WO1997016579A1

WO1997016579A1 - Living body contacting metal material

Info

Publication number: WO1997016579A1
Application number: PCT/JP1996/003175
Authority: WO
Inventors: Sekio Fukuyo
Original assignee: Sekio Fukuyo
Priority date: 1995-11-01
Filing date: 1996-10-30
Publication date: 1997-05-09
Also published as: JPH09125223A

Abstract

A living body contacting metal material is provided which is capable of easily preventing the elution of noble metal ions, effectively preventing the occurrence of allergy due to a noble metal, and being advantageously used as an implantation material. The gist of the construction of this material which solves the problems encountered in a prior art material of this kind resides in that it is formed out of an alloy containing a nobel metal as a main component and Ti as an alloy component with respect to the noble metal, this alloy being heat treated so as to form a film layer of Ti oxide on the surface thereof.

Description

Description Damage Title of Invention

Metal parts for biological contact Technical field

The present invention relates to a biocontact metal member made of an alloy containing a noble metal as a main component. Background art

Conventionally, alloys containing precious metals as main components, for example, gold alloys such as Au-Ag-Cu alloys and Au-Pd-Ag alloys, have been used as materials for metal parts for medical and decorative purposes. It has been heavily used. For example, attention has been paid to the excellent formability and stability in the oral cavity of such gold alloys and the like, and medical metal members used for dental treatment such as inlays, crowns, bridge dentures, etc. It is widely used as a material to be given, or as a material for manufacturing metal members for decoration such as earrings, rings, necklaces, bracelets, watch bands, etc. by using gold or gold alloy or its excellent decorativeness. It is being done.

By the way, in recent years, the mounting of so-called biological contact metal members, such as medical metal members and decorative metal members made of gold or gold alloy, which are attached to the living body and brought into contact with living tissue. It has been frequently reported that the wearer develops a metal allergy, resulting in rashes, erosions, eruptions, etc., as contact inflammation on the skin of the wearer's restrictive membrane. It is believed that this is due to the ionization and elution of the gold in the biocontact metal member.

Also, as is well known, such a biocontact metal member is Since it is composed of a gold alloy, it is not only excellent in formability but also excellent in stability, and is used by being embedded in biological tissue such as bone. Although it has suitable properties as an imprint material, it is not actually applied at all, and as described above, the gold contained in such a metal member is ionized and eluted. There is a great reason for being swayed.

As described above, in the conventional biocontact metal member, the characteristics of the noble metal such as gold contained in the metal member are utilized and used for various purposes. However, since it is ionized and eluted in the living body, there is a serious problem that a metal allergy is generated in the wearer, and that it cannot be used practically as an imprint material. Disclosure of the invention

Here, the present invention has been made in view of the above-mentioned circumstances, and a solution of the present invention is to provide a medical metal member or decoration made of an alloy containing a precious metal such as gold as a main component. In metal members for biological contact, such as metal members and the like, the elution of metal ions such as gold ions from such metal members can be prevented in a favorable manner. It is an object of the present invention to provide a technique capable of effectively preventing the occurrence of metal allergies in a wearer of the present invention and effectively applying the metal member as an imprint material.

As a result of various studies conducted by the present inventors in order to solve the above-described problems, heat treatment is performed on an alloy containing a noble metal as a main component and containing Ti as an alloy component for the noble metal. Therefore, a Ti oxide film layer is formed on the surface of such an alloy. It has been found that the elution of metal ions can be advantageously suppressed. That is, the present invention has been completed based on such findings, and is characterized by an alloy containing a noble metal as a main component, which is attached to a living body and brought into contact with a living tissue. In the metal member for living body contact, Ti is contained as an alloy component for the noble metal, and an oxide film layer of Ti is formed on the surface of the member by heat treatment.

In short, in the metal member for living body contact according to the present invention, the entire surface is covered with a Ti oxide film layer having a property capable of inhibiting elution of noble metal ions such as gold ions. It is being done.

Therefore, in such a metal member for living body contact, the noble metal such as gold in the metal member can be effectively prevented from being ionized and eluted. It is possible to effectively prevent the occurrence of gold energies, and metal parts made of alloys containing precious metals as main components are extremely advantageous as imprint materials, which were previously inapplicable. It can be applied, and the imprint material is advantageously imparted with excellent compatibility with biological tissue such as bone, which is a conventionally known property of the oxide film layer of Ti. You can be squeezed. Therefore, by using the metal member for living body contact according to the present invention, it is possible to effectively prevent contact inflammation or the like from occurring on the mucous membrane or skin of the wearer due to a metal allergy due to a noble metal such as gold. In addition, an imprint material having good moldability, better biocompatibility, and even better compatibility with living tissue can be realized very advantageously.

Further, in the present invention, a medical metal member made of an alloy containing a noble metal as a main component, which is attached to a living body and brought into contact with a living tissue, is provided. In addition, Ti is contained as an alloy component for the noble gold alloy, and an oxide film layer of Ti is formed on the surface of the member by heat treatment.

Even in such a medical metal member according to the present invention, whether or not the noble metal such as gold in the metal member is ionized and eluted by being formed on the surface of the oxide film layer of Ti. It can be effectively prevented, and as a result, it is possible to effectively prevent the wearer from generating gold allergy, and also has good moldability and better biocompatibility, Furthermore, it can be applied extremely advantageously as an imprint material having excellent compatibility with living tissues.

According to a preferred first aspect of the medical metal member according to the present invention, the medical metal member is configured as an implant for a living body. Thus, a bioimplant material that is more excellent in moldability and biocompatibility and more excellent in compatibility with living tissue can be advantageously realized.

Further, according to a preferred second aspect of the medical metal member according to the present invention, the implant material for a living body is configured as a dental intraosseous implant, whereby the moldability and the biological properties are improved. A dental intraosseous implant that is not only excellent in affinity but also excellent in compatibility with alveolar bone can be advantageously realized, so that dentures and the like attached to the implant can be more stable in the oral cavity It can be fixed.

Further, according to the present invention, a decorative metal member which is attached to a living body and is brought into contact with a biological tissue and which is made of an alloy containing a noble metal as a main component, contains Ti as an alloy component for the noble metal. In addition, a Ti oxide layer is formed on the surface of the member by heat treatment. In such a decorative metal member according to the present invention, the noble metal such as gold in the metal member can be ionized and eluted by the oxide film layer of Ti and being formed on the surface. Therefore, it is possible to effectively prevent the occurrence of metal allergy due to the noble metal in the wearer, and to cause contact inflammation or the like on the mucous membrane or skin of the wearer. _C

According to a preferred first aspect of the decorative metal member according to the present invention, the decorative metal member is constituted by any one of a pierced earring, a ring, a necklace, a bracelet, and a watch band. That is to say, by wearing these ornaments, it is possible to effectively eliminate the possibility of producing metal allergies.

Further, according to an advantageous embodiment of each metal member for living body contact, medical use, and decoration according to the present invention, the alloy providing those metal members may be an Au—Ti alloy, an Au—Ag—C It is composed of u—Ti alloy or Au—Pd—Ag—Ti alloy so that each metal member for biological contact, medical use, and decoration can be used. It can be advantageously applied to conventional metal members made of an alloy such as, for example, metal members frequently used in ornaments and dental treatments. Characteristics can be very effectively demonstrated.

Further, according to one preferred embodiment of the metal member for living body contact according to the present invention, the metal member is contained in a proportion not exceeding 10% by weight of Ti. The precious metal and Ti can be favorably and reliably alloyed without deteriorating the physical properties of the precious metal, which is the main component of the metal member for biological contact, so that the medical metal member 医療 the decorative metal member and the like can be obtained. Therefore, it can be used very advantageously. BEST MODE FOR CARRYING OUT THE INVENTION

By the way, the biocontact metal member according to the present invention contains a noble metal as a main component and a Ti force <as an alloy component for the metal member, as described above. However, the type of such a noble metal is not particularly limited, and may be, for example, Au, Ag, Pd, Pt, etc., which are usually included in metal members for medical use, decoration, etc. One type may be used alone, or two or more types may be used in combination. Au is preferably used as the noble metal.

Further, in such a metal member for biological contact, in addition to the noble metal and Ti, alloy components generally contained in metal members for medical use, decoration, etc., such as Cu and other trace components, are contained. be, whatever permissible not _c short, an alloy providing a biological contacting gold厲部material according to the present invention, as long as it is a noble metal and T i comprising been made to contain a composition of, the invention is not particularly limited For example, Au—Ti-based alloys, Au—Ag—Cu—Ti, Au—Pd—Ag—Ti, Au—Pt—Ag—Cu—Ti, Au—Pd—Ag—Cu— Various alloy compositions such as Ti, Au-Pt-Pd-Ag-Cu-Ti can be employed.

Further, the composition ratio of each of the alloy components is not limited at all, and a general composition ratio can be appropriately adopted.In particular, Ti is not limited to any alloy composition. It is preferable that the content is not more than 10% by weight. However, if the Ti content exceeds 10% by weight, the Ti will be excessively contained in the precious metal, which is the main component, and as a result, the precious metal will be alloyed with the Ti. Not only becomes difficult, but also due to the presence of large amounts of Ti in the alloy Therefore, the physical properties of the noble metal are impaired. In this sense, the content ratio of Ti is desirably preferably 5% by weight or less, particularly preferably 2% by weight or less. As described above, when the content ratio of Ti is set to 2% by weight or less, the color of the surface of the biocontact metal member can be effectively maintained at the color of the noble metal, and the metal member member ^ It can be used more effectively for decoration.

In the metal member for biological contact according to the present invention, an oxide film layer of Ti is formed on the surface of the metal member by an appropriate heat treatment. The heat treatment method for forming such an Ti oxide film layer is not particularly limited. That is, when heat treatment is performed on such a metal member, a one-piece heat treatment apparatus can be used, and the heat treatment temperature is determined by the melting point (melting point) of each alloy component. The heat treatment time is appropriately determined in consideration of such factors, and the appropriate heat treatment time is determined in accordance with the determined heat treatment temperature and the like. When the heat treatment is performed at a relatively high temperature for a short time, the color of the surface of the obtained metal member can be advantageously maintained at the color of the noble metal.

The thickness of the oxide layer of Ti formed on the surface of the biocontact metal member by the heat treatment is not limited at all, but is set to about 10 m at a time. .

By the way, the Ti oxide film layer formed in this manner has features that cannot be seen in other metal oxide films, such as being able to prevent elution of precious metal ions, as described above. Accordingly, in the metal member for biological contact having such an oxide film layer of T i formed on the surface, the ionization and elution of the noble metal in the metal member can be effectively prevented. It is. As a result, in such a metal member for living body contact, a metal allergy may occur in a wearer of the metal member. An imprint material that can be effectively prevented, has excellent moldability and biocompatibility, which are inherent properties of the metal, and also has convenient compatibility with biomaterials having an oxide layer of Ti. Can be used very advantageously.

Then, a metal member for living body contact having such extremely excellent characteristics is attached to a living body, and is made of a metal member to be brought into contact with living tissue, for example, embedded in alveolar bone, and a denture or the like is placed in the alveolar bone. Conventionally, alloys that use precious metals as the main component, such as oral implants (dental endosseous implants) that are fixed to bones and bolts that are embedded in fractured bones to connect such bones, are not applicable. As a medical metal member such as a metal member for general dental treatment, such as a bioimplant material, an inlay, a crown, and a bridge denture, which has been made possible, and a pierced earring, a ring, a necklace, and a bracelet. It can be used very advantageously as a decorative metal member such as a watch band or a watch band.

By the way, such a biocontact metal member according to the present invention is advantageously manufactured as follows.

That is, first, T i and, if necessary, other alloy components are dissolved in a noble metal by a conventional method, for example, an arc melting method, to obtain a melt (molten metal). In order to avoid oxidation of Ti during the dissolving operation, the dissolving operation needs to be performed in an inert gas atmosphere such as Ar gas.

Next, the melt obtained in this manner is manufactured to obtain an ingot, and thereafter, the ingot is subjected to general plastic working, forming, or the like, for example, press forming to obtain a predetermined shape. Is obtained.

Then, using the obtained alloy member, the surface thereof is polished by a known method, and then subjected to a general heat treatment in the air, so that the surface of the alloy member is Form an oxide layer of Ti for the purpose Is obtained.

The biocontact metal member configured according to the present invention may be an alloy member having a predetermined shape by using a general alloy molding and manufacturing method such as powder metallurgy, in addition to the above-described manufacturing method. It can also be manufactured by manufacturing the alloy member and then heat-treating the alloy member. Even when such a method is adopted, the method of heat treatment of the alloy member is not particularly limited, as in the above-described production method. Example

Hereinafter, typical examples of the present invention will be described to clarify the present invention more specifically. However, the present invention is not limited by the description of such examples. It is needless to say that it is not a thing. In addition, in addition to the following examples, the present invention may be variously modified based on the knowledge of those skilled in the art without departing from the spirit of the present invention. It should be understood that modifications, improvements, etc. can be made.

As described above, Au is used as a noble metal, and this Au is included as a main component, and at the same time, Ti or Ti and Ag are included as alloy components with respect to the Au, and these metals are used. Each of Au, Ti, and Ag was separately charged into a predetermined crucible so as to obtain six kinds of alloys having the composition ratios shown in Table 1 below. r Dissolution was performed by performing arc melting according to a conventional method in an atmosphere to obtain six types of melts (melts) having different component compositions from each other. Next, the six types of melts were cooled to obtain six ingots, and each of the ingots was subjected to a single press process to obtain a 1 mm x 5 mm x A small piece alloy having a size of 5 mm was formed. And the composition of each component Different Six alloy, _c Table 1 were respectively alloys 1-6

Then, using the six kinds of alloys (alloys 1 to 6) thus obtained and pure gold for comparison, observing the color of each alloy and the surface of the pure gold, and following the usual method, The Vickers hardness of these metals was examined, and each metal was bent at 90 °, and the occurrence of fracture at that time was examined. The results are shown in Table 2 below. In Table 2, values obtained by measuring the Vickers hardness of each metal three times are shown as the Vickers hardness. Table 2

As is evident from the results in Table 2, an alloy containing Au as a main component and containing Ti as an alloy component with respect to the Au has a low Ti content. Specifically, when the content of Ti is about 2% by weight or less, there is no remarkable decrease in physical properties even when compared with pure gold, and thus the physical properties of Au are effective. It is confirmed that the power has been secured. Next, using the six kinds of alloys (alloys 1 to 6) obtained as described above, the surface of each alloy was polished according to a conventional method, and then the alloys were polished in air at 800.degree. Heat treatment at 30 ° C for 30 minutes, and then mooring and cooling at 40 ° C for 20 minutes to obtain the desired six types of biological contact metals with different component compositions. A member was obtained. Then, using these six types of metal members for biological contact and a metal member for biological contact made of pure gold for comparison, their surface structures were observed with an XDi microanalyzer. . As a result, in the case of a metal member for living body contact having a component composition according to the present invention and made of a heat-treated alloy, the entire surface of the member has a thickness of about 10 im. It was observed that the oxide film layer of i was formed. On the other hand, in the case of the metal member for living body made of pure gold, no such oxide film layer of Ti was found on the surface.

As is clear from the above description, in the biocontact metal material according to the present invention, the Ti film is formed on the surface by forming a Ti oxide film layer by heat treatment. The oxide film layer of the metal member can effectively prevent ionization and elution of the noble metal such as gold in the metal member, thereby effectively preventing the wearer of the metal member from having gold II allergy. Can be effectively prevented, and precious money)! A metal member made of an alloy containing as a main component can be extremely advantageously applied as an implant material, which has heretofore been impossible to be applied. The excellent compatibility of the membrane layer with living tissue such as bone can be advantageously imparted.

Therefore, by using the metal member for living body contact according to the present invention, it is possible to effectively prevent contact inflammation or the like from occurring on the mucous membrane or skin of the wearer due to metal allergy due to a noble metal such as gold. And good moldability, better biocompatibility, and even better compatibility with living tissue. An implant material with excellent compatibility can be realized very advantageously.

And, by using such a metal member for living body contact according to the present invention, in particular, a metal member for medical use, a metal member for decoration, and the like, the above-mentioned excellent features of the metal members are as follows. It can be very effective. Industrial applicability

As is apparent from the above description, the present invention can effectively prevent the occurrence of metal allergy due to a noble metal in a wearer of a biological contact metal member, and has excellent moldability and biocompatibility. In particular, it is possible to advantageously provide a metal member for biological contact that can be advantageously applied as an implant material.

Claims

The scope of the claims

1. A metal member for living body contact which is attached to a living body and brought into contact with a living tissue and is made of an alloy containing a noble metal as a main component. The metal member contains Ti as an alloy component for the noble metal and the member. A metal member for living body contact, characterized in that a Ti oxide film layer is formed on a surface of the substrate by heat treatment.

2. A medical metal member made of an alloy containing a noble metal as a main component, which is attached to a living body and brought into contact with a living tissue, containing Ti as an alloy component for the noble metal, and A metal member for medical use, characterized in that a Ti oxide film layer is formed by heat treatment on the surface of the metal member.

3. The medical metal member according to claim 2, wherein the medical metal member is a bioimplant material.

4. The medical metal member according to claim 3, wherein the implant material for a living body is a dental intraosseous implant.

5. A decorative metal member made of an alloy containing a noble metal as a main component that is attached to a living body and brought into contact with a living tissue, containing Ti as an alloying component for the noble metal II, and A decorative metal member, wherein a Ti oxide film layer is formed on a surface of the member by heat treatment.

6. The decorative metal member according to claim 5, wherein the decorative metal member is any one of a pierced earring, a ring, a necklace, a breathlet, and a watch band.

7. The biocontact metal according to claim 1, wherein the alloy that provides the metal member is Hachiryu 1 alloy, Au-Ag-Cu-Ti alloy, or Au-Pd-Ag-Ti alloy. Element.

8. The alloy according to claim 2, wherein the alloy that provides the metal member is an eighteen-one alloy, an Au-Ag-Cu-Ti alloy, or an Au-Pd-Ag-Ti alloy. The medical metal member according to any one of the above.

9. The method according to claim 5, wherein the alloy that provides the metal member is an Au-Ti alloy, an Au-Ag-Cu-Ti alloy, or an Au-Pd-Ag-Ti alloy. The decorative metal member as described in the above.

10. The biocontact metal according to claim 1 or 7, wherein the Ti force is contained in a ratio not exceeding 10% by weight. Element.