys Ile Ala 575 Leu Tyr Leu Ala Lys 655 Glu Lys 320 Arg Val Asn Ser Gin 400 Lys Ile Lys Ser Ser 480 Lys Phe Glu Lys Glu 560 Gin Gly Glu Lys Val 640 Ile INFORMATION FOR SEQ ID NO:1864: SEQUENCE CHARACTERISTICS: LENGTH: 342 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori 1391 (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...342 (xi) SEQUENCE DESCRIPTION: SEQ ID N0:1864 Gly Arg Met Met Lys Ile Val Ile Asp Leu Met Gly Ala Asp His Gly Val Phe Ser Ile Sex Ile Leu Pro Thr 145 Leu Ser Lys Lys Ile Ser Gly Ser 130 Asp Pro Val Glu Met Tyr Ala Arg 115 Val Cys f 4 4 *4 I
IE.
Glu Tyr Ala Ile Val Leu Glu Leu Gly 100 Ile Gly Lys Lys Gly 180 Met Ile Asn Ile Leu 260 SAla Ile SGir Leu Thr Gly Phe 225 Ile Met Thr Ser Ala Ser His Ser 210 Met Gly Gly Asp Val 290 Ile Asn Lys 195 Asp Gly Ser Ala Tyr 275 Ile Tyr Ile Glu C Leu Val C Ala Ser I Glu Ala 70 Gly Met His Ser Lys Gly Lys Arg Pro Glu 150 Ser Val 165 Glu Glu Leu Lys Phe Lys Val Val 230 Phe Lys 245 Met Leu Glu Tyr Ser His i Ala Ile 310 t Phe Glu 325 i Asp Ala 0 ly ;ly Lys 55 Ala Asp Gly Val Pro 135 Tyr Leu Asp Ala Gly 215 Leu Asp Lys Gy Gl 295 Sei Se Val I Asp I 40 Val Thr Ile Ala Glu 120 Ser Leu His Ile Tyr 200 Val Lys Glu SAsn SGly 280 rLys r Ala r Leu Ser 25 Lys Glu Glu Leu Thr 105 Arg Val Ile Tyr Lys 185 Asp Val Thr Ile Ala 265 Ale Sei Va Ly Arg Asp Met Ala Lys 90 Met Pro Leu Asp Asp 170 Gly Phe Asp Thr SLys 250 Phe Pro r Asr L Glu s Sei 33( Ala Leu Lys Ala Ile His Ile Lys 75 Asn Gly Gly Leu Ala Ile Leu Asp 140 Phe Ala 155 Ser Pro Asn Thr Phe Tyr Val Val 220 Glu Gly 235 SSer Ser Gly Ile Leu Leu SAla Arg 300 SSer Gin 315 Glu Thr Thr Arg Ala Ala Cys 125 Ala Leu Lys Leu Gly 205 Val Val Phe Leu Gly 285 Ala Val Asn Pro Gln Lys Asp Thr 110 Thr Gly Met Val Val 190 Asn Cys Ala Lys Lys 270 Val Val Cys Lys Phe Asp Glu Ala Leu Leu Ala Gly Gly 175 Lys Val Asp Ser Ser 255 Gin Asn Glu Leu Ser Ile ryr Ser Leu Arg Met Asn Tyr 160 Leu Glu Glu Gly Ala 240 Lys Lys Lys Cys Arg 320 Ile Thr Gin Ale Ser Asp Gin Gli 341 0 Gin Ser Phe Glu Ser Gin 335 INFORMATION FOR SEQ ID NO:1865: SEQUENCE CHARACTERISTICS: LENGTH: 253 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE.TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori 1392 (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...253 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1865 Asn Ala His Ala Phe Thr His Pro Phe Ser Ala Pro Ala 1 Leu Gly Val Lys Pro Gly Arg Gly Tyr 145 Asp Val Glu Ile Ala 225 Ala Lys Asp His Lys Lys Lys Ala 130 Ala Lys Ser Leu Ile 210 Tyr Gin Ser Thr Leu Glu Phe Ile 115 Phe Ala Ala Ile Glu 195 Glu Gly Lys Gin Ile Lys Tyr Val 100 Ile Thr Arg Thr Tyr 180 Lys Ser His 5 Arg Val Val Glu Leu Ile Trp Gly Tyr Val 165 Val Cys Leu Phe Lys Ser Ile Ala 70 His Gly Asp Lys Val 150 Gin Asn Val Asp Gly 230 Asp Val Ser 55 Val Asp Gly Thr Asp 135 Ala Leu Thr Lys Leu 215 Arg Asn Arg 40 Thr Ile Asn Pro Tyr 120 Pro Lys Ala His Ser 200 Leu Glu Thr 25 Tyr Gin Glu Ile Gin 105 Gly Tyr Asn Tyr Asn 185 Val Arg Leu 10 Leu Glu His Glu Lys 90 Gly Gly Lys Leu Ala 170 Thr Phe Pro Glu Pro Asn Ser Ile 75 Phe Asp Phe Val Val 155 Ile Ser Lys Ile Glu 235 Phe Asn Pro Val Phe Ala Cys Asp 140 Ala Gly Lys Leu Tyr 220 Phe Leu Lys Glu Tyr Ile Gly Pro 125 Met Ser Val His Thr 205 Ser Thr Arg Arg Pro Val Lys Asn Leu 110 His Ser Gly Ile Ser 190 Pro Leu Trp Phe Pro Val Ser Val Pro Thr Gly Ala Val Glu 175 Ser Lys Thr Glu Arg Asp Ser Gin Leu Thr Gly Gly Ala Cys 160 Pro Ala Gly Ser Lys 240 s r r r r Thr Asn Lys Val Glu Glu Ile Lys Ala Phe Phe Lys Arg 245 250 INFORMATION FOR SEQ ID NO:1866: SEQUENCE CHARACTERISTICS: LENGTH: 145 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...145 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1866 Ser Thr Ile His Lys Glu Phe Lys Leu Lys Gin Arg Thr Leu Ser Ile 1 5 10 Ile Lys Pro Asp Ala Leu Lys Lys Lys Val Val Gly Lys Thr Ile Asp 25 1393 Arg The Giu Ser Asn Gly Leu Glu Val Val Ala Met Lys Arg Leu His 40 Leu Ser Val Lys Asp Ala Glu Asn Phe Tyr Ala Ile Leu Arg Glu Arg 55 Pro Phe Phe Lys Asp Leu Ile Glu Phe Met Val Ser Gly Pro Val Val 70 75 Val Met Val Leu Glu Gly Lys Asp Ala Val Ala Lys Asn Arg Glu Leu 90 Met Gly Ala Thr Asp Pro Lys Leu Ala Gln Lys Gly Thr Ile Arg Ala 100 105 110 Asp Phe Ala Giu Ser Ile Asp Ala Asn Ala Val His Gly Ser Asp Ser 115 120 125 Leu Giu Asn Ala His Asn Glu Ile Ala Phe Phe Phe Ala Ala Arg Glu 130 135 140 Phe 145 INFORMATION FOR SEQ ID NO:1867: Wi. SEQUENCE CHARACTERISTICS: LENGTH: 193 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .193 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1867 Gly Arg Gly Gly Ile Tyr Ile Glu His Gly Arg Val Lys Met Val Ala 1 5 10 Leu Ser Asn Ala Leu Ser Arg Val Phe Gly Ser Val Ala Gly Tyr Lys .20 25 Phe Pro Sen Phe Ile Gin Lys Ser Ile Asn Ala Leu Tyr Val Lys Ile 35 40 Phe Lys Ile Asp Leu Sen Glu Phe Giu Pro Leu Glu Asn Tyr Lys Ser so 5 55 Leu Asn Ala Leu Phe Met Arg Sen Leu Lys Lys Glu Ang Pro Phe Asp 70 75 Lys Ala Pro Asn Ile Cys Ile Ala Pro Cys Asp Ala Leu Ile Thr Glu 90 Cys Ala Phe Leu Asp Asn Asp Sen Ala Leu Gin Ile Lys Gly Met Pro 100 105 110 TYr Lys Ala His Glu Leu Val Gly Glu Ile Asn Pro Leu Ser Pro Ser 115 120 125 Phe Phe Tyr Val Asn Phe Tyr Leu Sen Pro Lys Asp Tyr His His Tyr 130 135 140 His Ala Pro Cys Asp Leu Giu Ile Leu Glu Ala Ang Tyr Phe Ala Gly 145 150 155 160 Lys Leu Leu Pro Val Asn Lys Pro Ser Leu His Lys Asn Lys Asn Leu 165 170 175 Phe Val Gly Asn Giu Arg Val Ala Leu Val Ala Lys Asp Asp Ser Ang :180 185 190 Gin 1394 INFORMATION FOR SEQ ID NO:i868: SEQUENCE CHARACTERISTICS: LENGTH: 240 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAIAE/KEY: misc-feature LOCATION 1. 240 (xi) SEQ UEN CE DESCRIPTION: SEQ ID NO:1868 0 0 0009 0 0 0. S Asn Val Ser Ser Ala Tyr Lou Pro Gly Arg 145 Asn Phe Val Val 225 His Asp Val.
Asn so Phe Phe Gly Leu Pho 130 Gly.
Lou, Val Ser Lys.
210 Val Asp Gly le Lou Arg Ala 100 Asn Leu Phe Arg Cys 180 Lou le Phe Ile Arg Lou Ser Phe Pro Val Lou Ser Lou 165 Ile Pro Ile Asp Val Gly Phe Lou Gly Ala 120 Lou Son Lou Gly Tyr 200 Phe Val Asn Lys Gly Ala Giu Ile Sen Asn 25
LYS
Trp Lou Ala Sor 105 Lou Gin Gin Val Lou 185 Glu Pho Leu Leu 10 Pro Gly Ser Ile His 90 Val Gly Asp Lou Ala 170 Phe Gin Val Asp Trp Ang Met Asn Ile 75 Phe Ala Val Met Gly 155 Lou Ala Ile Ser Val 235 Gly Thn Val Phe Lou Val Val Met Giu 140 Giu Ile Lou Asn 220 dly Leu Lys Ile Ile Gly Val Lou Leu 125 Phe Lys Cys Lou Val1 205 Gly Phe Thr Asn Phe Asn Gly Gly Giy 110 Trp Asp Trp Trp Gly 190 Ala Tyr Lys Arg Arg Sen Pro Tyr Leu Asp Val Lys Cys Lou 175 Lou Arg Leu His Leu Pro Val Lou Sen Ala Ile Ala Giu Leu 160 Cys Giy Asp Gly Ala 240 INFORMATION FOR SEQ ID NO:1869: SEQUENCE CHARACTERISTICS: LENGTH: 184 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) (vi) HYPOTHETICAL: YES ORIGINAL SOURCE: 1395 ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...184 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1869 Val Met Ala Ile Trp Gly Trp Cys Phe Leu Phe Leu Ser Ser Leu Met 1 5 10 Trp Gly Ser Ser Met His Glu Leu Val Leu Arg Ser Gin Ala Leu Gly 25 Phe Glu Thr Arg Leu Val Gin Cys Asp Leu Ser Phe Ser Tyr Glu Arg 40 Phe Ile Ser Lys Thr Lys Arg Ser Leu Ala Val Leu Glu Glu Phe Asp 55 Trp Leu Asn Ser Gly Phe Asp Phe Ser Arg Leu Asn Val Glu Asn Asp 70 75 Thr Leu Glu Leu Leu Lys Ala Leu Tyr Phe Lys Leu Glu Lys Leu Glu 90 Ser Leu Leu Leu Lys Glu Asn Leu Leu Glu Leu Glu Gin Lys Asp Arg 100 105 110 Ile Ile Ala Leu Gly His Gly Leu Val Cys Leu Lys Lys Gin Ser Leu 115 120 125 Ile Ala Pro Gin Thr Tyr Tyr Gly Arg Cys Val Leu Glu Gly Lys Ile 130 135 140 Leu Ala Phe Phe Gly Val Ala Arg Asp Lys Asp Phe Leu Glu Ile Thr 145 150 155 160 Arg Met His Ala Leu Asp Ile Lys Arg Tyr Asp Ser Phe Ile Val Asp 165 170 175 Ser Glu Arg Lys Gly Leu Lys Leu 180 S INFORMATION FOR SEQ ID NO:1870: SEQUENCE CHARACTERISTICS: LENGTH: 115 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...115 *o0 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1870 Thr Gly Ala Ile Met Leu Ser Ser Asn Asp Leu Phe Met Val Val Leu 1 5 10 Gly Ala Ile Leu Leu Val Leu Val Cys Leu Val Gly Tyr Leu Tyr Leu 25 Lys Glu Lys Glu Phe Tyr His Lys Met Arg Arg Leu Glu Lys Thr Leu 40 Asp Glu Ser Tyr Gin Glu Asn Tyr Leu Tyr Ser Lys Arg Leu Arg Glu 55 Leu Glu Gly Arg Leu Glu Gly Leu Ser Leu Glu Lys Ser Ala Lys Glu 70 75 Asp Ser Ser Leu Lys Thr Thr Leu Ser His Leu Tyr Asn Gin Leu Gin 1396 90 Glu Ile Gln Lys Ser Met Asp Lys Glu Arg Asp Tyr Leu Glu Glu Lys 100 105 110 Ile Ile Thr 115 INFORMATION FOR SEQ ID NO:1871: SEQUENCE CHARACTERISTICS: LENGTH: 335 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...335 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1871 r rr r r Glu 1 Arg Phe Glu Leu 65 Ala Met Trp Ile Glu 145 Pro Ile Asp Lys Asp 225 Gi1 Thz
GI
Pro Ile Lys S Ser His Glu Phe Thr Lys C Glu Ile Tyr C Glu Leu Gly Thr Gly Val Met Gly Glu 100 Val Pro Leu 115 Lys Thr Tyr 130 Arg Glu Val Asn Asn Ile Phe Gin Ile 180 Pro Gln Gin 195 Ile Lys Phe 210 Phe Glu Glu n Ile Leu Ile r Pro Thr Leu 260 a Asp Val Ser 275 er Asp Lys Glu Ala Phe Asp Ile lu ;ly Glu Gln 85 Asn Glu Leu Tyr Gln 165 Phe Leu Gly Gly Ser 245 Thr Ala Gin Leu Ala Asp 70 Leu Ser Asn Arg Tyr 150 Gly Leu Ala Val Lys 230 Tyr Arg L Asp Gly I Asp Phe 55 Asp Lys Asp Trp Ile 135 Ala Leu Asp Asn Ala 215 Leu Phe Val Ala o Asn 295 Val Asn 40 Leu Pro Gly Asn Leu 120 Tyr Leu Met Arg Leu 200 Lys Asp Val Leu Leu 280 Ser ryr rrp Gln Leu Gin 105 Gly Phe Lys Ser Asp 185 Arg Pro Tyr Arg Ty3 265 Lys 10 His I Ile I Leu I Val Asp 90 Asn Gu Glu Ala Asp 170 His Leu Phe Glu Arg 250 Ser s Arg :le I er I .ys Val I 75 Leu Arg Lys Asp His 155 Met Tyr Arg Val Asn 235 Ser Leu Tyr L jeu ,ys Lys Ile Phe Ile Leu Asp Arg 140 His Arg Phe Val Leu 220 Phe Val Tyr Leu.
Lys Val Met Gin Asl Asn Asn Tyr Ly Gly Tyr Arg Il Val Ala Ile Gl Glu Ser Ile As Arg Asn Tyr Le Tyr Asn Thr Ty 110 Leu Asn Asp Ph 125 Val Lys Glu Gl Arg Asp Asn Ph 16 Glu Tyr Gly Ar 175 Leu His Arg Gl 190 Lys Asp Leu Va 205 Arg Cys Ala A3 His Glu Ile L4 24 Cys Gly Asp S4 255 Arg Gin Leu G: 270 Gly Lys Ser Vi 285 n s e y n u r e y be g ly 1l Gly Gin Met Ala Phe Prc Asp Asp Lys Ile
S
Ala Ala Phe Leu 1397 Val Arg Asn Ala Tyr Ala Ala Asn Gin Val Cys Lys Phe Ile Leu Leu 305 310 315 320 Glu Ile Glu Lys Leu Ala Thr Leu Asn Arg Gin Lys Lys Arg Ile 325 330 335 INFORMATION FOR SEQ ID NO:1872: SEQUENCE CHARACTERISTICS: LENGTH: 94 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...94 (xi) SEQUENCE DESCRIPTION: SEQ ID N0:1872 Phe Tyr Val Ser Ile Ile Lys Cys Thr Pro Leu Leu Val Gin Ile Val 1 5 10 Ile Val Phe Tyr Gly Leu Pro Ala Leu Gly Val Tyr Met Asp Pro Ile 25 Pro Ala Gly Ile Ile Ala Phe Ser Phe Asn Val Gly Ala Tyr Ala Ser 40 Glu Thr Leu Arg Ala Ser Phe Leu Ser Val Pro Lys Asp Gin Trp Asp 55 Ser Ser Leu Ser Leu Gly Leu Asn Tyr Leu Gin Thr Phe Trp His Val 70 75 Ile Phe Phe Gin Ala Leu Lys Val Ala Thr Ala Lys Pro Lys 85 INFORMATION FOR SEQ ID NO:1873: SEQUENCE CHARACTERISTICS: LENGTH: 461 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE- ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...461 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1873 Ser Ile Lys His Leu Gly Lys Lys Glu Val Lys Thr Leu Gly Leu Ser 1 5 10 Ser Leu Gly Gly Thr Leu Glu Phe Tyr Asp Phe Ile Ile Phe Val Phe 25 Phe Thr Ser Ile Ile Ala Lys His Phe Phe Pro Asn Thr Leu Ser Pro 1398 40 Ile Trp Ser Giu Ile Asn Thr Tyr Gly Ile Phe Ala Ala Gly Tyr Leu s0 55 Ala Arg Pro Leu Gly Gly Ile Val Met Ala His Phe Gly Asp Lys Phe 70 75 Gly Arg Lys Asn Met Phe Met Leu Ser Ile Leu Leu Met Val Ile Pro 90 Thr Phe Ala Leu Ala Leu Met Pro Thr Phe Asn Asp Leu Val Gly Phe 100 105 110 Gly Val Asp Ser Met Giy Leu Thr Pro Lys Asn Ala His Tyr Leu Gly 115 120 125 Tyr Ile Ala Pro Vai Phe Leu Val Leu Val Arg Ile Cys Gin Gly Val 130 135 140 Ala Val Gly Gly Giu Leu Pro Gly Ala Trp Val Phe Val His Giu His 145 150 155 160 Ala Pro Gin Gly Gin Lys Asn Thr Tyr Ile Gly Phe Leu Thr Ala Ser 165 170 175 Val Val Ser Gly Ile Leu Leu Gly Ser Leu Val Tyr Ile Gly Ile Tyr 180 185 190 Met Val Phe Asp Lys Pro Val Val Giu Asp Trp Ala Trp Arg Val Ala 195 200 205 Phe Gly Leu Gly Gly Ile Phe Gly Ile Ile Ser Val Tyr Leu Arg Arg 210 215 220 Phe Leu Giu Giu Thr Pro Val Phe Gin Gin Met Lys Gin Asp Asp Ala 225 230 235 240 Leu Vai Lys Phe Pro Lou Lys Glu Val Phe Lys Asn Ser Leu Phe Gly 245 250 255 Ile Ser Ile Ser Met Lou Ile Thr Trp Val Leu Thr Ala Cys Ile Leu 260 265 270 Ile Phe Ile Leu Phe Val Pro Asn Ph. Thr Lou Thr His Pro Asn Phe 275 280 285 His Ph. Thr Pro Phe Glu Lys Thr Tyr Phe Gin Ile. Lou Gly Leu Val 290 295 300 Gly Ile Val Ser Sr Ile Ile Phe Thr Gly Phe Leu Ala Asp Lys Ile *305 310 315 320 Lys Pro His Lys Val Cys Met Ala Phe Ser Ala Ala Phe Gly Phe Phe *325 330 335 Gly Phe Leu Phe Phe Lys Glu Phe Tyr Ser Asn Ala Pro Ser Leu Val 340 345 350 Asn Thr Ile Ile Lou Tyr Phe Leu Ala Cys Phe Cys Ala Gly Ile Met 355 360365 Mn Phe Cys Pro Ile Phe Met Ser Asp Val Phe Ser Ala Arg Ile Arg 370 375 380 Phe Ser Giy Ile Ser Phe Ala Tyr Asn Ile Ala Tyr Ala Ile Thr Ala *385 390 395 400 Gly Phe Thr Pro Gin Leu Ser Ser Trp Leu Asn Ala Lys Ala Ile Ala 405 410 415 Val Pro Glu Ser Leu Gin Ser Tyr Gly Lou Ser Phe Tyr Ile Lou Ile 420 425 430 Val Ser Leu Ile Ala Phe Ile Thr Ser Leu Leu Met Ala Pro Ile Tyr *435 440 445 His Lys Ser Msn Thr GinHis Giu Val Ser Pro Thr Ala 450 455 460 INFORMATION FOR SEQ ID NO:1874: SEQUENCE CHARACTERISTICS: LENGTH: 507 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES 1399 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .507 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1874
*S
S
0* S S Lys 1 Tyr Asp Gly Gly Val Glu Ser Leo Asn 145 His Gly Asp Arg Leu 225 Asn Val Leo Asp Ser 305 Ala Lys Ala Ile C ly 385 Leu Asn Asp Ser Ser Phe Arg Ser Leu Ile Lys 130 Glu Asp Ser Asp Leo 210
LYS
Ala Gly Ala Met 290 Pro Ile Ala Thr Leu 370 Phe Leu Ala Gly Leu Lys Lys 5 Leu Asp Leu Glu Lys Ang Ile Ile Leu Ser Asn Ala Thr Asp Gly Arg Sen Val 100 Vai Asn Val 115 Asn Ile Ala Sen Val Phe Lys Phe Leu 165 Arg Lys Lys 180 Vai Gin Glu 195 Asn Ser Asp Asn Lys Ile Ile Lys Ile 245 Ser Phe Leu 260 Lys Glu Leo 275 Ser Glu Tyr Ser Gly Tyr Lys Lys His 325 His Pro Asn 340 Leu Ser Asp 355 Ile Met Thr Phe Ser Thr Thr Pro Glu 405 Leu Ser Leo 420 Leo Lys Ali% Ala Leo Phe dly 70 Ser Phe Glu Pro Lys 150 Pro Ile Thr Lys Phe 230 Gin Phe Ala Lys Val 310 Pro Val Asn Ser Lys 390 Leui Glu Leu Leu Lys Ile Ser Leo Gbu Gbu Leo 135 Ala Asp Asn Leo Lys 215 Ala His Val1 Leo Glu 295 Gly His Tyr Leo Asn 375 Asn Arg Asp Ala Met Lys 40 Asp Leo Lys Lys Pro 120 Tyr Cys Lys Pro Ala 200 Ala Gin Cys Gly Asn 280 Ala Phe Cys Asp Gly 360 Val Ala Ser Phe Ile Val 25 Thr Glu Asp Cys Asp 105 Sen Glu Val Ala Lys 185 Leo Leo Thr Gly Pro 265 Leo His Glu Leo Leo 345 Asn Gly Lys Arg G bo 425 Glu Ala Leo Ile Ala Leo 90 Lys Lys Glu Asp Ile 170 Lys
LYS
Leu Glu Leo 250 Ser Asn Sen Gin Leo 330 Leu Lys Sen Tyr Ile 410 Arg Gln Gly Lys His Ala 75 Gly Ala Gbu His Leu 155 Glu Gly Leo Arg AlaL 235 Sen Gly Leo Val Gly 315 Leu Leo Ala Lys Asp 395 Asp Ile Gly Ala Glu Thr Asn Ala Phe Ala His 140 Thr Leo Lys Lys Asn 220 Ile Ala Val His Ala 300 Gly Leo Gin Sen Asp 380 Arg Ala Val Val Lys Cys Arg Ser Phe Leo Gin Glu Lys Ile Leo Ile Thr Asn Cys 125 Gin Ser Leo Lys Ile 205 Leo Asn Lys Gly Phe 285 Lys Leo Asp Val1 Phe 365 Lys Ala Ile Ser Ile Tyr Gin Leo Leo Thr Arg 110 Val Asp Ile 190 Pro Glu Leo Asn Lys 270 Glu Leo Leo Glu Met 350 Lys Asp Val1 Val1 Val1 430 Leo Glu Arg Gin Gly Lys Phe Arg Leo Arg Tyr Gbu 175 Ser Lys Lys Val Lys 255 Thr Arg Ile Val Ile 335 Asp His Thr Lys Pro 415 Glu Lys Val Gly Asn Ala Pro Glu Phe Ile Tyr Met 160 Val Val Met Ser Ser 240 Pro Glu Phe Gly An 320 Gbu Asn Val1 Leo Glu 400 Phe Leo Phe 1400 His Phe 465 Gin Ser Lys 450 Giy Leu Leu 435 440 445 Giu Val Val Lys Cys Ile Ala Gin Lys Ser Tyr Gin Arg Ser 455 460 Ala Arg Giu Ile Lys Lys Ile Ile Gin Arg Giu Ile Asn Pro 470 475 480 Ser Asp Ile Vai Leu Lys Gin Ser Leu Lys Lys Pro Thr Arg 485 490 495 Arg Met Lys Ser Thr Phe His Lys Val 500 505 INFORMATION FOR SEQ ID NO:1875: SEQUENCE CHARACTERISTICS: LENGTH: 178 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .178 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i875 4 4*4@ 4* 4. 4 4.
4 4 44 Gly Thr His Glu Asp Thr Lys Gin Met Met 145 Gly Ala Ile Ala Tyr Msn 50 Val Val Phe Gin Phe 130 Sen Phe His Lys Ile Ser 35 Glu Tyr Asn Val 115 Pro Lys Phe Leu Ile Lys Phe Val Arg Phe Leu Ala Phe Met Leu 20 .25 Val Ala Val Ile Ser Gly 40 Msn Thn Pro Msn Msn Lys Phe Val Gin Thn Tyr Asp 70 Arg Asn Giu Msp Thr Arg Sen Ala Asp Ile Ser Ala 100 1l10 Giu Val Gin Tyr Tyr Gly 120 Msn Val Ile Phe Leu Lys 135 Pro Val Phe Sen Tp, Ile 150 Ile Sen Aia-Arg Ser Val 165 Asn Val Val Leu Tyr Lys Thn Gin Pro Ser Msn 125 Glu Phe Cys Ang Leu Lys Phe Leu 110 Leu Ser Leu Pro Asn Arg Val1 Phe Asn Asn Giu Vai 160 Lys Leu Leu Leu Phe Lys Gly 175 INFORMATION FOR SEQ ID NO:1876: SEQUENCE CHARACTERISTICS: LENGTH: 638 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein 1401 (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .638 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1876 Ala Arg Leu Leu Leu Tyr Asn Leu Lys Asn Phe Ile Lys Gly 6 6 6 66 6
V
V*
V
V
1 Ser M Leu A Arg G Leu 1 Ile H Asn C Ile A Lys I Ser 2 145 Thr Glu Phe Ser Thr 225 Val Lys Gin Lys LyS 305 Leu Pro Pro Asn Leu 385 Lys .et .sp lu .0 let [is :ly la ,ys la ;er Ile Leu Val 210 Tyr Lys Met Sez Va] 29C Alz Tyl Se: Le I1 37 Se Va Ser A 2 Leu M Leu I Leu I Leu S Ile G
I
Lys S 115 Lys 2 Phe b His Ser Lys 195 Val Thr Glu Asn Phe 275 Glu x Pro c Val r Tyr u Asn 355 e Arg 0 r Lys 1 Leu sn 0 et le 'hr er ;ly .00 ;er sp let ;in 3lu 180 Glu Lys Asp Glu Lys 26C Ala Gil Ph4
LY
Le 34( Va Se As Ly
S
Gin Giu T Ile His S Sen Asn A 5 Asp Giu I 70 Phe Asp S Met Asp I Gly Thn I Ser Ala I Vai Ala 150 Ala Tyr 165 Cys Val Glu Asp Lys Tyr Thn Lys 230 Lys Cys 245 Sen Glu His Asp r Ser Leu a Asp Leu 310 5 Ang Val 325 Arg Phe 0 1 Ser Arg r Ala Ser p Asn Lys 390 s Glu Gly 405 yr er ,la ,ys er ,ys ,ys .eu L35 Ser kla Lys Ser Ser 215 Phe Asr Let Asr Gil 29 Ph Ph Va Gi' Va 37 As Thr P 2 Leu 40 Ser P Leu I Gin I Ser I Sen I 120 Ile C Lys Trp Glu His 200 Glu Glu Gin 1 Lys I Ser 280 i Tyr a Arg Ile 1 Lys u Ile 360 1 Lys 5 n Tyr 'he 5 'yr 4sp ,ys jys asp L05 ?he ;ly lie Val Glu 185 Phe His Glj I ic Glt 261
GI
Thl Va Th di: 34 Le Ly Hi 10 Gin 'I Ser A Ala L Gly L 7 Lys 1 90 Leu I Leu I Gin I Val Ser 170 Gin Ala Ile Glu Asn 250 1 Lys i Pro c Thr 1 Asp r Asp 330 y Vai 5 u Gin s Ile s Lys y Asp 410 brr *sn 5 eu leu 'hr ile er ?he Jal 3.55 tsp Gly Ser Pro Gly 235 Gin Asp Let Let 311 Asi 114 GI1 Le Ph 39 Ph Glu I Lys C 4 Asp Asn 'I Leu 9 Glu I Ala I Gly 140 Gin Gly Thr Arg Phe 220 Asp Ala STyr 1 Ser Phe 300 Lys Asp a Asp Asn i Sen 380 e Tyr
S
e Glu le A 3 ;lu I
SS
,ys L :hr 1 'hr I is L 1 .eu S 125 lal C rhr I Lys C lu Trp 205 Pro Asn Sen Lys Tyr 285 Tyr Ser Lys Sen Lys 365 Glu Glu Asn sn 0 le eu 'hr :le ,eu ;er ly .ys ly lie .lu Ile Lys Ala Asj 27C Il Iii
GI'
Gl Gi 35 Ii Pr Ly Lys Ser Gin Leu Phe Leu Asn Tyr Pro Ser Lys Asp Gly Thn Gly Asp Phe Tyn Lys Val 160 Lys Phe 175 Thr Leu Ile Asp Phe Leu Lys Glu 240 Leu Trp 255 Phe Tyr i His Asn a Pro Ser e Val Lys 320 Leu Leu 335 Asp Leu 0 e Leu Ala Glu Arg o Phe*Gly 400 *5 Glu Lys 415 Leu Tyr Gi Leu Leu diu Leu Leu Arg Phe Tyr Sen Lys Asp Lys Gly dlu Trp Ile 1402 420 425 430 Ser Lou Lys Glu Tyr Lys Glu Asn Lou Lys Giu Asn Gin Lys Ser Ile 435 440 445 Tyr Tyr Lau Leu Giy Giu Asn Leu Asp Leu Leu Lys Ala Ser Pro Lou 450 455 460 Leu Giu Lys Tyr Ala Gin Lys Gly Tyr Asp Val Lou Lou Leu Ser Asp 465 470 475 480 Giu Ile Asp Ala Phe Val Met Pro Gly Val Asn Giu Tyr Asp Lys Thr 485 490 495 Pro Phe Arg Asp Ala Ser His Ser Glu Ser Lou Lys Giu Lou Giy Lou 500 505 510 Ala Giu Ile His Asp Giu Val Lys Asp Gin Phe Lys Asp Lou Ile Lys 515 520 525 Ala Phe Giu Giu Asn Lou Lys Asp Glu Ile Lys Gly Vol Glu Lou Ser 530 535 540 Gly His Lou Thr Ser Ala Val Ala Lou Ile Gly Asp Giu Pro Asn Ala 545 550 555 560 Met Met Ala Asn Trp, Met Arg Gin Met Gly Gin Ser Val Pro Glu Ser 565 570 575 Lys Lys Thr Lou Giu Lou Asn Pro Asn His Ala Ile Lou Gin Lys Lou 580 585 590 Lou Lys Cys Glu Asp Lys Glu Gin Lou Ser Ala Phe Ile Trp Lou Lou 595 600 605 Tyr Asp Gly Ala Lys Lou Lou Giu Lys Gly Ala Lou Lys Asp Ala Lys 610 615 620 Sor Phe Asn Glu Arg Lou Asn Ser Vol Lou Lou Lys Ala Lou 625 630 635 INFORMATION FOR SEQ ID NO:1877: SEQUENCE CHARACTERISTICS: LENGTH: 425 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori 9 (ix) FEATURE: NAME/KEY: misc-.feature LOCATION .425 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1877 Lys Gin Phe Gly Arg Arg Vol Phe Thr Gin Ile Pro Lys Met Vol Gin 1 5 10 *Phe Gin Asn Thr Lou Ile Lys Phe His Ala Leu Sor Phe Lys Asn Ala 25 Asa Lou Ile Tyr Asn Ala Lys Lou Asn Lys Thr Cys Tyr Lys Giu Asn 40 Ser Asn Thr Ile Ile Lou Arg Ile Lys Met Lou Thr Gin Giu Asp Val Lou Asn Ala Lou Lys Thr Ile Ile Tyr Pro Asn Phe Giu Lys Asp Ile 70 75 Val Ser Phe Gly Phe Vol Lys Asn Ile Thr Lou His Asp Asn Gin Lou -90 Gly Lou Lou Ile Giu Ile Pro Sor Ser Ser Giu Giu Thr Sor Ala Ile 100 105 110 Lau Arg Glu Asn Ile Ser Lys Ala Met Gin Glu Lys Gly Val Lys Ala 115 120 125 1403 Leu Asn 130 Thr Thr 145 Ser Gly Ile Ala Val Tyr Val Ile 210 Gly Val 225 Leu Ile Ser Asp Pro Gly Ser Ala 290 Ala Lys 305 Gly Ile Glu Ser Tyr Asn Leu Gly 370 Val Ser 385 Leu Asp Pro Thr Leu Asp Ile Lys Thr Pro Pro Lys Pro Gin Ala Pro Lys Pro Lys Lys Leu Gly 195 Met Ser Trp Ile Thr 275 Gly Arg Val Glu Thr 355 Gly Ala Lys Gln Asn I Gly Ala 180 Pro Asp Val Arg Ile 260 Gly Ile Ser Glu Ile 340 Gin SAsp Lys SVal SThr 420 .eu ;ly Asn Asn Pro Met Gly 245 Trp Asp Thr Leu Asn 325 Phe Ile Lys Ile Glu 405 His Ala 150 Val Leu Ile Ser Ser 230 Pro Gly Ala Val Asp 310 Met Gly Leu Gly Phe 390 Arg Ala 135 Lys Gly Asn Pro Gly 215 Met Met Asp Gin Thr 295 Met Gly Ser Ala Glu 375 Glu Glu Tyr Asn Lys Gln Arg 200 Lys Gly Leu Leu Leu 280 Thr Phe Ser Asn Lys 360 Pro Lys Lys Ser Ile Ser Lys 185 Met Lys Leu Met Asp 265 Thr Pro Lys Phe Ser 345 Leu Ile Met Leu His 425 Lys rhr 170 Val Met Leu Leu Arg 250 Val Leu Gin Lys Val 330 Met Pro Val Ala Ala 410 His 155 Thr Gly Gly Ile Tyr 235 Ala Leu Ala Ile Leu 315 Cys Ser Leu Ile Lys 395 Asp 140 Val Ser Leu Leu Pro 220 Asp Ile Val Gin Val 300 His Glu Gly Glu Ser 380 Asp Asn Val Val Leu Gin 205 Leu Glu Glu Val Ala 285 Ser Ile His Leu Pro 365 His Leu Lys Met Asn Asp 190 Asn Lys Gly Gln Asp 270 Val Leu Pro Cys Leu 350 Lys Pro Ser Asp Ile Leu 175 Ala Ala Ala Gin Met 255 Met Pro Asp Ile Lys 335 Glu Val Thr Ala Ile 415 Ser 160 Ser Asp Asp Phe Ser 240 Leu Pro Leu Asp Ala 320 Lys Ala Arg Ser Phe 400 Gin INFORMATION FOR SEQ ID NO:18781 SEQUENCE CHARACTERISTICS: LENGTH: 443 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE-: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...443 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1878 Leu Gly Phe Leu Ala Leu His Gly Phe Phe Leu Ser Ala Phe Glu Tyr 1 5 10 Gin Val Ser Ala Arg Val Gly Ser Phe Ser Arg Ile Ala Phe Asn Gin 25 Ser Ile Ile Asn Set Lys Lys Gly Ile Tyr Pro Thr Gly Ser Tyr Val 1404 Thr Thr Thr Gly Ala Leu Ile G Leu A Ala G Tyr I Asn Lys I 145 Phe I Lys Glu Ile Ile 225 Pro Trp Tyr: Ala.
Gly 305 Trp Pro Ile Tyr Val 385 Val Phe Ser lu 1 ia ;ly jeu a Lsp .eu ?he 'ln Asn Tyr Phe Met 115 Arg Ile Ser Lys Tyr 195 o sn 210 k.rg 3iy Arg Leu Ala 290 Trp Asn Tyr Asn Gly 370 Thr Asn Thr Tyr yr Ile Phe Ile Ser 275 Leu Ser Gl Gl Al Ly Ph Gi' Se: Le' 43 His I Asp I Gin I 100 Gin 1 Pro Phe Gly Ile 180 Ile Gly Ala Glu Gin 260 Lys Phe Val Ser 1 Asp 340 i Phe s Leu e Lys if Tyr r Gly 420 u Met 5 .ys I er I ?ro I is S ryr~ ly Phe 165 Val Arg Met Pro Ile 245 Thr Asp Val Tyr Pro 325 Ala Ile Thr Tyr Gin 405 Tyr Ser ~eu hr la 3er lal Ile 3.50 ksn rrp Asp His Phe 230 Thr Thr Tyr Phe Lys 310 Ile Tyr Gl) Tyx Asr 39( Il As Sei Gin Val 2 Gly Phe C Lys Phe I Asn Trp Gin Asn 120 Leu Tyr 135 Lys Leu Gin Gly Phe Ser Phe Tyr 200 Asn Phe 215 Ile Trp His Asp Phe Tyr Tyr Arg 280 Gin Arg 295 Asn Phe Asp Pro Ser Asn Lys Ser 360 Ser Pro 375 Leu Lys Thr Met i Pro Asp r Met Ser 440 sp ;ly .eu Cyr LO1 Lrp ksn 3iy Phe Thr 185 Ala Asn Phe Thr Ala 265 Ala Val Gly Phe Phe 345 lie Ar Ly.
Hir Ph4 42! TTl Ser Ser I Val Gly C 75 Ile Asp C 90 Tyr Met Thr Arg Leu Tyr Arg Tyr 155 Glu Ile 170 Phe Gly Pro Val Leu Val Tyr Pro 235 Lys Ser 250 Trp Phe Ala Leu Asn Phe Asn Ala 315 Tyr Asp 330 Tyr Asn Lys n Ala Asp His Ile 395 i Lys Gly 410 e Ala Gln c Arg Phe jeu ;ly ;lu ;ly ;lu Leu 140 Pro Phe Arg Asn Tyr 220 Lys Tyr Pro Val Arg 300 Ser Thr Ala Leu Ala 380 Tyl Tyl Thl Leu Glu Ala Arg Gin 125 Asp Ser Tyr Ala Tyr 205 Glu Asn Trp Leu Gly 285 Ser Val Lys Asr Let 361 Glr Phe Ly: SIie Pro I Ile Asn Trp 110 Lys Tyr Lys Arg Leu 190 Lys Asn Phe Lys Tyr 270 Lys Tyr Gin Asp Ser 350 1 Val 1 Ser a Met 5 Vai e Gin 430 Lys ly Pro Glu Ala Gin Ala Trp 175 Ala Gin Lys Asn Ser 255 Ser Lys Arg Leu Asp 335 Ile Gin Leu Leu Gly 415 Asn Gly Ala Lys Gly Gin Tyr Leu 160 Lys Asn Lys Tyr Ala 240 Leu Asp Ser Phe Gly 320 Thr Thr Leu Gly Met 400 Phe Arg 0*0*
S.
0 P *0 0 INFORMATION FOR SEQ ID NO:1879: SEQUENCE CHARACTERISTICS: (ii) (iii) (vi) LENGTH: 138 amino acids TYPE: amino acid TOPOLOGY: linear MOLECULE TYPE: protein HYPOTHETICAL: YES ORIGINAL SOURCE: 1405 ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...138 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1879 Tyr Pro Thr Asn Thr Ile Ile Glu Arg Ile Leu Met Phe Lys Lys Met 1 5 10 Cys Leu Ser Leu Leu Met Ile Ser Gly Val Cys Val Gly Ala Lys Asp 25 Leu Asp Phe Lys Leu Asp Tyr Arg Ala Thr Gly Gly Lys Phe Met Gly 40 Lys Met Thr Asp Ser Ser Leu Leu Ser Ile Thr Ser Met Asn Asp Glu 55 Pro Val Val Ile Lys Asn Leu Ile Val Asn Arg Gly Asn Ser Val Glu 70 75 Ala Thr Lys Lys Val Glu Pro Lys Phe Gly Asp Lys Phe Lys Lys Glu 90 Lys Leu Phe Asp His Glu Leu Lys Tyr Ser Gin Gin Ile Phe Tyr Arg 100 105 110 Leu Asp Cys Lys Pro Asn Gin Leu Leu Glu Val Lys Ile Ile Thr Asp 115 120 125 Lys Gly Glu Tyr Tyr His Lys Phe Ser Lys 130 135 INFORMATION FOR SEQ ID NO:1880: SEQUENCE CHARACTERISTICS: LENGTH: 391 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES er.
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature r LOCATION 1...391 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1880 Arg Ile Gly Met Asp Ala Leu Glu Ile Thr Gin Lys Leu Ile Ser Tyr 1 5 10 a Pro Thr Ile Thr Pro Lys Glu Cys Gly Ile Phe Glu Tyr Ile Lys Ser 25 Leu Phe Pro Ala Phe Lys Thr Leu Glu Cys Glu Lys Asn Gly Val Lys 40 V Asn Leu Phe Leu Tyr Arg Ile Phe Asn Pro Leu Lys Lys His Ala Glu 55 Lys Glu His Ala Lys Glu Lys- His Val Lys Glu Asn Val Lys Pro Leu 65 70 75 His Phe Cys Phe Ala Gly His Ile Asp Val Val Pro Pro Gly Asn Asn 90 Trp Gin Ser Asp Pro Phe Lys Pro Ile Ile Lys Glu Gly Phe Leu Tyr 100 105 110 Gly Arg Gly Ala Gln Asp Met Lys Gly Gly Val Gly Ala Phe Leu Ser 115 120 125 Ala Ser Leu Asn Phe Asn Pro Lys Thr Pro Phe Leu Leu Ser Ile Leu 1406 130 135 140 Leu Thr Ser Asp Glu Glu Gy Pro Gly Ile Phe Gly Thr Arg Leo Met 145 ISO 155 160 Leu Giu Lys Leu Lys Glu Lys Asp Leo Leu Pro His Met Ala Ile Val 165 170 175 Ala Glu Pro Thr Cys Giu Lys Val Leu Giy Asp Ser Ile Lys Ile Gly 180 185 190 Arg Arg Gly Ser Ile Asn Gly Lys Leu Ile Leo Lys Gly Val Gin Gly 195. 200 205 His Vai Ala Tyr Pro Gin Lys Cys Gin Asn Pro Ile Asp Thr Leo Ala 210 215 220 Ser Val Leo Pro Le Ile Ser Gly Val His Leo Asp Asn Gly Asp Glu 225 230 235 240 Cys Phe Asp Pro Ser Lys Leo Val Ile Thr Asn Leo His Ala Gly Leo 245 250 255 Gly Ala Asn Asn Val Thr Pro Gly Ser Val Gu Ile Ala Phe Asn Ala 260 265 270 Arg His Ser Leo Lys Thr Thr Gin Giu Ser Leo Lys Glu Tyr Leu Giu 275 280 285 Lys Val Leo Lys Asp Leu Pro Tyr Thr Leo Glu Leo Glu Ser Ser Ser 290 295 300 Ser Pro Phe Ile Thr Ala Ser His Ser Lys Leu Thr Ser Val Leu Gin 305 310 315 320 Glu Asn Ile Leu Lys Thr Cys His Thr Thr Pro Leu Leo Asn Thr Lys 325 330 335 Gly Gly Thr Ser Asp Ala Arg Phe Phe Ser Ala His Gly Ile Glu Val 340 345 350 *Val Glu Phe Gly Ala Ile Asn Asp Arg Ile His Ala Vai Asp Glu Arg 355 360 365 *Val Ser Leu Lys Glu Leo Glu Leo Leo Glu Lys Val Phe Leo Gly Val 370 375 380 *Leo Glu Gly Leo Ser Glu Lys V,385 390 INFORMATION FOR SEQ ID NO:i881: SEQUENCE CHARACTERISTICS: LENGTH: 928 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein 0*.0 (iii) HYPOTHETICAL: YES .0*0 (Vi) ORIGINAL
SOURCE:
o~o ORGANISM: Helicobacter pylori (ix) FEATURE:.
NAME/KEY: misc-feature LOCATION .928 (Xi) SEQUENCE DESCRIPTION: SEQ ID NO:188i Th? Ser Leo Asp His Lys Ile Thr Asp Phe Ser Cys Val Asp Leo Arg 1 5 -10 is Ile Gin Ser Lys Glu Val Sen His Asn Leo Lys Glu Leo Ser Lys Tkir 25 Leo Ile Ser Tyr Pro Phe Glu Lys His Val Glu Ala Leo Gly Glu Gin 40 Cys Sen Asn Phe Val Ser Ile Pro Ile Asn Asn Asp Asp Tyr Ser Asn 55 le Cys Tbx Phe Val Ser Asp Phe Ile Asn Le Ile Ala Ser Tyr Asn 70 75 1407 a a Leu Giu Lys Tyr Tyr 145 ILeu
LYS
LYS
Ile Asn 225 Asp Glu Glu Asn Ser 305 Ser Arg Asn 385 Ile
LYS
Ser Phe Trp 465 Asp
LYS
Ser Asn Phe 545
LYS
Val His Leu Glu Leu Val Leu Ile 115 Gin Cys 130 Lys Pro Ala Lys Pro Gin Ile Phe 195 Lys Asp 210 Phe Lys Giu Ile Ile Giu Tyr Lys 275 Tyr Ile 290 Met Met Giu Ile Ser Leu Leu Phe 355 Lys Giu 370 Cys Arg Asn Asn Giu Tyr Thz Lys 435 Gin Leu 450 Ile Pro Leu Giu Tyr Leu Lys Asp 515 Asp Ile 530 Ala Lys Ile Asp Gin Asp Asn Msn Lys Asp Thr Asn Asn Gin Tyr Asn Gly Lys 155 Giu Leu 170 Lys Lys Lys Phe Giu Lys Giu Ser 235 Asn Lys 250 Cys Asn Asn Ile Asp Val Gin Ile 315 Asn Leu 330 Leu Asp Ile Lys Msn Val Ala Phe 395 Glu Lys 410 Asp Asn Gin Leu Msn Phe Ser Lys 475 Giu Ser 490 Ser Leu Ile Giu Glu Asn Leu Giu 555 Phe Msn 570 Gin Leu Tryr Thr 1408 595 600 605 Leu Glu Val Tyr Asp Cys Arg Lys Ser His Asp His Asn Glu Pro Ile 610 615 620 Ile Leu Ser Gin Gin Ser Thr Gly Phe Gin Trp Ala Phe Asn Phe Met 625 630 635 640 Phe Gly Phe Leu Tyr Asn Val Gly Ser His Phe Ser Phe Asn His Asn 645 650 655 Ile Ile Tyr Val Met Asp Glu Pro Ala Thr His Leu Ser Val Pro Ala 660 665 670 Arg Lys Glu Phe Arg Lys Phe Leu Lys Glu Tyr Ala His Lys Asn His 675 680 685 Val Thr Phe Val Leu Ala Thr His Asp Pro Phe Leu Val Asp Thr Asp 690 695 700 His Leu Asp Glu Ile Arg Ile Val Glu Lys Glu Thr Glu Gly Ser Val 705 710 715 720 Ile Lys Asn His Phe Asn Tyr Pro Leu Asn Asn Ala Ser Lys Asp Ser 725 730 735 Asp Ala Leu Asp Lys Ile Lys Arg Ser Leu Gly Val Gly Gin His Val 740 745 750 Phe His Asn Pro Gin Lys His Arg Ile Ile Phe Val Glu Gly Ile Thr 755 760 765 Asp Tyr Cys Tyr Leu Ser Ala Phe Lys Leu Tyr Leu Arg Tyr Lys Glu 770 775 780 Tyr Lys Asp Asn Pro Ile Pro Phe Thr Phe Leu Pro Ile Ser Gly Leu 785 790 795 800 Lys Asn Asp Ser Asn Asp Met Lys Glu Thr Ile Glu Lys Leu Cys Glu 805 810 815 Leu Asp Asn His Pro Ile Val Leu Thr Asp Asp Asp Arg Lys Cys Val 820 825 830 Phe Asn Gin Gin Ala Thr Ser Glu Arg Phe Lys Arg Ala Asn Glu Glu 835 840 845 S Met His Asp Pro Ile Thr Ile Leu Gin Leu Ser Asp Cys Asp Arg His 850 855 860 Phe Lys Gin Ile Glu Asp Cys Phe Ser Ala Asn Asp Arg Asn Lys Tyr 865 870 875 880 Ala Lys Asn Lys Gin Met Glu Leu Ser Met Ala Phe Lys Thr Arg Leu 885 890 895 S Leu Tyr Gly Gly Glu Asp Ala Ile Glu Lys Gin Thr Lys Arg Asn Phe *900 905 910 Leu Lys Leu Phe Lys Trp Ile Ala Trp Ala Thr Asn Leu Ile Lys Asn 915 920 925 INFORMATION FOR SEQ ID NO:1882: SEQUENCE CHARACTERISTICS: LENGTH: 291 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .291 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1882 Gln Ala Leu Gly Ile Asn Met Cys Ser Lys Lys Ile Arg Asn Leu Ile 1 5 10 1409 Leu Cys Phe Gly Phe Ile Leu Ser Leu Cys Ala Giu Glu Asn Ile Thr 25 Lys Giu Asn Met Tbr Giu Thr Asn Thr Thr Giu Giu Asn Thr Pro Lys 40 Asp Ala Pro Ile Leu Leu Giu Giu Lys Arg Ala Gin Thr Leu Giu Leu 55 Lys Glu Giu Asn Giu Vai Ala Lys Lys Ile Asp Giu Lys Ser Leu Leu 70 75 Glu Giu Ile His Lys Lys Lys Arg Gin Leu Tyr Met Leu Lys Gly Glu 90 Leu His Giu Lys Asn Giu Ser Ile Leu Phe Gin Gin Met Ala Lys Asn 100 105 110 Lys Ser Gly Phe Phe Ile Gly Val Ile Leu Giy Asp Ile Gly Ile Asn 115 120 125 Ala Asn Pro Tyr Giu Lys Phe Giu Leu Leu Ser Asn Ile Gin Ala Ser 130 135 140 Pro Leu Leu Tyr Gly Leu Arg Ser Giy Tyr Gin Lys Tyr Phe Ala Asn 145 150 155 160 Gly Ile Ser Ala Leu Arg Phe Tyr Giy Giu Tyr Leu Gly Giy Ala Met 165 170 175 Lys Gly Phe Lys Ser Asp Ser Leu Ala Ser Tyr Gin Thr Ala Ser Leu 180 185 190 Asn Ile Asp Leu Leu Met Asp Lys Pro Ile Asp Lys Glu Lys Arg Phe 195 200 205 Ala Leu Gly Ile Phe Gly Gly Val Gly Val Gly Trp Asn Gly Met Tyr 210 215 220 Gln Asn Leu Lys Glu Ile Arg Gly Tyr Ser Gin Pro Asn Ala Phe Gly 225 230 235 240 Leu Val Leu Asn Leu Gly Val Ser Met Thr Leu Asn Leu Lys His Arg 245 250 255 Phe Giu Leu Ala Leu Lys Met Pro Pro Leu Lys Giu Thr Ser Gin Thr 260 265 270 Phe Leu Tyr Tyr Phe Lys Ser Thr Asn Ile Tyr Tyr Ile Ser Tyr Asn 275 280 285 Tyr Leu Leu 290 INFORMATION FOR SEQ ID NO:i883: SEQUENCE CHARACTERISTICS: LENGTH: 226 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein :(iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 226 Cxi) SEQUENCE DESCRIPTiON: SEQ ID NO:1883 Arg Phe Phe Arg Lys His Arg Val Ile Ser Met Lys Glu Ile Val Thr 1 S 10 Ile Glu Asn Val Ser Phe Asn Tyr His Asn Arg Ala Ile Phe Lys Asp 25 Phe Asn Leu Ser Ile Gin Glu Gly Asp Phe Leu Cys Val Leu Gly Glu 40 Ser Gly Ser Gly Lys Ser Thr Leu Leu Gly Leu Ile Leu Gly Leu Leu 1410 s0 55 Lys Pro Ser Leu Gly Ser Val Lys Ile Phe Asn Glu Thr Leu Ser Asfl 70 75 Asn Ala Phe Leu Arg Gin Lys Ile Gly Tyr Ile Ala Oin dly Asn Ser 90 Leu Phe Pro His Leu Asn Ala Leu Gin Asn Met Thr Phe Cys Leu Msn 100 105 110 Leo Gin ly Ile Msn Lys Gin Ala Ala Gln Lys Giu Ala Lys Ala Leu 115 120 125 Ala Leu Lys Met Gly Leu Asp Glu Ser Leu Met Asp Lys Phe Pro Asn 130 135 140 Giu Leu Ser Gly Gly Gin Ala Gin Arg Val Gly Ile Ile Arg Gly Ile 145 150 155 160 Ile His Arg Pro Glu Leu Ile Leu Leu Asp Giu Pro Phe Ser Ala Leo 165 170 1'75 Asp Ser Leu Msn Arg Lys Asn Leu Gin Asp Leu Ile Lys Gu Ile His 180 185 190 Gin Msn Ser Cys Ala Thr Phe Ile Met Val Thr His Asp Glu Asn Giu 195 200 205 Ala Gin Lys Leu Ala Thr Lys Thr Leo Gu Ile Lys Ala Leo Lys Gin 210 215 220 Giu Gin 225 INFORMATION FOR SEQ ID NO:1884: i)SEQUENCE CHARACTERISTICS: LENGTH: 594 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE.
NAME/KEY: misc-feature LOCATION l. 594 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1884 Met Ala Asp Leo Leu Sen Ser Leu Lys Msn Leu Ser Ser Sen Ser Gly 1 5 10 Val Tyr Gin Tyr Phe Asp Lys Msn Arg Gin Leu Leu Tyr Ile Gly Lys 25 Ala Lys Msn Leo Lys Lys Arg Ile Lys Ser Tyr Phe Ser Val Arg Msn 40 Msn Giu Ile Thr Pro Asn Pro Arg Thr Ser Leu Arg Val Gin Met Met s0 55 Val Lys Gin Ile Ala Phe Leu Glu Th Ile Leo Vai Glu Mn Giu Gin 70 75 Asp Ala Leu Ile Leu Glu Msn Sen Leu Ile Lys Gin Leu Lys Pro Lys 90 Tyr Msn Ile Leo Leu Arg Aspo-Asp Lys Thr Tyr Pro Tyr Ile Tyr Met 100 105 110 Asp Phe Ser Ile Asp Phe Pro Ile Pro Leo Ile Thr Arg Lys Ile Leu 115 120 125 Lys Gin Pro Giy Val Lys Tyr Phe Gly Pro Phe Thr Sen Gly Ala Lys 130 135 140 Asp Ile Leo Asp Ser Leo Tyr Glu Leo Leu Pro Leo Vai Gin Lys Lys 145 150 155 160 1411 Asn Cys Ile Lys Cys Ile Lys Glu 225 Ala Phe Met Leu His 305 Ala Gin Leu Gin Leu 385 Ser Asn Ser Asp Arg 465 Phe Tyr Thr Leu Lys 545 Gly Ala Arg Asp 165 Cys Cys Leu Ile Cys 245 Gly Lys Asp His Glu 325 Lys Glu Ser Glu Asn 405 Gin Asp Glu Asn Ile 485 Gly Leu Ser Met Val 565 Ala Ile 185 Ile Arg Arg Ala Lys 265 Ser Ala Met Glu Ser 345 Lys Arg Tyr Val Tyr 425 Glu Asn Glu Lys Asp
SOS
Lys Ala Ala Leu Glu 585 Lys Lys Ala Cys Met Phe 170 Thr Lys Glu Asn Leu Ser Ile Ala 235 Lys Leu 250 Ala Val Ala Phe Met Lys Pro Glu 315 Leu Gin 330 Ile Pro Asn Ala Ile Leu Arg Val 395 Gly Gly 410 Arg Arg Leu Leu Leu Trp Ile Leu 475 Glu Lys 490 Ile Ile Arg Leu Ile Asn Leu Leu 555 Asp Tyr 570 Lys Asn Tyr Glu Lys Ser 220 Lys Tyr Leu Glu Gin 300 Gin Glu Lys Gln Glu 380 Glu Met Tyr Thr Val 460 Lys Arg His Gin Phe 540 Lys Phe Ala Gln Glu Asp 205 Asn Ile Asp Val Lys 285 Ala Ile Phe Lys Glu 365 Glu Ile Val His Arg 445 Ile Ser Asp Thr Trp 525 His Glu Gly Val Ile Tyr 190 Arg Leu Gin Leu Lys 270 Ile Ile Leu Ile Gly 350 Ile Ala Phe Val Leu 430 Arg Asp Ser Ser Ile 510 Val Arg Lys Ser Leu 590 Glu 175 Leu Leu Arg Lys Asp 255 Met His Ile Leu Ser 335 Asp Phe Arg Asp Tyr 415 Lys Ala Gly Gly Lys 495 Ser Gin Ser Gly Phe 575 Lys Arg Lys Ile Phe Ile 240 Ile Phe Ser Asn Ser 320 His Lys Ser Ser Thr 400 Glu Gly Leu Gly Ser 480 Ala His Lys Thr Ile 560 Glu Lys INFORMATION FOR SEQ ID NO:i885: i) SEQUENCE CHARACTERISTICS: LENGTH: 424 amino acids TYPE: amino acid TOPOLOGY: linear 1412 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...424 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1885 Arg Lys Asn Met Lys Lys Arg Leu Asn Ile Gly Leu Val Gly Leu Gly 1 5 10 Cys Val Gly Ser Thr Val Ala Lys Ile Leu Gin Glu Asn Gin Glu Ile 25 Ile Lys Asp Arg Ala Gly Val Glu Ile Lys Ile Lys Lys Ala Val Val 40 Arg Asp Val Lys Lys His Lys Gly Tyr Ala Phe Glu Ile Ser Asp Asp 55 Leu Glu Ser Val Ile Glu Asp Lys Gly Ile Asp Ile Val Val Glu Leu 70 75 Met Gly Gly Val Glu Ala Pro Tyr Leu Leu Ala Lys Lys Thr Leu Ala 90 Lys Gin Lys Ala Phe Val Thr Ala Asn Lys Ala Met Leu Ala Tyr His 100 105 110 Arg Tyr Glu Leu Glu Gin Ile Ala Lys Asn Thr Pro Ile Gly Phe Glu 115 120 125 99: Ala Ser Val Cys Gly Gly Ile Pro Ile Ile Lys Ala Leu Lys Asp Gly S130 135 140 Leu Ser Ala Asn His Ile Leu Ser Phe Lys Gly Ile Leu Asn Gly Thr S145 150 155 160 i Ser Asn Tyr Ile Leu Ser Gin Met Phe Lys Asn Gin Ala Ser Phe Lys 165 170 175 Asp Ala Leu Lys Asp Ala Gin His Leu Gly Tyr Ala Glu Leu Asn Pro 180 185 190 Glu Phe Asp Ile Lys Gly Ile Asp Ala Ala His Lys Leu Leu Ile Leu Al S 195 200 205 Ala Ser Leu Ala Tyr Gly Ile Asp Ala Lys Leu Glu Glu Ile Leu Ile 210 215 220 Glu Gly Ile Glu Lys Ile Glu Pro Asp Asp Met Glu Phe Ala Lys Glu S 225 230 235 240 Phe Gly Tyr Ser Ile Lys Leu Leu Gly Ile Aia Lys Lys His Gin Asp 245 250 255 Cys Ile Glu Leu Arg Val His Pro Ser Met Ile Lys Asn Glu Cys Met 260 265 270 Leu Sen Lys Val Asp Gly Val Met Asn Ala Ile Ser Val Ile Gly Asp *275 280 285 Lys Val Gly Glu Thr Leu Tyr Tyr Gly Ala Gly Ala Gly Gly Glu Pro 290 295 300 Thr Ala Ser Ala Val Ile Ser Asp Ile Ile Glu Ile Ala Arg Lys Lys 305 310 315 320 Ser Ser Leu Met Leu Gly Phe Giu Thr Pro Gin Lys Leu Pro Leu Lys 325 330 .335 Pro Lys Glu Glu Ile Gin Cys Ala ?Tyr Tyr Ala Arg Leu Leu Val Ser 340 345 350 Asp Glu Lys Gly Val Phe Ser Gin Ile Ser Ala Ile Leu Ala Gin Asn 355 360 365 Asp Ile Ser Leu Asn Asn Val Leu Gin Lys Glu Ile Pro Gin Ser Asn 370 375 380 Lys Ala Lys Ile Leu Phe Ser Thr His Thr Thr Asn Glu Lys Ser Met 385 390 395 400 Leu Asn Ala Leu Lys Glu Leu Glu Asn Leu Gin Ser Val Leu Asp Thr 405 410 415 1413 Pro Lys Met Ile Arg Leu Glu Asn 420 INFORMATION FOR SEQ ID NO:1886: SEQUENCE CHARACTERISTICS: LENGTH: 326 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .326 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1886 Ser Ang Phe Lys Ang Ala Ile Glu Gin Ala Phe Arg Leu Val Aia Met 1 510 is Ile Asp Cys Ala Ile Ile Gly Gly Giy Pro Ala Gly Leu Sen Ala Giy 25 Leu Tyr Ala Thr Arg Gly Gly Val Lys Asn Ala Vai Leu Phe Giu Lys 40 Gly Met Pro Gly Gly Gin Ile Thn Gly Sen Ser Giu Ile Giu Asn Tyr 55 Pro Gly Val Lys Giu Val Val Ser Gly Leu Asp Phe Met Gin Pro Tnp, 65 70 75 Gin Glu Gin Cys Phe Arg Phe Gly Leu Lys His Glu Met Thr Ala Ile 90 Gin Arg Val Sen Lys Lys Gly Ser His Phe Val Ile Leu Ala Giu Asp 100 105 110 Giy Lys Thr Phe Giu Ala Lys Sen Val Ile Ile Ala Thr Gly Gly Sen 115 120 125 Pro Lys Ang Thr Gly Ile Lys Gly Giu Sen Glu Tyn Trp Gly Lys Gly Val Se h y Ala ThrCy Asp Gli he Ph Ty Lys Asn Lys Giu 145 150 155 160 Val Ala Val Leu Gly Giy Gly Asp Thr Ala Val Glu Glu Ala Ile Tyr 165 170 175 Leu Ala Asn Ile Cys Lys Lys Val Tyr Leu Ile His Ang An-g Asp Gly 180 185 190 Phe Ang Cys Ala Pro Ile Thn Leu Glu His Ala Lys As n Asn Sen Lys 195 200 205 Ile Giu Phe Leu Thr Pro Tyr Val Val Glu Gu, Ile Lys Gly Asp Ala 210 215 220 Sen Gly Val Sen Sen Leu Ser Ile Lys Asn Thr Ala Thr Asn Glu Lys 225 230 235 240 Ang Giu Leu Val Val Pro Gly Leu Phe Ile Phe Val Gly Tyr Asp Val 245 250 255 Asn Asn Ala Vai Leu Lys Glh Giu Asp Asn Sen Met Leu Cys Giu Cys 260 265 270 Asp Glu Tyr Gly Ser Ile Val Val Asp Phe Ser Met Lys T±hr Asn Val 275 280 285 Gin Gly Leu Phe Ala Ala Gly Asp Ile Arg Ile Phe Ala Pro Lys Gin 290 295 300 Vai Val Cys Ala Ala Sen Asp Gly Ala Thr Ala Ala Leu Ser Val Ile 305 310 315 320 Sen Tyr Leu Giu His His 1414 325 INFORMATION FOR SEQ ID NO:1887: SEQUENCE CHARACTERISTICS: LENGTH: 279 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...279 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1887 Lys Leu Trp Glu Phe Ser Leu Arg Val Phe Ile Ile Ser Leu Asn Gln Ala Thr Ser Leu
S
Tyr His Ile Asp 145 His Asn Gly Phe Asp 225 Val Pro Leu His Tyr Leu 130 Phe Leu Gin Val Leu 210 Ala Ile Tyr Lys Ala Ser 115 Glu Leu Leu Glu Gly 195 Lys Thr Ala Ser Trp 275 Lys 100 Leu Asp Glu Tyr Ile 180 Thr His Phe Asp Pro 260 Trp Lys Asn Thr Tyr Ile Phe Trp Asp Lys Asp 165 Gin Gin Ser Ile Asp 245 Lys Gln Phe Ala Phe Phe Ser Met Gln Ile His 150 Ala Glu Gly Arg His 230 Glu Ile Phe Gly Thr Glu Ile Glu Ser Lys Thr 135 Ile Ser Arg Tyr Lys 215 Gly Gin Ala Val 10 Leu Val Phe His His Gn Gly Gly Leu Thr Gin Asn Val Ser Lys 90 Leu Gly Glu 105 Cys Ile Glu 120 Leu Lys Glu Gin Glu Leu Val Lys Ser 170 Val Gly Ile 185 Val Ile Thr 200 Trp Val Val Val Lys Asn Ile Ser Thr 250 Leu Met Arg 265 Arg Asp Ala Gln His Pro Ile Lys 75 Phe Tyr Leu Gly Leu Asn Asp Phe 140 Gly Tyr 155 Glu Pro Ile Lys Pro Lys Pro Val 220 Leu Val 235 Ile Ala Thr Thr Leu Phe Asp Ala Val Lys Lys Met Gly Ile Ala Leu Lys Tyr Ala Ser 110 Ala Ile Cys Glu Gly Leu Arg Leu Met 160 Asn His Glu 175 Tyr Ser His 190 Ala Lys Val Thr Ile Met Gin Pro Phe 240 Lys Glu Glu 255 Phe Lys Phe 270 Glu Leu His INFORMATION FOR SEQ ID NO:1888: SEQUENCE CHARACTERISTICS: LENGTH: 236 amino acids 1415 CE) TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION I1.. .236 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1888 Gly Asp Phe Ile Ile Ser Asn Ile Ser Ile His Pro Lys Thr Met Phe 1 5 10 Lys Asn Ala Leu Asn Ile Gin Asp Phe Ser Phe Lys Asn His Thr Ser 25 Thr Ala Ile Ile Gly Thr Asn Gly Ala Gly Lys Ser Thr Leu Ile Asn 40 Thr Ile Leu Gly Ile Arg Ser Asp Tyr Asn Phe Lys Ala Gin Asn Asn 55 Asn Ile Pro Tyr His Asp Asn Val Ile Pro Gin Arg Lys Gin Leu Gly 70 75 Val Val Ser Asn Leu Phe Asn Tyr Pro Pro Gly Leu Asn Ala Asn Asp 90 Leu Phe Lys Phe Tyr Gin Phe Phe His Lys Asn Cys Thr Leu Asp Leu 100 105 110 Phe Giu Lys Asn Leu Leu Asn Lys Thr Tyr Giu His Leu Sen Asp Gly 115 120 125 Gin Lys Gin Arg Leu Lys Ile Asp Leu Ala Leu Ser His His Pro Gin 130 135 140 Leu Val Ile Met Asp Giu Pro Glu Thr Sen Leu Giu Gin Asn Ala Leu 145 i50 155 160 *le Ang Leu Sen Asn Leu Ile Ser Leu Ang Asn Thn Gin Gin Leu Thr 165 170 175 Ser Ile Ile Ala Thr His Asp Pro Ile Val Leu Asp Sen Cys Giu Tnp Va eoLu180 185 190 ValLeuLeuLeu Lys Asn Gly Asn Ile Ala Gin Tyr Lys Pro Leu An 195 200 205 *Ser Ile Leu Lys Sen Val Ala Lys Thn Phe Asn Phe Lys Giu Lys Pro T210 215 220 TrThn Lys Asp Leo Leu Ala Leu Leu Lys Asp Ile 225 230 235 INFORMATION FOR SEQ ID NO:1889: SEQUENCE CHARACTERISTICS: LENGTH: 113 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KE-Y: misc-featune LOCATION .113 1416 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1889 Ile Tyr Ser His Leu Ala Pro Ile Met His Tyr Gin Leu Thr Ser Phe 1 5 Asn lie Ile Gin Asp Leu Phe Ile Thr Cys His Val Leu Arg Ile Lys 25 30 Met Arg Val Phe Val Cys Phe Leu Gly Val Phe Val Ser Asn Gly Leu 40 45 Ala Arg Phe Gly Tyr Val Val Leu Ile Pro Leu Leu Ile Leu Ser Gly 55 Ser Leu Thr Pro His Gin Ser Phe Gin Leu Gly Ile Ala Val Leu Met 70 7S Gly Tyr Val Phe Gly Ser Phe Leu Ile Gin Phe Leu Ser Pro Leu Met .90 Ser Leu Glu Ser Ile Ala Lys Ile Ser Phe Lys Leu Ile Thr Leu Ser 100 105 110 Phe INFORMATION FOR SEQ ID NO:1890: SEQUENCE
CHARACTERISTICS:
LENGTH: 80 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc feature LOCATION 1...80 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1890 Ser Met Gly Gly Phe Thr Ser Ile Trp His Trp Val Ile Val Leu Leu 1 5 10 is Val Ile Val Leu Leu Phe Gly Ala Lys Lys Ile Pro Glu Leu Ala Lys 25 Gly Leu Gly Ser Gly Ile Lys Asn Phe Lys Lys Ala Val Lys Asp Asp 3S 40 Glu Glu Clu Ala Lys Asn Glu Leu Lys Thr Leu Asp Ala Gin Ala Thr 55 Gin Thr Lys Val His Glu Thr Ser Glu Ile Lys Ser Lys Gn Clu Ser 70 75 INFORMATION FOR SEQ ID NO:1891: SEQUENCE CHARACTERISTICS: LENGTH: 267 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(Vi) ORIGINAL
SOURCE:
1417 ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 267 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1891 Arg Lys Thr Asn His Lys Arg Leu Ile Ser Val Thr Lys
I
Met Thz Leu Tyr Ala lie Leu Ile Asn 145 ieu Glu Met Gin Ile 225 Gly Asn Leu Phe Ile Phe Ala Phe 130 Phe Phe Gin Ser Leu 210 Lys Ala Thr Leu Asn Phe Leu Leu 115 Ile Lys Cys Sen Cys 195 Phe Ala lie Ser Leu Asn Gly Phe 100 Ile Va1 Ala Phe Ile 180 Asn Ile Phe 5 Leu I Ala I Ile Ile Leu Tyr Ala Leu Leu Cys 165 Leu Vai Lys Gin 3er .eu Phe Ile 70 Thr Met Ser Ser Ile 150 Leu Gly Phe Thr Giy 23C Ile Leu I Phe Trp *1 40 Val Phe 55 Gly Leu 1 Gin Ala Leu Ser Arg Leu 120 Phe Tyr 135 Leu Gly Ala Ile Phe Cys Val Pro 200 Ser Ile 215 Ile Asp Giy Ile ,ys Lhr 3er iet Ile Pro 105 Ile Ala Phe Phe Asn 185 Leu Phe Thr Ile 10 Leu Glu Phe Ile Lys Asn Gly Leu 75 Thr Ser 90 Ala Thr Val Val Leu Asn Ile Ser 155 Val Ala 170 Ile Ile Glu Tyr Tyr Tyr Ile Leu 235 Leu Phe Ile Tyr Thr Leu Ser Phe Ile Ile 140 Ile Arg Asn Leu Leu 220 Val Lys Pro Thr Ile Arg Lys Leu 125 Ile Phe Ile Leu Pro 205 Asn Leu Gly Tyr Leu Ser Tyr Leu Ile Leu Met Glu Ile Phe Ile Ser Ser Ser His Asn Gin Ile Thr 110 Tyr Ala Phe Thr Ile Leu Ser Ser Ala 160 Phe Gin Asn 175 Tyr Aia Leu 190 Asn Ile Gly Gln Leu Leu Ala Thr Ser 240 Ser Ala Asn 255 a Thr Phe Phe Ile Ile Gly 245 Leu Leu 250 Arg Met Leu Leu 260 Thr Pro Lys Glu Arg Met Arg 265 INFORMATION FOR SEQ ID NO:1892: SEQUENCE CHARACTERISTICS: LENGTH: 272 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: He-iicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .272 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i892 Arg Lys Gin Giu Met Lys Lys Leu Leu Leu Leu Leu Glu His Lys Ile 141.8 1 5 10 Val Lys Ile Gly Leu Ile Ile Val Ile Vai Leu Val Gly Phe Phe Leu 25 Phe Tyr Giu Gin Giu Ile Lys Giu Lys Ala Val Asn Val Ser Gin Giy 40 Lys Phe Pro Thr Ser Ser Tyr Leu Phe Gin Ala Tyr Glu Gly Ile Lys so 55 Asn Lys Ile Asp Thr Ile Asn Gin Val Lys Pro Asn Asp Giu Thr Lys 70 75 Ser Val Asn Giu Asn Ile Giu Lys Thr Gin Lys Asp Leu Asp Asp Phe 90 Asn Ala Leu Val Gin Lys Leu Pro Asn Leu Pro Lys Asp Phe Asn Lys 100 105 110 Thr Leu Ile Lys Pro Gin Ser Pro Phe Phe Asn Tyr Asn Thr Ala Asn 115 120 125 Giu Asp Giu Lys Asn Arg Leu Val Ile Leu Ala Ser Arg Ile 5cr Ser 130 135 140 Gin Lys Giu Thr Gin Pro Pro Ile Ser Ile Lys Asn Ser Val Ser His 145 ISO 155 160 Ile Lys Ser Lys Glu Lys Arg Giu Leu Giu Lys Giu Trp Ala Lys Pro 165 170 175 Ser Val Ser Phe Giy Ser Phe Ser Leu Leu Ser Ser Ser Ser Ser Phe ISO 185 190 Ser Ser Phe Giu Val Scr Phe Leu Ser Arg Giy Ile Gly Leu Asp Cys 195 200 205 Glu Lys Leu Lys Ser Phe Leu Lys Ala Phe Ser Ser Ser Leu Phe Ser 210 215 220 Leu Leu Ser Ser Leu Phe Cys His Pro Leu Ser Leu Phe Cys 5cr Leu 225 230 235 240 le Gly Leu Ile Phe Cys Phe Ser Lys Phe Ser Arg Giu Leu Val Asn 245 20255 Ala Ser Asn Asn Ser Leu Giu Phe Ser Ser Leu Scr Arg Leu Gly Ser 260 265 270 INFORMATION FOR SEQ ID NO:1893: Wi SEQUENCE CHARACTERISTICS: LENGTH: 338 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY misc-feature LOCATION .338 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1893 Lys Ile Phe Lys Lys Ala Leu Arg His Lys Met Giu Lys Val Cys Val 1 5 10 is Ser Ala Trp Gly Leu Pro Lys- Ile Leu Giu Glu Arg Leu Lys Giu Lys 25 Tyr Gly Asp Asp Trp Glu Lys His Val Lys Ala Lys Ala Ile Asn Giu 40 45 Glu Glu Leu Glu Glu Gin Val Lys Ala Lys Ala Lys Giu Gin Gin Lys so 55 Thr Gin Ang Giu Lys Thr Leu Asn Gly Phe Leu Lys Lys Val Gly Leu 70 75 1419 Lys Lys Arg Asp Met Leu Gin Ser Thr Met Leu Phe Asp Glu Val Lys Giu Phe Ile Thr 145
LYS
Ile Phe Asn 225 Thr Leu Pro Ile Asp 305 His Glu Leu Phe Val Phe Leu Leu Ala Thr 150 Ala Asn 165 Arg Giu Thr Ile Leu Vai Lys Ile 230 Ile Glu 245 Lys Arg Asp Thr Tyr Asp Lys Vai 310 Lys Asp 325 Giu 105 Ala Lys Phe Leu Ser Gin Giu Ile Aia Ile 265 Val Giu Asp Arg Leu Giu Ala Val 170 Ser Ser His Asn Gin 250 Ile Pro Ile Gly Ser 330 Pro His Met INFORMATION FOR SEQ ID NO:1894: 9* SEQUENCE CHARACTERISTICS: LENGTH: 310 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .310 (xi) SEQUENCE DESCRIPTION: SEQ, ID NO:i894 Val Val Val Ile Arg Leu Val-Leu Asn Met Leu Thr Cys Gin Ile Ser I 5 10 Tyr Ile Arg Ile Sen Tyr Leu Val Ser Val Ser Asp Phe Val Ile Cys 20 25 Lys Giu Arg Phe Met Asp Glu Ile Lys Thr Leu Leu Vai Asp Phe Phe 3S 40 Pro Gin Ala Lys His Phe Giy Ile Ile Leu Ile Lys Ala Ile Val Vai 55 Pb. Cys Ile Gly Ph. Tyr Phe Ser Phe Phe Leu Arg Asn Lys Thr Met 1420 Lys Asp Glu Ile Leu Leu Ser Val Thr Phe Ile 100 Thr Leu Gly Val 115 Gly Ile Ala Val 130 Gly Gly Ile Ile 145 Ile Glu Ile Ser Asn Thr Ser Leu 180 Arg Ser Val Ala 195 Arg Arg Ile Glu 210 Leu Val His Lys 225 Asp Lys Asn Met Ser Leu Asn Phe 260 Phe Asn Val Arg 275 Ala Asn Arg Ile 290 Lys Gln Asp Ser 305 Lys Leu Gln Ala Leu Gly 165 Arg Asn Trp Thr Pro 245 Thr Ser Glu Ser i Ile Leu Ile Thr Thr Ser 120 Leu Ala Leu 135 Ile Ile Leu 150 Leu Glu Gly Leu His Asp Ser Asn Ile 200 Val Cys Gly 215 Ile Lys Asp 230 Thr Phe lle Ile Arg Val Glu Leu Ile 280 Ile Pro Phe 295 Lys 310 lie 105 Ile Lys His Lys Gly 185 Ile Val Val Gly Trp 265 Glu 75 Leu Ala 90 Thr Thr Ile Thr Asp Tyr Pro Phe 155 Val Glu 170 Arg Leu Asn Ser Gly Tyr Ile Asp 235 Ile Thr 250 Ala Lys Arg Ile Phe Val Ile Ala 110 Leu Gly 125 Ser Ser Lys Gly Leu Asn Val Leu 190 Asn Thr 205 Ser Asp Met Glu Phe Gly Glu Asp 270 Asn Ala 285 Ala Gin Leu Ser Thr Val Ile Ala Asp Ile 160 Phe Phe 175 Pro Asn Ala Cys Ile Glu Lys Ile 240 Gin Ser 255 Gly Ile Leu Asp Asn Lys Leu Asp Ile 300 Ser Ile Asn S S *r a S. a a a a *S INFORMATION FOR SEQ ID NO:1895: SEQUENCE CHARACTERISTICS: LENGTH: 159 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...159 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1895 Ser Lys Arg Thr Gin Gin Thr Phe Phe Leu Phe Ile Asp 1 5 Asp Tyr Ile Met His Pro Ile Met Phe Ala Tyr Ile Ala Ala Gin Ala Arg Lys Ile Asn Gly Thr Leu Cys Met Ala 35 40 Ile Ser Gin Val Lys Glu Leu Gly Ile Asp Lys Ala Lys 55 Gly Asn Leu Ser Gin Val Ile Ile Tyr Pro Thr Lys Asp 70 Leu Ile Glu Cys Gly Val Pro Leu Ser Asp Ser Glu Ile
I
1421 His Asn Thr Asp Met Arg Ala Arg Gin Val Leu Val Lys Asn Ile Val 100 105 110 Thr Asn Ala Ser Ala Phe Ile Giu Ile Asp Leu Lys Lys Ile Cys Lys 115 120 125 Asn Tyr Phe Ile Phe Leu Ile Ala Met Leu Val Ile Glu Lys Ser Ser 130 135 140 Met Ile Leu Lys Lys Gin Thr Lys Lys Leu Ile Arg Lys Ser Ile 145 150 155 INFORMATION FOR SEQ ID NO:1896: SEQUENCE CHARACTERISTICS: LENGTH: 258 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION 258 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1896 Leu Leu Lys Asn Ile Asp Giu Lys Lys Leu Ser Val Ser Lys Val Asn 1 S 10 Giu Lys Arg His Met Asp Phe Lys Lys Cys Pro Asn Phe Giu Lys Lys 25 Cys Ala Phe Leu Cys Phe Ser Asn Leu Val Leu Leu Ile Glu Ile His 40 Ser Lys Gly Leu His Met Gin Lys Lys Lys Pro Lys Asn Pro Gin Pro 55 Asn Leu Phe Se Ile Leu Asp Lys Gly Asp Val Ala Thr Asn Asn Pro 70 75 Val Glu Giu Sen Asp Lys Ala Asn Lys Ile Gin Giu Pro Leu Pro Tyr 90 Val Val Lys Thr Gin Ile Asn Lys Ala Sen Met Iie-Ser Arg Asp Pro 100 105 110 Sle Giu Trp Ala Lys Tyr Leu Sen Phe Giu Lys Arg Val Tyr Lys Asp 115 120 125 Asn Ser Lys Glu Asp Val Asn Phe Phe Ala Asn Gly Giu Ile Lys Glu 130 135 140 Ser Ser Arg Val Tyr Giu Ala Asn Lys Glu Gly Phe Giu Arg Ang Ile 145 1S0 155 160 Thr Lys Ang Tyr Asp Leu Ile Asp Arg Asn Ile Asp Arg Asn Arg Glu 165 170 175 Phe Phe Ile Lys Giu Ile Giu Ile Leu Thr His Thr Asn Ser Leu Lys 180 185 190 Glu Leu Lys Glu Gin Gly Leu Giu Ile Gin Leu Thr His His Asn Giu 195 200 205 Thr His Lys Lys Ala Leu Giu-Asn Gly Asn Giu Ile Val Lys Giu Tyr 210 215 220 *Asp His Leu Lys Asp Ile Tyr Gin Glu Val Giu Ang Thr Lys Asp Giy 225 230 235 240 Cly Leu Val Arg Gu Ile Ile Pro Ser Ile Ser Ser Ala Giu Tyr Phe 245 250 255 Thr Leu 1422 INFORMATION FOR SEQ ID NO:1897: SEQUENCE CHARACTERISTICS: LENGTH: 20 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...20 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1897 TATACCATGG TGGGCGCTAA INFORMATION FOR SEQ ID NO:1898: SEQUENCE CHARACTERISTICS: LENGTH: 23 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: :o ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...23 (xi) SEQUENCE DESCRIPTION: SEQ ID N0:1898 ATGAATTCGA GTAAGGATTT TTG 23 INFORMATION FOR SEQ ID NO:1899: SEQUENCE CHARACTERISTICS: LENGTH: 22 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO 1423 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...22 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1899 TTAACCATGG TGAAAAGCGA TA 22 INFORMATION FOR SEQ ID NO:1900: SEQUENCE CHARACTERISTICS: LENGTH: 23 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...23 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1900 TAGAATTCGC ATAACGATCA ATC 23 INFORMATION FOR SEQ ID NO:1901: SEQUENCE CHARACTERISTICS: LENGTH: 22 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...22 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1901 ATATCCATCG TGAGTTTGAT GA 22 INFORMATION FOR SEQ ID NO:1902: SEQUENCE CHARACTERISTICS: LENGTH: 25 base pairs 1424 TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...25 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1902 ATGAATTCAA TITTTTATTT TGCCA INFORMATION FOR SEQ ID NO:1903: SEQUENCE CHARACTERISTICS: LENGTH: 21 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...21 e.
(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1903 AATTCCATGG TGGGGGCTAT G 21 INFORMATION FOR SEQ ID NO:1904: SEQUENCE CHARACTERISTICS: LENGTH: 23 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature 1425 LOCATION 1...23 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1904 ATGAATTCTC GATAGCCAAA ATC 23 INFORMATION FOR SEQ ID NO:1905: SEQUENCE CHARACTERISTICS: LENGTH: 25 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...25 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1905 AATTCCATGG TGCATAACTT CCATT INFORMATION FOR SEQ ID NO:1906: SEQUENCE CHARACTERISTICS: LENGTH: 25 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: A) ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...25 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1906 AAGAATTCT TAGCATCCAA ATGGA INFORMATION FOR SEQ ID NO:1907: SEQUENCE CHARACTERISTICS: LENGTH: 24 base pairs o TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genom=ic 1426 (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION .24 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1907 ATTTCCATGG TCATGTCTCA TAITr 24 INFOPRMATION FOR SEQ ID NO:1908: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 23 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISK: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .23 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1908 ATGAATTCCA TCTITTTATTC CAC 23 INFORMATION FOR SEQ ID NO:1909: Wi SEQUENCE CHARACTERISTICS: LENGTH.: 27 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geflomic) .00 (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: CA) ORGANISM: Helicobacter pylori (ix) FEATURE: CA) NAME/KEY: misa-feature CB) LOCATION .27 (xi) SEQUENCE DESCRIPTION: SEQ ID N3:1909 AACCATGGTG A"I'TAAGCA TTGAAAG 1427 INFORMATION FOR SEQ ID NO:1910: SEQUENCE CHARACTERISTICS: LENGTH: 28 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...28 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1910 AAGAATTCCA CTCAAAATTT TTTAACAG 28 INFORMATION FOR SEQ ID NO:1911: SEQUENCE CHARACTERISTICS: LENGTH: 25 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: S(A) ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...25 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1911 GATCATCCAT ATGTTATCTT CTAAT INFORMATION FOR SEQ ID NO:1912: SEQUENCE CHARACTERISTICS: LENGTH: 23 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO 1428 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...23 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1912 TGAATTCAAC CATTTTAACC CTG 23 INFORMATION FOR SEQ ID NO::1913 SEQUENCE CHARACTERISTICS: LENGTH: 27 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc feature LOCATION 1...27 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1913 TATACCATGG TGAAATTTT TCTTTTA 27 INFORMATION FOR SEQ ID NO:1914: SEQUENCE CHARACTERISTICS: LENGTH: 25 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
S (iv) ANTI-SENSE: NO (vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...25 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1914 AGAATTCAAT TGCGTCTTGT AAAAG INFORMATION FOR SEQ ID NO:1915: SEQUENCE
CHARAZTERISTICS:
LENGTH: 24 base pairs 1429 TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...24 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1915 TATACCATGG TGATGGACAA ACTC 24 INFORMATION FOR SEQ ID NO:1916: SEQUENCE CHARACTERISTICS: LENGTH: 23 base pairs TYPE: nucleic acid STRANDEDNESS: double S(D) TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO .3 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...23 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1916' 0 ATGAATTCCC ACTTGGGGCG ATA 23 INFORMATION FOR SEQ ID NO:1917: SEQUENCE CHARACTERISTICS: LENGTH: 25 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO- (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylorl (ix) FEATURE: NAME/KEY: misc_feacure 1430 LOCATION 1...25 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1917 TTATGGATCC AAACCAATTA AAACT INFORMATION FOR SEQ ID NO:1918: SEQUENCE CHARACTERISTICS: LENGTH: 23 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...23 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1918 S TATCTCGAGT TATAGAGAAG GGC 23 INFORMATION FOR SEQ -D NO:1919: SEQUENCE CHARACTERISTICS: LENGTH: 22 base pairs TYPE: nucleic acid o STRANDEDNESS: double S(D) TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori r* e(ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...22 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1919 TTAACCATGG TGAAAAGCGA TA 22 INFORMATION FOR SEQ ID NO:1920: SEQUENCE CHARACTERISTICS: LENGTH: 24 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) 1431 (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...24 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1920 TAGAATTCGC CTCTAAAACT TTAG 24 INFORMATION FOR SEQ ID NO:1921: SEQUENCE CHARACTERISTICS: LENGTH: 22 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCEs ORGANISM: Helicobacter pylori
FEATURE:
NAME/KEY: miscfeature LOCATION 1...22 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1921 TTAACCATGG TGAAAAGCGA TA 22 S(2) INFORMATION FOR SEQ ID NO:1922: SEQUENCE CHARACTERISTICS: LENGTH: 23 base pairs TYPE: nucleic acid S(C) STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...23 (xi) SEQUENCE DESCRIPTION: SEZ :D NO:1922 TAGAATTCOC ATAACGATCA ATC 22 1432 INFORMATION FOR SEQ ID NO:l923: SEQUENCE CHARACTERISTICS: LENGTH: 22 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .22 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1923 ATATCCATGG TGAGTITGAT GA 22 INFORMATION FOR SEQ ID NO:1924: SEQUENCE CHARACTERISTICS: LENGTH: 25 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1924 ATGAATZ'CAA T 1r1'TATI'T TGCCA INFORMATION FOR SEQ ID NO:1925: Wi SEQUENCE CHARACTERISTICS: LENGTH: 23 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI 1-SENSE: NO 1433 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .23 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:l925 AAT1'CCATGG CTATCCAAAT CCG 23 INFORMATION FOR SEQ ID NO:1926: SEQUENCE CHAR.ACTERISTICS: LENGTH: 25 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: fl NAME/KEY: misc-feature LOCATION (xi) SEQUENCE DESCRIPT'ION: SEQ ID NO:1926 ATGAATTCGC CAAAATCGTA GTATT INFORMATION FOR SEQ ID NO:1927: Wi SEQUENCE CHARACTERISTICS: LENGTH: 24 base pairs TYPE: nucleic acid STRANDEDNESS; double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature CB) LOCATION 1 .24 (xi) SEQUENCE DESCRIPTION: SEQ: 7-0 NO:1927 GATACCATGG AAT'IATGAA AAAG 2 4 INFORMATION FOR SEQ ID NO:1928: SEQUENCE CHARACERISTICS: LEI=Tl: 25 base par 1434 TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE; NO (vi) ORIGINAL SOURCE: CA) ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY misc_feature LOCATION 1. (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1928 TAATTCGAA AAAGTGTAGT TATAC INFORMATION FOR SEQ ID NO::1929 SEQUENCE CHARACTERISTICS: LENGTH. 19 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) *(iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacier pylori (ix) FEATURE: NAME/KEY: misc-feature OV. LOCATION .19 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1929 CCCTTCAT TAGAAATCG 19 INFORMATION FOR SEQ ID NO:1930: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 20 base pairs CB) TYPE: nucleic acid CC) STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) Ciii) HYPOTHETICAL: NO (iv) ANTI7-SENSE: NO (vi) ORIGINAL SOURCE: CA) ORGANISM: Helicobacter pylor±4 (ix) FEATURE: (A NAME/KEY: misc-.feature 1435 LOCATION 1...20 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1930 ATTTCAACCA ATTCAATGCG INFORMATION FOR SEQ ID NO:1931: SEQUENCE CHARACTERISTICS: LENGTH: 20 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc feature LOCATION 1...20 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1931 GCCCCTTTTG ATTTGAAGCT INFORMATION FOR SEQ ID NO:1932: SEQUENCE CHARACTERISTICS: LENGTH: 22 base pairs TYPE: nucleic acid STRANDEDNESS: double S(D) TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) g (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: S(A) ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...22 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1932 TCGCTCCAAG ATACCAAGAA GT 22 INFORMATION FOR SEQ ID NO::1933 SEQUENCE CHARACTERISTICS: LENGTH: 22 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) 1436 (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/Krf: misc-feature LOCATION .22 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1933 CTTGAATTAG CGGCAAAGAT CG 22 INFORMATION FOR SEQ ID NO:1934: SEQUENCE CHARACTERISTICS: LENGTH: 22 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .22 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1934 ATGCGTI'17r ACCCAAAGAA CT 22 INFORMATION FOR SEQ ID NO:193S: SEQUENCE CHARACTERISTICS: LENGTH: 22 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANT-I-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FZATURE: NAME/KEY: -misc-feature LOCATION .22 (xi) SEQUENCE DESCRIPTION: SEQ 1D NO:1935 ATAACGCCAC 7r=TAI'G CTZ 1437 INFORMATION FOR SEQ ID NO:1936: SEQUENCE CHARACTERISTICS: LENGTH: 19 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: NO (Vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .19 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1936 CT1'IGGTAA AAACGCATC 19 INFORMATION FOR SEQ ID NO:1937: SEQUENCE CHARACTERISTICS: LENGTH: 20 base pairs TYPE: nucleic acid CC) STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genozuic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: CA) NAME/KEY: misc-feature LOCATION I1.. (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1937 CGATCTI'GA TCCTAATTCA INFORMATION FOR SEQ ID NO:1938: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 19 base pairs TYPE: nucleic acid CC) ETRANDEDNESS: double CD) TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) Ciii) HYPOTHETICAL: NO (1v) AJ-S-ENSE. NO 1438 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .19 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1938 ATCAAGTIGC CTATGCTGA 19 INFORMATION FOR SEQ ID NO:1939: Mi SEQUENCE CHARACTERISTICS: LENGTH: 22 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: 00.0 NAME/Krf: misc-feature LOCATION .22 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1939 TTGAACACTT TTGATI'ATOC GG 22 INFORMATION FOR SEQ ID NO:1940: SEQUENCE CHARACTERISTICS: LENGTH: 23 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc..feature LOCATION 23 (xi) SEQUENCE DESCRIPTION: SE2 1D NO:1940 GGATTATGCG ATrTTTTAC AAGQ 23 INFORM4ATION FOR SEQ ID NO:1941: SEQUENCE CHARACTERISTICS: LENGTH: :1 base pairs 1439 TYPE: nuclelc acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...21 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1941 GTCTTTAGCA AAAATGGCGT C 21 INFORMATION FOR SEQ ID NO:1942: SEQUENCE CHARACTERISTICS: LENGTH: 21 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular o* (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO t (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...21 (xi) SEQUENCE DESCRIPTION: SEQ ID N0:1942 AATGAGCGTA AGAGAGCCTT C 21 INFORMATION FOR SEQ ID NO:1943: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature 1440 LOCATION IS8 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:194 3 cT1'ATGGGGG TATI"GTCA 18 INFORMATION FOR SEQ ID NO:1944: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .18 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1944 ,ges, AGCATGTGGG TATCCAGC 1 0 INFORMATION FOR SEQ ID NO:1945: 600 00:0 Ci) SEQUENCE CHARACTERISTICS: LENGTH: 19 base pairs TYPE: nucleic acid :e STRANDEDNESS: double CD) TOPOLOGY: circular (ii) MOLECULE TYPE: DNA Cgenomic) toa (iii) HYPOTHETICAL: NO 00 (iv) ANTI-SENSE: No Cvi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori 0*60**Cix) FEATURE: NAME/KEY: misc-feature LOCATION .19 SEQUENCZ DESCRIPTION: SEQ ID NO:1945 AGG2'rGTTcC CTAAAGACT 19 INFORMATION FOR SEQ ID NO:1946: Ci) SEQUENCE CHARACTERISTICS: CA) LENGTH: 18 tase pairs TYPE: nucleic acid STRANDEDNESS: double CD) TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) 1441 (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-.feature LOCATION .18 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1946 CTGCCTCCAC CTrI'GATC 18 INFORM4ATION FOR SEQ ID NO:1947: SEQUENCE CHARACTERISTICS: LENGTH: 19 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .19 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1947 9. ACCAATATCA ATIGGCACT 19 INFORMATION FOR SEQ ID NO:1948: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: double CD) TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .18 (xi) SEQUENCE DESCRIPTION: SEEZ :D NO:1948 ACTTGGAAAA GCTCTGCA 1 1442 INFORMATION FOR SEQ ID NO:1949: SEQUENCE CHARACTERISTICS: LENGTH: 19 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...19 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1949 CTTGCTTGTC ATATCTAGC 19 INFORMATION FOR SEQ ID NO:1950: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...18 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1950 4 GTTGAAGTGT TGGTGCTA 18 INFORMATION FOR SEQ ID NO:1951: SEQUENCE CHARACTERISTICS: LENGTH: 22 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) AITI-3ENSE: NO 1443 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...22 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1951 CAAGCAAGTG GTTTGGTTTT AG 22 INFORMATION FOR SEQ ID NO:1952: SEQUENCE CHARACTERISTICS: LENGTH: 22 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...22 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1952 TGGAAAGAGC AAATCATTGA AG 22 INFORMATION FOR SEQ ID NO:1953: SEQUENCE CHARACTERISTICS: LENGTH: 21 base pairs S* TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...21 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1953 GCCCATAATC AAAAAGCCCA T 21 INFORMATION FOR SEQ ID NO:1954: SEQUENCE CHARACTERISTICS: LENGTH: 24 base pairs 1444 TYPE: nuclelL acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...24 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1954 CTAAAACCAA ACCACTTGCT TGTC 24 INFORMATION FOR SEQ ID NO:1955: SEQUENCE CHARACTERISTICS: LENGTH: 16 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...16 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1955 GTAAAACGAC GGCCAG INFORMATION FOR SEQ ID NO:1956: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature 1445 LOCATION .17 (Xi) SEQUENCE DESCRIPTION: SEQ ID NO:1956 CAGGAAACAG CTATGAC 17

Claims (12)

1. A drug screening assay comprising the step of contacting a test compound with a purified polypeptide comprising an amino acid sequence that is at least homologous to an amino acid sequence shown in the sequence listing.
2. The assay of claim 1, comprising determining if the compound binds to said amino acid sequence of the purified polypeptide.
3. The assay of claim 1 or 2, comprising determining if the test compound alters the binding affinity of said amino acid sequence of the purified polypeptide for a ligand thereof.
4. The assay of claim 3, wherein the ability of the test compound to inhibit the binding ability of said amino acid sequence to the ligand is determined.
The assay of claim 1 or 2, wherein the polypeptide has enzymatic activity, and the assay comprises detecting if the test compound changes the enzymatic activity.
6. The assay of claim 5, wherein the enzymatic activity produces a detectable reaction Sproduct with distinctive absorption, fluorescence or chemi-luminescence properties.
7. The assay of any one of any preceding claim, wherein the assay is a cell-free assay. 25
8. The assay of any preceding claim, wherein the amino acid sequernce comprised by the purified polypeptide is at least 70%, 80%, 90%, 95%, 98% or 99% homologous to an amino acid sequence shown in the sequence listing, or identical to an amino acid sequence shown in the sequence listing. 30
9. A drug screening assay comprising the step of contacting a test compound with an isolated nucleic acid comprising a nucleotide sequence that is at least 60% homologous to a nucleotide sequence shown in the sequence listing. The assay of claim 9, comprising determining if the compound binds to, or interacts with, said nucleotide sequence of the nucleic acid.
I 1447
11.The assay of claim 9, wherein the assay is an in vitro assay.
12.The assay of any one of claims 9 to 11, wherein the nucleotide sequence comprised by the nucleic acid is at least 70%, 80%, 90%, 95%, 98% or 99% homologous to a nucleotide sequence shown in the sequence listing, or identical to a nucleotide sequence shown in the sequence listing. DATED this 5th day of 1999 July ASTRA AKTIEBOLAG, By its Patent Attorneys, E. F. WELLINGTON CO., By: a V si i i l"~lh (Bruce Wellington) o r f ft e @a
AU37960/99A 1995-06-07 1999-07-05 Assays using nucleic acid and amino acid sequences relating to helicobacter pylori Abandoned AU3796099A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU37960/99A AU3796099A (en) 1995-06-07 1999-07-05 Assays using nucleic acid and amino acid sequences relating to helicobacter pylori

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/487032 1995-06-07
US08/630405 1996-04-01
AU63278/96A AU710880C (en) 1995-06-07 1996-06-06 Nucleic acid and amino acid sequences relating to helicobacter pylori for diagnostics and therapeutics
AU37960/99A AU3796099A (en) 1995-06-07 1999-07-05 Assays using nucleic acid and amino acid sequences relating to helicobacter pylori

Related Parent Applications (1)

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AU63278/96A Division AU710880C (en) 1995-06-07 1996-06-06 Nucleic acid and amino acid sequences relating to helicobacter pylori for diagnostics and therapeutics

Publications (1)

Publication Number Publication Date
AU3796099A true AU3796099A (en) 1999-08-26

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AU37960/99A Abandoned AU3796099A (en) 1995-06-07 1999-07-05 Assays using nucleic acid and amino acid sequences relating to helicobacter pylori

Country Status (1)

Country Link
AU (1) AU3796099A (en)

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