WO1997016579A1 - Materiau metallique en contact avec un corps vivant - Google Patents

Materiau metallique en contact avec un corps vivant Download PDF

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Publication number
WO1997016579A1
WO1997016579A1 PCT/JP1996/003175 JP9603175W WO9716579A1 WO 1997016579 A1 WO1997016579 A1 WO 1997016579A1 JP 9603175 W JP9603175 W JP 9603175W WO 9716579 A1 WO9716579 A1 WO 9716579A1
Authority
WO
WIPO (PCT)
Prior art keywords
alloy
metal member
metal
living body
noble metal
Prior art date
Application number
PCT/JP1996/003175
Other languages
English (en)
Japanese (ja)
Inventor
Sekio Fukuyo
Original Assignee
Sekio Fukuyo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sekio Fukuyo filed Critical Sekio Fukuyo
Publication of WO1997016579A1 publication Critical patent/WO1997016579A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C5/00—Alloys based on noble metals
    • C22C5/02—Alloys based on gold
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A61L27/06—Titanium or titanium alloys
    • C—CHEMISTRY; METALLURGY
    • C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
    • C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
    • C23C8/00—Solid state diffusion of only non-metal elements into metallic material surfaces; Chemical surface treatment of metallic material by reaction of the surface with a reactive gas, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals
    • C23C8/06—Solid state diffusion of only non-metal elements into metallic material surfaces; Chemical surface treatment of metallic material by reaction of the surface with a reactive gas, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals using gases
    • C23C8/08—Solid state diffusion of only non-metal elements into metallic material surfaces; Chemical surface treatment of metallic material by reaction of the surface with a reactive gas, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals using gases only one element being applied
    • C23C8/10—Oxidising
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00011—Metals or alloys
    • A61F2310/00023—Titanium or titanium-based alloys, e.g. Ti-Ni alloys

Definitions

  • the present invention relates to a biocontact metal member made of an alloy containing a noble metal as a main component.
  • alloys containing precious metals as main components for example, gold alloys such as Au-Ag-Cu alloys and Au-Pd-Ag alloys, have been used as materials for metal parts for medical and decorative purposes. It has been heavily used. For example, attention has been paid to the excellent formability and stability in the oral cavity of such gold alloys and the like, and medical metal members used for dental treatment such as inlays, crowns, bridge dentures, etc. It is widely used as a material to be given, or as a material for manufacturing metal members for decoration such as earrings, rings, necklaces, bracelets, watch bands, etc. by using gold or gold alloy or its excellent decorativeness. It is being done.
  • such a biocontact metal member is Since it is composed of a gold alloy, it is not only excellent in formability but also excellent in stability, and is used by being embedded in biological tissue such as bone. Although it has suitable properties as an imprint material, it is not actually applied at all, and as described above, the gold contained in such a metal member is ionized and eluted. There is a great reason for being swayed.
  • the characteristics of the noble metal such as gold contained in the metal member are utilized and used for various purposes.
  • the noble metal such as gold contained in the metal member.
  • it since it is ionized and eluted in the living body, there is a serious problem that a metal allergy is generated in the wearer, and that it cannot be used practically as an imprint material. Disclosure of the invention
  • the present invention has been made in view of the above-mentioned circumstances, and a solution of the present invention is to provide a medical metal member or decoration made of an alloy containing a precious metal such as gold as a main component.
  • a solution of the present invention is to provide a medical metal member or decoration made of an alloy containing a precious metal such as gold as a main component.
  • metal members for biological contact such as metal members and the like, the elution of metal ions such as gold ions from such metal members can be prevented in a favorable manner.
  • the present invention has been completed based on such findings, and is characterized by an alloy containing a noble metal as a main component, which is attached to a living body and brought into contact with a living tissue.
  • Ti is contained as an alloy component for the noble metal, and an oxide film layer of Ti is formed on the surface of the member by heat treatment.
  • the entire surface is covered with a Ti oxide film layer having a property capable of inhibiting elution of noble metal ions such as gold ions. It is being done.
  • the noble metal such as gold in the metal member can be effectively prevented from being ionized and eluted. It is possible to effectively prevent the occurrence of gold energies, and metal parts made of alloys containing precious metals as main components are extremely advantageous as imprint materials, which were previously inapplicable. It can be applied, and the imprint material is advantageously imparted with excellent compatibility with biological tissue such as bone, which is a conventionally known property of the oxide film layer of Ti. You can be squeezed. Therefore, by using the metal member for living body contact according to the present invention, it is possible to effectively prevent contact inflammation or the like from occurring on the mucous membrane or skin of the wearer due to a metal allergy due to a noble metal such as gold. In addition, an imprint material having good moldability, better biocompatibility, and even better compatibility with living tissue can be realized very advantageously.
  • a medical metal member made of an alloy containing a noble metal as a main component, which is attached to a living body and brought into contact with a living tissue, is provided.
  • Ti is contained as an alloy component for the noble gold alloy, and an oxide film layer of Ti is formed on the surface of the member by heat treatment.
  • the medical metal member is configured as an implant for a living body.
  • a bioimplant material that is more excellent in moldability and biocompatibility and more excellent in compatibility with living tissue can be advantageously realized.
  • the implant material for a living body is configured as a dental intraosseous implant, whereby the moldability and the biological properties are improved.
  • a dental intraosseous implant that is not only excellent in affinity but also excellent in compatibility with alveolar bone can be advantageously realized, so that dentures and the like attached to the implant can be more stable in the oral cavity It can be fixed.
  • a decorative metal member which is attached to a living body and is brought into contact with a biological tissue and which is made of an alloy containing a noble metal as a main component, contains Ti as an alloy component for the noble metal.
  • a Ti oxide layer is formed on the surface of the member by heat treatment.
  • the noble metal such as gold in the metal member can be ionized and eluted by the oxide film layer of Ti and being formed on the surface. Therefore, it is possible to effectively prevent the occurrence of metal allergy due to the noble metal in the wearer, and to cause contact inflammation or the like on the mucous membrane or skin of the wearer.
  • the decorative metal member is constituted by any one of a pierced earring, a ring, a necklace, a bracelet, and a watch band. That is to say, by wearing these ornaments, it is possible to effectively eliminate the possibility of producing metal allergies.
  • the alloy providing those metal members may be an Au—Ti alloy, an Au—Ag—C It is composed of u—Ti alloy or Au—Pd—Ag—Ti alloy so that each metal member for biological contact, medical use, and decoration can be used. It can be advantageously applied to conventional metal members made of an alloy such as, for example, metal members frequently used in ornaments and dental treatments. Characteristics can be very effectively demonstrated.
  • the metal member for living body contact is contained in a proportion not exceeding 10% by weight of Ti.
  • the precious metal and Ti can be favorably and reliably alloyed without deteriorating the physical properties of the precious metal, which is the main component of the metal member for biological contact, so that the medical metal member ⁇ the decorative metal member and the like can be obtained. Therefore, it can be used very advantageously.
  • the biocontact metal member according to the present invention contains a noble metal as a main component and a Ti force ⁇ as an alloy component for the metal member, as described above.
  • the type of such a noble metal is not particularly limited, and may be, for example, Au, Ag, Pd, Pt, etc., which are usually included in metal members for medical use, decoration, etc. One type may be used alone, or two or more types may be used in combination. Au is preferably used as the noble metal.
  • alloy components generally contained in metal members for medical use, decoration, etc., such as Cu and other trace components are contained.
  • an alloy providing a biological contacting gold ⁇ material according to the present invention, as long as it is a noble metal and T i comprising been made to contain a composition of, the invention is not particularly limited
  • Various alloy compositions such as Ti, Au-Pt-Pd-Ag-Cu-Ti can be employed.
  • the composition ratio of each of the alloy components is not limited at all, and a general composition ratio can be appropriately adopted.
  • Ti is not limited to any alloy composition. It is preferable that the content is not more than 10% by weight. However, if the Ti content exceeds 10% by weight, the Ti will be excessively contained in the precious metal, which is the main component, and as a result, the precious metal will be alloyed with the Ti. Not only becomes difficult, but also due to the presence of large amounts of Ti in the alloy Therefore, the physical properties of the noble metal are impaired.
  • the content ratio of Ti is desirably preferably 5% by weight or less, particularly preferably 2% by weight or less. As described above, when the content ratio of Ti is set to 2% by weight or less, the color of the surface of the biocontact metal member can be effectively maintained at the color of the noble metal, and the metal member member ⁇ It can be used more effectively for decoration.
  • an oxide film layer of Ti is formed on the surface of the metal member by an appropriate heat treatment.
  • the heat treatment method for forming such an Ti oxide film layer is not particularly limited. That is, when heat treatment is performed on such a metal member, a one-piece heat treatment apparatus can be used, and the heat treatment temperature is determined by the melting point (melting point) of each alloy component. The heat treatment time is appropriately determined in consideration of such factors, and the appropriate heat treatment time is determined in accordance with the determined heat treatment temperature and the like. When the heat treatment is performed at a relatively high temperature for a short time, the color of the surface of the obtained metal member can be advantageously maintained at the color of the noble metal.
  • the thickness of the oxide layer of Ti formed on the surface of the biocontact metal member by the heat treatment is not limited at all, but is set to about 10 m at a time. .
  • the Ti oxide film layer formed in this manner has features that cannot be seen in other metal oxide films, such as being able to prevent elution of precious metal ions, as described above. Accordingly, in the metal member for biological contact having such an oxide film layer of T i formed on the surface, the ionization and elution of the noble metal in the metal member can be effectively prevented. It is. As a result, in such a metal member for living body contact, a metal allergy may occur in a wearer of the metal member.
  • An imprint material that can be effectively prevented has excellent moldability and biocompatibility, which are inherent properties of the metal, and also has convenient compatibility with biomaterials having an oxide layer of Ti. Can be used very advantageously.
  • a metal member for living body contact having such extremely excellent characteristics is attached to a living body, and is made of a metal member to be brought into contact with living tissue, for example, embedded in alveolar bone, and a denture or the like is placed in the alveolar bone.
  • alloys that use precious metals as the main component such as oral implants (dental endosseous implants) that are fixed to bones and bolts that are embedded in fractured bones to connect such bones, are not applicable.
  • a medical metal member such as a metal member for general dental treatment, such as a bioimplant material, an inlay, a crown, and a bridge denture, which has been made possible, and a pierced earring, a ring, a necklace, and a bracelet. It can be used very advantageously as a decorative metal member such as a watch band or a watch band.
  • Such a biocontact metal member according to the present invention is advantageously manufactured as follows.
  • T i and, if necessary, other alloy components are dissolved in a noble metal by a conventional method, for example, an arc melting method, to obtain a melt (molten metal).
  • a conventional method for example, an arc melting method
  • the dissolving operation needs to be performed in an inert gas atmosphere such as Ar gas.
  • the melt obtained in this manner is manufactured to obtain an ingot, and thereafter, the ingot is subjected to general plastic working, forming, or the like, for example, press forming to obtain a predetermined shape. Is obtained.
  • the surface thereof is polished by a known method, and then subjected to a general heat treatment in the air, so that the surface of the alloy member is Form an oxide layer of Ti for the purpose Is obtained.
  • the biocontact metal member configured according to the present invention may be an alloy member having a predetermined shape by using a general alloy molding and manufacturing method such as powder metallurgy, in addition to the above-described manufacturing method. It can also be manufactured by manufacturing the alloy member and then heat-treating the alloy member. Even when such a method is adopted, the method of heat treatment of the alloy member is not particularly limited, as in the above-described production method.
  • a general alloy molding and manufacturing method such as powder metallurgy
  • Au is used as a noble metal, and this Au is included as a main component, and at the same time, Ti or Ti and Ag are included as alloy components with respect to the Au, and these metals are used.
  • Each of Au, Ti, and Ag was separately charged into a predetermined crucible so as to obtain six kinds of alloys having the composition ratios shown in Table 1 below.
  • r Dissolution was performed by performing arc melting according to a conventional method in an atmosphere to obtain six types of melts (melts) having different component compositions from each other.
  • an alloy containing Au as a main component and containing Ti as an alloy component with respect to the Au has a low Ti content. Specifically, when the content of Ti is about 2% by weight or less, there is no remarkable decrease in physical properties even when compared with pure gold, and thus the physical properties of Au are effective. It is confirmed that the power has been secured.
  • the surface of each alloy was polished according to a conventional method, and then the alloys were polished in air at 800.degree. Heat treatment at 30 ° C for 30 minutes, and then mooring and cooling at 40 ° C for 20 minutes to obtain the desired six types of biological contact metals with different component compositions. A member was obtained.
  • the Ti film is formed on the surface by forming a Ti oxide film layer by heat treatment.
  • the oxide film layer of the metal member can effectively prevent ionization and elution of the noble metal such as gold in the metal member, thereby effectively preventing the wearer of the metal member from having gold II allergy. Can be effectively prevented, and precious money)!
  • a metal member made of an alloy containing as a main component can be extremely advantageously applied as an implant material, which has heretofore been impossible to be applied.
  • the excellent compatibility of the membrane layer with living tissue such as bone can be advantageously imparted.
  • the metal member for living body contact according to the present invention, it is possible to effectively prevent contact inflammation or the like from occurring on the mucous membrane or skin of the wearer due to metal allergy due to a noble metal such as gold. And good moldability, better biocompatibility, and even better compatibility with living tissue. An implant material with excellent compatibility can be realized very advantageously.
  • the present invention can effectively prevent the occurrence of metal allergy due to a noble metal in a wearer of a biological contact metal member, and has excellent moldability and biocompatibility.

Abstract

L'invention se rapporte à un matériau métallique en contact avec un corps vivant et qui peut facilement empêcher l'élution d'ions de métaux nobles, prévenir efficacement l'apparition d'allergies provoquées par un métal noble, et être avantageusement utilisé comme matériau d'implantation. La caractéristique de la structure de ce matériau, résolvant le problème rencontré dans un matériau de ce type de la technique antérieure, réside en ce qu'il est formé d'un alliage renfermant un métal noble comme composant principal et du Ti comme composant d'alliage, cet alliage subissant un traitement thermique de façon à former une couche pelliculaire d'oxyde de titane sur sa surface.
PCT/JP1996/003175 1995-11-01 1996-10-30 Materiau metallique en contact avec un corps vivant WO1997016579A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP7/285338 1995-11-01
JP7285338A JPH09125223A (ja) 1995-11-01 1995-11-01 生体接触用金属部材

Publications (1)

Publication Number Publication Date
WO1997016579A1 true WO1997016579A1 (fr) 1997-05-09

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Application Number Title Priority Date Filing Date
PCT/JP1996/003175 WO1997016579A1 (fr) 1995-11-01 1996-10-30 Materiau metallique en contact avec un corps vivant

Country Status (2)

Country Link
JP (1) JPH09125223A (fr)
WO (1) WO1997016579A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10243132A1 (de) * 2002-09-17 2004-04-01 Friedrich-Baur-Beteiligungs-Gmbh Antiinfektiöse, biokompatible Titanoxid-Beschichtungen für Implantate sowie Verfahren zu deren Herstellung

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6811466B1 (ja) * 2019-09-26 2021-01-13 田中貴金属工業株式会社 医療用Ａｕ−Ｐｔ−Ｐｄ合金
JP6789528B1 (ja) * 2019-09-26 2020-11-25 田中貴金属工業株式会社 医療用Ａｕ−Ｐｔ−Ｐｄ合金

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5098451A (fr) * 1973-12-29 1975-08-05
JPS50137836A (fr) * 1974-04-23 1975-11-01
JPS5229424A (en) * 1975-09-01 1977-03-05 Nippon Shiken Kogyo Kk Light weight alloy for enameling ceramics
JPS534720A (en) * 1976-07-03 1978-01-17 Nippon Shiken Kogyo Kk Low carat gold alloy containing aluminium for glazing ceramics
JPS5517092A (en) * 1978-07-18 1980-02-06 Bel Air Ind Inc Electric rag and supplemental portion thereof
JPH06225891A (ja) * 1992-12-07 1994-08-16 Nobelpharma Ab インプラント表面の加工方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5098451A (fr) * 1973-12-29 1975-08-05
JPS50137836A (fr) * 1974-04-23 1975-11-01
JPS5229424A (en) * 1975-09-01 1977-03-05 Nippon Shiken Kogyo Kk Light weight alloy for enameling ceramics
JPS534720A (en) * 1976-07-03 1978-01-17 Nippon Shiken Kogyo Kk Low carat gold alloy containing aluminium for glazing ceramics
JPS5517092A (en) * 1978-07-18 1980-02-06 Bel Air Ind Inc Electric rag and supplemental portion thereof
JPH06225891A (ja) * 1992-12-07 1994-08-16 Nobelpharma Ab インプラント表面の加工方法

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10243132A1 (de) * 2002-09-17 2004-04-01 Friedrich-Baur-Beteiligungs-Gmbh Antiinfektiöse, biokompatible Titanoxid-Beschichtungen für Implantate sowie Verfahren zu deren Herstellung
DE10243132B4 (de) * 2002-09-17 2006-09-14 Biocer Entwicklungs Gmbh Antiinfektiöse, biokompatible Titanoxid-Beschichtungen für Implantate sowie Verfahren zu deren Herstellung

Also Published As

Publication number Publication date
JPH09125223A (ja) 1997-05-13

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