JPH09125223A - Metallic member for contact with living body - Google Patents

Abstract

PROBLEM TO BE SOLVED: To effectively inhibit the occurrence of metal allergy caused by noble metal by incorporating Ti as an alloy component into the composition of a metallic member for contact with a living body, composed of an alloy containing noble metal as essential component, and also forming a Ti oxide film layer on the surface of the member. SOLUTION: In a metallic member (such as artificial tooth, piercing-type earring, and ring) for contact with a living body, to be attached to a living body and brought into contact with viable tissue and consisting of an alloy composed essentially of noble metal (Au, Ag, Pd, Pt, etc.), Ti is incorporated as an alloy component into the noble metal and also a Ti oxide film layer is formed on the surface of the member by heat treatment. At this time, Ti content is regulated to <= about 5wt.%, preferably <= about 2wt.%, and also the film thickness of the Ti oxide film layer is regulated to about 10μm. By this method, the contact inflammation, etc., of mucous membrane and skin, caused by metal allergy, can be effectively prevented, and also formability can be improved.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a biological contact metal member made of an alloy containing a noble metal as a main component, and more particularly,
A metal member for living body contact, which can effectively prevent the occurrence of metal allergy due to a noble metal in a wearer of such a metal member, and which is excellent in moldability and biocompatibility and can be advantageously applied particularly as an implant material. It is about.

[0002]

2. Description of the Related Art Conventionally, an alloy containing a noble metal as a main component, for example, an Au-Ag-Cu alloy, Au-Pd-Ag.
Gold alloys such as alloys have been widely used as materials for metal members for medical purposes, decorations, and the like. For example, those gold alloys, etc. are noted for their excellent moldability and stability in the oral cavity, etc., and are mainly used for inlays, crowns, bridge dentures, and other medical metal members used for dental treatment. Gold or gold alloy is used as a material to give pierced earrings, rings, necklaces, bracelets, due to its excellent decorative properties.
They are widely used as materials for manufacturing decorative metal members such as watch bands.

By the way, in recent years, a wearer of a so-called biological contact metal member such as a medical metal member or a decorative metal member made of gold or a gold alloy, which is attached to a living body and brought into contact with a living tissue, has been recently used. However, it has been frequently reported that a metal allergy is caused, which causes a rash, an erosion, an ulcer or the like as a contact inflammation on the mucous membrane and skin of the wearer. It is considered that this is because gold in the metal member for contact with living body is ionized and eluted.

Further, as is well known, such a metal member for living body contact is not only excellent in molding workability but also stable in stability because it is made of a gold alloy. Although it has excellent characteristics as an implant material to be used by being embedded in a living tissue such as bone, it is not actually applied at all, and this is also as described above. , In such a metal member,
The reason is that the gold contained in it is ionized and eluted.

As described above, in the conventional metal member for contact with a living body, the characteristics of the noble metal such as gold contained therein are utilized and used for various purposes, but on the other hand, Since such a noble metal is ionized and eluted in a living body, a metal allergy is caused in the wearer, and there is an inherent problem that it cannot be put to practical use as an implant material.

[0006]

The present invention has been made in view of the circumstances as described above, and the problem to be solved is that an alloy containing a precious metal such as gold as a main component. In a metal member for living body contact including a medical metal member and a decorative metal member, the elution of noble metal ions such as gold ions from these metal members can be favorably prevented. Thus, it is an object of the present invention to provide a technique capable of effectively preventing the occurrence of metal allergy in a wearer of such a metal member and applying the metal member advantageously as an implant material.

[0007]

Then, the present inventors have
In order to solve the problems as described above, as a result of various studies, by heat treating an alloy containing a precious metal as a main component and Ti as an alloy component for the precious metal,
It has been found that a Ti oxide film layer is formed on the surface of such an alloy, and that such a Ti oxide film layer can advantageously prevent the elution of precious metal ions.

That is, the present invention has been completed on the basis of such knowledge, and is characterized in that the main component is a noble metal that is attached to a living body and brought into contact with living tissue. In a metal member for biological contact made of an alloy, Ti is used as an alloy component for the noble metal.
And containing T by heat treatment on the surface of the member.
This is because the oxide film layer of i was formed.

In short, the metal member for biological contact according to the present invention is formed by covering the entire surface of the member with a Ti oxide film layer having a characteristic capable of preventing the elution of precious metal ions such as gold ions. -ing

Therefore, in such a metal member for living body contact, it is possible to effectively prevent the noble metal such as gold in the metal member from being ionized and eluted, whereby the wearer of the metal member can be prevented. It is possible to effectively prevent the occurrence of metal allergies, and it is possible to apply the metal member made of an alloy containing a noble metal as a main component extremely advantageously as an implant material that has hitherto been impossible to apply. Moreover, for such implant materials,
This is because the Ti oxide film layer can be advantageously imparted with a conventionally known characteristic of being excellently compatible with living tissues such as bone.

Therefore, by using the metal member for contacting a living body according to the present invention, it is effective to cause contact inflammation or the like on the mucous membrane and skin of the wearer due to metal allergy caused by a noble metal such as gold. Can be prevented by
In addition, an implant material having good moldability, better biocompatibility, and further excellent compatibility with living tissues can be extremely advantageously realized.

Further, according to the present invention, a medical metal member made of an alloy containing a noble metal as a main component, which is attached to a living body and brought into contact with a living tissue, contains Ti as an alloy component for the noble metal. Another feature is that a Ti oxide film layer is formed on the surface of the member by heat treatment.

Even in such a medical metal member according to the present invention, since the Ti oxide film layer is formed on the surface, the noble metal such as gold in the metal member is ionized and eluted. Can be effectively prevented, and as a result, it is possible to effectively prevent the occurrence of metal allergy to the wearer, good moldability and better biocompatibility, and further It can be applied extremely advantageously as an implant material having excellent compatibility with living tissues.

According to the first preferred aspect of the medical metal member according to the present invention, the medical metal member comprises:
Since it is configured as a biomedical implant material, a biomedical implant material that is more excellent in moldability and biocompatibility than conventional products and has excellent compatibility with living tissue can be advantageously realized. .

Further, according to a desirable second aspect of the medical metal member according to the present invention, the biomedical implant material is configured as a dental endosseous implant, whereby moldability and biomedical properties are improved. A dental endosseous implant which is not only excellent in affinity but also excellent in compatibility with alveolar bone can be advantageously realized, and thus, a denture or the like attached to the implant, in the oral cavity,
It can be fixed more stably.

Further, according to the present invention, a decorative metal member made of an alloy containing a noble metal as a main component, which is attached to a living body and brought into contact with living tissue,
It is also characterized by containing Ti as an alloy component for the noble metal and forming a Ti oxide film layer on the surface of the member by heat treatment.

In such a decorative metal member according to the present invention, since the oxide film layer of Ti is formed on the surface, the noble metal such as gold in the metal member is ionized and eluted. Can be effectively prevented, and thus it is possible to very effectively prevent a metal allergy due to the precious metal from occurring in the wearer and causing contact inflammation or the like on the mucous membrane or skin of the wearer. .

According to the desirable first aspect of the decorative metal member according to the present invention, the decorative metal member is made of any one of piercings, rings, necklaces, bracelets, and watch bands. By doing so, it is possible to effectively eliminate the metal allergy caused by wearing these ornaments.

Further, according to the present invention, for biological contact, medical use,
According to an advantageous aspect of each of the decorative metal members, the alloy providing the metal members is Au-Ti alloy, Au-
Ag-Cu-Ti alloy, or Au-Pd-Ag-Ti
It is composed of alloys, so that each metal member for living body contact, medical treatment, and decoration can be used for conventional metal members composed of those alloys, for example, ornaments and dental treatments. It can be advantageously applied to a frequently used metal member and the like, and in such a metal member, the excellent characteristics as described above can be extremely effectively exhibited.

Furthermore, according to one of the preferred embodiments of the bio-contact metal member according to the present invention, the Ti is contained in a proportion not exceeding 10% by weight, whereby the bio-contact is achieved. The precious metal, which is the main component of the metal member for use in the metal, can be satisfactorily and reliably alloyed with the precious metal without impairing the physical properties of the precious metal member, and thus is extremely advantageously used as a medical metal member, a decorative metal member, etc. It can be done.

[0021]

BEST MODE FOR CARRYING OUT THE INVENTION By the way, as described above, in the metal member for contacting a living body according to the present invention, as a main component,
The noble metal, and Ti as an alloy component for the noble metal
However, the kind of noble metal is not particularly limited,
For example, from among those usually contained in metal members for medical treatment and decoration such as Au, Ag, Pd and Pt, one kind may be used alone or two or more kinds may be used in combination. Become. Au is used as a preferable noble metal.

In addition to such precious metal and Ti, the metal member for contact with a living body is made to contain alloy components generally contained in metal members for medical use, decoration, etc., such as Cu and other trace components. However, it doesn't matter.

In short, the alloy for providing the metallic member for biological contact according to the present invention is not particularly limited in composition as long as it is made of a noble metal and Ti contained therein. For example, Au-Ti. System alloys, Au-Ag
-Cu-Ti, Au-Pd-Ag-Ti, Au-Pt-
Ag-Cu-Ti, Au-Pd-Ag-Cu-Ti, A
Various alloy compositions such as u-Pt-Pd-Ag-Cu-Ti can be adopted.

Further, the composition ratio of each alloy component is not limited in any way, and a general composition ratio can be appropriately adopted. In particular, Ti is used in any alloy composition. Also, it is preferable that the content is 10% by weight or less. It ’s
When Ti is contained in an amount of more than 10% by weight, Ti is excessively contained with respect to the noble metal as a main component, which makes it difficult to alloy the noble metal and Ti, and Large amount of Ti in
This is because the presence of the metal impairs the physical properties of the precious metal. In that sense, the Ti content is preferably 5% by weight or less, and particularly preferably 2% by weight or less. As described above, when the content ratio of Ti is 2% by weight or less, the color of the surface of the metal member for living body contact can be effectively kept to the color of noble metal, and the metal member is For use
It can be used more effectively.

The biological contact metal member according to the present invention is formed by forming a Ti oxide film layer on the surface of the metal member by an appropriate heat treatment. The heat treatment method for forming such a Ti oxide film layer is also not particularly limited. That is, when heat treating such a metal member, a general heat treatment apparatus can be used, and the heat treatment temperature takes into consideration the melting point (melting point) of each alloy component. The heat treatment time is appropriately determined according to the determined heat treatment temperature and the like. When the heat treatment is performed at a relatively high temperature for a short time, the color of the surface of the obtained metal member can be advantageously maintained to the color of the noble metal.

The film thickness of the Ti oxide film layer formed on the surface of the metal member for living body contact by the heat treatment is also
Although not limited in any way, generally 10 μ
m.

By the way, the Ti thus formed is
As described above, the oxide film layer of Ti has the characteristic that it cannot block the elution of the noble metal ions, which is not found in the oxide films of other metals. In a metal member for living body contact having a layer formed on the surface, it is possible to effectively prevent the noble metal in the metal member from being ionized and eluted. And as a result, in such a biological contact metal member,
It is possible to effectively prevent metal allergies from occurring in the wearer of the metal member, and also to have excellent moldability and biocompatibility, which are the characteristics peculiar to a precious metal, and further, a living body having a Ti oxide film layer. It can be extremely advantageously used as an implant material having excellent compatibility with tissues.

[0028] Then, the metal member for contacting a living body having such extremely excellent characteristics is attached to a living body to be brought into contact with a living body tissue, for example, embedded in an alveolar bone to implant a denture. Conventionally, alloys mainly composed of precious metals such as oral implants (dental endosseous implants) that are fixed to the alveolar bone, bolts that are embedded in fractured bones and connect such bones are not applicable. Biomaterial implants, inlays, etc.
As a metal member for medical treatment such as a metal member for general dental treatment such as a crown and a bridge, a piercing, a ring, a necklace,
It can be extremely advantageously used as a decorative metal member such as a bracelet and a watch band.

By the way, the biological contact metal member according to the present invention is advantageously manufactured as follows.

That is, first, for precious metals, Ti
And, if necessary, other alloy components are melted by a conventional method, for example, by a method such as arc melting, to obtain a melt (molten metal). In order to avoid oxidation of Ti during this melting operation, such melting operation needs to be performed in an atmosphere of an inert gas such as Ar gas.

Next, the melt thus obtained is cast to obtain an ingot, and then the ingot is subjected to general plastic working, forming, etc., for example, press forming, to obtain an alloy having a predetermined shape. Get the members.

Then, after using the obtained alloy member, the surface of the alloy member is polished by a known method, and then a general heat treatment is performed in the atmosphere to obtain the alloy member. An oxide film layer of Ti is formed on the surface to obtain the target metal member for contact with a living body.

The biological contact metal member configured according to the present invention can be manufactured by powder metallurgy or the like in addition to the above-described manufacturing method.
It can also be manufactured by manufacturing an alloy member having a predetermined shape using a general alloy molding and manufacturing method, and then subjecting the alloy member to heat treatment. Even when such a method is adopted, the method of heat treatment of the alloy member is not particularly limited, as in the above-described manufacturing method.

[0034]

Hereinafter, typical examples of the present invention will be described to clarify the present invention more specifically. However, the present invention imposes no restrictions on the description of such examples. It goes without saying that you don't receive anything. In addition, in addition to the following examples, the present invention may further include various changes and modifications based on the knowledge of those skilled in the art without departing from the spirit of the present invention. , Improvements and the like can be added.

First, Au is used as the noble metal.
Six kinds of alloys containing not only u as a main component but also Ti or Ti and Ag as an alloy component for Au, and containing these metals in the composition ratios shown in Table 1 below. Au,
After each metal of Ti and Ag is separately charged into a predetermined crucible, they are melted by performing arc melting according to a conventional method in an Ar atmosphere to dissolve them, and 6 kinds of melts (molten metal) having mutually different composition Got Next, after cooling these 6 kinds of melts to obtain 6 ingots, general press working is performed on each of the ingots, and a small piece having a size of 1 mm × 5 mm × 5 mm is obtained. A flaky alloy was formed. Then, six kinds of alloys having different component compositions from each other were designated as alloys 1 to 6, respectively.

[0036]

[Table 1]

Then, using the six kinds of alloys thus obtained (alloys 1 to 6) and pure gold for comparison, the color of the surface of each alloy and pure gold was observed, and those metals were also subjected to the conventional method. The Vickers hardness of the
It was bent into a sheet and examined for the occurrence of breakage. The results are shown in Table 2 below. In addition, in Table 2, as the Vickers hardness, values obtained by measuring the Vickers hardness of each metal three times are shown.

[0038]

[Table 2]

As is clear from the results shown in Table 2,
An alloy containing Au as a main component and Ti as an alloy component for the Au, having a low Ti content, specifically, a Ti content of about 2% by weight or less. In comparison with pure gold, there is no significant deterioration in the physical properties, and
It is confirmed that the physical properties of u can be effectively secured.

Next, after using the six kinds of alloys (alloys 1 to 6) obtained as described above and polishing the surface of each alloy by a conventional method, the alloys were exposed to the air in the atmosphere. 800
Heat treatment was performed at 30 ° C. for 30 minutes, and then mooring was performed for 20 minutes at a temperature of 400 ° C., followed by cooling for cooling for 20 minutes to obtain 6 types of desired metal members for contact with living body having different component compositions. And, using these 6 types of metal members for bio-contact and bio-metal members made of pure gold for comparison,
The surface structure of them was analyzed by an X-ray microanalyzer.
Observed.

As a result, it has a component composition according to the invention,
In addition, it was observed that in the metal member for biological contact made of the heat-treated alloy, a Ti oxide film layer having a thickness of about 10 μm was formed on the entire surface of the metal member. On the other hand, in the case of a biological contact metal member made of pure gold,
No such oxide layer of Ti was observed on the surface.

[0042]

As is clear from the above description, the biological contact metal member according to the present invention is formed by forming a Ti oxide film layer on the surface by heat treatment. The Ti oxide film layer can effectively prevent ionization and elution of a noble metal such as gold in the metal member, which effectively causes a metal allergy to the wearer of the metal member. In addition to being capable of being prevented by the above, a metal member made of an alloy containing a precious metal as a main component can be extremely advantageously applied as an implant material that has hitherto been impossible to apply. The excellent compatibility of the Ti oxide film layer with living tissue such as bone can be advantageously imparted.

Therefore, by using the metal member for biological contact according to the present invention, it is effective that contact mucosa or skin of the wearer is caused due to metal allergy caused by a noble metal such as gold. Can be prevented by
In addition, an implant material having good moldability, better biocompatibility, and further excellent compatibility with living tissues can be extremely advantageously realized.

By using such a metal member for contact with a living body according to the present invention as a metal member for medical use or a metal member for decoration, etc., the metal member has excellent characteristics as described above. , Can be demonstrated very effectively.

Continuation of the front page (51) Int.Cl. ⁶ Identification code Office reference number FI Technical display location A61F 2/28 A61F 2/28 A61L 27/00 A61L 27/00 L C22C 5/02 C22C 5/02

Claims (10)

[Claims] 1. A metal member for living body contact, which is attached to a living body and brought into contact with living tissue, and which comprises an alloy containing a noble metal as a main component, and which contains Ti as an alloying component for the noble metal, A biological contact metal member, characterized in that a Ti oxide film layer is formed on the surface by heat treatment. 2. A medical metal member, which is attached to a living body and brought into contact with a living tissue, comprising an alloy containing a noble metal as a main component, which contains Ti as an alloy component for the noble metal and has a surface of the member. A medical metal member characterized in that an oxide film layer of Ti is formed by heat treatment. 3. The medical metal member according to claim 2, wherein the medical metal member is a biomedical implant material. 4. The medical metal member according to claim 3, wherein the biomedical implant material is a dental endosseous implant. 5. A decorative metal member, which is attached to a living body and is brought into contact with a living tissue, made of an alloy containing a noble metal as a main component, and contains Ti as an alloy component for the noble metal, and the surface of the member. A decorative metal member, characterized in that a Ti oxide film layer is formed by heat treatment. 6. The decorative metal member is a piercing, a ring,
The decorative metal member according to claim 5, which is one of a necklace, a bracelet, and a watch band. 7. The alloy providing the metal member is Au-T.
i alloy, Au-Ag-Cu-Ti alloy, or Au-P
The metal member for biological contact according to claim 1, which is a d-Ag-Ti alloy. 8. The alloy providing the metal member is Au-T.
i alloy, Au-Ag-Cu-Ti alloy, or Au-P
The medical metal member according to any one of claims 2 to 4, which is a d-Ag-Ti alloy. 9. The alloy providing the metal member is Au-T.
i alloy, Au-Ag-Cu-Ti alloy, or Au-P
The decorative metal member according to claim 5 or 6, which is a d-Ag-Ti alloy. 10. The biological contact metal member according to claim 1, wherein the Ti is contained in a proportion not exceeding 10% by weight.